Search of human proteins with 4507173

Search of human proteins with 4507173

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens]
         (795 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens]             1576   0.0  
gi|40806173 spastic paraplegia 7 isoform 2 [Homo sapiens]             877   0.0  
gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens]            522   e-148
gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]                      312   7e-85
gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]                       312   7e-85
gi|6005942 valosin-containing protein [Homo sapiens]                  189   1e-47
gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]            187   4e-47
gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]             182   8e-46
gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]           182   1e-45
gi|157671927 spermatogenesis associated 5 [Homo sapiens]              181   3e-45
gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]            172   1e-42
gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit ...   170   5e-42
gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo sapi...   170   5e-42
gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]   170   5e-42
gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]                 169   7e-42
gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]                 169   7e-42
gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]            165   1e-40
gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]       156   6e-38
gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]           154   2e-37
gi|4505725 peroxin1 [Homo sapiens]                                    137   4e-32
gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]     135   1e-31
gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]   131   2e-30
gi|5901990 katanin p60 subunit A 1 [Homo sapiens]                     130   5e-30
gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]               127   3e-29
gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]               127   3e-29
gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens]              127   5e-29
gi|169167838 PREDICTED: similar to hCG2002932 [Homo sapiens]          125   2e-28
gi|239748566 PREDICTED: similar to hCG2002932 [Homo sapiens]          125   2e-28
gi|239742549 PREDICTED: hypothetical protein LOC345645 [Homo sap...   125   2e-28
gi|40806170 spastin isoform 2 [Homo sapiens]                          118   2e-26

>gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens]
          Length = 795

 Score = 1576 bits (4080), Expect = 0.0
 Identities = 795/795 (100%), Positives = 795/795 (100%)

Query: 1   MAVLLLLLRALRRGPGPGPRPLWGPGPAWSPGFPARPGRGRPYMASRPPGDLAEAGGRAL 60
           MAVLLLLLRALRRGPGPGPRPLWGPGPAWSPGFPARPGRGRPYMASRPPGDLAEAGGRAL
Sbjct: 1   MAVLLLLLRALRRGPGPGPRPLWGPGPAWSPGFPARPGRGRPYMASRPPGDLAEAGGRAL 60

Query: 61  QSLQLRLLTPTFEGINGLLLKQHLVQNPVRLWQLLGGTFYFNTSRLKQKNKEKDKSKGKA 120
           QSLQLRLLTPTFEGINGLLLKQHLVQNPVRLWQLLGGTFYFNTSRLKQKNKEKDKSKGKA
Sbjct: 61  QSLQLRLLTPTFEGINGLLLKQHLVQNPVRLWQLLGGTFYFNTSRLKQKNKEKDKSKGKA 120

Query: 121 PEEDEEERRRRERDDQMYRERLRTLLVIAVVMSLLNALSTSGGSISWNDFVHEMLAKGEV 180
           PEEDEEERRRRERDDQMYRERLRTLLVIAVVMSLLNALSTSGGSISWNDFVHEMLAKGEV
Sbjct: 121 PEEDEEERRRRERDDQMYRERLRTLLVIAVVMSLLNALSTSGGSISWNDFVHEMLAKGEV 180

Query: 181 QRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDR 240
           QRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDR
Sbjct: 181 QRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDR 240

Query: 241 IPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDG 300
           IPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDG
Sbjct: 241 IPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDG 300

Query: 301 KMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAK 360
           KMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAK
Sbjct: 301 KMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAK 360

Query: 361 AVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTT 420
           AVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTT
Sbjct: 361 AVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTT 420

Query: 421 MSGFSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLP 480
           MSGFSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLP
Sbjct: 421 MSGFSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLP 480

Query: 481 TLQERREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSV 540
           TLQERREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSV
Sbjct: 481 TLQERREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSV 540

Query: 541 HTLNFEYAVERVLAGTAKKSKILSKEEQKVVAFHESGHALVGWMLEHTEAVMKVSITPRT 600
           HTLNFEYAVERVLAGTAKKSKILSKEEQKVVAFHESGHALVGWMLEHTEAVMKVSITPRT
Sbjct: 541 HTLNFEYAVERVLAGTAKKSKILSKEEQKVVAFHESGHALVGWMLEHTEAVMKVSITPRT 600

Query: 601 NAALGFAQMLPRDQHLFTKEQLFERMCMALGGRASEALSFNEVTSGAQDDLRKVTRIAYS 660
           NAALGFAQMLPRDQHLFTKEQLFERMCMALGGRASEALSFNEVTSGAQDDLRKVTRIAYS
Sbjct: 601 NAALGFAQMLPRDQHLFTKEQLFERMCMALGGRASEALSFNEVTSGAQDDLRKVTRIAYS 660

Query: 661 MVKQFGMAPGIGPISFPEAQEGLMGIGRRPFSQGLQQMMDHEARLLVAKAYRHTEKVLQD 720
           MVKQFGMAPGIGPISFPEAQEGLMGIGRRPFSQGLQQMMDHEARLLVAKAYRHTEKVLQD
Sbjct: 661 MVKQFGMAPGIGPISFPEAQEGLMGIGRRPFSQGLQQMMDHEARLLVAKAYRHTEKVLQD 720

Query: 721 NLDKLQALANALLEKEVINYEDIEALIGPPPHGPKKMIAPQRWIDAQREKQDLGEEETEE 780
           NLDKLQALANALLEKEVINYEDIEALIGPPPHGPKKMIAPQRWIDAQREKQDLGEEETEE
Sbjct: 721 NLDKLQALANALLEKEVINYEDIEALIGPPPHGPKKMIAPQRWIDAQREKQDLGEEETEE 780

Query: 781 TQQPPLGGEEPTWPK 795
           TQQPPLGGEEPTWPK
Sbjct: 781 TQQPPLGGEEPTWPK 795


>gi|40806173 spastic paraplegia 7 isoform 2 [Homo sapiens]
          Length = 489

 Score =  877 bits (2265), Expect = 0.0
 Identities = 442/442 (100%), Positives = 442/442 (100%)

Query: 1   MAVLLLLLRALRRGPGPGPRPLWGPGPAWSPGFPARPGRGRPYMASRPPGDLAEAGGRAL 60
           MAVLLLLLRALRRGPGPGPRPLWGPGPAWSPGFPARPGRGRPYMASRPPGDLAEAGGRAL
Sbjct: 1   MAVLLLLLRALRRGPGPGPRPLWGPGPAWSPGFPARPGRGRPYMASRPPGDLAEAGGRAL 60

Query: 61  QSLQLRLLTPTFEGINGLLLKQHLVQNPVRLWQLLGGTFYFNTSRLKQKNKEKDKSKGKA 120
           QSLQLRLLTPTFEGINGLLLKQHLVQNPVRLWQLLGGTFYFNTSRLKQKNKEKDKSKGKA
Sbjct: 61  QSLQLRLLTPTFEGINGLLLKQHLVQNPVRLWQLLGGTFYFNTSRLKQKNKEKDKSKGKA 120

Query: 121 PEEDEEERRRRERDDQMYRERLRTLLVIAVVMSLLNALSTSGGSISWNDFVHEMLAKGEV 180
           PEEDEEERRRRERDDQMYRERLRTLLVIAVVMSLLNALSTSGGSISWNDFVHEMLAKGEV
Sbjct: 121 PEEDEEERRRRERDDQMYRERLRTLLVIAVVMSLLNALSTSGGSISWNDFVHEMLAKGEV 180

Query: 181 QRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDR 240
           QRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDR
Sbjct: 181 QRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDR 240

Query: 241 IPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDG 300
           IPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDG
Sbjct: 241 IPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDG 300

Query: 301 KMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAK 360
           KMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAK
Sbjct: 301 KMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAK 360

Query: 361 AVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTT 420
           AVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTT
Sbjct: 361 AVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTT 420

Query: 421 MSGFSNTEEEQTLNQLLVEMDG 442
           MSGFSNTEEEQTLNQLLVEMDG
Sbjct: 421 MSGFSNTEEEQTLNQLLVEMDG 442


>gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens]
          Length = 797

 Score =  522 bits (1345), Expect = e-148
 Identities = 297/642 (46%), Positives = 406/642 (63%), Gaps = 27/642 (4%)

Query: 158 LSTSGGSISWNDFVHEMLAKGEVQRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVA 217
           L  SG  I+W DFV+  L+KG V R++VV +   V V   PG      P         + 
Sbjct: 163 LKRSGREITWKDFVNNYLSKGVVDRLEVVNKR-FVRVTFTPGKT----PVDGQYVWFNIG 217

Query: 218 NIDKFEEKLRAAEDELNIEAKDRIPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLA-- 275
           ++D FE  L   + EL IE ++R+PV Y      G+ L S+  T + +A L Y  R    
Sbjct: 218 SVDTFERNLETLQQELGIEGENRVPVVYIAESD-GSFLLSMLPTVLIIAFLLYTIRRGPA 276

Query: 276 --GMTGREGGFSAFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLKSPER 333
             G TGR  G        +   T    K    V FKDVAG  EAKLE+ EFV++LK+P++
Sbjct: 277 GIGRTGRGMG----GLFSVGETTAKVLKDEIDVKFKDVAGCEEAKLEIMEFVNFLKNPKQ 332

Query: 334 FLQLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSL 393
           +  LGAK+PKGA+L GPPG GKTLLAKA A EA VPF+ ++G EF+E+  G+G ARVR L
Sbjct: 333 YQDLGAKIPKGAILTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPARVRDL 392

Query: 394 FKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDGMGTTDHVIVLA 453
           F  AR  APCI++IDEIDAVG+KR     G   +E+E TLNQLLVEMDG  TT +V++LA
Sbjct: 393 FALARKNAPCILFIDEIDAVGRKRGRGNFG-GQSEQENTLNQLLVEMDGFNTTTNVVILA 451

Query: 454 STNRADILDGALMRPGRLDRHVFIDLPTLQERREIFEQHLKSLKL--TQSSTFYSQRLAE 511
            TNR DILD AL+RPGR DR +FI  P ++ R  IF+ HL+ LKL  T      +++LA 
Sbjct: 452 GTNRPDILDPALLRPGRFDRQIFIGPPDIKGRASIFKVHLRPLKLDSTLEKDKLARKLAS 511

Query: 512 LTPGFSGADIANICNEAALHAAREGHTSVHTLNFEYAVERVLAGTAKKSKILSKEEQKVV 571
           LTPGFSGAD+AN+CNEAAL AAR    S++  +FE A+ERV+ G  KK+++L  EE+K V
Sbjct: 512 LTPGFSGADVANVCNEAALIAARHLSDSINQKHFEQAIERVIGGLEKKTQVLQPEEKKTV 571

Query: 572 AFHESGHALVGWMLEHTEAVMKVSITPRTNAALGFAQMLPRDQHLFTKEQLFERMCMALG 631
           A+HE+GHA+ GW LEH + ++KVSI PR    LG+AQ LP++Q+L+TKEQL +RMCM LG
Sbjct: 572 AYHEAGHAVAGWYLEHADPLLKVSIIPR-GKGLGYAQYLPKEQYLYTKEQLLDRMCMTLG 630

Query: 632 GRASEALSFNEVTSGAQDDLRKVTRIAYSMVKQFGMAPGIGPISFPEAQEGLMGIGRRPF 691
           GRASE + F  +T+GAQDDLRKVT+ AY+ + QFGM   +G ISF   ++G M +  +P+
Sbjct: 631 GRASEEIFFGRITTGAQDDLRKVTQSAYAQIVQFGMNEKVGQISFDLPRQGDM-VLEKPY 689

Query: 692 SQGLQQMMDHEARLLVAKAYRHTEKVLQDNLDKLQALANALLEKEVINYEDIEALIGPPP 751
           S+   +++D E R+L+  AY+ T  +L +    ++ +A  LLEKEV++  D+  L+GP P
Sbjct: 690 SEATARLIDDEVRILINDAYKRTVALLTEKKADVEKVALLLLEKEVLDKNDMVELLGPRP 749

Query: 752 HGPK----KMIAPQRWIDAQRE----KQDLGEEETEETQQPP 785
              K    + +     +D         +D  +E  +E ++PP
Sbjct: 750 FAEKSTYEEFVEGTGSLDEDTSLPEGLKDWNKEREKEKEEPP 791


>gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]
          Length = 773

 Score =  312 bits (800), Expect = 7e-85
 Identities = 175/454 (38%), Positives = 279/454 (61%), Gaps = 20/454 (4%)

Query: 298 VDGKMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTL 357
           VD    K V+F+ V G+ EAK E++E V++LK+P++F  LG K+PKG LL+GPPG GKTL
Sbjct: 328 VDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTILGGKLPKGILLVGPPGTGKTL 387

Query: 358 LAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKR 417
           LA+AVA EA VPF   +G EF E+  G+GA+R+R+LF+EA+A APC+++IDE+D+VG KR
Sbjct: 388 LARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKR 447

Query: 418 -STTMSGFSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVF 476
             + M  +S     QT+NQLL EMDG    + VI++ +TN  + LD AL+RPGR D  V 
Sbjct: 448 IESPMHPYS----RQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVT 503

Query: 477 IDLPTLQERREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAREG 536
           +  P ++ R EI + +L  +K  QS     + +A  T GFSGA++ N+ N+AAL AA +G
Sbjct: 504 VPRPDVKGRTEILKWYLNKIKFDQSVD--PEIIARGTVGFSGAELENLVNQAALKAAVDG 561

Query: 537 HTSVHTLNFEYAVERVLAGTAKKSKILSKEEQKVVAFHESGHALVGWMLEHTEAVMKVSI 596
              V     E++ +++L G  ++S  +  + + + A+HESGHA++ +  +    + K +I
Sbjct: 562 KEMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATI 621

Query: 597 TPRTNAALGFAQMLP-RDQHLFTKEQLFERMCMALGGRASEALSF--NEVTSGAQDDLRK 653
            PR    LG   +LP  D+   T+ QL  +M +++GGR +E L F  + +T+GA  D   
Sbjct: 622 MPR-GPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDN 680

Query: 654 VTRIAYSMVKQFGMAPGIGPISFPEAQEGLMGIGRRPFSQGLQQMMDHEARLLVAKAYRH 713
            T+IA  MV +FGM+  +G +++ +  +          S   Q  ++ E R+L+  +Y  
Sbjct: 681 ATKIAKRMVTKFGMSEKLGVMTYSDTGK---------LSPETQSAIEQEIRILLRDSYER 731

Query: 714 TEKVLQDNLDKLQALANALLEKEVINYEDIEALI 747
            + +L+ +  + + LA ALL  E ++ ++I+ ++
Sbjct: 732 AKHILKTHAKEHKNLAEALLTYETLDAKEIQIVL 765


>gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]
          Length = 716

 Score =  312 bits (800), Expect = 7e-85
 Identities = 175/454 (38%), Positives = 279/454 (61%), Gaps = 20/454 (4%)

Query: 298 VDGKMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTL 357
           VD    K V+F+ V G+ EAK E++E V++LK+P++F  LG K+PKG LL+GPPG GKTL
Sbjct: 271 VDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTILGGKLPKGILLVGPPGTGKTL 330

Query: 358 LAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKR 417
           LA+AVA EA VPF   +G EF E+  G+GA+R+R+LF+EA+A APC+++IDE+D+VG KR
Sbjct: 331 LARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKR 390

Query: 418 -STTMSGFSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVF 476
             + M  +S     QT+NQLL EMDG    + VI++ +TN  + LD AL+RPGR D  V 
Sbjct: 391 IESPMHPYS----RQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVT 446

Query: 477 IDLPTLQERREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAREG 536
           +  P ++ R EI + +L  +K  QS     + +A  T GFSGA++ N+ N+AAL AA +G
Sbjct: 447 VPRPDVKGRTEILKWYLNKIKFDQSVD--PEIIARGTVGFSGAELENLVNQAALKAAVDG 504

Query: 537 HTSVHTLNFEYAVERVLAGTAKKSKILSKEEQKVVAFHESGHALVGWMLEHTEAVMKVSI 596
              V     E++ +++L G  ++S  +  + + + A+HESGHA++ +  +    + K +I
Sbjct: 505 KEMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATI 564

Query: 597 TPRTNAALGFAQMLP-RDQHLFTKEQLFERMCMALGGRASEALSF--NEVTSGAQDDLRK 653
            PR    LG   +LP  D+   T+ QL  +M +++GGR +E L F  + +T+GA  D   
Sbjct: 565 MPR-GPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDN 623

Query: 654 VTRIAYSMVKQFGMAPGIGPISFPEAQEGLMGIGRRPFSQGLQQMMDHEARLLVAKAYRH 713
            T+IA  MV +FGM+  +G +++ +  +          S   Q  ++ E R+L+  +Y  
Sbjct: 624 ATKIAKRMVTKFGMSEKLGVMTYSDTGK---------LSPETQSAIEQEIRILLRDSYER 674

Query: 714 TEKVLQDNLDKLQALANALLEKEVINYEDIEALI 747
            + +L+ +  + + LA ALL  E ++ ++I+ ++
Sbjct: 675 AKHILKTHAKEHKNLAEALLTYETLDAKEIQIVL 708


>gi|6005942 valosin-containing protein [Homo sapiens]
          Length = 806

 Score =  189 bits (479), Expect = 1e-47
 Identities = 95/231 (41%), Positives = 147/231 (63%), Gaps = 4/231 (1%)

Query: 306 VSFKDVAGMHEAKLEVREFVDY-LKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVAT 364
           V+++D+ G+ + K E++E V Y ++ P++FL+ G    KG L  GPPGCGKTLLAKA+A 
Sbjct: 474 VTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIAN 533

Query: 365 EAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGF 424
           E Q  F+++ GPE + +  G   A VR +F +AR  APC+++ DE+D++ K R   + G 
Sbjct: 534 ECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNI-GD 592

Query: 425 SNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQE 484
                ++ +NQ+L EMDGM T  +V ++ +TNR DI+D A++RPGRLD+ ++I LP  + 
Sbjct: 593 GGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKS 652

Query: 485 RREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAARE 535
           R  I + +L+   + +      + LA++T GFSGAD+  IC  A   A RE
Sbjct: 653 RVAILKANLRKSPVAKDVDL--EFLAKMTNGFSGADLTEICQRACKLAIRE 701



 Score =  167 bits (424), Expect = 3e-41
 Identities = 94/231 (40%), Positives = 135/231 (58%), Gaps = 7/231 (3%)

Query: 306 VSFKDVAGMHEAKLEVREFVDY-LKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVAT 364
           V + D+ G  +   +++E V+  L+ P  F  +G K P+G LL GPPG GKTL+A+AVA 
Sbjct: 201 VGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVAN 260

Query: 365 EAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGF 424
           E    F  + GPE +  + G   + +R  F+EA   AP I++IDE+DA+  KR  T    
Sbjct: 261 ETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKT---- 316

Query: 425 SNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQE 484
               E + ++QLL  MDG+    HVIV+A+TNR + +D AL R GR DR V I +P    
Sbjct: 317 HGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATG 376

Query: 485 RREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAARE 535
           R EI + H K++KL        +++A  T G  GAD+A +C+EAAL A R+
Sbjct: 377 RLEILQIHTKNMKLADDVDL--EQVANETHGHVGADLAALCSEAALQAIRK 425


>gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]
          Length = 406

 Score =  187 bits (474), Expect = 4e-47
 Identities = 102/260 (39%), Positives = 159/260 (61%), Gaps = 4/260 (1%)

Query: 307 SFKDVAGMHEAKLEVREFVDY-LKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATE 365
           +++ + G+ +   E++E ++  +K PE F  LG   PKG LL GPPG GKTLLA+AVA  
Sbjct: 147 TYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHH 206

Query: 366 AQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFS 425
               F+ ++G E V+   G GA  VR LF  AR  AP I+++DEID++G  R    SG  
Sbjct: 207 TDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSG-G 265

Query: 426 NTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQER 485
           ++E ++T+ +LL ++DG   T ++ V+ +TNR DILD AL+RPGR+DR +    P  + R
Sbjct: 266 DSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEAR 325

Query: 486 REIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSVHTLNF 545
            +I + H + + LT+      +++AEL PG SGA++  +C EA ++A RE    V   +F
Sbjct: 326 LDILKIHSRKMNLTRGINL--RKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDF 383

Query: 546 EYAVERVLAGTAKKSKILSK 565
           E AV +V+   ++K+  + K
Sbjct: 384 EMAVAKVMQKDSEKNMSIKK 403


>gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]
          Length = 433

 Score =  182 bits (463), Expect = 8e-46
 Identities = 106/256 (41%), Positives = 150/256 (58%), Gaps = 4/256 (1%)

Query: 306 VSFKDVAGMHEAKLEVREFVDY-LKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVAT 364
           V++ DV G  E   ++RE V+  L  PERF+ LG + PKG LL GPPG GKTL A+AVA 
Sbjct: 172 VTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVAN 231

Query: 365 EAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGF 424
                F+ + G E V+   G GA  VR LF+ AR +  C+++ DEIDA+G  R    +G 
Sbjct: 232 RTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGG 291

Query: 425 SNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQE 484
            N E ++T+ +L+ ++DG     ++ VL +TNR D LD ALMRPGRLDR +   LP L+ 
Sbjct: 292 DN-EVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEG 350

Query: 485 RREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSVHTLN 544
           R  IF+ H +S+ + +   F  + LA L P  +GA+I ++C EA + A R         +
Sbjct: 351 RTHIFKIHARSMSVERDIRF--ELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKD 408

Query: 545 FEYAVERVLAGTAKKS 560
           F  AV +V+   AK S
Sbjct: 409 FLEAVNKVIKSYAKFS 424


>gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]
          Length = 403

 Score =  182 bits (462), Expect = 1e-45
 Identities = 107/267 (40%), Positives = 159/267 (59%), Gaps = 8/267 (2%)

Query: 306 VSFKDVAGMHEAKLEVREFVDY-LKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVAT 364
           VS+ ++ G+ E   E+RE ++  L +PE F ++G   PKG LL GPPG GKTLLA+AVA+
Sbjct: 144 VSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVAS 203

Query: 365 EAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGF 424
           +    FL +     V+   G  A  +R +F  AR   PCI+++DEIDA+G +R +  +  
Sbjct: 204 QLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTS- 262

Query: 425 SNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQE 484
           ++ E ++TL +LL +MDG  T   V ++ +TNR D LD AL+RPGRLDR + IDLP  Q 
Sbjct: 263 ADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQA 322

Query: 485 RREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSVHTLN 544
           R +I + H  +  +T+      + + +L+ GF+GAD+ N+C EA + A R  H  V   +
Sbjct: 323 RLDILKIH--AGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQED 380

Query: 545 FEYAVERVLAGTAKKSKILSKEEQKVV 571
           F  AV +V    A   K+ SK + K V
Sbjct: 381 FMKAVRKV----ADSKKLESKLDYKPV 403


>gi|157671927 spermatogenesis associated 5 [Homo sapiens]
          Length = 893

 Score =  181 bits (458), Expect = 3e-45
 Identities = 98/231 (42%), Positives = 145/231 (62%), Gaps = 5/231 (2%)

Query: 306 VSFKDVAGMHEAKLEVREFVDY-LKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVAT 364
           VS+ D+ G+   KL++ + V++ LK PE F+++G + PKG LL GPPGC KT++AKA+A 
Sbjct: 624 VSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALAN 683

Query: 365 EAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGF 424
           E+ + FLA+ GPE +    G     VR  F++ARA AP I++ DE+DA+  +R +++   
Sbjct: 684 ESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVERGSSLG-- 741

Query: 425 SNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQE 484
           +    ++ L QLL EMDG+     V +LA+TNR D +D ALMRPGR+DR +++ LP    
Sbjct: 742 AGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDKALMRPGRIDRIIYVPLPDAAT 801

Query: 485 RREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAARE 535
           RREIF+    S+ +  S+      L   T  +SGA+I  +C EAAL A  E
Sbjct: 802 RREIFKLQFHSMPV--SNEVDLDELILQTDAYSGAEIVAVCREAALLALEE 850



 Score =  150 bits (379), Expect = 4e-36
 Identities = 90/235 (38%), Positives = 132/235 (56%), Gaps = 13/235 (5%)

Query: 306 VSFKDVAGMHEAKLEVREFVDY-LKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVAT 364
           V++  + G+      +RE ++  LK PE F   G   P+G LL GPPG GKT++A+AVA 
Sbjct: 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVAN 409

Query: 365 EAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGF 424
           E       + GPE +    G   A++R +F EA  R P I++IDE+DA+  KR     G 
Sbjct: 410 EVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKR----EGA 465

Query: 425 SNTEEEQTLNQLLVEMDGMG---TTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPT 481
            N  E++ +  LL  MDG+G   +   V+VL +TNR   LD AL RPGR D+ + I +P 
Sbjct: 466 QNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPN 525

Query: 482 LQERREIFEQHLKSLK--LTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAR 534
            Q+R +I ++ L+ +   LT++      +LA    G+ GAD+  +CNEA L A R
Sbjct: 526 AQDRLDILQKLLRRVPHLLTEAELL---QLANSAHGYVGADLKVLCNEAGLCALR 577


>gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]
          Length = 440

 Score =  172 bits (435), Expect = 1e-42
 Identities = 101/248 (40%), Positives = 143/248 (57%), Gaps = 4/248 (1%)

Query: 307 SFKDVAGMHEAKLEVREFVDY-LKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATE 365
           ++ D+ G+     E++E V+  L  PE + ++G K PKG +L GPPG GKTLLAKAVA +
Sbjct: 183 TYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQ 242

Query: 366 AQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFS 425
               FL + G E ++   G G   VR LF+ A   AP IV+IDEIDA+G KR  + SG  
Sbjct: 243 TSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSG-G 301

Query: 426 NTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQER 485
             E ++T+ +LL ++DG  +   V V+ +TNR + LD AL+RPGR+DR +   LP  + +
Sbjct: 302 EREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTK 361

Query: 486 REIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSVHTLNF 545
           + IF+ H   + L    T     +A+     SGADI  IC EA L A RE    V   +F
Sbjct: 362 KRIFQIHTSRMTLADDVTLDDLIMAK--DDLSGADIKAICTEAGLMALRERRMKVTNEDF 419

Query: 546 EYAVERVL 553
           + + E VL
Sbjct: 420 KKSKENVL 427


>gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit 4
           [Homo sapiens]
          Length = 414

 Score =  170 bits (430), Expect = 5e-42
 Identities = 101/249 (40%), Positives = 143/249 (57%), Gaps = 4/249 (1%)

Query: 306 VSFKDVAGMHEAKLEVREFVDY-LKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVAT 364
           V + D+ GM   K EVRE V+  L   E + Q+G   P+G L+ GPPGCGKT+LAKAVA 
Sbjct: 158 VMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAH 217

Query: 365 EAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGF 424
                F+ + G EFV+   G G   VR +F+ A+  AP I++IDEIDA+  KR    +G 
Sbjct: 218 HTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTG- 276

Query: 425 SNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQE 484
           ++ E ++ L +LL +MDG     +V V+ +TNRAD LD AL+RPGRLDR +   LP  ++
Sbjct: 277 ADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQ 336

Query: 485 RREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSVHTLN 544
           +R IF      + L++      +         SGADI +IC E+ + A RE    V   +
Sbjct: 337 KRLIFSTITSKMNLSEEVDL--EDYVARPDKISGADINSICQESGMLAVRENRYIVLAKD 394

Query: 545 FEYAVERVL 553
           FE A + V+
Sbjct: 395 FEKAYKTVI 403


>gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo
           sapiens]
          Length = 387

 Score =  170 bits (430), Expect = 5e-42
 Identities = 101/249 (40%), Positives = 143/249 (57%), Gaps = 4/249 (1%)

Query: 306 VSFKDVAGMHEAKLEVREFVDY-LKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVAT 364
           V + D+ GM   K EVRE V+  L   E + Q+G   P+G L+ GPPGCGKT+LAKAVA 
Sbjct: 131 VMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAH 190

Query: 365 EAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGF 424
                F+ + G EFV+   G G   VR +F+ A+  AP I++IDEIDA+  KR    +G 
Sbjct: 191 HTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTG- 249

Query: 425 SNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQE 484
           ++ E ++ L +LL +MDG     +V V+ +TNRAD LD AL+RPGRLDR +   LP  ++
Sbjct: 250 ADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQ 309

Query: 485 RREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSVHTLN 544
           +R IF      + L++      +         SGADI +IC E+ + A RE    V   +
Sbjct: 310 KRLIFSTITSKMNLSEEVDL--EDYVARPDKISGADINSICQESGMLAVRENRYIVLAKD 367

Query: 545 FEYAVERVL 553
           FE A + V+
Sbjct: 368 FEKAYKTVI 376


>gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]
          Length = 418

 Score =  170 bits (430), Expect = 5e-42
 Identities = 101/249 (40%), Positives = 143/249 (57%), Gaps = 4/249 (1%)

Query: 306 VSFKDVAGMHEAKLEVREFVDY-LKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVAT 364
           V + D+ GM   K EVRE V+  L   E + Q+G   P+G L+ GPPGCGKT+LAKAVA 
Sbjct: 162 VMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAH 221

Query: 365 EAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGF 424
                F+ + G EFV+   G G   VR +F+ A+  AP I++IDEIDA+  KR    +G 
Sbjct: 222 HTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTG- 280

Query: 425 SNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQE 484
           ++ E ++ L +LL +MDG     +V V+ +TNRAD LD AL+RPGRLDR +   LP  ++
Sbjct: 281 ADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQ 340

Query: 485 RREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSVHTLN 544
           +R IF      + L++      +         SGADI +IC E+ + A RE    V   +
Sbjct: 341 KRLIFSTITSKMNLSEEVDL--EDYVARPDKISGADINSICQESGMLAVRENRYIVLAKD 398

Query: 545 FEYAVERVL 553
           FE A + V+
Sbjct: 399 FEKAYKTVI 407


>gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]
          Length = 750

 Score =  169 bits (429), Expect = 7e-42
 Identities = 97/230 (42%), Positives = 133/230 (57%), Gaps = 9/230 (3%)

Query: 306 VSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATE 365
           V F+DV G      EV + + +++ PE +  LG   P+G LL GPPGCGKTLLA A+A E
Sbjct: 156 VKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGE 215

Query: 366 AQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFS 425
             +P L +A PE V  + G    ++R LF++A + APCI++IDEIDA+  KR       S
Sbjct: 216 LDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVA----S 271

Query: 426 NTEEEQTLNQLLVEMD---GMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTL 482
              E + + QLL  MD    +  T  V+V+ +TNR D LD AL R GR DR + + +P  
Sbjct: 272 KDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDE 331

Query: 483 QERREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHA 532
             R  I +   + L+L Q+  F    LA LTPGF GAD+  +C EAA+ A
Sbjct: 332 ASRERILQTLCRKLRLPQAFDFC--HLAHLTPGFVGADLMALCREAAMCA 379



 Score =  160 bits (404), Expect = 6e-39
 Identities = 95/279 (34%), Positives = 160/279 (57%), Gaps = 19/279 (6%)

Query: 306 VSFKDVAGMHEAKLEVR-EFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVAT 364
           V++ D+  + + + E+    +  +++P++F  LG   P G LL GPPGCGKTLLAKAVA 
Sbjct: 472 VTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVAN 531

Query: 365 EAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGF 424
           E+ + F+++ GPE + +  G     VR +F+ A+  APC+++ DE+DA+  +RS   +G 
Sbjct: 532 ESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGA 591

Query: 425 SNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQE 484
           S     + +NQLL EMDG+     V ++A+TNR DI+D A++RPGRLD+ +F+ LP   +
Sbjct: 592 S----VRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPAD 647

Query: 485 RREIFEQHLKS-LKLTQSSTFYSQRLAE--LTPGFSGADIANICNEAALHAARE------ 535
           R  I +   K+  K    +    + +A       ++GAD++ +  EA++ A R+      
Sbjct: 648 RLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQK 707

Query: 536 -----GHTSVHTLNFEYAVERVLAGTAKKSKILSKEEQK 569
                G   V   +FE A ++V +  +KK +I+ +  Q+
Sbjct: 708 SGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYERLQE 746


>gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]
          Length = 856

 Score =  169 bits (429), Expect = 7e-42
 Identities = 97/230 (42%), Positives = 133/230 (57%), Gaps = 9/230 (3%)

Query: 306 VSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATE 365
           V F+DV G      EV + + +++ PE +  LG   P+G LL GPPGCGKTLLA A+A E
Sbjct: 262 VKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGE 321

Query: 366 AQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFS 425
             +P L +A PE V  + G    ++R LF++A + APCI++IDEIDA+  KR       S
Sbjct: 322 LDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVA----S 377

Query: 426 NTEEEQTLNQLLVEMD---GMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTL 482
              E + + QLL  MD    +  T  V+V+ +TNR D LD AL R GR DR + + +P  
Sbjct: 378 KDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDE 437

Query: 483 QERREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHA 532
             R  I +   + L+L Q+  F    LA LTPGF GAD+  +C EAA+ A
Sbjct: 438 ASRERILQTLCRKLRLPQAFDFC--HLAHLTPGFVGADLMALCREAAMCA 485



 Score =  160 bits (404), Expect = 6e-39
 Identities = 95/279 (34%), Positives = 160/279 (57%), Gaps = 19/279 (6%)

Query: 306 VSFKDVAGMHEAKLEVR-EFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVAT 364
           V++ D+  + + + E+    +  +++P++F  LG   P G LL GPPGCGKTLLAKAVA 
Sbjct: 578 VTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVAN 637

Query: 365 EAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGF 424
           E+ + F+++ GPE + +  G     VR +F+ A+  APC+++ DE+DA+  +RS   +G 
Sbjct: 638 ESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGA 697

Query: 425 SNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQE 484
           S     + +NQLL EMDG+     V ++A+TNR DI+D A++RPGRLD+ +F+ LP   +
Sbjct: 698 S----VRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPAD 753

Query: 485 RREIFEQHLKS-LKLTQSSTFYSQRLAE--LTPGFSGADIANICNEAALHAARE------ 535
           R  I +   K+  K    +    + +A       ++GAD++ +  EA++ A R+      
Sbjct: 754 RLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQK 813

Query: 536 -----GHTSVHTLNFEYAVERVLAGTAKKSKILSKEEQK 569
                G   V   +FE A ++V +  +KK +I+ +  Q+
Sbjct: 814 SGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYERLQE 852


>gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]
          Length = 439

 Score =  165 bits (418), Expect = 1e-40
 Identities = 100/256 (39%), Positives = 147/256 (57%), Gaps = 13/256 (5%)

Query: 308 FKDVAGMHEAKLEVREFVDYLKSP----ERFLQLGAKVPKGALLLGPPGCGKTLLAKAVA 363
           + D+ G+ +   +++E V+ +  P    E+F  LG + PKG L+ GPPG GKTLLA+A A
Sbjct: 185 YSDIGGLDK---QIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACA 241

Query: 364 TEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSG 423
            + +  FL +AGP+ V++  G GA  VR  F  A+ +AP I++IDE+DA+G KR  +   
Sbjct: 242 AQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKA 301

Query: 424 FSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQ 483
             + E ++T+ +LL ++DG      V V+A+TNR DILD AL+R GRLDR +   +P  +
Sbjct: 302 -GDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEE 360

Query: 484 ERREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSVHTL 543
            R  I + H  S K+  S     + LA  T  F+GA    +C EA + A R G T    L
Sbjct: 361 ARARIMQIH--SRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATE---L 415

Query: 544 NFEYAVERVLAGTAKK 559
             E  +E +L   AKK
Sbjct: 416 THEDYMEGILEVQAKK 431


>gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]
          Length = 753

 Score =  156 bits (395), Expect = 6e-38
 Identities = 95/283 (33%), Positives = 158/283 (55%), Gaps = 25/283 (8%)

Query: 286 AFNQLKMARFTIVDGKMG-KGVSFKDVAGMHEAKLEVREFVDY-LKSPERFLQLGAKVPK 343
           AF  ++ + F  V G M  K V ++++ G+ + KL++++ +++ LK P  F+++G   PK
Sbjct: 440 AFKNIQPSSFRSVIGLMDIKPVDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPK 499

Query: 344 GALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPC 403
           G LL GPPGC KT L +A+AT     F++++G +      G     +  +F++ARA  P 
Sbjct: 500 GVLLYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPA 559

Query: 404 IVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDGMGT------------------ 445
           I+++DEID++   RS + +G     +E+ L+ LL E+DG+G                   
Sbjct: 560 ILFLDEIDSILGARSASKTGCD--VQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEV 617

Query: 446 -TDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQERREIFEQHLKSLKLTQSSTF 504
               V+++A+TNR D+LD AL+RPGRLD+ ++I  P  + R  I +   K++ +    + 
Sbjct: 618 FNRSVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVSL 677

Query: 505 YSQRLAELTPGFSGADIANICNEAALHAAREGHTSVHTLNFEY 547
             + LA  T  FSGAD+ N+C EAAL A +E      T+  E+
Sbjct: 678 --ENLAAETCFFSGADLRNLCTEAALLALQENGLDATTVKQEH 718



 Score =  145 bits (365), Expect = 2e-34
 Identities = 90/226 (39%), Positives = 128/226 (56%), Gaps = 12/226 (5%)

Query: 311 VAGMHEAKLEVREFVDY-LKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVP 369
           + G+ EA   +RE +   L+ P     LG  VP+G LL GPPG GKT L +AVA EA   
Sbjct: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAE 261

Query: 370 FLAMAGPEFVEVIGGLGAARVRSLFKEAR---ARAPCIVYIDEIDAVGKKRSTTMSGFSN 426
            LA++ P       G     VR +F+ AR   +R P ++++DE+DA+  +R       S 
Sbjct: 262 LLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQRG------SR 315

Query: 427 TEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQERR 486
             E + + Q+L  +DG      V+V+ +TNR D LD AL RPGR DR V I  PTL++R+
Sbjct: 316 APESRVVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRK 375

Query: 487 EIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHA 532
           EI +  + + K+  SS      LAE+T G+ GAD+  +C EAA+HA
Sbjct: 376 EILQ--VITSKMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHA 419


>gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]
          Length = 980

 Score =  154 bits (390), Expect = 2e-37
 Identities = 94/250 (37%), Positives = 136/250 (54%), Gaps = 5/250 (2%)

Query: 286 AFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGA 345
           A  QL+ A    V       VS+ DV G+ E K E+ E +         L LG +   G 
Sbjct: 682 ALEQLQTAHSQAVGAPKIPSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLR-RSGL 740

Query: 346 LLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIV 405
           LL GPPG GKTLLAKAVATE  + FL++ GPE + +  G     VR +F  ARA APCI+
Sbjct: 741 LLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCII 800

Query: 406 YIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGAL 465
           + DE+D++   R    SG S    ++ ++QLL E+DG+ +T  V V+ +TNR D+LD AL
Sbjct: 801 FFDELDSLAPSRG--RSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPAL 858

Query: 466 MRPGRLDRHVFIDL-PTLQERREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANI 524
           +RPGR D+ VF+        +  +     +  KL  S +  +  L    P  +GAD+ ++
Sbjct: 859 LRPGRFDKLVFVGANEDRASQLRVLSAITRKFKLEPSVSLVNV-LDCCPPQLTGADLYSL 917

Query: 525 CNEAALHAAR 534
           C++A   A +
Sbjct: 918 CSDAMTAALK 927



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 30/116 (25%), Positives = 54/116 (46%), Gaps = 3/116 (2%)

Query: 346 LLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIV 405
           LL GPPGCGKT +  A  +   +  L +          G    +++++F  AR   P ++
Sbjct: 467 LLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVL 526

Query: 406 YIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADIL 461
            +  +D +G+ R        +      L  LL+  D + +   ++V+A+T+RA  L
Sbjct: 527 LLTAVDLLGRDRDGL---GEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDL 579


>gi|4505725 peroxin1 [Homo sapiens]
          Length = 1283

 Score =  137 bits (345), Expect = 4e-32
 Identities = 80/230 (34%), Positives = 126/230 (54%), Gaps = 7/230 (3%)

Query: 304  KGVSFKDVAGMHEAKLEVREFVDY-LKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAV 362
            + + +  + G+HE +  + + +    K PE F  L  +   G LL GPPG GKTLLA  +
Sbjct: 835  RDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVI 894

Query: 363  ATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMS 422
            A E+++ F+++ GPE +    G     VR +F  A+A  PCI++ DE +++  +R    +
Sbjct: 895  ARESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNT 954

Query: 423  GFSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTL 482
            G +    ++ +NQLL ++DG+     V VLA+T+R D++D AL+RPGRLD+ V+   P  
Sbjct: 955  GVT----DRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQ 1010

Query: 483  QERREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHA 532
              R EI      SL L        Q +A +T  F+GAD+  +   A L A
Sbjct: 1011 VSRLEILNVLSDSLPLADDVDL--QHVASVTDSFTGADLKALLYNAQLEA 1058



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 69/308 (22%), Positives = 126/308 (40%), Gaps = 46/308 (14%)

Query: 333 RFLQLGAKVPKGALLL-GPPGCGKTLLAKAVATEA---------QVPFLAMAGPEFVEVI 382
           + + L A +  GALLL G  G GK+ LAKA+  EA         +V   A+ G     + 
Sbjct: 582 QLMSLVAGLRNGALLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKRLENIQ 641

Query: 383 GGLGAARVRSLFKEARARAPCIVYIDEIDAVG-----KKRSTTMSGFSNTEEEQTLNQLL 437
             L  A     F EA    P +V +D++D +       +   +     +      LN ++
Sbjct: 642 KTLEVA-----FSEAVWMQPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMI 696

Query: 438 VEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVF-----IDLPTLQERREIFEQH 492
            E   MG+   V ++A++     L   L+    +  H+F     I  P  ++R EI    
Sbjct: 697 KEFISMGSL--VALIATSQSQQSLHPLLVSAQGV--HIFQCVQHIQPPNQEQRCEILCNV 752

Query: 493 LKS---LKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHA--AREGHTS-----VHT 542
           +K+     + + +    Q +A+ T GF   D   +  + A+H+  +R+  ++     + T
Sbjct: 753 IKNKLDCDINKFTDLDLQHVAKETGGFVARDF-TVLVDRAIHSRLSRQSISTREKLVLTT 811

Query: 543 LNFEYAVERVLAGTAKKSKILSKEE---QKVVAFHESGHALVGWM---LEHTEAVMKVSI 596
           L+F+ A+   L  + +   +    +    K+   HE    L+  +    ++ E    + I
Sbjct: 812 LDFQKALRGFLPASLRSVNLHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPI 871

Query: 597 TPRTNAAL 604
             RT   L
Sbjct: 872 RQRTGILL 879


>gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]
          Length = 1390

 Score =  135 bits (340), Expect = 1e-31
 Identities = 85/248 (34%), Positives = 128/248 (51%), Gaps = 11/248 (4%)

Query: 301 KMGKGVSFKDVAGMHEAKLEVREFVDY-LKSPERFLQLGAKVPKGALLLGPPGCGKTLLA 359
           ++   V F  V G+      ++E V + L  PE F +   + P+G L  GPPG GKTL+A
Sbjct: 418 QLDSSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVA 477

Query: 360 KAVATEA-----QVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVG 414
           +A+A E      +V F    G + +    G    ++R LF +A    P I++ DEID + 
Sbjct: 478 RALANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLA 537

Query: 415 KKRSTTMSGFSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRH 474
             RS+      ++     ++ LL  MDG+ +   ++V+ +TNR D +D AL RPGR DR 
Sbjct: 538 PVRSSRQDQIHSS----IVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDRE 593

Query: 475 VFIDLPTLQERREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAR 534
               LP  + R+EI + H +        TF  + LAE   G+ GADI +IC EAAL A R
Sbjct: 594 FLFSLPDKEARKEILKIHTRDWNPKPLDTFL-EELAENCVGYCGADIKSICAEAALCALR 652

Query: 535 EGHTSVHT 542
             +  ++T
Sbjct: 653 RRYPQIYT 660


>gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]
          Length = 1458

 Score =  131 bits (330), Expect = 2e-30
 Identities = 90/288 (31%), Positives = 141/288 (48%), Gaps = 18/288 (6%)

Query: 304 KGVSFKDVAGMHEAKLEVREFVDY-LKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAV 362
           K V F  + G+      ++E V + L  PE F +   + P+G L  GPPG GKTL+A+A+
Sbjct: 395 KSVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARAL 454

Query: 363 ATEA-----QVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKR 417
           A E      +V F    G + +    G    ++R LF +A    P I++ DEID +   R
Sbjct: 455 ANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVR 514

Query: 418 STTMSGFSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFI 477
           S+      ++     ++ LL  MDG+     ++V+ +TNR D +D AL RPGR DR    
Sbjct: 515 SSRQDQIHSS----IVSTLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLF 570

Query: 478 DLPTLQERREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAREGH 537
           +LP  + R+ I + H +      S  F  + LAE   G+ GADI  +C EAAL A R  +
Sbjct: 571 NLPDQKARKHILQIHTRDWNPKLSDAFLGE-LAEKCVGYCGADIKALCTEAALIALRRRY 629

Query: 538 TSVHTLNFEYAVERVLAGTAKKSKILSKEEQKVV-----AFHESGHAL 580
             ++  + +  ++  ++     ++      Q +V     A   SGHAL
Sbjct: 630 PQIYASSHKLQLD--VSSIVLSAQDFYHAMQNIVPASQRAVMSSGHAL 675


>gi|5901990 katanin p60 subunit A 1 [Homo sapiens]
          Length = 491

 Score =  130 bits (327), Expect = 5e-30
 Identities = 98/271 (36%), Positives = 144/271 (53%), Gaps = 33/271 (12%)

Query: 306 VSFKDVAGMHEAKLEVREFVDY-LKSPERFLQLGAKVP-KGALLLGPPGCGKTLLAKAVA 363
           V + D+A + EAK  ++E V   +  PE F   G + P KG L++GPPG GKTLLAKAVA
Sbjct: 206 VRWDDIADLVEAKKLLKEAVVLPMWMPEFFK--GIRRPWKGVLMVGPPGTGKTLLAKAVA 263

Query: 364 TEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSG 423
           TE +  F  ++         G     VR LF+ AR  +P  ++IDEID++  +R T+   
Sbjct: 264 TECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSE-- 321

Query: 424 FSNTEEEQTLNQLLVEMDGMGTTDH-------VIVLASTNRADILDGALMRPGRLDRHVF 476
             +    +   +LLV+MDG+G T         V+VLA+TN    +D AL R  RL++ ++
Sbjct: 322 -EHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIY 378

Query: 477 IDLPTLQERREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAREG 536
           I LP+ + R E+    L+ L+L       S  +AE   G+SGADI N+C +A+L A R  
Sbjct: 379 IPLPSAKGREELLRISLRELELADDVDLAS--IAENMEGYSGADITNVCRDASLMAMR-- 434

Query: 537 HTSVHTLNFEYAVERVLAGTAKKSKILSKEE 567
                         R+   T ++ + LSKEE
Sbjct: 435 -------------RRIEGLTPEEIRNLSKEE 452


>gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  127 bits (320), Expect = 3e-29
 Identities = 84/236 (35%), Positives = 131/236 (55%), Gaps = 14/236 (5%)

Query: 306 VSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATE 365
           + + D+A + EAK  +RE V        F +   +  KG L++GPPG GKT+LAKAVATE
Sbjct: 205 IHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAVATE 264

Query: 366 AQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFS 425
               F  ++         G     VR LF+ AR  AP  ++IDEID++  +R T+     
Sbjct: 265 CGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTS---DE 321

Query: 426 NTEEEQTLNQLLVEMDGMG-------TTDHVIVLASTNRADILDGALMRPGRLDRHVFID 478
           +    +  ++LL++MDG+G        +  V+VLA+TN    +D AL R  RL++ ++I 
Sbjct: 322 HEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIP 379

Query: 479 LPTLQERREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAR 534
           LPT + R E+ + +L+ ++L        + +AE   G+SGADI N+C +A+L A R
Sbjct: 380 LPTAKGRAELLKINLREVEL--DPDIQLEDIAEKIEGYSGADITNVCRDASLMAMR 433


>gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  127 bits (320), Expect = 3e-29
 Identities = 84/236 (35%), Positives = 131/236 (55%), Gaps = 14/236 (5%)

Query: 306 VSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATE 365
           + + D+A + EAK  +RE V        F +   +  KG L++GPPG GKT+LAKAVATE
Sbjct: 205 IHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAVATE 264

Query: 366 AQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFS 425
               F  ++         G     VR LF+ AR  AP  ++IDEID++  +R T+     
Sbjct: 265 CGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTS---DE 321

Query: 426 NTEEEQTLNQLLVEMDGMG-------TTDHVIVLASTNRADILDGALMRPGRLDRHVFID 478
           +    +  ++LL++MDG+G        +  V+VLA+TN    +D AL R  RL++ ++I 
Sbjct: 322 HEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIP 379

Query: 479 LPTLQERREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAR 534
           LPT + R E+ + +L+ ++L        + +AE   G+SGADI N+C +A+L A R
Sbjct: 380 LPTAKGRAELLKINLREVEL--DPDIQLEDIAEKIEGYSGADITNVCRDASLMAMR 433


>gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens]
          Length = 466

 Score =  127 bits (318), Expect = 5e-29
 Identities = 89/241 (36%), Positives = 137/241 (56%), Gaps = 20/241 (8%)

Query: 306 VSFKDVAGMHEAKLEVREFVDYLKSPERFLQL--GAKVP-KGALLLGPPGCGKTLLAKAV 362
           + + D+ G+  AK  V+E V Y   P R+ QL  G   P KG LL GPPG GKTLLAKAV
Sbjct: 179 IKWNDIIGLDAAKQLVKEAVVY---PIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAV 235

Query: 363 ATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMS 422
           ATE +  F  ++    V    G     VR LF+ AR  AP  +++DE+++V  +R T   
Sbjct: 236 ATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASG 295

Query: 423 GFSNTEEEQTL---NQLLVEMDGMG-TTDHVIVLASTNRADILDGALMRPGRLDRHVFID 478
           G    E E +L    +LLV+MDG+  + D V VLA++N    LD A++R  RL++ + +D
Sbjct: 296 G----EHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLR--RLEKRILVD 349

Query: 479 LPTLQERREIFEQHLKSLKLTQSSTFYSQR----LAELTPGFSGADIANICNEAALHAAR 534
           LP+ + R+ +    L  +  +++   +++     L++ T G+SG+DI  +C EAA+   R
Sbjct: 350 LPSREARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVR 409

Query: 535 E 535
           +
Sbjct: 410 K 410


>gi|169167838 PREDICTED: similar to hCG2002932 [Homo sapiens]
          Length = 415

 Score =  125 bits (313), Expect = 2e-28
 Identities = 79/249 (31%), Positives = 127/249 (51%), Gaps = 18/249 (7%)

Query: 307 SFKDVAGMHEAKLEVREFVDY-LKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATE 365
           ++ +  G+     E++E ++  L  PE + ++G K PKG +L GPPG             
Sbjct: 170 TYVNTGGLDNQIQEIKESMELPLPHPEYYEEMGTKPPKGVILCGPPGTAT---------- 219

Query: 366 AQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFS 425
               FL + G E ++   G G   VR +F+ A   AP I++ DEI+A+G KR  + SG  
Sbjct: 220 ----FLRVVGSELIQKYLGDGPKLVRQVFQVAEEHAPSIMFTDEIEAIGTKRYDSNSGGE 275

Query: 426 NTEEEQTLN-QLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQE 484
              ++  L  +LL ++ G  + + V V+ +T + + LD  L+RPGR+D+ +   LP  + 
Sbjct: 276 REIQQTMLELELLNQLGGFDSREDVKVIMATKQVETLDPVLIRPGRIDKKIEFHLPDEKT 335

Query: 485 RREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSVHTLN 544
           ++ IF+ H   + L    T     +A+    FSGADI  IC EA L A RE        +
Sbjct: 336 KKHIFQIHTSRMTLANDVTLDDLIMAK--DDFSGADIKAICTEAGLMALREHRMKATNED 393

Query: 545 FEYAVERVL 553
           F+ ++E VL
Sbjct: 394 FKKSIESVL 402


>gi|239748566 PREDICTED: similar to hCG2002932 [Homo sapiens]
          Length = 415

 Score =  125 bits (313), Expect = 2e-28
 Identities = 79/249 (31%), Positives = 127/249 (51%), Gaps = 18/249 (7%)

Query: 307 SFKDVAGMHEAKLEVREFVDY-LKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATE 365
           ++ +  G+     E++E ++  L  PE + ++G K PKG +L GPPG             
Sbjct: 170 TYVNTGGLDNQIQEIKESMELPLPHPEYYEEMGTKPPKGVILCGPPGTAT---------- 219

Query: 366 AQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFS 425
               FL + G E ++   G G   VR +F+ A   AP I++ DEI+A+G KR  + SG  
Sbjct: 220 ----FLRVVGSELIQKYLGDGPKLVRQVFQVAEEHAPSIMFTDEIEAIGTKRYDSNSGGE 275

Query: 426 NTEEEQTLN-QLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQE 484
              ++  L  +LL ++ G  + + V V+ +T + + LD  L+RPGR+D+ +   LP  + 
Sbjct: 276 REIQQTMLELELLNQLGGFDSREDVKVIMATKQVETLDPVLIRPGRIDKKIEFHLPDEKT 335

Query: 485 RREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSVHTLN 544
           ++ IF+ H   + L    T     +A+    FSGADI  IC EA L A RE        +
Sbjct: 336 KKHIFQIHTSRMTLANDVTLDDLIMAK--DDFSGADIKAICTEAGLMALREHRMKATNED 393

Query: 545 FEYAVERVL 553
           F+ ++E VL
Sbjct: 394 FKKSIESVL 402


>gi|239742549 PREDICTED: hypothetical protein LOC345645 [Homo
           sapiens]
          Length = 415

 Score =  125 bits (313), Expect = 2e-28
 Identities = 79/249 (31%), Positives = 127/249 (51%), Gaps = 18/249 (7%)

Query: 307 SFKDVAGMHEAKLEVREFVDY-LKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATE 365
           ++ +  G+     E++E ++  L  PE + ++G K PKG +L GPPG             
Sbjct: 170 TYVNTGGLDNQIQEIKESMELPLPHPEYYEEMGTKPPKGVILCGPPGTAT---------- 219

Query: 366 AQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFS 425
               FL + G E ++   G G   VR +F+ A   AP I++ DEI+A+G KR  + SG  
Sbjct: 220 ----FLRVVGSELIQKYLGDGPKLVRQVFQVAEEHAPSIMFTDEIEAIGTKRYDSNSGGE 275

Query: 426 NTEEEQTLN-QLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQE 484
              ++  L  +LL ++ G  + + V V+ +T + + LD  L+RPGR+D+ +   LP  + 
Sbjct: 276 REIQQTMLELELLNQLGGFDSREDVKVIMATKQVETLDPVLIRPGRIDKKIEFHLPDEKT 335

Query: 485 RREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSVHTLN 544
           ++ IF+ H   + L    T     +A+    FSGADI  IC EA L A RE        +
Sbjct: 336 KKHIFQIHTSRMTLANDVTLDDLIMAK--DDFSGADIKAICTEAGLMALREHRMKATNED 393

Query: 545 FEYAVERVL 553
           F+ ++E VL
Sbjct: 394 FKKSIESVL 402


>gi|40806170 spastin isoform 2 [Homo sapiens]
          Length = 584

 Score =  118 bits (296), Expect = 2e-26
 Identities = 88/245 (35%), Positives = 128/245 (52%), Gaps = 19/245 (7%)

Query: 297 IVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVP-KGALLLGPPGCGK 355
           IVD   G  V F D+AG   AK  ++E V  L S    L  G + P +G LL GPPG GK
Sbjct: 300 IVDN--GTAVKFDDIAGQDLAKQALQEIV-ILPSLRPELFTGLRAPARGLLLFGPPGNGK 356

Query: 356 TLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGK 415
           T+LAKAVA E+   F  ++         G G   VR+LF  AR   P I++IDE+D++  
Sbjct: 357 TMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLC 416

Query: 416 KRSTTMSGFSNTEEEQTLNQLLVEMDGMGTT--DHVIVLASTNRADILDGALMRPGRLDR 473
           +R        +    +   + L+E DG+ +   D V+V+ +TNR   LD A++R  R  +
Sbjct: 417 ERREG----EHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIK 470

Query: 474 HVFIDLPTLQERREIFEQHLKSLKLTQSSTFYSQRLAEL---TPGFSGADIANICNEAAL 530
            V++ LP  + R  +    LK+L   Q S    + LA+L   T G+SG+D+  +  +AAL
Sbjct: 471 RVYVSLPNEETRLLL----LKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAAL 526

Query: 531 HAARE 535
              RE
Sbjct: 527 GPIRE 531


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,275,972
Number of Sequences: 37866
Number of extensions: 1532032
Number of successful extensions: 13069
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 126
Number of HSP's successfully gapped in prelim test: 96
Number of HSP's that attempted gapping in prelim test: 10700
Number of HSP's gapped (non-prelim): 2146
length of query: 795
length of database: 18,247,518
effective HSP length: 110
effective length of query: 685
effective length of database: 14,082,258
effective search space: 9646346730
effective search space used: 9646346730
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.