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Search of human proteins with 4757720
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4757720 activin A receptor, type IB isoform a precursor
[Homo sapiens]
(505 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4757720 activin A receptor, type IB isoform a precursor [Homo... 1040 0.0
gi|33598910 activin A receptor, type IB isoform b precursor [Hom... 962 0.0
gi|33598912 activin A receptor, type IB isoform c precursor [Hom... 867 0.0
gi|4759226 transforming growth factor, beta receptor I isoform 1... 692 0.0
gi|161333833 activin A receptor, type IC isoform 1 [Homo sapiens] 645 0.0
gi|161333835 activin A receptor, type IC isoform 2 [Homo sapiens] 613 e-175
gi|195963412 transforming growth factor, beta receptor I isoform... 579 e-165
gi|161333837 activin A receptor, type IC isoform 3 [Homo sapiens] 533 e-151
gi|4502431 bone morphogenetic protein receptor, type IB precurso... 471 e-133
gi|41349437 bone morphogenetic protein receptor, type IA precurs... 459 e-129
gi|166235898 activin A receptor, type I precursor [Homo sapiens] 445 e-125
gi|4501895 activin A receptor, type I precursor [Homo sapiens] 445 e-125
gi|116734714 activin A receptor type II-like 1 [Homo sapiens] 417 e-117
gi|116734712 activin A receptor type II-like 1 [Homo sapiens] 417 e-117
gi|161333839 activin A receptor, type IC isoform 4 [Homo sapiens] 391 e-109
gi|67782324 transforming growth factor, beta receptor II isoform... 227 2e-59
gi|67782326 transforming growth factor, beta receptor II isoform... 227 2e-59
gi|4501897 activin A receptor, type IIA precursor [Homo sapiens] 224 2e-58
gi|116734708 activin A receptor, type IIB precursor [Homo sapiens] 218 1e-56
gi|15451916 bone morphogenetic protein receptor type II precurso... 194 2e-49
gi|10198656 anti-Mullerian hormone receptor, type II [Homo sapiens] 173 4e-43
gi|187475373 c-src tyrosine kinase [Homo sapiens] 92 1e-18
gi|4758078 c-src tyrosine kinase [Homo sapiens] 92 1e-18
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 86 8e-17
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 86 8e-17
gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Hom... 82 9e-16
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso... 80 3e-15
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso... 80 3e-15
gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso... 80 3e-15
gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof... 80 3e-15
>gi|4757720 activin A receptor, type IB isoform a precursor [Homo
sapiens]
Length = 505
Score = 1040 bits (2690), Expect = 0.0
Identities = 505/505 (100%), Positives = 505/505 (100%)
Query: 1 MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD 60
MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD
Sbjct: 1 MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD 60
Query: 61 GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS 120
GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS
Sbjct: 61 GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS 120
Query: 121 MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ 180
MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ
Sbjct: 121 MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ 180
Query: 181 DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE 240
DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE
Sbjct: 181 DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE 240
Query: 241 ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT 300
ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT
Sbjct: 241 ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT 300
Query: 301 IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH 360
IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH
Sbjct: 301 IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH 360
Query: 361 DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG 420
DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG
Sbjct: 361 DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG 420
Query: 421 GVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYAN 480
GVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYAN
Sbjct: 421 GVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYAN 480
Query: 481 GAARLTALRIKKTLSQLSVQEDVKI 505
GAARLTALRIKKTLSQLSVQEDVKI
Sbjct: 481 GAARLTALRIKKTLSQLSVQEDVKI 505
>gi|33598910 activin A receptor, type IB isoform b precursor [Homo
sapiens]
Length = 476
Score = 962 bits (2486), Expect = 0.0
Identities = 464/464 (100%), Positives = 464/464 (100%)
Query: 1 MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD 60
MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD
Sbjct: 1 MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD 60
Query: 61 GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS 120
GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS
Sbjct: 61 GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS 120
Query: 121 MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ 180
MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ
Sbjct: 121 MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ 180
Query: 181 DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE 240
DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE
Sbjct: 181 DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE 240
Query: 241 ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT 300
ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT
Sbjct: 241 ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT 300
Query: 301 IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH 360
IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH
Sbjct: 301 IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH 360
Query: 361 DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG 420
DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG
Sbjct: 361 DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG 420
Query: 421 GVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYE 464
GVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYE
Sbjct: 421 GVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYE 464
>gi|33598912 activin A receptor, type IB isoform c precursor [Homo
sapiens]
Length = 487
Score = 867 bits (2241), Expect = 0.0
Identities = 421/421 (100%), Positives = 421/421 (100%)
Query: 1 MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD 60
MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD
Sbjct: 1 MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD 60
Query: 61 GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS 120
GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS
Sbjct: 61 GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS 120
Query: 121 MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ 180
MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ
Sbjct: 121 MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ 180
Query: 181 DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE 240
DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE
Sbjct: 181 DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE 240
Query: 241 ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT 300
ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT
Sbjct: 241 ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT 300
Query: 301 IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH 360
IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH
Sbjct: 301 IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH 360
Query: 361 DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG 420
DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG
Sbjct: 361 DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG 420
Query: 421 G 421
G
Sbjct: 421 G 421
>gi|4759226 transforming growth factor, beta receptor I isoform 1
precursor [Homo sapiens]
Length = 503
Score = 692 bits (1787), Expect = 0.0
Identities = 351/510 (68%), Positives = 405/510 (79%), Gaps = 15/510 (2%)
Query: 3 ESAGASSFFPLVVLLLAGSGGSGPR---GVQALLCACTSCLQANYTCETDGACMVSIFNL 59
E+A A+ L++L+LA + + G AL C C C + N+TC TDG C VS+
Sbjct: 2 EAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTET 61
Query: 60 DGMEHHVRTCIPKVELVPAGKPFYCLSSE---DLRNTHCCYTDYCNRIDLRVPSGHLKEP 116
H CI +++L+P +PF C S + T+CC D+CN+I+L P+ P
Sbjct: 62 TDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIEL--PTTVKSSP 119
Query: 117 EHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEM-CLSK 175
GPVEL +IAGPV F+ I ++ +V H R + + + EDPS + +S+
Sbjct: 120 G----LGPVELAAVIAGPV--CFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISE 173
Query: 176 DKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKI 235
TL+DL+YD++TSGSGSGLPL VQRT+ARTIVLQE IGKGRFGEVWRG+WRG +VAVKI
Sbjct: 174 GTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKI 233
Query: 236 FSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLN 295
FSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLN
Sbjct: 234 FSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLN 293
Query: 296 RYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLG 355
RYTVT+EGMIKLALS ASGLAHLHMEIVGTQGKP IAHRDLKSKNILVKKNG C IADLG
Sbjct: 294 RYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLG 353
Query: 356 LAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIAR 415
LAVRHD+ TDTIDIAPN RVGTKRYMAPEVLD++INMKHF+SFK ADIYA+GLV+WEIAR
Sbjct: 354 LAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIAR 413
Query: 416 RCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRE 475
RC+ GG+HE+YQLPYYDLVPSDPS+EEMRKVVC+QKLRPNIPN WQS EALRVM K+MRE
Sbjct: 414 RCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRE 473
Query: 476 CWYANGAARLTALRIKKTLSQLSVQEDVKI 505
CWYANGAARLTALRIKKTLSQLS QE +K+
Sbjct: 474 CWYANGAARLTALRIKKTLSQLSQQEGIKM 503
>gi|161333833 activin A receptor, type IC isoform 1 [Homo sapiens]
Length = 493
Score = 645 bits (1663), Expect = 0.0
Identities = 323/491 (65%), Positives = 384/491 (78%), Gaps = 12/491 (2%)
Query: 15 VLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVE 74
+LLLA + P L C C C +N+TC+T+GAC S+ +G E +++C+ E
Sbjct: 13 LLLLAAAAELSP----GLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPE 68
Query: 75 LVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGP 134
L +C SS ++ T CC+TD+CN I L +P+ P P + GP+EL II P
Sbjct: 69 L---NAQVFCHSSNNVTKTECCFTDFCNNITLHLPTA---SPNAPKL-GPMELAIIITVP 121
Query: 135 VFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCL-SKDKTLQDLVYDLSTSGSGS 193
V LL + ++ Q Y ++R ++E+P E L + KTL+DL+YD++ SGSGS
Sbjct: 122 VCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGS 181
Query: 194 GLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQT 253
GLPL VQRT+ARTIVLQEI+GKGRFGEVW GRW G DVAVKIFSSR+ERSWFREAEIYQT
Sbjct: 182 GLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQT 241
Query: 254 VMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAAS 313
VMLRHENILGFIAADNKDNGTWTQLWLVS+YHE GSL+DYLNR VT+ GMIKLALS AS
Sbjct: 242 VMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIAS 301
Query: 314 GLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQ 373
GLAHLHMEIVGTQGKP IAHRD+KSKNILVKK CAIADLGLAV+HD++ +TIDI N
Sbjct: 302 GLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNP 361
Query: 374 RVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDL 433
+VGTKRYMAPE+LD+T+N+ F+SFK ADIY++GLVYWEIARRC+ GG+ EEYQLPYYD+
Sbjct: 362 KVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDM 421
Query: 434 VPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKT 493
VPSDPSIEEMRKVVCDQK RP+IPN WQS EALRVMG++MRECWYANGAARLTALRIKKT
Sbjct: 422 VPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKT 481
Query: 494 LSQLSVQEDVK 504
+SQL V+ED K
Sbjct: 482 ISQLCVKEDCK 492
>gi|161333835 activin A receptor, type IC isoform 2 [Homo sapiens]
Length = 443
Score = 613 bits (1581), Expect = e-175
Identities = 306/446 (68%), Positives = 360/446 (80%), Gaps = 8/446 (1%)
Query: 60 DGMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHP 119
+G E +++C+ EL +C SS ++ T CC+TD+CN I L +P+ P P
Sbjct: 4 NGKEQVIKSCVSLPEL---NAQVFCHSSNNVTKTECCFTDFCNNITLHLPTA---SPNAP 57
Query: 120 SMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCL-SKDKT 178
+ GP+EL II PV LL + ++ Q Y ++R ++E+P E L + KT
Sbjct: 58 KL-GPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKT 116
Query: 179 LQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSS 238
L+DL+YD++ SGSGSGLPL VQRT+ARTIVLQEI+GKGRFGEVW GRW G DVAVKIFSS
Sbjct: 117 LKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSS 176
Query: 239 REERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYT 298
R+ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVS+YHE GSL+DYLNR
Sbjct: 177 RDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNI 236
Query: 299 VTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAV 358
VT+ GMIKLALS ASGLAHLHMEIVGTQGKP IAHRD+KSKNILVKK CAIADLGLAV
Sbjct: 237 VTVAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAV 296
Query: 359 RHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCN 418
+HD++ +TIDI N +VGTKRYMAPE+LD+T+N+ F+SFK ADIY++GLVYWEIARRC+
Sbjct: 297 KHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCS 356
Query: 419 SGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWY 478
GG+ EEYQLPYYD+VPSDPSIEEMRKVVCDQK RP+IPN WQS EALRVMG++MRECWY
Sbjct: 357 VGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWY 416
Query: 479 ANGAARLTALRIKKTLSQLSVQEDVK 504
ANGAARLTALRIKKT+SQL V+ED K
Sbjct: 417 ANGAARLTALRIKKTISQLCVKEDCK 442
>gi|195963412 transforming growth factor, beta receptor I isoform 2
precursor [Homo sapiens]
Length = 426
Score = 579 bits (1492), Expect = e-165
Identities = 278/313 (88%), Positives = 297/313 (94%)
Query: 193 SGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQ 252
+GLPL VQRT+ARTIVLQE IGKGRFGEVWRG+WRG +VAVKIFSSREERSWFREAEIYQ
Sbjct: 114 TGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQ 173
Query: 253 TVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAA 312
TVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT+EGMIKLALS A
Sbjct: 174 TVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTA 233
Query: 313 SGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPN 372
SGLAHLHMEIVGTQGKP IAHRDLKSKNILVKKNG C IADLGLAVRHD+ TDTIDIAPN
Sbjct: 234 SGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPN 293
Query: 373 QRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYD 432
RVGTKRYMAPEVLD++INMKHF+SFK ADIYA+GLV+WEIARRC+ GG+HE+YQLPYYD
Sbjct: 294 HRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYD 353
Query: 433 LVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKK 492
LVPSDPS+EEMRKVVC+QKLRPNIPN WQS EALRVM K+MRECWYANGAARLTALRIKK
Sbjct: 354 LVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKK 413
Query: 493 TLSQLSVQEDVKI 505
TLSQLS QE +K+
Sbjct: 414 TLSQLSQQEGIKM 426
Score = 75.5 bits (184), Expect = 1e-13
Identities = 39/110 (35%), Positives = 59/110 (53%), Gaps = 6/110 (5%)
Query: 3 ESAGASSFFPLVVLLLAGSGGSGPR---GVQALLCACTSCLQANYTCETDGACMVSIFNL 59
E+A A+ L++L+LA + + G AL C C C + N+TC TDG C VS+
Sbjct: 2 EAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTET 61
Query: 60 DGMEHHVRTCIPKVELVPAGKPFYCLSSE---DLRNTHCCYTDYCNRIDL 106
H CI +++L+P +PF C S + T+CC D+CN+I+L
Sbjct: 62 TDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIEL 111
>gi|161333837 activin A receptor, type IC isoform 3 [Homo sapiens]
Length = 413
Score = 533 bits (1373), Expect = e-151
Identities = 257/312 (82%), Positives = 285/312 (91%)
Query: 193 SGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQ 252
+GLPL VQRT+ARTIVLQEI+GKGRFGEVW GRW G DVAVKIFSSR+ERSWFREAEIYQ
Sbjct: 101 TGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 160
Query: 253 TVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAA 312
TVMLRHENILGFIAADNKDNGTWTQLWLVS+YHE GSL+DYLNR VT+ GMIKLALS A
Sbjct: 161 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 220
Query: 313 SGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPN 372
SGLAHLHMEIVGTQGKP IAHRD+KSKNILVKK CAIADLGLAV+HD++ +TIDI N
Sbjct: 221 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 280
Query: 373 QRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYD 432
+VGTKRYMAPE+LD+T+N+ F+SFK ADIY++GLVYWEIARRC+ GG+ EEYQLPYYD
Sbjct: 281 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 340
Query: 433 LVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKK 492
+VPSDPSIEEMRKVVCDQK RP+IPN WQS EALRVMG++MRECWYANGAARLTALRIKK
Sbjct: 341 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK 400
Query: 493 TLSQLSVQEDVK 504
T+SQL V+ED K
Sbjct: 401 TISQLCVKEDCK 412
Score = 77.8 bits (190), Expect = 2e-14
Identities = 36/97 (37%), Positives = 55/97 (56%), Gaps = 7/97 (7%)
Query: 15 VLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVE 74
+LLLA + P L C C C +N+TC+T+GAC S+ +G E +++C+ E
Sbjct: 13 LLLLAAAAELSP----GLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPE 68
Query: 75 LVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSG 111
L +C SS ++ T CC+TD+CN I L +P+G
Sbjct: 69 L---NAQVFCHSSNNVTKTECCFTDFCNNITLHLPTG 102
>gi|4502431 bone morphogenetic protein receptor, type IB precursor
[Homo sapiens]
Length = 502
Score = 471 bits (1211), Expect = e-133
Identities = 248/469 (52%), Positives = 318/469 (67%), Gaps = 16/469 (3%)
Query: 43 NYTCETDGACMVSIFNLD-GMEHHVRTCIPKVELVPAGKPFYCLSS---EDLRNTHCCYT 98
N C TDG C I D G+ C+ G F C + R+ CC
Sbjct: 44 NNICSTDGYCFTMIEEDDSGLPVVTSGCLGL-----EGSDFQCRDTPIPHQRRSIECCTE 98
Query: 99 -DYCNRIDLRVPSGHLKEPEHPSMWGPVELVGI-IAGPVFLLFLIIIIVFLVINYHQRVY 156
+ CN+ DL LK + GP+ + I+ V L L++II+F Y ++
Sbjct: 99 RNECNK-DLHPTLPPLKNRDFVD--GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQET 155
Query: 157 HNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKG 216
R + +E E + ++L+DL+ +SGSGSGLPL VQRT+A+ I + + IGKG
Sbjct: 156 RPRYSIGLEQD--ETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKG 213
Query: 217 RFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWT 276
R+GEVW G+WRG VAVK+F + EE SWFRE EIYQTV++RHENILGFIAAD K G+WT
Sbjct: 214 RYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWT 273
Query: 277 QLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDL 336
QL+L++DYHE+GSL+DYL T+ + M+KLA S+ SGL HLH EI TQGKP IAHRDL
Sbjct: 274 QLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDL 333
Query: 337 KSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFD 396
KSKNILVKKNG C IADLGLAV+ + T+ +DI PN RVGTKRYM PEVLDE++N HF
Sbjct: 334 KSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQ 393
Query: 397 SFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNI 456
S+ AD+Y+ GL+ WE+ARRC SGG+ EEYQLPY+DLVPSDPS E+MR++VC +KLRP+
Sbjct: 394 SYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSF 453
Query: 457 PNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI 505
PN W S E LR MGK+M ECW N A+RLTALR+KKTL+++S +D+K+
Sbjct: 454 PNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIKL 502
>gi|41349437 bone morphogenetic protein receptor, type IA precursor
[Homo sapiens]
Length = 532
Score = 459 bits (1180), Expect = e-129
Identities = 243/473 (51%), Positives = 319/473 (67%), Gaps = 23/473 (4%)
Query: 43 NYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSE--DLRNT-HCCYTD 99
N TC T+G C I D E + + K E G F C S LR T CC T+
Sbjct: 73 NNTCITNGHCFAIIEEDDQGETTLASGCMKYE----GSDFQCKDSPKAQLRRTIECCRTN 128
Query: 100 YCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVI-------NYH 152
CN+ +L+ P + GP G I V L+ + + I+ ++I ++
Sbjct: 129 LCNQ--------YLQPTLPPVVIGPF-FDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHY 179
Query: 153 QRVYHNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEI 212
+ +R+R + + E + ++L+DL+ +SGSGSGLPL VQRT+A+ I +
Sbjct: 180 CKSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQ 239
Query: 213 IGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDN 272
+GKGR+GEVW G+WRG VAVK+F + EE SWFRE EIYQTV++RHENILGFIAAD K
Sbjct: 240 VGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGT 299
Query: 273 GTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIA 332
G+WTQL+L++DYHE+GSL+D+L T+ ++KLA SAA GL HLH EI GTQGKP IA
Sbjct: 300 GSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIA 359
Query: 333 HRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINM 392
HRDLKSKNIL+KKNG C IADLGLAV+ ++ T+ +D+ N RVGTKRYMAPEVLDE++N
Sbjct: 360 HRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNK 419
Query: 393 KHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKL 452
HF + ADIY+ GL+ WE+ARRC +GG+ EEYQLPYY++VPSDPS E+MR+VVC ++L
Sbjct: 420 NHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRL 479
Query: 453 RPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI 505
RP + N W S E LR + K+M ECW N A+RLTALRIKKTL+++ +DVKI
Sbjct: 480 RPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI 532
>gi|166235898 activin A receptor, type I precursor [Homo sapiens]
Length = 509
Score = 445 bits (1144), Expect = e-125
Identities = 244/472 (51%), Positives = 307/472 (65%), Gaps = 14/472 (2%)
Query: 33 LCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSEDLRN 92
+C C N C S+ DG + + C E GK +
Sbjct: 34 MCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYE---QGKMTCKTPPSPGQA 90
Query: 93 THCCYTDYCNR-IDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINY 151
CC D+CNR I ++P+ P + V L II VF + L+ ++ + +
Sbjct: 91 VECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGL--IILSVVFAVCLLACLLGVALRK 148
Query: 152 HQRVYHNRQRL---DMEDPSCEMCLSK---DKTLQDLVYDLSTSGSGSGLPLFVQRTVAR 205
+R N++RL D+E + E ++ D TL DL+ TSGSGSGLP VQRTVAR
Sbjct: 149 FKR--RNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVAR 206
Query: 206 TIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFI 265
I L E +GKGR+GEVWRG W+G +VAVKIFSSR+E+SWFRE E+Y TVMLRHENILGFI
Sbjct: 207 QITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFI 266
Query: 266 AADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGT 325
A+D + TQLWL++ YHE GSL+DYL T+ +++ LS ASGLAHLH+EI GT
Sbjct: 267 ASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGT 326
Query: 326 QGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEV 385
QGKP IAHRDLKSKNILVKKNG C IADLGLAV H T+ +D+ N RVGTKRYMAPEV
Sbjct: 327 QGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEV 386
Query: 386 LDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRK 445
LDETI + FDS+K DI+A GLV WE+ARR S G+ E+Y+ P+YD+VP+DPS E+MRK
Sbjct: 387 LDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRK 446
Query: 446 VVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQL 497
VVC + RPNIPN W S L + K+M+ECWY N +ARLTALRIKKTL+++
Sbjct: 447 VVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI 498
>gi|4501895 activin A receptor, type I precursor [Homo sapiens]
Length = 509
Score = 445 bits (1144), Expect = e-125
Identities = 244/472 (51%), Positives = 307/472 (65%), Gaps = 14/472 (2%)
Query: 33 LCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSEDLRN 92
+C C N C S+ DG + + C E GK +
Sbjct: 34 MCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYE---QGKMTCKTPPSPGQA 90
Query: 93 THCCYTDYCNR-IDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINY 151
CC D+CNR I ++P+ P + V L II VF + L+ ++ + +
Sbjct: 91 VECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGL--IILSVVFAVCLLACLLGVALRK 148
Query: 152 HQRVYHNRQRL---DMEDPSCEMCLSK---DKTLQDLVYDLSTSGSGSGLPLFVQRTVAR 205
+R N++RL D+E + E ++ D TL DL+ TSGSGSGLP VQRTVAR
Sbjct: 149 FKR--RNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVAR 206
Query: 206 TIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFI 265
I L E +GKGR+GEVWRG W+G +VAVKIFSSR+E+SWFRE E+Y TVMLRHENILGFI
Sbjct: 207 QITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFI 266
Query: 266 AADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGT 325
A+D + TQLWL++ YHE GSL+DYL T+ +++ LS ASGLAHLH+EI GT
Sbjct: 267 ASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGT 326
Query: 326 QGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEV 385
QGKP IAHRDLKSKNILVKKNG C IADLGLAV H T+ +D+ N RVGTKRYMAPEV
Sbjct: 327 QGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEV 386
Query: 386 LDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRK 445
LDETI + FDS+K DI+A GLV WE+ARR S G+ E+Y+ P+YD+VP+DPS E+MRK
Sbjct: 387 LDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRK 446
Query: 446 VVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQL 497
VVC + RPNIPN W S L + K+M+ECWY N +ARLTALRIKKTL+++
Sbjct: 447 VVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI 498
>gi|116734714 activin A receptor type II-like 1 [Homo sapiens]
Length = 503
Score = 417 bits (1073), Expect = e-117
Identities = 240/494 (48%), Positives = 302/494 (61%), Gaps = 22/494 (4%)
Query: 13 LVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGA-CMVSIFNLDG---MEHHVRT 68
L+ L+ G RG + C C S TC GA C V + +G EH R
Sbjct: 14 LMALVTQGDPVKPSRG-PLVTCTCESPHCKGPTCR--GAWCTVVLVREEGRHPQEH--RG 68
Query: 69 CIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELV 128
C + G+P + N +CC + CN V E P G + L
Sbjct: 69 CGNLHRELCRGRP------TEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLAL- 121
Query: 129 GIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSK----DKTLQDLVY 184
I GPV L ++ + L + + +R ++ L E + L D L DL+
Sbjct: 122 --ILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLD 179
Query: 185 DLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSW 244
T+GSGSGLP VQRTVAR + L E +GKGR+GEVWRG W G VAVKIFSSR+E+SW
Sbjct: 180 SDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSW 239
Query: 245 FREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGM 304
FRE EIY TV+LRH+NILGFIA+D + TQLWL++ YHEHGSL+D+L R T+
Sbjct: 240 FRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLA 299
Query: 305 IKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVT 364
++LA+SAA GLAHLH+EI GTQGKP IAHRD KS+N+LVK N C IADLGLAV H +
Sbjct: 300 LRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGS 359
Query: 365 DTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHE 424
D +DI N RVGTKRYMAPEVLDE I F+S+K DI+A GLV WEIARR G+ E
Sbjct: 360 DYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVE 419
Query: 425 EYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAAR 484
+Y+ P+YD+VP+DPS E+M+KVVC + P IPN + L + +MMRECWY N +AR
Sbjct: 420 DYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSAR 479
Query: 485 LTALRIKKTLSQLS 498
LTALRIKKTL ++S
Sbjct: 480 LTALRIKKTLQKIS 493
>gi|116734712 activin A receptor type II-like 1 [Homo sapiens]
Length = 503
Score = 417 bits (1073), Expect = e-117
Identities = 240/494 (48%), Positives = 302/494 (61%), Gaps = 22/494 (4%)
Query: 13 LVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGA-CMVSIFNLDG---MEHHVRT 68
L+ L+ G RG + C C S TC GA C V + +G EH R
Sbjct: 14 LMALVTQGDPVKPSRG-PLVTCTCESPHCKGPTCR--GAWCTVVLVREEGRHPQEH--RG 68
Query: 69 CIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELV 128
C + G+P + N +CC + CN V E P G + L
Sbjct: 69 CGNLHRELCRGRP------TEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLAL- 121
Query: 129 GIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSK----DKTLQDLVY 184
I GPV L ++ + L + + +R ++ L E + L D L DL+
Sbjct: 122 --ILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLD 179
Query: 185 DLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSW 244
T+GSGSGLP VQRTVAR + L E +GKGR+GEVWRG W G VAVKIFSSR+E+SW
Sbjct: 180 SDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSW 239
Query: 245 FREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGM 304
FRE EIY TV+LRH+NILGFIA+D + TQLWL++ YHEHGSL+D+L R T+
Sbjct: 240 FRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLA 299
Query: 305 IKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVT 364
++LA+SAA GLAHLH+EI GTQGKP IAHRD KS+N+LVK N C IADLGLAV H +
Sbjct: 300 LRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGS 359
Query: 365 DTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHE 424
D +DI N RVGTKRYMAPEVLDE I F+S+K DI+A GLV WEIARR G+ E
Sbjct: 360 DYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVE 419
Query: 425 EYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAAR 484
+Y+ P+YD+VP+DPS E+M+KVVC + P IPN + L + +MMRECWY N +AR
Sbjct: 420 DYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSAR 479
Query: 485 LTALRIKKTLSQLS 498
LTALRIKKTL ++S
Sbjct: 480 LTALRIKKTLQKIS 493
>gi|161333839 activin A receptor, type IC isoform 4 [Homo sapiens]
Length = 336
Score = 391 bits (1004), Expect = e-109
Identities = 187/234 (79%), Positives = 211/234 (90%)
Query: 271 DNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPG 330
DNGTWTQLWLVS+YHE GSL+DYLNR VT+ GMIKLALS ASGLAHLHMEIVGTQGKP
Sbjct: 102 DNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPA 161
Query: 331 IAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETI 390
IAHRD+KSKNILVKK CAIADLGLAV+HD++ +TIDI N +VGTKRYMAPE+LD+T+
Sbjct: 162 IAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTM 221
Query: 391 NMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQ 450
N+ F+SFK ADIY++GLVYWEIARRC+ GG+ EEYQLPYYD+VPSDPSIEEMRKVVCDQ
Sbjct: 222 NVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQ 281
Query: 451 KLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVK 504
K RP+IPN WQS EALRVMG++MRECWYANGAARLTALRIKKT+SQL V+ED K
Sbjct: 282 KFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCK 335
Score = 75.5 bits (184), Expect = 1e-13
Identities = 35/96 (36%), Positives = 54/96 (56%), Gaps = 7/96 (7%)
Query: 15 VLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVE 74
+LLLA + P L C C C +N+TC+T+GAC S+ +G E +++C+ E
Sbjct: 13 LLLLAAAAELSP----GLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPE 68
Query: 75 LVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPS 110
L +C SS ++ T CC+TD+CN I L +P+
Sbjct: 69 L---NAQVFCHSSNNVTKTECCFTDFCNNITLHLPT 101
>gi|67782324 transforming growth factor, beta receptor II isoform B
precursor [Homo sapiens]
Length = 567
Score = 227 bits (578), Expect = 2e-59
Identities = 144/445 (32%), Positives = 235/445 (52%), Gaps = 40/445 (8%)
Query: 69 CIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPV-EL 127
CI K + P F C S D N + +++ N +P + + ++
Sbjct: 121 CIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNT-------------SNPDLLLVIFQV 167
Query: 128 VGIIAGPVFLLFLIIIIVFLV--INYHQRVYHN----RQRLDME-DPSCEMCLSKDKTLQ 180
GI P + + +II+F +N Q++ + R ME C + L D++
Sbjct: 168 TGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRS-- 225
Query: 181 DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGD------VAVK 234
D+S++ + + T I L ++GKGRF EV++ + + VAVK
Sbjct: 226 ----DISSTCANN----INHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVK 277
Query: 235 IFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYL 294
IF E SW E +I+ + L+HENIL F+ A+ + Q WL++ +H G+L +YL
Sbjct: 278 IFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYL 337
Query: 295 NRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPG--IAHRDLKSKNILVKKNGMCAIA 352
R+ ++ E + KL S A G+AHLH + G+P I HRDLKS NILVK + C +
Sbjct: 338 TRHVISWEDLRKLGSSLARGIAHLHSDHTPC-GRPKMPIVHRDLKSSNILVKNDLTCCLC 396
Query: 353 DLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWE 412
D GL++R D D+A + +VGT RYMAPEVL+ +N+++ +SFK D+Y++ LV WE
Sbjct: 397 DFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWE 456
Query: 413 IARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKM 472
+ RCN+ G ++Y+ P+ V P +E M+ V + RP IP++W +++ ++++ +
Sbjct: 457 MTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCET 516
Query: 473 MRECWYANGAARLTALRIKKTLSQL 497
+ ECW + ARLTA + + S+L
Sbjct: 517 LTECWDHDPEARLTAQCVAERFSEL 541
>gi|67782326 transforming growth factor, beta receptor II isoform A
precursor [Homo sapiens]
Length = 592
Score = 227 bits (578), Expect = 2e-59
Identities = 144/445 (32%), Positives = 235/445 (52%), Gaps = 40/445 (8%)
Query: 69 CIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPV-EL 127
CI K + P F C S D N + +++ N +P + + ++
Sbjct: 146 CIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNT-------------SNPDLLLVIFQV 192
Query: 128 VGIIAGPVFLLFLIIIIVFLV--INYHQRVYHN----RQRLDME-DPSCEMCLSKDKTLQ 180
GI P + + +II+F +N Q++ + R ME C + L D++
Sbjct: 193 TGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRS-- 250
Query: 181 DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGD------VAVK 234
D+S++ + + T I L ++GKGRF EV++ + + VAVK
Sbjct: 251 ----DISSTCANN----INHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVK 302
Query: 235 IFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYL 294
IF E SW E +I+ + L+HENIL F+ A+ + Q WL++ +H G+L +YL
Sbjct: 303 IFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYL 362
Query: 295 NRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPG--IAHRDLKSKNILVKKNGMCAIA 352
R+ ++ E + KL S A G+AHLH + G+P I HRDLKS NILVK + C +
Sbjct: 363 TRHVISWEDLRKLGSSLARGIAHLHSDHTPC-GRPKMPIVHRDLKSSNILVKNDLTCCLC 421
Query: 353 DLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWE 412
D GL++R D D+A + +VGT RYMAPEVL+ +N+++ +SFK D+Y++ LV WE
Sbjct: 422 DFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWE 481
Query: 413 IARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKM 472
+ RCN+ G ++Y+ P+ V P +E M+ V + RP IP++W +++ ++++ +
Sbjct: 482 MTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCET 541
Query: 473 MRECWYANGAARLTALRIKKTLSQL 497
+ ECW + ARLTA + + S+L
Sbjct: 542 LTECWDHDPEARLTAQCVAERFSEL 566
>gi|4501897 activin A receptor, type IIA precursor [Homo sapiens]
Length = 513
Score = 224 bits (570), Expect = 2e-58
Identities = 141/426 (33%), Positives = 230/426 (53%), Gaps = 46/426 (10%)
Query: 84 CLSSEDLRNTH--CCYTDYCNR-------IDLRVPSGHLKEPEHPSMWGPVELVGIIAGP 134
C+ +D + CC + CN +++ P+ + P+ P + + L ++ P
Sbjct: 91 CVEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPP--YYNILLYSLV--P 146
Query: 135 VFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSG 194
+ L+ I+I F V +H+ Y + +DP G
Sbjct: 147 LMLIAGIVICAFWVYRHHKMAYPP-VLVPTQDP----------------------GPPPP 183
Query: 195 LPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTV 254
PL + + L E+ +GRFG VW+ + VAVKIF ++++SW E E+Y
Sbjct: 184 SPLLG----LKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLP 239
Query: 255 MLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASG 314
++HENIL FI A+ + LWL++ +HE GSL D+L V+ + +A + A G
Sbjct: 240 GMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARG 299
Query: 315 LAHLHMEIVGTQG--KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPN 372
LA+LH +I G + KP I+HRD+KSKN+L+K N IAD GLA++ +A D +
Sbjct: 300 LAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--TH 357
Query: 373 QRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG-GVHEEYQLPYY 431
+VGT+RYMAPEVL+ IN + D+F D+YA+GLV WE+A RC + G +EY LP+
Sbjct: 358 GQVGTRRYMAPEVLEGAINFQR-DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFE 416
Query: 432 DLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIK 491
+ + PS+E+M++VV +K RP + ++WQ + + ++ + + ECW + ARL+A +
Sbjct: 417 EEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVG 476
Query: 492 KTLSQL 497
+ ++Q+
Sbjct: 477 ERITQM 482
>gi|116734708 activin A receptor, type IIB precursor [Homo sapiens]
Length = 512
Score = 218 bits (555), Expect = 1e-56
Identities = 140/422 (33%), Positives = 227/422 (53%), Gaps = 42/422 (9%)
Query: 84 CLSSEDLRNTH--CCYTDYCNRIDLRVP-SGHLKEPEHPSMWGPVELVGIIAG--PVFLL 138
C+++E+ + CC ++CN +P +G + P P L + P+ L
Sbjct: 90 CVATEENPQVYFCCCEGNFCNERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGL 149
Query: 139 FLIIIIVFLVINYHQRVYHNRQRLDM-EDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPL 197
LI+++ F + + + Y + +D+ EDP G P
Sbjct: 150 SLIVLLAFWMYRHRKPPYGH---VDIHEDP--------------------------GPPP 180
Query: 198 FVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLR 257
+ + L EI +GRFG VW+ + VAVKIF ++++SW E EI+ T ++
Sbjct: 181 PSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMK 240
Query: 258 HENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAH 317
HEN+L FIAA+ + + +LWL++ +H+ GSL DYL +T + +A + + GL++
Sbjct: 241 HENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSY 300
Query: 318 LHMEIVGTQG---KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQR 374
LH ++ +G KP IAHRD KSKN+L+K + +AD GLAVR + D + +
Sbjct: 301 LHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQ 358
Query: 375 VGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG-GVHEEYQLPYYDL 433
VGT+RYMAPEVL+ IN + D+F D+YA+GLV WE+ RC + G +EY LP+ +
Sbjct: 359 VGTRRYMAPEVLEGAINFQR-DAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEE 417
Query: 434 VPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKT 493
+ PS+EE+++VV +K+RP I + W + L + + ECW + ARL+A +++
Sbjct: 418 IGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEER 477
Query: 494 LS 495
+S
Sbjct: 478 VS 479
>gi|15451916 bone morphogenetic protein receptor type II precursor
[Homo sapiens]
Length = 1038
Score = 194 bits (492), Expect = 2e-49
Identities = 137/422 (32%), Positives = 205/422 (48%), Gaps = 53/422 (12%)
Query: 95 CCYTDYCN-RIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQ 153
CC TD CN P P + E + I V +L ++IV L Y
Sbjct: 117 CCSTDLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSVL--AVLIVALCFGYRM 174
Query: 154 RVYHNRQRLD----MEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVL 209
+Q L ME + E L D + L
Sbjct: 175 LTGDRKQGLHSMNMMEAAASEPSLDLDN-----------------------------LKL 205
Query: 210 QEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADN 269
E+IG+GR+G V++G VAVK+FS +++ E IY+ ++ H+NI FI D
Sbjct: 206 LELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDE 265
Query: 270 KDNGTW-TQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIV-GTQG 327
+ + LV +Y+ +GSL YL+ +T +LA S GLA+LH E+ G
Sbjct: 266 RVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHY 325
Query: 328 KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQ-------RVGTKRY 380
KP I+HRDL S+N+LVK +G C I+D GL++R +T + P + VGT RY
Sbjct: 326 KPAISHRDLNSRNVLVKNDGTCVISDFGLSMR---LTGNRLVRPGEEDNAAISEVGTIRY 382
Query: 381 MAPEVLDETINMKHFDS-FKCADIYALGLVYWEIARRCNS---GGVHEEYQLPYYDLVPS 436
MAPEVL+ +N++ +S K D+YALGL+YWEI RC G EYQ+ + V +
Sbjct: 383 MAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGN 442
Query: 437 DPSIEEMRKVVCDQKLRPNIPNWWQSYE-ALRVMGKMMRECWYANGAARLTALRIKKTLS 495
P+ E+M+ +V +K RP P W+ A+R + + + +CW + ARLTA ++ ++
Sbjct: 443 HPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMA 502
Query: 496 QL 497
+L
Sbjct: 503 EL 504
>gi|10198656 anti-Mullerian hormone receptor, type II [Homo sapiens]
Length = 573
Score = 173 bits (438), Expect = 4e-43
Identities = 129/424 (30%), Positives = 205/424 (48%), Gaps = 40/424 (9%)
Query: 93 THCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYH 152
T C TD+CN +P P P GP G +L + +++ L++
Sbjct: 108 TCSCGTDFCNANYSHLPPPG--SPGTPGSQGPQAAPGESIWMALVLLGLFLLLLLLLG-- 163
Query: 153 QRVYHNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEI 212
S + L + K + + SG V+ + ++
Sbjct: 164 ---------------SIILALLQRKNYRVRGEPVPEPRPDSGRDWSVELQELPELCFSQV 208
Query: 213 IGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDN 272
I +G VW G+ +G VA+K F R + E +Y+ L+H++I+ FI A
Sbjct: 209 IREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQHDHIVRFITASRGGP 268
Query: 273 GTWTQ-LWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEI-VGTQGKPG 330
G LV + H GSL YL +YT +++ALS A GLA LH E Q KPG
Sbjct: 269 GRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQNGQYKPG 328
Query: 331 IAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQ--------RVGTKRYMA 382
IAHRDL S+N+L++++G CAI DLGLA+ +T P Q GT+RYMA
Sbjct: 329 IAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAIMEAGTQRYMA 388
Query: 383 PEVLDETINMKHFD-SFKCADIYALGLVYWEIARRC---NSGGVHEEYQLPYYDLVPSDP 438
PE+LD+T++++ + + + ADIY+L L+ WEI RC +QL Y + + P
Sbjct: 389 PELLDKTLDLQDWGMALRRADIYSLALLLWEILSRCPDLRPDSSPPPFQLAYEAELGNTP 448
Query: 439 SIEEMRKVVCDQKLRPNIPNWWQSY----EALRVMGKMMRECWYANGAARLTALRIKKTL 494
+ +E+ + ++ RP IP+ W+ + + LR +++ +CW A+ ARLTA +++ L
Sbjct: 449 TSDELWALAVQERRRPYIPSTWRCFATDPDGLR---ELLEDCWDADPEARLTAECVQQRL 505
Query: 495 SQLS 498
+ L+
Sbjct: 506 AALA 509
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 92.0 bits (227), Expect = 1e-18
Identities = 79/300 (26%), Positives = 137/300 (45%), Gaps = 48/300 (16%)
Query: 205 RTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGF 264
+ + L + IGKG FG+V G +RG VAVK + F AE LRH N++
Sbjct: 193 KELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFL-AEASVMTQLRHSNLVQL 251
Query: 265 IAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEG---MIKLALSAASGLAHLHME 321
+ ++ G L++V++Y GSL DYL ++ G ++K +L + +L
Sbjct: 252 LGVIVEEKG---GLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308
Query: 322 IVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYM 381
HRDL ++N+LV ++ + ++D GL + DT + ++
Sbjct: 309 --------NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL-------PVKWT 353
Query: 382 APEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIE 441
APE L E K F + +D+++ G++ WEI S G ++P D+V P +E
Sbjct: 354 APEALRE----KKFST--KSDVWSFGILLWEI----YSFGRVPYPRIPLKDVV---PRVE 400
Query: 442 EMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQE 501
+ K+ P + YE +M+ CW+ + A R + L++++ L + E
Sbjct: 401 KGYKMDAPDGCPPAV------YE-------VMKNCWHLDAAMRPSFLQLREQLEHIKTHE 447
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 92.0 bits (227), Expect = 1e-18
Identities = 79/300 (26%), Positives = 137/300 (45%), Gaps = 48/300 (16%)
Query: 205 RTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGF 264
+ + L + IGKG FG+V G +RG VAVK + F AE LRH N++
Sbjct: 193 KELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFL-AEASVMTQLRHSNLVQL 251
Query: 265 IAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEG---MIKLALSAASGLAHLHME 321
+ ++ G L++V++Y GSL DYL ++ G ++K +L + +L
Sbjct: 252 LGVIVEEKG---GLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308
Query: 322 IVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYM 381
HRDL ++N+LV ++ + ++D GL + DT + ++
Sbjct: 309 --------NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL-------PVKWT 353
Query: 382 APEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIE 441
APE L E K F + +D+++ G++ WEI S G ++P D+V P +E
Sbjct: 354 APEALRE----KKFST--KSDVWSFGILLWEI----YSFGRVPYPRIPLKDVV---PRVE 400
Query: 442 EMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQE 501
+ K+ P + YE +M+ CW+ + A R + L++++ L + E
Sbjct: 401 KGYKMDAPDGCPPAV------YE-------VMKNCWHLDAAMRPSFLQLREQLEHIKTHE 447
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 85.9 bits (211), Expect = 8e-17
Identities = 81/295 (27%), Positives = 134/295 (45%), Gaps = 57/295 (19%)
Query: 211 EIIGKGRFGEVWRGRWRGGD--VAVKIFSSREERSWFREAEIYQTVMLRHENILGF--IA 266
E G G FG V+R +W D VAVK E +EAEI +L H NI+ F +
Sbjct: 20 ENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE-----KEAEILS--VLSHRNIIQFYGVI 72
Query: 267 ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYT---VTIEGMIKLALSAASGLAHLHMEIV 323
+ + G +V++Y GSL+DY+N + ++ ++ A A G+ +LHME
Sbjct: 73 LEPPNYG------IVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHME-- 124
Query: 324 GTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAP 383
+ HRDLKS+N+++ +G+ I D G + H+ T VGT +MAP
Sbjct: 125 ---APVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHM------SLVGTFPWMAP 175
Query: 384 EVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEM 443
EV+ + + D Y+ G+V WE+ R ++P+ L ++
Sbjct: 176 EVI------QSLPVSETCDTYSYGVVLWEMLTR----------EVPFKGLEGL-----QV 214
Query: 444 RKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLS 498
+V ++ R IP+ R +++ +CW A+ R + +I L +S
Sbjct: 215 AWLVVEKNERLTIPS-----SCPRSFAELLHQCWEADAKKRPSFKQIISILESMS 264
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 85.9 bits (211), Expect = 8e-17
Identities = 81/295 (27%), Positives = 134/295 (45%), Gaps = 57/295 (19%)
Query: 211 EIIGKGRFGEVWRGRWRGGD--VAVKIFSSREERSWFREAEIYQTVMLRHENILGF--IA 266
E G G FG V+R +W D VAVK E +EAEI +L H NI+ F +
Sbjct: 20 ENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE-----KEAEILS--VLSHRNIIQFYGVI 72
Query: 267 ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYT---VTIEGMIKLALSAASGLAHLHMEIV 323
+ + G +V++Y GSL+DY+N + ++ ++ A A G+ +LHME
Sbjct: 73 LEPPNYG------IVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHME-- 124
Query: 324 GTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAP 383
+ HRDLKS+N+++ +G+ I D G + H+ T VGT +MAP
Sbjct: 125 ---APVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHM------SLVGTFPWMAP 175
Query: 384 EVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEM 443
EV+ + + D Y+ G+V WE+ R ++P+ L ++
Sbjct: 176 EVI------QSLPVSETCDTYSYGVVLWEMLTR----------EVPFKGLEGL-----QV 214
Query: 444 RKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLS 498
+V ++ R IP+ R +++ +CW A+ R + +I L +S
Sbjct: 215 AWLVVEKNERLTIPS-----SCPRSFAELLHQCWEADAKKRPSFKQIISILESMS 264
>gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Homo
sapiens]
Length = 648
Score = 82.4 bits (202), Expect = 9e-16
Identities = 70/217 (32%), Positives = 107/217 (49%), Gaps = 28/217 (12%)
Query: 204 ARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFS----SREERSWFREAEIYQTVMLRHE 259
A ++L IG G FG V++G+W GDVAVKI + E+ FR E+ RH
Sbjct: 346 ASEVMLSTRIGSGSFGTVYKGKWH-GDVAVKILKVVDPTPEQFQAFRN-EVAVLRKTRHV 403
Query: 260 NILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIE--GMIKLALSAASGLAH 317
NIL F+ KDN L +V+ + E SL+ +L+ + +I +A A G+ +
Sbjct: 404 NILLFMGYMTKDN-----LAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDY 458
Query: 318 LHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGT 377
LH + I HRD+KS NI + + I D GLA + + + Q G+
Sbjct: 459 LHAK--------NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQV--EQPTGS 508
Query: 378 KRYMAPEVLDETINMKHFDSFKC-ADIYALGLVYWEI 413
+MAPEV I M+ + F +D+Y+ G+V +E+
Sbjct: 509 VLWMAPEV----IRMQDNNPFSFQSDVYSYGIVLYEL 541
>gi|21735566 mitogen-activated protein kinase kinase kinase 7
isoform D [Homo sapiens]
Length = 491
Score = 80.5 bits (197), Expect = 3e-15
Identities = 64/217 (29%), Positives = 100/217 (46%), Gaps = 30/217 (13%)
Query: 205 RTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGF 264
+ I ++E++G+G FG V + +WR DVA+K S ER F E+ Q + H NI+
Sbjct: 34 KEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAF-IVELRQLSRVNHPNIVKL 92
Query: 265 IAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYT----VTIEGMIKLALSAASGLAHLHM 320
A + LV +Y E GSL++ L+ T + L + G+A+LH
Sbjct: 93 YGA------CLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH- 145
Query: 321 EIVGTQGKPGIAHRDLKSKNILVKKNG-MCAIADLGLAVRHDAVTDTIDIAPNQRVGTKR 379
+ + HRDLK N+L+ G + I D G A I G+
Sbjct: 146 ----SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-------DIQTHMTNNKGSAA 194
Query: 380 YMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARR 416
+MAPEV + + S KC D+++ G++ WE+ R
Sbjct: 195 WMAPEVFEGSNY-----SEKC-DVFSWGIILWEVITR 225
>gi|21735564 mitogen-activated protein kinase kinase kinase 7
isoform C [Homo sapiens]
Length = 518
Score = 80.5 bits (197), Expect = 3e-15
Identities = 64/217 (29%), Positives = 100/217 (46%), Gaps = 30/217 (13%)
Query: 205 RTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGF 264
+ I ++E++G+G FG V + +WR DVA+K S ER F E+ Q + H NI+
Sbjct: 34 KEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAF-IVELRQLSRVNHPNIVKL 92
Query: 265 IAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYT----VTIEGMIKLALSAASGLAHLHM 320
A + LV +Y E GSL++ L+ T + L + G+A+LH
Sbjct: 93 YGA------CLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH- 145
Query: 321 EIVGTQGKPGIAHRDLKSKNILVKKNG-MCAIADLGLAVRHDAVTDTIDIAPNQRVGTKR 379
+ + HRDLK N+L+ G + I D G A I G+
Sbjct: 146 ----SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-------DIQTHMTNNKGSAA 194
Query: 380 YMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARR 416
+MAPEV + + S KC D+++ G++ WE+ R
Sbjct: 195 WMAPEVFEGSNY-----SEKC-DVFSWGIILWEVITR 225
>gi|21735562 mitogen-activated protein kinase kinase kinase 7
isoform B [Homo sapiens]
Length = 606
Score = 80.5 bits (197), Expect = 3e-15
Identities = 64/217 (29%), Positives = 100/217 (46%), Gaps = 30/217 (13%)
Query: 205 RTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGF 264
+ I ++E++G+G FG V + +WR DVA+K S ER F E+ Q + H NI+
Sbjct: 34 KEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAF-IVELRQLSRVNHPNIVKL 92
Query: 265 IAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYT----VTIEGMIKLALSAASGLAHLHM 320
A + LV +Y E GSL++ L+ T + L + G+A+LH
Sbjct: 93 YGA------CLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH- 145
Query: 321 EIVGTQGKPGIAHRDLKSKNILVKKNG-MCAIADLGLAVRHDAVTDTIDIAPNQRVGTKR 379
+ + HRDLK N+L+ G + I D G A I G+
Sbjct: 146 ----SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-------DIQTHMTNNKGSAA 194
Query: 380 YMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARR 416
+MAPEV + + S KC D+++ G++ WE+ R
Sbjct: 195 WMAPEVFEGSNY-----SEKC-DVFSWGIILWEVITR 225
>gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform
A [Homo sapiens]
Length = 579
Score = 80.5 bits (197), Expect = 3e-15
Identities = 64/217 (29%), Positives = 100/217 (46%), Gaps = 30/217 (13%)
Query: 205 RTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGF 264
+ I ++E++G+G FG V + +WR DVA+K S ER F E+ Q + H NI+
Sbjct: 34 KEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAF-IVELRQLSRVNHPNIVKL 92
Query: 265 IAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYT----VTIEGMIKLALSAASGLAHLHM 320
A + LV +Y E GSL++ L+ T + L + G+A+LH
Sbjct: 93 YGA------CLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH- 145
Query: 321 EIVGTQGKPGIAHRDLKSKNILVKKNG-MCAIADLGLAVRHDAVTDTIDIAPNQRVGTKR 379
+ + HRDLK N+L+ G + I D G A I G+
Sbjct: 146 ----SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-------DIQTHMTNNKGSAA 194
Query: 380 YMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARR 416
+MAPEV + + S KC D+++ G++ WE+ R
Sbjct: 195 WMAPEVFEGSNY-----SEKC-DVFSWGIILWEVITR 225
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.433
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,508,879
Number of Sequences: 37866
Number of extensions: 880031
Number of successful extensions: 3392
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 360
Number of HSP's successfully gapped in prelim test: 360
Number of HSP's that attempted gapping in prelim test: 2263
Number of HSP's gapped (non-prelim): 818
length of query: 505
length of database: 18,247,518
effective HSP length: 107
effective length of query: 398
effective length of database: 14,195,856
effective search space: 5649950688
effective search space used: 5649950688
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.