BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|4759276 RNA, U3 small nucleolar interacting protein 2 [Homo sapiens] (475 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|4759276 RNA, U3 small nucleolar interacting protein 2 [Homo s... 951 0.0 gi|113865883 WD repeat domain 38 [Homo sapiens] 99 6e-21 gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 99 1e-20 gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 99 1e-20 gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 99 1e-20 gi|4502477 beta-transducin repeat containing protein isoform 2 [... 92 8e-19 gi|16117783 beta-transducin repeat containing protein isoform 1 ... 92 8e-19 gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 89 1e-17 gi|16554629 WD repeat domain 5 [Homo sapiens] 86 7e-17 gi|16554627 WD repeat domain 5 [Homo sapiens] 86 7e-17 gi|157266266 WD repeat domain 86 [Homo sapiens] 85 1e-16 gi|21071067 TBP-associated factor 5 [Homo sapiens] 84 3e-16 gi|23199987 WD repeat domain 5B [Homo sapiens] 82 8e-16 gi|21536371 telomerase-associated protein 1 [Homo sapiens] 82 1e-15 gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 81 2e-15 gi|5174447 guanine nucleotide binding protein (G protein), beta ... 80 4e-15 gi|26665869 WD repeat domain 51B [Homo sapiens] 80 4e-15 gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 79 7e-15 gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [... 79 7e-15 gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 79 9e-15 gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 78 2e-14 gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 78 2e-14 gi|19913369 transducin beta-like 3 [Homo sapiens] 77 3e-14 gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 77 3e-14 gi|72534670 phospholipase A2-activating protein [Homo sapiens] 76 8e-14 gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H... 75 1e-13 gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 75 2e-13 gi|32189425 WD repeat domain 69 [Homo sapiens] 75 2e-13 gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 74 2e-13 gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 74 3e-13 >gi|4759276 RNA, U3 small nucleolar interacting protein 2 [Homo sapiens] Length = 475 Score = 951 bits (2459), Expect = 0.0 Identities = 475/475 (100%), Positives = 475/475 (100%) Query: 1 MSATAAARKRGKPASGAGAGAGAGKRRRKADSAGDRGKSKGGGKMNEEISSDSESESLAP 60 MSATAAARKRGKPASGAGAGAGAGKRRRKADSAGDRGKSKGGGKMNEEISSDSESESLAP Sbjct: 1 MSATAAARKRGKPASGAGAGAGAGKRRRKADSAGDRGKSKGGGKMNEEISSDSESESLAP 60 Query: 61 RKPEEEEEEELEETAQEKKLRLAKLYLEQLRQQEEEKAEARAFEEDQVAGRLKEDVLEQR 120 RKPEEEEEEELEETAQEKKLRLAKLYLEQLRQQEEEKAEARAFEEDQVAGRLKEDVLEQR Sbjct: 61 RKPEEEEEEELEETAQEKKLRLAKLYLEQLRQQEEEKAEARAFEEDQVAGRLKEDVLEQR 120 Query: 121 GRLQKLVAKEIQAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRK 180 GRLQKLVAKEIQAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRK Sbjct: 121 GRLQKLVAKEIQAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRK 180 Query: 181 LHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGH 240 LHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGH Sbjct: 181 LHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGH 240 Query: 241 RDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTA 300 RDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTA Sbjct: 241 RDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTA 300 Query: 301 GGRDGTVRVWKIPEESQLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLAL 360 GGRDGTVRVWKIPEESQLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLAL Sbjct: 301 GGRDGTVRVWKIPEESQLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLAL 360 Query: 361 QREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPL 420 QREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPL Sbjct: 361 QREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPL 420 Query: 421 VGFINSLKFSSSGDFLVAGVGQEHRLGRWWRIKEARNSVCIIPLRRVPVPPAAGS 475 VGFINSLKFSSSGDFLVAGVGQEHRLGRWWRIKEARNSVCIIPLRRVPVPPAAGS Sbjct: 421 VGFINSLKFSSSGDFLVAGVGQEHRLGRWWRIKEARNSVCIIPLRRVPVPPAAGS 475 >gi|113865883 WD repeat domain 38 [Homo sapiens] Length = 314 Score = 99.4 bits (246), Expect = 6e-21 Identities = 73/319 (22%), Positives = 134/319 (42%), Gaps = 32/319 (10%) Query: 134 PASADIRVLR---GHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKG 190 PA+ +R ++ H + +PD + + ++D + W SG+ L + Sbjct: 6 PATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLG----- 60 Query: 191 AEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFR 250 GH+ V S DG AS + +W+ + L GH+ +V ++F Sbjct: 61 ------GHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFS 114 Query: 251 RGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVW 310 + QL S D+ V +W+V + L GH+D++ + D C+ G D TV +W Sbjct: 115 PDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIW 174 Query: 311 KI----PEESQLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHG 366 + P S GH +I C+ + SG+ D ++ +W + L +Q + H Sbjct: 175 DLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTS-SLLIQLKGH- 232 Query: 367 LRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPLVGFINS 426 W+ S+A + +A+ +S V++W C G + L+ L + + ++ Sbjct: 233 ---------VTWVKSIAFSPDELWLASAGYSRMVKVWDCNTG-KCLETLKGV--LDVAHT 280 Query: 427 LKFSSSGDFLVAGVGQEHR 445 F+ G LV+G + R Sbjct: 281 CAFTPDGKILVSGAADQTR 299 >gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo sapiens] Length = 589 Score = 98.6 bits (244), Expect = 1e-20 Identities = 62/218 (28%), Positives = 112/218 (51%), Gaps = 24/218 (11%) Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 198 I L GH ++ C+ + + + S ++D ++ W +E+G+ LHV+ GH Sbjct: 336 IHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQCLHVL-----------MGH 382 Query: 199 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYS 258 + V C + DG+ + SG ++ +W+ ++ L+T GH + V L F G H + S Sbjct: 383 VAAVRC--VQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF-DGIH-VVS 438 Query: 259 TSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL 318 S D S++VW+V + + TL GHQ + ++ ++ + +G D TV++W I L Sbjct: 439 GSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCL 496 Query: 319 -VFYG---HQGSIDCIHLINEEHMVSGADDGSVALWGL 352 G HQ ++ C+ N+ +++ +DDG+V LW L Sbjct: 497 QTLQGPNKHQSAVTCLQ-FNKNFVITSSDDGTVKLWDL 533 Score = 77.0 bits (188), Expect = 3e-14 Identities = 60/213 (28%), Positives = 88/213 (41%), Gaps = 20/213 (9%) Query: 197 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQL 256 GH HV+ + G + SG + +W A + + L T GH V R + Sbjct: 260 GHDDHVIT-CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNI--I 316 Query: 257 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEES 316 S S DR++KVWN + TL+GH V + E V +G RD T+RVW I Sbjct: 317 ISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQ 374 Query: 317 QL-VFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQ 375 L V GH ++ C+ + +VSGA D V +W + L H L+G Sbjct: 375 CLHVLMGHVAAVRCVQ-YDGRRVVSGAYDFMVKVWDPETETCL------HTLQGHTNRVY 427 Query: 376 PFWISSVAALLNTDLVATGSHSSCVRLWQCGEG 408 + V +GS + +R+W G Sbjct: 428 SLQFDGIH-------VVSGSLDTSIRVWDVETG 453 >gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo sapiens] Length = 707 Score = 98.6 bits (244), Expect = 1e-20 Identities = 62/218 (28%), Positives = 112/218 (51%), Gaps = 24/218 (11%) Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 198 I L GH ++ C+ + + + S ++D ++ W +E+G+ LHV+ GH Sbjct: 454 IHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQCLHVL-----------MGH 500 Query: 199 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYS 258 + V C + DG+ + SG ++ +W+ ++ L+T GH + V L F G H + S Sbjct: 501 VAAVRC--VQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF-DGIH-VVS 556 Query: 259 TSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL 318 S D S++VW+V + + TL GHQ + ++ ++ + +G D TV++W I L Sbjct: 557 GSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCL 614 Query: 319 -VFYG---HQGSIDCIHLINEEHMVSGADDGSVALWGL 352 G HQ ++ C+ N+ +++ +DDG+V LW L Sbjct: 615 QTLQGPNKHQSAVTCLQ-FNKNFVITSSDDGTVKLWDL 651 Score = 77.0 bits (188), Expect = 3e-14 Identities = 60/213 (28%), Positives = 88/213 (41%), Gaps = 20/213 (9%) Query: 197 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQL 256 GH HV+ + G + SG + +W A + + L T GH V R + Sbjct: 378 GHDDHVIT-CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNI--I 434 Query: 257 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEES 316 S S DR++KVWN + TL+GH V + E V +G RD T+RVW I Sbjct: 435 ISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQ 492 Query: 317 QL-VFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQ 375 L V GH ++ C+ + +VSGA D V +W + L H L+G Sbjct: 493 CLHVLMGHVAAVRCVQ-YDGRRVVSGAYDFMVKVWDPETETCL------HTLQGHTNRVY 545 Query: 376 PFWISSVAALLNTDLVATGSHSSCVRLWQCGEG 408 + V +GS + +R+W G Sbjct: 546 SLQFDGIH-------VVSGSLDTSIRVWDVETG 571 >gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo sapiens] Length = 627 Score = 98.6 bits (244), Expect = 1e-20 Identities = 62/218 (28%), Positives = 112/218 (51%), Gaps = 24/218 (11%) Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 198 I L GH ++ C+ + + + S ++D ++ W +E+G+ LHV+ GH Sbjct: 374 IHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQCLHVL-----------MGH 420 Query: 199 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYS 258 + V C + DG+ + SG ++ +W+ ++ L+T GH + V L F G H + S Sbjct: 421 VAAVRC--VQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF-DGIH-VVS 476 Query: 259 TSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL 318 S D S++VW+V + + TL GHQ + ++ ++ + +G D TV++W I L Sbjct: 477 GSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCL 534 Query: 319 -VFYG---HQGSIDCIHLINEEHMVSGADDGSVALWGL 352 G HQ ++ C+ N+ +++ +DDG+V LW L Sbjct: 535 QTLQGPNKHQSAVTCLQ-FNKNFVITSSDDGTVKLWDL 571 Score = 77.0 bits (188), Expect = 3e-14 Identities = 60/213 (28%), Positives = 88/213 (41%), Gaps = 20/213 (9%) Query: 197 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQL 256 GH HV+ + G + SG + +W A + + L T GH V R + Sbjct: 298 GHDDHVIT-CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNI--I 354 Query: 257 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEES 316 S S DR++KVWN + TL+GH V + E V +G RD T+RVW I Sbjct: 355 ISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQ 412 Query: 317 QL-VFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQ 375 L V GH ++ C+ + +VSGA D V +W + L H L+G Sbjct: 413 CLHVLMGHVAAVRCVQ-YDGRRVVSGAYDFMVKVWDPETETCL------HTLQGHTNRVY 465 Query: 376 PFWISSVAALLNTDLVATGSHSSCVRLWQCGEG 408 + V +GS + +R+W G Sbjct: 466 SLQFDGIH-------VVSGSLDTSIRVWDVETG 491 >gi|4502477 beta-transducin repeat containing protein isoform 2 [Homo sapiens] Length = 569 Score = 92.4 bits (228), Expect = 8e-19 Identities = 68/217 (31%), Positives = 104/217 (47%), Gaps = 24/217 (11%) Query: 140 RVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHS 199 R+L GH S+ CL D+ I + + D ++ W V +G L+ + H Sbjct: 301 RILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTGEMLNTLIH-----------HC 347 Query: 200 SHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLY---TFTGHRDAVSGLAFRRGTHQL 256 VL + ++ S DRS I +W+ S + GHR AV+ + F + Sbjct: 348 EAVLHLRFNNGMMVTCSKDRS--IAVWDMASPTDITLRRVLVGHRAAVNVVDF--DDKYI 403 Query: 257 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEES 316 S S DR++KVWN + +V TL GH+ +A L R+ V +G D T+R+W I + Sbjct: 404 VSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQ--YRDRLVVSGSSDNTIRLWDIECGA 461 Query: 317 QL-VFYGHQGSIDCIHLINEEHMVSGADDGSVALWGL 352 L V GH+ + CI N + +VSGA DG + +W L Sbjct: 462 CLRVLEGHEELVRCIRFDN-KRIVSGAYDGKIKVWDL 497 Score = 62.0 bits (149), Expect = 1e-09 Identities = 56/222 (25%), Positives = 100/222 (45%), Gaps = 28/222 (12%) Query: 199 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYS 258 S V C+ D + + SG R I IW+ + + TGH +V L + + + Sbjct: 267 SKGVYCLQY--DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSV--LCLQYDERVIIT 322 Query: 259 TSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL 318 S D +V+VW+V + TL H +AV L + VT +D ++ VW + + + Sbjct: 323 GSSDSTVRVWDVNTGEMLNTLIHHCEAVLHL-RFNNGMMVTC-SKDRSIAVWDMASPTDI 380 Query: 319 ----VFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLE 374 V GH+ +++ + +++++VS + D ++ +W S R +G + Sbjct: 381 TLRRVLVGHRAAVNVVD-FDDKYIVSASGDRTIKVWNTS---TCEFVRTLNGHK------ 430 Query: 375 QPFWISSVAALLNTD-LVATGSHSSCVRLW--QCGEGFRQLD 413 +A L D LV +GS + +RLW +CG R L+ Sbjct: 431 -----RGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLE 467 Score = 46.6 bits (109), Expect = 5e-05 Identities = 39/140 (27%), Positives = 56/140 (40%), Gaps = 26/140 (18%) Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 198 +R L GH+ I CL D + S + D +I W +E G L V+ GH Sbjct: 423 VRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLE-----------GH 469 Query: 199 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQH---------LYTFTGHRDAVSGLAF 249 V C I D K + SG I +W+ + L T H V L F Sbjct: 470 EELVRC--IRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQF 527 Query: 250 RRGTHQLYSTSHDRSVKVWN 269 Q+ S+SHD ++ +W+ Sbjct: 528 DE--FQIVSSSHDDTILIWD 545 >gi|16117783 beta-transducin repeat containing protein isoform 1 [Homo sapiens] Length = 605 Score = 92.4 bits (228), Expect = 8e-19 Identities = 68/217 (31%), Positives = 104/217 (47%), Gaps = 24/217 (11%) Query: 140 RVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHS 199 R+L GH S+ CL D+ I + + D ++ W V +G L+ + H Sbjct: 337 RILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTGEMLNTLIH-----------HC 383 Query: 200 SHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLY---TFTGHRDAVSGLAFRRGTHQL 256 VL + ++ S DRS I +W+ S + GHR AV+ + F + Sbjct: 384 EAVLHLRFNNGMMVTCSKDRS--IAVWDMASPTDITLRRVLVGHRAAVNVVDF--DDKYI 439 Query: 257 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEES 316 S S DR++KVWN + +V TL GH+ +A L R+ V +G D T+R+W I + Sbjct: 440 VSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQ--YRDRLVVSGSSDNTIRLWDIECGA 497 Query: 317 QL-VFYGHQGSIDCIHLINEEHMVSGADDGSVALWGL 352 L V GH+ + CI N + +VSGA DG + +W L Sbjct: 498 CLRVLEGHEELVRCIRFDN-KRIVSGAYDGKIKVWDL 533 Score = 62.0 bits (149), Expect = 1e-09 Identities = 56/222 (25%), Positives = 100/222 (45%), Gaps = 28/222 (12%) Query: 199 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYS 258 S V C+ D + + SG R I IW+ + + TGH +V L + + + Sbjct: 303 SKGVYCLQY--DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSV--LCLQYDERVIIT 358 Query: 259 TSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL 318 S D +V+VW+V + TL H +AV L + VT +D ++ VW + + + Sbjct: 359 GSSDSTVRVWDVNTGEMLNTLIHHCEAVLHL-RFNNGMMVTC-SKDRSIAVWDMASPTDI 416 Query: 319 ----VFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLE 374 V GH+ +++ + +++++VS + D ++ +W S R +G + Sbjct: 417 TLRRVLVGHRAAVNVVD-FDDKYIVSASGDRTIKVWNTS---TCEFVRTLNGHK------ 466 Query: 375 QPFWISSVAALLNTD-LVATGSHSSCVRLW--QCGEGFRQLD 413 +A L D LV +GS + +RLW +CG R L+ Sbjct: 467 -----RGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLE 503 Score = 46.6 bits (109), Expect = 5e-05 Identities = 39/140 (27%), Positives = 56/140 (40%), Gaps = 26/140 (18%) Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 198 +R L GH+ I CL D + S + D +I W +E G L V+ GH Sbjct: 459 VRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLE-----------GH 505 Query: 199 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQH---------LYTFTGHRDAVSGLAF 249 V C I D K + SG I +W+ + L T H V L F Sbjct: 506 EELVRC--IRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQF 563 Query: 250 RRGTHQLYSTSHDRSVKVWN 269 Q+ S+SHD ++ +W+ Sbjct: 564 DE--FQIVSSSHDDTILIWD 581 >gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit [Homo sapiens] Length = 410 Score = 88.6 bits (218), Expect = 1e-17 Identities = 98/407 (24%), Positives = 162/407 (39%), Gaps = 65/407 (15%) Query: 54 ESESLAPRKPEEEEEEELEETAQEKKLRLAKLYLEQLRQQEEEKAEARAFEEDQVAGRLK 113 E+ S+ ++ E + EEL++ L K + +R Q+ + E + K Sbjct: 26 EAYSVFKKEAELDVNEELDKKYAGL---LEKKWTSVIRLQK------KVMELESKLNEAK 76 Query: 114 EDVLEQRGRLQKLVAKEIQAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKW 173 E+ QK KE P + L GH+ +T ++ P S + SA++D +I W Sbjct: 77 EEFTSGGPLGQKRDPKE-WIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVW 135 Query: 174 SVESGRKLHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQH 233 E+G E GH+ V ++ GK LAS I +W+ Q + Sbjct: 136 DYETG-----------DFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFEC 184 Query: 234 LYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALS 293 + T GH VS +A + S S D+++K+W V V+T GH++ V + Sbjct: 185 IRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQ 244 Query: 294 RECCVTAGGRDGTVRVWKI-PEESQLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGL 352 + + D TVRVW + +E + H+ ++CI E S S A Sbjct: 245 DGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPE----SSYSSISEATGSE 300 Query: 353 SKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQL 412 +KK G+PG PF +S GS +++W G Sbjct: 301 TKK------------SGKPG---PFLLS-------------GSRDKTIKMWDVSTG---- 328 Query: 413 DLLCDIPLVG---FINSLKFSSSGDFLVAGVGQEHRLGRWWRIKEAR 456 +C + LVG ++ + F S G F+++ + + R W K R Sbjct: 329 --MCLMTLVGHDNWVRGVLFHSGGKFILSCA--DDKTLRVWDYKNKR 371 Score = 70.9 bits (172), Expect = 2e-12 Identities = 52/224 (23%), Positives = 91/224 (40%), Gaps = 51/224 (22%) Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESG-------------------- 178 IR + GH +++ + + P+ I SA++D +I W V++G Sbjct: 185 IRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQ 244 Query: 179 -----------RKLHVIPRAKKGAEGKPPGHSSHVLCMAISSD----------------- 210 + + V A K + + H V C++ + + Sbjct: 245 DGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKS 304 Query: 211 ---GKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKV 267 G +L SG R K I +W+ + L T GH + V G+ F G + S + D++++V Sbjct: 305 GKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRV 364 Query: 268 WNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWK 311 W+ ++TL H+ V +LD V G D TV+VW+ Sbjct: 365 WDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408 >gi|16554629 WD repeat domain 5 [Homo sapiens] Length = 334 Score = 85.9 bits (211), Expect = 7e-17 Identities = 56/222 (25%), Positives = 102/222 (45%), Gaps = 17/222 (7%) Query: 140 RVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHS 199 + + GH+L I+ + + D + + SA+ D ++ W V SG+ L + GHS Sbjct: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK-----------GHS 129 Query: 200 SHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYST 259 ++V C + + SG + + IW+ ++ + L T H D VS + F R + S+ Sbjct: 130 NYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSS 189 Query: 260 SHDRSVKVWNVAENSYVETLFGHQDAVAALDALS-RECCVTAGGRDGTVRVWKIPEESQL 318 S+D ++W+ A ++TL + + S + A D T+++W + L Sbjct: 190 SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL 249 Query: 319 VFY-GHQGSIDCI----HLINEEHMVSGADDGSVALWGLSKK 355 Y GH+ CI + + +VSG++D V +W L K Sbjct: 250 KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK 291 Score = 79.0 bits (193), Expect = 9e-15 Identities = 44/156 (28%), Positives = 79/156 (50%), Gaps = 2/156 (1%) Query: 197 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQL 256 GH+ V + S +G++LAS KLI IW A + T +GH+ +S +A+ ++ L Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102 Query: 257 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEES 316 S S D+++K+W+V+ ++TL GH + V + + + +G D +VR+W + Sbjct: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162 Query: 317 QL-VFYGHQGSIDCIHLINEEHM-VSGADDGSVALW 350 L H + +H + + VS + DG +W Sbjct: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198 Score = 68.9 bits (167), Expect = 9e-12 Identities = 53/220 (24%), Positives = 93/220 (42%), Gaps = 14/220 (6%) Query: 142 LRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSH 201 L GH +++ + +P+ + S++ D I W G+ E GH Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK-----------FEKTISGHKLG 89 Query: 202 VLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSH 261 + +A SSD L S K + IW+ S + L T GH + V F ++ + S S Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149 Query: 262 DRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL--V 319 D SV++W+V ++TL H D V+A+ + + DG R+W L + Sbjct: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209 Query: 320 FYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPL 358 + + N +++++ D ++ LW SK + L Sbjct: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL 249 Score = 68.6 bits (166), Expect = 1e-11 Identities = 51/207 (24%), Positives = 94/207 (45%), Gaps = 17/207 (8%) Query: 235 YTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSR 294 +T GH AVS + F L S+S D+ +K+W + + +T+ GH+ ++ + S Sbjct: 39 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98 Query: 295 ECCVTAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHLINEEHM-VSGADDGSVALWGL 352 + + D T+++W + L GH + C + + ++ VSG+ D SV +W + Sbjct: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158 Query: 353 SKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQL 412 + L+ P P +S+V + L+ + S+ R+W G Sbjct: 159 ---------KTGKCLKTLPAHSDP--VSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 207 Query: 413 DLL-CDIPLVGFINSLKFSSSGDFLVA 438 L+ D P V F+ KFS +G +++A Sbjct: 208 TLIDDDNPPVSFV---KFSPNGKYILA 231 Score = 63.5 bits (153), Expect = 4e-10 Identities = 49/220 (22%), Positives = 95/220 (43%), Gaps = 19/220 (8%) Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 198 ++ L+GH + C P + I S + D S+ W V++G+ L + P H Sbjct: 122 LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL-----------PAH 170 Query: 199 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYT-FTGHRDAVSGLAFRRGTHQLY 257 S V + + DG + S L IW+ S Q L T VS + F + Sbjct: 171 SDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYIL 230 Query: 258 STSHDRSVKVWNVAENSYVETLFGHQD---AVAALDALSRECCVTAGGRDGTVRVWKI-P 313 + + D ++K+W+ ++ ++T GH++ + A +++ + +G D V +W + Sbjct: 231 AATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 290 Query: 314 EESQLVFYGHQGSIDCIHLINEEHMVSGA---DDGSVALW 350 +E GH + E++++ A +D ++ LW Sbjct: 291 KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 >gi|16554627 WD repeat domain 5 [Homo sapiens] Length = 334 Score = 85.9 bits (211), Expect = 7e-17 Identities = 56/222 (25%), Positives = 102/222 (45%), Gaps = 17/222 (7%) Query: 140 RVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHS 199 + + GH+L I+ + + D + + SA+ D ++ W V SG+ L + GHS Sbjct: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK-----------GHS 129 Query: 200 SHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYST 259 ++V C + + SG + + IW+ ++ + L T H D VS + F R + S+ Sbjct: 130 NYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSS 189 Query: 260 SHDRSVKVWNVAENSYVETLFGHQDAVAALDALS-RECCVTAGGRDGTVRVWKIPEESQL 318 S+D ++W+ A ++TL + + S + A D T+++W + L Sbjct: 190 SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL 249 Query: 319 VFY-GHQGSIDCI----HLINEEHMVSGADDGSVALWGLSKK 355 Y GH+ CI + + +VSG++D V +W L K Sbjct: 250 KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK 291 Score = 79.0 bits (193), Expect = 9e-15 Identities = 44/156 (28%), Positives = 79/156 (50%), Gaps = 2/156 (1%) Query: 197 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQL 256 GH+ V + S +G++LAS KLI IW A + T +GH+ +S +A+ ++ L Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102 Query: 257 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEES 316 S S D+++K+W+V+ ++TL GH + V + + + +G D +VR+W + Sbjct: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162 Query: 317 QL-VFYGHQGSIDCIHLINEEHM-VSGADDGSVALW 350 L H + +H + + VS + DG +W Sbjct: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198 Score = 68.9 bits (167), Expect = 9e-12 Identities = 53/220 (24%), Positives = 93/220 (42%), Gaps = 14/220 (6%) Query: 142 LRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSH 201 L GH +++ + +P+ + S++ D I W G+ E GH Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK-----------FEKTISGHKLG 89 Query: 202 VLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSH 261 + +A SSD L S K + IW+ S + L T GH + V F ++ + S S Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149 Query: 262 DRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL--V 319 D SV++W+V ++TL H D V+A+ + + DG R+W L + Sbjct: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209 Query: 320 FYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPL 358 + + N +++++ D ++ LW SK + L Sbjct: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL 249 Score = 68.6 bits (166), Expect = 1e-11 Identities = 51/207 (24%), Positives = 94/207 (45%), Gaps = 17/207 (8%) Query: 235 YTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSR 294 +T GH AVS + F L S+S D+ +K+W + + +T+ GH+ ++ + S Sbjct: 39 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98 Query: 295 ECCVTAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHLINEEHM-VSGADDGSVALWGL 352 + + D T+++W + L GH + C + + ++ VSG+ D SV +W + Sbjct: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158 Query: 353 SKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQL 412 + L+ P P +S+V + L+ + S+ R+W G Sbjct: 159 ---------KTGKCLKTLPAHSDP--VSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 207 Query: 413 DLL-CDIPLVGFINSLKFSSSGDFLVA 438 L+ D P V F+ KFS +G +++A Sbjct: 208 TLIDDDNPPVSFV---KFSPNGKYILA 231 Score = 63.5 bits (153), Expect = 4e-10 Identities = 49/220 (22%), Positives = 95/220 (43%), Gaps = 19/220 (8%) Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 198 ++ L+GH + C P + I S + D S+ W V++G+ L + P H Sbjct: 122 LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL-----------PAH 170 Query: 199 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYT-FTGHRDAVSGLAFRRGTHQLY 257 S V + + DG + S L IW+ S Q L T VS + F + Sbjct: 171 SDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYIL 230 Query: 258 STSHDRSVKVWNVAENSYVETLFGHQD---AVAALDALSRECCVTAGGRDGTVRVWKI-P 313 + + D ++K+W+ ++ ++T GH++ + A +++ + +G D V +W + Sbjct: 231 AATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 290 Query: 314 EESQLVFYGHQGSIDCIHLINEEHMVSGA---DDGSVALW 350 +E GH + E++++ A +D ++ LW Sbjct: 291 KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 >gi|157266266 WD repeat domain 86 [Homo sapiens] Length = 376 Score = 85.1 bits (209), Expect = 1e-16 Identities = 67/225 (29%), Positives = 103/225 (45%), Gaps = 31/225 (13%) Query: 141 VLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSS 200 +L+GH+ +T + +D A F+ + DC+I +W V +G+ L V GH+S Sbjct: 52 LLQGHESYVTFCQL--EDEAAFTCSADCTIRRWDVLTGQCLQVY-----------RGHTS 98 Query: 201 HVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAF----------- 249 V + ++++ + +S DR+ +W Q F GHR+ V LA+ Sbjct: 99 IVNRILVANNQLFSSSYDRT--ARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPC 156 Query: 250 ---RRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGT 306 L + S D + KVW VA +TL GH AV L + G D T Sbjct: 157 AEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDAT 216 Query: 307 VRVWKIPEESQL-VFYGHQGSIDCIHLINEEHMVSGADDGSVALW 350 +R W I QL VF H+GS+ C+ L+N + SG+ D +V W Sbjct: 217 IRAWDILSGEQLRVFREHRGSVICLELVN-RLVYSGSADRTVKCW 260 Score = 82.4 bits (202), Expect = 8e-16 Identities = 68/286 (23%), Positives = 116/286 (40%), Gaps = 44/286 (15%) Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 198 +RV H+ I L ++PD + + ++D + WS G+ ++ GH Sbjct: 8 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALL-----------QGH 56 Query: 199 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYS 258 S+V + + + S D + I W+ + Q L + GH V+ + +QL+S Sbjct: 57 ESYVTFCQLEDEAAFTCSADCT--IRRWDVLTGQCLQVYRGHTSIVNRILV--ANNQLFS 112 Query: 259 TSHDRSVKVWNVAENSYVETLFGHQDAVAAL------DALSRECC--------VTAGGRD 304 +S+DR+ +VW+V + GH++ V L D S C + G D Sbjct: 113 SSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTD 172 Query: 305 GTVRVWKIPEE-SQLVFYGHQGSIDCIHLINEEHMV-SGADDGSVALWGLSKKRPLALQR 362 GT +VW++ GH G++ C+ L H +G+ D ++ W + L + R Sbjct: 173 GTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFR 232 Query: 363 EAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEG 408 E G S + L LV +GS V+ W G Sbjct: 233 EHRG-------------SVICLELVNRLVYSGSADRTVKCWLADTG 265 Score = 65.9 bits (159), Expect = 8e-11 Identities = 46/185 (24%), Positives = 78/185 (42%), Gaps = 17/185 (9%) Query: 128 AKEIQAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRA 187 AK Q + + LRGH ++ CLV+ F+ + D +I W + SG +L V Sbjct: 175 AKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFRE- 233 Query: 188 KKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGL 247 H V+C+ + + Y S DR+ + W A + + + TFT HR VS L Sbjct: 234 ----------HRGSVICLELVNRLVYSGSADRT--VKCWLADTGECVRTFTAHRRNVSAL 281 Query: 248 AFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTV 307 + GT L++ S D + ++ GH + + + + DG + Sbjct: 282 KYHAGT--LFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQ--VLYTASHDGAL 337 Query: 308 RVWKI 312 R+W + Sbjct: 338 RLWDV 342 Score = 57.0 bits (136), Expect = 4e-08 Identities = 60/282 (21%), Positives = 106/282 (37%), Gaps = 71/282 (25%) Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEG----- 193 ++V RGH + ++V ++ +FS++ D + WSV+ G+ + R +G Sbjct: 90 LQVYRGHTSIVNRILVA--NNQLFSSSYDRTARVWSVDKGQ----MSREFRGHRNCVLTL 143 Query: 194 --KPPGHSSHVLCMAISSDGKYLASGDRSKLILIWE-AQSCQHLYTFTGHRDAVSGLAFR 250 P C ++ G L +G +W+ A C H T GH AV L Sbjct: 144 AYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCH-QTLRGHTGAVLCLVLD 202 Query: 251 RGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVW 310 H ++ S D +++ W++ + H+ +V L+ ++R V +G D TV+ W Sbjct: 203 TPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNR--LVYSGSADRTVKCW 260 Query: 311 KIPE-----------------------------------------ESQLVFYGHQGSIDC 329 E + VF GH I+C Sbjct: 261 LADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINC 320 Query: 330 IHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEP 371 I ++ + + + + DG++ LW + GLRG P Sbjct: 321 IQ-VHGQVLYTASHDGALRLW------------DVRGLRGAP 349 >gi|21071067 TBP-associated factor 5 [Homo sapiens] Length = 800 Score = 84.0 bits (206), Expect = 3e-16 Identities = 101/438 (23%), Positives = 162/438 (36%), Gaps = 46/438 (10%) Query: 10 RGKPASGAGAGAGAGKRRRKADSAGDRGKSKGGGKMNEEISSDSESESLAPRKPEEEEEE 69 R K A G+ AG+ +R+A+ + K+ + + E E P E+EE E Sbjct: 347 RSKQQIDAMVGSLAGEAKREANKS----------KVFFGLLKEPEIE--VPLDDEDEEGE 394 Query: 70 ELEETAQEKKLRLAKLYLEQLRQQEEEKAEARAFEEDQVAGRLKEDVLEQRGRLQKLVAK 129 E ++KK + + + +Q + R + + ++ + +++ Sbjct: 395 NEEGKPKKKKPKKDSIGSKSKKQDPNAPPQNRIPLPELKDSDKLDKIMNMKETTKRVRLG 454 Query: 130 EIQAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSV-------------- 175 P+ L +Q +T + VT D S I D ++ WSV Sbjct: 455 PDCLPSICFYTFLNAYQ-GLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDL 513 Query: 176 -----ESGRKLHVIPRAKKGAEGKPP-GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQ 229 ES L I K +E K GHS V + S D YL S + +W Q Sbjct: 514 SLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQ 573 Query: 230 SCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAAL 289 + L + GH V F + S HDR ++W + GH V Sbjct: 574 TFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCT 633 Query: 290 DALSRECCVTAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHLI-NEEHMVSGADDGSV 347 V G D TVR+W + + + +F GH+G I + N + +GA DG V Sbjct: 634 RFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRV 693 Query: 348 ALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGE 407 LW + HGL + S+ + +++A+GS + VRLW + Sbjct: 694 LLWDIG-----------HGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIK 742 Query: 408 GFRQLDLLCDIPLVGFIN 425 F L+ G IN Sbjct: 743 AFEDLETDDFTTATGHIN 760 >gi|23199987 WD repeat domain 5B [Homo sapiens] Length = 330 Score = 82.4 bits (202), Expect = 8e-16 Identities = 57/222 (25%), Positives = 98/222 (44%), Gaps = 17/222 (7%) Query: 140 RVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHS 199 + L GH L I+ + + D S + SA+ D ++ W V SG+ L + GHS Sbjct: 77 KTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLK-----------GHS 125 Query: 200 SHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYST 259 ++V C + + SG + + IWE ++ + L T + H D VS + F + S Sbjct: 126 NYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSG 185 Query: 260 SHDRSVKVWNVAENSYVETLFGHQDAVAALDALS-RECCVTAGGRDGTVRVWKIPEESQL 318 S+D ++W+ A ++TL + + S + D T+++W L Sbjct: 186 SYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCL 245 Query: 319 VFY-GHQGSIDCI----HLINEEHMVSGADDGSVALWGLSKK 355 Y GH+ CI + + +VSG++D V +W L K Sbjct: 246 KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK 287 Score = 78.6 bits (192), Expect = 1e-14 Identities = 44/156 (28%), Positives = 79/156 (50%), Gaps = 2/156 (1%) Query: 197 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQL 256 GH+ V + S +G++LAS +LI+IW A ++ T GH +S +A+ + +L Sbjct: 39 GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRL 98 Query: 257 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEES 316 S S D+++K+W+V ++TL GH + V + + +G D TV++W++ Sbjct: 99 VSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGK 158 Query: 317 QL-VFYGHQGSIDCIHL-INEEHMVSGADDGSVALW 350 L H + +H + +VSG+ DG +W Sbjct: 159 CLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194 Score = 72.8 bits (177), Expect = 6e-13 Identities = 46/169 (27%), Positives = 77/169 (45%), Gaps = 11/169 (6%) Query: 142 LRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSH 201 L GH +++ + +P+ + S++ D II W G+ E GH+ Sbjct: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGK-----------YEKTLYGHNLE 85 Query: 202 VLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSH 261 + +A SSD L S K + +W+ +S + L T GH + V F ++ + S S Sbjct: 86 ISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSF 145 Query: 262 DRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVW 310 D +VK+W V ++TL H D V+A+ + +G DG R+W Sbjct: 146 DETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194 Score = 65.9 bits (159), Expect = 8e-11 Identities = 50/205 (24%), Positives = 92/205 (44%), Gaps = 17/205 (8%) Query: 236 TFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRE 295 T GH +AVS + F L S+S DR + +W + Y +TL+GH ++ + S Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95 Query: 296 CCVTAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHLINEEHM-VSGADDGSVALWGLS 353 + + D T+++W + L GH + C + ++ +SG+ D +V +W + Sbjct: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVK 155 Query: 354 KKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLD 413 + L + +P +S+V + L+ +GS+ R+W G Sbjct: 156 TGKCL----KTLSAHSDP-------VSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKT 204 Query: 414 LL-CDIPLVGFINSLKFSSSGDFLV 437 L+ D P V F+ KFS +G +++ Sbjct: 205 LVDDDNPPVSFV---KFSPNGKYIL 226 Score = 60.8 bits (146), Expect = 3e-09 Identities = 48/220 (21%), Positives = 94/220 (42%), Gaps = 19/220 (8%) Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 198 ++ L+GH + C P + I S + D ++ W V++G+ L + H Sbjct: 118 LKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTL-----------SAH 166 Query: 199 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFT-GHRDAVSGLAFRRGTHQLY 257 S V + + G + SG L IW+A S Q L T VS + F + Sbjct: 167 SDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYIL 226 Query: 258 STSHDRSVKVWNVAENSYVETLFGHQD---AVAALDALSRECCVTAGGRDGTVRVWKI-P 313 + + D ++K+W+ + ++T GH++ + A +++ + +G D V +W + Sbjct: 227 TATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 286 Query: 314 EESQLVFYGHQGSIDCIHLINEEHMVSGA---DDGSVALW 350 +E GH + E++++ A +D ++ LW Sbjct: 287 KEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326 >gi|21536371 telomerase-associated protein 1 [Homo sapiens] Length = 2627 Score = 81.6 bits (200), Expect = 1e-15 Identities = 83/305 (27%), Positives = 133/305 (43%), Gaps = 34/305 (11%) Query: 163 SAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKL 222 SA++D ++ W + + H G E + GH V C + S+DG LA+G R + Sbjct: 2027 SASEDFTVQLWPRQLLTRPHKAEDFPCGTELR--GHEGPVSCCSFSTDGGSLATGGRDRS 2084 Query: 223 ILIWEAQSCQH---LYTFTG-HRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVET 278 +L W+ ++ + +++F HRD V+G A+ + + L S S D SV +W+ + Sbjct: 2085 LLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTK-DNLLISCSSDGSVGLWDPESGQRLGQ 2143 Query: 279 LFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYGHQGSID-CIHLI---- 333 GHQ AV+A+ A+ V + RDGT++VW H G I C + Sbjct: 2144 FLGHQSAVSAVAAVEEH--VVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCAAAMEPRA 2201 Query: 334 -----NEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNT 388 +E +V+ DG+ LW PL L + H L G G + + A + Sbjct: 2202 AGQPGSELLVVTVGLDGATRLW-----HPL-LVCQTHTLLGHSGP-----VRAAAVSETS 2250 Query: 389 DLVATGSHSSCVRLWQCGEGFRQLDLLCDIPLVGFINSLKFSSSGDFLVAGVGQEHRLGR 448 L+ T S VRLWQ ++ D C + ++ ++ G V+G Q L Sbjct: 2251 GLMLTASEDGSVRLWQVP---KEADDTCIPRSSAAVTAVAWAPDGSMAVSG-NQAGELIL 2306 Query: 449 WWRIK 453 W K Sbjct: 2307 WQEAK 2311 Score = 65.9 bits (159), Expect = 8e-11 Identities = 72/321 (22%), Positives = 132/321 (41%), Gaps = 45/321 (14%) Query: 142 LRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSH 201 LRGH+ ++C + D ++ + +D S++ W V + P+ P H Sbjct: 2057 LRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRT-------PKTPVLIHSFPACHRDW 2109 Query: 202 VLCMAISSDGKYLA-SGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTS 260 V A + D ++ S D S + +W+ +S Q L F GH+ AVS +A + S S Sbjct: 2110 VTGCAWTKDNLLISCSSDGS--VGLWDPESGQRLGQFLGHQSAVSAVA--AVEEHVVSVS 2165 Query: 261 HDRSVKVWNVAENSYVETLFGHQDAVA---------ALDALSRECCVTAGGRDGTVRVWK 311 D ++KVW+ + + ++ H ++ A E V G DG R+W Sbjct: 2166 RDGTLKVWD-HQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWH 2224 Query: 312 IPEESQL-VFYGHQGSIDCIHLINEEH-MVSGADDGSVALWGLSKKR-PLALQREAHGLR 368 Q GH G + + M++ ++DGSV LW + K+ + R + Sbjct: 2225 PLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAA-- 2282 Query: 369 GEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPLVGFINSLK 428 +++VA + + +G+ + + LWQ + + G I +L Sbjct: 2283 ----------VTAVAWAPDGSMAVSGNQAGELILWQ------EAKAVATAQAPGHIGALI 2326 Query: 429 FSSSGDFLVAGVGQEHRLGRW 449 +SS+ F V + + ++ W Sbjct: 2327 WSSAHTFFV--LSADEKISEW 2345 Score = 44.3 bits (103), Expect = 2e-04 Identities = 80/362 (22%), Positives = 139/362 (38%), Gaps = 36/362 (9%) Query: 85 LYLEQLRQQEEEKAEARAFEEDQVAGRLKEDVLEQRGRLQKLVAKEIQAPASADIRVL-- 142 +YL LR +EEK+ + L +D L L ++Q RVL Sbjct: 1700 VYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTAFDGLLELWDLQHGC----RVLQT 1755 Query: 143 RGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKL--HVIPRAKKGAEGKPPGHSS 200 + HQ IT ++PD + + + W G+ H P++ Sbjct: 1756 KAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYPKSLN----------- 1804 Query: 201 HVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTS 260 C+A +G+ +A+G + I ++ + ++ LAF + Sbjct: 1805 ---CVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGR 1861 Query: 261 HDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVF 320 D V++W E + + H VAA L C + G DG V+VW S Sbjct: 1862 LDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVW---SGSLGRP 1918 Query: 321 YGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWIS 380 GH GS+ ++ V+ + DG G + + + + + G +G G +S Sbjct: 1919 RGHLGSLS----LSPALSVALSPDGDRVAVGY-RADGIRIYKISSGSQGAQGQALDVAVS 1973 Query: 381 SVAALLNTDLVATGSHSSCVRLWQCGE-GFRQLDLLCDI--PLVGFINS--LKFSSSGDF 435 ++ A L+ ++ +G+ ++ W E + L LL P++G S L S+S DF Sbjct: 1974 AL-AWLSPKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDF 2032 Query: 436 LV 437 V Sbjct: 2033 TV 2034 >gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] Length = 589 Score = 80.9 bits (198), Expect = 2e-15 Identities = 55/209 (26%), Positives = 85/209 (40%), Gaps = 31/209 (14%) Query: 135 ASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRK-------------L 181 A ++++LRGH + D S + S ++D SI W + S L Sbjct: 331 AGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDL 390 Query: 182 HVIPRAKKGAEGKP------------------PGHSSHVLCMAISSDGKYLASGDRSKLI 223 + P + A G GH + V C+ + YLA+G K + Sbjct: 391 DISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTV 450 Query: 224 LIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQ 283 +W AQ + FTGHR V LAF L S D+ +K+W++A + + L GH Sbjct: 451 RLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHT 510 Query: 284 DAVAALDALSRECCVTAGGRDGTVRVWKI 312 D + +L + + D +VRVW I Sbjct: 511 DNITSLTFSPDSGLIASASMDNSVRVWDI 539 Score = 68.6 bits (166), Expect = 1e-11 Identities = 37/137 (27%), Positives = 65/137 (47%), Gaps = 12/137 (8%) Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 198 +R+ GH + C+ P+ + + + + D ++ WS + G + + GH Sbjct: 419 LRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLF-----------TGH 467 Query: 199 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYS 258 VL +A S +GKYLAS + + +W+ S GH D ++ L F + + S Sbjct: 468 RGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIAS 527 Query: 259 TSHDRSVKVWNVAENSY 275 S D SV+VW++ N+Y Sbjct: 528 ASMDNSVRVWDI-RNTY 543 Score = 60.8 bits (146), Expect = 3e-09 Identities = 62/265 (23%), Positives = 103/265 (38%), Gaps = 33/265 (12%) Query: 197 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQL 256 GH V +D L S I W+ S + + GH V L + Sbjct: 340 GHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYF 399 Query: 257 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPE-E 315 S SHDR+ ++W+ + GH V + + G D TVR+W + Sbjct: 400 ASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGN 459 Query: 316 SQLVFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLE 374 S +F GH+G + + N +++ S +D + LW L+ L +E G Sbjct: 460 SVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASG---TLYKELRGHTDN---- 512 Query: 375 QPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIP-------LVGF---- 423 I+S+ ++ L+A+ S + VR+W + C P LVG Sbjct: 513 ----ITSLTFSPDSGLIASASMDNSVRVWDIRNTY------CSAPADGSSSELVGVYTGQ 562 Query: 424 ---INSLKFSSSGDFLVAGVGQEHR 445 + S++F + LV G+ QE++ Sbjct: 563 MSNVLSVQFMACNLLLVTGITQENQ 587 Score = 33.1 bits (74), Expect = 0.57 Identities = 22/76 (28%), Positives = 33/76 (43%) Query: 142 LRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSH 201 LRGH +IT L +PD I SA+ D S+ W + + + G G S+ Sbjct: 506 LRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSN 565 Query: 202 VLCMAISSDGKYLASG 217 VL + + L +G Sbjct: 566 VLSVQFMACNLLLVTG 581 >gi|5174447 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 [Homo sapiens] Length = 317 Score = 80.1 bits (196), Expect = 4e-15 Identities = 62/224 (27%), Positives = 103/224 (45%), Gaps = 14/224 (6%) Query: 142 LRGHQLSITCLVVTPD-DSAIFSAAKDCSIIKWSVESGRKLHVIP-RAKKGAEGKPPGHS 199 L+GH +T + TP I SA++D +II W + + IP RA +G HS Sbjct: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG-------HS 63 Query: 200 SHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYST 259 V + ISSDG++ SG + +W+ + F GH V +AF Q+ S Sbjct: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123 Query: 260 SHDRSVKVWN-VAENSYVETLFGHQDAVAAL--DALSRECCVTAGGRDGTVRVWKIPE-E 315 S D+++K+WN + Y H + V+ + S + + G D V+VW + + Sbjct: 124 SRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK 183 Query: 316 SQLVFYGHQGSIDCIHLINEEHM-VSGADDGSVALWGLSKKRPL 358 + GH G ++ + + + + SG DG LW L++ + L Sbjct: 184 LKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHL 227 Score = 79.3 bits (194), Expect = 7e-15 Identities = 63/274 (22%), Positives = 109/274 (39%), Gaps = 16/274 (5%) Query: 140 RVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHS 199 R LRGH ++ +V++ D S + D ++ W + +G + GH+ Sbjct: 57 RALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTR-----------RFVGHT 105 Query: 200 SHVLCMAISSDGKYLASGDRSKLILIWEAQS-CQHLYTFTGHRDAVSGLAFRRGTHQ--L 256 VL +A SSD + + SG R K I +W C++ H + VS + F + + Sbjct: 106 KDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPII 165 Query: 257 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEES 316 S D+ VKVWN+A GH + + +GG+DG +W + E Sbjct: 166 VSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK 225 Query: 317 QLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQP 376 L I+ + + + A S+ +W L K + + + +P Sbjct: 226 HLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGK--IIVDELKQEVISTSSKAEP 283 Query: 377 FWISSVAALLNTDLVATGSHSSCVRLWQCGEGFR 410 +S+A + + G + VR+WQ G R Sbjct: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 >gi|26665869 WD repeat domain 51B [Homo sapiens] Length = 478 Score = 80.1 bits (196), Expect = 4e-15 Identities = 59/263 (22%), Positives = 115/263 (43%), Gaps = 24/263 (9%) Query: 144 GHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVL 203 GH+ +T + +P + + SA++D ++ W + K+G + H++ V Sbjct: 58 GHKDVVTSVQFSPHGNLLASASRDRTVRLWIPD-----------KRGKFSEFKAHTAPVR 106 Query: 204 CMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDR 263 + S+DG++LA+ K I +W + LY+ H V F + S S D+ Sbjct: 107 SVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDK 166 Query: 264 SVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYG- 322 ++K+W+ V +D C+ + G D TV+VW + L Y Sbjct: 167 TIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQV 226 Query: 323 HQGSIDCIHL-INEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISS 381 H G ++CI + ++++ + DG++ + L + R + + L+G G + + Sbjct: 227 HSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLI------YTLQGHTGP-----VFT 275 Query: 382 VAALLNTDLVATGSHSSCVRLWQ 404 V+ +L A+G + V LW+ Sbjct: 276 VSFSKGGELFASGGADTQVLLWR 298 Score = 64.7 bits (156), Expect = 2e-10 Identities = 36/162 (22%), Positives = 74/162 (45%), Gaps = 2/162 (1%) Query: 197 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQL 256 GH + + + +S +GK LA+ +++W + Y + GH+D V+ + F + L Sbjct: 16 GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75 Query: 257 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEES 316 S S DR+V++W + H V ++D + + D +++VW + + Sbjct: 76 ASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQR 135 Query: 317 QLV-FYGHQGSIDCIHLINEEHM-VSGADDGSVALWGLSKKR 356 L Y H + C + + VS ++D ++ +W + K+ Sbjct: 136 FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQ 177 Score = 61.2 bits (147), Expect = 2e-09 Identities = 50/222 (22%), Positives = 92/222 (41%), Gaps = 31/222 (13%) Query: 237 FTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSREC 296 F GH+ A++ L QL + S D + +WN ++ GH+D V ++ Sbjct: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73 Query: 297 CVTAGGRDGTVRVWKIPEESQLV--FYGHQGSIDCIHL-INEEHMVSGADDGSVALWGLS 353 + + RD TVR+W IP++ F H + + + + + + ++D S+ +W + Sbjct: 74 LLASASRDRTVRLW-IPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMY 132 Query: 354 KKRPL-ALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLW-----QCGE 407 ++R L +L R H W+ + L+ + S +++W QC Sbjct: 133 RQRFLYSLYRHTH------------WVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN 180 Query: 408 GFRQLDLLCDIPLVGFINSLKFSSSGDFLVAGVGQEHRLGRW 449 F VGF N + F+ SG +A G + + W Sbjct: 181 NFSD--------SVGFANFVDFNPSGT-CIASAGSDQTVKVW 213 >gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [Homo sapiens] Length = 340 Score = 79.3 bits (194), Expect = 7e-15 Identities = 85/362 (23%), Positives = 142/362 (39%), Gaps = 71/362 (19%) Query: 87 LEQLRQQEEEKA----EARAFEEDQVAGRLKEDVLEQRGRLQKLVAKEIQAPASADIRVL 142 L+QLRQ+ E+ +AR D ++ ++ + GR+Q R L Sbjct: 4 LDQLRQEAEQLKNQIRDARKACADATLSQITNNI-DPVGRIQMRTR-----------RTL 51 Query: 143 RGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAK-------------- 188 RGH I + D + SA++D +I W + K+H IP Sbjct: 52 RGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNY 111 Query: 189 ---------------KGAEGKP------PGHSSHVLCMAISSDGKYL-ASGDRSKLILIW 226 K EG GH+ ++ C D + + +SGD + +W Sbjct: 112 VACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTT--CALW 169 Query: 227 EAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAV 286 + ++ Q TFTGH V L+ T S + D S K+W+V E +T GH+ + Sbjct: 170 DIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDI 229 Query: 287 AALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYGHQGSIDCIHLINEEH----MVSGA 342 A+ G D T R++ + + +L+ Y H I I ++ +++G Sbjct: 230 NAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGY 289 Query: 343 DDGSVALWGLSKKRPLALQREAHG-LRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVR 401 DD + +W AL+ + G L G +S + + VATGS S ++ Sbjct: 290 DDFNCNVWD-------ALKADRAGVLAGHDNR-----VSCLGVTDDGMAVATGSWDSFLK 337 Query: 402 LW 403 +W Sbjct: 338 IW 339 Score = 31.6 bits (70), Expect = 1.6 Identities = 24/130 (18%), Positives = 50/130 (38%), Gaps = 17/130 (13%) Query: 144 GHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVL 203 GH+ I + P+ +A + + D + + + + ++L +++ Sbjct: 224 GHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSH-------------DNII 270 Query: 204 C----MAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYST 259 C ++ S G+ L +G +W+A GH + VS L + + Sbjct: 271 CGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATG 330 Query: 260 SHDRSVKVWN 269 S D +K+WN Sbjct: 331 SWDSFLKIWN 340 >gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [Homo sapiens] Length = 340 Score = 79.3 bits (194), Expect = 7e-15 Identities = 84/361 (23%), Positives = 142/361 (39%), Gaps = 69/361 (19%) Query: 87 LEQLRQQEEEKA----EARAFEEDQVAGRLKEDVLEQRGRLQKLVAKEIQAPASADIRVL 142 LEQLRQ+ E+ +AR D ++ L+ GR+Q R L Sbjct: 4 LEQLRQEAEQLRNQIRDARKACGDSTLTQITAG-LDPVGRIQMRTR-----------RTL 51 Query: 143 RGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIP----------------- 185 RGH I + D + SA++D +I W + K+H IP Sbjct: 52 RGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNF 111 Query: 186 ------------RAKKGAEG------KPPGHSSHVLCMAISSDGKYL-ASGDRSKLILIW 226 + K EG + PGH+ ++ C D + + +SGD + +W Sbjct: 112 VACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTT--CALW 169 Query: 227 EAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAV 286 + ++ Q F GH V L+ S + D S+K+W+V ++ +T GH+ + Sbjct: 170 DIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDI 229 Query: 287 AALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYGHQGSIDCIHLI----NEEHMVSGA 342 A+ T G D T R++ + + +L+ Y H I I + + +++G Sbjct: 230 NAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGY 289 Query: 343 DDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRL 402 DD + +W + K A H R +S + + VATGS S +++ Sbjct: 290 DDFNCNIWD-AMKGDRAGVLAGHDNR----------VSCLGVTDDGMAVATGSWDSFLKI 338 Query: 403 W 403 W Sbjct: 339 W 339 Score = 31.2 bits (69), Expect = 2.1 Identities = 26/130 (20%), Positives = 50/130 (38%), Gaps = 17/130 (13%) Query: 144 GHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVL 203 GH+ I + P+ A + + D + + + + ++L + +++ Sbjct: 224 GHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSH-------------DNII 270 Query: 204 C----MAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYST 259 C +A S G+ L +G IW+A GH + VS L + + Sbjct: 271 CGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATG 330 Query: 260 SHDRSVKVWN 269 S D +K+WN Sbjct: 331 SWDSFLKIWN 340 >gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] Length = 357 Score = 79.0 bits (193), Expect = 9e-15 Identities = 58/226 (25%), Positives = 106/226 (46%), Gaps = 17/226 (7%) Query: 137 ADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPP 196 A I +L GH+ + C P+ S + SA D I+ W+V + + Sbjct: 57 APIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLK---------- 106 Query: 197 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAV-SGLAFRRGTHQ 255 GHS V+ + ++DG L S K + +W++++ + + GH V S RRG Sbjct: 107 GHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQL 166 Query: 256 LYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEE 315 + + S D +VK+W++ + + ++T F + V A+ + +GG D ++VW + + Sbjct: 167 VCTGSDDGTVKLWDIRKKAAIQT-FQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQN 225 Query: 316 S-QLVFYGHQGSIDCIHLINE-EHMVSGADDGSVALWGLSKKRPLA 359 GH S+ + L +E +++S A D +V +W + RP A Sbjct: 226 KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDV---RPFA 268 Score = 73.6 bits (179), Expect = 4e-13 Identities = 55/228 (24%), Positives = 99/228 (43%), Gaps = 23/228 (10%) Query: 142 LRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSH 201 L+GH ++ L D S +FSA+ D ++ W E+G + + R K GH+S Sbjct: 105 LKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGER---VKRLK--------GHTSF 153 Query: 202 V-LCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTS 260 V C + + +G + +W+ + + TF ++ + F + Q+ S Sbjct: 154 VNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLA-VTFNDTSDQIISGG 212 Query: 261 HDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKI-----PEE 315 D +KVW++ +N T+ GH D+V L S + + D TVRVW + E Sbjct: 213 IDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKER 272 Query: 316 SQLVFYGH-----QGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPL 358 +F G+ + + C + + +G+ D V +W + +R L Sbjct: 273 CVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRIL 320 Score = 53.5 bits (127), Expect = 4e-07 Identities = 33/122 (27%), Positives = 58/122 (47%), Gaps = 3/122 (2%) Query: 142 LRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSH 201 +RGH S+T L ++ + S + S A D ++ W V R R K +G + Sbjct: 231 MRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDV---RPFAPKERCVKIFQGNVHNFEKN 287 Query: 202 VLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSH 261 +L + S DG +A+G + + +W+ S + LY GH +++ +AF + S S Sbjct: 288 LLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASS 347 Query: 262 DR 263 D+ Sbjct: 348 DK 349 Score = 35.0 bits (79), Expect = 0.15 Identities = 35/162 (21%), Positives = 66/162 (40%), Gaps = 24/162 (14%) Query: 138 DIR---VLRGHQLSITCLVVTPDDSA--IFSAAKDCSIIKWSVESGRKLHVIPRAKKGAE 192 DIR ++ Q + L VT +D++ I S D I W + + + + Sbjct: 180 DIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMR------- 232 Query: 193 GKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEA------QSCQHLYTFTGHRDAVSG 246 GH+ V +++SS+G YL S + +W+ + C ++ H + Sbjct: 233 ----GHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNL 288 Query: 247 L--AFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAV 286 L ++ ++ + S DR V VW+ + L GH ++ Sbjct: 289 LRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSI 330 Score = 30.8 bits (68), Expect = 2.8 Identities = 30/128 (23%), Positives = 48/128 (37%), Gaps = 13/128 (10%) Query: 279 LFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEE--SQLVFYGHQGSIDCIHLINEE 336 L GH+ V + + G D + +W + + + GH G++ +H + Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121 Query: 337 HMV-SGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGS 395 M+ S + D +VA+W L+G F S A LV TGS Sbjct: 122 SMLFSASTDKTVAVWDSETGE------RVKRLKGHTS----FVNSCYPARRGPQLVCTGS 171 Query: 396 HSSCVRLW 403 V+LW Sbjct: 172 DDGTVKLW 179 >gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [Homo sapiens] Length = 340 Score = 77.8 bits (190), Expect = 2e-14 Identities = 83/361 (22%), Positives = 140/361 (38%), Gaps = 69/361 (19%) Query: 87 LEQLRQQEEEKA----EARAFEEDQVAGRLKEDVLEQRGRLQKLVAKEIQAPASADIRVL 142 LEQLRQ+ E+ +AR D ++ + ++ GR+Q R L Sbjct: 4 LEQLRQEAEQLRNQIQDARKACNDATLVQITSN-MDSVGRIQMRTR-----------RTL 51 Query: 143 RGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAK-------------- 188 RGH I + D + SA++D +I W + K+H IP Sbjct: 52 RGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNY 111 Query: 189 ---------------KGAEG------KPPGHSSHVLCMAISSDGKYL-ASGDRSKLILIW 226 K EG + PGH+ ++ C D + + +SGD + +W Sbjct: 112 VACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTT--CALW 169 Query: 227 EAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAV 286 + ++ Q TFTGH V L+ S + D S K+W++ + ++ GH + Sbjct: 170 DIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDI 229 Query: 287 AALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYGHQGSIDCIHLI----NEEHMVSGA 342 A+ G D T R++ + + +L+ Y H I I + + +++G Sbjct: 230 NAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGY 289 Query: 343 DDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRL 402 DD + +W + K A H R +S + + VATGS S +R+ Sbjct: 290 DDFNCNVWD-TLKGDRAGVLAGHDNR----------VSCLGVTDDGMAVATGSWDSFLRI 338 Query: 403 W 403 W Sbjct: 339 W 339 >gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [Homo sapiens] Length = 514 Score = 77.8 bits (190), Expect = 2e-14 Identities = 56/236 (23%), Positives = 97/236 (41%), Gaps = 14/236 (5%) Query: 127 VAKEIQAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPR 186 VA +Q A A+ G + P +A+ S + K S +K +P+ Sbjct: 128 VALPLQTKADANRTAPSGSEYRHPGASDRPQPTAMNSIVMETGNTKNSALMAKKAPTMPK 187 Query: 187 AKKGAEGKPP--------GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFT 238 + PP GH V C+A+ ++ +G + I IW+ S + + T Sbjct: 188 P----QWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLT 243 Query: 239 GHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCV 298 GH V G+ + L+S D+ VK W++ N + GH AV LD + Sbjct: 244 GHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVL 303 Query: 299 TAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHL-INEEHMVSGADDGSVALWGL 352 RD T R+W + ++ + GH ++ + E +++G+ D ++ LW L Sbjct: 304 VTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDL 359 Score = 77.4 bits (189), Expect = 3e-14 Identities = 50/210 (23%), Positives = 99/210 (47%), Gaps = 13/210 (6%) Query: 142 LRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSH 201 L GH ++ ++V+ +FS +D + W +E + + GH S Sbjct: 242 LTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYH-----------GHLSA 290 Query: 202 VLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSH 261 V + + L + R IW+ ++ ++T +GH +AV+ + + Q+ + SH Sbjct: 291 VYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSH 350 Query: 262 DRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLV-F 320 D ++++W++ TL H+ +V A+ R +G D ++ WK P+ S + Sbjct: 351 DTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWKFPDGSFIQNL 409 Query: 321 YGHQGSIDCIHLINEEHMVSGADDGSVALW 350 GH I+ + + ++ +VSGAD+G++ LW Sbjct: 410 SGHNAIINTLTVNSDGVLVSGADNGTMHLW 439 Score = 34.7 bits (78), Expect = 0.19 Identities = 36/180 (20%), Positives = 71/180 (39%), Gaps = 39/180 (21%) Query: 137 ADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKG------ 190 A + L GH ++ + + I + + D +I W + +G+ + KK Sbjct: 321 ASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVL 380 Query: 191 -------AEGKP-----------------PGHSSHVLCMAISSDGKYLASGDRSKLILIW 226 A G P GH++ + + ++SDG L SG + + +W Sbjct: 381 HPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGADNGTMHLW 439 Query: 227 EAQSCQ-----HLYTFTGHRDAVSGL---AFRRGTHQLYSTSHDRSVKVWNVAENSYVET 278 + ++ H G D+ SG+ AF + +L + D+++KV+ + + ET Sbjct: 440 DWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVYREDDTATEET 499 >gi|19913369 transducin beta-like 3 [Homo sapiens] Length = 808 Score = 77.4 bits (189), Expect = 3e-14 Identities = 51/208 (24%), Positives = 93/208 (44%), Gaps = 24/208 (11%) Query: 158 DSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPG-------------HSSHVLC 204 +S + + ++DC++ W +P+A P H + Sbjct: 434 ESFLVTGSQDCTVKLWP---------LPKALLSKNTAPDNGPILLQAQTTQRCHDKDINS 484 Query: 205 MAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRS 264 +AI+ + K LA+G + + +W CQ L F+GHR + + F L + S D + Sbjct: 485 VAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGT 544 Query: 265 VKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIP-EESQLVFYGH 323 +K+W + + S ++T GH +V + +SR + + G DG V++W I E H Sbjct: 545 IKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAH 604 Query: 324 QGSIDCIHLIN-EEHMVSGADDGSVALW 350 + + +H ++H ++GA D V LW Sbjct: 605 EDKVWGLHCSRLDDHALTGASDSRVILW 632 Score = 70.1 bits (170), Expect = 4e-12 Identities = 78/329 (23%), Positives = 130/329 (39%), Gaps = 74/329 (22%) Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 198 + VL H ++T L + D + S+ +D I W ++S + +P + E Sbjct: 188 LAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVP-VFESVEAAVLLP 246 Query: 199 SSHVLCMAISSDGKY-LASGDRSKLILIWEAQSCQHLYT--------------------- 236 V + + S G Y L +GD+ L +WEA S Q +YT Sbjct: 247 EEPVSQLGVKSPGLYFLTAGDQGTL-RVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAG 305 Query: 237 ------------------------FTGHRDAVSGLAFR--RGTHQLYSTSHDRSVKVWNV 270 F G+ + V + F +H + + S+ +KV+ + Sbjct: 306 VVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVA-SNSPCLKVFEL 364 Query: 271 AENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFY----GHQGS 326 + S + L GH D V ALD + + +D +VR+W++ + Q++ GH S Sbjct: 365 -QTSACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHS 423 Query: 327 ID--CIHLINEEHMVSGADDGSVALWGLSK----------KRPLALQREAHGLRGEPGLE 374 + C + E +V+G+ D +V LW L K P+ LQ + + Sbjct: 424 VGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKD-- 481 Query: 375 QPFWISSVAALLNTDLVATGSHSSCVRLW 403 I+SVA N L+ATGS +LW Sbjct: 482 ----INSVAIAPNDKLLATGSQDRTAKLW 506 Score = 70.1 bits (170), Expect = 4e-12 Identities = 50/176 (28%), Positives = 76/176 (43%), Gaps = 13/176 (7%) Query: 143 RGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHV 202 R H I + + P+D + + ++D + W++ + L V GH + Sbjct: 476 RCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFS-----------GHRRGL 524 Query: 203 LCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAF-RRGTHQLYSTSH 261 C+ S + LA+ I +W Q L TF GH +V +AF RGT QL S+ Sbjct: 525 WCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGT-QLLSSGS 583 Query: 262 DRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQ 317 D VK+W + N V TL H+D V L + G D V +WK E++ Sbjct: 584 DGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWKDVTEAE 639 Score = 56.6 bits (135), Expect = 5e-08 Identities = 54/266 (20%), Positives = 107/266 (40%), Gaps = 30/266 (11%) Query: 146 QLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLCM 205 Q IT ++PD+ + +A++ + +W+ + G + R K H++ V M Sbjct: 66 QEDITAFDLSPDNEVLVTASRALLLAQWAWQEGS----VTRLWKAI------HTAPVATM 115 Query: 206 AISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQL--YSTSHDR 263 A LA+G + +W+ + F G V +AF +L +S++ D Sbjct: 116 AFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDA 175 Query: 264 SVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYGH 323 +++VW++ + S + L H AV +L + + + GRD +W + Sbjct: 176 AIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPV 235 Query: 324 QGSIDCIHLINEE------------HMVSGADDGSVALWGLSKKRPLALQREAHGLRGEP 371 S++ L+ EE + ++ D G++ +W + + + Q + P Sbjct: 236 FESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQ------PP 289 Query: 372 GLEQPFWISSVAALLNTDLVATGSHS 397 G Q ++A L AT H+ Sbjct: 290 GPGQELTHCTLAHTAGVVLTATADHN 315 Score = 48.5 bits (114), Expect = 1e-05 Identities = 40/155 (25%), Positives = 62/155 (40%), Gaps = 12/155 (7%) Query: 124 QKLVAKEIQAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHV 183 Q AK P + V GH+ + C+ +P D + +A+ D +I W+++ L Sbjct: 499 QDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKT 558 Query: 184 IPRAKKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDA 243 GH + VL +A S G L S L+ +W ++ + + T H D Sbjct: 559 F-----------EGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDK 607 Query: 244 VSGL-AFRRGTHQLYSTSHDRSVKVWNVAENSYVE 277 V GL R H L S R + +V E E Sbjct: 608 VWGLHCSRLDDHALTGASDSRVILWKDVTEAEQAE 642 >gi|5803221 WD repeat-containing protein 3 [Homo sapiens] Length = 943 Score = 77.0 bits (188), Expect = 3e-14 Identities = 52/176 (29%), Positives = 82/176 (46%), Gaps = 15/176 (8%) Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPP-- 196 I +L+G + +TCL +PD + +D SI +S+ SG EG Sbjct: 58 ILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSG-------------EGNVTFN 104 Query: 197 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQL 256 GH + + + G LASG + I++W+ + LY GH+DA++ F R + L Sbjct: 105 GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLL 164 Query: 257 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKI 312 ++ D VK W++ +T+ GH+ V L LS E + G D +RVW I Sbjct: 165 VTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220 Score = 74.3 bits (181), Expect = 2e-13 Identities = 58/231 (25%), Positives = 103/231 (44%), Gaps = 15/231 (6%) Query: 126 LVAKEIQAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCS-IIKWSVESGRKLHVI 184 L + ++ ASA V+ G Q V + + A C + W + G K+ ++ Sbjct: 3 LTKQYLRYVASAVFGVI-GSQKGNIVFVTLRGEKGRYVAVPACEHVFIWDLRKGEKILIL 61 Query: 185 PRAKKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAV 244 K+ V C+ S DG +LA G I I+ S + TF GH+ A+ Sbjct: 62 QGLKQ-----------EVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAI 110 Query: 245 SGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRD 304 + L + + +L S S D + VW+V S + L GH+DA+ L + + G+D Sbjct: 111 TTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKD 170 Query: 305 GTVRVWKIPEESQL-VFYGHQGSIDCIHLINEE-HMVSGADDGSVALWGLS 353 V+ W + + GH+ + + L++EE +++GA D + +W ++ Sbjct: 171 TMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIA 221 Score = 62.8 bits (151), Expect = 7e-10 Identities = 48/227 (21%), Positives = 98/227 (43%), Gaps = 3/227 (1%) Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 198 + + H ++ + ++PD + D S+ W E + + + + + Sbjct: 489 LETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQL 548 Query: 199 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYS 258 VLC++ S + K LA + I+ + + + GH+ V + + + Sbjct: 549 DEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIAT 608 Query: 259 TSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPE-ESQ 317 S DR+VK+W + ++LF H D+V L + + G+D ++ W + E Sbjct: 609 GSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHI 668 Query: 318 LVFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALQRE 363 GH I C+ + + +++VS + D S+ LW +++ PL L+ E Sbjct: 669 QTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTRE-PLILEEE 714 Score = 52.8 bits (125), Expect = 7e-07 Identities = 79/410 (19%), Positives = 153/410 (37%), Gaps = 72/410 (17%) Query: 44 KMNEEISSDSESESLAPRKPEEEEEE-ELEETAQEKKLRLAKLYLEQLRQQEEEKAEARA 102 KM++++ + L K EEE+ E +E + Q++ R+ + + A+ ++ Sbjct: 317 KMDKKMKKARKKAKLHSSKGEEEDPEVNVEMSLQDEIQRVTNI---------KTSAKIKS 367 Query: 103 FEE-DQVAGRLKEDVLEQRGRLQKLVAKEIQAPASADIRVLR----GHQLSITCLVVTPD 157 F+ G LK L Q L +L + P +R R GH+ + L + D Sbjct: 368 FDLIHSPHGELKAVFLLQNN-LVELYSLNPSLPTPQPVRTSRITIGGHRSDVRTLSFSSD 426 Query: 158 DSAIFSAAKDCSIIKWSVESGRKLHV-----------IPRAKKGAEGKPPG--------- 197 + A+ SAA D SI W+ + + + +P ++ G G Sbjct: 427 NIAVLSAAAD-SIKIWNRSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLAS 485 Query: 198 ---------HSSHVLCMAISSDGKYLASGDRSKLILIWEAQ------------SCQHLYT 236 H + M++S D + +G K + W+ + S + T Sbjct: 486 GNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRT 545 Query: 237 FTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSREC 296 D + +++ L + D +VK++ V + +L+GH+ V +D Sbjct: 546 LQLDEDVLC-VSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGA 604 Query: 297 CVTAGGRDGTVRVWKIP-EESQLVFYGHQGSIDCIHLINEEHMV-SGADDGSVALWGLSK 354 + G D V++W + + + H S+ + + + H+ + D + W K Sbjct: 605 LIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADK 664 Query: 355 KRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQ 404 + H Q W +V+ + D V + SH +RLW+ Sbjct: 665 FEHIQTLEGHH---------QEIWCLAVSP--SGDYVVSSSHDKSLRLWE 703 Score = 44.3 bits (103), Expect = 2e-04 Identities = 30/134 (22%), Positives = 53/134 (39%), Gaps = 11/134 (8%) Query: 144 GHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVL 203 GH+ +IT L + S +KD II W V + L+ + GH + Sbjct: 105 GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLK-----------GHKDAIT 153 Query: 204 CMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDR 263 + L + + ++ W+ + T GHR V GL +L + + D Sbjct: 154 QALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDS 213 Query: 264 SVKVWNVAENSYVE 277 ++VW++A +E Sbjct: 214 ELRVWDIAYLQEIE 227 >gi|72534670 phospholipase A2-activating protein [Homo sapiens] Length = 795 Score = 75.9 bits (185), Expect = 8e-14 Identities = 74/273 (27%), Positives = 118/273 (43%), Gaps = 31/273 (11%) Query: 142 LRGHQLSITCLVVTP-DDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSS 200 LRGH+L + LV A S ++D + W+ +S + G HS+ Sbjct: 14 LRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSG-------HSN 66 Query: 201 HVLCMAI--SSD---GKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRR-GTH 254 V C+ I SSD +A+G I I+ S LY GH++ V L+ + GT Sbjct: 67 FVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGT- 125 Query: 255 QLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPE 314 L S S D + KVW + + TL GH AV A+ L + + G D TV++WK Sbjct: 126 -LLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWK-AG 181 Query: 315 ESQLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLE 374 + F GH+ + + +++E +S A+D S+ W ++ G E Sbjct: 182 RCERTFSGHEDCVRGLAILSETEFLSCANDASIRRWQIT------------GECLEVYYG 229 Query: 375 QPFWISSVAALLNTDLVATGSHSSCVRLWQCGE 407 +I S++ N T + +R+W+ GE Sbjct: 230 HTNYIYSISVFPNCRDFVTTAEDRSLRIWKHGE 262 Score = 69.7 bits (169), Expect = 5e-12 Identities = 60/270 (22%), Positives = 115/270 (42%), Gaps = 38/270 (14%) Query: 120 RGRLQKLVAKEIQAPASADIRVLRGHQLSITCLVVTPDD-----SAIFSAAKDCSIIKWS 174 R R +L A + + ++ + GH ++C+ + P I + D +I +S Sbjct: 39 RDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFS 98 Query: 175 VESGRKLHVIPRAKKG----AEGK------------------------PPGHSSHVLCMA 206 ++S L+++ K + GK GH++ V + Sbjct: 99 LDSPMPLYILKGHKNTVCSLSSGKFGTLLSGSWDTTAKVWLNDKCMMTLQGHTAAVWAVK 158 Query: 207 ISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVK 266 I + + +G K + +W+A C+ TF+GH D V GLA T + S ++D S++ Sbjct: 159 ILPEQGLMLTGSADKTVKLWKAGRCER--TFSGHEDCVRGLAILSET-EFLSCANDASIR 215 Query: 267 VWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYGHQGS 326 W + +E +GH + + ++ D ++R+WK E +Q + Q S Sbjct: 216 RWQIT-GECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIWKHGECAQTIRLPAQ-S 273 Query: 327 IDCIHLINEEHMVSGADDGSVALWGLSKKR 356 I C +++ +V GA DG + ++ S+ R Sbjct: 274 IWCCCVLDNGDIVVGASDGIIRVFTESEDR 303 >gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo sapiens] Length = 340 Score = 75.1 bits (183), Expect = 1e-13 Identities = 80/361 (22%), Positives = 136/361 (37%), Gaps = 69/361 (19%) Query: 87 LEQLRQQEEEK----AEARAFEEDQVAGRLKEDVLEQRGRLQKLVAKEIQAPASADIRVL 142 +EQLRQ+ E+ A+AR D L LE GR+Q R L Sbjct: 4 MEQLRQEAEQLKKQIADARKACADVTLAELVSG-LEVVGRVQMRTR-----------RTL 51 Query: 143 RGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAK-------------- 188 RGH I + D + SA++D +I W + K+H IP Sbjct: 52 RGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNF 111 Query: 189 ---------------KGAEG------KPPGHSSHVLCMAISSDGKYL-ASGDRSKLILIW 226 K EG + H+ ++ C D + +SGD + +W Sbjct: 112 VACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTT--CALW 169 Query: 227 EAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAV 286 + ++ Q F GH LA + S + D S K+W+V E + +T GH+ + Sbjct: 170 DIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDI 229 Query: 287 AALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYGHQ----GSIDCIHLINEEHMVSGA 342 A+ + G D + R++ + + +L+ + H+ G ++ + +G Sbjct: 230 NAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGY 289 Query: 343 DDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRL 402 DD + +W K + + H R +S + + VATGS S +++ Sbjct: 290 DDFNCNVWDSMKSERVGI-LSGHDNR----------VSCLGVTADGMAVATGSWDSFLKI 338 Query: 403 W 403 W Sbjct: 339 W 339 Score = 35.0 bits (79), Expect = 0.15 Identities = 28/130 (21%), Positives = 54/130 (41%), Gaps = 17/130 (13%) Query: 144 GHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVL 203 GH+ I + P+ AI + + D S + + + ++L H S ++ Sbjct: 224 GHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICF------------SHES-II 270 Query: 204 C----MAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYST 259 C +A S G+ L +G +W++ + + +GH + VS L + + Sbjct: 271 CGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATG 330 Query: 260 SHDRSVKVWN 269 S D +K+WN Sbjct: 331 SWDSFLKIWN 340 >gi|83779014 katanin p80 subunit B 1 [Homo sapiens] Length = 655 Score = 74.7 bits (182), Expect = 2e-13 Identities = 52/203 (25%), Positives = 93/203 (45%), Gaps = 13/203 (6%) Query: 135 ASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGK 194 A+ +R L GH+ +I L P + S ++D +I W + +KG + Sbjct: 94 AAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIR-----------RKGCVFR 142 Query: 195 PPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTH 254 GHS V C+ S DGK+LAS + +W+ + + + F GH V+ + F + Sbjct: 143 YRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEY 202 Query: 255 QLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDG-TVRVWKIP 313 L S S DR+++ W++ + V + G V ++ CC+ +G +D V W+ P Sbjct: 203 LLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWE-P 261 Query: 314 EESQLVFYGHQGSIDCIHLINEE 336 E V + G + + + N++ Sbjct: 262 ERCFDVVLVNWGKVADLAICNDQ 284 Score = 73.9 bits (180), Expect = 3e-13 Identities = 52/231 (22%), Positives = 101/231 (43%), Gaps = 20/231 (8%) Query: 145 HQLSITCLVVTPDDSAIFSAA-KDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVL 203 H +++ LV+ + + DC + WS+ + + GH+S V Sbjct: 19 HASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLT-----------GHTSPVE 67 Query: 204 CMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDR 263 + +++ + + +G +S I +W+ ++ + L T GH+ + L F + S S D Sbjct: 68 SVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDT 127 Query: 264 SVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL-VFYG 322 ++K+W++ V GH AV L + + D TV++W + + F G Sbjct: 128 NIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPG 187 Query: 323 HQGSIDCIHL-INEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPG 372 H G ++ + NE + SG+ D ++ W L K + ++ + GEPG Sbjct: 188 HTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSC------IEGEPG 232 Score = 67.8 bits (164), Expect = 2e-11 Identities = 52/222 (23%), Positives = 99/222 (44%), Gaps = 18/222 (8%) Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 198 I L GH + + + + I + ++ SI W +E+ + L + GH Sbjct: 56 IMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTL-----------MGH 104 Query: 199 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYS 258 +++ + G+++ASG + I +W+ + ++ + GH AV L F L S Sbjct: 105 KANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLAS 164 Query: 259 TSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL 318 + D +VK+W++ + GH V ++ E + +G D T+R W + E+ Q+ Sbjct: 165 AADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDL-EKFQV 223 Query: 319 V--FYGHQGSIDCIHLINEEH--MVSGADDGSVALWGLSKKR 356 V G G + + L N + + SG D S+ ++G +R Sbjct: 224 VSCIEGEPGPVRSV-LFNPDGCCLYSGCQD-SLRVYGWEPER 263 >gi|32189425 WD repeat domain 69 [Homo sapiens] Length = 415 Score = 74.7 bits (182), Expect = 2e-13 Identities = 70/322 (21%), Positives = 134/322 (41%), Gaps = 40/322 (12%) Query: 138 DIRVLRGHQLSITCLVVTP---DDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGK 194 ++ L GH+ + + D A S K C + WSVE+G+ H Sbjct: 126 ELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKL--WSVETGKCYHTFR--------- 174 Query: 195 PPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTH 254 GH++ ++C++ + +A+G +W+ Q+ + +YT GH + L+F Sbjct: 175 --GHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGD 232 Query: 255 QLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSREC-CVTAGGRDGTVRVWKIP 313 ++ + S D +V VW+ V L GH +++ + + +C + G D T ++W Sbjct: 233 RIITGSFDHTVVVWDADTGRKVNILIGHCAEISSA-SFNWDCSLILTGSMDKTCKLWDAT 291 Query: 314 E-ESQLVFYGHQGSI-DCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEP 371 + GH I D + + + + DG+ ++ + ++ +A + G GE Sbjct: 292 NGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIA---KLEGHEGE- 347 Query: 372 GLEQPFWISSVAALLNTDLVATGSHSSCVRLW--QCGEGFRQLDLLCDIPLVGFINSLKF 429 IS ++ + + TGS R+W Q G+ + L+ D I S F Sbjct: 348 -------ISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTD-----EIFSCAF 395 Query: 430 SSSGDFLVAGVGQEHRLGRWWR 451 + G+ ++ G + R WR Sbjct: 396 NYKGNIVI--TGSKDNTCRIWR 415 Score = 67.4 bits (163), Expect = 3e-11 Identities = 48/207 (23%), Positives = 83/207 (40%), Gaps = 14/207 (6%) Query: 205 MAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYST-SHDR 263 +A++ G +G + +W+ S + L T GHR+ V +AF +T S D+ Sbjct: 98 VALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDK 157 Query: 264 SVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPE-ESQLVFYG 322 + K+W+V T GH + L + V G D T ++W I E G Sbjct: 158 TCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRG 217 Query: 323 HQGSIDCIHL-INEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISS 381 H I + + + +++G+ D +V +W R + + + ISS Sbjct: 218 HSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNIL-----------IGHCAEISS 266 Query: 382 VAALLNTDLVATGSHSSCVRLWQCGEG 408 + + L+ TGS +LW G Sbjct: 267 ASFNWDCSLILTGSMDKTCKLWDATNG 293 Score = 59.7 bits (143), Expect = 6e-09 Identities = 37/179 (20%), Positives = 72/179 (40%), Gaps = 11/179 (6%) Query: 133 APASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAE 192 A + +L GH I+ D S I + + D + W +G+ + + Sbjct: 248 ADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATL-------- 299 Query: 193 GKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRG 252 GH +L GK +A+ I+ A + + + GH +S ++F Sbjct: 300 ---TGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQ 356 Query: 253 THQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWK 311 + L + S D++ ++W+ ++ L GH D + + + V G +D T R+W+ Sbjct: 357 GNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415 Score = 52.0 bits (123), Expect = 1e-06 Identities = 52/225 (23%), Positives = 98/225 (43%), Gaps = 24/225 (10%) Query: 244 VSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSREC--CVTAG 301 ++ +A + + S+DR+ K+W+ A + TL GH++ V A+ A + + G Sbjct: 95 LTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAI-AFNNPYGDKIATG 153 Query: 302 GRDGTVRVWKIPE-ESQLVFYGHQGSIDCIHLINEEHMV-SGADDGSVALWGLSKKRPLA 359 D T ++W + + F GH I C+ + +V +G+ D + LW + Sbjct: 154 SFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQN----- 208 Query: 360 LQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIP 419 E + LRG I S++ + D + TGS V +W G R++++L I Sbjct: 209 -GEEVYTLRGHSA-----EIISLSFNTSGDRIITGSFDHTVVVWDADTG-RKVNIL--IG 259 Query: 420 LVGFINSLKFSSSGDFLVAGVGQEHRLGRWWRIKEARNSVCIIPL 464 I+S F+ ++ G + + ++ +A N C+ L Sbjct: 260 HCAEISSASFNWDCSLILTG-----SMDKTCKLWDATNGKCVATL 299 Score = 32.7 bits (73), Expect = 0.74 Identities = 20/99 (20%), Positives = 39/99 (39%), Gaps = 11/99 (11%) Query: 128 AKEIQAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRA 187 A+ A I L GH+ I+ + P + + + + D + W ++G+ L V+ Sbjct: 327 ARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVL--- 383 Query: 188 KKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIW 226 GH+ + A + G + +G + IW Sbjct: 384 --------EGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414 >gi|102470001 PQQ repeat and WD repeat domain containing [Homo sapiens] Length = 472 Score = 74.3 bits (181), Expect = 2e-13 Identities = 65/287 (22%), Positives = 122/287 (42%), Gaps = 57/287 (19%) Query: 154 VTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKY 213 +T D S + +A+ D ++ W +E+G+ L + + + ++ S DGKY Sbjct: 153 ITGDSSRVIAASYDKTVRAWDLETGKLLWKVR------------YDTFIVSCKFSPDGKY 200 Query: 214 LASG-DRSKLILIWEAQSCQHLYTFTGHRD-AVSGLAFRRGTHQLYSTSHDRSVKVWNVA 271 + SG D I I +A++ + H +++ F + ++ S S DR +K+W+V Sbjct: 201 VVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVT 260 Query: 272 ENSYVETLF-GHQDAVAALDALSRECCVTAGGR-------DGTVRVWKIPEES------- 316 + + T+ H +A++ CC T G D +++W + Sbjct: 261 SQATLLTITKAHSNAIS-------NCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGAC 313 Query: 317 QLVFYGHQGSIDCIHLINEEH-MVSGADDGSVALWGLSKK-RPLALQREAHGLRGEPGLE 374 + GH+GS+ H + ++SG D +VA+W +++ R L+L+ Sbjct: 314 VTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHND--------- 364 Query: 375 QPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPLV 421 W+ VA N + + S +RLW E + +IPLV Sbjct: 365 ---WVMDVAISNNKKWILSASKDRTMRLWNIEE-------IDEIPLV 401 Score = 68.9 bits (167), Expect = 9e-12 Identities = 51/180 (28%), Positives = 78/180 (43%), Gaps = 16/180 (8%) Query: 145 HQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLC 204 H SIT PD + S + D I W V S L I +A HS+ + Sbjct: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKA----------HSNAISN 278 Query: 205 MAISSDGKYLASGDRSKLILIW-----EAQSCQHLYTFT-GHRDAVSGLAFRRGTHQLYS 258 + G +L + K + IW E ++C T GH +VS F R + L S Sbjct: 279 CCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLIS 338 Query: 259 TSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL 318 DR+V +W+VAE +L GH D V + + + + + +D T+R+W I E ++ Sbjct: 339 GGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEI 398 >gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] Length = 359 Score = 73.9 bits (180), Expect = 3e-13 Identities = 66/246 (26%), Positives = 102/246 (41%), Gaps = 22/246 (8%) Query: 197 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQL 256 GH V C+ S + K LASG +++W + Y FTGH+DAV+ + F H L Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76 Query: 257 YSTSHDRSVKVW--NVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPE 314 S S D++V++W NV S V H V ++ S D TV+VW Sbjct: 77 ASGSRDKTVRIWVPNVKGESTV--FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134 Query: 315 ESQLVFYG-HQGSIDCIHLINEEHM-VSGADDGSVALWGLSKKRPLALQREAHGLRGEPG 372 + L H + C + + VS +DD +V LW S + + E G Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGG------ 188 Query: 373 LEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPL-VGFINSLKFSS 431 +++ V + +A + V++W R LL L +N L F Sbjct: 189 -----FVTYVDFHPSGTCIAAAGMDNTVKVWD----VRTHRLLQHYQLHSAAVNGLSFHP 239 Query: 432 SGDFLV 437 SG++L+ Sbjct: 240 SGNYLI 245 Score = 72.8 bits (177), Expect = 6e-13 Identities = 56/222 (25%), Positives = 99/222 (44%), Gaps = 31/222 (13%) Query: 237 FTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSREC 296 F GHRDAV+ + F T QL S S D + VW++ S GH+DAV ++ Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74 Query: 297 CVTAGGRDGTVRVWKIP--EESQLVFYGHQGSIDCIHLINE-EHMVSGADDGSVALWGLS 353 + +G RD TVR+W +P + VF H ++ +H ++ + V+ +DD +V +W Sbjct: 75 LLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATH 133 Query: 354 KKRPL-ALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLW-----QCGE 407 +++ L +L + + W+ + L+ + S V+LW +C Sbjct: 134 RQKFLFSLSQHIN------------WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVH 181 Query: 408 GFRQLDLLCDIPLVGFINSLKFSSSGDFLVAGVGQEHRLGRW 449 + + GF+ + F SG +A G ++ + W Sbjct: 182 SYCEHG--------GFVTYVDFHPSGT-CIAAAGMDNTVKVW 214 Score = 70.9 bits (172), Expect = 2e-12 Identities = 56/263 (21%), Positives = 111/263 (42%), Gaps = 24/263 (9%) Query: 144 GHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVL 203 GH+ ++TC+ +P + S ++D ++ W +P KG H++ V Sbjct: 59 GHKDAVTCVNFSPSGHLLASGSRDKTVRIW----------VPNV-KGESTVFRAHTATVR 107 Query: 204 CMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDR 263 + SDG+ + K + +W + L++ + H + V F + S S D+ Sbjct: 108 SVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDK 167 Query: 264 SVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYG- 322 +VK+W+ + V + H V +D C+ A G D TV+VW + L Y Sbjct: 168 TVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL 227 Query: 323 HQGSIDCIHL-INEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISS 381 H +++ + + ++++ + D ++ + L + R L HG +G ++ Sbjct: 228 HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGR---LLYTLHGHQGP--------ATT 276 Query: 382 VAALLNTDLVATGSHSSCVRLWQ 404 VA + A+G V +W+ Sbjct: 277 VAFSRTGEYFASGGSDEQVMVWK 299 Score = 61.6 bits (148), Expect = 1e-09 Identities = 45/212 (21%), Positives = 86/212 (40%), Gaps = 13/212 (6%) Query: 141 VLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSS 200 V R H ++ + D + +A+ D ++ W+ + L + + H + Sbjct: 98 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQ-----------HIN 146 Query: 201 HVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTS 260 V C S DG+ + S K + +W+ S + ++++ H V+ + F + + Sbjct: 147 WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAG 206 Query: 261 HDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL-V 319 D +VKVW+V + ++ H AV L + D T+++ + E L Sbjct: 207 MDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYT 266 Query: 320 FYGHQGSIDCIHLINE-EHMVSGADDGSVALW 350 +GHQG + E+ SG D V +W Sbjct: 267 LHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298 Score = 33.5 bits (75), Expect = 0.43 Identities = 18/84 (21%), Positives = 37/84 (44%), Gaps = 11/84 (13%) Query: 145 HQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLC 204 H ++ L P + + +A+ D ++ + GR L+ + GH Sbjct: 228 HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLH-----------GHQGPATT 276 Query: 205 MAISSDGKYLASGDRSKLILIWEA 228 +A S G+Y ASG + +++W++ Sbjct: 277 VAFSRTGEYFASGGSDEQVMVWKS 300 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.316 0.132 0.392 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 19,690,572 Number of Sequences: 37866 Number of extensions: 970917 Number of successful extensions: 18309 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 414 Number of HSP's successfully gapped in prelim test: 587 Number of HSP's that attempted gapping in prelim test: 10157 Number of HSP's gapped (non-prelim): 5302 length of query: 475 length of database: 18,247,518 effective HSP length: 106 effective length of query: 369 effective length of database: 14,233,722 effective search space: 5252243418 effective search space used: 5252243418 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.