Search of human proteins with 47578105

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|47578105 delangin isoform A [Homo sapiens]
         (2804 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|47578105 delangin isoform A [Homo sapiens]                        5540   0.0  
gi|47578107 delangin isoform B [Homo sapiens]                        5306   0.0  
gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]         100   3e-20
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        99   6e-20
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     87   2e-16
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap...    82   1e-14
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap...    82   1e-14
gi|87299628 biorientation of chromosomes in cell division 1-like...    81   1e-14
gi|42560244 peptidylprolyl isomerase G [Homo sapiens]                  81   1e-14
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]       80   2e-14
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]        79   5e-14
gi|6631100 natural killer-tumor recognition sequence [Homo sapiens]    78   1e-13
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]     77   3e-13
gi|217330641 IWS1 homolog [Homo sapiens]                               74   2e-12
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1...    74   3e-12
gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]                    73   3e-12
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]    73   5e-12
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]    73   5e-12
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ...    73   5e-12
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [...    73   5e-12
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ...    72   6e-12
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    72   6e-12
gi|104526627 triadin [Homo sapiens]                                    72   8e-12
gi|148746195 trichohyalin [Homo sapiens]                               72   1e-11
gi|150170670 piccolo isoform 2 [Homo sapiens]                          72   1e-11
gi|150378539 piccolo isoform 1 [Homo sapiens]                          72   1e-11
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]         69   9e-11
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]         69   9e-11
gi|117676384 splicing factor, arginine/serine-rich 2, interactin...    68   1e-10
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                       68   1e-10

>gi|47578105 delangin isoform A [Homo sapiens]
          Length = 2804

 Score = 5540 bits (14371), Expect = 0.0
 Identities = 2804/2804 (100%), Positives = 2804/2804 (100%)

Query: 1    MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDN 60
            MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDN
Sbjct: 1    MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDN 60

Query: 61   LVSQLVHSLNQVSTDHIELKDNLGSDDPEGDIPVLLQAVLARSPNVFREKSMQNRYVQSG 120
            LVSQLVHSLNQVSTDHIELKDNLGSDDPEGDIPVLLQAVLARSPNVFREKSMQNRYVQSG
Sbjct: 61   LVSQLVHSLNQVSTDHIELKDNLGSDDPEGDIPVLLQAVLARSPNVFREKSMQNRYVQSG 120

Query: 121  MMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP 180
            MMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
Sbjct: 121  MMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP 180

Query: 181  QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPR 240
            QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPR
Sbjct: 181  QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPR 240

Query: 241  HGSSEDYLHMVHRLSSDDGDSSTMRNAASFPLRSPQPVCSPAGSEGTPKGSRPPLILQSQ 300
            HGSSEDYLHMVHRLSSDDGDSSTMRNAASFPLRSPQPVCSPAGSEGTPKGSRPPLILQSQ
Sbjct: 241  HGSSEDYLHMVHRLSSDDGDSSTMRNAASFPLRSPQPVCSPAGSEGTPKGSRPPLILQSQ 300

Query: 301  SLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTL 360
            SLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTL
Sbjct: 301  SLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTL 360

Query: 361  RLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCL 420
            RLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCL
Sbjct: 361  RLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCL 420

Query: 421  SQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERI 480
            SQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERI
Sbjct: 421  SQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERI 480

Query: 481  ERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM 540
            ERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM
Sbjct: 481  ERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM 540

Query: 541  VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETP 600
            VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETP
Sbjct: 541  VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETP 600

Query: 601  KKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTE 660
            KKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTE
Sbjct: 601  KKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTE 660

Query: 661  CKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG 720
            CKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG
Sbjct: 661  CKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG 720

Query: 721  HPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVS 780
            HPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVS
Sbjct: 721  HPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVS 780

Query: 781  KHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRV 840
            KHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRV
Sbjct: 781  KHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRV 840

Query: 841  RRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS 900
            RRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS
Sbjct: 841  RRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS 900

Query: 901  NKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPK 960
            NKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPK
Sbjct: 901  NKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPK 960

Query: 961  IKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDR 1020
            IKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDR
Sbjct: 961  IKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDR 1020

Query: 1021 EDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVN 1080
            EDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVN
Sbjct: 1021 EDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVN 1080

Query: 1081 EKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRS 1140
            EKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRS
Sbjct: 1081 EKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRS 1140

Query: 1141 SGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFK 1200
            SGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFK
Sbjct: 1141 SGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFK 1200

Query: 1201 RFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTD 1260
            RFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTD
Sbjct: 1201 RFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTD 1260

Query: 1261 KTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTS 1320
            KTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTS
Sbjct: 1261 KTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTS 1320

Query: 1321 PNMPKAVYIEDVIERVIQYTKFHLQNTLYPQYDPVYRLDPHGGGLLSSKAKRAKCSTHKQ 1380
            PNMPKAVYIEDVIERVIQYTKFHLQNTLYPQYDPVYRLDPHGGGLLSSKAKRAKCSTHKQ
Sbjct: 1321 PNMPKAVYIEDVIERVIQYTKFHLQNTLYPQYDPVYRLDPHGGGLLSSKAKRAKCSTHKQ 1380

Query: 1381 RVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTA 1440
            RVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTA
Sbjct: 1381 RVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTA 1440

Query: 1441 VFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQC 1500
            VFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQC
Sbjct: 1441 VFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQC 1500

Query: 1501 VVHLPSSEKDSNAEEDSNKKIDQDVVITNSYETAMRTAQNFLSIFLKKCGSKQGEEDYRP 1560
            VVHLPSSEKDSNAEEDSNKKIDQDVVITNSYETAMRTAQNFLSIFLKKCGSKQGEEDYRP
Sbjct: 1501 VVHLPSSEKDSNAEEDSNKKIDQDVVITNSYETAMRTAQNFLSIFLKKCGSKQGEEDYRP 1560

Query: 1561 LFENFVQDLLSTVNKPEWPAAELLLSLLGRLLVHQFSNKSTEMALRVASLDYLGTVAARL 1620
            LFENFVQDLLSTVNKPEWPAAELLLSLLGRLLVHQFSNKSTEMALRVASLDYLGTVAARL
Sbjct: 1561 LFENFVQDLLSTVNKPEWPAAELLLSLLGRLLVHQFSNKSTEMALRVASLDYLGTVAARL 1620

Query: 1621 RKDAVTSKMDQGSIERILKQVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQW 1680
            RKDAVTSKMDQGSIERILKQVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQW
Sbjct: 1621 RKDAVTSKMDQGSIERILKQVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQW 1680

Query: 1681 FRDTTLETEKAMKSQKDEESSEGTHHAKEIETTGQIMHRAENRKKFLRSIIKTTPSQFST 1740
            FRDTTLETEKAMKSQKDEESSEGTHHAKEIETTGQIMHRAENRKKFLRSIIKTTPSQFST
Sbjct: 1681 FRDTTLETEKAMKSQKDEESSEGTHHAKEIETTGQIMHRAENRKKFLRSIIKTTPSQFST 1740

Query: 1741 LKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVV 1800
            LKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVV
Sbjct: 1741 LKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVV 1800

Query: 1801 AVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDT 1860
            AVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDT
Sbjct: 1801 AVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDT 1860

Query: 1861 GISVRKRVIKILRDICIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPH 1920
            GISVRKRVIKILRDICIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPH
Sbjct: 1861 GISVRKRVIKILRDICIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPH 1920

Query: 1921 NDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVE 1980
            NDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVE
Sbjct: 1921 NDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVE 1980

Query: 1981 HILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQND 2040
            HILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQND
Sbjct: 1981 HILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQND 2040

Query: 2041 FMVICNVAKILELVVPLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVT 2100
            FMVICNVAKILELVVPLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVT
Sbjct: 2041 FMVICNVAKILELVVPLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVT 2100

Query: 2101 QNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLED 2160
            QNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLED
Sbjct: 2101 QNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLED 2160

Query: 2161 FKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNIL 2220
            FKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNIL
Sbjct: 2161 FKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNIL 2220

Query: 2221 SDKNSSVNLKIQVLKNLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQ 2280
            SDKNSSVNLKIQVLKNLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQ
Sbjct: 2221 SDKNSSVNLKIQVLKNLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQ 2280

Query: 2281 LYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQ 2340
            LYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQ
Sbjct: 2281 LYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQ 2340

Query: 2341 QLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIR 2400
            QLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIR
Sbjct: 2341 QLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIR 2400

Query: 2401 GNRQHRRAFLISLLNLFDDTAKTDVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVS 2460
            GNRQHRRAFLISLLNLFDDTAKTDVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVS
Sbjct: 2401 GNRQHRRAFLISLLNLFDDTAKTDVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVS 2460

Query: 2461 GSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDIN 2520
            GSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDIN
Sbjct: 2461 GSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDIN 2520

Query: 2521 SVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAI 2580
            SVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAI
Sbjct: 2521 SVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAI 2580

Query: 2581 NRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEGEVS 2640
            NRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEGEVS
Sbjct: 2581 NRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEGEVS 2640

Query: 2641 ASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGSLRRSKRNSDSTELAAQ 2700
            ASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGSLRRSKRNSDSTELAAQ
Sbjct: 2641 ASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGSLRRSKRNSDSTELAAQ 2700

Query: 2701 MNESVDVMDVIAICCPKYKDRPQIARVVQKTSSGFSVQWMAGSYSGSWTEAKRRDGRKLV 2760
            MNESVDVMDVIAICCPKYKDRPQIARVVQKTSSGFSVQWMAGSYSGSWTEAKRRDGRKLV
Sbjct: 2701 MNESVDVMDVIAICCPKYKDRPQIARVVQKTSSGFSVQWMAGSYSGSWTEAKRRDGRKLV 2760

Query: 2761 PWVDTIKESDIIYKKIALTSANKLTNKVVQTLRSLYAAKDGTSS 2804
            PWVDTIKESDIIYKKIALTSANKLTNKVVQTLRSLYAAKDGTSS
Sbjct: 2761 PWVDTIKESDIIYKKIALTSANKLTNKVVQTLRSLYAAKDGTSS 2804


>gi|47578107 delangin isoform B [Homo sapiens]
          Length = 2697

 Score = 5306 bits (13764), Expect = 0.0
 Identities = 2685/2687 (99%), Positives = 2685/2687 (99%)

Query: 1    MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDN 60
            MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDN
Sbjct: 1    MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDN 60

Query: 61   LVSQLVHSLNQVSTDHIELKDNLGSDDPEGDIPVLLQAVLARSPNVFREKSMQNRYVQSG 120
            LVSQLVHSLNQVSTDHIELKDNLGSDDPEGDIPVLLQAVLARSPNVFREKSMQNRYVQSG
Sbjct: 61   LVSQLVHSLNQVSTDHIELKDNLGSDDPEGDIPVLLQAVLARSPNVFREKSMQNRYVQSG 120

Query: 121  MMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP 180
            MMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
Sbjct: 121  MMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP 180

Query: 181  QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPR 240
            QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPR
Sbjct: 181  QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPR 240

Query: 241  HGSSEDYLHMVHRLSSDDGDSSTMRNAASFPLRSPQPVCSPAGSEGTPKGSRPPLILQSQ 300
            HGSSEDYLHMVHRLSSDDGDSSTMRNAASFPLRSPQPVCSPAGSEGTPKGSRPPLILQSQ
Sbjct: 241  HGSSEDYLHMVHRLSSDDGDSSTMRNAASFPLRSPQPVCSPAGSEGTPKGSRPPLILQSQ 300

Query: 301  SLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTL 360
            SLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTL
Sbjct: 301  SLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTL 360

Query: 361  RLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCL 420
            RLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCL
Sbjct: 361  RLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCL 420

Query: 421  SQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERI 480
            SQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERI
Sbjct: 421  SQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERI 480

Query: 481  ERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM 540
            ERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM
Sbjct: 481  ERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM 540

Query: 541  VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETP 600
            VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETP
Sbjct: 541  VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETP 600

Query: 601  KKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTE 660
            KKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTE
Sbjct: 601  KKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTE 660

Query: 661  CKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG 720
            CKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG
Sbjct: 661  CKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG 720

Query: 721  HPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVS 780
            HPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVS
Sbjct: 721  HPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVS 780

Query: 781  KHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRV 840
            KHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRV
Sbjct: 781  KHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRV 840

Query: 841  RRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS 900
            RRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS
Sbjct: 841  RRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS 900

Query: 901  NKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPK 960
            NKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPK
Sbjct: 901  NKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPK 960

Query: 961  IKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDR 1020
            IKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDR
Sbjct: 961  IKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDR 1020

Query: 1021 EDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVN 1080
            EDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVN
Sbjct: 1021 EDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVN 1080

Query: 1081 EKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRS 1140
            EKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRS
Sbjct: 1081 EKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRS 1140

Query: 1141 SGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFK 1200
            SGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFK
Sbjct: 1141 SGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFK 1200

Query: 1201 RFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTD 1260
            RFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTD
Sbjct: 1201 RFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTD 1260

Query: 1261 KTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTS 1320
            KTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTS
Sbjct: 1261 KTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTS 1320

Query: 1321 PNMPKAVYIEDVIERVIQYTKFHLQNTLYPQYDPVYRLDPHGGGLLSSKAKRAKCSTHKQ 1380
            PNMPKAVYIEDVIERVIQYTKFHLQNTLYPQYDPVYRLDPHGGGLLSSKAKRAKCSTHKQ
Sbjct: 1321 PNMPKAVYIEDVIERVIQYTKFHLQNTLYPQYDPVYRLDPHGGGLLSSKAKRAKCSTHKQ 1380

Query: 1381 RVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTA 1440
            RVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTA
Sbjct: 1381 RVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTA 1440

Query: 1441 VFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQC 1500
            VFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQC
Sbjct: 1441 VFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQC 1500

Query: 1501 VVHLPSSEKDSNAEEDSNKKIDQDVVITNSYETAMRTAQNFLSIFLKKCGSKQGEEDYRP 1560
            VVHLPSSEKDSNAEEDSNKKIDQDVVITNSYETAMRTAQNFLSIFLKKCGSKQGEEDYRP
Sbjct: 1501 VVHLPSSEKDSNAEEDSNKKIDQDVVITNSYETAMRTAQNFLSIFLKKCGSKQGEEDYRP 1560

Query: 1561 LFENFVQDLLSTVNKPEWPAAELLLSLLGRLLVHQFSNKSTEMALRVASLDYLGTVAARL 1620
            LFENFVQDLLSTVNKPEWPAAELLLSLLGRLLVHQFSNKSTEMALRVASLDYLGTVAARL
Sbjct: 1561 LFENFVQDLLSTVNKPEWPAAELLLSLLGRLLVHQFSNKSTEMALRVASLDYLGTVAARL 1620

Query: 1621 RKDAVTSKMDQGSIERILKQVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQW 1680
            RKDAVTSKMDQGSIERILKQVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQW
Sbjct: 1621 RKDAVTSKMDQGSIERILKQVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQW 1680

Query: 1681 FRDTTLETEKAMKSQKDEESSEGTHHAKEIETTGQIMHRAENRKKFLRSIIKTTPSQFST 1740
            FRDTTLETEKAMKSQKDEESSEGTHHAKEIETTGQIMHRAENRKKFLRSIIKTTPSQFST
Sbjct: 1681 FRDTTLETEKAMKSQKDEESSEGTHHAKEIETTGQIMHRAENRKKFLRSIIKTTPSQFST 1740

Query: 1741 LKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVV 1800
            LKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVV
Sbjct: 1741 LKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVV 1800

Query: 1801 AVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDT 1860
            AVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDT
Sbjct: 1801 AVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDT 1860

Query: 1861 GISVRKRVIKILRDICIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPH 1920
            GISVRKRVIKILRDICIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPH
Sbjct: 1861 GISVRKRVIKILRDICIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPH 1920

Query: 1921 NDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVE 1980
            NDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVE
Sbjct: 1921 NDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVE 1980

Query: 1981 HILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQND 2040
            HILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQND
Sbjct: 1981 HILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQND 2040

Query: 2041 FMVICNVAKILELVVPLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVT 2100
            FMVICNVAKILELVVPLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVT
Sbjct: 2041 FMVICNVAKILELVVPLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVT 2100

Query: 2101 QNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLED 2160
            QNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLED
Sbjct: 2101 QNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLED 2160

Query: 2161 FKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNIL 2220
            FKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNIL
Sbjct: 2161 FKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNIL 2220

Query: 2221 SDKNSSVNLKIQVLKNLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQ 2280
            SDKNSSVNLKIQVLKNLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQ
Sbjct: 2221 SDKNSSVNLKIQVLKNLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQ 2280

Query: 2281 LYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQ 2340
            LYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQ
Sbjct: 2281 LYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQ 2340

Query: 2341 QLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIR 2400
            QLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIR
Sbjct: 2341 QLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIR 2400

Query: 2401 GNRQHRRAFLISLLNLFDDTAKTDVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVS 2460
            GNRQHRRAFLISLLNLFDDTAKTDVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVS
Sbjct: 2401 GNRQHRRAFLISLLNLFDDTAKTDVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVS 2460

Query: 2461 GSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDIN 2520
            GSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDIN
Sbjct: 2461 GSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDIN 2520

Query: 2521 SVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAI 2580
            SVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAI
Sbjct: 2521 SVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAI 2580

Query: 2581 NRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEGEVS 2640
            NRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEGEVS
Sbjct: 2581 NRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEGEVS 2640

Query: 2641 ASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGSLRR 2687
            ASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSG  RR
Sbjct: 2641 ASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGVRRR 2687


>gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]
          Length = 715

 Score =  100 bits (248), Expect = 3e-20
 Identities = 157/678 (23%), Positives = 233/678 (34%), Gaps = 104/678 (15%)

Query: 588  SLKSTPENHPETPKKKS-------DPELSKSEMKQSESRLAESKPNENRLVETKSSENKL 640
            S KS   N    P K +        P  SKS    S  R   ++P+    V +K+   + 
Sbjct: 34   STKSATPNRSLVPTKPATSRNSVMSPSSSKSTKSTSTKRAPSNRPSSRSRVRSKA---RT 90

Query: 641  ETKVETQTEELKQNESRTTECKQNESTIVE---PKQNENRLSDTKPNDNKQNNGRSETTK 697
             ++V T T   K +++    C Q   T      P +  +R S   P+      GR  T  
Sbjct: 91   PSRVSTDTRTSKASKASDVRCHQRRGTHSRGRTPGRRGSRSSKRSPS-RASTPGRIRTHG 149

Query: 698  SRP--------ETPKQKGE-----SRPETP-KQKSDGHPETPKQKGDGRPETPKQKGESR 743
            +RP         T +QKG       RP T  +++SD  P    +K   RP      G S 
Sbjct: 150  ARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSY-RPPGGSGIGRSS 208

Query: 744  -----PETPK-QKNEGRPETPKHRHDNRRDSGKPSTEKK---------PEVSKHKQDTKS 788
                 P T K Q   G P   K       D+  PS+ +K         P   K    T+ 
Sbjct: 209  ELAVTPSTAKCQTPTGIPSKEKS------DNPSPSSSRKVKSYGQMIIPSREKSYSPTEM 262

Query: 789  DSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQK-------------SDDRGESERHRG 835
             S R+KS    + + RP   S S S RR     QK             +  R  S   +G
Sbjct: 263  SS-RVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKG 321

Query: 836  DQSRVRRPETLRSSSRNE---------HGIKSDSSKTDKLERKHRHESGDSRERPSSGEQ 886
              S++ R    RS S+ +          G   + S+    ER H H    S+ER   G  
Sbjct: 322  ILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSS 381

Query: 887  KSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLL 946
              R +S R + G  NK R          ++D  R+       D +++   NKA   S   
Sbjct: 382  SPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCS--- 438

Query: 947  GGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQ 1006
              RS +      P   RD+  + +    +   +    +K        D ++   P     
Sbjct: 439  --RSRS------PYKARDRSRSRSPNKARDHSRSRSPNK------ARDRSRSRSPSKERD 484

Query: 1007 KLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLC 1066
               L    K    R  +S S  +  +   S S +    +S     P +     +S  P  
Sbjct: 485  HSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRS---RSPSKERQRRQSRSPNK 541

Query: 1067 ERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDR-RSS 1125
            ER +   R  S   E  +    S + D     +    R+R +         EERD  RS 
Sbjct: 542  ERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSS----EERDHSRSR 597

Query: 1126 GDHRRSGHSHEGRRSSGGGRYRNRSP------SDSDMEDYSPPPSLSEVARKMKKKEKQK 1179
              +++SG+S     S      R+R+P      S S        PS S V R    K    
Sbjct: 598  SPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPT 657

Query: 1180 KRKAYEPKLTPEEMMDSS 1197
            +  +     TP +    S
Sbjct: 658  RTSSLSQNRTPSKTSSHS 675



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 48/211 (22%), Positives = 96/211 (45%), Gaps = 14/211 (6%)

Query: 599 TPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKS-SENKLETKVETQTEELKQNESR 657
           +P K+ D   S+S  K+ + R + S   E     ++S S+ +   +  +  +E  +++SR
Sbjct: 490 SPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSR 549

Query: 658 TTECKQNESTIVEPKQNENRL---SDTKPNDNKQNNGRSETTK-SRPETP-KQKGESRPE 712
           +   ++       P +  +R    S +K  + +Q+   SE    SR  +P KQ G SRP 
Sbjct: 550 SPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPR 609

Query: 713 -TPKQKSDGHPETPKQKGDGRPE--TPKQKGESRPETPKQKNEGRPET-----PKHRHDN 764
            + K+K+     TP ++G+      + K+   S+   P+  +  R  T      ++R  +
Sbjct: 610 ASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPS 669

Query: 765 RRDSGKPSTEKKPEVSKHKQDTKSDSPRLKS 795
           +  S  PST      +  + D+++D+   K+
Sbjct: 670 KTSSHSPSTFPSGGQTLSQDDSQADATTSKA 700



 Score = 39.7 bits (91), Expect = 0.042
 Identities = 27/120 (22%), Positives = 52/120 (43%), Gaps = 2/120 (1%)

Query: 597 PETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNES 656
           P   +++     S  E   S SR    +   +R     SS+ K  ++  T ++E   ++S
Sbjct: 575 PSKERERRQSRSSSEERDHSRSRSPNKQSGYSR--PRASSKEKAHSRSRTPSKEGNHSQS 632

Query: 657 RTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQ 716
           RT+  + + S    P+  + + S T+ +   QN   S+T+   P T    G++  +   Q
Sbjct: 633 RTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQ 692



 Score = 35.8 bits (81), Expect = 0.61
 Identities = 37/186 (19%), Positives = 71/186 (38%), Gaps = 29/186 (15%)

Query: 590 KSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLE-TKVETQT 648
           K        +P K+     S+S  K+ + R + S   E +  +++S   + + ++  + +
Sbjct: 493 KERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPS 552

Query: 649 EELKQNESRTTECKQNESTIVEP-KQNENRLSDTKPNDNKQNNGRS-------------- 693
           EE +  +SR+   +++      P K+ E R S +   +   +  RS              
Sbjct: 553 EEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASS 612

Query: 694 -ETTKSRPETPKQKGE-SRPETPKQKSDGHPETPKQKGD-----------GRPETPKQKG 740
            E   SR  TP ++G  S+  T  ++SD    T  +  D            +  TP +  
Sbjct: 613 KEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTS 672

Query: 741 ESRPET 746
              P T
Sbjct: 673 SHSPST 678


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 99.0 bits (245), Expect = 6e-20
 Identities = 158/736 (21%), Positives = 270/736 (36%), Gaps = 104/736 (14%)

Query: 253 RLSSDDGDSSTMRNAASF-PLRSPQPVCSPAGSEGTPKGSRP-PLILQSQSLPCSSPRDV 310
           RL +  G S +  + +SF P R  +    PA     P+  +P  L+ +S S    +P+  
Sbjct: 134 RLRAAFGISDSYVDGSSFDPQRRAREAKQPA-----PEPPKPYSLVRESSSSRSPTPKQK 188

Query: 311 PPDILLD--------SPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLRL 362
                 D        SP R++KK  K K  + E E  ++        SP+  S + +   
Sbjct: 189 KKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKH-----RSPTPKSKRKSKDK 243

Query: 363 SRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQ 422
            R RS                  S    P + +    TS    +  D +R   +    ++
Sbjct: 244 KRKRSR-----------------STTPAPKSRRAHRSTSADSASSSDTSRS-RSRSAAAK 285

Query: 423 QEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIER 482
              TA    +  P   +     A   +      Q+  S                      
Sbjct: 286 THTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSP--------------------- 324

Query: 483 ESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVS 542
           E+A ++     E +DKDK  K   + S P     +TG   PA     +  +G  P  + +
Sbjct: 325 ETATKQPSSPYEDKDKDKKEKSATRPS-PSPERSSTGPEPPAPTPLLAERHGGSPQPLAT 383

Query: 543 IDLHQAG-RVDSQASITQDSDSIKKPEEIKQCN---DAPVSVLQEDIVGSLKSTPENHPE 598
             L Q      S+AS T+D    K PE++ Q +    +P S     +     S+PE+   
Sbjct: 384 TPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKP 443

Query: 599 TPKKKSDPELSKSEMKQSESR------LAESKPNENRLVETKSSENKLETKVETQTEELK 652
            P   S  E+S S   ++ S        + S     R+  ++S       +  ++T   +
Sbjct: 444 APAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKR 503

Query: 653 -QNESRTTECKQNEST-----IVEPKQNENRLSDTKP----NDNKQNNGRSETT---KSR 699
             + SR+ + +++ S         P++     S  +P    + N Q  GRS +    +S 
Sbjct: 504 GHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSH 563

Query: 700 PETPKQKGESRPETPKQKSDGHPETPKQKGD---------GRPETPKQKGESRPETPKQK 750
             +P  +G SR  TP ++      TP ++            R  TP ++G SR  TP ++
Sbjct: 564 SRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARR 623

Query: 751 NEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSV 810
              R  +P  R    R   + S   +      +  ++S +P  +         R  GRS 
Sbjct: 624 -RSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSR 682

Query: 811 SESLRRDHDNKQKSDDRGESERH---RGDQSRVRRPETL-RSSSRNEHGIKSDSSKTDKL 866
           S +  R   ++ ++  RG S      R  +S  R P+   RS S +E   KS +S     
Sbjct: 683 SRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTS----- 737

Query: 867 ERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKS 926
           +R+ R  S    ++     ++SR  S    +  S  S    L   SP  K   +T   +S
Sbjct: 738 QRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRS 797

Query: 927 KVDTNKAHPDNKAEFP 942
           +  +  + P  K+  P
Sbjct: 798 R--SGSSQPKAKSRTP 811



 Score = 85.1 bits (209), Expect = 9e-16
 Identities = 121/544 (22%), Positives = 203/544 (37%), Gaps = 103/544 (18%)

Query: 483 ESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVS 542
           E+A ++     E +DKDK  K   + S P     +TG   PA     +  +G  P  + +
Sbjct: 325 ETATKQPSSPYEDKDKDKKEKSATRPS-PSPERSSTGPEPPAPTPLLAERHGGSPQPLAT 383

Query: 543 IDLHQAG-RVDSQASITQDSDSIKKPEEIKQCNDA---PVSVLQEDIVGSLKSTPENHPE 598
             L Q      S+AS T+D    K PE++ Q + +   P S     +     S+PE+   
Sbjct: 384 TPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKP 443

Query: 599 TPKKKSDPELSKSEMKQSESR------LAESKPNENRLVETKSSENKLETKVETQTEELK 652
            P   S  E+S S   ++ S        + S     R+  ++S       +  ++T   +
Sbjct: 444 APAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKR 503

Query: 653 -QNESRTTECKQNEST-----IVEPKQNENRLSDTKP----NDNKQNNGRSETTK----- 697
             + SR+ + +++ S         P++     S  +P    + N Q  GRS + +     
Sbjct: 504 GHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSH 563

Query: 698 ---------SRPETPKQKGESRPETPKQKSD--------------------GHPETP--- 725
                    SR  TP ++G SR  TP ++                          TP   
Sbjct: 564 SRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARR 623

Query: 726 ------------------KQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRD 767
                             ++ G  R  TP ++G SR  TP ++   R  TP  R      
Sbjct: 624 RSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARR------ 677

Query: 768 SGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRR----DHDNKQK 823
               S   +      +  ++S +PR    R+ +L +R  GRS S + +R       +++K
Sbjct: 678 ----SGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRR--GRSHSRTPQRRGRSGSSSERK 731

Query: 824 SDDRGESERHRGDQSRVRRPETLRS--SSRNEHGIKSDSSKTDKLERKHRHESGDS---R 878
           +  R    R R + S    PE  +S  SSR    + S  SK        R  SG S   +
Sbjct: 732 NKSRTSQRRSRSNSS----PEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPK 787

Query: 879 ERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNK 938
           ++  +  ++SR  S + K       R  +    SP  K   +T   +S   ++  HP  K
Sbjct: 788 QKSQTPPRRSRSGSSQPKAKSRTPPRRSR-SSSSPPPKQKSKTPSRQSH-SSSSPHPKVK 845

Query: 939 AEFP 942
           +  P
Sbjct: 846 SGTP 849



 Score = 68.9 bits (167), Expect = 7e-11
 Identities = 220/1134 (19%), Positives = 374/1134 (32%), Gaps = 183/1134 (16%)

Query: 124  SQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAPQSP 183
            S+  L ++   SSP      QT    S S    P   S   R  P+++    SP   Q  
Sbjct: 771  SRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKS---RTPPRRSRSSSSPPPKQKS 827

Query: 184  AGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGS 243
                  SH SS + HP+++  +   P   G + +   N+ S      S    + +P   S
Sbjct: 828  KTPSRQSHSSS-SPHPKVKSGT---PPRQGSITSPQANEQSVTPQRRSCFESSPDPELKS 883

Query: 244  SEDYLHMVHRLSSDDGDSSTMRNAASFPLRSPQP----VCSPAGSEGTPKGSRPPLILQS 299
                 H     S     SST    +     SPQP    + SP     +   S  P  + S
Sbjct: 884  RTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTS 943

Query: 300  QSLPCSSPRDVPPDILLDS-------------PERKQKKQKKMKLGKDEKEQSEKAAMYD 346
            ++ P  S R V P   ++S             P+ K K +   +                
Sbjct: 944  RTTPRRS-RSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQ 1002

Query: 347  IISSPSKDSTKLTLRLSRVRSSDMDQQEDMIS---GVENSNVSENDI--PFNVQYPGQTS 401
                PS   +K      + + S +      +S   GV++S           ++Q  GQ+ 
Sbjct: 1003 TPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQ 1062

Query: 402  KTPITPQDINRP---LNAAQCLSQQEQTAFLP--------------ANQVPVLQQNTSVA 444
             +P    D + P    + ++  S Q ++   P              A++ P+ Q     +
Sbjct: 1063 TSPDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFS 1122

Query: 445  AKQP-QTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIER-------ERFSKEVQ 496
            A    ++ +   Q +       Y  V+ ++L    R+E   + E+       +  +   +
Sbjct: 1123 ASPMLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDATASPPR 1182

Query: 497  DKDK----PLKKRKQDSY---------PQEAGGATGGNRPASQETGSTGNGSRPALMVSI 543
             KDK    P++ R + S          P+E  GA        Q +    +     LM  +
Sbjct: 1183 QKDKFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPETKEQNSALPTSSQDEELMEVV 1242

Query: 544  DLHQ--AGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENH-PETP 600
            +  +  AG++ S  S      S    E   +  + P   L  D   S  S      P   
Sbjct: 1243 EKSEEPAGQILSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQASLEAVEVPSMA 1302

Query: 601  KKKSDPELSKSEMKQSESRLAESK-------PNENRLVETKSSENKLETKVETQTEELKQ 653
                 P  S    + S S L E+         N   L    ++    E K +     L Q
Sbjct: 1303 SSWGGPHFSPEHKELSNSPLRENSFGSPLEFRNSGPLGTEMNTGFSSEVKEDLNGPFLNQ 1362

Query: 654  NESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGR--SETTKSRPETPKQKGESRP 711
             E+  +   + +ST      +     D        +N    S    + P TP ++  S  
Sbjct: 1363 LETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSA 1422

Query: 712  ETPKQKSDGHPETPKQK-----------GDGRPETPKQKGES--RPETPKQKNEGR---- 754
             +P+ K DG P TP ++           G G P      G S    + P+  + GR    
Sbjct: 1423 SSPEMK-DGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECD 1481

Query: 755  --------PETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPD 806
                    P+TP+ R    R    P    K    + ++     S   K+     L QR  
Sbjct: 1482 SSPEPKALPQTPRPRS---RSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSR 1538

Query: 807  GRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKL 866
              S  E    D        +R ES+     +++ R P   RS S +   + S S  + + 
Sbjct: 1539 SGSSQEL---DVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPR- 1594

Query: 867  ERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKS 926
                R  SG      SS E K +P +    Q  S+ S   K    +P +   +   G+ S
Sbjct: 1595 ----RSRSG------SSPEVKDKPRAAPRAQSGSDSSPEPKA--PAPRALPRRSRSGSSS 1642

Query: 927  K----VDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEP 982
            K         +  ++  E P                PK +  + G+ +    K + +  P
Sbjct: 1643 KGRGPSPEGSSSTESSPEHP----------------PKSRTARRGSRSSPEPKTKSRTPP 1686

Query: 983  KDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGS 1042
            + +                     + S +  +K    R  +S SS    +++    ++ S
Sbjct: 1687 RRR-------------------SSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRS 1727

Query: 1043 IDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFES 1102
                            + S  P  E+ + ++R+RS  + + K         +      + 
Sbjct: 1728 --------------PSVSSPEP-AEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQR 1772

Query: 1103 SRKRHKKDDDKAWEYEERDRRSSGDHRR----SGHSHEGRRSSGGGRYRNRSPS 1152
            SR R +++  +     +R   S    RR       S   RR  GG  Y +RSP+
Sbjct: 1773 SRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPA 1826



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 138/695 (19%), Positives = 249/695 (35%), Gaps = 116/695 (16%)

Query: 395  QYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPA-NQVPVLQQNTSVAAKQPQTSVV 453
            Q P   S++P +P+  N+ L   +  S  E +       + P+ Q++ S ++++      
Sbjct: 1491 QTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPS 1550

Query: 454  QNQQQISQQG-----------PIYDEVELDALAEIERIERESAIE-RERFSKEVQDKDK- 500
             + Q+ S+             P+       +  E++   R S    R   S EV+DK + 
Sbjct: 1551 ASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRA 1610

Query: 501  -PLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQAGRVDSQASITQ 559
             P  +   DS P+    A     P    +GS+  G  P+                +S T+
Sbjct: 1611 APRAQSGSDSSPEPKAPAPRA-LPRRSRSGSSSKGRGPS-------------PEGSSSTE 1656

Query: 560  DSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESR 619
             S     PE   +   A           +   TP   P     +S PEL++       SR
Sbjct: 1657 SS-----PEHPPKSRTARRGSRSSPEPKTKSRTP---PRRRSSRSSPELTRKARLSRRSR 1708

Query: 620  LAESKPN-------ENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPK 672
             A S P         +R   + SS    E    ++      +    T  ++  S   +P+
Sbjct: 1709 SASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPR 1768

Query: 673  -----QNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG---HPET 724
                 ++ +R   T+    +  +G S++T  R    +Q+  SR    +++  G   H  +
Sbjct: 1769 GLQRSRSRSRREKTRTTRRRDRSGSSQSTSRR----RQRSRSRSRVTRRRRGGSGYHSRS 1824

Query: 725  PKQKGDGRPETPKQKGESR-PETPKQKNEGRPETPKHRHDNRRDSG---KPSTEKKPEVS 780
            P ++   R  + +++G SR P T ++++  R      +    R S    + S  + P +S
Sbjct: 1825 PARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLIS 1884

Query: 781  KHKQDTKSD--SPRLKSERAEALKQRPDGRSVSESLRRDHDN-----KQKSDDRGESERH 833
            + +  +++   S R    R    ++R   R+   S RR         +++S  R  + R 
Sbjct: 1885 RRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRR 1944

Query: 834  RGD---------QSRVRRPETLRSSSRNEHGI----------------KSDSSKTDKLER 868
            R           +SR R P   R  SR+                    +S S  +    R
Sbjct: 1945 RSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRR 2004

Query: 869  KHRHESGD-----SRER-PSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTE 922
            + R  +       SR R P +  ++SR  +P + +  S +SRS     +   S+  +   
Sbjct: 2005 RSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRS-RSRSPLAIRRRSRSRTPRTAR 2063

Query: 923  GNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQET--------- 973
            G +S   +  A     A        G S        P   R+  G+ T            
Sbjct: 2064 GKRSLTRSPPAIRRRSAS-------GSSSDRSRSATPPATRNHSGSRTPPVALNSSRMSC 2116

Query: 974  -KKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQK 1007
              +  M   P D+    G++E L     P+ VLQ+
Sbjct: 2117 FSRPSMSPTPLDRCRSPGMLEPLGSSRTPMSVLQQ 2151



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 173/884 (19%), Positives = 313/884 (35%), Gaps = 124/884 (14%)

Query: 285  EGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAM 344
            E +  GS P    Q+ +LP SS  +   +++  S E     Q    L  + KE S     
Sbjct: 1212 ERSGAGSSPETKEQNSALPTSSQDEELMEVVEKSEE--PAGQILSHLSSELKEMSTS--- 1266

Query: 345  YDIISSPS---KDSTKLTLRLSRVRSSDMDQQEDMISGVENSNVSEN--DIPFNVQYPGQ 399
             +  SSP    + +  LTL        D  Q +  +  VE  +++ +     F+ ++  +
Sbjct: 1267 -NFESSPEVEERPAVSLTL--------DQSQSQASLEAVEVPSMASSWGGPHFSPEHK-E 1316

Query: 400  TSKTPITPQDINRPLNAAQC--LSQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQ 457
             S +P+       PL       L  +  T F  +++V        +   +   S+   +Q
Sbjct: 1317 LSNSPLRENSFGSPLEFRNSGPLGTEMNTGF--SSEVKEDLNGPFLNQLETDPSLDMKEQ 1374

Query: 458  QISQQGPIYDEVELDALAE-------------IERIERESAIERERFSKEVQDKD----K 500
                 G    E+  DA+ +             ++ + R  + ER   +   + KD     
Sbjct: 1375 STRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPRT 1434

Query: 501  PLKKRKQDSYPQEAGGA-------TGGNRPASQETGSTGNGSRPALMVSID---LHQAGR 550
            P ++ +  S P    G+         G+ P  ++   T +  R     S +   L Q  R
Sbjct: 1435 PSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPR 1494

Query: 551  VDSQAS---------ITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPK 601
              S++          +T   +       + Q   A   + Q    GS +        +P+
Sbjct: 1495 PRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQ 1554

Query: 602  KKSDPELSKSEMKQSESRLAE-SKPNENRLVETKSSENKLETKVETQTEELKQNESRTTE 660
            ++S+ + S     ++ + L + S+   +  V++KS  +   ++    + E+K        
Sbjct: 1555 ERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSR-SGSSPEVKDKPRAAPR 1613

Query: 661  CKQNESTIVEPKQNENRLSDTKPNDNKQNNGR------SETTKSRPETPKQ-----KGES 709
             +    +  EPK    R    +      + GR      S +T+S PE P +     +G  
Sbjct: 1614 AQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSR 1673

Query: 710  RPETPKQKSDGHPETPKQKGDGR--PE-TPKQKGESRPETPKQKNEGRPETPKHRHDNRR 766
                PK KS     TP ++   R  PE T K +   R  +     E R  TP  RH    
Sbjct: 1674 SSPEPKTKS----RTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPP-RHRRSP 1728

Query: 767  DSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDG--RSVSESLRRDHDNKQKS 824
                P   +K   S+ ++   S   +  S R  +   +P G  RS S S R      ++ 
Sbjct: 1729 SVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRR 1788

Query: 825  DDRGESE-----RHRG-DQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSR 878
            D  G S+     R R   +SRV R     S   +    + +SS+T    R+     G SR
Sbjct: 1789 DRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRR-----GRSR 1843

Query: 879  ERPSSGEQKSRPDSP--------RVKQGDSNKSRS-----DKLGFKSPTSKDDKRTEGNK 925
              P+S ++     SP        R       +SRS      +   +S TS   +R   ++
Sbjct: 1844 TPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRRSRSRTSPVSRRRSRSR 1903

Query: 926  SKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEP--- 982
            + V   ++        P      RS        P + R +  + T  T++      P   
Sbjct: 1904 TSVTRRRS---RSRASPVSRRRSRSRT------PPVTRRRSRSRTPTTRRRSRSRTPPVT 1954

Query: 983  -KDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKG 1041
             +    +   V      ++   + ++ S      + + R   SRS   P+  + S+S   
Sbjct: 1955 RRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRR---SRSRTSPVTRRRSRSRTS 2011

Query: 1042 SIDQSVLK-ELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPK 1084
             + +   +   PP +     S  PL  R +   R    +  + +
Sbjct: 2012 PVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSR 2055



 Score = 55.8 bits (133), Expect = 6e-07
 Identities = 111/563 (19%), Positives = 199/563 (35%), Gaps = 107/563 (19%)

Query: 437 LQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQ 496
           L++  +   K+P   ++ ++++          VEL  L E+E +  E   E ++  ++V 
Sbjct: 42  LRRLEAALVKRPNPDILDHERK--------RRVELRCL-ELEEMMEEQGYEEQQIQEKVA 92

Query: 497 DKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGS-------RPALMVSIDLHQAG 549
                L ++  +   +E    T G RPA  ET      +       R A  +S       
Sbjct: 93  TFRLMLLEKDVNPGGKEE---TPGQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGS 149

Query: 550 RVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELS 609
             D Q    +      +P +       P S+++E       S+    P   +KK   +  
Sbjct: 150 SFDPQRRAREAKQPAPEPPK-------PYSLVRE-------SSSSRSPTPKQKKKKKKKD 195

Query: 610 KSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTIV 669
           +    +S S   E K +  +      SE+K + K  + T + K+ +S+  + K++ ST  
Sbjct: 196 RGRRSESSSPRRERKKSSKKKKHRSESESK-KRKHRSPTPKSKR-KSKDKKRKRSRSTTP 253

Query: 670 EPKQNENRLSDT--KPNDNKQNNGRSETTKSRPETPKQKGE----------------SRP 711
            PK      S +    + +  +  RS +  ++  T    G                 S P
Sbjct: 254 APKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEP 313

Query: 712 ETPKQKSDGHPET----PKQKGDGRPETPKQKGESRPETPKQKNEGRPETP------KHR 761
            T   +    PET    P    + + +  K+K  +RP    +++   PE P        R
Sbjct: 314 GTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAER 373

Query: 762 HDN-----------------------RRDSGKP-STEKKPEVSKHKQDTKSDSPRLKSER 797
           H                          RD   P S EK P+ S  +    S  P   S  
Sbjct: 374 HGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRH 433

Query: 798 AEALKQRP-------DGRSVSES-LRRDHDNKQKSDDRGESERHRGDQSRVRRPETL-RS 848
           A +  + P         R +S S   ++  + +   D+  S        R R P T  R 
Sbjct: 434 ASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRG 493

Query: 849 SSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPR----------VKQG 898
            SR+    K   S++ +  +  R  S     R  S +++ R  SP+           ++G
Sbjct: 494 RSRSRTPTKRGHSRS-RSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRG 552

Query: 899 DSNKSRSDKLGFKSPTSKDDKRT 921
            S  +R  +   +SP ++   R+
Sbjct: 553 RSRSARRGRSHSRSPATRGRSRS 575



 Score = 54.3 bits (129), Expect = 2e-06
 Identities = 97/446 (21%), Positives = 158/446 (35%), Gaps = 66/446 (14%)

Query: 731  GRPETPKQKG-----ESRPETPKQKNE--------------GRPETPKHRHDNRRDSGKP 771
            G+ ETP Q+          E  ++KNE              G    P+ R    R++ +P
Sbjct: 107  GKEETPGQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRR---AREAKQP 163

Query: 772  STEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESE 831
            + E     S  ++ + S SP  K ++ +  K R   RS S S RR+     K        
Sbjct: 164  APEPPKPYSLVRESSSSRSPTPKQKKKKKKKDR-GRRSESSSPRRERKKSSKKKKHRSES 222

Query: 832  RHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPD 891
              +  + R   P++ R S   +      ++   K  R HR  S DS    SS   +SR  
Sbjct: 223  ESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSAS--SSDTSRSRSR 280

Query: 892  SPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNK--SKVDTNKAHPDNKAEFPSYLLGGR 949
            S       + K+ +  L  +SP+    +R EG+   S+  T      +  E         
Sbjct: 281  SA------AAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPE--------- 325

Query: 950  SGALKNFVIPKIKRDKD---GNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQ 1006
              A K    P   +DKD    + T+ +   E      +      L+ + + G+   +   
Sbjct: 326  -TATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATT 384

Query: 1007 KLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLC 1066
             LS + V    +    + RS  K  +  P  S+                    ES+ P  
Sbjct: 385  PLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSS-------------------ESSPPSP 425

Query: 1067 ERVKMNKRKRST-VNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSS 1125
            +  K+++   S+  + KP  A  S  E + S  +   S  R K+D   +     R  RS 
Sbjct: 426  QPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSR 485

Query: 1126 GDHRRSGHSHEGRRSSGGGRYRNRSP 1151
                        R  +  G  R+RSP
Sbjct: 486  SPATAKRGRSRSRTPTKRGHSRSRSP 511



 Score = 45.4 bits (106), Expect = 8e-04
 Identities = 46/239 (19%), Positives = 85/239 (35%), Gaps = 17/239 (7%)

Query: 601  KKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTE 660
            +++S    S S    S S  + S  + +    + S  + L  + E   + +        E
Sbjct: 2529 ERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKE 2588

Query: 661  C-KQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSD 719
              ++       P + + R S +  + +  ++  S ++ S   +      S   +    S 
Sbjct: 2589 AVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2648

Query: 720  GHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEV 779
              P  P     G    PK     +P   ++++    +      D+R  S  P   ++P  
Sbjct: 2649 PSPAKP-----GPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSP 2703

Query: 780  SKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQS 838
                +D +S S    SER     QR D RS S   RR+  + +         RHR  +S
Sbjct: 2704 QPSPRDQQSSS----SERGSRRGQRGDSRSPSHKRRRETPSPRPM-------RHRSSRS 2751



 Score = 37.7 bits (86), Expect = 0.16
 Identities = 54/250 (21%), Positives = 91/250 (36%), Gaps = 27/250 (10%)

Query: 129  SQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAPQSPAGYMP 188
            SQ+ M S  A S    + +  +PS   +PP          Q  SPVPS ++ QS      
Sbjct: 2415 SQSRMTSERAPS--PSSRMGQAPSQSLLPPAQD-------QPRSPVPSAFSDQSRCLIAQ 2465

Query: 189  YSHPSSYTTHPQMQQASVSSPIVAGGLRNI--HDNKVSGPLSGNSANHHADNPRHGSSED 246
                    T P     S+SS  VA    +   H+  +S P  G   +   + P    ++ 
Sbjct: 2466 --------TTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQ 2517

Query: 247  YLHMV--------HRLSSDDGDSSTMRNAASFPLRSPQPVCSPAGSEGTPKGSRPPLILQ 298
               +            SS    SS+  +++S    S     S + SEG+    +P + L+
Sbjct: 2518 PSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALK 2577

Query: 299  SQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKL 358
                P  +P++   +     P   ++K++           S  ++     SS S  S+  
Sbjct: 2578 RVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2637

Query: 359  TLRLSRVRSS 368
            +   S   SS
Sbjct: 2638 SSSSSSSSSS 2647



 Score = 34.3 bits (77), Expect = 1.8
 Identities = 54/276 (19%), Positives = 103/276 (37%), Gaps = 52/276 (18%)

Query: 500  KPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQAGRVDSQASI-- 557
            +P K+R+  S    +  ++  +  +S  + S+G+ S                DS+ S   
Sbjct: 2525 QPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSS---------------DSEGSSLP 2569

Query: 558  TQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSE 617
             Q   ++K+   +     AP   ++E         PE  P   K++S    S S    S 
Sbjct: 2570 VQPEVALKR---VPSPTPAPKEAVREG------RPPEPTPAKRKRRSSSSSSSSSSSSSS 2620

Query: 618  SRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENR 677
            S  + S  +      + SS +   +   + +           +     ++  +P   E R
Sbjct: 2621 SSSSSSSSS------SSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERR 2674

Query: 678  -LSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPE-TPKQKSDGHPETPKQKGDGRPET 735
              S  KP D+ ++      ++S   +P ++    P+ +P+ +     E   ++G      
Sbjct: 2675 SRSPRKPIDSLRD------SRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRG------ 2722

Query: 736  PKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKP 771
              Q+G+SR  + K+    R ETP  R    R S  P
Sbjct: 2723 --QRGDSRSPSHKR----RRETPSPRPMRHRSSRSP 2752


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 87.0 bits (214), Expect = 2e-16
 Identities = 115/605 (19%), Positives = 230/605 (38%), Gaps = 82/605 (13%)

Query: 477  IERIERESAI-----ERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGS- 530
            +E+ E+E+ I     E  + ++EV ++++  K+ K++   +E GG         +ET S 
Sbjct: 447  VEKSEKETVIVEEQTEETQVTEEVTEEEE--KEAKEEEGKEEEGGEEEEAEGGEEETKSP 504

Query: 531  -TGNGSRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQE-DIVGS 588
                 + P       + +  +  ++A  + + +  K P E+K    A     +E      
Sbjct: 505  PAEEAASPEKEAKSPVKEEAKSPAEAK-SPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPE 563

Query: 589  LKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQT 648
             KS  +   ++P +   PE +KS  K+     AE+K           S  K ++ V+   
Sbjct: 564  AKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAK-----------SPEKAKSPVK--- 609

Query: 649  EELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGE 708
            EE K      +  K+   +  E K  E   S TK         +S      PE  + K  
Sbjct: 610  EEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKS------PEKEEAKSP 663

Query: 709  SRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDS 768
             + ++P +     PE  K      P   + K   + ++P ++    PE  K +   + ++
Sbjct: 664  EKAKSPVKAEAKSPEKAKS-----PVKAEAKSPEKAKSPVKEEAKSPE--KAKSPVKEEA 716

Query: 769  GKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRG 828
              P   K P   + K   K+ SP  +  ++    + P+     +    +     K + R 
Sbjct: 717  KSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARS 776

Query: 829  ESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDK-----------LERKHRHESGDS 877
             +++   ++++    E ++S  + +  +K D+   +K           ++ + + +    
Sbjct: 777  PADKF-PEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKV 835

Query: 878  RERPSSGEQKSRPDSPRVKQ-GDSNKSRSDKLGFKSPTSKDDKRTEGNK---SKVDTNKA 933
            +E P   E++  P +P+ ++  DS K  + K     P  ++ K     K   SKV+  K 
Sbjct: 836  KEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKE 895

Query: 934  HPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVE 993
              ++K + P+                    +K+     E K+     +PK+K E      
Sbjct: 896  EAEDKKKVPT-------------------PEKEAPAKVEVKE---DAKPKEKTEVAKKEP 933

Query: 994  DLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPP 1053
            D  K  +P    +K      ++   +++D      K  + KP    K   D   L + P 
Sbjct: 934  DDAKAKEPSKPAEK------KEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPS 987

Query: 1054 ELLAE 1058
            +  AE
Sbjct: 988  KPKAE 992



 Score = 77.4 bits (189), Expect = 2e-13
 Identities = 122/597 (20%), Positives = 229/597 (38%), Gaps = 68/597 (11%)

Query: 591  STPENHPETP------KKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKV 644
            S PE  P+ P      K KS+ ++   E  + E+ + E +  E ++ E  + E + E K 
Sbjct: 421  SLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKE 480

Query: 645  ET-------QTEELKQNESRTTECKQNESTIVEPKQN----ENRLSDTKPNDNKQNNGRS 693
            E        + EE +  E  T      E+   E +      E   S  +    ++   +S
Sbjct: 481  EEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKS 540

Query: 694  ETTKSRPETPKQKGESR---------PETPKQKSDGHPETPKQKGDGRPETPKQKGESR- 743
                  PE  K   +           PE  + KS    ++P++      E  K   E++ 
Sbjct: 541  PAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKS 600

Query: 744  PETPKQKNEGRPETPKHRHDNRRDSGK-PSTEKKPEVSKHKQDTKSDSP-RLKSERAEAL 801
            PE  K   +   ++P       ++  K P+  K PE +K     ++ SP + KS   E  
Sbjct: 601  PEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEA 660

Query: 802  KQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRR----PETLRSSSRNE---- 853
            K     +S  ++  +  + K KS  + E++     +S V+     PE  +S  + E    
Sbjct: 661  KSPEKAKSPVKAEAKSPE-KAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSP 719

Query: 854  HGIKS---DSSKTDKLERKHRHESGDSRERPSSGEQKSRPD--SPRVKQGDSNKSRSDKL 908
               KS   + +KT +  +    E   S E+  S E+    D  SP  K     ++RS   
Sbjct: 720  EKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPAD 779

Query: 909  GF----KSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRD 964
             F    KSP  ++ K  E  KS +  +   P+   E P      +   +K+  + + ++ 
Sbjct: 780  KFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEK--EIP------KKEEVKS-PVKEEEKP 830

Query: 965  KDGNVTQETKKMEMK---GEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDRE 1021
            ++  V +  KK E +     PK + +K    E+  K   P   +++     V+K  + + 
Sbjct: 831  QEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKV 890

Query: 1022 DKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNE 1081
            +  +   +  K  P+   +      V ++  P+   E+    P   + K   +       
Sbjct: 891  EAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEA 950

Query: 1082 KPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAW-------EYEERDRRSSGDHRRS 1131
             P+  +   ++    +E  ++  K   K+DDK         + E+ ++ SS D + S
Sbjct: 951  APEKKDTKEEKAKKPEEKPKTEAK--AKEDDKTLSKEPSKPKAEKAEKSSSTDQKDS 1005



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 129/647 (19%), Positives = 240/647 (37%), Gaps = 68/647 (10%)

Query: 302  LPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLR 361
            +P S P  +P  I   S   K K ++K+K+     E+SEK     +I     + T++T  
Sbjct: 418  IPFSLPEGLPK-IPSVSTHIKVKSEEKIKV----VEKSEKET---VIVEEQTEETQVTEE 469

Query: 362  LSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLS 421
            ++     +  ++E    G E     E +        G   +T   P         A+  +
Sbjct: 470  VTEEEEKEAKEEE----GKEEEGGEEEEAE------GGEEETKSPP---------AEEAA 510

Query: 422  QQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIE 481
              E+ A  P  +    +  +   AK P+    ++  ++          + +A +  E   
Sbjct: 511  SPEKEAKSPVKE----EAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKS 566

Query: 482  RESAIERERFSKEVQDKDKPLKKRKQDSY-PQEAGGATGGNRPASQETGSTGNGSRPALM 540
             E   E  +   EV+  +K     K+++  P EA        P  +E  S      P   
Sbjct: 567  PEK--EEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSP--- 621

Query: 541  VSIDLHQAGRVDS-QASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPET 599
            V  +      V S + + +   +  K PE+ K          ++      KS  +   ++
Sbjct: 622  VKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEK-----AKSPVKAEAKS 676

Query: 600  PKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTT 659
            P+K   P   K+E K  E   +  K  E +  E   S  K E K   + +   + E++T 
Sbjct: 677  PEKAKSPV--KAEAKSPEKAKSPVK-EEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTP 733

Query: 660  ECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSET-TKSRPETPKQKGESRPETPKQKS 718
            E K       E K  E   S  K       +  ++T  K    +P  K   + ++P ++ 
Sbjct: 734  E-KAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEE 792

Query: 719  DGHPETPKQ--KGDGRP---ETPKQKGESRPETPKQK-NEGRPETPKHRHDNRRDSGKPS 772
               PE  K   K D +    E PK++    P   ++K  E + + P  + +  +    P 
Sbjct: 793  VKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPK 852

Query: 773  TEKKPEVSKHKQDTKSDSPRLK-SERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESE 831
            TE+K + SK ++  K ++P+ K  E+ E   ++P    V        D K+      E+ 
Sbjct: 853  TEEKKD-SKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAP 911

Query: 832  RHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPD 891
                  ++V   E  +   + E   K       K   K   +   + E+  + E+K++  
Sbjct: 912  ------AKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAK-- 963

Query: 892  SPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNK 938
             P  K     K++ D        SK+  + +  K++  ++    D+K
Sbjct: 964  KPEEKPKTEAKAKEDD----KTLSKEPSKPKAEKAEKSSSTDQKDSK 1006



 Score = 66.2 bits (160), Expect = 4e-10
 Identities = 97/500 (19%), Positives = 194/500 (38%), Gaps = 43/500 (8%)

Query: 318  SPERKQKKQKKMKLGKDEKEQS---EKAAMYDIISSPSKDSTKLTLRLSRVRSSDMDQQE 374
            SPE+++ K    ++   EK +S   E+A       SP K+  K    +     +    +E
Sbjct: 532  SPEKEEAKSPA-EVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKE 590

Query: 375  DMISGVENSNVSENDIPFNVQYPGQT-SKTPI-----TPQDINRPLNAAQCLSQQEQTAF 428
            +  S  E  +  +   P   +      +K+P+     +P ++  P   A+  +++E  + 
Sbjct: 591  EAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSP-EKAKSPTKEEAKSP 649

Query: 429  LPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIER 488
              A      +  +   AK P  +  ++ ++   + P+  E +    A+     +E A   
Sbjct: 650  EKAKSPEKEEAKSPEKAKSPVKAEAKSPEKA--KSPVKAEAKSPEKAKSP--VKEEAKSP 705

Query: 489  ERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQA 548
            E+    V+++ K  +K K     +EA        P  +E  S      P    ++D+   
Sbjct: 706  EKAKSPVKEEAKSPEKAKSP-VKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSP 764

Query: 549  -----GRVDSQASITQDSDSIKKP--EEIKQCNDAPVSVLQEDIVGSLKSTP-------- 593
                  + ++++   +  +  K P  EE+K    A  S L+ED     K  P        
Sbjct: 765  EAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAK-SPLKEDAKAPEKEIPKKEEVKSP 823

Query: 594  ---ENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSEN-KLETKVETQTE 649
               E  P+  K K  P+ ++ E   +  +  E K ++      K +   K+E K E   E
Sbjct: 824  VKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVE 883

Query: 650  ELKQNESRTTECKQNESTIVE--PKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKG 707
            + K+++    E K+ E+   +  P   +   +  +  ++ +   ++E  K  P+  K K 
Sbjct: 884  KPKESK---VEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKE 940

Query: 708  ESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRD 767
             S+P   K+ +    +T ++K     E PK + +++ +      E  P  PK     +  
Sbjct: 941  PSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKE--PSKPKAEKAEKSS 998

Query: 768  SGKPSTEKKPEVSKHKQDTK 787
            S      K PE +   +  K
Sbjct: 999  STDQKDSKPPEKATEDKAAK 1018



 Score = 52.4 bits (124), Expect = 6e-06
 Identities = 83/480 (17%), Positives = 170/480 (35%), Gaps = 42/480 (8%)

Query: 272  LRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKL 331
            ++SP+   SPA  E       PP     +     SP +V       SP +++ K    + 
Sbjct: 544  VKSPEKAKSPAKEEA----KSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPA-EA 598

Query: 332  GKDEKEQS---EKAAMYDIISSPSKDSTKLTLRLSRVRSSDMDQQEDMISGVENSNVSEN 388
               EK +S   E+A       SP K+  K    +     +    +E+  S  +  +  + 
Sbjct: 599  KSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKE 658

Query: 389  DIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQP 448
            +     +          +P+    P+ A    ++  + A  P  +     +      K+ 
Sbjct: 659  EAKSPEKAKSPVKAEAKSPEKAKSPVKAE---AKSPEKAKSPVKEEAKSPEKAKSPVKEE 715

Query: 449  QTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERF----SKEVQDKDKPLKK 504
              S  + +  + ++    ++ +     E +  E+  + E+ +     S E +   K   +
Sbjct: 716  AKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEAR 775

Query: 505  RKQDSYPQEAGGATGGNRPASQETGSTGNGSRP----ALMVSIDLHQAGRVDSQASITQD 560
               D +P++A        P  +E  S      P    A     ++ +   V S     + 
Sbjct: 776  SPADKFPEKA------KSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEK 829

Query: 561  SDSIKKPEEIKQCND--APVSVLQEDIVGSLKS-TPENHPETPK--KKSDPELSKSEMKQ 615
               +K  E  K+  +  AP +   E+   S K   P+     PK  +K +P + K +  +
Sbjct: 830  PQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESK 889

Query: 616  SESRLAESKPNENRLVETKSSENKLETKVETQTEELKQ------------NESRTTECKQ 663
             E++  E++  +      K +  K+E K + + +E  +              S+  E K+
Sbjct: 890  VEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKE 949

Query: 664  NESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPE 723
                  + K+ + +  + KP    +     +T    P  PK +   +  +  QK    PE
Sbjct: 950  AAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPE 1009



 Score = 50.1 bits (118), Expect = 3e-05
 Identities = 87/448 (19%), Positives = 170/448 (37%), Gaps = 45/448 (10%)

Query: 775  KKPEVSKHKQDTKSDSPRL--KSERAEAL-KQRPDGRSVSESLRRDHDNKQKSDDR---- 827
            K P VS H +    +  ++  KSE+   + +++ +   V+E +  + + + K ++     
Sbjct: 428  KIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEE 487

Query: 828  -GESERHRGDQSRVRRPETLRSSS---------RNEHGIKSDSSKTDKLERKHRHE--SG 875
             GE E   G +   + P    ++S         + E    +++   +K E K   E  S 
Sbjct: 488  GGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSP 547

Query: 876  DSRERPSSGEQKSRPD--SPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKA 933
            +  + P+  E KS P+  SP  ++  S          KSP +K++ ++       +  K+
Sbjct: 548  EKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSP-AKEEAKSPAEAKSPEKAKS 606

Query: 934  HPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVE 993
                +A+ P+          K+    K   +K  + T+E  K   K +  +K E     +
Sbjct: 607  PVKEEAKSPAEAKSPVKEEAKSPAEVK-SPEKAKSPTKEEAKSPEKAKSPEKEE----AK 661

Query: 994  DLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPP 1053
               K   PV    K S +  +  +K        +  P+K +     K         + P 
Sbjct: 662  SPEKAKSPVKAEAK-SPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPE 720

Query: 1054 ELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDK 1113
            +  + ++      E+ K   ++ +   EK K  E +   D  S EA   +++  +   DK
Sbjct: 721  KAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADK 780

Query: 1114 AWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPP-PSLSEVARKM 1172
               + E+ +    +  +S               + +SP   D +      P   EV   +
Sbjct: 781  ---FPEKAKSPVKEEVKSPE-------------KAKSPLKEDAKAPEKEIPKKEEVKSPV 824

Query: 1173 KKKEKQKKRKAYEPKLTPEEMMDSSTFK 1200
            K++EK ++ K  EP    EE    +T K
Sbjct: 825  KEEEKPQEVKVKEPPKKAEEEKAPATPK 852



 Score = 49.3 bits (116), Expect = 5e-05
 Identities = 106/579 (18%), Positives = 219/579 (37%), Gaps = 97/579 (16%)

Query: 109  EKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMP 168
            EK  ++   +     ++ K  +     SPA     +   S +      PP+  S  +   
Sbjct: 513  EKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEA 572

Query: 169  QQNSPVPSPYAPQSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLS 228
            +  + V SP   +SPA                   A   SP            K   P+ 
Sbjct: 573  KSPAEVKSPEKAKSPA------------KEEAKSPAEAKSP-----------EKAKSPV- 608

Query: 229  GNSANHHADNPRHGSS---EDYLHMVHRLSSDDGDSSTMRNAASFPLRSPQPVCSPAGSE 285
                   A +P    S   E+        S +   S T   A     +SP+   SP   E
Sbjct: 609  ----KEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEA-----KSPEKAKSPEKEE 659

Query: 286  G-TPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLG-KDEKEQSEKAA 343
              +P+ ++ P+  +++S          P+      + + K  +K K   K+E +  EKA 
Sbjct: 660  AKSPEKAKSPVKAEAKS----------PEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKA- 708

Query: 344  MYDIISSPSKDSTKLTLRLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKT 403
                  SP K+  K   +       +    E   S V+    S            + +K+
Sbjct: 709  -----KSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSP-----------EKAKS 752

Query: 404  PITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQG 463
            P   + ++  + + +  +  ++ A  PA++ P         AK P    V++ ++   + 
Sbjct: 753  PEKAKTLD--VKSPEAKTPAKEEARSPADKFP-------EKAKSPVKEEVKSPEK--AKS 801

Query: 464  PIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRP 523
            P+ ++ +       ++ E +S ++ E   +EV+ K+ P KK +++  P  A   T   + 
Sbjct: 802  PLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPP-KKAEEEKAP--ATPKTEEKKD 858

Query: 524  ASQETGSTGNGSRPAL----MVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVS 579
            + +E        +P +      +++  +  +V+++    +D   +  PE+     +AP  
Sbjct: 859  SKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEK-----EAPAK 913

Query: 580  V-LQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSEN 638
            V ++ED      + P+   E  KK+ D   +K   K +E + A  +  + +  + K  E 
Sbjct: 914  VEVKED------AKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEE 967

Query: 639  KLETKVETQTEE--LKQNESRTTECKQNESTIVEPKQNE 675
            K +T+ + + ++  L +  S+    K  +S+  + K ++
Sbjct: 968  KPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSK 1006


>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sapiens]
          Length = 1758

 Score = 81.6 bits (200), Expect = 1e-14
 Identities = 140/697 (20%), Positives = 273/697 (39%), Gaps = 105/697 (15%)

Query: 582  QEDIVGSL----KSTPENHPETPKKK---SDPELSKSEMKQSESRLAESKPNENRLVETK 634
            +ED VG      ++   N+PE    +   +  + +KS+ K+SE+   + K N+++    +
Sbjct: 846  REDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKR 905

Query: 635  SSENKLETKVETQTEELKQNESRTTECKQN--ESTIVEPKQNENRLSDTKPNDNKQNNGR 692
                + E  +  +  E  +     T  ++N  +S  V P +++      +P D +    +
Sbjct: 906  RKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFK 965

Query: 693  SETTKSRPET--PKQKGESRPETPKQKSDGH-----------PETPKQKGDG-RPETPKQ 738
            S + K + E   PK KG+      K+K+DG             + P++K DG R  +P+ 
Sbjct: 966  SVSEKDKRERDKPKAKGDK----TKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRS 1021

Query: 739  K---GESRPETPK----------QKNEGRPETPKHRHDNRRDSGKPSTEKKP-EVSKHKQ 784
            +    +++ ETPK          QK+E    TP+  H     S K   E KP +  K K+
Sbjct: 1022 EPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSK---SAKEHQETKPVKEEKVKK 1078

Query: 785  DTKSD--SPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRR 842
            D   D  S +L ++  +A K     + +     +    K+K++++G  +       ++ +
Sbjct: 1079 DYSKDVKSEKLTTKEEKAKKPNEKNKPLD---NKGEKRKRKTEEKGVDKDFESSSMKISK 1135

Query: 843  ---PETLRSSSRNEHGIKSDSSKTD-----------------KLERKHRHESGDSRERPS 882
                E ++ S + +  ++ D+ K D                 KL R+   + G +    +
Sbjct: 1136 LEVTEIVKPSPKRK--MEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISN 1193

Query: 883  SGE--QKSRPDSPRVKQ-----------GDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVD 929
            + E  +K    S +VKQ             +  S S  + + S +S        ++ K D
Sbjct: 1194 TKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTD 1253

Query: 930  TNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQE-----TKKMEMKGEPKD 984
            T +       E+ +         +    +P+ K DKD   ++E     T+ +   G+P  
Sbjct: 1254 TKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPAS 1313

Query: 985  KVEKI-----GLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSN 1039
             ++ +      +V+   K ++P   +QK + D   ++I+     S++S    K K     
Sbjct: 1314 VIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDR- 1372

Query: 1040 KGSIDQSVLKELPPELLAEIESTMPLCER--VKMNKRKR-STVNEKPKYAEISSDEDND- 1095
                D SVL++  PE      ST P  E    ++N++    ++++  K A  S   D+  
Sbjct: 1373 ----DYSVLEKENPE--KRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTR 1426

Query: 1096 SDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSD 1155
            +    + +  R KK D    EY    RR   +          R        +N+   + D
Sbjct: 1427 ASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERD 1486

Query: 1156 MEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEE 1192
            +       S    +   + ++    +  Y+ K   EE
Sbjct: 1487 LPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEE 1523



 Score = 75.1 bits (183), Expect = 9e-13
 Identities = 163/782 (20%), Positives = 310/782 (39%), Gaps = 110/782 (14%)

Query: 478  ERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRP 537
            E ++ ES   +    K+ +++DKP  K K D   ++  G+       S++         P
Sbjct: 955  EPMDAESITFKSVSEKDKRERDKP--KAKGDKTKRKNDGSA-----VSKKENIVKPAKGP 1007

Query: 538  ALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGS-----LKST 592
               V  +  ++ R  S+  I +  +   K +  K  +    S   E I G+      KS 
Sbjct: 1008 QEKVDGERERSPR--SEPPIKKAKEETPKTDNTKSSSS---SQKDEKITGTPRKAHSKSA 1062

Query: 593  PENHPETPKKKSDPELSKSEMKQSESRLAES----KPNE-NRLVETKSSENKLETKVETQ 647
             E+    P K+   +   S+  +SE    +     KPNE N+ ++ K  + K +T+ +  
Sbjct: 1063 KEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGV 1122

Query: 648  TEELKQNESRTTECKQNESTIVEPKQ----NENRLSDTKPNDNKQNNGRSETTKSRPETP 703
             ++ + +  + ++ +  E     PK+    +  ++  T   D    +  ++  K   ET 
Sbjct: 1123 DKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETG 1182

Query: 704  KQKGE----SRPETPKQKSDGHPETPKQ---KGDGRPETPKQKGESRP-----------E 745
            K+ G     S  + P +K +      KQ   KG  R +    +G S              
Sbjct: 1183 KKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGG 1242

Query: 746  TPKQKNEGRPETP----KHRHDNRRDSGKPSTE-----KKPEVSKHKQDTKSDSPRLKSE 796
            +P +K+E + +T     K   +   D+  P+ +     + P+    K D +S+   +KS 
Sbjct: 1243 SPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKST 1302

Query: 797  RAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGI 856
            +  +   +P   SV +++     N  K  ++ ESE       ++++     S    +H +
Sbjct: 1303 QPISSVGKP--ASVIKNVSTKPSNIVKYPEK-ESE----PSEKIQKFTKDVSHEIIQHEV 1355

Query: 857  KS--DSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLG-FKS- 912
            KS  +S+ ++K + K R  S   +E P   +  ++P+       +SN  R ++ G FKS 
Sbjct: 1356 KSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEK------ESNLDRLNEQGNFKSL 1409

Query: 913  -PTSKDDKRTEGNKS-KVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVT 970
              +SK+ + ++ + S +  +NK    N+ +   Y     S + +     ++ R KD    
Sbjct: 1410 SQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSR 1469

Query: 971  QETKKMEMKGEPKDK--VEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSL 1028
             +      K +P+++  + K G  +     + P    +           +  E+      
Sbjct: 1470 NKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDK 1529

Query: 1029 KPIKNKP-----SKSNKGSIDQSVLKEL-PPELLAEIESTMPLCERVKMNKRKRSTVNEK 1082
             P K++      +++NK S    +L  L PPE   E E      ++        STV  K
Sbjct: 1530 NPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDK--------STVKPK 1581

Query: 1083 PKYAE---ISSDEDNDSDEA-FESSRKRHKKDDDKAWEYEERDRRSSGDHR--------- 1129
            P+ +    +SSD   ++DEA FE        + + + + EE     S D +         
Sbjct: 1582 PQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKE 1641

Query: 1130 --------RSGHSHEGRRSSGG-GRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKK 1180
                    + G S     SS      R+ SPS S    +S   S +E     KKK+K++K
Sbjct: 1642 SLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEK 1701

Query: 1181 RK 1182
            +K
Sbjct: 1702 KK 1703



 Score = 72.4 bits (176), Expect = 6e-12
 Identities = 151/849 (17%), Positives = 314/849 (36%), Gaps = 119/849 (14%)

Query: 381  ENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQN 440
            E + V EN        P +   TP+  + ++      + +S++++            ++ 
Sbjct: 928  EPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDK------------RER 975

Query: 441  TSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERI--ERESAIERERFSKEVQDK 498
                AK  +T    +   +S++    + +   A    E++  ERE +   E   K+ +++
Sbjct: 976  DKPKAKGDKTKRKNDGSAVSKK----ENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEE 1031

Query: 499  DKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQAGRVDSQASIT 558
                   K  S  Q+    TG  R A  ++      ++P     +    +  V S+  +T
Sbjct: 1032 TPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSE-KLT 1090

Query: 559  QDSDSIKKPEEI---------------------KQCNDAPVSVLQEDIVGSLKSTPEN-- 595
               +  KKP E                      K    + + + + ++   +K +P+   
Sbjct: 1091 TKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKM 1150

Query: 596  HPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLET--KVETQTEELKQ 653
             P+T K    PE  K  +     ++  ++    ++  T++  N  E   K+E+ + ++KQ
Sbjct: 1151 EPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQ 1210

Query: 654  NE------SRTTECKQNESTIVE----------PKQNENRLSDTK-------PNDNKQNN 690
             +       + T  + + ST+V+          P +     +DTK          N  N 
Sbjct: 1211 EKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNT 1270

Query: 691  GRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPET---- 746
              +E      + P+ K +   +  + + +    T      G+P +  +   ++P      
Sbjct: 1271 APAEDVIIMIQVPQSKWDK--DDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKY 1328

Query: 747  PKQKNEGRPETPKHRHDNRRDSGKPSTEK-KPEVSKHKQDTKS-DSPRLKSERAEALKQ- 803
            P++++E   +  K   D   +  +   +  K   S  K  TK  D   L+ E  E  K  
Sbjct: 1329 PEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNS 1388

Query: 804  -RPDGRSVSESLRRDHDNK---QKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIK-- 857
             +P+  S  + L    + K   Q S +   S++H   ++   +  T     + ++  +  
Sbjct: 1389 TQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREY 1448

Query: 858  SDSSKTDKLERKHRHESGDSRERPSSGEQKSRP----DSPRVKQGDSNKSRSDKLGFKSP 913
            S S + D+     R +   SR + S+  QK++P    D P+   GDS KS S     + P
Sbjct: 1449 SSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKP 1508

Query: 914  ----TSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVI--PKIKRDKDG 967
                 + D KR       VD N      K    +      SG    +++  P+ + +K+ 
Sbjct: 1509 HDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKE- 1567

Query: 968  NVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSS 1027
             +T +  K  +K +P+       L  DL +           +  D +  +  +E++S  +
Sbjct: 1568 QITGQIDKSTVKPKPQLS-HSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGN 1626

Query: 1028 L-KPIKNKPSKSNKGSIDQSVLKEL---------PPELL---------------AEIEST 1062
            + K +K+K  +  K S+D + + ++          P +                +   S+
Sbjct: 1627 ISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASS 1686

Query: 1063 MPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDR 1122
                +  K  K+K    ++K K  +          E  +S + +HKK   K  + +E+++
Sbjct: 1687 AESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEK 1746

Query: 1123 RSSGDHRRS 1131
                   +S
Sbjct: 1747 EKDDQKVKS 1755



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 155/797 (19%), Positives = 317/797 (39%), Gaps = 118/797 (14%)

Query: 307  PRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRVR 366
            P   P + +    ER  + +  +K  K+E  +++        SS S+   K+T    +  
Sbjct: 1003 PAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKS----SSSSQKDEKITGTPRKAH 1058

Query: 367  SSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPIT--PQDINRPLN--------- 415
            S    + ++    V+   V + D   +V+    T+K      P + N+PL+         
Sbjct: 1059 SKSAKEHQET-KPVKEEKVKK-DYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRK 1116

Query: 416  -AAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDAL 474
               + + +  +++ +  +++ V    T +    P+  +  + +++ +  P  D++ L A 
Sbjct: 1117 TEEKGVDKDFESSSMKISKLEV----TEIVKPSPKRKMEPDTEKMDRT-PEKDKISLSAP 1171

Query: 475  AEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNG 534
            A+  ++ RE+  ++   ++ + +  +P +K +  S   +     G  R   + TG+ G+ 
Sbjct: 1172 AKKIKLNRETG-KKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVR--RKVTGTEGSS 1228

Query: 535  SRPALMVSIDLHQAGRVDSQASITQDSDS-IKKPEEIKQCNDAPVSVLQEDIVGSLKSTP 593
            S      S        V      T    + IK  EE    N AP     ED++  ++   
Sbjct: 1229 STLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPA----EDVIIMIQV-- 1282

Query: 594  ENHPETPKKKSDPELSKSEMKQSESRLAESKP---------NENRLVETKSSENKLETKV 644
               P++   K D E  + ++K ++   +  KP           + +V+    E++   K+
Sbjct: 1283 ---PQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKI 1339

Query: 645  ETQTE----ELKQNESRTTE---------CKQNESTIVEPKQNENRLSDTKPND------ 685
            +  T+    E+ Q+E ++++          K  + +++E +  E R + T+P        
Sbjct: 1340 QKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDR 1399

Query: 686  -NKQNNGRSETTKSRPETPKQKGES------RPETP----KQKSDGHPETPKQKGDGRPE 734
             N+Q N +S +  S+      K +S      +  TP    K   D    +  ++ D + E
Sbjct: 1400 LNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNE 1459

Query: 735  TPKQK---GESRPETPKQKNEGRPETP---KHRHDNRRDSGKPSTEKKPEVSKHKQDTKS 788
              ++K     ++     QKN+ R E     K   D+++ +  PS ++KP   K   DTK 
Sbjct: 1460 LTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKR 1519

Query: 789  DSPRLKSERAEALKQRPDGRSVSESLRRDHDNK-----QKSDDRGESERHRG--DQSRVR 841
             +   KS      K R      + + +    NK        + + E E+  G  D+S V+
Sbjct: 1520 PNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVK 1579

Query: 842  RPETLRSSSRNEHGIKSD-SSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS 900
                L  SSR    + SD + +TD+   +  +   DS    S  E++S         G+ 
Sbjct: 1580 PKPQLSHSSR----LSSDLTRETDEAAFEPDYNESDSESNVSVKEEES--------SGNI 1627

Query: 901  NKSRSDKLGFKSPTSKDD--------KRTEGNKS-KVDTNKAHPDNKAEFPSYLLGGRSG 951
            +K   DK+  K+  S D          R + + S  V  +++H  + ++  S+     S 
Sbjct: 1628 SKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSA 1687

Query: 952  ALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLD 1011
              ++    K K++K        KK +   + K   +  G   +L K  K     +K   +
Sbjct: 1688 ESQDSKKKKKKKEK--------KKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKN 1739

Query: 1012 DVQKLIKDREDKSRSSL 1028
              ++  K+++D+   S+
Sbjct: 1740 KDKEKEKEKDDQKVKSV 1756



 Score = 33.9 bits (76), Expect = 2.3
 Identities = 27/105 (25%), Positives = 43/105 (40%), Gaps = 8/105 (7%)

Query: 124 SQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQT--SSGNRFMPQQNSPVPSPYAPQ 181
           S Y+      H S  S   Q  ++  +P    VPP          +P      P  ++PQ
Sbjct: 527 SCYRSINRGRHHSERSQRTQGPSLPATPVFVPVPPPPLYPPPPHTLPLPPGVPPPQFSPQ 586

Query: 182 SPAGYMPYSHPSSYTTHPQ---MQQASVSSPIVAGGLRNIHDNKV 223
            P G  P   P+ Y+  P       A++S+P V+ G++  H N +
Sbjct: 587 FPPGQPP---PAGYSVPPPGFPPAPANLSTPWVSSGVQTAHSNTI 628


>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sapiens]
          Length = 1792

 Score = 81.6 bits (200), Expect = 1e-14
 Identities = 140/697 (20%), Positives = 273/697 (39%), Gaps = 105/697 (15%)

Query: 582  QEDIVGSL----KSTPENHPETPKKK---SDPELSKSEMKQSESRLAESKPNENRLVETK 634
            +ED VG      ++   N+PE    +   +  + +KS+ K+SE+   + K N+++    +
Sbjct: 880  REDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKR 939

Query: 635  SSENKLETKVETQTEELKQNESRTTECKQN--ESTIVEPKQNENRLSDTKPNDNKQNNGR 692
                + E  +  +  E  +     T  ++N  +S  V P +++      +P D +    +
Sbjct: 940  RKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFK 999

Query: 693  SETTKSRPET--PKQKGESRPETPKQKSDGH-----------PETPKQKGDG-RPETPKQ 738
            S + K + E   PK KG+      K+K+DG             + P++K DG R  +P+ 
Sbjct: 1000 SVSEKDKRERDKPKAKGDK----TKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRS 1055

Query: 739  K---GESRPETPK----------QKNEGRPETPKHRHDNRRDSGKPSTEKKP-EVSKHKQ 784
            +    +++ ETPK          QK+E    TP+  H     S K   E KP +  K K+
Sbjct: 1056 EPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSK---SAKEHQETKPVKEEKVKK 1112

Query: 785  DTKSD--SPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRR 842
            D   D  S +L ++  +A K     + +     +    K+K++++G  +       ++ +
Sbjct: 1113 DYSKDVKSEKLTTKEEKAKKPNEKNKPLD---NKGEKRKRKTEEKGVDKDFESSSMKISK 1169

Query: 843  ---PETLRSSSRNEHGIKSDSSKTD-----------------KLERKHRHESGDSRERPS 882
                E ++ S + +  ++ D+ K D                 KL R+   + G +    +
Sbjct: 1170 LEVTEIVKPSPKRK--MEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISN 1227

Query: 883  SGE--QKSRPDSPRVKQ-----------GDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVD 929
            + E  +K    S +VKQ             +  S S  + + S +S        ++ K D
Sbjct: 1228 TKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTD 1287

Query: 930  TNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQE-----TKKMEMKGEPKD 984
            T +       E+ +         +    +P+ K DKD   ++E     T+ +   G+P  
Sbjct: 1288 TKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPAS 1347

Query: 985  KVEKI-----GLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSN 1039
             ++ +      +V+   K ++P   +QK + D   ++I+     S++S    K K     
Sbjct: 1348 VIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDR- 1406

Query: 1040 KGSIDQSVLKELPPELLAEIESTMPLCER--VKMNKRKR-STVNEKPKYAEISSDEDND- 1095
                D SVL++  PE      ST P  E    ++N++    ++++  K A  S   D+  
Sbjct: 1407 ----DYSVLEKENPE--KRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTR 1460

Query: 1096 SDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSD 1155
            +    + +  R KK D    EY    RR   +          R        +N+   + D
Sbjct: 1461 ASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERD 1520

Query: 1156 MEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEE 1192
            +       S    +   + ++    +  Y+ K   EE
Sbjct: 1521 LPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEE 1557



 Score = 75.1 bits (183), Expect = 9e-13
 Identities = 163/782 (20%), Positives = 310/782 (39%), Gaps = 110/782 (14%)

Query: 478  ERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRP 537
            E ++ ES   +    K+ +++DKP  K K D   ++  G+       S++         P
Sbjct: 989  EPMDAESITFKSVSEKDKRERDKP--KAKGDKTKRKNDGSA-----VSKKENIVKPAKGP 1041

Query: 538  ALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGS-----LKST 592
               V  +  ++ R  S+  I +  +   K +  K  +    S   E I G+      KS 
Sbjct: 1042 QEKVDGERERSPR--SEPPIKKAKEETPKTDNTKSSSS---SQKDEKITGTPRKAHSKSA 1096

Query: 593  PENHPETPKKKSDPELSKSEMKQSESRLAES----KPNE-NRLVETKSSENKLETKVETQ 647
             E+    P K+   +   S+  +SE    +     KPNE N+ ++ K  + K +T+ +  
Sbjct: 1097 KEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGV 1156

Query: 648  TEELKQNESRTTECKQNESTIVEPKQ----NENRLSDTKPNDNKQNNGRSETTKSRPETP 703
             ++ + +  + ++ +  E     PK+    +  ++  T   D    +  ++  K   ET 
Sbjct: 1157 DKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETG 1216

Query: 704  KQKGE----SRPETPKQKSDGHPETPKQ---KGDGRPETPKQKGESRP-----------E 745
            K+ G     S  + P +K +      KQ   KG  R +    +G S              
Sbjct: 1217 KKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGG 1276

Query: 746  TPKQKNEGRPETP----KHRHDNRRDSGKPSTE-----KKPEVSKHKQDTKSDSPRLKSE 796
            +P +K+E + +T     K   +   D+  P+ +     + P+    K D +S+   +KS 
Sbjct: 1277 SPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKST 1336

Query: 797  RAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGI 856
            +  +   +P   SV +++     N  K  ++ ESE       ++++     S    +H +
Sbjct: 1337 QPISSVGKP--ASVIKNVSTKPSNIVKYPEK-ESE----PSEKIQKFTKDVSHEIIQHEV 1389

Query: 857  KS--DSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLG-FKS- 912
            KS  +S+ ++K + K R  S   +E P   +  ++P+       +SN  R ++ G FKS 
Sbjct: 1390 KSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEK------ESNLDRLNEQGNFKSL 1443

Query: 913  -PTSKDDKRTEGNKS-KVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVT 970
              +SK+ + ++ + S +  +NK    N+ +   Y     S + +     ++ R KD    
Sbjct: 1444 SQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSR 1503

Query: 971  QETKKMEMKGEPKDK--VEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSL 1028
             +      K +P+++  + K G  +     + P    +           +  E+      
Sbjct: 1504 NKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDK 1563

Query: 1029 KPIKNKP-----SKSNKGSIDQSVLKEL-PPELLAEIESTMPLCERVKMNKRKRSTVNEK 1082
             P K++      +++NK S    +L  L PPE   E E      ++        STV  K
Sbjct: 1564 NPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDK--------STVKPK 1615

Query: 1083 PKYAE---ISSDEDNDSDEA-FESSRKRHKKDDDKAWEYEERDRRSSGDHR--------- 1129
            P+ +    +SSD   ++DEA FE        + + + + EE     S D +         
Sbjct: 1616 PQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKE 1675

Query: 1130 --------RSGHSHEGRRSSGG-GRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKK 1180
                    + G S     SS      R+ SPS S    +S   S +E     KKK+K++K
Sbjct: 1676 SLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEK 1735

Query: 1181 RK 1182
            +K
Sbjct: 1736 KK 1737



 Score = 72.4 bits (176), Expect = 6e-12
 Identities = 151/849 (17%), Positives = 314/849 (36%), Gaps = 119/849 (14%)

Query: 381  ENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQN 440
            E + V EN        P +   TP+  + ++      + +S++++            ++ 
Sbjct: 962  EPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDK------------RER 1009

Query: 441  TSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERI--ERESAIERERFSKEVQDK 498
                AK  +T    +   +S++    + +   A    E++  ERE +   E   K+ +++
Sbjct: 1010 DKPKAKGDKTKRKNDGSAVSKK----ENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEE 1065

Query: 499  DKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQAGRVDSQASIT 558
                   K  S  Q+    TG  R A  ++      ++P     +    +  V S+  +T
Sbjct: 1066 TPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSE-KLT 1124

Query: 559  QDSDSIKKPEEI---------------------KQCNDAPVSVLQEDIVGSLKSTPEN-- 595
               +  KKP E                      K    + + + + ++   +K +P+   
Sbjct: 1125 TKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKM 1184

Query: 596  HPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLET--KVETQTEELKQ 653
             P+T K    PE  K  +     ++  ++    ++  T++  N  E   K+E+ + ++KQ
Sbjct: 1185 EPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQ 1244

Query: 654  NE------SRTTECKQNESTIVE----------PKQNENRLSDTK-------PNDNKQNN 690
             +       + T  + + ST+V+          P +     +DTK          N  N 
Sbjct: 1245 EKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNT 1304

Query: 691  GRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPET---- 746
              +E      + P+ K +   +  + + +    T      G+P +  +   ++P      
Sbjct: 1305 APAEDVIIMIQVPQSKWDK--DDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKY 1362

Query: 747  PKQKNEGRPETPKHRHDNRRDSGKPSTEK-KPEVSKHKQDTKS-DSPRLKSERAEALKQ- 803
            P++++E   +  K   D   +  +   +  K   S  K  TK  D   L+ E  E  K  
Sbjct: 1363 PEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNS 1422

Query: 804  -RPDGRSVSESLRRDHDNK---QKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIK-- 857
             +P+  S  + L    + K   Q S +   S++H   ++   +  T     + ++  +  
Sbjct: 1423 TQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREY 1482

Query: 858  SDSSKTDKLERKHRHESGDSRERPSSGEQKSRP----DSPRVKQGDSNKSRSDKLGFKSP 913
            S S + D+     R +   SR + S+  QK++P    D P+   GDS KS S     + P
Sbjct: 1483 SSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKP 1542

Query: 914  ----TSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVI--PKIKRDKDG 967
                 + D KR       VD N      K    +      SG    +++  P+ + +K+ 
Sbjct: 1543 HDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKE- 1601

Query: 968  NVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSS 1027
             +T +  K  +K +P+       L  DL +           +  D +  +  +E++S  +
Sbjct: 1602 QITGQIDKSTVKPKPQLS-HSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGN 1660

Query: 1028 L-KPIKNKPSKSNKGSIDQSVLKEL---------PPELL---------------AEIEST 1062
            + K +K+K  +  K S+D + + ++          P +                +   S+
Sbjct: 1661 ISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASS 1720

Query: 1063 MPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDR 1122
                +  K  K+K    ++K K  +          E  +S + +HKK   K  + +E+++
Sbjct: 1721 AESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEK 1780

Query: 1123 RSSGDHRRS 1131
                   +S
Sbjct: 1781 EKDDQKVKS 1789



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 155/797 (19%), Positives = 317/797 (39%), Gaps = 118/797 (14%)

Query: 307  PRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRVR 366
            P   P + +    ER  + +  +K  K+E  +++        SS S+   K+T    +  
Sbjct: 1037 PAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKS----SSSSQKDEKITGTPRKAH 1092

Query: 367  SSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPIT--PQDINRPLN--------- 415
            S    + ++    V+   V + D   +V+    T+K      P + N+PL+         
Sbjct: 1093 SKSAKEHQET-KPVKEEKVKK-DYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRK 1150

Query: 416  -AAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDAL 474
               + + +  +++ +  +++ V    T +    P+  +  + +++ +  P  D++ L A 
Sbjct: 1151 TEEKGVDKDFESSSMKISKLEV----TEIVKPSPKRKMEPDTEKMDRT-PEKDKISLSAP 1205

Query: 475  AEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNG 534
            A+  ++ RE+  ++   ++ + +  +P +K +  S   +     G  R   + TG+ G+ 
Sbjct: 1206 AKKIKLNRETG-KKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVR--RKVTGTEGSS 1262

Query: 535  SRPALMVSIDLHQAGRVDSQASITQDSDS-IKKPEEIKQCNDAPVSVLQEDIVGSLKSTP 593
            S      S        V      T    + IK  EE    N AP     ED++  ++   
Sbjct: 1263 STLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPA----EDVIIMIQV-- 1316

Query: 594  ENHPETPKKKSDPELSKSEMKQSESRLAESKP---------NENRLVETKSSENKLETKV 644
               P++   K D E  + ++K ++   +  KP           + +V+    E++   K+
Sbjct: 1317 ---PQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKI 1373

Query: 645  ETQTE----ELKQNESRTTE---------CKQNESTIVEPKQNENRLSDTKPND------ 685
            +  T+    E+ Q+E ++++          K  + +++E +  E R + T+P        
Sbjct: 1374 QKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDR 1433

Query: 686  -NKQNNGRSETTKSRPETPKQKGES------RPETP----KQKSDGHPETPKQKGDGRPE 734
             N+Q N +S +  S+      K +S      +  TP    K   D    +  ++ D + E
Sbjct: 1434 LNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNE 1493

Query: 735  TPKQK---GESRPETPKQKNEGRPETP---KHRHDNRRDSGKPSTEKKPEVSKHKQDTKS 788
              ++K     ++     QKN+ R E     K   D+++ +  PS ++KP   K   DTK 
Sbjct: 1494 LTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKR 1553

Query: 789  DSPRLKSERAEALKQRPDGRSVSESLRRDHDNK-----QKSDDRGESERHRG--DQSRVR 841
             +   KS      K R      + + +    NK        + + E E+  G  D+S V+
Sbjct: 1554 PNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVK 1613

Query: 842  RPETLRSSSRNEHGIKSD-SSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS 900
                L  SSR    + SD + +TD+   +  +   DS    S  E++S         G+ 
Sbjct: 1614 PKPQLSHSSR----LSSDLTRETDEAAFEPDYNESDSESNVSVKEEES--------SGNI 1661

Query: 901  NKSRSDKLGFKSPTSKDD--------KRTEGNKS-KVDTNKAHPDNKAEFPSYLLGGRSG 951
            +K   DK+  K+  S D          R + + S  V  +++H  + ++  S+     S 
Sbjct: 1662 SKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSA 1721

Query: 952  ALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLD 1011
              ++    K K++K        KK +   + K   +  G   +L K  K     +K   +
Sbjct: 1722 ESQDSKKKKKKKEK--------KKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKN 1773

Query: 1012 DVQKLIKDREDKSRSSL 1028
              ++  K+++D+   S+
Sbjct: 1774 KDKEKEKEKDDQKVKSV 1790



 Score = 33.9 bits (76), Expect = 2.3
 Identities = 27/105 (25%), Positives = 43/105 (40%), Gaps = 8/105 (7%)

Query: 124 SQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQT--SSGNRFMPQQNSPVPSPYAPQ 181
           S Y+      H S  S   Q  ++  +P    VPP          +P      P  ++PQ
Sbjct: 527 SCYRSINRGRHHSERSQRTQGPSLPATPVFVPVPPPPLYPPPPHTLPLPPGVPPPQFSPQ 586

Query: 182 SPAGYMPYSHPSSYTTHPQ---MQQASVSSPIVAGGLRNIHDNKV 223
            P G  P   P+ Y+  P       A++S+P V+ G++  H N +
Sbjct: 587 FPPGQPP---PAGYSVPPPGFPPAPANLSTPWVSSGVQTAHSNTI 628


>gi|87299628 biorientation of chromosomes in cell division 1-like
            [Homo sapiens]
          Length = 3051

 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 165/853 (19%), Positives = 317/853 (37%), Gaps = 134/853 (15%)

Query: 437  LQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESA----------- 485
            L Q  S A    +TS  +  ++ S++ P   +   D   + ER   + A           
Sbjct: 211  LNQEASAARASTETSNAKTSERASKKLP--SQPTTDTSTDKERTSEDMADKEKSTADSGG 268

Query: 486  --IERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSI 543
              +E    S+E  D   P+++ K  +Y +E       N+   QE+    N S        
Sbjct: 269  EGLETAPKSEEFSDLPCPVEEIK--NYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKP 326

Query: 544  DLHQAG--RVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPK 601
            D ++ G  + + +    +  D  KK E+ ++  D   +  +E  V SLK   E +    K
Sbjct: 327  DSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQA--KEKEVESLKLPSEKNSNKAK 384

Query: 602  K----KSDPELSKSEM--------------------KQSESRLAESKPNENRLVETKSSE 637
                 K D  L  S++                    + +E  +  S   E   + +   E
Sbjct: 385  TVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEE 444

Query: 638  NKLETKVETQTEELKQNESRTTEC---------------KQNESTIVEPKQN-----ENR 677
               + K +TQT +  + ++++                    +E T+ + +Q+     E R
Sbjct: 445  KNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEER 504

Query: 678  LSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPK 737
            L   + N  K    R +  + + ++ K KG+ R     ++S      PK       E  K
Sbjct: 505  LLRRQINREKLEEKRKQKAE-KTKSSKTKGQGRSSVDLEESSTKSLEPKAARI--KEVLK 561

Query: 738  QKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTK-SDSPRLKSE 796
            ++     +    K   +       +  ++   +  +++  + S+H +  K S S  LK  
Sbjct: 562  ERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHV 621

Query: 797  RAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRG------------DQSRVRR-- 842
             A++   +P  R +SESL    +NK +S    E +R               D   V+R  
Sbjct: 622  HAKSEPSKP-ARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQV 680

Query: 843  ---------PETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSP 893
                     P+  +S+ +NE  +K D S+T  L+   + E   S+E+P   E++  P   
Sbjct: 681  ERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKP---EREKTPSED 737

Query: 894  RV------------KQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEF 941
            ++            K GD  +  S + G K   +   +  +   S  D  +    ++ E 
Sbjct: 738  KLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNER 797

Query: 942  PSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKME-------MKGEPKDKVEKIGLVED 994
               +LG     +  ++I       D NV +E  K E        K E K +      ++ 
Sbjct: 798  KLSVLGKDGKPVSEYII-----KTDENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQK 852

Query: 995  LNKGAKP-VVVLQKLSLDDVQKLIKDREDKSRSSLKP--IKNKPSKSNKGSIDQSVLKEL 1051
             + G+K   + LQ+ S    +           S+LKP  + +K  +  K  +++ ++  L
Sbjct: 853  DSLGSKQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLV--L 910

Query: 1052 PPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDD 1111
              +   + +    +   ++    K++T    PK  +  + E+NDS++    S+   K  +
Sbjct: 911  KSKSKTQGKQVKVVETELQEGATKQATT---PKPDKEKNTEENDSEKQ-RKSKVEDKPFE 966

Query: 1112 DKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDS-----DMEDYSPPPSLS 1166
            +   E       SS    +   SH  +      +Y++   S S      + D     SL 
Sbjct: 967  ETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLK 1026

Query: 1167 EVARKMKKKEKQK 1179
              ++ +KKK++ K
Sbjct: 1027 HSSKDIKKKDENK 1039



 Score = 78.6 bits (192), Expect = 8e-14
 Identities = 198/989 (20%), Positives = 366/989 (37%), Gaps = 166/989 (16%)

Query: 320  ERKQKKQKKMKLGK---------DEKEQSEKAAMYDIISSPSKDSTKLTLRLSRVRSSDM 370
            E+K+K +KK    K         DEK+  EK      + S    +   T+  ++   S +
Sbjct: 337  EKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLI 396

Query: 371  DQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLP 430
            D   D ++ +  S+V  +D+     +   T +  +T   +       +  S  E+     
Sbjct: 397  DSDVDGLTDITVSSVHTSDLS---SFEEDTEEEVVTSDSMEE----GEITSDDEEK---- 445

Query: 431  ANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERER 490
             N+    +  TS +++    SV   +     +  +Y +   D+  E+   +R  +I +E+
Sbjct: 446  -NKQNKTKTQTSDSSEGKTKSV---RHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEK 501

Query: 491  FSKEVQ---DKDKPLKKRKQDSYPQEAGGATG-GNRPASQETGSTGNGSRPALMVSIDLH 546
              + ++   +++K  +KRKQ +   ++    G G      E  ST +    A  +   L 
Sbjct: 502  EERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLK 561

Query: 547  QAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDP 606
            +   ++ + ++++     KK     + N       +ED   +LK++   H E  K  S  
Sbjct: 562  ERKVLEKKVALSKKR---KKDSRNVEENSKKKQQYEEDSKETLKTS--EHCEKEKISSSK 616

Query: 607  ELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNES 666
            EL     K   S+ A        +V+   +E+KLE          ++++ RT+       
Sbjct: 617  ELKHVHAKSEPSKPARRLSESLHVVDENKNESKLE----------REHKRRTST-----P 661

Query: 667  TIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPK 726
             I+E  Q E     T   D K+   RSE     P+  KQK   + E   +K D   ETP 
Sbjct: 662  VIMEGVQEE-----TDTRDVKRQVERSEICTEEPQ--KQKSTLKNEKHLKKDDS--ETPH 712

Query: 727  QKGDGRPETPKQKGESRPETPKQKNEGRPETPKHR------HDNRRDSGKPSTEK----K 776
             K   + E    K   +PE  K  +E +    KH+      H    ++   S+EK    +
Sbjct: 713  LKSLLKKEVKSSK--EKPEREKTPSEDKLSV-KHKYKGDCMHKTGDETELHSSEKGLKVE 769

Query: 777  PEVSKHKQDTKSDSPRLKSERAEALKQRP------DGRSVSESLRRDHDNKQKSDDR--- 827
              + K  Q TK  S      +++   +R       DG+ VSE + +  +N +K +++   
Sbjct: 770  ENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKER 829

Query: 828  --------GESERHRGDQSRVRRPE--------TL--RSSSRNEHGIKSDSS------KT 863
                     E +  R   S++++          TL  RS S +E     DS+      K 
Sbjct: 830  RLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDSTNMDSNLKP 889

Query: 864  DKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEG 923
            +++  K +  +    E     + KS+    +VK  ++           +P    +K TE 
Sbjct: 890  EEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEE 949

Query: 924  NKSKVDTNKAHPDNKAE----------FPSYLLGGRSGALKNFVIP----KIKRDKDGNV 969
            N S+        D   E            S     +  +     +P    K K DKD   
Sbjct: 950  NDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTS 1009

Query: 970  TQETKKME-------MKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDRED 1022
            T+  +K+        +K   KD  +K     D NK           S D   K +    +
Sbjct: 1010 TRLERKLSDGHKSRSLKHSSKDIKKK-----DENK-----------SDDKDGKEVDSSHE 1053

Query: 1023 KSRSSLKPIKNKPSK----SNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRST 1078
            K+R +   ++ K S+    + +GS+ Q + K    E LA    + P    ++  K+    
Sbjct: 1054 KARGNSSLMEKKLSRRLCENRRGSLSQEMAKG--EEKLAANTLSTPSGSSLQRPKKSGDM 1111

Query: 1079 ----------VNEKP---KYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSS 1125
                      ++ +P      E+S  +DN ++ + +     + K    A   ++  R  +
Sbjct: 1112 TLIPEQEPMEIDSEPGVENVFEVSKTQDNRNNNSQQDIDSENMKQKTSATVQKDELRTCT 1171

Query: 1126 GDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYE 1185
             D + +  +++  R  G G   N           +    +     KM   EK+   +   
Sbjct: 1172 ADSKATAPAYKPGR--GTGVNSNSEKHADHRSTLTKKMHIQSAVSKMNPGEKEPIHRG-- 1227

Query: 1186 PKLTPEEMMDSSTFKRFTASIENILDNLE 1214
               T E  +DS T  R   S  +  D ++
Sbjct: 1228 ---TTEVNIDSETVHRMLLSAPSENDRVQ 1253



 Score = 58.2 bits (139), Expect = 1e-07
 Identities = 94/508 (18%), Positives = 197/508 (38%), Gaps = 81/508 (15%)

Query: 734  ETPKQKGESRPETPKQKNEGRP-ETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPR 792
            E   +K  S+P T    ++ R  E    +  +  DSG    E  P     K +  SD P 
Sbjct: 231  ERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAP-----KSEEFSDLPC 285

Query: 793  LKSERAEALKQRPDGRSVSESLRRDH-DNKQKSDDRGESERHRGDQSRVRRPETLRSSSR 851
               E     K+  +   +++ ++++  + K KS D+GE +    ++   ++ +  ++  +
Sbjct: 286  PVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKK 345

Query: 852  NEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQG------------- 898
             +H  KS+ ++  K E++ + +  +S + PS             K+              
Sbjct: 346  FDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTD 405

Query: 899  --DSNKSRSDKLGFKSPTSKD----DKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGA 952
               S+   SD   F+  T ++    D   EG  +  D  K   +      S    G++ +
Sbjct: 406  ITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKS 465

Query: 953  L------KNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQ 1006
            +      K ++  K   D D  +T E ++  +  E +++                 ++ +
Sbjct: 466  VRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEER-----------------LLRR 508

Query: 1007 KLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLC 1066
            +++ + +++  K + +K++SS    K K    +   +++S  K L P+            
Sbjct: 509  QINREKLEEKRKQKAEKTKSS----KTKGQGRSSVDLEESSTKSLEPK-----------A 553

Query: 1067 ERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDD-----KAWEYEERD 1121
             R+K   ++R  + +K     +S     DS    E+S+K+ + ++D     K  E+ E++
Sbjct: 554  ARIKEVLKERKVLEKK---VALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKE 610

Query: 1122 RRSSGD-----HRRSGHSHEGRRSSGG----GRYRNRSPSDSDMEDYSPPPSLSEVARKM 1172
            + SS       H +S  S   RR S         +N S  + + +  +  P + E  ++ 
Sbjct: 611  KISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEE 670

Query: 1173 KKKEKQKKRKAYEPKLTPEEMMDSSTFK 1200
                  K++       T E     ST K
Sbjct: 671  TDTRDVKRQVERSEICTEEPQKQKSTLK 698



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 71/285 (24%), Positives = 118/285 (41%), Gaps = 45/285 (15%)

Query: 644  VETQTEELKQNESRTTECKQNE---STIVEPKQNENRLS-----------DTKPNDNKQN 689
            VE   +E+++ E    + K+ +   S+  EP  N + L            +T+P+D K+ 
Sbjct: 2754 VEADPKEVEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEE 2813

Query: 690  NGRS-----ETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRP 744
            N R      +T+     T  +  E + E    ++ G  E P+Q  D   +T K + E +P
Sbjct: 2814 NSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTG--EKPEQNDD---DTIKSQEEDQP 2868

Query: 745  ETPKQKNEGRPE------TPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERA 798
               K+K  GRP       T K + D++ D+G  + E+ P  SK K     +S +  +   
Sbjct: 2869 IIIKRK-RGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQ 2927

Query: 799  EALKQRPDG--RSVSESLRRDHDNKQK---SDDRGESERHRGDQSRVRRPETLRSSSRNE 853
            E      DG  + V+   RR    K+    SDD   SE  R  Q  V  P         E
Sbjct: 2928 ERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPV--------E 2979

Query: 854  HGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPD-SPRVKQ 897
               + +S + ++ E +       +R    S  Q+S+   SP +K+
Sbjct: 2980 DKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKR 3024



 Score = 48.5 bits (114), Expect = 9e-05
 Identities = 85/407 (20%), Positives = 159/407 (39%), Gaps = 41/407 (10%)

Query: 548  AGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPE 607
            +G+   QAS  +  D     +   +  D  V+V  E+ V  +      + E+P       
Sbjct: 2610 SGKWTDQASAEKTGDDNSTRKSFPEEGDIMVTVSSEENVCDI-----GNEESPLNVLGGL 2664

Query: 608  LSKSEMKQSESRLAESKPNENRLVETKS-SENKLETKVETQTEELKQNESRTTECK--QN 664
              K+ +K      +E + N   L   +S    K     E Q E L  NES   E    + 
Sbjct: 2665 KLKANLKMEAYVPSEEEKNGEILAPPESLCGGKPSGIAELQREPLLVNESLNVENSGFRT 2724

Query: 665  ESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPET 724
               I     N+  +S       +++N  + +  S    PK+  E     PK+K   H  +
Sbjct: 2725 NEEIHSESYNKGEISS-----GRKDNAEAISGHSVEADPKEVEEEERHMPKRKRKQHYLS 2779

Query: 725  PKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQ 784
             + + D  P+      +SR ET +++    PET  H      D+ + ++    E+ K   
Sbjct: 2780 SEDEPDDNPDVL----DSRIETAQRQ---CPETEPH------DTKEENSRDLEELPKTSS 2826

Query: 785  DTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGES---ERHRGDQSRVR 841
            +T S + R+  E+ E       G    E   ++ D+  KS +  +    +R RG   +  
Sbjct: 2827 ETNSTTSRVMEEKDEYSSSETTG----EKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYP 2882

Query: 842  RPETL--RSSSRNEHGI----KSDSSKTDKLER--KHRHESGDSRERPSSGEQKSRPDSP 893
               TL  +  S+ + GI    +S SS   K+ +  +   E+ + +ER  S +        
Sbjct: 2883 VETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVT 2942

Query: 894  RVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAE 940
             V++      RS  +   + +S+ +++ + + S    +K   ++  E
Sbjct: 2943 SVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEE 2989



 Score = 45.8 bits (107), Expect = 6e-04
 Identities = 168/792 (21%), Positives = 272/792 (34%), Gaps = 133/792 (16%)

Query: 317  DSPERKQKKQKKMKL---GKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRV-------- 365
            D  ERK K + + KL   GKD K  SE     D   +  K++ K   RLS          
Sbjct: 785  DKTERKSKHRNERKLSVLGKDGKPVSEYIIKTD--ENVRKENNKKERRLSAEKTKAEHKS 842

Query: 366  -RSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQE 424
             RSSD   Q+D +   ++    +     +  Y         T  D N  L   + + +++
Sbjct: 843  RRSSDSKIQKDSLGSKQHGITLQRR---SESYSEDKCDMDSTNMDSN--LKPEEVVHKEK 897

Query: 425  QTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERES 484
            +       +  VL+  +    KQ +    + Q+  ++Q             + E+   E+
Sbjct: 898  RRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATT-------PKPDKEKNTEEN 950

Query: 485  AIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSID 544
              E++R SK V+DK            P E  G       AS    ST   S         
Sbjct: 951  DSEKQRKSK-VEDK------------PFEETGVEPVLETASSSAHSTQKDSS-------- 989

Query: 545  LHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKS 604
             H+A    ++     D DS     E ++ +D   S        SLK + ++  +  + KS
Sbjct: 990  -HRAKLPLAKEKYKSDKDSTSTRLE-RKLSDGHKS-------RSLKHSSKDIKKKDENKS 1040

Query: 605  DPELSKS-----EMKQSESRLAESKPN----ENRLVETKSSENKLETKVETQTEELKQNE 655
            D +  K      E  +  S L E K +    ENR         K E K+   T       
Sbjct: 1041 DDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAANTLSTPSGS 1100

Query: 656  SRTTECKQNESTIVEPKQN----------ENRLSDTKPNDNKQNNGR----SETTKSRPE 701
            S     K  + T++ P+Q           EN    +K  DN+ NN +    SE  K +  
Sbjct: 1101 SLQRPKKSGDMTLI-PEQEPMEIDSEPGVENVFEVSKTQDNRNNNSQQDIDSENMKQKTS 1159

Query: 702  TPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHR 761
               QK E R  T   K+              P     +G       ++  + R    K  
Sbjct: 1160 ATVQKDELRTCTADSKATA------------PAYKPGRGTGVNSNSEKHADHRSTLTKKM 1207

Query: 762  HDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNK 821
            H     S     EK+P + +   +   DS  +                +  S   ++D  
Sbjct: 1208 HIQSAVSKMNPGEKEP-IHRGTTEVNIDSETV--------------HRMLLSAPSENDRV 1252

Query: 822  QKSDDRGESERH--RGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRE 879
            QK+     +E H  +GD        TL  S+  +      S     L   +  +     +
Sbjct: 1253 QKNLKNTAAEEHVAQGD-------ATLEHSTNLDSSPSLSSVTVVPLRESYDPDVIPLFD 1305

Query: 880  RPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDT-NKAHPDNK 938
            + +  E  +   SP       N+S + +      TS  D +  G    VDT  KA   +K
Sbjct: 1306 KRTVLEGSTASTSPADHSALPNQSLTVRESEVLKTS--DSKEGGEGFTVDTPAKASITSK 1363

Query: 939  AEFP----SYLLGGRSG--------ALKNFVIPKIKRDKDGNVTQETKK-MEMKGEPKDK 985
               P    + LL G+ G         L   ++      K+G +    KK  ++  EP  K
Sbjct: 1364 RHIPEAHQATLLDGKQGKVIMPLGSKLTGVIVENENITKEGGLVDMAKKENDLNAEPNLK 1423

Query: 986  VEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGS-ID 1044
                  VE+  K    V  +  L+ +   + +K +  +S   +K I     + N+ S +D
Sbjct: 1424 QTIKATVENGKKDGIAVDHVVGLNTEKYAETVKLKHKRSPGKVKDISIDVERRNENSEVD 1483

Query: 1045 QSVLKELPPELL 1056
             S      P +L
Sbjct: 1484 TSAGSGSAPSVL 1495



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 51/241 (21%), Positives = 88/241 (36%), Gaps = 25/241 (10%)

Query: 527  ETGSTGNGSRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIV 586
            +T S  N +   +M   D + +     +     D D+IK  EE     D P+      I+
Sbjct: 2823 KTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEE-----DQPI------II 2871

Query: 587  GSLKSTPENHP-ETPKK-----KSDPELSKSEMKQSESRLA-----ESKPNENRLVETKS 635
               +  P  +P ET  K     K+D  +   E   S S+L      ES      L E   
Sbjct: 2872 KRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSI 2931

Query: 636  SENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNG--RS 693
            S +  E K+ T      +   R+     +  +    ++ +  +SD   +  +Q +     
Sbjct: 2932 SNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEE 2991

Query: 694  ETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEG 753
            E  +  P     +  +R E  + K+   P   K+K +  P   + +G+ R E    K   
Sbjct: 2992 EEEEDEPSGATTRSTTRSEAQRSKTQLSPSI-KRKREVSPPGARTRGQQRVEEAPVKKAK 3050

Query: 754  R 754
            R
Sbjct: 3051 R 3051



 Score = 37.7 bits (86), Expect = 0.16
 Identities = 64/378 (16%), Positives = 142/378 (37%), Gaps = 42/378 (11%)

Query: 810  VSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERK 869
            V+ESL  ++   + +++      ++G+ S  R+      S    H +++D  +   +E +
Sbjct: 2711 VNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAISG---HSVEADPKE---VEEE 2764

Query: 870  HRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVD 929
             RH     R++     +    D+P V       SR +    + P ++     E N   ++
Sbjct: 2765 ERHMPKRKRKQHYLSSEDEPDDNPDVLD-----SRIETAQRQCPETEPHDTKEENSRDLE 2819

Query: 930  TNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKI 989
                      E P      ++ +  N    ++  +KD   + ET   + +    D ++  
Sbjct: 2820 ----------ELP------KTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKS- 2862

Query: 990  GLVEDLNKGAKPVVVLQKLSLD---DVQKLIKDRED-KSRSSLKPIKNKPSKSNKGSIDQ 1045
                   +  +P+++ +K        V+  +K ++D K+ + +  ++  PS S    +  
Sbjct: 2863 ------QEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQT 2916

Query: 1046 SVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYA-EISSDEDNDSDEAFESSR 1104
                +    L     S     E++  + R+R     KPK +  +S D ++   E      
Sbjct: 2917 DESNKETANLQERSISNDDGEEKIVTSVRRRG---RKPKRSLTVSDDAESSEPERKRQKS 2973

Query: 1105 KRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPS 1164
                 +D K  E +E +     D      +    RS         SPS     + SPP +
Sbjct: 2974 VSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKREVSPPGA 3033

Query: 1165 LSEVARKMKKKEKQKKRK 1182
             +   +++++   +K ++
Sbjct: 3034 RTRGQQRVEEAPVKKAKR 3051



 Score = 32.3 bits (72), Expect = 6.8
 Identities = 46/214 (21%), Positives = 83/214 (38%), Gaps = 27/214 (12%)

Query: 2439 PYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSD----SE 2494
            P+ T+EE    +  +  T S + S   +  +E   KD+    +++  K  ++ D    S+
Sbjct: 2807 PHDTKEENSRDLEELPKTSSETNSTTSRVMEE---KDEYSSSETTGEKPEQNDDDTIKSQ 2863

Query: 2495 EE-----VSRPRKSRKRVDSDSDSDSEDDINSVMKCLPENSAPLIEFANVSQGILLLLML 2549
            EE     + R R   ++   ++    +DD  +    +    +P       S   L ++  
Sbjct: 2864 EEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSP-------SSSKLKVMQT 2916

Query: 2550 KQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEE 2609
             +  K      +  I      E      +   RK      PK++L    SD A S   E 
Sbjct: 2917 DESNKETANLQERSISNDDGEEKIVTSVRRRGRK------PKRSLTV--SDDAESSEPER 2968

Query: 2610 VKRSIVKQYLDFKLLMEHLDPDEEEEEGEVSAST 2643
             ++  V   ++ K   E  + +EEEEE E S +T
Sbjct: 2969 KRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGAT 3002


>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
          Length = 754

 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 121/583 (20%), Positives = 212/583 (36%), Gaps = 61/583 (10%)

Query: 553  SQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSE 612
            S +S + DSDS    +     +D+  +  ++      K    +     +KK   +  KS 
Sbjct: 196  SSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSA 255

Query: 613  MKQSESRLAESKPN------------ENRLVETKSSENKLETKVETQTEELKQNESRTTE 660
              +SE+   E++P             ENR +  KS           + E   +   R  E
Sbjct: 256  SSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPK------ADEKERKNRERERERE 309

Query: 661  CKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG 720
            C    S   +P   + RL  T+     +  G       R  TP  +  SR    + ++  
Sbjct: 310  CNPPNS---QPASYQRRLLVTRSGRKIKGRG-----PRRYRTP-SRSRSRDRFRRSETPP 360

Query: 721  HPETPKQKGDGRPETPKQ---KGESRPETPKQKNEGRPETPKHR----HDNRRDSGKPST 773
            H     Q+      +  +   KG+       ++N+  P   K R    H N  +S     
Sbjct: 361  HWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKN 420

Query: 774  EKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERH 833
            EK+ +V  HK ++K    R  SE+ +  K +   R+ S+S R     K KS +R +S+ +
Sbjct: 421  EKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKS-RSKSKEKSKSKER-DSKHN 478

Query: 834  RGDQSRVRRPETLRSSSRNEHGIK----------SDSSKTDKLERKHRHESGDSRERPSS 883
            R ++ R+R     RS  R+   +K           D  ++   E+  + ES  +    S 
Sbjct: 479  RNEEKRMRS----RSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSK 534

Query: 884  GEQKSRPDSPRVKQGDSNK---SRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAE 940
             ++K R    R ++ D  K   S + +   +S +    +R        D +++   ++  
Sbjct: 535  SKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYR 594

Query: 941  FPSYLLGGRSGALKNFVIPKIKRDKD----GNVTQETKKMEMKGEPKDKVEKIGLVEDLN 996
               Y   GRS + +    P   R KD       ++ +++ E +   KDK           
Sbjct: 595  EQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHR 654

Query: 997  KGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELL 1056
            K              D       RE K+     P       S    +  S+LK    E  
Sbjct: 655  KENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDE-- 712

Query: 1057 AEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEA 1099
             +I S++   E  K   ++   V+EK K  +  S    D D++
Sbjct: 713  -KIRSSVEK-ENQKSKGQENDHVHEKNKKFDHESSPGTDEDKS 753



 Score = 66.6 bits (161), Expect = 3e-10
 Identities = 113/547 (20%), Positives = 199/547 (36%), Gaps = 49/547 (8%)

Query: 740  GESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAE 799
            GE  P++  +K E      K RH +   S   S++             SDS     E+++
Sbjct: 175  GELIPKSKVKKEE------KKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSK 228

Query: 800  ALKQ--RPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIK 857
              K+  R + R   +  ++   +K+ +    E+E          RPE +     N   ++
Sbjct: 229  KRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMR 288

Query: 858  SDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRV-KQGDSNKSRSDKLGFKSPTSK 916
                K D+ ERK+R    +    P + +  S      V + G   K R  +  +++P S+
Sbjct: 289  KSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPR-RYRTP-SR 346

Query: 917  DDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKM 976
               R    +S+   +      +A+      G R        + +IK ++   V  + +K+
Sbjct: 347  SRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKI 406

Query: 977  ----EMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIK 1032
                 +   P  K EK   V+D    +K   + +    DD  K    +  KS+S  K  +
Sbjct: 407  TDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKE 466

Query: 1033 NKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRK---RSTVNEKPKYAEIS 1089
               SK      +++  K +           +   E+   +K K   RS   EK K  E  
Sbjct: 467  KSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESK 526

Query: 1090 SDEDNDSDEAFESSRKRHKKDDD-------KAWEYEERDRRSSGDH----RRSGHSHEGR 1138
            S+E +D  ++ E  R+   +  +        ++    R+R  S D     R   H  +  
Sbjct: 527  SNE-HDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRS 585

Query: 1139 RSSGGGRYRN---RSPSDSDMEDYSPPPSLSEV---------ARKMKKKEKQKKRK---- 1182
            RS    RYR    R    S   +   PP  S           +R  +++E Q + K    
Sbjct: 586  RSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYR 645

Query: 1183 AYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELG 1242
              E K +  +    S  + ++ S ++   N  +       D D+ P   +    Q NEL 
Sbjct: 646  NQESKSSHRKENSESEKRMYSKSRDH---NSSNNSREKKADRDQSPFSKIKQSSQDNELK 702

Query: 1243 SESAKIK 1249
            S   K K
Sbjct: 703  SSMLKNK 709



 Score = 64.3 bits (155), Expect = 2e-09
 Identities = 94/538 (17%), Positives = 195/538 (36%), Gaps = 32/538 (5%)

Query: 472 DALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGST 531
           D+ +  +  + ESA E +   ++ + +    K +K+    +++  +      A       
Sbjct: 209 DSQSSSDSSDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQP 268

Query: 532 GNGSRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCN---DAPVSVLQEDIVGS 588
            +  RP  +  I  ++     S     +     ++ E  ++CN     P S  +  +V  
Sbjct: 269 QSTVRPEEIPPIPENRFLMRKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLV-- 326

Query: 589 LKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETK-----SSENKLETK 643
            +S  +     P++   P  S+S   +   R +E+ P+  + ++       SS  +    
Sbjct: 327 TRSGRKIKGRGPRRYRTPSRSRS---RDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKG 383

Query: 644 VETQTEELKQNESRTTECKQNESTI---VEPKQNENRLSDTKPNDNKQNNGRSETTKSRP 700
            +++  E+K+N+      K+ + T    V    N     + K  D+K N+   +  ++  
Sbjct: 384 DKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSE 443

Query: 701 ETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKH 760
           +  K K + +     +      E  K K         ++   R  +  + +E   E  K 
Sbjct: 444 KDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQ 503

Query: 761 RHDNRRDSGKP-STEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPD---GRSVSESLRR 816
                +D  +  S EK  ++     +      + K  RA++  +  D   G+    S  R
Sbjct: 504 SDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTR 563

Query: 817 DHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGI------KSDSSKTDKLERKH 870
           +    +    R  S  H  D+SR +     R       G       ++   ++   +R+ 
Sbjct: 564 ERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRR 623

Query: 871 RHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDT 930
           R     S ER  S  Q    D  R ++  S+  + +    K   SK       N S+   
Sbjct: 624 RRRDSRSSEREES--QSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSR--- 678

Query: 931 NKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEK 988
            K    +++ F       +   LK+ ++ K K D+    + E +  + KG+  D V +
Sbjct: 679 EKKADRDQSPFSKIKQSSQDNELKSSML-KNKEDEKIRSSVEKENQKSKGQENDHVHE 735



 Score = 62.4 bits (150), Expect = 6e-09
 Identities = 120/614 (19%), Positives = 222/614 (36%), Gaps = 97/614 (15%)

Query: 639  KLETKVETQTEELKQNESRTTECKQN-ESTIVEPKQNENRLSDTKPNDNKQNNGRSETTK 697
            +L  K + + EE K+++S ++    + +S      Q+ +  SD++    +++  R +  +
Sbjct: 176  ELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHR 235

Query: 698  SRPETPKQKGESRPETPKQ---KSDGHPETPKQKGDGRPE----TPKQKGESRPETPK-- 748
                  K++ + R ++ K    +S+      + +   RPE     P+ +   R   PK  
Sbjct: 236  KNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKAD 295

Query: 749  QKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGR 808
            +K     E  + R  N  +S   S +++  V++  +  K   PR               R
Sbjct: 296  EKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRY-------------R 342

Query: 809  SVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLER 868
            + S S  RD   + ++      E  R  + RV         S  E  IK D S+ ++++ 
Sbjct: 343  TPSRSRSRDRFRRSETPPHWRQEMQRAQRMRV---------SSGERWIKGDKSELNEIKE 393

Query: 869  KHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKV 928
              R         P   +++   D   V +  + K+  +K      ++  ++    N  K 
Sbjct: 394  NQR--------SPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKD 445

Query: 929  DTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETK-KMEMKGEPKDKVE 987
            D  K     +A+  S          K       +RD   N  +E + +   KG   + V+
Sbjct: 446  DKYKNKVKKRAKSKSRSKSKEKSKSK-------ERDSKHNRNEEKRMRSRSKGRDHENVK 498

Query: 988  KIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSV 1047
            +     D +KG                   KD+E +SRS  K  K   SKSN+    +S 
Sbjct: 499  EKEKQSD-SKG-------------------KDQE-RSRSKEKS-KQLESKSNEHDHSKSK 536

Query: 1048 LKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRH 1107
             K+                 R +   R+      K  Y   + +     D +     + H
Sbjct: 537  EKD----------------RRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTH 580

Query: 1108 KKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSE 1167
             +D  ++ EY    R    ++RR G S    R +  GR R++       +  S     S+
Sbjct: 581  DRDRSRSKEYH---RYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQ 637

Query: 1168 VARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAF------ 1221
               K K + ++ K    +     E+ M S +  R   S  N  +   D D + F      
Sbjct: 638  SRNKDKYRNQESKSSHRKENSESEKRMYSKS--RDHNSSNNSREKKADRDQSPFSKIKQS 695

Query: 1222 GDDDEIPQELLLGK 1235
              D+E+   +L  K
Sbjct: 696  SQDNELKSSMLKNK 709



 Score = 32.7 bits (73), Expect = 5.2
 Identities = 40/175 (22%), Positives = 63/175 (36%), Gaps = 54/175 (30%)

Query: 2381 GFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLNLFDDTAKTDVTMLLYIADNLACFPY 2440
            GF +DES +              +H + FL+S+ N   DT             N + F  
Sbjct: 93   GFFEDESFAV-------------KHNKEFLLSMANRGKDT-------------NGSQFFI 126

Query: 2441 QTQEEPLFIMHHIDITLSVSGSNLLQSF-------------------------KESMVKD 2475
             T+  P    HH+     +SG  +++                           K  + K+
Sbjct: 127  TTKPTPHLDGHHVVFGQVISGQEVVREIENQKTDAASKPFAEVRILSCGELIPKSKVKKE 186

Query: 2476 KRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINSVMKCLPENS 2530
            ++K  KSS S  + SSDS+        S     SDS+S +E+      K   +NS
Sbjct: 187  EKKRHKSSSSSSSSSSDSDSSSDSQSSSDS---SDSESATEEKSKKRKKKHRKNS 238


>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
          Length = 1007

 Score = 80.5 bits (197), Expect = 2e-14
 Identities = 129/596 (21%), Positives = 234/596 (39%), Gaps = 66/596 (11%)

Query: 470  ELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETG 529
            +LD LA +E +E++ A+ +     E+      ++ + Q        G   G+    +   
Sbjct: 99   KLDDLALLEDLEKQRALIKAELDNEL------MEGKVQSGMGLILQGYESGSEEEGEIHE 152

Query: 530  STGNGSRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSL 589
               NG+R +   S    +   VD++ +  + S S  K E  +  +D   S    +IV   
Sbjct: 153  KARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSK-ERTRHRSDKKKSKGGIEIVKE- 210

Query: 590  KSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTE 649
            K+T     E  K KS  + SKS   Q ++R ++S     R      S+ K+  K  + T+
Sbjct: 211  KTTRSKSKERKKSKSPSKRSKS---QDQARKSKSPTLRRR------SQEKIG-KARSPTD 260

Query: 650  ELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGES 709
            +  + E ++    + +S I+   ++ +R    K        G+S+  +SR +  K K   
Sbjct: 261  DKVKIEDKSKSKDRKKSPIINESRSRDR--GKKSRSPVDLRGKSKDRRSRSKERKSK--- 315

Query: 710  RPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSG 769
            R ET K+K          K   +  +  ++  S    P +  + R  +PK R  +RR   
Sbjct: 316  RSETDKEKKP-------IKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKSRRSRS 368

Query: 770  KPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDN----KQKSD 825
                +++ + SK    T S   R KS   E  ++ P+ R +S    R  D+    +++S 
Sbjct: 369  PLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILSRRERSK 428

Query: 826  DRGESERHRGDQSRVRRPETLRSSS--RNEHGIKSDSSKTDKLERKHRHESGDSRERPSS 883
            D     R    + R R P   RS S  R     +  S    + +R  R  S   R   S 
Sbjct: 429  DASPINRWSPTRRRSRSPIRRRSRSPLRRSRSPRRRSRSPRRRDRGRRSRSRLRRRSRSR 488

Query: 884  GEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPS 943
            G ++ R  S +VK+     S S+ +  +  +S DD   + +  + D        + +   
Sbjct: 489  GGRRRRSRS-KVKEDKFKGSLSEGMKVEQESSSDDNLEDFDVEEEDEEALIEQRRIQ--- 544

Query: 944  YLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVV 1003
                      +  ++ K K         E   M +  EP              +   P  
Sbjct: 545  ----------RQAIVQKYK------YLAEDSNMSVPSEPSSPQS-----STRTRSPSPDD 583

Query: 1004 VLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPS-KSNKGSIDQSVLKELPPELLAE 1058
            +L++++  DV++  ++  D   +S+K   N  + + N GS   S  K L P++  E
Sbjct: 584  ILERVAA-DVKEYERENVDTFEASVKAKHNLMTVEQNNGS---SQKKLLAPDMFTE 635



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 128/616 (20%), Positives = 218/616 (35%), Gaps = 131/616 (21%)

Query: 641  ETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRP 700
            ET+   +  E++   S  +  ++N     +  QN++     K + ++  + + + +    
Sbjct: 5    ETQSLREQPEMEDANSEKSINEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHSSEED 64

Query: 701  ETPKQKGESRPETPKQK-------SDGHPETPKQKGDG---RPETPKQKGESRPETPKQK 750
            +  K K + + +  K+K        +G     + K D      +  KQ+   + E   + 
Sbjct: 65   KDKKHKHKHKHKKHKRKEIIDASDKEGMSPAKRTKLDDLALLEDLEKQRALIKAELDNEL 124

Query: 751  NEGRPET--------------------PKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDS 790
             EG+ ++                     K R+ NR  +   ST+ K E+  +K  TK   
Sbjct: 125  MEGKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKK-- 182

Query: 791  PRLKSERAEALKQRPDGRS-------VSESLRRDHDNKQKSDDRGESERHRGDQSRVRRP 843
             R KS   E  + R D +        V E   R    ++K            DQ+R  + 
Sbjct: 183  -RSKSRSKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKS 241

Query: 844  ETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKS 903
             TLR  S+ + G K+ S   DK++ + + +S D ++ P   E +SR       +G  ++S
Sbjct: 242  PTLRRRSQEKIG-KARSPTDDKVKIEDKSKSKDRKKSPIINESRSR------DRGKKSRS 294

Query: 904  RSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKR 963
              D  G         K  +  +S+ D  K       + PS          K+    K  R
Sbjct: 295  PVDLRGKSKDRRSRSKERKSKRSETDKEK----KPIKSPS----------KDASSGKENR 340

Query: 964  DKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDK 1023
                   +  K+  +  +P+D                                      K
Sbjct: 341  SPSRRPGRSPKRRSLSPKPRD--------------------------------------K 362

Query: 1024 SRSSLKPIKN-KPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEK 1082
            SR S  P+ N + SK +K     S  + L P   A+  S           +RKR     +
Sbjct: 363  SRRSRSPLLNDRRSKQSK-----SPSRTLSPGRRAKSRSL----------ERKR----RE 403

Query: 1083 PKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSG 1142
            P+   +SS      D+    SR+   KD      +    RRS    RR   S    R S 
Sbjct: 404  PERRRLSSPRTRPRDDIL--SRRERSKDASPINRWSPTRRRSRSPIRR--RSRSPLRRSR 459

Query: 1143 GGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRF 1202
              R R+RSP   D        S S + R+ + +  +++R   + K   E+    S  +  
Sbjct: 460  SPRRRSRSPRRRD----RGRRSRSRLRRRSRSRGGRRRRSRSKVK---EDKFKGSLSEGM 512

Query: 1203 TASIENIL-DNLEDMD 1217
                E+   DNLED D
Sbjct: 513  KVEQESSSDDNLEDFD 528



 Score = 57.8 bits (138), Expect = 2e-07
 Identities = 83/418 (19%), Positives = 163/418 (38%), Gaps = 43/418 (10%)

Query: 793  LKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRN 852
            + +   ++L+++P+    +     + +N + S+D+ +++      SR ++ +    S   
Sbjct: 1    MAAAETQSLREQPEMEDANSEKSINEENGEVSEDQSQNKH-----SRHKKKKHKHRSKHK 55

Query: 853  EHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKS 912
            +H   S+  K  K + KH+H+    +E   + +++    + R K  D            +
Sbjct: 56   KHKHSSEEDKDKKHKHKHKHKKHKRKEIIDASDKEGMSPAKRTKLDD-----------LA 104

Query: 913  PTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQE 972
                 +K+    K+++D        ++     L G  SG+ +   I   ++ ++GN    
Sbjct: 105  LLEDLEKQRALIKAELDNELMEGKVQSGMGLILQGYESGSEEEGEIH--EKARNGN-RSS 161

Query: 973  TKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDRED--KSRSSLKP 1030
            T+    KG       K+ LV+  NK     +  +K S    ++  + R D  KS+  ++ 
Sbjct: 162  TRSSSTKG-------KLELVD--NK-----ITTKKRSKSRSKERTRHRSDKKKSKGGIEI 207

Query: 1031 IKNKP--SKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNK--RKRSTVNEKPKYA 1086
            +K K   SKS +    +S  K    +  A  +S  P   R    K  + RS  ++K K  
Sbjct: 208  VKEKTTRSKSKERKKSKSPSKRSKSQDQAR-KSKSPTLRRRSQEKIGKARSPTDDKVKIE 266

Query: 1087 EISSDEDNDSDEAFESSRKRHKKDDDKA---WEYEERDRRSSGDHRRSGHSHEGRRSSGG 1143
            + S  +D         SR R +    ++      + +DRRS    R+S  S   +     
Sbjct: 267  DKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKRSETDKEKKPI 326

Query: 1144 GRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFKR 1201
                  + S  +    S  P  S   R +  K + K R++  P L       S +  R
Sbjct: 327  KSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKSRRSRSPLLNDRRSKQSKSPSR 384


>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
          Length = 1564

 Score = 79.3 bits (194), Expect = 5e-14
 Identities = 164/884 (18%), Positives = 327/884 (36%), Gaps = 109/884 (12%)

Query: 261  SSTMRNAASFPLRSPQPVCSPAGSEG--TPKGSRPPLILQSQSLPCSS----------PR 308
            S ++R ++  P R   P  S A  +   T   S P L  Q  S    S          P 
Sbjct: 209  SPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPP 268

Query: 309  DVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRVRSS 368
             +P DI L    +K K++ K+K   +EK +  K    D      K     +   +    S
Sbjct: 269  PIPEDIALG---KKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHS 325

Query: 369  DMDQQEDMISGVENSNVSEND-IPFNVQYPGQTSKTPITPQDINRPLNA--AQCLSQQEQ 425
             +  +    S    S++  +   P   + P  + +  +TP  + R  +   +  LS  ++
Sbjct: 326  PISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPP-LRRSASPYPSHSLSSPQR 384

Query: 426  TAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESA 485
                P ++ P+ ++               + ++ SQ      E   D   + +R E++S 
Sbjct: 385  KQSPPRHRSPMREKGR------------HDHERTSQSHDRRHERREDTRGKRDR-EKDSR 431

Query: 486  IERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDL 545
             ERE    +   +D      + D  P++     G +R  +++T       R  L  S D+
Sbjct: 432  EEREYEQDQSSSRD-----HRDDREPRD-----GRDRRDARDTRD-----RRELRDSRDM 476

Query: 546  HQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSD 605
              +  +   +  T++S   + P + +   DA                 +       +K D
Sbjct: 477  RDSREMRDYSRDTKES---RDPRDSRSTRDA-------------HDYRDREGRDTHRKED 520

Query: 606  PELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNE 665
                +S          ES   E R      +E++ E++ E + + + ++  R  E  +  
Sbjct: 521  TYPEESRSYGRNHLREESSRTEIR------NESRNESRSEIRNDRMGRSRGRVPELPEKG 574

Query: 666  STIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETP 725
            S      Q ++  S++  +D+ +           PE    + ++R  + +++        
Sbjct: 575  SRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDN-RDQARDSSFERRHGERDRRD 633

Query: 726  KQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQ- 784
             ++ D RP +P +      E   +++E R E    R D+RRD      +++ E  + ++ 
Sbjct: 634  NRERDQRPSSPIRHQGRNDEL--ERDERREERRVDRVDDRRDERARERDRERERDRERER 691

Query: 785  DTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPE 844
            + + +  R + +  E  ++R   R       RD +  +  D   E ER R ++ R +  E
Sbjct: 692  ERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERER-ERDREKERE 750

Query: 845  TLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRP-DSPRVKQGDSNKS 903
              R     E   + +  +  + ER+   E    RER    E K +  D  R K+ +  + 
Sbjct: 751  REREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIRED 810

Query: 904  RSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGG----RSGALKNFVIP 959
            R+ + G     SK   R EG+ S   + K   ++  +  +Y  G     +   L   V P
Sbjct: 811  RNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRP 870

Query: 960  KIKR---------DKDGNVTQETKKMEMKGEPK--DKVEKIGLVEDLNKGAKPVVVLQKL 1008
            +  R         D+ G   +E +K E K   +  ++ E    V  ++K  +   +L+  
Sbjct: 871  QESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESS 930

Query: 1009 SLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCER 1068
             +   Q +I   + + R +     ++  K  K  I +  +K+   + +            
Sbjct: 931  RMR-AQDIIGHHQSEDRETSDRAHDENKK--KAKIQKKPIKKKKEDDVGI---------- 977

Query: 1069 VKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDD 1112
                  +R  +    +  ++ S +     ++ E  RK+ K D D
Sbjct: 978  ------ERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSD 1015



 Score = 72.0 bits (175), Expect = 8e-12
 Identities = 137/721 (19%), Positives = 254/721 (35%), Gaps = 96/721 (13%)

Query: 481  ERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM 540
            ER +   RER   + QD D   +KR  +            + P  +E+    +  +  + 
Sbjct: 79   ERPTGDLRERMKNKRQDVDTEPQKRNTEE----------SSSPVRKESSRGRHREKEDIK 128

Query: 541  VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETP 600
            ++ +       ++    T   DS          ++  + + ++ I   L    + + E  
Sbjct: 129  ITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKR 188

Query: 601  -----KKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEEL--KQ 653
                 KK+  PE+ +S++  S S    SK  + +     SS +K + K    +  L  +Q
Sbjct: 189  EEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQ 248

Query: 654  NESRTTECKQNESTIVEPKQ--------NENRLSDTKPNDNKQNNGRSETTKSRPETPKQ 705
              S+T + K+       P           +      K  D  +   R    + R    ++
Sbjct: 249  RNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQR 308

Query: 706  KGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNR 765
            +   +P +       H     +      ++        P +P++K    P   +      
Sbjct: 309  EKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSP-SPRRKRTPSPSYQRTLTPPL 367

Query: 766  RDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSD 825
            R S  P     P  S      K   PR +S   E  K R D    S+S  R H+ ++  D
Sbjct: 368  RRSASP----YPSHSLSSPQRKQSPPRHRSPMRE--KGRHDHERTSQSHDRRHERRE--D 419

Query: 826  DRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGE 885
             RG+ +R + D    R  E  +SSSR+    + D    D  +R+   ++ D RE   S +
Sbjct: 420  TRGKRDREK-DSREEREYEQDQSSSRDH---RDDREPRDGRDRRDARDTRDRRELRDSRD 475

Query: 886  QKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYL 945
             +           DS + R          S+D K +   +    T  AH     E     
Sbjct: 476  MR-----------DSREMRD--------YSRDTKESRDPRDSRSTRDAHDYRDRE----- 511

Query: 946  LGGRSGALKNFVIPKIKRDKDGN-VTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVV 1004
              GR    K    P+  R    N + +E+ + E++ E ++                    
Sbjct: 512  --GRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRN-------------------- 549

Query: 1005 LQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMP 1064
                  +   ++  DR  +SR  +  +  K S+ ++GS   S           E  S+ P
Sbjct: 550  ------ESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYP 603

Query: 1065 LCERV--KMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDR 1122
              +R   + N+ +    + + ++ E    ++ + D+   SS  RH+  +D+    E R+ 
Sbjct: 604  ERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQR-PSSPIRHQGRNDELERDERREE 662

Query: 1123 R--SSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKK 1180
            R     D RR   + E  R     R R R        +      L     + +++E++K+
Sbjct: 663  RRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKE 722

Query: 1181 R 1181
            R
Sbjct: 723  R 723



 Score = 50.1 bits (118), Expect = 3e-05
 Identities = 95/497 (19%), Positives = 178/497 (35%), Gaps = 62/497 (12%)

Query: 441  TSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIE-RERFSKEVQDKD 499
            +SV  ++ QT ++++ +  +Q          D +   +  +RE++    +   K+ + + 
Sbjct: 915  SSVDKQREQTEILESSRMRAQ----------DIIGHHQSEDRETSDRAHDENKKKAKIQK 964

Query: 500  KPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQAGRVDSQASITQ 559
            KP+KK+K+D       G   GN   + E G   +  +                      Q
Sbjct: 965  KPIKKKKEDDV-----GIERGNIETTSEDGQVFSPKKG---------------------Q 998

Query: 560  DSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESR 619
               SI+K  + K   D+ +S    D   + +S  +  P TP   +  EL   EM   ++ 
Sbjct: 999  KKKSIEKKRK-KSKGDSDIS----DEEAAQQSKKKRGPRTPPITTKEELV--EMCNGKNG 1051

Query: 620  LAE-SKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRL 678
            + E S+  E+      S E+  +    T+ E      +  +      S +  P       
Sbjct: 1052 ILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTATATTPGSTPSPLSSLLPPPPPVATAT 1111

Query: 679  SDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQ---KSDGHPETPKQKGDGRPET 735
            + T P         + T+ S          +   T        D H +  + + + + ET
Sbjct: 1112 ATTVPATLAATTAAAATSFSTSAITISTSATPTNTTNNTFANEDSHRKCHRTRVE-KVET 1170

Query: 736  PKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKS 795
            P    E          +       +R +    SG+  +       +   D       L S
Sbjct: 1171 PHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHS 1230

Query: 796  -----ERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSS 850
                 E+ ++L+   + +S  + L+R   ++  S DR +S  H    SR   PE    S 
Sbjct: 1231 GSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSH---SSRRSSPE----SD 1283

Query: 851  RNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGF 910
            R  H         D+L+ + R+E    RER     ++   D    K    N+ R D+L  
Sbjct: 1284 RQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDR-DRLRE 1342

Query: 911  KSPTSKDDKRTEGNKSK 927
            +    + DKR + ++ +
Sbjct: 1343 RERERERDKRRDLDRER 1359



 Score = 49.3 bits (116), Expect = 5e-05
 Identities = 96/452 (21%), Positives = 166/452 (36%), Gaps = 48/452 (10%)

Query: 721  HPETPKQKGDGR-----PETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEK 775
            H  +P+ KG        PE P      R +  +Q  +  P+        +R++ + S+  
Sbjct: 61   HGPSPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQ--------KRNTEESSSPV 112

Query: 776  KPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRG 835
            + E S+ +   K D    K    E+ ++  +     E+ R D DN   + D         
Sbjct: 113  RKESSRGRHREKEDIKITKERTPESEEENVEW----ETNRDDSDNGDINYDYVHELSLEM 168

Query: 836  DQSRVRRP----ETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPD 891
             + +++R     E      R E  IK + S   ++ R     S   R+   S ++KS P 
Sbjct: 169  KRQKIQRELMKLEQENMEKREEIIIKKEVSP--EVVRSKLSPSPSLRKSSKSPKRKSSPK 226

Query: 892  SPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSG 951
            S    + D   S        SP     + ++ N+SK    +  P      P  +  G+  
Sbjct: 227  SSSASKKDRKTS-----AVSSPLLDQQRNSKTNQSKKKGPRT-PSPPPPIPEDIALGKKY 280

Query: 952  ALKNFVIPKIK-RDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSL 1010
              K  V  +I+ + +DG      +  E + E +DK           +   P+      S 
Sbjct: 281  KEKYKVKDRIEEKTRDGK--DRGRDFERQREKRDKPRS---TSPAGQHHSPISSRHHSSS 335

Query: 1011 DDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVK 1070
                  I+      R      K  PS S + ++   + +   P     + S     +R +
Sbjct: 336  SQSGSSIQRHSPSPRR-----KRTPSPSYQRTLTPPLRRSASPYPSHSLSSP----QRKQ 386

Query: 1071 MNKRKRSTVNEKPKYAEISSDEDNDS-DEAFESSRKRHKKDDDKAWEYE-ERDRRSSGDH 1128
               R RS + EK ++    + + +D   E  E +R +  ++ D   E E E+D+ SS DH
Sbjct: 387  SPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDH 446

Query: 1129 RRSGHSHEG--RRSSGGGRYRNRSPSDSDMED 1158
            R      +G  RR +   R R       DM D
Sbjct: 447  RDDREPRDGRDRRDARDTRDRRELRDSRDMRD 478



 Score = 42.7 bits (99), Expect = 0.005
 Identities = 41/180 (22%), Positives = 78/180 (43%), Gaps = 21/180 (11%)

Query: 1015 KLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAE-IESTMPLCERVKMNK 1073
            K+ K+R  +S       +     S+ G I+   + EL  E+  + I+  +   E+  M K
Sbjct: 128  KITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEK 187

Query: 1074 RKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSG------D 1127
            R+   + +K    E+   + + S    +SS+   +K   K+    ++DR++S       D
Sbjct: 188  REEIII-KKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLD 246

Query: 1128 HRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPK 1187
             +R+  +++ ++         R+PS        PPP   ++A   K KEK K +   E K
Sbjct: 247  QQRNSKTNQSKKKGP------RTPSP-------PPPIPEDIALGKKYKEKYKVKDRIEEK 293



 Score = 41.2 bits (95), Expect = 0.015
 Identities = 76/343 (22%), Positives = 121/343 (35%), Gaps = 46/343 (13%)

Query: 828  GESERHRGDQSRVRR-PETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQ 886
            G S R +G  S  RR PE      R     K     T+  +R     S   R+  S G  
Sbjct: 62   GPSPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRH 121

Query: 887  KSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLL 946
            + + D    K+             ++P S+++        + +TN+   DN      Y+ 
Sbjct: 122  REKEDIKITKE-------------RTPESEEEN------VEWETNRDDSDNGDINYDYV- 161

Query: 947  GGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQ 1006
                    + +  ++KR K   + +E  K+E   E  +K E+I     + K   P VV  
Sbjct: 162  --------HELSLEMKRQK---IQRELMKLEQ--ENMEKREEI----IIKKEVSPEVVRS 204

Query: 1007 KLS----LDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQ---SVLKELPPELLAEI 1059
            KLS    L    K  K +     SS      K S  +   +DQ   S   +   +     
Sbjct: 205  KLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTP 264

Query: 1060 ESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEE 1119
                P+ E + + K+ +     K +  E + D   D    FE  R++  K    +   + 
Sbjct: 265  SPPPPIPEDIALGKKYKEKYKVKDRIEEKTRD-GKDRGRDFERQREKRDKPRSTSPAGQH 323

Query: 1120 RDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPP 1162
                SS  H  S  S    +       R R+PS S     +PP
Sbjct: 324  HSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPP 366


>gi|6631100 natural killer-tumor recognition sequence [Homo sapiens]
          Length = 1462

 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 140/669 (20%), Positives = 247/669 (36%), Gaps = 75/669 (11%)

Query: 589  LKSTPENHPETPKK---KSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVE 645
            L+S+ + +  + KK    S+  L    +K  +      K +E+R     SS+++  +   
Sbjct: 759  LRSSGKKNSVSHKKHSSSSEKTLHSKYVKGRDRSSCVRKYSESRSSLDYSSDSEQSSVQA 818

Query: 646  TQT--EELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETP 703
            TQ+  E+ KQ +   T  KQ ++   E  ++E     +K    K+N        S+P+  
Sbjct: 819  TQSAQEKEKQGQMERTHNKQEKNRGEEKSKSERECPHSKKRTLKENLSDHLRNGSKPKRK 878

Query: 704  KQKGES--------RPETPKQKSDGHPETPKQKGDGRPETPKQKGE----SRPETPKQKN 751
               G          R  T   K+D HP + K++G+   ++  +  E     +P T    N
Sbjct: 879  NYAGSKWDSESNSERDVTKNSKNDSHPSSDKEEGEATSDSESEVSEIHIKVKPTTKSSTN 938

Query: 752  EGRPE------TPKHRHDNRRDSGKPSTEK--KPEVSKHKQDTKSDSPRLKSERAEALKQ 803
               P+      + K R       G  S  +  + +  KHK  +K +   LK E  + +K+
Sbjct: 939  TSLPDDNGAWKSSKQRTSTSDSEGSCSNSENNRGKPQKHKHGSKEN---LKREHTKKVKE 995

Query: 804  RPDGRSVSE---SLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDS 860
            +  G+   +     R+   + Q   + GE E    D  +V +    +  S N   IK + 
Sbjct: 996  KLKGKKDKKHKAPKRKQAFHWQPPLEFGEEEEEEIDDKQVTQESKEKKVSENNETIKDNI 1055

Query: 861  SKTDKLERKHRHESGDSRERPSSGEQKSRPD-----SPRVKQGDSNKSRSDKLGF---KS 912
             KT+K   +      D+    S  +Q ++ D     SP     + N +    +       
Sbjct: 1056 LKTEKSSEEDLSGKHDTVTVSSDLDQFTKDDSKLSISPTALNTEENVACLQNIQHVEESV 1115

Query: 913  PTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALK-NFVI--------PKIKR 963
            P   +D     +  ++ T       K E  S L   R      N V+        P+ + 
Sbjct: 1116 PNGVEDVLQTDDNMEICTPDRSSPAKVEETSPLGNARLDTPDINIVLKQDMATEHPQAEV 1175

Query: 964  DKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDK 1023
             K  +   E+K +   G+       +    + + G K V    +++L           DK
Sbjct: 1176 VKQESSMSESKVLGEVGKQDSSSASLASAGE-STGKKEVAEKSQINL----------IDK 1224

Query: 1024 SRSSLKPIKN--KPSKSNKGSIDQSVLKELP---PE-LLAEIESTMPLCERVKMNK-RKR 1076
                L+ + N   P+ +   +++  VL  +P   P+ L  EI+S   +      ++ RK 
Sbjct: 1225 KWKPLQGVGNLAAPNAATSSAVEVKVLTTVPEMKPQGLRIEIKSKNKVRPGSLFDEVRKT 1284

Query: 1077 STVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHE 1136
            + +N +P+  E SSDE   S +    SR   +       +   R R  S  H RS     
Sbjct: 1285 ARLNRRPRNQESSSDEQTPSRDDDSQSRSPSRSRSKSETKSRHRTRSVSYSHSRS----- 1339

Query: 1137 GRRSSGGGRYRNRSPSDSDMEDY---SPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEM 1193
             R  S    YR+RS S S    +       S S   R  K      + ++      P   
Sbjct: 1340 -RSRSSTSSYRSRSYSRSRSRGWYSRGRTRSRSSSYRSYKSHRTSSRSRSRSSSYDPHSR 1398

Query: 1194 MDSSTFKRF 1202
              S T+  +
Sbjct: 1399 SRSYTYDSY 1407



 Score = 64.7 bits (156), Expect = 1e-09
 Identities = 121/636 (19%), Positives = 222/636 (34%), Gaps = 96/636 (15%)

Query: 630  LVETKSSENKLETKVE--TQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNK 687
            ++ TKS ++  E K +  T +E    + + ++  + +  + +E +++  R    +P   +
Sbjct: 175  VLATKSIKDVFEKKRKKPTHSEGSDSSSNSSSSSESSSESELEHERSRRRKHKRRPKVKR 234

Query: 688  QNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETP 747
                R E + S  E P+ K    P+   ++SD +            E       ++ E P
Sbjct: 235  SKKRRKEASSS--EEPRNKHAMNPKGHSERSDTN------------EKRSVDSSAKREKP 280

Query: 748  KQKNEGRPETPKHRHDNRRDSGKPSTEKKPE-------VSKHKQDTKSDSPRLKSERAEA 800
              + E  P  P++R   RRD    + E +P+       VS  K        ++K      
Sbjct: 281  VVRPEEIPPVPENRFLLRRDMPVVTAEPEPKIPDVAPIVSDQKPSVSKSGRKIKGRGTIR 340

Query: 801  LKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDS 860
                P  RS SES   D D+  ++    + E  R    R  RP +    S+ +      S
Sbjct: 341  YHTPPRSRSCSES---DDDDSSETPPHWKEEMQR---LRAYRPPSGEKWSKGDKLSDPCS 394

Query: 861  SKTDKLERKHRHES-------GDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSP 913
            S+ D+     R  S        D      SG  K R    +VK     K +      K  
Sbjct: 395  SRWDERSLSQRSRSWSYNGYYSDLSTARHSGHHKKRRKEKKVKHKKKGKKQKHCRRHKQT 454

Query: 914  TSKD---DKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVT 970
              +        E +KS     K+  D +    S  L     + +++   K  +D   ++T
Sbjct: 455  KKRRILIPSDIESSKSSTRRMKSSCDRERSSRSSSLSSHHSSKRDW--SKSDKDVQSSLT 512

Query: 971  QETK---------KMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDRE 1021
              ++         +   +G  + +          ++        +  S    +K      
Sbjct: 513  HSSRDSYRSKSHSQSYSRGSSRSRTASKSSSHSRSRSKS-----RSSSKSGHRKRASKSP 567

Query: 1022 DKSRSSL---KPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRST 1078
             K+ S L   KP+K +P ++     +  V++     ++AE    +PL +    ++ K   
Sbjct: 568  RKTASQLSENKPVKTEPLRATMAQNENVVVQ----PVVAENIPVIPLSDSPPPSRWKPGQ 623

Query: 1079 VNEKPKYAEI--------------------------SSDEDNDSDEAFESSRKRHKKDDD 1112
               KP Y  I                          SS   +  ++  ES +  + K  D
Sbjct: 624  KPWKPSYERIQEMKAKTTHLLPIQSTYSLANIKETGSSSSYHKREKNSESDQSTYSKYSD 683

Query: 1113 KAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSD--------SDMEDYSPPPS 1164
            ++ E   R R  S   R    S+   RS      R+RSPS         SD    S   S
Sbjct: 684  RSSESSPRSRSRSSRSRSYSRSYTRSRSLASSHSRSRSPSSRSHSRNKYSDHSQCSRSSS 743

Query: 1165 LSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFK 1200
             + ++    ++ K++ R + +      +   SS+ K
Sbjct: 744  YTSISSDDGRRAKRRLRSSGKKNSVSHKKHSSSSEK 779



 Score = 64.7 bits (156), Expect = 1e-09
 Identities = 184/862 (21%), Positives = 329/862 (38%), Gaps = 92/862 (10%)

Query: 118  QSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSP 177
            ++G   S +K  +NS       S Y   +   SP SR    ++ S +R   +  S   S 
Sbjct: 657  ETGSSSSYHKREKNSESDQSTYSKYSDRSSESSPRSRSRSSRSRSYSRSYTRSRSLASSH 716

Query: 178  YAPQSPAGYMPYSHP-SSYTTHPQMQQASVSSPIVA-GGLRNIHDNKVSGPLSGNSANHH 235
               +SP+     SH  + Y+ H Q  ++S  + I +  G R     + SG  +  S   H
Sbjct: 717  SRSRSPSS---RSHSRNKYSDHSQCSRSSSYTSISSDDGRRAKRRLRSSGKKNSVSHKKH 773

Query: 236  ADNPRHGSSEDYLHMVHRLSSDDGDSSTMR----NAASFPLRSPQPVCSPAGSEGTPKGS 291
            +      SSE  LH  +    D   SS +R    + +S    S     S   ++   +  
Sbjct: 774  S-----SSSEKTLHSKYVKGRD--RSSCVRKYSESRSSLDYSSDSEQSSVQATQSAQEKE 826

Query: 292  RPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKK-----MKLGKDEKEQSEKAAMYD 346
            +   + ++ +    +  +       + P  K++  K+     ++ G   K ++   + +D
Sbjct: 827  KQGQMERTHNKQEKNRGEEKSKSERECPHSKKRTLKENLSDHLRNGSKPKRKNYAGSKWD 886

Query: 347  IISSPSKDSTKLTLRLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPIT 406
              S+  +D TK +   S   S   D++E   +    S VSE  I   V+   ++S     
Sbjct: 887  SESNSERDVTKNSKNDSHPSS---DKEEGEATSDSESEVSE--IHIKVKPTTKSSTNTSL 941

Query: 407  PQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIY 466
            P D     N A   S+Q  +           + N     K    S    +++ +++  + 
Sbjct: 942  PDD-----NGAWKSSKQRTSTSDSEGSCSNSENNRGKPQKHKHGSKENLKREHTKK--VK 994

Query: 467  DEVELDALAEIERIERESAIERE---RFSKEVQDK--DKPLKKRKQDSYPQEAGGATGGN 521
            ++++     + +  +R+ A   +    F +E +++  DK + +  ++    E       N
Sbjct: 995  EKLKGKKDKKHKAPKRKQAFHWQPPLEFGEEEEEEIDDKQVTQESKEKKVSENNETIKDN 1054

Query: 522  RPASQETGSTG-NGSRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSV 580
               ++++     +G    + VS DL Q  + DS+ SI   S +    EE   C       
Sbjct: 1055 ILKTEKSSEEDLSGKHDTVTVSSDLDQFTKDDSKLSI---SPTALNTEENVAC------- 1104

Query: 581  LQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKL 640
              ++I    +S P    +  +   + E+   + + S +++ E+ P  N  ++T      L
Sbjct: 1105 -LQNIQHVEESVPNGVEDVLQTDDNMEICTPD-RSSPAKVEETSPLGNARLDTPDINIVL 1162

Query: 641  ETKVET---QTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTK 697
            +  + T   Q E +KQ ES  +E K       +   + +  S  +    K+   +S+   
Sbjct: 1163 KQDMATEHPQAEVVKQ-ESSMSESKVLGEVGKQDSSSASLASAGESTGKKEVAEKSQINL 1221

Query: 698  SRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRP-- 755
               +    +G      P   +    E            P+ K +      K KN+ RP  
Sbjct: 1222 IDKKWKPLQGVGNLAAPNAATSSAVEVKV-----LTTVPEMKPQGLRIEIKSKNKVRPGS 1276

Query: 756  ---ETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSE 812
               E  K    NRR   + S+  +   S+   D++S SP     ++E  K R   RSVS 
Sbjct: 1277 LFDEVRKTARLNRRPRNQESSSDEQTPSR-DDDSQSRSPSRSRSKSET-KSRHRTRSVSY 1334

Query: 813  SLRRDHDNKQKSDDRGES---ERHRGDQSRVR---RPETLRS--SSRNEHGIKSDSSKTD 864
            S  R       S  R  S    R RG  SR R   R  + RS  S R     +S SS  D
Sbjct: 1335 SHSRSRSRSSTSSYRSRSYSRSRSRGWYSRGRTRSRSSSYRSYKSHRTSSRSRSRSSSYD 1394

Query: 865  --KLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTE 922
                 R + ++S  SR R  S  Q+S  DS    +  + +SRS              R+ 
Sbjct: 1395 PHSRSRSYTYDSYYSRSRSRSRSQRS--DSYHRGRSYNRRSRS-------------CRSY 1439

Query: 923  GNKSKVDTNKAHPDNKAEFPSY 944
            G+ S+ D + +H  + +E   Y
Sbjct: 1440 GSDSESDRSYSHHRSPSESSRY 1461



 Score = 57.8 bits (138), Expect = 2e-07
 Identities = 159/812 (19%), Positives = 276/812 (33%), Gaps = 119/812 (14%)

Query: 470  ELDALAEIERIERESAIERERFSK--EVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQE 527
            E  + +   + E+ S  ++  +SK  +   +  P  + +       +   T     AS  
Sbjct: 657  ETGSSSSYHKREKNSESDQSTYSKYSDRSSESSPRSRSRSSRSRSYSRSYTRSRSLASSH 716

Query: 528  TGSTGNGSRPALMVSIDLH-QAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIV 586
            + S    SR         H Q  R  S  SI+  SD  ++ +   + +    SV  +   
Sbjct: 717  SRSRSPSSRSHSRNKYSDHSQCSRSSSYTSIS--SDDGRRAKRRLRSSGKKNSVSHKKHS 774

Query: 587  GSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVET 646
             S + T  +     + +S      SE   S S L  S  +E   V+   S  + E + + 
Sbjct: 775  SSSEKTLHSKYVKGRDRSSCVRKYSE---SRSSLDYSSDSEQSSVQATQSAQEKEKQGQM 831

Query: 647  QTEELKQNESRTTECKQNESTIVEPKQN--ENRLSDTKPNDNK-------------QNNG 691
            +    KQ ++R  E  ++E      K+   +  LSD   N +K             ++N 
Sbjct: 832  ERTHNKQEKNRGEEKSKSERECPHSKKRTLKENLSDHLRNGSKPKRKNYAGSKWDSESNS 891

Query: 692  RSETTK-----SRPETPKQKGESRPETPKQKSDGHPET-PKQKGDGRPETPKQKG---ES 742
              + TK     S P + K++GE+  ++  + S+ H +  P  K       P   G    S
Sbjct: 892  ERDVTKNSKNDSHPSSDKEEGEATSDSESEVSEIHIKVKPTTKSSTNTSLPDDNGAWKSS 951

Query: 743  RPETPKQKNEG--------RPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLK 794
            +  T    +EG        R +  KH+H ++ +  +  T+K  E  K K+D K  +P+ K
Sbjct: 952  KQRTSTSDSEGSCSNSENNRGKPQKHKHGSKENLKREHTKKVKEKLKGKKDKKHKAPKRK 1011

Query: 795  S------------ERAEALK-----QRPDGRSVSESLRRDHDN---KQKSDDRGESERH- 833
                         E  E +      Q    + VSE+     DN    +KS +   S +H 
Sbjct: 1012 QAFHWQPPLEFGEEEEEEIDDKQVTQESKEKKVSENNETIKDNILKTEKSSEEDLSGKHD 1071

Query: 834  -----------RGDQSRVRRPETLRSSSRN--------------EHGIKSDSSKTDKLER 868
                         D S++    T  ++  N               +G++      D +E 
Sbjct: 1072 TVTVSSDLDQFTKDDSKLSISPTALNTEENVACLQNIQHVEESVPNGVEDVLQTDDNMEI 1131

Query: 869  KHRHESGDSRERPSSGEQKSRPDSPRVK---QGDSNKSRSDKLGFKSPTSKDDKRTEGNK 925
                 S  ++   +S    +R D+P +    + D           K  +S  + +  G  
Sbjct: 1132 CTPDRSSPAKVEETSPLGNARLDTPDINIVLKQDMATEHPQAEVVKQESSMSESKVLGEV 1191

Query: 926  SKVDTNKAHPDNKAEFPSYLLGGRSGALK-------------NFVIPKIKRDKDGNVTQE 972
             K D++ A   +  E            +              N   P         V   
Sbjct: 1192 GKQDSSSASLASAGESTGKKEVAEKSQINLIDKKWKPLQGVGNLAAPNAATSSAVEVKVL 1251

Query: 973  TKKMEMKGE-------PKDKVEKIGLVEDLNKGAK----PVVVLQKLSLDDVQKLIKDRE 1021
            T   EMK +        K+KV    L +++ K A+    P     + S  D Q   +D +
Sbjct: 1252 TTVPEMKPQGLRIEIKSKNKVRPGSLFDEVRKTARLNRRP---RNQESSSDEQTPSRDDD 1308

Query: 1022 DKSRSSLKPIKNKPSKSNKG--SIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTV 1079
             +SRS  +      +KS     S+  S  +       +   S      R +    +  T 
Sbjct: 1309 SQSRSPSRSRSKSETKSRHRTRSVSYSHSRSRSRSSTSSYRSRSYSRSRSRGWYSRGRTR 1368

Query: 1080 NEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRR 1139
            +    Y    S   +    +  SS   H +     ++      RS    +RS   H GR 
Sbjct: 1369 SRSSSYRSYKSHRTSSRSRSRSSSYDPHSRSRSYTYDSYYSRSRSRSRSQRSDSYHRGRS 1428

Query: 1140 SSGGGRYRNRSPSDSDME-DYSPPPSLSEVAR 1170
             +   R      SDS+ +  YS   S SE +R
Sbjct: 1429 YNRRSRSCRSYGSDSESDRSYSHHRSPSESSR 1460



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 113/585 (19%), Positives = 215/585 (36%), Gaps = 53/585 (9%)

Query: 583  EDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLET 642
            +D+  SL  +  +   +           S  + +    + S+        +KS   K  +
Sbjct: 505  KDVQSSLTHSSRDSYRSKSHSQSYSRGSSRSRTASKSSSHSRSRSKSRSSSKSGHRKRAS 564

Query: 643  KVETQT-EELKQNESRTTE-----CKQNESTIVEPKQNEN----RLSDTKPNDNKQNNGR 692
            K   +T  +L +N+   TE       QNE+ +V+P   EN     LSD+ P  ++   G+
Sbjct: 565  KSPRKTASQLSENKPVKTEPLRATMAQNENVVVQPVVAENIPVIPLSDSPP-PSRWKPGQ 623

Query: 693  SETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNE 752
                 S     + K ++    P Q +                  K+ G S     ++KN 
Sbjct: 624  KPWKPSYERIQEMKAKTTHLLPIQSTYSLANI------------KETGSSSSYHKREKNS 671

Query: 753  GRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSE 812
               ++   ++ +R     P +  +   S+    + + S  L S  + +  + P  RS S 
Sbjct: 672  ESDQSTYSKYSDRSSESSPRSRSRSSRSRSYSRSYTRSRSLASSHSRS--RSPSSRSHSR 729

Query: 813  SLRRDHDNKQKSDDRG--ESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKH 870
            +   DH    +S       S+  R  + R+R      S S  +H   S+ +   K   K 
Sbjct: 730  NKYSDHSQCSRSSSYTSISSDDGRRAKRRLRSSGKKNSVSHKKHSSSSEKTLHSKYV-KG 788

Query: 871  RHESGDSR---ERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSK 927
            R  S   R   E  SS +  S  +   V+   S + +  +   +   +K +K     KSK
Sbjct: 789  RDRSSCVRKYSESRSSLDYSSDSEQSSVQATQSAQEKEKQGQMERTHNKQEKNRGEEKSK 848

Query: 928  VDTNKAHPDN---KAEFPSYLLGGRSGALKNFVIPK------IKRDKDGNVTQETKKMEM 978
             +    H      K     +L  G     KN+   K       +RD   N   ++     
Sbjct: 849  SERECPHSKKRTLKENLSDHLRNGSKPKRKNYAGSKWDSESNSERDVTKNSKNDSHPSSD 908

Query: 979  KGEPKDKVEKIGLVEDLNKGAKPVVVLQ-KLSLDD--------VQKLIKDREDKSRSSLK 1029
            K E +   +    V +++   KP        SL D         Q+      + S S+ +
Sbjct: 909  KEEGEATSDSESEVSEIHIKVKPTTKSSTNTSLPDDNGAWKSSKQRTSTSDSEGSCSNSE 968

Query: 1030 PIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKP-KYAEI 1088
              + KP K   GS  +++ +E   ++  +++      ++ K  KRK++   + P ++ E 
Sbjct: 969  NNRGKPQKHKHGS-KENLKREHTKKVKEKLKGKKD--KKHKAPKRKQAFHWQPPLEFGEE 1025

Query: 1089 SSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGH 1133
              +E +D     ES  K+  ++++   +   +  +SS +     H
Sbjct: 1026 EEEEIDDKQVTQESKEKKVSENNETIKDNILKTEKSSEEDLSGKH 1070



 Score = 49.7 bits (117), Expect = 4e-05
 Identities = 129/651 (19%), Positives = 220/651 (33%), Gaps = 90/651 (13%)

Query: 595  NHPETPKKKSDPELS-KSEMKQSESRLAESKPNENRLVETKSSE---NKLETKVETQTEE 650
            N   + +  S+ EL  +   ++   R  + K ++ R  E  SSE   NK     +  +E 
Sbjct: 203  NSSSSSESSSESELEHERSRRRKHKRRPKVKRSKKRRKEASSSEEPRNKHAMNPKGHSER 262

Query: 651  LKQNESRTTECK-QNESTIVEPKQ----NENR------------------------LSDT 681
               NE R+ +   + E  +V P++     ENR                        +SD 
Sbjct: 263  SDTNEKRSVDSSAKREKPVVRPEEIPPVPENRFLLRRDMPVVTAEPEPKIPDVAPIVSDQ 322

Query: 682  KPNDNKQNN---GRSETTKSRPETPKQKGES------------RPETPKQKSDGHPETPK 726
            KP+ +K      GR       P   +   ES            + E  + ++   P   K
Sbjct: 323  KPSVSKSGRKIKGRGTIRYHTPPRSRSCSESDDDDSSETPPHWKEEMQRLRAYRPPSGEK 382

Query: 727  -QKGDGRPETPKQKGESRPETPKQKNEGRP------ETPKH--RHDNRRDSGKPSTEKKP 777
              KGD   +    + + R  + + ++           T +H   H  RR   K   +KK 
Sbjct: 383  WSKGDKLSDPCSSRWDERSLSQRSRSWSYNGYYSDLSTARHSGHHKKRRKEKKVKHKKKG 442

Query: 778  EVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQ 837
            +  KH +  K    R     ++    +   R +  S  R+  ++  S     S +    +
Sbjct: 443  KKQKHCRRHKQTKKRRILIPSDIESSKSSTRRMKSSCDRERSSRSSSLSSHHSSKRDWSK 502

Query: 838  SRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQ 897
            S      +L  SSR+ +  KS S           +  G SR R +S  + S     R K 
Sbjct: 503  SDKDVQSSLTHSSRDSYRSKSHSQS---------YSRGSSRSRTAS--KSSSHSRSRSKS 551

Query: 898  GDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKA-HPDNKAEFPSYLLGGRSGALKNF 956
              S+KS   K   KSP     + +E    K +  +A    N+      ++      +   
Sbjct: 552  RSSSKSGHRKRASKSPRKTASQLSENKPVKTEPLRATMAQNENVVVQPVVAENIPVIPLS 611

Query: 957  VIPKIKRDKDGNVTQE---TKKMEMKGEPKDKV---EKIGLVEDLNKGAKPVVVLQKLSL 1010
              P   R K G    +    +  EMK +    +       L      G+      ++ + 
Sbjct: 612  DSPPPSRWKPGQKPWKPSYERIQEMKAKTTHLLPIQSTYSLANIKETGSSSSYHKREKNS 671

Query: 1011 DDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVK 1070
            +  Q       D+S  S    +++ S+S   S   +  + L     +   S  P      
Sbjct: 672  ESDQSTYSKYSDRSSESSPRSRSRSSRSRSYSRSYTRSRSLAS---SHSRSRSPSSRSHS 728

Query: 1071 MNK-RKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHR 1129
             NK    S  +    Y  ISSD+   +     SS K++              ++ S    
Sbjct: 729  RNKYSDHSQCSRSSSYTSISSDDGRRAKRRLRSSGKKNSVS----------HKKHSSSSE 778

Query: 1130 RSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKK 1180
            ++ HS   +        R  S S S + DYS     S V      +EK+K+
Sbjct: 779  KTLHSKYVKGRDRSSCVRKYSESRSSL-DYSSDSEQSSVQATQSAQEKEKQ 828


>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
          Length = 494

 Score = 76.6 bits (187), Expect = 3e-13
 Identities = 82/349 (23%), Positives = 150/349 (42%), Gaps = 27/349 (7%)

Query: 602 KKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTEC 661
           K++  +L  +E+   + RL E KP   R      S ++  ++  +++   +++ SR+   
Sbjct: 154 KRALEKLDGTEVNGRKIRLVEDKPGSRR--RRSYSRSRSHSRSRSRSRHSRKSRSRSGSS 211

Query: 662 KQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETP---KQKS 718
           K + S      ++ +R S +K     Q+  RS+  KSR  + K+K  SR  +    + KS
Sbjct: 212 KSSHSKSRSRSRSGSR-SRSKSRSRSQSRSRSKKEKSRSPS-KEKSRSRSHSAGKSRSKS 269

Query: 719 DGHPETPKQKGD--GRPETPK-QKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEK 775
               E   Q  D  G+P++    + +S+ ++  +  E R E  K    +R  S + S  +
Sbjct: 270 KDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQ 329

Query: 776 KPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRG 835
               S+ K  ++S S R +S+  +  K R   R  S S  R     ++S  RG     + 
Sbjct: 330 SRSRSRSKGGSRSRS-RSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKA 388

Query: 836 DQSRVRRPE-TLRSSSRN---------EHGIKSDSSKTDKLERKHRHESGDSRERPSSGE 885
             S+ ++ E T RS SR+         EH     S +  + E ++   + ++R R S   
Sbjct: 389 GSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSR-SRSN 447

Query: 886 QKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAH 934
            KS+P+ P       ++SRS         SK   R+         +++H
Sbjct: 448 SKSKPNLP-----SESRSRSKSASKTRSRSKSRSRSASRSPSRSRSRSH 491



 Score = 66.2 bits (160), Expect = 4e-10
 Identities = 76/325 (23%), Positives = 139/325 (42%), Gaps = 34/325 (10%)

Query: 594 ENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQ 653
           E+ P + +++S    S+S  + S SR   S+ + +R   +KSS +K  ++  + +    +
Sbjct: 174 EDKPGSRRRRSYSR-SRSHSR-SRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSK 231

Query: 654 NESRT---TECKQNESTIVEPKQNENRLSDTKPNDNK---------QNNGRSETTKSR-P 700
           + SR+   +  K+ +S     +++ +R      + +K         QNN      KSR P
Sbjct: 232 SRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSP 291

Query: 701 ETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQ-------KGESRPET-----PK 748
              K K +SR  + +++ +        +G  + ++ +Q       KG SR  +      K
Sbjct: 292 SRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSK 351

Query: 749 QKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKS-DSPRLKSERAEALKQRPDG 807
            K +GR  +   R ++R  S   S  ++      K+D+K+  S + K E  +  + R   
Sbjct: 352 DKRKGRKRS---REESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPS 408

Query: 808 RSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLE 867
           RSVS+          + + RGESE    +Q    R    RS+S+++  + S+S    K  
Sbjct: 409 RSVSKEREHAKSESSQREGRGESENAGTNQETRSRS---RSNSKSKPNLPSESRSRSKSA 465

Query: 868 RKHRHESGDSRERPSSGEQKSRPDS 892
            K R  S       S    +SR  S
Sbjct: 466 SKTRSRSKSRSRSASRSPSRSRSRS 490



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 58/293 (19%), Positives = 129/293 (44%), Gaps = 22/293 (7%)

Query: 591 STPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEE 650
           S+  +H ++  +      S+S+ +      + SK  ++R    + S ++  +  +++++ 
Sbjct: 210 SSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKS 269

Query: 651 LKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESR 710
             Q E +     QN   + +PK      S +      ++  RS + + R E  K+   SR
Sbjct: 270 KDQAEEKI----QNNDNVGKPK------SRSPSRHKSKSKSRSRSQERRVEEEKRGSVSR 319

Query: 711 PETPKQKSDGHPETPKQKGDGRPET-------PKQKGESRP-ETPKQKNEGRPETPKHR- 761
             + ++         + KG  R  +        K+KG  R  E  + ++  R ++ + R 
Sbjct: 320 GRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRK 379

Query: 762 HDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSER--AEALKQRPDGRSVSESLRRDHD 819
             ++RDS   S++KK +    +  ++S S  +  ER  A++   + +GR  SE+   + +
Sbjct: 380 RGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQE 439

Query: 820 NKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRH 872
            + +S    +S+ +   +SR R     ++ SR++   +S +S++    R   H
Sbjct: 440 TRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRS-ASRSPSRSRSRSH 491



 Score = 48.5 bits (114), Expect = 9e-05
 Identities = 61/312 (19%), Positives = 108/312 (34%), Gaps = 33/312 (10%)

Query: 741  ESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEA 800
            E +P + ++++  R  +        R S K  +      S H +       R +S     
Sbjct: 174  EDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKS------RSRSRSGSR 227

Query: 801  LKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGI---K 857
             + +   RS S S  +   ++  S ++  S  H   +SR +  +      +N   +   K
Sbjct: 228  SRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPK 287

Query: 858  SDSSKTDKLERKHRHESGDSR----ERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSP 913
            S S    K + K R  S + R    +R S    +S+  S R  +  S      +   +S 
Sbjct: 288  SRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSR 347

Query: 914  TSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQET 973
            +   DKR    +S+ ++            S   G +  +       K K D D + ++  
Sbjct: 348  SKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSP 407

Query: 974  KKMEMKGEPKDKVE---KIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKP 1030
             +   K     K E   + G  E  N G                   ++   +SRS+ K 
Sbjct: 408  SRSVSKEREHAKSESSQREGRGESENAGTN-----------------QETRSRSRSNSKS 450

Query: 1031 IKNKPSKSNKGS 1042
              N PS+S   S
Sbjct: 451  KPNLPSESRSRS 462



 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 72/330 (21%), Positives = 119/330 (36%), Gaps = 29/330 (8%)

Query: 857  KSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSK 916
            K  S +     R   H    SR R S   +KSR  S   K   S      + G +S +  
Sbjct: 176  KPGSRRRRSYSRSRSHSRSRSRSRHS---RKSRSRSGSSKSSHSKSRSRSRSGSRSRSKS 232

Query: 917  DDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKM 976
              +    ++SK + +++    K+   S+  G      K+    KI+ + +    +     
Sbjct: 233  RSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPS 292

Query: 977  EMKGEPKDKVE-KIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKP 1035
              K + K +   +   VE+  +G+      Q+ SL         R+ +SRS  K      
Sbjct: 293  RHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSL---------RQSRSRSRSKGGSRSR 343

Query: 1036 SKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTV--NEKPKYAEISSDED 1093
            S+S   S D+   ++   E       +    ER +    KR +   + K K  E +    
Sbjct: 344  SRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQ 403

Query: 1094 NDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSD 1153
            + S     S  + H K        E   R   G+   +G + E R        R+RS S 
Sbjct: 404  SRSPSRSVSKEREHAKS-------ESSQREGRGESENAGTNQETRS-------RSRSNSK 449

Query: 1154 SDMEDYSPPPSLSEVARKMKKKEKQKKRKA 1183
            S     S   S S+ A K + + K + R A
Sbjct: 450  SKPNLPSESRSRSKSASKTRSRSKSRSRSA 479



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 79/368 (21%), Positives = 134/368 (36%), Gaps = 41/368 (11%)

Query: 803  QRPDGRSVSESLRRDHDNKQKSDDRGESERHRG-DQSRVRRPETLRSSSRNEHGIKSDSS 861
            ++ DG  V+    R  ++K  S  R    R R   +SR R   + +S SR+    KS  S
Sbjct: 158  EKLDGTEVNGRKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSS-KSSHS 216

Query: 862  KTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRT 921
            K+    R        SR R S    +S+ +  R    + ++SRS   G     SKD    
Sbjct: 217  KSRSRSRSGSRSRSKSRSR-SQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQA-- 273

Query: 922  EGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGE 981
               + K+  N    DN  +  S     RS +          R ++  V +E +    +G 
Sbjct: 274  ---EEKIQNN----DNVGKPKS-----RSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGR 321

Query: 982  PKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKG 1041
             ++K  +       +KG        +    D +K  K   ++SRS  +          +G
Sbjct: 322  SQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRG 381

Query: 1042 SIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEA-F 1100
            S   S                     +   +K+K+    ++ +    S     + + A  
Sbjct: 382  SKRDS---------------------KAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKS 420

Query: 1101 ESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGH--SHEGRRSSGGGRYRNRSPSDSDMED 1158
            ESS++  + + + A   +E   RS  + +   +  S    RS    + R+RS S S    
Sbjct: 421  ESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSAS 480

Query: 1159 YSPPPSLS 1166
             SP  S S
Sbjct: 481  RSPSRSRS 488



 Score = 33.5 bits (75), Expect = 3.0
 Identities = 45/200 (22%), Positives = 71/200 (35%), Gaps = 11/200 (5%)

Query: 1018 KDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRS 1077
            K    KSRS  +      SKS   S  +S  K+      ++ +S        K   + + 
Sbjct: 212  KSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKD 271

Query: 1078 TVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEG 1137
               EK +  +      + S    +S  K   +  ++  E E+R   S G  +        
Sbjct: 272  QAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSR 331

Query: 1138 RRSSGGGRYRNRSPSDSDMEDYSPPPSLSEV-----ARKMKKKEKQKKR------KAYEP 1186
             RS   G  R+RS S S  +D       S       +R   K E+ +KR      KA   
Sbjct: 332  SRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSS 391

Query: 1187 KLTPEEMMDSSTFKRFTASI 1206
            K   +E  D S  +  + S+
Sbjct: 392  KKKKKEDTDRSQSRSPSRSV 411



 Score = 32.7 bits (73), Expect = 5.2
 Identities = 33/157 (21%), Positives = 62/157 (39%), Gaps = 11/157 (7%)

Query: 1038 SNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKP------KYAEISSD 1091
            ++KG  ++ V++ +     ++++  +   +  ++N RK   V +KP       Y+  S  
Sbjct: 135  AHKGRKNEGVIEFVS---YSDMKRALEKLDGTEVNGRKIRLVEDKPGSRRRRSYSR-SRS 190

Query: 1092 EDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSP 1151
                   +  S + R +    K+   + R R  SG   RS      +  S   + ++RSP
Sbjct: 191  HSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSP 250

Query: 1152 SDSDMEDYSPPPSLSEVARKMKKKEK-QKKRKAYEPK 1187
            S       S     S    K + +EK Q      +PK
Sbjct: 251  SKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPK 287


>gi|217330641 IWS1 homolog [Homo sapiens]
          Length = 819

 Score = 74.3 bits (181), Expect = 2e-12
 Identities = 140/695 (20%), Positives = 263/695 (37%), Gaps = 92/695 (13%)

Query: 581  LQEDIVGSLKSTPENHPETPKKKSDPELSKSE-MKQSES----RLAESKPNENRLVETKS 635
            + E   GS   + E H E      +  L K   +  SE+     L  S      L   K 
Sbjct: 33   VNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHRQKD 92

Query: 636  SENKLETKVE-----TQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNN 690
            S+++ E + E     ++ E++ Q+ S  +E ++         +NE  L+    +   ++ 
Sbjct: 93   SDSESEERAEPPASDSENEDVNQHGS-DSESEETRKLPGSDSENEELLNGHASDSENEDV 151

Query: 691  GRSETTKSRPE----TPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPET 746
            G+   + S  E    +P    E+      Q SD   E P      R +    + E  P+ 
Sbjct: 152  GKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPP-----RHQASDSENEEPPK- 205

Query: 747  PKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPD 806
            P+  +    E PK +      S   S E     +   ++ +   PR+    +E   +   
Sbjct: 206  PRMSDSESEELPKPQV-----SDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQA 260

Query: 807  GRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRN-EHGIKSDSSKTDK 865
              S +E L +   +  +S+D   ++    +   + +P    S S   + G  SDS   D 
Sbjct: 261  SDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDA 320

Query: 866  LERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNK 925
               K + ES D  +R + GE     D+        + S  D+  F S  S+++   E  K
Sbjct: 321  SRHKQKPESDDDSDRENKGE-----DTEMQNDSFHSDSHMDRKKFHSSDSEEE---EHKK 372

Query: 926  SKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDK 985
             K+D+++   + + E                   K+ + K   ++      + + E K  
Sbjct: 373  QKMDSDEDEKEGEEE-------------------KVAKRKAAVLS------DSEDEEKAS 407

Query: 986  VEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQ 1045
             +K  +V D +      V     S    + +  D E+++   L   KN+  K   GS  +
Sbjct: 408  AKKSRVVSDADDSDSDAV--SDKSGKREKTIASDSEEEAGKELSDKKNE-EKDLFGSDSE 464

Query: 1046 SVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRK 1105
            S  +E    L+A+I       E  +     +  + E+    ++   ED+DSD+  +  R 
Sbjct: 465  SGNEE--ENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIK--RG 520

Query: 1106 RHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSL 1165
            +H    D   ++E   +      R+   S + RR+  GG +     SD+D    +    +
Sbjct: 521  KHM---DFLSDFEMMLQ------RKKSMSGKRRRNRDGGTF----ISDADDVVSAMIVKM 567

Query: 1166 SEVARKMKKKEKQKKRKAYEPKLTP--------EEMMDSSTFKRFTASIENILDNLEDMD 1217
            +E A + ++   QKK    +  L P        +++ ++       ++I+  L  L D  
Sbjct: 568  NEAAEEDRQLNNQKKPALKKLTLLPAVVMHLKKQDLKETFIDSGVMSAIKEWLSPLPDRS 627

Query: 1218 FTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMG 1252
              A     +I +ELL    +L  +  E+ K   +G
Sbjct: 628  LPAL----KIREELLKILQELPSVSQETLKHSGIG 658



 Score = 63.2 bits (152), Expect = 4e-09
 Identities = 104/509 (20%), Positives = 184/509 (36%), Gaps = 63/509 (12%)

Query: 456 QQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQE-- 513
           +  +++Q    D   ++  +E E  +RE  + +     +  + D+PL     DS  +E  
Sbjct: 30  EDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTD-SENDEPLNLNASDSESEELH 88

Query: 514 ------AGGATGGNRPASQ-------ETGSTGNGSRPALMVSIDLHQAGRVDSQASITQD 560
                 +        PAS        + GS         +   D      ++  AS +++
Sbjct: 89  RQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSEN 148

Query: 561 SDSIKKP---EEIKQCNDAPVS------VLQEDIVGSLKSTPENHPETPKKKSDPELSKS 611
            D  K P    EI++   +P S       L+  I  S    P  H  +  +  +P   K 
Sbjct: 149 EDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEP--PKP 206

Query: 612 EMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEP 671
            M  SES   E  P + ++ +++S E       +++ EEL +     +E +         
Sbjct: 207 RMSDSES---EELP-KPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASD 262

Query: 672 KQNEN----RLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETP-- 725
            +NE     R+SD++  D  +N       +  P+      ES        SD   E    
Sbjct: 263 SENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASR 322

Query: 726 -KQKGDGRPETPKQ-KGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHK 783
            KQK +   ++ ++ KGE   +T  Q +    ++   R        +    KK ++   +
Sbjct: 323 HKQKPESDDDSDRENKGE---DTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDE 379

Query: 784 QDTKSDSPRLKSERAEALKQRPDGRSVSESLRR------DHDNKQKSDDRGESERHRGDQ 837
            + + +  ++   +A  L    D    S    R      D D+   SD  G+ E+     
Sbjct: 380 DEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASD 439

Query: 838 SRVRRPETLRSSSRNEH----GIKSDS-SKTDKLERKHRHESGDSRERPSSG-------E 885
           S     + L S  +NE     G  S+S ++ + L      ESGD  E   +G       E
Sbjct: 440 SEEEAGKEL-SDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEE 498

Query: 886 QKSRPDSPRVKQGDS--NKSRSDKLGFKS 912
           +K        +  DS  N  R   + F S
Sbjct: 499 EKGETQVKEAEDSDSDDNIKRGKHMDFLS 527



 Score = 41.2 bits (95), Expect = 0.015
 Identities = 71/284 (25%), Positives = 105/284 (36%), Gaps = 59/284 (20%)

Query: 133 MHSSPASSNYQQTTISH--SPSSRFVPPQTSSGNRFMPQQNSPVPSPYAPQSPAGYMPYS 190
           +  SPAS +  +  +    S S    PP+  + +     +N   P P    S +  +P  
Sbjct: 164 LQKSPASDSETEDALKPQISDSESEEPPRHQASD----SENEEPPKPRMSDSESEELPKP 219

Query: 191 HPS-SYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLH 249
             S S +  P   QAS S            + ++  P   +S +   D PRH +S+    
Sbjct: 220 QVSDSESEEPPRHQASDSE-----------NEELPKPRISDSESE--DPPRHQASDSENE 266

Query: 250 MVHRLSSDDGDSSTM-RNAASFPLRS--PQPVCSPAGSEGTPKG--------------SR 292
            + +    D +S    RN AS       P+P  S + SEG  KG               +
Sbjct: 267 ELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQK 326

Query: 293 PP-------------LILQSQSLPCSSPRDVPPDILLDSPERKQKKQKK-----MKLGKD 334
           P                +Q+ S    S  D       DS E + KKQK       K G++
Sbjct: 327 PESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEE 386

Query: 335 EKEQSEKAAMYDIISSPSKDSTKLTLRLSRVRSSDMDQQEDMIS 378
           EK    KAA    + S S+D  K + + SRV S   D   D +S
Sbjct: 387 EKVAKRKAA----VLSDSEDEEKASAKKSRVVSDADDSDSDAVS 426


>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
           [Homo sapiens]
          Length = 651

 Score = 73.6 bits (179), Expect = 3e-12
 Identities = 71/331 (21%), Positives = 138/331 (41%), Gaps = 34/331 (10%)

Query: 590 KSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTE 649
           K   ++  +  K     +  K   K +ES  AES  +++   +TK  + KL+       +
Sbjct: 304 KDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKK------D 357

Query: 650 ELKQNESRTTECKQNESTIVEPKQNENR-LSDTKPNDNKQNNGRSETTKSRPETPKQKGE 708
           + K++  +  E    ES   +  +N++R L     ND+K+ + +  T  +  E+  +  E
Sbjct: 358 DKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKE 417

Query: 709 SRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDS 768
           S+ +  K K D   +  K   +    T     +S P+   +K  G+ +  K + D+++D 
Sbjct: 418 SQKDEKKDKKDSKTDNKKSVKNDEEST---DADSEPKGDSKK--GKKDEKKGKKDSKKDD 472

Query: 769 GKPSTEKKPEVSKHKQD--TKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQK--- 823
            K   +K  E ++ + D   K D    K ++      + D R  +ES   + D   K   
Sbjct: 473 KKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGF 532

Query: 824 --------SDDRGESERHR-GDQSRVRRPETLRSSSRNE-----HGIKSDSSKTDKLERK 869
                   SD   E   ++ G + ++   +   ++S+ E      G +  S KT   E+ 
Sbjct: 533 KTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKG 592

Query: 870 HRHESG---DSRERPSSGEQKSRPDSPRVKQ 897
            +  +G    SRE+P     +    SP+V++
Sbjct: 593 EKASTGRVPPSREKPPLPACEPSLPSPKVRR 623



 Score = 62.4 bits (150), Expect = 6e-09
 Identities = 89/481 (18%), Positives = 194/481 (40%), Gaps = 38/481 (7%)

Query: 492 SKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQAGRV 551
           SK++ + +K  ++ + D  P ++      ++  S+ +  T   S+ +  VS +  Q  + 
Sbjct: 144 SKQIVE-EKTKRQNEADKTPLKSSHENEQSKK-SKSSSETNPESQNSKTVSKNCSQKDKK 201

Query: 552 DSQASITQDSDSI-------KKPEEIKQCNDAPVSVLQED--------IVGSLKSTPENH 596
           DS+ S   +++ +       K  +  K  ND    +  E+        +VG       N 
Sbjct: 202 DSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINF 261

Query: 597 PETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEE-LKQNE 655
               +  S        +K ++    ++K N  +  + +S ++K   K   + ++ +K+++
Sbjct: 262 DAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDD 321

Query: 656 SRTTECKQNESTIVEPKQNENRLSDTKPNDNK-QNNGRSETTKSRPE-TPKQKGESRPET 713
            +    K  EST  E   +++   DTK +  K + + + + TK  PE T  + G+++   
Sbjct: 322 KKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDAR 381

Query: 714 PKQKS-DGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRR------ 766
              ++     +   +K D +  T     ES  E+ + + + + +    + DN++      
Sbjct: 382 NDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDE 441

Query: 767 DSGKPSTEKKPEVSKHKQDTKSDSP-RLKSERAEALKQRPDGRSVSESLRRDHDNKQKSD 825
           +S    +E K +  K K+D K       K ++ +  K+  +   +   L    D K   +
Sbjct: 442 ESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKE 501

Query: 826 DRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGE 885
            +G  +    D  +  R +T  + +  +   K+    + K++     ES +S  +P  G 
Sbjct: 502 KKGSKK----DIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDT-ESEESLYKP--GA 554

Query: 886 QKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKS---KVDTNKAHPDNKAEFP 942
           +K   +S         +    K GF+  + K     +G K+   +V  ++  P   A  P
Sbjct: 555 KKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKASTGRVPPSREKPPLPACEP 614

Query: 943 S 943
           S
Sbjct: 615 S 615



 Score = 62.0 bits (149), Expect = 8e-09
 Identities = 104/541 (19%), Positives = 203/541 (37%), Gaps = 85/541 (15%)

Query: 590  KSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTE 649
            + TP  H  T K      L K+E K+S+     +   ++   +  S     E+K   + +
Sbjct: 96   EQTPFRHLYTSKT----HLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEK 151

Query: 650  ELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGES 709
              +QNE+  T  K +     E +Q++   S ++ N   QN+       S+ +    K   
Sbjct: 152  TKRQNEADKTPLKSSH----ENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSK 207

Query: 710  RPETPKQKSDGHPETP----KQKGDGRPETPKQK----------GESRPET--------- 746
            +  T    +  +P+      K   D   E   +           G+S  E+         
Sbjct: 208  KTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRN 267

Query: 747  ---PKQKNEGRPETPKHRHDNRRDSGKPST-------EKKPEVSKHKQDTKSDSPR--LK 794
                  KN     T   + D ++++ K S        + K +  K K++ K D  +  +K
Sbjct: 268  YSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVK 327

Query: 795  SERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEH 854
             +      +  D +   +  ++D    +K D + +++++         PE+  + S +  
Sbjct: 328  KDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKY---------PESTDTESGDAK 378

Query: 855  GIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPT 914
              ++DS    K   K+  +  D+++   S + +S  +S   ++ +    +  K   K   
Sbjct: 379  DARNDSRNLKKAS-KNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSV 437

Query: 915  SKDDKRTEG-NKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQET 973
              D++ T+  ++ K D+ K   D K         G+  + K+    K    K+   T+  
Sbjct: 438  KNDEESTDADSEPKGDSKKGKKDEKK--------GKKDSKKD--DKKKDAKKNAESTEME 487

Query: 974  KKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKL-------IKDREDKSRS 1026
              +E+K + K   EK G  +D+ K A+          D+  K        IK  + +S  
Sbjct: 488  SDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEE 547

Query: 1027 SL-KPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKY 1085
            SL KP   K    + G+   S ++ L  +    + S             K++T NEK + 
Sbjct: 548  SLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSS-------------KKTTFNEKGEK 594

Query: 1086 A 1086
            A
Sbjct: 595  A 595



 Score = 60.8 bits (146), Expect = 2e-08
 Identities = 133/606 (21%), Positives = 218/606 (35%), Gaps = 131/606 (21%)

Query: 693  SETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNE 752
            S+T   + E  K K E +  TP +K        K+KG      P+ K +   E  K++NE
Sbjct: 106  SKTHLKKAEYKKSKDE-KGGTPLKKDS------KKKGGSYATNPESK-QIVEEKTKRQNE 157

Query: 753  GRPETPKHRHDNRRDS-GKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVS 811
                  K  H+N +    K S+E  PE    K  +K+ S + K +   + K   +     
Sbjct: 158  ADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTK 217

Query: 812  ESLRRDHDNKQKSDDR-----GESERH--------RGDQSRVRRPETLRSSSRNEHGIKS 858
             + ++D    + S+D       E+  +        + D   +     LR+ S+N    K+
Sbjct: 218  NNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNS--KN 275

Query: 859  DSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDD 918
             S K  K  +K                +K+   S   +  DS  ++ D    K    KDD
Sbjct: 276  YSLKYTKYTKKDT--------------KKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDD 321

Query: 919  KRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEM 978
            K+ +  K    T+    D+K E                     ++D     T++ KK   
Sbjct: 322  KKKDVKKDTESTDAESGDSKDE---------------------RKD-----TKKDKKKLK 355

Query: 979  KGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKS 1038
            K + K   +K     D   G                   KD  + SR+  K  KN   K 
Sbjct: 356  KDDKKKDTKKYPESTDTESGDA-----------------KDARNDSRNLKKASKNDDKKK 398

Query: 1039 NKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDN-DSD 1097
            +   I  S   E      +E+ES     +  K +K+   T N+K     + +DE++ D+D
Sbjct: 399  DAKKITFSTDSE------SELESKESQKDE-KKDKKDSKTDNKK----SVKNDEESTDAD 447

Query: 1098 EAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDME 1157
               +   K+ KKD+ K  +  ++D +   D +++  S E                +SD+E
Sbjct: 448  SEPKGDSKKGKKDEKKGKKDSKKDDKKK-DAKKNAESTE---------------MESDLE 491

Query: 1158 DYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMD 1217
                        +K KK  K+KK    + K    +  + ST   F  S +        + 
Sbjct: 492  -----------LKKDKKHSKEKKGSKKDIKKDARKDTE-STDAEFDESSKTGFKTSTKIK 539

Query: 1218 FTAFGDDDEIPQELLL--GKHQLNELGSESAKIKAMGIMDKLSTDKTVKVLNILEKNIQD 1275
                G D E  + L     K +++E    SA  K  G+  K     + K     EK    
Sbjct: 540  ----GSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEK---- 591

Query: 1276 GSKLST 1281
            G K ST
Sbjct: 592  GEKAST 597



 Score = 45.8 bits (107), Expect = 6e-04
 Identities = 56/306 (18%), Positives = 127/306 (41%), Gaps = 29/306 (9%)

Query: 467 DEVELDALAEIERIERESAI---ERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRP 523
           D+ + D   + E  + ES     ER+   K+ +   K  KK+    YP+     +G  + 
Sbjct: 320 DDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKD 379

Query: 524 ASQETGSTGNGSRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQE 583
           A  ++ +    S+             +   + + + DS+S  + +E ++         + 
Sbjct: 380 ARNDSRNLKKASKN--------DDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKT 431

Query: 584 DIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETK 643
           D   S+K+  E+     + K D +  K + K+ +    +SK ++ +    K++E+   T+
Sbjct: 432 DNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKK---DSKKDDKKKDAKKNAES---TE 485

Query: 644 VETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETP 703
           +E+   ELK+++  + E K ++  I +  + +   +D + +++ +   ++ T     +T 
Sbjct: 486 MESDL-ELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTE 544

Query: 704 KQKGESRPETPKQ--KSDGHPETPKQKG---------DGRPETPKQKGESRPETPKQKNE 752
            ++   +P   K+  +SDG     K +G           +  T  +KGE         + 
Sbjct: 545 SEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKASTGRVPPSR 604

Query: 753 GRPETP 758
            +P  P
Sbjct: 605 EKPPLP 610


>gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]
          Length = 1163

 Score = 73.2 bits (178), Expect = 3e-12
 Identities = 128/630 (20%), Positives = 232/630 (36%), Gaps = 77/630 (12%)

Query: 322 KQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRVRSSDMDQQEDMISGVE 381
           K+ +Q     G+ ++    K +      S  KD  KL+       S D D ++D    + 
Sbjct: 350 KESQQSNFGTGEQKRYNPSKTSNGHQSKSMLKDDLKLS------SSEDSDGEQDCDKTMP 403

Query: 382 NSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNT 441
            S    N  P +    G  +    +        ++      +  ++   AN+     Q+ 
Sbjct: 404 RSTPGSNSEPSHHNSEGADNSRDDSSSHSGSESSSGSDSESESSSSDSEANEP---SQSA 460

Query: 442 SVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIER-----ERFSKEVQ 496
           S   + P T+  Q    +++  P              ++   S+++      + + KE +
Sbjct: 461 SPEPEPPPTNKWQLDNWLNKVNP-------------HKVSPASSVDSNIPSSQGYKKEGR 507

Query: 497 DKDKPLKKRKQDSYPQEAGGATGGNRPASQETGS-TGNGSRPALMVSIDLHQAGRVDSQA 555
           ++          S P+E   AT G    + + GS +G G + +   S    Q   V  + 
Sbjct: 508 EQGTG-NSYTDTSGPKETSSATPGRDSKTIQKGSESGRGRQKSPAQSDSTTQRRTVGKKQ 566

Query: 556 SITQDSDSIKKPEE-IKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMK 614
               +  + ++P   +K  ++ PV     D+  S+ S+   H    K    P + K E K
Sbjct: 567 PKKAEKAAAEEPRGGLKIESETPV-----DLASSMPSS--RHKAATKGSRKPNIKK-ESK 618

Query: 615 QSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQN 674
            S    AE K  ++    T  S  K    +ET T     +ES +            PK  
Sbjct: 619 SSPRPTAEKKKYKS----TSKSSQKSREIIETDTSSSDSDESESLPPSSQT-----PKYP 669

Query: 675 ENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQ-------------KSDGH 721
           E+  +  KP+  ++ +         P   K+      E   +             +  G 
Sbjct: 670 ESNRTPVKPSSVEEEDSFFRQRMFSPMEEKELLSPLSEPDDRYPLIVKIDLNLLTRIPGK 729

Query: 722 P--ETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNR-RDSGKPSTEKKPE 778
           P  ET   KG+ +    K   E++ +  ++ +       K+  DNR  +S KP TE K  
Sbjct: 730 PYKETEPPKGEKKNVPEKHTREAQKQASEKVSNKGKRKHKNEDDNRASESKKPKTEDKNS 789

Query: 779 VSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQS 838
              HK  +  +S +  + + + L   P G   S+  + +H +++++  +  S +   + +
Sbjct: 790 AG-HKPSSNRESSKQSAAKEKDLLPSPAGPVPSKDPKTEHGSRKRTISQSSSLKSSSNSN 848

Query: 839 RVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQG 898
           +    ET  SS  +     S +SK  K E K    S + +E+  S      P +P +   
Sbjct: 849 K----ETSGSSKNS-----SSTSKQKKTEGKTSSSSKEVKEKAPSSSSNCPPSAPTL--- 896

Query: 899 DSNKSRSDKLGFKSPT-SKDDKRTEGNKSK 927
           DS+K R  KL F     S D    E  K K
Sbjct: 897 DSSKPRRTKLVFDDRNYSADHYLQEAKKLK 926



 Score = 65.5 bits (158), Expect = 7e-10
 Identities = 113/608 (18%), Positives = 216/608 (35%), Gaps = 65/608 (10%)

Query: 590  KSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTE 649
            K+ P   P   K+         E K+         P++        S  K + K+ +  +
Sbjct: 339  KTEPSKFPFPTKESQQSNFGTGEQKRYN-------PSKTSNGHQSKSMLKDDLKLSSSED 391

Query: 650  ELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGES 709
               + +   T  +    +  EP  + +  +D   +D+  ++G   ++ S  E+     +S
Sbjct: 392  SDGEQDCDKTMPRSTPGSNSEPSHHNSEGADNSRDDSSSHSGSESSSGSDSESESSSSDS 451

Query: 710  RPETPKQKSDGHPETPK----------QKGDGRPETPKQKGESR-PETPKQKNEGRPETP 758
                P Q +   PE P            K +    +P    +S  P +   K EGR +  
Sbjct: 452  EANEPSQSASPEPEPPPTNKWQLDNWLNKVNPHKVSPASSVDSNIPSSQGYKKEGREQGT 511

Query: 759  KHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDH 818
             + + +       S  K+   +   +D+K+     +S R    +Q+   +S S + RR  
Sbjct: 512  GNSYTDT------SGPKETSSATPGRDSKTIQKGSESGRG---RQKSPAQSDSTTQRRTV 562

Query: 819  DNKQ-KSDDRGESERHRGD-QSRVRRPETLRSSS-RNEHGIKSDSSKTDKLERKHRHESG 875
              KQ K  ++  +E  RG  +     P  L SS   + H   +  S+   ++++ +    
Sbjct: 563  GKKQPKKAEKAAAEEPRGGLKIESETPVDLASSMPSSRHKAATKGSRKPNIKKESKSSPR 622

Query: 876  DSRERPS-SGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAH 934
             + E+       KS   S  + + D++ S SD+     P+S+  K  E N++ V      
Sbjct: 623  PTAEKKKYKSTSKSSQKSREIIETDTSSSDSDESESLPPSSQTPKYPESNRTPVK----- 677

Query: 935  PDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVED 994
            P +  E  S+                  R +  +  +E + +    EP D+   I  + D
Sbjct: 678  PSSVEEEDSFF-----------------RQRMFSPMEEKELLSPLSEPDDRYPLIVKI-D 719

Query: 995  LNK----GAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKE 1050
            LN       KP    +    +      K   +  + + + + NK  + +K   D    + 
Sbjct: 720  LNLLTRIPGKPYKETEPPKGEKKNVPEKHTREAQKQASEKVSNKGKRKHKNEDDNRASES 779

Query: 1051 LPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKD 1110
              P+   E +++            K+S   EK      +    +   +    SRKR    
Sbjct: 780  KKPK--TEDKNSAGHKPSSNRESSKQSAAKEKDLLPSPAGPVPSKDPKTEHGSRKRTISQ 837

Query: 1111 DDKAWEYEERDRRSSGDHRRSGHSH-----EGRRSSGGGRYRNRSPSDSDMEDYSPPPSL 1165
                      ++ +SG  + S  +      EG+ SS     + ++PS S     S P   
Sbjct: 838  SSSLKSSSNSNKETSGSSKNSSSTSKQKKTEGKTSSSSKEVKEKAPSSSSNCPPSAPTLD 897

Query: 1166 SEVARKMK 1173
            S   R+ K
Sbjct: 898  SSKPRRTK 905



 Score = 48.5 bits (114), Expect = 9e-05
 Identities = 124/662 (18%), Positives = 224/662 (33%), Gaps = 65/662 (9%)

Query: 602  KKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTEC 661
            +  + E    E++Q E     S P      +  S E+KL +++++      + +    + 
Sbjct: 10   RMKERERRNQEIQQGEDAFPPSSPLFAEPYKVTSKEDKLSSRIQSMLGNYDEMKDFIGD- 68

Query: 662  KQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGH 721
            +     +  PK      +D K N N        + +S   TP     S  ++ K+ S   
Sbjct: 69   RSIPKLVAIPKPTVPPSADEKSNPNFFEQRHGGSHQSSKWTPVGPAPSTSQSQKRSSGLQ 128

Query: 722  PETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEV-- 779
                 Q+      +       R +     N G     K +H +     + S+  KP+   
Sbjct: 129  SGHSSQRTSAGSSSGTNSSGQRHDRESYNNSGSSSRKKGQHGSEHSKSRSSSPGKPQAVS 188

Query: 780  ---SKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGD 836
               S H +   +D    + +R+++ +  PD    S S R    + Q S            
Sbjct: 189  SLNSSHSRSHGNDHHSKEHQRSKSPRD-PDANWDSPS-RVPFSSGQHSTQSFPPSLMSKS 246

Query: 837  QSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKH----RHESGDSRERPSSGEQKSR--- 889
             S +++P      +     +    S   KL  +H     H +  +  +PSS    ++   
Sbjct: 247  NSMLQKP------TAYVRPMDGQESMEPKLSSEHYSSQSHGNSMTELKPSSKAHLTKLKI 300

Query: 890  PDSPRVKQGDSNKSRSDKL------GFKSPTS--KDDKRTEGNKSKVDTNKAHPDN---- 937
            P  P       + S  D++       +  P +      +TE +K    T ++   N    
Sbjct: 301  PSQPLDASASGDVSCVDEILKEMTHSWPPPLTAIHTPCKTEPSKFPFPTKESQQSNFGTG 360

Query: 938  --KAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDL 995
              K   PS    G           K+   +D +  Q+  K   +  P    E        
Sbjct: 361  EQKRYNPSKTSNGHQSKSMLKDDLKLSSSEDSDGEQDCDKTMPRSTPGSNSEP---SHHN 417

Query: 996  NKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKS----------NKGSIDQ 1045
            ++GA                   D E +S SS     N+PS+S          NK  +D 
Sbjct: 418  SEGADNSRDDSSSHSGSESSSGSDSESESSSS-DSEANEPSQSASPEPEPPPTNKWQLDN 476

Query: 1046 SVLKELPPEL--LAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESS 1103
             + K  P ++   + ++S +P  +  K   R++ T N    Y + S  ++  S      S
Sbjct: 477  WLNKVNPHKVSPASSVDSNIPSSQGYKKEGREQGTGN---SYTDTSGPKETSSATPGRDS 533

Query: 1104 RKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSS--------GGGRYRNRSPSDSD 1155
            +   K  +      +   +  S   RR+    + +++         GG +  + +P D  
Sbjct: 534  KTIQKGSESGRGRQKSPAQSDSTTQRRTVGKKQPKKAEKAAAEEPRGGLKIESETPVDLA 593

Query: 1156 MEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLED 1215
                S P S  + A K  +K   KK     P+ T E+    ST K    S E I  +   
Sbjct: 594  S---SMPSSRHKAATKGSRKPNIKKESKSSPRPTAEKKKYKSTSKSSQKSREIIETDTSS 650

Query: 1216 MD 1217
             D
Sbjct: 651  SD 652



 Score = 42.7 bits (99), Expect = 0.005
 Identities = 71/396 (17%), Positives = 145/396 (36%), Gaps = 73/396 (18%)

Query: 318 SPERKQKKQKKMKLGKDEKEQSEKAAM--------------YDIISS------------- 350
           SP +     ++  +GK + +++EKAA                D+ SS             
Sbjct: 549 SPAQSDSTTQRRTVGKKQPKKAEKAAAEEPRGGLKIESETPVDLASSMPSSRHKAATKGS 608

Query: 351 -------PSKDSTKLTLRLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKT 403
                   SK S + T    + +S+    Q+       +++ S++D   ++    QT K 
Sbjct: 609 RKPNIKKESKSSPRPTAEKKKYKSTSKSSQKSREIIETDTSSSDSDESESLPPSSQTPKY 668

Query: 404 PITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQG 463
           P + +   +P +  +  S   Q  F P  +  +L   +    + P    +         G
Sbjct: 669 PESNRTPVKPSSVEEEDSFFRQRMFSPMEEKELLSPLSEPDDRYPLIVKIDLNLLTRIPG 728

Query: 464 PIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRP 523
             Y E E     +    E+ +   +++ S++V +K K   K + D+   E+       +P
Sbjct: 729 KPYKETEPPKGEKKNVPEKHTREAQKQASEKVSNKGKRKHKNEDDNRASES------KKP 782

Query: 524 ASQETGSTGNGSRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQE 583
            +++  S G+  +P+         + R  S+ S  ++ D +  P         PV     
Sbjct: 783 KTEDKNSAGH--KPS---------SNRESSKQSAAKEKDLLPSPA-------GPV----- 819

Query: 584 DIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETK 643
                    P   P+T        +S+S   +S S   +     ++   + S + K E K
Sbjct: 820 ---------PSKDPKTEHGSRKRTISQSSSLKSSSNSNKETSGSSKNSSSTSKQKKTEGK 870

Query: 644 VETQTEELKQN-ESRTTECKQNESTIVEPKQNENRL 678
             + ++E+K+   S ++ C  +  T+   K    +L
Sbjct: 871 TSSSSKEVKEKAPSSSSNCPPSAPTLDSSKPRRTKL 906



 Score = 33.9 bits (76), Expect = 2.3
 Identities = 19/70 (27%), Positives = 34/70 (48%)

Query: 2453 IDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSD 2512
            +D+  S+  S    + K S   + +KE KSSP    E    +      +KSR+ +++D+ 
Sbjct: 590  VDLASSMPSSRHKAATKGSRKPNIKKESKSSPRPTAEKKKYKSTSKSSQKSREIIETDTS 649

Query: 2513 SDSEDDINSV 2522
            S   D+  S+
Sbjct: 650  SSDSDESESL 659


>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
          Length = 2454

 Score = 72.8 bits (177), Expect = 5e-12
 Identities = 163/877 (18%), Positives = 311/877 (35%), Gaps = 114/877 (12%)

Query: 408  QDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYD 467
            +D+N    A   +++++ T      +  V+       A++ +      ++ IS+      
Sbjct: 373  EDLNSEFRAMDAVNKEKNT-----KEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLS 427

Query: 468  EVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQE 527
              ++D+    E + +    E +R +K    + K   ++++  Y          N     +
Sbjct: 428  RKQVDS----EHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEP-------ANTSEDLD 476

Query: 528  TGSTGNGSRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVG 587
                   S     +  +L  A  V  Q+S+    D     E+  + +   +++  +D  G
Sbjct: 477  MDIVSVPSSVPEDIFENLETAMEV--QSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRG 534

Query: 588  SLKS--------------TP---ENHP-------ETPKKKSDPELSKSEMKQSESRLAES 623
             +KS              TP    N P       E P+ K   +      K  +  L + 
Sbjct: 535  GIKSKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQE 594

Query: 624  KPNENRLVETKSS----ENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLS 679
              +   LVE + S    E+ L      +T  L++          ++    E  + + +LS
Sbjct: 595  NSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKLS 654

Query: 680  DTKPNDNKQNNGRSETTKSRP-ETPKQKGESRPETPKQKSDGHP------ETPKQKGDGR 732
                  +K+N+  S     +P + PK K   + ET  Q SD         E  +      
Sbjct: 655  VPVRKKDKRNSSDSAIDNPKPNKLPKSK---QSETVDQNSDSDEMLAILKEVSRMSHSSS 711

Query: 733  PETPKQKGESRPET-------PKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQD 785
             +T   +  +  +T         + ++G+ +       +  D+ K  + K   +SK K+ 
Sbjct: 712  SDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQ 771

Query: 786  TKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPET 845
            T+S+S    SE  + +K      +   + +R  + K    D  E E+H       +  + 
Sbjct: 772  TQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDF--DSSEDEKHSKKGMDNQGHKN 829

Query: 846  LRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGE---QKSRPDSPRVKQGDSNK 902
            L++S             +D  ERK   E+  S E     +    + R   P+ +Q  ++ 
Sbjct: 830  LKTSQEGS---------SDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASAST 880

Query: 903  SRSDKLGFK--SPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPK 960
               DKL  K  S TS + ++    K K    K     K +       G S   + F    
Sbjct: 881  DGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQ------DGLSDIAEKF---- 930

Query: 961  IKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDR 1020
            +K+D+    +++ KK   KG  + K        D  K    +    + S D  +KL  +R
Sbjct: 931  LKKDQSDETSEDDKKQSKKGTEEKKKPS-----DFKKKVIKMEQQYESSSDGTEKL-PER 984

Query: 1021 EDKSR--SSLKPIKNKPS----KSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKR 1074
            E+       +K IKN  +    KS K     S  K+   +   +       C+  +  K 
Sbjct: 985  EEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKS 1044

Query: 1075 KRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHS 1134
            K      + K  ++         +   S  +++   +D     ++R +R     RR+  S
Sbjct: 1045 KNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSS 1104

Query: 1135 HEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMM 1194
                +    G       S SD E+ S          K KK+    K+KA   K      +
Sbjct: 1105 KRNTKEIQSGS------SSSDAEESSED-------NKKKKQRTSSKKKAVIVKEKKRNSL 1151

Query: 1195 DSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQEL 1231
             +ST ++      +   ++ED D  + G+     Q++
Sbjct: 1152 RTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKI 1188



 Score = 72.0 bits (175), Expect = 8e-12
 Identities = 131/646 (20%), Positives = 246/646 (38%), Gaps = 111/646 (17%)

Query: 617  ESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNE---STIVEPKQ 673
            + + + S    ++L   + S   LE +   +T+E K    +T  CK+ +   S I E   
Sbjct: 873  KQQASASTDGVDKLSGKEQSFTSLEVRKVAETKE-KSKHLKTKTCKKVQDGLSDIAEKFL 931

Query: 674  NENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETP-------- 725
             +++  +T  +D KQ+   +E  K +P   K+K     +  +  SDG  + P        
Sbjct: 932  KKDQSDETSEDDKKQSKKGTEE-KKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHF 990

Query: 726  ----KQKGDGRPETPKQKGESRPETPKQKNE---------GRPETPKHRHDNRRDSGKPS 772
                KQ  +G  +  K+  + R +T K+K+E         G+ ++     D +  +G   
Sbjct: 991  PKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYG 1050

Query: 773  TEKK-----PEVSKHKQDTKSDSPRLKSERAEA------------------------LKQ 803
             EKK      + S+ +QD  S      S + +                          K+
Sbjct: 1051 REKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKE 1110

Query: 804  RPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKT 863
               G S S++     DNK+K   +  S + +    + ++  +LR+S++ +    + SS +
Sbjct: 1111 IQSGSSSSDAEESSEDNKKKK--QRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSS 1168

Query: 864  DKLERKHRHESGDSRERPSSGEQKSRPDSPRV----KQGDSNKSRSDKLGFKSPTSKDDK 919
            D +E   ++  G+     SS EQK +P +  +      G    S  + L    P + DD 
Sbjct: 1169 D-IEDDDQNSIGEG----SSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDD- 1222

Query: 920  RTEGNKSKVDTNKAHPDNK-------AEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQE 972
                     D +   P+N+        E  + L     G+  +   P+  + + G   +E
Sbjct: 1223 ---------DDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDD--EPEEGKKRTGKQNEE 1271

Query: 973  TKKMEMKGEPKDKVEKIGLVEDLNKGAKP----VVVLQKLSLDD----VQKLIKDREDKS 1024
                E   E K++V       D  +  KP     ++  KL++ D     +K  K +E K 
Sbjct: 1272 NPGDE---EAKNQVNSES-DSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKE 1327

Query: 1025 RSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPK 1084
                   K     S      +S + E   E   E        ++ ++ + +RS   +K K
Sbjct: 1328 VKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRS-YKQKKK 1386

Query: 1085 YAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGG 1144
               I   ED+ S+    S  +  +K++++  E EE +             ++  +S G G
Sbjct: 1387 RRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEED--------ENDDSKSPGKG 1438

Query: 1145 RYRNRSPSDSDMEDYSPPPSLSEVARKMKK-----KEKQKKRKAYE 1185
            R + R     D        +L E   + K+     +E++K R+  E
Sbjct: 1439 RKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIE 1484



 Score = 68.6 bits (166), Expect = 9e-11
 Identities = 199/1013 (19%), Positives = 378/1013 (37%), Gaps = 147/1013 (14%)

Query: 322  KQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRVRSSDMDQQEDMISGVE 381
            K+K  K+ K+  D K +++        +   KD +K   +LSR +       +++ +  +
Sbjct: 387  KEKNTKEHKV-IDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPTEEQ 445

Query: 382  NSNVS------ENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVP 435
             +N S      ++D     QY    +   +    ++ P +  + + +  +TA    + V 
Sbjct: 446  RTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQSSVD 505

Query: 436  VLQQNTSVAAKQPQTSVVQ-NQQQISQQGPIYDEVELDALAEIERIERESAIERERFSK- 493
                 +S   ++ ++S V+ N      +G I             + +  + + +E + K 
Sbjct: 506  HQGDGSSGTEQEVESSSVKLNISSKDNRGGI-------------KSKTTAKVTKELYVKL 552

Query: 494  -EVQDKDKPLKKRKQDSYPQEAGGATG-GNRPASQETGSTGNGSR---------PALMVS 542
              V   + P+K       PQ+  G    G  P  ++ G     S            L+  
Sbjct: 553  TPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEE 612

Query: 543  IDLHQAGRVDSQA--------SITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPE 594
             DL ++ RV +           +T +SD  +  E +K+     V V ++D   S  S  +
Sbjct: 613  SDLRRSPRVKTTPLRRPTETNPVTSNSDE-ECNETVKEKQKLSVPVRKKDKRNSSDSAID 671

Query: 595  N----------HPETPKKKSDP--------ELSK-SEMKQSESRLAESKPNENRLVETKS 635
            N            ET  + SD         E+S+ S    S++ + E   N   L + K+
Sbjct: 672  NPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKT 731

Query: 636  SENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNN----- 690
               K +     +      ++  T + K  +S+I+  K+ + +   +  +   +       
Sbjct: 732  QAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMS 791

Query: 691  --GRSETTKSRPETPKQKGESRPETPKQK---SDGHPE-TPKQKGDGRPETPKQKGE--S 742
              G + TTK R    K    S  E   +K   + GH      Q+G       KQ+ E  S
Sbjct: 792  KIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFS 851

Query: 743  RPETPKQKN----EGRPETPKHRHDNR------RDSGKPSTEKKPEVSKHKQDTKSDSPR 792
              E    K+    E R   PK +  +       + SGK  +    EV K   +TK  S  
Sbjct: 852  SAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRK-VAETKEKSKH 910

Query: 793  LKSERAEALKQRPDGRS--VSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSS 850
            LK+   +  K+  DG S    + L++D  ++   DD+ +S+  +G + + +  +  +   
Sbjct: 911  LKT---KTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSK--KGTEEKKKPSDFKKKVI 965

Query: 851  RNEHGIKSDSSKTDKLERKHR-----HESGDSRERPSSGEQKSRPDSPRVK--------- 896
            + E   +S S  T+KL  +             +   + GE+KS+    +           
Sbjct: 966  KMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDY 1025

Query: 897  ------QGDSNKSRSDKLGFKSPTSKDDKRTE--GNKSKVDTNKAHPDNKAEFPSYLLGG 948
                  +GDS  S  DK        ++ KR +  G  S+   + +  D   E  S    G
Sbjct: 1026 AEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSD--TEKYSMKEDG 1083

Query: 949  RSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNK------GAKPV 1002
             + + K     +++  ++ +  + TK+++      D  E     ED  K        K  
Sbjct: 1084 CNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEES---SEDNKKKKQRTSSKKKA 1140

Query: 1003 VVLQKLSLDDVQKLIKDRE-DKSRSSLKPIKNKPSKS-NKGSIDQSVLKELPPELLAEIE 1060
            V++++   + ++   K ++ D + SS   I++    S  +GS D+  +K +   L+  + 
Sbjct: 1141 VIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLV--LS 1198

Query: 1061 STMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEER 1120
            S    C+         S      K   ++ D+D+D ++      K+   ++ KA    + 
Sbjct: 1199 SHTGFCQ--------SSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDE 1250

Query: 1121 DRRSSGD----HRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKE 1176
            D  S  +     +R+G  +E        + +  S SDSD E+   P     + R   K  
Sbjct: 1251 DGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLR--HKLT 1308

Query: 1177 KQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQ 1229
                    E K  P+E  +     R   S E    + ED DF   G  +E+ +
Sbjct: 1309 VSDGESGEEKKTKPKEHKEVKGRNRRKVSSE----DSEDSDFQESGVSEEVSE 1357



 Score = 33.1 bits (74), Expect = 4.0
 Identities = 50/219 (22%), Positives = 84/219 (38%), Gaps = 40/219 (18%)

Query: 2460 SGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVD--SDSDSDSED 2517
            SGS+   + + S    K+K+R SS  K     + +    R    RK+ D  S S SD ED
Sbjct: 1113 SGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIED 1172

Query: 2518 DINSVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYD 2577
            D  +    + E S+   +   V++     L+L  H     GF  S              D
Sbjct: 1173 DDQN---SIGEGSSDEQKIKPVTEN----LVLSSH----TGFCQSS------------GD 1209

Query: 2578 KAINRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEG 2637
            +A+++   V        +   + +A   + EE+K ++           E    D+E EEG
Sbjct: 1210 EALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSD--------EDGSSDDEPEEG 1261

Query: 2638 EV-SASTNARNKAITSLLGGGSPKNNTAAETEDDESDGE 2675
            +  +   N  N       G    KN   +E++ D  + +
Sbjct: 1262 KKRTGKQNEENP------GDEEAKNQVNSESDSDSEESK 1294


>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
          Length = 2492

 Score = 72.8 bits (177), Expect = 5e-12
 Identities = 163/877 (18%), Positives = 311/877 (35%), Gaps = 114/877 (12%)

Query: 408  QDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYD 467
            +D+N    A   +++++ T      +  V+       A++ +      ++ IS+      
Sbjct: 411  EDLNSEFRAMDAVNKEKNT-----KEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLS 465

Query: 468  EVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQE 527
              ++D+    E + +    E +R +K    + K   ++++  Y          N     +
Sbjct: 466  RKQVDS----EHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEP-------ANTSEDLD 514

Query: 528  TGSTGNGSRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVG 587
                   S     +  +L  A  V  Q+S+    D     E+  + +   +++  +D  G
Sbjct: 515  MDIVSVPSSVPEDIFENLETAMEV--QSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRG 572

Query: 588  SLKS--------------TP---ENHP-------ETPKKKSDPELSKSEMKQSESRLAES 623
             +KS              TP    N P       E P+ K   +      K  +  L + 
Sbjct: 573  GIKSKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQE 632

Query: 624  KPNENRLVETKSS----ENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLS 679
              +   LVE + S    E+ L      +T  L++          ++    E  + + +LS
Sbjct: 633  NSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKLS 692

Query: 680  DTKPNDNKQNNGRSETTKSRP-ETPKQKGESRPETPKQKSDGHP------ETPKQKGDGR 732
                  +K+N+  S     +P + PK K   + ET  Q SD         E  +      
Sbjct: 693  VPVRKKDKRNSSDSAIDNPKPNKLPKSK---QSETVDQNSDSDEMLAILKEVSRMSHSSS 749

Query: 733  PETPKQKGESRPET-------PKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQD 785
             +T   +  +  +T         + ++G+ +       +  D+ K  + K   +SK K+ 
Sbjct: 750  SDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQ 809

Query: 786  TKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPET 845
            T+S+S    SE  + +K      +   + +R  + K    D  E E+H       +  + 
Sbjct: 810  TQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDF--DSSEDEKHSKKGMDNQGHKN 867

Query: 846  LRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGE---QKSRPDSPRVKQGDSNK 902
            L++S             +D  ERK   E+  S E     +    + R   P+ +Q  ++ 
Sbjct: 868  LKTSQEGS---------SDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASAST 918

Query: 903  SRSDKLGFK--SPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPK 960
               DKL  K  S TS + ++    K K    K     K +       G S   + F    
Sbjct: 919  DGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQ------DGLSDIAEKF---- 968

Query: 961  IKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDR 1020
            +K+D+    +++ KK   KG  + K        D  K    +    + S D  +KL  +R
Sbjct: 969  LKKDQSDETSEDDKKQSKKGTEEKKKPS-----DFKKKVIKMEQQYESSSDGTEKL-PER 1022

Query: 1021 EDKSR--SSLKPIKNKPS----KSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKR 1074
            E+       +K IKN  +    KS K     S  K+   +   +       C+  +  K 
Sbjct: 1023 EEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKS 1082

Query: 1075 KRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHS 1134
            K      + K  ++         +   S  +++   +D     ++R +R     RR+  S
Sbjct: 1083 KNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSS 1142

Query: 1135 HEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMM 1194
                +    G       S SD E+ S          K KK+    K+KA   K      +
Sbjct: 1143 KRNTKEIQSGS------SSSDAEESSED-------NKKKKQRTSSKKKAVIVKEKKRNSL 1189

Query: 1195 DSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQEL 1231
             +ST ++      +   ++ED D  + G+     Q++
Sbjct: 1190 RTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKI 1226



 Score = 72.0 bits (175), Expect = 8e-12
 Identities = 131/646 (20%), Positives = 246/646 (38%), Gaps = 111/646 (17%)

Query: 617  ESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNE---STIVEPKQ 673
            + + + S    ++L   + S   LE +   +T+E K    +T  CK+ +   S I E   
Sbjct: 911  KQQASASTDGVDKLSGKEQSFTSLEVRKVAETKE-KSKHLKTKTCKKVQDGLSDIAEKFL 969

Query: 674  NENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETP-------- 725
             +++  +T  +D KQ+   +E  K +P   K+K     +  +  SDG  + P        
Sbjct: 970  KKDQSDETSEDDKKQSKKGTEE-KKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHF 1028

Query: 726  ----KQKGDGRPETPKQKGESRPETPKQKNE---------GRPETPKHRHDNRRDSGKPS 772
                KQ  +G  +  K+  + R +T K+K+E         G+ ++     D +  +G   
Sbjct: 1029 PKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYG 1088

Query: 773  TEKK-----PEVSKHKQDTKSDSPRLKSERAEA------------------------LKQ 803
             EKK      + S+ +QD  S      S + +                          K+
Sbjct: 1089 REKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKE 1148

Query: 804  RPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKT 863
               G S S++     DNK+K   +  S + +    + ++  +LR+S++ +    + SS +
Sbjct: 1149 IQSGSSSSDAEESSEDNKKKK--QRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSS 1206

Query: 864  DKLERKHRHESGDSRERPSSGEQKSRPDSPRV----KQGDSNKSRSDKLGFKSPTSKDDK 919
            D +E   ++  G+     SS EQK +P +  +      G    S  + L    P + DD 
Sbjct: 1207 D-IEDDDQNSIGEG----SSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDD- 1260

Query: 920  RTEGNKSKVDTNKAHPDNK-------AEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQE 972
                     D +   P+N+        E  + L     G+  +   P+  + + G   +E
Sbjct: 1261 ---------DDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDD--EPEEGKKRTGKQNEE 1309

Query: 973  TKKMEMKGEPKDKVEKIGLVEDLNKGAKP----VVVLQKLSLDD----VQKLIKDREDKS 1024
                E   E K++V       D  +  KP     ++  KL++ D     +K  K +E K 
Sbjct: 1310 NPGDE---EAKNQVNSES-DSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKE 1365

Query: 1025 RSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPK 1084
                   K     S      +S + E   E   E        ++ ++ + +RS   +K K
Sbjct: 1366 VKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRS-YKQKKK 1424

Query: 1085 YAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGG 1144
               I   ED+ S+    S  +  +K++++  E EE +             ++  +S G G
Sbjct: 1425 RRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEED--------ENDDSKSPGKG 1476

Query: 1145 RYRNRSPSDSDMEDYSPPPSLSEVARKMKK-----KEKQKKRKAYE 1185
            R + R     D        +L E   + K+     +E++K R+  E
Sbjct: 1477 RKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIE 1522



 Score = 68.6 bits (166), Expect = 9e-11
 Identities = 199/1013 (19%), Positives = 378/1013 (37%), Gaps = 147/1013 (14%)

Query: 322  KQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRVRSSDMDQQEDMISGVE 381
            K+K  K+ K+  D K +++        +   KD +K   +LSR +       +++ +  +
Sbjct: 425  KEKNTKEHKV-IDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPTEEQ 483

Query: 382  NSNVS------ENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVP 435
             +N S      ++D     QY    +   +    ++ P +  + + +  +TA    + V 
Sbjct: 484  RTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQSSVD 543

Query: 436  VLQQNTSVAAKQPQTSVVQ-NQQQISQQGPIYDEVELDALAEIERIERESAIERERFSK- 493
                 +S   ++ ++S V+ N      +G I             + +  + + +E + K 
Sbjct: 544  HQGDGSSGTEQEVESSSVKLNISSKDNRGGI-------------KSKTTAKVTKELYVKL 590

Query: 494  -EVQDKDKPLKKRKQDSYPQEAGGATG-GNRPASQETGSTGNGSR---------PALMVS 542
              V   + P+K       PQ+  G    G  P  ++ G     S            L+  
Sbjct: 591  TPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEE 650

Query: 543  IDLHQAGRVDSQA--------SITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPE 594
             DL ++ RV +           +T +SD  +  E +K+     V V ++D   S  S  +
Sbjct: 651  SDLRRSPRVKTTPLRRPTETNPVTSNSDE-ECNETVKEKQKLSVPVRKKDKRNSSDSAID 709

Query: 595  N----------HPETPKKKSDP--------ELSK-SEMKQSESRLAESKPNENRLVETKS 635
            N            ET  + SD         E+S+ S    S++ + E   N   L + K+
Sbjct: 710  NPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKT 769

Query: 636  SENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNN----- 690
               K +     +      ++  T + K  +S+I+  K+ + +   +  +   +       
Sbjct: 770  QAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMS 829

Query: 691  --GRSETTKSRPETPKQKGESRPETPKQK---SDGHPE-TPKQKGDGRPETPKQKGE--S 742
              G + TTK R    K    S  E   +K   + GH      Q+G       KQ+ E  S
Sbjct: 830  KIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFS 889

Query: 743  RPETPKQKN----EGRPETPKHRHDNR------RDSGKPSTEKKPEVSKHKQDTKSDSPR 792
              E    K+    E R   PK +  +       + SGK  +    EV K   +TK  S  
Sbjct: 890  SAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRK-VAETKEKSKH 948

Query: 793  LKSERAEALKQRPDGRS--VSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSS 850
            LK+   +  K+  DG S    + L++D  ++   DD+ +S+  +G + + +  +  +   
Sbjct: 949  LKT---KTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSK--KGTEEKKKPSDFKKKVI 1003

Query: 851  RNEHGIKSDSSKTDKLERKHR-----HESGDSRERPSSGEQKSRPDSPRVK--------- 896
            + E   +S S  T+KL  +             +   + GE+KS+    +           
Sbjct: 1004 KMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDY 1063

Query: 897  ------QGDSNKSRSDKLGFKSPTSKDDKRTE--GNKSKVDTNKAHPDNKAEFPSYLLGG 948
                  +GDS  S  DK        ++ KR +  G  S+   + +  D   E  S    G
Sbjct: 1064 AEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSD--TEKYSMKEDG 1121

Query: 949  RSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNK------GAKPV 1002
             + + K     +++  ++ +  + TK+++      D  E     ED  K        K  
Sbjct: 1122 CNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEES---SEDNKKKKQRTSSKKKA 1178

Query: 1003 VVLQKLSLDDVQKLIKDRE-DKSRSSLKPIKNKPSKS-NKGSIDQSVLKELPPELLAEIE 1060
            V++++   + ++   K ++ D + SS   I++    S  +GS D+  +K +   L+  + 
Sbjct: 1179 VIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLV--LS 1236

Query: 1061 STMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEER 1120
            S    C+         S      K   ++ D+D+D ++      K+   ++ KA    + 
Sbjct: 1237 SHTGFCQ--------SSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDE 1288

Query: 1121 DRRSSGD----HRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKE 1176
            D  S  +     +R+G  +E        + +  S SDSD E+   P     + R   K  
Sbjct: 1289 DGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLR--HKLT 1346

Query: 1177 KQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQ 1229
                    E K  P+E  +     R   S E    + ED DF   G  +E+ +
Sbjct: 1347 VSDGESGEEKKTKPKEHKEVKGRNRRKVSSE----DSEDSDFQESGVSEEVSE 1395



 Score = 33.1 bits (74), Expect = 4.0
 Identities = 50/219 (22%), Positives = 84/219 (38%), Gaps = 40/219 (18%)

Query: 2460 SGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVD--SDSDSDSED 2517
            SGS+   + + S    K+K+R SS  K     + +    R    RK+ D  S S SD ED
Sbjct: 1151 SGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIED 1210

Query: 2518 DINSVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYD 2577
            D  +    + E S+   +   V++     L+L  H     GF  S              D
Sbjct: 1211 DDQN---SIGEGSSDEQKIKPVTEN----LVLSSH----TGFCQSS------------GD 1247

Query: 2578 KAINRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEG 2637
            +A+++   V        +   + +A   + EE+K ++           E    D+E EEG
Sbjct: 1248 EALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSD--------EDGSSDDEPEEG 1299

Query: 2638 EV-SASTNARNKAITSLLGGGSPKNNTAAETEDDESDGE 2675
            +  +   N  N       G    KN   +E++ D  + +
Sbjct: 1300 KKRTGKQNEENP------GDEEAKNQVNSESDSDSEESK 1332


>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
           [Homo sapiens]
          Length = 624

 Score = 72.8 bits (177), Expect = 5e-12
 Identities = 82/382 (21%), Positives = 148/382 (38%), Gaps = 62/382 (16%)

Query: 589 LKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQT 648
           LK    N+      +  P+ +  E+++   R+ E++   +  +E +S ++          
Sbjct: 251 LKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSN--------- 301

Query: 649 EELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRS-ETTKSRPETPKQKG 707
            E K   SR+    ++ S+      +  + S +K      N  RS +  + R ++P +K 
Sbjct: 302 -ERKGGRSRSHTRSKSRSS--SKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKR 358

Query: 708 ESRPETPKQKSDGHP--------ETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPK 759
               E  K +S  H         E  K+K   + +  +++ E   E  K+K  G+ +   
Sbjct: 359 SKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRD 418

Query: 760 HRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHD 819
              +  R+  K    ++    +H++D   +    K +  +  K+R   RS      ++ D
Sbjct: 419 KEREKDREKDKEKDREREREKEHEKDRDKE----KEKEQDKEKEREKDRS------KEID 468

Query: 820 NKQKSDDRG-------ESERHRGDQSRVRRPETLRSSSRNEHGIKS------------DS 860
            K+K D +         + R     SR RR    RSSSR+    K+              
Sbjct: 469 EKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSR 528

Query: 861 SKTDKLERKHRHESGDSRERPSS-----------GEQKSRPDSPRVKQGDSNKSRSDKLG 909
           +K DK   K R    + RER  S           G++K   +S  +K+ + NK     + 
Sbjct: 529 NKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVS 588

Query: 910 FKSPTSKDDKRTEGNKSKVDTN 931
            K    KD  RTE NK + + N
Sbjct: 589 -KEVDDKDAPRTEENKIQHNGN 609



 Score = 48.5 bits (114), Expect = 9e-05
 Identities = 75/383 (19%), Positives = 144/383 (37%), Gaps = 86/383 (22%)

Query: 794  KSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNE 853
            KS   +  + R   RS S S  + H  +++S  +  S  H  ++SR R+ +  RS S ++
Sbjct: 299  KSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSH--NRSRSRQKDRRRSKSPHK 356

Query: 854  HGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSP 913
               KS   +  +     R +  D+RE+    E        RVK+ D  K R  +      
Sbjct: 357  KRSKSRERRKSRSRSHSRDKRKDTREKIKEKE--------RVKEKDREKERERE------ 402

Query: 914  TSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQET 973
              + +K  E  K+K D +K    ++                       ++DK+ +  +E 
Sbjct: 403  -KEREKEKERGKNK-DRDKEREKDR-----------------------EKDKEKDRERER 437

Query: 974  KKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKN 1033
            +K   K   K+K ++    ++  K              D  K I ++  K + S  P   
Sbjct: 438  EKEHEKDRDKEKEKEQDKEKEREK--------------DRSKEIDEKRKKDKKSRTP--- 480

Query: 1034 KPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDED 1093
             P   N     +S  +E                   +  +R RS+ +  P+ ++    + 
Sbjct: 481  -PRSYNASRRSRSSSRE-------------------RRRRRSRSS-SRSPRTSKTIKRKS 519

Query: 1094 NDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSD 1153
            + S      ++K  K++ ++    E R+R  S   R+S +  +G+      +    S S 
Sbjct: 520  SRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKE-----KLEKNSTSL 574

Query: 1154 SDMEDYSPPPSLSEVARKMKKKE 1176
             + E    P   S V++++  K+
Sbjct: 575  KEKEHNKEPD--SSVSKEVDDKD 595



 Score = 43.5 bits (101), Expect = 0.003
 Identities = 41/191 (21%), Positives = 78/191 (40%), Gaps = 27/191 (14%)

Query: 1020 REDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTV 1079
            ++D+ RS     K   S+  + S  +S  ++   +   +I+    + E+ +  +R+R   
Sbjct: 345  QKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKE 404

Query: 1080 NEKPKYAEISSDEDNDSDEAFESSR---------KRHKKDDDKAWEYEERDRRSSGDHRR 1130
             EK K    + D D + ++  E  +         K H+KD DK  E +E+D+    +  R
Sbjct: 405  REKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKE-KEQDKEKEREKDR 463

Query: 1131 SGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTP 1190
            S    E R+               D +  +PP S +   R      ++++R++     +P
Sbjct: 464  SKEIDEKRK--------------KDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSP 509

Query: 1191 EEMMDSSTFKR 1201
                 S T KR
Sbjct: 510  R---TSKTIKR 517



 Score = 38.5 bits (88), Expect = 0.094
 Identities = 66/345 (19%), Positives = 121/345 (35%), Gaps = 67/345 (19%)

Query: 878  RERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDN 937
            RE  S       P+S +  +    +SRS        +SK   R + ++SK   +++   N
Sbjct: 283  REAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSK---HRSRSHN 339

Query: 938  KAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNK 997
            ++         R    +    P  KR K     +   +   + + KD  EKI   E + +
Sbjct: 340  RSR-------SRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKE 392

Query: 998  GAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLA 1057
                                KDRE +     +  K K    NK                 
Sbjct: 393  --------------------KDREKEREREKEREKEKERGKNKDR--------------- 417

Query: 1058 EIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSR-KRHKKDDDKAWE 1116
                     ++ +   R++    ++ +  E   ++D D ++  E  + K  +KD  K  +
Sbjct: 418  ---------DKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEID 468

Query: 1117 YEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARK----- 1171
             + +  + S    RS ++    RSS   R R RS S S       P +   + RK     
Sbjct: 469  EKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSS-----RSPRTSKTIKRKSSRSP 523

Query: 1172 --MKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLE 1214
                + +K KKR+     ++     + ST  R +++  +  + LE
Sbjct: 524  SPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLE 568


>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
           [Homo sapiens]
          Length = 508

 Score = 72.8 bits (177), Expect = 5e-12
 Identities = 82/382 (21%), Positives = 148/382 (38%), Gaps = 62/382 (16%)

Query: 589 LKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQT 648
           LK    N+      +  P+ +  E+++   R+ E++   +  +E +S ++          
Sbjct: 135 LKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSN--------- 185

Query: 649 EELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRS-ETTKSRPETPKQKG 707
            E K   SR+    ++ S+      +  + S +K      N  RS +  + R ++P +K 
Sbjct: 186 -ERKGGRSRSHTRSKSRSS--SKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKR 242

Query: 708 ESRPETPKQKSDGHP--------ETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPK 759
               E  K +S  H         E  K+K   + +  +++ E   E  K+K  G+ +   
Sbjct: 243 SKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRD 302

Query: 760 HRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHD 819
              +  R+  K    ++    +H++D   +    K +  +  K+R   RS      ++ D
Sbjct: 303 KEREKDREKDKEKDREREREKEHEKDRDKE----KEKEQDKEKEREKDRS------KEID 352

Query: 820 NKQKSDDRG-------ESERHRGDQSRVRRPETLRSSSRNEHGIKS------------DS 860
            K+K D +         + R     SR RR    RSSSR+    K+              
Sbjct: 353 EKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSR 412

Query: 861 SKTDKLERKHRHESGDSRERPSS-----------GEQKSRPDSPRVKQGDSNKSRSDKLG 909
           +K DK   K R    + RER  S           G++K   +S  +K+ + NK     + 
Sbjct: 413 NKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVS 472

Query: 910 FKSPTSKDDKRTEGNKSKVDTN 931
            K    KD  RTE NK + + N
Sbjct: 473 -KEVDDKDAPRTEENKIQHNGN 493



 Score = 48.5 bits (114), Expect = 9e-05
 Identities = 75/383 (19%), Positives = 144/383 (37%), Gaps = 86/383 (22%)

Query: 794  KSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNE 853
            KS   +  + R   RS S S  + H  +++S  +  S  H  ++SR R+ +  RS S ++
Sbjct: 183  KSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSH--NRSRSRQKDRRRSKSPHK 240

Query: 854  HGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSP 913
               KS   +  +     R +  D+RE+    E        RVK+ D  K R  +      
Sbjct: 241  KRSKSRERRKSRSRSHSRDKRKDTREKIKEKE--------RVKEKDREKERERE------ 286

Query: 914  TSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQET 973
              + +K  E  K+K D +K    ++                       ++DK+ +  +E 
Sbjct: 287  -KEREKEKERGKNK-DRDKEREKDR-----------------------EKDKEKDRERER 321

Query: 974  KKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKN 1033
            +K   K   K+K ++    ++  K              D  K I ++  K + S  P   
Sbjct: 322  EKEHEKDRDKEKEKEQDKEKEREK--------------DRSKEIDEKRKKDKKSRTP--- 364

Query: 1034 KPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDED 1093
             P   N     +S  +E                   +  +R RS+ +  P+ ++    + 
Sbjct: 365  -PRSYNASRRSRSSSRE-------------------RRRRRSRSS-SRSPRTSKTIKRKS 403

Query: 1094 NDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSD 1153
            + S      ++K  K++ ++    E R+R  S   R+S +  +G+      +    S S 
Sbjct: 404  SRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKE-----KLEKNSTSL 458

Query: 1154 SDMEDYSPPPSLSEVARKMKKKE 1176
             + E    P   S V++++  K+
Sbjct: 459  KEKEHNKEPD--SSVSKEVDDKD 479



 Score = 43.5 bits (101), Expect = 0.003
 Identities = 41/191 (21%), Positives = 78/191 (40%), Gaps = 27/191 (14%)

Query: 1020 REDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTV 1079
            ++D+ RS     K   S+  + S  +S  ++   +   +I+    + E+ +  +R+R   
Sbjct: 229  QKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKE 288

Query: 1080 NEKPKYAEISSDEDNDSDEAFESSR---------KRHKKDDDKAWEYEERDRRSSGDHRR 1130
             EK K    + D D + ++  E  +         K H+KD DK  E +E+D+    +  R
Sbjct: 289  REKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKE-KEQDKEKEREKDR 347

Query: 1131 SGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTP 1190
            S    E R+               D +  +PP S +   R      ++++R++     +P
Sbjct: 348  SKEIDEKRK--------------KDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSP 393

Query: 1191 EEMMDSSTFKR 1201
                 S T KR
Sbjct: 394  R---TSKTIKR 401



 Score = 38.5 bits (88), Expect = 0.094
 Identities = 66/345 (19%), Positives = 121/345 (35%), Gaps = 67/345 (19%)

Query: 878  RERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDN 937
            RE  S       P+S +  +    +SRS        +SK   R + ++SK   +++   N
Sbjct: 167  REAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSK---HRSRSHN 223

Query: 938  KAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNK 997
            ++         R    +    P  KR K     +   +   + + KD  EKI   E + +
Sbjct: 224  RSR-------SRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKE 276

Query: 998  GAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLA 1057
                                KDRE +     +  K K    NK                 
Sbjct: 277  --------------------KDREKEREREKEREKEKERGKNKDR--------------- 301

Query: 1058 EIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSR-KRHKKDDDKAWE 1116
                     ++ +   R++    ++ +  E   ++D D ++  E  + K  +KD  K  +
Sbjct: 302  ---------DKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEID 352

Query: 1117 YEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARK----- 1171
             + +  + S    RS ++    RSS   R R RS S S       P +   + RK     
Sbjct: 353  EKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSS-----RSPRTSKTIKRKSSRSP 407

Query: 1172 --MKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLE 1214
                + +K KKR+     ++     + ST  R +++  +  + LE
Sbjct: 408  SPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLE 452


>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
           sapiens]
          Length = 600

 Score = 72.4 bits (176), Expect = 6e-12
 Identities = 56/350 (16%), Positives = 141/350 (40%), Gaps = 13/350 (3%)

Query: 595 NHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQN 654
           N  +  +++++ E  +   +Q++ +    +  +      + ++ + + + E   ++ ++ 
Sbjct: 122 NRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKERER 181

Query: 655 ESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETP 714
           E    E ++ E    +  + E+R S+      ++    +ET + R    ++  + + E  
Sbjct: 182 EKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTERE 241

Query: 715 KQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTE 774
           ++K        +++ +   E  +++   R    +QK   R    K +    RD     TE
Sbjct: 242 REKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDR---ETE 298

Query: 775 KKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHR 834
           +K E  + ++  +  + + + ER E  ++R   R       ++ + K+K     + ER+R
Sbjct: 299 RKRERQRERERERERNRKRERER-ERERERERQRETERDREKERERKRKRQTEMDRERNR 357

Query: 835 ---------GDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGE 885
                     ++ R R  E  R S+R     + D  +  + ER+ + E     +R +  +
Sbjct: 358 QTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQ 417

Query: 886 QKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHP 935
           ++   D    +  +  + R  + G +    +   R  G + K  T   +P
Sbjct: 418 REREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNP 467



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 76/413 (18%), Positives = 158/413 (38%), Gaps = 27/413 (6%)

Query: 596 HPETPKKKSDPELSKSEMKQSESRLAESKPNENR-LVETKSSENKLETKVETQTEELKQN 654
           H +      +    K   ++ E R  E + +  R     K    K +   E Q +  K+ 
Sbjct: 46  HKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKER 105

Query: 655 ESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETP 714
           E +T   +  +      +Q E      +  + +   GR   T  + E  +Q+   +    
Sbjct: 106 ERQTDRERDRQREKERNRQKERE----RETEREGERGRDRQTDGQRERERQRDAEKERER 161

Query: 715 KQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTE 774
           +   +   +T + +   R E  K + E R    +++ E + E    RH  R    +   E
Sbjct: 162 QTDRERQRQTERNRQKER-EREKNRQERRERERQREKENKTE---DRHSERGRERERERE 217

Query: 775 KKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSD-----DRGE 829
            + E  + +Q  +    + K+ER E  KQ    R+      RD + +++ D     DR +
Sbjct: 218 TETETERKRQTDRERDRQRKTER-EREKQAERERASERETERDKERERERDRDRDRDRRQ 276

Query: 830 SERHR-GDQSRVRRPETLRSSSR---NEHGIKSDSSKTDKLERKHRHESGDSRERPSSGE 885
            ER R  D+ R RR E  R + R    +   + +  +  K ER+   E    R+R +  +
Sbjct: 277 KERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERD 336

Query: 886 QKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYL 945
           ++   +  R +Q + ++ R+ + G +     + +R    +    + +   + + +     
Sbjct: 337 REKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERD----- 391

Query: 946 LGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKG 998
              R    +     + ++D+DG    E ++   K    ++  + G   +  KG
Sbjct: 392 ---RDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKG 441



 Score = 65.9 bits (159), Expect = 6e-10
 Identities = 68/399 (17%), Positives = 157/399 (39%), Gaps = 23/399 (5%)

Query: 601 KKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTE 660
           ++++D E  +   K+   +    +  E      +  +   + + E Q +  K+ E +T  
Sbjct: 106 ERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDR 165

Query: 661 CKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETP-----K 715
            +Q ++     K+ E   +  +  + ++   +   T+ R     ++ E   ET      K
Sbjct: 166 ERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERK 225

Query: 716 QKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEK 775
           +++D   +  ++    R +  +++  S  ET + K   R        D R+   +  T++
Sbjct: 226 RQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDR 285

Query: 776 KPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHR- 834
           K +  + ++D +++  R +    E  ++R   R       R+ + +++++   E ER R 
Sbjct: 286 KRQ-RRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERK 344

Query: 835 ----GDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRP 890
                +  R R  +T R   R     +    + D+   + R E    R+R    E++ + 
Sbjct: 345 RKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQT 404

Query: 891 DSPRVKQGDSNKSRSDKLGFKSPTSKD-DKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGR 949
           +  R  Q ++ K R  +   +S   ++  +  E  K +    +   D +A       G +
Sbjct: 405 EKDRDGQRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQA-------GRQ 457

Query: 950 SGALKNFVIPKIKRDKDGNVTQE----TKKMEMKGEPKD 984
                 +V P  +  + G V  +    T+ +  K  P+D
Sbjct: 458 RKRSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSPED 496



 Score = 65.5 bits (158), Expect = 7e-10
 Identities = 78/427 (18%), Positives = 155/427 (36%), Gaps = 63/427 (14%)

Query: 481 ERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM 540
           ER+   E+ER  +  +++D+  +K +     +E      G R   ++T            
Sbjct: 96  ERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQT------------ 143

Query: 541 VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETP 600
                      D Q    +  D+ K+ E             Q D     ++      E  
Sbjct: 144 -----------DGQRERERQRDAEKERER------------QTDRERQRQTERNRQKERE 180

Query: 601 KKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTE 660
           ++K+  E  + E ++ +    E + +E      +  E + ET+ + QT+  +  + +T  
Sbjct: 181 REKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTER 240

Query: 661 CKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG 720
            ++ ++      + E      +  +  ++  R    K R     +K + R E  +     
Sbjct: 241 EREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDR----- 295

Query: 721 HPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVS 780
             ET +          K++ +   E  +++N  R    +   +  R        +K    
Sbjct: 296 --ETER----------KRERQRERERERERNRKRERERERERERERQRETERDREKERER 343

Query: 781 KHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRV 840
           K K+ T+ D  R +    E  +Q     +  E  R    ++Q + +R E ER   D+ R 
Sbjct: 344 KRKRQTEMDRERNRQTGREGRRQ-----AERERERERERDRQSAREREERER---DRDRD 395

Query: 841 RRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS 900
           R+ E  R + ++  G +    +    ER+   ES   RER    E++   +  R +Q D 
Sbjct: 396 RQKERERQTEKDRDGQRETEKQR---EREKDRESERGRERGREREKQKGRERDRERQTDR 452

Query: 901 NKSRSDK 907
              R  K
Sbjct: 453 QAGRQRK 459



 Score = 61.6 bits (148), Expect = 1e-08
 Identities = 85/464 (18%), Positives = 186/464 (40%), Gaps = 44/464 (9%)

Query: 731  GRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDS 790
            G  E+P+++G  +                   D   D  + + +K+ E  + K+ T+ ++
Sbjct: 32   GSQESPRRRGLGQA----------------HKDADGDDRERNRQKERERRREKRQTERET 75

Query: 791  PRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSS 850
             R +  R E  K R   R      +RD + +++     E +R R ++ R R+ E  R + 
Sbjct: 76   DRKRERRRE--KDRHRKRDRHRERQRDREKERERQTDRERDRQR-EKERNRQKERERETE 132

Query: 851  RNEHGIKSDSSKTD-KLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLG 909
            R   G +    +TD + ER+ + ++   RER +  E++ + +  R K+ +  K+R ++  
Sbjct: 133  R--EGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRE 190

Query: 910  FKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNV 969
             +    K++K  + +  +    +   + + E        R    +       K +++   
Sbjct: 191  RERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQR------KTEREREK 244

Query: 970  TQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLK 1029
              E ++   +   +DK  +     D ++  +     ++      ++  +DRE + +   +
Sbjct: 245  QAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQ 304

Query: 1030 PIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEIS 1089
              + +  + N+   ++   +E   E   E E      E+ +  KRKR T  ++ +  +  
Sbjct: 305  RERERERERNR-KRERERERERERERQRETERDR---EKERERKRKRQTEMDRERNRQTG 360

Query: 1090 SDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNR 1149
             +    ++   E  R+R   D   A E EER+R    D ++       +   G      +
Sbjct: 361  REGRRQAERERERERER---DRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQ 417

Query: 1150 SPSDSDMEDYSPPPSLSEVARKM-KKKEKQKKRKAYEPKLTPEE 1192
               + D E        SE  R+  +++EKQK R+    + T  +
Sbjct: 418  REREKDRE--------SERGRERGREREKQKGRERDRERQTDRQ 453



 Score = 60.8 bits (146), Expect = 2e-08
 Identities = 89/445 (20%), Positives = 171/445 (38%), Gaps = 64/445 (14%)

Query: 475 AEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNG 534
           AE ER ER++  ER+R ++  + K++  +K +Q+   +E        R   +E  +    
Sbjct: 155 AEKER-ERQTDRERQRQTERNRQKEREREKNRQERRERE--------RQREKENKTEDRH 205

Query: 535 SRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPE 594
           S        +       + +    ++ D  +K E                          
Sbjct: 206 SERGRERERERETETETERKRQTDRERDRQRKTER------------------------- 240

Query: 595 NHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQN 654
              E  K+      S+ E ++ + R  E   + +R    K  E + + K + +TE     
Sbjct: 241 ---EREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTE----- 292

Query: 655 ESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETP 714
             R TE K+      E ++  NR  + +    ++   + ET + R +  ++K + + E  
Sbjct: 293 RDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMD 352

Query: 715 KQKSDGHPETPKQKG-DGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPST 773
           ++++       +Q G +GR +  +++   R E  +Q    R E  + R  +R+   +  T
Sbjct: 353 RERN-------RQTGREGRRQAERERERER-ERDRQSAREREERERDRDRDRQKERERQT 404

Query: 774 EKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERH 833
           EK  +    +++T+    R K   +E  ++R  GR   +   R+ D ++++D +   +R 
Sbjct: 405 EKDRD---GQRETEKQREREKDRESERGRER--GREREKQKGRERDRERQTDRQAGRQRK 459

Query: 834 RGDQSRVRRPETLRSS------SRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQK 887
           R        P T RS       +R   GI+  SS  D      R   G   +        
Sbjct: 460 RSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSPEDPKAASTRFPWGRPAKASRGRVAG 519

Query: 888 SRPDSPRV--KQGDSNKSRSDKLGF 910
            R   PR+  K+G   + R    GF
Sbjct: 520 RRRWEPRLGEKRGQGGEGRRPSGGF 544



 Score = 59.7 bits (143), Expect = 4e-08
 Identities = 84/503 (16%), Positives = 185/503 (36%), Gaps = 51/503 (10%)

Query: 712  ETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPK------QKNEGRPETPKHR-HDN 764
            E+P+++  G        GD R    +++ E R E  +      +K E R E  +HR  D 
Sbjct: 35   ESPRRRGLGQAHKDAD-GDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDR 93

Query: 765  RRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQR---------PDGRSVSESLR 815
             R+  +   +++   +  ++D + +  R + +  E   +R          DG+   E  R
Sbjct: 94   HRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQR 153

Query: 816  RDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESG 875
                 +++  DR    +   ++ + R  E  R   R     +   +KT+    +   E  
Sbjct: 154  DAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERE 213

Query: 876  DSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHP 935
              RE  +  E+K + D  R +Q  + + R  +   +  + ++ +R +  + + D ++   
Sbjct: 214  RERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRD 273

Query: 936  DNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDL 995
              + E        R    +     + KR++     +E ++   +   +++  +     + 
Sbjct: 274  RRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRET 333

Query: 996  NKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPEL 1055
             +  +                 K+RE K +   +  + +  ++ +    Q+       E 
Sbjct: 334  ERDRE-----------------KERERKRKRQTEMDRERNRQTGREGRRQA-------ER 369

Query: 1056 LAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAW 1115
              E E         +  +R+R    ++ K  E  +++D D     E  R+R K  + +  
Sbjct: 370  ERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERG 429

Query: 1116 EYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKK 1175
                R+R       R       R++   GR R RS         +PPP  +     + + 
Sbjct: 430  RERGREREKQKGRERDRERQTDRQA---GRQRKRSTL-----YVNPPPRTARSG--VVQS 479

Query: 1176 EKQKKRKAYEPKLTPEEMMDSST 1198
            +  +  +    K +PE+   +ST
Sbjct: 480  DPNRPTRGIRWKSSPEDPKAAST 502



 Score = 58.2 bits (139), Expect = 1e-07
 Identities = 79/445 (17%), Positives = 170/445 (38%), Gaps = 52/445 (11%)

Query: 749  QKNEGRPETPKHR------HDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALK 802
            ++  G  E+P+ R       D   D  + + +K+ E  + K+ T+ ++ R +  R E  K
Sbjct: 28   RRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRRE--K 85

Query: 803  QRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSK 862
             R   R      +RD + +++     E +R R ++ R R+ E  R + R   G +    +
Sbjct: 86   DRHRKRDRHRERQRDREKERERQTDRERDRQR-EKERNRQKERERETERE--GERGRDRQ 142

Query: 863  TD-KLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRT 921
            TD + ER+ + ++   RER +  E++ + +  R K+ +  K+R ++        ++ +R 
Sbjct: 143  TDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQER------RERERQRE 196

Query: 922  EGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGE 981
            + NK    T   H +   E                      R+++     ET++      
Sbjct: 197  KENK----TEDRHSERGRE----------------------RERERETETETERKRQTDR 230

Query: 982  PKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKG 1041
             +D+  K     +  +  +     ++   D  ++  +DR+       K  + +  +  + 
Sbjct: 231  ERDRQRKTERERE-KQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQR 289

Query: 1042 SIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEA-- 1099
              ++    E   E   E E      ER +  +R+R    E+ +  E   D + + +    
Sbjct: 290  RTERDRETERKRERQRERERER---ERNRKRERERERERERERQRETERDREKERERKRK 346

Query: 1100 --FESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDME 1157
               E  R+R+++   +     ER+R    +  R        R     R R +       +
Sbjct: 347  RQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEK 406

Query: 1158 DYSPPPSLSEVARKMKKKEKQKKRK 1182
            D        +   + K +E ++ R+
Sbjct: 407  DRDGQRETEKQREREKDRESERGRE 431



 Score = 42.4 bits (98), Expect = 0.007
 Identities = 68/340 (20%), Positives = 133/340 (39%), Gaps = 27/340 (7%)

Query: 850  SRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLG 909
            SR   G   +S +   L + H+   GD RER    E++ R +  + ++    K   ++  
Sbjct: 27   SRRRPG-SQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKR--ERRR 83

Query: 910  FKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNV 969
             K    K D+  E  + +    +   D + +        R    +     + +R +D   
Sbjct: 84   EKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQT 143

Query: 970  TQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLK 1029
              + ++   +   K++  +       ++  +      +    + +K  ++R ++ R   K
Sbjct: 144  DGQRERERQRDAEKERERQT------DRERQRQTERNRQKEREREKNRQERRERERQREK 197

Query: 1030 PIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYA--E 1087
              K +   S +G       +E   E   E E+     +  +   R+R T  E+ K A  E
Sbjct: 198  ENKTEDRHSERG-------RERERERETETETERKR-QTDRERDRQRKTEREREKQAERE 249

Query: 1088 ISSDEDNDSDEAFESSRKRHKKDDDKAWEYE-----ERDRRSSGDHRRSGHSHEGRRSSG 1142
             +S+ + + D+  E  R R +  D +  E E     +R RR+  D R +    E +R   
Sbjct: 250  RASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERD-RETERKRERQRERE 308

Query: 1143 GGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRK 1182
              R RNR   + + E         E  R  ++KE+++KRK
Sbjct: 309  RERERNRK-RERERERERERERQRETERD-REKERERKRK 346


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 72.4 bits (176), Expect = 6e-12
 Identities = 111/625 (17%), Positives = 205/625 (32%), Gaps = 35/625 (5%)

Query: 552  DSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKS 611
            DS +S + DSDS     +    +D+  S    D   S  S+ ++  ++ K +SD   S S
Sbjct: 584  DSDSSDSSDSDS----SDSSNSSDSSDSSDSSDSSDSSDSS-DSKSDSSKSESDSSDSDS 638

Query: 612  EMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEP 671
            +   S+S  ++S  N +   ++ +S N  ++   + + +   +   +     ++S+    
Sbjct: 639  KSDSSDSNSSDSSDNSDSS-DSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSN 697

Query: 672  KQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDG 731
                +  SD+  +D+  ++  S +  S  ++      S        SD    +       
Sbjct: 698  SSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSD 757

Query: 732  RPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTK--SD 789
              ++      S        ++    +  +   N  DS   S       S    D+   SD
Sbjct: 758  SSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSD 817

Query: 790  SPRLKSERAEALKQRPDGRSVSESLRR-------DHDNKQKSDDRGESERHRGDQSRVRR 842
            S    S  +       D  + S+S          D D+  +SD    S+      S    
Sbjct: 818  SDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSS-NS 876

Query: 843  PETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNK 902
             ++  SS  NE    SDSS +         +S DS     S +  +  DS        N 
Sbjct: 877  SDSSDSSDSNESSNSSDSSDS---SNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNS 933

Query: 903  SRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIK 962
            + SD     S +S     ++ + S   +N +   N ++         S +  +       
Sbjct: 934  NSSD----SSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSS 989

Query: 963  RDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDRED 1022
               D + + ++       +  D  +     +  N            S D       D  D
Sbjct: 990  DSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSD------SSNSSDS-----SDSSD 1038

Query: 1023 KSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEK 1082
             S SS     +  S S+  S              ++   +    E    +    S+ +  
Sbjct: 1039 SSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSD 1098

Query: 1083 PKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSG 1142
               +  SSD  + SD +  S         D +   +  D  +S D   S  S +   SS 
Sbjct: 1099 SSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSD 1158

Query: 1143 GGRYRNRSPSDSDMEDYSPPPSLSE 1167
                 + S S SD  D S   + S+
Sbjct: 1159 SSDSSDSSDS-SDSSDSSDSSNSSD 1182



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 114/655 (17%), Positives = 202/655 (30%), Gaps = 41/655 (6%)

Query: 518  TGGNRPASQETGSTGNGSRPALMVSIDLHQAGR-VDSQASITQDSDSIKKPEEIKQCNDA 576
            + GN  A+ E+ +  +    A   S +    G   DS+ +   DSDS             
Sbjct: 471  SNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTS----------- 519

Query: 577  PVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSS 636
                   D   S  +   N+      KSD    KS+   S+S  + +  + +   ++ SS
Sbjct: 520  -------DTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSS 572

Query: 637  ENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETT 696
            ++   +  ++   +   +    +    N S   +   + +    +  +D+K ++ +SE+ 
Sbjct: 573  DSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESD 632

Query: 697  KSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPE 756
             S  ++     +S        SD    +         ++      S        ++    
Sbjct: 633  SSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDS 692

Query: 757  TPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRR 816
            +         DS   S     + S       SDS    S  +       D    S+S   
Sbjct: 693  SDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDS-SN 751

Query: 817  DHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSS----KTDKLERKHRH 872
              D+   SD    S+      S     ++  SS  N+    SDSS     +D        
Sbjct: 752  SSDSSDSSDSSNSSDSSDSSDSS-DSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSS 810

Query: 873  ESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNK 932
            +S DS +  SS    S   S      +S+ S           S    R++ + S   ++ 
Sbjct: 811  DSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDS 870

Query: 933  AHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLV 992
            +   N ++         S    +        D D + +  +          D  E     
Sbjct: 871  SDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSS 930

Query: 993  EDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELP 1052
            ++ N            S D       D  D S SS     +  S S+  S D S      
Sbjct: 931  DNSN------------SSDSSNS--SDSSDSSDSSNSSDSSNSSDSSNSS-DSSDSNSSD 975

Query: 1053 PELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDD 1112
                +    +    +    +    S+ +     +  SSD  N SD +  S         D
Sbjct: 976  SSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSD 1035

Query: 1113 KAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSE 1167
             +   +  D   S D   S +S +   SS      + S S SD  D S     S+
Sbjct: 1036 SSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDS-SDSSDSSESSDSSD 1089



 Score = 69.7 bits (169), Expect = 4e-11
 Identities = 157/926 (16%), Positives = 284/926 (30%), Gaps = 65/926 (7%)

Query: 257  DDGDSSTMRNAASFPLRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSPRDVPPDILL 316
            DD DSS  +N+ S     P+    P       K S+      S+      P D     + 
Sbjct: 289  DDHDSSIGQNSDSKEYYDPEGKEDPHNEVDGDKTSK------SEENSAGIPEDNGSQRIE 342

Query: 317  DSPERKQKKQKKMK-----------LGKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRV 365
            D+ +   ++ K+++           +GK + +  E       I  PS  +  +T  + + 
Sbjct: 343  DTQKLNHRESKRVENRITKESETHAVGKSQDKGIE-------IKGPSSGNRNITKEVGKG 395

Query: 366  RSSDMDQ-QEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQE 424
                 D+ Q  MI G    NV       N++ PGQ S+       +      +   S   
Sbjct: 396  NEGKEDKGQHGMILG--KGNVKTQGEVVNIEGPGQKSEPG---NKVGHSNTGSDSNSDGY 450

Query: 425  QTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPI-YDEVELDALAEIERIERE 483
             +       +     N+S  +     +  ++    S +G   Y+  E           ++
Sbjct: 451  DSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDE----------SKD 500

Query: 484  SAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSI 543
            +    +    E  D D        DS     G    GN    +     G         S 
Sbjct: 501  NGNGSDSKGAEDDDSDSTSDTNNSDSN----GNGNNGNDDNDKSDSGKGKSDSSDSDSSD 556

Query: 544  DLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKK 603
              + +   DS  S + DS+S    +     +         D   S  S+  +        
Sbjct: 557  SSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDS 616

Query: 604  SDPELSKSEMKQSES--RLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTEC 661
            SD   SKS+  +SES    ++SK + +    + SS+N       + + +   + + +   
Sbjct: 617  SDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDN-------SDSSDSSNSSNSSDSS 669

Query: 662  KQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGH 721
              ++S+      + +  SD+  + +  N+  S  +    ++          +    SD  
Sbjct: 670  DSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSS 729

Query: 722  PETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSK 781
              +         ++      S        ++    +      +  DS   S       S 
Sbjct: 730  NSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSS 789

Query: 782  HKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVR 841
            +  D+   S    S  +       D      S   D  N   S D   S     D S   
Sbjct: 790  NSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSS-DSSDSSDSS 848

Query: 842  RPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSN 901
                  SS+R++    SDSS  D  +  +  +S DS +   S       DS      DS+
Sbjct: 849  DGSDSDSSNRSDSSNSSDSS--DSSDSSNSSDSSDSSDSNESSNSSDSSDSS--NSSDSD 904

Query: 902  KSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKI 961
             S S      S +S     +E + S  ++N +   N ++         S    N      
Sbjct: 905  SSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSN 964

Query: 962  KRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDRE 1021
              D   + + ++       +  D  +     +  +            S D          
Sbjct: 965  SSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNS 1024

Query: 1022 DKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNE 1081
              S +S     +  S  +  S D S   +      +    +    +    +    S+ + 
Sbjct: 1025 SDSSNSSDSSDSSDSSDSSDSSDSSDSSD-----SSNSSDSSDSSDSSDSSDSSDSSDSS 1079

Query: 1082 KPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSS 1141
                +  SSD  N SD +  S         D +   +  D  +S D   S  S +   SS
Sbjct: 1080 DSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSS 1139

Query: 1142 GGGRYRNRSPSDSDMEDYSPPPSLSE 1167
                  + S S SD  D S     S+
Sbjct: 1140 NSSDSSDSSES-SDSSDSSDSSDSSD 1164



 Score = 65.1 bits (157), Expect = 9e-10
 Identities = 136/805 (16%), Positives = 255/805 (31%), Gaps = 60/805 (7%)

Query: 129  SQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAPQSPAGYMP 188
            S +    S +S +    + + S SS      +S  N      +S   S  +  S +    
Sbjct: 540  SDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSS 599

Query: 189  YSHPSSYTTHPQ-MQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDY 247
             S  SS ++       +S SS   +   ++  D+  S   S +S ++ +D+  +  S D 
Sbjct: 600  NSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDS 659

Query: 248  LHMVHRLSSDDGDSSTMRNAASFPLRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSP 307
             +  +  SSD  DSS   +++S    S     S +        S       S     S  
Sbjct: 660  SNSSN--SSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSS--DSSDSDSSDS 715

Query: 308  RDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRVRS 367
             D       DS               D  + S+ +   D  SS S DS+          S
Sbjct: 716  SDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSD--SSDSSDSSN---------S 764

Query: 368  SDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTA 427
            SD     D     ++SN S+++   N      +S +     D +   +++      +  +
Sbjct: 765  SDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNS----SDSSNSSDSSDSSDSSDSDS 820

Query: 428  FLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIE 487
                        N+S ++    +S   N    S      D  + D+              
Sbjct: 821  -----------SNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSS------------N 857

Query: 488  RERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQ 547
            R   S      D        DS        +  +  +S  + S+ + S  +   S     
Sbjct: 858  RSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDS--- 914

Query: 548  AGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPE 607
                 S +S + DS       +    +D+  S    D   S  S+  ++       SD  
Sbjct: 915  -----SDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSS 969

Query: 608  LSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNEST 667
             S S      S  ++S  + +    + SS++   +   + + +   + + +     ++S+
Sbjct: 970  DSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSS-NSSDSSDSSDSSDSSNSSDSSNSSDSS 1028

Query: 668  IVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQ 727
                  + +  SD+  + +  ++  S  +    ++      S        SD    +   
Sbjct: 1029 NSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSS 1088

Query: 728  KGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTK 787
                  ++      S        ++    +      +  DS   S       S    D+ 
Sbjct: 1089 DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSS 1148

Query: 788  SDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLR 847
              S    S  +       D    S+S   D  N   S D  +S             ++  
Sbjct: 1149 ESSDSSDSSDSSDSSDSSDSSDSSDS--SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSD 1206

Query: 848  SSSRNEHGIKSDSS-KTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSD 906
            SS  ++    SDSS  +D  +    +ES DS +   S +  +  DS      DS+ S SD
Sbjct: 1207 SSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSS--DSSDSSDSTSD 1264

Query: 907  KLGFKSPTSKDDKRTEGNKSKVDTN 931
                   +    K   GN +  D++
Sbjct: 1265 S---NDESDSQSKSGNGNNNGSDSD 1286



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 121/725 (16%), Positives = 238/725 (32%), Gaps = 37/725 (5%)

Query: 220  DNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASFPLRSPQPVC 279
            DN  S    G S +  +D+    +S D        SSD  DS +  + +S    S     
Sbjct: 536  DNDKSDSGKGKSDSSDSDSSDSSNSSD--------SSDSSDSDSSDSNSSSDSDSSDSDS 587

Query: 280  SPAGSEGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQS 339
            S +    +   S       S S   S   D       DS + K    K      D   +S
Sbjct: 588  SDSSDSDSSDSSN-----SSDSSDSSDSSDSSDSS--DSSDSKSDSSKSESDSSDSDSKS 640

Query: 340  EKAAMYDIISSPSKDSTKLTLRLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQ 399
            + +      SS + DS+  +   +   SSD     D  S  ++SN S++    +     +
Sbjct: 641  DSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSE 700

Query: 400  TS-KTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQ 458
            +S  +  +  D +   +++   S    ++    +       ++S ++    +S   +   
Sbjct: 701  SSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSD 760

Query: 459  ISQQGPIYDEVEL----DALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEA 514
             S      D  +     D+    +  +  ++ +    S      +        DS   ++
Sbjct: 761  SSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDS 820

Query: 515  GGATGGNRPASQETGSTGNGSRPALMVS--IDLHQAGRVDSQ-ASITQDSDSIKKPEEIK 571
              ++  +  +     S  + S  +   S   D   + R DS  +S + DS       +  
Sbjct: 821  SNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSS 880

Query: 572  QCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLV 631
              +D+  S    D   S  S+  +  ++    SD   S +    SES  + S  N N   
Sbjct: 881  DSSDSNESSNSSDSSDSSNSSDSDSSDS-SNSSDSSDSSNSSDSSES--SNSSDNSNSSD 937

Query: 632  ETKSSENKLETKVETQTEELKQNES-RTTECKQNESTIVEPKQNENRLSDTKPNDNKQNN 690
             + SS++   +     ++    ++S  +++   + S+      N +  SD+  + +  ++
Sbjct: 938  SSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDS 997

Query: 691  GRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQK 750
              S  +    ++      S        SD    +         ++      S        
Sbjct: 998  SDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNS 1057

Query: 751  NEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSV 810
            ++    +      +  DS   S       S    D+   S    S  +       D    
Sbjct: 1058 SDSSDSSDSSDSSDSSDSSDSSD------SSESSDSSDSSNSSDSSDSSDSSDSSDSSDS 1111

Query: 811  SESL-RRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSS-KTDKLER 868
            S+S    D  N   S D  +S       +     ++  SS  ++    SDSS  +D  + 
Sbjct: 1112 SDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDS 1171

Query: 869  KHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKV 928
                +S +S +   S +     DS      DS+ S        S  S D   +  +    
Sbjct: 1172 SDSSDSSNSSDSSDSSDSSDSSDSS--DSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1229

Query: 929  DTNKA 933
            D+N++
Sbjct: 1230 DSNES 1234



 Score = 50.8 bits (120), Expect = 2e-05
 Identities = 112/540 (20%), Positives = 183/540 (33%), Gaps = 61/540 (11%)

Query: 664  NESTIVEPK-QNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHP 722
            NE  I+E   +NE   S+  P  N + NG  E  +  P T +  G          SDG P
Sbjct: 195  NEDEIIENSCRNEGNTSEITPQINSKRNGTKE-AEVTPGTGEDAG-------LDNSDGSP 246

Query: 723  -----ETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKP 777
                 +  + +G G  E  +           +  EG+    +  HD+       S E   
Sbjct: 247  SGNGADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSSIGQNSDSKEYYD 306

Query: 778  EVSKH--KQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDR--GESERH 833
               K     +   D      E +  + +    + + ++ + +H   ++ ++R   ESE H
Sbjct: 307  PEGKEDPHNEVDGDKTSKSEENSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKESETH 366

Query: 834  RGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRH----------ESGDSRERPSS 883
               +S+ +  E    SS N +  K      +  E K +H            G+       
Sbjct: 367  AVGKSQDKGIEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGP 426

Query: 884  GEQKSRPDSPRVKQGDSNK-SRSDKLGFKS------------PTSKDDKRTEGNKSKVDT 930
            G QKS P +   K G SN  S S+  G+ S            P S D+     + +    
Sbjct: 427  G-QKSEPGN---KVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESD 482

Query: 931  NKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKG---EPKDKVE 987
            N +     A + S      S    N    K   D D + T +T   +  G      D  +
Sbjct: 483  NNSSSRGDASYNS----DESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDND 538

Query: 988  KIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPS--KSNKGSIDQ 1045
            K    +  +  +         S D       D  D + SS     +  S   S+  S D 
Sbjct: 539  KSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDS 598

Query: 1046 SVLKELPPELLAEIESTMPLCERVKMNKRK----RSTVNEKPKYAEISSDEDNDSDEAFE 1101
            S   +      +   S        K +  K     S  + K   ++ +S + +D+ ++ +
Sbjct: 599  SNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSD 658

Query: 1102 SSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRS-PSDSDMEDYS 1160
            SS   +  D   +   +  D  SS D   S  S +   SS      + S  SDSD  D S
Sbjct: 659  SSNSSNSSDSSDS--SDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSS 716



 Score = 43.5 bits (101), Expect = 0.003
 Identities = 102/698 (14%), Positives = 206/698 (29%), Gaps = 22/698 (3%)

Query: 129  SQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAPQSPAGYMP 188
            S  S   S  S +   ++ S+S  S      + S N      +S         S +    
Sbjct: 626  SSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSN 685

Query: 189  YSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYL 248
             S  S  +      ++S SS        +  D+  S     +S+N    +    SS+   
Sbjct: 686  SSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSD 745

Query: 249  HMVHRLSSDDGDSSTMRNAASFPLRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSPR 308
                  SSD  DSS   N++     S     S + +      S         S    S  
Sbjct: 746  SSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSN 805

Query: 309  DVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRVRSS 368
                    DS +             D  + S  +   D   S     +  + R     SS
Sbjct: 806  SSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSS 865

Query: 369  DMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAF 428
            D     D  +  ++S+ S+++   N      +S +  +  D +   N++           
Sbjct: 866  DSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNS--SDSDSSDSSNSSDSSDSS----- 918

Query: 429  LPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIER 488
                       N+S +++   +S   N    S      D  +    ++       S    
Sbjct: 919  -----------NSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSS---N 964

Query: 489  ERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQA 548
               S +    D        DS        +  +  +S  + S+ +        S D   +
Sbjct: 965  SSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNS 1024

Query: 549  GRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPEL 608
                + +  +  SDS    +     + +  S   +    S  S   +  ++       E 
Sbjct: 1025 SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSES 1084

Query: 609  SKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTI 668
            S S    + S  ++S  + +    + SS++   +     ++    ++S  +    N S  
Sbjct: 1085 SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDS 1144

Query: 669  VEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQK 728
             +  ++ +    +  +D+  ++  S+++ S  ++      S        SD    +    
Sbjct: 1145 SDSSESSDSSDSSDSSDSSDSSDSSDSSDSS-DSSNSSDSSDSSDSSDSSDSSDSSDSSD 1203

Query: 729  GDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKS 788
                 ++      S        ++           +  DS   S       S    D+ S
Sbjct: 1204 SSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTS 1263

Query: 789  DSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDD 826
            DS      ++++     +G            N   SDD
Sbjct: 1264 DSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHSTSDD 1301



 Score = 40.8 bits (94), Expect = 0.019
 Identities = 52/249 (20%), Positives = 88/249 (35%), Gaps = 18/249 (7%)

Query: 2458 SVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSED 2517
            S S S+   S   S   D      SS S ++ +S    + S    S    DS   SDS D
Sbjct: 719  SNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSD 778

Query: 2518 DINSVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYD 2577
              NS       NS+   + +N S              N    SDS     S S+S+   D
Sbjct: 779  SSNSSDSNDSSNSSDSSDSSNSSDS-----------SNSSDSSDS--SDSSDSDSSNSSD 825

Query: 2578 KAINRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEG 2637
             + +  +    +   + D   SD ++   ++   RS      D     +  D     +  
Sbjct: 826  SSNSSDSSDSSNSSDSSD--SSDSSDGSDSDSSNRSDSSNSSDSS---DSSDSSNSSDSS 880

Query: 2638 EVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGSLRRSKRNSDSTEL 2697
            + S S  + N + +S     S  +++ +    D SD  +    +  S      NS  +  
Sbjct: 881  DSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSN 940

Query: 2698 AAQMNESVD 2706
            ++  ++S D
Sbjct: 941  SSDSSDSSD 949



 Score = 39.3 bits (90), Expect = 0.055
 Identities = 54/251 (21%), Positives = 93/251 (37%), Gaps = 25/251 (9%)

Query: 2460 SGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDI 2519
            S S    S  ES   D   +  SS S  ++SSD+ +  S    S    DS   SDS D  
Sbjct: 620  SDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDS-SDSSNSSNSSDSSDSSDSSDSS 678

Query: 2520 NSVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKA 2579
            +S       +S+   + +N S+             +    SDS     S S ++   D  
Sbjct: 679  SSSDSSNSSDSSDSSDSSNSSES-----------SDSSDSSDSDSSDSSDSSNSNSSDSD 727

Query: 2580 INRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEGEV 2639
             +  +        +     SD +NS  + +   S               D  +  +  + 
Sbjct: 728  SSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDS-----------SNSSDSSDSSDSSDS 776

Query: 2640 SASTNARNKAITSLLGGGSPKNNTA-AETEDDESDGEDRGGGTSGSLRRSKRNSDSTELA 2698
            S S+N+ +   +S     S  +N++ +    D SD  D     S +   S  +SDS++ +
Sbjct: 777  SDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSD-S 835

Query: 2699 AQMNESVDVMD 2709
            +  ++S D  D
Sbjct: 836  SNSSDSSDSSD 846



 Score = 36.2 bits (82), Expect = 0.47
 Identities = 58/264 (21%), Positives = 91/264 (34%), Gaps = 14/264 (5%)

Query: 2454 DITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDS 2513
            D + S   SN   S   S   D      S  S  ++SSDS         S     SDSDS
Sbjct: 796  DSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDS 855

Query: 2514 ----------DSEDDINSVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSK 2563
                      DS D  +S       +S+   E +N S              +    SDS 
Sbjct: 856  SNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSS 915

Query: 2564 IQKYS--PSESAKVYDKAINRKTGVHFHPKQTLDFLR-SDMANSKITEEVKRSIVKQYLD 2620
                S   SES+   D + +  +        + D    SD +NS  +     S      D
Sbjct: 916  DSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSD 975

Query: 2621 FKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGG 2680
                    D  +  +  + S S+++ N + +S     S  +N++  +   +S        
Sbjct: 976  SSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSD 1035

Query: 2681 TSGSLRRSKRNSDSTELAAQMNES 2704
            +S S   S  +SDS++ +   N S
Sbjct: 1036 SSDS-SDSSDSSDSSDSSDSSNSS 1058



 Score = 36.2 bits (82), Expect = 0.47
 Identities = 52/251 (20%), Positives = 89/251 (35%), Gaps = 22/251 (8%)

Query: 2454 DITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDS 2513
            D + S   SN   S   S   D      SS S ++  S    + S    S    DS   S
Sbjct: 1047 DSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSS 1106

Query: 2514 DSEDDINSVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESA 2573
            DS D  +S       NS+   + ++ S              N    SDS       SES+
Sbjct: 1107 DSSDSSDSSDSSDSSNSSDSSDSSDSSD--------SSDSSNSSDSSDS-------SESS 1151

Query: 2574 KVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEE 2633
               D + +  +        + D   SD +NS  + +   S      D     +  D  + 
Sbjct: 1152 DSSDSSDSSDSSDSSDSSDSSD--SSDSSNSSDSSDSSDS-----SDSSDSSDSSDSSDS 1204

Query: 2634 EEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGSLRRSKRNSD 2693
             +  + S S+++ + + +S     S  N ++  ++  +S        +S S   S   SD
Sbjct: 1205 SDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSD 1264

Query: 2694 STELAAQMNES 2704
            S + +   ++S
Sbjct: 1265 SNDESDSQSKS 1275



 Score = 34.3 bits (77), Expect = 1.8
 Identities = 50/256 (19%), Positives = 88/256 (34%), Gaps = 26/256 (10%)

Query: 2454 DITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDS 2513
            D + S + SN   S   S   D      SS S ++  S      S    S    DSDS  
Sbjct: 655  DSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSD 714

Query: 2514 DSEDDINSVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESA 2573
             S+   ++       NS+   + +N S                   SDS       S S+
Sbjct: 715  SSDSSNSNSSDSDSSNSSDSSDSSNSSDS-----------------SDSS----DSSNSS 753

Query: 2574 KVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEE 2633
               D + +  +        + D   SD +NS  + +   S      D     +  +  + 
Sbjct: 754  DSSDSSDSSNSSDSSDSSDSSD--SSDSSNSSDSNDSSNS--SDSSDSSNSSDSSNSSDS 809

Query: 2634 EEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGSLRRSKRNSD 2693
             +  + S S ++ +   ++        N++ +    D SDG D           S  +SD
Sbjct: 810  SDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSD 869

Query: 2694 STELAAQMNESVDVMD 2709
            S++ ++  ++S D  D
Sbjct: 870  SSD-SSNSSDSSDSSD 884



 Score = 33.9 bits (76), Expect = 2.3
 Identities = 44/229 (19%), Positives = 86/229 (37%), Gaps = 17/229 (7%)

Query: 2482 SSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINSVMKCLPENSAPLIEFANVSQ 2541
            S  S  ++SSDS +       S K     SDSDS+ D +        +++   + +N S 
Sbjct: 605  SDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSN 664

Query: 2542 GILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDM 2601
                         +    SDS     S S+S+   D + +  +        + D   SD 
Sbjct: 665  S-----------SDSSDSSDSS-DSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDS 712

Query: 2602 ANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKN 2661
            ++S  +     S      D     +  D     +  + S S+N+ + + +S     S  +
Sbjct: 713  SDSSDSSNSNSS----DSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSS 768

Query: 2662 NTAAETE-DDESDGEDRGGGTSGSLRRSKRNSDSTELAAQMNESVDVMD 2709
            +++  ++  D S+  D    ++ S      NS  +  ++  ++S D  D
Sbjct: 769  DSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSD 817


>gi|104526627 triadin [Homo sapiens]
          Length = 729

 Score = 72.0 bits (175), Expect = 8e-12
 Identities = 121/591 (20%), Positives = 220/591 (37%), Gaps = 75/591 (12%)

Query: 283 GSEGTPKGS--RPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSE 340
           G E T KG    PPL  +      +  ++ P   +      K+K++ K K+ + EK + +
Sbjct: 124 GDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPE-K 182

Query: 341 KAAMYDIISSPSKDSTKLTLRLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQT 400
           KA   + I    K  TK TL   + ++   ++ E+     E     +  +        + 
Sbjct: 183 KATHKEKIEKKEKPETK-TLAKEQKKAKTAEKSEEKTKK-EVKGGKQEKVKQTAAKVKEV 240

Query: 401 SKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQIS 460
            KTP  P++      AA    +Q+         + +         + P        +Q S
Sbjct: 241 QKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQAS 300

Query: 461 QQGPIYDEVELDALAEIERIERESAIERERFSKEVQD-KDKPLKKRKQDSYPQEAGGATG 519
           +  P    +E     E E+ + E  +  E   KE +D K K  K+   D   +E G A+ 
Sbjct: 301 RPTPASPALEEK---EGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKAS- 356

Query: 520 GNRPASQETGSTGNGSRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVS 579
                      T  G+     V I    A + D +    +DS   KKP E++Q       
Sbjct: 357 ----------ETKQGT-----VKIAAQAAAKKDEKK---EDSKKTKKPAEVEQPK----- 393

Query: 580 VLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENK 639
                  G  +   E H E P K    E S    KQ +++   +K     +   K+   K
Sbjct: 394 -------GKKQEKKEKHVE-PAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGK 445

Query: 640 LETKV-ETQTEELKQNESRTTECKQNESTIVEPKQNE--NRLSDTKPNDNKQNNGRSETT 696
            E K  +T  +E+++ +S  T     +   ++ K+ +    L + +P   K         
Sbjct: 446 KEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGK 505

Query: 697 KSRPETPKQKG--ESRPETPKQKSDGHP--------------ETPKQKGDGRPETPKQKG 740
           + +P+ P+ +G  E +PE P+ K +  P              +  K    G+PE    K 
Sbjct: 506 EVKPKPPQLQGKKEEKPE-PQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQ 564

Query: 741 --------ESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTE------KKPEVSKHKQDT 786
                    ++P+  K+      E P  + D  + + K ++E      KK E+S+ +   
Sbjct: 565 VKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKE 624

Query: 787 KSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQ 837
           K+D   L+ E+    K+     +V+++ +    +K   D     +   G +
Sbjct: 625 KADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTE 675



 Score = 68.9 bits (167), Expect = 7e-11
 Identities = 113/566 (19%), Positives = 217/566 (38%), Gaps = 74/566 (13%)

Query: 582  QEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESK-------PNENRLVETK 634
            +ED  G   +      E P +K +    K+E ++   R  ++K         + ++ E +
Sbjct: 119  EEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKE 178

Query: 635  SSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSE 694
              E K   K + + +E  + ++   E K+ ++     ++ +  +   K    KQ   + +
Sbjct: 179  KPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVK 238

Query: 695  TTKSRPETPKQKGESRPETPKQKSDGHPE----------------TPKQKGDGRPETPKQ 738
              +  P  PK+K E + +    K +   +                 P Q     P  P +
Sbjct: 239  EVQKTPSKPKEK-EDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTE 297

Query: 739  KGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERA 798
            +  SRP TP        E  K + + +  S     EK+    K +++T  D  + +  +A
Sbjct: 298  QA-SRP-TPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKA 355

Query: 799  EALKQRPDGRSVSESLRRDH--DNKQKSDDRGESERHRG-DQSRVRRPETLRSSSRNEHG 855
               KQ     +   + ++D   ++ +K+    E E+ +G  Q +  +      S + EH 
Sbjct: 356  SETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHS 415

Query: 856  IKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTS 915
            + SD     K ER  + E G    + +   +K    +  V+Q    + R +K G  S   
Sbjct: 416  VPSDKQVKAKTERA-KEEIGAVSIKKAVPGKKEEKTTKTVEQ----EIRKEKSGKTSSIL 470

Query: 916  KDDKRTEGNKSKVDTN--KAHPDNKAEFPSYLLGGR--------SGALKNFVIPKIKRDK 965
            KD +  +G + KV  +  +  P+ K +      G           G  +    P+IK++ 
Sbjct: 471  KDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEA 530

Query: 966  DGNVTQET----------KKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQK 1015
               ++++           +K    G+P++KV K      + K AKP             K
Sbjct: 531  KPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKP-------------K 577

Query: 1016 LIKDREDKSRS--SLKPIKNKPSKSNKGSIDQSVLKELP-PELLAEIESTMPLCERVKMN 1072
              K  E + R   S+K  K KP+      + +S  K+    E  ++ ++ M      K++
Sbjct: 578  PTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVS 637

Query: 1073 KRKRS----TVNEKPKYAEISSDEDN 1094
             RK S     V +  K A +S D ++
Sbjct: 638  TRKESLQLHNVTKAEKPARVSKDVED 663



 Score = 47.0 bits (110), Expect = 3e-04
 Identities = 74/347 (21%), Positives = 139/347 (40%), Gaps = 39/347 (11%)

Query: 873  ESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGF---KSPTSKDDKRTEGNKSKVD 929
            E  D  E    GE     D P +++ + +K +++K      K  T    K  E  K KV 
Sbjct: 120  EDDDGDEDTDKGEI----DEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKV- 174

Query: 930  TNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKI 989
              K  P+ KA     +        K     + K+ K    ++E  K E+KG  ++KV++ 
Sbjct: 175  REKEKPEKKATHKEKIEKKEKPETKTLAKEQ-KKAKTAEKSEEKTKKEVKGGKQEKVKQT 233

Query: 990  GL-VEDLNKG-AKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSN-KGSIDQS 1046
               V+++ K  +KP                K++EDK ++++   + K   +  +  ID  
Sbjct: 234  AAKVKEVQKTPSKP----------------KEKEDKEKAAVSKHEQKDQYAFCRYMIDIF 277

Query: 1047 VLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKR 1106
            V  +L P     I   +P  E+          + EK         E   +++   S  K+
Sbjct: 278  VHGDLKPGQSPAIPPPLPT-EQASRPTPASPALEEK-------EGEKKKAEKKVTSETKK 329

Query: 1107 HKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLS 1166
             +K+D K  +  E++     + +  G + E ++ +     +  +  D   ED       +
Sbjct: 330  KEKEDIK--KKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPA 387

Query: 1167 EVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNL 1213
            EV +  K K+++KK K  EP  +P++     + K+  A  E   + +
Sbjct: 388  EVEQP-KGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEI 433


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 142/913 (15%), Positives = 340/913 (37%), Gaps = 85/913 (9%)

Query: 321  RKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRVRSSDMDQQEDMISGV 380
            R+QK+Q++ +   + +EQSEK    +      +D      R       +   +E+ +   
Sbjct: 137  RRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSC 196

Query: 381  ENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQN 440
            +                 +T + P   Q   R L   +   ++E+       Q  V Q+ 
Sbjct: 197  KGH---------------ETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEE 241

Query: 441  TSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQD--- 497
                 ++ +T + + ++++ ++ P       +   ++ ++ER+  + RER  +E Q    
Sbjct: 242  EEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQE-LRRERQEEEQQQQRL 300

Query: 498  -KDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQAGRVDSQAS 556
             +++ L++++++   ++        R   QE        R        L +      +  
Sbjct: 301  RREQQLRRKQEEERREQQ-----EERREQQERREQQEERREQ-----QLRREQEERREQQ 350

Query: 557  ITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQS 616
            + ++ +  ++ +++++  +      Q      L+   +   E   ++      + ++++ 
Sbjct: 351  LRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 410

Query: 617  ESRLAESKPNENRLVETKSSENKLETKVETQTEE---LKQNESRTTECKQNESTIVEPKQ 673
            +    E +    + +  +  E + E K E +  E    ++ E R    K+ E T  E  +
Sbjct: 411  QQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEET--ERHE 468

Query: 674  NENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRP 733
             E R    K +  ++   R    K   E  +++ E R +  +++ +   E  + K     
Sbjct: 469  QERRKQQLKRDQEEER--RERWLKLEEEERREQQERREQQLRREQEERRE-QRLKRQEEE 525

Query: 734  ETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKH-----KQDTKS 788
            E  +Q+  S  +  +++ E R +  K   + R +  +     K E  +      K++ + 
Sbjct: 526  ERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEER 585

Query: 789  DSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERH----RGDQSRVRRPE 844
               RLK E+ E L+QR     V    + +   ++   +  E ER     + ++   RR +
Sbjct: 586  RQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQ 645

Query: 845  TLR--SSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQ----- 897
             LR     R E  +K +  + ++LE++ + E  + R      E++      R+K      
Sbjct: 646  QLRREQQERREQRLKREEEE-ERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKW 704

Query: 898  ----GDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGAL 953
                     +R  K+  +    +  +R +  + K    ++    + E  ++         
Sbjct: 705  QWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQR 764

Query: 954  KNFVIPKIKRDKDGNVTQ---------ETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVV 1004
            ++F       +K     Q         E ++ +++ E + + E+  L E+  K  +    
Sbjct: 765  RDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRR--- 821

Query: 1005 LQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMP 1064
             Q+   +   + +++ E   R      + +  +  +  + +   +    E   + +    
Sbjct: 822  RQRREREKELQFLEEEEQLQRRE----RAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQ 877

Query: 1065 LCERVKMNKRKRSTVNEKPKYAEISSDED---NDSDEAFESSRKRHKKDDDKAWEYEERD 1121
            L E     KR+R T+  KP   E    E     + +E  +   +  ++  ++  +Y E +
Sbjct: 878  LEEE---RKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEE 934

Query: 1122 RRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKR 1181
            +    + +      E RR     R   +       E+      L E   K +++E++KK 
Sbjct: 935  QLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEE----QLLGEEPEKRRRQEREKKY 990

Query: 1182 KAYEPKLTPEEMM 1194
            +  E     EE +
Sbjct: 991  REEEELQQEEEQL 1003



 Score = 69.7 bits (169), Expect = 4e-11
 Identities = 110/674 (16%), Positives = 268/674 (39%), Gaps = 59/674 (8%)

Query: 543  IDLHQAGRVDSQASITQD----SDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPE 598
            +D  +  R D + S+ QD     D  +     +Q  + P    ++      +   E   +
Sbjct: 95   LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ 154

Query: 599  TPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEE------LK 652
            + K++    L + + ++ +  L   +       E ++ E +L++    +TEE      L+
Sbjct: 155  SEKQE---RLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLR 211

Query: 653  QNESRTTECKQNESTIVEPKQNENRL---SDTKPNDNKQNNGRSETTKSRPETPKQKGES 709
            + E      K  E    + ++ ++R+    + K    ++   R E  K + E P+++ E 
Sbjct: 212  RRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQREL 271

Query: 710  RPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSG 769
            + E  + +     E  +++ +   E  +Q+     +  +++ E R E  + R + +    
Sbjct: 272  QEEEEQLRKLERQELRRERQE--EEQQQQRLRREQQLRRKQEEERREQQEERREQQERRE 329

Query: 770  KPSTEKKPEVSKHKQDTKSDSPRLKSE---RAEALKQRPDGRSVSESLRRDHDNKQKSDD 826
            +    ++ ++ + +++ +    R + E   R + L++  +     + LRR+   +++   
Sbjct: 330  QQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQL 389

Query: 827  RGESERHRGDQSRVRRPETLRSSS--RNEHGIKSDSSKTDKLERKHRHESG---DSRERP 881
            R E +  R  Q  +RR + LR     R E  ++ +     + E + RHE     + RE+ 
Sbjct: 390  RREQQLRREQQ--LRREQQLRREQQLRREQQLRREQQLRREQEEE-RHEQKHEQERREQR 446

Query: 882  SSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEF 941
               EQ+ R D  + ++      +  +        ++++R    K + +  +   + + + 
Sbjct: 447  LKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQ- 505

Query: 942  PSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKME--------MKGEPKDKVEKIGLVE 993
                              +++R+++    Q  K+ E        ++ E + + E+    E
Sbjct: 506  ------------------QLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERRE 547

Query: 994  DLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPP 1053
             L K  +   + Q+      Q+L +++E++    LK  + +  +  K   ++ + + L  
Sbjct: 548  QLLKREEEKRLEQERR---EQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKR 604

Query: 1054 ELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDK 1113
            E +  +E      +R+K  + +     +  K  E             +  R++  K +++
Sbjct: 605  EEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEE 664

Query: 1114 AWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMK 1173
                E+R +R   + RR     E  +     R ++R P      +       S+V  + +
Sbjct: 665  EERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPR 724

Query: 1174 KKEKQKKRKAYEPK 1187
            K+E Q++R+  E K
Sbjct: 725  KQEGQRRRQEQEEK 738



 Score = 63.5 bits (153), Expect = 3e-09
 Identities = 150/900 (16%), Positives = 344/900 (38%), Gaps = 92/900 (10%)

Query: 314  ILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRVRSSDMDQQ 373
            +  +  E++ +K++ +   ++EK Q E+      +    +   KL  +  R    + +QQ
Sbjct: 237  VFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQ 296

Query: 374  EDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQ 433
            +  +   +     + +     Q   +  +     Q+  R     Q   +QE+       +
Sbjct: 297  QQRLRREQQLRRKQEEERREQQEERREQQERREQQEERRE---QQLRREQEE------RR 347

Query: 434  VPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSK 493
               L++      ++ Q    Q +++  QQ           L   +++ RE  + RE+  +
Sbjct: 348  EQQLRREQEEERREQQLRREQEEERREQQ-----------LRREQQLRREQQLRREQQLR 396

Query: 494  EVQD--KDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQAGRV 551
              Q   +++ L++ +Q    Q+        R   +E                  H+  R 
Sbjct: 397  REQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHE-------------QKHEQERR 443

Query: 552  DSQASITQDS--DSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELS 609
            + +    Q+   D +K+ EE ++         QE     LK   E        K + E  
Sbjct: 444  EQRLKREQEERRDWLKREEETERHE-------QERRKQQLKRDQEEERRERWLKLEEEER 496

Query: 610  KSEMKQSESRLA-ESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTEC-KQNEST 667
            + + ++ E +L  E +    + ++ +  E +L+ ++ ++ +  ++ E R  +  K+ E  
Sbjct: 497  REQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEK 556

Query: 668  IVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQ 727
             +E ++ E RL   +     Q   R E  + R +  K++ E R E   ++ +      ++
Sbjct: 557  RLEQERREQRLKREQEERRDQLLKREE--ERRQQRLKREQEERLEQRLKREEVERLEQEE 614

Query: 728  KGDGRPETPKQKGESRPETPK-QKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDT 786
            + + R +  + + E R +  K ++ E R +    R    R   +   E++ E  + +   
Sbjct: 615  RREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKR 674

Query: 787  KSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGES--ERHRGDQSRVRRPE 844
            + +  R + E AE  +++   R  S   +     + ++D R      R R  + + RR E
Sbjct: 675  EHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQE 734

Query: 845  TLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS---- 900
                  R E  ++         ER HR +  + + R  + + ++   S R +Q  S    
Sbjct: 735  QEEKRRRRESELQWQEE-----ERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPP 789

Query: 901  -NKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIP 959
              + R  +L  +    ++ +     + K    +   + + E     L       +     
Sbjct: 790  LREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKEL--QFLEEEEQLQRRERAQ 847

Query: 960  KIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKG-----AKPVVVLQKLSLDDVQ 1014
            +++ ++DG + ++ ++   + + +D+  +  L E+  +      AKP   LQ+    + Q
Sbjct: 848  QLQEEEDG-LQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKP--ALQEQLRKEQQ 904

Query: 1015 KLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKR 1074
             L ++ E+  R   +  K +  +  +   ++  L++   +LL E        ER K  ++
Sbjct: 905  LLQEEEEELQREERE--KRRRQEQERQYREEEQLQQEEEQLLRE--------EREKRRRQ 954

Query: 1075 KRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHS 1134
            +R     K K       +  +     E   KR +++ +K +  EE + +   +       
Sbjct: 955  ERERQYRKDKKL-----QQKEEQLLGEEPEKRRRQEREKKYR-EEEELQQEEEQLLREER 1008

Query: 1135 HEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMM 1194
             + RR     +YR +     + E       L E   K + +E++++ +  E     EE +
Sbjct: 1009 EKRRRQEWERQYRKKDELQQEEEQL-----LREEREKRRLQERERQYREEEELQQEEEQL 1063



 Score = 63.5 bits (153), Expect = 3e-09
 Identities = 129/748 (17%), Positives = 278/748 (37%), Gaps = 103/748 (13%)

Query: 454  QNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQE 513
            + +QQ+ ++     E  L    E ER+++    E++   ++ + +++ LK+ ++    QE
Sbjct: 502  RREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQE 561

Query: 514  AGGATGGNRPASQETGSTGNGSRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQC 573
                        Q         R  L+   +  +  R+  +    +  +   K EE+++ 
Sbjct: 562  R---------REQRLKREQEERRDQLLKREEERRQQRLKREQE--ERLEQRLKREEVERL 610

Query: 574  NDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVET 633
                                E   E   K+ +PE  + +         E +  + R  + 
Sbjct: 611  EQ------------------EERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQ 652

Query: 634  KSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNE------NRLSDTKPNDNK 687
            +  E +L  K E + E L+Q   R  E ++ E  + E +Q +      +R+   +     
Sbjct: 653  ERREQRL--KREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLES 710

Query: 688  QNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESR---- 743
            + + R     SRP   KQ+G+ R +  ++K        + + + R    +Q+ E R    
Sbjct: 711  EADARQSKVYSRPR--KQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFT 768

Query: 744  --------PETPKQKNEGRPETPKHRHDNRRDSGKPSTEKK--PEVSKHKQDTKSDSPRL 793
                     E  +Q+   RP   + R    R   +   E++  PE  + +Q  +    R 
Sbjct: 769  WQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRERE 828

Query: 794  KSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQ--------SRVRRPET 845
            K  +    +++   R  ++ L+ + D  Q+  +R  S+  R DQ         R RR  T
Sbjct: 829  KELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHT 888

Query: 846  LRSSSRNEHGIKSDSSKTDKLERKHRHESGDSR-----ERPSSGEQKSRPDSPRVKQGDS 900
            L +    +  ++ +     + E + + E  + R     ER    E++ + +  ++ + + 
Sbjct: 889  LYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREER 948

Query: 901  NKSRSDKLGFKSPTSKDDKRTEGNKSKV------DTNKAHPDNKAEFPSYLLGGRSGALK 954
             K R  +   +    + DK+ +  + ++         +   + K      L       L+
Sbjct: 949  EKRRRQE---RERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLR 1005

Query: 955  NFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQ 1014
                 + KR +     Q  KK E++ E +  + +      L +  +     ++L  ++ Q
Sbjct: 1006 E---EREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQ 1062

Query: 1015 KLIKDREDKSRSSLKP---------------IKNKPSKSNKGSIDQSVLKELPPELLAEI 1059
             L ++RE + R  L+                ++ +P K  +   ++   +E   EL  E 
Sbjct: 1063 LLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREE--EELQQEE 1120

Query: 1060 ESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEE 1119
            E  +    R +  KR+R  +    +Y E    +  +     E   KR +++ ++  +Y E
Sbjct: 1121 EQLL----REEREKRRRQELER--QYREEEEVQQEEEQLLREEPEKRRRQELER--QYRE 1172

Query: 1120 RDRRSSGDHRRSGHSHEGRRSSGGGRYR 1147
             +     + +      E RR     +YR
Sbjct: 1173 EEELQQEEEQLLREEQEKRRQERERQYR 1200



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 116/749 (15%), Positives = 281/749 (37%), Gaps = 73/749 (9%)

Query: 481  ERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM 540
            E E  +  ER  + +Q++++  + R+++   QE     G  R   +         R  L 
Sbjct: 1029 EEEQLLREEREKRRLQERER--QYREEEELQQEEEQLLGEERETRR---------RQELE 1077

Query: 541  VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETP 600
                  +  + + +  + ++ +  ++ E  +QC +     LQ++    L+   E      
Sbjct: 1078 RQYRKEEELQQEEEQLLREEPEKRRRQERERQCREE--EELQQEEEQLLREEREKRRRQE 1135

Query: 601  KKKSDPELSKSEMKQSESRLAESKPNENRLVETKSS---ENKLETKVET--QTEELKQNE 655
             ++   E  + E++Q E +L   +P + R  E +     E +L+ + E   + E+ K+ +
Sbjct: 1136 LERQYRE--EEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQ 1193

Query: 656  SRTTECKQNESTIVEPKQ----NENRLSDTK-----PNDNKQNNGRSETTKSRPETPKQK 706
             R  + ++ E    + ++    +E++ SD K       +N   + +        E  +Q 
Sbjct: 1194 ERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQL 1253

Query: 707  GESRPETPKQKSD-GHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNR 765
             +S+    + + D  H    +Q+ D   E  + +   R    +++ E   +    R D +
Sbjct: 1254 EDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRK 1313

Query: 766  RDSGKPSTEKKPEVSKHKQDTKS---DSPRLKSERAEA--LKQRPDGRSVSESLRRDHDN 820
                K    ++ E  + +Q+T     +  +L  ER E    +Q  D +   E LR     
Sbjct: 1314 SQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQG 1373

Query: 821  KQKSDDRGESERHRGDQSRVRRPETLRSSSRNEH-------GIKSDSSKTDKLERKHRHE 873
            ++  ++     R   ++  ++  + LR   R +          + +  +  + ER  +  
Sbjct: 1374 RKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFR 1433

Query: 874  SGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKA 933
              + + R    E+K   +  +++Q    K R ++   +    +   R E ++  ++  + 
Sbjct: 1434 EEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQ 1493

Query: 934  HPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVE 993
                                    + + +RD+     QE +  E + +  ++ +++   +
Sbjct: 1494 ------------------------LRRQERDRKFR-EQELRSQEPERKFLEEEQQLHRQQ 1528

Query: 994  DLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPP 1053
               K  +    L++      ++  +DR+ +    L+  + +   S +    +  L+E   
Sbjct: 1529 RQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKV 1588

Query: 1054 ELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDE----DNDSDEAFESSRKRHKK 1109
                +    M   ++++  + ++    E+ +  +   DE    + +  +     R R   
Sbjct: 1589 RRQEQERKFMEDEQQLRRQEGQQQLRQERDR--KFREDEQLLQEREEQQLHRQERDRKFL 1646

Query: 1110 DDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVA 1169
            +++     +ER+++   D  R     E     G  +   R   D    +        E  
Sbjct: 1647 EEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERE 1706

Query: 1170 RKMKKKEKQKKRKAYEPKLTPEEMMDSST 1198
            RK  ++E+Q +R+  E K   EE +   T
Sbjct: 1707 RKFLQEEQQLRRQELERKFREEEQLRQET 1735



 Score = 58.2 bits (139), Expect = 1e-07
 Identities = 157/952 (16%), Positives = 369/952 (38%), Gaps = 97/952 (10%)

Query: 298  QSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTK 357
            + Q L    P +     LL S E+++++Q++++  ++++E+ E+    +      ++  +
Sbjct: 616  REQRLKREEPEEERRQQLLKSEEQEERRQQQLR--REQQERREQRLKRE------EEEER 667

Query: 358  LTLRLSRVRSSDMDQQEDMISGVEN------SNVSENDIPFNVQYPGQTSKTPITP---- 407
            L  RL R    +  +QE      E       S + +       +   + SK    P    
Sbjct: 668  LEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQE 727

Query: 408  -------QDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQIS 460
                   Q+  R    ++   Q+E+ A     Q    Q+       Q +    + +Q++S
Sbjct: 728  GQRRRQEQEEKRRRRESELQWQEEERAH--RQQQEEEQRRDFTWQWQAEEKSERGRQRLS 785

Query: 461  QQGPIYDEVELDALAEIERIERESAI-----ERERFSKEVQDKDKPL-----------KK 504
             + P+ ++ E    AE ER +RE        E+E+  ++ ++++K L           ++
Sbjct: 786  ARPPLREQRERQLRAE-ERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRE 844

Query: 505  RKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQAGRVDSQASITQDSDSI 564
            R Q    +E G      R  SQE               ++  +  R  +  +     + +
Sbjct: 845  RAQQLQEEEDGLQEDQERRRSQEQRRDQKWRW-----QLEEERKRRRHTLYAKPALQEQL 899

Query: 565  KKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESK 624
            +K +++ Q  +  +   + +     +   +   E   ++ + +L + E ++   +  E +
Sbjct: 900  RKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQ 959

Query: 625  PNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPN 684
              +++ ++ K  +   E   + + +E ++      E +Q E  ++  ++ + R  + +  
Sbjct: 960  YRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWE-- 1017

Query: 685  DNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRP 744
              +Q   + E  +   +  +++ E R    +++     E  +Q      E  +  GE R 
Sbjct: 1018 --RQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQ------EEEQLLGEERE 1069

Query: 745  ETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQR 804
               +Q+ E +    +          +   EK+    + +Q  + +   L+ E  + L++ 
Sbjct: 1070 TRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEE--ELQQEEEQLLREE 1127

Query: 805  PDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTD 864
             + R   E L R +  +++ + + E E+   ++   RR + L    R E  ++ +    +
Sbjct: 1128 REKRRRQE-LERQY--REEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEE---E 1181

Query: 865  KLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGN 924
            +L R+ + +    RER    E++ +    + +  D ++ RSD      P    +K     
Sbjct: 1182 QLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQ-RSDLKWQWEP----EKENAVR 1236

Query: 925  KSKVDTNKAHPDNKAEFPSYLLGGRSGA--LKNFVIPKIKRDKDGNVTQETKKMEMKGEP 982
             +KV       +   +     L  R     L++ +  + +RD++    QE ++ + +   
Sbjct: 1237 DNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDRE----QERRRWQQRDRH 1292

Query: 983  KDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGS 1042
              + E++   E      K      + S ++ Q L ++RE+K R      K +  +     
Sbjct: 1293 FPEEEQLEREEQ-----KEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQE 1347

Query: 1043 IDQSVL------KELPPELLAEIESTMPLCE---RVKMNKRKRSTVNEKP--KYAEISSD 1091
             ++  L      ++   E L   E      E   R++  +R+R  + E+   +  E    
Sbjct: 1348 REEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQ 1407

Query: 1092 EDNDSDEAF-ESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRS 1150
               D D  F E  ++  +++ D+ +  EE+  R     R+     +  R     ++R   
Sbjct: 1408 LRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEE 1467

Query: 1151 PSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRF 1202
                + E+        E  RK  ++E+Q +R+  + K   +E+      ++F
Sbjct: 1468 QLLQEREEQQ--LHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKF 1517



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 136/898 (15%), Positives = 342/898 (38%), Gaps = 68/898 (7%)

Query: 324  KKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRVRSSDMD--QQEDMISGVE 381
            ++Q++ +L  +E++Q E+  +      P ++  +   R  R R  ++   ++E+ +   E
Sbjct: 791  REQRERQLRAEERQQREQRFL------PEEEEKEQRRRQRREREKELQFLEEEEQLQRRE 844

Query: 382  NSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFL-PANQVPVLQQN 440
             +   + +    +Q   +  ++    +D        +   ++  T +  PA Q  + ++ 
Sbjct: 845  RAQQLQEEED-GLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQ 903

Query: 441  TSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQ-DKD 499
              +  ++ +    + +++  Q+       E     E E++ RE   +R R  +E Q  KD
Sbjct: 904  QLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKD 963

Query: 500  KPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQAGRVDSQASITQ 559
            K L+++++            G  P  +         R    +  +  Q  R + +    Q
Sbjct: 964  KKLQQKEEQLL---------GEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQ 1014

Query: 560  DSD-SIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSES 618
            + +   +K +E++Q  +    +L+E          E      +++      + E++Q E 
Sbjct: 1015 EWERQYRKKDELQQEEE---QLLRE----------EREKRRLQERERQYREEEELQQEEE 1061

Query: 619  RLAESKPNENRLVETKSSENKLETKVETQTEEL-------KQNESRTTECKQNESTIVEP 671
            +L   +    R  E +    K E +++ + E+L       ++ + R  +C++ E    E 
Sbjct: 1062 QLLGEERETRRRQELERQYRK-EEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEE 1120

Query: 672  KQ--NENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKG 729
            +Q   E R    +    +Q     E  +   +  +++ E R     ++     E  +Q+ 
Sbjct: 1121 EQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEE 1180

Query: 730  DG--RPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTK 787
            +   R E  K++ E R    +++ E + +  K R+ +         + +PE     +D K
Sbjct: 1181 EQLLREEQEKRRQE-RERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNK 1239

Query: 788  -----SDSPRLKSERAEALKQRPDGRSVSESL--RRDHDNKQKSDDRGESERHRGDQSRV 840
                  ++ + +      L+ R   + +   L  +++ D +Q+     + +RH  ++ ++
Sbjct: 1240 VYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQL 1299

Query: 841  RRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS 900
             R E   +  R+    +      ++ E K R +  D + R      + R + P  +Q   
Sbjct: 1300 EREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERD 1359

Query: 901  NKSRSDKLGFKSPTSK---DDKRTEGNKSKVDTNKAHPDNKA-EFPSYLLGGRSGALKNF 956
             K R ++L  +    K   +++R    + +    K     +  E    L   R    +  
Sbjct: 1360 RKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREE 1419

Query: 957  VIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKL 1016
                 ++++D    +E +++  +   +  +E+    + L +        ++  L + ++ 
Sbjct: 1420 EQQLSRQERDRKFREEEQQVRRQERERKFLEE---EQQLRQERHRKFREEEQLLQEREEQ 1476

Query: 1017 IKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKR 1076
               R+++ R  L+  +    +       +  L+   PE     E      +++   +R+R
Sbjct: 1477 QLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEE-----QQLHRQQRQR 1531

Query: 1077 STVNEKPKYA--EISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHS 1134
              + E+ +    E       D D  F    +  ++ +++    +ERDR+   + ++    
Sbjct: 1532 KFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQ 1591

Query: 1135 HEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEE 1192
             + R+     +   R      +          +     +++E+Q  R+  + K   EE
Sbjct: 1592 EQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEE 1649



 Score = 38.9 bits (89), Expect = 0.072
 Identities = 58/331 (17%), Positives = 136/331 (41%), Gaps = 27/331 (8%)

Query: 594  ENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQ 653
            E   +  +++ D +  + E++  E    +    E +L   +     L+ + + + +E  Q
Sbjct: 1489 EEEQQLRRQERDRKFREQELRSQEPE-RKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQ 1547

Query: 654  NESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPET 713
               +  + K  E   +  ++ E +LS       +Q   R    K R E  K +   R E 
Sbjct: 1548 QRRQDRDRKFREEEQLRQEREEQQLS-------RQERDR----KFRLEEQKVR---RQEQ 1593

Query: 714  PKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPST 773
             ++  +   +  +Q+G    +  +Q+ + +    +Q  + R E   HR +  R       
Sbjct: 1594 ERKFMEDEQQLRRQEGQ---QQLRQERDRKFREDEQLLQEREEQQLHRQERDRKF----L 1646

Query: 774  EKKPEVSKHK--QDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESE 831
            E++P++ + +  Q  + D  R   E  + L++  + +   +   R    +++   R E E
Sbjct: 1647 EEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERE 1706

Query: 832  RHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHES--GDSRERPSSGEQKSR 889
            R    + +  R + L    R E  ++ ++ + ++L R+ R+     + + RP   EQ+ R
Sbjct: 1707 RKFLQEEQQLRRQELERKFREEEQLRQETEQ-EQLRRQERYRKILEEEQLRPEREEQQLR 1765

Query: 890  PDSPRVKQGDSNKSRSDKLGFKSPTSKDDKR 920
                  K  +  + R ++   +  + + D++
Sbjct: 1766 RQERDRKFREEEQLRQEREEQQLRSQESDRK 1796


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 264/1350 (19%), Positives = 490/1350 (36%), Gaps = 232/1350 (17%)

Query: 143  QQTTISHSPSSRFV-PPQTSSGNRFMPQQNSPVPS-----PYA---PQSPAGYMPYSH-- 191
            +Q T+  SPS++   PP+  S ++  P +   VPS     P A   P+ P    P +   
Sbjct: 708  KQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLV 767

Query: 192  -PSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHM 250
              SS TT P +  + V S           + K + PL  +SA      P  G        
Sbjct: 768  SSSSATTKPDIPSSKVQSQA---------EEKTTPPLKTDSAKPSQSFPPTGEKVSPFDS 818

Query: 251  VHRLSSDDGDSSTMRNAASFPLRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSPRDV 310
               +     DS  + +         Q    P   +  PK ++  +  +  + P       
Sbjct: 819  -KAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPT 877

Query: 311  PPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMY--DIISSPSKDSTK----LTLRLSR 364
            PP     + +     Q+  K     +EQS + ++    I  +P    T     +T +L  
Sbjct: 878  PPGPRPTAGQTVPTPQQSPK----PQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFG 933

Query: 365  VRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQE 424
              +S   Q  ++IS            P +   PG   K    P   ++P  +        
Sbjct: 934  FGASIFSQASNLISTAGQPG------PHSQSGPGAPMKQAPAP---SQPPTSQGPPKSTG 984

Query: 425  QTAFLPANQVPVLQQNTSVAA-----KQPQTSVVQNQQQISQQGPIYDEVELDALAEIER 479
            Q    PA  +PV ++  + AA     K  Q   V+  +   +  PI D   L A      
Sbjct: 985  QAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTA------ 1038

Query: 480  IERESAIERERFSKEVQDKDK-PLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPA 538
             E + A+   +  K  + +   PL K + +   ++           +Q     G    P 
Sbjct: 1039 -EPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPH 1097

Query: 539  LMVSIDLHQAGRVDSQASITQDSDSIKK----------------PEEIKQCNDAPVSVL- 581
            L   I         +Q +I+     I+K                 E   Q    P  V  
Sbjct: 1098 L-TEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKL 1156

Query: 582  -----QEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSS 636
                 QE    + K   E   ET   +  P +  ++ KQ ES+L + K +  +  +    
Sbjct: 1157 VKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPE 1216

Query: 637  ENKL---ETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRS 693
            E KL   E K+ ++ ++    E + T          E K+       + P + K      
Sbjct: 1217 EKKLIPEEEKIRSEEKKPLLEEKKPTP---------EDKKLLPEAKTSAPEEQKH----- 1262

Query: 694  ETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPE-TPKQKGESRPETPKQKNE 752
            +  KS+ +  ++K E R   PK   +G  + P+ K +G P  TP+   +   +T K   E
Sbjct: 1263 DLLKSQVQIAEEKLEGRV-APKTVQEG--KQPQTKMEGLPSGTPQSLPKEDDKTTKTIKE 1319

Query: 753  GRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSER-------AEALKQRP 805
             +P+ P     ++ + GK  TEK+ + S      +  SP+  S+        + +L + P
Sbjct: 1320 -QPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIP 1378

Query: 806  -----DGRSVSESLRRDHDNKQKS--------------------------DDRGE--SER 832
                 D + + + L++D  +++ S                          D++ E  ++ 
Sbjct: 1379 SLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQP 1438

Query: 833  HRGDQSRVRRPETLRSSSRN-EHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPD 891
            H     + +  E  +S S   E  I  +  K  + ERK   +    ++ PSS + K + +
Sbjct: 1439 HEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSE 1498

Query: 892  -----SPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLL 946
                 + R +  DS +  S+     SP  +  +RT    S  D  K              
Sbjct: 1499 FVDDITTRREPYDSVEESSE--SENSPVPQRKRRTSVGSSSSDEYKQEDSQ--------- 1547

Query: 947  GGRSGALKNFV---IPKIKRDKDGN-------VTQETKKMEMKGEPKDKVEKIGLVEDLN 996
               SG  ++F+   I ++  D+D +       +  + K++    E + K E  G  +   
Sbjct: 1548 --GSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETKGKGKITA 1605

Query: 997  KGAKPVVVLQKLSLDD---VQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLK---E 1050
               + +      S+D+    +    D +D++      +K + +KS +   ++ V+     
Sbjct: 1606 GKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQES--EELVVTGGGG 1663

Query: 1051 LPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEA-FESSRKRHKK 1109
            L      E+ ST+      + +++K S   ++    E+ S  D+  D +  E S   H  
Sbjct: 1664 LRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHAS 1723

Query: 1110 D-----DDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPS 1164
                     +    + D  SS  H++ G S + R++    R+R   P    +ED S    
Sbjct: 1724 SFTPGTSPTSVSSLDEDSDSSPSHKK-GESKQQRKA----RHRPHGPLLPTIEDSSEEEE 1778

Query: 1165 LSEVARKMKKKEKQKKRKAYEPKLTPEEM---MDSSTFKRFTASIENILDNLEDMDFTAF 1221
            L E    +K++EKQ++ +  + K + ++     D    +R     +    NL  +     
Sbjct: 1779 LREEEELLKEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPI----- 1833

Query: 1222 GDDDEIPQELLLGKHQLNELGSESAKIKAMGIMD-----KLSTDKTVKVLNILEKNIQDG 1276
              +D  P E L    ++ EL   S    +  I       ++S +K ++V  +        
Sbjct: 1834 --EDASPTEELRQAAEMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVY------- 1884

Query: 1277 SKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTSPNMPKAVYIEDVIERV 1336
             KL T ++  + T+E+  + ++   ++  KSA+                    E+++ + 
Sbjct: 1885 -KLPTAVSLYSPTDEQSIMQKE-GSQKALKSAEE-----------------MYEEMMHKT 1925

Query: 1337 IQYTKFHLQNTLYPQYDPVYRLDPHGGGLL 1366
             +Y  F   N    + D V+  +P  GG+L
Sbjct: 1926 HKYKAFPAAN----ERDEVFEKEPLYGGML 1951



 Score = 45.8 bits (107), Expect = 6e-04
 Identities = 153/746 (20%), Positives = 246/746 (32%), Gaps = 102/746 (13%)

Query: 285 EGTPKGS-RPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAA 343
           +G P+G  +PPL    Q  P   P+   P      P ++    K +   + EK +S+   
Sbjct: 200 QGKPEGIIKPPL---QQQPPKPIPKQQGPG---RDPLQQDGTPKSISSQQPEKIKSQPPG 253

Query: 344 MYDIISSPSK----DSTKLTLRLSRVRSSDMDQQEDMISG--VENSNVSENDIPFN---- 393
               I  P++    D  KL L+  R  S    +Q D++ G  V+ S  S +  P      
Sbjct: 254 TGKPIQGPTQTPQTDHAKLPLQ--RDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTP 311

Query: 394 ----VQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQ 449
                Q PG     P   +   +P    + L+QQ  T      + PV    T+    QP 
Sbjct: 312 GKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTV-----KPPVQPPGTTKPPAQPL 366

Query: 450 TSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQD--KDKPLKKRKQ 507
                  QQ   + P  ++    ALA+   + +  A +        Q     KPL ++  
Sbjct: 367 GPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPG 426

Query: 508 DSYPQEAGGAT-----------------GGNRPASQETGSTGNGSRPALMVSIDLHQAG- 549
              P +A G T                 G  + ++Q+TG T   S+          Q G 
Sbjct: 427 LQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGP 486

Query: 550 ------RVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKK 603
                 +  S    +Q   S K P +  Q   A  S  Q    GS K   +         
Sbjct: 487 AKPPPQQPGSAKPPSQQPGSTKPPPQ--QPGPAKPSPQQP---GSTKPPSQQPGSAKPSA 541

Query: 604 SDPELSKSEMKQSE---SRLAESKPNENRLVETKSSENKLETKVET-----QTEEL---- 651
             P  +K   +QS    S+    KP +   V   + +   +   +T      T EL    
Sbjct: 542 QQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHV 601

Query: 652 --KQNESRTTECKQNESTIV--EPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKG 707
             K N +  TEC+    ++    P  +   + +    + +            P +P+ K 
Sbjct: 602 PEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKL 661

Query: 708 ESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKN-------EGRPETPKH 760
           ++ P T           P+Q    +   PKQ     PE  K           G P     
Sbjct: 662 KTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAK 721

Query: 761 RHDNRRDSGKPSTEKKPEV--SKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDH 818
           +        KP+  K+P V   + K     D P+    + + +K   D  S S +  +  
Sbjct: 722 QPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPK----QPKMVKPTTDLVSSSSATTKPD 777

Query: 819 DNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSR 878
               K   + E +     ++   +P    S S    G K     +  + R        S 
Sbjct: 778 IPSSKVQSQAEEKTTPPLKTDSAKP----SQSFPPTGEKVSPFDSKAIPRPASDSKIISH 833

Query: 879 ERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFK---------SPTSKDDKRTEGNKSKVD 929
             PSS E K +     V++ +  K    K+  K         SPT    + T G      
Sbjct: 834 PGPSS-ESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTP 892

Query: 930 TNKAHPDNKAEFPSYLLGGRSGALKN 955
                P  ++   S  LG  + A K+
Sbjct: 893 QQSPKPQEQSRRFSLNLGSITDAPKS 918



 Score = 41.2 bits (95), Expect = 0.015
 Identities = 100/530 (18%), Positives = 188/530 (35%), Gaps = 71/530 (13%)

Query: 284 SEGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAA 343
           ++G PKGS PP   +S S+             LDS    ++  +    G+  +    K+ 
Sbjct: 63  AQGLPKGSVPPAAAESPSMHRKQE--------LDSSHPPKQSGRPPDPGRPAQPGLSKSR 114

Query: 344 MYDIISS----PSKDSTKLTLRLSRVRSSDMDQQED-MISGVEN--------SNVSENDI 390
             D   S    P +  + ++L+ S+ R+   ++ +  M+ G  +        S+V     
Sbjct: 115 TTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFN 174

Query: 391 PFNVQYPGQ------TSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVP---VLQQN- 440
           PF++    +      T K  +  ++  +P    +   QQ+    +P  Q P    LQQ+ 
Sbjct: 175 PFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDG 234

Query: 441 --TSVAAKQPQTSVVQ-----NQQQISQQGPIYDEVELDALAEIERIERESA--IERERF 491
              S++++QP+    Q        Q   Q P  D  +L    +  R + + A  +  E  
Sbjct: 235 TPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESV 294

Query: 492 SKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQ---ETGSTGNGSRPALMVSIDLHQA 548
              +    KP  ++            T G  PA Q   E    G    PA    +    A
Sbjct: 295 KPSLPSPSKPPIQQP-----------TPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLA 343

Query: 549 GRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPEL 608
            +  +     Q   + K P +       P      +   S +  P+   + P     P  
Sbjct: 344 QQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQ 403

Query: 609 SKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTI 668
                K    ++   KP    L +    ++  +    T+T   +    +    +      
Sbjct: 404 QPGPAKPPTQQVGTPKP----LAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPG-- 457

Query: 669 VEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETP--KQKGESRPETPKQKSDGHPETPK 726
              K +  +   TKP        +    +  P  P  +Q G ++P  P Q+       P+
Sbjct: 458 ---KTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKP--PSQQPGSTKPPPQ 512

Query: 727 QKGDGRPETPKQKGESRPETPKQKNEGRP--ETPKHRHDNRRDSGKPSTE 774
           Q G  +P +P+Q G ++P + +Q    +P  + P     + + S KP ++
Sbjct: 513 QPGPAKP-SPQQPGSTKPPS-QQPGSAKPSAQQPSPAKPSAQQSTKPVSQ 560



 Score = 35.4 bits (80), Expect = 0.80
 Identities = 41/195 (21%), Positives = 80/195 (41%), Gaps = 20/195 (10%)

Query: 28   LPSPLPATTTKSLLFNARIAEEVNCLLACRDDNL-----VSQLVHSLNQVSTDHIELKDN 82
            LP+P P   +            V+    CR + +     +  +   L+ V  +  +L+  
Sbjct: 3724 LPNPPPEEISTGTQSTFSTMGTVSRRRICRTNTMARAKILQDIDRELDLVERESAKLRKK 3783

Query: 83   LGS-DDPEGDIPVLLQ----AVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSP 137
                D+ E +I   L+     +  R   + +E+  + R    G+   +  +S + + S+ 
Sbjct: 3784 QAELDEEEKEIDAKLRYLEMGINRRKEALLKEREKRERAYLQGVAEDRDYMSDSEVSSTR 3843

Query: 138  ASSNYQQ------TTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAPQSPAGYMPYSH 191
             +    Q       T   +  S+F+PPQT + ++ +P   SP  + Y   SPA  +P   
Sbjct: 3844 PTRIESQHGIERPRTAPQTEFSQFIPPQTQTESQLVP-PTSPY-TQYQYSSPA--LPTQA 3899

Query: 192  PSSYTTHPQMQQASV 206
            P+SYT     +Q ++
Sbjct: 3900 PTSYTQQSHFEQQTL 3914


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 264/1350 (19%), Positives = 490/1350 (36%), Gaps = 232/1350 (17%)

Query: 143  QQTTISHSPSSRFV-PPQTSSGNRFMPQQNSPVPS-----PYA---PQSPAGYMPYSH-- 191
            +Q T+  SPS++   PP+  S ++  P +   VPS     P A   P+ P    P +   
Sbjct: 708  KQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLV 767

Query: 192  -PSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHM 250
              SS TT P +  + V S           + K + PL  +SA      P  G        
Sbjct: 768  SSSSATTKPDIPSSKVQSQA---------EEKTTPPLKTDSAKPSQSFPPTGEKVSPFDS 818

Query: 251  VHRLSSDDGDSSTMRNAASFPLRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSPRDV 310
               +     DS  + +         Q    P   +  PK ++  +  +  + P       
Sbjct: 819  -KAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPT 877

Query: 311  PPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMY--DIISSPSKDSTK----LTLRLSR 364
            PP     + +     Q+  K     +EQS + ++    I  +P    T     +T +L  
Sbjct: 878  PPGPRPTAGQTVPTPQQSPK----PQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFG 933

Query: 365  VRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQE 424
              +S   Q  ++IS            P +   PG   K    P   ++P  +        
Sbjct: 934  FGASIFSQASNLISTAGQPG------PHSQSGPGAPMKQAPAP---SQPPTSQGPPKSTG 984

Query: 425  QTAFLPANQVPVLQQNTSVAA-----KQPQTSVVQNQQQISQQGPIYDEVELDALAEIER 479
            Q    PA  +PV ++  + AA     K  Q   V+  +   +  PI D   L A      
Sbjct: 985  QAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTA------ 1038

Query: 480  IERESAIERERFSKEVQDKDK-PLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPA 538
             E + A+   +  K  + +   PL K + +   ++           +Q     G    P 
Sbjct: 1039 -EPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPH 1097

Query: 539  LMVSIDLHQAGRVDSQASITQDSDSIKK----------------PEEIKQCNDAPVSVL- 581
            L   I         +Q +I+     I+K                 E   Q    P  V  
Sbjct: 1098 L-TEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKL 1156

Query: 582  -----QEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSS 636
                 QE    + K   E   ET   +  P +  ++ KQ ES+L + K +  +  +    
Sbjct: 1157 VKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPE 1216

Query: 637  ENKL---ETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRS 693
            E KL   E K+ ++ ++    E + T          E K+       + P + K      
Sbjct: 1217 EKKLIPEEEKIRSEEKKPLLEEKKPTP---------EDKKLLPEAKTSAPEEQKH----- 1262

Query: 694  ETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPE-TPKQKGESRPETPKQKNE 752
            +  KS+ +  ++K E R   PK   +G  + P+ K +G P  TP+   +   +T K   E
Sbjct: 1263 DLLKSQVQIAEEKLEGRV-APKTVQEG--KQPQTKMEGLPSGTPQSLPKEDDKTTKTIKE 1319

Query: 753  GRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSER-------AEALKQRP 805
             +P+ P     ++ + GK  TEK+ + S      +  SP+  S+        + +L + P
Sbjct: 1320 -QPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIP 1378

Query: 806  -----DGRSVSESLRRDHDNKQKS--------------------------DDRGE--SER 832
                 D + + + L++D  +++ S                          D++ E  ++ 
Sbjct: 1379 SLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQP 1438

Query: 833  HRGDQSRVRRPETLRSSSRN-EHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPD 891
            H     + +  E  +S S   E  I  +  K  + ERK   +    ++ PSS + K + +
Sbjct: 1439 HEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSE 1498

Query: 892  -----SPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLL 946
                 + R +  DS +  S+     SP  +  +RT    S  D  K              
Sbjct: 1499 FVDDITTRREPYDSVEESSE--SENSPVPQRKRRTSVGSSSSDEYKQEDSQ--------- 1547

Query: 947  GGRSGALKNFV---IPKIKRDKDGN-------VTQETKKMEMKGEPKDKVEKIGLVEDLN 996
               SG  ++F+   I ++  D+D +       +  + K++    E + K E  G  +   
Sbjct: 1548 --GSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETKGKGKITA 1605

Query: 997  KGAKPVVVLQKLSLDD---VQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLK---E 1050
               + +      S+D+    +    D +D++      +K + +KS +   ++ V+     
Sbjct: 1606 GKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQES--EELVVTGGGG 1663

Query: 1051 LPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEA-FESSRKRHKK 1109
            L      E+ ST+      + +++K S   ++    E+ S  D+  D +  E S   H  
Sbjct: 1664 LRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHAS 1723

Query: 1110 D-----DDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPS 1164
                     +    + D  SS  H++ G S + R++    R+R   P    +ED S    
Sbjct: 1724 SFTPGTSPTSVSSLDEDSDSSPSHKK-GESKQQRKA----RHRPHGPLLPTIEDSSEEEE 1778

Query: 1165 LSEVARKMKKKEKQKKRKAYEPKLTPEEM---MDSSTFKRFTASIENILDNLEDMDFTAF 1221
            L E    +K++EKQ++ +  + K + ++     D    +R     +    NL  +     
Sbjct: 1779 LREEEELLKEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPI----- 1833

Query: 1222 GDDDEIPQELLLGKHQLNELGSESAKIKAMGIMD-----KLSTDKTVKVLNILEKNIQDG 1276
              +D  P E L    ++ EL   S    +  I       ++S +K ++V  +        
Sbjct: 1834 --EDASPTEELRQAAEMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVY------- 1884

Query: 1277 SKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTSPNMPKAVYIEDVIERV 1336
             KL T ++  + T+E+  + ++   ++  KSA+                    E+++ + 
Sbjct: 1885 -KLPTAVSLYSPTDEQSIMQKE-GSQKALKSAEE-----------------MYEEMMHKT 1925

Query: 1337 IQYTKFHLQNTLYPQYDPVYRLDPHGGGLL 1366
             +Y  F   N    + D V+  +P  GG+L
Sbjct: 1926 HKYKAFPAAN----ERDEVFEKEPLYGGML 1951



 Score = 45.8 bits (107), Expect = 6e-04
 Identities = 153/746 (20%), Positives = 246/746 (32%), Gaps = 102/746 (13%)

Query: 285 EGTPKGS-RPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAA 343
           +G P+G  +PPL    Q  P   P+   P      P ++    K +   + EK +S+   
Sbjct: 200 QGKPEGIIKPPL---QQQPPKPIPKQQGPG---RDPLQQDGTPKSISSQQPEKIKSQPPG 253

Query: 344 MYDIISSPSK----DSTKLTLRLSRVRSSDMDQQEDMISG--VENSNVSENDIPFN---- 393
               I  P++    D  KL L+  R  S    +Q D++ G  V+ S  S +  P      
Sbjct: 254 TGKPIQGPTQTPQTDHAKLPLQ--RDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTP 311

Query: 394 ----VQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQ 449
                Q PG     P   +   +P    + L+QQ  T      + PV    T+    QP 
Sbjct: 312 GKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTV-----KPPVQPPGTTKPPAQPL 366

Query: 450 TSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQD--KDKPLKKRKQ 507
                  QQ   + P  ++    ALA+   + +  A +        Q     KPL ++  
Sbjct: 367 GPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPG 426

Query: 508 DSYPQEAGGAT-----------------GGNRPASQETGSTGNGSRPALMVSIDLHQAG- 549
              P +A G T                 G  + ++Q+TG T   S+          Q G 
Sbjct: 427 LQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGP 486

Query: 550 ------RVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKK 603
                 +  S    +Q   S K P +  Q   A  S  Q    GS K   +         
Sbjct: 487 AKPPPQQPGSAKPPSQQPGSTKPPPQ--QPGPAKPSPQQP---GSTKPPSQQPGSAKPSA 541

Query: 604 SDPELSKSEMKQSE---SRLAESKPNENRLVETKSSENKLETKVET-----QTEEL---- 651
             P  +K   +QS    S+    KP +   V   + +   +   +T      T EL    
Sbjct: 542 QQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHV 601

Query: 652 --KQNESRTTECKQNESTIV--EPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKG 707
             K N +  TEC+    ++    P  +   + +    + +            P +P+ K 
Sbjct: 602 PEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKL 661

Query: 708 ESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKN-------EGRPETPKH 760
           ++ P T           P+Q    +   PKQ     PE  K           G P     
Sbjct: 662 KTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAK 721

Query: 761 RHDNRRDSGKPSTEKKPEV--SKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDH 818
           +        KP+  K+P V   + K     D P+    + + +K   D  S S +  +  
Sbjct: 722 QPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPK----QPKMVKPTTDLVSSSSATTKPD 777

Query: 819 DNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSR 878
               K   + E +     ++   +P    S S    G K     +  + R        S 
Sbjct: 778 IPSSKVQSQAEEKTTPPLKTDSAKP----SQSFPPTGEKVSPFDSKAIPRPASDSKIISH 833

Query: 879 ERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFK---------SPTSKDDKRTEGNKSKVD 929
             PSS E K +     V++ +  K    K+  K         SPT    + T G      
Sbjct: 834 PGPSS-ESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTP 892

Query: 930 TNKAHPDNKAEFPSYLLGGRSGALKN 955
                P  ++   S  LG  + A K+
Sbjct: 893 QQSPKPQEQSRRFSLNLGSITDAPKS 918



 Score = 41.2 bits (95), Expect = 0.015
 Identities = 100/530 (18%), Positives = 188/530 (35%), Gaps = 71/530 (13%)

Query: 284 SEGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAA 343
           ++G PKGS PP   +S S+             LDS    ++  +    G+  +    K+ 
Sbjct: 63  AQGLPKGSVPPAAAESPSMHRKQE--------LDSSHPPKQSGRPPDPGRPAQPGLSKSR 114

Query: 344 MYDIISS----PSKDSTKLTLRLSRVRSSDMDQQED-MISGVEN--------SNVSENDI 390
             D   S    P +  + ++L+ S+ R+   ++ +  M+ G  +        S+V     
Sbjct: 115 TTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFN 174

Query: 391 PFNVQYPGQ------TSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVP---VLQQN- 440
           PF++    +      T K  +  ++  +P    +   QQ+    +P  Q P    LQQ+ 
Sbjct: 175 PFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDG 234

Query: 441 --TSVAAKQPQTSVVQ-----NQQQISQQGPIYDEVELDALAEIERIERESA--IERERF 491
              S++++QP+    Q        Q   Q P  D  +L    +  R + + A  +  E  
Sbjct: 235 TPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESV 294

Query: 492 SKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQ---ETGSTGNGSRPALMVSIDLHQA 548
              +    KP  ++            T G  PA Q   E    G    PA    +    A
Sbjct: 295 KPSLPSPSKPPIQQP-----------TPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLA 343

Query: 549 GRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPEL 608
            +  +     Q   + K P +       P      +   S +  P+   + P     P  
Sbjct: 344 QQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQ 403

Query: 609 SKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTI 668
                K    ++   KP    L +    ++  +    T+T   +    +    +      
Sbjct: 404 QPGPAKPPTQQVGTPKP----LAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPG-- 457

Query: 669 VEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETP--KQKGESRPETPKQKSDGHPETPK 726
              K +  +   TKP        +    +  P  P  +Q G ++P  P Q+       P+
Sbjct: 458 ---KTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKP--PSQQPGSTKPPPQ 512

Query: 727 QKGDGRPETPKQKGESRPETPKQKNEGRP--ETPKHRHDNRRDSGKPSTE 774
           Q G  +P +P+Q G ++P + +Q    +P  + P     + + S KP ++
Sbjct: 513 QPGPAKP-SPQQPGSTKPPS-QQPGSAKPSAQQPSPAKPSAQQSTKPVSQ 560



 Score = 35.4 bits (80), Expect = 0.80
 Identities = 41/195 (21%), Positives = 80/195 (41%), Gaps = 20/195 (10%)

Query: 28   LPSPLPATTTKSLLFNARIAEEVNCLLACRDDNL-----VSQLVHSLNQVSTDHIELKDN 82
            LP+P P   +            V+    CR + +     +  +   L+ V  +  +L+  
Sbjct: 3724 LPNPPPEEISTGTQSTFSTMGTVSRRRICRTNTMARAKILQDIDRELDLVERESAKLRKK 3783

Query: 83   LGS-DDPEGDIPVLLQ----AVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSP 137
                D+ E +I   L+     +  R   + +E+  + R    G+   +  +S + + S+ 
Sbjct: 3784 QAELDEEEKEIDAKLRYLEMGINRRKEALLKEREKRERAYLQGVAEDRDYMSDSEVSSTR 3843

Query: 138  ASSNYQQ------TTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAPQSPAGYMPYSH 191
             +    Q       T   +  S+F+PPQT + ++ +P   SP  + Y   SPA  +P   
Sbjct: 3844 PTRIESQHGIERPRTAPQTEFSQFIPPQTQTESQLVP-PTSPY-TQYQYSSPA--LPTQA 3899

Query: 192  PSSYTTHPQMQQASV 206
            P+SYT     +Q ++
Sbjct: 3900 PTSYTQQSHFEQQTL 3914


>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
          Length = 2039

 Score = 68.6 bits (166), Expect = 9e-11
 Identities = 130/670 (19%), Positives = 256/670 (38%), Gaps = 88/670 (13%)

Query: 567  PEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPN 626
            P+  K     P  VL      S +   +N   +      PE S S+M+  +  +   +  
Sbjct: 385  PKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHK 444

Query: 627  ENRLVETK-SSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNE--NRLSDTKP 683
            +   V+ K  ++NK +   E + E+  +  +R T    N       K  E  N      P
Sbjct: 445  QKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSP 504

Query: 684  NDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDG----RPETPK-- 737
             D+   +    +T   P+      E +    KQ+   H +T    G      +P+  +  
Sbjct: 505  KDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQE---HTKTCLSPGSSEMSLQPDLVRYD 561

Query: 738  -QKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSE 796
              + E  PE+   K+    E  KH+ D   + G+ S  K  +        +  SP  ++ 
Sbjct: 562  NTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKD--------EDHSPTFENS 613

Query: 797  RAEALKQRPDGRSVSESLRRDHD---NKQKSDDRGESERHRGDQS--RVRRPETLRSSSR 851
                 K   +G+++ +   +  +    K K +  GE E+++   S   ++R         
Sbjct: 614  DCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFW 673

Query: 852  NEHGIKSDSS---------------KTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVK 896
             E+  KSD +               K  KLE K+  +   ++E+  S E+  + +  ++K
Sbjct: 674  KENFFKSDETEDLFLNMEHESLTLEKKSKLE-KNIKDDKSTKEKHVSKERNFKEERDKIK 732

Query: 897  QGDSNKSRSDKL------GFKSPTSKDDKRTEGNKSKVD-------TNKAHPDNKAEFPS 943
            +      R +K+          PT KD + T    S ++         K     K E   
Sbjct: 733  KESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQE--K 790

Query: 944  YLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVV 1003
            ++   +    K   I +   +K    T E K+ ++K E K + +K+ L E ++K    + 
Sbjct: 791  HIKESKEKPEKRSQIKEKDIEKMERKTFE-KEKKIKHEHKSEKDKLDLSECVDK----IK 845

Query: 1004 VLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTM 1063
               KL     +K  K+ E KS+++    K    + ++  +D+   KE P           
Sbjct: 846  EKDKLYSHHTEKCHKEGE-KSKNTAAIKKTDDREKSREKMDRKHDKEKP----------- 893

Query: 1064 PLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRR 1123
                     +++R     K K+     ++ +D+ E  +S + ++K+ D +  + E+   +
Sbjct: 894  ---------EKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDK 944

Query: 1124 SSGDHRRSGHSHEGRRSS--GGGRYRNRSP---SDSDMEDYSPPPSLSEVARKMKKKEKQ 1178
             S +   S H  E ++SS   G + ++  P    +   ++    P   E  +K K  ++ 
Sbjct: 945  ESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRY 1004

Query: 1179 KKRKAYEPKL 1188
            K+R  ++ K+
Sbjct: 1005 KERDKHKDKI 1014



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 111/562 (19%), Positives = 223/562 (39%), Gaps = 78/562 (13%)

Query: 560  DSDSIKKPEEIKQCNDAPVSVLQEDI------VGSLKSTPENHPETPK------KKSDPE 607
            +S+ + +   +K C     S  Q+D         + K   E+H  T +      KK D E
Sbjct: 564  ESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKE 623

Query: 608  ---LSKSEMKQSESRLAESKPN---ENRLVETKSSENKLETKVETQTEELKQNESRTTEC 661
               L K ++K  E    + K     E    +TK S  +L+  VE   E  K+N  ++ E 
Sbjct: 624  GKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDET 683

Query: 662  K------QNESTIVEPKQN-ENRLSDTKPND----NKQNNGRSETTKSRPETPKQKGESR 710
            +      ++ES  +E K   E  + D K       +K+ N + E  K + E+ K   E +
Sbjct: 684  EDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEK 743

Query: 711  PETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGK 770
             +  K++ +  P     +      +  ++        K+ +  + E  KH  +++    K
Sbjct: 744  IKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQE--KHIKESKEKPEK 801

Query: 771  PSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGES 830
             S  K+ ++ K ++ T     ++K E     K   D   +SE + +  +  +      E 
Sbjct: 802  RSQIKEKDIEKMERKTFEKEKKIKHEH----KSEKDKLDLSECVDKIKEKDKLYSHHTEK 857

Query: 831  ERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKT---DKLERKHRHESGDSRERPSSGEQK 887
                G++S+            N   IK    +    +K++RKH  E  +     +  ++K
Sbjct: 858  CHKEGEKSK------------NTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEK 905

Query: 888  SRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEG-NKSKVD-TNKAHPDNKAEFPSYL 945
               +    +  +S  S+S+K   K    + DK+ +  +K  ++ TN  H   + E  S +
Sbjct: 906  HLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKH--IQEEKKSSI 963

Query: 946  LGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMK---GEPKDKVEKIGLVEDLNKGAKPV 1002
            + G           K + +K  ++ ++TK   +K   G+ KDK +K     D+++  +  
Sbjct: 964  VDGN----------KAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDK-----DIDRYKERD 1008

Query: 1003 VVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIEST 1062
                K+ ++ + KL K   DK +    P         K  ++  +++     +L     +
Sbjct: 1009 KHKDKIQINSLLKL-KSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERML-----S 1062

Query: 1063 MPLCERVKMNKRKRSTVNEKPK 1084
            +   E  + +K+ +  + +K K
Sbjct: 1063 LKDLEIEQWHKKHKEKIKQKEK 1084



 Score = 52.0 bits (123), Expect = 8e-06
 Identities = 67/345 (19%), Positives = 136/345 (39%), Gaps = 43/345 (12%)

Query: 551  VDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSK 610
            V  + +  ++ D IKK  E            +E+ +  LK   EN P T K      L  
Sbjct: 718  VSKERNFKEERDKIKKESE---------KSFREEKIKDLKEERENIP-TDKDSEFTSLGM 767

Query: 611  SEMKQS---------------ESRLAESKPNENRLVETKSSE-NKLETKVETQTEELKQN 654
            S +++S               E  + ESK    +  + K  +  K+E K   + +++K +
Sbjct: 768  SAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIK-H 826

Query: 655  ESRTTECKQNESTIVEPKQNENRLSDT------KPNDNKQNNGRSETTKSRPETPKQKGE 708
            E ++ + K + S  V+  + +++L         K  +  +N    + T  R E  ++K +
Sbjct: 827  EHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDR-EKSREKMD 885

Query: 709  SRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDS 768
             + +  K + + H    K+K        ++K +    +   K+E      K R  ++++ 
Sbjct: 886  RKHDKEKPEKERHLAESKEK-----HLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEK 940

Query: 769  GKPSTEKKPEVSKHKQDTKS----DSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKS 824
             +         SKH Q+ K     D  + + E+  +LK++     +     ++ D K K 
Sbjct: 941  SRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKD 1000

Query: 825  DDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERK 869
             DR +      D+ ++     L+S +       S +SK  + + K
Sbjct: 1001 IDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEK 1045



 Score = 40.0 bits (92), Expect = 0.032
 Identities = 41/181 (22%), Positives = 71/181 (39%), Gaps = 8/181 (4%)

Query: 665 ESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPET 724
           +S   +P Q+EN  SD+   +        +   S  +TPK +     +  K+KS    + 
Sbjct: 3   KSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKL 62

Query: 725 PKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQ 784
           P      R E  ++  ++  E P++K   +    K         G P +E+K      + 
Sbjct: 63  PFTISPSRNE--ERDSDTEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQM 120

Query: 785 DTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERH----RGDQSRV 840
             + +SP   S      +  P  +    S  R  D   K ++RGE+  H    RGD  +V
Sbjct: 121 TARDNSP--DSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQV 178

Query: 841 R 841
           +
Sbjct: 179 K 179



 Score = 37.7 bits (86), Expect = 0.16
 Identities = 44/172 (25%), Positives = 69/172 (40%), Gaps = 22/172 (12%)

Query: 610 KSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQ--TEELKQNESRTTECKQNEST 667
           +SE   S+S + E KP   +  +  +S +K   K+E    ++E+K+  S     K+    
Sbjct: 11  QSENSDSDSNMVE-KPYGRKSKDKIASYSKTP-KIERSDVSKEMKEKSSM----KRKLPF 64

Query: 668 IVEPKQNENRLSDTKPN--DNKQNNGRSETTKSRP---------ETPKQKGESRPETPKQ 716
            + P +NE R SDT+    + K+    +   KS P            KQ       T + 
Sbjct: 65  TISPSRNEERDSDTEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARD 124

Query: 717 KS-DGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRD 767
            S D  P  P Q    + +TP      + +  K+   G  ETP H    R D
Sbjct: 125 NSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERG--ETPLHMAAIRGD 174



 Score = 33.1 bits (74), Expect = 4.0
 Identities = 25/80 (31%), Positives = 41/80 (51%), Gaps = 8/80 (10%)

Query: 2443 QEEPLFI-MHHIDITLSVSGS---NLL--QSFKESMVKDKR--KERKSSPSKENESSDSE 2494
            + E LF+ M H  +TL        N+   +S KE  V  +R  KE +    KE+E S  E
Sbjct: 682  ETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFRE 741

Query: 2495 EEVSRPRKSRKRVDSDSDSD 2514
            E++   ++ R+ + +D DS+
Sbjct: 742  EKIKDLKEERENIPTDKDSE 761


>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
          Length = 2062

 Score = 68.6 bits (166), Expect = 9e-11
 Identities = 130/670 (19%), Positives = 256/670 (38%), Gaps = 88/670 (13%)

Query: 567  PEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPN 626
            P+  K     P  VL      S +   +N   +      PE S S+M+  +  +   +  
Sbjct: 408  PKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHK 467

Query: 627  ENRLVETK-SSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNE--NRLSDTKP 683
            +   V+ K  ++NK +   E + E+  +  +R T    N       K  E  N      P
Sbjct: 468  QKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSP 527

Query: 684  NDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDG----RPETPK-- 737
             D+   +    +T   P+      E +    KQ+   H +T    G      +P+  +  
Sbjct: 528  KDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQE---HTKTCLSPGSSEMSLQPDLVRYD 584

Query: 738  -QKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSE 796
              + E  PE+   K+    E  KH+ D   + G+ S  K  +        +  SP  ++ 
Sbjct: 585  NTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKD--------EDHSPTFENS 636

Query: 797  RAEALKQRPDGRSVSESLRRDHD---NKQKSDDRGESERHRGDQS--RVRRPETLRSSSR 851
                 K   +G+++ +   +  +    K K +  GE E+++   S   ++R         
Sbjct: 637  DCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFW 696

Query: 852  NEHGIKSDSS---------------KTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVK 896
             E+  KSD +               K  KLE K+  +   ++E+  S E+  + +  ++K
Sbjct: 697  KENFFKSDETEDLFLNMEHESLTLEKKSKLE-KNIKDDKSTKEKHVSKERNFKEERDKIK 755

Query: 897  QGDSNKSRSDKL------GFKSPTSKDDKRTEGNKSKVD-------TNKAHPDNKAEFPS 943
            +      R +K+          PT KD + T    S ++         K     K E   
Sbjct: 756  KESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQE--K 813

Query: 944  YLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVV 1003
            ++   +    K   I +   +K    T E K+ ++K E K + +K+ L E ++K    + 
Sbjct: 814  HIKESKEKPEKRSQIKEKDIEKMERKTFE-KEKKIKHEHKSEKDKLDLSECVDK----IK 868

Query: 1004 VLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTM 1063
               KL     +K  K+ E KS+++    K    + ++  +D+   KE P           
Sbjct: 869  EKDKLYSHHTEKCHKEGE-KSKNTAAIKKTDDREKSREKMDRKHDKEKP----------- 916

Query: 1064 PLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRR 1123
                     +++R     K K+     ++ +D+ E  +S + ++K+ D +  + E+   +
Sbjct: 917  ---------EKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDK 967

Query: 1124 SSGDHRRSGHSHEGRRSS--GGGRYRNRSP---SDSDMEDYSPPPSLSEVARKMKKKEKQ 1178
             S +   S H  E ++SS   G + ++  P    +   ++    P   E  +K K  ++ 
Sbjct: 968  ESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRY 1027

Query: 1179 KKRKAYEPKL 1188
            K+R  ++ K+
Sbjct: 1028 KERDKHKDKI 1037



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 111/562 (19%), Positives = 223/562 (39%), Gaps = 78/562 (13%)

Query: 560  DSDSIKKPEEIKQCNDAPVSVLQEDI------VGSLKSTPENHPETPK------KKSDPE 607
            +S+ + +   +K C     S  Q+D         + K   E+H  T +      KK D E
Sbjct: 587  ESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKE 646

Query: 608  ---LSKSEMKQSESRLAESKPN---ENRLVETKSSENKLETKVETQTEELKQNESRTTEC 661
               L K ++K  E    + K     E    +TK S  +L+  VE   E  K+N  ++ E 
Sbjct: 647  GKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDET 706

Query: 662  K------QNESTIVEPKQN-ENRLSDTKPND----NKQNNGRSETTKSRPETPKQKGESR 710
            +      ++ES  +E K   E  + D K       +K+ N + E  K + E+ K   E +
Sbjct: 707  EDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEK 766

Query: 711  PETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGK 770
             +  K++ +  P     +      +  ++        K+ +  + E  KH  +++    K
Sbjct: 767  IKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQE--KHIKESKEKPEK 824

Query: 771  PSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGES 830
             S  K+ ++ K ++ T     ++K E     K   D   +SE + +  +  +      E 
Sbjct: 825  RSQIKEKDIEKMERKTFEKEKKIKHEH----KSEKDKLDLSECVDKIKEKDKLYSHHTEK 880

Query: 831  ERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKT---DKLERKHRHESGDSRERPSSGEQK 887
                G++S+            N   IK    +    +K++RKH  E  +     +  ++K
Sbjct: 881  CHKEGEKSK------------NTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEK 928

Query: 888  SRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEG-NKSKVD-TNKAHPDNKAEFPSYL 945
               +    +  +S  S+S+K   K    + DK+ +  +K  ++ TN  H   + E  S +
Sbjct: 929  HLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKH--IQEEKKSSI 986

Query: 946  LGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMK---GEPKDKVEKIGLVEDLNKGAKPV 1002
            + G           K + +K  ++ ++TK   +K   G+ KDK +K     D+++  +  
Sbjct: 987  VDGN----------KAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDK-----DIDRYKERD 1031

Query: 1003 VVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIEST 1062
                K+ ++ + KL K   DK +    P         K  ++  +++     +L     +
Sbjct: 1032 KHKDKIQINSLLKL-KSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERML-----S 1085

Query: 1063 MPLCERVKMNKRKRSTVNEKPK 1084
            +   E  + +K+ +  + +K K
Sbjct: 1086 LKDLEIEQWHKKHKEKIKQKEK 1107



 Score = 52.0 bits (123), Expect = 8e-06
 Identities = 67/345 (19%), Positives = 136/345 (39%), Gaps = 43/345 (12%)

Query: 551  VDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSK 610
            V  + +  ++ D IKK  E            +E+ +  LK   EN P T K      L  
Sbjct: 741  VSKERNFKEERDKIKKESE---------KSFREEKIKDLKEERENIP-TDKDSEFTSLGM 790

Query: 611  SEMKQS---------------ESRLAESKPNENRLVETKSSE-NKLETKVETQTEELKQN 654
            S +++S               E  + ESK    +  + K  +  K+E K   + +++K +
Sbjct: 791  SAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIK-H 849

Query: 655  ESRTTECKQNESTIVEPKQNENRLSDT------KPNDNKQNNGRSETTKSRPETPKQKGE 708
            E ++ + K + S  V+  + +++L         K  +  +N    + T  R E  ++K +
Sbjct: 850  EHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDR-EKSREKMD 908

Query: 709  SRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDS 768
             + +  K + + H    K+K        ++K +    +   K+E      K R  ++++ 
Sbjct: 909  RKHDKEKPEKERHLAESKEK-----HLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEK 963

Query: 769  GKPSTEKKPEVSKHKQDTKS----DSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKS 824
             +         SKH Q+ K     D  + + E+  +LK++     +     ++ D K K 
Sbjct: 964  SRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKD 1023

Query: 825  DDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERK 869
             DR +      D+ ++     L+S +       S +SK  + + K
Sbjct: 1024 IDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEK 1068



 Score = 38.5 bits (88), Expect = 0.094
 Identities = 50/193 (25%), Positives = 78/193 (40%), Gaps = 41/193 (21%)

Query: 610 KSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQ--TEELKQNESRTTECKQNEST 667
           +SE   S+S + E KP   +  +  +S +K   K+E    ++E+K+  S     K+    
Sbjct: 11  QSENSDSDSNMVE-KPYGRKSKDKIASYSKTP-KIERSDVSKEMKEKSSM----KRKLPF 64

Query: 668 IVEPKQNENRLSDT--KPNDNKQNNG-------RSETTKSRPETPKQKGE--SRPETPKQ 716
            + P +NE R SDT   P    +N G       R+ + K  PE  K K E  ++  TP  
Sbjct: 65  TISPSRNEERDSDTDSDPGHTSENWGERLISSYRTYSEKEGPEKKKTKKEAGNKKSTPVS 124

Query: 717 KSDGHPETPKQK-------------GDGRPETPKQKGESRPETPK---------QKNEGR 754
              G+P + +++              D  P  P Q   ++ +TP           K   R
Sbjct: 125 ILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNER 184

Query: 755 PETPKHRHDNRRD 767
            ETP H    R D
Sbjct: 185 GETPLHMAAIRGD 197



 Score = 35.8 bits (81), Expect = 0.61
 Identities = 43/202 (21%), Positives = 72/202 (35%), Gaps = 27/202 (13%)

Query: 665 ESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPET 724
           +S   +P Q+EN  SD+   +        +   S  +TPK +     +  K+KS    + 
Sbjct: 3   KSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKL 62

Query: 725 PKQKGDGRPETPKQKGESRP---------------ETPKQKNEGRPETPKHRHDNRRDS- 768
           P      R E      +S P                T  +K     +  K    N++ + 
Sbjct: 63  PFTISPSRNEERDSDTDSDPGHTSENWGERLISSYRTYSEKEGPEKKKTKKEAGNKKSTP 122

Query: 769 -----GKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQK 823
                G P +E+K      +   + +SP   S      +  P  +    S  R  D   K
Sbjct: 123 VSILFGYPLSERKQMALLMQMTARDNSP--DSTPNHPSQTTPAQKKTPSSSSRQKDKVNK 180

Query: 824 SDDRGESERH----RGDQSRVR 841
            ++RGE+  H    RGD  +V+
Sbjct: 181 RNERGETPLHMAAIRGDVKQVK 202



 Score = 33.1 bits (74), Expect = 4.0
 Identities = 25/80 (31%), Positives = 41/80 (51%), Gaps = 8/80 (10%)

Query: 2443 QEEPLFI-MHHIDITLSVSGS---NLL--QSFKESMVKDKR--KERKSSPSKENESSDSE 2494
            + E LF+ M H  +TL        N+   +S KE  V  +R  KE +    KE+E S  E
Sbjct: 705  ETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFRE 764

Query: 2495 EEVSRPRKSRKRVDSDSDSD 2514
            E++   ++ R+ + +D DS+
Sbjct: 765  EKIKDLKEERENIPTDKDSE 784


>gi|117676384 splicing factor, arginine/serine-rich 2, interacting
           protein [Homo sapiens]
          Length = 1463

 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 83/336 (24%), Positives = 133/336 (39%), Gaps = 55/336 (16%)

Query: 621 AESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPK-------- 672
           +E+   +N L+ TK  E  LE K E+ TE  +  E   T  +Q +    E          
Sbjct: 663 SENNLLKNNLLNTKL-EKSLEEKNESLTEHPRSTELPKTHIEQIQKHFSEDNNEMIPMEC 721

Query: 673 ------QNENRLSDTKPNDNKQNNGRSETTKSRPETPKQK-GESRPETPKQKSDGHPET- 724
                 QNE+ +  +   D KQ N  S T  S    P     + + ET  Q S+   +T 
Sbjct: 722 DSFCSDQNESEVEPSVNADLKQMNENSVTHCSENNMPSSDLADEKVETVSQPSESPKDTI 781

Query: 725 -----PKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEV 779
                P+ +   R  +P        +TP++K   RP++P  R    R++GK S       
Sbjct: 782 DKTKKPRTRRS-RFHSPSTTWSPNKDTPQEKK--RPQSPSPR----RETGKESR------ 828

Query: 780 SKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSR 839
                  KS SP  K+E A   K+        +  R    ++ +S  R  +   R  +S 
Sbjct: 829 -------KSQSPSPKNESARGRKKSRSQSPKKDIARERRQSQSRSPKRDTTRESRRSESL 881

Query: 840 VRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGD 899
             R ET R + R++  +K DSS  +K           SRER S  + + R    R ++  
Sbjct: 882 SPRRETSRENKRSQPRVK-DSSPGEK-------SRSQSRERESDRDGQRRERERRTRKWS 933

Query: 900 SNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHP 935
            ++S S     +SP+    K    +  ++D +   P
Sbjct: 934 RSRSHS-----RSPSRCRTKSKSSSFGRIDRDSYSP 964



 Score = 57.4 bits (137), Expect = 2e-07
 Identities = 84/395 (21%), Positives = 145/395 (36%), Gaps = 52/395 (13%)

Query: 574  NDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVET 633
            N+ P S L ++ V ++    E+  +T  K   P   +S      +  + +K         
Sbjct: 755  NNMPSSDLADEKVETVSQPSESPKDTIDKTKKPRTRRSRFHSPSTTWSPNKDTPQEKKRP 814

Query: 634  KSSENKLETKVETQTEELK--QNESRTTECKQNESTIVEPKQNENRLSDTKP--NDNKQN 689
            +S   + ET  E++  +    +NES     K    +  +    E R S ++    D  + 
Sbjct: 815  QSPSPRRETGKESRKSQSPSPKNESARGRKKSRSQSPKKDIARERRQSQSRSPKRDTTRE 874

Query: 690  NGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQ 749
            + RSE+   R ET ++   S+P   K  S G     K +   R     + G+ R    + 
Sbjct: 875  SRRSESLSPRRETSRENKRSQPRV-KDSSPGE----KSRSQSRERESDRDGQRRERERRT 929

Query: 750  KNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSE---------RAEA 800
            +   R  +        R   K S       S  + D  S SPR K           R   
Sbjct: 930  RKWSRSRSHSRSPSRCRTKSKSS-------SFGRIDRDSYSPRWKGRWANDGWRCPRGND 982

Query: 801  LKQRPDGRSVSESLRRD-HDNKQKSDDRGESERHRGD-------------QSRVRRPETL 846
              ++ D    +E+ R++ +D    +DD   +++HR D               R R PE L
Sbjct: 983  RYRKNDPEKQNENTRKEKNDIHLDADDPNSADKHRNDCPNWITEKINSGPDPRTRNPEKL 1042

Query: 847  RSS----SRNEHGIKSDSSKTDKLERKHRHESGDSRERPS-------SGEQKSRPDSPRV 895
            + S    +RNE+   S +         +R     +R R +         + ++R  + + 
Sbjct: 1043 KESHWEENRNENSGNSWNKNFGSGWVSNRGRGRGNRGRGTYRSSFAYKDQNENRWQNRKP 1102

Query: 896  KQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDT 930
              G+SN S S+   FK    +  KR    +   DT
Sbjct: 1103 LSGNSNSSGSE--SFKFVEQQSYKRKSEQEFSFDT 1135



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 80/407 (19%), Positives = 154/407 (37%), Gaps = 32/407 (7%)

Query: 553 SQASITQDSDSIKKPEEIKQCNDAPVSVLQ-------------EDIVGSLKSTPENHPET 599
           SQ+ +  D  ++  P +   C  +   V Q             E +V   K T  +  E 
Sbjct: 533 SQSEVKTDVCTVHLPNDFPTCLTSESKVYQPVSCPLSDLSENVESVVNEEKITESSLVEI 592

Query: 600 PKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVE----TQTEELKQNE 655
            + K D  L   E+ +S     + + +E  +++T   ++    +V+     +TE+++   
Sbjct: 593 TEHK-DFTLKTEELIESP----KLESSEGEIIQTVDRQSVKSPEVQLLGHVETEDVEIIA 647

Query: 656 SRTTECKQNESTIVEPKQN--ENRLSDTKPNDNKQNNGRSETTKSRP-ETPKQKGESRPE 712
           +  T   ++ + I + + N  +N L +TK   + +    S T   R  E PK   E   +
Sbjct: 648 TCDTFGNEDFNNIQDSENNLLKNNLLNTKLEKSLEEKNESLTEHPRSTELPKTHIE---Q 704

Query: 713 TPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPS 772
             K  S+ + E    + D    + + + E  P       +    +  H  +N   S   +
Sbjct: 705 IQKHFSEDNNEMIPMECDSFC-SDQNESEVEPSVNADLKQMNENSVTHCSENNMPSSDLA 763

Query: 773 TEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESER 832
            EK   VS+  +  K    + K  R    + R    S + S  +D   ++K        R
Sbjct: 764 DEKVETVSQPSESPKDTIDKTKKPRTR--RSRFHSPSTTWSPNKDTPQEKKRPQSPSPRR 821

Query: 833 HRGDQSRVRR-PETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPD 891
             G +SR  + P     S+R     +S S K D    + + +S   +   +   ++S   
Sbjct: 822 ETGKESRKSQSPSPKNESARGRKKSRSQSPKKDIARERRQSQSRSPKRDTTRESRRSESL 881

Query: 892 SPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNK 938
           SPR +    NK    ++   SP  K   ++   +S  D  +   + +
Sbjct: 882 SPRRETSRENKRSQPRVKDSSPGEKSRSQSRERESDRDGQRRERERR 928



 Score = 37.7 bits (86), Expect = 0.16
 Identities = 38/146 (26%), Positives = 63/146 (43%), Gaps = 14/146 (9%)

Query: 1023 KSRSSLKPI-KNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTV-- 1079
            +SR S  P  KN+ ++  K S  QS  K++  E   + +S  P  +  + ++R  S    
Sbjct: 826  ESRKSQSPSPKNESARGRKKSRSQSPKKDIARER-RQSQSRSPKRDTTRESRRSESLSPR 884

Query: 1080 NEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRR 1139
             E  +  + S     DS    +S  +  +++ D+  +  ER+RR+    R   HS     
Sbjct: 885  RETSRENKRSQPRVKDSSPGEKSRSQSRERESDRDGQRRERERRTRKWSRSRSHSR---- 940

Query: 1140 SSGGGRYRNRSPSDS----DMEDYSP 1161
                 R R +S S S    D + YSP
Sbjct: 941  --SPSRCRTKSKSSSFGRIDRDSYSP 964


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 91/478 (19%), Positives = 189/478 (39%), Gaps = 34/478 (7%)

Query: 476 EIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGS 535
           EIE  E  +   ++   ++ ++  K  K+++++   +   G+ G N+        T    
Sbjct: 161 EIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQ 220

Query: 536 RPALMVSIDLHQAGRVD--SQASITQDSDSI----KKPEEIKQCNDAPVSVLQEDIVGSL 589
              +++S+   Q    +   +    Q SD I    K  EE K+  +A  + L+ +    +
Sbjct: 221 EETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERI 280

Query: 590 KSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPN----ENRLVETKSSENKLETKVE 645
           K+  +      + + + E  K+  ++ E R AE +      E R  E +    + E +  
Sbjct: 281 KAEQDKKIADERARIEAE-EKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAA 339

Query: 646 TQTEELKQNESRTTE----CKQNESTIVEPKQNENRLSDTKPN-DNKQNNGRSETTKSRP 700
            + + +K+ E R  E     K+ E    E +Q      + K   + ++ N + E  K   
Sbjct: 340 EERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAM 399

Query: 701 ETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETP--KQKGESRPETPKQKNEGRPET- 757
           +  K KGE      +QK +G     K+  + + +T   K++GE +    + K E   E  
Sbjct: 400 QETKIKGEK----VEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDK 455

Query: 758 PKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQ----------RPDG 807
           P  + +  +D      ++  E  K   D K     +KS+  E +            RP G
Sbjct: 456 PTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGG 515

Query: 808 RSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLE 867
           R+  ++   +   + ++  R E  R R  ++     E L+   + E  ++ +  K  + E
Sbjct: 516 RASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLK-QKQQEAALELEELKKKREE 574

Query: 868 RKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNK 925
           R+   E  + R +    ++K R +  + +  +  + R  +   K     +D  ++  K
Sbjct: 575 RRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKK 632



 Score = 48.1 bits (113), Expect = 1e-04
 Identities = 88/501 (17%), Positives = 201/501 (40%), Gaps = 48/501 (9%)

Query: 317 DSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTK-LTLRLSRVRSSDMDQQED 375
           +  E+++++++K K G   + Q E   M +  ++ S++ T  ++L+  ++ S +  Q+E+
Sbjct: 186 EDKEKEEEEEEKPKRGSIGENQVE--VMVEEKTTESQEETVVMSLKNGQISSEEPKQEEE 243

Query: 376 MISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVP 435
              G +  +  E  +    +   +  +  +  ++  R + A Q     ++ A + A +  
Sbjct: 244 REQGSDEISHHEK-MEEEDKERAEAERARLEAEERER-IKAEQDKKIADERARIEAEEKA 301

Query: 436 VLQQNTSVAAKQPQTS-------------VVQNQQQISQQGPIYDEVELDALAEIERI-- 480
             Q+     A++ +               + + +++ +++     E E  A  E +RI  
Sbjct: 302 AAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKE 361

Query: 481 -ERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGS---- 535
            E+ +A ER+R   E ++K K ++++K++   +E   A    +   ++      G     
Sbjct: 362 EEKRAAEERQRARAEEEEKAK-VEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNE 420

Query: 536 --------RPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVG 587
                   + A++      +  +V ++    Q+     K EEIK          +E++  
Sbjct: 421 KKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKS 480

Query: 588 SLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQ 647
            +         T  K  + E    ++K +E+    S+P     V+TK +E   + +   +
Sbjct: 481 FMD---RKKGFTEVKSQNGEFMTHKLKHTENTF--SRPGGRASVDTKEAEGAPQVEAGKR 535

Query: 648 TEELKQNESRT-------TECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRP 700
            EEL++    T        + KQ E+ +   +  + R    K  + ++   + E    + 
Sbjct: 536 LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKL 595

Query: 701 ETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKH 760
              ++K   + E  +++++   +  K   DG  +  K      P+    K E R E    
Sbjct: 596 REEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEF--L 653

Query: 761 RHDNRRDSGKPSTEKKPEVSK 781
               ++ SG  ST +   VSK
Sbjct: 654 NKSVQKSSGVKSTHQAAIVSK 674



 Score = 45.8 bits (107), Expect = 6e-04
 Identities = 86/502 (17%), Positives = 189/502 (37%), Gaps = 47/502 (9%)

Query: 422 QQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIE 481
           Q+E++     +QV V  QN SV  ++ +T+    Q +   +    + +   A  E  R +
Sbjct: 54  QEEESLGQVTDQVEVNAQN-SVPDEEAKTTTTNTQVEGDDEAAFLERL---ARREERRQK 109

Query: 482 R-ESAIERER-FSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPAL 539
           R + A+ER++ F   + D    L  R+  +        T  N    +E  S     R  +
Sbjct: 110 RLQEALERQKEFDPTITDASLSLPSRRMQN-------DTAENETTEKEEKSESRQERYEI 162

Query: 540 MVSIDLHQAGRVDS--QASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHP 597
             +  + ++ + +    A   +  D  K+ EE ++     +   Q +++   K+T     
Sbjct: 163 EETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEE 222

Query: 598 ETPKKKSDPELSKSEMKQSESRLAESKP-NENRLVETKSSENKLETKVETQTEELKQNES 656
                  + ++S  E KQ E R   S   + +  +E +  E     +   + EE ++ ++
Sbjct: 223 TVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKA 282

Query: 657 RTTECKQNESTIVEPKQN------ENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESR 710
              +   +E   +E ++       E R ++ +    ++    +E  +   E  K+  E R
Sbjct: 283 EQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEER 342

Query: 711 PETPKQKSDGHPETPKQKGDGRP-----ETPKQKGESRPETPKQKNEGRPETPKHRHDN- 764
               +++     E  + K + +      +  + + E + +  +QK   + E  KH     
Sbjct: 343 QRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQET 402

Query: 765 --------RRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRR 816
                   ++  GK   EKK +  K +          K  + +A +         E L+ 
Sbjct: 403 KIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKR---------EKLQE 453

Query: 817 DHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGD 876
           D    +K + +   E+ + D+      ++     +    +KS + +    + KH   +  
Sbjct: 454 DKPTFKKEEIK--DEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFS 511

Query: 877 SRERPSSGEQKSRPDSPRVKQG 898
                +S + K    +P+V+ G
Sbjct: 512 RPGGRASVDTKEAEGAPQVEAG 533



 Score = 38.5 bits (88), Expect = 0.094
 Identities = 88/505 (17%), Positives = 183/505 (36%), Gaps = 85/505 (16%)

Query: 759  KHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSP---RLKSERAEALKQRPDGRSVSESLR 815
            + R + RR   +    +   ++  + D   +     R +  R E L+Q+ +  S+ +   
Sbjct: 5    ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64

Query: 816  RDHDNKQKSDDRGESE------RHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERK 869
            +   N Q S    E++      +  GD          R   R +  ++      + LER+
Sbjct: 65   QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQ------EALERQ 118

Query: 870  HRHE---SGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGF-------KSPTSKDDK 919
               +   +  S   PS   Q    ++   ++ + ++SR ++          KS    D +
Sbjct: 119  KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178

Query: 920  RTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMK 979
              E NK +   +K   + + E P      + G++    +  +  +K     +ET  M +K
Sbjct: 179  DAEENKKE---DKEKEEEEEEKP------KRGSIGENQVEVMVEEKTTESQEETVVMSLK 229

Query: 980  G------EPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDR---EDKSRSSLKP 1030
                   EPK + E+        +G+  +   +K+  +D ++   +R   E + R  +K 
Sbjct: 230  NGQISSEEPKQEEER-------EQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKA 282

Query: 1031 IKNKPSKSNKGSIDQSVL--------------KELPPELLAEIESTMPLCERVKMNKRKR 1076
             ++K     +  I+                  + +  E     E    + E  K    +R
Sbjct: 283  EQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEER 342

Query: 1077 STVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHE 1136
              + E+ K A        + ++     R+R + ++++  + EE+ R    + ++  H+ +
Sbjct: 343  QRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKK--HAMQ 400

Query: 1137 GRRSSG-------GGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLT 1189
              +  G        G++ N   +  D         L     K + +EK  K +A   KL 
Sbjct: 401  ETKIKGEKVEQKIEGKWVNEKKAQED--------KLQTAVLKKQGEEKGTKVQAKREKL- 451

Query: 1190 PEEMMDSSTFKRFTASIENILDNLE 1214
                 D  TFK+     E I  + E
Sbjct: 452  ---QEDKPTFKKEEIKDEKIKKDKE 473


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.128    0.356 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 105,535,783
Number of Sequences: 37866
Number of extensions: 5146763
Number of successful extensions: 37465
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 181
Number of HSP's successfully gapped in prelim test: 1308
Number of HSP's that attempted gapping in prelim test: 23139
Number of HSP's gapped (non-prelim): 11648
length of query: 2804
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2684
effective length of database: 13,703,598
effective search space: 36780457032
effective search space used: 36780457032
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 71 (32.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.