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Search of human proteins with 50658061
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family,
member 1 [Homo sapiens]
(1168 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member... 2335 0.0
gi|114688046 TBC1 domain family, member 4 [Homo sapiens] 1056 0.0
gi|164519084 RAB GTPase activating protein 1 [Homo sapiens] 216 8e-56
gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo... 182 2e-45
gi|68299759 ecotropic viral integration site 5 [Homo sapiens] 181 5e-45
gi|21687020 ecotropic viral integration site 5-like isoform 2 [H... 180 8e-45
gi|229577000 ecotropic viral integration site 5-like isoform 1 [... 178 2e-44
gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens] 122 2e-27
gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens] 122 2e-27
gi|29648315 small G protein signaling modulator 3 [Homo sapiens] 120 6e-27
gi|167614488 TBC1 domain family, member 10B [Homo sapiens] 120 1e-26
gi|13994322 TBC1 domain family, member 10A [Homo sapiens] 113 1e-24
gi|38348348 TBC1 domain family, member 10C [Homo sapiens] 112 2e-24
gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens] 109 2e-23
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens] 106 1e-22
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens] 106 1e-22
gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Ho... 105 2e-22
gi|45597177 TBC1 domain family, member 9B (with GRAM domain) iso... 97 9e-20
gi|45597175 TBC1 domain family, member 9B (with GRAM domain) iso... 97 9e-20
gi|148806902 TBC1 domain family, member 12 [Homo sapiens] 96 2e-19
gi|222352143 TBC1 domain family, member 2 [Homo sapiens] 93 2e-18
gi|156231067 TBC1 domain family, member 8 [Homo sapiens] 92 3e-18
gi|38570101 TBC1 domain family, member 8B (with GRAM domain) iso... 91 8e-18
gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens] 89 2e-17
gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens] 89 2e-17
gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens] 89 2e-17
gi|109638751 ubiquitin specific protease 6 [Homo sapiens] 76 2e-13
gi|239755853 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 75 3e-13
gi|239750365 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 75 3e-13
gi|239744669 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 75 3e-13
>gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
[Homo sapiens]
Length = 1168
Score = 2335 bits (6052), Expect = 0.0
Identities = 1168/1168 (100%), Positives = 1168/1168 (100%)
Query: 1 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV 60
MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV
Sbjct: 1 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPV 60
Query: 61 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE 120
TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE
Sbjct: 61 TKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE 120
Query: 121 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR 180
DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR
Sbjct: 121 DAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGR 180
Query: 181 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPVRRPMRKSFSQPG 240
VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPVRRPMRKSFSQPG
Sbjct: 181 VTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPVRRPMRKSFSQPG 240
Query: 241 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEV 300
LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEV
Sbjct: 241 LRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEV 300
Query: 301 YLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALV 360
YLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALV
Sbjct: 301 YLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALV 360
Query: 361 DEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTT 420
DEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTT
Sbjct: 361 DEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTT 420
Query: 421 LTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENI 480
LTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENI
Sbjct: 421 LTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENI 480
Query: 481 GSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSN 540
GSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSN
Sbjct: 481 GSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSN 540
Query: 541 TSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHF 600
TSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHF
Sbjct: 541 TSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHF 600
Query: 601 PIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERKDFESKANHLGDSGGTPVKTRRHS 660
PIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERKDFESKANHLGDSGGTPVKTRRHS
Sbjct: 601 PIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERKDFESKANHLGDSGGTPVKTRRHS 660
Query: 661 WRQQIFLRVATPQKACDSSSRYEDYSELGELPPRSPLEPVCEDGPFGPPPEEKKRTSREL 720
WRQQIFLRVATPQKACDSSSRYEDYSELGELPPRSPLEPVCEDGPFGPPPEEKKRTSREL
Sbjct: 661 WRQQIFLRVATPQKACDSSSRYEDYSELGELPPRSPLEPVCEDGPFGPPPEEKKRTSREL 720
Query: 721 RELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLST 780
RELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLST
Sbjct: 721 RELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLST 780
Query: 781 PGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQ 840
PGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQ
Sbjct: 781 PGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQ 840
Query: 841 LTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGIL 900
LTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGIL
Sbjct: 841 LTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGIL 900
Query: 901 LLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEI 960
LLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEI
Sbjct: 901 LLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEI 960
Query: 961 GPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLE 1020
GPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLE
Sbjct: 961 GPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLE 1020
Query: 1021 TIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRM 1080
TIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRM
Sbjct: 1021 TIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRM 1080
Query: 1081 DKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTLELERSALL 1140
DKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTLELERSALL
Sbjct: 1081 DKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTLELERSALL 1140
Query: 1141 QTVEELRRRSAEPSDREPECTQPEPTGD 1168
QTVEELRRRSAEPSDREPECTQPEPTGD
Sbjct: 1141 QTVEELRRRSAEPSDREPECTQPEPTGD 1168
>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
Length = 1298
Score = 1056 bits (2730), Expect = 0.0
Identities = 608/1246 (48%), Positives = 795/1246 (63%), Gaps = 132/1246 (10%)
Query: 21 FGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRK---EPVTKQVRLCVSPSGLRCEP 77
F L VG + TT+PMLPW++AE+RR S++ P ++V L +S LRC P
Sbjct: 36 FRLWYVGGSCLDHRTTLPMLPWLMAEIRRRSQKPEAGGCGAPAAREVILVLSAPFLRCVP 95
Query: 78 EPGR---------SQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKE--DAVHRQ 126
PG + Q +P ++ IFE K Q + + IHNSHD +YFA LIK D Q
Sbjct: 96 APGAGASGGTSPSATQPNPAVF--IFEHKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQ 153
Query: 127 SICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTF--SKKFEVLFCGRVTVA 184
C+VF+A D ++VP++ISSIRQ K A +E+ + +D F S+KFEVL+CG+VTV
Sbjct: 154 MACHVFRATDPSQVPDVISSIRQLSKAAMKEDAKPSKDNEDAFYNSQKFEVLYCGKVTVT 213
Query: 185 HKKAPPALIDECIEKFNHVSGSR---GSESPRPNP-------------------PHAA-- 220
HKKAP +LID+C+EKF+ R E P+P P A
Sbjct: 214 HKKAPSSLIDDCMEKFSLHEQQRLKIQGEQRGPDPGEDLADLEVVVPGSPGDCLPEEADG 273
Query: 221 -------PTGSQEPVRRPMRKSFSQPGLRSLAFRKELQDGGLRSS------GFFSSFEES 267
P G+ +P R F + L F ++ + SS ++S
Sbjct: 274 TDTHLGLPAGASQPALTSSRVCFPERILEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQKS 333
Query: 268 DIENHLISGHNIVQPTDIEENRTMLFTIGQSEVYLISPDTKKIALEKNFKEISFCSQGIR 327
S + VQP+D E+NRTMLF +G+ E+ LISPDTK + LEKNFK+IS CSQGI+
Sbjct: 334 QPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQGIK 393
Query: 328 HVDHFGFICRESSGGGGFHFVCYVFQCTNEALVDEIMMTLKQAFTVAAVQQTAKAPAQLC 387
HVDHFGFICRES G ++CYVFQC +E+LVDE+M+TLKQAF+ AA Q+AK +LC
Sbjct: 394 HVDHFGFICRESPEPGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAKTQIKLC 453
Query: 388 EGCPLQSLHKLCERIEGMNSSKTKLELQKHLTTLTNQEQATIFEEVQKLRPRNEQRENEL 447
E CP+ SLHKLCERIEG+ + KL +Q+HL++LT+ EQA IFE VQK++P ++Q ENEL
Sbjct: 454 EACPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKPVSDQEENEL 513
Query: 448 IISFLRCLYEEKQKEHIHIGEMKQTSQMAAENIGSELPPSAT---RFRLDMLKNKAKRSL 504
+I LR L E KQK H+HIGE T S +P +AT RF+LD+LKNKAKRSL
Sbjct: 514 VILHLRQLCEAKQKTHVHIGEGPSTIS------NSTIPENATSSGRFKLDILKNKAKRSL 567
Query: 505 TESLESILSRG-NKARGLQEHSISVDLDSSLSSTL------------------------- 538
T SLE+I SRG N+ RG S + +SL+S
Sbjct: 568 TSSLENIFSRGANRMRGRLGSVDSFERSNSLASEKDYSPGDSPPGTPPASPPSSAWQTFP 627
Query: 539 ------------SNTSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSP 586
++T P K L + + + G L S S E+ + LS
Sbjct: 628 EEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDG--RAQGVRSPLLRQSSS---EQCSNLSS 682
Query: 587 QQAFRRRANTLSHFPIECQEPPQPARGSPGV-------SQRKLMRYHS-VSTETPHERKD 638
+ + +N+ S P P+ +P S R +Y + + +T E D
Sbjct: 683 VRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQNSGRLSPQYENEIRQDTASESSD 742
Query: 639 FESK-------ANHLGDSGGTPVKTRRHSWRQQIFLRVATPQKACDSSSRYEDYSELGEL 691
E + +N GGT V RR SWRQ+IFLRVA+P S+ + +D + EL
Sbjct: 743 GEGRKRTSSTCSNESLSVGGTSVTPRRISWRQRIFLRVASPMNKSPSAMQQQDGLDRNEL 802
Query: 692 PPRSPLEPVCEDGPF--------GPPPEEKKRTSRELRELWQKAILQQILLLRMEKENQK 743
P SPL P E+ P P E+++ S+ELR LW+KAI QQILLLRMEKENQK
Sbjct: 803 LPLSPLSPTMEEEPLVVFLSGEDDPEKIEERKKSKELRSLWRKAIHQQILLLRMEKENQK 862
Query: 744 LQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPR 803
L+AS ++L ++++KLDYEE+ C KEV W+K L R+KI+ DME +H+ + +GVP+
Sbjct: 863 LEASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLNC-RAKIRCDMEDIHTLLKEGVPK 921
Query: 804 HHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFS 863
RGEIW+FLA Q+ L+H+ P+KQQP D+ YKELLKQLT+QQHAIL+DLGRTFPTHPYFS
Sbjct: 922 SRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFS 981
Query: 864 AQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLR 923
QLG GQLSL+N+LKAYSLLD+EVGYCQG+SFVAG+LLLHMSEE+AF+MLKFLM+D+G R
Sbjct: 982 VQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFR 1041
Query: 924 KQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFV 983
KQYRPDM+ LQIQMYQLSRLLHDYHRDLYNHLEE+EI PSLYAAPWFLT+FASQF LGFV
Sbjct: 1042 KQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFV 1101
Query: 984 ARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTIN 1043
ARVFD+IFLQGTEVIFKVALSLL S + LI++ E+ E IV+F+K+TLP++ +MEK I
Sbjct: 1102 ARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTLPDMNTSEMEKIIT 1161
Query: 1044 QVFEMDIAKQLQAYEVEYHVLQEELIDSS-PLSDNQRMDKLEKTNSSLRKQNLDLLEQLQ 1102
QVFEMDI+KQL AYEVEYHVLQ+EL +SS D++ ++KLE+ NS L++QN+DLLE+LQ
Sbjct: 1162 QVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETLEKLERANSQLKRQNMDLLEKLQ 1221
Query: 1103 VANGRIQSLEATIEKLLSSESKLKQAMLTLELERSALLQTVEELRR 1148
VA+ +IQ+LE+ +E LL+ E+K+K + TLE E+ A +TVE+LR+
Sbjct: 1222 VAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQKTVEQLRK 1267
>gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
Length = 1069
Score = 216 bits (551), Expect = 8e-56
Identities = 137/402 (34%), Positives = 213/402 (52%), Gaps = 25/402 (6%)
Query: 766 CLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPS 825
C +++ W ++LS + +++ S V GVP RGE+W+ LA + H
Sbjct: 533 CAEKILETWGELLSK-WHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEK 591
Query: 826 KQQPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQ 885
Y+ L+ + + Q AI D+ RTFP H YF G GQ SLY I KAYS+ D+
Sbjct: 592 --------YRILITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDE 643
Query: 886 EVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLH 945
E+GYCQG SF+A +LLLHM EE+AF +L +MFD GLR+ ++ + L + YQL RL+
Sbjct: 644 EIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQ 703
Query: 946 DYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSL 1005
+Y DLYNH + + +YA+ WFLT+F ++FPL V + D++ +G VIF VAL L
Sbjct: 704 EYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGL 763
Query: 1006 LGSHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDI-----AKQLQAYEVE 1060
L + K +L + E + F + LP + E+ ++ E+ K+L+ YE E
Sbjct: 764 LKTSKDDLLL-TDFEGALKFFRVQLPK--RYRSEENAKKLMELACNMKISQKKLKKYEKE 820
Query: 1061 YHVLQEELI-DSSPLSDNQRMD-KLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKL 1118
YH ++E+ P+ +R + +L++ N L ++N DL +L + S A + L
Sbjct: 821 YHTMREQQAQQEDPIERFERENRRLQEANMRLEQENDDLAHEL------VTSKIALRKDL 874
Query: 1119 LSSESKLKQAMLTLELERSALLQTVEELRRRSAEPSDREPEC 1160
++E K L + + L+ EE RR E + + C
Sbjct: 875 DNAEEKADALNKELLMTKQKLIDAEEEKRRLEEESAQLKEMC 916
>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
sapiens]
Length = 815
Score = 182 bits (462), Expect = 2e-45
Identities = 121/403 (30%), Positives = 192/403 (47%), Gaps = 51/403 (12%)
Query: 682 YEDYSELGELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQKAILQQILLLRMEKEN 741
YE S E P+ P GP P +E + E+ +
Sbjct: 455 YEVVSLQRESDKEEPVTPTSGGGPMSPQDDEAE-----------------------EESD 491
Query: 742 QKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGV 801
+L + D+ C +++ W ++L S + + + + V GV
Sbjct: 492 NELSSGTGDVSKD-----------CPEKILYSWGELLGK-WHSNLGARPKGLSTLVKSGV 539
Query: 802 PRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPY 861
P R E+W+ LA + Y+ L+ + ++Q+ I D+ RTFP H Y
Sbjct: 540 PEALRAEVWQLLAGCHDNQAMLDR--------YRILITKDSAQESVITRDIHRTFPAHDY 591
Query: 862 FSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMG 921
F G GQ SLY I KAYS+ D+++GYCQG SF+A +LLLHM EE+AF +L +M+D G
Sbjct: 592 FKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVKIMYDYG 651
Query: 922 LRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLG 981
LR YR + L + YQL RL+ + DL++H + + +YA+ WFLT+F ++FPL
Sbjct: 652 LRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFTAKFPLC 711
Query: 982 FVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIKSTLPNLGLVQMEKT 1041
V + D++ +G +IF VAL+LL + K +LQ + E + F + LP + E+
Sbjct: 712 MVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQ-ADFEGALKFFRVQLPK--RYRAEEN 768
Query: 1042 INQVFEMDI-----AKQLQAYEVEYHVLQEELIDSSPLSDNQR 1079
++ E K+L+ YE EY ++E + D +
Sbjct: 769 ARRLMEQACNIKVPTKKLKKYEKEYQTMRESQLQQEDPMDRYK 811
>gi|68299759 ecotropic viral integration site 5 [Homo sapiens]
Length = 810
Score = 181 bits (458), Expect = 5e-45
Identities = 115/389 (29%), Positives = 206/389 (52%), Gaps = 41/389 (10%)
Query: 791 EKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQHAILI 850
+++ V +G+P H R +W+ L P K Q Y ELLK + + I
Sbjct: 154 KQVKELVHKGIPHHFRAIVWQLLCSA----QSMPIKDQ-----YSELLKMTSPCEKLIRR 204
Query: 851 DLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAF 910
D+ RT+P H +F + GQ L+N++KAYSL+D+EVGYCQG +F+ G+LL+ M EEEAF
Sbjct: 205 DIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAF 264
Query: 911 KMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWF 970
+ LM D LR+ ++P M L + MYQ ++ ++ +L+ H + S+YA+ WF
Sbjct: 265 CVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSFHTSMYASSWF 324
Query: 971 LTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIKSTL 1030
LT+F + FPL R+FD+ +G E++F+V L+LL ++ ++Q + +E ++ + +
Sbjct: 325 LTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLD-MEGMLQHFQKVI 383
Query: 1031 PNLGLVQMEKTINQVFEMDI-AKQLQAYEVEYHVLQ----EELIDSSPLSD-----NQRM 1080
P+ +K I +++ +K+++ E EY ++ EE ++ L QR+
Sbjct: 384 PHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKTKEMEEQVEIKRLRTENRLLKQRI 443
Query: 1081 DKLEKTNSSLRKQNLDLLEQL--QVANGRIQSLEATI------EKLLSSE---------- 1122
+ LEK S N D + QL ++ R+ E+ +K+L E
Sbjct: 444 ETLEKHKCS-SNYNEDFVLQLEKELVQARLSEAESQCALKEMQDKVLDIEKRNNSLPDEN 502
Query: 1123 --SKLKQAMLTLELERSALLQTVEELRRR 1149
++L++ ++ ++L + + ++ELR++
Sbjct: 503 NIARLQEELIAVKLREAEAIMGLKELRQQ 531
>gi|21687020 ecotropic viral integration site 5-like isoform 2 [Homo
sapiens]
Length = 794
Score = 180 bits (456), Expect = 8e-45
Identities = 116/371 (31%), Positives = 195/371 (52%), Gaps = 35/371 (9%)
Query: 797 VGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQHAILIDLGRTF 856
+ +G+P H R +W+ L + P K Q Y ELLK + + I D+ RT+
Sbjct: 112 IRKGIPHHFRAIVWQLLCSATDM----PVKNQ-----YSELLKMSSPCEKLIRRDIARTY 162
Query: 857 PTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFL 916
P H +F Q GQ L+N++KAYSL+D+EVGYCQG +F+ G+LL+ M EEEAF + L
Sbjct: 163 PEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRL 222
Query: 917 MFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFAS 976
M + LR+ ++P M L + +YQ +L + DL H S+YA+ WFLT+F +
Sbjct: 223 MQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLT 282
Query: 977 QFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIKSTLPNLGLV 1036
FPL RVFD+ +G E++F+V L+LL ++ ++Q + +E + + + +P+
Sbjct: 283 TFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQLD-MEGMSQYFQRVIPHQFDS 341
Query: 1037 QMEKTINQVFEMDI-AKQLQAYEVEYHVLQ----EELIDSSPLSD-----NQRMDKLEK- 1085
+K + + +++ K+++ E EY ++ EE I+ L QR++ LEK
Sbjct: 342 CPDKLVLKAYQVKYNPKKMKRLEKEYAAMKSKEMEEQIEIKRLRTENRLLKQRIETLEKG 401
Query: 1086 --TNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQ------------AMLT 1131
T + ++N + +L V + S ++K S+ +L++ + L
Sbjct: 402 QVTRAQEAEENYVIKRELAVVRQQCSSAAEDLQKAQSTIRQLQEQQENPRLTEDFVSHLE 461
Query: 1132 LELERSALLQT 1142
ELE+S L +T
Sbjct: 462 TELEQSRLRET 472
>gi|229577000 ecotropic viral integration site 5-like isoform 1 [Homo
sapiens]
Length = 805
Score = 178 bits (452), Expect = 2e-44
Identities = 110/343 (32%), Positives = 185/343 (53%), Gaps = 49/343 (14%)
Query: 797 VGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQHAILIDLGRTF 856
+ +G+P H R +W+ L + P K Q Y ELLK + + I D+ RT+
Sbjct: 112 IRKGIPHHFRAIVWQLLCSATDM----PVKNQ-----YSELLKMSSPCEKLIRRDIARTY 162
Query: 857 PTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFL 916
P H +F Q GQ L+N++KAYSL+D+EVGYCQG +F+ G+LL+ M EEEAF + L
Sbjct: 163 PEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRL 222
Query: 917 MFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFAS 976
M + LR+ ++P M L + +YQ +L + DL H S+YA+ WFLT+F +
Sbjct: 223 MQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLT 282
Query: 977 QFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIKSTLPNLGLV 1036
FPL RVFD+ +G E++F+V L+LL ++ ++Q + +E + + + +P+
Sbjct: 283 TFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQLD-MEGMSQYFQRVIPH---- 337
Query: 1037 QMEKTINQVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLD 1096
Q + +++ L+AY+V+Y + ++M +LEK ++++ + ++
Sbjct: 338 QFDSCPDKLV-------LKAYQVKY--------------NPKKMKRLEKEYAAMKSKEME 376
Query: 1097 LLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTLELERSAL 1139
EQ++ I++L + LKQ + TLE E +AL
Sbjct: 377 --EQIE------------IKRLRTENRLLKQRIETLEKESAAL 405
>gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]
Length = 828
Score = 122 bits (307), Expect = 2e-27
Identities = 85/274 (31%), Positives = 138/274 (50%), Gaps = 30/274 (10%)
Query: 769 EVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQ 828
E TT W KML G K K + EK H + +G+P RGE+W L E +K ++
Sbjct: 72 ERTTKWLKMLK--GWEKYK-NTEKFHRRIYKGIPLQLRGEVWALLLEIPKMK------EE 122
Query: 829 PKDV--PYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQE 886
+D+ K + + I +D+ RTF H F + G Q SL+++L AYS+ + E
Sbjct: 123 TRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTE 182
Query: 887 VGYCQGLSFVAGILLLHMSEEEAFKMLKFL----------MFDMGLRKQYRPDMIILQIQ 936
VGYCQG+S + +LL++M+EE+AF L L F G K +L+ Q
Sbjct: 183 VGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPK-------LLRFQ 235
Query: 937 MYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTE 996
+ ++L+ + L HL+ EI S Y WF F + P R++D+ +G
Sbjct: 236 EHH-EKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGER 294
Query: 997 VIFKVALSLLGSHKPLILQHENLETIVDFIKSTL 1030
V+ ++ ++L HK +++ ++E +V+F + TL
Sbjct: 295 VLTAMSYTILKLHKKHLMK-LSMEELVEFFQETL 327
>gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]
Length = 845
Score = 122 bits (307), Expect = 2e-27
Identities = 85/274 (31%), Positives = 138/274 (50%), Gaps = 30/274 (10%)
Query: 769 EVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQ 828
E TT W KML G K K + EK H + +G+P RGE+W L E +K ++
Sbjct: 89 ERTTKWLKMLK--GWEKYK-NTEKFHRRIYKGIPLQLRGEVWALLLEIPKMK------EE 139
Query: 829 PKDV--PYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQE 886
+D+ K + + I +D+ RTF H F + G Q SL+++L AYS+ + E
Sbjct: 140 TRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTE 199
Query: 887 VGYCQGLSFVAGILLLHMSEEEAFKMLKFL----------MFDMGLRKQYRPDMIILQIQ 936
VGYCQG+S + +LL++M+EE+AF L L F G K +L+ Q
Sbjct: 200 VGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPK-------LLRFQ 252
Query: 937 MYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTE 996
+ ++L+ + L HL+ EI S Y WF F + P R++D+ +G
Sbjct: 253 EHH-EKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGER 311
Query: 997 VIFKVALSLLGSHKPLILQHENLETIVDFIKSTL 1030
V+ ++ ++L HK +++ ++E +V+F + TL
Sbjct: 312 VLTAMSYTILKLHKKHLMK-LSMEELVEFFQETL 344
>gi|29648315 small G protein signaling modulator 3 [Homo sapiens]
Length = 749
Score = 120 bits (302), Expect = 6e-27
Identities = 107/397 (26%), Positives = 186/397 (46%), Gaps = 44/397 (11%)
Query: 774 WEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVP 833
W+K+ + RS EK+ S V G+P R ++W L+ K++ ++
Sbjct: 94 WDKIAVSLPRS------EKLRSLVLAGIPHGMRPQLWMRLSGALQ-------KKRNSELS 140
Query: 834 YKELLKQLTSQQ----HAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGY 889
Y+E++K ++ + I DL RT P++ F++ G L +L+A + L E+GY
Sbjct: 141 YREIVKNSSNDETIAAKQIEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGY 200
Query: 890 CQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHR 949
CQG VA LLL + EE+AF M+ ++ D+ + ++ +Q L L+ Y
Sbjct: 201 CQGTGMVAACLLLFLEEEDAFWMMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLP 260
Query: 950 DLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSH 1009
L L+EH+I SL WFLT FAS + + R++D+ F +G+ V+F++ L +L
Sbjct: 261 RLDKLLQEHDIELSLITLHWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLK 320
Query: 1010 KPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQL--QAYEVEYHVLQEE 1067
+ ++Q EN +I + + S +P+ QME + + +A +L +V + +
Sbjct: 321 EEELIQSENSASIFNTL-SDIPS----QME---DAELLLGVAMRLAGSLTDVAVETQRRK 372
Query: 1068 LIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQ 1127
+ Q + TN S QV R Q ++TI LL E L +
Sbjct: 373 HLAYLIADQGQLLGAGTLTNLS------------QVVRRRTQRRKSTITALLFGEDDL-E 419
Query: 1128 AMLTLELERSALLQTVEELRRRSAEPSDREPECTQPE 1164
A+ ++++ L+ + E R A R +CT P+
Sbjct: 420 ALKAKNIKQTELVADLREAILRVA----RHFQCTDPK 452
>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
Length = 808
Score = 120 bits (300), Expect = 1e-26
Identities = 81/238 (34%), Positives = 117/238 (49%), Gaps = 24/238 (10%)
Query: 774 WEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSK-----QQ 828
W+K LS + K+K K G+P R + W++L+ L Q P K +
Sbjct: 342 WDKWLSRRFQ-KVKLRCRK-------GIPSSLRAKAWQYLSNSKELLEQNPGKFEELERA 393
Query: 829 PKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVG 888
P D + +++++ DL R FP H F+A+ G GQ LY ILKAY++ + G
Sbjct: 394 PGDPKWLDVIEK----------DLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEG 443
Query: 889 YCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYH 948
YCQ + VA +LL+HM E+AF L + D L Y + +Q+ LL
Sbjct: 444 YCQAQAPVAAVLLMHMPAEQAFWCL-VQICDKYLPGYYSAGLEAIQLDGEIFFALLRRAS 502
Query: 949 RDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLL 1006
+ HL I P LY WF+ +FA P V RV+DM F +G ++IF+VAL LL
Sbjct: 503 PLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLL 560
>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
Length = 508
Score = 113 bits (282), Expect = 1e-24
Identities = 86/296 (29%), Positives = 141/296 (47%), Gaps = 24/296 (8%)
Query: 767 LKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSK 826
L++ + W ML+ + K +K+ +G+P RG W++L+ Q P K
Sbjct: 79 LRQRESKWLDMLNNWDKWMAK-KHKKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGK 137
Query: 827 -----QQPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYS 881
P D + +++++ DL R FP H F ++ G GQ L+ +LKAY+
Sbjct: 138 FDELDMSPGDPKWLDVIER----------DLHRQFPFHEMFVSRGGHGQQDLFRVLKAYT 187
Query: 882 LLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLS 941
L E GYCQ + +A +LL+HM E+AF L + + L Y + +Q+ L
Sbjct: 188 LYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCL-VQICEKYLPGYYSEKLEAIQLDGEILF 246
Query: 942 RLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKV 1001
LL + HL +I P LY WF+ F+ P V RV+DM F +G ++IF+V
Sbjct: 247 SLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGVKIIFRV 306
Query: 1002 ALSL----LGSHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQ 1053
L L LGS + + ETI + ++S P ++Q + +V E+ + ++
Sbjct: 307 GLVLLKHALGSPEKVKACQGQYETI-ERLRSLSPK--IMQEAFLVQEVVELPVTER 359
>gi|38348348 TBC1 domain family, member 10C [Homo sapiens]
Length = 446
Score = 112 bits (281), Expect = 2e-24
Identities = 78/243 (32%), Positives = 112/243 (46%), Gaps = 24/243 (9%)
Query: 769 EVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQ 828
E+T+ WEK +S + K+K K G+P R W L + P Q
Sbjct: 69 EMTSHWEKTMSRRYK-KVKMQCRK-------GIPSALRARCWPLLCGAHVCQKNSPGTYQ 120
Query: 829 -----PKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLL 883
P D + E + + DL R FP H F + G GQ L +LKAY+L
Sbjct: 121 ELAEAPGDPQWMETIGR----------DLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLY 170
Query: 884 DQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRL 943
E GYCQ VA +LL+H+ EEAF L + ++ L Y P M +++ L
Sbjct: 171 RPEQGYCQAQGPVAAVLLMHLPPEEAFWCL-VQICEVYLPGYYGPHMEAVRLDAEVFMAL 229
Query: 944 LHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVAL 1003
L ++ HL++ +GP LY WFL +FA P V RV+D +G V+F+V L
Sbjct: 230 LRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGL 289
Query: 1004 SLL 1006
+L+
Sbjct: 290 TLV 292
>gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens]
Length = 336
Score = 109 bits (272), Expect = 2e-23
Identities = 78/254 (30%), Positives = 131/254 (51%), Gaps = 12/254 (4%)
Query: 797 VGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQ--QHAILIDLGR 854
V +GVP HR +W L+ Q P Y +LL+ + + AI DL R
Sbjct: 65 VRKGVPLEHRARVWMVLSGAQAQMDQNPGY-------YHQLLQGERNPRLEDAIRTDLNR 117
Query: 855 TFPTHPYFSAQLGAG-QLSLYNILKAYSLLDQEVGYCQGLSFVAG-ILLLHMSEEEAFKM 912
TFP + F Q +LYN+L AY +Q VGYCQG++F+AG ++L+ +EEE+F +
Sbjct: 118 TFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWL 177
Query: 913 LKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLT 972
L L+ + L Y P M+ L+ L L+ + +E + +L + WF+
Sbjct: 178 LDALVGRI-LPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFIC 236
Query: 973 MFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIKSTLPN 1032
+F P+ V R++D +F +G+++IF+VAL+L+ H+ LIL+ ++ I D K
Sbjct: 237 LFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKG 296
Query: 1033 LGLVQMEKTINQVF 1046
+++ + ++F
Sbjct: 297 SFVMECHTFMQKIF 310
>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
Length = 963
Score = 106 bits (265), Expect = 1e-22
Identities = 72/295 (24%), Positives = 145/295 (49%), Gaps = 15/295 (5%)
Query: 738 EKENQKLQASENDLLNKRLKL-DYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSA 796
+ E +KL A L K L L + +E++ +K WE ++ ++ E + +
Sbjct: 605 DDEEEKLVAKVRALDLKTLYLTENQEVSTGVK-----WENYFASTVNREMMCSPE-LKNL 658
Query: 797 VGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQH----AILIDL 852
+ G+P HR ++WK+ + +H K + ++ LL++ +Q+ I +DL
Sbjct: 659 IRAGIPHEHRSKVWKWCVD----RHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELDL 714
Query: 853 GRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKM 912
RT P + ++S G L N+L A+S + ++GYCQGL+ + + LL++ +E+AF
Sbjct: 715 LRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFWC 774
Query: 913 LKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLT 972
L ++ R Y ++ Q+ L+ + L+ H E++++ +L WFL
Sbjct: 775 LVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLV 834
Query: 973 MFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIK 1027
+F + +++D +G +VIF+ AL+L + IL+ ++ +I +++
Sbjct: 835 VFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLR 889
Score = 30.8 bits (68), Expect = 7.9
Identities = 38/148 (25%), Positives = 65/148 (43%), Gaps = 25/148 (16%)
Query: 373 VAAVQQTAKAP--------AQLCEGCP---LQSLHKLCERIEGMNSSKTKLELQKHLTTL 421
V +QQT ++ ++LCEG P L+ LH+ ++I G+ S + L+K
Sbjct: 365 VRLLQQTVRSSQYDKYFTSSRLCEGVPKDTLELLHQKDDQILGLTSQLERFSLEKE---S 421
Query: 422 TNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHI--GEMKQTSQMAAEN 479
QE T+ +V +L NEQ + L + K + I + GE A +
Sbjct: 422 LQQEVRTLKSKVGEL---NEQ------LGMLMETIQAKDEVIIKLSEGEGNGPPPTVAPS 472
Query: 480 IGSELPPSATRFRLDMLKNKAKRSLTES 507
S +P + + LD LK+ + T++
Sbjct: 473 SPSVVPVARDQLELDRLKDNLQGYKTQN 500
>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
Length = 914
Score = 106 bits (265), Expect = 1e-22
Identities = 72/295 (24%), Positives = 145/295 (49%), Gaps = 15/295 (5%)
Query: 738 EKENQKLQASENDLLNKRLKL-DYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSA 796
+ E +KL A L K L L + +E++ +K WE ++ ++ E + +
Sbjct: 605 DDEEEKLVAKVRALDLKTLYLTENQEVSTGVK-----WENYFASTVNREMMCSPE-LKNL 658
Query: 797 VGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQH----AILIDL 852
+ G+P HR ++WK+ + +H K + ++ LL++ +Q+ I +DL
Sbjct: 659 IRAGIPHEHRSKVWKWCVD----RHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELDL 714
Query: 853 GRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKM 912
RT P + ++S G L N+L A+S + ++GYCQGL+ + + LL++ +E+AF
Sbjct: 715 LRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFWC 774
Query: 913 LKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLT 972
L ++ R Y ++ Q+ L+ + L+ H E++++ +L WFL
Sbjct: 775 LVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLV 834
Query: 973 MFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIK 1027
+F + +++D +G +VIF+ AL+L + IL+ ++ +I +++
Sbjct: 835 VFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLR 889
Score = 30.8 bits (68), Expect = 7.9
Identities = 38/148 (25%), Positives = 65/148 (43%), Gaps = 25/148 (16%)
Query: 373 VAAVQQTAKAP--------AQLCEGCP---LQSLHKLCERIEGMNSSKTKLELQKHLTTL 421
V +QQT ++ ++LCEG P L+ LH+ ++I G+ S + L+K
Sbjct: 365 VRLLQQTVRSSQYDKYFTSSRLCEGVPKDTLELLHQKDDQILGLTSQLERFSLEKE---S 421
Query: 422 TNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHI--GEMKQTSQMAAEN 479
QE T+ +V +L NEQ + L + K + I + GE A +
Sbjct: 422 LQQEVRTLKSKVGEL---NEQ------LGMLMETIQAKDEVIIKLSEGEGNGPPPTVAPS 472
Query: 480 IGSELPPSATRFRLDMLKNKAKRSLTES 507
S +P + + LD LK+ + T++
Sbjct: 473 SPSVVPVARDQLELDRLKDNLQGYKTQN 500
>gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Homo
sapiens]
Length = 1266
Score = 105 bits (263), Expect = 2e-22
Identities = 89/334 (26%), Positives = 159/334 (47%), Gaps = 22/334 (6%)
Query: 774 WEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVP 833
W+ + G+ + EK V +G+P RGE+W L+ + K P + D+
Sbjct: 489 WKIHFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEKATHPGYYE--DLV 546
Query: 834 YKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGL 893
K + K + + I DL R+ P HP F ++G +L +L AY+ + +GYCQ +
Sbjct: 547 EKSMGKYNLATEE-IERDLHRSLPEHPAFQNEMGIA--ALRRVLTAYAFRNPNIGYCQAM 603
Query: 894 SFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYN 953
+ V +LLL+ EEEAF +L L M L Y ++ + L DY LY+
Sbjct: 604 NIVTSVLLLYAKEEEAFWLLVALCERM-LPDYYNTRVVGALVDQGVFEELARDYVPQLYD 662
Query: 954 HLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLI 1013
+++ + S + WFLT+F S P V D F +G +VIF++AL++L ++ +
Sbjct: 663 CMQDLGV-ISTISLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKL 721
Query: 1014 LQHEN-------LETIVDFI---KSTLPNLGLVQ--MEKTINQVFEMDIAKQLQAYEVEY 1061
L ++ L +D + STLP + + + + E+DI + ++ ++
Sbjct: 722 LNCKDDGEAMTVLGRYLDSVTNKDSTLPPIPHLHSLLSDDVEPYPEVDIFRLIRTSYEKF 781
Query: 1062 HVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNL 1095
++ +LI+ + QR+ K+ +T K+N+
Sbjct: 782 GTIRADLIEQ--MRFKQRL-KVIQTLEDTTKRNV 812
>gi|45597177 TBC1 domain family, member 9B (with GRAM domain) isoform
b [Homo sapiens]
Length = 1233
Score = 97.1 bits (240), Expect = 9e-20
Identities = 88/342 (25%), Positives = 143/342 (41%), Gaps = 44/342 (12%)
Query: 677 DSSSRYEDYSELGELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQKAILQQILLLR 736
D S+ + G P SP P+ F +E S+ L +L+QK + L +
Sbjct: 414 DPSTESSPAPQEGSEQPASPASPLSSRQSFCA--QEAPTASQGLLKLFQKNSPMEDLGAK 471
Query: 737 MEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSA 796
KE K ++ W GR + K +
Sbjct: 472 GAKEKMKEES---------------------------WHIHFFEYGRGVCMYRTAKTRAL 504
Query: 797 VGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQ----HAILIDL 852
V +G+P RGE+W + ++ P Y EL+++ T + I DL
Sbjct: 505 VLKGIPESLRGELWLLFSGAWNEMVTHPGY-------YAELVEKSTGKYSLATEEIERDL 557
Query: 853 GRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKM 912
R+ P HP F +LG +L +L AY+ + +GYCQ ++ V +LLL+ SEEEAF +
Sbjct: 558 HRSMPEHPAFQNELGIA--ALRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFWL 615
Query: 913 LKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLT 972
L L M L Y ++ + L D+ L +++ + S+ + WFLT
Sbjct: 616 LVALCERM-LPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVISSI-SLSWFLT 673
Query: 973 MFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLIL 1014
+F S P + D F +G +VI +VAL++L ++ +L
Sbjct: 674 LFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLL 715
>gi|45597175 TBC1 domain family, member 9B (with GRAM domain) isoform
a [Homo sapiens]
Length = 1250
Score = 97.1 bits (240), Expect = 9e-20
Identities = 88/342 (25%), Positives = 143/342 (41%), Gaps = 44/342 (12%)
Query: 677 DSSSRYEDYSELGELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQKAILQQILLLR 736
D S+ + G P SP P+ F +E S+ L +L+QK + L +
Sbjct: 414 DPSTESSPAPQEGSEQPASPASPLSSRQSFCA--QEAPTASQGLLKLFQKNSPMEDLGAK 471
Query: 737 MEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSA 796
KE K ++ W GR + K +
Sbjct: 472 GAKEKMKEES---------------------------WHIHFFEYGRGVCMYRTAKTRAL 504
Query: 797 VGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQ----HAILIDL 852
V +G+P RGE+W + ++ P Y EL+++ T + I DL
Sbjct: 505 VLKGIPESLRGELWLLFSGAWNEMVTHPGY-------YAELVEKSTGKYSLATEEIERDL 557
Query: 853 GRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKM 912
R+ P HP F +LG +L +L AY+ + +GYCQ ++ V +LLL+ SEEEAF +
Sbjct: 558 HRSMPEHPAFQNELGIA--ALRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFWL 615
Query: 913 LKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLT 972
L L M L Y ++ + L D+ L +++ + S+ + WFLT
Sbjct: 616 LVALCERM-LPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVISSI-SLSWFLT 673
Query: 973 MFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLIL 1014
+F S P + D F +G +VI +VAL++L ++ +L
Sbjct: 674 LFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLL 715
>gi|148806902 TBC1 domain family, member 12 [Homo sapiens]
Length = 775
Score = 95.9 bits (237), Expect = 2e-19
Identities = 88/373 (23%), Positives = 151/373 (40%), Gaps = 42/373 (11%)
Query: 662 RQQIFLRVATPQKACDSSSRYEDYSELGELPPRSPLEPVCEDGPFGPPP---EEKKRTSR 718
+Q+ R K SSR +++ E P S + ED P P EE R +
Sbjct: 364 QQEYEARTGRTCKPPPQSSRRKNF----EFEPLSTTALILEDRPSNLPAKSVEEALRHRQ 419
Query: 719 ELRELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKML 778
E E+ +A ++I K K + + + + + + EI P WE M
Sbjct: 420 EYDEMVAEAKKREIKEAHKRKRIMKERFKQEENIASAMVIWINEILPN-------WEVMR 472
Query: 779 STPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWK----------------FLAEQFHLKHQ 822
ST ++ QG+P RG++W FL+
Sbjct: 473 ST----------RRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKS 522
Query: 823 FPSKQQPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSL 882
F D + + S + I +D+ RTFP+ Y + G L++IL AY+
Sbjct: 523 FSETSSENDTEGVSVADREASLE-LIKLDISRTFPSL-YIFQKGGPYHDVLHSILGAYTC 580
Query: 883 LDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSR 942
+VGY QG+SF+A +L+L++ E +AF L+ +R D ++
Sbjct: 581 YRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEV 640
Query: 943 LLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVA 1002
+ L+ H + + + P +Y W T+++ PL RV+D+ G E +F+
Sbjct: 641 FFEENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTG 700
Query: 1003 LSLLGSHKPLILQ 1015
L +L ++ ++LQ
Sbjct: 701 LGILRLYEDILLQ 713
>gi|222352143 TBC1 domain family, member 2 [Homo sapiens]
Length = 917
Score = 92.8 bits (229), Expect = 2e-18
Identities = 68/211 (32%), Positives = 102/211 (48%), Gaps = 12/211 (5%)
Query: 800 GVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQHA----ILIDLGRT 855
GVPR HR +W++L HL+ Q Y+ELL + +++H I +DL RT
Sbjct: 625 GVPREHRPRVWRWLV---HLRVQHLHTPGC----YQELLSRGQAREHPAARQIELDLNRT 677
Query: 856 FPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEE-AFKMLK 914
FP + +F+ + L +L A+S + +GYCQGL+ +A I LL + EEE AF L
Sbjct: 678 FPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLV 737
Query: 915 FLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMF 974
++ + Y + Q+ L LL + L HL +H + SL WFL +F
Sbjct: 738 AIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVF 797
Query: 975 ASQFPLGFVARVFDMIFLQGTEVIFKVALSL 1005
A + RV+D +GT+ K L L
Sbjct: 798 ADSLISNILLRVWDAFLYEGTKYNEKEILRL 828
>gi|156231067 TBC1 domain family, member 8 [Homo sapiens]
Length = 1140
Score = 92.0 bits (227), Expect = 3e-18
Identities = 65/235 (27%), Positives = 106/235 (45%), Gaps = 7/235 (2%)
Query: 772 TVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKD 831
++W GR+ F EK+ V G+P RG +W ++ P
Sbjct: 477 SLWNDHFVEYGRTVCMFRTEKIRKLVAMGIPESLRGRLWLLFSDAVTDLASHPGYYGNL- 535
Query: 832 VPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQ 891
+E L + I DL R+ P HP F + G +L +L AY+ + ++GYCQ
Sbjct: 536 --VEESLGKCCLVTEEIERDLHRSLPEHPAFQNETGIA--ALRRVLTAYAHRNPKIGYCQ 591
Query: 892 GLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDL 951
++ + +LLL+ EEEAF +L + M L + +I Q+ L+ + +L
Sbjct: 592 SMNILTSVLLLYTKEEEAFWLLVAVCERM-LPDYFNHRVIGAQVDQSVFEELIKGHLPEL 650
Query: 952 YNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLL 1006
H+ + S+ + WFLT+F S PL V D F G + IF++ L++L
Sbjct: 651 AEHMNDLSALASV-SLSWFLTLFLSIMPLESAVNVVDCFFYDGIKAIFQLGLAVL 704
>gi|38570101 TBC1 domain family, member 8B (with GRAM domain) isoform
a [Homo sapiens]
Length = 1120
Score = 90.5 bits (223), Expect = 8e-18
Identities = 64/237 (27%), Positives = 107/237 (45%), Gaps = 15/237 (6%)
Query: 774 WEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVP 833
W+ + + GR F +K V +G+P RGE+W + + P
Sbjct: 461 WKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDY------- 513
Query: 834 YKELLKQLTSQ----QHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGY 889
Y E+++Q I DL R+ P HP F + G +L +L AY+ + ++GY
Sbjct: 514 YTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGIS--ALRRVLTAYAYRNPKIGY 571
Query: 890 CQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHR 949
CQ ++ + +LLL+ EEEAF +L + M L + +I + L+ D+
Sbjct: 572 CQAMNILTSVLLLYAKEEEAFWLLVAVCERM-LPDYFNRRIIGALVDQAVFEELIRDHLP 630
Query: 950 DLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLL 1006
L H+ + S+ + WFLT+F S P+ V D F G + I ++ L++L
Sbjct: 631 QLTEHMTDMTFFSSV-SLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAIL 686
>gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens]
Length = 413
Score = 89.4 bits (220), Expect = 2e-17
Identities = 76/356 (21%), Positives = 148/356 (41%), Gaps = 43/356 (12%)
Query: 690 ELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQASEN 749
+ P S + ED P P + + + R+ +++ ++Q E + +K Q E
Sbjct: 25 DFEPLSTTALILEDRPANLPAKPAEEAQKH-RQQYEEMVVQAKKRELKEAQRRKKQLEER 83
Query: 750 DLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEI 809
+ + + + E+ WE M + K+ QG+P RG++
Sbjct: 84 CRVEESIG---NAVLTWNNEILPNWETMWCS----------RKVRDLWWQGIPPSVRGKV 130
Query: 810 WKF-LAEQFHLKHQF------------------PSKQQPKDVPYKELLKQLTSQQHAILI 850
W + + ++ H+ S+ + +D + ++ + + I +
Sbjct: 131 WSLAIGNELNITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLE--LIKL 188
Query: 851 DLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAF 910
D+ RTFP F Q G L++IL AY+ +VGY QG+SF+A +L+L++ +AF
Sbjct: 189 DISRTFPNLCIFQ-QGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAF 247
Query: 911 KMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWF 970
L+ +R D ++ + L+ H +++ + P +Y W
Sbjct: 248 IAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWI 307
Query: 971 LTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFI 1026
T+++ PL R++D+ G E +F+ AL +L E++ T +DFI
Sbjct: 308 FTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGIL-------KLFEDILTKMDFI 356
>gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens]
Length = 693
Score = 89.4 bits (220), Expect = 2e-17
Identities = 76/356 (21%), Positives = 148/356 (41%), Gaps = 43/356 (12%)
Query: 690 ELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQASEN 749
+ P S + ED P P + + + R+ +++ ++Q E + +K Q E
Sbjct: 305 DFEPLSTTALILEDRPANLPAKPAEEAQKH-RQQYEEMVVQAKKRELKEAQRRKKQLEER 363
Query: 750 DLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEI 809
+ + + + E+ WE M + K+ QG+P RG++
Sbjct: 364 CRVEESIG---NAVLTWNNEILPNWETMWCS----------RKVRDLWWQGIPPSVRGKV 410
Query: 810 WKF-LAEQFHLKHQF------------------PSKQQPKDVPYKELLKQLTSQQHAILI 850
W + + ++ H+ S+ + +D + ++ + + I +
Sbjct: 411 WSLAIGNELNITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLE--LIKL 468
Query: 851 DLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAF 910
D+ RTFP F Q G L++IL AY+ +VGY QG+SF+A +L+L++ +AF
Sbjct: 469 DISRTFPNLCIFQ-QGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAF 527
Query: 911 KMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWF 970
L+ +R D ++ + L+ H +++ + P +Y W
Sbjct: 528 IAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWI 587
Query: 971 LTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFI 1026
T+++ PL R++D+ G E +F+ AL +L E++ T +DFI
Sbjct: 588 FTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGIL-------KLFEDILTKMDFI 636
>gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens]
Length = 693
Score = 89.4 bits (220), Expect = 2e-17
Identities = 76/356 (21%), Positives = 148/356 (41%), Gaps = 43/356 (12%)
Query: 690 ELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQASEN 749
+ P S + ED P P + + + R+ +++ ++Q E + +K Q E
Sbjct: 305 DFEPLSTTALILEDRPANLPAKPAEEAQKH-RQQYEEMVVQAKKRELKEAQRRKKQLEER 363
Query: 750 DLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEI 809
+ + + + E+ WE M + K+ QG+P RG++
Sbjct: 364 CRVEESIG---NAVLTWNNEILPNWETMWCS----------RKVRDLWWQGIPPSVRGKV 410
Query: 810 WKF-LAEQFHLKHQF------------------PSKQQPKDVPYKELLKQLTSQQHAILI 850
W + + ++ H+ S+ + +D + ++ + + I +
Sbjct: 411 WSLAIGNELNITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLE--LIKL 468
Query: 851 DLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAF 910
D+ RTFP F Q G L++IL AY+ +VGY QG+SF+A +L+L++ +AF
Sbjct: 469 DISRTFPNLCIFQ-QGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAF 527
Query: 911 KMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWF 970
L+ +R D ++ + L+ H +++ + P +Y W
Sbjct: 528 IAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWI 587
Query: 971 LTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFI 1026
T+++ PL R++D+ G E +F+ AL +L E++ T +DFI
Sbjct: 588 FTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGIL-------KLFEDILTKMDFI 636
>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
Length = 1406
Score = 75.9 bits (185), Expect = 2e-13
Identities = 61/233 (26%), Positives = 104/233 (44%), Gaps = 9/233 (3%)
Query: 771 TTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPK 830
T+ W +ML G + K+ V +G+P + RG +W L +K + P + Q
Sbjct: 74 TSKWMEML---GEWETYKHSSKLIDRVYKGIPMNIRGPVWSVLLNIQEIKLKNPGRYQIM 130
Query: 831 DVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYC 890
KE K+ + H I +D+ T H +F + GA Q L+ IL AYS + EVGYC
Sbjct: 131 ----KERGKRSSEHIHHIDLDVRTTLRNHVFFRDRYGAKQRELFYILLAYSEYNPEVGYC 186
Query: 891 QGLSFVAGILLLHMSEEEAFKMLKFLMFD--MGLRKQYRPDMIILQIQMYQLSRLLHDYH 948
+ LS + + LL++ EE+AF L L+ L + P+ +Q Q ++
Sbjct: 187 RDLSHITALFLLYLPEEDAFWALVQLLASERHSLPGFHSPNGGTVQGLQDQQEHVVPKSQ 246
Query: 949 RDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKV 1001
H ++ + + L LG R++D+ ++G +V+ +
Sbjct: 247 PKTMWHQDKEGLCGQCASLGCLLRNLIDGISLGLTLRLWDVYLVEGEQVLMPI 299
>gi|239755853 PREDICTED: TBC1 domain family, member 30 [Homo sapiens]
Length = 761
Score = 75.5 bits (184), Expect = 3e-13
Identities = 71/286 (24%), Positives = 129/286 (45%), Gaps = 40/286 (13%)
Query: 788 FDMEKMHSAVGQGVPRHHRGEIWKFLAEQF----------HLKHQFPSKQQPKDVPYKEL 837
+D K + + G+P+ R ++W LA+ + ++ F + P D
Sbjct: 74 YDALKAVARLSTGIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFNERSNPDD------ 127
Query: 838 LKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVA 897
S I+ DL RT Y + ++ L +L AY+ ++ VGYCQG + +A
Sbjct: 128 ----DSMGIQIVKDLHRT-GCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILA 182
Query: 898 GILLLHM--SEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHL 955
++L M +E +A K++ +L+ + + ++ L + M LL +L HL
Sbjct: 183 ALILEVMEGNEGDALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHL 242
Query: 956 E------EHEIG-------PSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVA 1002
+ E G +++ WFLT+FA+ P V +++D +F +G+E+I +V+
Sbjct: 243 DTLQRTANKESGGGYEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVS 302
Query: 1003 LSLLGSHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEM 1048
L++ L Q E ET +F ST+ L +E + Q E+
Sbjct: 303 LAIWAK---LGEQIECCETADEFY-STMGRLTQEMLENDLLQSHEL 344
>gi|239750365 PREDICTED: TBC1 domain family, member 30 [Homo sapiens]
Length = 761
Score = 75.5 bits (184), Expect = 3e-13
Identities = 71/286 (24%), Positives = 129/286 (45%), Gaps = 40/286 (13%)
Query: 788 FDMEKMHSAVGQGVPRHHRGEIWKFLAEQF----------HLKHQFPSKQQPKDVPYKEL 837
+D K + + G+P+ R ++W LA+ + ++ F + P D
Sbjct: 74 YDALKAVARLSTGIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFNERSNPDD------ 127
Query: 838 LKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVA 897
S I+ DL RT Y + ++ L +L AY+ ++ VGYCQG + +A
Sbjct: 128 ----DSMGIQIVKDLHRT-GCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILA 182
Query: 898 GILLLHM--SEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHL 955
++L M +E +A K++ +L+ + + ++ L + M LL +L HL
Sbjct: 183 ALILEVMEGNEGDALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHL 242
Query: 956 E------EHEIG-------PSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVA 1002
+ E G +++ WFLT+FA+ P V +++D +F +G+E+I +V+
Sbjct: 243 DTLQRTANKESGGGYEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVS 302
Query: 1003 LSLLGSHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEM 1048
L++ L Q E ET +F ST+ L +E + Q E+
Sbjct: 303 LAIWAK---LGEQIECCETADEFY-STMGRLTQEMLENDLLQSHEL 344
>gi|239744669 PREDICTED: TBC1 domain family, member 30 [Homo sapiens]
Length = 761
Score = 75.5 bits (184), Expect = 3e-13
Identities = 71/286 (24%), Positives = 129/286 (45%), Gaps = 40/286 (13%)
Query: 788 FDMEKMHSAVGQGVPRHHRGEIWKFLAEQF----------HLKHQFPSKQQPKDVPYKEL 837
+D K + + G+P+ R ++W LA+ + ++ F + P D
Sbjct: 74 YDALKAVARLSTGIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFNERSNPDD------ 127
Query: 838 LKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVA 897
S I+ DL RT Y + ++ L +L AY+ ++ VGYCQG + +A
Sbjct: 128 ----DSMGIQIVKDLHRT-GCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILA 182
Query: 898 GILLLHM--SEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHL 955
++L M +E +A K++ +L+ + + ++ L + M LL +L HL
Sbjct: 183 ALILEVMEGNEGDALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHL 242
Query: 956 E------EHEIG-------PSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVA 1002
+ E G +++ WFLT+FA+ P V +++D +F +G+E+I +V+
Sbjct: 243 DTLQRTANKESGGGYEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVS 302
Query: 1003 LSLLGSHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEM 1048
L++ L Q E ET +F ST+ L +E + Q E+
Sbjct: 303 LAIWAK---LGEQIECCETADEFY-STMGRLTQEMLENDLLQSHEL 344
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,918,335
Number of Sequences: 37866
Number of extensions: 2308684
Number of successful extensions: 11596
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 97
Number of HSP's successfully gapped in prelim test: 257
Number of HSP's that attempted gapping in prelim test: 10639
Number of HSP's gapped (non-prelim): 1229
length of query: 1168
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1055
effective length of database: 13,968,660
effective search space: 14736936300
effective search space used: 14736936300
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.