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Search of human proteins with 4757880
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4757880 budding uninhibited by benzimidazoles 3 isoform a
[Homo sapiens]
(328 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4757880 budding uninhibited by benzimidazoles 3 isoform a [Ho... 687 0.0
gi|56550081 budding uninhibited by benzimidazoles 3 isoform b [H... 679 0.0
gi|4506399 RAE1 (RNA export 1, S.pombe) homolog [Homo sapiens] 193 2e-49
gi|62739173 RAE1 (RNA export 1, S.pombe) homolog [Homo sapiens] 193 2e-49
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 64 1e-10
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 64 1e-10
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 64 2e-10
gi|32189425 WD repeat domain 69 [Homo sapiens] 60 3e-09
gi|50980309 UTP15, U3 small nucleolar ribonucleoprotein, homolog... 58 1e-08
gi|113865883 WD repeat domain 38 [Homo sapiens] 57 2e-08
gi|23199987 WD repeat domain 5B [Homo sapiens] 57 2e-08
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 56 5e-08
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 56 5e-08
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 55 7e-08
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 55 1e-07
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 54 2e-07
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is... 54 2e-07
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i... 54 2e-07
gi|26665869 WD repeat domain 51B [Homo sapiens] 54 2e-07
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [... 52 6e-07
gi|217330644 WD repeat domain 12 protein [Homo sapiens] 52 9e-07
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 50 2e-06
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 50 2e-06
gi|14150171 THO complex 3 [Homo sapiens] 50 2e-06
gi|4506439 retinoblastoma binding protein 7 [Homo sapiens] 50 3e-06
gi|207029439 retinoblastoma binding protein 4 isoform c [Homo sa... 50 4e-06
gi|207029415 retinoblastoma binding protein 4 isoform b [Homo sa... 50 4e-06
gi|5032027 retinoblastoma binding protein 4 isoform a [Homo sapi... 50 4e-06
gi|16554629 WD repeat domain 5 [Homo sapiens] 49 5e-06
gi|16554627 WD repeat domain 5 [Homo sapiens] 49 5e-06
>gi|4757880 budding uninhibited by benzimidazoles 3 isoform a [Homo
sapiens]
Length = 328
Score = 687 bits (1772), Expect = 0.0
Identities = 328/328 (100%), Positives = 328/328 (100%)
Query: 1 MTGSNEFKLNQPPEDGISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVL 60
MTGSNEFKLNQPPEDGISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVL
Sbjct: 1 MTGSNEFKLNQPPEDGISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVL 60
Query: 61 DCAFYDPTHAWSGGLDHQLKMHDLNTDQENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTV 120
DCAFYDPTHAWSGGLDHQLKMHDLNTDQENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTV
Sbjct: 61 DCAFYDPTHAWSGGLDHQLKMHDLNTDQENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTV 120
Query: 121 KLWDPRTPCNAGTFSQPEKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKY 180
KLWDPRTPCNAGTFSQPEKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKY
Sbjct: 121 KLWDPRTPCNAGTFSQPEKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKY 180
Query: 181 QTRCIRAFPNKQGYVLSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAI 240
QTRCIRAFPNKQGYVLSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAI
Sbjct: 181 QTRCIRAFPNKQGYVLSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAI 240
Query: 241 SFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASSYMYE 300
SFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASSYMYE
Sbjct: 241 SFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASSYMYE 300
Query: 301 MDDTEHPEDGIFIRQVTDAETKPKSPCT 328
MDDTEHPEDGIFIRQVTDAETKPKSPCT
Sbjct: 301 MDDTEHPEDGIFIRQVTDAETKPKSPCT 328
>gi|56550081 budding uninhibited by benzimidazoles 3 isoform b [Homo
sapiens]
Length = 326
Score = 679 bits (1751), Expect = 0.0
Identities = 325/325 (100%), Positives = 325/325 (100%)
Query: 1 MTGSNEFKLNQPPEDGISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVL 60
MTGSNEFKLNQPPEDGISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVL
Sbjct: 1 MTGSNEFKLNQPPEDGISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVL 60
Query: 61 DCAFYDPTHAWSGGLDHQLKMHDLNTDQENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTV 120
DCAFYDPTHAWSGGLDHQLKMHDLNTDQENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTV
Sbjct: 61 DCAFYDPTHAWSGGLDHQLKMHDLNTDQENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTV 120
Query: 121 KLWDPRTPCNAGTFSQPEKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKY 180
KLWDPRTPCNAGTFSQPEKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKY
Sbjct: 121 KLWDPRTPCNAGTFSQPEKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKY 180
Query: 181 QTRCIRAFPNKQGYVLSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAI 240
QTRCIRAFPNKQGYVLSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAI
Sbjct: 181 QTRCIRAFPNKQGYVLSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAI 240
Query: 241 SFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASSYMYE 300
SFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASSYMYE
Sbjct: 241 SFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASSYMYE 300
Query: 301 MDDTEHPEDGIFIRQVTDAETKPKS 325
MDDTEHPEDGIFIRQVTDAETKPKS
Sbjct: 301 MDDTEHPEDGIFIRQVTDAETKPKS 325
>gi|4506399 RAE1 (RNA export 1, S.pombe) homolog [Homo sapiens]
Length = 368
Score = 193 bits (490), Expect = 2e-49
Identities = 116/338 (34%), Positives = 177/338 (52%), Gaps = 20/338 (5%)
Query: 6 EFKLNQPPEDGISSVKFSPNT--SQFLLVSSWDTSVRLYDVPANSMRL---KYQHTGAVL 60
+ ++ P+D I + FSP T FL+ SW VR ++V + + + HTG VL
Sbjct: 31 DIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVL 90
Query: 61 D-CAFYDPTHAWSGGLDHQLKMHDLNTDQENLVGTHDAPIRCVEY--CPEVNVMVTGSWD 117
D C D + ++ D KM DL+++Q + HDAP++ + + P + ++TGSWD
Sbjct: 91 DVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWD 150
Query: 118 QTVKLWDPRTPCNAGTFSQPEKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESS 177
+T+K WD R+ PE+ Y V +V TA R ++V+ L N +R ES
Sbjct: 151 KTLKFWDTRSSNPMMVLQLPERCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESP 210
Query: 178 LKYQTRCIRAFPNKQ----GYVLSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNI-- 231
LK+Q RC+ F +KQ G+ L SIEGRVA+ Y++P P K + FKCHR N
Sbjct: 211 LKHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINP-PNPAKDNFTFKCHRSNGTNTSA 269
Query: 232 -EQIYPVNAISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTT 290
+ IY VN I+FH +H T AT GSDG + WD + +L + I++ F+++G
Sbjct: 270 PQDIYAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNI 329
Query: 291 LAIASSYMYEMDD---TEHPEDGIFIRQVTDAETKPKS 325
A ASSY + ++ IF+R + E KP++
Sbjct: 330 FAYASSYDWSKGHEFYNPQKKNYIFLRNAAE-ELKPRN 366
>gi|62739173 RAE1 (RNA export 1, S.pombe) homolog [Homo sapiens]
Length = 368
Score = 193 bits (490), Expect = 2e-49
Identities = 116/338 (34%), Positives = 177/338 (52%), Gaps = 20/338 (5%)
Query: 6 EFKLNQPPEDGISSVKFSPNT--SQFLLVSSWDTSVRLYDVPANSMRL---KYQHTGAVL 60
+ ++ P+D I + FSP T FL+ SW VR ++V + + + HTG VL
Sbjct: 31 DIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVL 90
Query: 61 D-CAFYDPTHAWSGGLDHQLKMHDLNTDQENLVGTHDAPIRCVEY--CPEVNVMVTGSWD 117
D C D + ++ D KM DL+++Q + HDAP++ + + P + ++TGSWD
Sbjct: 91 DVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWD 150
Query: 118 QTVKLWDPRTPCNAGTFSQPEKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESS 177
+T+K WD R+ PE+ Y V +V TA R ++V+ L N +R ES
Sbjct: 151 KTLKFWDTRSSNPMMVLQLPERCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESP 210
Query: 178 LKYQTRCIRAFPNKQ----GYVLSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNI-- 231
LK+Q RC+ F +KQ G+ L SIEGRVA+ Y++P P K + FKCHR N
Sbjct: 211 LKHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINP-PNPAKDNFTFKCHRSNGTNTSA 269
Query: 232 -EQIYPVNAISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTT 290
+ IY VN I+FH +H T AT GSDG + WD + +L + I++ F+++G
Sbjct: 270 PQDIYAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNI 329
Query: 291 LAIASSYMYEMDD---TEHPEDGIFIRQVTDAETKPKS 325
A ASSY + ++ IF+R + E KP++
Sbjct: 330 FAYASSYDWSKGHEFYNPQKKNYIFLRNAAE-ELKPRN 366
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 64.3 bits (155), Expect = 1e-10
Identities = 69/298 (23%), Positives = 113/298 (37%), Gaps = 42/298 (14%)
Query: 15 DGISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVLDCAFYDPTHAW--S 72
D ++ V FS NT Q L S D+ + ++ + S ++ + C + P+ S
Sbjct: 20 DAVTCVDFSINTKQ-LASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLAS 78
Query: 73 GGLDHQLKMHDLNTDQENLV-GTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNA 131
G D +++ N E+ V H A +R V +C + VT S D+TVK+W
Sbjct: 79 GSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFL 138
Query: 132 GTFSQP---EKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCIRAF 188
+ SQ + S G ++ + + V +WD K C+ ++
Sbjct: 139 FSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD---------------KSSRECVHSY 183
Query: 189 PNKQGYVLSSIEGRVAVEYLDPSP----------EVQKKKYAFKCHRLKENNIEQIYPVN 238
G+V Y+D P + K + + HRL ++ VN
Sbjct: 184 CEHGGFVT----------YVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN 233
Query: 239 AISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASS 296
+SFH N T SD + I D + L H + ++AFS G A S
Sbjct: 234 GLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGS 291
Score = 39.7 bits (91), Expect = 0.004
Identities = 46/236 (19%), Positives = 85/236 (36%), Gaps = 38/236 (16%)
Query: 95 HDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFSQPEKVYT---LSVSGDRLI 151
H + CV++ + +GS D + +W + A F+ + T S SG L
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77
Query: 152 VGTAGRRVLVW----------------DLRNMGYVQQRRESSLKYQTRCIRAF-PNKQGY 194
G+ + V +W +R++ + + + ++ + ++Q +
Sbjct: 78 SGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF 137
Query: 195 VLS-------------SIEGRVAVEYLDPSPEVQKKKYAFKC-HRLKENNIEQIYPVNAI 240
+ S S +GR+ V D K + +C H E+ Y +
Sbjct: 138 LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTY----V 193
Query: 241 SFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASS 296
FH A G D V +WD + L + + ++ L+F G L ASS
Sbjct: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 64.3 bits (155), Expect = 1e-10
Identities = 69/298 (23%), Positives = 113/298 (37%), Gaps = 42/298 (14%)
Query: 15 DGISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVLDCAFYDPTHAW--S 72
D ++ V FS NT Q L S D+ + ++ + S ++ + C + P+ S
Sbjct: 20 DAVTCVDFSINTKQ-LASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLAS 78
Query: 73 GGLDHQLKMHDLNTDQENLV-GTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNA 131
G D +++ N E+ V H A +R V +C + VT S D+TVK+W
Sbjct: 79 GSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFL 138
Query: 132 GTFSQP---EKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCIRAF 188
+ SQ + S G ++ + + V +WD K C+ ++
Sbjct: 139 FSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD---------------KSSRECVHSY 183
Query: 189 PNKQGYVLSSIEGRVAVEYLDPSP----------EVQKKKYAFKCHRLKENNIEQIYPVN 238
G+V Y+D P + K + + HRL ++ VN
Sbjct: 184 CEHGGFVT----------YVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN 233
Query: 239 AISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASS 296
+SFH N T SD + I D + L H + ++AFS G A S
Sbjct: 234 GLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGS 291
Score = 39.7 bits (91), Expect = 0.004
Identities = 46/236 (19%), Positives = 85/236 (36%), Gaps = 38/236 (16%)
Query: 95 HDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFSQPEKVYT---LSVSGDRLI 151
H + CV++ + +GS D + +W + A F+ + T S SG L
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77
Query: 152 VGTAGRRVLVW----------------DLRNMGYVQQRRESSLKYQTRCIRAF-PNKQGY 194
G+ + V +W +R++ + + + ++ + ++Q +
Sbjct: 78 SGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF 137
Query: 195 VLS-------------SIEGRVAVEYLDPSPEVQKKKYAFKC-HRLKENNIEQIYPVNAI 240
+ S S +GR+ V D K + +C H E+ Y +
Sbjct: 138 LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTY----V 193
Query: 241 SFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASS 296
FH A G D V +WD + L + + ++ L+F G L ASS
Sbjct: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 63.9 bits (154), Expect = 2e-10
Identities = 77/295 (26%), Positives = 128/295 (43%), Gaps = 25/295 (8%)
Query: 14 EDGISSVKFSPNTSQFLLVSSWDTSVRLYDVPA---NSMRLKYQHTGAVLDCAFY-DPTH 69
E + KF PN S L + +D + L++V N LK H+GAV++ + D +
Sbjct: 66 EGEVYCCKFHPNGST-LASAGFDRLILLWNVYGDCDNYATLK-GHSGAVMELHYNTDGSM 123
Query: 70 AWSGGLDHQLKMHDLNTDQ--ENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRT 127
+S D + + D T + + L G C ++ TGS D TVKLWD R
Sbjct: 124 LFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRK 183
Query: 128 PCNAGTFSQPEKVY--TLSVSGDRLIVGTAGRRVLVWDLRN--MGYVQQRRESSLKYQTR 183
TF +V T + + D++I G + VWDLR + Y + S+ +
Sbjct: 184 KAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLS- 242
Query: 184 CIRAFPNKQGYVLSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAI--S 241
++ Y+LS+ V D P K++ C ++ + N+ + N + S
Sbjct: 243 ----LSSEGSYLLSNAMDNT-VRVWDVRPFAPKER----CVKIFQGNVHN-FEKNLLRCS 292
Query: 242 FHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASS 296
+ + A G +D FV +WD +++ L + + SI +AF D + ASS
Sbjct: 293 WSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASS 347
Score = 50.1 bits (118), Expect = 3e-06
Identities = 43/205 (20%), Positives = 82/205 (40%), Gaps = 19/205 (9%)
Query: 91 LVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCN--AGTFSQPEKVYTL--SVS 146
L+ H+ + C ++ P + + + +D+ + LW+ C+ A V L +
Sbjct: 61 LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTD 120
Query: 147 GDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCIRAFPNKQGYVLSSIEGRVAVE 206
G L + + V VWD G +R + + C A Q S +G V +
Sbjct: 121 GSMLFSASTDKTVAVWDSET-GERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLW 179
Query: 207 YLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAISFHNIHNTFATGGSDGFVNIWDPFNK 266
+ +KK A + + Y V A++F++ + +GG D + +WD
Sbjct: 180 DI-------RKKAAIQ-------TFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQN 225
Query: 267 KRLCQFHRYPTSIASLAFSNDGTTL 291
K + S+ L+ S++G+ L
Sbjct: 226 KLTYTMRGHADSVTGLSLSSEGSYL 250
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 59.7 bits (143), Expect = 3e-09
Identities = 77/326 (23%), Positives = 125/326 (38%), Gaps = 61/326 (18%)
Query: 17 ISSVKFSPNTSQFLLVSSWDTSVRLYDVPANS-MRLKYQHTGAVLDCAFYDP--THAWSG 73
+++V + + S F+ S+D + +L+D + + H V AF +P +G
Sbjct: 95 LTNVALNKSGSCFI-TGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATG 153
Query: 74 GLDHQLKMHDLNTDQ-ENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAG 132
D K+ + T + + H A I C+ + P+ ++ TGS D T KLWD
Sbjct: 154 SFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD-------- 205
Query: 133 TFSQPEKVYTL------------SVSGDRLIVGTAGRRVLVWDLRN-------MGYVQQR 173
E+VYTL + SGDR+I G+ V+VWD +G+ +
Sbjct: 206 -IQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEI 264
Query: 174 RESSLKYQTRCI---------RAFPNKQGYVLSSIEGRVAVEYLDPSPEVQKKKYAF--- 221
+S + I + + G ++++ G E LD + K A
Sbjct: 265 SSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGH-DDEILDSCFDYTGKLIATASA 323
Query: 222 ------------KCHRLKENNIEQIYPVNAISFHNIHNTFATGGSDGFVNIWDPFNKKRL 269
KC E + +I + ISF+ N TG SD IWD + L
Sbjct: 324 DGTARIFSAATRKCIAKLEGHEGEI---SKISFNPQGNHLLTGSSDKTARIWDAQTGQCL 380
Query: 270 CQFHRYPTSIASLAFSNDGTTLAIAS 295
+ I S AF+ G + S
Sbjct: 381 QVLEGHTDEIFSCAFNYKGNIVITGS 406
Score = 38.1 bits (87), Expect = 0.011
Identities = 36/153 (23%), Positives = 68/153 (44%), Gaps = 9/153 (5%)
Query: 17 ISSVKFSPNTSQFLLVSSWDTSVRLYDVP-ANSMRLKYQHTGAVLDCAF-YDPTHAWSGG 74
ISS F+ + S +L S D + +L+D + H +LD F Y +
Sbjct: 264 ISSASFNWDCS-LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATAS 322
Query: 75 LDHQLKMHDLNTDQ--ENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRT-PCNA 131
D ++ T + L G H+ I + + P+ N ++TGS D+T ++WD +T C
Sbjct: 323 ADGTARIFSAATRKCIAKLEG-HEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQ 381
Query: 132 GTFSQPEKVYT--LSVSGDRLIVGTAGRRVLVW 162
+++++ + G+ +I G+ +W
Sbjct: 382 VLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 36.6 bits (83), Expect = 0.031
Identities = 40/205 (19%), Positives = 79/205 (38%), Gaps = 19/205 (9%)
Query: 95 HDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTF-SQPEKVYTLSVS---GDRL 150
H P+ V + +TGS+D+T KLWD + T VY ++ + GD++
Sbjct: 91 HILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKI 150
Query: 151 IVGTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCIRAFPNKQGYVLSSIEGRVAVEYLDP 210
G+ + +W + R + + C+ P S++ + +
Sbjct: 151 ATGSFDKTCKLWSVETGKCYHTFRGHTA--EIVCLSFNPQSTLVATGSMDTTAKLWDIQN 208
Query: 211 SPEVQKKKYAFKCHRLKENNIEQIYPVNAISFHNIHNTFATGGSDGFVNIWDPFNKKRLC 270
EV Y + H + + ++SF+ + TG D V +WD +++
Sbjct: 209 GEEV----YTLRGHSAE---------IISLSFNTSGDRIITGSFDHTVVVWDADTGRKVN 255
Query: 271 QFHRYPTSIASLAFSNDGTTLAIAS 295
+ I+S +F+ D + + S
Sbjct: 256 ILIGHCAEISSASFNWDCSLILTGS 280
>gi|50980309 UTP15, U3 small nucleolar ribonucleoprotein, homolog
[Homo sapiens]
Length = 518
Score = 57.8 bits (138), Expect = 1e-08
Identities = 55/185 (29%), Positives = 91/185 (49%), Gaps = 10/185 (5%)
Query: 28 QFLLVSSWDTSVRLYDVPANSMRLKYQ-HTGAVLDCAFY-DPTHAWSGGLDHQLKMHDLN 85
+ L+ S D V+L+D+ + +++ HT AV F D H SG D+ +K+ D+
Sbjct: 93 RLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIP 152
Query: 86 TDQENLV-GTHDAPIRCVEYCPEVN--VMVTGSWDQTVKLWDPRTPCNAGTFS--QPEKV 140
+E L H +RC ++N + +TGS+D TVK++D RT + + QP +
Sbjct: 153 NSKEILTFKEHSDYVRC-GCASKLNPDLFITGSYDHTVKMFDARTSESVLSVEHGQPVES 211
Query: 141 YTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCIRAFPNKQGYVLSSIE 200
L SG L+V GR V VWD+ G + ++ K T C+ + Q + S++
Sbjct: 212 VLLFPSGG-LLVSAGGRYVKVWDMLKGGQLLVSLKNHHKTVT-CLCLSSSGQRLLSGSLD 269
Query: 201 GRVAV 205
+V V
Sbjct: 270 RKVKV 274
Score = 45.8 bits (107), Expect = 5e-05
Identities = 35/134 (26%), Positives = 60/134 (44%), Gaps = 8/134 (5%)
Query: 36 DTSVRLYDVPANSMRLKYQHTGAVLDCAF---YDPTHAWSGGLDHQLKMHDLNTDQENLV 92
D +V+L+D+P + L ++ + C +P +G DH +KM D T + L
Sbjct: 143 DYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLS 202
Query: 93 GTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWD----PRTPCNAGTFSQPEKVYTLSVSGD 148
H P+ V P ++V+ + VK+WD + + + LS SG
Sbjct: 203 VEHGQPVESVLLFPSGGLLVSAG-GRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQ 261
Query: 149 RLIVGTAGRRVLVW 162
RL+ G+ R+V V+
Sbjct: 262 RLLSGSLDRKVKVY 275
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 57.4 bits (137), Expect = 2e-08
Identities = 41/110 (37%), Positives = 60/110 (54%), Gaps = 6/110 (5%)
Query: 21 KFSPNTSQFLLVSSWDTSVRLYDVP-ANSMRLKYQHTGAVLDCAFY-DPTHAWSGGLDHQ 78
+FSP+ F S D +VRL+DV A +R+ H +V +F D SGG D +
Sbjct: 70 RFSPDGHLFASASC-DCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKR 128
Query: 79 LKMHDLNTDQ--ENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPR 126
+ + D+ + Q LVG D+ I+ ++ P VN + TGSWD TV +WD R
Sbjct: 129 VMLWDVQSGQMLRLLVGHRDS-IQSSDFSPTVNCLATGSWDSTVHIWDLR 177
Score = 53.9 bits (128), Expect = 2e-07
Identities = 47/157 (29%), Positives = 72/157 (45%), Gaps = 13/157 (8%)
Query: 17 ISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSM-RLKYQHTGAVLDCAFYDPTHAWS-GG 74
+ +V FSP++ Q L WD V L+DV + M RL H ++ F + + G
Sbjct: 108 VETVSFSPDSRQ-LASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGS 166
Query: 75 LDHQLKMHDLN-----TDQENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPC 129
D + + DL + L G H A I C+ Y ++ +GSWD+T+ +W P T
Sbjct: 167 WDSTVHIWDLRMVTPAVSHQALEG-HSANISCLCYSAS-GLLASGSWDKTIHIWKPTTSS 224
Query: 130 NAGTF-SQPEKVYTLSVSGDRLIVGTAG--RRVLVWD 163
V +++ S D L + +AG R V VWD
Sbjct: 225 LLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWD 261
Score = 50.4 bits (119), Expect = 2e-06
Identities = 51/214 (23%), Positives = 87/214 (40%), Gaps = 32/214 (14%)
Query: 92 VGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWD-PRTPCNAGTFSQPEKVYTLSVSGD-- 148
+G H P++ + P+ ++ + S D TV+LWD R C V T+S S D
Sbjct: 59 LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSR 118
Query: 149 RLIVGTAGRRVLVWDLRN-------MGYVQQRRESSLKYQTRCIRAFPNKQGYVLSSIEG 201
+L G +RV++WD+++ +G+ + S C+ S +
Sbjct: 119 QLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCL---------ATGSWDS 169
Query: 202 RVAV-EYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAISFHNIHNTFATGGSDGFVNI 260
V + + +P V H+ E + I + ++ A+G D ++I
Sbjct: 170 TVHIWDLRMVTPAVS--------HQALEGHSANI----SCLCYSASGLLASGSWDKTIHI 217
Query: 261 WDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIA 294
W P L Q + T + S+AFS D LA A
Sbjct: 218 WKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASA 251
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 57.4 bits (137), Expect = 2e-08
Identities = 44/156 (28%), Positives = 76/156 (48%), Gaps = 9/156 (5%)
Query: 15 DGISSVKFSPNTSQFLLVSSWDTSVRLYDV-PANSMRLKYQHTGAVLDCAFY-DPTHAWS 72
+ +SSVKFSPN ++L SS D + ++ + Y H + D A+ D + S
Sbjct: 42 EAVSSVKFSPN-GEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVS 100
Query: 73 GGLDHQLKMHDLNTDQ--ENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRT-PC 129
D LK+ D+ + + + L G H + C + P N++++GS+D+TVK+W+ +T C
Sbjct: 101 ASDDKTLKLWDVRSGKCLKTLKG-HSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKC 159
Query: 130 --NAGTFSQPEKVYTLSVSGDRLIVGTAGRRVLVWD 163
S P + SG ++ G+ +WD
Sbjct: 160 LKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195
Score = 43.1 bits (100), Expect = 3e-04
Identities = 41/161 (25%), Positives = 75/161 (46%), Gaps = 11/161 (6%)
Query: 22 FSPNTSQFLLVSSWDTSVRLYDVPANS-MRLKYQHTGAVLDCAFY-DPTHAWSGGLDHQL 79
F+P S ++ S+D +V++++V ++ H+ V F + SG D
Sbjct: 133 FNP-PSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLC 191
Query: 80 KMHDLNTDQ--ENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWD-PRTPCNAGTFSQ 136
++ D + Q + LV + P+ V++ P ++T + D T+KLWD R C
Sbjct: 192 RIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGH 251
Query: 137 PEKVYTL----SVSGDRLIV-GTAGRRVLVWDLRNMGYVQQ 172
+ Y + SV+G + IV G+ V +W+L+ VQ+
Sbjct: 252 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQK 292
Score = 31.6 bits (70), Expect = 1.0
Identities = 33/179 (18%), Positives = 66/179 (36%), Gaps = 27/179 (15%)
Query: 91 LVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFSQPEKVYTLSVS---- 146
LVG H + V++ P + + S D+ + +W G + + + L +S
Sbjct: 37 LVG-HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYD----GKYEKTLYGHNLEISDVAW 91
Query: 147 ---GDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCIRAFPNKQGYVLSSIEGRV 203
RL+ + + + +WD+R+ +C++ YV
Sbjct: 92 SSDSSRLVSASDDKTLKLWDVRS---------------GKCLKTLKGHSNYVFCCNFNPP 136
Query: 204 AVEYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAISFHNIHNTFATGGSDGFVNIWD 262
+ + S + K + K + + PV+A+ F+ + +G DG IWD
Sbjct: 137 SNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195
>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
[Homo sapiens]
Length = 340
Score = 55.8 bits (133), Expect = 5e-08
Identities = 65/280 (23%), Positives = 114/280 (40%), Gaps = 26/280 (9%)
Query: 27 SQFLLVSSWDTSVRLYD-VPANSMRLKYQHTGAVLDCAFYDPT--HAWSGGLDHQLKMHD 83
S+ L+ +S D + ++D N M + V+ CA Y P+ + GGLD+ +++
Sbjct: 67 SRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCA-YAPSGNYVACGGLDNICSIYN 125
Query: 84 LNTDQENLVGTHDAP-----IRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFS-QP 137
L T + N+ + + P + C + + + VT S D T LWD T TF+
Sbjct: 126 LKTREGNVRVSRELPGHTGYLSCCRFLDDSQI-VTSSGDTTCALWDIETAQQTTTFTGHS 184
Query: 138 EKVYTLSVSGDR--LIVGTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCIRAFPNKQGYV 195
V +LS+S D + G +WD+R+ G +Q + + FPN GY
Sbjct: 185 GDVMSLSLSPDMRTFVSGACDASSKLWDIRD-GMCRQSFTGHVS-DINAVSFFPN--GYA 240
Query: 196 LSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAISFHNIHNTFATGGSD 255
++ D + + Y+ +NI I + +++F G D
Sbjct: 241 FATGSDDATCRLFDLRADQELLLYS-------HDNI--ICGITSVAFSKSGRLLLAGYDD 291
Query: 256 GFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIAS 295
N+WD R + ++ L ++DG +A S
Sbjct: 292 FNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGS 331
Score = 46.2 bits (108), Expect = 4e-05
Identities = 32/115 (27%), Positives = 52/115 (45%), Gaps = 10/115 (8%)
Query: 17 ISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVLDCAFYDPTHAWSGGL- 75
I++V F PN F S D + RL+D+ A+ L Y H + C + SG L
Sbjct: 229 INAVSFFPNGYAFATGSD-DATCRLFDLRADQELLLYSHDNII--CGITSVAFSKSGRLL 285
Query: 76 -----DHQLKMHD-LNTDQENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWD 124
D + D L D+ ++ HD + C+ + + TGSWD +++W+
Sbjct: 286 LAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 55.8 bits (133), Expect = 5e-08
Identities = 70/283 (24%), Positives = 116/283 (40%), Gaps = 32/283 (11%)
Query: 27 SQFLLVSSWDTSVRLYD-VPANSMRLKYQHTGAVLDCAFYDPT--HAWSGGLDHQLKMHD 83
S+ L+ +S D + ++D N + + V+ CA Y P+ + GGLD+ +++
Sbjct: 67 SRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCA-YAPSGNYVACGGLDNICSIYN 125
Query: 84 LNTDQENL-----VGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFS-QP 137
L T + N+ + H + C + + N +VT S D T LWD T TF+
Sbjct: 126 LKTREGNVRVSRELAGHTGYLSCCRFLDD-NQIVTSSGDTTCALWDIETGQQTTTFTGHT 184
Query: 138 EKVYTLSVSGD-RLIV-GTAGRRVLVWDLRNMGYVQQR---RESSLKYQTRCIRAFPNKQ 192
V +LS++ D RL V G +WD+R G +Q ES + I FPN
Sbjct: 185 GDVMSLSLAPDTRLFVSGACDASAKLWDVRE-GMCRQTFTGHESDIN----AICFFPNGN 239
Query: 193 GYVLSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAISFHNIHNTFATG 252
+ S + + L E+ + +NI I + ++SF G
Sbjct: 240 AFATGSDDATCRLFDLRADQELMTYSH---------DNI--ICGITSVSFSKSGRLLLAG 288
Query: 253 GSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIAS 295
D N+WD R + ++ L ++DG +A S
Sbjct: 289 YDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGS 331
Score = 49.3 bits (116), Expect = 5e-06
Identities = 32/118 (27%), Positives = 55/118 (46%), Gaps = 10/118 (8%)
Query: 14 EDGISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVLDCAFYDPTHAWSG 73
E I+++ F PN + F S D + RL+D+ A+ + Y H + C + + SG
Sbjct: 226 ESDINAICFFPNGNAFATGSD-DATCRLFDLRADQELMTYSHDNII--CGITSVSFSKSG 282
Query: 74 GL------DHQLKMHD-LNTDQENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWD 124
L D + D L D+ ++ HD + C+ + + TGSWD +K+W+
Sbjct: 283 RLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 55.5 bits (132), Expect = 7e-08
Identities = 31/111 (27%), Positives = 55/111 (49%), Gaps = 4/111 (3%)
Query: 17 ISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVLDCAFYDPTHAW--SGG 74
I S+ F P +F+ S DT+++L+D+ +Y+ + C + P W S
Sbjct: 108 ICSLDFHPY-GEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAA 166
Query: 75 LDHQLKMHDLNTDQE-NLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWD 124
DH +K+ DL + + H P+ VE+ P ++ +GS D+T++ WD
Sbjct: 167 DDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD 217
Score = 48.5 bits (114), Expect = 8e-06
Identities = 55/226 (24%), Positives = 90/226 (39%), Gaps = 23/226 (10%)
Query: 72 SGGLDHQLKMHDLNTDQ--ENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPC 129
+GG D ++ + +N +L G H +P+ V ++V GS ++++WD
Sbjct: 38 TGGDDCRVNLWSINKPNCIMSLTG-HTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAK 96
Query: 130 NAGTFSQPEKVYTLSVS----GDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCI 185
T K S+ G+ + G+ + +WD+R G V + R S RC+
Sbjct: 97 ILRTL-MGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHS--QAVRCL 153
Query: 186 RAFPNKQGYVLSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAISFHNI 245
R P+ G L+S V+ D + K F H PVN + FH
Sbjct: 154 RFSPD--GKWLASAADDHTVKLWDLT--AGKMMSEFPGHT---------GPVNVVEFHPN 200
Query: 246 HNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTL 291
A+G SD + WD + + P + S+ F+ DG L
Sbjct: 201 EYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCL 246
Score = 32.0 bits (71), Expect = 0.77
Identities = 16/57 (28%), Positives = 28/57 (49%)
Query: 239 AISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIAS 295
++ FH A+G D + +WD K + ++ + ++ L FS DG LA A+
Sbjct: 110 SLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAA 166
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 54.7 bits (130), Expect = 1e-07
Identities = 65/261 (24%), Positives = 106/261 (40%), Gaps = 39/261 (14%)
Query: 15 DGISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQ-HTGAVLDCAFYD-PTHAWS 72
D +S F P+ + L SS DT+V+L+D+ L ++ H+ AV C ++ S
Sbjct: 395 DWLSDCCFHPSGDK-LATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVAS 453
Query: 73 GGLDHQLKMHDLNTDQEN--LVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTP-C 129
LD K+ D+N+++ L G H + +E+ P N ++T S D+T+ +WD RT C
Sbjct: 454 SSLDKTSKIWDVNSERCRCTLYG-HTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGIC 512
Query: 130 NAGTFSQPEKV--YTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCIRA 187
+ + G + A +WD R + L + I
Sbjct: 513 EQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKL----------LPIVSIDIGP 562
Query: 188 FPNKQ------GYVLSSIEGRVAVEYLD-PSPEVQKKKYAFKCHRLKENNIEQIYPVNAI 240
P + G VL+ G + LD S E+ H+L + E + +
Sbjct: 563 SPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEI---------HKLMGHENE----AHTV 609
Query: 241 SFHNIHNTFATGGSDGFVNIW 261
F + +GGSDG V W
Sbjct: 610 VFSHDGEILFSGGSDGTVRTW 630
Score = 35.4 bits (80), Expect = 0.070
Identities = 41/181 (22%), Positives = 67/181 (37%), Gaps = 26/181 (14%)
Query: 89 ENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWD-PRTPCNAGTFSQPEKVYTLSV-- 145
+N+ H+ P+ CV P +++V+ D+ K+ P+ F + +
Sbjct: 345 KNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHP 404
Query: 146 SGDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCIRAFPNKQGYVLS----SIEG 201
SGD+L + V +WDL + CI F V S S
Sbjct: 405 SGDKLATSSGDTTVKLWDL---------------CKGDCILTFEGHSRAVWSCTWHSCGN 449
Query: 202 RVAVEYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAISFHNIHNTFATGGSDGFVNIW 261
VA LD + ++ + R + VN+I F NT T +D ++IW
Sbjct: 450 FVASSSLDKTSKI----WDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIW 505
Query: 262 D 262
D
Sbjct: 506 D 506
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 53.9 bits (128), Expect = 2e-07
Identities = 60/277 (21%), Positives = 102/277 (36%), Gaps = 41/277 (14%)
Query: 36 DTSVRLYDVPANSMRLKYQHTGAVLDCAFYDPTHAW--SGGLDHQLKMHDLNTDQENLV- 92
D+ + ++ + S ++ + C + P+ SG D +++ N E+ V
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 93 GTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFSQP---EKVYTLSVSGDR 149
H A +R V +C + VT S D+TVK+W + SQ + S G
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
Query: 150 LIVGTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCIRAFPNKQGYVLSSIEGRVAVEYLD 209
++ + + V +WD K C+ ++ G+V Y+D
Sbjct: 122 IVSASDDKTVKLWD---------------KSSRECVHSYCEHGGFVT----------YVD 156
Query: 210 PSP----------EVQKKKYAFKCHRLKENNIEQIYPVNAISFHNIHNTFATGGSDGFVN 259
P + K + + HRL ++ VN +SFH N T SD +
Sbjct: 157 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLK 216
Query: 260 IWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASS 296
I D + L H + ++AFS G A S
Sbjct: 217 ILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGS 253
>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
isoform a [Homo sapiens]
Length = 353
Score = 53.5 bits (127), Expect = 2e-07
Identities = 41/158 (25%), Positives = 71/158 (44%), Gaps = 11/158 (6%)
Query: 17 ISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVLDCAFYDPTHAW----S 72
+S+ F+ N+ +L +S D + L+DV + + + GA + C P+ S
Sbjct: 156 LSACSFT-NSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVS 214
Query: 73 GGLDHQLKMHDLNTDQ-ENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNA 131
GG D + + D+ + Q TH++ I V Y P + +GS D T +L+D R
Sbjct: 215 GGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREV 274
Query: 132 GTFSQPEKVY-----TLSVSGDRLIVGTAGRRVLVWDL 164
+S+ ++ S+SG L G + VWD+
Sbjct: 275 AIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDV 312
Score = 46.2 bits (108), Expect = 4e-05
Identities = 57/252 (22%), Positives = 101/252 (40%), Gaps = 30/252 (11%)
Query: 59 VLDCAFYDPTHAWS-GGLDHQLKMHDLNTDQ-ENL------VGTHDAPIRCVEYCPEVNV 110
V+ CA+ A + GGLD++ ++ L D+ EN+ V H + +
Sbjct: 108 VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQ 167
Query: 111 MVTGSWDQTVKLWDPRTPCNAGTF-SQPEKVYTL----SVSGDRLIVGTAGRRVLVWDLR 165
++T S D T LWD + +F V L S +G+ + G ++ +VWD+R
Sbjct: 168 ILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMR 227
Query: 166 NMGYVQ--QRRESSLKYQTRCIRAFPNKQGYVLSSIEGRVAVEYLDPSPEVQKKKYAFKC 223
+ VQ + ES + +R +P+ + S + + L EV
Sbjct: 228 SGQCVQAFETHESDIN----SVRYYPSGDAFASGSDDATCRLYDLRADREVAIYS----- 278
Query: 224 HRLKENNIEQIYPVNAISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLA 283
KE+ I + +++ F G +D +N+WD R+ + +++L
Sbjct: 279 ---KESII---FGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLR 332
Query: 284 FSNDGTTLAIAS 295
S DGT S
Sbjct: 333 VSPDGTAFCSGS 344
Score = 40.0 bits (92), Expect = 0.003
Identities = 27/115 (23%), Positives = 55/115 (47%), Gaps = 6/115 (5%)
Query: 14 EDGISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVLDCAFYDPTHA--- 70
E I+SV++ P+ F S D + RLYD+ A+ Y + + D + +
Sbjct: 239 ESDINSVRYYPSGDAFASGSD-DATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRL 297
Query: 71 -WSGGLDHQLKMHD-LNTDQENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLW 123
++G D+ + + D L + +++ H+ + + P+ +GSWD T+++W
Sbjct: 298 LFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
isoform b [Homo sapiens]
Length = 395
Score = 53.5 bits (127), Expect = 2e-07
Identities = 41/158 (25%), Positives = 71/158 (44%), Gaps = 11/158 (6%)
Query: 17 ISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVLDCAFYDPTHAW----S 72
+S+ F+ N+ +L +S D + L+DV + + + GA + C P+ S
Sbjct: 198 LSACSFT-NSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVS 256
Query: 73 GGLDHQLKMHDLNTDQ-ENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNA 131
GG D + + D+ + Q TH++ I V Y P + +GS D T +L+D R
Sbjct: 257 GGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREV 316
Query: 132 GTFSQPEKVY-----TLSVSGDRLIVGTAGRRVLVWDL 164
+S+ ++ S+SG L G + VWD+
Sbjct: 317 AIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDV 354
Score = 46.2 bits (108), Expect = 4e-05
Identities = 57/252 (22%), Positives = 101/252 (40%), Gaps = 30/252 (11%)
Query: 59 VLDCAFYDPTHAWS-GGLDHQLKMHDLNTDQ-ENL------VGTHDAPIRCVEYCPEVNV 110
V+ CA+ A + GGLD++ ++ L D+ EN+ V H + +
Sbjct: 150 VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQ 209
Query: 111 MVTGSWDQTVKLWDPRTPCNAGTF-SQPEKVYTL----SVSGDRLIVGTAGRRVLVWDLR 165
++T S D T LWD + +F V L S +G+ + G ++ +VWD+R
Sbjct: 210 ILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMR 269
Query: 166 NMGYVQ--QRRESSLKYQTRCIRAFPNKQGYVLSSIEGRVAVEYLDPSPEVQKKKYAFKC 223
+ VQ + ES + +R +P+ + S + + L EV
Sbjct: 270 SGQCVQAFETHESDIN----SVRYYPSGDAFASGSDDATCRLYDLRADREVAIYS----- 320
Query: 224 HRLKENNIEQIYPVNAISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLA 283
KE+ I + +++ F G +D +N+WD R+ + +++L
Sbjct: 321 ---KESII---FGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLR 374
Query: 284 FSNDGTTLAIAS 295
S DGT S
Sbjct: 375 VSPDGTAFCSGS 386
Score = 40.0 bits (92), Expect = 0.003
Identities = 27/115 (23%), Positives = 55/115 (47%), Gaps = 6/115 (5%)
Query: 14 EDGISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVLDCAFYDPTHA--- 70
E I+SV++ P+ F S D + RLYD+ A+ Y + + D + +
Sbjct: 281 ESDINSVRYYPSGDAFASGSD-DATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRL 339
Query: 71 -WSGGLDHQLKMHD-LNTDQENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLW 123
++G D+ + + D L + +++ H+ + + P+ +GSWD T+++W
Sbjct: 340 LFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 53.5 bits (127), Expect = 2e-07
Identities = 59/282 (20%), Positives = 105/282 (37%), Gaps = 22/282 (7%)
Query: 17 ISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVLDCAFYDPTHAWSGGLD 76
I+S+ SPN Q L +SWDT + L++ ++ +Y V+ + P
Sbjct: 21 ITSLDLSPNGKQ-LATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASAS 79
Query: 77 HQLKMHDLNTDQENLVG---THDAPIRCVEYCPEVNVMVTGSWDQTVKLWDP-RTPCNAG 132
+ D+ H AP+R V++ + + T S D+++K+W R
Sbjct: 80 RDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYS 139
Query: 133 TFSQPEKVYTLSVSGD-RLIVGTA-GRRVLVWDLRNMGYVQQRRESSLKYQTRCIRAFPN 190
+ V S D RLIV + + + +WD N +C+ F +
Sbjct: 140 LYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNK---------------QCVNNFSD 184
Query: 191 KQGYVLSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAISFHNIHNTFA 250
G+ + K + + ++L ++ VN ISFH N
Sbjct: 185 SVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLI 244
Query: 251 TGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLA 292
T SDG + I D + + + + +++FS G A
Sbjct: 245 TASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFA 286
Score = 51.6 bits (122), Expect = 9e-07
Identities = 60/254 (23%), Positives = 106/254 (41%), Gaps = 22/254 (8%)
Query: 14 EDGISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQ-HTGAVLDCAFY-DPTHAW 71
+D ++SV+FSP+ L +S D +VRL+ +++ HT V F D
Sbjct: 60 KDVVTSVQFSPH-GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLA 118
Query: 72 SGGLDHQLKMHDLNTDQENL-VGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCN 130
+ D +K+ + + + H +RC ++ P+ ++V+ S D+T+K+WD
Sbjct: 119 TASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQC 178
Query: 131 AGTFSQP---EKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCIRA 187
FS + SG + + + V VWD+R +Q + S CI
Sbjct: 179 VNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHS--GGVNCISF 236
Query: 188 FPNKQGYVLSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAISFHNIHN 247
P+ + +S +G + + L + Y + H PV +SF
Sbjct: 237 HPSGNYLITASSDGTLKILDLLEGRLI----YTLQGH---------TGPVFTVSFSKGGE 283
Query: 248 TFATGGSDGFVNIW 261
FA+GG+D V +W
Sbjct: 284 LFASGGADTQVLLW 297
Score = 35.8 bits (81), Expect = 0.054
Identities = 27/104 (25%), Positives = 42/104 (40%), Gaps = 10/104 (9%)
Query: 202 RVAVEYLDPSPEVQKKKYA----------FKCHRLKENNIEQIYPVNAISFHNIHNTFAT 251
+ A+ LD SP ++ A FK H + V ++ F N A+
Sbjct: 18 KAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLAS 77
Query: 252 GGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIAS 295
D V +W P + + +F + + S+ FS DG LA AS
Sbjct: 78 ASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATAS 121
Score = 34.7 bits (78), Expect = 0.12
Identities = 40/204 (19%), Positives = 64/204 (31%), Gaps = 60/204 (29%)
Query: 95 HDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFSQPEKVYT---LSVSGDRLI 151
H A I ++ P + T SWD + LW+ + A + + V T S G+ L
Sbjct: 17 HKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLA 76
Query: 152 VGTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCIRAFPNKQGYVLSSIEGRVAVEYLDPS 211
+ R V +W P+K+G
Sbjct: 77 SASRDRTVRLW-------------------------IPDKRG------------------ 93
Query: 212 PEVQKKKYAFKCHRLKENNIEQIYPVNAISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQ 271
K FK H PV ++ F AT D + +W + ++ L
Sbjct: 94 -----KFSEFKAHTA---------PVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYS 139
Query: 272 FHRYPTSIASLAFSNDGTTLAIAS 295
+R+ + FS DG + S
Sbjct: 140 LYRHTHWVRCAKFSPDGRLIVSCS 163
>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
[Homo sapiens]
Length = 340
Score = 52.4 bits (124), Expect = 6e-07
Identities = 62/282 (21%), Positives = 116/282 (41%), Gaps = 30/282 (10%)
Query: 27 SQFLLVSSWDTSVRLYD-VPANSMRLKYQHTGAVLDCAFYDPTHAW--SGGLDHQLKMHD 83
S+ L+ +S D + ++D N + + V+ CA Y P+ + GGLD+ ++
Sbjct: 67 SRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCA-YAPSGNFVACGGLDNICSIYS 125
Query: 84 LNTDQENLVGTHDAP-----IRCVEYCPEVNVMVTGSWDQTVKLWDPRT-PCNAGTFSQP 137
L T + N+ + + P + C + + N ++T S D T LWD T G
Sbjct: 126 LKTREGNVRVSRELPGHTGYLSCCRFLDD-NQIITSSGDTTCALWDIETGQQTVGFAGHS 184
Query: 138 EKVYTLSVSGD--RLIVGTAGRRVLVWDLRNMGYVQQRRESSLKYQT--RCIRAFPNKQG 193
V +LS++ D + G + +WD+R+ R++ + +++ + FPN G
Sbjct: 185 GDVMSLSLAPDGRTFVSGACDASIKLWDVRD----SMCRQTFIGHESDINAVAFFPN--G 238
Query: 194 YVLSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAISFHNIHNTFATGG 253
Y ++ D + + Y+ +NI I + +++F G
Sbjct: 239 YAFTTGSDDATCRLFDLRADQELLMYS-------HDNI--ICGITSVAFSRSGRLLLAGY 289
Query: 254 SDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIAS 295
D NIWD R + ++ L ++DG +A S
Sbjct: 290 DDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGS 331
Score = 48.1 bits (113), Expect = 1e-05
Identities = 33/118 (27%), Positives = 53/118 (44%), Gaps = 10/118 (8%)
Query: 14 EDGISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVLDCAFYDPTHAWSG 73
E I++V F PN F S D + RL+D+ A+ L Y H + C + SG
Sbjct: 226 ESDINAVAFFPNGYAFTTGSD-DATCRLFDLRADQELLMYSHDNII--CGITSVAFSRSG 282
Query: 74 GL------DHQLKMHD-LNTDQENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWD 124
L D + D + D+ ++ HD + C+ + + TGSWD +K+W+
Sbjct: 283 RLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
>gi|217330644 WD repeat domain 12 protein [Homo sapiens]
Length = 423
Score = 51.6 bits (122), Expect = 9e-07
Identities = 43/145 (29%), Positives = 73/145 (50%), Gaps = 20/145 (13%)
Query: 15 DGISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTG-AVLDCAFYDP--THAW 71
+ +SSV +S ++ + +SWD ++R++DV + S LK TG V +C Y P
Sbjct: 258 EAVSSVLWSD--AEEICSASWDHTIRVWDVESGS--LKSTLTGNKVFNCISYSPLCKRLA 313
Query: 72 SGGLDHQLKMHDLNTDQENLVG----THDAPIRCVEYCP-EVNVMVTGSWDQTVKLWDPR 126
SG D +++ D T +LV +H + V++ P +++GS D VKLWD R
Sbjct: 314 SGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDTR 373
Query: 127 TPCNAGTFSQPEKVYTLSVSGDRLI 151
+ C A +Y L+ D+++
Sbjct: 374 S-CKA-------PLYDLAAHEDKVL 390
Score = 44.7 bits (104), Expect = 1e-04
Identities = 31/119 (26%), Positives = 51/119 (42%), Gaps = 7/119 (5%)
Query: 55 HTGAVLDCAFYDPTHAWSGGLDHQLKMHDLNTDQENLVGTHDAPIRCVEYCPEVNVMVTG 114
H AV + D S DH +++ D+ + T + C+ Y P + +G
Sbjct: 256 HMEAVSSVLWSDAEEICSASWDHTIRVWDVESGSLKSTLTGNKVFNCISYSPLCKRLASG 315
Query: 115 SWDQTVKLWDPRTP----CNAGTFSQPEKVYTLSVS---GDRLIVGTAGRRVLVWDLRN 166
S D+ ++LWDPRT + S V ++ S +LI G+ V +WD R+
Sbjct: 316 STDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDTRS 374
Score = 36.2 bits (82), Expect = 0.041
Identities = 25/119 (21%), Positives = 50/119 (42%), Gaps = 12/119 (10%)
Query: 14 EDGISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVLDCAFYDPTH---- 69
+D ISS+K +++L S+D + R++ + S+ HT V D A+
Sbjct: 101 DDWISSIK---GAEEWILTGSYDKTSRIWSLEGKSIMTIVGHTDVVKDVAWVKKDSLSCL 157
Query: 70 AWSGGLDHQLKMHDLNTDQENLVGT-----HDAPIRCVEYCPEVNVMVTGSWDQTVKLW 123
S +D + + + N ++ + H + + +GSWD+ +K+W
Sbjct: 158 LLSASMDQTILLWEWNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIW 216
Score = 31.2 bits (69), Expect = 1.3
Identities = 22/65 (33%), Positives = 32/65 (49%), Gaps = 2/65 (3%)
Query: 17 ISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRL--KYQHTGAVLDCAFYDPTHAWSGG 74
++SVK+SP Q L+ S D V+L+D + L H VL + D SGG
Sbjct: 345 VTSVKWSPTHEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGG 404
Query: 75 LDHQL 79
D++L
Sbjct: 405 ADNKL 409
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 50.4 bits (119), Expect = 2e-06
Identities = 33/115 (28%), Positives = 56/115 (48%), Gaps = 4/115 (3%)
Query: 62 CAFYDPTHAWSGGLDHQLKMHDLNT-DQENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTV 120
C YD SG D+ +K+ D NT + + ++ H + C++Y + V++TGS D TV
Sbjct: 272 CLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTV 329
Query: 121 KLWDPRTPCNAGT-FSQPEKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRR 174
++WD T T E V L + ++ + R + VWD+ + + RR
Sbjct: 330 RVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRR 384
Score = 38.9 bits (89), Expect = 0.006
Identities = 47/183 (25%), Positives = 85/183 (46%), Gaps = 15/183 (8%)
Query: 30 LLVSSWDTSVRLYDVPANSM-RLKYQHTGAVLDCAFYDPTHAWSGGLDHQLKMHDLN--- 85
++ S D++VR++DV M H AVL F + + D + + D+
Sbjct: 320 IITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMV-TCSKDRSIAVWDMASPT 378
Query: 86 --TDQENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFSQPEKVYTL 143
T + LVG H A + V++ + +V+ S D+T+K+W+ T T + ++
Sbjct: 379 DITLRRVLVG-HRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIAC 435
Query: 144 SVSGDRLIV-GTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCIRAFPNKQGYVLSSIEGR 202
DRL+V G++ + +WD+ + R + RCIR F NK+ V + +G+
Sbjct: 436 LQYRDRLVVSGSSDNTIRLWDIECGACL--RVLEGHEELVRCIR-FDNKR-IVSGAYDGK 491
Query: 203 VAV 205
+ V
Sbjct: 492 IKV 494
Score = 29.3 bits (64), Expect = 5.0
Identities = 30/127 (23%), Positives = 54/127 (42%), Gaps = 24/127 (18%)
Query: 30 LLVS-SWDTSVRLYDVPANSMRLKYQHTGAVLDCAFYDPTHAWSGGLDHQLKMHDL--NT 86
L+VS S D ++RL+D+ + + ++ C +D SG D ++K+ DL
Sbjct: 442 LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAAL 501
Query: 87 DQENLVGT--------HDAPIRCVEYCPEVNVMVTGSWDQTVKLWD-----------PRT 127
D GT H + +++ + +V+ S D T+ +WD PR+
Sbjct: 502 DPRAPAGTLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWDFLNDPAAQAEPPRS 559
Query: 128 PCNAGTF 134
P T+
Sbjct: 560 PSRTYTY 566
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 50.4 bits (119), Expect = 2e-06
Identities = 33/115 (28%), Positives = 56/115 (48%), Gaps = 4/115 (3%)
Query: 62 CAFYDPTHAWSGGLDHQLKMHDLNT-DQENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTV 120
C YD SG D+ +K+ D NT + + ++ H + C++Y + V++TGS D TV
Sbjct: 308 CLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTV 365
Query: 121 KLWDPRTPCNAGT-FSQPEKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRR 174
++WD T T E V L + ++ + R + VWD+ + + RR
Sbjct: 366 RVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRR 420
Score = 38.9 bits (89), Expect = 0.006
Identities = 47/183 (25%), Positives = 85/183 (46%), Gaps = 15/183 (8%)
Query: 30 LLVSSWDTSVRLYDVPANSM-RLKYQHTGAVLDCAFYDPTHAWSGGLDHQLKMHDLN--- 85
++ S D++VR++DV M H AVL F + + D + + D+
Sbjct: 356 IITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMV-TCSKDRSIAVWDMASPT 414
Query: 86 --TDQENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFSQPEKVYTL 143
T + LVG H A + V++ + +V+ S D+T+K+W+ T T + ++
Sbjct: 415 DITLRRVLVG-HRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIAC 471
Query: 144 SVSGDRLIV-GTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCIRAFPNKQGYVLSSIEGR 202
DRL+V G++ + +WD+ + R + RCIR F NK+ V + +G+
Sbjct: 472 LQYRDRLVVSGSSDNTIRLWDIECGACL--RVLEGHEELVRCIR-FDNKR-IVSGAYDGK 527
Query: 203 VAV 205
+ V
Sbjct: 528 IKV 530
Score = 29.3 bits (64), Expect = 5.0
Identities = 30/127 (23%), Positives = 54/127 (42%), Gaps = 24/127 (18%)
Query: 30 LLVS-SWDTSVRLYDVPANSMRLKYQHTGAVLDCAFYDPTHAWSGGLDHQLKMHDL--NT 86
L+VS S D ++RL+D+ + + ++ C +D SG D ++K+ DL
Sbjct: 478 LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAAL 537
Query: 87 DQENLVGT--------HDAPIRCVEYCPEVNVMVTGSWDQTVKLWD-----------PRT 127
D GT H + +++ + +V+ S D T+ +WD PR+
Sbjct: 538 DPRAPAGTLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWDFLNDPAAQAEPPRS 595
Query: 128 PCNAGTF 134
P T+
Sbjct: 596 PSRTYTY 602
>gi|14150171 THO complex 3 [Homo sapiens]
Length = 351
Score = 50.4 bits (119), Expect = 2e-06
Identities = 55/231 (23%), Positives = 93/231 (40%), Gaps = 24/231 (10%)
Query: 72 SGGLDHQLKMHDLNTD----QENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRT 127
SG D + L D + N G D+ + + ++ VT S D+T+++WD RT
Sbjct: 72 SGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSNPDLFVTASGDKTIRIWDVRT 131
Query: 128 P-CNAGTFSQPEKVYTL-SVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCI 185
C A ++ E + S G + VG V D + + + E K++ I
Sbjct: 132 TKCIATVNTKGENINICWSPDGQTIAVGNKDDVVTFIDAKTH---RSKAEEQFKFEVNEI 188
Query: 186 RAFPNKQGYVLSSIEGRVAV-EYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAISFHN 244
+ + L++ G + + Y + P + C +K F
Sbjct: 189 SWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSNCICIK--------------FDP 234
Query: 245 IHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIAS 295
+ FATG +D V++WD + F R + +L+FS+DG LA AS
Sbjct: 235 MGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDGKMLASAS 285
>gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]
Length = 425
Score = 50.1 bits (118), Expect = 3e-06
Identities = 49/177 (27%), Positives = 85/177 (48%), Gaps = 20/177 (11%)
Query: 20 VKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQ--------HTGAVLDCAFYDPTHAW 71
+ ++ N S LL +S D +V L+D+ A K H+ V D A++ +
Sbjct: 182 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 241
Query: 72 SGGL--DHQLKMHDLNTDQ----ENLVGTHDAPIRCVEYCPEVN-VMVTGSWDQTVKLWD 124
G + D +L + D ++ +LV H A + C+ + P ++ TGS D+TV LWD
Sbjct: 242 FGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 301
Query: 125 PRT-PCNAGTF-SQPEKVYTLSVS-GDRLIVGTAG--RRVLVWDLRNMGYVQQRRES 176
R TF S ++++ + S + I+ ++G RR+ VWDL +G Q ++
Sbjct: 302 LRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDA 358
>gi|207029439 retinoblastoma binding protein 4 isoform c [Homo
sapiens]
Length = 390
Score = 49.7 bits (117), Expect = 4e-06
Identities = 46/177 (25%), Positives = 84/177 (47%), Gaps = 20/177 (11%)
Query: 20 VKFSPNTSQFLLVSSWDTSVRLYDVPA--------NSMRLKYQHTGAVLDCAFYDPTHAW 71
+ ++PN S LL +S D ++ L+D+ A ++ + HT V D +++ +
Sbjct: 148 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 207
Query: 72 SGGLDHQLKMHDLNTDQENL------VGTHDAPIRCVEYCPEVN-VMVTGSWDQTVKLWD 124
G + K+ +T N V H A + C+ + P ++ TGS D+TV LWD
Sbjct: 208 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 267
Query: 125 PRT-PCNAGTF-SQPEKVYTLSVS-GDRLIVGTAG--RRVLVWDLRNMGYVQQRRES 176
R +F S ++++ + S + I+ ++G RR+ VWDL +G Q ++
Sbjct: 268 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDA 324
>gi|207029415 retinoblastoma binding protein 4 isoform b [Homo
sapiens]
Length = 424
Score = 49.7 bits (117), Expect = 4e-06
Identities = 46/177 (25%), Positives = 84/177 (47%), Gaps = 20/177 (11%)
Query: 20 VKFSPNTSQFLLVSSWDTSVRLYDVPA--------NSMRLKYQHTGAVLDCAFYDPTHAW 71
+ ++PN S LL +S D ++ L+D+ A ++ + HT V D +++ +
Sbjct: 182 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 241
Query: 72 SGGLDHQLKMHDLNTDQENL------VGTHDAPIRCVEYCPEVN-VMVTGSWDQTVKLWD 124
G + K+ +T N V H A + C+ + P ++ TGS D+TV LWD
Sbjct: 242 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 301
Query: 125 PRT-PCNAGTF-SQPEKVYTLSVS-GDRLIVGTAG--RRVLVWDLRNMGYVQQRRES 176
R +F S ++++ + S + I+ ++G RR+ VWDL +G Q ++
Sbjct: 302 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDA 358
>gi|5032027 retinoblastoma binding protein 4 isoform a [Homo
sapiens]
Length = 425
Score = 49.7 bits (117), Expect = 4e-06
Identities = 46/177 (25%), Positives = 84/177 (47%), Gaps = 20/177 (11%)
Query: 20 VKFSPNTSQFLLVSSWDTSVRLYDVPA--------NSMRLKYQHTGAVLDCAFYDPTHAW 71
+ ++PN S LL +S D ++ L+D+ A ++ + HT V D +++ +
Sbjct: 183 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 242
Query: 72 SGGLDHQLKMHDLNTDQENL------VGTHDAPIRCVEYCPEVN-VMVTGSWDQTVKLWD 124
G + K+ +T N V H A + C+ + P ++ TGS D+TV LWD
Sbjct: 243 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 302
Query: 125 PRT-PCNAGTF-SQPEKVYTLSVS-GDRLIVGTAG--RRVLVWDLRNMGYVQQRRES 176
R +F S ++++ + S + I+ ++G RR+ VWDL +G Q ++
Sbjct: 303 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDA 359
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 49.3 bits (116), Expect = 5e-06
Identities = 40/154 (25%), Positives = 74/154 (48%), Gaps = 9/154 (5%)
Query: 17 ISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQ-HTGAVLDCAFYDPTHAW-SGG 74
+SSVKFSPN ++L SS D ++++ H + D A+ ++ S
Sbjct: 48 VSSVKFSPN-GEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSAS 106
Query: 75 LDHQLKMHDLNTDQ--ENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAG 132
D LK+ D+++ + + L G H + C + P+ N++V+GS+D++V++WD +T
Sbjct: 107 DDKTLKIWDVSSGKCLKTLKG-HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK 165
Query: 133 TF---SQPEKVYTLSVSGDRLIVGTAGRRVLVWD 163
T S P + G ++ + +WD
Sbjct: 166 TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Score = 43.5 bits (101), Expect = 3e-04
Identities = 41/161 (25%), Positives = 74/161 (45%), Gaps = 11/161 (6%)
Query: 22 FSPNTSQFLLVSSWDTSVRLYDVPANS-MRLKYQHTGAVLDCAFY-DPTHAWSGGLDHQL 79
F+P S ++ S+D SVR++DV ++ H+ V F D + S D
Sbjct: 137 FNPQ-SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 195
Query: 80 KMHDLNTDQ--ENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWD-PRTPCNAGTFSQ 136
++ D + Q + L+ + P+ V++ P ++ + D T+KLWD + C
Sbjct: 196 RIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH 255
Query: 137 PEKVYTL----SVSGDRLIV-GTAGRRVLVWDLRNMGYVQQ 172
+ Y + SV+G + IV G+ V +W+L+ VQ+
Sbjct: 256 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQK 296
Score = 30.0 bits (66), Expect = 2.9
Identities = 20/76 (26%), Positives = 36/76 (47%), Gaps = 4/76 (5%)
Query: 222 KCHRLKENNIEQIYPVNAISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIAS 281
KC + + + ++ N F+ N +G D V IWD K L + +++
Sbjct: 120 KCLKTLKGHSNYVFCCN---FNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSA 176
Query: 282 LAFSNDGTTLAIASSY 297
+ F+ DG +L ++SSY
Sbjct: 177 VHFNRDG-SLIVSSSY 191
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 49.3 bits (116), Expect = 5e-06
Identities = 40/154 (25%), Positives = 74/154 (48%), Gaps = 9/154 (5%)
Query: 17 ISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQ-HTGAVLDCAFYDPTHAW-SGG 74
+SSVKFSPN ++L SS D ++++ H + D A+ ++ S
Sbjct: 48 VSSVKFSPN-GEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSAS 106
Query: 75 LDHQLKMHDLNTDQ--ENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAG 132
D LK+ D+++ + + L G H + C + P+ N++V+GS+D++V++WD +T
Sbjct: 107 DDKTLKIWDVSSGKCLKTLKG-HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK 165
Query: 133 TF---SQPEKVYTLSVSGDRLIVGTAGRRVLVWD 163
T S P + G ++ + +WD
Sbjct: 166 TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Score = 43.5 bits (101), Expect = 3e-04
Identities = 41/161 (25%), Positives = 74/161 (45%), Gaps = 11/161 (6%)
Query: 22 FSPNTSQFLLVSSWDTSVRLYDVPANS-MRLKYQHTGAVLDCAFY-DPTHAWSGGLDHQL 79
F+P S ++ S+D SVR++DV ++ H+ V F D + S D
Sbjct: 137 FNPQ-SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 195
Query: 80 KMHDLNTDQ--ENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWD-PRTPCNAGTFSQ 136
++ D + Q + L+ + P+ V++ P ++ + D T+KLWD + C
Sbjct: 196 RIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH 255
Query: 137 PEKVYTL----SVSGDRLIV-GTAGRRVLVWDLRNMGYVQQ 172
+ Y + SV+G + IV G+ V +W+L+ VQ+
Sbjct: 256 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQK 296
Score = 30.0 bits (66), Expect = 2.9
Identities = 20/76 (26%), Positives = 36/76 (47%), Gaps = 4/76 (5%)
Query: 222 KCHRLKENNIEQIYPVNAISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIAS 281
KC + + + ++ N F+ N +G D V IWD K L + +++
Sbjct: 120 KCLKTLKGHSNYVFCCN---FNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSA 176
Query: 282 LAFSNDGTTLAIASSY 297
+ F+ DG +L ++SSY
Sbjct: 177 VHFNRDG-SLIVSSSY 191
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,366,751
Number of Sequences: 37866
Number of extensions: 575050
Number of successful extensions: 2371
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 126
Number of HSP's successfully gapped in prelim test: 98
Number of HSP's that attempted gapping in prelim test: 1326
Number of HSP's gapped (non-prelim): 846
length of query: 328
length of database: 18,247,518
effective HSP length: 103
effective length of query: 225
effective length of database: 14,347,320
effective search space: 3228147000
effective search space used: 3228147000
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.