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Search of human proteins with 50845418
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50845418 WNK lysine deficient protein kinase 3 isoform 1
[Homo sapiens]
(1800 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50845418 WNK lysine deficient protein kinase 3 isoform 1 [Hom... 3570 0.0
gi|50845416 WNK lysine deficient protein kinase 3 isoform 2 [Hom... 3420 0.0
gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens] 663 0.0
gi|148612809 WNK lysine deficient protein kinase 1 [Homo sapiens] 649 0.0
gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens] 560 e-159
gi|7019333 nuclear receptor binding protein [Homo sapiens] 153 2e-36
gi|148839316 NIMA-related kinase 4 [Homo sapiens] 122 3e-27
gi|42794767 mitogen-activated protein kinase kinase kinase 3 iso... 120 1e-26
gi|42794765 mitogen-activated protein kinase kinase kinase 3 iso... 120 1e-26
gi|32483399 p21-activated kinase 2 [Homo sapiens] 120 2e-26
gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Ho... 115 3e-25
gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens] 114 9e-25
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens] 113 1e-24
gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens] 113 1e-24
gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens] 113 1e-24
gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens] 113 1e-24
gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens] 113 1e-24
gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens] 113 1e-24
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 111 6e-24
gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo sa... 111 7e-24
gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo sa... 111 7e-24
gi|19424132 NIMA-related kinase 7 [Homo sapiens] 110 1e-23
gi|4507831 Unc-51-like kinase 1 [Homo sapiens] 109 2e-23
gi|150456432 unc-51-like kinase 3 [Homo sapiens] 109 2e-23
gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens] 109 3e-23
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 107 8e-23
gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens] 107 1e-22
gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens] 107 1e-22
gi|55956904 mitogen-activated protein kinase kinase kinase 4 iso... 107 1e-22
gi|153945765 mitogen-activated protein kinase kinase kinase 1 [H... 106 2e-22
>gi|50845418 WNK lysine deficient protein kinase 3 isoform 1 [Homo
sapiens]
Length = 1800
Score = 3570 bits (9257), Expect = 0.0
Identities = 1800/1800 (100%), Positives = 1800/1800 (100%)
Query: 1 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR 60
MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR
Sbjct: 1 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR 60
Query: 61 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC 120
KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC
Sbjct: 61 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC 120
Query: 121 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD 180
FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD
Sbjct: 121 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD 180
Query: 181 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK 240
RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK
Sbjct: 181 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK 240
Query: 241 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL 300
RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL
Sbjct: 241 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL 300
Query: 301 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK 360
MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK
Sbjct: 301 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK 360
Query: 361 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD 420
VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD
Sbjct: 361 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD 420
Query: 421 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV 480
CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV
Sbjct: 421 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV 480
Query: 481 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE 540
AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE
Sbjct: 481 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE 540
Query: 541 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV 600
TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV
Sbjct: 541 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV 600
Query: 601 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT 660
SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT
Sbjct: 601 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT 660
Query: 661 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS 720
VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS
Sbjct: 661 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS 720
Query: 721 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD 780
GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD
Sbjct: 721 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD 780
Query: 781 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS 840
APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS
Sbjct: 781 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS 840
Query: 841 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR 900
QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR
Sbjct: 841 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR 900
Query: 901 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL 960
HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL
Sbjct: 901 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL 960
Query: 961 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH 1020
YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH
Sbjct: 961 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH 1020
Query: 1021 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP 1080
PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP
Sbjct: 1021 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP 1080
Query: 1081 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS 1140
GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS
Sbjct: 1081 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS 1140
Query: 1141 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF 1200
IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF
Sbjct: 1141 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF 1200
Query: 1201 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGGGYFGLSFTCPSL 1260
KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGGGYFGLSFTCPSL
Sbjct: 1201 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGGGYFGLSFTCPSL 1260
Query: 1261 KNPISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRSAIAPDPIPLTRESTADTR 1320
KNPISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRSAIAPDPIPLTRESTADTR
Sbjct: 1261 KNPISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRSAIAPDPIPLTRESTADTR 1320
Query: 1321 ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL 1380
ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL
Sbjct: 1321 ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL 1380
Query: 1381 VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE 1440
VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE
Sbjct: 1381 VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE 1440
Query: 1441 ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH 1500
ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH
Sbjct: 1441 ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH 1500
Query: 1501 EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ 1560
EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ
Sbjct: 1501 EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ 1560
Query: 1561 ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVATGKSCLIN 1620
ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVATGKSCLIN
Sbjct: 1561 ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVATGKSCLIN 1620
Query: 1621 ELENPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHK 1680
ELENPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHK
Sbjct: 1621 ELENPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHK 1680
Query: 1681 LETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVC 1740
LETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVC
Sbjct: 1681 LETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVC 1740
Query: 1741 QYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK 1800
QYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK
Sbjct: 1741 QYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK 1800
>gi|50845416 WNK lysine deficient protein kinase 3 isoform 2 [Homo
sapiens]
Length = 1743
Score = 3420 bits (8869), Expect = 0.0
Identities = 1742/1800 (96%), Positives = 1743/1800 (96%), Gaps = 57/1800 (3%)
Query: 1 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR 60
MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR
Sbjct: 1 MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFR 60
Query: 61 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC 120
KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC
Sbjct: 61 KSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC 120
Query: 121 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD 180
FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD
Sbjct: 121 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQD 180
Query: 181 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK 240
RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK
Sbjct: 181 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK 240
Query: 241 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL 300
RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL
Sbjct: 241 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL 300
Query: 301 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK 360
MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK
Sbjct: 301 MRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK 360
Query: 361 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD 420
VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD
Sbjct: 361 VTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD 420
Query: 421 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV 480
CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV
Sbjct: 421 CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAV 480
Query: 481 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE 540
AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE
Sbjct: 481 AKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEE 540
Query: 541 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV 600
TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV
Sbjct: 541 TEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMV 600
Query: 601 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT 660
SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT
Sbjct: 601 SNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPT 660
Query: 661 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS 720
VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS
Sbjct: 661 VVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPS 720
Query: 721 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD 780
GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD
Sbjct: 721 GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGD 780
Query: 781 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS 840
APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS
Sbjct: 781 APEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSS 840
Query: 841 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR 900
QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR
Sbjct: 841 QTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGR 900
Query: 901 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL 960
HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL
Sbjct: 901 HPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAIL 960
Query: 961 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH 1020
YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH
Sbjct: 961 YQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSH 1020
Query: 1021 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP 1080
PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP
Sbjct: 1021 PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTP 1080
Query: 1081 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS 1140
GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS
Sbjct: 1081 GLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQS 1140
Query: 1141 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF 1200
IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF
Sbjct: 1141 IDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVF 1200
Query: 1201 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGGGYFGLSFTCPSL 1260
KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTG
Sbjct: 1201 KRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTG------------- 1247
Query: 1261 KNPISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRSAIAPDPIPLTRESTADTR 1320
VETEEMRSAIAPDPIPLTRESTADTR
Sbjct: 1248 ----------------------------------VETEEMRSAIAPDPIPLTRESTADTR 1273
Query: 1321 ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL 1380
ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL
Sbjct: 1274 ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQL 1333
Query: 1381 VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE 1440
VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE
Sbjct: 1334 VEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFE 1393
Query: 1441 ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH 1500
ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH
Sbjct: 1394 ETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHH 1453
Query: 1501 EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ 1560
EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ
Sbjct: 1454 EEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQ 1513
Query: 1561 ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVATGKSCLIN 1620
ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVAT
Sbjct: 1514 ELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVAT------- 1566
Query: 1621 ELENPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHK 1680
+PLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHK
Sbjct: 1567 ---DPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHK 1623
Query: 1681 LETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVC 1740
LETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVC
Sbjct: 1624 LETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVC 1683
Query: 1741 QYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK 1800
QYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK
Sbjct: 1684 QYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK 1743
>gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]
Length = 2217
Score = 663 bits (1711), Expect = 0.0
Identities = 377/600 (62%), Positives = 427/600 (71%), Gaps = 40/600 (6%)
Query: 122 KEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDR 181
+++ E+E ++E ++KAVATS GRFLKFDIELGRG+FKTVYKGLDTETWVEVAWCELQDR
Sbjct: 170 RDEPEEEEDDEDDLKAVATSLDGRFLKFDIELGRGSFKTVYKGLDTETWVEVAWCELQDR 229
Query: 182 KLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKR 241
KLTK E+QRFKEEAEMLKGLQHPNIVRFYD WES KGK+CIVLVTELMTSGTLKTYLKR
Sbjct: 230 KLTKLERQRFKEEAEMLKGLQHPNIVRFYDFWESSAKGKRCIVLVTELMTSGTLKTYLKR 289
Query: 242 FKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLM 301
FKVMKPKVLRSWCRQILKGL FLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL
Sbjct: 290 FKVMKPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLK 349
Query: 302 RTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKV 361
R SFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKV
Sbjct: 350 RASFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKV 409
Query: 362 TSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDDC 421
T GIKPASF KV DPE+KEII CI +NK ER I+DLL+HAFFAEDTG+RVELAEED
Sbjct: 410 TCGIKPASFEKVHDPEIKEIIGECICKNKEERYEIKDLLSHAFFAEDTGVRVELAEEDHG 469
Query: 422 SNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAVA 481
S++ALRLWVEDPKKLKGK KDN AIEF+F+LE +TP+EVA EM++SGFFHESD K VA
Sbjct: 470 RKSTIALRLWVEDPKKLKGKPKDNGAIEFTFDLEKETPDEVAQEMIESGFFHESDVKIVA 529
Query: 482 KSIRDRVTPIKKTREK-KPAGCLEERRD--SQCKSMGNVFPQPQNTTLPLAPAQQTGAEC 538
KSIRDRV I+ RE+ PA +E++D S K+ G P T Q E
Sbjct: 530 KSIRDRVALIQWRRERIWPALQPKEQQDVGSPDKARGPPVPLQVQVTYHAQAGQPGPPEP 589
Query: 539 EETEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDT-SSQPSVAYSSNQTMG- 596
EE E DQH LL +S+ D+ ++G S ++SD+ SSQ SV S
Sbjct: 590 EEPEADQH----LLPPTLPTSATSLASDSTFDSGQGSTVYSDSQSSQQSVMLGSLADAAP 645
Query: 597 --SQMVSNIPQAEVNVPGQIYSSQQLVGHYQQVS-----------------GLQKHSKLT 637
+Q V + P +E V Q S +G YQQ + LQ+H
Sbjct: 646 SPAQCVCSPPVSEGPVLPQSLPS---LGAYQQPTAAPGLPVGSVPAPACPPSLQQHFPDP 702
Query: 638 QPQILPLVQGQSTVLPVHVLGPTVVSQPQVSPLTVQKVPQIKPVSQP-VGAEQQAALLKP 696
P++ ST +P GP Q +P Q P +P P V A Q L+P
Sbjct: 703 AMSFAPVLPPPSTPMPT---GP-----GQPAPPGQQPPPLAQPTPLPQVLAPQPVVPLQP 754
Score = 150 bits (378), Expect = 1e-35
Identities = 164/627 (26%), Positives = 258/627 (41%), Gaps = 64/627 (10%)
Query: 519 PQPQNTTLPLAPAQQTGAECEETEVDQHVRQQLLQ-RKPQQHCSSVTGDNLSEAGAASVI 577
PQP P+ P Q VR + LQ P+Q + T + G +
Sbjct: 982 PQPMLPPQPVLPPQPA----------LPVRPEPLQPHLPEQAAPAATPGSQILLGHPAPY 1031
Query: 578 HSDTSSQ-PSVAYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKL 636
D ++Q P+V + + + A + Q SS V Q Q + L
Sbjct: 1032 AVDVAAQVPTVPVPPAAVLSPPLPEVLLPAAPELLPQFPSSLATVSASVQSVPTQT-ATL 1090
Query: 637 TQPQILPLVQGQSTVLPVHVLGPTVVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKP 696
P PL G P PTV Q V P+ ++ Q KP P E
Sbjct: 1091 LPPANPPLPGGPGIASPC----PTV--QLTVEPVQEEQASQDKPPGLPQSCESYGG---- 1140
Query: 697 DLVRSLNQDVATTKENVSSPDNPSGNGKQD----RIKQRRASCPRP--EKGTKFQLTVLQ 750
DV + KE S + G G+ + R RR++ R E+ ++ +LT+L
Sbjct: 1141 -------SDVTSGKELSDSCEGAFGGGRLEGRAARKHHRRSTRARSRQERASRPRLTILN 1193
Query: 751 VSTSGDNMVECQLETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAI 810
V +GD MVECQLETHN+KMVTFKFD+DGDAP++IA YMVE +F+L++E+E F+E+++ +
Sbjct: 1194 VCNTGDKMVECQLETHNHKMVTFKFDLDGDAPDEIATYMVEHDFILQAERETFIEQMKDV 1253
Query: 811 VGQAQEILHVHFATERATGVDSITVDSNSSQTGSSEQVQINSTSTQTSNESAPQSSPVGR 870
+ +A+++L +R + + ++ G+ E+ + + + ++ + R
Sbjct: 1254 MDKAEDMLSEDTDADRGSDPGTSPPHLSTCGLGTGEESRQSQANAPVYQQNVLHTGK--R 1311
Query: 871 WRFCINQTIRNRETQSPPSLQHSMSAVPGRHPLPSPKNTSNKEISRDTL-----LTIENN 925
W F I P +H P P P P ++ E S+D+ L+ +
Sbjct: 1312 W-FII-----------CPVAEHPAPEAPESSP-PLPLSSLPPEASQDSAPYKDQLSSKEQ 1358
Query: 926 PCHRALFTSKSEHKDVVDGKISECASVETKQPAILYQVEDNRQIMAPVTNSSSYSTTSVR 985
P A S+ + + A + P + +D + T S
Sbjct: 1359 PSFLASQQLLSQ-AGPSNPPGAPPAPLAPSSPPVTALPQDGAAPATSTMPEPASGTASQA 1417
Query: 986 AVPAECEGLTKQASIFIPVYPCHQTASQADALMSHPGESTQT-SGNSLTTLAFDQKPQTL 1044
P +GLT + P+ H+ L+ T S + ++P
Sbjct: 1418 GGPGTPQGLTSELETSQPLAETHEAPLAVQPLVVGLAPCTPAPEAASTRDASAPREPLPP 1477
Query: 1045 SVQQPAMDA----EFISQEGETTVNTEASSPKTVIPTQTPGLEPTT-LQPTTVLESDGE- 1098
+P+ + + Q + +P L PT QP + LESDGE
Sbjct: 1478 PAPEPSPHSGTPQPALGQPAPLLPAAVGAVSLATSQLPSPPLGPTVPPQPPSALESDGEG 1537
Query: 1099 RPPKLEFADNRIKTLDEKLRNLLYQEH 1125
PP++ F D+ IK+LDEKLR LLYQEH
Sbjct: 1538 PPPRVGFVDSTIKSLDEKLRTLLYQEH 1564
Score = 71.6 bits (174), Expect = 6e-12
Identities = 43/95 (45%), Positives = 60/95 (63%), Gaps = 20/95 (21%)
Query: 1513 FYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQELYERLRSIKDS 1572
F+S SS +SSD++SE+ED D+K ELQ LREKH++E+ LQ+QQ +E++ LY RL
Sbjct: 1873 FHSQSSYISSDNDSELEDADIKKELQSLREKHLKEISELQSQQKQEIEALYRRLGK---- 1928
Query: 1573 KTQSTEIPLPP-------ASP--RRPRSFKSKLRS 1598
PLPP A P RR ++ KSKL++
Sbjct: 1929 -------PLPPNVGFFHTAPPTGRRRKTSKSKLKA 1956
Score = 63.5 bits (153), Expect = 2e-09
Identities = 40/99 (40%), Positives = 54/99 (54%), Gaps = 8/99 (8%)
Query: 1641 SKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHKLETE---NWNKVSENTPSTM 1697
+KKG FTDDLHKLVD+WT + VG + +KP+LNQLKQ+Q + E W E T
Sbjct: 2116 NKKGTFTDDLHKLVDEWTSKTVGAAQLKPTLNQLKQTQKLQDMEAQAGWAAPGEARAMTA 2175
Query: 1698 GYTSTWISSLSQIRGAVPTSLPQG----LSLPSFPGPLS 1732
+ L G + T++ G LS+P+ P P S
Sbjct: 2176 PRAGVGMPRLPPAPGPLSTTVIPGAAPTLSVPT-PDPES 2213
Score = 32.3 bits (72), Expect = 4.3
Identities = 14/49 (28%), Positives = 27/49 (55%)
Query: 767 NNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQ 815
+N + F FD++ + P+++A M+E F ES+ + + +R V Q
Sbjct: 492 DNGAIEFTFDLEKETPDEVAQEMIESGFFHESDVKIVAKSIRDRVALIQ 540
Score = 32.3 bits (72), Expect = 4.3
Identities = 26/107 (24%), Positives = 49/107 (45%), Gaps = 13/107 (12%)
Query: 444 DNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCL 503
+++ + F F+L+ D P+E+A MV+ F +++ + + ++D + K L
Sbjct: 1210 NHKMVTFKFDLDGDAPDEIATYMVEHDFILQAERETFIEQMKDVM--------DKAEDML 1261
Query: 504 EERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEETEVDQHVRQQ 550
E D+ S P P +T L TG E +++ + V QQ
Sbjct: 1262 SEDTDADRGSDPGTSP-PHLSTCGLG----TGEESRQSQANAPVYQQ 1303
>gi|148612809 WNK lysine deficient protein kinase 1 [Homo sapiens]
Length = 2382
Score = 649 bits (1674), Expect = 0.0
Identities = 386/687 (56%), Positives = 455/687 (66%), Gaps = 54/687 (7%)
Query: 72 AESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDCFKEKNEKEME- 130
A + P + ++ + R PS V G +E S S +K+ +E+++++ +
Sbjct: 147 AVAGPAPSTVPSSTSKDRPVSQPSLV--GSKEEPPPARSGSGGGSAKEPQEERSQQQDDI 204
Query: 131 EEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQR 190
EE E KAV S GRFLKFDIE+GRG+FKTVYKGLDTET VEVAWCELQDRKLTK+E+QR
Sbjct: 205 EELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQR 264
Query: 191 FKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVL 250
FKEEAEMLKGLQHPNIVRFYDSWES +KGKKCIVLVTELMTSGTLKTYLKRFKVMK KVL
Sbjct: 265 FKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVL 324
Query: 251 RSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVI 310
RSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL R SFAKSVI
Sbjct: 325 RSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVI 384
Query: 311 GTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASF 370
GTPEFMAPEMYEE YDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYR+VTSG+KPASF
Sbjct: 385 GTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASF 444
Query: 371 NKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDDCSNSSLALRL 430
+KV PEVKEIIEGCIRQNK ER SI+DLLNHAFF E+TG+RVELAEEDD ++ L L
Sbjct: 445 DKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEETGVRVELAEEDDGEKIAIKLWL 504
Query: 431 WVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTP 490
+ED KKLKGK+KDNEAIEFSF+LE D PE+VA EMV+SG+ E D K +AK+I+DRV+
Sbjct: 505 RIEDIKKLKGKYKDNEAIEFSFDLERDVPEDVAQEMVESGYVCEGDHKTMAKAIKDRVSL 564
Query: 491 IKKTRE------------KKPAGCLEERRDSQCKSMGNVFPQPQ-NTTLPLA----PAQQ 533
IK+ RE K+ L+++ + S + P +T +P A +
Sbjct: 565 IKRKREQRQLVREEQEKKKQEESSLKQQVEQSSASQTGIKQLPSASTGIPTASTTSASVS 624
Query: 534 TGAECEETEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDT--SSQPSVAYSS 591
T E EE E DQH QQL ++P SV D ++G S + +++ SSQ +V+Y S
Sbjct: 625 TQVEPEEPEADQH--QQLQYQQPS---ISVLSDGTVDSGQGSSVFTESRVSSQQTVSYGS 679
Query: 592 NQTMGSQMVSNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTV 651
+ VPG I S+ Q Q G+ S + Q Q QGQ +
Sbjct: 680 QHEQA--------HSTGTVPGHIPSTVQA---QSQPHGVYPPSSVAQGQ----SQGQPS- 723
Query: 652 LPVHVLGPTVVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKE 711
L SQP P Q + Q P Q V + L ++ ATT +
Sbjct: 724 --SSSLTGVSSSQPIQHPQQQQGIQQTAPPQQTV---------QYSLSQTSTSSEATTAQ 772
Query: 712 NVSSPDNPSGNGKQDRIKQRRASCPRP 738
VS P P + KQ S P P
Sbjct: 773 PVSQPQAPQVLPQVSAGKQLPVSQPVP 799
Score = 126 bits (316), Expect = 2e-28
Identities = 237/994 (23%), Positives = 375/994 (37%), Gaps = 237/994 (23%)
Query: 955 KQPAILYQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQA 1014
K PA++ Q + S S +T+ P+ L+ Q S T + A
Sbjct: 1470 KPPAVVSQQAAGSTTVGATLTSVSTTTS----FPSTASQLSIQLS------SSTSTPTLA 1519
Query: 1015 DALMSHPGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEG-------ETTVNTE 1067
+ ++ +TS +S T LAF + S A + +ISQ G + + +
Sbjct: 1520 ETVVVSAHSLDKTSHSSTTGLAFSLSAPSSSSSPGAGVSSYISQPGGLHPLVIPSVIAST 1579
Query: 1068 ASSPKTVIPTQTPGLE-----PTTLQP--------------------------TTVLESD 1096
P+ PT TP L P +QP T E D
Sbjct: 1580 PILPQAAGPTSTPLLPQVPSIPPLVQPVANVPAVQQTLIHSQPQPALLPNQPHTHCPEVD 1639
Query: 1097 GERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQSIDSPFSSSAEDTLSCP 1156
+ PK D+ IKTL+EKLR+L + EHS S +Q + S+++ + T P
Sbjct: 1640 SDTQPKAPGIDD-IKTLEEKLRSL-FSEHSSSG----AQHASVSLETSLVIESTVTPGIP 1693
Query: 1157 VTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVFKRDLNVITSVPSELCL 1216
T V S P G+ L P +S +++ S +
Sbjct: 1694 TTAVAPSKLLTSTTSTCLPPTNLPLGTVALPVTPVVTPGQVST------PVSTTTSGV-- 1745
Query: 1217 HEMSSDASLPGDPEAYPAAVSSGGAIHLQTGGGYFGLSFTCPSLKNPI----SKKSWTRK 1272
+ P P A V G L G T PS + P S +
Sbjct: 1746 ----KPGTAPSKPPLTKAPVLPVGT-ELPAG--------TLPSEQLPPFPGPSLTQSQQP 1792
Query: 1273 LKSWAYRLRQSTSFFKRSKVRQVETEEMRSAIAP----DPIPLTRESTADTRALNRCK-- 1326
L+ +LR++ S E + SA+ P P +T T + +++ K
Sbjct: 1793 LEDLDAQLRRTLS---------PEMITVTSAVGPVSMAAPTAITEAGTQPQKGVSQVKEG 1843
Query: 1327 ------AMSGSFQRGRFQVITIPQ--QQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKS 1378
+ +G F+ GRFQV Q+ K S + + S T+ SS + + +S
Sbjct: 1844 PVLATSSGAGVFKMGRFQVSVAADGAQKEGKNKSEDAKSVHFESSTSESSVLSS-SSPES 1902
Query: 1379 QLVEIEP--------ATQNPKTSFSYEKLQALQETCKENK----GVPKQGDNFLSFSAAC 1426
LV+ EP ++ P+++ +A +T + K V + FS +
Sbjct: 1903 TLVKPEPNGITIPGISSDVPESAHKTTASEAKSDTGQPTKVGRFQVTTTANKVGRFSVS- 1961
Query: 1427 ETDVSSVTPEKEFEETSATGSSMQSG---SELLLKEREILTAGKQ---PSSDSE---FSA 1477
+T+ +KE S ++ + + KE+ L+ PSSD E S
Sbjct: 1962 KTEDKITDTKKEGPVASPPFMDLEQAVLPAVIPKKEKPELSEPSHLNGPSSDPEAAFLSR 2021
Query: 1478 SLAGSGKSVAKTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVEL 1537
+ S S++ LP Q +Q+ S+ F S S MSSD+ES+IEDEDLK+EL
Sbjct: 2022 DVDDGSGSPHSPHQLSSKSLP---SQNLSQSLSNSFNS--SYMSSDNESDIEDEDLKLEL 2076
Query: 1538 QRLREKHIQEVVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASP-----RRPRSF 1592
+RLR+KH++E+ +LQ++Q E++ LY +L + + + +PPA+P RRP
Sbjct: 2077 RRLRDKHLKEIQDLQSRQKHEIESLYTKLGKVPPA------VIIPPAAPLSGRRRRPTKS 2130
Query: 1593 KSKLRSR-------------------------PQSLTHVDNGIVATGKSCLINELE---- 1623
K SR PQ H I +G++ L+ L+
Sbjct: 2131 KGSKSSRSSSLGNKSPQLSGNLSGQSAASVLHPQQTLHPPGNIPESGQNQLLQPLKPSPS 2190
Query: 1624 -----------------------------NPLCVESNAASCQQSP----ASKKGMFTDDL 1650
N + N+ + Q P +S+KG FTDDL
Sbjct: 2191 SDNLYSAFTSDGAISVPSLSAPGQGTSSTNTVGATVNSQAAQAQPPAMTSSRKGTFTDDL 2250
Query: 1651 HKLVDDWTKEAVGNSLIKPSLNQLKQSQHKLETENWNKVSE-NTPSTMGYTSTWISSLSQ 1709
HKLVD+W ++A+ +L+ + S+ + E + + P + IS S
Sbjct: 2251 HKLVDNWARDAM-------NLSGRRGSKGHMNYEGPGMARKFSAPGQL-----CISMTSN 2298
Query: 1710 IRGAVPTSLPQGLSLPSFPG---PLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVV 1766
+ G+ P S SL F P YG P + QW G G Q +
Sbjct: 2299 LGGSAPISAASATSLGHFTKSMCPPQQYGFP---------ATPFGAQWSGTGGPAPQPL- 2348
Query: 1767 IPAQSGGPFQP--GMNMQAFPTSSVQNPATIPPG 1798
G FQP ++Q F S++Q + PPG
Sbjct: 2349 ------GQFQPVGTASLQNFNISNLQKSISNPPG 2376
Score = 112 bits (279), Expect = 4e-24
Identities = 79/198 (39%), Positives = 110/198 (55%), Gaps = 12/198 (6%)
Query: 659 PTVVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDL---VRSLNQDVATT----KE 711
PT SQ V T Q V Q+ P ++PV Q A L V S + DVA+ E
Sbjct: 1027 PTTSSQQAVLEST-QGVSQVAP-AEPVAVAQTQATQPTTLASSVDSAHSDVASGMSDGNE 1084
Query: 712 NV-SSPDNPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKM 770
NV SS G + ++ S R EK ++ +L +L VS GD +VECQLETHN KM
Sbjct: 1085 NVPSSSGRHEGRTTKRHYRKSVRSRSRHEKTSRPKLRILNVSNKGDRVVECQLETHNRKM 1144
Query: 771 VTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEIL--HVHFATERAT 828
VTFKFD+DGD PE+IA MV ++F+L E+E FV+++R I+ +A E+L V E
Sbjct: 1145 VTFKFDLDGDNPEEIATIMVNNDFILAIERESFVDQVREIIEKADEMLSEDVSVEPEGDQ 1204
Query: 829 GVDSITVDSNSSQTGSSE 846
G++S+ + +GS +
Sbjct: 1205 GLESLQGKDDYGFSGSQK 1222
Score = 40.0 bits (92), Expect = 0.020
Identities = 62/284 (21%), Positives = 110/284 (38%), Gaps = 47/284 (16%)
Query: 767 NNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKE-------------KFVEELRAIVGQ 813
+N+ + F FD++ D PED+A MVE +V E + + K E R +V +
Sbjct: 518 DNEAIEFSFDLERDVPEDVAQEMVESGYVCEGDHKTMAKAIKDRVSLIKRKREQRQLVRE 577
Query: 814 AQEILHVHFATERATGVDSITVDSNSSQTGSSEQVQINSTSTQTSNESAPQSSPVGRWRF 873
QE + + + S++SQTG + ++ S SA S+ V
Sbjct: 578 EQE-----KKKQEESSLKQQVEQSSASQTGIKQLPSASTGIPTASTTSASVSTQV----- 627
Query: 874 CINQTIRNRETQSPPSLQHSMSAVPGRHPLPSPKNTSNKEISRDTLLTIENNPCHRALFT 933
E + P + QH + + P S + + + + + E+ + +
Sbjct: 628 ---------EPEEPEADQHQQ--LQYQQPSISVLSDGTVDSGQGSSVFTESRVSSQQTVS 676
Query: 934 SKSEHKD-----VVDGKISECASVETKQPAILYQVEDNRQIMAPVTNSSSYSTTSVRAV- 987
S+H+ V G I ++ QP +Y Q + SSS S T V +
Sbjct: 677 YGSQHEQAHSTGTVPGHIPSTVQAQS-QPHGVYPPSSVAQGQSQGQPSSS-SLTGVSSSQ 734
Query: 988 ----PAECEGLTKQASIFIPV-YPCHQTASQADALMSHPGESTQ 1026
P + +G+ + A V Y QT++ ++A + P Q
Sbjct: 735 PIQHPQQQQGIQQTAPPQQTVQYSLSQTSTSSEATTAQPVSQPQ 778
>gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens]
Length = 1243
Score = 560 bits (1443), Expect = e-159
Identities = 306/514 (59%), Positives = 369/514 (71%), Gaps = 26/514 (5%)
Query: 122 KEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDR 181
+ + E+E +E+ E +AVATSP GR+LKFDIE+GRG+FKTVY+GLDT+T VEVAWCELQ R
Sbjct: 149 ERRREQEEKEDMETQAVATSPDGRYLKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTR 208
Query: 182 KLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKR 241
KL++AE+QRF EE EMLKGLQHPNIVRFYDSW+S+L+G+ CIVLVTELMTSGTLKTYL+R
Sbjct: 209 KLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIVLVTELMTSGTLKTYLRR 268
Query: 242 FKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLM 301
F+ MKP+VL+ W RQIL+GL FLH+R PPI+HRDLKCDN+FITGPTGSVKIGDLGLATL
Sbjct: 269 FREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPTGSVKIGDLGLATLK 328
Query: 302 RTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKV 361
R SFAKSVIGTPEFMAPEMYEE YDE+VDVYAFGMCMLEMATSEYPYSECQNAAQIYRKV
Sbjct: 329 RASFAKSVIGTPEFMAPEMYEEKYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKV 388
Query: 362 TSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDDC 421
TSG KP SF+KV PEVKEIIEGCIR +K+ER +I+DLL HAFF E+ G+ VELAEEDD
Sbjct: 389 TSGRKPNSFHKVKIPEVKEIIEGCIRTDKNERFTIQDLLAHAFFREERGVHVELAEEDDG 448
Query: 422 SNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAVA 481
L L L +ED ++ G+ +DN+AIEF F L D EEVA EMV G E+D + VA
Sbjct: 449 EKPGLKLWLRMEDARR-GGRPRDNQAIEFLFQLGRDAAEEVAQEMVALGLVCEADYQPVA 507
Query: 482 KSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQT--GAECE 539
+++R+RV I++ REK L + R+ + P P T+P+AP + E E
Sbjct: 508 RAVRERVAAIQRKREK-----LRKARELEALPPE---PGPPPATVPMAPGPPSVFPPEPE 559
Query: 540 ETEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQ--------PSVAYSS 591
E E DQH Q L R SS T D ++ +S D S PS S
Sbjct: 560 EPEADQH--QPFLFRHASY--SSTTSDCETDGYLSSSGFLDASDPALQPPGGVPSSLAES 615
Query: 592 NQTMGSQMVSNIPQAEVN---VPGQIYSSQQLVG 622
+ + S +IP++ PG Y+S G
Sbjct: 616 HLCLPSAFALSIPRSGPGSDFSPGDSYASDAASG 649
Score = 94.7 bits (234), Expect = 7e-19
Identities = 99/366 (27%), Positives = 145/366 (39%), Gaps = 57/366 (15%)
Query: 745 QLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFV 804
+L V VS D +VECQL+THN+KMVTF+FD+DGD+PE+IA MV + F+L SE++ F+
Sbjct: 675 RLRVTSVSDQNDRVVECQLQTHNSKMVTFRFDLDGDSPEEIAAAMVYNEFILPSERDGFL 734
Query: 805 EELRAIVGQAQEILHVHFATERATGVDSITVDSNSSQTGSSEQVQINSTSTQTSNESAPQ 864
+R I+ + + +L +R TG D+ S Q + + SNE
Sbjct: 735 RRIREIIQRVETLL------KRDTGPMEAAEDTLSPQEEPAPLPALPVPLPDPSNE---- 784
Query: 865 SSPVGRWRFCINQTIRNRETQSPPSLQH-------SMSAVPGRHPLPSPKNTSNKEISRD 917
E QS SL+H + S+ PG P + IS
Sbjct: 785 ------------------ELQSSTSLEHRSWTAFSTSSSSPGTPLSPGNPFSPGTPISPG 826
Query: 918 TLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAILYQVEDNRQIMAPVTNSS 977
+ I + PCH S S + S + T P + S
Sbjct: 827 PIFPITSPPCH----PSPSPFSPISSQVSSNPSPHPTSSPLPFSSSTPEFPVPLSQCPWS 882
Query: 978 SYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSHPGESTQTSGNSLTTLAF 1037
S TTS C +T +S F P PC T+S T+ L +LA
Sbjct: 883 SLPTTSPPTFSPTCSQVT-LSSPFFP--PCPSTSS-----------FPSTTAAPLLSLAS 928
Query: 1038 DQKPQTLSVQQPAMDAE--FISQEGETTVNTEASSPKTVIPTQTPGLEPTTLQPTTVLES 1095
++V Q + +SQ + S P + P PG + + T +ES
Sbjct: 929 AFSLAVMTVAQSLLSPSPGLLSQSPPAPPSPLPSLP--LPPPVAPGGQESPSPHTAEVES 986
Query: 1096 DGERPP 1101
+ PP
Sbjct: 987 EASPPP 992
Score = 54.7 bits (130), Expect = 8e-07
Identities = 44/148 (29%), Positives = 64/148 (43%), Gaps = 19/148 (12%)
Query: 1421 SFSAACETDVSSVTPEKEFEETSATGSSMQSGSELLLKER--EILTAGKQPSSDSEFSAS 1478
+ S + + +T E E SA G ++ L +R E L AG + D
Sbjct: 1037 TLSGSPKPSTPQLTSESSDTEDSA-GGGPETREALAESDRAAEGLGAGVEEEGDDGKEPQ 1095
Query: 1479 LAGSGKSVAKTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQ 1538
+ GS + ++ P + YS S + ES EDE+ ELQ
Sbjct: 1096 VGGSPQPLSHPSP----------------VWMNYSYSSLCLSSEESESSGEDEEFWAELQ 1139
Query: 1539 RLREKHIQEVVNLQTQQNKELQELYERL 1566
LR+KH+ EV LQT Q KE+++LY RL
Sbjct: 1140 SLRQKHLSEVETLQTLQKKEIEDLYSRL 1167
Score = 38.9 bits (89), Expect = 0.046
Identities = 26/99 (26%), Positives = 47/99 (47%), Gaps = 8/99 (8%)
Query: 444 DNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCL 503
+++ + F F+L+ D+PEE+A MV + F S+ + IR+ + + +T K+ G +
Sbjct: 697 NSKMVTFRFDLDGDSPEEIAAAMVYNEFILPSERDGFLRRIREIIQRV-ETLLKRDTGPM 755
Query: 504 EERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEETE 542
E D+ + PQ + LP P EE +
Sbjct: 756 EAAEDT-------LSPQEEPAPLPALPVPLPDPSNEELQ 787
>gi|7019333 nuclear receptor binding protein [Homo sapiens]
Length = 535
Score = 153 bits (386), Expect = 2e-36
Identities = 108/334 (32%), Positives = 164/334 (49%), Gaps = 24/334 (7%)
Query: 97 VLRGGQEVKYEQCSKS------TSEISKDCFKEKNEKEMEEEAEMKAVATSPSGRFLKFD 150
VL G + K E S + + ++ E+E E E E + + SP GR+ K
Sbjct: 9 VLSSGSDPKVESSSSAPGLTSVSPPVTSTTSAASPEEEEESEDESEILEESPCGRWQKRR 68
Query: 151 IELGRG---AFKTVYKGLDTETWVEVAWCELQ--DRKLTKAEQQRFKEEAEMLKGLQHPN 205
E+ + + Y +DTE VEV W E+Q +RK K ++++ + + L L+H N
Sbjct: 69 EEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNLIQLEHLN 128
Query: 206 IVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKR----FKVMKPKVLRSWCRQILKGL 261
IV+F+ W I + K ++ +TE M+SG+LK +LK+ K M K + WC QIL L
Sbjct: 129 IVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSAL 188
Query: 262 QFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL-MRTSFAKSVIGTPEFMAPEM 320
+LH+ PPIIH +L CD IFI G +KIG + T+ + F APE
Sbjct: 189 SYLHSCDPPIIHGNLTCDTIFIQ-HNGLIKIGSVAPDTINNHVKTCREEQKNLHFFAPEY 247
Query: 321 YE-EHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVK 379
E + +VD+Y+FGMC LEMA E N Y V ++ + DP +
Sbjct: 248 GEVTNVTTAVDIYSFGMCALEMAVLEIQ----GNGESSY--VPQEAISSAIQLLEDPLQR 301
Query: 380 EIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRV 413
E I+ C++ + R + R+LL H E L++
Sbjct: 302 EFIQKCLQSEPARRPTARELLFHPALFEVPSLKL 335
>gi|148839316 NIMA-related kinase 4 [Homo sapiens]
Length = 841
Score = 122 bits (306), Expect = 3e-27
Identities = 79/248 (31%), Positives = 133/248 (53%), Gaps = 20/248 (8%)
Query: 177 ELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLK 236
+L R + E++ ++EA++L L+HPNIV + +SWE G + +V G L
Sbjct: 36 KLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEG---GDGLLYIVMGFCEGGDLY 92
Query: 237 TYLKRFK--VMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGD 294
LK K ++ + W QI LQ+LH + I+HRDLK N+F+T T +K+GD
Sbjct: 93 RKLKEQKGQLLPENQVVEWFVQIAMALQYLHEK--HILHRDLKTQNVFLT-RTNIIKVGD 149
Query: 295 LGLATLMRT--SFAKSVIGTPEFMAPEMY-EEHYDESVDVYAFGMCMLEMATSEYPYSEC 351
LG+A ++ A ++IGTP +M+PE++ + Y+ DV+A G C+ EMAT ++ ++
Sbjct: 150 LGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAK 209
Query: 352 QNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNH-------AF 404
+ +YR + + P + PE+ E+I + + ER S+R +L +F
Sbjct: 210 DMNSLVYRIIEGKLPP--MPRDYSPELAELIRTMLSKRPEERPSVRSILRQPYIKRQISF 267
Query: 405 FAEDTGLR 412
F E T ++
Sbjct: 268 FLEATKIK 275
>gi|42794767 mitogen-activated protein kinase kinase kinase 3
isoform 1 [Homo sapiens]
Length = 657
Score = 120 bits (301), Expect = 1e-26
Identities = 82/261 (31%), Positives = 139/261 (53%), Gaps = 16/261 (6%)
Query: 153 LGRGAFKTVYKGLDTETWVEVAWCELQ---DRKLTKAEQQRFKEEAEMLKGLQHPNIVRF 209
LG+GAF VY D +T E+A ++Q D T E + E ++LK LQH IV++
Sbjct: 399 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQY 458
Query: 210 YDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTP 269
Y + +K + + E M G++K LK + + V R + RQIL+G+ +LH+
Sbjct: 459 YGCLRD--RAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNM- 515
Query: 270 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRT-----SFAKSVIGTPEFMAPEMYE-E 323
I+HRD+K NI + G+VK+GD G + ++T + +SV GTP +M+PE+ E
Sbjct: 516 -IVHRDIKGANI-LRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGE 573
Query: 324 HYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIE 383
Y DV++ G ++EM T + P++E + A I++ T P + +++ ++ +
Sbjct: 574 GYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISE-HGRDFLR 632
Query: 384 GCIRQNKSERLSIRDLLNHAF 404
+ + +R S +LL H F
Sbjct: 633 RIFVEAR-QRPSAEELLTHHF 652
>gi|42794765 mitogen-activated protein kinase kinase kinase 3
isoform 2 [Homo sapiens]
Length = 626
Score = 120 bits (301), Expect = 1e-26
Identities = 82/261 (31%), Positives = 139/261 (53%), Gaps = 16/261 (6%)
Query: 153 LGRGAFKTVYKGLDTETWVEVAWCELQ---DRKLTKAEQQRFKEEAEMLKGLQHPNIVRF 209
LG+GAF VY D +T E+A ++Q D T E + E ++LK LQH IV++
Sbjct: 368 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQY 427
Query: 210 YDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTP 269
Y + +K + + E M G++K LK + + V R + RQIL+G+ +LH+
Sbjct: 428 YGCLRD--RAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNM- 484
Query: 270 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRT-----SFAKSVIGTPEFMAPEMYE-E 323
I+HRD+K NI + G+VK+GD G + ++T + +SV GTP +M+PE+ E
Sbjct: 485 -IVHRDIKGANI-LRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGE 542
Query: 324 HYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIE 383
Y DV++ G ++EM T + P++E + A I++ T P + +++ ++ +
Sbjct: 543 GYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISE-HGRDFLR 601
Query: 384 GCIRQNKSERLSIRDLLNHAF 404
+ + +R S +LL H F
Sbjct: 602 RIFVEAR-QRPSAEELLTHHF 621
>gi|32483399 p21-activated kinase 2 [Homo sapiens]
Length = 524
Score = 120 bits (300), Expect = 2e-26
Identities = 97/343 (28%), Positives = 161/343 (46%), Gaps = 20/343 (5%)
Query: 71 VAESSPKDERIKAAMNIPRVDKLPSNVLRGGQE-VKYEQCSKSTSEISKDCFKEKNEKEM 129
V E DE + PR D S R + V +K K+K + +M
Sbjct: 168 VTEEEDDDEETAPPVIAPRPDHTKSIYTRSVIDPVPAPVGDSHVDGAAKSLDKQKKKTKM 227
Query: 130 EEEAEMKAVAT-----SPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLT 184
+E M+ + T P ++ +++ ++G+GA TV+ D EVA ++ +K
Sbjct: 228 TDEEIMEKLRTIVSIGDPKKKYTRYE-KIGQGASGTVFTATDVALGQEVAIKQINLQKQP 286
Query: 185 KAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKV 244
K E E ++K L++PNIV F DS+ L G + V V E + G+L +
Sbjct: 287 KKEL--IINEILVMKELKNPNIVNFLDSY---LVGDELFV-VMEYLAGGSLTDVVTE-TC 339
Query: 245 MKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTS 304
M + + CR+ L+ L+FLH +IHRD+K DN+ + G GSVK+ D G +
Sbjct: 340 MDEAQIAAVCRECLQALEFLHANQ--VIHRDIKSDNVLL-GMEGSVKLTDFGFCAQITPE 396
Query: 305 FAK--SVIGTPEFMAPEMY-EEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKV 361
+K +++GTP +MAPE+ + Y VD+++ G+ +EM E PY +Y
Sbjct: 397 QSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIA 456
Query: 362 TSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAF 404
T+G + P ++ + C+ + +R S ++LL H F
Sbjct: 457 TNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPF 499
>gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Homo
sapiens]
Length = 619
Score = 115 bits (289), Expect = 3e-25
Identities = 84/261 (32%), Positives = 136/261 (52%), Gaps = 16/261 (6%)
Query: 153 LGRGAFKTVYKGLDTETWVEVAWCELQ---DRKLTKAEQQRFKEEAEMLKGLQHPNIVRF 209
LG+GAF VY D +T E+A ++Q D T E + E ++LK L H IV++
Sbjct: 362 LGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQY 421
Query: 210 YDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTP 269
Y +K + + E M G++K LK + + V R + RQIL+G+ +LH+
Sbjct: 422 YGCLRD--PQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNM- 478
Query: 270 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRT-----SFAKSVIGTPEFMAPEMYE-E 323
I+HRD+K NI + TG+VK+GD G + ++T + KSV GTP +M+PE+ E
Sbjct: 479 -IVHRDIKGANI-LRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGE 536
Query: 324 HYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIE 383
Y D+++ ++EM T + P++E + A I++ T P V+D ++ ++
Sbjct: 537 GYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSD-YTRDFLK 595
Query: 384 GCIRQNKSERLSIRDLLNHAF 404
+ K R S +LL H F
Sbjct: 596 RIFVEAKL-RPSADELLRHMF 615
>gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]
Length = 545
Score = 114 bits (285), Expect = 9e-25
Identities = 90/341 (26%), Positives = 166/341 (48%), Gaps = 22/341 (6%)
Query: 75 SPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSE---ISKDCFKEKNEKEMEE 131
+P+ E K+ ++ LP R +T+ ++++ K+K + +M +
Sbjct: 191 APRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSD 250
Query: 132 EAEMKAVAT-----SPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKA 186
E ++ + + P ++ +F+ ++G+GA TVY +D T EVA ++ ++ K
Sbjct: 251 EEILEKLRSIVSVGDPKKKYTRFE-KIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKK 309
Query: 187 EQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMK 246
E E +++ ++PNIV + DS+ L G + V V E + G+L + M
Sbjct: 310 EL--IINEILVMRENKNPNIVNYLDSY---LVGDELWV-VMEYLAGGSLTDVVTE-TCMD 362
Query: 247 PKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFA 306
+ + CR+ L+ L+FLH+ +IHRD+K DNI + G GSVK+ D G + +
Sbjct: 363 EGQIAAVCRECLQALEFLHSNQ--VIHRDIKSDNILL-GMDGSVKLTDFGFCAQITPEQS 419
Query: 307 K--SVIGTPEFMAPEMY-EEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTS 363
K +++GTP +MAPE+ + Y VD+++ G+ +EM E PY +Y T+
Sbjct: 420 KRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATN 479
Query: 364 GIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAF 404
G + ++ + C+ + +R S ++LL H F
Sbjct: 480 GTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQF 520
>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
Length = 559
Score = 113 bits (283), Expect = 1e-24
Identities = 90/349 (25%), Positives = 169/349 (48%), Gaps = 19/349 (5%)
Query: 64 EMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDCFKE 123
E E++ +P+ E K+ V+ + S + + + ++S + ++ ++
Sbjct: 196 EEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQ 255
Query: 124 KNEKEMEEEAEMKAVAT-----SPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCEL 178
+ + +M +E ++ + + P ++ +F+ ++G+GA TVY LD T EVA ++
Sbjct: 256 RKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE-KIGQGASGTVYTALDIATGQEVAIKQM 314
Query: 179 QDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTY 238
++ K E E +++ ++PNIV + DS+ L G + V V E + G+L
Sbjct: 315 NLQQQPKKEL--IINEILVMRENKNPNIVNYLDSY---LVGDELWV-VMEYLAGGSLTDV 368
Query: 239 LKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLA 298
+ M + + CR+ L+ L FLH+ +IHRD+K DNI + G GSVK+ D G
Sbjct: 369 VTE-TCMDEGQIAAVCRECLQALDFLHSNQ--VIHRDIKSDNILL-GMDGSVKLTDFGFC 424
Query: 299 TLMRTSFAK--SVIGTPEFMAPEMY-EEHYDESVDVYAFGMCMLEMATSEYPYSECQNAA 355
+ +K +++GTP +MAPE+ + Y VD+++ G+ +EM E PY
Sbjct: 425 AQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLR 484
Query: 356 QIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAF 404
+Y T+G + ++ + C+ + R S ++LL H F
Sbjct: 485 ALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPF 533
>gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
Length = 565
Score = 113 bits (283), Expect = 1e-24
Identities = 90/349 (25%), Positives = 169/349 (48%), Gaps = 19/349 (5%)
Query: 64 EMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDCFKE 123
E E++ +P+ E K+ V+ + S + + + ++S + ++ ++
Sbjct: 202 EEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQ 261
Query: 124 KNEKEMEEEAEMKAVAT-----SPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCEL 178
+ + +M +E ++ + + P ++ +F+ ++G+GA TVY LD T EVA ++
Sbjct: 262 RKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE-KIGQGASGTVYTALDIATGQEVAIKQM 320
Query: 179 QDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTY 238
++ K E E +++ ++PNIV + DS+ L G + V V E + G+L
Sbjct: 321 NLQQQPKKEL--IINEILVMRENKNPNIVNYLDSY---LVGDELWV-VMEYLAGGSLTDV 374
Query: 239 LKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLA 298
+ M + + CR+ L+ L FLH+ +IHRD+K DNI + G GSVK+ D G
Sbjct: 375 VTE-TCMDEGQIAAVCRECLQALDFLHSNQ--VIHRDIKSDNILL-GMDGSVKLTDFGFC 430
Query: 299 TLMRTSFAK--SVIGTPEFMAPEMY-EEHYDESVDVYAFGMCMLEMATSEYPYSECQNAA 355
+ +K +++GTP +MAPE+ + Y VD+++ G+ +EM E PY
Sbjct: 431 AQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLR 490
Query: 356 QIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAF 404
+Y T+G + ++ + C+ + R S ++LL H F
Sbjct: 491 ALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPF 539
>gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]
Length = 580
Score = 113 bits (283), Expect = 1e-24
Identities = 90/349 (25%), Positives = 169/349 (48%), Gaps = 19/349 (5%)
Query: 64 EMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDCFKE 123
E E++ +P+ E K+ V+ + S + + + ++S + ++ ++
Sbjct: 217 EEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQ 276
Query: 124 KNEKEMEEEAEMKAVAT-----SPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCEL 178
+ + +M +E ++ + + P ++ +F+ ++G+GA TVY LD T EVA ++
Sbjct: 277 RKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE-KIGQGASGTVYTALDIATGQEVAIKQM 335
Query: 179 QDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTY 238
++ K E E +++ ++PNIV + DS+ L G + V V E + G+L
Sbjct: 336 NLQQQPKKEL--IINEILVMRENKNPNIVNYLDSY---LVGDELWV-VMEYLAGGSLTDV 389
Query: 239 LKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLA 298
+ M + + CR+ L+ L FLH+ +IHRD+K DNI + G GSVK+ D G
Sbjct: 390 VTE-TCMDEGQIAAVCRECLQALDFLHSNQ--VIHRDIKSDNILL-GMDGSVKLTDFGFC 445
Query: 299 TLMRTSFAK--SVIGTPEFMAPEMY-EEHYDESVDVYAFGMCMLEMATSEYPYSECQNAA 355
+ +K +++GTP +MAPE+ + Y VD+++ G+ +EM E PY
Sbjct: 446 AQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLR 505
Query: 356 QIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAF 404
+Y T+G + ++ + C+ + R S ++LL H F
Sbjct: 506 ALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPF 554
>gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 113 bits (283), Expect = 1e-24
Identities = 90/349 (25%), Positives = 169/349 (48%), Gaps = 19/349 (5%)
Query: 64 EMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDCFKE 123
E E++ +P+ E K+ V+ + S + + + ++S + ++ ++
Sbjct: 181 EEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQ 240
Query: 124 KNEKEMEEEAEMKAVAT-----SPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCEL 178
+ + +M +E ++ + + P ++ +F+ ++G+GA TVY LD T EVA ++
Sbjct: 241 RKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE-KIGQGASGTVYTALDIATGQEVAIKQM 299
Query: 179 QDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTY 238
++ K E E +++ ++PNIV + DS+ L G + V V E + G+L
Sbjct: 300 NLQQQPKKEL--IINEILVMRENKNPNIVNYLDSY---LVGDELWV-VMEYLAGGSLTDV 353
Query: 239 LKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLA 298
+ M + + CR+ L+ L FLH+ +IHRD+K DNI + G GSVK+ D G
Sbjct: 354 VTE-TCMDEGQIAAVCRECLQALDFLHSNQ--VIHRDIKSDNILL-GMDGSVKLTDFGFC 409
Query: 299 TLMRTSFAK--SVIGTPEFMAPEMY-EEHYDESVDVYAFGMCMLEMATSEYPYSECQNAA 355
+ +K +++GTP +MAPE+ + Y VD+++ G+ +EM E PY
Sbjct: 410 AQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLR 469
Query: 356 QIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAF 404
+Y T+G + ++ + C+ + R S ++LL H F
Sbjct: 470 ALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPF 518
>gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 113 bits (283), Expect = 1e-24
Identities = 90/349 (25%), Positives = 169/349 (48%), Gaps = 19/349 (5%)
Query: 64 EMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDCFKE 123
E E++ +P+ E K+ V+ + S + + + ++S + ++ ++
Sbjct: 181 EEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQ 240
Query: 124 KNEKEMEEEAEMKAVAT-----SPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCEL 178
+ + +M +E ++ + + P ++ +F+ ++G+GA TVY LD T EVA ++
Sbjct: 241 RKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE-KIGQGASGTVYTALDIATGQEVAIKQM 299
Query: 179 QDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTY 238
++ K E E +++ ++PNIV + DS+ L G + V V E + G+L
Sbjct: 300 NLQQQPKKEL--IINEILVMRENKNPNIVNYLDSY---LVGDELWV-VMEYLAGGSLTDV 353
Query: 239 LKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLA 298
+ M + + CR+ L+ L FLH+ +IHRD+K DNI + G GSVK+ D G
Sbjct: 354 VTE-TCMDEGQIAAVCRECLQALDFLHSNQ--VIHRDIKSDNILL-GMDGSVKLTDFGFC 409
Query: 299 TLMRTSFAK--SVIGTPEFMAPEMY-EEHYDESVDVYAFGMCMLEMATSEYPYSECQNAA 355
+ +K +++GTP +MAPE+ + Y VD+++ G+ +EM E PY
Sbjct: 410 AQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLR 469
Query: 356 QIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAF 404
+Y T+G + ++ + C+ + R S ++LL H F
Sbjct: 470 ALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPF 518
>gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 113 bits (283), Expect = 1e-24
Identities = 90/349 (25%), Positives = 169/349 (48%), Gaps = 19/349 (5%)
Query: 64 EMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDCFKE 123
E E++ +P+ E K+ V+ + S + + + ++S + ++ ++
Sbjct: 181 EEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQ 240
Query: 124 KNEKEMEEEAEMKAVAT-----SPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCEL 178
+ + +M +E ++ + + P ++ +F+ ++G+GA TVY LD T EVA ++
Sbjct: 241 RKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE-KIGQGASGTVYTALDIATGQEVAIKQM 299
Query: 179 QDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTY 238
++ K E E +++ ++PNIV + DS+ L G + V V E + G+L
Sbjct: 300 NLQQQPKKEL--IINEILVMRENKNPNIVNYLDSY---LVGDELWV-VMEYLAGGSLTDV 353
Query: 239 LKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLA 298
+ M + + CR+ L+ L FLH+ +IHRD+K DNI + G GSVK+ D G
Sbjct: 354 VTE-TCMDEGQIAAVCRECLQALDFLHSNQ--VIHRDIKSDNILL-GMDGSVKLTDFGFC 409
Query: 299 TLMRTSFAK--SVIGTPEFMAPEMY-EEHYDESVDVYAFGMCMLEMATSEYPYSECQNAA 355
+ +K +++GTP +MAPE+ + Y VD+++ G+ +EM E PY
Sbjct: 410 AQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLR 469
Query: 356 QIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAF 404
+Y T+G + ++ + C+ + R S ++LL H F
Sbjct: 470 ALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPF 518
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 111 bits (278), Expect = 6e-24
Identities = 83/271 (30%), Positives = 138/271 (50%), Gaps = 16/271 (5%)
Query: 153 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDS 212
+G G+F VYKG + VA + ++ E + + E E+++GL+HPNIV DS
Sbjct: 10 IGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHPNIVHMLDS 69
Query: 213 WESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPII 272
+E+ K +V+VT+ G L L+ + +++ Q++ L +LH+ I+
Sbjct: 70 FET----DKEVVVVTD-YAEGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHR--IL 122
Query: 273 HRDLKCDNIFITGPTGSVKIGDLGLATLMRTS--FAKSVIGTPEFMAPEMYEEH-YDESV 329
HRD+K NI + G +K+ D G A M T+ S+ GTP +M+PE+ EE YD +
Sbjct: 123 HRDMKPQNILL-AKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHTA 181
Query: 330 DVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIK-PASFNKVTDPEVKEIIEGCIRQ 388
D+++ G + E+A P+ A I++ V+ +K P + P K ++G + +
Sbjct: 182 DLWSVGCILYELAVGTPPF----YATSIFQLVSLILKDPVRWPSTISPCFKNFLQGLLTK 237
Query: 389 NKSERLSIRDLLNHAFFAEDTGLRVELAEED 419
+ +RLS DLL H F A + E A D
Sbjct: 238 DPRQRLSWPDLLYHPFIAGHVTIITEPAGPD 268
>gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo
sapiens]
Length = 1328
Score = 111 bits (277), Expect = 7e-24
Identities = 82/297 (27%), Positives = 149/297 (50%), Gaps = 25/297 (8%)
Query: 121 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETW---VEVAWCE 177
F NEK++ E +K+ + K +I LG+GA+ TVY GL ++ V+ +
Sbjct: 1039 FLISNEKKIFSENSLKSEEPI---LWTKGEI-LGKGAYGTVYCGLTSQGQLIAVKQVALD 1094
Query: 178 LQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKT 237
++ + E ++ +EE ++LK L+H NIV + + + + + E + G++ +
Sbjct: 1095 TSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQ----ENTVSIFMEFVPGGSISS 1150
Query: 238 YLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGL 297
+ RF + V + +QIL+G+ +LH ++HRD+K +N+ + PTG +K+ D G
Sbjct: 1151 IINRFGPLPEMVFCKYTKQILQGVAYLHENC--VVHRDIKGNNVMLM-PTGIIKLIDFGC 1207
Query: 298 ATLM--------RTSFAKSVIGTPEFMAPEMYEEH-YDESVDVYAFGMCMLEMATSEYPY 348
A + + KS+ GTP +MAPE+ E Y D+++ G + EMAT + P
Sbjct: 1208 ARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPL 1267
Query: 349 SECQN-AAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAF 404
+ AA Y G+ P + ++ + + C+ +++ ER S LL H+F
Sbjct: 1268 ASMDRMAAMFYIGAHRGLMPPLPDHFSE-NAADFVRMCLTRDQHERPSALQLLKHSF 1323
>gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo
sapiens]
Length = 510
Score = 111 bits (277), Expect = 7e-24
Identities = 82/297 (27%), Positives = 149/297 (50%), Gaps = 25/297 (8%)
Query: 121 FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETW---VEVAWCE 177
F NEK++ E +K+ + K +I LG+GA+ TVY GL ++ V+ +
Sbjct: 221 FLISNEKKIFSENSLKSEEPI---LWTKGEI-LGKGAYGTVYCGLTSQGQLIAVKQVALD 276
Query: 178 LQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKT 237
++ + E ++ +EE ++LK L+H NIV + + + + + E + G++ +
Sbjct: 277 TSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQ----ENTVSIFMEFVPGGSISS 332
Query: 238 YLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGL 297
+ RF + V + +QIL+G+ +LH ++HRD+K +N+ + PTG +K+ D G
Sbjct: 333 IINRFGPLPEMVFCKYTKQILQGVAYLHENC--VVHRDIKGNNVMLM-PTGIIKLIDFGC 389
Query: 298 ATLM--------RTSFAKSVIGTPEFMAPEMYEEH-YDESVDVYAFGMCMLEMATSEYPY 348
A + + KS+ GTP +MAPE+ E Y D+++ G + EMAT + P
Sbjct: 390 ARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPL 449
Query: 349 SECQN-AAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAF 404
+ AA Y G+ P + ++ + + C+ +++ ER S LL H+F
Sbjct: 450 ASMDRMAAMFYIGAHRGLMPPLPDHFSE-NAADFVRMCLTRDQHERPSALQLLKHSF 505
>gi|19424132 NIMA-related kinase 7 [Homo sapiens]
Length = 302
Score = 110 bits (275), Expect = 1e-23
Identities = 81/256 (31%), Positives = 136/256 (53%), Gaps = 18/256 (7%)
Query: 148 KFDIELGRGAFKTVYKGLDTETWVEVAWCELQ--DRKLTKAEQQRFKEEAEMLKGLQHPN 205
+ + ++GRG F VY+ V VA ++Q D KA KE ++LK L HPN
Sbjct: 35 RIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKE-IDLLKQLNHPN 93
Query: 206 IVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMK----PKVLRSWCRQILKGL 261
++++Y S+ I + IVL EL +G L +K FK K + + + Q+ L
Sbjct: 94 VIKYYASF--IEDNELNIVL--ELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSAL 149
Query: 262 QFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLM--RTSFAKSVIGTPEFMAPE 319
+ +H+R ++HRD+K N+FIT TG VK+GDLGL +T+ A S++GTP +M+PE
Sbjct: 150 EHMHSRR--VMHRDIKPANVFITA-TGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPE 206
Query: 320 -MYEEHYDESVDVYAFGMCMLEMATSEYP-YSECQNAAQIYRKVTSGIKPASFNKVTDPE 377
++E Y+ D+++ G + EMA + P Y + N + +K+ P + E
Sbjct: 207 RIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEE 266
Query: 378 VKEIIEGCIRQNKSER 393
+++++ CI + +R
Sbjct: 267 LRQLVNMCINPDPEKR 282
>gi|4507831 Unc-51-like kinase 1 [Homo sapiens]
Length = 1050
Score = 109 bits (273), Expect = 2e-23
Identities = 78/273 (28%), Positives = 135/273 (49%), Gaps = 22/273 (8%)
Query: 153 LGRGAFKTVYKGLDTETW-VEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 211
+G GAF V+KG E +EVA + + L K+ Q +E ++LK L+H NIV YD
Sbjct: 22 IGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKS-QTLLGKEIKILKELKHENIVALYD 80
Query: 212 SWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPI 271
E + LV E G L YL + + +R + +QI ++ LH++ I
Sbjct: 81 FQEMA----NSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKG--I 134
Query: 272 IHRDLKCDNIFITGPTG--------SVKIGDLGLATLMRTS-FAKSVIGTPEFMAPE-MY 321
IHRDLK NI ++ P G VKI D G A ++++ A ++ G+P +MAPE +
Sbjct: 135 IHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIM 194
Query: 322 EEHYDESVDVYAFGMCMLEMATSEYPY--SECQNAAQIYRKVTSGIKPASFNKVTDPEVK 379
+HYD D+++ G + + T + P+ S Q+ Y K + + + + T ++
Sbjct: 195 SQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLV--PTIPRETSAPLR 252
Query: 380 EIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLR 412
+++ +++N +R+ + +H F +R
Sbjct: 253 QLLLALLQRNHKDRMDFDEFFHHPFLDASPSVR 285
>gi|150456432 unc-51-like kinase 3 [Homo sapiens]
Length = 472
Score = 109 bits (273), Expect = 2e-23
Identities = 83/296 (28%), Positives = 145/296 (48%), Gaps = 25/296 (8%)
Query: 153 LGRGAFKTVYKGLDTETWVEVAWCELQDRK-LTKAEQQRFKEEAEMLKGLQHPNIVRFYD 211
LG G + TVYK + EV + +K L KA + E E+LKG++HP+IV+ D
Sbjct: 20 LGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQLKD 79
Query: 212 -SWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPP 270
W+S I L+ E G L ++ +++ KV R + +Q+ LQFLH R
Sbjct: 80 FQWDS-----DNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERN-- 132
Query: 271 IIHRDLKCDNIFITG-PTGSVKIGDLGLATLMRTSFAKSVI-GTPEFMAPEMY-EEHYDE 327
I H DLK NI ++ +K+ D G A M K V+ G+P +MAPEM + YD
Sbjct: 133 ISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQYDA 192
Query: 328 SVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSG-IKPASFNKVTDPEVKEIIEGCI 386
VD+++ G+ + E + P++ ++ +++ K+ S + + + +++++ +
Sbjct: 193 RVDLWSMGVILYEALFGQPPFAS-RSFSELEEKIRSNRVIELPLRPLLSRDCRDLLQRLL 251
Query: 387 RQNKSERLSIRDLLNHAF-----------FAEDTGLRVELAEEDDCSNSSLALRLW 431
++ S R+S +D H + T L V+ ++D +S+ AL L+
Sbjct: 252 ERDPSRRISFQDFFAHPWVDLEHMPSGESLGRATALVVQAVKKDQEGDSAAALSLY 307
>gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]
Length = 553
Score = 109 bits (272), Expect = 3e-23
Identities = 88/337 (26%), Positives = 164/337 (48%), Gaps = 22/337 (6%)
Query: 75 SPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSE---ISKDCFKEKNEKEMEE 131
+P+ E K+ ++ LP R +T+ ++++ K+K + +M +
Sbjct: 191 APRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSD 250
Query: 132 EAEMKAVAT-----SPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKA 186
E ++ + + P ++ +F+ ++G+GA TVY +D T EVA ++ ++ K
Sbjct: 251 EEILEKLRSIVSVGDPKKKYTRFE-KIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKK 309
Query: 187 EQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMK 246
E E +++ ++PNIV + DS+ L G + V V E + G+L + M
Sbjct: 310 EL--IINEILVMRENKNPNIVNYLDSY---LVGDELWV-VMEYLAGGSLTDVVTE-TCMD 362
Query: 247 PKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFA 306
+ + CR+ L+ L+FLH+ +IHRD+K DNI + G GSVK+ D G + +
Sbjct: 363 EGQIAAVCRECLQALEFLHSNQ--VIHRDIKSDNILL-GMDGSVKLTDFGFCAQITPEQS 419
Query: 307 K--SVIGTPEFMAPEMY-EEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTS 363
K +++GTP +MAPE+ + Y VD+++ G+ +EM E PY +Y T+
Sbjct: 420 KRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATN 479
Query: 364 GIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLL 400
G + ++ + C+ + +R S ++LL
Sbjct: 480 GTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELL 516
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 107 bits (268), Expect = 8e-23
Identities = 81/289 (28%), Positives = 151/289 (52%), Gaps = 18/289 (6%)
Query: 135 MKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEE 194
M+ + P F K + ++G+G+F V+KG+D T VA ++ D + + E + ++E
Sbjct: 13 MQNLKADPEELFTKLE-KIGKGSFGEVFKGIDNRTQKVVA-IKIIDLEEAEDEIEDIQQE 70
Query: 195 AEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWC 254
+L P + ++Y S+ LK K + ++ E + G+ L+ + + ++ +
Sbjct: 71 ITVLSQCDSPYVTKYYGSY---LKDTK-LWIIMEYLGGGSALDLLEPGPLDETQIA-TIL 125
Query: 255 RQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAK--SVIGT 312
R+ILKGL +LH+ IHRD+K N+ ++ G VK+ D G+A + + K + +GT
Sbjct: 126 REILKGLDYLHSEKK--IHRDIKAANVLLS-EHGEVKLADFGVAGQLTDTQIKRNTFVGT 182
Query: 313 PEFMAPEMYEEH-YDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFN 371
P +MAPE+ ++ YD D+++ G+ +E+A E P+SE + ++ + P
Sbjct: 183 PFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSEL-HPMKVLFLIPKNNPPTLEG 241
Query: 372 KVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFF---AEDTGLRVELAE 417
+ P +KE +E C+ + S R + ++LL H F A+ T EL +
Sbjct: 242 NYSKP-LKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELID 289
>gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]
Length = 347
Score = 107 bits (267), Expect = 1e-22
Identities = 86/261 (32%), Positives = 138/261 (52%), Gaps = 22/261 (8%)
Query: 149 FDIE--LGRGAFKTVYKG---LDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQH 203
F IE +GRG F VYK LD +T V + ++ + KA Q KE +LK L H
Sbjct: 79 FQIEKKIGRGQFSEVYKATCLLDRKT-VALKKVQIFEMMDAKARQDCVKEIG-LLKQLNH 136
Query: 204 PNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMK----PKVLRSWCRQILK 259
PNI+++ DS+ I + IVL EL +G L +K FK K + + + Q+
Sbjct: 137 PNIIKYLDSF--IEDNELNIVL--ELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCS 192
Query: 260 GLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLM--RTSFAKSVIGTPEFMA 317
++ +H+R ++HRD+K N+FIT TG VK+GDLGL T+ A S++GTP +M+
Sbjct: 193 AVEHMHSRR--VMHRDIKPANVFITA-TGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMS 249
Query: 318 PE-MYEEHYDESVDVYAFGMCMLEMATSEYP-YSECQNAAQIYRKVTSGIKPASFNKVTD 375
PE ++E Y+ D+++ G + EMA + P Y + N + +K+ P +
Sbjct: 250 PERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYS 309
Query: 376 PEVKEIIEGCIRQNKSERLSI 396
+++E++ CI + +R I
Sbjct: 310 EKLRELVSMCICPDPHQRPDI 330
>gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens]
Length = 313
Score = 107 bits (267), Expect = 1e-22
Identities = 86/261 (32%), Positives = 138/261 (52%), Gaps = 22/261 (8%)
Query: 149 FDIE--LGRGAFKTVYKG---LDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQH 203
F IE +GRG F VYK LD +T V + ++ + KA Q KE +LK L H
Sbjct: 45 FQIEKKIGRGQFSEVYKATCLLDRKT-VALKKVQIFEMMDAKARQDCVKEIG-LLKQLNH 102
Query: 204 PNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMK----PKVLRSWCRQILK 259
PNI+++ DS+ I + IVL EL +G L +K FK K + + + Q+
Sbjct: 103 PNIIKYLDSF--IEDNELNIVL--ELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCS 158
Query: 260 GLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLM--RTSFAKSVIGTPEFMA 317
++ +H+R ++HRD+K N+FIT TG VK+GDLGL T+ A S++GTP +M+
Sbjct: 159 AVEHMHSRR--VMHRDIKPANVFITA-TGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMS 215
Query: 318 PE-MYEEHYDESVDVYAFGMCMLEMATSEYP-YSECQNAAQIYRKVTSGIKPASFNKVTD 375
PE ++E Y+ D+++ G + EMA + P Y + N + +K+ P +
Sbjct: 216 PERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYS 275
Query: 376 PEVKEIIEGCIRQNKSERLSI 396
+++E++ CI + +R I
Sbjct: 276 EKLRELVSMCICPDPHQRPDI 296
>gi|55956904 mitogen-activated protein kinase kinase kinase 4 isoform
a [Homo sapiens]
Length = 1608
Score = 107 bits (266), Expect = 1e-22
Identities = 98/397 (24%), Positives = 179/397 (45%), Gaps = 44/397 (11%)
Query: 40 KEKNSTFSASGETV-ERKRFFRKSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVL 98
K +S G +V E R + E+ SSP +ER + A PR D S
Sbjct: 1216 KSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPAY--PRGDSSGSTRR 1273
Query: 99 RGGQEVKYEQCSKSTSEI--------SKDCFKEKNEKEMEEEAEMKAVATSPSG------ 144
Q + S++ S F+EK +EM + + V +P
Sbjct: 1274 SWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMH 1333
Query: 145 ---RFLKFDIE----LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEM 197
R + F + +G G + VY + +T +A E++ + + +E ++
Sbjct: 1334 VGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKI 1393
Query: 198 LKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQI 257
+G++HPN+VR++ + ++ + + E GTL+ + ++ V+R + +QI
Sbjct: 1394 FEGIKHPNLVRYF----GVELHREEMYIFMEYCDEGTLEEVSRLG--LQEHVIRLYSKQI 1447
Query: 258 LKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSF------AKSVIG 311
+ LH I+HRD+K NIF+T +G +K+GD G + ++ + S +G
Sbjct: 1448 TIAINVLHEHG--IVHRDIKGANIFLTS-SGLIKLGDFGCSVKLKNNAQTMPGEVNSTLG 1504
Query: 312 TPEFMAPEMYE----EHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKP 367
T +MAPE+ E + + D+++ G ++EM T + P+ E ++ QI KV G KP
Sbjct: 1505 TAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKP 1564
Query: 368 ASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAF 404
+++ PE K+ + C+ + R + LL+H+F
Sbjct: 1565 PIPERLS-PEGKDFLSHCLESDPKMRWTASQLLDHSF 1600
>gi|153945765 mitogen-activated protein kinase kinase kinase 1 [Homo
sapiens]
Length = 1512
Score = 106 bits (265), Expect = 2e-22
Identities = 75/267 (28%), Positives = 127/267 (47%), Gaps = 19/267 (7%)
Query: 152 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQR----FKEEAEMLKGLQHPNIV 207
++G GAF + Y+ D T +A ++ + T +EQ+ +EE M+ L HPNI+
Sbjct: 1248 QIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNII 1307
Query: 208 RFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTR 267
R + K L E M G++ L ++ K V+ ++ Q+L+GL +LH
Sbjct: 1308 RMLGATCE----KSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHEN 1363
Query: 268 TPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRT------SFAKSVIGTPEFMAPEMY 321
IIHRD+K N+ I ++I D G A + + F ++GT FMAPE+
Sbjct: 1364 --QIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVL 1421
Query: 322 E-EHYDESVDVYAFGMCMLEMATSEYPYS--ECQNAAQIYRKVTSGIKPASFNKVTDPEV 378
+ Y S DV++ G ++EMA ++ P++ + N + K+ S S P +
Sbjct: 1422 RGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGL 1481
Query: 379 KEIIEGCIRQNKSERLSIRDLLNHAFF 405
+++ C+ +R R+LL H F
Sbjct: 1482 RDVALRCLELQPQDRPPSRELLKHPVF 1508
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.126 0.355
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,748,646
Number of Sequences: 37866
Number of extensions: 3377504
Number of successful extensions: 14756
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 148
Number of HSP's successfully gapped in prelim test: 835
Number of HSP's that attempted gapping in prelim test: 12297
Number of HSP's gapped (non-prelim): 2234
length of query: 1800
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1683
effective length of database: 13,817,196
effective search space: 23254340868
effective search space used: 23254340868
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.