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Search of human proteins with 4502427
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502427 bone morphogenetic protein 7 precursor [Homo
sapiens]
(431 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens] 887 0.0
gi|10835091 bone morphogenetic protein 5 preproprotein [Homo sap... 565 e-161
gi|4502425 bone morphogenetic protein 6 preproprotein [Homo sapi... 536 e-152
gi|145611428 bone morphogenetic protein 8A [Homo sapiens] 394 e-110
gi|29571106 bone morphogenetic protein 8B preproprotein [Homo sa... 392 e-109
gi|4557369 bone morphogenetic protein 2 preproprotein [Homo sapi... 191 8e-49
gi|157276597 bone morphogenetic protein 4 preproprotein [Homo sa... 189 4e-48
gi|157276595 bone morphogenetic protein 4 preproprotein [Homo sa... 189 4e-48
gi|157276593 bone morphogenetic protein 4 preproprotein [Homo sa... 189 4e-48
gi|4503969 growth differentiation factor 5 preproprotein [Homo s... 140 2e-33
gi|7656928 bone morphogenetic protein 10 preproprotein [Homo sap... 139 6e-33
gi|48475062 growth differentiation factor 6 precursor [Homo sapi... 138 8e-33
gi|61835232 growth differentiation factor 7 preproprotein [Homo ... 133 3e-31
gi|10190670 growth differentiation factor 3 precursor [Homo sapi... 128 1e-29
gi|7705308 growth differentiation factor 2 [Homo sapiens] 121 1e-27
gi|110349792 growth differentiation factor 1 [Homo sapiens] 119 5e-27
gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sa... 113 3e-25
gi|4826740 growth differentiation factor 10 precursor [Homo sapi... 112 6e-25
gi|222352098 nodal precursor [Homo sapiens] 102 5e-22
gi|4507465 transforming growth factor, beta 3 [Homo sapiens] 102 9e-22
gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo ... 101 1e-21
gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo sa... 101 1e-21
gi|4504699 inhibin beta A precursor [Homo sapiens] 100 3e-21
gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens] 100 4e-21
gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens] 96 6e-20
gi|4885259 myostatin [Homo sapiens] 94 3e-19
gi|13899338 activin beta E [Homo sapiens] 90 3e-18
gi|5031613 growth differentiation factor 11 precursor [Homo sapi... 87 2e-17
gi|4885261 growth differentiation factor 9 precursor [Homo sapiens] 84 3e-16
gi|5031795 inhibin beta C chain preproprotein [Homo sapiens] 84 3e-16
>gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]
Length = 431
Score = 887 bits (2292), Expect = 0.0
Identities = 431/431 (100%), Positives = 431/431 (100%)
Query: 1 MHVRSLRAAAPHSFVALWAPLFLLRSALADFSLDNEVHSSFIHRRLRSQERREMQREILS 60
MHVRSLRAAAPHSFVALWAPLFLLRSALADFSLDNEVHSSFIHRRLRSQERREMQREILS
Sbjct: 1 MHVRSLRAAAPHSFVALWAPLFLLRSALADFSLDNEVHSSFIHRRLRSQERREMQREILS 60
Query: 61 ILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEEGGGPGGQGFSYPYKAVFSTQGPPLAS 120
ILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEEGGGPGGQGFSYPYKAVFSTQGPPLAS
Sbjct: 61 ILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEEGGGPGGQGFSYPYKAVFSTQGPPLAS 120
Query: 121 LQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHHREFRFDLSKIPEGEAVTAAEFRIYKDY 180
LQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHHREFRFDLSKIPEGEAVTAAEFRIYKDY
Sbjct: 121 LQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHHREFRFDLSKIPEGEAVTAAEFRIYKDY 180
Query: 181 IRERFDNETFRISVYQVLQEHLGRESDLFLLDSRTLWASEEGWLVFDITATSNHWVVNPR 240
IRERFDNETFRISVYQVLQEHLGRESDLFLLDSRTLWASEEGWLVFDITATSNHWVVNPR
Sbjct: 181 IRERFDNETFRISVYQVLQEHLGRESDLFLLDSRTLWASEEGWLVFDITATSNHWVVNPR 240
Query: 241 HNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPFMVAFFKATEVHFRSIRSTGSKQRS 300
HNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPFMVAFFKATEVHFRSIRSTGSKQRS
Sbjct: 241 HNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPFMVAFFKATEVHFRSIRSTGSKQRS 300
Query: 301 QNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCE 360
QNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCE
Sbjct: 301 QNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCE 360
Query: 361 GECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVILKKY 420
GECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVILKKY
Sbjct: 361 GECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVILKKY 420
Query: 421 RNMVVRACGCH 431
RNMVVRACGCH
Sbjct: 421 RNMVVRACGCH 431
>gi|10835091 bone morphogenetic protein 5 preproprotein [Homo
sapiens]
Length = 454
Score = 565 bits (1457), Expect = e-161
Identities = 281/426 (65%), Positives = 339/426 (79%), Gaps = 30/426 (7%)
Query: 34 DNEVHSSFIHRRLRSQERREMQREILSILGLPHRPRPHLQGKH-NSAPMFMLDLYNAMAV 92
DN VHSSFI+RRLR+ ERRE+QREILSILGLPHRPRP GK +SAP+FMLDLYNAM
Sbjct: 31 DNHVHSSFIYRRLRNHERREIQREILSILGLPHRPRPFSPGKQASSAPLFMLDLYNAMTN 90
Query: 93 EEG---------------------GGPGGQGFSYPYKAVFS------TQGPPLASLQDSH 125
EE G P YP + S TQ PPLASL D++
Sbjct: 91 EENPEESEYSVRASLAEETRGARKGYPASPN-GYPRRIQLSRTTPLTTQSPPLASLHDTN 149
Query: 126 FLTDADMVMSFVNLVEHDKEFFHPRYHHREFRFDLSKIPEGEAVTAAEFRIYKDYIRERF 185
FL DADMVMSFVNLVE DK+F H R H++EFRFDL++IP GEAVTAAEFRIYKD RF
Sbjct: 150 FLNDADMVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRF 209
Query: 186 DNETFRISVYQVLQEHLGRESDLFLLDSRTLWASEEGWLVFDITATSNHWVVNPRHNLGL 245
+NET +IS+YQ+++E+ R++DLFLLD+R A + GWLVFDIT TSNHWV+NP++NLGL
Sbjct: 210 ENETIKISIYQIIKEYTNRDADLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGL 269
Query: 246 QLSVETLDGQSINPKLAGLIGRHGPQNKQPFMVAFFKATEVHFRSIRSTGSKQRSQNRSK 305
QL ET DG+SIN K AGL+GR GPQ+KQPFMVAFFKA+EV RS+R+ +K+++QNR+K
Sbjct: 270 QLCAETGDGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRA-ANKRKNQNRNK 328
Query: 306 TPKNQEALRMANVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAF 365
+ +Q++ RM++V + ++S+Q+QACKKHELYVSFRDLGWQDWIIAPEGYAA+YC+GEC+F
Sbjct: 329 SSSHQDSSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSF 388
Query: 366 PLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVV 425
PLN++MNATNHAIVQTLVH + P+ VPKPCCAPT+LNAISVLYFDDSSNVILKKYRNMVV
Sbjct: 389 PLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVV 448
Query: 426 RACGCH 431
R+CGCH
Sbjct: 449 RSCGCH 454
>gi|4502425 bone morphogenetic protein 6 preproprotein [Homo
sapiens]
Length = 513
Score = 536 bits (1381), Expect = e-152
Identities = 269/450 (59%), Positives = 334/450 (74%), Gaps = 57/450 (12%)
Query: 39 SSFIHRRLRSQERREMQREILSILGLPHRPRP--HLQ----------------------- 73
S F++RRL++QE+REMQ+EILS+LGLPHRPRP LQ
Sbjct: 64 SGFLYRRLKTQEKREMQKEILSVLGLPHRPRPLHGLQQPQPPALRQQEEQQQQQQLPRGE 123
Query: 74 ---GKHNSAPMFMLDLYNAMAV---EEGGGPGGQGFSYPYKAVFSTQ------------- 114
G+ SAP+FMLDLYNA++ E+G G + S+P++A S+Q
Sbjct: 124 PPPGRLKSAPLFMLDLYNALSADNDEDGASEGERQQSWPHEAASSSQRRQPPPGAAHPLN 183
Query: 115 -------------GPPLASLQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHHREFRFDLS 161
PL S QDS FL DADMVMSFVNLVE+DKEF + HH+EF+F+LS
Sbjct: 184 RKSLLAPGSGSGGASPLTSAQDSAFLNDADMVMSFVNLVEYDKEFSPRQRHHKEFKFNLS 243
Query: 162 KIPEGEAVTAAEFRIYKDYIRERFDNETFRISVYQVLQEHLGRESDLFLLDSRTLWASEE 221
+IPEGE VTAAEFRIYKD + F N+TF IS+YQVLQEH R+SDLFLLD+R +WASEE
Sbjct: 244 QIPEGEVVTAAEFRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWASEE 303
Query: 222 GWLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPFMVAFF 281
GWL FDITATSN WVV P+HN+GLQLSV T DG ++P+ AGL+GR GP +KQPFMVAFF
Sbjct: 304 GWLEFDITATSNLWVVTPQHNMGLQLSVVTRDGVHVHPRAAGLVGRDGPYDKQPFMVAFF 363
Query: 282 KATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYVSFRD 341
K +EVH R+ RS S++R Q+R+++ ++Q+ R+++ ++ +SS+ + AC+KHELYVSF+D
Sbjct: 364 KVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVSFQD 423
Query: 342 LGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQL 401
LGWQDWIIAP+GYAA YC+GEC+FPLN++MNATNHAIVQTLVH +NPE VPKPCCAPT+L
Sbjct: 424 LGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKL 483
Query: 402 NAISVLYFDDSSNVILKKYRNMVVRACGCH 431
NAISVLYFDD+SNVILKKYRNMVVRACGCH
Sbjct: 484 NAISVLYFDDNSNVILKKYRNMVVRACGCH 513
>gi|145611428 bone morphogenetic protein 8A [Homo sapiens]
Length = 402
Score = 394 bits (1012), Expect = e-110
Identities = 207/395 (52%), Positives = 274/395 (69%), Gaps = 33/395 (8%)
Query: 44 RRLRSQERREMQREILSILGLPHRPRPHLQGKHN----SAPMFMLDLYNAMAVE--EGGG 97
RRL ++ERR++QREIL++LGLP RPRP + SAP+FMLDLY+AMA + E G
Sbjct: 34 RRLGARERRDVQREILAVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDEDGA 93
Query: 98 PGGQGFSYPYKAVFSTQGPPLASLQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHHREFR 157
P Q L AD+VMSFVN+VE D+ H H +EFR
Sbjct: 94 PAEQR------------------------LGRADLVMSFVNMVERDRALGHQEPHWKEFR 129
Query: 158 FDLSKIPEGEAVTAAEFRIYKDYIRERFDNETFRISVYQVLQEHLGRESDLFLLDSRTLW 217
FDL++IP GEAVTAAEFRIYK N T +S++QV+QE RESDLF LD +TL
Sbjct: 130 FDLTQIPAGEAVTAAEFRIYK-VPSIHLLNRTLHVSMFQVVQEQSNRESDLFFLDLQTLR 188
Query: 218 ASEEGWLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPFM 277
A +EGWLV D+TA S+ W++ +LGL+L VET DG S++P LAGL+G+ P+++QPF+
Sbjct: 189 AGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRAPRSQQPFV 248
Query: 278 VAFFKATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAEN-SSSDQRQACKKHELY 336
V FF+A+ R+ R+ +R Q + K+ + +A R+ + ++ S RQ C++HELY
Sbjct: 249 VTFFRASPSPIRTPRAVRPLRRRQPK-KSNELPQANRLPGIFDDVRGSHGRQVCRRHELY 307
Query: 337 VSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCC 396
VSF+DLGW DW+IAP+GY+AYYCEGEC+FPL+S MNATNHAI+Q+LVH + P VPK CC
Sbjct: 308 VSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMKPNAVPKACC 367
Query: 397 APTQLNAISVLYFDDSSNVILKKYRNMVVRACGCH 431
APT+L+A SVLY+D S+NVIL+K+RNMVV+ACGCH
Sbjct: 368 APTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH 402
>gi|29571106 bone morphogenetic protein 8B preproprotein [Homo
sapiens]
Length = 402
Score = 392 bits (1008), Expect = e-109
Identities = 206/395 (52%), Positives = 275/395 (69%), Gaps = 33/395 (8%)
Query: 44 RRLRSQERREMQREILSILGLPHRPRPHLQGKHN----SAPMFMLDLYNAMAVE--EGGG 97
RRL ++ERR++QREIL++LGLP RPRP + SAP+FMLDLY+AMA + E G
Sbjct: 34 RRLGARERRDVQREILAVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDEDGA 93
Query: 98 PGGQGFSYPYKAVFSTQGPPLASLQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHHREFR 157
P + L AD+VMSFVN+VE D+ H H +EFR
Sbjct: 94 PAERR------------------------LGRADLVMSFVNMVERDRALGHQEPHWKEFR 129
Query: 158 FDLSKIPEGEAVTAAEFRIYKDYIRERFDNETFRISVYQVLQEHLGRESDLFLLDSRTLW 217
FDL++IP GEAVTAAEFRIYK N T +S++QV+QE RESDLF LD +TL
Sbjct: 130 FDLTQIPAGEAVTAAEFRIYK-VPSIHLLNRTLHVSMFQVVQEQSNRESDLFFLDLQTLR 188
Query: 218 ASEEGWLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPFM 277
A +EGWLV D+TA S+ W++ +LGL+L VET DG S++P LAGL+G+ P+++QPF+
Sbjct: 189 AGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRAPRSQQPFV 248
Query: 278 VAFFKATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAEN-SSSDQRQACKKHELY 336
V FF+A+ R+ R+ +R Q + K+ + +A R+ + ++ S RQ C++HELY
Sbjct: 249 VTFFRASPSPIRTPRAVRPLRRRQPK-KSNELPQANRLPGIFDDVHGSHGRQVCRRHELY 307
Query: 337 VSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCC 396
VSF+DLGW DW+IAP+GY+AYYCEGEC+FPL+S MNATNHAI+Q+LVH + P+ VPK CC
Sbjct: 308 VSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMMPDAVPKACC 367
Query: 397 APTQLNAISVLYFDDSSNVILKKYRNMVVRACGCH 431
APT+L+A SVLY+D S+NVIL+K+RNMVV+ACGCH
Sbjct: 368 APTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH 402
>gi|4557369 bone morphogenetic protein 2 preproprotein [Homo
sapiens]
Length = 396
Score = 191 bits (486), Expect = 8e-49
Identities = 126/392 (32%), Positives = 187/392 (47%), Gaps = 62/392 (15%)
Query: 53 EMQREILSILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEEGGGPGGQGFSYPYKAVFS 112
E + +LS+ GL RP P + P +MLDLY G PG + + S
Sbjct: 52 EFELRLLSMFGLKQRPTP---SRDAVVPPYMLDLYR----RHSGQPGSPAPDHRLERAAS 104
Query: 113 TQGPPLASLQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHHREFRFDLSKIPEGEAVTAA 172
A+ V SF + ++ R F F+LS IP E +T+A
Sbjct: 105 R----------------ANTVRSFHHEESLEELPETSGKTTRRFFFNLSSIPTEEFITSA 148
Query: 173 EFRIYKDYIRERFDNET---FRISVYQVLQEHLGRESDLF--LLDSRTLWASEEGWLVFD 227
E +++++ +++ N + RI++Y++++ LLD+R + + W FD
Sbjct: 149 ELQVFREQMQDALGNNSSFHHRINIYEIIKPATANSKFPVTRLLDTRLVNQNASRWESFD 208
Query: 228 ITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGR------HGPQNKQPFMVAFF 281
+T W N G + V L+ + K I R H +P +V F
Sbjct: 209 VTPAVMRWTAQGHANHGFVVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFG 268
Query: 282 ---KATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYVS 338
K +H R R KQR + +S +CK+H LYV
Sbjct: 269 HDGKGHPLHKREKRQAKHKQRKRLKS------------------------SCKRHPLYVD 304
Query: 339 FRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAP 398
F D+GW DWI+AP GY A+YC GEC FPL ++N+TNHAIVQTLV+ +N + +PK CC P
Sbjct: 305 FSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSK-IPKACCVP 363
Query: 399 TQLNAISVLYFDDSSNVILKKYRNMVVRACGC 430
T+L+AIS+LY D++ V+LK Y++MVV CGC
Sbjct: 364 TELSAISMLYLDENEKVVLKNYQDMVVEGCGC 395
>gi|157276597 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 189 bits (480), Expect = 4e-48
Identities = 128/393 (32%), Positives = 192/393 (48%), Gaps = 54/393 (13%)
Query: 52 REMQREILSILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEEGGGP-GGQGFSYPYKAV 110
R+ + +L + GL RP+P K P +M DLY + EE G YP +
Sbjct: 55 RDFEATLLQMFGLRRRPQP---SKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPA 111
Query: 111 FSTQGPPLASLQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHHREFRF--DLSKIPEGEA 168
+ A+ V SF + E E + FRF +LS IPE E
Sbjct: 112 -----------------SRANTVRSFHH--EEHLENIPGTSENSAFRFLFNLSSIPENEV 152
Query: 169 VTAAEFRIYKDYIRERFDNET--FRISVYQVLQ---EHLGRESDLFLLDSRTLWASEEGW 223
+++AE R++++ + + D E RI++Y+V++ E + LLD+R + + W
Sbjct: 153 ISSAELRLFREQVDQGPDWERGFHRINIYEVMKPPAEVVPGHLITRLLDTRLVHHNVTRW 212
Query: 224 LVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNK------QPFM 277
FD++ W + N GL + V L + I R PQ +P +
Sbjct: 213 ETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPLL 272
Query: 278 VAFFKATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYV 337
V F H + ++R RS +Q A + + + C++H LYV
Sbjct: 273 VTFGHDGRGHALT------RRRRAKRSPKHHSQRARK-----------KNKNCRRHSLYV 315
Query: 338 SFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCA 397
F D+GW DWI+AP GY A+YC G+C FPL ++N+TNHAIVQTLV+ +N ++PK CC
Sbjct: 316 DFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCV 374
Query: 398 PTQLNAISVLYFDDSSNVILKKYRNMVVRACGC 430
PT+L+AIS+LY D+ V+LK Y+ MVV CGC
Sbjct: 375 PTELSAISMLYLDEYDKVVLKNYQEMVVEGCGC 407
>gi|157276595 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 189 bits (480), Expect = 4e-48
Identities = 128/393 (32%), Positives = 192/393 (48%), Gaps = 54/393 (13%)
Query: 52 REMQREILSILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEEGGGP-GGQGFSYPYKAV 110
R+ + +L + GL RP+P K P +M DLY + EE G YP +
Sbjct: 55 RDFEATLLQMFGLRRRPQP---SKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPA 111
Query: 111 FSTQGPPLASLQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHHREFRF--DLSKIPEGEA 168
+ A+ V SF + E E + FRF +LS IPE E
Sbjct: 112 -----------------SRANTVRSFHH--EEHLENIPGTSENSAFRFLFNLSSIPENEV 152
Query: 169 VTAAEFRIYKDYIRERFDNET--FRISVYQVLQ---EHLGRESDLFLLDSRTLWASEEGW 223
+++AE R++++ + + D E RI++Y+V++ E + LLD+R + + W
Sbjct: 153 ISSAELRLFREQVDQGPDWERGFHRINIYEVMKPPAEVVPGHLITRLLDTRLVHHNVTRW 212
Query: 224 LVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNK------QPFM 277
FD++ W + N GL + V L + I R PQ +P +
Sbjct: 213 ETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPLL 272
Query: 278 VAFFKATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYV 337
V F H + ++R RS +Q A + + + C++H LYV
Sbjct: 273 VTFGHDGRGHALT------RRRRAKRSPKHHSQRARK-----------KNKNCRRHSLYV 315
Query: 338 SFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCA 397
F D+GW DWI+AP GY A+YC G+C FPL ++N+TNHAIVQTLV+ +N ++PK CC
Sbjct: 316 DFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCV 374
Query: 398 PTQLNAISVLYFDDSSNVILKKYRNMVVRACGC 430
PT+L+AIS+LY D+ V+LK Y+ MVV CGC
Sbjct: 375 PTELSAISMLYLDEYDKVVLKNYQEMVVEGCGC 407
>gi|157276593 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 189 bits (480), Expect = 4e-48
Identities = 128/393 (32%), Positives = 192/393 (48%), Gaps = 54/393 (13%)
Query: 52 REMQREILSILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEEGGGP-GGQGFSYPYKAV 110
R+ + +L + GL RP+P K P +M DLY + EE G YP +
Sbjct: 55 RDFEATLLQMFGLRRRPQP---SKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPA 111
Query: 111 FSTQGPPLASLQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHHREFRF--DLSKIPEGEA 168
+ A+ V SF + E E + FRF +LS IPE E
Sbjct: 112 -----------------SRANTVRSFHH--EEHLENIPGTSENSAFRFLFNLSSIPENEV 152
Query: 169 VTAAEFRIYKDYIRERFDNET--FRISVYQVLQ---EHLGRESDLFLLDSRTLWASEEGW 223
+++AE R++++ + + D E RI++Y+V++ E + LLD+R + + W
Sbjct: 153 ISSAELRLFREQVDQGPDWERGFHRINIYEVMKPPAEVVPGHLITRLLDTRLVHHNVTRW 212
Query: 224 LVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNK------QPFM 277
FD++ W + N GL + V L + I R PQ +P +
Sbjct: 213 ETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPLL 272
Query: 278 VAFFKATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYV 337
V F H + ++R RS +Q A + + + C++H LYV
Sbjct: 273 VTFGHDGRGHALT------RRRRAKRSPKHHSQRARK-----------KNKNCRRHSLYV 315
Query: 338 SFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCA 397
F D+GW DWI+AP GY A+YC G+C FPL ++N+TNHAIVQTLV+ +N ++PK CC
Sbjct: 316 DFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCV 374
Query: 398 PTQLNAISVLYFDDSSNVILKKYRNMVVRACGC 430
PT+L+AIS+LY D+ V+LK Y+ MVV CGC
Sbjct: 375 PTELSAISMLYLDEYDKVVLKNYQEMVVEGCGC 407
>gi|4503969 growth differentiation factor 5 preproprotein [Homo
sapiens]
Length = 501
Score = 140 bits (353), Expect = 2e-33
Identities = 96/314 (30%), Positives = 169/314 (53%), Gaps = 25/314 (7%)
Query: 130 ADMVMSFVNLVEHDKEFFHPRYHHREFRFDLSKIPEGEAVTAAEFRIYKDYIRERFDNET 189
A+ + SF++ + D+ P + + FD+S + E + + AE RI + +
Sbjct: 199 ANTITSFIDKGQDDRG---PVVRKQRYVFDISAL-EKDGLLGAELRILRKKPSDTAKPAA 254
Query: 190 ---FRISVYQVLQEHLGRESDLFLLDSRTLWASE-EGWLVFDITATSNHWVV--NPRHNL 243
R + ++ GR+ LLD R++ + GW VFDI W + N +++
Sbjct: 255 PGGGRAAQLKLSSCPSGRQP-ASLLDVRSVPGLDGSGWEVFDI------WKLFRNFKNSA 307
Query: 244 GLQLSVETLD-GQSINPKLAGLIGRHGPQNKQPFMVAF--FKATEVHFRSIRSTGSKQRS 300
L L +E + G++++ + G +++ + F K ++ F I++ S Q
Sbjct: 308 QLCLELEAWERGRAVDLRGLGFDRAARQVHEKALFLVFGRTKKRDLFFNEIKAR-SGQDD 366
Query: 301 QNRSKTPKNQEALRMANVA----ENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAA 356
+ + +Q R A +A + S + + C + L+V+F+D+GW DWIIAP Y A
Sbjct: 367 KTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEA 426
Query: 357 YYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVI 416
++CEG C FPL S++ TNHA++QTL++ ++PE+ P CC PT+L+ IS+L+ D ++NV+
Sbjct: 427 FHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVV 486
Query: 417 LKKYRNMVVRACGC 430
K+Y +MVV +CGC
Sbjct: 487 YKQYEDMVVESCGC 500
>gi|7656928 bone morphogenetic protein 10 preproprotein [Homo
sapiens]
Length = 424
Score = 139 bits (349), Expect = 6e-33
Identities = 105/401 (26%), Positives = 168/401 (41%), Gaps = 55/401 (13%)
Query: 52 REMQREILSILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEEGGGPGGQGFSYPYKAVF 111
+ M+ E L L L P P +ML+LYN A + P
Sbjct: 56 QSMKDEFLKTLNLSDIPTQ--DSAKVDPPEYMLELYNKFATDRTSMPS------------ 101
Query: 112 STQGPPLASLQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHHREFRFDLSKIPEGEAVTA 171
A+++ SF N + F++S IP E V
Sbjct: 102 ------------------ANIIRSFKNEDLFSQPVSFNGLRKYPLLFNVS-IPHHEEVIM 142
Query: 172 AEFRIYKDYIRER--FDNETFRISVYQVLQEHLGRESD--LFLLDSRTLWASEEGWLVFD 227
AE R+Y R+R +D +I++++VL+ E + + +L S ++ + W FD
Sbjct: 143 AELRLYTLVQRDRMIYDGVDRKITIFEVLESKGDNEGERNMLVLVSGEIYGTNSEWETFD 202
Query: 228 ITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPFMVAFFKATEVH 287
+T W + L++ +E+ ++ + L QNK ++ F +
Sbjct: 203 VTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSGRLEIDTSAQNKHNPLLIVFSDDQSS 262
Query: 288 FRSIRSTGSKQRSQNR------------SKTPKNQEALRM-ANVAENSSSDQRQA----- 329
+ + ++ S + S P + L+M +N+ +S++ R+
Sbjct: 263 DKERKEELNEMISHEQLPELDNLGLDSFSSGPGEEALLQMRSNIIYDSTARIRRNAKGNY 322
Query: 330 CKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPE 389
CK+ LY+ F+++GW WIIAP GY AY C G C +PL ++ T HAI+Q LVH N +
Sbjct: 323 CKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQ 382
Query: 390 TVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGC 430
K CC PT+L IS+LY D KY M V CGC
Sbjct: 383 KASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGC 423
>gi|48475062 growth differentiation factor 6 precursor [Homo
sapiens]
Length = 455
Score = 138 bits (348), Expect = 8e-33
Identities = 103/344 (29%), Positives = 151/344 (43%), Gaps = 56/344 (16%)
Query: 130 ADMVMSFVNLVEHDKEFFHPRYHHREFRFDLSKIPEGEAVTAAEFRIYKDYIRERFDNET 189
A+ + SFV+ D H +++ FD+S + + E + AE R+++ +
Sbjct: 124 ANTITSFVDRGLDDLS--HTPLRRQKYLFDVSMLSDKEELVGAELRLFRQAPSAPWGPPA 181
Query: 190 --FRISVYQVLQEHLGRESDLFLLDSRTL---WASEEGWLVFDITATSNHWVVNPRHNLG 244
+ ++ L LLD+RTL A GW VFD+ H P L
Sbjct: 182 GPLHVQLFPCLSP--------LLLDARTLDPQGAPPAGWEVFDVWQGLRH---QPWKQLC 230
Query: 245 LQLSVE--TLDG-----------QSINPKLAGL-IGRH-GPQNKQPFMVAF--------F 281
L+L LD Q P L L GR P ++ +V F F
Sbjct: 231 LELRAAWGELDAGEAEARARGPQQPPPPDLRSLGFGRRVRPPQERALLVVFTRSQRKNLF 290
Query: 282 KATEVHFRSIRSTGSKQRSQNRSKTPKNQEALR---------------MANVAENSSSDQ 326
S + G ++ P R + +
Sbjct: 291 AEMREQLGSAEAAGPGAGAEGSWPPPSGAPDARPWLPSPGRRRRRTAFASRHGKRHGKKS 350
Query: 327 RQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFI 386
R C K L+V+F++LGW DWIIAP Y AY+CEG C FPL S++ TNHAI+QTL++ +
Sbjct: 351 RLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSM 410
Query: 387 NPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGC 430
+P + P CC PT+L IS+LY D +NV+ K+Y +MVV +CGC
Sbjct: 411 DPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGC 454
>gi|61835232 growth differentiation factor 7 preproprotein [Homo
sapiens]
Length = 450
Score = 133 bits (335), Expect = 3e-31
Identities = 55/104 (52%), Positives = 75/104 (72%)
Query: 327 RQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFI 386
R C + L+V F++LGW DWIIAP Y AY+CEG C FPL S++ TNHAI+QTL++ +
Sbjct: 346 RSRCSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNSM 405
Query: 387 NPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGC 430
P+ P CC P +L+ IS+LY D ++NV+ K+Y +MVV ACGC
Sbjct: 406 APDAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGC 449
>gi|10190670 growth differentiation factor 3 precursor [Homo
sapiens]
Length = 364
Score = 128 bits (321), Expect = 1e-29
Identities = 86/280 (30%), Positives = 143/280 (51%), Gaps = 34/280 (12%)
Query: 158 FDLSKIPEGEAVTAAEFRIYKDYIRERFDN--ETFRISVYQVLQEHLGRESD-----LFL 210
F+LS I E E +T A+ + D + N ++++ V + H+ ++ +F+
Sbjct: 111 FNLSAIKEREQLTLAQLGL--DLGPNSYYNLGPELELALFLVQEPHVWGQTTPKPGKMFV 168
Query: 211 LDSRTLWASEEGWLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGP 270
L S W +G + F++ + W NPR N GL L + + R
Sbjct: 169 LRS-VPWP--QGAVHFNLLDVAKDWNDNPRKNFGLFLEILVKED------------RDSG 213
Query: 271 QNKQPFMVAFFKATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAENSSSDQRQAC 330
N QP +H + T + + + K + A+ + ++ + C
Sbjct: 214 VNFQPEDTCARLRCSLHASLLVVTLNPDQCH---PSRKRRAAIPVPKLS------CKNLC 264
Query: 331 KKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPET 390
+H+L+++FRDLGW WIIAP+G+ A YC GEC F L +N++N+A +Q L+H ++PE
Sbjct: 265 HRHQLFINFRDLGWHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHAVDPE- 323
Query: 391 VPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGC 430
+P+ C PT+L+ IS+LY D++ NVIL+ Y +MVV CGC
Sbjct: 324 IPQAVCIPTKLSPISMLYQDNNDNVILRHYEDMVVDECGC 363
>gi|7705308 growth differentiation factor 2 [Homo sapiens]
Length = 429
Score = 121 bits (304), Expect = 1e-27
Identities = 115/400 (28%), Positives = 174/400 (43%), Gaps = 69/400 (17%)
Query: 59 LSILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEEGGGPGGQGFSYPYKAVFSTQGPPL 118
L++ G+P + + ++ P +M+DLYN Y + ST P
Sbjct: 70 LNLSGVPSQDKTRVE-----PPQYMIDLYNR-----------------YTSDKSTT--PA 105
Query: 119 ASLQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHHREFRFDLSKIPEGEAVTAAEFRIY- 177
+++ S + DA + + E F + H F IP E +T AE R+Y
Sbjct: 106 SNIVRSFSMEDAISITA--------TEDFPFQKHILLFNIS---IPRHEQITRAELRLYV 154
Query: 178 --KDYIRERFDNETFRISVYQVLQEHLGRESDLFLLDSRTLWASE----EGWLVFDITAT 231
++++ D + + +Y VL G ++ +++T S+ EGW ++++
Sbjct: 155 SCQNHVDPSHDLKG-SVVIYDVLD---GTDAWDSATETKTFLVSQDIQDEGWETLEVSSA 210
Query: 232 SNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPFMVAFF-------KAT 284
WV + +L V T++ + G +N PF V F K T
Sbjct: 211 VKRWVRSDSTKSKNKLEV-TVESHRKGCDTLDISVPPGSRNL-PFFVVFSNDHSSGTKET 268
Query: 285 EVHFRSIRSTGSKQRSQNRSKTPKNQ------EALRMANVAENSSSDQRQA-------CK 331
+ R + S + + SK + E +VA S+ +R+ C+
Sbjct: 269 RLELREMISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQ 328
Query: 332 KHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETV 391
K L V+F D+GW WIIAP+ Y AY C+G C FPL + T HAIVQTLVH P V
Sbjct: 329 KTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKV 388
Query: 392 PKPCCAPTQLNAISVLYFDDSSNVILK-KYRNMVVRACGC 430
K CC PT+L+ ISVLY DD LK Y M V CGC
Sbjct: 389 GKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGC 428
>gi|110349792 growth differentiation factor 1 [Homo sapiens]
Length = 372
Score = 119 bits (298), Expect = 5e-27
Identities = 51/106 (48%), Positives = 72/106 (67%), Gaps = 4/106 (3%)
Query: 329 ACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPL----NSYMNATNHAIVQTLVH 384
AC+ LYVSFR++GW W+IAP G+ A YC+G+CA P+ + A NHA+++ L+H
Sbjct: 266 ACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMH 325
Query: 385 FINPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGC 430
P PCC P +L+ ISVL+FD+S NV+L++Y +MVV CGC
Sbjct: 326 AAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGC 371
>gi|126507087 bone morphogenetic protein 3 preproprotein [Homo
sapiens]
Length = 472
Score = 113 bits (283), Expect = 3e-25
Identities = 49/135 (36%), Positives = 79/135 (58%), Gaps = 1/135 (0%)
Query: 297 KQRSQNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAA 356
KQR K+ Q + A + + C + L V F D+GW +WII+P+ + A
Sbjct: 337 KQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDA 396
Query: 357 YYCEGECAFPLNSYMNATNHAIVQTLVHFIN-PETVPKPCCAPTQLNAISVLYFDDSSNV 415
YYC G C FP+ + +NHA +Q++V + +P+PCC P +++++S+L+FD++ NV
Sbjct: 397 YYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNV 456
Query: 416 ILKKYRNMVVRACGC 430
+LK Y NM V +C C
Sbjct: 457 VLKVYPNMTVESCAC 471
>gi|4826740 growth differentiation factor 10 precursor [Homo
sapiens]
Length = 478
Score = 112 bits (280), Expect = 6e-25
Identities = 51/146 (34%), Positives = 79/146 (54%), Gaps = 12/146 (8%)
Query: 297 KQRSQNRSKTPKNQEALRMANV-----------AENSSSDQRQACKKHELYVSFRDLGWQ 345
K R + + K QE A+ A D+ + C + L V F D+GW
Sbjct: 332 KPRPGRKDRRKKGQEVFMAASQVLDFDEKTMQKARRKQWDEPRVCSRRYLKVDFADIGWN 391
Query: 346 DWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFIN-PETVPKPCCAPTQLNAI 404
+WII+P+ + AYYC G C FP+ + +NHA +Q++V + +P+PCC P ++N++
Sbjct: 392 EWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIIPGIPEPCCVPDKMNSL 451
Query: 405 SVLYFDDSSNVILKKYRNMVVRACGC 430
VL+ D++ NV+LK Y NM V C C
Sbjct: 452 GVLFLDENRNVVLKVYPNMSVDTCAC 477
>gi|222352098 nodal precursor [Homo sapiens]
Length = 347
Score = 102 bits (255), Expect = 5e-22
Identities = 77/294 (26%), Positives = 126/294 (42%), Gaps = 41/294 (13%)
Query: 156 FRFDLSKIPEGEAVTAAEFRIYKDYIRERFDNETFRISVYQVLQEHLGRESDL----FLL 211
F FD S + + E + AE R+ + + I ++ + + SD F +
Sbjct: 75 FAFDFSFLSQQEDLAWAELRLQLSSPVDLPTEGSLAIEIFHQPKPDTEQASDSCLERFQM 134
Query: 212 DSRTLWASEE----GWLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGR 267
D T+ S+ G +V ++T + W+ +P ++ +++ + G
Sbjct: 135 DLFTVTLSQVTFSLGSMVLEVTRPLSKWLKHPG---------------ALEKQMSRVAGE 179
Query: 268 HGPQNKQPFMVAFFKATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAENSSS--- 324
P+ P AT V + +QR S E+ A + S
Sbjct: 180 CWPRPPTP------PATNVLLMLYSNLSQEQRQLGGSTLLWEAESSWRAQEGQLSWEWGK 233
Query: 325 --------DQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNH 376
D+ Q C+K + V F +GW WII P+ Y AY CEGEC P+ + TNH
Sbjct: 234 RHRRHHLPDRSQLCRKVKFQVDFNLIGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNH 293
Query: 377 AIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGC 430
A +Q+L+ P VP CCAP + +S+LY D+ V+L +++M+V CGC
Sbjct: 294 AYIQSLLKRYQPHRVPSTCCAPVKTKPLSMLYV-DNGRVLLDHHKDMIVEECGC 346
>gi|4507465 transforming growth factor, beta 3 [Homo sapiens]
Length = 412
Score = 102 bits (253), Expect = 9e-22
Identities = 105/440 (23%), Positives = 182/440 (41%), Gaps = 70/440 (15%)
Query: 21 LFLLRSALADFSLDNEVHSSFIHRRLRSQERREMQREILSILGLPHRPRPHLQGKHNSAP 80
L LL A SL F H ++ + ++ +ILS L L P P + P
Sbjct: 12 LALLNFATVSLSLSTCTTLDFGH--IKKKRVEAIRGQILSKLRLTSPPEPTVM---THVP 66
Query: 81 MFMLDLYNAMA--VEEGGGPGGQGFSYPYKAVFSTQGPPLASLQDSHFLTDADMVMSFVN 138
+L LYN+ +EE G +G + + + ++ +
Sbjct: 67 YQVLALYNSTRELLEEMHGEREEGCTQE-------------NTESEYYAKEIHKFDMIQG 113
Query: 139 LVEHDKEFFHPR-YHHREFRFDLSKIPEGEA-VTAAEFRIYKDYIRERFDNETFRISVYQ 196
L EH++ P+ + FRF++S + + + AEFR+ + NE RI ++Q
Sbjct: 114 LAEHNELAVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQ-RIELFQ 172
Query: 197 VLQ--EHLGRESDLFLLDSRTLWASEEGWLVFDITATSNHWVVNPRHNLGLQLSVETLDG 254
+L+ EH+ ++ + + T +E WL FD+T T W++ NLGL++S+
Sbjct: 173 ILRPDEHIAKQRYIGGKNLPTRGTAE--WLSFDVTDTVREWLLRRESNLGLEISIHC--- 227
Query: 255 QSINPKLAGLIGRHGPQNKQPFMVAFFKATEVHFRSIRSTGSKQRSQ----NRSKTPKNQ 310
H Q + + E+ F+ + + R + K N
Sbjct: 228 -----------PCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNP 276
Query: 311 EAL-------RMANVAENSSSDQR------------QACKKHELYVSFR-DLGWQDWIIA 350
+ R+ N + +R + C LY+ FR DLGW+ W+
Sbjct: 277 HLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWK-WVHE 335
Query: 351 PEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFD 410
P+GY A +C G C + ++ T H+ V L + +NPE PCC P L +++LY+
Sbjct: 336 PKGYYANFCSGPCPYLRSA---DTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYV 392
Query: 411 DSSNVILKKYRNMVVRACGC 430
+ + ++ NMVV++C C
Sbjct: 393 GRTPKV-EQLSNMVVKSCKC 411
>gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo
sapiens]
Length = 442
Score = 101 bits (251), Expect = 1e-21
Identities = 84/304 (27%), Positives = 141/304 (46%), Gaps = 31/304 (10%)
Query: 146 FFHPRYHHREFRFDLSKIPEGEA-VTAAEFRIYK-DYIRERFDNETFRISVYQVLQEHLG 203
F+ P + R RFD+S + + + + AEFR+++ + R + RI +YQ+L+
Sbjct: 150 FYRPYF--RIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQ--RIELYQILKSKDL 205
Query: 204 RESDLFLLDSRTLWASEEG-WLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLA 262
+DS+ + EG WL FD+T + W+ + NLG ++S+ + P
Sbjct: 206 TSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFV-PSNN 264
Query: 263 GLIGRHGPQNKQPFMVAFFKATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAENS 322
+I + + F A T + + T R +N KTP L + E+
Sbjct: 265 YIIPNKSEELEARF--AGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQ 322
Query: 323 SSDQRQA---------------CKKHELYVSF-RDLGWQDWIIAPEGYAAYYCEGECAFP 366
+++R+ C LY+ F RDLGW+ WI P+GY A +C G C +
Sbjct: 323 QTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGACPYL 381
Query: 367 LNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVR 426
+S T H+ V +L + INPE PCC L +++LY+ + I ++ NM+V+
Sbjct: 382 WSS---DTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI-EQLSNMIVK 437
Query: 427 ACGC 430
+C C
Sbjct: 438 SCKC 441
>gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo
sapiens]
Length = 414
Score = 101 bits (251), Expect = 1e-21
Identities = 84/304 (27%), Positives = 141/304 (46%), Gaps = 31/304 (10%)
Query: 146 FFHPRYHHREFRFDLSKIPEGEA-VTAAEFRIYK-DYIRERFDNETFRISVYQVLQEHLG 203
F+ P + R RFD+S + + + + AEFR+++ + R + RI +YQ+L+
Sbjct: 122 FYRPYF--RIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQ--RIELYQILKSKDL 177
Query: 204 RESDLFLLDSRTLWASEEG-WLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLA 262
+DS+ + EG WL FD+T + W+ + NLG ++S+ + P
Sbjct: 178 TSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFV-PSNN 236
Query: 263 GLIGRHGPQNKQPFMVAFFKATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAENS 322
+I + + F A T + + T R +N KTP L + E+
Sbjct: 237 YIIPNKSEELEARF--AGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQ 294
Query: 323 SSDQRQA---------------CKKHELYVSF-RDLGWQDWIIAPEGYAAYYCEGECAFP 366
+++R+ C LY+ F RDLGW+ WI P+GY A +C G C +
Sbjct: 295 QTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGACPYL 353
Query: 367 LNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVR 426
+S T H+ V +L + INPE PCC L +++LY+ + I ++ NM+V+
Sbjct: 354 WSS---DTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI-EQLSNMIVK 409
Query: 427 ACGC 430
+C C
Sbjct: 410 SCKC 413
>gi|4504699 inhibin beta A precursor [Homo sapiens]
Length = 426
Score = 100 bits (248), Expect = 3e-21
Identities = 48/109 (44%), Positives = 63/109 (57%), Gaps = 12/109 (11%)
Query: 330 CKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGEC--------AFPLNSYMNATNHAIVQT 381
C K + +VSF+D+GW DWIIAP GY A YCEGEC L+ + NH ++
Sbjct: 321 CCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRG 380
Query: 382 LVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGC 430
F N K CC PT+L +S+LY+DD N+I K +NM+V CGC
Sbjct: 381 HSPFAN----LKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGC 425
>gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]
Length = 392
Score = 99.8 bits (247), Expect = 4e-21
Identities = 50/161 (31%), Positives = 83/161 (51%), Gaps = 6/161 (3%)
Query: 276 FMVAFFKATEVHFRSIR--STGSKQRSQNRSKTPKNQEALRMANVAENSSSD----QRQA 329
F++ +F T R + G ++ + S + ++A ++ SSS +
Sbjct: 231 FLLLYFNDTHKSIRKAKFLPRGMEEFMERESLLRRTRQADGISAEVTASSSKHSGPENNQ 290
Query: 330 CKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPE 389
C H +SFR LGW WIIAP Y YC+G C L +N+ NHAI+Q L++ + +
Sbjct: 291 CSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVDQ 350
Query: 390 TVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGC 430
+VP+P C P + ISVL + + +++ K+Y M+ +C C
Sbjct: 351 SVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTC 391
>gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]
Length = 407
Score = 95.9 bits (237), Expect = 6e-20
Identities = 68/255 (26%), Positives = 105/255 (41%), Gaps = 39/255 (15%)
Query: 180 YIRERFDNETFRISVYQVLQEHLGRESDLFLLDSRTLWASEEGWLVFDITATSNHWVVNP 239
Y+ E+ R+ VY Q H D + + + + GW F +T
Sbjct: 187 YVLEKGSRRKVRVKVYFQEQGH----GDRWNMVEKRVDLKRSGWHTFPLTEAIQALFERG 242
Query: 240 RHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPFMVAFFKATEVHFRSIRSTGSKQR 299
L L + ++ ++ P G ++ +PF+V R S+ R
Sbjct: 243 ERRLNLDVQCDSCQELAVVPVFVD----PGEESHRPFVVV----------QARLGDSRHR 288
Query: 300 SQNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYC 359
+ R + L C + + ++ FR +GW DWIIAP GY YC
Sbjct: 289 IRKRGLECDGRTNL----------------CCRQQFFIDFRLIGWNDWIIAPTGYYGNYC 332
Query: 360 EGECAFPLNSYMNATN--HAIV--QTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSNV 415
EG C L + + H V Q + +NP TV CC PT+L+ +S+LYFDD N+
Sbjct: 333 EGSCPAYLAGVPGSASSFHTAVVNQYRMRGLNPGTV-NSCCIPTKLSTMSMLYFDDEYNI 391
Query: 416 ILKKYRNMVVRACGC 430
+ + NM+V CGC
Sbjct: 392 VKRDVPNMIVEECGC 406
>gi|4885259 myostatin [Homo sapiens]
Length = 375
Score = 93.6 bits (231), Expect = 3e-19
Identities = 63/208 (30%), Positives = 87/208 (41%), Gaps = 36/208 (17%)
Query: 223 WLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPFMVAFFK 282
W D+ +W+ P NLG+++ +G + G G PF+ K
Sbjct: 203 WQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPG----PGEDGLNPFLEV--K 256
Query: 283 ATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYVSFRDL 342
T+ RS R G + S++ R C ++ L V F
Sbjct: 257 VTDTPKRSRRDFGLD---------------------CDEHSTESR--CCRYPLTVDFEAF 293
Query: 343 GWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLN 402
GW DWIIAP+ Y A YC GEC F T+ LVH NP PCC PT+++
Sbjct: 294 GW-DWIIAPKRYKANYCSGECEFVFLQKYPHTH------LVHQANPRGSAGPCCTPTKMS 346
Query: 403 AISVLYFDDSSNVILKKYRNMVVRACGC 430
I++LYF+ +I K MVV CGC
Sbjct: 347 PINMLYFNGKEQIIYGKIPAMVVDRCGC 374
>gi|13899338 activin beta E [Homo sapiens]
Length = 350
Score = 90.1 bits (222), Expect = 3e-18
Identities = 61/191 (31%), Positives = 89/191 (46%), Gaps = 30/191 (15%)
Query: 243 LGLQLSVETLDGQS-INPKLAGLIGRHGPQNKQPFMVAFFKATEVHFRSIRSTGSKQRSQ 301
L LQL L+G S + + L+ G Q QPF+ +A E +
Sbjct: 186 LKLQLDCRPLEGNSTVTGQPRRLLDTAGHQ--QPFLELKIRANE-----------PGAGR 232
Query: 302 NRSKTPKNQEALRMANVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEG 361
R +TP + A + C + + YV F++LGW+DWI+ PEGY YC G
Sbjct: 233 ARRRTPTCEPATPL--------------CCRRDHYVDFQELGWRDWILQPEGYQLNYCSG 278
Query: 362 ECAFPL--NSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVILKK 419
+C L + + A+ H+ V +L+ NP CC PT +S+LY D + NV+
Sbjct: 279 QCPPHLAGSPGIAASFHSAVFSLLKANNPWPASTSCCVPTARRPLSLLYLDHNGNVVKTD 338
Query: 420 YRNMVVRACGC 430
+MVV ACGC
Sbjct: 339 VPDMVVEACGC 349
>gi|5031613 growth differentiation factor 11 precursor [Homo
sapiens]
Length = 407
Score = 87.4 bits (215), Expect = 2e-17
Identities = 60/208 (28%), Positives = 87/208 (41%), Gaps = 36/208 (17%)
Query: 223 WLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPFMVAFFK 282
W D + W P+ N G++++ G + G G + PFM
Sbjct: 235 WQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLG----PGAEGLHPFM----- 285
Query: 283 ATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYVSFRDL 342
R + +T +R+ + SS+ R C ++ L V F
Sbjct: 286 ----ELRVLENTKRSRRNLGLD--------------CDEHSSESR--CCRYPLTVDFEAF 325
Query: 343 GWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLN 402
GW DWIIAP+ Y A YC G+C + +M H LV NP PCC PT+++
Sbjct: 326 GW-DWIIAPKRYKANYCSGQCEY---MFMQKYPHT---HLVQQANPRGSAGPCCTPTKMS 378
Query: 403 AISVLYFDDSSNVILKKYRNMVVRACGC 430
I++LYF+D +I K MVV CGC
Sbjct: 379 PINMLYFNDKQQIIYGKIPGMVVDRCGC 406
>gi|4885261 growth differentiation factor 9 precursor [Homo sapiens]
Length = 454
Score = 83.6 bits (205), Expect = 3e-16
Identities = 54/268 (20%), Positives = 106/268 (39%), Gaps = 43/268 (16%)
Query: 202 LGRESDLFLLDSRTLWASEEGWLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKL 261
LGR F +S+ + + W+ D+T+ V + + ++ + ++ + Q +P
Sbjct: 190 LGRAPYSFTFNSQFEFGKKHKWIQIDVTSLLQPLVASNKRSIHMSINFTCMKDQLEHPSA 249
Query: 262 AGLIGRHGPQNKQPFMVAFFKATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAEN 321
G P ++ + T ++ S S + S+ P + +L V E
Sbjct: 250 QN--GLFNMTLVSPSLILYLNDTSA--QAYHSWYSLHYKRRPSQGPDQERSLSAYPVGEE 305
Query: 322 SSSDQRQA---------------------------------------CKKHELYVSFRDL 342
++ D R + C+ H+ +SF L
Sbjct: 306 AAEDGRSSHHRHRRGQETVSSELKKPLGPASFNLSEYFRQFLLPQNECELHDFRLSFSQL 365
Query: 343 GWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLN 402
W +WI+AP Y YC+G+C + + H +VQ +++ +VP+P C P + +
Sbjct: 366 KWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDSSVPRPSCVPAKYS 425
Query: 403 AISVLYFDDSSNVILKKYRNMVVRACGC 430
+SVL + ++ K+Y +M+ C C
Sbjct: 426 PLSVLTIEPDGSIAYKEYEDMIATKCTC 453
>gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]
Length = 352
Score = 83.6 bits (205), Expect = 3e-16
Identities = 41/105 (39%), Positives = 58/105 (55%), Gaps = 4/105 (3%)
Query: 330 CKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSY--MNATNHAIVQTLV--HF 385
C + E +V FR++GW DWII PEGYA +C G+C + + A+ H V L+ +
Sbjct: 247 CCRQEFFVDFREIGWHDWIIQPEGYAMNFCIGQCPLHIAGMPGIAASFHTAVLNLLKANT 306
Query: 386 INPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGC 430
T CC PT +S+LY+D SN++ +MVV ACGC
Sbjct: 307 AAGTTGGGSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEACGC 351
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.135 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,692,255
Number of Sequences: 37866
Number of extensions: 766497
Number of successful extensions: 2036
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 38
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 1939
Number of HSP's gapped (non-prelim): 52
length of query: 431
length of database: 18,247,518
effective HSP length: 105
effective length of query: 326
effective length of database: 14,271,588
effective search space: 4652537688
effective search space used: 4652537688
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.