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Search of human proteins with 4885065
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4885065 amyloid precursor-like protein 1 isoform 2 precursor
[Homo sapiens]
(650 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4885065 amyloid precursor-like protein 1 isoform 2 precursor ... 1320 0.0
gi|67782338 amyloid precursor-like protein 1 isoform 1 precursor... 1316 0.0
gi|214010183 amyloid beta (A4) precursor-like protein 2 isoform ... 473 e-133
gi|41406057 amyloid beta A4 protein isoform c precursor [Homo sa... 442 e-124
gi|209915570 amyloid beta A4 protein isoform e precursor [Homo s... 392 e-109
gi|41406055 amyloid beta A4 protein isoform b precursor [Homo sa... 356 4e-98
gi|214010185 amyloid beta (A4) precursor-like protein 2 isoform ... 302 6e-82
gi|4502147 amyloid beta (A4) precursor-like protein 2 isoform 1 ... 302 6e-82
gi|214010181 amyloid beta (A4) precursor-like protein 2 isoform ... 302 7e-82
gi|4502167 amyloid beta A4 protein isoform a precursor [Homo sap... 254 2e-67
gi|209915573 amyloid beta A4 protein isoform f precursor [Homo s... 254 2e-67
gi|91208420 bassoon protein [Homo sapiens] 45 3e-04
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 42 0.001
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 42 0.001
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 42 0.001
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 42 0.001
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 42 0.001
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 42 0.001
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 42 0.001
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 42 0.001
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 42 0.002
gi|138175817 zinc finger protein 236 [Homo sapiens] 41 0.003
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 41 0.004
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 41 0.004
gi|209862789 microtubule associated monoxygenase, calponin and L... 40 0.005
gi|32484977 angiomotin like 2 [Homo sapiens] 40 0.005
gi|33356148 formin-like 1 [Homo sapiens] 40 0.007
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 40 0.009
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 39 0.011
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 39 0.011
>gi|4885065 amyloid precursor-like protein 1 isoform 2 precursor
[Homo sapiens]
Length = 650
Score = 1320 bits (3417), Expect = 0.0
Identities = 650/650 (100%), Positives = 650/650 (100%)
Query: 1 MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLC 60
MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLC
Sbjct: 1 MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLC 60
Query: 61 GRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWC 120
GRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWC
Sbjct: 61 GRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWC 120
Query: 121 GGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA 180
GGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA
Sbjct: 121 GGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA 180
Query: 181 CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGA 240
CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGA
Sbjct: 181 CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGA 240
Query: 241 EDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGM 300
EDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGM
Sbjct: 241 EDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGM 300
Query: 301 PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT 360
PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT
Sbjct: 301 PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT 360
Query: 361 LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAE 420
LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAE
Sbjct: 361 LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAE 420
Query: 421 QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQ 480
QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQ
Sbjct: 421 QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQ 480
Query: 481 IQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKM 540
IQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKM
Sbjct: 481 IQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKM 540
Query: 541 NPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSM 600
NPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSM
Sbjct: 541 NPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSM 600
Query: 601 LLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP 650
LLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP
Sbjct: 601 LLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP 650
>gi|67782338 amyloid precursor-like protein 1 isoform 1 precursor
[Homo sapiens]
Length = 651
Score = 1316 bits (3405), Expect = 0.0
Identities = 650/651 (99%), Positives = 650/651 (99%), Gaps = 1/651 (0%)
Query: 1 MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLC 60
MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLC
Sbjct: 1 MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLC 60
Query: 61 GRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWC 120
GRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWC
Sbjct: 61 GRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWC 120
Query: 121 GGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA 180
GGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA
Sbjct: 121 GGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA 180
Query: 181 CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGA 240
CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGA
Sbjct: 181 CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGA 240
Query: 241 EDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGM 300
EDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGM
Sbjct: 241 EDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGM 300
Query: 301 PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT 360
PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT
Sbjct: 301 PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT 360
Query: 361 LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAE 420
LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAE
Sbjct: 361 LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAE 420
Query: 421 QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQ 480
QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQ
Sbjct: 421 QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQ 480
Query: 481 IQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKD-DTPMTLPKGSTEQDAASPEKEK 539
IQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKD DTPMTLPKGSTEQDAASPEKEK
Sbjct: 481 IQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDADTPMTLPKGSTEQDAASPEKEK 540
Query: 540 MNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLS 599
MNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLS
Sbjct: 541 MNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLS 600
Query: 600 MLLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP 650
MLLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP
Sbjct: 601 MLLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP 651
>gi|214010183 amyloid beta (A4) precursor-like protein 2 isoform 3
[Homo sapiens]
Length = 695
Score = 473 bits (1216), Expect = e-133
Identities = 279/690 (40%), Positives = 389/690 (56%), Gaps = 77/690 (11%)
Query: 24 LPLLLLLLRAQPAIGSLAG------GSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPD 77
L LLLL+ PA+ +LAG + G A Q+A CG+L +H +++TG+WEPD
Sbjct: 15 LLLLLLVGLTAPAL-ALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPD 73
Query: 78 PQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVP 137
P ++ C + VL+YC++MYPELQI V +A Q + ++ WC + C V P
Sbjct: 74 PTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKK-QCKSRF--VTP 130
Query: 138 FRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPC 197
F+CL GEFVS+ LLVPE C+F H+ERM+ CE+ H +EAC +QG+ L+ GMLLPC
Sbjct: 131 FKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPC 190
Query: 198 GSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEE-----ESFPQP 252
G D+F G EYVCCP +G S E EDEEE+ FP
Sbjct: 191 GVDQFHGTEYVCCPQT-------KIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTE 243
Query: 253 VD--------------------------DYFVEPPQAEE--EEETVPPPSSHTLAVVG-- 282
D DY+ + + ++ EE P S T++
Sbjct: 244 ADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEIT 303
Query: 283 ---KVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQS 339
KV PTP PT+ VD+YF + +EH F +AK LE R +++ V +EW A+ Q+
Sbjct: 304 HDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQA 363
Query: 340 KNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAAL 399
KNLPKA+RQ L +HFQ++++ LE++ + E+Q+LVETH RV A++ND+RR ALE +LAAL
Sbjct: 364 KNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAAL 423
Query: 400 QADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEER 459
Q+DPP+ R+L ALRRY+RAE K++ HT+RHYQHV AVDPEKA QM+ QV THL VIEER
Sbjct: 424 QSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEER 483
Query: 460 VNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSEL-----EAPAPGGSSEDKGGLQPPD 514
NQSL LL + P++AQE++ +I ELL + + E P S ++ PP
Sbjct: 484 RNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPF 543
Query: 515 SKDDTPMTLPK----GSTEQDAA----------SPEKEKMNPLEQYERKVNASVPRGFPF 560
LP+ G EQD S K N + V +
Sbjct: 544 HPFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERV 603
Query: 561 HSSEIQRDELAP--AGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVE 618
E +R+ + P +S A+ GLL++ ++IV+S+++L RK+ YG ISHG+VE
Sbjct: 604 GGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVML-RKRQYGTISHGIVE 662
Query: 619 VDPMLTLEEQQLRELQRHGYENPTYRFLEE 648
VDPMLT EE+ L ++Q HGYENPTY++LE+
Sbjct: 663 VDPMLTPEERHLNKMQNHGYENPTYKYLEQ 692
>gi|41406057 amyloid beta A4 protein isoform c precursor [Homo
sapiens]
Length = 695
Score = 442 bits (1136), Expect = e-124
Identities = 269/699 (38%), Positives = 381/699 (54%), Gaps = 80/699 (11%)
Query: 23 LLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSR 82
+LP L LLL A +L + G A Q+A CGRL +H +++ G+W+ DP ++
Sbjct: 1 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60
Query: 83 RCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLP 142
C+ + +L+YC+++YPELQI V +A Q + ++ WC R HPH V+P+RCL
Sbjct: 61 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHF-VIPYRCLV 119
Query: 143 GEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRF 202
GEFVS+ALLVP+ C+FLHQERMD CE+ H A+E CS + LH GMLLPCG D+F
Sbjct: 120 GEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKF 179
Query: 203 RGVEYVCCPPPGTPD--PSGTAVGDPSTRSW-------PPGSR---VEGAEDEEEEESFP 250
RGVE+VCCP D S A D S W GS VE AE+EE E
Sbjct: 180 RGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEE 239
Query: 251 QPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPT-----------------DG 293
+ DD + E EEE P T T T T D
Sbjct: 240 EEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDA 299
Query: 294 VDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEH 353
VD Y PG+ +EH F +AK LE + ++++VMREW A+ Q+KNLPKAD++A+ +H
Sbjct: 300 VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH 359
Query: 354 FQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLAL 413
FQ +++LE++ + ERQ+LVETH RV A++ND+RR ALE ++ ALQA PP+ V L
Sbjct: 360 FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML 419
Query: 414 RRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHL 473
++Y+RAEQK+++HTL+H++HV VDP+KA Q+R QV THL+VI ER+NQSL LL P +
Sbjct: 420 KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV 479
Query: 474 AQELRPQIQELLHSEH----------------------LGPSELEA-------PAPGGSS 504
A+E++ ++ ELL E L PS E P G S
Sbjct: 480 AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS 539
Query: 505 EDKGGLQPPDS--KDDTPM-------------TLPKGSTEQDAASPEKEKMNPLEQYERK 549
D LQP S D P +G T + + K + + +
Sbjct: 540 LD--DLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMD 597
Query: 550 VNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPY 609
G+ H Q+ G ++ A+ GL++ G ++IV+++++L +KK Y
Sbjct: 598 AEFRHDSGYEVHH---QKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVML-KKKQY 653
Query: 610 GAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEE 648
+I HGVVEVD +T EE+ L ++Q++GYENPTY+F E+
Sbjct: 654 TSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQ 692
>gi|209915570 amyloid beta A4 protein isoform e precursor [Homo
sapiens]
Length = 639
Score = 392 bits (1007), Expect = e-109
Identities = 244/625 (39%), Positives = 339/625 (54%), Gaps = 80/625 (12%)
Query: 97 QMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGC 156
++YPELQI V +A Q + ++ WC R HPH V+P+RCL GEFVS+ALLVP+ C
Sbjct: 19 EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHF-VIPYRCLVGEFVSDALLVPDKC 77
Query: 157 RFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTP 216
+FLHQERMD CE+ H A+E CS + LH GMLLPCG D+FRGVE+VCCP
Sbjct: 78 KFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEES 137
Query: 217 D--PSGTAVGDPSTRSW-------PPGSR---VEGAEDEEEEESFPQPVDDYFVEPPQAE 264
D S A D S W GS VE AE+EE E + DD + E
Sbjct: 138 DNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDE 197
Query: 265 EEEETVPPPSSHTLAVVGKVTPTPRPT-----------------DGVDIYFGMPGEISEH 307
EEE P T T T T D VD Y PG+ +EH
Sbjct: 198 VEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEH 257
Query: 308 EGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSG 367
F +AK LE + ++++VMREW A+ Q+KNLPKAD++A+ +HFQ +++LE++ +
Sbjct: 258 AHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAAN 317
Query: 368 ERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHT 427
ERQ+LVETH RV A++ND+RR ALE ++ ALQA PP+ V L++Y+RAEQK+++HT
Sbjct: 318 ERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHT 377
Query: 428 LRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHS 487
L+H++HV VDP+KA Q+R QV THL+VI ER+NQSL LL P +A+E++ ++ ELL
Sbjct: 378 LKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQK 437
Query: 488 EH----------------------LGPSELEA-------PAPGGSSEDKGGLQPPDS--K 516
E L PS E P G S D LQP S
Sbjct: 438 EQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLD--DLQPWHSFGA 495
Query: 517 DDTPM-------------TLPKGSTEQDAASPEKEKMNPLEQYERKVNASVPRGFPFHSS 563
D P +G T + + K + + + G+ H
Sbjct: 496 DSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHH- 554
Query: 564 EIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPML 623
Q+ G ++ A+ GL++ G ++IV+++++L +KK Y +I HGVVEVD +
Sbjct: 555 --QKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVML-KKKQYTSIHHGVVEVDAAV 611
Query: 624 TLEEQQLRELQRHGYENPTYRFLEE 648
T EE+ L ++Q++GYENPTY+F E+
Sbjct: 612 TPEERHLSKMQQNGYENPTYKFFEQ 636
>gi|41406055 amyloid beta A4 protein isoform b precursor [Homo
sapiens]
Length = 751
Score = 356 bits (913), Expect = 4e-98
Identities = 253/759 (33%), Positives = 361/759 (47%), Gaps = 144/759 (18%)
Query: 23 LLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSR 82
+LP L LLL A +L + G A Q+A CGRL +H +++ G+W+ DP ++
Sbjct: 1 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60
Query: 83 RCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLP 142
C+ + +L+YC+++YPELQI V +A Q + ++ WC R HPH V+P+RCL
Sbjct: 61 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHF-VIPYRCLV 119
Query: 143 GEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRF 202
GEFVS+ALLVP+ C+FLHQERMD CE+ H A+E CS + LH GMLLPCG D+F
Sbjct: 120 GEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKF 179
Query: 203 RGVEYVCCPPPGTPD--PSGTAVGDPSTRSW-------PPGSR---VEGAEDEEEEESFP 250
RGVE+VCCP D S A D S W GS VE AE+EE E
Sbjct: 180 RGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEE 239
Query: 251 QPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVD--------------- 295
+ DD + E EEE P T T T T+ V+
Sbjct: 240 EEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGP 299
Query: 296 -------IYFGMPGEISEHE---------GFLRAKMDLEERRMRQINEVMREWAMA---- 335
YF +++E + G R D EE M + A +
Sbjct: 300 CRAMISRWYF----DVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDA 355
Query: 336 ----------DNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ--------------- 370
+N+ + KA + +H + + Q + E ERQ
Sbjct: 356 VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH 415
Query: 371 -----------------RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLAL 413
+LVETH RV A++ND+RR ALE ++ ALQA PP+ V L
Sbjct: 416 FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML 475
Query: 414 RRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHL 473
++Y+RAEQK+++HTL+H++HV VDP+KA Q+R QV THL+VI ER+NQSL LL P +
Sbjct: 476 KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV 535
Query: 474 AQELRPQIQELLHSEH----------------------LGPSELEA-------PAPGGSS 504
A+E++ ++ ELL E L PS E P G S
Sbjct: 536 AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS 595
Query: 505 EDKGGLQPPDS--KDDTPM-------------TLPKGSTEQDAASPEKEKMNPLEQYERK 549
D LQP S D P +G T + + K + + +
Sbjct: 596 LD--DLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMD 653
Query: 550 VNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPY 609
G+ H Q+ G ++ A+ GL++ G ++IV+++++L +KK Y
Sbjct: 654 AEFRHDSGYEVHH---QKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVML-KKKQY 709
Query: 610 GAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEE 648
+I HGVVEVD +T EE+ L ++Q++GYENPTY+F E+
Sbjct: 710 TSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQ 748
>gi|214010185 amyloid beta (A4) precursor-like protein 2 isoform 4
[Homo sapiens]
Length = 522
Score = 302 bits (774), Expect = 6e-82
Identities = 171/386 (44%), Positives = 239/386 (61%), Gaps = 22/386 (5%)
Query: 284 VTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLP 343
V PTP PT+ VD+YF + +EH F +AK LE R +++ V +EW A+ Q+KNLP
Sbjct: 135 VPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLP 194
Query: 344 KADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADP 403
KA+RQ L +HFQ++++ LE++ + E+Q+LVETH RV A++ND+RR ALE +LAALQ+DP
Sbjct: 195 KAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDP 254
Query: 404 PQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQS 463
P+ R+L ALRRY+RAE K++ HT+RHYQHV AVDPEKA QM+ QV THL VIEER NQS
Sbjct: 255 PRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQS 314
Query: 464 LGLLDQNPHLAQELRPQIQELLHSEHLGPSEL-----EAPAPGGSSEDKGGLQPPDSKDD 518
L LL + P++AQE++ +I ELL + + E P S ++ PP
Sbjct: 315 LSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFH 374
Query: 519 TPMTLPK----GSTEQDAA----------SPEKEKMNPLEQYERKVNASVPRGFPFHSSE 564
LP+ G EQD S K N + V + E
Sbjct: 375 PFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLE 434
Query: 565 IQRDELAP--AGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPM 622
+R+ + P +S A+ GLL++ ++IV+S+++L RK+ YG ISHG+VEVDPM
Sbjct: 435 EERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVML-RKRQYGTISHGIVEVDPM 493
Query: 623 LTLEEQQLRELQRHGYENPTYRFLEE 648
LT EE+ L ++Q HGYENPTY++LE+
Sbjct: 494 LTPEERHLNKMQNHGYENPTYKYLEQ 519
Score = 90.9 bits (224), Expect = 3e-18
Identities = 48/124 (38%), Positives = 70/124 (56%), Gaps = 10/124 (8%)
Query: 24 LPLLLLLLRAQPAIGSLAG------GSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPD 77
L LLLL+ PA+ +LAG + G A Q+A CG+L +H +++TG+WEPD
Sbjct: 15 LLLLLLVGLTAPAL-ALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPD 73
Query: 78 PQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVP 137
P ++ C + VL+YC++MYPELQI V +A Q + ++ WC R V P
Sbjct: 74 PTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWC---RRDKKQCKSRFVTP 130
Query: 138 FRCL 141
F+CL
Sbjct: 131 FKCL 134
>gi|4502147 amyloid beta (A4) precursor-like protein 2 isoform 1
[Homo sapiens]
Length = 763
Score = 302 bits (774), Expect = 6e-82
Identities = 172/398 (43%), Positives = 243/398 (61%), Gaps = 34/398 (8%)
Query: 284 VTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLP 343
+ PTP PT+ VD+YF + +EH F +AK LE R +++ V +EW A+ Q+KNLP
Sbjct: 364 IPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLP 423
Query: 344 KADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADP 403
KA+RQ L +HFQ++++ LE++ + E+Q+LVETH RV A++ND+RR ALE +LAALQ+DP
Sbjct: 424 KAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDP 483
Query: 404 PQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQS 463
P+ R+L ALRRY+RAE K++ HT+RHYQHV AVDPEKA QM+ QV THL VIEER NQS
Sbjct: 484 PRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQS 543
Query: 464 LGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGG------SSEDKGGLQP----- 512
L LL + P++AQE++ +I ELL + + A SSE+ + P
Sbjct: 544 LSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFH 603
Query: 513 -----PDSKDDT-----PMTLPKGSTEQDAA----------SPEKEKMNPLEQYERKVNA 552
P+++D PM G EQD S K N + V
Sbjct: 604 PFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKE 663
Query: 553 SVPRGFPFHSSEIQRDELAP--AGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYG 610
+ E +R+ + P +S A+ GLL++ ++IV+S+++L RK+ YG
Sbjct: 664 MIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVML-RKRQYG 722
Query: 611 AISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEE 648
ISHG+VEVDPMLT EE+ L ++Q HGYENPTY++LE+
Sbjct: 723 TISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQ 760
Score = 188 bits (478), Expect = 1e-47
Identities = 104/257 (40%), Positives = 143/257 (55%), Gaps = 23/257 (8%)
Query: 24 LPLLLLLLRAQPAIGSLAG------GSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPD 77
L LLLL+ PA+ +LAG + G A Q+A CG+L +H +++TG+WEPD
Sbjct: 15 LLLLLLVGLTAPAL-ALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPD 73
Query: 78 PQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVP 137
P ++ C + VL+YC++MYPELQI V +A Q + ++ WC + C V P
Sbjct: 74 PTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKK-QCKSRF--VTP 130
Query: 138 FRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPC 197
F+CL GEFVS+ LLVPE C+F H+ERM+ CE+ H +EAC +QG+ L+ GMLLPC
Sbjct: 131 FKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPC 190
Query: 198 GSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEE-----ESFPQP 252
G D+F G EYVCC P +G S E EDEEE+ FP
Sbjct: 191 GVDQFHGTEYVCC-------PQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTE 243
Query: 253 VD-DYFVEPPQAEEEEE 268
D + F E E++E+
Sbjct: 244 ADLEDFTEAAVDEDDED 260
>gi|214010181 amyloid beta (A4) precursor-like protein 2 isoform 2
[Homo sapiens]
Length = 751
Score = 302 bits (773), Expect = 7e-82
Identities = 170/386 (44%), Positives = 239/386 (61%), Gaps = 22/386 (5%)
Query: 284 VTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLP 343
+ PTP PT+ VD+YF + +EH F +AK LE R +++ V +EW A+ Q+KNLP
Sbjct: 364 IPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLP 423
Query: 344 KADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADP 403
KA+RQ L +HFQ++++ LE++ + E+Q+LVETH RV A++ND+RR ALE +LAALQ+DP
Sbjct: 424 KAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDP 483
Query: 404 PQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQS 463
P+ R+L ALRRY+RAE K++ HT+RHYQHV AVDPEKA QM+ QV THL VIEER NQS
Sbjct: 484 PRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQS 543
Query: 464 LGLLDQNPHLAQELRPQIQELLHSEHLGPSEL-----EAPAPGGSSEDKGGLQPPDSKDD 518
L LL + P++AQE++ +I ELL + + E P S ++ PP
Sbjct: 544 LSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFH 603
Query: 519 TPMTLPK----GSTEQDAA----------SPEKEKMNPLEQYERKVNASVPRGFPFHSSE 564
LP+ G EQD S K N + V + E
Sbjct: 604 PFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLE 663
Query: 565 IQRDELAP--AGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPM 622
+R+ + P +S A+ GLL++ ++IV+S+++L RK+ YG ISHG+VEVDPM
Sbjct: 664 EERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVML-RKRQYGTISHGIVEVDPM 722
Query: 623 LTLEEQQLRELQRHGYENPTYRFLEE 648
LT EE+ L ++Q HGYENPTY++LE+
Sbjct: 723 LTPEERHLNKMQNHGYENPTYKYLEQ 748
Score = 188 bits (478), Expect = 1e-47
Identities = 104/257 (40%), Positives = 143/257 (55%), Gaps = 23/257 (8%)
Query: 24 LPLLLLLLRAQPAIGSLAG------GSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPD 77
L LLLL+ PA+ +LAG + G A Q+A CG+L +H +++TG+WEPD
Sbjct: 15 LLLLLLVGLTAPAL-ALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPD 73
Query: 78 PQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVP 137
P ++ C + VL+YC++MYPELQI V +A Q + ++ WC + C V P
Sbjct: 74 PTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKK-QCKSRF--VTP 130
Query: 138 FRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPC 197
F+CL GEFVS+ LLVPE C+F H+ERM+ CE+ H +EAC +QG+ L+ GMLLPC
Sbjct: 131 FKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPC 190
Query: 198 GSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEE-----ESFPQP 252
G D+F G EYVCC P +G S E EDEEE+ FP
Sbjct: 191 GVDQFHGTEYVCC-------PQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTE 243
Query: 253 VD-DYFVEPPQAEEEEE 268
D + F E E++E+
Sbjct: 244 ADLEDFTEAAVDEDDED 260
>gi|4502167 amyloid beta A4 protein isoform a precursor [Homo
sapiens]
Length = 770
Score = 254 bits (648), Expect = 2e-67
Identities = 153/401 (38%), Positives = 229/401 (57%), Gaps = 50/401 (12%)
Query: 292 DGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALN 351
D VD Y PG+ +EH F +AK LE + ++++VMREW A+ Q+KNLPKAD++A+
Sbjct: 373 DAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVI 432
Query: 352 EHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLL 411
+HFQ +++LE++ + ERQ+LVETH RV A++ND+RR ALE ++ ALQA PP+ V
Sbjct: 433 QHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFN 492
Query: 412 ALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNP 471
L++Y+RAEQK+++HTL+H++HV VDP+KA Q+R QV THL+VI ER+NQSL LL P
Sbjct: 493 MLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVP 552
Query: 472 HLAQELRPQIQELLHSEH----------------------LGPSELEA-------PAPGG 502
+A+E++ ++ ELL E L PS E P G
Sbjct: 553 AVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGE 612
Query: 503 SSEDKGGLQPPDS--KDDTPM-------------TLPKGSTEQDAASPEKEKMNPLEQYE 547
S D LQP S D P +G T + + K + + +
Sbjct: 613 FSLD--DLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVK 670
Query: 548 RKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKK 607
G+ H Q+ G ++ A+ GL++ G ++IV+++++L +KK
Sbjct: 671 MDAEFRHDSGYEVHH---QKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVML-KKK 726
Query: 608 PYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEE 648
Y +I HGVVEVD +T EE+ L ++Q++GYENPTY+F E+
Sbjct: 727 QYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQ 767
Score = 210 bits (535), Expect = 3e-54
Identities = 157/488 (32%), Positives = 232/488 (47%), Gaps = 53/488 (10%)
Query: 23 LLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSR 82
+LP L LLL A +L + G A Q+A CGRL +H +++ G+W+ DP ++
Sbjct: 1 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60
Query: 83 RCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLP 142
C+ + +L+YC+++YPELQI V +A Q + ++ WC R HPH V+P+RCL
Sbjct: 61 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHF-VIPYRCLV 119
Query: 143 GEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRF 202
GEFVS+ALLVP+ C+FLHQERMD CE+ H A+E CS + LH GMLLPCG D+F
Sbjct: 120 GEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKF 179
Query: 203 RGVEYVCCPPPGTPD--PSGTAVGDPSTRSW-------PPGSR---VEGAEDEEEEESFP 250
RGVE+VCCP D S A D S W GS VE AE+EE E
Sbjct: 180 RGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEE 239
Query: 251 QPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGF 310
+ DD + E EEE P T T T T+ V+ G
Sbjct: 240 EEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGP 299
Query: 311 LRAKM-----DLEERRM----------RQINEVMREWAMADNQSKNLPKADRQALNEHFQ 355
RA + D+ E + + N E+ MA S A++ Q
Sbjct: 300 CRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGS---------AMS---Q 347
Query: 356 SILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQ-----ADPPQAERVL 410
S+L+T +E ++ + +L T A+ A+ E A Q + ER+
Sbjct: 348 SLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMS 407
Query: 411 LALRRYLRAEQK-------EQRHTLRHYQH-VAAVDPEKAQQMRFQVHTHLQVIEERVNQ 462
+R + AE++ +++ ++H+Q V +++ E A + + V TH+ +E +N
Sbjct: 408 QVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLND 467
Query: 463 SLGLLDQN 470
L +N
Sbjct: 468 RRRLALEN 475
>gi|209915573 amyloid beta A4 protein isoform f precursor [Homo
sapiens]
Length = 714
Score = 254 bits (648), Expect = 2e-67
Identities = 153/401 (38%), Positives = 229/401 (57%), Gaps = 50/401 (12%)
Query: 292 DGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALN 351
D VD Y PG+ +EH F +AK LE + ++++VMREW A+ Q+KNLPKAD++A+
Sbjct: 317 DAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVI 376
Query: 352 EHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLL 411
+HFQ +++LE++ + ERQ+LVETH RV A++ND+RR ALE ++ ALQA PP+ V
Sbjct: 377 QHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFN 436
Query: 412 ALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNP 471
L++Y+RAEQK+++HTL+H++HV VDP+KA Q+R QV THL+VI ER+NQSL LL P
Sbjct: 437 MLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVP 496
Query: 472 HLAQELRPQIQELLHSEH----------------------LGPSELEA-------PAPGG 502
+A+E++ ++ ELL E L PS E P G
Sbjct: 497 AVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGE 556
Query: 503 SSEDKGGLQPPDS--KDDTPM-------------TLPKGSTEQDAASPEKEKMNPLEQYE 547
S D LQP S D P +G T + + K + + +
Sbjct: 557 FSLD--DLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVK 614
Query: 548 RKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKK 607
G+ H Q+ G ++ A+ GL++ G ++IV+++++L +KK
Sbjct: 615 MDAEFRHDSGYEVHH---QKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVML-KKK 670
Query: 608 PYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEE 648
Y +I HGVVEVD +T EE+ L ++Q++GYENPTY+F E+
Sbjct: 671 QYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQ 711
Score = 160 bits (406), Expect = 3e-39
Identities = 132/414 (31%), Positives = 190/414 (45%), Gaps = 53/414 (12%)
Query: 97 QMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGC 156
++YPELQI V +A Q + ++ WC R HPH V+P+RCL GEFVS+ALLVP+ C
Sbjct: 19 EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHF-VIPYRCLVGEFVSDALLVPDKC 77
Query: 157 RFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTP 216
+FLHQERMD CE+ H A+E CS + LH GMLLPCG D+FRGVE+VCCP
Sbjct: 78 KFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEES 137
Query: 217 D--PSGTAVGDPSTRSW-------PPGSR---VEGAEDEEEEESFPQPVDDYFVEPPQAE 264
D S A D S W GS VE AE+EE E + DD + E
Sbjct: 138 DNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDE 197
Query: 265 EEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKM-----DLEE 319
EEE P T T T T+ V+ G RA + D+ E
Sbjct: 198 VEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTE 257
Query: 320 RRM----------RQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGER 369
+ + N E+ MA S A++ QS+L+T +E ++ +
Sbjct: 258 GKCAPFFYGGCGGNRNNFDTEEYCMAVCGS---------AMS---QSLLKTTQEPLARDP 305
Query: 370 QRLVETHATRVIALINDQRRAALEGFLAALQ-----ADPPQAERVLLALRRYLRAEQK-- 422
+L T A+ A+ E A Q + ER+ +R + AE++
Sbjct: 306 VKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAK 365
Query: 423 -----EQRHTLRHYQH-VAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQN 470
+++ ++H+Q V +++ E A + + V TH+ +E +N L +N
Sbjct: 366 NLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALEN 419
>gi|91208420 bassoon protein [Homo sapiens]
Length = 3926
Score = 44.7 bits (104), Expect = 3e-04
Identities = 43/172 (25%), Positives = 70/172 (40%), Gaps = 19/172 (11%)
Query: 444 QMRFQVHTHLQVIEE------RVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEA 497
Q F + HL ++E ++ ++LG+ + R + Q+ LHS L P+ A
Sbjct: 200 QCGFNPNPHLTQVKEWLCLNCQMQRALGM-----DMTTAPRSKSQQQLHSPALSPAHSPA 254
Query: 498 PAPGGSSEDK-----GGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKVNA 552
P G + + GG QP + +T Q AA PE +++P K +
Sbjct: 255 KQPLGKPDQERSRGPGGPQPGSRQAETARATSVPGPAQAAAPPEVGRVSPQPPQPTKPST 314
Query: 553 SVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLL--IMGAGGGSLIVLSMLL 602
+ PR P + + PAG G + + GL + G G L S L+
Sbjct: 315 AEPRP-PAGEAPAKSATAVPAGLGATEQTQEGLTGKLFGLGASLLTQASTLM 365
Score = 32.0 bits (71), Expect = 1.8
Identities = 34/141 (24%), Positives = 57/141 (40%), Gaps = 11/141 (7%)
Query: 362 EEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQ 421
EE ERQR + ++ ++ R LE + + ERV L R +
Sbjct: 2357 EEASQEERQRKQQEQLLQL-----ERERVELEKLRQLRLQEELERERVELQRHR-----E 2406
Query: 422 KEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQI 481
+EQ R Q + + QQ + + + E++ Q L+Q L Q+L+ Q+
Sbjct: 2407 EEQLLVQRELQELQTIKHHVLQQQQEERQAQFALQREQLAQQRLQLEQIQQLQQQLQQQL 2466
Query: 482 QELLHSEHLG-PSELEAPAPG 501
+E + P+ EAP G
Sbjct: 2467 EEQKQRQKAPFPAACEAPGRG 2487
Score = 30.4 bits (67), Expect = 5.3
Identities = 35/114 (30%), Positives = 47/114 (41%), Gaps = 13/114 (11%)
Query: 5 SPAARGLSRRPGQP-------PLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVA 57
+P A G SR P P PLP P + PA LAG P A APG +
Sbjct: 2290 APGAGGPSR-PEMPVGAAREEPLPTTTPAAIKEAAGAPAPAPLAGQKPPADAAPGGG--S 2346
Query: 58 GLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQRV-LEYCRQ--MYPELQIARVE 108
G R ++ + Q+ + + +RV LE RQ + EL+ RVE
Sbjct: 2347 GALSRPGFEKEEASQEERQRKQQEQLLQLERERVELEKLRQLRLQEELERERVE 2400
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 42.4 bits (98), Expect = 0.001
Identities = 58/242 (23%), Positives = 104/242 (42%), Gaps = 25/242 (10%)
Query: 312 RAKMDLEERRMRQ-INEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ 370
R + D + R+R+ I E+ RE ++K L Q +E Q++ Q EQ+ E Q
Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLL-----QLKSEEMQTVQQ---EQLLQETQ 2489
Query: 371 RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRH 430
L ++ + +L+ +R F+ +A Q + +A + LR EQ+ Q+ +
Sbjct: 2490 ALQQSFLSEKDSLLQRER------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543
Query: 431 YQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHL 490
+ E+A++ + + ++ +E + Q L+Q +EL + + L E L
Sbjct: 2544 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLR-EQL 2598
Query: 491 GPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKV 550
E + A SE+ Q +K TLP G D + E E + + RKV
Sbjct: 2599 QLLEEQHRAALAHSEEVTASQVAATK-----TLPNGRDALDGPAAEAEPEHSFDGLRRKV 2653
Query: 551 NA 552
+A
Sbjct: 2654 SA 2655
Score = 38.1 bits (87), Expect = 0.026
Identities = 47/194 (24%), Positives = 74/194 (38%), Gaps = 17/194 (8%)
Query: 306 EHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEE-- 363
E E R + ER RQ+ + + A+ + + KA+ +A E Q LQ LEE
Sbjct: 1484 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELR 1542
Query: 364 -QVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQK 422
Q +RL + R Q + ALE + +A+ L +R AE+
Sbjct: 1543 LQAEEAERRLRQAEVERA-----RQVQVALETAQRSAEAE--------LQSKRASFAEKT 1589
Query: 423 EQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQ 482
Q +HVA + + R Q + E + L + A LR Q +
Sbjct: 1590 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1649
Query: 483 ELLHSEHLGPSELE 496
E+ + L +E E
Sbjct: 1650 EVAQQKSLAQAEAE 1663
Score = 35.8 bits (81), Expect = 0.13
Identities = 41/160 (25%), Positives = 70/160 (43%), Gaps = 17/160 (10%)
Query: 312 RAKMDLEERRMRQINEVMR--EWAMADNQSKNLPKADRQALNEHFQSILQTLEEQV-SGE 368
+A+ + +E + R EV+R E A+ Q K + + Q L + ++ +Q Q + E
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1444
Query: 369 RQRLVETHATRVIAL---INDQRRAALEGFLAAL-------QADPPQAERVLLALRRYLR 418
R RL RV+ L +++R EG L AL +A QA+ LRR ++
Sbjct: 1445 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1504
Query: 419 AEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEE 458
E + +R + E A++ + LQ +EE
Sbjct: 1505 DESQRKRQAEVELASRVKAEAEAAREKQ----RALQALEE 1540
Score = 33.5 bits (75), Expect = 0.63
Identities = 47/204 (23%), Positives = 86/204 (42%), Gaps = 25/204 (12%)
Query: 311 LRAKMDLEERRMRQI--NEVMREWAMADNQSKNLPKADRQA----LNEHFQSILQTLEEQ 364
L+AK++ E RR+R+ E R+ +A ++ +A+ +A + + Q + QTL+++
Sbjct: 2014 LKAKVE-EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2072
Query: 365 VSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRA----- 419
S Q E A R A ++ R E A + +AER+ + +A
Sbjct: 2073 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2132
Query: 420 -------EQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPH 472
++ EQ R AA+ ++A + H ++ Q+L Q
Sbjct: 2133 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH------KKFAEQTLRQKAQVEQ 2186
Query: 473 LAQELRPQIQELLHSEHLGPSELE 496
LR Q++E H ++L EL+
Sbjct: 2187 ELTTLRLQLEETDHQKNLLDEELQ 2210
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 42.4 bits (98), Expect = 0.001
Identities = 58/242 (23%), Positives = 104/242 (42%), Gaps = 25/242 (10%)
Query: 312 RAKMDLEERRMRQ-INEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ 370
R + D + R+R+ I E+ RE ++K L Q +E Q++ Q EQ+ E Q
Sbjct: 2442 RQQSDHDAERLREAIAELEREKEKLQQEAKLL-----QLKSEEMQTVQQ---EQLLQETQ 2493
Query: 371 RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRH 430
L ++ + +L+ +R F+ +A Q + +A + LR EQ+ Q+ +
Sbjct: 2494 ALQQSFLSEKDSLLQRER------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2547
Query: 431 YQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHL 490
+ E+A++ + + ++ +E + Q L+Q +EL + + L E L
Sbjct: 2548 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLR-EQL 2602
Query: 491 GPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKV 550
E + A SE+ Q +K TLP G D + E E + + RKV
Sbjct: 2603 QLLEEQHRAALAHSEEVTASQVAATK-----TLPNGRDALDGPAAEAEPEHSFDGLRRKV 2657
Query: 551 NA 552
+A
Sbjct: 2658 SA 2659
Score = 38.1 bits (87), Expect = 0.026
Identities = 47/194 (24%), Positives = 74/194 (38%), Gaps = 17/194 (8%)
Query: 306 EHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEE-- 363
E E R + ER RQ+ + + A+ + + KA+ +A E Q LQ LEE
Sbjct: 1488 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELR 1546
Query: 364 -QVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQK 422
Q +RL + R Q + ALE + +A+ L +R AE+
Sbjct: 1547 LQAEEAERRLRQAEVERA-----RQVQVALETAQRSAEAE--------LQSKRASFAEKT 1593
Query: 423 EQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQ 482
Q +HVA + + R Q + E + L + A LR Q +
Sbjct: 1594 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1653
Query: 483 ELLHSEHLGPSELE 496
E+ + L +E E
Sbjct: 1654 EVAQQKSLAQAEAE 1667
Score = 35.8 bits (81), Expect = 0.13
Identities = 41/160 (25%), Positives = 70/160 (43%), Gaps = 17/160 (10%)
Query: 312 RAKMDLEERRMRQINEVMR--EWAMADNQSKNLPKADRQALNEHFQSILQTLEEQV-SGE 368
+A+ + +E + R EV+R E A+ Q K + + Q L + ++ +Q Q + E
Sbjct: 1389 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1448
Query: 369 RQRLVETHATRVIAL---INDQRRAALEGFLAAL-------QADPPQAERVLLALRRYLR 418
R RL RV+ L +++R EG L AL +A QA+ LRR ++
Sbjct: 1449 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1508
Query: 419 AEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEE 458
E + +R + E A++ + LQ +EE
Sbjct: 1509 DESQRKRQAEVELASRVKAEAEAAREKQ----RALQALEE 1544
Score = 33.5 bits (75), Expect = 0.63
Identities = 47/204 (23%), Positives = 86/204 (42%), Gaps = 25/204 (12%)
Query: 311 LRAKMDLEERRMRQI--NEVMREWAMADNQSKNLPKADRQA----LNEHFQSILQTLEEQ 364
L+AK++ E RR+R+ E R+ +A ++ +A+ +A + + Q + QTL+++
Sbjct: 2018 LKAKVE-EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2076
Query: 365 VSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRA----- 419
S Q E A R A ++ R E A + +AER+ + +A
Sbjct: 2077 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2136
Query: 420 -------EQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPH 472
++ EQ R AA+ ++A + H ++ Q+L Q
Sbjct: 2137 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH------KKFAEQTLRQKAQVEQ 2190
Query: 473 LAQELRPQIQELLHSEHLGPSELE 496
LR Q++E H ++L EL+
Sbjct: 2191 ELTTLRLQLEETDHQKNLLDEELQ 2214
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 42.4 bits (98), Expect = 0.001
Identities = 58/242 (23%), Positives = 104/242 (42%), Gaps = 25/242 (10%)
Query: 312 RAKMDLEERRMRQ-INEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ 370
R + D + R+R+ I E+ RE ++K L Q +E Q++ Q EQ+ E Q
Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLL-----QLKSEEMQTVQQ---EQLLQETQ 2489
Query: 371 RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRH 430
L ++ + +L+ +R F+ +A Q + +A + LR EQ+ Q+ +
Sbjct: 2490 ALQQSFLSEKDSLLQRER------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543
Query: 431 YQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHL 490
+ E+A++ + + ++ +E + Q L+Q +EL + + L E L
Sbjct: 2544 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLR-EQL 2598
Query: 491 GPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKV 550
E + A SE+ Q +K TLP G D + E E + + RKV
Sbjct: 2599 QLLEEQHRAALAHSEEVTASQVAATK-----TLPNGRDALDGPAAEAEPEHSFDGLRRKV 2653
Query: 551 NA 552
+A
Sbjct: 2654 SA 2655
Score = 38.1 bits (87), Expect = 0.026
Identities = 47/194 (24%), Positives = 74/194 (38%), Gaps = 17/194 (8%)
Query: 306 EHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEE-- 363
E E R + ER RQ+ + + A+ + + KA+ +A E Q LQ LEE
Sbjct: 1484 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELR 1542
Query: 364 -QVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQK 422
Q +RL + R Q + ALE + +A+ L +R AE+
Sbjct: 1543 LQAEEAERRLRQAEVERA-----RQVQVALETAQRSAEAE--------LQSKRASFAEKT 1589
Query: 423 EQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQ 482
Q +HVA + + R Q + E + L + A LR Q +
Sbjct: 1590 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1649
Query: 483 ELLHSEHLGPSELE 496
E+ + L +E E
Sbjct: 1650 EVAQQKSLAQAEAE 1663
Score = 35.8 bits (81), Expect = 0.13
Identities = 41/160 (25%), Positives = 70/160 (43%), Gaps = 17/160 (10%)
Query: 312 RAKMDLEERRMRQINEVMR--EWAMADNQSKNLPKADRQALNEHFQSILQTLEEQV-SGE 368
+A+ + +E + R EV+R E A+ Q K + + Q L + ++ +Q Q + E
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1444
Query: 369 RQRLVETHATRVIAL---INDQRRAALEGFLAAL-------QADPPQAERVLLALRRYLR 418
R RL RV+ L +++R EG L AL +A QA+ LRR ++
Sbjct: 1445 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1504
Query: 419 AEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEE 458
E + +R + E A++ + LQ +EE
Sbjct: 1505 DESQRKRQAEVELASRVKAEAEAAREKQ----RALQALEE 1540
Score = 33.5 bits (75), Expect = 0.63
Identities = 47/204 (23%), Positives = 86/204 (42%), Gaps = 25/204 (12%)
Query: 311 LRAKMDLEERRMRQI--NEVMREWAMADNQSKNLPKADRQA----LNEHFQSILQTLEEQ 364
L+AK++ E RR+R+ E R+ +A ++ +A+ +A + + Q + QTL+++
Sbjct: 2014 LKAKVE-EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2072
Query: 365 VSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRA----- 419
S Q E A R A ++ R E A + +AER+ + +A
Sbjct: 2073 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2132
Query: 420 -------EQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPH 472
++ EQ R AA+ ++A + H ++ Q+L Q
Sbjct: 2133 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH------KKFAEQTLRQKAQVEQ 2186
Query: 473 LAQELRPQIQELLHSEHLGPSELE 496
LR Q++E H ++L EL+
Sbjct: 2187 ELTTLRLQLEETDHQKNLLDEELQ 2210
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 42.4 bits (98), Expect = 0.001
Identities = 58/242 (23%), Positives = 104/242 (42%), Gaps = 25/242 (10%)
Query: 312 RAKMDLEERRMRQ-INEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ 370
R + D + R+R+ I E+ RE ++K L Q +E Q++ Q EQ+ E Q
Sbjct: 2406 RQQSDHDAERLREAIAELEREKEKLQQEAKLL-----QLKSEEMQTVQQ---EQLLQETQ 2457
Query: 371 RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRH 430
L ++ + +L+ +R F+ +A Q + +A + LR EQ+ Q+ +
Sbjct: 2458 ALQQSFLSEKDSLLQRER------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2511
Query: 431 YQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHL 490
+ E+A++ + + ++ +E + Q L+Q +EL + + L E L
Sbjct: 2512 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLR-EQL 2566
Query: 491 GPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKV 550
E + A SE+ Q +K TLP G D + E E + + RKV
Sbjct: 2567 QLLEEQHRAALAHSEEVTASQVAATK-----TLPNGRDALDGPAAEAEPEHSFDGLRRKV 2621
Query: 551 NA 552
+A
Sbjct: 2622 SA 2623
Score = 38.1 bits (87), Expect = 0.026
Identities = 47/194 (24%), Positives = 74/194 (38%), Gaps = 17/194 (8%)
Query: 306 EHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEE-- 363
E E R + ER RQ+ + + A+ + + KA+ +A E Q LQ LEE
Sbjct: 1452 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELR 1510
Query: 364 -QVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQK 422
Q +RL + R Q + ALE + +A+ L +R AE+
Sbjct: 1511 LQAEEAERRLRQAEVERA-----RQVQVALETAQRSAEAE--------LQSKRASFAEKT 1557
Query: 423 EQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQ 482
Q +HVA + + R Q + E + L + A LR Q +
Sbjct: 1558 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1617
Query: 483 ELLHSEHLGPSELE 496
E+ + L +E E
Sbjct: 1618 EVAQQKSLAQAEAE 1631
Score = 35.8 bits (81), Expect = 0.13
Identities = 41/160 (25%), Positives = 70/160 (43%), Gaps = 17/160 (10%)
Query: 312 RAKMDLEERRMRQINEVMR--EWAMADNQSKNLPKADRQALNEHFQSILQTLEEQV-SGE 368
+A+ + +E + R EV+R E A+ Q K + + Q L + ++ +Q Q + E
Sbjct: 1353 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1412
Query: 369 RQRLVETHATRVIAL---INDQRRAALEGFLAAL-------QADPPQAERVLLALRRYLR 418
R RL RV+ L +++R EG L AL +A QA+ LRR ++
Sbjct: 1413 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1472
Query: 419 AEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEE 458
E + +R + E A++ + LQ +EE
Sbjct: 1473 DESQRKRQAEVELASRVKAEAEAAREKQ----RALQALEE 1508
Score = 33.5 bits (75), Expect = 0.63
Identities = 47/204 (23%), Positives = 86/204 (42%), Gaps = 25/204 (12%)
Query: 311 LRAKMDLEERRMRQI--NEVMREWAMADNQSKNLPKADRQA----LNEHFQSILQTLEEQ 364
L+AK++ E RR+R+ E R+ +A ++ +A+ +A + + Q + QTL+++
Sbjct: 1982 LKAKVE-EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2040
Query: 365 VSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRA----- 419
S Q E A R A ++ R E A + +AER+ + +A
Sbjct: 2041 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2100
Query: 420 -------EQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPH 472
++ EQ R AA+ ++A + H ++ Q+L Q
Sbjct: 2101 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH------KKFAEQTLRQKAQVEQ 2154
Query: 473 LAQELRPQIQELLHSEHLGPSELE 496
LR Q++E H ++L EL+
Sbjct: 2155 ELTTLRLQLEETDHQKNLLDEELQ 2178
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 42.4 bits (98), Expect = 0.001
Identities = 58/242 (23%), Positives = 104/242 (42%), Gaps = 25/242 (10%)
Query: 312 RAKMDLEERRMRQ-INEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ 370
R + D + R+R+ I E+ RE ++K L Q +E Q++ Q EQ+ E Q
Sbjct: 2575 RQQSDHDAERLREAIAELEREKEKLQQEAKLL-----QLKSEEMQTVQQ---EQLLQETQ 2626
Query: 371 RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRH 430
L ++ + +L+ +R F+ +A Q + +A + LR EQ+ Q+ +
Sbjct: 2627 ALQQSFLSEKDSLLQRER------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2680
Query: 431 YQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHL 490
+ E+A++ + + ++ +E + Q L+Q +EL + + L E L
Sbjct: 2681 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLR-EQL 2735
Query: 491 GPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKV 550
E + A SE+ Q +K TLP G D + E E + + RKV
Sbjct: 2736 QLLEEQHRAALAHSEEVTASQVAATK-----TLPNGRDALDGPAAEAEPEHSFDGLRRKV 2790
Query: 551 NA 552
+A
Sbjct: 2791 SA 2792
Score = 38.1 bits (87), Expect = 0.026
Identities = 47/194 (24%), Positives = 74/194 (38%), Gaps = 17/194 (8%)
Query: 306 EHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEE-- 363
E E R + ER RQ+ + + A+ + + KA+ +A E Q LQ LEE
Sbjct: 1621 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELR 1679
Query: 364 -QVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQK 422
Q +RL + R Q + ALE + +A+ L +R AE+
Sbjct: 1680 LQAEEAERRLRQAEVERA-----RQVQVALETAQRSAEAE--------LQSKRASFAEKT 1726
Query: 423 EQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQ 482
Q +HVA + + R Q + E + L + A LR Q +
Sbjct: 1727 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1786
Query: 483 ELLHSEHLGPSELE 496
E+ + L +E E
Sbjct: 1787 EVAQQKSLAQAEAE 1800
Score = 35.8 bits (81), Expect = 0.13
Identities = 41/160 (25%), Positives = 70/160 (43%), Gaps = 17/160 (10%)
Query: 312 RAKMDLEERRMRQINEVMR--EWAMADNQSKNLPKADRQALNEHFQSILQTLEEQV-SGE 368
+A+ + +E + R EV+R E A+ Q K + + Q L + ++ +Q Q + E
Sbjct: 1522 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1581
Query: 369 RQRLVETHATRVIAL---INDQRRAALEGFLAAL-------QADPPQAERVLLALRRYLR 418
R RL RV+ L +++R EG L AL +A QA+ LRR ++
Sbjct: 1582 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1641
Query: 419 AEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEE 458
E + +R + E A++ + LQ +EE
Sbjct: 1642 DESQRKRQAEVELASRVKAEAEAAREKQ----RALQALEE 1677
Score = 33.5 bits (75), Expect = 0.63
Identities = 47/204 (23%), Positives = 86/204 (42%), Gaps = 25/204 (12%)
Query: 311 LRAKMDLEERRMRQI--NEVMREWAMADNQSKNLPKADRQA----LNEHFQSILQTLEEQ 364
L+AK++ E RR+R+ E R+ +A ++ +A+ +A + + Q + QTL+++
Sbjct: 2151 LKAKVE-EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2209
Query: 365 VSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRA----- 419
S Q E A R A ++ R E A + +AER+ + +A
Sbjct: 2210 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2269
Query: 420 -------EQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPH 472
++ EQ R AA+ ++A + H ++ Q+L Q
Sbjct: 2270 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH------KKFAEQTLRQKAQVEQ 2323
Query: 473 LAQELRPQIQELLHSEHLGPSELE 496
LR Q++E H ++L EL+
Sbjct: 2324 ELTTLRLQLEETDHQKNLLDEELQ 2347
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 42.4 bits (98), Expect = 0.001
Identities = 58/242 (23%), Positives = 104/242 (42%), Gaps = 25/242 (10%)
Query: 312 RAKMDLEERRMRQ-INEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ 370
R + D + R+R+ I E+ RE ++K L Q +E Q++ Q EQ+ E Q
Sbjct: 2416 RQQSDHDAERLREAIAELEREKEKLQQEAKLL-----QLKSEEMQTVQQ---EQLLQETQ 2467
Query: 371 RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRH 430
L ++ + +L+ +R F+ +A Q + +A + LR EQ+ Q+ +
Sbjct: 2468 ALQQSFLSEKDSLLQRER------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2521
Query: 431 YQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHL 490
+ E+A++ + + ++ +E + Q L+Q +EL + + L E L
Sbjct: 2522 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLR-EQL 2576
Query: 491 GPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKV 550
E + A SE+ Q +K TLP G D + E E + + RKV
Sbjct: 2577 QLLEEQHRAALAHSEEVTASQVAATK-----TLPNGRDALDGPAAEAEPEHSFDGLRRKV 2631
Query: 551 NA 552
+A
Sbjct: 2632 SA 2633
Score = 38.1 bits (87), Expect = 0.026
Identities = 47/194 (24%), Positives = 74/194 (38%), Gaps = 17/194 (8%)
Query: 306 EHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEE-- 363
E E R + ER RQ+ + + A+ + + KA+ +A E Q LQ LEE
Sbjct: 1462 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELR 1520
Query: 364 -QVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQK 422
Q +RL + R Q + ALE + +A+ L +R AE+
Sbjct: 1521 LQAEEAERRLRQAEVERA-----RQVQVALETAQRSAEAE--------LQSKRASFAEKT 1567
Query: 423 EQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQ 482
Q +HVA + + R Q + E + L + A LR Q +
Sbjct: 1568 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1627
Query: 483 ELLHSEHLGPSELE 496
E+ + L +E E
Sbjct: 1628 EVAQQKSLAQAEAE 1641
Score = 35.8 bits (81), Expect = 0.13
Identities = 41/160 (25%), Positives = 70/160 (43%), Gaps = 17/160 (10%)
Query: 312 RAKMDLEERRMRQINEVMR--EWAMADNQSKNLPKADRQALNEHFQSILQTLEEQV-SGE 368
+A+ + +E + R EV+R E A+ Q K + + Q L + ++ +Q Q + E
Sbjct: 1363 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1422
Query: 369 RQRLVETHATRVIAL---INDQRRAALEGFLAAL-------QADPPQAERVLLALRRYLR 418
R RL RV+ L +++R EG L AL +A QA+ LRR ++
Sbjct: 1423 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1482
Query: 419 AEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEE 458
E + +R + E A++ + LQ +EE
Sbjct: 1483 DESQRKRQAEVELASRVKAEAEAAREKQ----RALQALEE 1518
Score = 33.5 bits (75), Expect = 0.63
Identities = 47/204 (23%), Positives = 86/204 (42%), Gaps = 25/204 (12%)
Query: 311 LRAKMDLEERRMRQI--NEVMREWAMADNQSKNLPKADRQA----LNEHFQSILQTLEEQ 364
L+AK++ E RR+R+ E R+ +A ++ +A+ +A + + Q + QTL+++
Sbjct: 1992 LKAKVE-EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2050
Query: 365 VSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRA----- 419
S Q E A R A ++ R E A + +AER+ + +A
Sbjct: 2051 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2110
Query: 420 -------EQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPH 472
++ EQ R AA+ ++A + H ++ Q+L Q
Sbjct: 2111 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH------KKFAEQTLRQKAQVEQ 2164
Query: 473 LAQELRPQIQELLHSEHLGPSELE 496
LR Q++E H ++L EL+
Sbjct: 2165 ELTTLRLQLEETDHQKNLLDEELQ 2188
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 42.4 bits (98), Expect = 0.001
Identities = 58/242 (23%), Positives = 104/242 (42%), Gaps = 25/242 (10%)
Query: 312 RAKMDLEERRMRQ-INEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ 370
R + D + R+R+ I E+ RE ++K L Q +E Q++ Q EQ+ E Q
Sbjct: 2424 RQQSDHDAERLREAIAELEREKEKLQQEAKLL-----QLKSEEMQTVQQ---EQLLQETQ 2475
Query: 371 RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRH 430
L ++ + +L+ +R F+ +A Q + +A + LR EQ+ Q+ +
Sbjct: 2476 ALQQSFLSEKDSLLQRER------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2529
Query: 431 YQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHL 490
+ E+A++ + + ++ +E + Q L+Q +EL + + L E L
Sbjct: 2530 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLR-EQL 2584
Query: 491 GPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKV 550
E + A SE+ Q +K TLP G D + E E + + RKV
Sbjct: 2585 QLLEEQHRAALAHSEEVTASQVAATK-----TLPNGRDALDGPAAEAEPEHSFDGLRRKV 2639
Query: 551 NA 552
+A
Sbjct: 2640 SA 2641
Score = 38.1 bits (87), Expect = 0.026
Identities = 47/194 (24%), Positives = 74/194 (38%), Gaps = 17/194 (8%)
Query: 306 EHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEE-- 363
E E R + ER RQ+ + + A+ + + KA+ +A E Q LQ LEE
Sbjct: 1470 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELR 1528
Query: 364 -QVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQK 422
Q +RL + R Q + ALE + +A+ L +R AE+
Sbjct: 1529 LQAEEAERRLRQAEVERA-----RQVQVALETAQRSAEAE--------LQSKRASFAEKT 1575
Query: 423 EQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQ 482
Q +HVA + + R Q + E + L + A LR Q +
Sbjct: 1576 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1635
Query: 483 ELLHSEHLGPSELE 496
E+ + L +E E
Sbjct: 1636 EVAQQKSLAQAEAE 1649
Score = 35.8 bits (81), Expect = 0.13
Identities = 41/160 (25%), Positives = 70/160 (43%), Gaps = 17/160 (10%)
Query: 312 RAKMDLEERRMRQINEVMR--EWAMADNQSKNLPKADRQALNEHFQSILQTLEEQV-SGE 368
+A+ + +E + R EV+R E A+ Q K + + Q L + ++ +Q Q + E
Sbjct: 1371 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1430
Query: 369 RQRLVETHATRVIAL---INDQRRAALEGFLAAL-------QADPPQAERVLLALRRYLR 418
R RL RV+ L +++R EG L AL +A QA+ LRR ++
Sbjct: 1431 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1490
Query: 419 AEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEE 458
E + +R + E A++ + LQ +EE
Sbjct: 1491 DESQRKRQAEVELASRVKAEAEAAREKQ----RALQALEE 1526
Score = 33.5 bits (75), Expect = 0.63
Identities = 47/204 (23%), Positives = 86/204 (42%), Gaps = 25/204 (12%)
Query: 311 LRAKMDLEERRMRQI--NEVMREWAMADNQSKNLPKADRQA----LNEHFQSILQTLEEQ 364
L+AK++ E RR+R+ E R+ +A ++ +A+ +A + + Q + QTL+++
Sbjct: 2000 LKAKVE-EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2058
Query: 365 VSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRA----- 419
S Q E A R A ++ R E A + +AER+ + +A
Sbjct: 2059 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2118
Query: 420 -------EQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPH 472
++ EQ R AA+ ++A + H ++ Q+L Q
Sbjct: 2119 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH------KKFAEQTLRQKAQVEQ 2172
Query: 473 LAQELRPQIQELLHSEHLGPSELE 496
LR Q++E H ++L EL+
Sbjct: 2173 ELTTLRLQLEETDHQKNLLDEELQ 2196
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 42.4 bits (98), Expect = 0.001
Identities = 58/242 (23%), Positives = 104/242 (42%), Gaps = 25/242 (10%)
Query: 312 RAKMDLEERRMRQ-INEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQ 370
R + D + R+R+ I E+ RE ++K L Q +E Q++ Q EQ+ E Q
Sbjct: 2465 RQQSDHDAERLREAIAELEREKEKLQQEAKLL-----QLKSEEMQTVQQ---EQLLQETQ 2516
Query: 371 RLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRH 430
L ++ + +L+ +R F+ +A Q + +A + LR EQ+ Q+ +
Sbjct: 2517 ALQQSFLSEKDSLLQRER------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2570
Query: 431 YQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHL 490
+ E+A++ + + ++ +E + Q L+Q +EL + + L E L
Sbjct: 2571 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQ----LEQQRRQQEELLAEENQRLR-EQL 2625
Query: 491 GPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKV 550
E + A SE+ Q +K TLP G D + E E + + RKV
Sbjct: 2626 QLLEEQHRAALAHSEEVTASQVAATK-----TLPNGRDALDGPAAEAEPEHSFDGLRRKV 2680
Query: 551 NA 552
+A
Sbjct: 2681 SA 2682
Score = 38.1 bits (87), Expect = 0.026
Identities = 47/194 (24%), Positives = 74/194 (38%), Gaps = 17/194 (8%)
Query: 306 EHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEE-- 363
E E R + ER RQ+ + + A+ + + KA+ +A E Q LQ LEE
Sbjct: 1511 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELR 1569
Query: 364 -QVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQK 422
Q +RL + R Q + ALE + +A+ L +R AE+
Sbjct: 1570 LQAEEAERRLRQAEVERA-----RQVQVALETAQRSAEAE--------LQSKRASFAEKT 1616
Query: 423 EQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQ 482
Q +HVA + + R Q + E + L + A LR Q +
Sbjct: 1617 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1676
Query: 483 ELLHSEHLGPSELE 496
E+ + L +E E
Sbjct: 1677 EVAQQKSLAQAEAE 1690
Score = 35.8 bits (81), Expect = 0.13
Identities = 41/160 (25%), Positives = 70/160 (43%), Gaps = 17/160 (10%)
Query: 312 RAKMDLEERRMRQINEVMR--EWAMADNQSKNLPKADRQALNEHFQSILQTLEEQV-SGE 368
+A+ + +E + R EV+R E A+ Q K + + Q L + ++ +Q Q + E
Sbjct: 1412 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1471
Query: 369 RQRLVETHATRVIAL---INDQRRAALEGFLAAL-------QADPPQAERVLLALRRYLR 418
R RL RV+ L +++R EG L AL +A QA+ LRR ++
Sbjct: 1472 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1531
Query: 419 AEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEE 458
E + +R + E A++ + LQ +EE
Sbjct: 1532 DESQRKRQAEVELASRVKAEAEAAREKQ----RALQALEE 1567
Score = 33.5 bits (75), Expect = 0.63
Identities = 47/204 (23%), Positives = 86/204 (42%), Gaps = 25/204 (12%)
Query: 311 LRAKMDLEERRMRQI--NEVMREWAMADNQSKNLPKADRQA----LNEHFQSILQTLEEQ 364
L+AK++ E RR+R+ E R+ +A ++ +A+ +A + + Q + QTL+++
Sbjct: 2041 LKAKVE-EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2099
Query: 365 VSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRA----- 419
S Q E A R A ++ R E A + +AER+ + +A
Sbjct: 2100 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2159
Query: 420 -------EQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPH 472
++ EQ R AA+ ++A + H ++ Q+L Q
Sbjct: 2160 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH------KKFAEQTLRQKAQVEQ 2213
Query: 473 LAQELRPQIQELLHSEHLGPSELE 496
LR Q++E H ++L EL+
Sbjct: 2214 ELTTLRLQLEETDHQKNLLDEELQ 2237
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 42.0 bits (97), Expect = 0.002
Identities = 73/327 (22%), Positives = 125/327 (38%), Gaps = 77/327 (23%)
Query: 254 DDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRA 313
D+ E +EEEEE VP ++V +PGE + FLR
Sbjct: 317 DETEYEYSGSEEEEEEVPEQEGEPSSIVN-----------------VPGESTLRRDFLRL 359
Query: 314 KMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLV 373
+ + +ER +E +R +Q L E + + Q+ ERQ+ +
Sbjct: 360 QQENKER-----SEALRR---------------QQLLQEQQLREQEEYKRQLLAERQKRI 399
Query: 374 ETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRY----LRAEQKEQRHTLR 429
E + L QRR A Q + Q R RR R +++E+R
Sbjct: 400 EQQKEQRRRLEEQQRRER----EARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAE 455
Query: 430 HYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEH 489
+ + E ++ + HL+V+++++ Q +L L RP Q HS+
Sbjct: 456 EEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAML-----LHDHRRPHPQ---HSQQ 507
Query: 490 LGPSELEAPAPG-GSSEDKGGLQPPD----------------SKDDTPMTLPKGSTEQDA 532
P + E P + E K +P D S+ D+P+ +GS +Q++
Sbjct: 508 PPPPQQERSKPSFHAPEPKAHYEPADRAREVPVRTTSRSPVLSRRDSPL---QGSGQQNS 564
Query: 533 ASPEKEKMNPLEQ---YERKVNASVPR 556
+ ++ + +E +ER V VPR
Sbjct: 565 QAGQRNSTSSIEPRLLWER-VEKLVPR 590
>gi|138175817 zinc finger protein 236 [Homo sapiens]
Length = 1845
Score = 41.2 bits (95), Expect = 0.003
Identities = 40/165 (24%), Positives = 74/165 (44%), Gaps = 23/165 (13%)
Query: 411 LALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQV-IE-ERVNQSLGLLD 468
L +++++ + E L+ +Q A++D Q Q T +QV IE + + Q+ ++
Sbjct: 754 LNCKKHMKTHRYELAQQLQQHQQAASIDDSTVDQQSMQASTQMQVEIESDELPQTAEVVA 813
Query: 469 QNPHLAQELRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGST 528
NP +L P Q ++ +E G + A P + ED G + P D P+ +G
Sbjct: 814 ANPEAMLDLEP--QHVVGTEEAGLGQQLADQPLEADED-GFVAPQD-----PL---RGHV 862
Query: 529 EQ-DAASPEKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAP 572
+Q + SP ++ P A +P+GF + Q+ + P
Sbjct: 863 DQFEEQSPAQQSFEP---------AGLPQGFTVTDTYHQQPQFPP 898
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 40.8 bits (94), Expect = 0.004
Identities = 56/219 (25%), Positives = 92/219 (42%), Gaps = 17/219 (7%)
Query: 300 MPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQ 359
+PGE + FLR ++ +ER +E +R + Q +N + RQ L E + I
Sbjct: 344 LPGESTLRRDFLRLQLANKER-----SEALRRQQLEQQQREN-EEHKRQLLAERQKRI-- 395
Query: 360 TLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPP--QAERVLLALRRYL 417
EEQ E++R +E R L Q R + ++ + +AE +RR L
Sbjct: 396 --EEQ--KEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQL 451
Query: 418 RAEQKEQRHTLRHYQHVAAVDPE-KAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQE 476
EQ++ + H A+ E K +Q+ Q + ++ ++ Q L H QE
Sbjct: 452 EEEQRQLEILQQQLLHEQALLLEYKRKQLEEQ--RQAERLQRQLKQERDYLVSLQHQRQE 509
Query: 477 LRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDS 515
RP ++ L+ G S E PA E++ L S
Sbjct: 510 QRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSS 548
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 40.8 bits (94), Expect = 0.004
Identities = 56/219 (25%), Positives = 92/219 (42%), Gaps = 17/219 (7%)
Query: 300 MPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQ 359
+PGE + FLR ++ +ER +E +R + Q +N + RQ L E + I
Sbjct: 344 LPGESTLRRDFLRLQLANKER-----SEALRRQQLEQQQREN-EEHKRQLLAERQKRI-- 395
Query: 360 TLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPP--QAERVLLALRRYL 417
EEQ E++R +E R L Q R + ++ + +AE +RR L
Sbjct: 396 --EEQ--KEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQL 451
Query: 418 RAEQKEQRHTLRHYQHVAAVDPE-KAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQE 476
EQ++ + H A+ E K +Q+ Q + ++ ++ Q L H QE
Sbjct: 452 EEEQRQLEILQQQLLHEQALLLEYKRKQLEEQ--RQAERLQRQLKQERDYLVSLQHQRQE 509
Query: 477 LRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDS 515
RP ++ L+ G S E PA E++ L S
Sbjct: 510 QRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSS 548
>gi|209862789 microtubule associated monoxygenase, calponin and LIM
domain containing 3 isoform 1 [Homo sapiens]
Length = 2002
Score = 40.4 bits (93), Expect = 0.005
Identities = 38/137 (27%), Positives = 52/137 (37%), Gaps = 11/137 (8%)
Query: 175 QEAQEACSSQGLILHGSGM-LLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPP 233
+E +E SS GL LHGS + GS F + PP +P P +P+T
Sbjct: 1417 EERRELSSSSGLGLHGSSSNMKTLGSQSFNTSDSAMLTPPSSPPPPPPPGEEPAT----- 1471
Query: 234 GSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDG 293
R + E E P P+ ++ PP+ E PP + V V P D
Sbjct: 1472 -LRRKLREAEPNASVVPPPLPATWMRPPR----EPAQPPREEVRKSFVESVEEIPFADDV 1526
Query: 294 VDIYFGMPGEISEHEGF 310
D Y + S E F
Sbjct: 1527 EDTYDDKTEDSSLQEKF 1543
>gi|32484977 angiomotin like 2 [Homo sapiens]
Length = 780
Score = 40.4 bits (93), Expect = 0.005
Identities = 53/205 (25%), Positives = 83/205 (40%), Gaps = 42/205 (20%)
Query: 308 EGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHF--QSILQTLEEQV 365
E +R KMD E RR++ N +RE + N+ + QA ++ + + Q+ E+Q
Sbjct: 373 EKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQ- 431
Query: 366 SGERQRLVETHATRVIALINDQRRAA--LEGFLAALQADPPQAERVLLALRRYLRAEQKE 423
+ Q +E + I DQRR A LE L Q +AE L + Y+ ++
Sbjct: 432 --QEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERL 489
Query: 424 QRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQE 483
Q+ L Q EK +Q+ ++ T L+ QEL+
Sbjct: 490 QQ-ALGQLQAAC----EKREQLELRLRTRLE--------------------QELKA---- 520
Query: 484 LLHSEHLGPSELEAPAPGGSSEDKG 508
L + +A APGGSS G
Sbjct: 521 ------LRAQQRQAGAPGGSSGSGG 539
>gi|33356148 formin-like 1 [Homo sapiens]
Length = 1100
Score = 40.0 bits (92), Expect = 0.007
Identities = 69/300 (23%), Positives = 114/300 (38%), Gaps = 44/300 (14%)
Query: 211 PPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETV 270
PPP P P G PS + PP + + E P P + PP
Sbjct: 542 PPPPPPLP-----GLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPP------ 590
Query: 271 PPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFL----RAKMDLEER-RMRQI 325
PPP T V P P P G G P + + L +AK ++ + RM +
Sbjct: 591 PPPPPGTDGPVPPPPPPPPPPPG-----GPPDALGRRDSELGPGVKAKKPIQTKFRMPLL 645
Query: 326 NEVMREWAMAD-------NQSKNLPKADRQALNEHFQ----------SILQTLEEQVSGE 368
N V + + N K L + D E F+ S L++ Q +
Sbjct: 646 NWVALKPSQITGTVFTELNDEKVLQELDMSDFEEQFKTKSQGPSLDLSALKSKAAQKAPS 705
Query: 369 RQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERV--LLALRRYLRAEQKEQRH 426
+ L+E + + +A+ + E A++A QA + L L R+L E +R
Sbjct: 706 KATLIEANRAKNLAITLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEY--ERS 763
Query: 427 TLRHYQHVAAVDPEKAQQMRFQV-HTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELL 485
+ ++ E +++ RF + + + + ER+ +L L P AQ L PQ+ ++
Sbjct: 764 LITRFEREQRPMEELSEEDRFMLCFSRIPRLPERMT-TLTFLGNFPDTAQLLMPQLNAII 822
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 39.7 bits (91), Expect = 0.009
Identities = 50/203 (24%), Positives = 87/203 (42%), Gaps = 30/203 (14%)
Query: 311 LRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGER- 369
L+ ++ EE RMR+ W A QS +AD + ++ LQ L E++ ++
Sbjct: 651 LQKAIEEEEARMREEESQRLSWLRAQVQSST--QADEDQIRAEQEASLQKLREELESQQK 708
Query: 370 --QRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHT 427
+ +E +++ + ++ A+ + AAL A E+ L LR L E+KE T
Sbjct: 709 AERASLEQKNRQMLEQLKEEIEASEKSEQAALNA---AKEKALQQLREQLEGERKEAVAT 765
Query: 428 L-----------------RHYQHVAAVD---PEKAQQMRFQVHTHLQVIEERVNQ-SLGL 466
L +H + V+++ E Q+ Q+ L +E RV+Q S +
Sbjct: 766 LEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHV 825
Query: 467 LDQNPHLAQELRPQIQELLHSEH 489
L+ LR + QE + EH
Sbjct: 826 AGYEHELSSLLREKRQE-VEGEH 847
Score = 38.9 bits (89), Expect = 0.015
Identities = 39/161 (24%), Positives = 66/161 (40%), Gaps = 12/161 (7%)
Query: 264 EEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMR 323
EEEE + S L+ + + D I + + L ++ E +
Sbjct: 656 EEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLE 715
Query: 324 QINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIAL 383
Q N M E + ++ K+++ ALN + LQ L EQ+ GER+ V T
Sbjct: 716 QKNRQMLEQLKEEIEASE--KSEQAALNAAKEKALQQLREQLEGERKEAVAT-------- 765
Query: 384 INDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQ 424
+ + A LE ++L+A E V ++ A+QKE+
Sbjct: 766 LEKEHSAELERLCSSLEA--KHREVVSSLQKKIQEAQQKEE 804
Score = 29.6 bits (65), Expect = 9.1
Identities = 38/158 (24%), Positives = 64/158 (40%), Gaps = 23/158 (14%)
Query: 352 EH-FQSILQTLEEQVSGERQR----LVETHATRVIALINDQ-------RRAALEGFLAAL 399
EH S+L+ ++V GE +R + E H +V+A +Q +RA L G L
Sbjct: 829 EHELSSLLREKRQEVEGEHERRLDKMKEEHQ-QVMAKAREQYEAEERKQRAELLGHLTG- 886
Query: 400 QADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEER 459
+ ER+ A R L ++EQ L + K Q + + T + ++ R
Sbjct: 887 -----ELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKAR 941
Query: 460 VNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEA 497
L LL+ A+ + Q+ ++ L E A
Sbjct: 942 ----LALLEVQEETARREKQQLLDVQRQVALKSEEATA 975
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 39.3 bits (90), Expect = 0.011
Identities = 53/203 (26%), Positives = 87/203 (42%), Gaps = 17/203 (8%)
Query: 300 MPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQ 359
+PGE + FLR ++ +ER +E +R + Q +N + RQ L E + I
Sbjct: 344 LPGESTLRRDFLRLQLANKER-----SEALRRQQLEQQQREN-EEHKRQLLAERQKRI-- 395
Query: 360 TLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPP--QAERVLLALRRYL 417
EEQ E++R +E R L Q R + ++ + +AE +RR L
Sbjct: 396 --EEQ--KEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQL 451
Query: 418 RAEQKEQRHTLRHYQHVAAVDPE-KAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQE 476
EQ++ + H A+ E K +Q+ Q + ++ ++ Q L H QE
Sbjct: 452 EEEQRQLEILQQQLLHEQALLLEYKRKQLEEQ--RQAERLQRQLKQERDYLVSLQHQRQE 509
Query: 477 LRPQIQELLHSEHLGPSELEAPA 499
RP ++ L+ G S E PA
Sbjct: 510 QRPVEKKPLYHYKEGMSPSEKPA 532
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 39.3 bits (90), Expect = 0.011
Identities = 53/203 (26%), Positives = 87/203 (42%), Gaps = 17/203 (8%)
Query: 300 MPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQ 359
+PGE + FLR ++ +ER +E +R + Q +N + RQ L E + I
Sbjct: 344 LPGESTLRRDFLRLQLANKER-----SEALRRQQLEQQQREN-EEHKRQLLAERQKRI-- 395
Query: 360 TLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPP--QAERVLLALRRYL 417
EEQ E++R +E R L Q R + ++ + +AE +RR L
Sbjct: 396 --EEQ--KEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQL 451
Query: 418 RAEQKEQRHTLRHYQHVAAVDPE-KAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQE 476
EQ++ + H A+ E K +Q+ Q + ++ ++ Q L H QE
Sbjct: 452 EEEQRQLEILQQQLLHEQALLLEYKRKQLEEQ--RQAERLQRQLKQERDYLVSLQHQRQE 509
Query: 477 LRPQIQELLHSEHLGPSELEAPA 499
RP ++ L+ G S E PA
Sbjct: 510 QRPVEKKPLYHYKEGMSPSEKPA 532
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,620,708
Number of Sequences: 37866
Number of extensions: 1852271
Number of successful extensions: 11596
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 64
Number of HSP's successfully gapped in prelim test: 315
Number of HSP's that attempted gapping in prelim test: 10476
Number of HSP's gapped (non-prelim): 1210
length of query: 650
length of database: 18,247,518
effective HSP length: 109
effective length of query: 541
effective length of database: 14,120,124
effective search space: 7638987084
effective search space used: 7638987084
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.