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Search of human proteins with 13375848
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13375848 SMC6 protein [Homo sapiens]
(1091 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|214010216 SMC6 protein [Homo sapiens] 2149 0.0
gi|13375848 SMC6 protein [Homo sapiens] 2149 0.0
gi|155722985 SMC5 protein [Homo sapiens] 144 5e-34
gi|118498356 kinectin 1 isoform a [Homo sapiens] 102 3e-21
gi|33620775 kinectin 1 isoform a [Homo sapiens] 102 3e-21
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 100 1e-20
gi|118498362 kinectin 1 isoform b [Homo sapiens] 97 8e-20
gi|156104908 myosin heavy chain 6 [Homo sapiens] 96 2e-19
gi|118498368 kinectin 1 isoform c [Homo sapiens] 95 4e-19
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 94 9e-19
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 89 2e-17
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 89 2e-17
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 89 2e-17
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 89 2e-17
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 87 9e-17
gi|4885399 structural maintenance of chromosomes 3 [Homo sapiens] 87 1e-16
gi|50658065 SMC4 structural maintenance of chromosomes 4-like 1 ... 86 1e-16
gi|50658063 SMC4 structural maintenance of chromosomes 4-like 1 ... 86 1e-16
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 86 2e-16
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 82 2e-15
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 82 3e-15
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 81 5e-15
gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens] 80 8e-15
gi|82880656 coiled-coil domain containing 46 isoform a [Homo sap... 79 3e-14
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 77 9e-14
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 77 9e-14
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 77 1e-13
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 77 1e-13
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 77 1e-13
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 76 2e-13
>gi|214010216 SMC6 protein [Homo sapiens]
Length = 1091
Score = 2149 bits (5569), Expect = 0.0
Identities = 1091/1091 (100%), Positives = 1091/1091 (100%)
Query: 1 MAKRKEENFSSPKNAKRPRQEELEDFDKDGDEDECKGTTLTAAEVGIIESIHLKNFMCHS 60
MAKRKEENFSSPKNAKRPRQEELEDFDKDGDEDECKGTTLTAAEVGIIESIHLKNFMCHS
Sbjct: 1 MAKRKEENFSSPKNAKRPRQEELEDFDKDGDEDECKGTTLTAAEVGIIESIHLKNFMCHS 60
Query: 61 MLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGRAVATNRGSSLKGFVKDGQNSADIS 120
MLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGRAVATNRGSSLKGFVKDGQNSADIS
Sbjct: 61 MLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGRAVATNRGSSLKGFVKDGQNSADIS 120
Query: 121 ITLRNRGDDAFKASVYGNSILIQQHISIDGSRSYKLKSATGSVVSTRKEELIAILDHFNI 180
ITLRNRGDDAFKASVYGNSILIQQHISIDGSRSYKLKSATGSVVSTRKEELIAILDHFNI
Sbjct: 121 ITLRNRGDDAFKASVYGNSILIQQHISIDGSRSYKLKSATGSVVSTRKEELIAILDHFNI 180
Query: 181 QVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQG 240
QVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQG
Sbjct: 181 QVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQG 240
Query: 241 EERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIG 300
EERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIG
Sbjct: 241 EERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIG 300
Query: 301 EDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAY 360
EDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAY
Sbjct: 301 EDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAY 360
Query: 361 NEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAF 420
NEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAF
Sbjct: 361 NEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAF 420
Query: 421 QNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRF 480
QNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRF
Sbjct: 421 QNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRF 480
Query: 481 GPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHA 540
GPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHA
Sbjct: 481 GPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHA 540
Query: 541 DERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVAN 600
DERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVAN
Sbjct: 541 DERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVAN 600
Query: 601 SLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFL 660
SLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFL
Sbjct: 601 SLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFL 660
Query: 661 SRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKN 720
SRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKN
Sbjct: 661 SRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKN 720
Query: 721 ISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKY 780
ISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKY
Sbjct: 721 ISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKY 780
Query: 781 DAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKE 840
DAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKE
Sbjct: 781 DAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKE 840
Query: 841 KELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARE 900
KELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARE
Sbjct: 841 KELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARE 900
Query: 901 TYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNF 960
TYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNF
Sbjct: 901 TYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNF 960
Query: 961 DHKNETLSISVQPGEGNKAAFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVY 1020
DHKNETLSISVQPGEGNKAAFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVY
Sbjct: 961 DHKNETLSISVQPGEGNKAAFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVY 1020
Query: 1021 MDMVNRRIAMDLILKMADSQRFRQFILLTPQSMSSLPSSKLIRILRMSDPERGQTTLPFR 1080
MDMVNRRIAMDLILKMADSQRFRQFILLTPQSMSSLPSSKLIRILRMSDPERGQTTLPFR
Sbjct: 1021 MDMVNRRIAMDLILKMADSQRFRQFILLTPQSMSSLPSSKLIRILRMSDPERGQTTLPFR 1080
Query: 1081 PVTQEEDDDQR 1091
PVTQEEDDDQR
Sbjct: 1081 PVTQEEDDDQR 1091
>gi|13375848 SMC6 protein [Homo sapiens]
Length = 1091
Score = 2149 bits (5569), Expect = 0.0
Identities = 1091/1091 (100%), Positives = 1091/1091 (100%)
Query: 1 MAKRKEENFSSPKNAKRPRQEELEDFDKDGDEDECKGTTLTAAEVGIIESIHLKNFMCHS 60
MAKRKEENFSSPKNAKRPRQEELEDFDKDGDEDECKGTTLTAAEVGIIESIHLKNFMCHS
Sbjct: 1 MAKRKEENFSSPKNAKRPRQEELEDFDKDGDEDECKGTTLTAAEVGIIESIHLKNFMCHS 60
Query: 61 MLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGRAVATNRGSSLKGFVKDGQNSADIS 120
MLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGRAVATNRGSSLKGFVKDGQNSADIS
Sbjct: 61 MLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGRAVATNRGSSLKGFVKDGQNSADIS 120
Query: 121 ITLRNRGDDAFKASVYGNSILIQQHISIDGSRSYKLKSATGSVVSTRKEELIAILDHFNI 180
ITLRNRGDDAFKASVYGNSILIQQHISIDGSRSYKLKSATGSVVSTRKEELIAILDHFNI
Sbjct: 121 ITLRNRGDDAFKASVYGNSILIQQHISIDGSRSYKLKSATGSVVSTRKEELIAILDHFNI 180
Query: 181 QVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQG 240
QVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQG
Sbjct: 181 QVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQG 240
Query: 241 EERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIG 300
EERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIG
Sbjct: 241 EERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIG 300
Query: 301 EDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAY 360
EDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAY
Sbjct: 301 EDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAY 360
Query: 361 NEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAF 420
NEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAF
Sbjct: 361 NEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAF 420
Query: 421 QNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRF 480
QNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRF
Sbjct: 421 QNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRF 480
Query: 481 GPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHA 540
GPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHA
Sbjct: 481 GPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHA 540
Query: 541 DERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVAN 600
DERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVAN
Sbjct: 541 DERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVAN 600
Query: 601 SLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFL 660
SLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFL
Sbjct: 601 SLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFL 660
Query: 661 SRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKN 720
SRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKN
Sbjct: 661 SRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKN 720
Query: 721 ISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKY 780
ISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKY
Sbjct: 721 ISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKY 780
Query: 781 DAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKE 840
DAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKE
Sbjct: 781 DAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKE 840
Query: 841 KELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARE 900
KELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARE
Sbjct: 841 KELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARE 900
Query: 901 TYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNF 960
TYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNF
Sbjct: 901 TYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNF 960
Query: 961 DHKNETLSISVQPGEGNKAAFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVY 1020
DHKNETLSISVQPGEGNKAAFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVY
Sbjct: 961 DHKNETLSISVQPGEGNKAAFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVY 1020
Query: 1021 MDMVNRRIAMDLILKMADSQRFRQFILLTPQSMSSLPSSKLIRILRMSDPERGQTTLPFR 1080
MDMVNRRIAMDLILKMADSQRFRQFILLTPQSMSSLPSSKLIRILRMSDPERGQTTLPFR
Sbjct: 1021 MDMVNRRIAMDLILKMADSQRFRQFILLTPQSMSSLPSSKLIRILRMSDPERGQTTLPFR 1080
Query: 1081 PVTQEEDDDQR 1091
PVTQEEDDDQR
Sbjct: 1081 PVTQEEDDDQR 1091
>gi|155722985 SMC5 protein [Homo sapiens]
Length = 1101
Score = 144 bits (363), Expect = 5e-34
Identities = 243/1119 (21%), Positives = 467/1119 (41%), Gaps = 199/1119 (17%)
Query: 46 GIIESIHLKNFMCHSMLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGRAVATNRGSS 105
G I I ++NF+ + + G ++N +VG NG+GKS+++ A+ +GL G+ R
Sbjct: 51 GSIVRISMENFLTYDIC-EVSPGPHLNMIVGANGTGKSSIVCAICLGLAGKPAFMGRADK 109
Query: 106 LKGFVKDGQNSADISITLRNRGDDAFKASVYGNSILIQQHISIDGSRSY---KLKSATGS 162
+ FVK G + + I L F+AS +++I + I + ++S+ KS T
Sbjct: 110 VGFFVKRGCSRGMVEIEL-------FRAS---GNLVITREIDVAKNQSFWFINKKSTTQK 159
Query: 163 VVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQ-SKNEGDKYKFFMKATQLE---- 217
+V EE +A L NIQV N L Q+ +F + SK E ++AT+
Sbjct: 160 IV----EEKVAAL---NIQVGNLCQFLPQDKVGEFAKLSKIE------LLEATEKSIGPP 206
Query: 218 QMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERF-QSIAGLSTMKTNL---ES 273
+M + + + +E+ K Q+ + TE ++ V++ ER+ Q + K +L E
Sbjct: 207 EMHKYHCELKNLREKEK-QLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEM 265
Query: 274 LKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQV----RLNEAEQKYKDIQ 329
L+ + W + ++ + +K+ DR RK++E Q+ R+ E E + +++
Sbjct: 266 LEAKRPWVEYENVRQEY----EEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLE 321
Query: 330 DKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIE 389
++++ + + + +C K DV+ +K K IE
Sbjct: 322 ARIKEKATDIKEASQKCKQ-KQDVIERKD---------------------------KHIE 353
Query: 390 ELKKSTDQSLEPERLERQKKISWLKERVKAFQNQ----ENSVN--QEIEQFQQAIEKDKE 443
EL+++ + E L+RQ++I ++ ++ QN+ EN N +I+ + + ++
Sbjct: 354 ELQQALIVK-QNEELDRQRRIGNTRKMIEDLQNELKTTENCENLQPQIDAITNDLRRIQD 412
Query: 444 EHGKIKREELDVKHALSYNQRQLKELKD----------SKTDRLK-RFGPNVPALLEAID 492
E + E +D + +++ K + D K D+L+ RF A+L +
Sbjct: 413 EKALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRN 472
Query: 493 DAYRQGHFTYKPVGPLGACIHLRDPELALAIESCL-KGLLQAYCCHNHADERVL------ 545
+ + F + P+ I+++D + A IE+ + L+A+ + D V
Sbjct: 473 N---RDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRD 529
Query: 546 --QALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLI 603
+ + P +S S NE+ F + L L V + L
Sbjct: 530 NKKLRVNAVIAPKSSYADKAPSRSLNELKQY--------GFFSYLRELFDAPDPVMSYLC 581
Query: 604 DMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYS----SENTRPK- 658
I V + + R Q+ ++ +TA+ V +YS S NT K
Sbjct: 582 CQYHIHEVPVGTEKTRERIERVIQE--TRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKV 639
Query: 659 --FLSRDVDSE-ISDLENEVENKTAQILNLQQHLSALEKDIKHNE-----------ELLK 704
FL+ VD E LE +++ ++ + L AL + KH E ELL+
Sbjct: 640 AQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLE 699
Query: 705 RCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKE 764
R + ++L+ KI + ++ +E D LE+E E K+ K+ E ++++ K
Sbjct: 700 R-KTKKRQLEQKISSKLGSLKLMEQ-------DTCNLEEE--ERKASTKIKEINVQKAKL 749
Query: 765 NMEHLKSLKIEAE---NKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEK 821
E +KI K D I +SE + L+ + A S++
Sbjct: 750 VTELTNLIKICTSLHIQKVDLILQNTTVISE-KNKLESDYMAASSQL-----------RL 797
Query: 822 QKEHLDTLNKKKRELDMKEKELEEKMSQARQIC--------PERIEVE---------KSA 864
++H L++ ++ L K KEL M +ARQ+C P+ + + S
Sbjct: 798 TEQHFIELDENRQRLLQKCKEL---MKRARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSL 854
Query: 865 SILDKEINRLRQKIQAEHASHGDR------------EEIMRQYQEARETYLDLDSKVRTL 912
++ +++ +I A R +E ++ +E + +L K L
Sbjct: 855 PMVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKKVEL 914
Query: 913 KKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNFDHKNET------ 966
++ + + ++ E ++ L + F N S G+++ +NE
Sbjct: 915 DQYRENISQVKERWLNPLKE----LVEKINEKFSNFFSSMQCAGEVDLHTENEEDYDKYG 970
Query: 967 LSISVQPGEGNKAAFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNR 1026
+ I V+ + SGGERS ST+ ++++L + PFR +DE + MD +N
Sbjct: 971 IRIRVKFRSSTQLHELTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDEINQGMDPINE 1030
Query: 1027 RIAMDLILKMADSQRFRQFILLTPQSMSSLPSSKLIRIL 1065
R ++++ A + Q+ +TP+ + +LP S+ + +L
Sbjct: 1031 RRVFEMVVNTACKENTSQYFFITPKLLQNLPYSEKMTVL 1069
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 102 bits (253), Expect = 3e-21
Identities = 162/873 (18%), Positives = 350/873 (40%), Gaps = 125/873 (14%)
Query: 162 SVVSTRKEELIAILDHFNIQVDNPVSVL---TQEMSKQFLQSKNEGDKYKFFMK------ 212
+VV TR ++ I L+ + N + V TQ+M +F Q + + + +K
Sbjct: 370 NVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGIL 429
Query: 213 ---------------ATQLEQMKEDYSYIM-ETKERT----KEQIHQ--GEERLTELKRQ 250
+ +L ++++DY+ ++ E E+T +E++ + E+ T+LK Q
Sbjct: 430 RDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQ 489
Query: 251 CVEKEERFQSIAGLSTMKTNLESLKHEMAW--------AVVNEIEKQLNAIRDNIKIGED 302
E E R++ + +T +HE A A NE++ + + D + +
Sbjct: 490 LQEAERRWEEVQSYIRKRT----AEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQ 545
Query: 303 RAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNE 362
RL + ME +Q R+N+ E +QD I E+ A + + + A+ A
Sbjct: 546 LEQRLMQLMESEQKRVNKEESLQMQVQD----ILEQNEALKAQIQQFHSQIAAQTSASVL 601
Query: 363 AEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQN 422
AE L+ + K +K+ ++ L + L ++ + + + K ++++A N
Sbjct: 602 AEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAE--VQKLQALAN 659
Query: 423 QENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGP 482
++ + E+E+ QQ++ + KI+ E ++H +S + K L D K
Sbjct: 660 EQAAAAHELEKMQQSVYVKDD---KIRLLEEQLQHEISNKMEEFKILNDQN----KALKS 712
Query: 483 NVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADE 542
V L + + + V + CI +D +L E GL+Q E
Sbjct: 713 EVQKLQTLVSEQPNK-----DVVEQMEKCIQEKDEKLKTVEELLETGLIQV-----ATKE 762
Query: 543 RVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSL 602
L A+ S E+ D++ + F +++ L+ V+
Sbjct: 763 EELNAIRTE------------NSSLTKEVQDLKAKQNDQVSFASLVEELK---KVIHEKD 807
Query: 603 IDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSR 662
++ +E +L + VA +K ++ ++ A +++ K
Sbjct: 808 GKIKSVEELLEAELLKVA----NKEKTVQDLKQEIKALKEEI-------GNVQLEKAQQL 856
Query: 663 DVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRK--- 719
+ S++ +L+N ++ K Q+ ++ L EKD+ + + L+ Q + LK +++
Sbjct: 857 SITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQ 916
Query: 720 -NISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAEN 778
N+ E EE LE +E ++++K +E +++++ ++ L + ++
Sbjct: 917 HNLKEASSASQFEE--------LEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQD 968
Query: 779 KYDAIKFKINQLSE------LADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKK 832
+ K +I QL + + P +EL SE + + G + + K+ ++ KK
Sbjct: 969 ENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKK 1028
Query: 833 KRELDMKEKELEEKMSQARQICPERI-----EVEKSASILDKEINRLRQKI--QAEHASH 885
+L K E E ++ ++ +++ E ++ ++ E + +K+ + S+
Sbjct: 1029 NNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSN 1088
Query: 886 GDREEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYF 945
E + +++ + + S +K ++EH+ K + L L C+ Y
Sbjct: 1089 LSYGEWLHGFEKKAKECMAGTSGSEEVK--------VLEHKLKEADEMHTLLQLECEKYK 1140
Query: 946 DNLLSQRAYCGKMNFDHKNETLSISVQPGEGNK 978
L K+ + E V+ E +K
Sbjct: 1141 SVLAETEGILQKLQRSVEQEENKWKVKVDESHK 1173
Score = 70.9 bits (172), Expect = 6e-12
Identities = 154/770 (20%), Positives = 320/770 (41%), Gaps = 142/770 (18%)
Query: 214 TQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKT---- 269
T + E+ ++ K++ QI Q E+ L + + KEE + I ++ +
Sbjct: 596 TSASVLAEELHKVIAEKDK---QIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQ 652
Query: 270 NLESLKHEMAWAVVNEIEKQLNAIR---DNIKIGEDRAAR-LDRKMEE------------ 313
L++L +E A A +E+EK ++ D I++ E++ + KMEE
Sbjct: 653 KLQALANEQA-AAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALK 711
Query: 314 ---QQVRLNEAEQKYKDIQDKLEKISEETNAR---APECMALKADVVAKKRAYNEAEVLY 367
Q+++ +EQ KD+ +++EK +E + + E + VA K A
Sbjct: 712 SEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTE 771
Query: 368 NRSLN----EYKALKKDDEQLCKRIEELKK----------STDQSLEPERLE---RQKKI 410
N SL + KA + D +EELKK S ++ LE E L+ ++K +
Sbjct: 772 NSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTV 831
Query: 411 SWLKERVKAFQN----------QENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALS 460
LK+ +KA + Q+ S+ ++++ Q ++ +E+ +K + + L+
Sbjct: 832 QDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLA 891
Query: 461 YNQRQLKELKDSKTDRLKRFGPNVPA--LLEAIDDA-YRQGHFTYKP----VGPLGACIH 513
+ L++L++ + + LK V L EA + + + K + L A +
Sbjct: 892 NTGKWLQDLQE-ENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLK 950
Query: 514 LRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPI-----IVSEFR 568
R+ +L+ + LLQ N + ++ L ++ Y +S PP ++SE
Sbjct: 951 ERESDLSSKTQ-----LLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISERE 1005
Query: 569 NEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVARAVMQSQK 628
EI + + E+D+ + +++ R L KN A+ ++K
Sbjct: 1006 KEISGLWN---------------ELDS--LKDAVEHQRKKNNDLREKNWEAMEALASTEK 1048
Query: 629 PPKN-CREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLE--NEVENKTAQIL-- 683
++ + QV A + E + F V S +S E + E K + +
Sbjct: 1049 MLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAG 1108
Query: 684 -NLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLE 742
+ + + LE +K +E+ QL ++ K + + +++L+ +SV
Sbjct: 1109 TSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQ-----RSV------ 1157
Query: 743 DEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSELADPLKDELN 802
E +ENK K+K+ E H + ++ ++S +E + + ++ +
Sbjct: 1158 -EQEENKWKVKVDESH-----KTIKQMQSSFTSSEQELERLRSE---------------- 1195
Query: 803 LADSEVDNQKRGKRHYE---EKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIE 859
+ +++N +R + H E EK + T + REL EL++K+ + E +
Sbjct: 1196 --NKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYS---EAVR 1250
Query: 860 VEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARETYLDLDSKV 909
+ ++L ++N K++ E +R+++ +A+++ + SK+
Sbjct: 1251 QNEELNLLKAQLNETLTKLRTE---QNERQKVAGDLHKAQQSLELIQSKI 1297
Score = 57.0 bits (136), Expect = 1e-07
Identities = 137/749 (18%), Positives = 286/749 (38%), Gaps = 121/749 (16%)
Query: 268 KTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKD 327
K L +L H++ E +K L A++++ +DR +L ++M ++ R N + KD
Sbjct: 324 KGELTTLIHQL-----QEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKD 378
Query: 328 -----------IQDKLEKISEETNARAPECMALKADV------------VAKKRAYNEAE 364
Q+K+ +ET + ++ + + + N
Sbjct: 379 RIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTN 438
Query: 365 VLYNRSLNEYKALKKDDEQLCKRIEE----LKKSTDQSLEPERLERQKKISWLKERVKAF 420
L ++ E L++D +L + E L++ Q E+ Q K+ L+E + +
Sbjct: 439 QLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQ-LQEAERRW 497
Query: 421 QNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYN--------QRQLKELKDS 472
+ ++ + + + +A ++D + K E+ H+ + +++L +L +S
Sbjct: 498 EEVQSYIRKRTAE-HEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMES 556
Query: 473 KTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQ 532
+ R+ + +L + D Q + + I + LA E
Sbjct: 557 EQKRVNK----EESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEE-------- 604
Query: 533 AYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALE 592
H E+ Q L + R + E E+ D+++ L AL
Sbjct: 605 ---LHKVIAEKDKQIKQTEDSL-ASERDRLTSKE--EELKDIQNMNFLLKAEVQKLQALA 658
Query: 593 IDNAVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSS 652
+ A A+ L M + + +K++ + Q Q N E F DQ + S
Sbjct: 659 NEQAAAAHELEKM---QQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQ---NKALKS 712
Query: 653 ENTRPKFL-----SRDV-----------DSEISDLENEVENKTAQILNLQQHLSALE--- 693
E + + L ++DV D ++ +E +E Q+ ++ L+A+
Sbjct: 713 EVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTEN 772
Query: 694 -------KDIKHNEELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQ 746
+D+K + +ELK I + +I+ +E + E + + +A E Q
Sbjct: 773 SSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQ 832
Query: 747 ENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSE----LADPLKDELN 802
+ K ++K ++E + + S+ + + + +K K Q++ L + KD N
Sbjct: 833 DLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLAN 892
Query: 803 ----LADSEVDNQKRGKRHYEEKQKEHLD-------------TLNKKKRELDMKEKELEE 845
L D + +N+ K H +E + +L L +K+ EL E L+E
Sbjct: 893 TGKWLQDLQEENESL-KAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKE 951
Query: 846 KMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARETYLDL 905
+ S +V+ + +I +L+Q+ + +S EE+++ E + L
Sbjct: 952 RESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGL 1011
Query: 906 DSKVRTLKKFIKLLGEIMEHRFKTYQQFR 934
+++ +LK + +EH+ K R
Sbjct: 1012 WNELDSLK-------DAVEHQRKKNNDLR 1033
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 102 bits (253), Expect = 3e-21
Identities = 162/873 (18%), Positives = 350/873 (40%), Gaps = 125/873 (14%)
Query: 162 SVVSTRKEELIAILDHFNIQVDNPVSVL---TQEMSKQFLQSKNEGDKYKFFMK------ 212
+VV TR ++ I L+ + N + V TQ+M +F Q + + + +K
Sbjct: 370 NVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGIL 429
Query: 213 ---------------ATQLEQMKEDYSYIM-ETKERT----KEQIHQ--GEERLTELKRQ 250
+ +L ++++DY+ ++ E E+T +E++ + E+ T+LK Q
Sbjct: 430 RDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQ 489
Query: 251 CVEKEERFQSIAGLSTMKTNLESLKHEMAW--------AVVNEIEKQLNAIRDNIKIGED 302
E E R++ + +T +HE A A NE++ + + D + +
Sbjct: 490 LQEAERRWEEVQSYIRKRT----AEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQ 545
Query: 303 RAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNE 362
RL + ME +Q R+N+ E +QD I E+ A + + + A+ A
Sbjct: 546 LEQRLMQLMESEQKRVNKEESLQMQVQD----ILEQNEALKAQIQQFHSQIAAQTSASVL 601
Query: 363 AEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQN 422
AE L+ + K +K+ ++ L + L ++ + + + K ++++A N
Sbjct: 602 AEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAE--VQKLQALAN 659
Query: 423 QENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGP 482
++ + E+E+ QQ++ + KI+ E ++H +S + K L D K
Sbjct: 660 EQAAAAHELEKMQQSVYVKDD---KIRLLEEQLQHEISNKMEEFKILNDQN----KALKS 712
Query: 483 NVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADE 542
V L + + + V + CI +D +L E GL+Q E
Sbjct: 713 EVQKLQTLVSEQPNK-----DVVEQMEKCIQEKDEKLKTVEELLETGLIQV-----ATKE 762
Query: 543 RVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSL 602
L A+ S E+ D++ + F +++ L+ V+
Sbjct: 763 EELNAIRTE------------NSSLTKEVQDLKAKQNDQVSFASLVEELK---KVIHEKD 807
Query: 603 IDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSR 662
++ +E +L + VA +K ++ ++ A +++ K
Sbjct: 808 GKIKSVEELLEAELLKVA----NKEKTVQDLKQEIKALKEEI-------GNVQLEKAQQL 856
Query: 663 DVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRK--- 719
+ S++ +L+N ++ K Q+ ++ L EKD+ + + L+ Q + LK +++
Sbjct: 857 SITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQ 916
Query: 720 -NISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAEN 778
N+ E EE LE +E ++++K +E +++++ ++ L + ++
Sbjct: 917 HNLKEASSASQFEE--------LEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQD 968
Query: 779 KYDAIKFKINQLSE------LADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKK 832
+ K +I QL + + P +EL SE + + G + + K+ ++ KK
Sbjct: 969 ENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKK 1028
Query: 833 KRELDMKEKELEEKMSQARQICPERI-----EVEKSASILDKEINRLRQKI--QAEHASH 885
+L K E E ++ ++ +++ E ++ ++ E + +K+ + S+
Sbjct: 1029 NNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSN 1088
Query: 886 GDREEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYF 945
E + +++ + + S +K ++EH+ K + L L C+ Y
Sbjct: 1089 LSYGEWLHGFEKKAKECMAGTSGSEEVK--------VLEHKLKEADEMHTLLQLECEKYK 1140
Query: 946 DNLLSQRAYCGKMNFDHKNETLSISVQPGEGNK 978
L K+ + E V+ E +K
Sbjct: 1141 SVLAETEGILQKLQRSVEQEENKWKVKVDESHK 1173
Score = 70.9 bits (172), Expect = 6e-12
Identities = 154/770 (20%), Positives = 320/770 (41%), Gaps = 142/770 (18%)
Query: 214 TQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKT---- 269
T + E+ ++ K++ QI Q E+ L + + KEE + I ++ +
Sbjct: 596 TSASVLAEELHKVIAEKDK---QIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQ 652
Query: 270 NLESLKHEMAWAVVNEIEKQLNAIR---DNIKIGEDRAAR-LDRKMEE------------ 313
L++L +E A A +E+EK ++ D I++ E++ + KMEE
Sbjct: 653 KLQALANEQA-AAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALK 711
Query: 314 ---QQVRLNEAEQKYKDIQDKLEKISEETNAR---APECMALKADVVAKKRAYNEAEVLY 367
Q+++ +EQ KD+ +++EK +E + + E + VA K A
Sbjct: 712 SEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTE 771
Query: 368 NRSLN----EYKALKKDDEQLCKRIEELKK----------STDQSLEPERLE---RQKKI 410
N SL + KA + D +EELKK S ++ LE E L+ ++K +
Sbjct: 772 NSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTV 831
Query: 411 SWLKERVKAFQN----------QENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALS 460
LK+ +KA + Q+ S+ ++++ Q ++ +E+ +K + + L+
Sbjct: 832 QDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLA 891
Query: 461 YNQRQLKELKDSKTDRLKRFGPNVPA--LLEAIDDA-YRQGHFTYKP----VGPLGACIH 513
+ L++L++ + + LK V L EA + + + K + L A +
Sbjct: 892 NTGKWLQDLQE-ENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLK 950
Query: 514 LRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPI-----IVSEFR 568
R+ +L+ + LLQ N + ++ L ++ Y +S PP ++SE
Sbjct: 951 ERESDLSSKTQ-----LLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISERE 1005
Query: 569 NEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVARAVMQSQK 628
EI + + E+D+ + +++ R L KN A+ ++K
Sbjct: 1006 KEISGLWN---------------ELDS--LKDAVEHQRKKNNDLREKNWEAMEALASTEK 1048
Query: 629 PPKN-CREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLE--NEVENKTAQIL-- 683
++ + QV A + E + F V S +S E + E K + +
Sbjct: 1049 MLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAG 1108
Query: 684 -NLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLE 742
+ + + LE +K +E+ QL ++ K + + +++L+ +SV
Sbjct: 1109 TSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQ-----RSV------ 1157
Query: 743 DEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSELADPLKDELN 802
E +ENK K+K+ E H + ++ ++S +E + + ++ +
Sbjct: 1158 -EQEENKWKVKVDESH-----KTIKQMQSSFTSSEQELERLRSE---------------- 1195
Query: 803 LADSEVDNQKRGKRHYE---EKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIE 859
+ +++N +R + H E EK + T + REL EL++K+ + E +
Sbjct: 1196 --NKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYS---EAVR 1250
Query: 860 VEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARETYLDLDSKV 909
+ ++L ++N K++ E +R+++ +A+++ + SK+
Sbjct: 1251 QNEELNLLKAQLNETLTKLRTE---QNERQKVAGDLHKAQQSLELIQSKI 1297
Score = 57.0 bits (136), Expect = 1e-07
Identities = 137/749 (18%), Positives = 286/749 (38%), Gaps = 121/749 (16%)
Query: 268 KTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKD 327
K L +L H++ E +K L A++++ +DR +L ++M ++ R N + KD
Sbjct: 324 KGELTTLIHQL-----QEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKD 378
Query: 328 -----------IQDKLEKISEETNARAPECMALKADV------------VAKKRAYNEAE 364
Q+K+ +ET + ++ + + + N
Sbjct: 379 RIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTN 438
Query: 365 VLYNRSLNEYKALKKDDEQLCKRIEE----LKKSTDQSLEPERLERQKKISWLKERVKAF 420
L ++ E L++D +L + E L++ Q E+ Q K+ L+E + +
Sbjct: 439 QLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQ-LQEAERRW 497
Query: 421 QNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYN--------QRQLKELKDS 472
+ ++ + + + +A ++D + K E+ H+ + +++L +L +S
Sbjct: 498 EEVQSYIRKRTAE-HEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMES 556
Query: 473 KTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQ 532
+ R+ + +L + D Q + + I + LA E
Sbjct: 557 EQKRVNK----EESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEE-------- 604
Query: 533 AYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALE 592
H E+ Q L + R + E E+ D+++ L AL
Sbjct: 605 ---LHKVIAEKDKQIKQTEDSL-ASERDRLTSKE--EELKDIQNMNFLLKAEVQKLQALA 658
Query: 593 IDNAVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSS 652
+ A A+ L M + + +K++ + Q Q N E F DQ + S
Sbjct: 659 NEQAAAAHELEKM---QQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQ---NKALKS 712
Query: 653 ENTRPKFL-----SRDV-----------DSEISDLENEVENKTAQILNLQQHLSALE--- 693
E + + L ++DV D ++ +E +E Q+ ++ L+A+
Sbjct: 713 EVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTEN 772
Query: 694 -------KDIKHNEELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQ 746
+D+K + +ELK I + +I+ +E + E + + +A E Q
Sbjct: 773 SSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQ 832
Query: 747 ENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSE----LADPLKDELN 802
+ K ++K ++E + + S+ + + + +K K Q++ L + KD N
Sbjct: 833 DLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLAN 892
Query: 803 ----LADSEVDNQKRGKRHYEEKQKEHLD-------------TLNKKKRELDMKEKELEE 845
L D + +N+ K H +E + +L L +K+ EL E L+E
Sbjct: 893 TGKWLQDLQEENESL-KAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKE 951
Query: 846 KMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARETYLDL 905
+ S +V+ + +I +L+Q+ + +S EE+++ E + L
Sbjct: 952 RESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGL 1011
Query: 906 DSKVRTLKKFIKLLGEIMEHRFKTYQQFR 934
+++ +LK + +EH+ K R
Sbjct: 1012 WNELDSLK-------DAVEHQRKKNNDLR 1033
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 99.8 bits (247), Expect = 1e-20
Identities = 138/679 (20%), Positives = 284/679 (41%), Gaps = 122/679 (17%)
Query: 212 KATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEK-EERFQSIAGLSTMKTN 270
KA + + S + + + + + Q E L E K++ ++ +E +++ ++ ++
Sbjct: 1354 KAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSS 1413
Query: 271 LESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQD 330
LE KH + NEIE + +++ AA LD+K L E +QKY++ Q
Sbjct: 1414 LEKTKHRLQ----NEIED----LMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQS 1465
Query: 331 KLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEE 390
+LE +E + + E L K AY E SL + K++++ L + I +
Sbjct: 1466 ELESSQKEARSLSTELFKL-------KNAYEE-------SLEHLETFKRENKNLQEEISD 1511
Query: 391 LKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEHGKIKR 450
L + S K I L++ K + ++ + +E+ + ++E E GKI R
Sbjct: 1512 LTEQLGSS--------GKTIHELEKVRKQLEAEKMELQSALEEAEASLE---HEEGKILR 1560
Query: 451 EELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGA 510
+L+ + +R+L E KD + ++ KR V L+ DA
Sbjct: 1561 AQLEFNQIKAEIERKLAE-KDEEMEQAKRNHLRVVDSLQTSLDA---------------- 1603
Query: 511 CIHLRDPELALAIESCLKG-LLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRN 569
R AL ++ ++G L + +HA+ +A + V ++
Sbjct: 1604 --ETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQ-------------VKSLQS 1648
Query: 570 EIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNN-------SVARA 622
+ D T +++D+AV AN D++ ++ +NN +
Sbjct: 1649 LLKD---------------TQIQLDDAVRAND--DLKENIAIVERRNNLLQAELEELRAV 1691
Query: 623 VMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQI 682
V Q+++ K + ++V + S+NT + +D+++S L+ EVE +
Sbjct: 1692 VEQTERSRKLAEQELIETSERV---QLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQEC 1748
Query: 683 LNLQQHLSALEKDIKHNEELLKRCQ---LHYKELKMKIRKNISEIRELENIEEHQSVDIA 739
N ++ D E LK+ Q H + +K + + I +++ ++E + + +
Sbjct: 1749 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQ--HRLDEAEQIALK 1806
Query: 740 TLEDEAQENKSKMKMVEEHME-QQKENMEHLKSLKIEAENKYDAIKFKINQLSELADPLK 798
+ + Q+ +++++ +E +E +QK N E +K ++ ++E + + ++ + + L+
Sbjct: 1807 GGKKQLQKLEARVRELENELEAEQKRNAESVKGMR-KSERRIKELTYQTEEDRKNLLRLQ 1865
Query: 799 DELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERI 858
D ++ +V KR EE+ +L K + ELD
Sbjct: 1866 DLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELD--------------------- 1904
Query: 859 EVEKSASILDKEINRLRQK 877
E E+ A I + ++N+LR K
Sbjct: 1905 EAEERADIAESQVNKLRAK 1923
Score = 85.1 bits (209), Expect = 3e-16
Identities = 144/753 (19%), Positives = 305/753 (40%), Gaps = 91/753 (12%)
Query: 226 IMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNE 285
++++ ER KE EE T LK + +EK E A ++ + SL E N+
Sbjct: 839 LLKSAEREKEMASMKEE-FTRLK-EALEKSE-----ARRKELEEKMVSLLQEK-----ND 886
Query: 286 IEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPE 345
++ Q+ A +DN+ E+R +L + + + ++ E ++ +D ++ +++ + E
Sbjct: 887 LQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE 946
Query: 346 CMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKD----DEQLCKRIEE---LKKSTDQS 398
C LK D+ + + E + + N+ K L ++ DE + K +E L+++ Q+
Sbjct: 947 CSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA 1006
Query: 399 LEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHA 458
L+ + E K + K +VK + Q+++ + ++E++K+ ++R + ++
Sbjct: 1007 LDDLQAEEDKVNTLTKAKVK--------LEQQVDDLEGSLEQEKKVRMDLERAKRKLEGD 1058
Query: 459 LSYNQRQLKELKDSK---TDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLR 515
L Q + +L++ K +RLK+ + AL I+D G K + L A +
Sbjct: 1059 LKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQA--RIE 1116
Query: 516 DPELALAIESCLKGLLQAYCCHNHAD-ERVLQALMKRFYLPGTSRPPII------VSEFR 568
+ E L E + ++ +D R L+ + +R G + I +EF+
Sbjct: 1117 ELEEELEAERTARAKVEKL----RSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQ 1172
Query: 569 NEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVARAVMQSQK 628
D+ H L D+ ID ++ V + ++
Sbjct: 1173 KMRRDLEEATLQHEATAAALRKKHADSVAELGEQID--NLQRVKQKLEKEKSEFKLELDD 1230
Query: 629 PPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQILNLQQH 688
N + A + R + + + + ++DL T+Q LQ
Sbjct: 1231 VTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDL-------TSQRAKLQTE 1283
Query: 689 LSALEKDIKHNEEL---LKRCQLHY----KELKMKIRKNISEIRELENIEEHQSVDIATL 741
L + + E L L R +L Y ++LK ++ + + L + + D L
Sbjct: 1284 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343
Query: 742 EDEAQEN---KSKMKMV---------------EEHMEQQKENMEHLKSLKI----EAENK 779
++ +E K++++ V E Q+ E +E K EAE
Sbjct: 1344 REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEA 1403
Query: 780 YDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMK 839
+A+ K + L + L++E+ +V+ ++KQ+ L + K++ +
Sbjct: 1404 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES 1463
Query: 840 EKELEEKMSQARQICPERIEV----EKSASILD---KEINRLRQKIQAEHASHGDREEIM 892
+ ELE +AR + E ++ E+S L+ +E L+++I G + +
Sbjct: 1464 QSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTI 1523
Query: 893 RQYQEARETYLDLDSKVRTLKKFIKLLGEIMEH 925
+ ++ R+ L+++ L+ ++ +EH
Sbjct: 1524 HELEKVRK---QLEAEKMELQSALEEAEASLEH 1553
Score = 68.9 bits (167), Expect = 2e-11
Identities = 166/870 (19%), Positives = 341/870 (39%), Gaps = 125/870 (14%)
Query: 155 KLKSATGSVVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKA- 213
K K AT + V EE+ A LD ++ L + + + E DK KA
Sbjct: 966 KEKHATENKVKNLTEEM-AGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAK 1024
Query: 214 TQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNL-E 272
+LEQ +D +E +++ + + + + +L + E SI L K L E
Sbjct: 1025 VKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE------SIMDLENDKQQLDE 1078
Query: 273 SLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYK------ 326
LK + + +LNA+ I+ + ++L +K++E Q R+ E E++ +
Sbjct: 1079 RLKKK---------DFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTAR 1129
Query: 327 --------DIQDKLEKISEE-------TNARAPECMALKADVVAKKRAYNEAEVLYNRSL 371
D+ +LE+ISE T+ + +A+ +R EA + + +
Sbjct: 1130 AKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATA 1189
Query: 372 NEYKALKKDD-EQLCKRIEELKKSTDQSLEPER----LERQKKISWLKERVKA------- 419
+ D +L ++I+ L++ Q LE E+ LE S +++ +KA
Sbjct: 1190 AALRKKHADSVAELGEQIDNLQR-VKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKM 1248
Query: 420 ---FQNQENSVNQEIEQFQQAIEKDKEEHGKIKRE------ELDVKHAL---------SY 461
++Q N + E+ Q+++ + K++ E +LD K AL +Y
Sbjct: 1249 CRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTY 1308
Query: 462 NQRQLKELKDSKTDRLKRFGPNVPALLEAIDDA---YRQGHFTYKPVGPLGACIHLRDPE 518
Q QL++LK + +K AL A D Q + L + + E
Sbjct: 1309 TQ-QLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSE 1367
Query: 519 LALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRA 578
+A +Q A +++ Q L + V+ + + +HR
Sbjct: 1368 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQE------AEEAVEAVNAKCSSLEKTKHRL 1421
Query: 579 AYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFT 638
+ ++ +E NA A R + +L + + + K R T
Sbjct: 1422 --QNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLST 1479
Query: 639 ADGDQVFAGRYYSSENTRP----KFLSRDVDSEISDLENEV--ENKT------------A 680
++F + E+ K ++++ EISDL ++ KT A
Sbjct: 1480 ----ELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEA 1535
Query: 681 QILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISE-IRELENIEEHQSVDIA 739
+ + LQ L E ++H E + R QL + ++K +I + ++E E+E + + +
Sbjct: 1536 EKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVD 1595
Query: 740 TLE---DEAQENKSKMKMVEEHMEQQKENME----HLKSLKIEAENKYDAIKFKINQLSE 792
+L+ D ++++ V++ ME ME H + EA+ + +++ + L +
Sbjct: 1596 SLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQ---SLLKD 1652
Query: 793 LADPLKDELNLADSEVDN---QKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQ 849
L D + D +N +R + + +E + + +R + E+EL E +
Sbjct: 1653 TQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSER 1712
Query: 850 ARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQ-------YQEARETY 902
+ + + + +D ++++L+ +++ + EE ++ E +
Sbjct: 1713 VQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKE 1772
Query: 903 LDLDSKVRTLKKFIKLLGEIMEHRFKTYQQ 932
D + + +KK ++ + ++HR +Q
Sbjct: 1773 QDTSAHLERMKKNMEQTIKDLQHRLDEAEQ 1802
Score = 53.5 bits (127), Expect = 1e-06
Identities = 152/805 (18%), Positives = 321/805 (39%), Gaps = 146/805 (18%)
Query: 166 TRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSY 225
TR +E + + +++ + L QE + LQ + E D L +E
Sbjct: 857 TRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDN---------LADAEERCDQ 907
Query: 226 IMETKERTKEQIHQGEERLT---ELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAV 282
+++ K + + ++ + ERL E+ + K+ + + S +K +++ L+ +A
Sbjct: 908 LIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDEC--SELKRDIDDLELTLA--- 962
Query: 283 VNEIEKQLNAIRDNIKIGEDRAARLDR---KMEEQQVRLNEAEQK-YKDIQDKLEKISEE 338
++EK+ +A + +K + A LD K+ +++ L EA Q+ D+Q + +K++
Sbjct: 963 --KVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTL 1020
Query: 339 TNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQS 398
T A+ V ++ ++ E SL + K ++ D E+ +++E K T +S
Sbjct: 1021 TKAK-----------VKLEQQVDDLE----GSLEQEKKVRMDLERAKRKLEGDLKLTQES 1065
Query: 399 LEP---------ERLERQK-KISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEHGKI 448
+ ERL+++ +++ L R++ Q + + +++++ Q IE+ +EE
Sbjct: 1066 IMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAE 1125
Query: 449 KREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPL 508
+ V+ S R+L+E+ ++RL+ G +E + R+ F
Sbjct: 1126 RTARAKVEKLRSDLSRELEEI----SERLEEAGGATSVQIEM--NKKREAEFQKM----- 1174
Query: 509 GACIHLRDPELALAIESCLKGLLQAYCCHNHAD------------ERVLQALMKRFYLPG 556
RD E A L+ HAD +RV Q L K
Sbjct: 1175 -----RRDLEEATLQHEATAAALR----KKHADSVAELGEQIDNLQRVKQKLEKE----- 1220
Query: 557 TSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDM------RGIET 610
SEF+ E+ DV + + + + +L D + ET
Sbjct: 1221 -------KSEFKLELDDVTSNMEQ-------IIKAKANLEKMCRTLEDQMNEHRSKAEET 1266
Query: 611 VLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISD 670
+ + + RA +Q++ N + D + + + T + L D+ ++ +
Sbjct: 1267 QRSVNDLTSQRAKLQTE----NGELSRQLDEKEALISQLTRGKLTYTQQL-EDLKRQLEE 1321
Query: 671 LENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIRELENI 730
E + +N A L +H L ++ E K EL+ + K SE+ +
Sbjct: 1322 -EVKAKNALAHALQSARHDCDLLREQYEEETEAK------AELQRVLSKANSEVAQWRTK 1374
Query: 731 EEHQSVD-IATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQ 789
E ++ LE+ ++ +++ EE +E L+ K +N+ + + + +
Sbjct: 1375 YETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVER 1434
Query: 790 LSELADPL--------------KDELNLADSEVDNQKRGKRHYE----------EKQKEH 825
+ A L K + + SE+++ ++ R E+ EH
Sbjct: 1435 SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH 1494
Query: 826 LDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASH 885
L+T ++ + L + +L E++ + + E+EK L+ E L+ ++ AS
Sbjct: 1495 LETFKRENKNLQEEISDLTEQLGSSGKTIH---ELEKVRKQLEAEKMELQSALEEAEASL 1551
Query: 886 GDRE-EIMRQYQEARETYLDLDSKV 909
E +I+R E + +++ K+
Sbjct: 1552 EHEEGKILRAQLEFNQIKAEIERKL 1576
>gi|118498362 kinectin 1 isoform b [Homo sapiens]
Length = 1306
Score = 97.1 bits (240), Expect = 8e-20
Identities = 160/873 (18%), Positives = 342/873 (39%), Gaps = 148/873 (16%)
Query: 162 SVVSTRKEELIAILDHFNIQVDNPVSVL---TQEMSKQFLQSKNEGDKYKFFMK------ 212
+VV TR ++ I L+ + N + V TQ+M +F Q + + + +K
Sbjct: 370 NVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGIL 429
Query: 213 ---------------ATQLEQMKEDYSYIM-ETKERT----KEQIHQ--GEERLTELKRQ 250
+ +L ++++DY+ ++ E E+T +E++ + E+ T+LK Q
Sbjct: 430 RDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQ 489
Query: 251 CVEKEERFQSIAGLSTMKTNLESLKHEMAW--------AVVNEIEKQLNAIRDNIKIGED 302
E E R++ + +T +HE A A NE++ + + D + +
Sbjct: 490 LQEAERRWEEVQSYIRKRT----AEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQ 545
Query: 303 RAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNE 362
RL + ME +Q R+N+ E +QD I E+ A + + + A+ A
Sbjct: 546 LEQRLMQLMESEQKRVNKEESLQMQVQD----ILEQNEALKAQIQQFHSQIAAQTSASVL 601
Query: 363 AEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQN 422
AE L+ + K +K+ ++ L + L ++ + + + K ++++A N
Sbjct: 602 AEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAE--VQKLQALAN 659
Query: 423 QENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGP 482
++ + E+E+ QQ++ + KI+ E ++H +S + K L D K
Sbjct: 660 EQAAAAHELEKMQQSVYVKDD---KIRLLEEQLQHEISNKMEEFKILNDQN----KALKS 712
Query: 483 NVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADE 542
V L + + + V + CI +D +L E GL+Q E
Sbjct: 713 EVQKLQTLVSEQPNK-----DVVEQMEKCIQEKDEKLKTVEELLETGLIQV-----ATKE 762
Query: 543 RVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSL 602
L A+ S E+ D++ + F +++ L+ V+
Sbjct: 763 EELNAIRTE------------NSSLTKEVQDLKAKQNDQVSFASLVEELK---KVIHEKD 807
Query: 603 IDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSR 662
++ +E +L + VA + K +
Sbjct: 808 GKIKSVEELLEAELLKVA----------------------------------NKEKTVQL 833
Query: 663 DVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRK--- 719
+ S++ +L+N ++ K Q+ ++ L EKD+ + + L+ Q + LK +++
Sbjct: 834 SITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQ 893
Query: 720 -NISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAEN 778
N+ E EE LE +E ++++K +E +++++ ++ L + ++
Sbjct: 894 HNLKEASSASQFEE--------LEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQD 945
Query: 779 KYDAIKFKINQLSE------LADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKK 832
+ K +I QL + + P +EL SE + + G + + K+ ++ KK
Sbjct: 946 ENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKK 1005
Query: 833 KRELDMKEKELEEKMSQARQICPERI-----EVEKSASILDKEINRLRQKI--QAEHASH 885
+L K E E ++ ++ +++ E ++ ++ E + +K+ + S+
Sbjct: 1006 NNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSN 1065
Query: 886 GDREEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYF 945
E + +++ + + S +K ++EH+ K + L L C+ Y
Sbjct: 1066 LSYGEWLHGFEKKAKECMAGTSGSEEVK--------VLEHKLKEADEMHTLLQLECEKYK 1117
Query: 946 DNLLSQRAYCGKMNFDHKNETLSISVQPGEGNK 978
L K+ + E V+ E +K
Sbjct: 1118 SVLAETEGILQKLQRSVEQEENKWKVKVDESHK 1150
Score = 58.2 bits (139), Expect = 4e-08
Identities = 140/739 (18%), Positives = 300/739 (40%), Gaps = 116/739 (15%)
Query: 214 TQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKT---- 269
T + E+ ++ K++ QI Q E+ L + + KEE + I ++ +
Sbjct: 596 TSASVLAEELHKVIAEKDK---QIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQ 652
Query: 270 NLESLKHEMAWAVVNEIEKQLNAIR---DNIKIGEDRAAR-LDRKMEE------------ 313
L++L +E A A +E+EK ++ D I++ E++ + KMEE
Sbjct: 653 KLQALANEQA-AAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALK 711
Query: 314 ---QQVRLNEAEQKYKDIQDKLEKISEETNAR---APECMALKADVVAKKRAYNEAEVLY 367
Q+++ +EQ KD+ +++EK +E + + E + VA K A
Sbjct: 712 SEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTE 771
Query: 368 NRSLN----EYKALKKDDEQLCKRIEELKK----------STDQSLEPERLE---RQK-- 408
N SL + KA + D +EELKK S ++ LE E L+ ++K
Sbjct: 772 NSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTV 831
Query: 409 ------KISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYN 462
K+ L+ +K + Q N++ +E+ EKD GK ++ + +L +
Sbjct: 832 QLSITSKVQELQNLLKGKEEQMNTMKAVLEEK----EKDLANTGKWLQDLQEENESLKAH 887
Query: 463 QRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALA 522
+++ + + +F L E ++ R L A + R+ +L+
Sbjct: 888 VQEVAQHNLKEASSASQFEELEIVLKEKENELKR-----------LEAMLKERESDLSSK 936
Query: 523 IESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPI-----IVSEFRNEIYDVRHR 577
+ LLQ N + ++ L ++ Y +S PP ++SE EI + +
Sbjct: 937 TQ-----LLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWN- 990
Query: 578 AAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKN-CREA 636
E+D+ + +++ R L KN A+ ++K ++ +
Sbjct: 991 --------------ELDS--LKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKT 1034
Query: 637 FTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLE--NEVENKTAQIL---NLQQHLSA 691
QV A + E + F V S +S E + E K + + + + +
Sbjct: 1035 SKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKV 1094
Query: 692 LEKDIKHNEELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSK 751
LE +K +E+ QL ++ K + + +++L+ E + DE+ +
Sbjct: 1095 LEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKT--- 1151
Query: 752 MKMVEEHMEQQKENMEHLKSLKIEAEN---KYDAIKFKINQLSELADPLKDELNLADSEV 808
+K ++ ++ +E L+S + EN + + ++ ++ + E+ +++
Sbjct: 1152 IKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQL 1211
Query: 809 DNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKEL-----EEKMSQARQICPERIEVEKS 863
+ R + ++++ L+K ++ L++ + ++ + + + + PE EK
Sbjct: 1212 NETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKE 1271
Query: 864 --ASILDKEINRLRQKIQA 880
+ L++ + +L+Q +QA
Sbjct: 1272 TMSVSLNQTVTQLQQLLQA 1290
Score = 55.1 bits (131), Expect = 4e-07
Identities = 136/730 (18%), Positives = 280/730 (38%), Gaps = 106/730 (14%)
Query: 268 KTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKD 327
K L +L H++ E +K L A++++ +DR +L ++M ++ R N + KD
Sbjct: 324 KGELTTLIHQL-----QEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKD 378
Query: 328 -----------IQDKLEKISEETNARAPECMALKADV------------VAKKRAYNEAE 364
Q+K+ +ET + ++ + + + N
Sbjct: 379 RIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTN 438
Query: 365 VLYNRSLNEYKALKKDDEQLCKRIEE----LKKSTDQSLEPERLERQKKISWLKERVKAF 420
L ++ E L++D +L + E L++ Q E+ Q K+ L+E + +
Sbjct: 439 QLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQ-LQEAERRW 497
Query: 421 QNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYN--------QRQLKELKDS 472
+ ++ + + + +A ++D + K E+ H+ + +++L +L +S
Sbjct: 498 EEVQSYIRKRTAE-HEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMES 556
Query: 473 KTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQ 532
+ R+ + +L + D Q + + I + LA E
Sbjct: 557 EQKRVNK----EESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEE-------- 604
Query: 533 AYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALE 592
H E+ Q L + R + E E+ D+++ L AL
Sbjct: 605 ---LHKVIAEKDKQIKQTEDSL-ASERDRLTSKE--EELKDIQNMNFLLKAEVQKLQALA 658
Query: 593 IDNAVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSS 652
+ A A+ L M + + +K++ + Q Q N E F DQ + S
Sbjct: 659 NEQAAAAHELEKM---QQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQ---NKALKS 712
Query: 653 ENTRPKFL-----SRDV-----------DSEISDLENEVENKTAQILNLQQHLSALE--- 693
E + + L ++DV D ++ +E +E Q+ ++ L+A+
Sbjct: 713 EVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTEN 772
Query: 694 -------KDIKHNEELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQ 746
+D+K + +ELK I + +I+ +E + E + + +A E Q
Sbjct: 773 SSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQ 832
Query: 747 EN-KSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSELADPLKDELNLAD 805
+ SK++ ++ ++ ++E M +K++ E E + L E + LK A
Sbjct: 833 LSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLK-----AH 887
Query: 806 SEVDNQKRGKRHYEEKQKEHLD-TLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSA 864
+ Q K Q E L+ L +K+ EL E L+E+ S +V+
Sbjct: 888 VQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDEN 947
Query: 865 SILDKEINRLRQKIQAEHASHGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIME 924
+ +I +L+Q+ + +S EE+++ E + L +++ +LK + +E
Sbjct: 948 KLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLK-------DAVE 1000
Query: 925 HRFKTYQQFR 934
H+ K R
Sbjct: 1001 HQRKKNNDLR 1010
Score = 42.7 bits (99), Expect = 0.002
Identities = 69/360 (19%), Positives = 155/360 (43%), Gaps = 49/360 (13%)
Query: 138 NSILIQQHISIDGSRSYKLKSA-----TGSV-VSTRKEELIAI----------LDHFNIQ 181
N +++Q + KLK+ TG + V+T++EEL AI + +
Sbjct: 726 NKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK 785
Query: 182 VDNPVSV--LTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKE--QI 237
++ VS L +E+ K + + + ++A L+ ++ + + + +E +
Sbjct: 786 QNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNL 845
Query: 238 HQGEERLTELKRQCVEKEERFQSIAG--LSTMKTNLESLKHEMAWAVVNEIEK-----QL 290
+G+E + +E++E+ + G L ++ ESLK + + +++ Q
Sbjct: 846 LKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQF 905
Query: 291 NAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQD-------KLEKISEETNARA 343
+ +K E+ RL+ ++E++ L+ Q +D+QD ++E++ ++ +A
Sbjct: 906 EELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQA 965
Query: 344 PECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPER 403
+ + + +E E + NE +LK E K+ +L++ +++E
Sbjct: 966 SSFPPHEELL----KVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEA-- 1019
Query: 404 LERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQ 463
L K Q++ N ++E +Q +A+E + +E K ++ V LSY +
Sbjct: 1020 ---------LASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGE 1070
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 95.5 bits (236), Expect = 2e-19
Identities = 133/672 (19%), Positives = 287/672 (42%), Gaps = 101/672 (15%)
Query: 212 KATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEK-EERFQSIAGLSTMKTN 270
KA + + S + + + + + Q E L E K++ ++ ++ +++ ++ ++
Sbjct: 1356 KAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSS 1415
Query: 271 LESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQD 330
LE KH + NEIE + +++ AA LD+K L E +QKY++ Q
Sbjct: 1416 LEKTKHRLQ----NEIED----LMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQS 1467
Query: 331 KLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEE 390
+LE +E + + E LK AY E SL + K++++ L + I +
Sbjct: 1468 ELESSQKEARSLSTELFKLK-------NAYEE-------SLEHLETFKRENKNLQEEISD 1513
Query: 391 LKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEHGKIKR 450
L + E K + L++ K + ++ + +E+ + ++E E GKI R
Sbjct: 1514 LTEQLG--------EGGKNVHELEKVRKQLEVEKLELQSALEEAEASLE---HEEGKILR 1562
Query: 451 EELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGA 510
+L+ + +R+L E KD + ++ KR V L+ DA
Sbjct: 1563 AQLEFNQIKAEIERKLAE-KDEEMEQAKRNHQRVVDSLQTSLDA---------------- 1605
Query: 511 CIHLRDPELALAIESCLKGLLQAYCCH-NHADERVLQALMKRFYLPGTSRPPIIVSEFRN 569
R L ++ ++G L +HA+ +A + V ++
Sbjct: 1606 --ETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQ-------------VKSLQS 1650
Query: 570 EIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVA------RAV 623
+ D T +++D+AV AN D++ ++ +NN + RAV
Sbjct: 1651 LLKD---------------TQIQLDDAVRAND--DLKENIAIVERRNNLLQAELEELRAV 1693
Query: 624 M-QSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQI 682
+ Q+++ K + ++V + S+NT + ++S+++ L++EVE +
Sbjct: 1694 VEQTERSRKLAEQELIETSERV---QLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQEC 1750
Query: 683 LNLQQHLSALEKDIKHNEELLKRCQ---LHYKELKMKIRKNISEIRELENIEEHQSVDIA 739
N ++ D E LK+ Q H + +K + + I +++ ++E + + +
Sbjct: 1751 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQH--RLDEAEQIALK 1808
Query: 740 TLEDEAQENKSKMKMVEEHME-QQKENMEHLKSLKIEAENKYDAIKFKINQLSELADPLK 798
+ + Q+ +++++ +E +E +QK N E +K ++ ++E + + ++ + + L+
Sbjct: 1809 GGKKQLQKLEARVRELEGELEAEQKRNAESVKGMR-KSERRIKELTYQTEEDKKNLLRLQ 1867
Query: 799 DELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERI 858
D ++ +V KR EE+ +L K + ELD E+ + SQ ++ +
Sbjct: 1868 DLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSR 1927
Query: 859 EVEKSASILDKE 870
++ + D+E
Sbjct: 1928 DIGAKQKMHDEE 1939
Score = 77.4 bits (189), Expect = 7e-14
Identities = 144/795 (18%), Positives = 318/795 (40%), Gaps = 130/795 (16%)
Query: 206 KYKFFMKATQLEQ----MKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSI 261
K K +K+ + E+ MKE++ I ET E+++ + + EE++ L ++
Sbjct: 837 KIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQE----------- 885
Query: 262 AGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEA 321
N+++ Q+ A +DN+ E+R +L + + + ++ E
Sbjct: 886 ---------------------KNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEM 924
Query: 322 EQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKD- 380
++ +D ++ +++ + EC LK D+ + + E + + N+ K L ++
Sbjct: 925 NERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEM 984
Query: 381 ---DEQLCKRIEE---LKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQF 434
DE + K +E L+++ Q+L+ ++E K S K +VK + Q+++
Sbjct: 985 AGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVK--------LEQQVDDL 1036
Query: 435 QQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSK---TDRLKRFGPNVPALLEAI 491
+ ++E++K+ ++R + ++ L Q + +L++ K ++LK+ ++ I
Sbjct: 1037 EGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKI 1096
Query: 492 DDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKR 551
+D + LAL ++ LK ++ ++ L +
Sbjct: 1097 ED----------------------EQVLALQLQKKLK-----------ENQARIEELEEE 1123
Query: 552 FYLPGTSRPPI--IVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIE 609
T+R + + S+ E+ ++ R +V +E++ A R +E
Sbjct: 1124 LEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSV--QIEMNKKREAEFQKMRRDLE 1181
Query: 610 TVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEIS 669
L ++ + A A+ K ++ G+Q+ + + + K + E+
Sbjct: 1182 EATL-QHEATAAALR------KKHADSVAELGEQIDNLQRVKQKLEKEK---SEFKLELD 1231
Query: 670 DLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIRELEN 729
D+ + +E NL++ LE L+ Q + + K +E EL
Sbjct: 1232 DVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELAR 1291
Query: 730 IEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQ 789
E + I+ L +M+ ++ +E++ + L A + D ++ + +
Sbjct: 1292 QLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEE 1351
Query: 790 LSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQ 849
+E L+ L+ A+SEV + + YE + + L + K++L + ++ EE +
Sbjct: 1352 ETEAKAELQRVLSKANSEV---AQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEA 1408
Query: 850 ARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARETYLDLDSKV 909
C S L+K +RL+ +I E++M + + LD K
Sbjct: 1409 VNAKC----------SSLEKTKHRLQNEI----------EDLMVDVERSNAAAAALDKKQ 1448
Query: 910 RTLKKFI---KLLGEIMEHRFKTYQQFRRCLT---LRCKLYFDNLLSQRAYCGKMNFDHK 963
R K + K E + ++ Q+ R L+ + K ++ L + N + +
Sbjct: 1449 RNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQ 1508
Query: 964 NETLSISVQPGEGNK 978
E ++ Q GEG K
Sbjct: 1509 EEISDLTEQLGEGGK 1523
Score = 67.4 bits (163), Expect = 7e-11
Identities = 165/872 (18%), Positives = 350/872 (40%), Gaps = 129/872 (14%)
Query: 155 KLKSATGSVVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKAT 214
K K AT + V EE+ + D ++ LT+E K+ LQ ++ +A
Sbjct: 968 KEKHATENKVKNLTEEMAGL--------DEIIAKLTKE--KKALQEAHQ--------QAL 1009
Query: 215 QLEQMKED-YSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAG-LSTMKTNLE 272
Q++ED + + ++K + ++Q+ E L + K+ ++ E + + G L + ++
Sbjct: 1010 DDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIM 1069
Query: 273 SLKHEMAWAVVNEIEKQLNAIRDNIKIGEDR--AARLDRKMEEQQVRLNEAEQKYK---- 326
L+++ +K+ + + N KI +++ A +L +K++E Q R+ E E++ +
Sbjct: 1070 DLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERT 1129
Query: 327 ----------DIQDKLEKISEE-------TNARAPECMALKADVVAKKRAYNEAEVLYNR 369
D+ +LE+ISE T+ + +A+ +R EA + +
Sbjct: 1130 ARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEA 1189
Query: 370 SLNEYKALKKDD-EQLCKRIEELKKSTDQSLEPER----LERQKKISWLKERVKA----- 419
+ + D +L ++I+ L++ Q LE E+ LE S +++ +KA
Sbjct: 1190 TAAALRKKHADSVAELGEQIDNLQR-VKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLE 1248
Query: 420 -----FQNQENSVNQEIEQFQQAIEKDKEEHGKIKRE------ELDVKHAL--------- 459
++Q N ++E+ Q+++ + K++ E +L+ K AL
Sbjct: 1249 KVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKL 1308
Query: 460 SYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDA---YRQGHFTYKPVGPLGACIHLRD 516
SY Q Q+++LK + K AL A D Q + L + +
Sbjct: 1309 SYTQ-QMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKAN 1367
Query: 517 PELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRH 576
E+A +Q A +++ Q L V+ + + +H
Sbjct: 1368 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQD------AEEAVEAVNAKCSSLEKTKH 1421
Query: 577 RAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREA 636
R + ++ +E NA A R + +L + + + K R
Sbjct: 1422 RL--QNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL 1479
Query: 637 FTADGDQVFAGRYYSSENTRP----KFLSRDVDSEISDLE----------NEVENKTAQI 682
T ++F + E+ K ++++ EISDL +E+E Q+
Sbjct: 1480 ST----ELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQL 1535
Query: 683 ----LNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISE-IRELENIE-EHQSV 736
L LQ L E ++H E + R QL + ++K +I + ++E E+E + HQ V
Sbjct: 1536 EVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRV 1595
Query: 737 --DIATLEDEAQENKSKMKMVEEHMEQQKENME----HLKSLKIEAENKYDAIKFKINQL 790
+ T D +++++ V++ ME ME H + EA+ + +++ + L
Sbjct: 1596 VDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQ---SLL 1652
Query: 791 SELADPLKDELNLADSEVDN---QKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKM 847
+ L D + D +N +R + + +E + + +R + E+EL E
Sbjct: 1653 KDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETS 1712
Query: 848 SQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQ-------YQEARE 900
+ + + + + ++ ++ +L+ +++ + EE ++ E +
Sbjct: 1713 ERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELK 1772
Query: 901 TYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQ 932
D + + +KK ++ + ++HR +Q
Sbjct: 1773 KEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQ 1804
>gi|118498368 kinectin 1 isoform c [Homo sapiens]
Length = 1300
Score = 94.7 bits (234), Expect = 4e-19
Identities = 158/866 (18%), Positives = 341/866 (39%), Gaps = 140/866 (16%)
Query: 162 SVVSTRKEELIAILDHFNIQVDNPVSVL---TQEMSKQFLQSKNEGDKYKFFMK------ 212
+VV TR ++ I L+ + N + V TQ+M +F Q + + + +K
Sbjct: 370 NVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGIL 429
Query: 213 ---------------ATQLEQMKEDYSYIM-ETKERT----KEQIHQ--GEERLTELKRQ 250
+ +L ++++DY+ ++ E E+T +E++ + E+ T+LK Q
Sbjct: 430 RDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQ 489
Query: 251 CVEKEERFQSIAGLSTMKTNLESLKHEMAW--------AVVNEIEKQLNAIRDNIKIGED 302
E E R++ + +T +HE A A NE++ + + D + +
Sbjct: 490 LQEAERRWEEVQSYIRKRT----AEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQ 545
Query: 303 RAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNE 362
RL + ME +Q R+N+ E +QD I E+ A + + + A+ A
Sbjct: 546 LEQRLMQLMESEQKRVNKEESLQMQVQD----ILEQNEALKAQIQQFHSQIAAQTSASVL 601
Query: 363 AEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQN 422
AE L+ + K +K+ ++ L + L ++ + + + K ++++A N
Sbjct: 602 AEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAE--VQKLQALAN 659
Query: 423 QENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGP 482
++ + E+E+ QQ++ + KI+ E ++H +S + K L D K
Sbjct: 660 EQAAAAHELEKMQQSVYVKDD---KIRLLEEQLQHEISNKMEEFKILNDQN----KALKS 712
Query: 483 NVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADE 542
V L + + + V + CI +D +L E GL+Q E
Sbjct: 713 EVQKLQTLVSEQPNKD-----VVEQMEKCIQEKDEKLKTVEELLETGLIQVA-----TKE 762
Query: 543 RVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSL 602
L A+ S E+ D++ + F +++ L+ V+
Sbjct: 763 EELNAIRTEN------------SSLTKEVQDLKAKQNDQVSFASLVEELK---KVIHEKD 807
Query: 603 IDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSR 662
++ +E +L + VA +K ++ ++ A +++ + ++
Sbjct: 808 GKIKSVEELLEAELLKVAN----KEKTVQDLKQEIKALKEEIGNVQLEKAQQL------- 856
Query: 663 DVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRK--- 719
+ S++ +L+N ++ K Q+ ++ L EKD+ + + L+ Q + LK +++
Sbjct: 857 SITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQ 916
Query: 720 -NISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAEN 778
N+ E EE LE +E ++++K +E +++++ ++ L + ++
Sbjct: 917 HNLKEASSASQFEE--------LEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQD 968
Query: 779 KYDAIKFKINQLSEL------ADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKK 832
+ K +I QL + + P +EL SE + + G + + K+ ++ KK
Sbjct: 969 ENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKK 1028
Query: 833 KRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIM 892
E + + +E + + + ++ V + S + ++ +K + A EE+
Sbjct: 1029 NNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSY-GEWLHGFEKKAKECMAGTSGSEEV- 1086
Query: 893 RQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQR 952
+++EH+ K + L L C+ Y L
Sbjct: 1087 ----------------------------KVLEHKLKEADEMHTLLQLECEKYKSVLAETE 1118
Query: 953 AYCGKMNFDHKNETLSISVQPGEGNK 978
K+ + E V+ E +K
Sbjct: 1119 GILQKLQRSVEQEENKWKVKVDESHK 1144
Score = 62.0 bits (149), Expect = 3e-09
Identities = 139/742 (18%), Positives = 303/742 (40%), Gaps = 128/742 (17%)
Query: 214 TQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKT---- 269
T + E+ ++ K++ QI Q E+ L + + KEE + I ++ +
Sbjct: 596 TSASVLAEELHKVIAEKDK---QIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQ 652
Query: 270 NLESLKHEMAWAVVNEIEKQLNAIR---DNIKIGEDRAAR-LDRKMEE------------ 313
L++L +E A A +E+EK ++ D I++ E++ + KMEE
Sbjct: 653 KLQALANEQA-AAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALK 711
Query: 314 ---QQVRLNEAEQKYKDIQDKLEKISEETNAR---APECMALKADVVAKKRAYNEAEVLY 367
Q+++ +EQ KD+ +++EK +E + + E + VA K A
Sbjct: 712 SEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTE 771
Query: 368 NRSLN----EYKALKKDDEQLCKRIEELKK----------STDQSLEPERLE---RQKKI 410
N SL + KA + D +EELKK S ++ LE E L+ ++K +
Sbjct: 772 NSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTV 831
Query: 411 SWLKERVKAFQN----------QENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALS 460
LK+ +KA + Q+ S+ ++++ Q ++ +E+ +K + + L+
Sbjct: 832 QDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLA 891
Query: 461 YNQRQLKELKDSKTDRLKRFGPNVPA--LLEAIDDA-YRQGHFTYKP----VGPLGACIH 513
+ L++L++ + + LK V L EA + + + K + L A +
Sbjct: 892 NTGKWLQDLQE-ENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLK 950
Query: 514 LRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYD 573
R+ +L+ + LLQ N + ++ L ++ Y +S PP
Sbjct: 951 ERESDLSSKTQ-----LLQDVQDENKLFKSQIEQLKQQNYQQASSFPP------------ 993
Query: 574 VRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNC 633
H + V++ E + + + N L ++ ++ Q+ N
Sbjct: 994 -------HEELLKVISEREKEISGLWNELDSLKD---------------AVEHQRKKNNE 1031
Query: 634 REAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLE--NEVENKTAQIL---NLQQH 688
R+ QV A + E + F V S +S E + E K + + + +
Sbjct: 1032 RQ------QQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEE 1085
Query: 689 LSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQEN 748
+ LE +K +E+ QL ++ K + + +++L+ E + DE+ +
Sbjct: 1086 VKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKT 1145
Query: 749 KSKMKMVEEHMEQQKENMEHLKSLKIEAEN---KYDAIKFKINQLSELADPLKDELNLAD 805
+K ++ ++ +E L+S + EN + + ++ ++ + E+
Sbjct: 1146 ---IKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELK 1202
Query: 806 SEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKEL-----EEKMSQARQICPERIEV 860
++++ R + ++++ L+K ++ L++ + ++ + + + + PE
Sbjct: 1203 AQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESS 1262
Query: 861 EKS--ASILDKEINRLRQKIQA 880
EK + L++ + +L+Q +QA
Sbjct: 1263 EKETMSVSLNQTVTQLQQLLQA 1284
Score = 56.6 bits (135), Expect = 1e-07
Identities = 133/732 (18%), Positives = 281/732 (38%), Gaps = 114/732 (15%)
Query: 268 KTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKD 327
K L +L H++ E +K L A++++ +DR +L ++M ++ R N + KD
Sbjct: 324 KGELTTLIHQL-----QEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKD 378
Query: 328 -----------IQDKLEKISEETNARAPECMALKADV------------VAKKRAYNEAE 364
Q+K+ +ET + ++ + + + N
Sbjct: 379 RIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTN 438
Query: 365 VLYNRSLNEYKALKKDDEQLCKRIEE----LKKSTDQSLEPERLERQKKISWLKERVKAF 420
L ++ E L++D +L + E L++ Q E+ Q K+ L+E + +
Sbjct: 439 QLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQ-LQEAERRW 497
Query: 421 QNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYN--------QRQLKELKDS 472
+ ++ + + + +A ++D + K E+ H+ + +++L +L +S
Sbjct: 498 EEVQSYIRKRTAE-HEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMES 556
Query: 473 KTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQ 532
+ R+ + +L + D Q + + I + LA E
Sbjct: 557 EQKRVNK----EESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEE-------- 604
Query: 533 AYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALE 592
H E+ Q L + R + E E+ D+++ L AL
Sbjct: 605 ---LHKVIAEKDKQIKQTEDSL-ASERDRLTSKE--EELKDIQNMNFLLKAEVQKLQALA 658
Query: 593 IDNAVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSS 652
+ A A+ L M + + +K++ + Q Q N E F DQ + S
Sbjct: 659 NEQAAAAHELEKM---QQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQ---NKALKS 712
Query: 653 ENTRPKFL-----SRDV-----------DSEISDLENEVENKTAQILNLQQHLSALE--- 693
E + + L ++DV D ++ +E +E Q+ ++ L+A+
Sbjct: 713 EVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTEN 772
Query: 694 -------KDIKHNEELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQ 746
+D+K + +ELK I + +I+ +E + E + + +A E Q
Sbjct: 773 SSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQ 832
Query: 747 ENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSE----LADPLKDELN 802
+ K ++K ++E + + S+ + + + +K K Q++ L + KD N
Sbjct: 833 DLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLAN 892
Query: 803 ----LADSEVDNQKRGKRHYEEKQKEHLD-------------TLNKKKRELDMKEKELEE 845
L D + +N+ K H +E + +L L +K+ EL E L+E
Sbjct: 893 TGKWLQDLQEENESL-KAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKE 951
Query: 846 KMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARETYLDL 905
+ S +V+ + +I +L+Q+ + +S EE+++ E + L
Sbjct: 952 RESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGL 1011
Query: 906 DSKVRTLKKFIK 917
+++ +LK ++
Sbjct: 1012 WNELDSLKDAVE 1023
Score = 52.0 bits (123), Expect = 3e-06
Identities = 75/375 (20%), Positives = 161/375 (42%), Gaps = 62/375 (16%)
Query: 155 KLKSATGSVVSTRKEELIAILDHFNIQVDNPVSVLTQEMSK--------QFLQSKNEGDK 206
+L+ A ++++ +EL +L Q++ +VL ++ Q LQ +NE K
Sbjct: 849 QLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLK 908
Query: 207 Y------KFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQS 260
+ +K E+ +++ KE +++ E L E + K + Q
Sbjct: 909 AHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRL---EAMLKERESDLSSKTQLLQD 965
Query: 261 IAGLSTM-KTNLESLK------------HEMAWAVVNEIEKQLNAIRDNIKIGEDRAARL 307
+ + + K+ +E LK HE V++E EK+++ + + + +D
Sbjct: 966 VQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQ 1025
Query: 308 DRKMEEQQVRLNEAEQKYKDIQDKL-EKISEETN-----------ARAPECMALKAD--- 352
+K E+Q ++ E + K++ KL K+S +N +A ECMA +
Sbjct: 1026 RKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEE 1085
Query: 353 ---VVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKK 409
+ K + +E L +YK++ + E + ++++ +S+E E + + K
Sbjct: 1086 VKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQ-------RSVEQEENKWKVK 1138
Query: 410 ISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQR----- 464
+ + +K Q+ S QE+E+ + E E+ + +RE L+++ + +R
Sbjct: 1139 VDESHKTIKQMQSSFTSSEQELERLRS--ENKDIENLRREREHLEMELEKAEMERSTYVT 1196
Query: 465 QLKELKDSKTDRLKR 479
+++ELK + L +
Sbjct: 1197 EVRELKAQLNETLTK 1211
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 93.6 bits (231), Expect = 9e-19
Identities = 132/683 (19%), Positives = 285/683 (41%), Gaps = 120/683 (17%)
Query: 212 KATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEK-EERFQSIAGLSTMKTN 270
KA + + S + + + + + Q E L E K++ ++ +E + + ++ +
Sbjct: 1357 KAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCAS 1416
Query: 271 LESLKHEMAWAVVNEIEK-QLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQ 329
LE K + NE+E L+ R N A LD+K L+E +QKY++ Q
Sbjct: 1417 LEKTKQRLQ----NEVEDLMLDVERSNAA-----CAALDKKQRNFDKVLSEWKQKYEETQ 1467
Query: 330 DKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIE 389
+LE +E+ + + E +K +Y SL++ + L+++++ L + I
Sbjct: 1468 AELEASQKESRSLSTELFKVKN--------------VYEESLDQLETLRRENKNLQQEIS 1513
Query: 390 ELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEHGKIK 449
+L + E K+I L++ K + ++ + +E+ + ++E E GKI
Sbjct: 1514 DLTEQI--------AEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLE---HEEGKIL 1562
Query: 450 REELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLG 509
R +L++ S R++ E KD + D+LKR V +++ DA
Sbjct: 1563 RIQLELNQVKSEVDRKIAE-KDEEIDQLKRNHTRVVETMQSTLDA--------------- 1606
Query: 510 ACIHLRDPELALAIESCLKGLLQAYCCH-NHADERVLQALMKRFYLPGTSRPPIIVSEFR 568
+R AL ++ ++G L NHA+ ++L G I+ E
Sbjct: 1607 ---EIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQG------ILKE-- 1655
Query: 569 NEIYDVRHRAAYHPDFPTVLTALEIDNAV-----VANSLIDMRGIETVLLIKNNSVARAV 623
T L +D+A+ + L + +L + + +
Sbjct: 1656 --------------------TQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATL 1695
Query: 624 MQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQIL 683
Q+++ K + ++V + ++NT + +++++S L++EVE +
Sbjct: 1696 EQTERSRKIAEQELLDASERV---QLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESR 1752
Query: 684 NLQQHLSALEKDIKHNEELLKRCQ---LHYKELKMKIRKNISEIRELENIEEHQSVDIAT 740
N ++ D E LK+ Q H + +K + + + +++ ++E + + +
Sbjct: 1753 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQH--RLDEAEQLALKG 1810
Query: 741 LEDEAQENKSKMKMVEEHME-QQKENMEHLKSLKIEAENKYDAIKFKINQLSELADPLKD 799
+ + Q+ +++++ +E +E +QK N E +K L+ + E + + ++ + + L+D
Sbjct: 1811 GKKQIQKLEARVRELEGEVENEQKRNAEAVKGLR-KHERRVKELTYQTEEDRKNVLRLQD 1869
Query: 800 ELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIE 859
++ ++V + KR EE+ +L K + EL+ E
Sbjct: 1870 LVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELE---------------------E 1908
Query: 860 VEKSASILDKEINRLRQKIQAEH 882
E+ A I + ++N+LR K + H
Sbjct: 1909 AEERADIAESQVNKLRVKSREVH 1931
Score = 56.6 bits (135), Expect = 1e-07
Identities = 56/279 (20%), Positives = 124/279 (44%), Gaps = 45/279 (16%)
Query: 664 VDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISE 723
++ ++ DLE +E + ++L++ LE D+K +E + ++L K+ K E
Sbjct: 1030 LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFE 1089
Query: 724 IREL-ENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDA 782
I L IE+ Q+V+I + + K+K ++ +E+ E +E ++ + +AE +
Sbjct: 1090 ISNLISKIEDEQAVEI--------QLQKKIKELQARIEELGEEIEAERASRAKAEKQRSD 1141
Query: 783 IKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQK------------------- 823
+ +L E+++ L++ ++V+ K+ + +++ ++
Sbjct: 1142 LS---RELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKK 1198
Query: 824 ---------EHLDTLNKKKRELDMKEKEL----EEKMSQARQICPERIEVEKSASILDKE 870
E +D L + K++L+ ++ EL ++ S A I + +EK L+ +
Sbjct: 1199 HADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQ 1258
Query: 871 INRLRQKIQAEHASHGD-REEIMRQYQEARETYLDLDSK 908
++ L+ K + + D + R EA E LD K
Sbjct: 1259 VSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEK 1297
Score = 54.7 bits (130), Expect = 5e-07
Identities = 74/351 (21%), Positives = 153/351 (43%), Gaps = 35/351 (9%)
Query: 142 IQQHISIDGSRSYKLKSATGSVVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSK 201
+ + I+ G + ++L+ V K E+ A L+ +++ + + + + Q K
Sbjct: 1515 LTEQIAEGGKQIHELEKIKKQV-EQEKCEIQAALEEAEASLEHEEGKILR-IQLELNQVK 1572
Query: 202 NEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSI 261
+E D+ K K +++Q+K +++ ++ET + T + + +K++ +E + I
Sbjct: 1573 SEVDR-KIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKK-MEGDLNEMEI 1630
Query: 262 AGLSTMKTNLESLK-HEMAWAVVNEIEKQLNA-------IRDNIKIGEDRAARLDRKMEE 313
+ ESL+ + ++ E + L+ +++ + I E RA L ++EE
Sbjct: 1631 QLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEE 1690
Query: 314 QQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYN-------EAEVL 366
L + E+ K + +L SE + +L + KK+ N E E +
Sbjct: 1691 LWATLEQTERSRKIAEQELLDASERVQLLHTQNTSL---INTKKKLENDVSQLQSEVEEV 1747
Query: 367 YNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENS 426
S N + KK EELKK D S ER+++ L++ VK Q++ +
Sbjct: 1748 IQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN-----LEQTVKDLQHRLDE 1802
Query: 427 VNQEI-----EQFQQAIEKDKEEHGKIKREE---LDVKHALSYNQRQLKEL 469
Q +Q Q+ + +E G+++ E+ + L ++R++KEL
Sbjct: 1803 AEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKEL 1853
Score = 53.5 bits (127), Expect = 1e-06
Identities = 142/741 (19%), Positives = 294/741 (39%), Gaps = 85/741 (11%)
Query: 206 KYKFFMKATQLEQ----MKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSI 261
K K +K+ + E+ MKE++ + +++ + + EE++ L ++ + + + QS
Sbjct: 838 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSE 897
Query: 262 AG-----------LSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRK 310
A L K LE+ E+ E E K+ ED + L +
Sbjct: 898 ADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKL-EDECSELKKD 956
Query: 311 MEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEA-EVLYNR 369
+++ ++ L + E++ ++K++ ++EE MA + +AK +A + + +
Sbjct: 957 IDDLELTLAKVEKEKHATENKVKNLTEE--------MAGLDETIAKLSKEKKALQETHQQ 1008
Query: 370 SLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQ 429
+L++ +A + L K +L++ D LE LE++KK+ ER K + + Q
Sbjct: 1009 TLDDLQAEEDKVNILTKAKTKLEQQVD-DLEGS-LEQEKKLRMDLERAKRKLEGDLKLAQ 1066
Query: 430 EIEQFQQAIEKDKEE-HGKIKREELDVKHALS-YNQRQLKELKDSKTDRLKRFGPNVPAL 487
E +E DK++ K++++E ++ + +S Q E++ K ++K + L
Sbjct: 1067 E---STMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQK--KIKELQARIEEL 1121
Query: 488 LEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQA 547
E I+ K L + E++ +E G A N E Q
Sbjct: 1122 GEEIEAERASRAKAEKQRSDLSRELE----EISERLEEA-GGATSAQVELNKKREAEFQK 1176
Query: 548 LMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRG 607
L +R T + +V+ R + H D L +IDN ++
Sbjct: 1177 L-RRDLEEATLQHEAMVAALRKK----------HADSMAEL-GEQIDNLQRVKQKLEKEK 1224
Query: 608 IETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSE 667
E L ++ + ++ K N + + DQV + E R L D+ ++
Sbjct: 1225 SE--LKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQR---LINDLTAQ 1279
Query: 668 ISDLENE-------VENKTAQILNLQQHLSALE---KDIKHNEELLKRCQLHYKELKMKI 717
+ L+ E ++ K A + L + A +++KH E + +
Sbjct: 1280 RARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSS 1339
Query: 718 RKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEE-----HMEQQKENMEHLKSL 772
R + +RE E+ ++ +A ++ + E E+ +E + L
Sbjct: 1340 RHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1399
Query: 773 KIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKK 832
EAE +A+ K L + L++E+ +V+ ++KQ+ L++
Sbjct: 1400 LQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEW 1459
Query: 833 KRELDMKEKELEEKMSQARQICPERIEVEK-------SASILDKEINRLRQKIQ--AEHA 883
K++ + + ELE ++R + E +V+ L +E L+Q+I E
Sbjct: 1460 KQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQI 1519
Query: 884 SHGDR-----EEIMRQYQEAR 899
+ G + E+I +Q ++ +
Sbjct: 1520 AEGGKQIHELEKIKKQVEQEK 1540
Score = 53.5 bits (127), Expect = 1e-06
Identities = 138/778 (17%), Positives = 314/778 (40%), Gaps = 131/778 (16%)
Query: 216 LEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGL----STMKTNL 271
+ ++ ++ + ET ++T + + E+++ L + + E++ + G ++ +L
Sbjct: 992 IAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDL 1051
Query: 272 ESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKD---I 328
E K ++ E L +++ E+ +LD K+E+++ ++ K +D +
Sbjct: 1052 ERAKRKL--------EGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAV 1103
Query: 329 QDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRI 388
+ +L+K +E AR E L ++ A++ + +AE + L ++ E++ +R+
Sbjct: 1104 EIQLQKKIKELQARIEE---LGEEIEAERASRAKAE-------KQRSDLSRELEEISERL 1153
Query: 389 EELKKSTDQSLEP--------ERLERQKKISWLKERV------KAFQNQENSVNQEIEQF 434
EE +T +E ++L R + + L+ K + + ++I+
Sbjct: 1154 EEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNL 1213
Query: 435 QQAIEKDKEEHGKIKREELDVK---HALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAI 491
Q+ +K ++E ++K E D+ A+S + L+++ S D++ I
Sbjct: 1214 QRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLI 1273
Query: 492 DDAYRQGHFTYKPVGPLGACIHLRDPELALAIESC---------LKGLLQAYCCHNHADE 542
+D Q G + +D ++ S LK L+ +A
Sbjct: 1274 NDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALA 1333
Query: 543 RVLQA------LMKRFY---LPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEI 593
LQ+ L++ Y G + +S+ +E+ + R Y D LE
Sbjct: 1334 HALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEV--AQWRTKYETDAIQRTEELEE 1391
Query: 594 DNAVVANSLIDM-RGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSS 652
+A L + +E V N+ ++ ++++ +N E D ++ A
Sbjct: 1392 AKKKLAQRLQEAEEHVEAV-----NAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALD 1446
Query: 653 ENTRPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDI----KHNEELLKRCQL 708
+ R + D +S+ + + E A++ Q+ +L ++ EE L + +
Sbjct: 1447 KKQR------NFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLET 1500
Query: 709 HYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEH 768
+E K +++ IS++ E Q ++ ++ + ++ K + ++ +E+ + ++EH
Sbjct: 1501 LRRENK-NLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCE---IQAALEEAEASLEH 1556
Query: 769 LKSLKIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDT 828
E K I+ ++NQ+ D ++ D E+D KR E + LD
Sbjct: 1557 -------EEGKILRIQLELNQVKSEVD---RKIAEKDEEIDQLKRNHTRVVETMQSTLDA 1606
Query: 829 ---------LNKKKRELDMKEKELEEKMSQARQICPERI--------------------- 858
KKK E D+ E E++ ++ A ++ E +
Sbjct: 1607 EIRSRNDALRVKKKMEGDLNEMEIQ--LNHANRLAAESLRNYRNTQGILKETQLHLDDAL 1664
Query: 859 ----EVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARETYLDLDSKVRTL 912
++++ +I+++ N L+ +I+ A+ E+ R + A + LD +V+ L
Sbjct: 1665 RGQEDLKEQLAIVERRANLLQAEIEELWAT---LEQTERSRKIAEQELLDASERVQLL 1719
Score = 48.1 bits (113), Expect = 4e-05
Identities = 49/243 (20%), Positives = 97/243 (39%), Gaps = 39/243 (16%)
Query: 662 RDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNI 721
R ++ E S+L+ ++++ L+ L+ +EK+ E +K L I K
Sbjct: 944 RKLEDECSELKKDIDD-------LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLS 996
Query: 722 SEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYD 781
E + L+ + D+ ED+ +E+ ++ + ++E K L+++
Sbjct: 997 KEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMD------ 1050
Query: 782 AIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEK 841
L L+ +L LA + + K+ +EK L+ KE
Sbjct: 1051 --------LERAKRKLEGDLKLAQESTMDMENDKQQLDEK--------------LEKKEF 1088
Query: 842 ELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHG----DREEIMRQYQE 897
E+ +S+ I+++K L I L ++I+AE AS R ++ R+ +E
Sbjct: 1089 EISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEE 1148
Query: 898 ARE 900
E
Sbjct: 1149 ISE 1151
Score = 43.5 bits (101), Expect = 0.001
Identities = 49/288 (17%), Positives = 123/288 (42%), Gaps = 33/288 (11%)
Query: 661 SRDVDSEISDLENEVENKTAQIL---NLQQHLSALEKDIKHNEELLKRCQLHYKELKMKI 717
+R V++ S L+ E+ ++ + ++ L+ +E + H L +Y+ + +
Sbjct: 1594 TRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGIL 1653
Query: 718 RKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAE 777
++ + + +E +A +E A +++++ + +EQ + + + + ++A
Sbjct: 1654 KETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDAS 1713
Query: 778 NKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHL----------- 826
+ + + L L+++++ SEV+ + R+ EEK K+ +
Sbjct: 1714 ERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELK 1773
Query: 827 ---DT---LNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQA 880
DT L + K+ L+ K+L+ ++ +A Q+ + +K L+ + L +++
Sbjct: 1774 KEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALK--GGKKQIQKLEARVRELEGEVEN 1831
Query: 881 EHASHGDR-----------EEIMRQYQEARETYLDLDSKVRTLKKFIK 917
E + + +E+ Q +E R+ L L V L+ +K
Sbjct: 1832 EQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVK 1879
Score = 40.4 bits (93), Expect = 0.009
Identities = 66/359 (18%), Positives = 141/359 (39%), Gaps = 40/359 (11%)
Query: 660 LSRDVDSEISDLENEVENKTAQ----ILNLQQH----LSALEKDIKHNEELLKRCQLHYK 711
L++ ++E L ++E T Q + L++ ++ L + I + + + ++ +
Sbjct: 1166 LNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKS 1225
Query: 712 ELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKS 771
ELKM+ S + + + +LED+ E K+K + + + L++
Sbjct: 1226 ELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQT 1285
Query: 772 LKIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKR---HYEEKQKEHLDT 828
E + D ++QLS ++ +++ + + K H + + D
Sbjct: 1286 EAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDL 1345
Query: 829 LNKKKRELDMKEKELEEKMSQAR-QICPERIEVEKSASILDKEINRLRQK---------- 877
L ++ E + EL+ +S+A ++ R + E A +E+ ++K
Sbjct: 1346 LREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEE 1405
Query: 878 -IQAEHASHGDREEIMRQYQ-EARETYLD----------LDSKVRTLKKFI---KLLGEI 922
++A +A E+ ++ Q E + LD LD K R K + K E
Sbjct: 1406 HVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEE 1465
Query: 923 MEHRFKTYQQFRRCLT---LRCKLYFDNLLSQRAYCGKMNFDHKNETLSISVQPGEGNK 978
+ + Q+ R L+ + K ++ L Q + N + + E ++ Q EG K
Sbjct: 1466 TQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGK 1524
Score = 30.4 bits (67), Expect = 9.5
Identities = 23/92 (25%), Positives = 42/92 (45%), Gaps = 1/92 (1%)
Query: 823 KEHLDTLNKKKRELDMKEKELEEKM-SQARQICPERIEVEKSASILDKEINRLRQKIQAE 881
KE + + + K KELEEKM + ++ +++V+ A L R Q I+ +
Sbjct: 856 KEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNK 915
Query: 882 HASHGDREEIMRQYQEARETYLDLDSKVRTLK 913
+E+ + +E E +L +K R L+
Sbjct: 916 IQLEAKIKEVTERAEEEEEINAELTAKKRKLE 947
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 89.0 bits (219), Expect = 2e-17
Identities = 146/735 (19%), Positives = 297/735 (40%), Gaps = 104/735 (14%)
Query: 199 QSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERF 258
Q+K E + K ++A Q+++++ S + +++H+ + + + E E +
Sbjct: 1245 QAKQEVEHKKKKLEA-QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303
Query: 259 ----QSIAGLSTMKTNLESLKHEMAWAVVN------EIEKQLNAIRDNIKIGEDRAARLD 308
+ +A LS+ + + L E +N ++E++ N+++D + + L+
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363
Query: 309 RKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYN 368
R + ++L+++++K +D +E + E E L K AY++ E N
Sbjct: 1364 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1423
Query: 369 RSLNEYKALKKD---DEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQEN 425
R E L D QL +E+ ++ DQ L E+ K + ++R +A ++
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK-NISSKYADERDRAEAEAREKE 1482
Query: 426 ----SVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFG 481
S+ + +E+ +A E+ + + +K E D+ + + + EL+ SK L+
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR-ALETQM 1541
Query: 482 PNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIE-SCLKGL----LQAYCC 536
+ LE ++D + D +L L + LKG LQA
Sbjct: 1542 EEMKTQLEELEDELQA----------------TEDAKLRLEVNMQALKGQFERDLQARDE 1585
Query: 537 HNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNA 596
N R LQ + E+ E+ D R + A L D
Sbjct: 1586 QNEEKRRQLQRQLH---------------EYETELEDERKQRALAAAAKKKLEGDLKDLE 1630
Query: 597 VVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTR 656
+ A+S I +G E + R + K + E A D++FA +
Sbjct: 1631 LQADSAI--KGREEAI-----KQLRKLQAQMKDFQRELEDARASRDEIFATA--KENEKK 1681
Query: 657 PKFLSRDV-----------------DSEISDLENEVENKTAQILNLQQHLSALEKDIKHN 699
K L D+ D E +L E+ + + LQ LE I
Sbjct: 1682 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1741
Query: 700 EELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHM 759
EE L+ Q + + + ++RK + +L N ++AT AQ+N+S + +E
Sbjct: 1742 EEELEEEQGNMEAMSDRVRKATQQAEQLSN-------ELATERSTAQKNESARQQLERQN 1794
Query: 760 EQQKENMEHLK-SLKIEAENKYDAIKFKINQLSELADPLKDELNLADS------------ 806
++ + + ++ ++K + ++ A++ KI QL E + E A
Sbjct: 1795 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1854
Query: 807 --EVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSA 864
+V+++++ Y+E+ ++ + + KR+L+ E+E + + R++ E E +S
Sbjct: 1855 LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESN 1914
Query: 865 SILDKEINRLRQKIQ 879
+ +E+N L+ K++
Sbjct: 1915 EAMGREVNALKSKLR 1929
Score = 82.0 bits (201), Expect = 3e-15
Identities = 147/745 (19%), Positives = 329/745 (44%), Gaps = 69/745 (9%)
Query: 215 QLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESL 274
Q+ + +E+ + ++TKE+ + E L EL+++ + E + +T L +
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 275 KHEMAWAVV---NEIEKQLNAIRDNIKIGEDRAARLD---RKMEEQQVRLNEAEQKYKDI 328
EM + E+E+ L+ + ++ EDR +L +KM +Q + L E ++ +
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 329 QDKL--EKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCK 386
+ KL EK++ E + E L D K + E ++L R +++ ++E+ K
Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS-KERKLLEER-ISDLTTNLAEEEEKAK 1023
Query: 387 RIEELKKSTDQSLEP--ERLERQKKISWLKERVKA-FQNQENSVNQEIEQFQQAIEKDKE 443
+ +LK + + RL++++K E++K + + +++I Q I + K
Sbjct: 1024 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1083
Query: 444 EHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYK 503
+ K K EEL AL+ ++ + K++ +++ ++ L E +D + K
Sbjct: 1084 QLAK-KEEELQA--ALARLDDEIAQ-KNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1139
Query: 504 PVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPII 563
LG + EL ++S A ++ L+A ++ T +
Sbjct: 1140 QKRDLGEELEALKTELEDTLDST-------------ATQQELRAKREQEV---TVLKKAL 1183
Query: 564 VSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVA--- 620
E R+ V+ H LT +++ A + +D + L +N +A
Sbjct: 1184 DEETRSHEAQVQEMRQKHAQAVEELTE-QLEQFKRAKANLDKN--KQTLEKENADLAGEL 1240
Query: 621 RAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTA 680
R + Q+++ ++ ++ A QV + S+ R + +++ ++ L+NEVE+ T
Sbjct: 1241 RVLGQAKQEVEHKKKKLEA---QVQELQSKCSDGERAR---AELNDKVHKLQNEVESVTG 1294
Query: 681 QI-------LNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIREL-----E 728
+ + L + +++L ++ +ELL+ + K+R+ E L E
Sbjct: 1295 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE 1354
Query: 729 NIEEHQSVD--IATLEDEAQENKSKMK----MVEEHMEQQKENMEHLKSLKIEAENK--- 779
+E Q+++ I+TL + ++K K++ VE E +K + +++L + E K
Sbjct: 1355 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1414
Query: 780 YDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMK 839
YD ++ N+L + D L +L+ V N ++ +R +++ E + +K E D
Sbjct: 1415 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1474
Query: 840 EKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEAR 899
E E EK ++A + E ++ L++ L+ +++ +S ++++ + E
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS---KDDVGKNVHELE 1531
Query: 900 ETYLDLDSKVRTLKKFIKLLGEIME 924
++ L++++ +K ++ L + ++
Sbjct: 1532 KSKRALETQMEEMKTQLEELEDELQ 1556
Score = 76.6 bits (187), Expect = 1e-13
Identities = 160/861 (18%), Positives = 355/861 (41%), Gaps = 100/861 (11%)
Query: 186 VSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLT 245
+ V QE Q + + + K + +L+++++ +S + E K +EQ+ Q E T
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL-QAE---T 900
Query: 246 ELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEK--QLNAIRDNI------ 297
EL + E R L+ K LE + HEM + E ++ QL A R +
Sbjct: 901 ELYAEAEEMRVR------LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 954
Query: 298 ---KIGEDRAARLDRKMEE--QQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKAD 352
++ E+ AAR ++E+ + ++ + E + + D+ K+S+E L +
Sbjct: 955 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014
Query: 353 VVAKKRAYNEAEVLYNRS---LNEYKALKKDDEQLCKRIEELKKSTD---QSLEPERLER 406
+ ++ L N+ ++E + K +E+ + +E+LK+ + + +
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1074
Query: 407 QKKISWLKERVKAFQNQENS----VNQEIEQFQQAIEKDKEEHGKIK--REELDVKHALS 460
Q +I+ LK ++ + + + ++ EI Q A++K +E G I +E+LD + A
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1134
Query: 461 YNQRQLK-----ELKDSKTD--------------RLKRFGPNVPALLEAIDDAYRQGHFT 501
+ K EL+ KT+ R KR V L +A+D+ R
Sbjct: 1135 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR-EQEVTVLKKALDEETRSHE-- 1191
Query: 502 YKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPP 561
A + + A A+E + L Q + D+ + L G R
Sbjct: 1192 --------AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR-- 1241
Query: 562 IIVSEFRNEIYDVRHRA-AYHPDFPTVLTALEIDNAVVANSLIDMRG-IETVLLIKNNSV 619
++ + + E+ + + A + + + E A + + + ++ +E+V + N +
Sbjct: 1242 -VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1300
Query: 620 ARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKT 679
+A+ ++ + D ++ N K R ++ E + L+++++ +
Sbjct: 1301 GKAIKLAKDVASLSSQL--QDTQELLQEETRQKLNVSTKL--RQLEEERNSLQDQLDEEM 1356
Query: 680 AQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIA 739
NL++H+S L + +++ L+ + L+ + +K +E+EN+ + Q + A
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE-EGKKRFQ--KEIENLTQ-QYEEKA 1412
Query: 740 TLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSELADPLKD 799
D+ ++ K++++ + + +N L S + + K+D + + + ++ D
Sbjct: 1413 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL---LAEEKNISSKYAD 1469
Query: 800 ELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIE 859
E + A++E ++ +E L+ + +R M + E+E+ +S + E
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529
Query: 860 VEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLL 919
+EKS L+ ++ ++ ++ EE+ + Q + L L+ ++ LK +
Sbjct: 1530 LEKSKRALETQMEEMKTQL----------EELEDELQATEDAKLRLEVNMQALKGQFE-- 1577
Query: 920 GEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQR-----AYCGKMNFDHKNETLSISVQPG 974
++ R + ++ RR L + Y L +R A K + + L +
Sbjct: 1578 -RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1636
Query: 975 -EGNKAAFNDMRALSGGERSF 994
+G + A +R L + F
Sbjct: 1637 IKGREEAIKQLRKLQAQMKDF 1657
Score = 71.2 bits (173), Expect = 5e-12
Identities = 151/817 (18%), Positives = 332/817 (40%), Gaps = 87/817 (10%)
Query: 155 KLKSATGSVVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKA- 213
+L+ T + E+ I ++D N ++ +L + +S E +K K K
Sbjct: 970 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1029
Query: 214 TQLEQMKEDYSYIMETKERTK------------------EQIHQGEERLTELKRQCVEKE 255
+ E M + ++ +E+++ EQI + ++ ELK Q +KE
Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089
Query: 256 ERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQ 315
E Q+ + + + E + A + E+E ++ ++++ + +RAAR K E+Q+
Sbjct: 1090 EELQA----ALARLDDEIAQKNNALKKIRELEGHISDLQED--LDSERAAR--NKAEKQK 1141
Query: 316 VRLNEAEQKYK-DIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEY 374
L E + K +++D L+ + + RA + +V K+A +E + + E
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKR----EQEVTVLKKALDEETRSHEAQVQEM 1197
Query: 375 KALKKDD-EQLCKRIEELKKS------TDQSLEPERLERQKKISWLKERVKAFQNQENSV 427
+ E+L +++E+ K++ Q+LE E + ++ L + + ++++ +
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 428 NQEIEQFQQAIEKDKEEHGKIKREELDVK-HALSYNQRQLKELKDSKTDRLKRFGPNVPA 486
++++ Q K G+ R EL+ K H L + + + + + +V +
Sbjct: 1258 EAQVQELQ-----SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312
Query: 487 LLEAIDDAYRQGHFTYKPVGPLGACIHLRD-PELALAIESCLKGLLQA-YCCHNHADERV 544
L + D Q + L LR E +++ L ++A H
Sbjct: 1313 LSSQLQDT--QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1370
Query: 545 LQALMKRFYLPGTSRPPIIVSE----FRNEIYDV----RHRAAYHPDFPTVLTAL--EID 594
+Q + L + + E F+ EI ++ +AA + L E+D
Sbjct: 1371 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1430
Query: 595 NAVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSEN 654
+ VV L + R + + L K + + + KN + + D+ A +
Sbjct: 1431 DLVV--DLDNQRQLVSNLEKKQRKFDQLLAEE----KNISSKYADERDRAEAEA--REKE 1482
Query: 655 TRPKFLSRDVDSEI---SDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYK 711
T+ L+R ++ + +LE + A++ +L + K++ E+ + + +
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542
Query: 712 ELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKS 771
E+K ++ + E++ E+ + V++ L+ + + + E +Q + H
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1602
Query: 772 LKIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNK 831
++E E K A+ + +L LKD ADS + + ++E + L K
Sbjct: 1603 TELEDERKQRALAAAAKK--KLEGDLKDLELQADSAI-----------KGREEAIKQLRK 1649
Query: 832 KKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHG----D 887
+ ++ ++ELE+ + +I E EK A L+ ++ +L++ + A + +
Sbjct: 1650 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1709
Query: 888 REEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIME 924
+EE+ + + L + R L+ I L E +E
Sbjct: 1710 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1746
Score = 63.2 bits (152), Expect = 1e-09
Identities = 132/707 (18%), Positives = 292/707 (41%), Gaps = 96/707 (13%)
Query: 256 ERFQSIAGLSTMKTNLES---LKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKME 312
+R Q + + ++ N + L++ W + +++ L R E+ A+ D +++
Sbjct: 808 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQE----EEMQAKED-ELQ 862
Query: 313 EQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLN 372
+ + R +AE + K+++ K +++EE N L+ + A+ Y EAE + R
Sbjct: 863 KTKERQQKAENELKELEQKHSQLTEEKNL-------LQEQLQAETELYAEAEEMRVRLAA 915
Query: 373 EYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIE 432
+ + L++ ++ R+EE ++ Q L+ ER + +++ L+E+++ +E + Q+++
Sbjct: 916 KKQELEEILHEMEARLEE-EEDRGQQLQAERKKMAQQMLDLEEQLE----EEEAARQKLQ 970
Query: 433 QFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAID 492
+EK E KIK+ E ++ N + KE K +R+ N+ E
Sbjct: 971 -----LEKVTAE-AKIKKLEDEILVMDDQNNKLSKERK-LLEERISDLTTNLAEEEEKAK 1023
Query: 493 DAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRF 552
+ + + + L + L+ E + LK L+ H LQA
Sbjct: 1024 NLTKLKNKHESMISELE--VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ---- 1077
Query: 553 YLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVL 612
++E + ++ A + L L+ + A N+L +R +E +
Sbjct: 1078 -----------IAELKMQL------AKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1120
Query: 613 LIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENT-----RPKFLSRDVDSE 667
S + + S++ +N E D + E+T + L + E
Sbjct: 1121 -----SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE 1175
Query: 668 ISDLENEVENKT----AQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISE 723
++ L+ ++ +T AQ+ ++Q + +++ E KR + + + K + K ++
Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1235
Query: 724 I-----------RELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSL 772
+ +E+E+ ++ + L+ + + + + + + + + +E + +
Sbjct: 1236 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1295
Query: 773 KIEAENKYDAIKFKINQLSELADPLKDELNLADSEVD---NQKRGKRHYEEKQKEHLDTL 829
EAE K AIK ++ L+ L+D L E N R EE++ D L
Sbjct: 1296 LNEAEGK--AIKL-AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL 1352
Query: 830 NKK-------KRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEH 882
+++ +R + +L + + + +E+ KEI L Q+ + +
Sbjct: 1353 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1412
Query: 883 ASHGDREEIM-RQYQEARETYLDLDSKVRTL-------KKFIKLLGE 921
A++ E+ R QE + +DLD++ + + +KF +LL E
Sbjct: 1413 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1459
Score = 45.4 bits (106), Expect = 3e-04
Identities = 58/286 (20%), Positives = 125/286 (43%), Gaps = 21/286 (7%)
Query: 662 RDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNE----ELLKRCQLHYKELKMKI 717
R + ++ + E E+E++ Q LE D+K E +K + K+L+ K+
Sbjct: 1592 RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR-KL 1650
Query: 718 RKNISEI-RELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEA 776
+ + + RELE+ + AT A+EN+ K K +E + Q +E++ + + +A
Sbjct: 1651 QAQMKDFQRELEDARASRDEIFAT----AKENEKKAKSLEADLMQLQEDLAAAERARKQA 1706
Query: 777 ENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKREL 836
+ + + + ++ + L+DE ++ + + + + D + K ++
Sbjct: 1707 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1766
Query: 837 DMKEKELEEKMSQARQICPERIEVEKSASILDKEI--------NRLRQKIQAEHASHGDR 888
+ EL + S A++ R ++E+ L ++ ++ + I A A
Sbjct: 1767 EQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1826
Query: 889 EEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFR 934
EE + QEARE S + KK ++L ++ + R K +Q++
Sbjct: 1827 EEQVE--QEAREKQAATKSLKQKDKKLKEILLQVEDER-KMAEQYK 1869
Score = 39.3 bits (90), Expect = 0.021
Identities = 44/172 (25%), Positives = 76/172 (44%), Gaps = 13/172 (7%)
Query: 215 QLE-QMKEDYSYIME----TKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKT 269
QLE Q KE S + E K + K I E ++ +L+ Q VE+E R + A ++K
Sbjct: 1789 QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ-VEQEAR-EKQAATKSLKQ 1846
Query: 270 NLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQ 329
+ LK + V + K ++ + G R +L R++EE + + +Q
Sbjct: 1847 KDKKLKEILLQ--VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQ 1904
Query: 330 DKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDD 381
+L++ +E A E ALK +K R NE + +R + ++ D
Sbjct: 1905 RELDEATESNEAMGREVNALK----SKLRRGNETSFVPSRRSGGRRVIENAD 1952
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 89.0 bits (219), Expect = 2e-17
Identities = 146/735 (19%), Positives = 297/735 (40%), Gaps = 104/735 (14%)
Query: 199 QSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERF 258
Q+K E + K ++A Q+++++ S + +++H+ + + + E E +
Sbjct: 1252 QAKQEVEHKKKKLEA-QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310
Query: 259 ----QSIAGLSTMKTNLESLKHEMAWAVVN------EIEKQLNAIRDNIKIGEDRAARLD 308
+ +A LS+ + + L E +N ++E++ N+++D + + L+
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370
Query: 309 RKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYN 368
R + ++L+++++K +D +E + E E L K AY++ E N
Sbjct: 1371 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1430
Query: 369 RSLNEYKALKKD---DEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQEN 425
R E L D QL +E+ ++ DQ L E+ K + ++R +A ++
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK-NISSKYADERDRAEAEAREKE 1489
Query: 426 ----SVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFG 481
S+ + +E+ +A E+ + + +K E D+ + + + EL+ SK L+
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR-ALETQM 1548
Query: 482 PNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIE-SCLKGL----LQAYCC 536
+ LE ++D + D +L L + LKG LQA
Sbjct: 1549 EEMKTQLEELEDELQA----------------TEDAKLRLEVNMQALKGQFERDLQARDE 1592
Query: 537 HNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNA 596
N R LQ + E+ E+ D R + A L D
Sbjct: 1593 QNEEKRRQLQRQLH---------------EYETELEDERKQRALAAAAKKKLEGDLKDLE 1637
Query: 597 VVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTR 656
+ A+S I +G E + R + K + E A D++FA +
Sbjct: 1638 LQADSAI--KGREEAI-----KQLRKLQAQMKDFQRELEDARASRDEIFATA--KENEKK 1688
Query: 657 PKFLSRDV-----------------DSEISDLENEVENKTAQILNLQQHLSALEKDIKHN 699
K L D+ D E +L E+ + + LQ LE I
Sbjct: 1689 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1748
Query: 700 EELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHM 759
EE L+ Q + + + ++RK + +L N ++AT AQ+N+S + +E
Sbjct: 1749 EEELEEEQGNMEAMSDRVRKATQQAEQLSN-------ELATERSTAQKNESARQQLERQN 1801
Query: 760 EQQKENMEHLK-SLKIEAENKYDAIKFKINQLSELADPLKDELNLADS------------ 806
++ + + ++ ++K + ++ A++ KI QL E + E A
Sbjct: 1802 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1861
Query: 807 --EVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSA 864
+V+++++ Y+E+ ++ + + KR+L+ E+E + + R++ E E +S
Sbjct: 1862 LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESN 1921
Query: 865 SILDKEINRLRQKIQ 879
+ +E+N L+ K++
Sbjct: 1922 EAMGREVNALKSKLR 1936
Score = 82.0 bits (201), Expect = 3e-15
Identities = 147/745 (19%), Positives = 329/745 (44%), Gaps = 69/745 (9%)
Query: 215 QLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESL 274
Q+ + +E+ + ++TKE+ + E L EL+++ + E + +T L +
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 275 KHEMAWAVV---NEIEKQLNAIRDNIKIGEDRAARLD---RKMEEQQVRLNEAEQKYKDI 328
EM + E+E+ L+ + ++ EDR +L +KM +Q + L E ++ +
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 329 QDKL--EKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCK 386
+ KL EK++ E + E L D K + E ++L R +++ ++E+ K
Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS-KERKLLEER-ISDLTTNLAEEEEKAK 1030
Query: 387 RIEELKKSTDQSLEP--ERLERQKKISWLKERVKA-FQNQENSVNQEIEQFQQAIEKDKE 443
+ +LK + + RL++++K E++K + + +++I Q I + K
Sbjct: 1031 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1090
Query: 444 EHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYK 503
+ K K EEL AL+ ++ + K++ +++ ++ L E +D + K
Sbjct: 1091 QLAK-KEEELQA--ALARLDDEIAQ-KNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1146
Query: 504 PVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPII 563
LG + EL ++S A ++ L+A ++ T +
Sbjct: 1147 QKRDLGEELEALKTELEDTLDST-------------ATQQELRAKREQEV---TVLKKAL 1190
Query: 564 VSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVA--- 620
E R+ V+ H LT +++ A + +D + L +N +A
Sbjct: 1191 DEETRSHEAQVQEMRQKHAQAVEELTE-QLEQFKRAKANLDKN--KQTLEKENADLAGEL 1247
Query: 621 RAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTA 680
R + Q+++ ++ ++ A QV + S+ R + +++ ++ L+NEVE+ T
Sbjct: 1248 RVLGQAKQEVEHKKKKLEA---QVQELQSKCSDGERAR---AELNDKVHKLQNEVESVTG 1301
Query: 681 QI-------LNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIREL-----E 728
+ + L + +++L ++ +ELL+ + K+R+ E L E
Sbjct: 1302 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE 1361
Query: 729 NIEEHQSVD--IATLEDEAQENKSKMK----MVEEHMEQQKENMEHLKSLKIEAENK--- 779
+E Q+++ I+TL + ++K K++ VE E +K + +++L + E K
Sbjct: 1362 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1421
Query: 780 YDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMK 839
YD ++ N+L + D L +L+ V N ++ +R +++ E + +K E D
Sbjct: 1422 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1481
Query: 840 EKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEAR 899
E E EK ++A + E ++ L++ L+ +++ +S ++++ + E
Sbjct: 1482 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS---KDDVGKNVHELE 1538
Query: 900 ETYLDLDSKVRTLKKFIKLLGEIME 924
++ L++++ +K ++ L + ++
Sbjct: 1539 KSKRALETQMEEMKTQLEELEDELQ 1563
Score = 76.6 bits (187), Expect = 1e-13
Identities = 160/861 (18%), Positives = 355/861 (41%), Gaps = 100/861 (11%)
Query: 186 VSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLT 245
+ V QE Q + + + K + +L+++++ +S + E K +EQ+ Q E T
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL-QAE---T 907
Query: 246 ELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEK--QLNAIRDNI------ 297
EL + E R L+ K LE + HEM + E ++ QL A R +
Sbjct: 908 ELYAEAEEMRVR------LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 961
Query: 298 ---KIGEDRAARLDRKMEE--QQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKAD 352
++ E+ AAR ++E+ + ++ + E + + D+ K+S+E L +
Sbjct: 962 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021
Query: 353 VVAKKRAYNEAEVLYNRS---LNEYKALKKDDEQLCKRIEELKKSTD---QSLEPERLER 406
+ ++ L N+ ++E + K +E+ + +E+LK+ + + +
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1081
Query: 407 QKKISWLKERVKAFQNQENS----VNQEIEQFQQAIEKDKEEHGKIK--REELDVKHALS 460
Q +I+ LK ++ + + + ++ EI Q A++K +E G I +E+LD + A
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141
Query: 461 YNQRQLK-----ELKDSKTD--------------RLKRFGPNVPALLEAIDDAYRQGHFT 501
+ K EL+ KT+ R KR V L +A+D+ R
Sbjct: 1142 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR-EQEVTVLKKALDEETRSHE-- 1198
Query: 502 YKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPP 561
A + + A A+E + L Q + D+ + L G R
Sbjct: 1199 --------AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR-- 1248
Query: 562 IIVSEFRNEIYDVRHRA-AYHPDFPTVLTALEIDNAVVANSLIDMRG-IETVLLIKNNSV 619
++ + + E+ + + A + + + E A + + + ++ +E+V + N +
Sbjct: 1249 -VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1307
Query: 620 ARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKT 679
+A+ ++ + D ++ N K R ++ E + L+++++ +
Sbjct: 1308 GKAIKLAKDVASLSSQL--QDTQELLQEETRQKLNVSTKL--RQLEEERNSLQDQLDEEM 1363
Query: 680 AQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIA 739
NL++H+S L + +++ L+ + L+ + +K +E+EN+ + Q + A
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE-EGKKRFQ--KEIENLTQ-QYEEKA 1419
Query: 740 TLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSELADPLKD 799
D+ ++ K++++ + + +N L S + + K+D + + + ++ D
Sbjct: 1420 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL---LAEEKNISSKYAD 1476
Query: 800 ELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIE 859
E + A++E ++ +E L+ + +R M + E+E+ +S + E
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536
Query: 860 VEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLL 919
+EKS L+ ++ ++ ++ EE+ + Q + L L+ ++ LK +
Sbjct: 1537 LEKSKRALETQMEEMKTQL----------EELEDELQATEDAKLRLEVNMQALKGQFE-- 1584
Query: 920 GEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQR-----AYCGKMNFDHKNETLSISVQPG 974
++ R + ++ RR L + Y L +R A K + + L +
Sbjct: 1585 -RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1643
Query: 975 -EGNKAAFNDMRALSGGERSF 994
+G + A +R L + F
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDF 1664
Score = 71.2 bits (173), Expect = 5e-12
Identities = 151/817 (18%), Positives = 332/817 (40%), Gaps = 87/817 (10%)
Query: 155 KLKSATGSVVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKA- 213
+L+ T + E+ I ++D N ++ +L + +S E +K K K
Sbjct: 977 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036
Query: 214 TQLEQMKEDYSYIMETKERTK------------------EQIHQGEERLTELKRQCVEKE 255
+ E M + ++ +E+++ EQI + ++ ELK Q +KE
Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096
Query: 256 ERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQ 315
E Q+ + + + E + A + E+E ++ ++++ + +RAAR K E+Q+
Sbjct: 1097 EELQA----ALARLDDEIAQKNNALKKIRELEGHISDLQED--LDSERAAR--NKAEKQK 1148
Query: 316 VRLNEAEQKYK-DIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEY 374
L E + K +++D L+ + + RA + +V K+A +E + + E
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKR----EQEVTVLKKALDEETRSHEAQVQEM 1204
Query: 375 KALKKDD-EQLCKRIEELKKS------TDQSLEPERLERQKKISWLKERVKAFQNQENSV 427
+ E+L +++E+ K++ Q+LE E + ++ L + + ++++ +
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 428 NQEIEQFQQAIEKDKEEHGKIKREELDVK-HALSYNQRQLKELKDSKTDRLKRFGPNVPA 486
++++ Q K G+ R EL+ K H L + + + + + +V +
Sbjct: 1265 EAQVQELQ-----SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 487 LLEAIDDAYRQGHFTYKPVGPLGACIHLRD-PELALAIESCLKGLLQA-YCCHNHADERV 544
L + D Q + L LR E +++ L ++A H
Sbjct: 1320 LSSQLQDT--QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1377
Query: 545 LQALMKRFYLPGTSRPPIIVSE----FRNEIYDV----RHRAAYHPDFPTVLTAL--EID 594
+Q + L + + E F+ EI ++ +AA + L E+D
Sbjct: 1378 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1437
Query: 595 NAVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSEN 654
+ VV L + R + + L K + + + KN + + D+ A +
Sbjct: 1438 DLVV--DLDNQRQLVSNLEKKQRKFDQLLAEE----KNISSKYADERDRAEAEA--REKE 1489
Query: 655 TRPKFLSRDVDSEI---SDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYK 711
T+ L+R ++ + +LE + A++ +L + K++ E+ + + +
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549
Query: 712 ELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKS 771
E+K ++ + E++ E+ + V++ L+ + + + E +Q + H
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609
Query: 772 LKIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNK 831
++E E K A+ + +L LKD ADS + + ++E + L K
Sbjct: 1610 TELEDERKQRALAAAAKK--KLEGDLKDLELQADSAI-----------KGREEAIKQLRK 1656
Query: 832 KKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHG----D 887
+ ++ ++ELE+ + +I E EK A L+ ++ +L++ + A + +
Sbjct: 1657 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1716
Query: 888 REEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIME 924
+EE+ + + L + R L+ I L E +E
Sbjct: 1717 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1753
Score = 63.2 bits (152), Expect = 1e-09
Identities = 132/707 (18%), Positives = 292/707 (41%), Gaps = 96/707 (13%)
Query: 256 ERFQSIAGLSTMKTNLES---LKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKME 312
+R Q + + ++ N + L++ W + +++ L R E+ A+ D +++
Sbjct: 815 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQE----EEMQAKED-ELQ 869
Query: 313 EQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLN 372
+ + R +AE + K+++ K +++EE N L+ + A+ Y EAE + R
Sbjct: 870 KTKERQQKAENELKELEQKHSQLTEEKNL-------LQEQLQAETELYAEAEEMRVRLAA 922
Query: 373 EYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIE 432
+ + L++ ++ R+EE ++ Q L+ ER + +++ L+E+++ +E + Q+++
Sbjct: 923 KKQELEEILHEMEARLEE-EEDRGQQLQAERKKMAQQMLDLEEQLE----EEEAARQKLQ 977
Query: 433 QFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAID 492
+EK E KIK+ E ++ N + KE K +R+ N+ E
Sbjct: 978 -----LEKVTAE-AKIKKLEDEILVMDDQNNKLSKERK-LLEERISDLTTNLAEEEEKAK 1030
Query: 493 DAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRF 552
+ + + + L + L+ E + LK L+ H LQA
Sbjct: 1031 NLTKLKNKHESMISELE--VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ---- 1084
Query: 553 YLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVL 612
++E + ++ A + L L+ + A N+L +R +E +
Sbjct: 1085 -----------IAELKMQL------AKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1127
Query: 613 LIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENT-----RPKFLSRDVDSE 667
S + + S++ +N E D + E+T + L + E
Sbjct: 1128 -----SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE 1182
Query: 668 ISDLENEVENKT----AQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISE 723
++ L+ ++ +T AQ+ ++Q + +++ E KR + + + K + K ++
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1242
Query: 724 I-----------RELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSL 772
+ +E+E+ ++ + L+ + + + + + + + + +E + +
Sbjct: 1243 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1302
Query: 773 KIEAENKYDAIKFKINQLSELADPLKDELNLADSEVD---NQKRGKRHYEEKQKEHLDTL 829
EAE K AIK ++ L+ L+D L E N R EE++ D L
Sbjct: 1303 LNEAEGK--AIKL-AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL 1359
Query: 830 NKK-------KRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEH 882
+++ +R + +L + + + +E+ KEI L Q+ + +
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1419
Query: 883 ASHGDREEIM-RQYQEARETYLDLDSKVRTL-------KKFIKLLGE 921
A++ E+ R QE + +DLD++ + + +KF +LL E
Sbjct: 1420 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466
Score = 45.4 bits (106), Expect = 3e-04
Identities = 58/286 (20%), Positives = 125/286 (43%), Gaps = 21/286 (7%)
Query: 662 RDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNE----ELLKRCQLHYKELKMKI 717
R + ++ + E E+E++ Q LE D+K E +K + K+L+ K+
Sbjct: 1599 RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR-KL 1657
Query: 718 RKNISEI-RELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEA 776
+ + + RELE+ + AT A+EN+ K K +E + Q +E++ + + +A
Sbjct: 1658 QAQMKDFQRELEDARASRDEIFAT----AKENEKKAKSLEADLMQLQEDLAAAERARKQA 1713
Query: 777 ENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKREL 836
+ + + + ++ + L+DE ++ + + + + D + K ++
Sbjct: 1714 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1773
Query: 837 DMKEKELEEKMSQARQICPERIEVEKSASILDKEI--------NRLRQKIQAEHASHGDR 888
+ EL + S A++ R ++E+ L ++ ++ + I A A
Sbjct: 1774 EQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1833
Query: 889 EEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFR 934
EE + QEARE S + KK ++L ++ + R K +Q++
Sbjct: 1834 EEQVE--QEAREKQAATKSLKQKDKKLKEILLQVEDER-KMAEQYK 1876
Score = 39.3 bits (90), Expect = 0.021
Identities = 44/172 (25%), Positives = 76/172 (44%), Gaps = 13/172 (7%)
Query: 215 QLE-QMKEDYSYIME----TKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKT 269
QLE Q KE S + E K + K I E ++ +L+ Q VE+E R + A ++K
Sbjct: 1796 QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ-VEQEAR-EKQAATKSLKQ 1853
Query: 270 NLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQ 329
+ LK + V + K ++ + G R +L R++EE + + +Q
Sbjct: 1854 KDKKLKEILLQ--VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQ 1911
Query: 330 DKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDD 381
+L++ +E A E ALK +K R NE + +R + ++ D
Sbjct: 1912 RELDEATESNEAMGREVNALK----SKLRRGNETSFVPSRRSGGRRVIENAD 1959
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 89.0 bits (219), Expect = 2e-17
Identities = 146/735 (19%), Positives = 297/735 (40%), Gaps = 104/735 (14%)
Query: 199 QSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERF 258
Q+K E + K ++A Q+++++ S + +++H+ + + + E E +
Sbjct: 1252 QAKQEVEHKKKKLEA-QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310
Query: 259 ----QSIAGLSTMKTNLESLKHEMAWAVVN------EIEKQLNAIRDNIKIGEDRAARLD 308
+ +A LS+ + + L E +N ++E++ N+++D + + L+
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370
Query: 309 RKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYN 368
R + ++L+++++K +D +E + E E L K AY++ E N
Sbjct: 1371 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1430
Query: 369 RSLNEYKALKKD---DEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQEN 425
R E L D QL +E+ ++ DQ L E+ K + ++R +A ++
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK-NISSKYADERDRAEAEAREKE 1489
Query: 426 ----SVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFG 481
S+ + +E+ +A E+ + + +K E D+ + + + EL+ SK L+
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR-ALETQM 1548
Query: 482 PNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIE-SCLKGL----LQAYCC 536
+ LE ++D + D +L L + LKG LQA
Sbjct: 1549 EEMKTQLEELEDELQA----------------TEDAKLRLEVNMQALKGQFERDLQARDE 1592
Query: 537 HNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNA 596
N R LQ + E+ E+ D R + A L D
Sbjct: 1593 QNEEKRRQLQRQLH---------------EYETELEDERKQRALAAAAKKKLEGDLKDLE 1637
Query: 597 VVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTR 656
+ A+S I +G E + R + K + E A D++FA +
Sbjct: 1638 LQADSAI--KGREEAI-----KQLRKLQAQMKDFQRELEDARASRDEIFATA--KENEKK 1688
Query: 657 PKFLSRDV-----------------DSEISDLENEVENKTAQILNLQQHLSALEKDIKHN 699
K L D+ D E +L E+ + + LQ LE I
Sbjct: 1689 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1748
Query: 700 EELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHM 759
EE L+ Q + + + ++RK + +L N ++AT AQ+N+S + +E
Sbjct: 1749 EEELEEEQGNMEAMSDRVRKATQQAEQLSN-------ELATERSTAQKNESARQQLERQN 1801
Query: 760 EQQKENMEHLK-SLKIEAENKYDAIKFKINQLSELADPLKDELNLADS------------ 806
++ + + ++ ++K + ++ A++ KI QL E + E A
Sbjct: 1802 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1861
Query: 807 --EVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSA 864
+V+++++ Y+E+ ++ + + KR+L+ E+E + + R++ E E +S
Sbjct: 1862 LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESN 1921
Query: 865 SILDKEINRLRQKIQ 879
+ +E+N L+ K++
Sbjct: 1922 EAMGREVNALKSKLR 1936
Score = 82.0 bits (201), Expect = 3e-15
Identities = 147/745 (19%), Positives = 329/745 (44%), Gaps = 69/745 (9%)
Query: 215 QLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESL 274
Q+ + +E+ + ++TKE+ + E L EL+++ + E + +T L +
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 275 KHEMAWAVV---NEIEKQLNAIRDNIKIGEDRAARLD---RKMEEQQVRLNEAEQKYKDI 328
EM + E+E+ L+ + ++ EDR +L +KM +Q + L E ++ +
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 329 QDKL--EKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCK 386
+ KL EK++ E + E L D K + E ++L R +++ ++E+ K
Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS-KERKLLEER-ISDLTTNLAEEEEKAK 1030
Query: 387 RIEELKKSTDQSLEP--ERLERQKKISWLKERVKA-FQNQENSVNQEIEQFQQAIEKDKE 443
+ +LK + + RL++++K E++K + + +++I Q I + K
Sbjct: 1031 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1090
Query: 444 EHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYK 503
+ K K EEL AL+ ++ + K++ +++ ++ L E +D + K
Sbjct: 1091 QLAK-KEEELQA--ALARLDDEIAQ-KNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1146
Query: 504 PVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPII 563
LG + EL ++S A ++ L+A ++ T +
Sbjct: 1147 QKRDLGEELEALKTELEDTLDST-------------ATQQELRAKREQEV---TVLKKAL 1190
Query: 564 VSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVA--- 620
E R+ V+ H LT +++ A + +D + L +N +A
Sbjct: 1191 DEETRSHEAQVQEMRQKHAQAVEELTE-QLEQFKRAKANLDKN--KQTLEKENADLAGEL 1247
Query: 621 RAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTA 680
R + Q+++ ++ ++ A QV + S+ R + +++ ++ L+NEVE+ T
Sbjct: 1248 RVLGQAKQEVEHKKKKLEA---QVQELQSKCSDGERAR---AELNDKVHKLQNEVESVTG 1301
Query: 681 QI-------LNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIREL-----E 728
+ + L + +++L ++ +ELL+ + K+R+ E L E
Sbjct: 1302 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE 1361
Query: 729 NIEEHQSVD--IATLEDEAQENKSKMK----MVEEHMEQQKENMEHLKSLKIEAENK--- 779
+E Q+++ I+TL + ++K K++ VE E +K + +++L + E K
Sbjct: 1362 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1421
Query: 780 YDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMK 839
YD ++ N+L + D L +L+ V N ++ +R +++ E + +K E D
Sbjct: 1422 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1481
Query: 840 EKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEAR 899
E E EK ++A + E ++ L++ L+ +++ +S ++++ + E
Sbjct: 1482 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS---KDDVGKNVHELE 1538
Query: 900 ETYLDLDSKVRTLKKFIKLLGEIME 924
++ L++++ +K ++ L + ++
Sbjct: 1539 KSKRALETQMEEMKTQLEELEDELQ 1563
Score = 76.6 bits (187), Expect = 1e-13
Identities = 160/861 (18%), Positives = 355/861 (41%), Gaps = 100/861 (11%)
Query: 186 VSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLT 245
+ V QE Q + + + K + +L+++++ +S + E K +EQ+ Q E T
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL-QAE---T 907
Query: 246 ELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEK--QLNAIRDNI------ 297
EL + E R L+ K LE + HEM + E ++ QL A R +
Sbjct: 908 ELYAEAEEMRVR------LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 961
Query: 298 ---KIGEDRAARLDRKMEE--QQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKAD 352
++ E+ AAR ++E+ + ++ + E + + D+ K+S+E L +
Sbjct: 962 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021
Query: 353 VVAKKRAYNEAEVLYNRS---LNEYKALKKDDEQLCKRIEELKKSTD---QSLEPERLER 406
+ ++ L N+ ++E + K +E+ + +E+LK+ + + +
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1081
Query: 407 QKKISWLKERVKAFQNQENS----VNQEIEQFQQAIEKDKEEHGKIK--REELDVKHALS 460
Q +I+ LK ++ + + + ++ EI Q A++K +E G I +E+LD + A
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141
Query: 461 YNQRQLK-----ELKDSKTD--------------RLKRFGPNVPALLEAIDDAYRQGHFT 501
+ K EL+ KT+ R KR V L +A+D+ R
Sbjct: 1142 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR-EQEVTVLKKALDEETRSHE-- 1198
Query: 502 YKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPP 561
A + + A A+E + L Q + D+ + L G R
Sbjct: 1199 --------AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR-- 1248
Query: 562 IIVSEFRNEIYDVRHRA-AYHPDFPTVLTALEIDNAVVANSLIDMRG-IETVLLIKNNSV 619
++ + + E+ + + A + + + E A + + + ++ +E+V + N +
Sbjct: 1249 -VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1307
Query: 620 ARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKT 679
+A+ ++ + D ++ N K R ++ E + L+++++ +
Sbjct: 1308 GKAIKLAKDVASLSSQL--QDTQELLQEETRQKLNVSTKL--RQLEEERNSLQDQLDEEM 1363
Query: 680 AQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIA 739
NL++H+S L + +++ L+ + L+ + +K +E+EN+ + Q + A
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE-EGKKRFQ--KEIENLTQ-QYEEKA 1419
Query: 740 TLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSELADPLKD 799
D+ ++ K++++ + + +N L S + + K+D + + + ++ D
Sbjct: 1420 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL---LAEEKNISSKYAD 1476
Query: 800 ELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIE 859
E + A++E ++ +E L+ + +R M + E+E+ +S + E
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536
Query: 860 VEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLL 919
+EKS L+ ++ ++ ++ EE+ + Q + L L+ ++ LK +
Sbjct: 1537 LEKSKRALETQMEEMKTQL----------EELEDELQATEDAKLRLEVNMQALKGQFE-- 1584
Query: 920 GEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQR-----AYCGKMNFDHKNETLSISVQPG 974
++ R + ++ RR L + Y L +R A K + + L +
Sbjct: 1585 -RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1643
Query: 975 -EGNKAAFNDMRALSGGERSF 994
+G + A +R L + F
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDF 1664
Score = 71.2 bits (173), Expect = 5e-12
Identities = 151/817 (18%), Positives = 332/817 (40%), Gaps = 87/817 (10%)
Query: 155 KLKSATGSVVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKA- 213
+L+ T + E+ I ++D N ++ +L + +S E +K K K
Sbjct: 977 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036
Query: 214 TQLEQMKEDYSYIMETKERTK------------------EQIHQGEERLTELKRQCVEKE 255
+ E M + ++ +E+++ EQI + ++ ELK Q +KE
Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096
Query: 256 ERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQ 315
E Q+ + + + E + A + E+E ++ ++++ + +RAAR K E+Q+
Sbjct: 1097 EELQA----ALARLDDEIAQKNNALKKIRELEGHISDLQED--LDSERAAR--NKAEKQK 1148
Query: 316 VRLNEAEQKYK-DIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEY 374
L E + K +++D L+ + + RA + +V K+A +E + + E
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKR----EQEVTVLKKALDEETRSHEAQVQEM 1204
Query: 375 KALKKDD-EQLCKRIEELKKS------TDQSLEPERLERQKKISWLKERVKAFQNQENSV 427
+ E+L +++E+ K++ Q+LE E + ++ L + + ++++ +
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 428 NQEIEQFQQAIEKDKEEHGKIKREELDVK-HALSYNQRQLKELKDSKTDRLKRFGPNVPA 486
++++ Q K G+ R EL+ K H L + + + + + +V +
Sbjct: 1265 EAQVQELQ-----SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 487 LLEAIDDAYRQGHFTYKPVGPLGACIHLRD-PELALAIESCLKGLLQA-YCCHNHADERV 544
L + D Q + L LR E +++ L ++A H
Sbjct: 1320 LSSQLQDT--QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1377
Query: 545 LQALMKRFYLPGTSRPPIIVSE----FRNEIYDV----RHRAAYHPDFPTVLTAL--EID 594
+Q + L + + E F+ EI ++ +AA + L E+D
Sbjct: 1378 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1437
Query: 595 NAVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSEN 654
+ VV L + R + + L K + + + KN + + D+ A +
Sbjct: 1438 DLVV--DLDNQRQLVSNLEKKQRKFDQLLAEE----KNISSKYADERDRAEAEA--REKE 1489
Query: 655 TRPKFLSRDVDSEI---SDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYK 711
T+ L+R ++ + +LE + A++ +L + K++ E+ + + +
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549
Query: 712 ELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKS 771
E+K ++ + E++ E+ + V++ L+ + + + E +Q + H
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609
Query: 772 LKIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNK 831
++E E K A+ + +L LKD ADS + + ++E + L K
Sbjct: 1610 TELEDERKQRALAAAAKK--KLEGDLKDLELQADSAI-----------KGREEAIKQLRK 1656
Query: 832 KKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHG----D 887
+ ++ ++ELE+ + +I E EK A L+ ++ +L++ + A + +
Sbjct: 1657 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1716
Query: 888 REEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIME 924
+EE+ + + L + R L+ I L E +E
Sbjct: 1717 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1753
Score = 63.2 bits (152), Expect = 1e-09
Identities = 132/707 (18%), Positives = 292/707 (41%), Gaps = 96/707 (13%)
Query: 256 ERFQSIAGLSTMKTNLES---LKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKME 312
+R Q + + ++ N + L++ W + +++ L R E+ A+ D +++
Sbjct: 815 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQE----EEMQAKED-ELQ 869
Query: 313 EQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLN 372
+ + R +AE + K+++ K +++EE N L+ + A+ Y EAE + R
Sbjct: 870 KTKERQQKAENELKELEQKHSQLTEEKNL-------LQEQLQAETELYAEAEEMRVRLAA 922
Query: 373 EYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIE 432
+ + L++ ++ R+EE ++ Q L+ ER + +++ L+E+++ +E + Q+++
Sbjct: 923 KKQELEEILHEMEARLEE-EEDRGQQLQAERKKMAQQMLDLEEQLE----EEEAARQKLQ 977
Query: 433 QFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAID 492
+EK E KIK+ E ++ N + KE K +R+ N+ E
Sbjct: 978 -----LEKVTAE-AKIKKLEDEILVMDDQNNKLSKERK-LLEERISDLTTNLAEEEEKAK 1030
Query: 493 DAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRF 552
+ + + + L + L+ E + LK L+ H LQA
Sbjct: 1031 NLTKLKNKHESMISELE--VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ---- 1084
Query: 553 YLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVL 612
++E + ++ A + L L+ + A N+L +R +E +
Sbjct: 1085 -----------IAELKMQL------AKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1127
Query: 613 LIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENT-----RPKFLSRDVDSE 667
S + + S++ +N E D + E+T + L + E
Sbjct: 1128 -----SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE 1182
Query: 668 ISDLENEVENKT----AQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISE 723
++ L+ ++ +T AQ+ ++Q + +++ E KR + + + K + K ++
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1242
Query: 724 I-----------RELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSL 772
+ +E+E+ ++ + L+ + + + + + + + + +E + +
Sbjct: 1243 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1302
Query: 773 KIEAENKYDAIKFKINQLSELADPLKDELNLADSEVD---NQKRGKRHYEEKQKEHLDTL 829
EAE K AIK ++ L+ L+D L E N R EE++ D L
Sbjct: 1303 LNEAEGK--AIKL-AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL 1359
Query: 830 NKK-------KRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEH 882
+++ +R + +L + + + +E+ KEI L Q+ + +
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1419
Query: 883 ASHGDREEIM-RQYQEARETYLDLDSKVRTL-------KKFIKLLGE 921
A++ E+ R QE + +DLD++ + + +KF +LL E
Sbjct: 1420 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466
Score = 45.4 bits (106), Expect = 3e-04
Identities = 58/286 (20%), Positives = 125/286 (43%), Gaps = 21/286 (7%)
Query: 662 RDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNE----ELLKRCQLHYKELKMKI 717
R + ++ + E E+E++ Q LE D+K E +K + K+L+ K+
Sbjct: 1599 RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR-KL 1657
Query: 718 RKNISEI-RELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEA 776
+ + + RELE+ + AT A+EN+ K K +E + Q +E++ + + +A
Sbjct: 1658 QAQMKDFQRELEDARASRDEIFAT----AKENEKKAKSLEADLMQLQEDLAAAERARKQA 1713
Query: 777 ENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKREL 836
+ + + + ++ + L+DE ++ + + + + D + K ++
Sbjct: 1714 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1773
Query: 837 DMKEKELEEKMSQARQICPERIEVEKSASILDKEI--------NRLRQKIQAEHASHGDR 888
+ EL + S A++ R ++E+ L ++ ++ + I A A
Sbjct: 1774 EQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1833
Query: 889 EEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFR 934
EE + QEARE S + KK ++L ++ + R K +Q++
Sbjct: 1834 EEQVE--QEAREKQAATKSLKQKDKKLKEILLQVEDER-KMAEQYK 1876
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 89.0 bits (219), Expect = 2e-17
Identities = 146/735 (19%), Positives = 297/735 (40%), Gaps = 104/735 (14%)
Query: 199 QSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERF 258
Q+K E + K ++A Q+++++ S + +++H+ + + + E E +
Sbjct: 1245 QAKQEVEHKKKKLEA-QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303
Query: 259 ----QSIAGLSTMKTNLESLKHEMAWAVVN------EIEKQLNAIRDNIKIGEDRAARLD 308
+ +A LS+ + + L E +N ++E++ N+++D + + L+
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363
Query: 309 RKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYN 368
R + ++L+++++K +D +E + E E L K AY++ E N
Sbjct: 1364 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1423
Query: 369 RSLNEYKALKKD---DEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQEN 425
R E L D QL +E+ ++ DQ L E+ K + ++R +A ++
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK-NISSKYADERDRAEAEAREKE 1482
Query: 426 ----SVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFG 481
S+ + +E+ +A E+ + + +K E D+ + + + EL+ SK L+
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR-ALETQM 1541
Query: 482 PNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIE-SCLKGL----LQAYCC 536
+ LE ++D + D +L L + LKG LQA
Sbjct: 1542 EEMKTQLEELEDELQA----------------TEDAKLRLEVNMQALKGQFERDLQARDE 1585
Query: 537 HNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNA 596
N R LQ + E+ E+ D R + A L D
Sbjct: 1586 QNEEKRRQLQRQLH---------------EYETELEDERKQRALAAAAKKKLEGDLKDLE 1630
Query: 597 VVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTR 656
+ A+S I +G E + R + K + E A D++FA +
Sbjct: 1631 LQADSAI--KGREEAI-----KQLRKLQAQMKDFQRELEDARASRDEIFATA--KENEKK 1681
Query: 657 PKFLSRDV-----------------DSEISDLENEVENKTAQILNLQQHLSALEKDIKHN 699
K L D+ D E +L E+ + + LQ LE I
Sbjct: 1682 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1741
Query: 700 EELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHM 759
EE L+ Q + + + ++RK + +L N ++AT AQ+N+S + +E
Sbjct: 1742 EEELEEEQGNMEAMSDRVRKATQQAEQLSN-------ELATERSTAQKNESARQQLERQN 1794
Query: 760 EQQKENMEHLK-SLKIEAENKYDAIKFKINQLSELADPLKDELNLADS------------ 806
++ + + ++ ++K + ++ A++ KI QL E + E A
Sbjct: 1795 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1854
Query: 807 --EVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSA 864
+V+++++ Y+E+ ++ + + KR+L+ E+E + + R++ E E +S
Sbjct: 1855 LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESN 1914
Query: 865 SILDKEINRLRQKIQ 879
+ +E+N L+ K++
Sbjct: 1915 EAMGREVNALKSKLR 1929
Score = 82.0 bits (201), Expect = 3e-15
Identities = 147/745 (19%), Positives = 329/745 (44%), Gaps = 69/745 (9%)
Query: 215 QLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESL 274
Q+ + +E+ + ++TKE+ + E L EL+++ + E + +T L +
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 275 KHEMAWAVV---NEIEKQLNAIRDNIKIGEDRAARLD---RKMEEQQVRLNEAEQKYKDI 328
EM + E+E+ L+ + ++ EDR +L +KM +Q + L E ++ +
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 329 QDKL--EKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCK 386
+ KL EK++ E + E L D K + E ++L R +++ ++E+ K
Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS-KERKLLEER-ISDLTTNLAEEEEKAK 1023
Query: 387 RIEELKKSTDQSLEP--ERLERQKKISWLKERVKA-FQNQENSVNQEIEQFQQAIEKDKE 443
+ +LK + + RL++++K E++K + + +++I Q I + K
Sbjct: 1024 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1083
Query: 444 EHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYK 503
+ K K EEL AL+ ++ + K++ +++ ++ L E +D + K
Sbjct: 1084 QLAK-KEEELQA--ALARLDDEIAQ-KNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1139
Query: 504 PVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPII 563
LG + EL ++S A ++ L+A ++ T +
Sbjct: 1140 QKRDLGEELEALKTELEDTLDST-------------ATQQELRAKREQEV---TVLKKAL 1183
Query: 564 VSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVA--- 620
E R+ V+ H LT +++ A + +D + L +N +A
Sbjct: 1184 DEETRSHEAQVQEMRQKHAQAVEELTE-QLEQFKRAKANLDKN--KQTLEKENADLAGEL 1240
Query: 621 RAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTA 680
R + Q+++ ++ ++ A QV + S+ R + +++ ++ L+NEVE+ T
Sbjct: 1241 RVLGQAKQEVEHKKKKLEA---QVQELQSKCSDGERAR---AELNDKVHKLQNEVESVTG 1294
Query: 681 QI-------LNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIREL-----E 728
+ + L + +++L ++ +ELL+ + K+R+ E L E
Sbjct: 1295 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE 1354
Query: 729 NIEEHQSVD--IATLEDEAQENKSKMK----MVEEHMEQQKENMEHLKSLKIEAENK--- 779
+E Q+++ I+TL + ++K K++ VE E +K + +++L + E K
Sbjct: 1355 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1414
Query: 780 YDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMK 839
YD ++ N+L + D L +L+ V N ++ +R +++ E + +K E D
Sbjct: 1415 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1474
Query: 840 EKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEAR 899
E E EK ++A + E ++ L++ L+ +++ +S ++++ + E
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS---KDDVGKNVHELE 1531
Query: 900 ETYLDLDSKVRTLKKFIKLLGEIME 924
++ L++++ +K ++ L + ++
Sbjct: 1532 KSKRALETQMEEMKTQLEELEDELQ 1556
Score = 76.6 bits (187), Expect = 1e-13
Identities = 160/861 (18%), Positives = 355/861 (41%), Gaps = 100/861 (11%)
Query: 186 VSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLT 245
+ V QE Q + + + K + +L+++++ +S + E K +EQ+ Q E T
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL-QAE---T 900
Query: 246 ELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEK--QLNAIRDNI------ 297
EL + E R L+ K LE + HEM + E ++ QL A R +
Sbjct: 901 ELYAEAEEMRVR------LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 954
Query: 298 ---KIGEDRAARLDRKMEE--QQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKAD 352
++ E+ AAR ++E+ + ++ + E + + D+ K+S+E L +
Sbjct: 955 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014
Query: 353 VVAKKRAYNEAEVLYNRS---LNEYKALKKDDEQLCKRIEELKKSTD---QSLEPERLER 406
+ ++ L N+ ++E + K +E+ + +E+LK+ + + +
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1074
Query: 407 QKKISWLKERVKAFQNQENS----VNQEIEQFQQAIEKDKEEHGKIK--REELDVKHALS 460
Q +I+ LK ++ + + + ++ EI Q A++K +E G I +E+LD + A
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1134
Query: 461 YNQRQLK-----ELKDSKTD--------------RLKRFGPNVPALLEAIDDAYRQGHFT 501
+ K EL+ KT+ R KR V L +A+D+ R
Sbjct: 1135 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR-EQEVTVLKKALDEETRSHE-- 1191
Query: 502 YKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPP 561
A + + A A+E + L Q + D+ + L G R
Sbjct: 1192 --------AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR-- 1241
Query: 562 IIVSEFRNEIYDVRHRA-AYHPDFPTVLTALEIDNAVVANSLIDMRG-IETVLLIKNNSV 619
++ + + E+ + + A + + + E A + + + ++ +E+V + N +
Sbjct: 1242 -VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1300
Query: 620 ARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKT 679
+A+ ++ + D ++ N K R ++ E + L+++++ +
Sbjct: 1301 GKAIKLAKDVASLSSQL--QDTQELLQEETRQKLNVSTKL--RQLEEERNSLQDQLDEEM 1356
Query: 680 AQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIA 739
NL++H+S L + +++ L+ + L+ + +K +E+EN+ + Q + A
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE-EGKKRFQ--KEIENLTQ-QYEEKA 1412
Query: 740 TLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSELADPLKD 799
D+ ++ K++++ + + +N L S + + K+D + + + ++ D
Sbjct: 1413 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL---LAEEKNISSKYAD 1469
Query: 800 ELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIE 859
E + A++E ++ +E L+ + +R M + E+E+ +S + E
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529
Query: 860 VEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLL 919
+EKS L+ ++ ++ ++ EE+ + Q + L L+ ++ LK +
Sbjct: 1530 LEKSKRALETQMEEMKTQL----------EELEDELQATEDAKLRLEVNMQALKGQFE-- 1577
Query: 920 GEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQR-----AYCGKMNFDHKNETLSISVQPG 974
++ R + ++ RR L + Y L +R A K + + L +
Sbjct: 1578 -RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1636
Query: 975 -EGNKAAFNDMRALSGGERSF 994
+G + A +R L + F
Sbjct: 1637 IKGREEAIKQLRKLQAQMKDF 1657
Score = 71.2 bits (173), Expect = 5e-12
Identities = 151/817 (18%), Positives = 332/817 (40%), Gaps = 87/817 (10%)
Query: 155 KLKSATGSVVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKA- 213
+L+ T + E+ I ++D N ++ +L + +S E +K K K
Sbjct: 970 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1029
Query: 214 TQLEQMKEDYSYIMETKERTK------------------EQIHQGEERLTELKRQCVEKE 255
+ E M + ++ +E+++ EQI + ++ ELK Q +KE
Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089
Query: 256 ERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQ 315
E Q+ + + + E + A + E+E ++ ++++ + +RAAR K E+Q+
Sbjct: 1090 EELQA----ALARLDDEIAQKNNALKKIRELEGHISDLQED--LDSERAAR--NKAEKQK 1141
Query: 316 VRLNEAEQKYK-DIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEY 374
L E + K +++D L+ + + RA + +V K+A +E + + E
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKR----EQEVTVLKKALDEETRSHEAQVQEM 1197
Query: 375 KALKKDD-EQLCKRIEELKKS------TDQSLEPERLERQKKISWLKERVKAFQNQENSV 427
+ E+L +++E+ K++ Q+LE E + ++ L + + ++++ +
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 428 NQEIEQFQQAIEKDKEEHGKIKREELDVK-HALSYNQRQLKELKDSKTDRLKRFGPNVPA 486
++++ Q K G+ R EL+ K H L + + + + + +V +
Sbjct: 1258 EAQVQELQ-----SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312
Query: 487 LLEAIDDAYRQGHFTYKPVGPLGACIHLRD-PELALAIESCLKGLLQA-YCCHNHADERV 544
L + D Q + L LR E +++ L ++A H
Sbjct: 1313 LSSQLQDT--QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1370
Query: 545 LQALMKRFYLPGTSRPPIIVSE----FRNEIYDV----RHRAAYHPDFPTVLTAL--EID 594
+Q + L + + E F+ EI ++ +AA + L E+D
Sbjct: 1371 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1430
Query: 595 NAVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSEN 654
+ VV L + R + + L K + + + KN + + D+ A +
Sbjct: 1431 DLVV--DLDNQRQLVSNLEKKQRKFDQLLAEE----KNISSKYADERDRAEAEA--REKE 1482
Query: 655 TRPKFLSRDVDSEI---SDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYK 711
T+ L+R ++ + +LE + A++ +L + K++ E+ + + +
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542
Query: 712 ELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKS 771
E+K ++ + E++ E+ + V++ L+ + + + E +Q + H
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1602
Query: 772 LKIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNK 831
++E E K A+ + +L LKD ADS + + ++E + L K
Sbjct: 1603 TELEDERKQRALAAAAKK--KLEGDLKDLELQADSAI-----------KGREEAIKQLRK 1649
Query: 832 KKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHG----D 887
+ ++ ++ELE+ + +I E EK A L+ ++ +L++ + A + +
Sbjct: 1650 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1709
Query: 888 REEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIME 924
+EE+ + + L + R L+ I L E +E
Sbjct: 1710 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1746
Score = 63.2 bits (152), Expect = 1e-09
Identities = 132/707 (18%), Positives = 292/707 (41%), Gaps = 96/707 (13%)
Query: 256 ERFQSIAGLSTMKTNLES---LKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKME 312
+R Q + + ++ N + L++ W + +++ L R E+ A+ D +++
Sbjct: 808 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQE----EEMQAKED-ELQ 862
Query: 313 EQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLN 372
+ + R +AE + K+++ K +++EE N L+ + A+ Y EAE + R
Sbjct: 863 KTKERQQKAENELKELEQKHSQLTEEKNL-------LQEQLQAETELYAEAEEMRVRLAA 915
Query: 373 EYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIE 432
+ + L++ ++ R+EE ++ Q L+ ER + +++ L+E+++ +E + Q+++
Sbjct: 916 KKQELEEILHEMEARLEE-EEDRGQQLQAERKKMAQQMLDLEEQLE----EEEAARQKLQ 970
Query: 433 QFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAID 492
+EK E KIK+ E ++ N + KE K +R+ N+ E
Sbjct: 971 -----LEKVTAE-AKIKKLEDEILVMDDQNNKLSKERK-LLEERISDLTTNLAEEEEKAK 1023
Query: 493 DAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRF 552
+ + + + L + L+ E + LK L+ H LQA
Sbjct: 1024 NLTKLKNKHESMISELE--VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ---- 1077
Query: 553 YLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVL 612
++E + ++ A + L L+ + A N+L +R +E +
Sbjct: 1078 -----------IAELKMQL------AKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1120
Query: 613 LIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENT-----RPKFLSRDVDSE 667
S + + S++ +N E D + E+T + L + E
Sbjct: 1121 -----SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE 1175
Query: 668 ISDLENEVENKT----AQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISE 723
++ L+ ++ +T AQ+ ++Q + +++ E KR + + + K + K ++
Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1235
Query: 724 I-----------RELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSL 772
+ +E+E+ ++ + L+ + + + + + + + + +E + +
Sbjct: 1236 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1295
Query: 773 KIEAENKYDAIKFKINQLSELADPLKDELNLADSEVD---NQKRGKRHYEEKQKEHLDTL 829
EAE K AIK ++ L+ L+D L E N R EE++ D L
Sbjct: 1296 LNEAEGK--AIKL-AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL 1352
Query: 830 NKK-------KRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEH 882
+++ +R + +L + + + +E+ KEI L Q+ + +
Sbjct: 1353 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1412
Query: 883 ASHGDREEIM-RQYQEARETYLDLDSKVRTL-------KKFIKLLGE 921
A++ E+ R QE + +DLD++ + + +KF +LL E
Sbjct: 1413 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1459
Score = 45.4 bits (106), Expect = 3e-04
Identities = 58/286 (20%), Positives = 125/286 (43%), Gaps = 21/286 (7%)
Query: 662 RDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNE----ELLKRCQLHYKELKMKI 717
R + ++ + E E+E++ Q LE D+K E +K + K+L+ K+
Sbjct: 1592 RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR-KL 1650
Query: 718 RKNISEI-RELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEA 776
+ + + RELE+ + AT A+EN+ K K +E + Q +E++ + + +A
Sbjct: 1651 QAQMKDFQRELEDARASRDEIFAT----AKENEKKAKSLEADLMQLQEDLAAAERARKQA 1706
Query: 777 ENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKREL 836
+ + + + ++ + L+DE ++ + + + + D + K ++
Sbjct: 1707 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1766
Query: 837 DMKEKELEEKMSQARQICPERIEVEKSASILDKEI--------NRLRQKIQAEHASHGDR 888
+ EL + S A++ R ++E+ L ++ ++ + I A A
Sbjct: 1767 EQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1826
Query: 889 EEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFR 934
EE + QEARE S + KK ++L ++ + R K +Q++
Sbjct: 1827 EEQVE--QEAREKQAATKSLKQKDKKLKEILLQVEDER-KMAEQYK 1869
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 87.0 bits (214), Expect = 9e-17
Identities = 132/684 (19%), Positives = 289/684 (42%), Gaps = 122/684 (17%)
Query: 212 KATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEK-EERFQSIAGLSTMKTN 270
KA M + S + + + + + Q E L E K++ ++ ++ + + +++ +
Sbjct: 1358 KAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCAS 1417
Query: 271 LESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAA--RLDRKMEEQQVRLNEAEQKYKDI 328
LE K + NE+E + I + AA LD+K L E +QKY++
Sbjct: 1418 LEKTKQRLQ----NEVEDLM------IDVERSNAACIALDKKQRNFDKVLAEWKQKYEET 1467
Query: 329 QDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRI 388
Q +LE A E +L ++ K AY E SL+ + LK++++ L + I
Sbjct: 1468 QAELE-------ASQKESRSLSTELFKVKNAYEE-------SLDHLETLKRENKNLQQEI 1513
Query: 389 EELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEHGKI 448
+L + + E K I L++ K ++++ + +E+ + ++E E GKI
Sbjct: 1514 SDLTE--------QIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLE---HEEGKI 1562
Query: 449 KREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPL 508
R +L++ S R++ E KD + D+LKR V +++ DA
Sbjct: 1563 LRIQLELNQVKSEIDRKIAE-KDEELDQLKRNHLRVVESMQSTLDA-------------- 1607
Query: 509 GACIHLRDPELALAIESCLKG-LLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEF 567
+R AL I+ ++G L + NHA+ + +AL
Sbjct: 1608 ----EIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALR------------------ 1645
Query: 568 RNEIYDVRHRAAYHPDFPTVLTALEIDNAV-----VANSLIDMRGIETVLLIKNNSVARA 622
++R+ D T L +D+A+ + L + ++ + + +
Sbjct: 1646 -----NLRNTQGILKD-----TQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRAS 1695
Query: 623 VMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQI 682
+ ++++ K + ++V + ++NT + ++++IS ++ E+E+ +
Sbjct: 1696 LERTERGRKMAEQELLDASERV---QLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEA 1752
Query: 683 LNLQQHLSALEKDIKHNEELLKRCQ---LHYKELKMKIRKNISEIRELENIEEHQSVDIA 739
N ++ D E LK+ Q H + +K + + + +++ ++E + + +
Sbjct: 1753 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQ--LRLDEAEQLALK 1810
Query: 740 TLEDEAQENKSKMKMVEEHME-QQKENMEHLKSLKIEAENKYDAIKFKINQLSELADPLK 798
+ + Q+ +++++ +E +E +QK N+E +K L+ + E + + ++ + + L+
Sbjct: 1811 GGKKQIQKLEARVRELESEVESEQKHNVEAVKGLR-KHERRVKELTYQTEEDRKNILRLQ 1869
Query: 799 DELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERI 858
D ++ ++V KR EE+ +L K + EL+
Sbjct: 1870 DLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELE--------------------- 1908
Query: 859 EVEKSASILDKEINRLRQKIQAEH 882
E ++ A I + ++N+LR K + H
Sbjct: 1909 EAKERADIAESQVNKLRVKSREVH 1932
Score = 58.2 bits (139), Expect = 4e-08
Identities = 165/844 (19%), Positives = 329/844 (38%), Gaps = 154/844 (18%)
Query: 155 KLKSATGSVVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKA- 213
K K AT + V EE+ A LD ++ L + + + E DK KA
Sbjct: 970 KEKHATENKVKNLTEEM-AGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAK 1028
Query: 214 TQLEQMKEDYSYIMETK-------ERTKEQIHQGEERLTELKRQCVE--KEERFQSIAGL 264
T+LEQ +D +E + ER K ++ +G+ +L + E K++ + +
Sbjct: 1029 TKLEQQVDDLEGSLEQEKKLCMDLERAKRKL-EGDLKLAQESTMDTENDKQQLNEKLKKK 1087
Query: 265 STMKTNLES-LKHEMAWAV------------VNEIEKQLNAIRDNIKIGEDRAARLDRKM 311
+NL+ ++ E A A+ + E+E+++ A R + E + + L R++
Sbjct: 1088 EFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL 1147
Query: 312 EEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSL 371
EE RL EA T+A+ +A+ +R E+ + + +
Sbjct: 1148 EEISERLEEA--------------GGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATA 1193
Query: 372 NEYKALKKDD-EQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQE 430
+ D +L ++I+ L++ Q LE E+ E + +I+ L ++ + + +
Sbjct: 1194 AALRKKHADSVAELGEQIDSLQR-VKQKLEKEKSELKMEINDLASNMETVSKAKANFEKM 1252
Query: 431 IEQFQQAIE--KDKEEHGKIKREELDVKHALSYNQ-----RQLKELKDSKTDRLKRFGPN 483
+ + K KEE + EL + A + + RQL E KD+ +L R
Sbjct: 1253 CRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDE-KDAMVSQLSR---G 1308
Query: 484 VPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADER 543
A + I++ RQ K L + + L E + +E+
Sbjct: 1309 KQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLRE-------------QYEEEQ 1355
Query: 544 VLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLI 603
+A ++R G S+ V+++R + Y D LE +A L
Sbjct: 1356 EAKAELQR----GMSKANSEVAQWRTK---------YETDAIQRTEELEEAKKKLAQRLQ 1402
Query: 604 DM-RGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAG--------RYYSSEN 654
D +E V NS ++ ++++ +N E D ++ A R +
Sbjct: 1403 DAEEHVEAV-----NSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVL 1457
Query: 655 TRPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELL---KRCQLHYK 711
K + +E+ + E + + ++ ++ +A E+ + H E L K Q
Sbjct: 1458 AEWKQKYEETQAELEASQKESRSLSTELFKVK---NAYEESLDHLETLKRENKNLQQEIS 1514
Query: 712 ELKMKIRKNISEIRELENIE---EHQSVDIATLEDEAQ---------------------- 746
+L +I + I ELE ++ +H+ ++ T +EA+
Sbjct: 1515 DLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKS 1574
Query: 747 ENKSKMKMVEEHMEQQKEN----MEHLKS-LKIEAENKYDAIKFKINQLSELADPLKDEL 801
E K+ +E ++Q K N +E ++S L E ++ DA++ K +L + ++ +L
Sbjct: 1575 EIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDL-NEMEIQL 1633
Query: 802 NLADSEVDNQKRGKRHYEEKQKE---HLDTL----NKKKRELDMKEKELEEKMSQARQIC 854
N A+ + R R+ + K+ HLD + K +L M E+ ++ ++
Sbjct: 1634 NHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELR 1693
Query: 855 PERIEVEKSASILDKEINRLRQKIQAEHASH------------------GDREEIMRQYQ 896
E+ + ++E+ +++Q H + G+ E+I+++ +
Sbjct: 1694 ASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEAR 1753
Query: 897 EARE 900
A E
Sbjct: 1754 NAEE 1757
Score = 53.1 bits (126), Expect = 1e-06
Identities = 153/877 (17%), Positives = 323/877 (36%), Gaps = 158/877 (18%)
Query: 192 EMSKQFLQSKNEGDKYKFFMKATQLE--QMKEDYSYIMETKERTKEQIHQGEERLTELKR 249
E K+ K E +K K + T+ + +++E +M+ K + Q+ + L + +
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEE 907
Query: 250 QCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDR 309
+C + L K LE+ E+ +E E K+ ED + L +
Sbjct: 908 RCDQ----------LIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKL-EDECSELKK 956
Query: 310 KMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNR 369
+++ ++ L + E++ ++K++ ++EE MA + +AK
Sbjct: 957 DIDDLELTLAKVEKEKHATENKVKNLTEE--------MAGLDETIAK------------- 995
Query: 370 SLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQ 429
L K + L+++ Q+L+ ++E K + K + K + Q
Sbjct: 996 --------------LTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTK--------LEQ 1033
Query: 430 EIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSK---TDRLKRFGPNVPA 486
+++ + ++E++K+ ++R + ++ L Q + ++ K ++LK+ +
Sbjct: 1034 QVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSN 1093
Query: 487 LLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHAD-ERVL 545
L I+D K + L A I + E+ S K Q +D R L
Sbjct: 1094 LQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQ------RSDLSREL 1147
Query: 546 QALMKRFYLPGTSRPPII------VSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVA 599
+ + +R G + I +EF+ D+ H L D+
Sbjct: 1148 EEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAEL 1207
Query: 600 NSLID--------MRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYS 651
ID + ++ L ++ N +A + K N + DQ+ +
Sbjct: 1208 GEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKE 1267
Query: 652 SENTRPKFLSRDVDSEISDLENE-------VENKTAQILNLQQHLSALEKDIKHNEELLK 704
E R L ++ ++ + L E ++ K A + L + A + I+ + L+
Sbjct: 1268 EEQQR---LINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLE 1324
Query: 705 ---RCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEE---- 757
+ + R + +RE E+ ++ +A ++ + E
Sbjct: 1325 EETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAI 1384
Query: 758 -HMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSELADPLKDEL----------NLADS 806
E+ +E + L +AE +A+ K L + L++E+ N A
Sbjct: 1385 QRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACI 1444
Query: 807 EVDNQKRG--------KRHYEEKQKE---------------------------HLDTLNK 831
+D ++R K+ YEE Q E HL+TL +
Sbjct: 1445 ALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKR 1504
Query: 832 KKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDRE-E 890
+ + L + +L E++++ + E +V+K LD E + L+ ++ AS E +
Sbjct: 1505 ENKNLQQEISDLTEQIAEGGKHIHELEKVKKQ---LDHEKSELQTSLEEAEASLEHEEGK 1561
Query: 891 IMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNLLS 950
I+R E + ++D K+ + L ++ + + + + L + D L
Sbjct: 1562 ILRIQLELNQVKSEIDRKIAEKD---EELDQLKRNHLRVVESMQSTLDAEIRSRNDALRI 1618
Query: 951 QRAYCGKMNFDHKNETLSISVQPGEGNKAAFNDMRAL 987
++ G +N + +Q N+ A +R L
Sbjct: 1619 KKKMEGDLN--------EMEIQLNHANRQAAEALRNL 1647
Score = 51.6 bits (122), Expect = 4e-06
Identities = 51/277 (18%), Positives = 116/277 (41%), Gaps = 25/277 (9%)
Query: 663 DVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNIS 722
D +LE + ++ + ++H+ A+ E+ +R Q ++L + + ++ +
Sbjct: 1382 DAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNA 1441
Query: 723 EIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQ-----------QKENMEHLKS 771
L+ + + +A + + +E +++++ ++ +E+++HL++
Sbjct: 1442 ACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLET 1501
Query: 772 LKIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLD---- 827
LK E +N I Q++E + EL ++D++K + E+ + L+
Sbjct: 1502 LKRENKNLQQEISDLTEQIAEGGKHI-HELEKVKKQLDHEKSELQTSLEEAEASLEHEEG 1560
Query: 828 -------TLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQA 880
LN+ K E+D K E +E++ Q ++ VE S LD EI ++
Sbjct: 1561 KILRIQLELNQVKSEIDRKIAEKDEELDQLKR--NHLRVVESMQSTLDAEIRSRNDALRI 1618
Query: 881 EHASHGDREEIMRQYQEARETYLDLDSKVRTLKKFIK 917
+ GD E+ Q A + +R + +K
Sbjct: 1619 KKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILK 1655
Score = 46.6 bits (109), Expect = 1e-04
Identities = 62/329 (18%), Positives = 139/329 (42%), Gaps = 37/329 (11%)
Query: 162 SVVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKE 221
S + T EE A L+H ++ + + Q K+E D+ K K +L+Q+K
Sbjct: 1542 SELQTSLEEAEASLEHEEGKI--------LRIQLELNQVKSEIDR-KIAEKDEELDQLKR 1592
Query: 222 DYSYIMET------------------KERTKEQIHQGEERLTELKRQCVEKEERFQSIAG 263
++ ++E+ K++ + +++ E +L RQ E ++ G
Sbjct: 1593 NHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQG 1652
Query: 264 LSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQ 323
+ +K L + A +++++QL + + + L +E + AEQ
Sbjct: 1653 I--LKDT--QLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQ 1708
Query: 324 KYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQ 383
+ D ++++ + + + L+ D+ + E E + + N + KK
Sbjct: 1709 ELLDASERVQLLHTQNTSLINTKKKLETDI---SQIQGEMEDIVQEARNAEEKAKKAITD 1765
Query: 384 LCKRIEELKKSTDQSLEPERLER--QKKISWLKERV-KAFQNQENSVNQEIEQFQQAIEK 440
EELKK D S ER+++ ++ + L+ R+ +A Q ++I++ + + +
Sbjct: 1766 AAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRE 1825
Query: 441 DKEEHGKIKREELDVKHALSYNQRQLKEL 469
+ E ++ ++ L ++R++KEL
Sbjct: 1826 LESEVESEQKHNVEAVKGLRKHERRVKEL 1854
Score = 33.5 bits (75), Expect = 1.1
Identities = 46/234 (19%), Positives = 101/234 (43%), Gaps = 20/234 (8%)
Query: 697 KHNEELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQE--NKSKMKM 754
K +E+LL ++ + + K K + L +EE + +A L Q M++
Sbjct: 744 KASEKLLGSIEIDHTQYKFGHTKVFFKAGLLGTLEEMRDEKLAQLITRTQAICRGFLMRV 803
Query: 755 VEEHMEQQKENM----EHLKSLKIEAENKYDAIKFKINQLSELADP------LKDELNLA 804
M +++E++ ++++ + + FKI L + A+ +K+E
Sbjct: 804 EFRKMMERRESIFCIQYNIRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMANMKEEFEKT 863
Query: 805 DSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSA 864
E+ + ++ EEK + TL ++K +L ++ + + ++ A + C + I K+
Sbjct: 864 KEELAKTEAKRKELEEK----MVTLMQEKNDLQLQVQAEADALADAEERCDQLI---KTK 916
Query: 865 SILDKEINRLRQKIQAEHASHGDREEIMRQYQ-EARETYLDLDSKVRTLKKFIK 917
L+ +I + ++ + E + + R+ + E E D+D TL K K
Sbjct: 917 IQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK 970
>gi|4885399 structural maintenance of chromosomes 3 [Homo sapiens]
Length = 1217
Score = 86.7 bits (213), Expect = 1e-16
Identities = 218/1192 (18%), Positives = 449/1192 (37%), Gaps = 260/1192 (21%)
Query: 67 FGSNVNFVVGNNGSGKSAVLTALIVGLGGRAVATNRGSSLKGFVKDGQNSADISITLRNR 126
F S N +VG NGSGKS A+ L + R + +G IS
Sbjct: 23 FSSKHNVIVGRNGSGKSNFFYAIQFVLSDE-FSHLRPEQRLALLHEGTGPRVIS------ 75
Query: 127 GDDAFKASVYGNSILIQQHISIDGSRSYKLKSATGSVVS--------TRKEELIAILDHF 178
AF ++ NS + ID L+ G+ K +++ +L+
Sbjct: 76 ---AFVEIIFDNS---DNRLPID-KEEVSLRRVIGAKKDQYFLDKKMVTKNDVMNLLESA 128
Query: 179 NIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQL----EQMKEDYSYIMET---KE 231
NP ++ Q Q + + + + K + E+ +E S + ET +E
Sbjct: 129 GFSRSNPYYIVKQGKINQ-MATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKRE 187
Query: 232 RTKEQIHQGEERLTELKRQCVE-------------------KEERFQSIAGLSTMKTNLE 272
+ E + EERL L+ + E +E ++ A L + E
Sbjct: 188 KINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRE 247
Query: 273 SLKHEM---------AWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQ 323
+ + A + +IE+Q+ ++ I ++ +L + +EQ + + E
Sbjct: 248 TSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLEL 307
Query: 324 KYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQ 383
K KD+QD+L SE+ E L + K++ E E +N +K++
Sbjct: 308 KAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFN------SVKEKEERG 361
Query: 384 LCKRIEELKKSTD----QSLEPERLERQKKISWLKERVKAFQN----------------- 422
+ + + ++ TD Q + ++++ W+K+ +K+
Sbjct: 362 IARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLE 421
Query: 423 -----------QENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQ------ 465
Q N ++Q++ + + +E+ ++ ++K ++ +++ +Y R+
Sbjct: 422 DTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQ 481
Query: 466 ---LKELKDSKTDRLKRFGPNVPALLEAIDDAYRQ-GHFTYKPV------GPLGACIHLR 515
K K +L R A+L ID + HF K + G G I +
Sbjct: 482 ALAAKREDLEKKQQLLRAATG-KAILNGIDSINKVLDHFRRKGINQHVQNGYHG--IVMN 538
Query: 516 DPELALAIESCLKGLLQAYCCHN--HADERVLQALMK--RFYLPGTSRPPIIVSEFRNEI 571
+ E A +C++ ++ +DE + LM+ + LPG V+
Sbjct: 539 NFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGE------VTFLPLNK 592
Query: 572 YDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPK 631
DVR A +P A+ + + + N D K+ + +S +
Sbjct: 593 LDVRDTA-----YPETNDAIPMISKLRYNPRFDKA-------FKHVFGKTLICRSMEVST 640
Query: 632 NCREAFTAD-----GDQV-----FAGRYYSSENTRPKFLSRDV---DSEISDLE------ 672
AFT D GDQV G YY + +R + L +DV + E+ +LE
Sbjct: 641 QLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLE-LQKDVRKAEEELGELEAKLNEN 699
Query: 673 -----NEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNI------ 721
+ N+ Q++N Q + ++ K + + + KE + + K
Sbjct: 700 LRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRS 759
Query: 722 -----SEIRELENIEEHQSVDIAT--LEDEAQENKSKMKMVEEHMEQ-QKENMEHLKS-L 772
+ + +E+ E ++ T L + E++ ++ + + + Q Q+EN + L +
Sbjct: 760 LQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERI 819
Query: 773 KIEA-------------ENKYDAIKFKINQLSEL-------------------------- 793
K+E + D ++ ++N+L E
Sbjct: 820 KLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGTVLTATTSELEAINKRVKDTMAR 879
Query: 794 ADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELD-------MKEKELEEK 846
++ L + ++ ++ + ++ ++ +KEH+D +N +EL+ M K+ EE
Sbjct: 880 SEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEEC 939
Query: 847 MSQARQI--CPERIEVEKSASILDKEINRLRQKIQAE--HASHGDREEIMR--QYQEARE 900
M + R++ P+ EK ++ K++ R ++ E SH +++ + + + E +E
Sbjct: 940 MKKIRELGSLPQE-AFEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKE 998
Query: 901 TYLDLDSKV-RTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNLL---------- 949
+ ++ R K ++L+ + +++ Q + ++ F L+
Sbjct: 999 KLIKRQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVMK 1058
Query: 950 ------SQRAYCGKMNFDHKNETLSISVQPG-------------EGNKAAFNDMRALSGG 990
SQ G+ + + + + S S P G + +M+ LSGG
Sbjct: 1059 KGDVEGSQSQDEGEGSGESERGSGSQSSVPSVDQFTGVGIRVSFTGKQGEMREMQQLSGG 1118
Query: 991 ERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRRIAMDLILKMADSQRF 1042
++S + I ++ +PF DE D +D +R+ D+I+++A +F
Sbjct: 1119 QKSLVALALIFAIQKCDPAPFYLFDEIDQALDAQHRKAVSDMIMELAVHAQF 1170
>gi|50658065 SMC4 structural maintenance of chromosomes 4-like 1 [Homo
sapiens]
Length = 1288
Score = 86.3 bits (212), Expect = 1e-16
Identities = 191/1008 (18%), Positives = 405/1008 (40%), Gaps = 198/1008 (19%)
Query: 52 HLKNFMCHSMLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGRAVATNRGSSLKGFVK 111
+ K++ +LGPF + ++G NGSGKS V+ +++ G RA R L +
Sbjct: 91 NFKSYAGEKILGPFH--KRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKI-RSKKLSVLIH 147
Query: 112 DGQNSADI-SITLR--------NRGDD----------------AFKASVY---------- 136
+ DI S T+ GDD SVY
Sbjct: 148 NSDEHKDIQSCTVEVHFQKIIDKEGDDYEVIPNSNFYVSRTACRDNTSVYHISGKKKTFK 207
Query: 137 --GNSILIQQH-ISIDGSRSYKLKSATGSVVSTRK----EELIAILDHFNI-----QVDN 184
GN L++ H I +D +R L+ + + E +L++ +++
Sbjct: 208 DVGN--LLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNE 265
Query: 185 PVSVLTQEMSKQFLQSKNEGDKY-KFFMKATQLEQMKEDYSYIME----TKERTKEQIHQ 239
P+ VL + + + +++ G+K + M + + ++ + + +E E +++ H
Sbjct: 266 PIKVLCRRVE---ILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHV 322
Query: 240 GEERLTELKRQCVEKE---ERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDN 296
+ + EL+++ E E E+ K+N+ S + + V + EK+LN I
Sbjct: 323 CQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKF 382
Query: 297 IKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAK 356
I+ +++ +LD + + + +L A K K ++ +L+K E+ E ++ A
Sbjct: 383 IEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVE----EFKSIPA----- 433
Query: 357 KRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELK---KSTDQSLEPERLERQKKISWL 413
++ + N + AL+K+ E+ K+++E+ K Q L+ E+ R+K++
Sbjct: 434 -----KSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGF 488
Query: 414 KERVK--------------AFQNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHAL 459
+ V + ++ N+ ++ + ++A+ E + K D++ L
Sbjct: 489 SKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKL 548
Query: 460 SYNQRQLKELKDSKTDRLKRFGPNVPAL------------------------LEAIDDAY 495
+++LKE K+ + +L + N +L L+AI
Sbjct: 549 PQTEQELKE-KEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEK 607
Query: 496 RQGHF--TYKPVGPLGACIHLRDPELALAIESCLKGLLQ--------AYCCHNHADERVL 545
+ G Y +G LGA D + +AI SC L A C N + +
Sbjct: 608 KSGRIPGIYGRLGDLGAI----DEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNI 663
Query: 546 QAL----MKRFYLPGTSRPPIIVSEFRNEIYDV------RHRAAYHPDFPTVLTALEIDN 595
+ + + I E ++D+ + R A++ L A +D
Sbjct: 664 GVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQ 723
Query: 596 AVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENT 655
A D R V+ ++ + ++ T G +V GR SS
Sbjct: 724 ATRVAYQKDRRW--RVVTLQGQIIEQS------------GTMTGGGSKVMKGRMGSS--- 766
Query: 656 RPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEK---DIKHNEELLKRCQLHYKE 712
+ + E++ +E++++N + + + +Q+ LE+ ++H+E +E
Sbjct: 767 ---LVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSE----------RE 813
Query: 713 LKMKIRKNISEIRELENIEEHQSVDIATLEDE---AQENKSKMKMVEEHMEQQKENMEHL 769
++ + K + I+ L EE+ +V + LE +K K K++EE++ K + +
Sbjct: 814 MRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAV 873
Query: 770 --KSLKIEAENK------YDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEK 821
K+ K+EAE K + K+ + D + +L+ S + + + +
Sbjct: 874 AEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRN 933
Query: 822 QKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAE 881
++ D++ + ++E+ EKE+++ ++ + + + EV K+ + ++ + +IQ E
Sbjct: 934 LQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESL----PEIQKE 989
Query: 882 HASHGDREEIMRQYQEARETYLDLDSKVRTLK-KFIKLLGEIMEHRFK 928
H ++++ + +E L ++K K ++ G I EH K
Sbjct: 990 H------RNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSK 1031
Score = 62.8 bits (151), Expect = 2e-09
Identities = 90/420 (21%), Positives = 173/420 (41%), Gaps = 49/420 (11%)
Query: 664 VDSEISDLENEVENKTAQILNLQQH-LSALEKDIKHNEELLKRCQLHYKELKMKIRK--- 719
V++E+ L N + L QQ L + K + + + Q+ K ++K
Sbjct: 880 VEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQD 939
Query: 720 ----NISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHM-EQQKENMEHLKSLKI 774
EI++ E + + ++ +LED+A E EE + E QKE+ L+ LK+
Sbjct: 940 SVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKV 999
Query: 775 EAENKYDAIKFKINQLSELADPLKDELNLADSEV-DNQKRGKRHYEEKQKEHLDTLNKKK 833
EN++ L + A +K +L D + ++ + K ++E K L +
Sbjct: 1000 IQENEH--------ALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIE--- 1048
Query: 834 RELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMR 893
+ + + + PE +E K+ + +I L + + G +
Sbjct: 1049 ----------DNPIEEISVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLG----AIA 1094
Query: 894 QYQEARETYL----DLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNL- 948
+Y++ E YL +LD F + ++ + R + +T + K + L
Sbjct: 1095 EYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLT 1154
Query: 949 LSQRAYCGKMN-FDHKNETLSISVQPGEGN-KAAFNDMRALSGGERSFSTVCFILSLWSI 1006
L A ++ D +E + SV+P + + K FN LSGGE++ S++ + +L
Sbjct: 1155 LGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFN----LSGGEKTLSSLALVFALHHY 1210
Query: 1007 AESPFRCLDEFDVYMDMVNRRIAMDLILKMADSQRFRQFILLTPQSMSSLPSSKLIRILR 1066
+P +DE D +D N I I + + QFI+++ ++ S +LI I +
Sbjct: 1211 KPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKN---AQFIIISLRNNMFEISDRLIGIYK 1267
Score = 36.2 bits (82), Expect = 0.17
Identities = 27/134 (20%), Positives = 61/134 (45%), Gaps = 2/134 (1%)
Query: 283 VNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNAR 342
+++I KQL+ I + DR +++ Q + E++ KD + +++ ++ E +
Sbjct: 906 LDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSL 965
Query: 343 APECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPE 402
+ + + A + + E + + L E K +++++ L K +K +Q ++
Sbjct: 966 EDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQ-IDGH 1024
Query: 403 RLERQKKIS-WLKE 415
E KI W KE
Sbjct: 1025 IAEHNSKIKYWHKE 1038
>gi|50658063 SMC4 structural maintenance of chromosomes 4-like 1 [Homo
sapiens]
Length = 1288
Score = 86.3 bits (212), Expect = 1e-16
Identities = 191/1008 (18%), Positives = 405/1008 (40%), Gaps = 198/1008 (19%)
Query: 52 HLKNFMCHSMLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGRAVATNRGSSLKGFVK 111
+ K++ +LGPF + ++G NGSGKS V+ +++ G RA R L +
Sbjct: 91 NFKSYAGEKILGPFH--KRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKI-RSKKLSVLIH 147
Query: 112 DGQNSADI-SITLR--------NRGDD----------------AFKASVY---------- 136
+ DI S T+ GDD SVY
Sbjct: 148 NSDEHKDIQSCTVEVHFQKIIDKEGDDYEVIPNSNFYVSRTACRDNTSVYHISGKKKTFK 207
Query: 137 --GNSILIQQH-ISIDGSRSYKLKSATGSVVSTRK----EELIAILDHFNI-----QVDN 184
GN L++ H I +D +R L+ + + E +L++ +++
Sbjct: 208 DVGN--LLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNE 265
Query: 185 PVSVLTQEMSKQFLQSKNEGDKY-KFFMKATQLEQMKEDYSYIME----TKERTKEQIHQ 239
P+ VL + + + +++ G+K + M + + ++ + + +E E +++ H
Sbjct: 266 PIKVLCRRVE---ILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHV 322
Query: 240 GEERLTELKRQCVEKE---ERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDN 296
+ + EL+++ E E E+ K+N+ S + + V + EK+LN I
Sbjct: 323 CQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKF 382
Query: 297 IKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAK 356
I+ +++ +LD + + + +L A K K ++ +L+K E+ E ++ A
Sbjct: 383 IEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVE----EFKSIPA----- 433
Query: 357 KRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELK---KSTDQSLEPERLERQKKISWL 413
++ + N + AL+K+ E+ K+++E+ K Q L+ E+ R+K++
Sbjct: 434 -----KSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGF 488
Query: 414 KERVK--------------AFQNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHAL 459
+ V + ++ N+ ++ + ++A+ E + K D++ L
Sbjct: 489 SKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKL 548
Query: 460 SYNQRQLKELKDSKTDRLKRFGPNVPAL------------------------LEAIDDAY 495
+++LKE K+ + +L + N +L L+AI
Sbjct: 549 PQTEQELKE-KEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEK 607
Query: 496 RQGHF--TYKPVGPLGACIHLRDPELALAIESCLKGLLQ--------AYCCHNHADERVL 545
+ G Y +G LGA D + +AI SC L A C N + +
Sbjct: 608 KSGRIPGIYGRLGDLGAI----DEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNI 663
Query: 546 QAL----MKRFYLPGTSRPPIIVSEFRNEIYDV------RHRAAYHPDFPTVLTALEIDN 595
+ + + I E ++D+ + R A++ L A +D
Sbjct: 664 GVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQ 723
Query: 596 AVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENT 655
A D R V+ ++ + ++ T G +V GR SS
Sbjct: 724 ATRVAYQKDRRW--RVVTLQGQIIEQS------------GTMTGGGSKVMKGRMGSS--- 766
Query: 656 RPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEK---DIKHNEELLKRCQLHYKE 712
+ + E++ +E++++N + + + +Q+ LE+ ++H+E +E
Sbjct: 767 ---LVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSE----------RE 813
Query: 713 LKMKIRKNISEIRELENIEEHQSVDIATLEDE---AQENKSKMKMVEEHMEQQKENMEHL 769
++ + K + I+ L EE+ +V + LE +K K K++EE++ K + +
Sbjct: 814 MRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAV 873
Query: 770 --KSLKIEAENK------YDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEK 821
K+ K+EAE K + K+ + D + +L+ S + + + +
Sbjct: 874 AEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRN 933
Query: 822 QKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAE 881
++ D++ + ++E+ EKE+++ ++ + + + EV K+ + ++ + +IQ E
Sbjct: 934 LQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESL----PEIQKE 989
Query: 882 HASHGDREEIMRQYQEARETYLDLDSKVRTLK-KFIKLLGEIMEHRFK 928
H ++++ + +E L ++K K ++ G I EH K
Sbjct: 990 H------RNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSK 1031
Score = 62.8 bits (151), Expect = 2e-09
Identities = 90/420 (21%), Positives = 173/420 (41%), Gaps = 49/420 (11%)
Query: 664 VDSEISDLENEVENKTAQILNLQQH-LSALEKDIKHNEELLKRCQLHYKELKMKIRK--- 719
V++E+ L N + L QQ L + K + + + Q+ K ++K
Sbjct: 880 VEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQD 939
Query: 720 ----NISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHM-EQQKENMEHLKSLKI 774
EI++ E + + ++ +LED+A E EE + E QKE+ L+ LK+
Sbjct: 940 SVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKV 999
Query: 775 EAENKYDAIKFKINQLSELADPLKDELNLADSEV-DNQKRGKRHYEEKQKEHLDTLNKKK 833
EN++ L + A +K +L D + ++ + K ++E K L +
Sbjct: 1000 IQENEH--------ALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIE--- 1048
Query: 834 RELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMR 893
+ + + + PE +E K+ + +I L + + G +
Sbjct: 1049 ----------DNPIEEISVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLG----AIA 1094
Query: 894 QYQEARETYL----DLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNL- 948
+Y++ E YL +LD F + ++ + R + +T + K + L
Sbjct: 1095 EYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLT 1154
Query: 949 LSQRAYCGKMN-FDHKNETLSISVQPGEGN-KAAFNDMRALSGGERSFSTVCFILSLWSI 1006
L A ++ D +E + SV+P + + K FN LSGGE++ S++ + +L
Sbjct: 1155 LGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFN----LSGGEKTLSSLALVFALHHY 1210
Query: 1007 AESPFRCLDEFDVYMDMVNRRIAMDLILKMADSQRFRQFILLTPQSMSSLPSSKLIRILR 1066
+P +DE D +D N I I + + QFI+++ ++ S +LI I +
Sbjct: 1211 KPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKN---AQFIIISLRNNMFEISDRLIGIYK 1267
Score = 36.2 bits (82), Expect = 0.17
Identities = 27/134 (20%), Positives = 61/134 (45%), Gaps = 2/134 (1%)
Query: 283 VNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNAR 342
+++I KQL+ I + DR +++ Q + E++ KD + +++ ++ E +
Sbjct: 906 LDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSL 965
Query: 343 APECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPE 402
+ + + A + + E + + L E K +++++ L K +K +Q ++
Sbjct: 966 EDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQ-IDGH 1024
Query: 403 RLERQKKIS-WLKE 415
E KI W KE
Sbjct: 1025 IAEHNSKIKYWHKE 1038
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 85.9 bits (211), Expect = 2e-16
Identities = 127/682 (18%), Positives = 288/682 (42%), Gaps = 118/682 (17%)
Query: 212 KATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEK-EERFQSIAGLSTMKTN 270
KA M + S + + + + + Q E L E K++ ++ ++ + + ++ +
Sbjct: 1358 KAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCAS 1417
Query: 271 LESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQD 330
LE K + NE+E + +++ A LD+K L E +QK ++
Sbjct: 1418 LEKTKQRLQ----NEVED----LMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHA 1469
Query: 331 KLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEE 390
+LE +E+ + + E + K AY E SL++ + LK++++ L + I +
Sbjct: 1470 ELEASQKESRSLSTELFKI-------KNAYEE-------SLDQLETLKRENKNLQQEISD 1515
Query: 391 LKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEHGKIKR 450
L + + E K+I L++ K + +++ + +E+ + ++E E GKI R
Sbjct: 1516 LTE--------QIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLE---HEEGKILR 1564
Query: 451 EELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGA 510
+L++ S R++ E KD + D++KR + +++ DA
Sbjct: 1565 IQLELNQVKSEVDRKIAE-KDEEIDQMKRNHIRIVESMQSTLDA---------------- 1607
Query: 511 CIHLRDPELALAIESCLKG-LLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRN 569
+R A+ ++ ++G L + NHA+ +AL
Sbjct: 1608 --EIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALR-------------------- 1645
Query: 570 EIYDVRHRAAYHPDFPTVLTALEIDNAV-----VANSLIDMRGIETVLLIKNNSVARAVM 624
+ R+ A D T L +D+A+ + L + +L + + +
Sbjct: 1646 ---NYRNTQAILKD-----TQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLE 1697
Query: 625 QSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQILN 684
Q+++ K + ++V + ++NT + ++++IS ++ E+E+ + N
Sbjct: 1698 QTERSRKIAEQELLDASERV---QLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARN 1754
Query: 685 LQQHLSALEKDIKHNEELLKRCQ---LHYKELKMKIRKNISEIRELENIEEHQSVDIATL 741
++ D E LK+ Q H + +K + + + +++ ++E + + +
Sbjct: 1755 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQ--HRLDEAEQLALKGG 1812
Query: 742 EDEAQENKSKMKMVEEHME-QQKENMEHLKSLKIEAENKYDAIKFKINQLSELADPLKDE 800
+ + Q+ +++++ +E +E +QK N+E +K L+ + E K + ++ + + L+D
Sbjct: 1813 KKQIQKLEARVRELEGEVESEQKRNVEAVKGLR-KHERKVKELTYQTEEDRKNILRLQDL 1871
Query: 801 LNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEV 860
++ ++V + KR EE+ +L + + EL+ E
Sbjct: 1872 VDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELE---------------------EA 1910
Query: 861 EKSASILDKEINRLRQKIQAEH 882
E+ A I + ++N+LR K + H
Sbjct: 1911 EERADIAESQVNKLRVKSREVH 1932
Score = 71.6 bits (174), Expect = 4e-12
Identities = 150/786 (19%), Positives = 305/786 (38%), Gaps = 126/786 (16%)
Query: 206 KYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLS 265
K K +K+ + E+ + + + E E+TKE++ + E + EL+ + V
Sbjct: 839 KIKPLLKSAETEK---EMANMKEEFEKTKEELAKTEAKRKELEEKMV------------- 882
Query: 266 TMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKY 325
+L E N+++ Q+ A D++ E+R +L + + + ++ E ++
Sbjct: 883 -------TLMQEK-----NDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERA 930
Query: 326 KDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKD----D 381
+D ++ +++ + EC LK D+ + + E + + N+ K L ++ D
Sbjct: 931 EDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD 990
Query: 382 EQLCKRIEE---LKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAI 438
E + K +E L+++ Q+L+ + E K + K ++K + Q+++ + ++
Sbjct: 991 ETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIK--------LEQQVDDLEGSL 1042
Query: 439 EKDKEEHGKIKREELDVKHALSYNQRQLKELKDSK---TDRLKRFGPNVPALLEAIDDAY 495
E++K+ ++R + ++ L Q ++++ K ++LK+ + L I+D
Sbjct: 1043 EQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQ 1102
Query: 496 RQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHAD-ERVLQALMKRFYL 554
G K + L A I + E+ S K Q +D R L+ + +R
Sbjct: 1103 ALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQ------RSDLSRELEEISERLEE 1156
Query: 555 PGTSRPPII------VSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLID---- 604
G + I +EF+ D+ H L D+ ID
Sbjct: 1157 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1216
Query: 605 -------------------MRGIETVLLIKNN--SVARAVMQSQKPPKNCREAFTADGDQ 643
+ETV K N + RA+ K E +
Sbjct: 1217 VKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLIND 1276
Query: 644 VFAGRYYSSENTRPKFLSRDVDSE---ISDLENEVENKTAQILNLQQHL-------SALE 693
+ A R + T SR +D + +S L + T QI L++ L SAL
Sbjct: 1277 LTAQR--ARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALA 1334
Query: 694 ---KDIKHNEELLKRCQLHYKELKMKIRKNISEIR-ELENIEEHQSVDIATLEDEAQENK 749
+ +H+ +LL+ +E K ++++ +S+ E+ D +E +E K
Sbjct: 1335 HALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAK 1394
Query: 750 SKMKM----VEEHMEQQKENMEHLKSLKIEAENKYD--------------AIKFKINQLS 791
K+ EEH+E L+ K +N+ + A+ K
Sbjct: 1395 KKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFD 1454
Query: 792 ELADPLKDELNLADSEVDNQKRGKR-------HYEEKQKEHLDTLNKKKRELDMKEKELE 844
++ K + +E++ ++ R + +E LD L KRE ++E+
Sbjct: 1455 KILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEIS 1514
Query: 845 EKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDRE-EIMRQYQEARETYL 903
+ Q + E+EK +++E + L+ ++ AS E +I+R E +
Sbjct: 1515 DLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKS 1574
Query: 904 DLDSKV 909
++D K+
Sbjct: 1575 EVDRKI 1580
Score = 67.4 bits (163), Expect = 7e-11
Identities = 158/847 (18%), Positives = 347/847 (40%), Gaps = 146/847 (17%)
Query: 168 KEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIM 227
KEEL A + +++ + L QE + LQ + E D L +E ++
Sbjct: 864 KEEL-AKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADS---------LADAEERCDQLI 913
Query: 228 ETKERTKEQIHQGEERLT---ELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVN 284
+TK + + +I + ER E+ + K+ + + S +K +++ L+ +A
Sbjct: 914 KTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDEC--SELKKDIDDLELTLA----- 966
Query: 285 EIEKQLNAIRDNIKIGEDRAARLDR---KMEEQQVRLNEAEQK-YKDIQDKLEKISEETN 340
++EK+ +A + +K + A LD K+ +++ L EA Q+ D+Q + +K++ T
Sbjct: 967 KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTK 1026
Query: 341 ARAP---ECMALKADVVAKKRAYNEAEVLYNRSLNEYKA-------LKKDDEQLCKRIE- 389
A+ + L+ + +K+ + E + + K ++ D +QL ++++
Sbjct: 1027 AKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKK 1086
Query: 390 -ELKKSTDQS-LEPER---LERQKKISWLKERVKAFQN--------------QENSVNQE 430
E + S QS +E E+ ++ QKKI L+ R++ + Q + +++E
Sbjct: 1087 KEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRE 1146
Query: 431 IEQFQQAIEK-----------DKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKR 479
+E+ + +E+ +K+ + ++ D++ A ++ L+ D +
Sbjct: 1147 LEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAE 1206
Query: 480 FGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNH 539
G E ID+ R K + + + D + S KG L+ C
Sbjct: 1207 LG-------EQIDNLQRVKQKLEKEKSEMK--MEIDDLASNMETVSKAKGNLEKMC---- 1253
Query: 540 ADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHP--------DFPTVLTAL 591
R L+ + + +I N++ R R + T+++ L
Sbjct: 1254 ---RALEDQLSEIKTKEEEQQRLI-----NDLTAQRARLQTESGEYSRQLDEKDTLVSQL 1305
Query: 592 EIDNAVVANSLIDM-RGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGD-QVFAGRY 649
+ ++ R +E + K+ ++A A+ S+ RE + + + + R
Sbjct: 1306 SRGKQAFTQQIEELKRQLEEEIKAKS-ALAHALQSSRHDCDLLREQYEEEQEAKAELQRA 1364
Query: 650 YSSENT-----RPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLK 704
S N+ R K+ D +LE + ++ + ++H+ A+ E+ +
Sbjct: 1365 MSKANSEVAQWRTKY-ETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQ 1423
Query: 705 RCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQ--- 761
R Q ++L + + + + L+ + + +A + + +E ++++ ++
Sbjct: 1424 RLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLST 1483
Query: 762 --------QKENMEHLKSLKIEAENKYDAIK----------FKINQLSELADPLKDELNL 803
+E+++ L++LK E +N I +I++L ++ ++ E +
Sbjct: 1484 ELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSE 1543
Query: 804 ADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIE-VEK 862
+ ++ + H E K LN+ K E+D K E +E++ Q ++ I VE
Sbjct: 1544 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKR---NHIRIVES 1600
Query: 863 SASILDKEIN------RLRQKIQAE------HASHGDR--EEIMRQYQEA----RETYLD 904
S LD EI RL++K++ + +H +R E +R Y+ ++T L
Sbjct: 1601 MQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLH 1660
Query: 905 LDSKVRT 911
LD +R+
Sbjct: 1661 LDDALRS 1667
Score = 56.2 bits (134), Expect = 2e-07
Identities = 72/351 (20%), Positives = 156/351 (44%), Gaps = 35/351 (9%)
Query: 142 IQQHISIDGSRSYKLKSATGSVVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSK 201
+ + I+ G R ++L+ V K EL A L+ +++ + + + + Q K
Sbjct: 1516 LTEQIAEGGKRIHELEKIKKQV-EQEKSELQAALEEAEASLEHEEGKILR-IQLELNQVK 1573
Query: 202 NEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSI 261
+E D+ K K +++QMK ++ I+E+ + T + + LK++ +E + I
Sbjct: 1574 SEVDR-KIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKK-MEGDLNEMEI 1631
Query: 262 AGLSTMKTNLESLK-HEMAWAVVNEIEKQLNA-------IRDNIKIGEDRAARLDRKMEE 313
+ E+L+ + A++ + + L+ +++ + + E RA L ++EE
Sbjct: 1632 QLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEE 1691
Query: 314 QQVRLNE-------AEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVL 366
+ L + AEQ+ D ++++ + + + L+ D+ + E E +
Sbjct: 1692 LRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDI---SQIQGEMEDI 1748
Query: 367 YNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENS 426
+ N + KK EELKK D S ER+++ L++ VK Q++ +
Sbjct: 1749 IQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN-----LEQTVKDLQHRLDE 1803
Query: 427 VNQEI-----EQFQQAIEKDKEEHGKIKREE---LDVKHALSYNQRQLKEL 469
Q +Q Q+ + +E G+++ E+ ++ L ++R++KEL
Sbjct: 1804 AEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKEL 1854
Score = 55.1 bits (131), Expect = 4e-07
Identities = 157/873 (17%), Positives = 343/873 (39%), Gaps = 107/873 (12%)
Query: 141 LIQQHISIDGSRSYKLKSATGSVVSTRK-EELIAILDHFNIQVDNPVSVLTQEMSKQF-- 197
L QQ ++GS + K + RK E + + + ++N L +++ K+
Sbjct: 1031 LEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFE 1090
Query: 198 ---LQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEK 254
LQSK E ++ ++++++ + E E + + E++ ++L R+ E
Sbjct: 1091 MSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI 1150
Query: 255 EERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQ 314
ER + G ++ + + + E +K + + E AA L +K +
Sbjct: 1151 SERLEEAGGATSAQIEMNKKREA-------EFQKMRRDLEEATLQHEATAATLRKKHADS 1203
Query: 315 QVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEY 374
L E + ++ KLEK E + L +++ +A E + ++
Sbjct: 1204 VAELGEQIDNLQRVKQKLEKEKSEMKMEIDD---LASNMETVSKAKGNLEKMCRALEDQL 1260
Query: 375 KALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQF 434
+K +E+ + I +L + L+ E E +++ V + + Q+IE+
Sbjct: 1261 SEIKTKEEEQQRLINDLTAQRAR-LQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEEL 1319
Query: 435 QQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDA 494
++ + EE K K + HAL ++ L++ + + A+ +A +
Sbjct: 1320 KRQL----EEEIKAKSA---LAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEV 1372
Query: 495 YRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYL 554
Q Y+ R EL E K L Q A+E V K L
Sbjct: 1373 -AQWRTKYETDAIQ------RTEEL----EEAKKKLAQRL---QDAEEHVEAVNAKCASL 1418
Query: 555 PGTSRPPIIVSEFRNEIYDVRHRAAY-------HPDFPTVLTA----LEIDNAVVANSLI 603
T + + +E + + DV A +F +L E +A + S
Sbjct: 1419 EKTKQR--LQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQK 1476
Query: 604 DMRGIETVLLIKNNSVARAVMQSQ---KPPKNCREAFTADGDQVFAG--RYYSSENTRPK 658
+ R + T L N+ ++ Q + + KN ++ + +Q+ G R + E + +
Sbjct: 1477 ESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQ 1536
Query: 659 FLSR--DVDSEISDLENEVENKTAQILNLQQHLSALEKDI-----KHNEEL--LKRCQLH 709
++ + + + E +E++ +IL +Q L+ ++ ++ + +EE+ +KR +
Sbjct: 1537 VEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIR 1596
Query: 710 YKE-----LKMKIRKNISEIRELENIE------EHQSVDIATLEDEAQEN----KSKMKM 754
E L +IR IR + +E E Q + EA N ++ +K
Sbjct: 1597 IVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKD 1656
Query: 755 VEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRG 814
+ H++ + E LK E + + ++ +I +L + + +A+ E+ +
Sbjct: 1657 TQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASER 1716
Query: 815 KRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQ-------------ICPERIEVE 861
+ + ++T K + ++ + E+E+ + +AR + E ++ E
Sbjct: 1717 VQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKE 1776
Query: 862 KSASI--------LDKEINRLRQKI-QAEH-ASHGDREEIMRQYQEARETYLDLDSK--- 908
+ S L++ + L+ ++ +AE A G +++I + RE +++S+
Sbjct: 1777 QDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKR 1836
Query: 909 -VRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLR 940
V +K K ++ E ++T + + L L+
Sbjct: 1837 NVEAVKGLRKHERKVKELTYQTEEDRKNILRLQ 1869
Score = 54.7 bits (130), Expect = 5e-07
Identities = 72/325 (22%), Positives = 140/325 (43%), Gaps = 47/325 (14%)
Query: 662 RDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNI 721
++V D E TA+ L+ S L+KDI E L + + + K+ KN+
Sbjct: 924 KEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV-KNL 982
Query: 722 SEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYD 781
+E E+ ++E IA L E + + + + ++ +++ + L KI+ E + D
Sbjct: 983 TE--EMAGLDE----TIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVD 1036
Query: 782 AIKFKINQ-------LSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEH------LDT 828
++ + Q L L+ +L LA + + K+ +EK K+ L +
Sbjct: 1037 DLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQS 1096
Query: 829 -----------LNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQK 877
L KK +EL + +ELEE++ R R + EK S L +E+ + ++
Sbjct: 1097 KIEDEQALGMQLQKKIKELQARIEELEEEIEAERA---SRAKAEKQRSDLSRELEEISER 1153
Query: 878 IQ-------AEHASHGDRE-EIMRQYQEARETYLDLDSKVRTLKK----FIKLLGEIMEH 925
++ A+ + RE E + ++ E L ++ TL+K + LGE +++
Sbjct: 1154 LEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDN 1213
Query: 926 RFKTYQQFRRCLTLRCKLYFDNLLS 950
+ Q+ + + K+ D+L S
Sbjct: 1214 LQRVKQKLEKEKS-EMKMEIDDLAS 1237
Score = 39.7 bits (91), Expect = 0.016
Identities = 74/357 (20%), Positives = 139/357 (38%), Gaps = 55/357 (15%)
Query: 665 DSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEI 724
D E + L++E T + + ++ L + I + + + ++ + E+KM+I S +
Sbjct: 1181 DLEEATLQHEATAATLRKKHADS-VAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNM 1239
Query: 725 RELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIK 784
+ + + LED+ E K+K + + + L++ E + D
Sbjct: 1240 ETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKD 1299
Query: 785 FKINQLS-----------ELADPLKDELNLADSEVDNQKRGKRH--------YEEKQKEH 825
++QLS EL L++E+ A S + + + RH YEE+Q+
Sbjct: 1300 TLVSQLSRGKQAFTQQIEELKRQLEEEIK-AKSALAHALQSSRHDCDLLREQYEEEQEAK 1358
Query: 826 LDTLN------------KKKRELD--MKEKELEE---KMSQARQICPERIE-VEKSASIL 867
+ + K E D + +ELEE K++Q Q E +E V + L
Sbjct: 1359 AELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASL 1418
Query: 868 DKEINRLRQKIQAEHASHGDREEIMRQYQEARETYLDLDSKVRTLKKFI---KLLGEIME 924
+K RL+ ++ E++M + LD K R K + K E
Sbjct: 1419 EKTKQRLQNEV----------EDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETH 1468
Query: 925 HRFKTYQQFRRCLT---LRCKLYFDNLLSQRAYCGKMNFDHKNETLSISVQPGEGNK 978
+ Q+ R L+ + K ++ L Q + N + + E ++ Q EG K
Sbjct: 1469 AELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGK 1525
Score = 33.1 bits (74), Expect = 1.5
Identities = 26/90 (28%), Positives = 47/90 (52%), Gaps = 4/90 (4%)
Query: 821 KQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQA 880
K K L + +K +MKE E E+ + + +R E+E+ L +E N L+ ++QA
Sbjct: 839 KIKPLLKSAETEKEMANMKE-EFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQA 897
Query: 881 EHASHGDREEIMRQYQEARETYLDLDSKVR 910
E S D EE + + +T + L++K++
Sbjct: 898 EADSLADAEE---RCDQLIKTKIQLEAKIK 924
Score = 32.0 bits (71), Expect = 3.3
Identities = 31/140 (22%), Positives = 63/140 (45%), Gaps = 14/140 (10%)
Query: 785 FKINQLSELADP------LKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDM 838
FKI L + A+ +K+E E+ + ++ EEK + TL ++K +L +
Sbjct: 838 FKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEK----MVTLMQEKNDLQL 893
Query: 839 KEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQ-E 897
+ + + ++ A + C + I K+ L+ +I + ++ + E + + R+ + E
Sbjct: 894 QVQAEADSLADAEERCDQLI---KTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 950
Query: 898 ARETYLDLDSKVRTLKKFIK 917
E D+D TL K K
Sbjct: 951 CSELKKDIDDLELTLAKVEK 970
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 82.4 bits (202), Expect = 2e-15
Identities = 157/844 (18%), Positives = 342/844 (40%), Gaps = 156/844 (18%)
Query: 164 VSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDY 223
V +K+++ LD IQV + + L ++ S+ + K+ Y+ ++ EQ E
Sbjct: 845 VEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQ--EQT 902
Query: 224 SYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVV 283
I+ KE Q+ +G+++ E+ Q LS + ++ L E
Sbjct: 903 KQILVEKENMILQMREGQKKEIEILTQ------------KLSAKEDSIHILNEEYETKFK 950
Query: 284 NEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLN--------EAEQKYKDIQDKLEKI 335
N+ EK++ ++ K + L +K+ +Q+ +L E QK K K+ ++
Sbjct: 951 NQ-EKKMEKVKQKAK---EMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEM 1006
Query: 336 SEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKAL-KKDDEQLCKRIEELKKS 394
++ +A + ++ + + K++ + EV + R LN+ ++ +K Q + ++E+ +
Sbjct: 1007 AQANSAGISDAVS-RLETNQKEQIESLTEV-HRRELNDVISIWEKKLNQQAEELQEIHEI 1064
Query: 395 TDQSLEPE--------------RLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEK 440
Q E E + E K+I+WLKE N + ++++Q +
Sbjct: 1065 QLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNS 1124
Query: 441 DKEEHGKIKRE----ELDVKHALSYN---QRQLKELKDSKTDRLKRFGPNVPALLEAIDD 493
++ K+K E+D+ +L N Q QL ELK + KR + + L+ D+
Sbjct: 1125 LAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELK-MLAEEDKRKVSELTSKLKTTDE 1183
Query: 494 AYRQGHFTY----KPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALM 549
++ ++ K + ELA+ ++ C K E +L+A
Sbjct: 1184 EFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCK-----------KTEALLEAKT 1232
Query: 550 KRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIE 609
+S+ I+S I +HR ++
Sbjct: 1233 NELINISSSKTNAILSR----ISHCQHRTTK---------------------------VK 1261
Query: 610 TVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEIS 669
LLIK +V+ Q R + E + ++
Sbjct: 1262 EALLIKTCTVSELEAQL---------------------RQLTEEQNTLNISFQQATHQLE 1300
Query: 670 DLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIRELEN 729
+ EN++++ A I +L AL+K+ + ++ + +LK ++ +NI+ + ++
Sbjct: 1301 EKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKE 1360
Query: 730 IEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQ 789
+ + V+I++L + + + + ++ E + SL+ + + + + ++
Sbjct: 1361 ELKEKKVEISSLSKQLTD----LNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQD 1416
Query: 790 LSELADPLKDELNLADSEVDNQKRGKRHYEEKQK----EHLDTLNKKKRELDMKEKELEE 845
LS D L E A +VD+ +++K + +H +T+ + + +L++K KE E
Sbjct: 1417 LSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYE 1476
Query: 846 KMSQARQICPE-----------RIEVEKSASILDKEINRLRQKIQAEHASHGDRE----- 889
K Q + E + E+E S ++K+ + L +++++ A + E
Sbjct: 1477 KDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQ 1536
Query: 890 ---------EIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLR 940
E+++ Y + ++ ++ V+ L+ F + LGE ++R K ++ + LTL
Sbjct: 1537 KTIEIESLNEVLKNYNQQKD--IEHKELVQKLQHF-QELGEEKDNRVKEAEE--KILTLE 1591
Query: 941 CKLY 944
++Y
Sbjct: 1592 NQVY 1595
Score = 81.6 bits (200), Expect = 4e-15
Identities = 168/815 (20%), Positives = 330/815 (40%), Gaps = 126/815 (15%)
Query: 169 EELIAILDHFNIQVDNPVSVLTQ-------------EMSKQFLQSKN-------EGDKYK 208
++L+ L+ N +++ V LTQ E +KQ L K EG K +
Sbjct: 864 QDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKE 923
Query: 209 FFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQS--IAGLST 266
+ TQ KED +I+ + TK E+++ ++K++ E +E + + +
Sbjct: 924 IEI-LTQKLSAKEDSIHILNEEYETK--FKNQEKKMEKVKQKAKEMQETLKKKLLDQEAK 980
Query: 267 MKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYK 326
+K LE+ E++ K L + N D +RL+ +EQ L E + +
Sbjct: 981 LKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHR--R 1038
Query: 327 DIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCK 386
++ D + ++ N +A E + ++E + +K+ E
Sbjct: 1039 ELNDVISIWEKKLNQQAEEL----------------------QEIHEIQLQEKEQE---- 1072
Query: 387 RIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEHG 446
+ ELK+ E+ E K+I+WLKE N + ++++Q + ++
Sbjct: 1073 -VAELKQKI-LLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDET 1130
Query: 447 KIK----REELDVKHALSYN---QRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGH 499
K+K + E+D+ +L N Q QL ELK + KR + + L+ D+ ++
Sbjct: 1131 KLKAHLEKLEVDLNKSLKENTFLQEQLVELK-MLAEEDKRKVSELTSKLKTTDEEFQSLK 1189
Query: 500 FTY----KPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLP 555
++ K + ELA+ ++ C K E +L+A
Sbjct: 1190 SSHEKSNKSLEDKSLEFKKLSEELAIQLDICCK-----------KTEALLEAKTNELINI 1238
Query: 556 GTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIK 615
+S+ I+S I +HR V AL I V+ +R +
Sbjct: 1239 SSSKTNAILS----RISHCQHRTT------KVKEALLIKTCTVSELEAQLRQLTEEQNTL 1288
Query: 616 NNSVARAVMQSQKPPKNC-------------REAFTADG--DQVFAGRYYSSENTRPKFL 660
N S +A Q ++ +EA +G Q A S K L
Sbjct: 1289 NISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKEL 1348
Query: 661 SRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKM-KIRK 719
S ++++ ++ ++ E++ K +I +L + L+ L N +L L KE + +RK
Sbjct: 1349 SENINA-VTLMKEELKEKKVEISSLSKQLTDL------NVQLQNSISLSEKEAAISSLRK 1401
Query: 720 NISEIR-ELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAEN 778
E + EL + + S + TL ++E S ++ V++ + E + +S + +N
Sbjct: 1402 QYDEEKCELLDQVQDLSFKVDTL---SKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQN 1458
Query: 779 KYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDM 838
++ ++ S+ A +++NL E+D Q + + + ++ + KK+ L+
Sbjct: 1459 TVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLET 1518
Query: 839 KEKELEEKMSQAR-QICPERIEVEKSASIL-------DKEINRLRQKIQAEHASHGDREE 890
+ K ++ + I + IE+E +L D E L QK+Q G+ ++
Sbjct: 1519 ELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQ-HFQELGEEKD 1577
Query: 891 IMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEH 925
+ +EA E L L+++V ++K ++ + +EH
Sbjct: 1578 --NRVKEAEEKILTLENQVYSMKAELETKKKELEH 1610
Score = 77.8 bits (190), Expect = 5e-14
Identities = 157/787 (19%), Positives = 324/787 (41%), Gaps = 139/787 (17%)
Query: 216 LEQMKEDYSYIM-ETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESL 274
+EQ+++D ++ ETK + E + EE + +L+ + I ++T L
Sbjct: 355 IEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSR----------IKQMTTQGEELREQ 404
Query: 275 KHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKM-------EEQQVRLNEAEQKYK- 326
K + A E+EK L+ + + A +D ++ EE+++ L + + K
Sbjct: 405 KEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQ 464
Query: 327 DIQDKLEKISEETNARAPEC----MALKADVVAKKRAYNEAE------VLYNRSLNEYKA 376
++ D ++K SEE A+ + +A K + KK E E V +S +EY
Sbjct: 465 EVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLK 524
Query: 377 LKKDDEQ----LCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQ-ENSVNQEI 431
+ ++ EQ + +E KK+ E + + Q++ + R+ ++ E S+ +
Sbjct: 525 ISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENK 584
Query: 432 EQFQQA---IEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSK----TDRLKRFGPNV 484
Q + +E +K +H K ++ + ++ +L+ LK + T++L+
Sbjct: 585 NQSKDLAVHLEAEKNKHNK------EITVMVEKHKTELESLKHQQDALWTEKLQVLKQQY 638
Query: 485 PALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERV 544
+E + + Q T L+D E+ + QA+ +E+
Sbjct: 639 QTEMEKLREKCEQEKETL-----------LKDKEI----------IFQAHI--EEMNEKT 675
Query: 545 LQAL-MKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDF---PTVLTALEIDNAVVAN 600
L+ L +K+ L S SE +E+ RH+ T E++ +
Sbjct: 676 LEKLDVKQTELESLS------SEL-SEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQ 728
Query: 601 SLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFL 660
+ +++++ S+ R ++ K N E + D+ EN
Sbjct: 729 KNHHQQQVDSIIKEHEVSIQRTE-KALKDQINQLELLLKERDKHLKEHQAHVEN------ 781
Query: 661 SRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKEL---KMKI 717
++++I E E++ +A++ Q + SA + K EE L + Q +L ++ +
Sbjct: 782 ---LEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILL 838
Query: 718 RKNISEIRELE-----NIEEHQSVDIATLEDEAQENKSKM--------KMVEEHMEQQKE 764
K ++E+ + ++ H+ + + L + ++ S+M ++ E +E +
Sbjct: 839 TKQVAEVEAQKKDVCTELDAHK-IQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNK 897
Query: 765 NMEHLKSLKIEAENKY----DAIKFKINQLSELADPLKDELNLADSEVD----NQKRGKR 816
E K + +E EN + K +I L++ +D +++ + E + NQ++
Sbjct: 898 EQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKME 957
Query: 817 HYEEKQKEHLDTLNKKKRELDMK-EKELE----EKMSQARQICPERIEVEKSASI-LDKE 870
++K KE +TL KK + + K +KELE E + +Q + +E+ ++ S +
Sbjct: 958 KVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDA 1017
Query: 871 INRL--RQKIQAEHASHGDREEI--------------MRQYQEARETYL-DLDSKVRTLK 913
++RL QK Q E + R E+ + QE E L + + +V LK
Sbjct: 1018 VSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELK 1077
Query: 914 KFIKLLG 920
+ I L G
Sbjct: 1078 QKILLFG 1084
Score = 70.9 bits (172), Expect = 6e-12
Identities = 169/856 (19%), Positives = 333/856 (38%), Gaps = 158/856 (18%)
Query: 146 ISIDGSRSYKLKSATGSVVSTRK---EELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKN 202
+++ S L ++ S RK EE +LD + V L++E Q +
Sbjct: 1379 LNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQ-DLSFKVDTLSKEKISALEQVDD 1437
Query: 203 EGDKYKFFMKATQ--LEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQS 260
+K+ + K Q Q + + E ++ ++ +E++ LK + ++ +RF
Sbjct: 1438 WSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDC 1497
Query: 261 IAG--------LSTMKTNLES-LKHEMAWAV---------------VNEIEKQLNAIRD- 295
+ G + ++NLE+ LK + A + +NE+ K N +D
Sbjct: 1498 LKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDI 1557
Query: 296 NIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVA 355
K + EE+ R+ EAE+K +++++ + E + E + V +
Sbjct: 1558 EHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKS 1617
Query: 356 KKRAYNEAEV-LYNRSLNEYKALKKDDEQLCKRI------------EELKKSTDQ---SL 399
K+ E L + S + LK+ EQ I E+ KK T+ L
Sbjct: 1618 KEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSEL 1677
Query: 400 EPERLERQKKISWLKERVKAFQNQENSV--------------NQEIEQFQQAIEKDKEEH 445
+ ER++++ L+E++K+ ++ ++ QE Q ++K EE
Sbjct: 1678 NTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEK 1737
Query: 446 GKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPV 505
+ + L K L Q KE S ++ L ++ A + H +
Sbjct: 1738 ISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRC---QYQERLIKLEHAEAKQHEDQSMI 1794
Query: 506 GPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVS 565
G L + ++ + +L + A + +QA + + +
Sbjct: 1795 GHLQEELEEKNKKYSLIV---------AQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEK 1845
Query: 566 EFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVARAVMQ 625
E +I + + + E+D+ +V + +E + A M
Sbjct: 1846 ELTCQILEQKIK--------------ELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMD 1891
Query: 626 SQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSR------DVDSEISDLENEVENKT 679
+ P E T + + S +PK LS D++ +++ E E +
Sbjct: 1892 GRNKPTELLEENTEEKSK--------SHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLG 1943
Query: 680 AQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIRELENIE-EHQSVDI 738
+I+ LQ+ L L K+ + E+LK+ +E K+K +E E++E +H S
Sbjct: 1944 KEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIK--------QEQEDLELKHNS--- 1992
Query: 739 ATLEDEAQENKSKMKMVEEHMEQQ-KENMEHLKSLKIEAENKYDAIKFKINQLSELADPL 797
TL+ +E +++ E+ +E KE + K+ ++EAE ++ + + NQL +
Sbjct: 1993 -TLKQLMREFNTQLAQKEQELEMTIKETIN--KAQEVEAE-LLESHQEETNQLLK----- 2043
Query: 798 KDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPER 857
+A+ + D+ KR + YEE + + K R+L + +EL++K
Sbjct: 2044 ----KIAEKD-DDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKK----------- 2087
Query: 858 IEVEKSASILDKEINRLRQKIQAEHASHGDREEIMR-QYQEARETYLDLDSKVRTLKKFI 916
+QK++ E D IM Q Q A++T L DSK++ ++F
Sbjct: 2088 ----------------YQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKE-QEFR 2130
Query: 917 KLLGEIMEHRFKTYQQ 932
+ + +E R K Y++
Sbjct: 2131 EQIHN-LEDRLKKYEK 2145
Score = 69.7 bits (169), Expect = 1e-11
Identities = 178/910 (19%), Positives = 367/910 (40%), Gaps = 144/910 (15%)
Query: 163 VVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKED 222
++ K++L IL + ++ L +E+ K+ +++ LE+ K+
Sbjct: 166 MLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFD-----ASLEE-KDQ 219
Query: 223 YSYIMETK-ERTKEQIHQGEERLTELK--------RQCVEKEERFQS----IAGLSTMKT 269
Y +++T+ K+++ G + LK + KEE +S + T
Sbjct: 220 YISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVK 279
Query: 270 NLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQ 329
LE+L+ V E L ++ I+ +++ L + E Q +L+E Q+ + I+
Sbjct: 280 TLETLQQR-----VKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIK 334
Query: 330 D--KLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKR 387
D EK T R A + ++ ++ V+ ++ L+ +E++ +
Sbjct: 335 DLHMAEKTKLITQLR-------DAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQL 387
Query: 388 IEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVN--QEIEQFQQAIEKDKEEH 445
+K+ T Q E L QK+ K AF+ E +++ Q+ E+ ++ ++ + +E
Sbjct: 388 RSRIKQMTTQG---EELREQKE----KSERAAFEELEKALSTAQKTEEARRKLKAEMDE- 439
Query: 446 GKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDD---AYRQGHFTY 502
+IK E + Q++L +K D +K+ A L+ + + A ++ T
Sbjct: 440 -QIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTK 498
Query: 503 KPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPI 562
K + R+ E ++ L+ Y + E+ ++ L +
Sbjct: 499 K--------LQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELEL----QKKA 546
Query: 563 IVSEFRNEIYDVRHRA-AYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVAR 621
I++E N++ D++ A Y + ++LE N D+ K+N
Sbjct: 547 ILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEIT 606
Query: 622 AVMQSQKPP----KNCREAFTADGDQVFAGRYYSS-ENTRPKFLSRDVDSEISDLENEVE 676
+++ K K+ ++A + QV +Y + E R K + E E
Sbjct: 607 VMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREK----------CEQEKETL 656
Query: 677 NKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIRELEN-IEEHQS 735
K +I+ Q H+ + NE+ L++ + EL+ + +SE+ + + +EE S
Sbjct: 657 LKDKEII-FQAHIEEM------NEKTLEKLDVKQTELE-SLSSELSEVLKARHKLEEELS 708
Query: 736 VDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSELAD 795
V + QE ++KM + H +QQ +++ +K ++ + A+K +INQL L
Sbjct: 709 VLKDQTDKMKQELEAKMDEQKNHHQQQVDSI--IKEHEVSIQRTEKALKDQINQLELLLK 766
Query: 796 PLKDELNLADSEVDNQKRG-KRHYEEKQ-----------------------KEHLDTLNK 831
L + V+N + KR E Q +E L L +
Sbjct: 767 ERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQ 826
Query: 832 KKRELDMKE----KELEEKMSQARQICPE----RIEVEKSASILDKEINRLRQKIQA--- 880
K +L+ + K++ E +Q + +C E +I+V+ L+K+ + + QK+++
Sbjct: 827 KLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQ 886
Query: 881 ---EHASHGDREE------------IMRQYQEARETYLD-LDSKVRTLKKFIKLLGEIME 924
G++E+ ++ Q +E ++ ++ L K+ + I +L E E
Sbjct: 887 VYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYE 946
Query: 925 HRFKTYQQFRRCLTLRCKLYFD----NLLSQRAYCGKMNFDHKNETLSISVQPGEGNKAA 980
+FK ++ + + K + LL Q A K+ + +N L +S + + N
Sbjct: 947 TKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEA---KLKKELENTALELSQKEKQFNAKM 1003
Query: 981 FNDMRALSGG 990
+A S G
Sbjct: 1004 LEMAQANSAG 1013
Score = 57.0 bits (136), Expect = 1e-07
Identities = 137/749 (18%), Positives = 295/749 (39%), Gaps = 142/749 (18%)
Query: 266 TMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKY 325
T + N ++ + A + E E Q+ +++ +I+ L ++ QQ +E E
Sbjct: 1282 TEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCI 1341
Query: 326 KDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRS--LNEYKAL-----K 378
++ +L + E K ++ + + + V S L+E +A K
Sbjct: 1342 TQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRK 1401
Query: 379 KDDEQLCKRIEELKKSTDQSLEPERLERQK------------KIS-WLKERVKAFQNQEN 425
+ DE+ C+ +++++ D S + + L ++K K S W K+ F +N
Sbjct: 1402 QYDEEKCELLDQVQ---DLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQN 1458
Query: 426 SVNQEIEQFQQAIEK--DKEEHGKIKREELDVKH----ALSYNQRQLKELKDSKTDRLKR 479
+V + Q + ++ +K+E + +EELD ++ L K + K L+
Sbjct: 1459 TVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLET 1518
Query: 480 FGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNH 539
+ A + ++D H T K + IES L +L+ Y
Sbjct: 1519 ELKSQTARIMELED-----HITQKTI----------------EIES-LNEVLKNYNQQKD 1556
Query: 540 ADERVLQALMKRFYLPGTSRPPII------VSEFRNEIYDVRHRAAYHPDFPTVLTALEI 593
+ + L ++ F G + + + N++Y ++ + T LE
Sbjct: 1557 IEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMK------AELETKKKELEH 1610
Query: 594 DNAVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPP-------KNCREAFTADGDQVFA 646
N V + +++ +E L ++ S A+ +K K +Q
Sbjct: 1611 VNLSVKSKEEELKALEDRL--ESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKK 1668
Query: 647 GR--YYSSENTRPKFLSRDV---DSEISDLEN----------------------EVENKT 679
G + S NT+ + R+V + ++ +E+ E +++
Sbjct: 1669 GTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQG 1728
Query: 680 AQILNLQQHLSALEKDIKHNEELLKRC--------QLHYKELKMKIRKNISEIRELENIE 731
++ +S L++++ E+LL+R H+ E++ + ++ + ++ E +
Sbjct: 1729 CVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHF-EMRCQYQERLIKLEHAEAKQ 1787
Query: 732 EHQSVDIATLEDEAQE-NKSKMKMVEEHMEQQ--KENMEHLKSLKIEAENKYDAIKFKIN 788
I L++E +E NK +V +H+E++ K N++ ++L EN +D ++ +
Sbjct: 1788 HEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNL----ENVFDDVQKTLQ 1843
Query: 789 QLSELADPLKDELNLADSEVDNQKRGKR--------HYEEKQKEHLDTLNKKKRELDMKE 840
+ L+ ++ DS + QK R YE+ Q L ++ + + ++ E
Sbjct: 1844 EKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQA--LQQMDGRNKPTELLE 1901
Query: 841 KELEEKMSQARQICPERIE---------------VEKSASILDKEINRLRQKIQAEHASH 885
+ EEK S++ + P+ + E+ L KEI RL++ ++ H
Sbjct: 1902 ENTEEK-SKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEH 1960
Query: 886 GDREEIM-RQYQEARETYLDLDSKVRTLK 913
EI+ ++Y + RE + + + LK
Sbjct: 1961 QQELEILKKEYDQEREEKIKQEQEDLELK 1989
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 82.0 bits (201), Expect = 3e-15
Identities = 133/726 (18%), Positives = 293/726 (40%), Gaps = 88/726 (12%)
Query: 198 LQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEER 257
L+ + E K + QLE +++++ +M+ T+E + E+ L L+ E + R
Sbjct: 694 LEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQAR 753
Query: 258 FQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVR 317
+ G E+ E ++ + L A K G++ R R++EE
Sbjct: 754 LGELQG--------EAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEE 805
Query: 318 LNEAEQKYKDI----QDKLEKISEETNARAPECMALKADVVAKK---RAYNEAEVLYNRS 370
+E +K ++ ++E + +ET A + +K + +K AY ++
Sbjct: 806 TSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQL 865
Query: 371 LNEYKALKKD-DEQLCKRIEELKK--STDQSLEPERLERQKKISWLKERVKAFQNQENSV 427
++E KA +K D +L + +EL + ++ E E ++++ +++ + + S
Sbjct: 866 ISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSA 925
Query: 428 NQEIEQFQ---QAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNV 484
+E ++ + Q+++ DKE+ + +K + Q++ ++ + +++R G ++
Sbjct: 926 QKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDL 985
Query: 485 PA------------------LLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIE-S 525
+ L + +A +G L A D LAL
Sbjct: 986 TSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQ 1045
Query: 526 CLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFP 585
L+ LQA E+ LQ ++ TS+ + E R ++ ++ F
Sbjct: 1046 ALEAELQAVSHSKTLLEKELQEVIAL-----TSQE---LEESREKVLELEDELQESRGFR 1097
Query: 586 TVLTALEIDNAVVANSLIDMRGIETVL------LIKNNSVARAVMQSQKPPKNCREAFTA 639
+ LE N +A L +G T L L ++NS+ + +
Sbjct: 1098 KKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKR------------ 1145
Query: 640 DGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHN 699
+ D V + R + R + + L+ +E + ++ +L++ ++A + + HN
Sbjct: 1146 EADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHN 1205
Query: 700 EELLKRCQLHYKELKMK-------IRKNISEIRELENIEEHQSVDIATLEDEAQENKSKM 752
K L E+K + ++K +E +L+ E S +IA + E E ++++
Sbjct: 1206 RRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQL 1265
Query: 753 KMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQK 812
+++++ +++Q S + + + +K++++Q LK +L+L + + +
Sbjct: 1266 QLLQKQLDEQL-------SKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKEL 1318
Query: 813 RGKRHYEEKQK-------EHLDTLNKKKRELDMKEKELEEKMSQARQICPE-RIEVEKSA 864
G + + K E L K K L K EL+ M Q + ++++ + A
Sbjct: 1319 EGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGA 1378
Query: 865 SILDKE 870
+ KE
Sbjct: 1379 AKTRKE 1384
Score = 54.7 bits (130), Expect = 5e-07
Identities = 132/704 (18%), Positives = 276/704 (39%), Gaps = 138/704 (19%)
Query: 285 EIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAP 344
E+ ++ + RD+I + L+ E Q + + ++ ++ +LE +S E +
Sbjct: 378 EVNGEVRSRRDSIC----SSVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALK 433
Query: 345 ECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERL 404
E L+A + A +A+V + S + + + L ++ LK+S LE
Sbjct: 434 EKAELQAQLAALSTKL-QAQVECSHSSQQRQ------DSLSSEVDTLKQSC-WDLERAMT 485
Query: 405 ERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKE-EHGKIKREEL--DVKHALSY 461
+ Q + L+ + + + N + EQ+Q+ + K ++ + + ++ D++ ++
Sbjct: 486 DLQ---NMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTA 542
Query: 462 NQRQLKEL---KDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPE 518
Q QL+++ + + T +LK + +L +++ Y+Q +
Sbjct: 543 LQSQLQQVQLERTTLTSKLKASQAEISSL-QSVRQWYQQ--------------------Q 581
Query: 519 LALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRA 578
LALA E+ ++ LQ H + L++ L S ++ + +HR+
Sbjct: 582 LALAQEARVR--LQGEMAHIQVGQMTQAGLLEHLKLENVS--------LSQQLTETQHRS 631
Query: 579 AYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFT 638
++ + A ++GIE +L + A MQ Q+ E
Sbjct: 632 ------------MKEKGRIAAQ----LQGIEADMLDQE----AAFMQIQEAKTMVEEDLQ 671
Query: 639 ADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKD--- 695
++ + E R L R DS S LE ++E +L Q L AL+++
Sbjct: 672 RRLEE------FEGERER---LQRMADSAAS-LEQQLEQVKLTLLQRDQQLEALQQEHLD 721
Query: 696 -----------IKHNEELLKRCQLHYKELKMKIRKNISEIRELEN---IEEHQSVDIATL 741
++ E+ L Q HY EL+ ++ + E E+ + +++ + +
Sbjct: 722 LMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAA 781
Query: 742 EDEAQENKSKM----KMVEEHMEQQKENM--------------EHLKSLKIEAENKYDAI 783
A+ K ++ + +EE E+ E + EHL+ + + I
Sbjct: 782 LQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKI 841
Query: 784 KFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKE---HLDTLNKKKRELDMKE 840
K + Q + + + + D + K ++ + + KE L ++ +KR + +
Sbjct: 842 KEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAEL 901
Query: 841 KELEEKMSQARQ-----------ICPERIEVEKSASIL--DKEINRLRQKIQAEHASHGD 887
L +++Q RQ ER E+E L DKE Q + A+
Sbjct: 902 SRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKE-----QMVAVTEANEAL 956
Query: 888 REEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQ 931
+++I QEAR+ + K+R L + + M+ + K Y+
Sbjct: 957 KKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYE 1000
Score = 45.4 bits (106), Expect = 3e-04
Identities = 73/410 (17%), Positives = 170/410 (41%), Gaps = 57/410 (13%)
Query: 101 NRGSSLKGFVKDGQNSADISITLRNRGDDAFKA--SVYGNSILIQ---QHISIDGSRSYK 155
++G + G V+ ++S S++L + + + V + ++ + +S++ S++ K
Sbjct: 374 DQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALK 433
Query: 156 LKSATGSVVSTRKEELIAILD--HFNIQ----VDNPVSVLTQ-----EMSKQFLQSKNEG 204
K+ + ++ +L A ++ H + Q + + V L Q E + LQ+ E
Sbjct: 434 EKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEA 493
Query: 205 DKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSI--- 261
L+ +E Y +M E + + + + +L++Q + + Q +
Sbjct: 494 KNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLE 553
Query: 262 -----AGLSTMKTNLESLKHEMAW-----AVVNEIEKQLNAIRDNIKIGEDRAARLDRKM 311
+ L + + SL+ W A+ E +L +I++G+ A L +
Sbjct: 554 RTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHL 613
Query: 312 EEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSL 371
+ + V L++ + + + +E A + ++AD++ ++ A+ + +
Sbjct: 614 KLENVSLSQ------QLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQ--------I 659
Query: 372 NEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEI 431
E K + ++D Q +R+EE + E ERL+R + + + + Q V +
Sbjct: 660 QEAKTMVEEDLQ--RRLEEFEG------ERERLQR------MADSAASLEQQLEQVKLTL 705
Query: 432 EQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFG 481
Q Q +E ++EH + ++ + AL ++ L L+ + R G
Sbjct: 706 LQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLG 755
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 81.3 bits (199), Expect = 5e-15
Identities = 133/795 (16%), Positives = 336/795 (42%), Gaps = 73/795 (9%)
Query: 144 QHISIDGSRSYKLKSATGSVVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNE 203
Q +++ KLKS+ + T+K + L ++ + + L ++ +++ + KN
Sbjct: 281 QEVAVYVQELQKLKSSVNEL--TQKNQT---LTENLLKKEQDYTKLEEKHNEESVSKKNI 335
Query: 204 GDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAG 263
+ K +Q++ S + R ++ + E +LK + E E ++Q +
Sbjct: 336 --QATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKA 393
Query: 264 LSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQ 323
K + + +EI + + + + + + RL + + +L + EQ
Sbjct: 394 EFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQ 453
Query: 324 KYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQ 383
+ D+Q KL ++ E+ + L+ + K+ + E + L + + + + D EQ
Sbjct: 454 QVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQ 513
Query: 384 LCKRIEELKKSTDQSLEPERLERQKKISWLKE-------RVKAFQNQENSVNQEIEQFQQ 436
+ ++I + K Q+LE + ++ IS L++ +++A + + +NQ E+
Sbjct: 514 VLRQIGD-KDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHT 572
Query: 437 AIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYR 496
E+ + K+K + K A Q L + + L+ V +L ++++
Sbjct: 573 LQEQVTQLTEKLKNQSESHKQA----QENLHDQVQEQKAHLRAAQDRVLSLETSVNELNS 628
Query: 497 QGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHAD--ERVLQALMKRFYL 554
Q + + + V L I + EL L+ E+ Q NH D + LQ +
Sbjct: 629 QLNESKEKVSQLDIQIKAKT-ELLLSAEAAKTA--QRADLQNHLDTAQNALQDKQQELNK 685
Query: 555 PGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLI 614
T++ + ++ +++ ++ ++ +LE + + + +++ +
Sbjct: 686 I-TTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEA-DSLEVK 743
Query: 615 KNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSE---ISDL 671
+ A +Q Q+ E R LS+ ++ E +S
Sbjct: 744 ASKEQALQDLQQQRQLNTDLEL-------------------RATELSKQLEMEKEIVSST 784
Query: 672 ENEVENKTAQILNLQQHLSALEKD---IKHN-EELLKRCQLHYKELKMKIRKNISEIREL 727
+++ K+ + +++Q L+ E++ +K + E L + ++ ++EL +I+ ++E++++
Sbjct: 785 RLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKV 844
Query: 728 ENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKEN------------MEHLKSLKIE 775
+ +E +++T++D+ + +K + E++ + E L+++
Sbjct: 845 KMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQ 904
Query: 776 AEN---KYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKK 832
EN + +K + + E + LK ELN ++ + + E+++++ +N+
Sbjct: 905 MENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINEL 964
Query: 833 KRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIM 892
K+ + K+K++E + + ++ E+E L +++ + Q++ AE +
Sbjct: 965 KQSSEQKKKQIEALQGELKIAVLQKTELENK---LQQQLTQAAQELAAEKEK---ISVLQ 1018
Query: 893 RQYQEARETYLDLDS 907
Y++++ET+ L S
Sbjct: 1019 NNYEKSQETFKQLQS 1033
Score = 73.6 bits (179), Expect = 1e-12
Identities = 139/748 (18%), Positives = 301/748 (40%), Gaps = 87/748 (11%)
Query: 215 QLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESL 274
QL++ K+ + ++ T ++ + + L ++ RQ +K+++ Q++ L L+
Sbjct: 482 QLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEAL------LQKS 535
Query: 275 KHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKME-----EQQV-----RLNEAEQK 324
K ++ +EK+ + I+ GE A L++ E ++QV +L +
Sbjct: 536 KEN-----ISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSES 590
Query: 325 YKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQL 384
+K Q+ L +E A A + V++ + + NE N LNE K +
Sbjct: 591 HKQAQENLHDQVQEQKAHL---RAAQDRVLSLETSVNEL----NSQLNESKEKVSQLDIQ 643
Query: 385 CKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEE 444
K EL S + + +R + Q + + ++ Q + N + +++Q ++ DK+E
Sbjct: 644 IKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQ-DKQE 702
Query: 445 HGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLE-AIDDAYRQGHFTYK 503
H L + Q E + + +L+ V A E A+ D +Q
Sbjct: 703 HCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQ---- 758
Query: 504 PVGPLGACIHLRDPELALAIE------SCLKGLLQAYCCHNHADERVLQALMKRFYLPGT 557
L + LR EL+ +E S + LQ + A E + Q L K+
Sbjct: 759 ----LNTDLELRATELSKQLEMEKEIVSSTRLDLQK---KSEALESIKQKLTKQ-----E 806
Query: 558 SRPPIIVSEFRNEIYDVR-HRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKN 616
I+ +F + + + T +T L+ + ++ ++ L +
Sbjct: 807 EEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVS 866
Query: 617 NSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEIS-DLENEV 675
+S+ + + +K + + A D ++ + + L + + S + E E
Sbjct: 867 DSLKNSKSEFEKENQKGKAAIL-DLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEA 925
Query: 676 ENKTAQILN-LQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIRELENIEEHQ 734
++ LN +Q+ L + +K NE+ ++ Q + ELK + +I L+ +
Sbjct: 926 SHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIA 985
Query: 735 SVDIATLEDEAQEN-----------KSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAI 783
+ LE++ Q+ K K+ +++ + E+ +E + L+S E++ A
Sbjct: 986 VLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLAT 1045
Query: 784 KFKINQLSELADPLKDELNLADSEVDNQKR--------------GKRHYEEKQKEHLDTL 829
+ + + E +++L +++ NQ + E++ +E L
Sbjct: 1046 RQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKAL 1105
Query: 830 NKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDRE 889
++E +KEKEL + S+ +I + EK + L++E+ + + E + D +
Sbjct: 1106 QDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAK 1165
Query: 890 EIMRQYQEARETYLDLDSKVRTLKKFIK 917
+++ Q + L+L K +LK ++
Sbjct: 1166 QLLIQQK------LELQGKADSLKAAVE 1187
Score = 71.6 bits (174), Expect = 4e-12
Identities = 165/856 (19%), Positives = 338/856 (39%), Gaps = 136/856 (15%)
Query: 181 QVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQG 240
Q+ L +++++ + KN+ + +K + +Q++E +++ ++R
Sbjct: 565 QLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLH-DQVQEQKAHLRAAQDRVLSL---- 619
Query: 241 EERLTELKRQCVEKEERFQSIAGLSTMKTNL----ESLKHEMAWAVVNEIEKQLNAIRDN 296
E + EL Q E +E+ + KT L E+ K + N ++ NA++D
Sbjct: 620 ETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK 679
Query: 297 IKIGEDRAARLDR---KMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADV 353
+ +LD+ K++++Q ++ E K+ ++K + ++T + L+AD
Sbjct: 680 QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADS 739
Query: 354 VAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKK---I 410
+ K + +A + L + + L D E + + + + + RL+ QKK +
Sbjct: 740 LEVKASKEQAL----QDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEAL 795
Query: 411 SWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEHG-----------KIKREELDVKHAL 459
+K+++ + ++ + Q+ E Q + EE K+K E+ + L
Sbjct: 796 ESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTEL 855
Query: 460 SYNQRQLKE----LKDSKTDRLKRFGPNVPALLEAIDDAYRQGHF-------TYKPVGPL 508
S + +L + LK+SK++ K A+L+ H T K L
Sbjct: 856 STVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKEL 915
Query: 509 GACIHLRDP---ELALAIESCLKGLLQAYCC--HNHADERVLQALMKRFYLPGTSRPPII 563
+ +L L + S + L+QA N +E+ LQ + + I
Sbjct: 916 KKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQI 975
Query: 564 VSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAV------VANSLIDMRGIETVLLIKNN 617
+ + E+ VL E++N + A L + E + +++NN
Sbjct: 976 EA-LQGELKIA------------VLQKTELENKLQQQLTQAAQELAAEK--EKISVLQNN 1020
Query: 618 SVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVEN 677
+SQ+ K + F ++ A R L+++ ++ N++ N
Sbjct: 1021 -----YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQE---DLISNRNQIGN 1072
Query: 678 KTAQILNLQQHLSALEKD-IKHNEELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSV 736
+ I L+ + LE+D K ++L +RC + L++I++ +S+
Sbjct: 1073 QNKLIQELKTAKATLEQDSAKKEQQLQERC------------------KALQDIQKEKSL 1114
Query: 737 DIATLEDEAQENKSKMKMVEEHMEQQKENM----EHLKSLKIEA---------------- 776
E E KSK+ +EE +Q++ + E LKS K+E+
Sbjct: 1115 K----EKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQ 1170
Query: 777 -----ENKYDAIKFKINQLSELADPLKDELNLADSEVDN---QKRGKRHYEEKQKE-HLD 827
+ K D++K + Q LKD++ + E+ +K K H E K+KE +
Sbjct: 1171 QKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMK 1230
Query: 828 TLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHA---- 883
+ + +L M+ L E + ++ E ++ S L+K+ + LR +I A
Sbjct: 1231 KHEENEAKLTMQITALNENLGTVKK---EWQSSQRRVSELEKQTDDLRGEIAVLEATVQN 1287
Query: 884 SHGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQ--QFRRCLTLRC 941
+ +R ++ + + L +KV L++ + ++ + Q Q + L
Sbjct: 1288 NQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNR 1347
Query: 942 KLYFDNLLSQRAYCGK 957
K DN + CGK
Sbjct: 1348 KWAEDNEVQNCMACGK 1363
Score = 65.9 bits (159), Expect = 2e-10
Identities = 126/712 (17%), Positives = 273/712 (38%), Gaps = 89/712 (12%)
Query: 273 SLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKL 332
SLK E ++ E++K+L + + + A+ D + + L EQ+ ++ Q +
Sbjct: 98 SLKEEKWYS--EELKKELEKYQGL----QQQEAKPDGLVTDSSAELQSLEQQLEEAQTEN 151
Query: 333 EKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELK 392
I + + + L ++ K Y+E L + + L ++ + I++LK
Sbjct: 152 FNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLK 211
Query: 393 KSTDQS-------------------LEPERLERQKKISWLKERVKAFQNQENSVNQEIEQ 433
Q ++ LER+++ LK+ K Q+Q S I Q
Sbjct: 212 TELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQ 271
Query: 434 FQQAIEKDKEEHG----KIKREELDVKHALSYNQRQLKELKDSKTDRLKR---------F 480
+ + K +E ++++ + V NQ + L + D K
Sbjct: 272 LRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVS 331
Query: 481 GPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNH- 539
N+ A L D +Q IH+ E A + + L + + H
Sbjct: 332 KKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHL 391
Query: 540 -ADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVV 598
A+ + LQ + G + ++EI + + L E
Sbjct: 392 KAEFKQLQQQREEKEQHGL--------QLQSEINQLHSK----------LLETERQLGEA 433
Query: 599 ANSLIDMRGIETVLLI-KNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRP 657
L + R + + L+ K VA ++ + + +E T + ++
Sbjct: 434 HGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQ 493
Query: 658 KFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKI 717
+ L + +++ + +N++E QI + Q + LE ++ ++E + + ++L KI
Sbjct: 494 QALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKI 553
Query: 718 RKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENM----EHLKSLK 773
+ E L ++E TL+++ + K+K E +Q +EN+ + K+
Sbjct: 554 QAGEGETAVLNQLQEKNH----TLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHL 609
Query: 774 IEAENKYDAIKFKINQLSELADPLKDELNLADSEVD-------NQKRGKRHYEEKQKEHL 826
A+++ +++ +N+L+ + K++++ D ++ + + K + HL
Sbjct: 610 RAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHL 669
Query: 827 DT-----------LNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLR 875
DT LNK +LD +L++K Q+ E ++ L+++ L
Sbjct: 670 DTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELE 729
Query: 876 QKIQAEHAS----HGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIM 923
+I+ A +E+ ++ Q+ R+ DL+ + L K +++ EI+
Sbjct: 730 GQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIV 781
Score = 64.3 bits (155), Expect = 6e-10
Identities = 136/773 (17%), Positives = 309/773 (39%), Gaps = 63/773 (8%)
Query: 191 QEMSKQFLQSKNEGDKYK-----FFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLT 245
Q + +Q +++ E K F KA QL D + + +E Q RLT
Sbjct: 138 QSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLT 197
Query: 246 ELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAA 305
E E + + +KT L AV+ + Q+ + DN+ + +R +
Sbjct: 198 E---------ELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERES 248
Query: 306 -RLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAE 364
+L + ++ Q + +E ++ +L K +E E LK+ V NE
Sbjct: 249 EKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSV-------NEL- 300
Query: 365 VLYNRSLNEYKALKKDD----EQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAF 420
N++L E K+ D E+ KK+ +L + L+ Q+ L+ R+ A
Sbjct: 301 TQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQ----LQSRLSAS 356
Query: 421 QNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRF 480
+ + ++ E+ + +A +K KEE +++ + +K Q+Q +E +
Sbjct: 357 ETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEI 416
Query: 481 GPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALA--------IESCLKGLLQ 532
LLE + + H K L + L D E +A +E LK +
Sbjct: 417 NQLHSKLLET-ERQLGEAHGRLKEQRQLSS-EKLMDKEQQVADLQLKLSRLEEQLKEKVT 474
Query: 533 AYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALE 592
H ++ Q ++ L ++ + E +N++ V + L AL
Sbjct: 475 NSTELQHQLDKTKQQHQEQQALQQSTTAKL--REAQNDLEQVLRQIGDKDQKIQNLEAL- 531
Query: 593 IDNAVVANSLIDMRGIETVLLIKNNSVARAVM-QSQKPPKNCREAFTADGDQVFAGRYYS 651
+ + SL++ + I+ AV+ Q Q+ +E T +++
Sbjct: 532 LQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKL------K 585
Query: 652 SENTRPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYK 711
+++ K ++ ++ + + + ++L+L+ ++ L + ++E + + + K
Sbjct: 586 NQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIK 645
Query: 712 -ELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQE-NK---------SKMKMVEEHME 760
+ ++ + ++ + +++ H L+D+ QE NK +K++ +EH
Sbjct: 646 AKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCS 705
Query: 761 QQKENMEHLKSLKIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEE 820
Q + +++ K + E K + ++ +I +L + +K A ++ Q++ E
Sbjct: 706 QLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLEL 765
Query: 821 KQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQA 880
+ E L +K + +L++K I + + E+ IL ++ L Q+ +
Sbjct: 766 RATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKI 825
Query: 881 EHASHGDR-EEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQ 932
+H +R + + + Q+ + L +++ T+K + + + +++ +++
Sbjct: 826 QHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEK 878
Score = 58.2 bits (139), Expect = 4e-08
Identities = 83/442 (18%), Positives = 182/442 (41%), Gaps = 66/442 (14%)
Query: 147 SIDGSRS-YKLKSATGSVVSTRKEELIAILDH-FNIQVDNPVSVLTQEMSKQFLQSKNEG 204
S+ S+S ++ ++ G E+ L H +Q++N + +E+ K + K
Sbjct: 868 SLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKE-QKELKKSLEKEKEAS 926
Query: 205 DKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAG- 263
+ K +L M+E T ++ +++ Q + + ELK+ +K+++ +++ G
Sbjct: 927 HQLKL-----ELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGE 981
Query: 264 ---LSTMKTNLESLKHEMAWAVVNEI---EKQLNAIRDNIKIGEDRAARLDRKMEEQQVR 317
KT LE+ + E+ +++++ +++N + ++ +L ++
Sbjct: 982 LKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESE 1041
Query: 318 LNEAEQKYKDIQDKLEKISEET----------NARAPECMALKA----DVVAKKRAYNEA 363
L Q K +++KL E+ N E KA D K++ E
Sbjct: 1042 LLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQER 1101
Query: 364 -----EVLYNRSL------NEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISW 412
++ +SL NE L + +E C++ +E+ K ++ L+ +LE K+I+
Sbjct: 1102 CKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEE-LKSHKLESIKEITN 1160
Query: 413 LKERVKAFQNQENSVNQEIEQFQQAIEKDKEEH----GKIKREELDVKHALSYNQRQL-K 467
LK+ + Q+ + + + + A+E++K ++K+EE ++K + +L
Sbjct: 1161 LKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHS 1220
Query: 468 ELKDSKTDRLK------RFGPNVPALLEAIDDAYRQGHFTYKPVGP-------------- 507
E+K+ + K + + AL E + ++ + + V
Sbjct: 1221 EIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAV 1280
Query: 508 LGACIHLRDPELALAIESCLKG 529
L A + E +E CLKG
Sbjct: 1281 LEATVQNNQDERRALLERCLKG 1302
Score = 32.7 bits (73), Expect = 1.9
Identities = 50/243 (20%), Positives = 97/243 (39%), Gaps = 47/243 (19%)
Query: 672 ENEVENKTAQILNLQQHLSALEKDIK----HNEELLKRCQLHYKELKMKIRKNISEIREL 727
E+ + K + L+Q + L+ +K ++EEL K + Y+ L+ + K
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELE-KYQGLQQQEAKP------- 126
Query: 728 ENIEEHQSVDIATLE---DEAQENKSKMKMVEEHMEQQ-----------KENMEHLKSLK 773
+ + S ++ +LE +EAQ +K +++ EQ+ K + +SL+
Sbjct: 127 DGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLR 186
Query: 774 IEAENKYDAIKFKINQLSELADPLKDEL----NLADSEV------------DNQKRGKRH 817
AE K + ++N+ + + LK EL + D V DN +
Sbjct: 187 EAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERER 246
Query: 818 YEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEV-EKSASILDKEINRLRQ 876
EK K+ L + + +L ++++ P+ + V + L +N L Q
Sbjct: 247 ESEKLKDECKKLQSQYASSEATISQLRSELAKG----PQEVAVYVQELQKLKSSVNELTQ 302
Query: 877 KIQ 879
K Q
Sbjct: 303 KNQ 305
>gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens]
Length = 1233
Score = 80.5 bits (197), Expect = 8e-15
Identities = 85/457 (18%), Positives = 210/457 (45%), Gaps = 37/457 (8%)
Query: 45 VGIIESIHLKNFMCHS---MLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGRAVATN 101
+G ++ I ++NF + ++GPF+ ++G NGSGKS ++ A+ LG + +
Sbjct: 1 MGFLKLIEIENFKSYKGRQIIGPFQ---RFTAIIGPNGSGKSNLMDAISFVLGEK-TSNL 56
Query: 102 RGSSLKGFVKDGQNSADISITLRNRGDDAFKASVYGNSILIQQHISIDGSRSYKLKSATG 161
R +L+ + + A + NR + S G + + GS YK+ +
Sbjct: 57 RVKTLRDLI----HGAPVGKPAANRAFVSMVYSEEGAEDRTFARVIVGGSSEYKINNKVV 112
Query: 162 SVVSTRKE-ELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMK 220
+ +E E + IL I+ N L + + + + KN ++ F + ++ ++
Sbjct: 113 QLHEYSEELEKLGIL----IKARN---FLVFQGAVESIAMKNPKERTALFEEISRSGELA 165
Query: 221 EDY----SYIMETKERTKEQIHQGEERLTELKRQCVEKEE--RFQSIAG-LSTMKTNLES 273
++Y +++ +E T+ H+ + E K EKEE R+Q + + + L+
Sbjct: 166 QEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQL 225
Query: 274 LKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLE 333
K + ++ K+L + I+ + R +++ +++E++ L + ++ + I+ +++
Sbjct: 226 FKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIK 285
Query: 334 KISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKR---IEE 390
+ E N + P+ + K + K + A+ + YK K D ++L K +E+
Sbjct: 286 EKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEK 345
Query: 391 LKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVN-------QEIEQFQQAIEKDKE 443
++ ++ +E E + + ++ + +VK + + + QE+E+F + + D++
Sbjct: 346 ARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQD 405
Query: 444 EHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRF 480
+R++++ + + R+++E + ++L+ +
Sbjct: 406 RLDLEERKKVETEAKIKQKLREIEE-NQKRIEKLEEY 441
Score = 75.1 bits (183), Expect = 3e-13
Identities = 184/964 (19%), Positives = 393/964 (40%), Gaps = 162/964 (16%)
Query: 191 QEMSKQFLQSKN---EGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTEL 247
++++K+ L SKN E DK + +L++ K++ +M +++ +++I + + L +
Sbjct: 236 EKLNKE-LASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQK 294
Query: 248 KRQCVE-KEERFQSIAGLSTMKTNLESLK--HEMAWAVVNEIEKQLNAIRDNIKIGEDRA 304
+ Q ++ KE I L K +L++ + ++ ++E+EK++ ++ + E+R
Sbjct: 295 RPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERM 354
Query: 305 AR------LDRKMEEQQVRL-----NEAEQKYKDIQDKLEKISEETNARAPECMALKADV 353
D +EE QV+ EA ++ + +LEK + + A + D+
Sbjct: 355 EEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQD-----RLDL 409
Query: 354 VAKKRAYNEAEVLYN----------------------RSLNEYKALK----KDDEQLCKR 387
+K+ EA++ +SL E K L+ ++ E +R
Sbjct: 410 EERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRR 469
Query: 388 IEELKKSTDQSLEP--------ERLERQKKISWLKERVKAF-----------------QN 422
I+E+ K +Q +E + RQ++ + + E +K +
Sbjct: 470 IDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKK 529
Query: 423 QENSVNQEIEQFQQAIEKDKEEHG-------KIKREELDVKHALSY-----NQRQLKELK 470
+ +V + + + AI D E+ G K +R E + L Y +L+ELK
Sbjct: 530 YQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELK 589
Query: 471 DSKT--DRLKRFGPNVPALLEA----------IDDAYR---QGHFTYKPVGPLGACIHLR 515
+K D ++ P++ L+ ++DA R GH +K V G
Sbjct: 590 GAKLVIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKS 649
Query: 516 DPELALAIESCLKGLL---QAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIY 572
A + K +A ER+ + L ++ R + + +++ +
Sbjct: 650 GVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMK---AKRKEAELRQVQSQAH 706
Query: 573 DVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLI---KNNSVARAVMQSQKP 629
++ R Y + +A +L + +E+ L + N + R + ++
Sbjct: 707 GLQMRLKYSQS-----DLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSRERE 761
Query: 630 PKNCREAFTADGDQVFAG--RYYSSENTRPKFLSRDVDSEISDLENEVENKTAQILNLQQ 687
K+ +E D+VF R N R + + E +NE+ K + N +
Sbjct: 762 MKDLKEKMNQVEDEVFEEFCREIGVRNIR------EFEEEKVKRQNEIAKKRLEFENQKT 815
Query: 688 HLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIRELENIEE-HQSV---DIATLED 743
L ++ D + N+ LK Q + ++K+ +EI +L+ E+ H + +A L+D
Sbjct: 816 RLG-IQLDFEKNQ--LKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQD 872
Query: 744 ----------EAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSEL 793
E + +M+ + + + + M HL+ E K + + + L +
Sbjct: 873 LKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQA 932
Query: 794 ADPLKDELNLADSEVDN--QKRGKRHYEEKQK--EHLDTLNKKKRELDMKEKELEEKMSQ 849
+L L+ +D+ Q+ G E+ + + ++ ++ +++ +L E +
Sbjct: 933 CKMQDIKLPLSKGTMDDISQEEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKD 992
Query: 850 ARQICPERIEVEKSASILDKEINRLR---QKIQAEHASHGDREEIMRQYQEARETYLDLD 906
A+ E+++ + L +++N + Q+I A + ++ E +R + +ET + +
Sbjct: 993 AQA----EEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRD--KFQETSDEFE 1046
Query: 907 SKVRTLKKFIKLLGEIMEHRFKTYQQ-FRRCLTLRCKLY--FDNLLSQRAYCGKMNFDHK 963
+ + KK + +I + RF + F T ++Y S +A+ G N +
Sbjct: 1047 AARKRAKKAKQAFEQIKKERFDRFNACFESVATNIDEIYKALSRNSSAQAFLGPENPEEP 1106
Query: 964 N-ETLSIS-VQPGEGNKAAFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYM 1021
+ ++ + V PG+ F M LSGGE++ + + + ++ S +PF LDE D +
Sbjct: 1107 YLDGINYNCVAPGK----RFRPMDNLSGGEKTVAALALLFAIHSYKPAPFFVLDEIDAAL 1162
Query: 1022 DMVN 1025
D N
Sbjct: 1163 DNTN 1166
Score = 63.2 bits (152), Expect = 1e-09
Identities = 62/277 (22%), Positives = 120/277 (43%), Gaps = 18/277 (6%)
Query: 642 DQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEE 701
++ F YS E + +R + S E ++ NK Q+ + L L IK
Sbjct: 76 NRAFVSMVYSEEGAEDRTFARVIVGGSS--EYKINNKVVQLHEYSEELEKLGILIKARNF 133
Query: 702 LLKRCQLHYKELK-----MKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMV- 755
L+ + + +K + + IS EL + + ++ E++ Q N + K +
Sbjct: 134 LVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIA 193
Query: 756 --EEHMEQQKENMEHLKSLKIEAENKYDAIK-FKINQLSELADPLKDELNLADSEVDNQK 812
+ +Q+KE + + LK E ++ FK+ + L EL + E++ K
Sbjct: 194 AERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDK 253
Query: 813 RGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEIN 872
+ E++ KE L K RE EKE++EK S+ Q P+ I+ +++ S K++
Sbjct: 254 KRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLE 313
Query: 873 RLRQKIQAEHASH----GDREEI---MRQYQEARETY 902
++ +Q + GD +E+ M ++AR+ +
Sbjct: 314 AAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEF 350
Score = 31.2 bits (69), Expect = 5.6
Identities = 23/107 (21%), Positives = 51/107 (47%), Gaps = 6/107 (5%)
Query: 390 ELKKSTDQSLEPERLERQK-KISWLKERVKAFQNQENSV-----NQEIEQFQQAIEKDKE 443
E K++ + E +R +R K ++ + +++ F+ N V N+E+ + IEKDK+
Sbjct: 195 ERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKK 254
Query: 444 EHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEA 490
K++ E + K L R+ ++++ ++ P ++A
Sbjct: 255 RMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKA 301
>gi|82880656 coiled-coil domain containing 46 isoform a [Homo
sapiens]
Length = 955
Score = 78.6 bits (192), Expect = 3e-14
Identities = 164/790 (20%), Positives = 318/790 (40%), Gaps = 117/790 (14%)
Query: 176 DHFNIQV-DNPVSVLTQEMSKQF------LQSKNEGDKYKFF-MKATQLEQMKEDYSYIM 227
DHF ++ + + + T+ M +F LQ K++ D K K ++E++K Y
Sbjct: 246 DHFLSRIREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYR--- 302
Query: 228 ETKERTKEQIHQGEERLTELKRQC-VEKEERFQSIAGLSTM-KTNLESLKHEMAWAVVNE 285
+ T+E I + E+++ L R C V +E + IA L + + + ESL N+
Sbjct: 303 SKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLN--------ND 354
Query: 286 IEKQL-NAI----RDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETN 340
EK+L NA+ ++ + + + +E+ VRLN+ E +Y + +E
Sbjct: 355 WEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELE 414
Query: 341 ARAPECM--ALKADVVAKKRAYNEAEV--LYNRSLNEYKALKKDDEQLCKRIEELKKSTD 396
AR + A +++ +K +AE+ Y + +E + +K L K + L +
Sbjct: 415 ARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYE 474
Query: 397 QSLEPERLERQKKISWLKERVKAFQNQENSVNQEIE----QFQQAIEKD--------KEE 444
Q+++ + + I+ LK+ ++ +S+ +E+E Q +Q +++ +++
Sbjct: 475 QNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQ 534
Query: 445 HGKIKREELDVKHALSYNQRQLK-ELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYK 503
K + E+ +KH L+ EL K D K+ AL E + R
Sbjct: 535 ENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRL 594
Query: 504 PVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPII 563
A + ++ L E + Y E+V L + L
Sbjct: 595 QAQQADAALEEFKRQVELNSE-------KVYAEMKEQMEKVEADLTRSKSLREKQS---- 643
Query: 564 VSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVARAV 623
EF ++ D+R R + + L++++ L+ E L++++
Sbjct: 644 -KEFLWQLEDIRQR------YEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIEN 696
Query: 624 MQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQIL 683
++ Q N EN +F RD I+D+E +V +++
Sbjct: 697 LEKQLRAANMEH-----------------ENQIQEFKKRDA-QVIADMEAQVHKLREELI 738
Query: 684 NL--QQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATL 741
N+ Q+ +E + EE + + H E+ + K SE ++E + H + TL
Sbjct: 739 NVNSQRKQQLVELGLLREEEKQRATREH--EIVVNKLKAESEKMKIELKKTHAAETEMTL 796
Query: 742 EDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSELADPLKDEL 801
E + SK+K +E+ Q+ KS +I AE L LK+E
Sbjct: 797 E----KANSKLKQIEKEYTQKL-----AKSSQIIAE------------LQTTISSLKEEN 835
Query: 802 NLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVE 861
+ + + + R E +K+ L + + + + + ELE + +Q R C E+ +++
Sbjct: 836 SQQQLAAERRLQDVRQKFEDEKKQL--IRDNDQAIKVLQDELENRSNQVR--CAEK-KLQ 890
Query: 862 KSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLLGE 921
++I +RQ+ + + G +R QE +T L S+V L+K
Sbjct: 891 HKELESQEQITYIRQEYETK--LKGLMPASLR--QELEDTISSLKSQVNFLQK----RAS 942
Query: 922 IMEHRFKTYQ 931
I++ TYQ
Sbjct: 943 ILQEELTTYQ 952
Score = 52.0 bits (123), Expect = 3e-06
Identities = 139/730 (19%), Positives = 287/730 (39%), Gaps = 101/730 (13%)
Query: 114 QNSADISITLRNRGDDAFKASVYGNSILIQQHISIDGSRSYKLKSAT----GSVVSTRKE 169
++ AD+ L + ++ + S +QH + + R + K T V+ KE
Sbjct: 278 KHDADVQKILERKNNEIEELKTLYRS---KQHETEETIRKLEKKVQTLIRDCQVIRETKE 334
Query: 170 ELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMET 229
+ IA L + L + K+ + E ++ KF ++ E ++E + +T
Sbjct: 335 DQIAELKKI---CEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQE---LLEDT 388
Query: 230 KERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQ 289
R + + + E E R Q + G +NL+ K A E+E+
Sbjct: 389 NVRLNKMESEYMAQTQSTNHMIKELEARVQQLTG-EAENSNLQRQKLIQEKA---ELERC 444
Query: 290 LNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEK----ISEETNARAPE 345
+ ++ AR + +E+ +N+ EQ K +Q K + + +E A +
Sbjct: 445 YQITCSEL---QEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASK 501
Query: 346 CMA----LKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQS-LE 400
+ L+ +V K+ E+E+ + L + + + ++ K I E K QS L+
Sbjct: 502 ASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELD 561
Query: 401 PERLERQKKISWLKERVKAFQNQENSVNQ-----------EIEQFQQAIEKDKEE----- 444
+ + QKKI +E +K + Q V + +E+F++ +E + E+
Sbjct: 562 KGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEM 621
Query: 445 HGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKP 504
++++ E D+ + S ++Q KE D +R+ + L ++ + H +
Sbjct: 622 KEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVEL--KLEHEQEKTHLLQQH 679
Query: 505 VGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIV 564
+ + + E IE+ K L A N E +Q K R ++
Sbjct: 680 NAEKDSLVRDHERE----IENLEKQLRAA----NMEHENQIQEFKK--------RDAQVI 723
Query: 565 SEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVARAVM 624
++ +++ +R + + NS + +E LL + RA
Sbjct: 724 ADMEAQVHKLR------------------EELINVNSQRKQQLVELGLL-REEEKQRATR 764
Query: 625 QSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQ--- 681
+ + + ++ +E T K +S++ +E E K A+
Sbjct: 765 EHEIVVNKLKAESEKMKIELKKTHAAETEMTLEK-----ANSKLKQIEKEYTQKLAKSSQ 819
Query: 682 -ILNLQQHLSALEKDIKHNEELLKR-----CQLHYKELKMKIRKNISEIRELENIEEHQS 735
I LQ +S+L+++ + +R Q E K IR N I+ L++ E++S
Sbjct: 820 IIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRS 879
Query: 736 VDIATLEDEAQ----ENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLS 791
+ E + Q E++ ++ + + E + + + SL+ E E+ ++K ++N L
Sbjct: 880 NQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMP-ASLRQELEDTISSLKSQVNFLQ 938
Query: 792 ELADPLKDEL 801
+ A L++EL
Sbjct: 939 KRASILQEEL 948
Score = 46.2 bits (108), Expect = 2e-04
Identities = 59/259 (22%), Positives = 107/259 (41%), Gaps = 34/259 (13%)
Query: 657 PKFLSRDVDSEISD------LENEVENKTAQILNLQQHLSALEKDIKHN---EELLKRCQ 707
PKF R S D E E++ KT +++ + H L+ KH+ +++L+R
Sbjct: 233 PKFSLRKSSSFHDDHFLSRIREKELDMKT-KMMEAKFHEEKLKLQQKHDADVQKILERKN 291
Query: 708 LHYKELKMKIRKNISE----IRELEN-----IEEHQSVDIATLEDEAQENKSKMKMVEEH 758
+ELK R E IR+LE I + Q + T ED+ E K + E
Sbjct: 292 NEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIR-ETKEDQIAELKKICEQSTES 350
Query: 759 MEQQKENMEHLKSLKIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHY 818
+ E H ++E E K+D K + EL + LN +SE Q + H
Sbjct: 351 LNNDWEKKLHNAVAEMEQE-KFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHM 409
Query: 819 EEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKI 878
++ + + L E E Q +++ E+ E+E+ I E+ ++ +
Sbjct: 410 IKELEARVQQLT----------GEAENSNLQRQKLIQEKAELERCYQITCSELQEVKAR- 458
Query: 879 QAEHASHGDREEIMRQYQE 897
+ H +++ ++ Y++
Sbjct: 459 --RNTLHKEKDHLVNDYEQ 475
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 77.0 bits (188), Expect = 9e-14
Identities = 134/715 (18%), Positives = 286/715 (40%), Gaps = 87/715 (12%)
Query: 228 ETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVV--NE 285
E + +++++ EE L+ + E E++ +S+ T LE E+ +
Sbjct: 440 EESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSV------NTRLEKTAKELEEEITLRKS 493
Query: 286 IEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPE 345
+E L + + + + A RK + + + E ++D+LE + + R
Sbjct: 494 VESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKK----RNQN 549
Query: 346 CMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLE 405
V +R +E L + L+K + K+I++L+ + + L
Sbjct: 550 SQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLL 609
Query: 406 RQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHA------L 459
K+ KE F N ++++ E E + G+I E D+K+ +
Sbjct: 610 ETAKLKLEKE----FINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKV 665
Query: 460 SYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPEL 519
+RQL+E ++ L+ I + Q +K A + +
Sbjct: 666 ELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESI 725
Query: 520 ALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFR------NEIY- 572
A +K + + +ER L+ ++ L R ++ + + NE+
Sbjct: 726 EEAKSEAMKEMEKKLL-----EERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLK 780
Query: 573 -------DVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVARAVMQ 625
DVR+ + D + + ++ E L +NN + M
Sbjct: 781 QKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMN 840
Query: 626 SQKPPKNCR-EAFTADG------DQVFAGRYYSS-----------ENTRPKFLSRDVDSE 667
+K R E ADG DQ+ A +Y+S+ E L +++ +
Sbjct: 841 LEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQK 900
Query: 668 ISDLENEVENKTAQIL---------NLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIR 718
+L++E ++ AQ+ L + ++ + E+++K +L KE+ + +
Sbjct: 901 KQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMK--ELEIKEMMARHK 958
Query: 719 KNISE----IRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKI 774
+ ++E I LE + D+A L +E +E +K+K V+E + + K+ ++K
Sbjct: 959 QELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKA 1018
Query: 775 EAENKY---DAIKFK-INQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLN 830
+ E + +K + +N+L+E+ + + D++V +R +E +K H++ +
Sbjct: 1019 QFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDV------RRKEKENRKLHMELKS 1072
Query: 831 KKKR---ELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEH 882
++++ ++ +KEL E +Q + RIE++ + D +I +LR ++QA H
Sbjct: 1073 EREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALH 1127
Score = 54.3 bits (129), Expect = 6e-07
Identities = 61/329 (18%), Positives = 145/329 (44%), Gaps = 41/329 (12%)
Query: 189 LTQEM-SKQFLQSKNEGDKYKFFMKATQLEQ---MKEDYSYIMETKERTKEQIHQGEERL 244
L+ EM +K+ L+ K + + A +LE+ +++ + ER K + + +
Sbjct: 456 LSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALL---QHKN 512
Query: 245 TELKRQCVEKEERFQSIAG-LSTMKTNLESLKH-----EMAWAVVNEIEKQLNAIRDNIK 298
E +R+ + ++ +++ ++++K LE LK +++ VN++++QL+ ++
Sbjct: 513 AEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLR 572
Query: 299 IGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKR 358
D AARL + E ++ + E +D+QDK + E + L++ + +++R
Sbjct: 573 TESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERR 632
Query: 359 AYNEAEVLYNRSLNEYKALKKD--------------DEQLCKRIEELKKS---------- 394
+ N L++D QL +R +L+K
Sbjct: 633 DRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTY 692
Query: 395 ----TDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEHGKIKR 450
QSLE E E + + L ++ K +++ E + ++ +++ ++ + +++ K++
Sbjct: 693 QLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVEN 752
Query: 451 EELDVKHALSYNQRQLKELKDSKTDRLKR 479
L+ + S LK+ + + LK+
Sbjct: 753 LLLEAEKRCSLLDCDLKQSQQKINELLKQ 781
Score = 53.1 bits (126), Expect = 1e-06
Identities = 57/243 (23%), Positives = 111/243 (45%), Gaps = 32/243 (13%)
Query: 664 VDSEISDLENEVENKTAQILNLQQHLSALEKDI---KHNEELLKRCQLHYKELKMKIRKN 720
++ ++ +L ++E +T + Q L + + K +E+ LK+ H E+KM + K
Sbjct: 785 LNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQ 844
Query: 721 ISEIRELENIEEHQSVD--IATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAEN 778
+E+R +E Q D + L+D+ + + + + + + KE E L E +
Sbjct: 845 NAELR-----KERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQ 899
Query: 779 KYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDM 838
K ++ ++ LA L+ L ADSE + + Y + +KE + M
Sbjct: 900 KKQELQ---DERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKI-----------M 945
Query: 839 KEKELEEKMSQARQICPERIEVEKSASILD-KEINRLRQKIQAEHASHGDREEIMRQYQE 897
KE E++E M++ +Q EK A+I +E NR A A+ ++EE+ + ++
Sbjct: 946 KELEIKEMMARHKQEL-----TEKDATIASLEETNRTLTSDVANLAN--EKEELNNKLKD 998
Query: 898 ARE 900
+E
Sbjct: 999 VQE 1001
Score = 46.6 bits (109), Expect = 1e-04
Identities = 100/543 (18%), Positives = 220/543 (40%), Gaps = 69/543 (12%)
Query: 372 NEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLK--ERVKAFQNQENSVNQ 429
NE +A K++ EQ CK + + T + LE E R+ S L+ ER KA +N+
Sbjct: 458 NEMQA-KEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNA--- 513
Query: 430 EIEQFQQAIEKDKEEHGKIKREELDVKHALS--YNQRQLKELKDSKTDRLKRFGPNVPAL 487
++Q+ + + ++ ++ + +K L + Q ++ K ++L+R AL
Sbjct: 514 ---EYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNAL 570
Query: 488 LEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQA 547
L D + T + +ES + L C A ++ +
Sbjct: 571 LRTESDTAARLRKT-----------QAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKE 619
Query: 548 LMK-RFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPT---VLTALEIDNAVVANSLI 603
+ + L R SE N++ D +L +E++ +
Sbjct: 620 FINLQSALESERRDRTHGSEIINDLQG--RICGLEEDLKNGKILLAKVELEKRQLQERFT 677
Query: 604 DMRGIETVLLIKNNSVARAVMQS---QKPPKNCREAFTADGDQVFAGRYYSSENTRPKFL 660
D+ ++ + I + + QS ++ +A AD +++ Y S E + + +
Sbjct: 678 DLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKI----YESIEEAKSEAM 733
Query: 661 SRDVDSEISD---LENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKI 717
++++ ++ + L+ +VEN +L ++ S L+ D+K +++ + LK K
Sbjct: 734 -KEMEKKLLEERTLKQKVENL---LLEAEKRCSLLDCDLKQSQQKINEL------LKQKD 783
Query: 718 RKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAE 777
N ++R L E ++ +++ + ++ ++ +Q K+ HL +K+ E
Sbjct: 784 VLN-EDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLE 842
Query: 778 NKYDAIKFK----INQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKK 833
+ ++ + Q+ EL D L+ E + + K EEK K
Sbjct: 843 KQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEK--------TKLG 894
Query: 834 RELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMR 893
+EL K++EL+++ + + + ++ + +L + I E S ++E+IM+
Sbjct: 895 KELQQKKQELQDER--------DSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMK 946
Query: 894 QYQ 896
+ +
Sbjct: 947 ELE 949
Score = 46.6 bits (109), Expect = 1e-04
Identities = 61/327 (18%), Positives = 143/327 (43%), Gaps = 43/327 (13%)
Query: 182 VDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQ---------LEQMKEDYSYIMETKER 232
++ S +EM K+ L+ + K + + + L+Q ++ + +++ K+
Sbjct: 725 IEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDV 784
Query: 233 TKEQIHQGEERLT-ELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLN 291
E + ++ E +++C+ + + ++T+K + + LK E + +E ++N
Sbjct: 785 LNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENN----HLMEMKMN 840
Query: 292 AIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDI-QDKLEKISEETNARAPECMALK 350
+ N ++ ++R D +M+E Q +L EAEQ + + + ++ ++ EE + L
Sbjct: 841 LEKQNAELRKERQDA-DGQMKELQDQL-EAEQYFSTLYKTQVRELKEECEEKTK----LG 894
Query: 351 ADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKI 410
++ KK+ + L E K D EQL + I E + S LE E++ ++ +I
Sbjct: 895 KELQQKKQELQDERDSLAAQL-EITLTKADSEQLARSIAEEQYS---DLEKEKIMKELEI 950
Query: 411 SWLKERVKAFQNQENSVNQEIEQFQQAIEKD------------------KEEHGKIKREE 452
+ R K ++++ +E+ + + D +E+ ++K EE
Sbjct: 951 KEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEE 1010
Query: 453 LDVKHALSYNQRQLKELKDSKTDRLKR 479
+ + ++QL + KT + +
Sbjct: 1011 ISAAAIKAQFEKQLLTERTLKTQAVNK 1037
Score = 41.6 bits (96), Expect = 0.004
Identities = 68/333 (20%), Positives = 134/333 (40%), Gaps = 28/333 (8%)
Query: 589 TALEIDNAV-----VANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQ 643
TA E++ + V ++L + + +L KN R +N + DQ
Sbjct: 480 TAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQ 539
Query: 644 V--FAGRYYSSENTRPKF--LSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHN 699
+ R +S+ + K L R +D + L E + A++ Q S + ++ N
Sbjct: 540 LEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDT-AARLRKTQAESSKQIQQLESN 598
Query: 700 EELL--KRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEE 757
L K C L +LK++ E L++ E + D + + + ++ +EE
Sbjct: 599 NRDLQDKNCLLETAKLKLE-----KEFINLQSALESERRDRTHGSEIINDLQGRICGLEE 653
Query: 758 HMEQQKENMEHLKSLKIEAENKY-DAIKFKINQLSELADPLKDELNLADSEVDNQKRGKR 816
++ K + ++ K + + ++ D K K N ++ LK + E K K
Sbjct: 654 DLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKA 713
Query: 817 HYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQ 876
+K K + K + EK+L E+ + +++ +E EK S+LD ++ + +Q
Sbjct: 714 RLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQ 773
Query: 877 KIQAEHASHGDREEIMRQYQEARETYLDLDSKV 909
KI E+++Q E +L K+
Sbjct: 774 KI----------NELLKQKDVLNEDVRNLTLKI 796
Score = 40.4 bits (93), Expect = 0.009
Identities = 50/222 (22%), Positives = 103/222 (46%), Gaps = 39/222 (17%)
Query: 725 RELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIK 784
RE ++I+ ++ +E+QE + K+ +EEH+ + + E L+ K ++ N
Sbjct: 429 RETDSIQSRKN-------EESQEIQKKLYTLEEHLSNEMQAKEELEQ-KCKSVN------ 474
Query: 785 FKINQLSELADPLKDELNLADS------EVDNQKRGKRHYEEKQKEHLDTLNKKKRELDM 838
+L + A L++E+ L S +++ +K +H + + D KKR L+
Sbjct: 475 ---TRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLEN 531
Query: 839 KEKELEE------KMSQARQICPERI-----EVEKSASILDKEIN---RLRQKIQAEHAS 884
L++ K +Q QI E++ +++++ ++L E + RLR K QAE +
Sbjct: 532 DVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLR-KTQAESSK 590
Query: 885 HGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHR 926
+ E + + + L+ +K++ K+FI L + R
Sbjct: 591 QIQQLESNNRDLQDKNCLLE-TAKLKLEKEFINLQSALESER 631
Score = 34.7 bits (78), Expect = 0.51
Identities = 32/127 (25%), Positives = 58/127 (45%), Gaps = 17/127 (13%)
Query: 798 KDELNLADS----EVDN-QKRGKRHYEEKQK------EHLDTLNKKKRELDMKEKELEEK 846
++ L L+DS E D+ Q R +E QK EHL + K EL+ K K + +
Sbjct: 417 RENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTR 476
Query: 847 MSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARETYLDLD 906
+ + + E I + KS +++ R + +Q ++A E R+ + +L+
Sbjct: 477 LEKTAKELEEEITLRKSVESALRQLEREKALLQHKNA------EYQRKADHEADKKRNLE 530
Query: 907 SKVRTLK 913
+ V +LK
Sbjct: 531 NDVNSLK 537
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 77.0 bits (188), Expect = 9e-14
Identities = 127/644 (19%), Positives = 267/644 (41%), Gaps = 69/644 (10%)
Query: 226 IMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNE 285
I + K T+ ++ Q E +L E R+ +E + + K SLK E +
Sbjct: 116 IKKWKVSTEAELRQKESKLQE-NRKIIEAQRKAIQELQFGNEKV---SLKLEEGIQENKD 171
Query: 286 IEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPE 345
+ K+ NA R + ++ AR K ++ + E Q Y D+ + +EK+
Sbjct: 172 LIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKM---------- 221
Query: 346 CMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLE 405
+ A + +AE N L + LK+D E++ +E KK + +
Sbjct: 222 -------ITAFEELRVQAE---NSRLEMHFKLKEDYEKIQHLEQEYKKEIN--------D 263
Query: 406 RQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQ 465
++K++S L ++ +N+ + +E+ + + + +E K K + ++K ++
Sbjct: 264 KEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEE---KTKLQSENLKQSIEKQHHL 320
Query: 466 LKELKDSKTDRLKRFGPNVPALLEAIDDAYRQ-GHFTYKPVGPLGACIHLRDPELALAIE 524
KEL+D K L+R AL E + A + T + + + A A
Sbjct: 321 TKELEDIKVS-LQRSVSTQKALEEDLQIATKTICQLTEEKE------TQMEESNKARAAH 373
Query: 525 SCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDF 584
S + + C + E +L+ +R + I+ E + + ++
Sbjct: 374 SFVVTEFETTVC---SLEELLRTEQQRLE-KNEDQLKILTMELQKKSSELEE-------- 421
Query: 585 PTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQV 644
+T L + V L + G + LL +N + + + + A +V
Sbjct: 422 ---MTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEV 478
Query: 645 F-AGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELL 703
++ T ++ S++V DL+ E+EN+ + L H + L + K +
Sbjct: 479 HDLEIQLTAITTSEQYYSKEV----KDLKTELENEKLKNTELTSHCNKLSLENKELTQET 534
Query: 704 KRCQLHYKELKMKIRKNISE----IRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHM 759
L K + I N + ++++EN++E ++ LE +E K K V+ +
Sbjct: 535 SDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKL 594
Query: 760 EQQKENMEHLKSLKIEAENKY-DAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHY 818
++ +EN +L+ ++E +NKY + ++ + L + +LN+ + +V+ +
Sbjct: 595 DKSEENCNNLRK-QVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESA 653
Query: 819 EEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEK 862
++K E DT K+ + + E+ L E++ +A+ I E ++++K
Sbjct: 654 KQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQK 697
Score = 66.6 bits (161), Expect = 1e-10
Identities = 132/660 (20%), Positives = 264/660 (40%), Gaps = 84/660 (12%)
Query: 226 IMETKERTKEQIHQGEERLTELKRQCVEKEERFQS-IAGLSTMKTNLESLKHEMAWAVVN 284
+ ET R+ E+ + E E ++ ++ + I ++ E+ + EM + +
Sbjct: 186 LKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKE 245
Query: 285 EIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDI-------QDKLEKISE 337
+ EK + ++ K D+ ++++ +++ E E K KD+ +DK+ ++ E
Sbjct: 246 DYEKIQHLEQEYKKEINDK----EKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEE 301
Query: 338 ETNARAPECMALKADVVAKKRAYNEAE---VLYNRSLNEYKALKKDDEQLCKRIEELKKS 394
+T ++ LK + + E E V RS++ KAL++D + K I +L +
Sbjct: 302 KTKLQSEN---LKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEE 358
Query: 395 TDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEHGKIKREELD 454
+ +E R + E F+ S+ + + QQ +EK+ E+ KI EL
Sbjct: 359 KETQMEESNKARAAHSFVVTE----FETTVCSLEELLRTEQQRLEKN-EDQLKILTMELQ 413
Query: 455 VKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHL 514
K + +L K+ + + LK+ LL Y F
Sbjct: 414 KKSSELEEMTKLTNNKEVELEELKKVLGEKETLL------YENKQFE------------- 454
Query: 515 RDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDV 574
+ E E L GLLQA H E L A+ T+ E ++ ++
Sbjct: 455 KIAEELKGTEQELIGLLQAREKEVHDLEIQLTAI--------TTSEQYYSKEVKDLKTEL 506
Query: 575 RHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKN-----NSVARAVMQSQKP 629
+ + + + L ++N + DM L +KN N+ + + K
Sbjct: 507 ENEKLKNTELTSHCNKLSLENKELTQETSDM-----TLELKNQQEDINNNKKQEERMLKQ 561
Query: 630 PKNCREAFTADGDQV-FAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQILNLQQH 688
+N +E T +++ + + K + ++L +VENK I LQQ
Sbjct: 562 IENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQE 621
Query: 689 LSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQEN 748
AL+K + L ++ +L++++ + E+ + + + D E+ E
Sbjct: 622 NKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEE 681
Query: 749 KSKMKMV-EEHMEQQKE-------NMEHLKSLKIEAENKYDAI-----------KFKINQ 789
K K++ +E ++ QKE + + +L + +++YD I K K +
Sbjct: 682 VEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQE 741
Query: 790 LSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQ 849
S L L+ EL+ +E+ + K+ E ++E + L ++ +E KE ++K +Q
Sbjct: 742 QSSLRASLEIELSNLKAELLSVKK----QLEIEREEKEKLKREAKENTATLKEKKDKKTQ 797
Score = 62.0 bits (149), Expect = 3e-09
Identities = 65/279 (23%), Positives = 133/279 (47%), Gaps = 36/279 (12%)
Query: 218 QMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHE 277
++KEDY I ++ K++I+ E++++ L Q EKE + + + L LE + +
Sbjct: 242 KLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFL------LEESRDK 295
Query: 278 MAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISE 337
VN++E++ +N+K ++ L +++E+ +V L + K +++ L+ I+
Sbjct: 296 -----VNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQ-IAT 349
Query: 338 ETNARAPECMALKADVVAKKRAYNEAEV---------LYNRSLNEYKALKKDDEQLCKRI 388
+T + E + + K RA + V L E + L+K+++QL
Sbjct: 350 KTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILT 409
Query: 389 EELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEK----DKEE 444
EL+K + + E +L K++ E +K ++ ++ E +QF++ E+ ++E
Sbjct: 410 MELQKKSSELEEMTKLTNNKEVE--LEELKKVLGEKETLLYENKQFEKIAEELKGTEQEL 467
Query: 445 HGKIKREELDVKHAL--------SYNQRQLKELKDSKTD 475
G ++ E +V H L + Q KE+KD KT+
Sbjct: 468 IGLLQAREKEV-HDLEIQLTAITTSEQYYSKEVKDLKTE 505
Score = 56.6 bits (135), Expect = 1e-07
Identities = 78/299 (26%), Positives = 127/299 (42%), Gaps = 45/299 (15%)
Query: 189 LTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLT--- 245
LTQE S L+ KN+ + K Q E+M + + ET+ + + ++ E L
Sbjct: 530 LTQETSDMTLELKNQQEDINNNKK--QEERMLKQIENLQETETQLRNELEYVREELKQKR 587
Query: 246 -ELKRQCVEKEERFQSIAGLSTMKTN-LESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDR 303
E+K + + EE ++ K +E L+ E ++K+ A + + E +
Sbjct: 588 DEVKCKLDKSEENCNNLRKQVENKNKYIEELQQEN-----KALKKKGTAESKQLNVYEIK 642
Query: 304 AARLDRKMEEQQVRLNEAEQKY-KDIQDKLEKISEETNARAPECMALKADVVAKKRAYNE 362
+L+ ++E + + E Y K+I+DK KISEE E + AD K + E
Sbjct: 643 VNKLELELESAKQKFGEITDTYQKEIEDK--KISEENLLEEVEKAKVIADEAVKLQ--KE 698
Query: 363 AEVLYNRSLNEYKAL-KKDDEQLCKRIEE------LKKSTDQSLEPERLERQKKISWLKE 415
+ + E AL +K Q K IEE L KS +Q R + ++S LK
Sbjct: 699 IDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKA 758
Query: 416 RVKAFQNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKT 474
+ + + Q +E ++EE K+KRE + N LKE KD KT
Sbjct: 759 ELLSVKKQ--------------LEIEREEKEKLKREAKE-------NTATLKEKKDKKT 796
Score = 55.1 bits (131), Expect = 4e-07
Identities = 124/669 (18%), Positives = 246/669 (36%), Gaps = 113/669 (16%)
Query: 254 KEERFQSIAGLSTMKTNLESLKHEMA-WAVVNEIE--KQLNAIRDNIKIGEDRAARLDRK 310
K+ ++ GLS + + L ++ W V E E ++ + +++N KI E + +
Sbjct: 92 KDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQEL 151
Query: 311 M---EEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLY 367
E+ ++L E Q+ KD+ +E NA C LK + E
Sbjct: 152 QFGNEKVSLKLEEGIQENKDL-------IKENNATRHLCNLLKETCARSAEKTKKYEYER 204
Query: 368 NRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSV 427
+ Y L + E++ EEL+ + S RLE K LKE + Q+ E
Sbjct: 205 EETRQVYMDLNNNIEKMITAFEELRVQAENS----RLEMHFK---LKEDYEKIQHLEQEY 257
Query: 428 NQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPAL 487
+EI DKE+ + ++ K + L L + D++ +
Sbjct: 258 KKEIN--------DKEKQVSLLLIQITEKEN---KMKDLTFLLEESRDKVNQLEEKTKLQ 306
Query: 488 LEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQA 547
E + + + H K + + + R A+E L+ + C E ++
Sbjct: 307 SENLKQSIEKQHHLTKELEDIKVSLQ-RSVSTQKALEEDLQIATKTICQLTEEKETQMEE 365
Query: 548 LMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRG 607
K + +V+EF + SL ++
Sbjct: 366 SNK-----ARAAHSFVVTEFETTVC----------------------------SLEELLR 392
Query: 608 IETVLLIKNNSVARAV-MQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDS 666
E L KN + + M+ QK SSE L+ + +
Sbjct: 393 TEQQRLEKNEDQLKILTMELQKK---------------------SSELEEMTKLTNNKEV 431
Query: 667 EISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELK-MKIRKNISEIR 725
E+ +L+ + K + +Q E+ +EL+ Q KE+ ++I ++
Sbjct: 432 ELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEI-----QLT 486
Query: 726 ELENIEEHQSVDIATLEDEAQENKSKMKMVEEHME----QQKENMEHLKSLKIEAENKYD 781
+ E++ S ++ L+ E + K K + H + KE + + +E +N+ +
Sbjct: 487 AITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQE 546
Query: 782 AIKF----------KINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNK 831
I +I L E L++EL E+ ++ + +K +E+ + L K
Sbjct: 547 DINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRK 606
Query: 832 KKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEI 891
+++ K K +EE + + + + K ++ + ++N+L ++++ G EI
Sbjct: 607 ---QVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFG---EI 660
Query: 892 MRQYQEARE 900
YQ+ E
Sbjct: 661 TDTYQKEIE 669
Score = 52.0 bits (123), Expect = 3e-06
Identities = 63/321 (19%), Positives = 136/321 (42%), Gaps = 21/321 (6%)
Query: 189 LTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELK 248
LT+E Q +S + F + T+ E ++ T++ +++ + E++L L
Sbjct: 355 LTEEKETQMEESNKARAAHSFVV--TEFETTVCSLEELLRTEQ---QRLEKNEDQLKILT 409
Query: 249 RQCVEKEERFQSIAGLSTMK-TNLESLKHEMAWAVVNEIE-KQLNAIRDNIKIGEDRAAR 306
+ +K + + L+ K LE LK + E KQ I + +K E
Sbjct: 410 MELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIG 469
Query: 307 LDRKMEE-------QQVRLNEAEQKY----KDIQDKLEKISEETNARAPECMALKADVVA 355
L + E+ Q + +EQ Y KD++ +LE + C L +
Sbjct: 470 LLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKE 529
Query: 356 KKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQ---SLEPERLERQKKISW 412
+ ++ + + KK +E++ K+IE L+++ Q LE R E ++K
Sbjct: 530 LTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDE 589
Query: 413 LKERVKAFQNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDS 472
+K ++ + N++ +++E + IE+ ++E+ +K++ L+ + ++ +L+
Sbjct: 590 VKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELE 649
Query: 473 KTDRLKRFGPNVPALLEAIDD 493
++FG + I+D
Sbjct: 650 LESAKQKFGEITDTYQKEIED 670
Score = 43.5 bits (101), Expect = 0.001
Identities = 58/299 (19%), Positives = 120/299 (40%), Gaps = 40/299 (13%)
Query: 651 SSENTRPKFLSRDVDSEI-SDLENEVENKTAQI--LNLQQHLSALEKDIKHNE--ELLKR 705
S+E T+ R+ ++ DL N +E L +Q S LE K E E ++
Sbjct: 193 SAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQH 252
Query: 706 CQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKEN 765
+ YK+ K +S + +E++ D+ L +E++ K+ +EE + Q EN
Sbjct: 253 LEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFL---LEESRDKVNQLEEKTKLQSEN 309
Query: 766 MEHLKSLKIEAENKYDAIKFKINQLSELADPLKDELNLA-------------DSEVDNQK 812
++ + + + IK + + L+++L +A E N+
Sbjct: 310 LKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKA 369
Query: 813 RGKRHY------------EEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICP----E 856
R + EE + L K + +L + EL++K S+ ++ +
Sbjct: 370 RAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNK 429
Query: 857 RIEVEKSASILDKEINRLRQKIQAEHASH---GDREEIMRQYQEARETYLDLDSKVRTL 912
+E+E+ +L ++ L + Q E + G +E++ Q + DL+ ++ +
Sbjct: 430 EVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAI 488
Score = 38.9 bits (89), Expect = 0.027
Identities = 53/269 (19%), Positives = 112/269 (41%), Gaps = 37/269 (13%)
Query: 680 AQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVD-- 737
A++ + L K I+ + ++ Q +++ +K+ + I E ++L I+E+ +
Sbjct: 125 AELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDL--IKENNATRHL 182
Query: 738 IATLEDEAQENKSKMKMVEEHMEQQKE-------NMEHL----KSLKIEAENKYDAIKFK 786
L++ + K K E E+ ++ N+E + + L+++AEN + FK
Sbjct: 183 CNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFK 242
Query: 787 INQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEK 846
+ + D +K +H E++ K+ ++ K+ L ++ E E K
Sbjct: 243 LKE-------------------DYEKI--QHLEQEYKKEINDKEKQVSLLLIQITEKENK 281
Query: 847 MSQARQICPE-RIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARETYLDL 905
M + E R +V + + L+Q I+ +H + E+I Q + T L
Sbjct: 282 MKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKAL 341
Query: 906 DSKVRTLKKFIKLLGEIMEHRFKTYQQFR 934
+ ++ K I L E E + + + R
Sbjct: 342 EEDLQIATKTICQLTEEKETQMEESNKAR 370
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 76.6 bits (187), Expect = 1e-13
Identities = 154/779 (19%), Positives = 318/779 (40%), Gaps = 121/779 (15%)
Query: 189 LTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELK 248
L ++Q L+SK E + +K T E+ K + I E +++ + + + E+L + K
Sbjct: 1152 LDSTAAQQELRSKREQEVN--ILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTK 1209
Query: 249 RQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLD 308
R A L K LE+ + E+A NE++ L D+ E + +++
Sbjct: 1210 RVK----------ANLEKAKQTLENERGELA----NEVKVLLQGKGDS----EHKRKKVE 1251
Query: 309 RKMEEQQVRLNEAEQKYKDIQDKLEKISEE-------TNARAPECMALKADVVAKKRAYN 361
+++E QV+ NE E+ ++ DK+ K+ E + + L D A +
Sbjct: 1252 AQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQ 1311
Query: 362 EAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLER---QKKISWLKERVK 418
+ + L L E K K++E+ K S + LE E + +K+I+ L +V
Sbjct: 1312 DTQEL----LQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVA 1367
Query: 419 AFQNQ-ENSVN--QEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDS--- 472
+ + E+SV + E+ ++ ++KD E + E++ L + +L++ D
Sbjct: 1368 DMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLV 1427
Query: 473 KTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQ 532
D ++ N+ + D + K + A RD A A E K L
Sbjct: 1428 DLDHQRQSACNLEKKQKKFDQLLAE----EKTISAKYA--EERDRAEAEAREKETKALSL 1481
Query: 533 AYCCHNHADERV-LQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTAL 591
A +++ L+ L K +FR E+ D+ + D + L
Sbjct: 1482 ARALEEAMEQKAELERLNK---------------QFRTEMEDL---MSSKDDVGKSVHEL 1523
Query: 592 EIDNAVVANSLIDMR----GIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAG 647
E + + +M+ +E L ++ R + Q A A ++ G
Sbjct: 1524 EKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQ--------AMKAQFERDLQG 1575
Query: 648 RYYSSENTRPKFLS--RDVDSEISDLENEVENKTAQILNLQQHLSALEKDI----KHNEE 701
R SE + + + R++++E+ D + A L+ L LE I K+ +E
Sbjct: 1576 RDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDE 1635
Query: 702 LLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQ 761
+K QL + +MK +REL++ + +A +A+EN+ K+K +E M Q
Sbjct: 1636 AIK--QLRKLQAQMK-----DCMRELDDTRASREEILA----QAKENEKKLKSMEAEMIQ 1684
Query: 762 QKENMEHLKSLKIEAENKYDAIKFKI------------------NQLSELADPLKDELNL 803
+E + + K +A+ + D + +I ++++L + L++E
Sbjct: 1685 LQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGN 1744
Query: 804 ADSEVDNQKRGKRHYEE------KQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPER 857
+ D K+ ++ ++ H +++L+ + KEL+ K+ + +
Sbjct: 1745 TELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSK 1804
Query: 858 IEVEKSASILDKEINRLRQKIQAE-HASHGDREEIMRQYQEARETYLDLDSKVRTLKKF 915
+ S + L+ +I +L +++ E +++ R ++ ++ L +D + R +++
Sbjct: 1805 YKA--SITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQY 1861
Score = 75.9 bits (185), Expect = 2e-13
Identities = 124/685 (18%), Positives = 281/685 (41%), Gaps = 63/685 (9%)
Query: 236 QIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRD 295
+ ++GE TEL + + + ++ GL + + S ++ K +A+
Sbjct: 1260 KFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSS-----------KLTKDFSALES 1308
Query: 296 NIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVA 355
++ ++ +R+ +L + E + +++LE+ E + + L A V
Sbjct: 1309 QLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVAD 1368
Query: 356 KKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKE 415
K+ ++ + + L+KD E L +R EE + D+ LE + Q+++ L
Sbjct: 1369 MKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDK-LEKTKTRLQQELDDLLV 1427
Query: 416 RVKAFQNQENSVNQEIEQFQQAIEKDK-------EEHGKIKREELDVKHALSYNQRQLKE 468
+ + ++ ++ ++F Q + ++K EE + + E + + R L+E
Sbjct: 1428 DLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEE 1487
Query: 469 LKDSKTD--RL-KRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIES 525
+ K + RL K+F + L+ + DD + H K L + E+ +E
Sbjct: 1488 AMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVE----EMKTQLEE 1543
Query: 526 CLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFP 585
L+ LQA E LQA+ +F R + + + VR A D
Sbjct: 1544 -LEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELED-- 1600
Query: 586 TVLTALEIDNAVVANSLI--DMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQ 643
+ AV A + D++ +E + N + A+ Q +K ++ D
Sbjct: 1601 ---ERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDT 1657
Query: 644 VFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNE--- 700
+ ++ + + +++E+ L+ E+ QQ L +I ++
Sbjct: 1658 RASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKG 1717
Query: 701 ----ELLKRCQLHYKELKMKIRKN------ISEIRELENIEEHQ-SVDIATLEDEAQENK 749
E +R + +L+ ++ + I++ + N++ Q + D+ AQ+N+
Sbjct: 1718 ALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNE 1777
Query: 750 SKMKMVEEHMEQQKENMEHLK-SLKIEAENKYDAIKFKINQLSELADPLKDELNLADSEV 808
+ + +E ++ K ++ ++ ++K + + A++ KI QL E D E A +V
Sbjct: 1778 NARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQV 1837
Query: 809 --------------DNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQIC 854
D+++R Y+++ + L + KR+L+ E+E + + R++
Sbjct: 1838 RRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQ 1897
Query: 855 PERIEVEKSASILDKEINRLRQKIQ 879
E + ++A +++E++ L+ K++
Sbjct: 1898 RELEDATETADAMNREVSSLKNKLR 1922
Score = 73.2 bits (178), Expect = 1e-12
Identities = 151/851 (17%), Positives = 333/851 (39%), Gaps = 128/851 (15%)
Query: 191 QEMSKQFLQSKNEGD------KYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERL 244
+E SK + KN+ + + + + Q +++++ + +QI + + ++
Sbjct: 1012 EEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI 1071
Query: 245 TELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIK------ 298
ELK Q +KEE Q+ + + E+ + MA + E+E Q++ ++++++
Sbjct: 1072 AELKMQLAKKEEELQA----ALARVEEEAAQKNMALKKIRELESQISELQEDLESERASR 1127
Query: 299 ---------IGEDRAA-------RLD--------RKMEEQQVRL------NEAEQKYKDI 328
+GE+ A LD R EQ+V + EA+ I
Sbjct: 1128 NKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQI 1187
Query: 329 QDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKAL---KKDDEQLC 385
Q+ +K S+ A + K ++A E NE K L K D E
Sbjct: 1188 QEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKR 1247
Query: 386 KRIE------ELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIE 439
K++E ++K + + + E ++ K+ + V +Q +S + ++ + A+E
Sbjct: 1248 KKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALE 1307
Query: 440 KDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGH 499
++ ++ +EE K +LS +Q+++ K+S ++L+ L + I + Q
Sbjct: 1308 SQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVA 1367
Query: 500 FTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSR 559
K + C+ + E+ ++ L+GL Q + +E+V
Sbjct: 1368 DMKKKMEDSVGCLETAE-EVKRKLQKDLEGLSQRH------EEKV--------------- 1405
Query: 560 PPIIVSEFRNEIYD--VRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNN 617
YD + + + +L L+ N + + +L +
Sbjct: 1406 ----------AAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKT 1455
Query: 618 SVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVEN 677
A+ + + RE T A + + L++ +E+ DL + ++
Sbjct: 1456 ISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDD 1515
Query: 678 KTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVD 737
+ L++ ALE+ + +E+K ++ + E++ E+ + V+
Sbjct: 1516 VGKSVHELEKSKRALEQQV--------------EEMKTQLEELEDELQATEDAKLRLEVN 1561
Query: 738 IATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSELADPL 797
+ + +AQ + E+ E++K+ + ++ ++ E E++ + +L L
Sbjct: 1562 LQAM--KAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDL 1619
Query: 798 KDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPER 857
KD DS N+ + + Q + D + RELD EE ++QA+
Sbjct: 1620 KDLEAHIDSANKNRDEAIKQLRKLQAQMKDCM----RELDDTRASREEILAQAK------ 1669
Query: 858 IEVEKSASILDKEINRLRQKI----QAEHASHGDREEIMRQY-QEARETYLDLDSKVRTL 912
E EK ++ E+ +L++++ +A+ + +R+E+ + + + L L+ K R
Sbjct: 1670 -ENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLE 1728
Query: 913 KKFIKLLGEIMEHRFKTYQQFRRCL-------TLRCKLYFDNLLSQRAYCGKMNFDHKNE 965
+ +L E+ E + T R + L + +Q+ + + +N+
Sbjct: 1729 ARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNK 1788
Query: 966 TLSISVQPGEG 976
L + +Q EG
Sbjct: 1789 ELKVKLQEMEG 1799
Score = 71.6 bits (174), Expect = 4e-12
Identities = 146/773 (18%), Positives = 305/773 (39%), Gaps = 127/773 (16%)
Query: 207 YKFFMKATQLEQMKEDYSYIMETKE---RTKEQIHQGEERLTELK----RQCVEKEERFQ 259
++ F K L Q+ +M +E + +E+ E RLTE++ + EK + +
Sbjct: 828 WRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQE 887
Query: 260 SIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLN 319
+ + + E L+ + A E+E+ + + ++ E+R L + ++ Q +
Sbjct: 888 QLQAETELCAEAEELRARLT-AKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ 946
Query: 320 EAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKK 379
E E++ ++ + +K+ E K AK + E +++
Sbjct: 947 ELEEQLEEEESARQKLQLE-----------KVTTEAKLKKLEEEQIIL------------ 983
Query: 380 DDEQLCKRIEELKKSTDQSLE-----PERLERQKKISWLKERVKAFQNQENSVNQEIEQF 434
++Q CK +E K D+ E E E+ K ++ LK + +A + E+
Sbjct: 984 -EDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQ 1042
Query: 435 QQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDA 494
+Q +EK + K++ + D+ ++ Q Q+ ELK +L + + A L +++
Sbjct: 1043 RQELEKTRR---KLEGDSTDLSDQIAELQAQIAELK----MQLAKKEEELQAALARVEEE 1095
Query: 495 YRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADER------VLQAL 548
Q + K + EL I + L N A+++ L+AL
Sbjct: 1096 AAQKNMALKKI-----------RELESQISELQEDLESERASRNKAEKQKRDLGEELEAL 1144
Query: 549 MKRF--YLPGTSRPPIIVSEFRNEIYDVRH----------------RAAYHPDFPTVLTA 590
L T+ + S+ E+ ++ R + +
Sbjct: 1145 KTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQ 1204
Query: 591 LEIDNAVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYY 650
LE V AN + +E N V + ++Q + ++ R+ A ++ ++
Sbjct: 1205 LEQTKRVKANLEKAKQTLENERGELANEV-KVLLQGKGDSEHKRKKVEAQLQELQV-KFN 1262
Query: 651 SSENTRPKFLSR--DVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELL----- 703
E R + + + E+ ++ + ++ L + SALE ++ +ELL
Sbjct: 1263 EGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENR 1322
Query: 704 KRCQLHYKELKMKIRKNI--SEIRELENIEEHQSVDIATLEDEAQENKSKM--------- 752
++ L K +++ KN ++ E E + + IATL + + K KM
Sbjct: 1323 QKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLET 1382
Query: 753 -KMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQ 811
+ V+ +++ E + K+ A +K + K ++ Q EL D L D +D+Q
Sbjct: 1383 AEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQ--ELDDLLVD--------LDHQ 1432
Query: 812 KRGKRHYEEKQKEHLDTLNKKK-------RELDMKEKELEEKMSQARQICPERIEVEKSA 864
++ + E+KQK+ L ++K E D E E EK ++A + E +
Sbjct: 1433 RQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQK 1492
Query: 865 SILDKEINRLRQKIQAEHASHGDREEIMRQYQEARETYLDLDSKVRTLKKFIK 917
+ E+ RL ++ + E E++M + ++ +L+ R L++ ++
Sbjct: 1493 A----ELERLNKQFRTE------MEDLMSSKDDVGKSVHELEKSKRALEQQVE 1535
Score = 52.0 bits (123), Expect = 3e-06
Identities = 57/265 (21%), Positives = 113/265 (42%), Gaps = 13/265 (4%)
Query: 665 DSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEI 724
++ ++++E A+ L LQ+ L A + EEL R +EL+ + +
Sbjct: 865 ENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARV 924
Query: 725 RELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIK 784
E E +H L+ E ++ + ++ +EE +E+++ + L+ K+ E K ++
Sbjct: 925 EEEEERCQH-------LQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLE 977
Query: 785 FKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELE 844
+ L + L E L + + EEK K NK + + E+ L
Sbjct: 978 EEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLR 1037
Query: 845 EKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREE-----IMRQYQEAR 899
+ Q +++ R ++E ++ L +I L+ +I +EE + R +EA
Sbjct: 1038 REEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAA 1097
Query: 900 ETYLDLDSKVRTLKKFIKLLGEIME 924
+ + L K+R L+ I L E +E
Sbjct: 1098 QKNMAL-KKIRELESQISELQEDLE 1121
Score = 50.4 bits (119), Expect = 9e-06
Identities = 59/291 (20%), Positives = 132/291 (45%), Gaps = 41/291 (14%)
Query: 660 LSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRK 719
+ D+++ + + E ++ A+ +QQ++ LE+ ++ E ++ QL + K++K
Sbjct: 916 ICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKK 975
Query: 720 NISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENM----EHLKSLKIE 775
+EE Q + LED+ + + K++E+ + + N+ E KSL +
Sbjct: 976 ----------LEEEQII----LEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLA-K 1020
Query: 776 AENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLN----K 831
+NK++A+ + + + + EL +++ + + + L K
Sbjct: 1021 LKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAK 1080
Query: 832 KKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEI 891
K+ EL +EE+ +Q K L+ +I+ L++ +++E AS E+
Sbjct: 1081 KEEELQAALARVEEEAAQKNMAL-------KKIRELESQISELQEDLESERASRNKAEKQ 1133
Query: 892 MR---QYQEARETYLD--LDS-----KVRTLK-KFIKLLGEIMEHRFKTYQ 931
R + EA +T L+ LDS ++R+ + + + +L + +E KT++
Sbjct: 1134 KRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHE 1184
Score = 50.1 bits (118), Expect = 1e-05
Identities = 55/278 (19%), Positives = 119/278 (42%), Gaps = 9/278 (3%)
Query: 200 SKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQ 259
+KN + K K QMK+ + +T+ +E + Q +E +LK E + +
Sbjct: 1630 NKNRDEAIKQLRKLQA--QMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQE 1687
Query: 260 SIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLN 319
+A K + + E+A + N K A+ + ++ E R A+L+ ++EE+Q
Sbjct: 1688 ELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRL-EARIAQLEEELEEEQGNTE 1746
Query: 320 EAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKA-LK 378
+ K ++++I+ + N + +R E +V K+ K
Sbjct: 1747 LINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYK 1806
Query: 379 KDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAI 438
L +I +L++ D + ER K++ ++++K Q + + EQ++
Sbjct: 1807 ASITALEAKIAQLEEQLDNETK-ERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQA 1865
Query: 439 EKDKEEHGKIKRE----ELDVKHALSYNQRQLKELKDS 472
+K ++KR+ E + + A + ++ +EL+D+
Sbjct: 1866 DKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDA 1903
Score = 31.6 bits (70), Expect = 4.3
Identities = 40/191 (20%), Positives = 87/191 (45%), Gaps = 29/191 (15%)
Query: 186 VSVLTQEMSKQFLQSKNEGDKYKFFMKAT-QLEQMKEDYSYIMETKERTKEQIHQGEERL 244
++ L +E+ ++ ++ D+ K KA Q++Q+ D + ++ + Q E +
Sbjct: 1731 IAQLEEELEEEQGNTELINDRLK---KANLQIDQINTDLNLERSHAQKNENARQQLERQN 1787
Query: 245 TELKRQCVEKEERFQSI--AGLSTMKTNLESLKHEM---------AWAVVNEIEKQLNAI 293
ELK + E E +S A ++ ++ + L+ ++ A V EK+L +
Sbjct: 1788 KELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDV 1847
Query: 294 -------RDNIKIGEDRAARLDRKMEEQQVRLNEAEQK-------YKDIQDKLEKISEET 339
R N + +D+A + ++++ + +L EAE++ + +Q +LE +E
Sbjct: 1848 LLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETA 1907
Query: 340 NARAPECMALK 350
+A E +LK
Sbjct: 1908 DAMNREVSSLK 1918
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 76.6 bits (187), Expect = 1e-13
Identities = 161/795 (20%), Positives = 331/795 (41%), Gaps = 95/795 (11%)
Query: 180 IQVDNPVSVLTQEMSKQ-FLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETK--ERTKEQ 236
+Q + Q++ +Q L + K F M+ + L++ + Y + K KE+
Sbjct: 264 LQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEE 323
Query: 237 IHQGEERLTELKRQCVEKEERFQSIAG-LSTMKTNLESLKHEMAWA--VVNEIEKQLNAI 293
I + E + EL + +E+E++ + L+T L L+ ++ + ++ +L
Sbjct: 324 IQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNS 383
Query: 294 RDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADV 353
+ + + +L +EE Q R ++ Q DI ++E +ET + + A
Sbjct: 384 KQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRME---QETQRKLEQLRA----- 435
Query: 354 VAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWL 413
E + +Y + + + K ++ Q ++EE+K +E L I+
Sbjct: 436 --------ELDEMYGQQIVQMK--QELIRQHMAQMEEMKTRHKGEME-NALRSYSNITVN 484
Query: 414 KERVKAFQNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSK 473
++++K N +N +++ EK KEE G I L+ K AL QRQL++L +
Sbjct: 485 EDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLI----LEEKCAL---QRQLEDLVEEL 537
Query: 474 TDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQA 533
+ ++ + E + + H + V L A I + E +E + +
Sbjct: 538 SFSREQIQRARQTIAEQ-ESKLNEAHKSLSTVEDLKAEI-VSASESRKELELKHEAEVTN 595
Query: 534 YCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEI 593
Y E+ A++ R + R ++ ++ + + LEI
Sbjct: 596 YKIKLEMLEKEKNAVLDRM----AESQEAELERLRTQLL-----FSHEEELSKLKEDLEI 646
Query: 594 DNAVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSE 653
++ + L D GI I +Q++ K F D + +
Sbjct: 647 EHRINIEKLKDNLGIHYKQQIDG-------LQNEMSQKIETMQFEKDN-------LITKQ 692
Query: 654 NTRPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKEL 713
N +S+ D + S + ++ E T QI LQ+ + L ++ K L + Q EL
Sbjct: 693 NQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQ----EL 748
Query: 714 KMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHME-----QQKENMEH 768
++K +++E EN + + A LE E K + K +E+ ++ Q+E +
Sbjct: 749 QLKTELLEKQMKEKENDLQEK---FAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805
Query: 769 LKSLKIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQ--------KRGKRHYEE 820
L S+K +++K + +I L E + LK + + E++ Q K + +Y+E
Sbjct: 806 LDSIK--SKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQE 863
Query: 821 KQKEHL----------DTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKE 870
Q+E+ D+ NK++ E K K L E++ ++I P ++++ +S+ D++
Sbjct: 864 LQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL-HLQRINPTTVKMK--SSVFDED 920
Query: 871 INRLRQKIQAEHASHGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLL-GEI--MEHRF 927
+ + ++ D E+M + + + L+L ++ L + +K GEI +
Sbjct: 921 KTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEV 980
Query: 928 KTYQQFRRCLTLRCK 942
K+ +Q + ++LRC+
Sbjct: 981 KSLKQEKEQVSLRCR 995
Score = 68.6 bits (166), Expect = 3e-11
Identities = 145/760 (19%), Positives = 298/760 (39%), Gaps = 88/760 (11%)
Query: 169 EELIAILDHFNIQVDNPVSVLTQEMSKQFLQSK--------NEGDKYKFFMKATQLEQMK 220
E++ LD I ++ V QE+ K Q K +E + A L++
Sbjct: 2063 EKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKT 2122
Query: 221 EDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAW 280
+ S ++ +KE+ + I + E + +L+ + E E+ + T + +E KH A
Sbjct: 2123 DKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL--LVSADTFQ-KVEDRKHFGAV 2179
Query: 281 AVVNEI--EKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEE 338
E+ E QL A RD I E L+ ++E+ + L ++ + + +LE +E
Sbjct: 2180 EAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKE 2239
Query: 339 TNARAPEC----MALKADVVAKKRAYNEAE--------VLYNR--SLNEYKALKKD--DE 382
+ R E K D+ A E++ VL+ + + + K ++ D +E
Sbjct: 2240 STTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNE 2299
Query: 383 QLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVN----QEIEQFQQAI 438
Q+ K ++LK +TD + E+ E I L+ +++ + + V +EIEQ + I
Sbjct: 2300 QVTKLQQQLKITTDNKVIEEKNEL---IRDLETQIECLMSDQECVKRNREEEIEQLNEVI 2356
Query: 439 EKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQG 498
E K+++E ++ S N L E DS +L AL + ++ A +
Sbjct: 2357 E-------KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEM 2409
Query: 499 HFTYKPVGPLGACIH---------LRDPELALAIESCLKGLLQAYCCHNHADERVLQALM 549
F + ++ R+ E I+S + + H D+ L+ ++
Sbjct: 2410 TFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVL 2469
Query: 550 KRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMR--- 606
L S N + + + ++A +++ + DM+
Sbjct: 2470 TEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQG 2529
Query: 607 GIETVLL----------IKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTR 656
ET +L ++ A V Q Q F D + + ++
Sbjct: 2530 QFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNL 2589
Query: 657 PKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMK 716
+ ++ S+IS L + +Q++ + L ++ ++ E+ + + EL+
Sbjct: 2590 NQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKL 2649
Query: 717 IRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEA 776
+ N + RE E Q V++ E H ++ L++L+ E+
Sbjct: 2650 LEGNEKKQREKEKKRSPQDVEVLKTTTEL-----------FHSNEESGFFNELEALRAES 2698
Query: 777 ENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKREL 836
A K ++ E A+ L++EL + ++ + + ++ + D L + K +L
Sbjct: 2699 V----ATKAELASYKEKAEKLQEELLVKETNMTS-------LQKDLSQVRDHLAEAKEKL 2747
Query: 837 DMKEKELEEKMSQARQICP-ERIEVEKSASILDKEINRLR 875
+ EKE E ++ ++++ C E + ++ S SI + L+
Sbjct: 2748 SILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLK 2787
Score = 66.2 bits (160), Expect = 2e-10
Identities = 166/791 (20%), Positives = 314/791 (39%), Gaps = 114/791 (14%)
Query: 175 LDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTK 234
+D N ++ +S Q ++ L++ +E K TQ E M+E + E E K
Sbjct: 1835 IDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK 1894
Query: 235 EQIHQGEERLTELKRQ----CVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQL 290
Q + ERL E R VE + I G + KT E E +++ +E++L
Sbjct: 1895 CQ-EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKT-DIIDRLEQEL 1952
Query: 291 NAIRDNIK--------IGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNAR 342
+ ++ I E+R L R+ E + EQ+ +KL K E +
Sbjct: 1953 LCASNRLQELEAEQQQIQEEREL-LSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQ 2011
Query: 343 AP--------ECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKS 394
A + AL+ DV + + E E N L + L++ ++ L K++E+++K
Sbjct: 2012 AEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMD---LRQQNQALEKQLEKMRKF 2068
Query: 395 TDQSL---EPERLERQKKISWLKERVKA---FQNQENSVNQEIEQFQQAIEK--DKEEHG 446
D+ E ER Q++I L++++K FQ +E+EQ +++ DK
Sbjct: 2069 LDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSEL 2128
Query: 447 KIKREELDVKHALSYNQRQLKELKDSKTDRLK-RFGPNVPALLEAIDDAYR---QGHFTY 502
+ +E+L QR ++E ++ + ++L+ R ALL + D + + HF
Sbjct: 2129 LLSKEQL---------QRDIQE-RNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHF-- 2176
Query: 503 KPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPI 562
G + A PEL+L ++ LQA E+ + L ++
Sbjct: 2177 ---GAVEA-----KPELSLEVQ------LQAERDAIDRKEKEITNLEEQ----------- 2211
Query: 563 IVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVARA 622
+ +FR E+ + + + LEI L ++ + + A
Sbjct: 2212 -LEQFREELENKNE------EVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLA 2264
Query: 623 VMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQI 682
+ +S + Q+ + + + +I+ +E K I
Sbjct: 2265 IKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELI 2324
Query: 683 LNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLE 742
+L+ + L D +E +KR + E ++ + + + EL NI + S++ +L
Sbjct: 2325 RDLETQIECLMSD----QECVKRNREEEIEQLNEVIEKLQQ--ELANIGQKTSMNAHSLS 2378
Query: 743 DEAQENKSKMKMV-------EEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSELAD 795
+EA K ++ +V E+ +E E M +K++ E FK+NQL++
Sbjct: 2379 EEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETN-------FKMNQLTQ--- 2428
Query: 796 PLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICP 855
EL E ++ ++ + E +D L+K K EL++ E + S Q
Sbjct: 2429 ----ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTE-DALKSLENQTYF 2483
Query: 856 ERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARETYLDLDSKVRTLKKF 915
+ E SI++ E L Q E E+ + Y++ ++ + L+K
Sbjct: 2484 KSFEENGKGSIINLETRLL----QLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKK 2539
Query: 916 IKLLGEIMEHR 926
I L +I+E +
Sbjct: 2540 IVNLQKIVEEK 2550
Score = 54.3 bits (129), Expect = 6e-07
Identities = 143/815 (17%), Positives = 313/815 (38%), Gaps = 154/815 (18%)
Query: 152 RSYKLKSATGSVVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFM 211
R++K +V ++E L+ ++D + +Q +Q K E +
Sbjct: 407 RNHKDSQFETDIVQRMEQETQRKLEQLRAELD-------EMYGQQIVQMKQELIRQHM-- 457
Query: 212 KATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNL 271
Q+E+MK + ME R+ I E+++ + E + Q +
Sbjct: 458 --AQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDT------NSQK 509
Query: 272 ESLKHEMAWAVVNE--IEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQ 329
E LK E+ + + +++QL + + + ++ R + + EQ+ +LNEA + ++
Sbjct: 510 EKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVE 569
Query: 330 DKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYK----ALKKDDEQLC 385
D LKA++V+ + E E+ + + YK L+K+ +
Sbjct: 570 D------------------LKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVL 611
Query: 386 KRIEELKKSTDQSLEPERL-ERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEE 444
R+ E +++ + L + L ++++S LKE ++ E+ +N IEK K+
Sbjct: 612 DRMAESQEAELERLRTQLLFSHEEELSKLKEDLEI----EHRIN---------IEKLKDN 658
Query: 445 HGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKP 504
G ++++D L Q E + D L + + + D +
Sbjct: 659 LGIHYKQQID---GLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ-------- 707
Query: 505 VGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIV 564
+ ++ + E+ L I ++ ++ L + GT +
Sbjct: 708 -----SLVNSKSEEMTLQINEL---------------QKEIEILRQEEKEKGTLEQEVQE 747
Query: 565 SEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVAN---SLIDMRGIET----------- 610
+ + E+ + + + + D LE +N+++ + +L DM I T
Sbjct: 748 LQLKTELLEKQMKEKEN-DLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
Query: 611 -----------------VLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSE 653
+L+ +N + + +Q + + R F+ ++ F Y +
Sbjct: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSF-AEKNFEVNYQELQ 865
Query: 654 NTRPKFLSRDVDSEISDLENEVENKT-AQILNLQQHLSALE-KDIKHNEELL---KRCQL 708
L D E S + E+E K+ + LN + HL + +K + K
Sbjct: 866 EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA 925
Query: 709 HYKELKMKIRKNISEIRELENIEEHQSVD----IATLEDEAQENKSKMKMVEEHMEQQKE 764
E+ + K+ +E+ E + + + ++ ++ L ++ ++ ++ + E ++ K+
Sbjct: 926 ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985
Query: 765 NMEHLKSLKIEAE-----NKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYE 819
E + E E N+ + ++ Q+S L D + + +E K K E
Sbjct: 986 EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVV-TMTSRGAEGSVSKVNKSFGE 1044
Query: 820 EKQKEHLDTLN---------KKKRELDMKEKELEEKMSQARQICP-ERIEVEKSASILDK 869
E + D ++ K+ +L + K S R P E +++K ++L
Sbjct: 1045 ESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKS 1104
Query: 870 EINRLRQKIQAE-------HASHGDREEIMRQYQE 897
E N LR +++A+ +++H D+ +R+Y E
Sbjct: 1105 EQNDLRLQMEAQRICLSLVYSTHVDQ---VREYME 1136
Score = 53.9 bits (128), Expect = 8e-07
Identities = 66/345 (19%), Positives = 153/345 (44%), Gaps = 47/345 (13%)
Query: 168 KEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIM 227
+ L++ + + Q++ L +E + + E +Y K +Q+ +M+ + S +
Sbjct: 3087 RRSLLSEIQALHAQMNGRKITLKREQESE--KPSQELLEYNIQQKQSQMLEMQVELSSMK 3144
Query: 228 ETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAV-VNEI 286
+ +EQ+ + + ELK + + + ++ T+K + LK A+ + V +
Sbjct: 3145 DRATELQEQLSSEKMVVAELKSELAQTKLELET-----TLKAQHKHLKELEAFRLEVKDK 3199
Query: 287 EKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPEC 346
+++ + D + + ++ L +E+++ +L +E++ K+ +LE + ++
Sbjct: 3200 TDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE---ELEDLKFSLESQKQRN 3256
Query: 347 MALKADVVAKKRAYNEAE-------VLYNRSLNEYKALKKDDEQLCK----RIEELKKST 395
+ L + +K+ NE++ +LY+ L+E + + + L + RI E+ +
Sbjct: 3257 LQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTL 3316
Query: 396 DQSLE-------------------PERL--ERQKKISWLKERVKAFQNQENSVNQEIEQF 434
D+ E E L E QK++ R+ N+ + Q
Sbjct: 3317 DRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQT 3376
Query: 435 QQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKR 479
+Q +EKD++ H K + E + A + Q+++ EL+ SK + L+R
Sbjct: 3377 RQQMEKDRQVHRKTLQTE---QEANTEGQKKMHELQ-SKVEDLQR 3417
Score = 41.2 bits (95), Expect = 0.005
Identities = 141/796 (17%), Positives = 311/796 (39%), Gaps = 99/796 (12%)
Query: 168 KEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQL-EQMKEDYSYI 226
K +L A+ + ++Q NP +V + S F + K F + ++ E +++D + +
Sbjct: 890 KSKLKALNEELHLQRINPTTVKMK--SSVFDEDKT------FVAETLEMGEVVEKDTTEL 941
Query: 227 METKERTKEQIHQGEERLTELKRQCVEKEERF----QSIAGLSTMKTNLESLKHEMAWAV 282
ME E TK + + +RL++L Q +K + + L K + E+ +
Sbjct: 942 MEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIII 1001
Query: 283 -------VNEIEKQLNAIRDNI-----------------KIGEDRAARLDRKMEEQQVRL 318
V + Q++++ D + GE+ ++ K+ + + +
Sbjct: 1002 NHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTV 1061
Query: 319 NEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALK 378
E ++ + I D L +++E++ RA + + E VL + N+ + L+
Sbjct: 1062 GEESKQEQLILDHLPSVTKESSLRATQPSE-------NDKLQKELNVLKSEQ-NDLR-LQ 1112
Query: 379 KDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQF---- 434
+ +++C + DQ E E+ K + LKE + Q ++ Q+I Q
Sbjct: 1113 MEAQRICLSLV-YSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQT 1171
Query: 435 ---QQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAI 491
Q+ ++ K H I + + V SY + L + + + P + + A
Sbjct: 1172 MKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLG------EYYTPALKCEVNA- 1224
Query: 492 DDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKR 551
+D G + + P + + + L + + Y VLQ + +
Sbjct: 1225 EDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEY-----NKLLVLQTRLSK 1279
Query: 552 FYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETV 611
+ T + E N + + H T L +++++ +SL D+ +T
Sbjct: 1280 IWGQQTDGMKLEFGE-ENLPKEETEFLSIHSQM-TNLEDIDVNHKSKLSSLQDLE--KTK 1335
Query: 612 LLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEI--- 668
L + + + Q+ K + + A+ + SE+T P L VDS +
Sbjct: 1336 LEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLP--VDSVVITE 1393
Query: 669 SDLENEVENKTAQILNLQQHLS-ALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIREL 727
SD + + + N+ + + E +K ++K + Y+E ++ + ++++
Sbjct: 1394 SDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQE---QLEEEVAKVIVS 1450
Query: 728 ENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLK----SLKIEAENKYDAI 783
+I Q +++ + +EN + K +Q++ +K + + D +
Sbjct: 1451 MSIAFAQQTELSRISG-GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVD-V 1508
Query: 784 KFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKEL 843
KFK E PL EL E+ H + K+ + T+++ E+ K+K
Sbjct: 1509 KFK-----EEFKPLSKELGEHGKEI-LLSNSDPHDIPESKDCVLTISE---EMFSKDKTF 1559
Query: 844 EEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEI-----MRQYQEA 898
+ S +I ++ + + ++++ +RQ++ ++ H E+ MRQ +
Sbjct: 1560 IVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQ 1619
Query: 899 RETYLDLDSKVRTLKK 914
RE L +++ L +
Sbjct: 1620 REDQEQLQEEIKRLNR 1635
Score = 38.5 bits (88), Expect = 0.035
Identities = 66/333 (19%), Positives = 137/333 (41%), Gaps = 30/333 (9%)
Query: 164 VSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKAT--------- 214
V +EE I L+ ++ ++ + Q+ S E D K +
Sbjct: 2341 VKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ 2400
Query: 215 QLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIA---------GLS 265
Q+E E+ +++ + T +++Q + L LKR+ E E+ QSI LS
Sbjct: 2401 QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRE-RESVEKIQSIPENSVNVAIDHLS 2459
Query: 266 TMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIG----EDRAARLDRKMEEQQVRLNEA 321
K LE + E A + E + + +N K E R +L+ + + + L
Sbjct: 2460 KDKPELEVVLTEDALKSL-ENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELT-- 2516
Query: 322 EQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDD 381
Q YK I+D E+ ET + + L+ +V +K A + ++ EY +D+
Sbjct: 2517 -QCYKQIKDMQEQGQFETEMLQKKIVNLQ-KIVEEKVAAALVSQIQLEAVQEYAKFCQDN 2574
Query: 382 EQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKD 441
+ + E L + L IS L R+ ++Q ++ + ++ +E
Sbjct: 2575 QTISSEPERTNIQNLNQLREDEL--GSDISALTLRISELESQVVEMHTSLILEKEQVEIA 2632
Query: 442 KEEHGKIKREELDVKHALSYNQRQLKELKDSKT 474
++ + +++ L+++ L N+++ +E + ++
Sbjct: 2633 EKNVLEKEKKLLELQKLLEGNEKKQREKEKKRS 2665
Score = 38.1 bits (87), Expect = 0.046
Identities = 64/302 (21%), Positives = 137/302 (45%), Gaps = 45/302 (14%)
Query: 188 VLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTEL 247
++ E+ + Q+K E + +KA Q + +KE ++ +E K++T E + +E
Sbjct: 3159 MVVAELKSELAQTKLE---LETTLKA-QHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQ 3214
Query: 248 KRQ-----CVEKEE------RFQSIAGLSTMKTNLESLKH---------EMAWAVVNEIE 287
K+ +EKE+ + L +K +LES K E ++NE +
Sbjct: 3215 KKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQ 3274
Query: 288 KQLNAIRD--NIKIGEDRAARLDRK--MEEQQVRLNEAEQ---KYKDIQDKLEKISEETN 340
+++ + R + ++ E++ L+ + +E ++VR+ E + +++ +L+
Sbjct: 3275 QKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQ 3334
Query: 341 ARAPECMALKADVVAKK--RAYNEAEVLYNRSLNEYKALKKDDEQLCKRIE---ELKKST 395
+R P L ++ + K+ + E LNE + K D Q +++E ++ + T
Sbjct: 3335 SRPP----LPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKT 3390
Query: 396 DQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQ---QAIEKDKEEHGK--IKR 450
Q+ + E QKK+ L+ +V+ Q Q Q++ + Q ++ +E K ++R
Sbjct: 3391 LQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELER 3450
Query: 451 EE 452
EE
Sbjct: 3451 EE 3452
Score = 37.4 bits (85), Expect = 0.078
Identities = 65/296 (21%), Positives = 121/296 (40%), Gaps = 43/296 (14%)
Query: 661 SRDVDSEIS----DLENEVEN-----KTAQILNLQQHLSALEKDIKHNEELLKRCQLHYK 711
S +++SEIS D +EV +T + NL + D ++E+ + H +
Sbjct: 100 SVELESEISTTADDCSSEVNGCSFVMRTGKPTNLLRE-EEFGVDDSYSEQGAQDSPTHLE 158
Query: 712 ELKMKIRKNISEIRELENIEEHQSVDIATLE-DEAQENKSKMKMVEEHMEQQKENMEHLK 770
++ ++ EI EL E V T + QE ++ +K + + Q N++ +
Sbjct: 159 MMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQAR 218
Query: 771 S---------LKIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEK 821
L++ +++ I+F+ Q SE AD Q+ + +
Sbjct: 219 REKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLE 278
Query: 822 QKEHL-DTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKE--INRLRQKI 878
+++HL + KKK + M+ L+EK+ +++E I +KE I L KI
Sbjct: 279 EQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKI 338
Query: 879 QAEHASHGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFR 934
+E ++T L+L K+ T KLLGE+ E + Q+ +
Sbjct: 339 ----------------IEEEKKT-LELKDKLTTAD---KLLGELQEQIVQKNQEIK 374
Score = 35.4 bits (80), Expect = 0.30
Identities = 33/143 (23%), Positives = 69/143 (48%), Gaps = 16/143 (11%)
Query: 328 IQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKR 387
++ ++++ E A A EC+ KAD ++ +E + L+ + +N K K +++ K
Sbjct: 3064 LEQRIQEQGVEYQA-AMECLQ-KAD---RRSLLSEIQALHAQ-MNGRKITLKREQESEKP 3117
Query: 388 IEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEHGK 447
+EL + Q + + LE Q ++S +K+R Q Q +S + + + + + K
Sbjct: 3118 SQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTK----- 3172
Query: 448 IKREELDVKHALSYNQRQLKELK 470
L+++ L + LKEL+
Sbjct: 3173 -----LELETTLKAQHKHLKELE 3190
Score = 32.3 bits (72), Expect = 2.5
Identities = 76/397 (19%), Positives = 168/397 (42%), Gaps = 53/397 (13%)
Query: 139 SILIQQHISIDGSRSYKLKS------ATGSVVSTRKEELIAILDHFNIQVDNPVSVLTQE 192
++L++Q + K++S A S R EL +L+ +++ S L +E
Sbjct: 3260 NLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRE 3319
Query: 193 --MSKQFLQSKNEGDKY-----KFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLT 245
+ Q S G + +K Q +Q++E +S I+E T++ +L
Sbjct: 3320 RELHAQLQSSDGTGQSRPPLPSEDLLKELQ-KQLEEKHSRIVELLNETEKY------KLD 3372
Query: 246 ELK-RQCVEKEERFQSIAGLSTMKTNLESLK--HEMAWAVVNEIEKQLNAIRDNIKIGED 302
L+ RQ +EK+ + + + N E K HE+ + V ++++QL R + +
Sbjct: 3373 SLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQ-SKVEDLQRQLEEKRQQVYKLDL 3431
Query: 303 RAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEET----NARAPECMALKADVVAKKR 358
RL M+E Q + E E+K + + + ++E T + L+ + + +
Sbjct: 3432 EGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETK 3491
Query: 359 AYNEAEVLYNRS-----LNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWL 413
N A+++ +E + +++ + + +++ L + + L+ E + + I W+
Sbjct: 3492 ESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFI-WV 3550
Query: 414 KERVKAFQNQ-ENSVNQEIEQ-------------FQQAIEKDKEEHGKIKR---EELDVK 456
+E + Q + Q+ E+ ++ + ++ E G I + E+ D++
Sbjct: 3551 QENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLR 3610
Query: 457 HALSYNQRQLKELKDSKT--DRLKRFGPNVPALLEAI 491
+ + + Q++ + + D RF N A +EAI
Sbjct: 3611 NMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAI 3647
Score = 31.6 bits (70), Expect = 4.3
Identities = 66/303 (21%), Positives = 123/303 (40%), Gaps = 33/303 (10%)
Query: 214 TQLEQMKEDYSYIMETKERTKEQIHQGEERL-----TELKRQCVEKEERFQSIAGLSTMK 268
T LE M+ + + K+ E++++ E + TE +Q E E + G+ T
Sbjct: 155 THLEMMESE----LAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQL 210
Query: 269 T-NLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVR--LNEAEQKY 325
T NL+ + E + +E + + I+ + +A+ R L +A+Q+
Sbjct: 211 TANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQI 270
Query: 326 KDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLC 385
Q +LE E + + K D + E +Y E + KK +
Sbjct: 271 LTHQQQLE----EQDHLLEDYQKKKEDFTMQISFLQEKIKVY-----EMEQDKKVENSNK 321
Query: 386 KRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEH 445
+ I+E K++ + L + +E +KK LK+++ + ++I Q Q I+ K E
Sbjct: 322 EEIQE-KETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLEL 380
Query: 446 GKIKREELDVKHALSYNQRQLKEL-----KDS--KTDRLKRFGPNVPALLE----AIDDA 494
K++E + ++EL KDS +TD ++R LE +D+
Sbjct: 381 TNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEM 440
Query: 495 YRQ 497
Y Q
Sbjct: 441 YGQ 443
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 76.6 bits (187), Expect = 1e-13
Identities = 161/795 (20%), Positives = 331/795 (41%), Gaps = 95/795 (11%)
Query: 180 IQVDNPVSVLTQEMSKQ-FLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETK--ERTKEQ 236
+Q + Q++ +Q L + K F M+ + L++ + Y + K KE+
Sbjct: 264 LQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEE 323
Query: 237 IHQGEERLTELKRQCVEKEERFQSIAG-LSTMKTNLESLKHEMAWA--VVNEIEKQLNAI 293
I + E + EL + +E+E++ + L+T L L+ ++ + ++ +L
Sbjct: 324 IQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNS 383
Query: 294 RDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADV 353
+ + + +L +EE Q R ++ Q DI ++E +ET + + A
Sbjct: 384 KQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRME---QETQRKLEQLRA----- 435
Query: 354 VAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWL 413
E + +Y + + + K ++ Q ++EE+K +E L I+
Sbjct: 436 --------ELDEMYGQQIVQMK--QELIRQHMAQMEEMKTRHKGEME-NALRSYSNITVN 484
Query: 414 KERVKAFQNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSK 473
++++K N +N +++ EK KEE G I L+ K AL QRQL++L +
Sbjct: 485 EDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLI----LEEKCAL---QRQLEDLVEEL 537
Query: 474 TDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQA 533
+ ++ + E + + H + V L A I + E +E + +
Sbjct: 538 SFSREQIQRARQTIAEQ-ESKLNEAHKSLSTVEDLKAEI-VSASESRKELELKHEAEVTN 595
Query: 534 YCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEI 593
Y E+ A++ R + R ++ ++ + + LEI
Sbjct: 596 YKIKLEMLEKEKNAVLDRM----AESQEAELERLRTQLL-----FSHEEELSKLKEDLEI 646
Query: 594 DNAVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSE 653
++ + L D GI I +Q++ K F D + +
Sbjct: 647 EHRINIEKLKDNLGIHYKQQIDG-------LQNEMSQKIETMQFEKDN-------LITKQ 692
Query: 654 NTRPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKEL 713
N +S+ D + S + ++ E T QI LQ+ + L ++ K L + Q EL
Sbjct: 693 NQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQ----EL 748
Query: 714 KMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHME-----QQKENMEH 768
++K +++E EN + + A LE E K + K +E+ ++ Q+E +
Sbjct: 749 QLKTELLEKQMKEKENDLQEK---FAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805
Query: 769 LKSLKIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQ--------KRGKRHYEE 820
L S+K +++K + +I L E + LK + + E++ Q K + +Y+E
Sbjct: 806 LDSIK--SKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQE 863
Query: 821 KQKEHL----------DTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKE 870
Q+E+ D+ NK++ E K K L E++ ++I P ++++ +S+ D++
Sbjct: 864 LQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL-HLQRINPTTVKMK--SSVFDED 920
Query: 871 INRLRQKIQAEHASHGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLL-GEI--MEHRF 927
+ + ++ D E+M + + + L+L ++ L + +K GEI +
Sbjct: 921 KTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEV 980
Query: 928 KTYQQFRRCLTLRCK 942
K+ +Q + ++LRC+
Sbjct: 981 KSLKQEKEQVSLRCR 995
Score = 67.0 bits (162), Expect = 9e-11
Identities = 155/771 (20%), Positives = 295/771 (38%), Gaps = 82/771 (10%)
Query: 175 LDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTK 234
+D N ++ +S Q ++ L++ +E K TQ E M+E + E E K
Sbjct: 1835 IDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK 1894
Query: 235 EQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIR 294
Q + ERL E E R Q LS + ++ E E+Q+
Sbjct: 1895 CQ-EELRERLHE------ESRAREQLAVELSKAEGVIDGYADEKTL-----FERQIQEKT 1942
Query: 295 DNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVV 354
D I RL++++ RL E E + + IQ++ E +S + A E ++ ++
Sbjct: 1943 DIID-------RLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLL 1995
Query: 355 A--------KKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLER 406
K +AE + + + KAL+ D E+ R EL++ + L R +
Sbjct: 1996 QETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQN 2055
Query: 407 QKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQL 466
Q L++ K Q E + FQQ I+K +++ + R + +H ++
Sbjct: 2056 QALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLA 2115
Query: 467 KELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIES- 525
LK+ KTD+ + L I + + V L + + D + A+E+
Sbjct: 2116 NHLKE-KTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAK 2174
Query: 526 ---CLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHP 582
L+ LQA E+ + L ++ + +FR E+ + +
Sbjct: 2175 PELSLEVQLQAERDAIDRKEKEITNLEEQ------------LEQFREELEN------KNE 2216
Query: 583 DFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGD 642
+ + LEI L ++ + + A+ +S +
Sbjct: 2217 EVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFA 2276
Query: 643 QVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEEL 702
Q+ + + + +I+ +E K I +L+ + L D +E
Sbjct: 2277 QIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSD----QEC 2332
Query: 703 LKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMV------- 755
+KR + E ++ + + + EL NI + S++ +L +EA K ++ +V
Sbjct: 2333 VKRNREEEIEQLNEVIEKLQQ--ELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLAL 2390
Query: 756 EEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGK 815
E+ +E E M +K++ E FK+NQL++ EL E ++ ++ +
Sbjct: 2391 EQQVETANEEMTFMKNVLKET-------NFKMNQLTQ-------ELFSLKRERESVEKIQ 2436
Query: 816 RHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLR 875
E +D L+K K EL++ E + S Q + E SI++ E L
Sbjct: 2437 SIPENSVNVAIDHLSKDKPELEVVLTE-DALKSLENQTYFKSFEENGKGSIINLETRLL- 2494
Query: 876 QKIQAEHASHGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHR 926
Q E E+ + Y++ ++ + L+K I L +I+E +
Sbjct: 2495 ---QLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEK 2542
Score = 66.2 bits (160), Expect = 2e-10
Identities = 144/760 (18%), Positives = 295/760 (38%), Gaps = 96/760 (12%)
Query: 169 EELIAILDHFNIQVDNPVSVLTQEMSKQFLQSK--------NEGDKYKFFMKATQLEQMK 220
E++ LD I ++ V QE+ K Q K +E + A L++
Sbjct: 2063 EKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKT 2122
Query: 221 EDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAW 280
+ S ++ +KE+ + I + E + +L+ + E E+ +E KH A
Sbjct: 2123 DKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALL-----------VEDRKHFGAV 2171
Query: 281 AVVNEI--EKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEE 338
E+ E QL A RD I E L+ ++E+ + L ++ + + +LE +E
Sbjct: 2172 EAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKE 2231
Query: 339 TNARAPEC----MALKADVVAKKRAYNEAE--------VLYNR--SLNEYKALKKD--DE 382
+ R E K D+ A E++ VL+ + + + K ++ D +E
Sbjct: 2232 STTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNE 2291
Query: 383 QLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVN----QEIEQFQQAI 438
Q+ K ++LK +TD + E+ E I L+ +++ + + V +EIEQ + I
Sbjct: 2292 QVTKLQQQLKITTDNKVIEEKNEL---IRDLETQIECLMSDQECVKRNREEEIEQLNEVI 2348
Query: 439 EKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQG 498
E K+++E ++ S N L E DS +L AL + ++ A +
Sbjct: 2349 E-------KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEM 2401
Query: 499 HFTYKPVGPLGACIH---------LRDPELALAIESCLKGLLQAYCCHNHADERVLQALM 549
F + ++ R+ E I+S + + H D+ L+ ++
Sbjct: 2402 TFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVL 2461
Query: 550 KRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMR--- 606
L S N + + + ++A +++ + DM+
Sbjct: 2462 TEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQG 2521
Query: 607 GIETVLL----------IKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTR 656
ET +L ++ A V Q Q F D + + ++
Sbjct: 2522 QFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNL 2581
Query: 657 PKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMK 716
+ ++ S+IS L + +Q++ + L ++ ++ E+ + + EL+
Sbjct: 2582 NQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKL 2641
Query: 717 IRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEA 776
+ N + RE E Q V++ E H ++ L++L+ E+
Sbjct: 2642 LEGNEKKQREKEKKRSPQDVEVLKTTTEL-----------FHSNEESGFFNELEALRAES 2690
Query: 777 ENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKREL 836
A K ++ E A+ L++EL + ++ + + ++ + D L + K +L
Sbjct: 2691 V----ATKAELASYKEKAEKLQEELLVKETNMTS-------LQKDLSQVRDHLAEAKEKL 2739
Query: 837 DMKEKELEEKMSQARQICP-ERIEVEKSASILDKEINRLR 875
+ EKE E ++ ++++ C E + ++ S SI + L+
Sbjct: 2740 SILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLK 2779
Score = 54.3 bits (129), Expect = 6e-07
Identities = 143/815 (17%), Positives = 313/815 (38%), Gaps = 154/815 (18%)
Query: 152 RSYKLKSATGSVVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFM 211
R++K +V ++E L+ ++D + +Q +Q K E +
Sbjct: 407 RNHKDSQFETDIVQRMEQETQRKLEQLRAELD-------EMYGQQIVQMKQELIRQHM-- 457
Query: 212 KATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNL 271
Q+E+MK + ME R+ I E+++ + E + Q +
Sbjct: 458 --AQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDT------NSQK 509
Query: 272 ESLKHEMAWAVVNE--IEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQ 329
E LK E+ + + +++QL + + + ++ R + + EQ+ +LNEA + ++
Sbjct: 510 EKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVE 569
Query: 330 DKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYK----ALKKDDEQLC 385
D LKA++V+ + E E+ + + YK L+K+ +
Sbjct: 570 D------------------LKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVL 611
Query: 386 KRIEELKKSTDQSLEPERL-ERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEE 444
R+ E +++ + L + L ++++S LKE ++ E+ +N IEK K+
Sbjct: 612 DRMAESQEAELERLRTQLLFSHEEELSKLKEDLEI----EHRIN---------IEKLKDN 658
Query: 445 HGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKP 504
G ++++D L Q E + D L + + + D +
Sbjct: 659 LGIHYKQQID---GLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ-------- 707
Query: 505 VGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIV 564
+ ++ + E+ L I ++ ++ L + GT +
Sbjct: 708 -----SLVNSKSEEMTLQINEL---------------QKEIEILRQEEKEKGTLEQEVQE 747
Query: 565 SEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVAN---SLIDMRGIET----------- 610
+ + E+ + + + + D LE +N+++ + +L DM I T
Sbjct: 748 LQLKTELLEKQMKEKEN-DLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
Query: 611 -----------------VLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSE 653
+L+ +N + + +Q + + R F+ ++ F Y +
Sbjct: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSF-AEKNFEVNYQELQ 865
Query: 654 NTRPKFLSRDVDSEISDLENEVENKT-AQILNLQQHLSALE-KDIKHNEELL---KRCQL 708
L D E S + E+E K+ + LN + HL + +K + K
Sbjct: 866 EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA 925
Query: 709 HYKELKMKIRKNISEIRELENIEEHQSVD----IATLEDEAQENKSKMKMVEEHMEQQKE 764
E+ + K+ +E+ E + + + ++ ++ L ++ ++ ++ + E ++ K+
Sbjct: 926 ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985
Query: 765 NMEHLKSLKIEAE-----NKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYE 819
E + E E N+ + ++ Q+S L D + + +E K K E
Sbjct: 986 EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVV-TMTSRGAEGSVSKVNKSFGE 1044
Query: 820 EKQKEHLDTLN---------KKKRELDMKEKELEEKMSQARQICP-ERIEVEKSASILDK 869
E + D ++ K+ +L + K S R P E +++K ++L
Sbjct: 1045 ESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKS 1104
Query: 870 EINRLRQKIQAE-------HASHGDREEIMRQYQE 897
E N LR +++A+ +++H D+ +R+Y E
Sbjct: 1105 EQNDLRLQMEAQRICLSLVYSTHVDQ---VREYME 1136
Score = 53.9 bits (128), Expect = 8e-07
Identities = 66/345 (19%), Positives = 153/345 (44%), Gaps = 47/345 (13%)
Query: 168 KEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIM 227
+ L++ + + Q++ L +E + + E +Y K +Q+ +M+ + S +
Sbjct: 3079 RRSLLSEIQALHAQMNGRKITLKREQESE--KPSQELLEYNIQQKQSQMLEMQVELSSMK 3136
Query: 228 ETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAV-VNEI 286
+ +EQ+ + + ELK + + + ++ T+K + LK A+ + V +
Sbjct: 3137 DRATELQEQLSSEKMVVAELKSELAQTKLELET-----TLKAQHKHLKELEAFRLEVKDK 3191
Query: 287 EKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPEC 346
+++ + D + + ++ L +E+++ +L +E++ K+ +LE + ++
Sbjct: 3192 TDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE---ELEDLKFSLESQKQRN 3248
Query: 347 MALKADVVAKKRAYNEAE-------VLYNRSLNEYKALKKDDEQLCK----RIEELKKST 395
+ L + +K+ NE++ +LY+ L+E + + + L + RI E+ +
Sbjct: 3249 LQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTL 3308
Query: 396 DQSLE-------------------PERL--ERQKKISWLKERVKAFQNQENSVNQEIEQF 434
D+ E E L E QK++ R+ N+ + Q
Sbjct: 3309 DRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQT 3368
Query: 435 QQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKR 479
+Q +EKD++ H K + E + A + Q+++ EL+ SK + L+R
Sbjct: 3369 RQQMEKDRQVHRKTLQTE---QEANTEGQKKMHELQ-SKVEDLQR 3409
Score = 50.1 bits (118), Expect = 1e-05
Identities = 67/332 (20%), Positives = 137/332 (41%), Gaps = 51/332 (15%)
Query: 657 PKF--LSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELK 714
P+F +S E+ L N ++ KT + L L++DI+ E +++ + +EL+
Sbjct: 2098 PRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE 2157
Query: 715 MKI----RKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLK 770
+ RK+ + + V + D + ++ +EE +EQ +E +E+
Sbjct: 2158 QALLVEDRKHFGAVEAKPELS--LEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKN 2215
Query: 771 S------LKIEAENKYDAIKF-KINQLSELADPLKDELNLADSEVDNQKRGKRH------ 817
+++E + K + ++ Q ++L ++L LA E D +H
Sbjct: 2216 EEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKF 2275
Query: 818 ---YEEKQKEHLDTLNKKKRELDMK------EKELEEKMSQAR------------QICPE 856
+EK+ E +D LN++ +L + K +EEK R Q C +
Sbjct: 2276 AQIIQEKEVE-IDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVK 2334
Query: 857 R---IEVEKSASILDK---EINRLRQKIQAE-HASHGDREEIMRQYQEARETYLDLDSKV 909
R E+E+ +++K E+ + QK H+ + + + Q L L+ +V
Sbjct: 2335 RNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQV 2394
Query: 910 RTLKKFIKLLGEIM-EHRFKTYQQFRRCLTLR 940
T + + + ++ E FK Q + +L+
Sbjct: 2395 ETANEEMTFMKNVLKETNFKMNQLTQELFSLK 2426
Score = 41.2 bits (95), Expect = 0.005
Identities = 141/796 (17%), Positives = 311/796 (39%), Gaps = 99/796 (12%)
Query: 168 KEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQL-EQMKEDYSYI 226
K +L A+ + ++Q NP +V + S F + K F + ++ E +++D + +
Sbjct: 890 KSKLKALNEELHLQRINPTTVKMK--SSVFDEDKT------FVAETLEMGEVVEKDTTEL 941
Query: 227 METKERTKEQIHQGEERLTELKRQCVEKEERF----QSIAGLSTMKTNLESLKHEMAWAV 282
ME E TK + + +RL++L Q +K + + L K + E+ +
Sbjct: 942 MEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIII 1001
Query: 283 -------VNEIEKQLNAIRDNI-----------------KIGEDRAARLDRKMEEQQVRL 318
V + Q++++ D + GE+ ++ K+ + + +
Sbjct: 1002 NHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTV 1061
Query: 319 NEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALK 378
E ++ + I D L +++E++ RA + + E VL + N+ + L+
Sbjct: 1062 GEESKQEQLILDHLPSVTKESSLRATQPSE-------NDKLQKELNVLKSEQ-NDLR-LQ 1112
Query: 379 KDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQF---- 434
+ +++C + DQ E E+ K + LKE + Q ++ Q+I Q
Sbjct: 1113 MEAQRICLSLV-YSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQT 1171
Query: 435 ---QQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAI 491
Q+ ++ K H I + + V SY + L + + + P + + A
Sbjct: 1172 MKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLG------EYYTPALKCEVNA- 1224
Query: 492 DDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKR 551
+D G + + P + + + L + + Y VLQ + +
Sbjct: 1225 EDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEY-----NKLLVLQTRLSK 1279
Query: 552 FYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETV 611
+ T + E N + + H T L +++++ +SL D+ +T
Sbjct: 1280 IWGQQTDGMKLEFGE-ENLPKEETEFLSIHSQM-TNLEDIDVNHKSKLSSLQDLE--KTK 1335
Query: 612 LLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEI--- 668
L + + + Q+ K + + A+ + SE+T P L VDS +
Sbjct: 1336 LEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLP--VDSVVITE 1393
Query: 669 SDLENEVENKTAQILNLQQHLS-ALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIREL 727
SD + + + N+ + + E +K ++K + Y+E ++ + ++++
Sbjct: 1394 SDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQE---QLEEEVAKVIVS 1450
Query: 728 ENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLK----SLKIEAENKYDAI 783
+I Q +++ + +EN + K +Q++ +K + + D +
Sbjct: 1451 MSIAFAQQTELSRISG-GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVD-V 1508
Query: 784 KFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKEL 843
KFK E PL EL E+ H + K+ + T+++ E+ K+K
Sbjct: 1509 KFK-----EEFKPLSKELGEHGKEI-LLSNSDPHDIPESKDCVLTISE---EMFSKDKTF 1559
Query: 844 EEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEI-----MRQYQEA 898
+ S +I ++ + + ++++ +RQ++ ++ H E+ MRQ +
Sbjct: 1560 IVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQ 1619
Query: 899 RETYLDLDSKVRTLKK 914
RE L +++ L +
Sbjct: 1620 REDQEQLQEEIKRLNR 1635
Score = 38.5 bits (88), Expect = 0.035
Identities = 66/333 (19%), Positives = 137/333 (41%), Gaps = 30/333 (9%)
Query: 164 VSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKAT--------- 214
V +EE I L+ ++ ++ + Q+ S E D K +
Sbjct: 2333 VKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ 2392
Query: 215 QLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIA---------GLS 265
Q+E E+ +++ + T +++Q + L LKR+ E E+ QSI LS
Sbjct: 2393 QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRE-RESVEKIQSIPENSVNVAIDHLS 2451
Query: 266 TMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIG----EDRAARLDRKMEEQQVRLNEA 321
K LE + E A + E + + +N K E R +L+ + + + L
Sbjct: 2452 KDKPELEVVLTEDALKSL-ENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELT-- 2508
Query: 322 EQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDD 381
Q YK I+D E+ ET + + L+ +V +K A + ++ EY +D+
Sbjct: 2509 -QCYKQIKDMQEQGQFETEMLQKKIVNLQ-KIVEEKVAAALVSQIQLEAVQEYAKFCQDN 2566
Query: 382 EQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKD 441
+ + E L + L IS L R+ ++Q ++ + ++ +E
Sbjct: 2567 QTISSEPERTNIQNLNQLREDEL--GSDISALTLRISELESQVVEMHTSLILEKEQVEIA 2624
Query: 442 KEEHGKIKREELDVKHALSYNQRQLKELKDSKT 474
++ + +++ L+++ L N+++ +E + ++
Sbjct: 2625 EKNVLEKEKKLLELQKLLEGNEKKQREKEKKRS 2657
Score = 38.1 bits (87), Expect = 0.046
Identities = 64/302 (21%), Positives = 137/302 (45%), Gaps = 45/302 (14%)
Query: 188 VLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTEL 247
++ E+ + Q+K E + +KA Q + +KE ++ +E K++T E + +E
Sbjct: 3151 MVVAELKSELAQTKLE---LETTLKA-QHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQ 3206
Query: 248 KRQ-----CVEKEE------RFQSIAGLSTMKTNLESLKH---------EMAWAVVNEIE 287
K+ +EKE+ + L +K +LES K E ++NE +
Sbjct: 3207 KKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQ 3266
Query: 288 KQLNAIRD--NIKIGEDRAARLDRK--MEEQQVRLNEAEQ---KYKDIQDKLEKISEETN 340
+++ + R + ++ E++ L+ + +E ++VR+ E + +++ +L+
Sbjct: 3267 QKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQ 3326
Query: 341 ARAPECMALKADVVAKK--RAYNEAEVLYNRSLNEYKALKKDDEQLCKRIE---ELKKST 395
+R P L ++ + K+ + E LNE + K D Q +++E ++ + T
Sbjct: 3327 SRPP----LPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKT 3382
Query: 396 DQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQ---QAIEKDKEEHGK--IKR 450
Q+ + E QKK+ L+ +V+ Q Q Q++ + Q ++ +E K ++R
Sbjct: 3383 LQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELER 3442
Query: 451 EE 452
EE
Sbjct: 3443 EE 3444
Score = 37.4 bits (85), Expect = 0.078
Identities = 65/296 (21%), Positives = 121/296 (40%), Gaps = 43/296 (14%)
Query: 661 SRDVDSEIS----DLENEVEN-----KTAQILNLQQHLSALEKDIKHNEELLKRCQLHYK 711
S +++SEIS D +EV +T + NL + D ++E+ + H +
Sbjct: 100 SVELESEISTTADDCSSEVNGCSFVMRTGKPTNLLRE-EEFGVDDSYSEQGAQDSPTHLE 158
Query: 712 ELKMKIRKNISEIRELENIEEHQSVDIATLE-DEAQENKSKMKMVEEHMEQQKENMEHLK 770
++ ++ EI EL E V T + QE ++ +K + + Q N++ +
Sbjct: 159 MMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQAR 218
Query: 771 S---------LKIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEK 821
L++ +++ I+F+ Q SE AD Q+ + +
Sbjct: 219 REKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLE 278
Query: 822 QKEHL-DTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKE--INRLRQKI 878
+++HL + KKK + M+ L+EK+ +++E I +KE I L KI
Sbjct: 279 EQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKI 338
Query: 879 QAEHASHGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFR 934
+E ++T L+L K+ T KLLGE+ E + Q+ +
Sbjct: 339 ----------------IEEEKKT-LELKDKLTTAD---KLLGELQEQIVQKNQEIK 374
Score = 35.4 bits (80), Expect = 0.30
Identities = 33/143 (23%), Positives = 69/143 (48%), Gaps = 16/143 (11%)
Query: 328 IQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKR 387
++ ++++ E A A EC+ KAD ++ +E + L+ + +N K K +++ K
Sbjct: 3056 LEQRIQEQGVEYQA-AMECLQ-KAD---RRSLLSEIQALHAQ-MNGRKITLKREQESEKP 3109
Query: 388 IEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEHGK 447
+EL + Q + + LE Q ++S +K+R Q Q +S + + + + + K
Sbjct: 3110 SQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTK----- 3164
Query: 448 IKREELDVKHALSYNQRQLKELK 470
L+++ L + LKEL+
Sbjct: 3165 -----LELETTLKAQHKHLKELE 3182
Score = 32.3 bits (72), Expect = 2.5
Identities = 76/397 (19%), Positives = 168/397 (42%), Gaps = 53/397 (13%)
Query: 139 SILIQQHISIDGSRSYKLKS------ATGSVVSTRKEELIAILDHFNIQVDNPVSVLTQE 192
++L++Q + K++S A S R EL +L+ +++ S L +E
Sbjct: 3252 NLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRE 3311
Query: 193 --MSKQFLQSKNEGDKY-----KFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLT 245
+ Q S G + +K Q +Q++E +S I+E T++ +L
Sbjct: 3312 RELHAQLQSSDGTGQSRPPLPSEDLLKELQ-KQLEEKHSRIVELLNETEKY------KLD 3364
Query: 246 ELK-RQCVEKEERFQSIAGLSTMKTNLESLK--HEMAWAVVNEIEKQLNAIRDNIKIGED 302
L+ RQ +EK+ + + + N E K HE+ + V ++++QL R + +
Sbjct: 3365 SLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQ-SKVEDLQRQLEEKRQQVYKLDL 3423
Query: 303 RAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEET----NARAPECMALKADVVAKKR 358
RL M+E Q + E E+K + + + ++E T + L+ + + +
Sbjct: 3424 EGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETK 3483
Query: 359 AYNEAEVLYNRS-----LNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWL 413
N A+++ +E + +++ + + +++ L + + L+ E + + I W+
Sbjct: 3484 ESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFI-WV 3542
Query: 414 KERVKAFQNQ-ENSVNQEIEQ-------------FQQAIEKDKEEHGKIKR---EELDVK 456
+E + Q + Q+ E+ ++ + ++ E G I + E+ D++
Sbjct: 3543 QENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLR 3602
Query: 457 HALSYNQRQLKELKDSKT--DRLKRFGPNVPALLEAI 491
+ + + Q++ + + D RF N A +EAI
Sbjct: 3603 NMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAI 3639
Score = 31.6 bits (70), Expect = 4.3
Identities = 66/303 (21%), Positives = 123/303 (40%), Gaps = 33/303 (10%)
Query: 214 TQLEQMKEDYSYIMETKERTKEQIHQGEERL-----TELKRQCVEKEERFQSIAGLSTMK 268
T LE M+ + + K+ E++++ E + TE +Q E E + G+ T
Sbjct: 155 THLEMMESE----LAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQL 210
Query: 269 T-NLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVR--LNEAEQKY 325
T NL+ + E + +E + + I+ + +A+ R L +A+Q+
Sbjct: 211 TANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQI 270
Query: 326 KDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLC 385
Q +LE E + + K D + E +Y E + KK +
Sbjct: 271 LTHQQQLE----EQDHLLEDYQKKKEDFTMQISFLQEKIKVY-----EMEQDKKVENSNK 321
Query: 386 KRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEH 445
+ I+E K++ + L + +E +KK LK+++ + ++I Q Q I+ K E
Sbjct: 322 EEIQE-KETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLEL 380
Query: 446 GKIKREELDVKHALSYNQRQLKEL-----KDS--KTDRLKRFGPNVPALLE----AIDDA 494
K++E + ++EL KDS +TD ++R LE +D+
Sbjct: 381 TNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEM 440
Query: 495 YRQ 497
Y Q
Sbjct: 441 YGQ 443
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 76.3 bits (186), Expect = 2e-13
Identities = 155/771 (20%), Positives = 309/771 (40%), Gaps = 146/771 (18%)
Query: 185 PVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERL 244
P T ++++L S N D T K + +T + +EQ+H +
Sbjct: 393 PFVGFTYYSNRRYLSSANPNDN------RTSSNADKSLQESLQKTIYKLEEQLHNEMQLK 446
Query: 245 TELKRQC----VEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIG 300
E++++C ++ ++ + + + NLES V++IEK+ ++ I
Sbjct: 447 DEMEQKCRTSNIKLDKIMKELDEEGNQRRNLES--------TVSQIEKEKMLLQHRIN-- 496
Query: 301 EDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLE---KISEETNA-------------RAP 344
RK E++ + E + ++D+LE K+S+ + A
Sbjct: 497 -----EYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEAN 551
Query: 345 ECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQS------ 398
+ + ++D + R ++ ++S+++ ++L ++ ++ + +E K TD+
Sbjct: 552 DLLRTESDTAVRLR---KSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQA 608
Query: 399 -LEPERLER----------QKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEHGK 447
LE ER +R Q +I+ L+E VK ++ V E ++ Q + ++E
Sbjct: 609 ILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNN 668
Query: 448 IKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGP 507
+ E+D L+Y + L++ + + + K + ++I++A K V
Sbjct: 669 L---EID----LNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEA--------KSVAM 713
Query: 508 LGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEF 567
L++ A E ++Q + D + Q+ K +L G + E
Sbjct: 714 CEMEKKLKEEREAR--EKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKER--MEDEV 769
Query: 568 RNEIYDVRHRAAYHPDFPTVLT--ALEIDNAVVANSLIDMRGIETVLLIKNNSVARA--- 622
+N + + L A E DN ++G+E + + N++ A
Sbjct: 770 KNLTLQLEQESNKRLLLQNELKTQAFEADN---------LKGLEKQMKQEINTLLEAKRL 820
Query: 623 ----VMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENK 678
+ Q K + DQ+ A +Y+S T K +++ EI + E K
Sbjct: 821 LEFELAQLTKQYRGNEGQMRELQDQLEAEQYFS---TLYKTQVKELKEEIEEKNRENLKK 877
Query: 679 TAQILNLQQHLSALEKDI---KHNEELLKRCQLH--YKELKMKIRKNISEIRE------- 726
++ N ++ L A + D+ K E L R L Y EL + +K S R+
Sbjct: 878 IQELQNEKETL-ATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDH 936
Query: 727 -LENIEEHQSV---DIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDA 782
+ +EE S+ DI L E +E KMK EE + +KE E + +LK E
Sbjct: 937 TVSRLEEANSMLTKDIEILRRENEELTEKMKKAEEEYKLEKE--EEISNLKAAFEKN--- 991
Query: 783 IKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMK--- 839
I + ++ + L + +N D ++D +K + +K+KE+ R+L ++
Sbjct: 992 INTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKEN--------RKLQLELNQ 1043
Query: 840 ------------EKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKI 878
+KEL + +Q + C R E++ + + +I +LR K+
Sbjct: 1044 EREKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQLASKESDIEQLRAKL 1094
Score = 55.8 bits (133), Expect = 2e-07
Identities = 64/279 (22%), Positives = 129/279 (46%), Gaps = 41/279 (14%)
Query: 662 RDVDSEISDLENEVENKTAQILNLQ---QHLSALEKDIKHNEELLKR---CQLHYKELKM 715
R+V++E+S L++++E+ N Q + LS L+K ++ +LL+ + ++
Sbjct: 510 RNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHT 569
Query: 716 KIRKNISEI-----------RELENIEEHQSVDI----ATLEDEAQENKSKMKMV----- 755
++ K+IS++ R LEN + D A LE E ++ +M+
Sbjct: 570 EMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQA 629
Query: 756 -----EEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLS-ELADPLKDELNLADSEVD 809
+E ++ K N+E ++ + EA++ + + + N L +L LK + EV+
Sbjct: 630 RITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVN 689
Query: 810 NQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDK 869
K K +K + + + E++ K KE E +A +++EK S+LD
Sbjct: 690 EHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAEN---RVVQIEKQCSMLDV 746
Query: 870 EINRLRQKIQAEHASHGDREEIMRQYQEARETYLDLDSK 908
++ + +QK+ EH + G++E R E + L L+ +
Sbjct: 747 DLKQSQQKL--EHLT-GNKE---RMEDEVKNLTLQLEQE 779
Score = 54.7 bits (130), Expect = 5e-07
Identities = 49/240 (20%), Positives = 113/240 (47%), Gaps = 13/240 (5%)
Query: 668 ISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIREL 727
I++ + + E + + N++ +S L+ ++ +++ + QL ++L +++K + E +L
Sbjct: 495 INEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLS-QLQKQLEEANDL 553
Query: 728 ENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAI---- 783
E +V + E ++ S+++ + ++++ +E+ KS + + AI
Sbjct: 554 LRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAE 613
Query: 784 KFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKEL 843
+ SE+ L+ + EV + K E ++KE D LN ++E + E +L
Sbjct: 614 RRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDL 673
Query: 844 EEKMSQARQICPERIEVEK--SASILDKEINRLRQKI-QAEHASHGDREEIMRQYQEARE 900
K+ +Q + + K A + DK Q I +A+ + + E+ +++ +EARE
Sbjct: 674 NYKLKSLQQRLEQEVNEHKVTKARLTDK-----HQSIEEAKSVAMCEMEKKLKEEREARE 728
Score = 51.6 bits (122), Expect = 4e-06
Identities = 75/348 (21%), Positives = 153/348 (43%), Gaps = 50/348 (14%)
Query: 169 EELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKN------EGDKYKFFMKATQLEQMKED 222
E L + +V N L QE +K+ L E D K K QMK++
Sbjct: 756 EHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEK-----QMKQE 810
Query: 223 YSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTM-KTNLESLKHEMA-- 279
+ ++E K + ++ Q ++ + Q E +++ ++ ST+ KT ++ LK E+
Sbjct: 811 INTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEK 870
Query: 280 ----WAVVNEIEKQLNAIRDNIKIGEDRAA--RLDRKM-EEQQVRLNEAEQKY-----KD 327
+ E++ + + + + E +A +L R + EEQ L + +K ++
Sbjct: 871 NRENLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQE 930
Query: 328 IQDKLEKIS--EETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLC 385
I DK +S EE N+ L D+ +R E ++ EYK K+++
Sbjct: 931 ITDKDHTVSRLEEANSM------LTKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNL 984
Query: 386 KRIEELKKSTDQSLEPE--------------RLERQKKISW-LKERVKAFQNQENSVNQE 430
K E +T+++L+ + +++R+K + L+++ K + + +NQE
Sbjct: 985 KAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQE 1044
Query: 431 IEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLK 478
E+F Q + K ++E ++ + ++ + Q QL K+S ++L+
Sbjct: 1045 REKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQLAS-KESDIEQLR 1091
Score = 35.8 bits (81), Expect = 0.23
Identities = 33/178 (18%), Positives = 78/178 (43%), Gaps = 22/178 (12%)
Query: 748 NKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSELADPLKDELNLADSE 807
+KS + +++ + + +E + + LK E E K K++++ + E
Sbjct: 421 DKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMK--------------E 466
Query: 808 VDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASIL 867
+D + +R+ E T+++ ++E + + + E +A Q +R VE S L
Sbjct: 467 LDEEGNQRRNLES-------TVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTL 519
Query: 868 DKEINRLRQKIQAEHASHGDREEIMRQYQEARETY-LDLDSKVRTLKKFIKLLGEIME 924
++ L++ Q ++ ++ +Q +EA + + D+ VR K ++ I +
Sbjct: 520 KDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQ 577
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.360
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,344,194
Number of Sequences: 37866
Number of extensions: 1735577
Number of successful extensions: 23915
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 390
Number of HSP's successfully gapped in prelim test: 1128
Number of HSP's that attempted gapping in prelim test: 10271
Number of HSP's gapped (non-prelim): 8675
length of query: 1091
length of database: 18,247,518
effective HSP length: 113
effective length of query: 978
effective length of database: 13,968,660
effective search space: 13661349480
effective search space used: 13661349480
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.