Search of human proteins with 4557461

Search of human proteins with 4557461

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4557461 nicotinic acetylcholine receptor delta polypeptide
precursor [Homo sapiens]
         (517 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4557461 nicotinic acetylcholine receptor delta polypeptide pr...  1045   0.0  
gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide p...   450   e-126
gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide ...   423   e-118
gi|4502833 neuronal nicotinic acetylcholine receptor beta 2 prec...   381   e-106
gi|41327726 nicotinic acetylcholine receptor beta 1 subunit prec...   366   e-101
gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]     356   2e-98
gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]   339   4e-93
gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]    332   5e-91
gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide ...   330   2e-90
gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3 [...   300   2e-81
gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b prec...   298   6e-81
gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit prec...   296   2e-80
gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]   289   5e-78
gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a pre...   288   1e-77
gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [H...   251   9e-67
gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor [...   244   2e-64
gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo sapi...   232   5e-61
gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]              180   3e-45
gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform...   176   5e-44
gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform...   176   5e-44
gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform...   170   3e-42
gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]              133   3e-31
gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]   132   8e-31
gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]   132   1e-30
gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor...   129   6e-30
gi|157389018 gamma-aminobutyric acid A receptor, alpha 6 precurs...    70   5e-12
gi|34452723 gamma-aminobutyric acid A receptor, alpha 4 precurso...    68   2e-11
gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3 ...    66   7e-11
gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform ...    66   9e-11
gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform ...    66   9e-11

>gi|4557461 nicotinic acetylcholine receptor delta polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score = 1045 bits (2702), Expect = 0.0
 Identities = 517/517 (100%), Positives = 517/517 (100%)

Query: 1   MEGPVLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTL 60
           MEGPVLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTL
Sbjct: 1   MEGPVLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTL 60

Query: 61  SNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNND 120
           SNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNND
Sbjct: 61  SNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNND 120

Query: 121 GSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEIT 180
           GSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEIT
Sbjct: 121 GSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEIT 180

Query: 181 LSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYL 240
           LSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYL
Sbjct: 181 LSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYL 240

Query: 241 IIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLP 300
           IIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLP
Sbjct: 241 IIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLP 300

Query: 301 ATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLH 360
           ATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLH
Sbjct: 301 ATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLH 360

Query: 361 MSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRP 420
           MSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRP
Sbjct: 361 MSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRP 420

Query: 421 PASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPV 480
           PASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPV
Sbjct: 421 PASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPV 480

Query: 481 MVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI 517
           MVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI
Sbjct: 481 MVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI 517


>gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  450 bits (1157), Expect = e-126
 Identities = 246/524 (46%), Positives = 331/524 (63%), Gaps = 32/524 (6%)

Query: 2   EGPVLTLGLLAALAVC-GSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTL 60
           +GP+L   LL  LAVC G+ G N+EERL+  L Q   Y+  LRP     + V+V+L LTL
Sbjct: 5   QGPLL---LLLLLAVCLGAQGRNQEERLLADLMQN--YDPNLRPAERDSDVVNVSLKLTL 59

Query: 61  SNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNND 120
           +NLISL E EE LTTNVWIE  W D RL+W+  ++  + VLR+P  MVW P+IVLENN D
Sbjct: 60  TNLISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVD 119

Query: 121 GSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEIT 180
           G F+++  CNVLV   G +YWLPPAIFRS+C ISVTYFPFDWQNCSL F S  Y+  EI 
Sbjct: 120 GVFEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEID 179

Query: 181 LSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYL 240
           L L Q+  +     +EWI IDPE FTENGEW I HRPA++ +DP AP      Q + FYL
Sbjct: 180 LQLSQEDGQT----IEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYL 235

Query: 241 IIRRKPLFYIINILVPCVLISFMVNLVFYLPADS-GEKTSVAISVLLAQSVFLLLISKRL 299
           +I+RKPLFY+INI+ PCVLIS +  L+ +LPA + G+K +VAI+VLLAQ+VFL L++K++
Sbjct: 236 LIQRKPLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKV 295

Query: 300 PATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELL 359
           P TS A+PLI K+L F +V+  ++VV  V+VLN+  R+P TH ++ GV+K+FL  LP+LL
Sbjct: 296 PETSQAVPLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLL 355

Query: 360 HMS-RPAEDGPSPGAL------VRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLAR 412
            M  RP     +P A+      ++  SS   I+  EE  L   RS+L+F++   +  +A 
Sbjct: 356 RMHVRPL----APAAVQDTQSRLQNGSSGWSITTGEEVALCLPRSELLFQQWQRQGLVAA 411

Query: 413 RLTTARRPPASSEQAQQELFNELKPA-------VDGANFIVNHMRDQNNYNEEKDSWNRV 465
            L    + P   E    +    LK A       V+  N I      Q++++   + W  V
Sbjct: 412 ALEKLEKGP---ELGLSQFCGSLKQAAPAIQACVEACNLIACARHQQSHFDNGNEEWFLV 468

Query: 466 ARTVDRLCLFVVTPVMVVGTAWIFLQGVYNQPPPQPFPGDPYSY 509
            R +DR+C   +  + + GTA IFL   YN+ P  PFPGDP  Y
Sbjct: 469 GRVLDRVCFLAMLSLFICGTAGIFLMAHYNRVPALPFPGDPRPY 512


>gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide
           precursor [Homo sapiens]
          Length = 493

 Score =  423 bits (1087), Expect = e-118
 Identities = 229/497 (46%), Positives = 313/497 (62%), Gaps = 17/497 (3%)

Query: 8   LGLLAALAVCGSW-GLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISL 66
           LG+L  L + G   G NEE RL  HLF    Y+   RPV   E++V ++L +TL+NLISL
Sbjct: 6   LGVLLLLGLLGRGVGKNEELRLYHHLFNN--YDPGSRPVREPEDTVTISLKVTLTNLISL 63

Query: 67  KEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQIS 126
            E EETLTT+VWI   W D RL ++ ++FG I  LR+P ++VWLPEIVLENN DG F ++
Sbjct: 64  NEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVA 123

Query: 127 YSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQD 186
           Y  NVLVY  G V WLPPAI+RS C + VTYFPFDWQNCSL F S  Y A+E+  +    
Sbjct: 124 YDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTF--- 180

Query: 187 AKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKP 246
           A +N    +  I ID E +TENGEW I   P  +        D P   D+ + LIIRRKP
Sbjct: 181 AVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKP 240

Query: 247 LFYIINILVPCVLISFMVNLVFYLPADS-GEKTSVAISVLLAQSVFLLLISKRLPATSMA 305
           LFY+INI+VPCVLIS +V L ++LPA + G+K +V+I+VLLAQ+VFL LI++++P TS++
Sbjct: 241 LFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLS 300

Query: 306 IPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPA 365
           +PL+G+FL+F MV+ T++V+ CVIVLN+  RTP+TH +S  ++ + LE LP LL  S P 
Sbjct: 301 VPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLG-SPPP 359

Query: 366 EDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRPPASSE 425
            + P   +  RR+SS+G + +AEE  L K RS+L+FE Q  R G            A+  
Sbjct: 360 PEAPRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTW---------TAAFC 410

Query: 426 QAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGT 485
           Q+      E++  VD  NF+    RDQ    EE   W R+   +D +C +    +  VG+
Sbjct: 411 QSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGS 470

Query: 486 AWIFLQGVYNQPPPQPF 502
           + IFL   +N+ P  P+
Sbjct: 471 SLIFLGAYFNRVPDLPY 487


>gi|4502833 neuronal nicotinic acetylcholine receptor beta 2
           precursor [Homo sapiens]
          Length = 502

 Score =  381 bits (978), Expect = e-106
 Identities = 211/496 (42%), Positives = 293/496 (59%), Gaps = 22/496 (4%)

Query: 3   GPVLTLGLLAALAVC-GSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLS 61
           GPV  L     L +C G WG + EERL+ HL     YNK +RP  +  E V V L ++L+
Sbjct: 6   GPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLA 65

Query: 62  NLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDG 121
            LIS+ E E+ +TTNVW+   W D RL W  EEF N+  +RLP   +WLP++VL NN DG
Sbjct: 66  QLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADG 125

Query: 122 SFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITL 181
            +++S+  N +V + G ++WLPPAI++S+C I V +FPFD QNC++KF S  Y   EI L
Sbjct: 126 MYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDL 185

Query: 182 SLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLI 241
            LK +            +   + FT +GEW+IV  P R N +P    D  +  DIT+  I
Sbjct: 186 VLKSE------------VASLDDFTPSGEWDIVALPGRRNENP----DDSTYVDITYDFI 229

Query: 242 IRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPA 301
           IRRKPLFY IN+++PCVLI+ +  LVFYLP+D GEK ++ ISVLLA +VFLLLISK +P 
Sbjct: 230 IRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPP 289

Query: 302 TSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHM 361
           TS+ +PL+GK+L+F MVLVT  +V  V VLN+H R+P+TH ++  VK +FLE LP LL M
Sbjct: 290 TSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFM 349

Query: 362 SRPAEDGPSPGALVRRSSSLGYISKAEEYFLLK---SRSDLMFEKQSERHGLARRLTTAR 418
            +P          +RR         A   F  +   + S   F  ++   GLA       
Sbjct: 350 QQPRHHCARQRLRLRRRQR--EREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEP 407

Query: 419 RPPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVT 478
            P A   ++ +     L+ AVDG  FI +HMR +++     + W  VA  +DRL L++  
Sbjct: 408 APVAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFV 467

Query: 479 PVMVVGTAWIFLQGVY 494
            V V GT  +FLQ ++
Sbjct: 468 FVCVFGTIGMFLQPLF 483


>gi|41327726 nicotinic acetylcholine receptor beta 1 subunit
           precursor [Homo sapiens]
          Length = 501

 Score =  366 bits (940), Expect = e-101
 Identities = 205/504 (40%), Positives = 295/504 (58%), Gaps = 14/504 (2%)

Query: 5   VLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLI 64
           ++ LG L A    G  G   E RL   LF   GY+  +RP     + V V++ L L+ LI
Sbjct: 7   LMLLGALGAPLAPGVRGSEAEGRLREKLFS--GYDSSVRPAREVGDRVRVSVGLILAQLI 64

Query: 65  SLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQ 124
           SL E +E ++T V+++  WTD RL W+  E   I  LR+  + VWLP++VL NNNDG+F 
Sbjct: 65  SLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFD 124

Query: 125 ISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITL--S 182
           ++   +V+V   G V W PP I+RSSC I VTYFPFDWQNC++ FSS  Y + E++L   
Sbjct: 125 VALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTG 184

Query: 183 LKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLD--SPSRQDITFYL 240
           L  D + ++      I I    F ENG+WEI+H+P+R+   P  P       RQ++ FYL
Sbjct: 185 LGPDGQGHQE-----IHIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYL 239

Query: 241 IIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLP 300
           IIRRKPLFY++N++ PC+LI+ +   VFYLP D+GEK  ++I  LL  +VFLLL++ ++P
Sbjct: 240 IIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVP 299

Query: 301 ATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLH 360
            TS+++P+I K+L+F MVLVT  V++ V+VLN+H R+P TH +   V+++F+  LP  L 
Sbjct: 300 ETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLR 359

Query: 361 MSRP-AEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARR 419
           + RP  E    P      S   G+    +EYF+ K  SD +F K + R          RR
Sbjct: 360 LKRPKPERDLMPEPPHCSSPGSGWGRGTDEYFIRKPPSDFLFPKPN-RFQPELSAPDLRR 418

Query: 420 PPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTP 479
                 +A   L  EL+  V   ++I   +++Q +++  K+ W  VA  VDRL L+    
Sbjct: 419 FIDGPNRA-VALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFII 477

Query: 480 VMVVGTAWIFLQGVYNQPPPQPFP 503
              VGT  IFL   Y+ PPP PFP
Sbjct: 478 FTSVGTLVIFLDATYHLPPPDPFP 501


>gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]
          Length = 498

 Score =  356 bits (914), Expect = 2e-98
 Identities = 202/502 (40%), Positives = 287/502 (57%), Gaps = 34/502 (6%)

Query: 4   PVLTLGLLAALAVCGSWGL-NEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSN 62
           P L L  L AL   G+  + N EE+L+  L  +  YN  +RP     + + + L L+L+ 
Sbjct: 5   PSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQ 64

Query: 63  LISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGS 122
           LIS+ E E+ +TTNVW++  WTD RL WN+  +  +++LR+P   +WLP+IVL NN DG+
Sbjct: 65  LISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGT 124

Query: 123 FQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLS 182
           +++S   N++V   G V WLPPAI++S+C I V YFPFD QNC+LKF S  Y   EI + 
Sbjct: 125 YEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMV 184

Query: 183 LKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLII 242
           L                   + FT +GEW+IV  P R  V+P+     PS  D+T+  II
Sbjct: 185 LMTPT------------ASMDDFTPSGEWDIVALPGRRTVNPQ----DPSYVDVTYDFII 228

Query: 243 RRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPAT 302
           +RKPLFY IN+++PCVL + +  LVFYLP+D GEK ++ ISVLLA + FLLLISK +P T
Sbjct: 229 KRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPT 288

Query: 303 SMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMS 362
           S+ +PLIGK+L+F MVLVT  +V  V VLN+H R+PSTH ++  VK+ FL  LP  L M 
Sbjct: 289 SLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMK 348

Query: 363 RPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRPPA 422
           RP  D  SP      S S   ++K E      S S+                + A + PA
Sbjct: 349 RPGPDS-SPARAFPPSKSC--VTKPEATATSTSPSNFYGNSMY----FVNPASAASKSPA 401

Query: 423 SSE----------QAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRL 472
            S           ++      +++ A++G +FI  HM++ +      + W  VA  VDRL
Sbjct: 402 GSTPVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRL 461

Query: 473 CLFVVTPVMVVGTAWIFLQGVY 494
            L+V   V V+GT  +FL  ++
Sbjct: 462 FLWVFMFVCVLGTVGLFLPPLF 483


>gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]
          Length = 505

 Score =  339 bits (869), Expect = 4e-93
 Identities = 195/502 (38%), Positives = 288/502 (57%), Gaps = 36/502 (7%)

Query: 5   VLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLI 64
           +L L LL+ L V  +     E RL   LF++  YN+ +RPVA+  + V +   +++S L+
Sbjct: 17  LLLLLLLSLLPVARA--SEAEHRLFERLFED--YNEIIRPVANVSDPVIIHFEVSMSQLV 72

Query: 65  SLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQ 124
            + EV + + TN+W++  W D +LKWN  ++G    +R+P   +W P+IVL NN  G FQ
Sbjct: 73  KVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQ 132

Query: 125 ISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLK 184
           +      L+ + G V W+PPAIF+SSC I VTYFPFD+QNC++KF S  Y   +I L L 
Sbjct: 133 VDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLI 192

Query: 185 QDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRR 244
             +   + Y   W         E+GEW I+  P   + D +         DIT+ L IRR
Sbjct: 193 GSSMNLKDY---W---------ESGEWAIIKAPGYKH-DIKYNCCEEIYPDITYSLYIRR 239

Query: 245 KPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSM 304
            PLFY IN+++PC+LISF+  LVFYLP+D GEK ++ ISVLL+ +VFLL+I++ +P+TS+
Sbjct: 240 LPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSL 299

Query: 305 AIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRP 364
            IPLIG++LLF M+ VT+ +VI V VLN+H+RTP+TH +   VK +FL  LP ++ M+RP
Sbjct: 300 VIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRP 359

Query: 365 AE---DGPSPGALV-RRSSSLGYISKAEE------YFLLKSRSDLMFEKQSERHGLARRL 414
                +   P  L     S+L   S+AE       Y            ++ +    +  L
Sbjct: 360 TSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANL 419

Query: 415 TTARRPPASSEQAQ-----QELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTV 469
           T +    +SSE          L  E+K A+    +I  +M+ QN   E +D W  VA  +
Sbjct: 420 TRS----SSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVI 475

Query: 470 DRLCLFVVTPVMVVGTAWIFLQ 491
           DR+ L+V T V ++GTA +FLQ
Sbjct: 476 DRIFLWVFTLVCILGTAGLFLQ 497


>gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]
          Length = 494

 Score =  332 bits (851), Expect = 5e-91
 Identities = 186/480 (38%), Positives = 267/480 (55%), Gaps = 27/480 (5%)

Query: 18  GSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNV 77
           G  G   EERL   LF    YN+ +RPV +  + V V   + ++ L ++ EV + + TN+
Sbjct: 27  GCVGCATEERLFHKLFSH--YNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNL 84

Query: 78  WIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYG 137
           W+ H W D +L+W+  E+  I  LR+P D +W P+IVL NN  G FQ+      L+ + G
Sbjct: 85  WLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNG 144

Query: 138 FVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEW 197
            + W PPAIF+SSCP+ +T+FPFD QNCSLKF S  Y   EI L +              
Sbjct: 145 MITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSK---------- 194

Query: 198 IIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPC 257
             +D   F EN EWEI+      + D +         DIT+   IRR P+FY IN+++PC
Sbjct: 195 --VDMNDFWENSEWEIIDASGYKH-DIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPC 251

Query: 258 VLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGM 317
           + ISF+  LVFYLP+D GEK ++ ISVLL+ +VFLL+I++ +P+TS+ +PL+G++LLF M
Sbjct: 252 LFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTM 311

Query: 318 VLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAE------DGPSP 371
           + VT+ +V+ V VLNIH+RTP+TH +   VK +FL+ LP++L M  P +          P
Sbjct: 312 IFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVP 371

Query: 372 GALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRPPASSEQAQQEL 431
             L RR +     S  E   L   +      K +E     RRL+     P        E 
Sbjct: 372 RGLARRPAKGKLASHGEPRHL---KECFHCHKSNELATSKRRLS---HQPLQWVVENSEH 425

Query: 432 FNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIFLQ 491
             E++  ++   FI  +M+  N   E +D W  VA  VDR+ L+V   V V GTA +FLQ
Sbjct: 426 SPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFLQ 485


>gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide 2
           (neuronal) [Homo sapiens]
          Length = 529

 Score =  330 bits (845), Expect = 2e-90
 Identities = 179/486 (36%), Positives = 282/486 (58%), Gaps = 43/486 (8%)

Query: 25  EERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWT 84
           E+RL +HLF  +GYN+  RPV +  + V V   L+++ LI + E  + +TTNVW++  W+
Sbjct: 59  EDRLFKHLF--RGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWS 116

Query: 85  DNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPP 144
           D +L+WN  +FGNI+ LR+P +M+W+P+IVL NN DG F +++     ++  G V+W+PP
Sbjct: 117 DYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPP 176

Query: 145 AIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEG 204
           AI++SSC I VT+FPFD QNC +KF S  Y   +I L   +              +D + 
Sbjct: 177 AIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQT------------VDLKD 224

Query: 205 FTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMV 264
           + E+GEW IV+     N   +    +    D+T+  +IRR PLFY IN+++PC+LIS + 
Sbjct: 225 YWESGEWAIVNATGTYN-SKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLT 283

Query: 265 NLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVV 324
            LVFYLP+D GEK ++ ISVLL+ +VFLLLI++ +P+TS+ IPLIG++LLF M+ VT+ +
Sbjct: 284 VLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSI 343

Query: 325 VICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPSPGALVRRSSSLGYI 384
           VI V VLN+H R+PSTH +   V+   L  +P  L M+RP    P P  L         +
Sbjct: 344 VITVFVLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRP----PPPVELCHPLR----L 395

Query: 385 SKAEEYFLLKSRSD-----LMFEKQSE---------------RHGLARRLTTARRPPASS 424
             +  Y  L+S  D     ++ E++                  HG      +  +  A  
Sbjct: 396 KLSPSYHWLESNVDAEEREVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALL 455

Query: 425 EQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVG 484
           ++ +  L   ++ A++G ++I +H+R ++  +  K+ W  VA  +DR+ L++   V  +G
Sbjct: 456 QEGELLLSPHMQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLG 515

Query: 485 TAWIFL 490
           T  +FL
Sbjct: 516 TIGLFL 521


>gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3
           [Homo sapiens]
          Length = 458

 Score =  300 bits (769), Expect = 2e-81
 Identities = 168/466 (36%), Positives = 266/466 (57%), Gaps = 49/466 (10%)

Query: 25  EERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWT 84
           E+ L+RHLFQ  GY K +RPV H  +++ V   L +S L+ + E  + +TTNVW++  WT
Sbjct: 29  EDALLRHLFQ--GYQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEWT 86

Query: 85  DNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPP 144
           D++L+WN +++G I  +++P + +WLP+IVL  N DG F+ S    V+V   G V W PP
Sbjct: 87  DHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGTVVWTPP 146

Query: 145 AIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEG 204
           A ++SSC + VT+FPFD QNCS+KF S  Y    + L L     EN         +D + 
Sbjct: 147 ASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLIL---INEN---------VDRKD 194

Query: 205 FTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMV 264
           F +NGEWEI++               P    IT+  ++RR PLFY + +++PC+ +SF+ 
Sbjct: 195 FFDNGEWEILNAKGMKGNRRDGVYSYPF---ITYSFVLRRLPLFYTLFLIIPCLGLSFLT 251

Query: 265 NLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVV 324
            LVFYLP+D GEK S++ SVL++ +VFLL+I + +P++S  IPLIG++LLF M+ VT+ +
Sbjct: 252 VLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSI 311

Query: 325 VICVIVLNIHFRTPST-HVLSEGVKKLFLETLPELLHMSRPAEDGPSPGALVRRSSSLGY 383
           ++ V V+N+H R+ ST H ++  VK+LFL+ LP+LL M    +   SP            
Sbjct: 312 IVTVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSP------------ 359

Query: 384 ISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRPPASSEQAQQELFNELKPAVDGAN 443
             K E   ++K +   + EK+ ++                    ++ L   L+ A D   
Sbjct: 360 -EKEESQPVVKGK---VLEKKKQK---------------QLSDGEKVLVAFLEKAADSIR 400

Query: 444 FIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIF 489
           +I  H++ ++  ++    W  VA+ +DR+ L++   V V G+  IF
Sbjct: 401 YISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLIVSVTGSVLIF 446


>gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b
           precursor [Homo sapiens]
          Length = 457

 Score =  298 bits (764), Expect = 6e-81
 Identities = 171/487 (35%), Positives = 266/487 (54%), Gaps = 53/487 (10%)

Query: 10  LLAALAVCGSW---GLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISL 66
           LL   ++C +    G   E RL+  LF  K Y+  +RPV    + V+V + L L  LI++
Sbjct: 6   LLLLFSLCSAGLVLGSEHETRLVAKLF--KDYSSVVRPVEDHRQVVEVTVGLQLIQLINV 63

Query: 67  KEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQIS 126
            EV + +TTNV ++  W D  LKWN +++G +  + +P + +W P++VL NN DG F I 
Sbjct: 64  DEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIV 123

Query: 127 YSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQD 186
               VL+ + G + W PPAIF+S C I VT+FPFD QNCS+K  +  Y    + ++ + D
Sbjct: 124 KFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESD 183

Query: 187 AKENRTYPVEWIIIDPEGFTENGEWEIVH-RPARVNVDPRAPLDSPSRQDITFYLIIRRK 245
                         D   F E+GEW I   R  + +V      D+P   DIT++ +++R 
Sbjct: 184 QP------------DLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYL-DITYHFVMQRL 230

Query: 246 PLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMA 305
           PL++I+N+++PC+L SF+  LVFYLP DSGEK +++ISVLL+ +VFLL+I + +P+TS A
Sbjct: 231 PLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSA 290

Query: 306 IPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLH---MS 362
           +PLIGK++LF MV V   ++I VIV+N H R+PSTHV+   V+K+F++T+P ++    M 
Sbjct: 291 VPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMK 350

Query: 363 RPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRPPA 422
           RP+ +                  + ++ F      D+     S + G          PP 
Sbjct: 351 RPSRE-----------------KQDKKIF----TEDIDISDISGKPG----------PPP 379

Query: 423 SSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMV 482
               +      E+K A++G  +I   M+     N     W  VA  +D + L V   V +
Sbjct: 380 MGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCI 439

Query: 483 VGTAWIF 489
           +GT  +F
Sbjct: 440 IGTLAVF 446


>gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit
           precursor [Homo sapiens]
          Length = 627

 Score =  296 bits (759), Expect = 2e-80
 Identities = 149/341 (43%), Positives = 221/341 (64%), Gaps = 15/341 (4%)

Query: 25  EERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWT 84
           EERL++ LF   GYNK  RPVA+  + V V   L+++ LI + E  + +TTNVW++  W 
Sbjct: 37  EERLLKKLFS--GYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWH 94

Query: 85  DNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPP 144
           D +L+W+  ++ N++ +R+P +++W P+IVL NN DG F +++     ++H G V W PP
Sbjct: 95  DYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPP 154

Query: 145 AIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEG 204
           AI++SSC I VT+FPFD QNC++KF S  Y   +I L                  +D   
Sbjct: 155 AIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSR------------VDQLD 202

Query: 205 FTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMV 264
           F E+GEW IV      N   +    +    DIT+  +IRR PLFY IN+++PC+LIS + 
Sbjct: 203 FWESGEWVIVDAVGTYNTR-KYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLT 261

Query: 265 NLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVV 324
            LVFYLP++ GEK ++ ISVLL+ +VFLLLI++ +P+TS+ IPLIG++LLF M+ VT+ +
Sbjct: 262 VLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSI 321

Query: 325 VICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPA 365
           VI V VLN+H R+P TH +   V+++FL+ +P LL M RP+
Sbjct: 322 VITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPS 362



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 32/127 (25%), Positives = 54/127 (42%), Gaps = 7/127 (5%)

Query: 364 PAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRPPAS 423
           P  DG + GAL  R++    +   ++    K          S    +  R T A  P   
Sbjct: 500 PEADGQAAGALASRNTHSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLP 559

Query: 424 SEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVV 483
              A       L  AV+G  +I +H++ ++     K+ W  VA  +DR+ L++   V ++
Sbjct: 560 LSPA-------LTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLL 612

Query: 484 GTAWIFL 490
           GT  +FL
Sbjct: 613 GTVGLFL 619


>gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]
          Length = 468

 Score =  289 bits (739), Expect = 5e-78
 Identities = 159/471 (33%), Positives = 258/471 (54%), Gaps = 66/471 (14%)

Query: 25  EERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWT 84
           E+ L++ LFQ+  Y + +RPV H  + + +   L +S L+ + E  + +TTNVW++  W 
Sbjct: 47  EDSLLKDLFQD--YERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWI 104

Query: 85  DNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPP 144
           D +L+WN +++G I V+R+P D VW P+IVL +N DG F+ + +  V+ Y+ G V W PP
Sbjct: 105 DVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYN-GTVTWTPP 163

Query: 145 AIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEG 204
           A ++SSC I VT+FPFD QNCS+KF S  Y   ++ + L+               +D   
Sbjct: 164 ANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQD------------VDKRD 211

Query: 205 FTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMV 264
           F +NGEWEIV           +    P    +T+  +I+R PLFY + +++PC+ +SF+ 
Sbjct: 212 FFDNGEWEIVSATGSKGNRTDSCCWYPY---VTYSFVIKRLPLFYTLFLIIPCIGLSFLT 268

Query: 265 NLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVV 324
            LVFYLP++ GEK  +  SVL++ +VFLL+I + +P++S  IPLIG++L+F M+ VT+ +
Sbjct: 269 VLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSI 328

Query: 325 VICVIVLNIHFRTPSTH-VLSEGVKKLFLETLPELLHMSRPAEDGPSPGALVRRSSSLGY 383
           ++ V  +NIH R+ STH  ++  V+K+FL TLP+LL M                      
Sbjct: 329 MVTVFAINIHHRSSSTHNAMAPLVRKIFLHTLPKLLCMR--------------------- 367

Query: 384 ISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRPPASSEQAQQELFNELKPAVDGAN 443
            S  + YF  K  ++     +S R                         N L+ A+D   
Sbjct: 368 -SHVDRYFTQKEETESGSGPKSSR-------------------------NTLEAALDSIR 401

Query: 444 FIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIFLQGVY 494
           +I  H+  +N+  E  + W  +A+ +DR+ L+    V +VG+  +F+  +Y
Sbjct: 402 YITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFVPVIY 452


>gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a
           precursor [Homo sapiens]
          Length = 482

 Score =  288 bits (736), Expect = 1e-77
 Identities = 172/512 (33%), Positives = 267/512 (52%), Gaps = 78/512 (15%)

Query: 10  LLAALAVCGSW---GLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISL 66
           LL   ++C +    G   E RL+  LF  K Y+  +RPV    + V+V + L L  LI++
Sbjct: 6   LLLLFSLCSAGLVLGSEHETRLVAKLF--KDYSSVVRPVEDHRQVVEVTVGLQLIQLINV 63

Query: 67  KEVEETLTTNVWIEHG-------------------------WTDNRLKWNAEEFGNISVL 101
            EV + +TTNV ++ G                         W D  LKWN +++G +  +
Sbjct: 64  DEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKI 123

Query: 102 RLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFD 161
            +P + +W P++VL NN DG F I     VL+ + G + W PPAIF+S C I VT+FPFD
Sbjct: 124 HIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFD 183

Query: 162 WQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVH-RPARV 220
            QNCS+K  +  Y    + ++ + D              D   F E+GEW I   R  + 
Sbjct: 184 EQNCSMKLGTWTYDGSVVAINPESDQP------------DLSNFMESGEWVIKESRGWKH 231

Query: 221 NVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSV 280
           +V      D+P   DIT++ +++R PL++I+N+++PC+L SF+  LVFYLP DSGEK ++
Sbjct: 232 SVTYSCCPDTPYL-DITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTL 290

Query: 281 AISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPST 340
           +ISVLL+ +VFLL+I + +P+TS A+PLIGK++LF MV V   ++I VIV+N H R+PST
Sbjct: 291 SISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPST 350

Query: 341 HVLSEGVKKLFLETLPELLH---MSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRS 397
           HV+   V+K+F++T+P ++    M RP+ +                  + ++ F      
Sbjct: 351 HVMPNWVRKVFIDTIPNIMFFSTMKRPSRE-----------------KQDKKIF----TE 389

Query: 398 DLMFEKQSERHGLARRLTTARRPPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNE 457
           D+     S + G          PP     +      E+K A++G  +I   M+     N 
Sbjct: 390 DIDISDISGKPG----------PPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNN 439

Query: 458 EKDSWNRVARTVDRLCLFVVTPVMVVGTAWIF 489
               W  VA  +D + L V   V ++GT  +F
Sbjct: 440 AAAEWKYVAMVMDHILLGVFMLVCIIGTLAVF 471


>gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [Homo
           sapiens]
          Length = 502

 Score =  251 bits (642), Expect = 9e-67
 Identities = 156/477 (32%), Positives = 241/477 (50%), Gaps = 31/477 (6%)

Query: 30  RHLFQE--KGYNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWTDNR 87
           R L++E  K YN   RPVA+  + + V  +L+L  ++ + E  + LTTN+W++  WTD+ 
Sbjct: 27  RKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHY 86

Query: 88  LKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPPAIF 147
           L+WN  E+  +  +R P   +W P+I+L N+ D  F  ++  NVLV   G   +LPP IF
Sbjct: 87  LQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIF 146

Query: 148 RSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEGFTE 207
           +SSC I V +FPFD Q+C LKF S  Y    + L +++               D  G+  
Sbjct: 147 KSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQE--------------ADISGYIP 192

Query: 208 NGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLV 267
           NGEW++V  P + +         P   D+TF + +RR+ L+Y +N+L+PCVLIS +  LV
Sbjct: 193 NGEWDLVGIPGKRSERFYECCKEP-YPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLV 251

Query: 268 FYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVIC 327
           F LPADSGEK S+ I+VLL+ +VF+LL+++ +PATS ++PLI ++    M++V + VV+ 
Sbjct: 252 FLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVT 311

Query: 328 VIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPSPGAL-VRRSSSLGYISK 386
           VIVL  H   P    + +  + + L      L M RP ED   P     +R  SL  +  
Sbjct: 312 VIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEM 371

Query: 387 AEEYFLLKSRSDLMFEKQSERHGLARRLT-----TARRPPASSEQAQQELFN-------- 433
           +       S  +L++       G+    T        R   S    +  L          
Sbjct: 372 SAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDP 431

Query: 434 ELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIFL 490
           +L   ++   +I N  R Q+        W   A  VDRLCL   +   ++ T  I +
Sbjct: 432 DLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILM 488


>gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor
           [Homo sapiens]
          Length = 479

 Score =  244 bits (622), Expect = 2e-64
 Identities = 145/463 (31%), Positives = 237/463 (51%), Gaps = 20/463 (4%)

Query: 26  ERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWTD 85
           ++L   LF++  Y+  LRPV   ++ ++V L +TLS +  + E  + LT  +WI   W D
Sbjct: 32  QKLFNDLFED--YSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHD 89

Query: 86  NRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPPA 145
             L W+ +++  +  +R+P D+VW P+IVL N  D       + NV++ + G + W  PA
Sbjct: 90  AYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPA 149

Query: 146 IFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEGF 205
           I +SSC + VTYFPFD Q C+L F S  Y   ++ +    D+             D   F
Sbjct: 150 ITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSG------------DLSDF 197

Query: 206 TENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVN 265
            E+ EWE+   PA  NV        P   D+TF L+++R+  FYI+N+L+PCVLISF+  
Sbjct: 198 IEDVEWEVHGMPAVKNVISYGCCSEP-YPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAP 256

Query: 266 LVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVV 325
           L FYLPA SGEK S+ +++LLA +VF L++++ +PA S  +PLIGK+ +  M L+T    
Sbjct: 257 LSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPA-SENVPLIGKYYIATMALITASTA 315

Query: 326 ICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPSPGALVRRSSSLGYIS 385
           + ++V+NIHF       +    + + L+ +  +L +    E   SP     R       S
Sbjct: 316 LTIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVGESCLSPHHSRERDHLTKVYS 375

Query: 386 KAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRPPASSEQAQQELFNELKPAVDGANFI 445
           K  E  L  +R+    +  S +  + +RL         + Q  +    + K       +I
Sbjct: 376 KLPESNLKAARN----KDLSRKKDMNKRLKNDLGCQGKNPQEAESYCAQYKVLTRNIEYI 431

Query: 446 VNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWI 488
              ++D    N +   W +VA+ +DR  +++   ++ V T  I
Sbjct: 432 AKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILI 474


>gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo
           sapiens]
          Length = 450

 Score =  232 bits (592), Expect = 5e-61
 Identities = 140/377 (37%), Positives = 206/377 (54%), Gaps = 26/377 (6%)

Query: 6   LTLGLLAALAVCGSWGLNEEERLIRHLFQE--KGYNKELRPVAHKEESVDVALALTLSNL 63
           L+LGLL  L +  +  L  E RL   LF++    Y   LRPVA  +++++V L +TLS +
Sbjct: 8   LSLGLLL-LFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQI 66

Query: 64  ISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSF 123
           I + E  + LT  +WI   WTD  L+W+   +G +  +R+P  +VW P+IVL N  D   
Sbjct: 67  IDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQP 126

Query: 124 QISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSL 183
             S S NV++ H G V W  PAI RSSC + V  FPFD Q+C L F S  +   ++ +  
Sbjct: 127 PGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRP 186

Query: 184 KQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIR 243
           +  A           + D   F EN EW ++  PAR  V        P   D+TF L++R
Sbjct: 187 RGAAAS---------LAD---FVENVEWRVLGMPARRRVLTYGCCSEP-YPDVTFTLLLR 233

Query: 244 RKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATS 303
           R+   Y+ N+L+PCVLIS +  L F+LPADSGEK S+ ++VLLA +VF LL+++ +P   
Sbjct: 234 RRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAE 293

Query: 304 MAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLP------- 356
            ++PLIGK+ +  M +VT    + ++++N+H+  PS   +    + L L  L        
Sbjct: 294 -SVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRE 352

Query: 357 --ELLHMSRPAEDGPSP 371
             E    SRP E  PSP
Sbjct: 353 RGEPCGQSRPPELSPSP 369


>gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]
          Length = 412

 Score =  180 bits (456), Expect = 3e-45
 Identities = 123/385 (31%), Positives = 185/385 (48%), Gaps = 29/385 (7%)

Query: 120 DGSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEI 179
           D  F  ++  NVLV   G   +LPP IF+SSC I V +FPFD Q+C LKF S  Y    +
Sbjct: 29  DERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSL 88

Query: 180 TLSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFY 239
            L +++               D  G+  NGEW++V  P + +         P   D+TF 
Sbjct: 89  DLQMQE--------------ADISGYIPNGEWDLVGIPGKRSERFYECCKEPY-PDVTFT 133

Query: 240 LIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRL 299
           + +RR+ L+Y +N+L+PCVLIS +  LVF LPADSGEK S+ I+VLL+ +VF+LL+++ +
Sbjct: 134 VTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIM 193

Query: 300 PATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELL 359
           PATS ++PLI ++    M++V + VV+ VIVL  H   P    + +  + + L      L
Sbjct: 194 PATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFL 253

Query: 360 HMSRPAEDGPSPGAL-VRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLT--- 415
            M RP ED   P     +R  SL  +  +       S  +L++       G+    T   
Sbjct: 254 RMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDS 313

Query: 416 --TARRPPASSEQAQQELFN--------ELKPAVDGANFIVNHMRDQNNYNEEKDSWNRV 465
                R   S    +  L          +L   ++   +I N  R Q+        W   
Sbjct: 314 GVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFA 373

Query: 466 ARTVDRLCLFVVTPVMVVGTAWIFL 490
           A  VDRLCL   +   ++ T  I +
Sbjct: 374 ACVVDRLCLMAFSVFTIICTIGILM 398


>gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform b
           precursor [Homo sapiens]
          Length = 484

 Score =  176 bits (446), Expect = 5e-44
 Identities = 104/328 (31%), Positives = 179/328 (54%), Gaps = 23/328 (7%)

Query: 38  YNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGN 97
           Y K +RPV    +   V++ + +  ++++ E  + LTT +W    WTD  L+WN E+F N
Sbjct: 51  YRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDN 110

Query: 98  ISVLRLPPDMVWLPEIVLENNND--GSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISV 155
           I+ L +P D +W+P+I++    D   S  I Y   V + H G V    P    ++C + +
Sbjct: 111 ITKLSIPTDSIWVPDILINEFVDVGKSPNIPY---VYIRHQGEVQNYKPLQVVTACSLDI 167

Query: 156 TYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVH 215
             FPFD QNCSL F+S  +T ++I +SL +  ++ ++        D   F   GEWE++ 
Sbjct: 168 YNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKS--------DRSVFMNQGEWELL- 218

Query: 216 RPARVNVDPR----APLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLP 271
                 V P     +   S    ++ FY++IRR+PLFY++++L+P + +  M  + FYLP
Sbjct: 219 -----GVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLP 273

Query: 272 ADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVL 331
            +SGE+ S  I++LL  SVFL+++S  LPAT++  PLIG + +  M L+ + +   + ++
Sbjct: 274 PNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIV 333

Query: 332 NIHFRTPSTHVLSEGVKKLFLETLPELL 359
            +  +      +   ++ L LE +  LL
Sbjct: 334 RLVHKQDLQQPVPAWLRHLVLERIAWLL 361


>gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform c
           [Homo sapiens]
          Length = 463

 Score =  176 bits (446), Expect = 5e-44
 Identities = 104/328 (31%), Positives = 179/328 (54%), Gaps = 23/328 (7%)

Query: 38  YNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGN 97
           Y K +RPV    +   V++ + +  ++++ E  + LTT +W    WTD  L+WN E+F N
Sbjct: 30  YRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDN 89

Query: 98  ISVLRLPPDMVWLPEIVLENNND--GSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISV 155
           I+ L +P D +W+P+I++    D   S  I Y   V + H G V    P    ++C + +
Sbjct: 90  ITKLSIPTDSIWVPDILINEFVDVGKSPNIPY---VYIRHQGEVQNYKPLQVVTACSLDI 146

Query: 156 TYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVH 215
             FPFD QNCSL F+S  +T ++I +SL +  ++ ++        D   F   GEWE++ 
Sbjct: 147 YNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKS--------DRSVFMNQGEWELL- 197

Query: 216 RPARVNVDPR----APLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLP 271
                 V P     +   S    ++ FY++IRR+PLFY++++L+P + +  M  + FYLP
Sbjct: 198 -----GVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLP 252

Query: 272 ADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVL 331
            +SGE+ S  I++LL  SVFL+++S  LPAT++  PLIG + +  M L+ + +   + ++
Sbjct: 253 PNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIV 312

Query: 332 NIHFRTPSTHVLSEGVKKLFLETLPELL 359
            +  +      +   ++ L LE +  LL
Sbjct: 313 RLVHKQDLQQPVPAWLRHLVLERIAWLL 340


>gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform a
           precursor [Homo sapiens]
          Length = 516

 Score =  170 bits (431), Expect = 3e-42
 Identities = 98/280 (35%), Positives = 159/280 (56%), Gaps = 23/280 (8%)

Query: 38  YNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGN 97
           Y K +RPV    +   V++ + +  ++++ E  + LTT +W    WTD  L+WN E+F N
Sbjct: 51  YRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDN 110

Query: 98  ISVLRLPPDMVWLPEIVLENNND--GSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISV 155
           I+ L +P D +W+P+I++    D   S  I Y   V + H G V    P    ++C + +
Sbjct: 111 ITKLSIPTDSIWVPDILINEFVDVGKSPNIPY---VYIRHQGEVQNYKPLQVVTACSLDI 167

Query: 156 TYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVH 215
             FPFD QNCSL F+S  +T ++I +SL +  ++ ++        D   F   GEWE++ 
Sbjct: 168 YNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKS--------DRSVFMNQGEWELL- 218

Query: 216 RPARVNVDPR----APLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLP 271
                 V P     +   S    ++ FY++IRR+PLFY++++L+P + +  M  + FYLP
Sbjct: 219 -----GVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLP 273

Query: 272 ADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGK 311
            +SGE+ S  I++LL  SVFL+++S  LPAT++  PLIGK
Sbjct: 274 PNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGK 313


>gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]
          Length = 321

 Score =  133 bits (335), Expect = 3e-31
 Identities = 94/304 (30%), Positives = 146/304 (48%), Gaps = 15/304 (4%)

Query: 201 DPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLI 260
           D  G+  NGEW++V  P + +         P   D+TF + +RR+ L+Y +N+L+PCVLI
Sbjct: 5   DISGYIPNGEWDLVGIPGKRSERFYECCKEPY-PDVTFTVTMRRRTLYYGLNLLIPCVLI 63

Query: 261 SFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLV 320
           S +  LVF LPADSGEK S+ I+VLL+ +VF+LL+++ +PATS ++PLI ++    M++V
Sbjct: 64  SALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIV 123

Query: 321 TMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPSPGAL-VRRSS 379
            + VV+ VIVL  H   P    + +  + + L      L M RP ED   P     +R  
Sbjct: 124 GLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRC 183

Query: 380 SLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLT-----TARRPPASSEQAQQELFN- 433
           SL  +  +       S  +L++       G+    T        R   S    +  L   
Sbjct: 184 SLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGG 243

Query: 434 -------ELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTA 486
                  +L   ++   +I N  R Q+        W   A  VDRLCL   +   ++ T 
Sbjct: 244 QPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTI 303

Query: 487 WIFL 490
            I +
Sbjct: 304 GILM 307


>gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]
          Length = 447

 Score =  132 bits (332), Expect = 8e-31
 Identities = 93/342 (27%), Positives = 160/342 (46%), Gaps = 25/342 (7%)

Query: 32  LFQEKGYNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWTDNRLKWN 91
           +FQ     K  RP  +      V ++ TLS ++ +    + LT+ +W++  W +  + WN
Sbjct: 44  VFQAVFDRKAFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWN 103

Query: 92  AEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPPAIFRSSC 151
            +E   I+ L +  + +WLP+I +  + D   Q        +   G + +  P    S C
Sbjct: 104 PKECVGINKLTVLAENLWLPDIFIVESMDVD-QTPSGLTAYISSEGRIKYDKPMRVTSIC 162

Query: 152 PISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEG--FTENG 209
            + + YFPFD QNC+  FSS  YT   + L + ++          W I D         G
Sbjct: 163 NLDIFYFPFDQQNCTFTFSSFLYTVDSMLLGMDKEV---------WEITDTSRKVIQTQG 213

Query: 210 EWEIVHRPARVN-VDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVF 268
           EWE++     +N   P+  + +     I FY+ IRR+P  YIIN+LVP   +  +  L F
Sbjct: 214 EWELLG----INKATPKMSMGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSF 269

Query: 269 YLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICV 328
           YLPA+S  +    I++LL  +VFLL+++  LPA+   +  +   L   +++V+++  + +
Sbjct: 270 YLPAESENRAPFKITLLLGYNVFLLMMNDLLPASGTPLISVYFALCLSLMVVSLLETVFI 329

Query: 329 IVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPS 370
             L +H  T     +   +  L       LLH + P    P+
Sbjct: 330 TYL-LHVATTQPPPMPRWLHSL-------LLHCTSPGRCCPT 363


>gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]
          Length = 471

 Score =  132 bits (331), Expect = 1e-30
 Identities = 92/337 (27%), Positives = 153/337 (45%), Gaps = 19/337 (5%)

Query: 40  KELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNIS 99
           K  RPV +      V ++  +S ++ + E    L++ +W+E  W +  + WN EE   I+
Sbjct: 67  KPFRPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGIT 126

Query: 100 VLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFP 159
            + +    +WLP+I +    D   +        V + G + +  P    S C + + YFP
Sbjct: 127 KMSMAAKNLWLPDIFIIELMDVD-KTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFP 185

Query: 160 FDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEG--FTENGEWEIVHRP 217
           FD QNC+L FSS  YT   + L ++++          W I D        +GEWE++   
Sbjct: 186 FDQQNCTLTFSSFLYTVDSMLLDMEKEV---------WEITDASRNILQTHGEWELL--- 233

Query: 218 ARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEK 277
                  +          I FY+ IRR+P  Y+IN+LVP   +  +  L FYLP  SG +
Sbjct: 234 GLSKATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNR 293

Query: 278 TSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLN-IHFR 336
               I++LL  +VFLL++S  LP +    PLIG +    + L+   ++  + + + +H  
Sbjct: 294 VPFKITLLLGYNVFLLMMSDLLPTS--GTPLIGVYFALCLSLMVGSLLETIFITHLLHVA 351

Query: 337 TPSTHVLSEGVKKLFLE-TLPELLHMSRPAEDGPSPG 372
           T     L   +  L L    P     + P ++   PG
Sbjct: 352 TTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPG 388


>gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor
           [Homo sapiens]
          Length = 441

 Score =  129 bits (324), Expect = 6e-30
 Identities = 82/326 (25%), Positives = 159/326 (48%), Gaps = 18/326 (5%)

Query: 10  LLAALAVCGSWGLNEEERLIRHLFQE--KGYNKELRPVAHKEESVDVALALTLSNLISLK 67
           +L A  +  +   + ++  + HL ++  + Y+KE+RPV +  ++  V L L +  ++ + 
Sbjct: 13  ILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVD 72

Query: 68  EVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSF--QI 125
              + L T+VW +  W D  L WN+  F  I  + LP   +W P+I++    D      +
Sbjct: 73  AENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDL 132

Query: 126 SYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQ 185
            Y   V V   G +    P    S+C +    FPFD QNCSL F S+ +T +++ L+  +
Sbjct: 133 PY---VYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLR 189

Query: 186 DAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRK 245
             ++        I  D + F  + EWE++   +  ++       +     I F +++RR 
Sbjct: 190 SPED--------IQHDKKAFLNDSEWELLSVSSTYSI---LQSSAGGFAQIQFNVVMRRH 238

Query: 246 PLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMA 305
           PL Y++++L+P + +  +    FYLP +   +     SVL+  +VF + +S ++P +  +
Sbjct: 239 PLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGS 298

Query: 306 IPLIGKFLLFGMVLVTMVVVICVIVL 331
            PLIG F    M  + + +   ++++
Sbjct: 299 TPLIGHFFTICMAFLVLSLAKSIVLV 324


>gi|157389018 gamma-aminobutyric acid A receptor, alpha 6 precursor
           [Homo sapiens]
          Length = 453

 Score = 70.1 bits (170), Expect = 5e-12
 Identities = 66/298 (22%), Positives = 123/298 (41%), Gaps = 18/298 (6%)

Query: 11  LAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISLKEVE 70
           L  L V G++      R++ +L +  GY+  LRP        +V   + +++   + +VE
Sbjct: 18  LGKLEVEGNFYSENVSRILDNLLE--GYDNRLRP-GFGGAVTEVKTDIYVTSFGPVSDVE 74

Query: 71  ETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCN 130
              T +V+    WTD RLK+       +S+  L    +W P+    N          + N
Sbjct: 75  MEYTMDVFFRQTWTDERLKFGGPT-EILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPN 133

Query: 131 VL--VYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAK 188
            L  +   G + +       + CP+ +  FP D   C LKF S  Y   EI  +     K
Sbjct: 134 KLFRIMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTW----K 189

Query: 189 ENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLF 248
           +   Y VE     PE  +   +++++ +            ++     +T Y  ++RK  +
Sbjct: 190 KGPLYSVE----VPEESSSLLQYDLIGQTVS---SETIKSNTGEYVIMTVYFHLQRKMGY 242

Query: 249 YIINILVPCVLISFMVNLVFYLPADS-GEKTSVAISVLLAQSVFLLLISKRLPATSMA 305
           ++I I  PC++   +  + F++  +S   +T   I+ +L  +   +     LP  S A
Sbjct: 243 FMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYA 300


>gi|34452723 gamma-aminobutyric acid A receptor, alpha 4 precursor
           [Homo sapiens]
          Length = 554

 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 76/312 (24%), Positives = 127/312 (40%), Gaps = 41/312 (13%)

Query: 14  LAVC--GSWGLNE-EERLIRHLFQE------KGYNKELRPVAHKEESVDVALALTLSNLI 64
           LAVC   S G N+ EE+L    F         GY+  LRP        +V   + +++  
Sbjct: 26  LAVCLNESPGQNQKEEKLCTENFTRILDSLLDGYDNRLRP-GFGGPVTEVKTDIYVTSFG 84

Query: 65  SLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMV---WLPEIVLENNNDG 121
            + +VE   T +V+    W D RLK++    G I +LRL   MV   W P+    N    
Sbjct: 85  PVSDVEMEYTMDVFFRQTWIDKRLKYD----GPIEILRLNNMMVTKVWTPDTFFRNGKKS 140

Query: 122 SFQISYSCNVL--VYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEI 179
                 + N L  +   G + +       + CP+ +  FP D   C LKF S  Y   E+
Sbjct: 141 VSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEM 200

Query: 180 TLSLKQDAKENRTYPVE---WIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDI 236
             +  +  +++   P E    +  D  G T + E                 + S + + I
Sbjct: 201 IYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSE----------------TIKSITGEYI 244

Query: 237 --TFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLPADS-GEKTSVAISVLLAQSVFLL 293
             T Y  +RRK  +++I   +PC++   +  + F++  +S   +T   I+ +L  +   +
Sbjct: 245 VMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSI 304

Query: 294 LISKRLPATSMA 305
                LP  S A
Sbjct: 305 SARHSLPKVSYA 316


>gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3
           [Homo sapiens]
          Length = 467

 Score = 66.2 bits (160), Expect = 7e-11
 Identities = 60/273 (21%), Positives = 120/273 (43%), Gaps = 26/273 (9%)

Query: 38  YNKELRP-VAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFG 96
           Y+K+LRP +  K   +DV + +     +S   +E  +  +++    WTD+RL++N+    
Sbjct: 58  YDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQI--DIFFAQTWTDSRLRFNS---- 111

Query: 97  NISVLRLPPDMV---WLPEIVLENNNDGSFQISYSCNVL--VYHYGFVYWLPPAIFRSSC 151
            + +L L  +MV   W+P+ +  N+         + N L  +++ G + +       + C
Sbjct: 112 TMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAEC 171

Query: 152 PISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEGFTENGEW 211
            + +  FP D  +C L FSS  Y  +E+    ++++ E       W +   +        
Sbjct: 172 QLQLHNFPMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQK-SWRLYQFDFMGLRNTT 230

Query: 212 EIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLP 271
           EIV   A   V             +T Y  + R+  ++ I   +PC+L   +  + F++ 
Sbjct: 231 EIVTTSAGDYV------------VMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIK 278

Query: 272 AD-SGEKTSVAISVLLAQSVFLLLISKRLPATS 303
            D +  +T++ I+ +L  +    +  K LP  S
Sbjct: 279 KDATPARTALGITTVLTMTTLSTIARKSLPRVS 311


>gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform 2
           precursor [Homo sapiens]
          Length = 467

 Score = 65.9 bits (159), Expect = 9e-11
 Identities = 60/274 (21%), Positives = 118/274 (43%), Gaps = 24/274 (8%)

Query: 36  KGYNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEF 95
           +GY+ +LRP    + ++ +   + ++++  +  +    T +++    W D RLK+N+   
Sbjct: 75  EGYDNKLRPDIGVKPTL-IHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNS--- 130

Query: 96  GNISVLRLPPDMV---WLPEIVLENNN--DGSFQISYSCNVLVYHYGFVYWLPPAIFRSS 150
             I VLRL  +MV   W+P+    N+   D  +  + +  + +++ G V +       + 
Sbjct: 131 -TIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189

Query: 151 CPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEGFTENGE 210
           C + +  FP D  +C L+FSS  Y  +EI    K+ + E              G T +  
Sbjct: 190 CQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVE-------------VGDTRSWR 236

Query: 211 WEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYL 270
                     N        S     ++ Y  + R+  ++ I   +PC LI  +  + F++
Sbjct: 237 LYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWI 296

Query: 271 PADS-GEKTSVAISVLLAQSVFLLLISKRLPATS 303
             D+   +TS+ I+ +L  +    +  K LP  S
Sbjct: 297 NKDAVPARTSLGITTVLTMTTLSTIARKSLPKVS 330


>gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform 1
           precursor [Homo sapiens]
          Length = 475

 Score = 65.9 bits (159), Expect = 9e-11
 Identities = 60/274 (21%), Positives = 118/274 (43%), Gaps = 24/274 (8%)

Query: 36  KGYNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEF 95
           +GY+ +LRP    + ++ +   + ++++  +  +    T +++    W D RLK+N+   
Sbjct: 75  EGYDNKLRPDIGVKPTL-IHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNS--- 130

Query: 96  GNISVLRLPPDMV---WLPEIVLENNN--DGSFQISYSCNVLVYHYGFVYWLPPAIFRSS 150
             I VLRL  +MV   W+P+    N+   D  +  + +  + +++ G V +       + 
Sbjct: 131 -TIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189

Query: 151 CPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEGFTENGE 210
           C + +  FP D  +C L+FSS  Y  +EI    K+ + E              G T +  
Sbjct: 190 CQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVE-------------VGDTRSWR 236

Query: 211 WEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYL 270
                     N        S     ++ Y  + R+  ++ I   +PC LI  +  + F++
Sbjct: 237 LYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWI 296

Query: 271 PADS-GEKTSVAISVLLAQSVFLLLISKRLPATS 303
             D+   +TS+ I+ +L  +    +  K LP  S
Sbjct: 297 NKDAVPARTSLGITTVLTMTTLSTIARKSLPKVS 330


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.421 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,853,774
Number of Sequences: 37866
Number of extensions: 936144
Number of successful extensions: 2581
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 2395
Number of HSP's gapped (non-prelim): 92
length of query: 517
length of database: 18,247,518
effective HSP length: 107
effective length of query: 410
effective length of database: 14,195,856
effective search space: 5820300960
effective search space used: 5820300960
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.