Search of human proteins with 4502425

Search of human proteins with 4502425

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4502425 bone morphogenetic protein 6 preproprotein [Homo
sapiens]
         (513 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4502425 bone morphogenetic protein 6 preproprotein [Homo sapi...  1065   0.0  
gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]      536   e-152
gi|10835091 bone morphogenetic protein 5 preproprotein [Homo sap...   520   e-147
gi|29571106 bone morphogenetic protein 8B preproprotein [Homo sa...   380   e-105
gi|145611428 bone morphogenetic protein 8A [Homo sapiens]             380   e-105
gi|4557369 bone morphogenetic protein 2 preproprotein [Homo sapi...   186   4e-47
gi|157276597 bone morphogenetic protein 4 preproprotein [Homo sa...   185   1e-46
gi|157276595 bone morphogenetic protein 4 preproprotein [Homo sa...   185   1e-46
gi|157276593 bone morphogenetic protein 4 preproprotein [Homo sa...   185   1e-46
gi|10190670 growth differentiation factor 3 precursor [Homo sapi...   140   2e-33
gi|4503969 growth differentiation factor 5 preproprotein [Homo s...   137   3e-32
gi|48475062 growth differentiation factor 6 precursor [Homo sapi...   132   8e-31
gi|61835232 growth differentiation factor 7 preproprotein [Homo ...   129   5e-30
gi|7705308 growth differentiation factor 2 [Homo sapiens]             129   6e-30
gi|7656928 bone morphogenetic protein 10 preproprotein [Homo sap...   124   2e-28
gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sa...   120   4e-27
gi|110349792 growth differentiation factor 1 [Homo sapiens]           120   4e-27
gi|4826740 growth differentiation factor 10 precursor [Homo sapi...   108   2e-23
gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]     106   6e-23
gi|4504699 inhibin beta A precursor [Homo sapiens]                    103   5e-22
gi|4507465 transforming growth factor, beta 3 [Homo sapiens]          102   1e-21
gi|4885259 myostatin [Homo sapiens]                                   100   2e-21
gi|222352098 nodal precursor [Homo sapiens]                           100   3e-21
gi|5031613 growth differentiation factor 11 precursor [Homo sapi...    97   5e-20
gi|13899338 activin beta E [Homo sapiens]                              95   2e-19
gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo ...    93   7e-19
gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo sa...    93   7e-19
gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]       90   4e-18
gi|4885261 growth differentiation factor 9 precursor [Homo sapiens]    88   2e-17
gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]           82   9e-16

>gi|4502425 bone morphogenetic protein 6 preproprotein [Homo
           sapiens]
          Length = 513

 Score = 1065 bits (2753), Expect = 0.0
 Identities = 513/513 (100%), Positives = 513/513 (100%)

Query: 1   MPGLGRRAQWLCWWWGLLCSCCGPPPLRPPLPAAAAAAAGGQLLGDGGSPGRTEQPPPSP 60
           MPGLGRRAQWLCWWWGLLCSCCGPPPLRPPLPAAAAAAAGGQLLGDGGSPGRTEQPPPSP
Sbjct: 1   MPGLGRRAQWLCWWWGLLCSCCGPPPLRPPLPAAAAAAAGGQLLGDGGSPGRTEQPPPSP 60

Query: 61  QSSSGFLYRRLKTQEKREMQKEILSVLGLPHRPRPLHGLQQPQPPALRQQEEQQQQQQLP 120
           QSSSGFLYRRLKTQEKREMQKEILSVLGLPHRPRPLHGLQQPQPPALRQQEEQQQQQQLP
Sbjct: 61  QSSSGFLYRRLKTQEKREMQKEILSVLGLPHRPRPLHGLQQPQPPALRQQEEQQQQQQLP 120

Query: 121 RGEPPPGRLKSAPLFMLDLYNALSADNDEDGASEGERQQSWPHEAASSSQRRQPPPGAAH 180
           RGEPPPGRLKSAPLFMLDLYNALSADNDEDGASEGERQQSWPHEAASSSQRRQPPPGAAH
Sbjct: 121 RGEPPPGRLKSAPLFMLDLYNALSADNDEDGASEGERQQSWPHEAASSSQRRQPPPGAAH 180

Query: 181 PLNRKSLLAPGSGSGGASPLTSAQDSAFLNDADMVMSFVNLVEYDKEFSPRQRHHKEFKF 240
           PLNRKSLLAPGSGSGGASPLTSAQDSAFLNDADMVMSFVNLVEYDKEFSPRQRHHKEFKF
Sbjct: 181 PLNRKSLLAPGSGSGGASPLTSAQDSAFLNDADMVMSFVNLVEYDKEFSPRQRHHKEFKF 240

Query: 241 NLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWA 300
           NLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWA
Sbjct: 241 NLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWA 300

Query: 301 SEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTRDGVHVHPRAAGLVGRDGPYDKQPFMV 360
           SEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTRDGVHVHPRAAGLVGRDGPYDKQPFMV
Sbjct: 301 SEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTRDGVHVHPRAAGLVGRDGPYDKQPFMV 360

Query: 361 AFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVS 420
           AFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVS
Sbjct: 361 AFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVS 420

Query: 421 FQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAP 480
           FQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAP
Sbjct: 421 FQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAP 480

Query: 481 TKLNAISVLYFDDNSNVILKKYRNMVVRACGCH 513
           TKLNAISVLYFDDNSNVILKKYRNMVVRACGCH
Sbjct: 481 TKLNAISVLYFDDNSNVILKKYRNMVVRACGCH 513


>gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]
          Length = 431

 Score =  536 bits (1381), Expect = e-152
 Identities = 269/450 (59%), Positives = 334/450 (74%), Gaps = 57/450 (12%)

Query: 64  SGFLYRRLKTQEKREMQKEILSVLGLPHRPRPLHGLQQPQPPALRQQEEQQQQQQLPRGE 123
           S F++RRL++QE+REMQ+EILS+LGLPHRPRP   LQ                       
Sbjct: 39  SSFIHRRLRSQERREMQREILSILGLPHRPRP--HLQ----------------------- 73

Query: 124 PPPGRLKSAPLFMLDLYNALSADNDEDGASEGERQQSWPHEAASSSQRRQPPPGAAHPLN 183
              G+  SAP+FMLDLYNA++    E+G   G +  S+P++A  S+Q             
Sbjct: 74  ---GKHNSAPMFMLDLYNAMAV---EEGGGPGGQGFSYPYKAVFSTQ------------- 114

Query: 184 RKSLLAPGSGSGGASPLTSAQDSAFLNDADMVMSFVNLVEYDKEFSPRQRHHKEFKFNLS 243
                          PL S QDS FL DADMVMSFVNLVE+DKEF   + HH+EF+F+LS
Sbjct: 115 -------------GPPLASLQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHHREFRFDLS 161

Query: 244 QIPEGEVVTAAEFRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWASEE 303
           +IPEGE VTAAEFRIYKD +   F N+TF IS+YQVLQEH  R+SDLFLLD+R +WASEE
Sbjct: 162 KIPEGEAVTAAEFRIYKDYIRERFDNETFRISVYQVLQEHLGRESDLFLLDSRTLWASEE 221

Query: 304 GWLEFDITATSNLWVVTPQHNMGLQLSVVTRDGVHVHPRAAGLVGRDGPYDKQPFMVAFF 363
           GWL FDITATSN WVV P+HN+GLQLSV T DG  ++P+ AGL+GR GP +KQPFMVAFF
Sbjct: 222 GWLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPFMVAFF 281

Query: 364 KVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVSFQD 423
           K +EVH R+ RS  S++R Q+R+++ ++Q+  R+++ ++ +SS+ + AC+KHELYVSF+D
Sbjct: 282 KATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYVSFRD 341

Query: 424 LGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKL 483
           LGWQDWIIAP+GYAA YC+GEC+FPLN++MNATNHAIVQTLVH +NPE VPKPCCAPT+L
Sbjct: 342 LGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQL 401

Query: 484 NAISVLYFDDNSNVILKKYRNMVVRACGCH 513
           NAISVLYFDD+SNVILKKYRNMVVRACGCH
Sbjct: 402 NAISVLYFDDSSNVILKKYRNMVVRACGCH 431


>gi|10835091 bone morphogenetic protein 5 preproprotein [Homo
           sapiens]
          Length = 454

 Score =  520 bits (1338), Expect = e-147
 Identities = 266/450 (59%), Positives = 328/450 (72%), Gaps = 31/450 (6%)

Query: 64  SGFLYRRLKTQEKREMQKEILSVLGLPHRPRPLHGLQQPQPPALRQQEEQQQQQQLPRGE 123
           S F+YRRL+  E+RE+Q+EILS+LGLPHRPRP                            
Sbjct: 36  SSFIYRRLRNHERREIQREILSILGLPHRPRPFS-------------------------- 69

Query: 124 PPPGRLKSAPLFMLDLYNALSADNDEDGASEGERQQSWPHEAASSSQRRQPPPGAAHPLN 183
            P  +  SAPLFMLDLYNA++  N+E+        ++   E    +++  P     +P  
Sbjct: 70  -PGKQASSAPLFMLDLYNAMT--NEENPEESEYSVRASLAEETRGARKGYPASPNGYP-R 125

Query: 184 RKSLLAPGSGSGGASPLTSAQDSAFLNDADMVMSFVNLVEYDKEFSPRQRHHKEFKFNLS 243
           R  L      +  + PL S  D+ FLNDADMVMSFVNLVE DK+FS ++RH+KEF+F+L+
Sbjct: 126 RIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEFRFDLT 185

Query: 244 QIPEGEVVTAAEFRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWASEE 303
           QIP GE VTAAEFRIYKD     F+N+T  ISIYQ+++E+ +RD+DLFLLDTR   A + 
Sbjct: 186 QIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDTRKAQALDV 245

Query: 304 GWLEFDITATSNLWVVTPQHNMGLQLSVVTRDGVHVHPRAAGLVGRDGPYDKQPFMVAFF 363
           GWL FDIT TSN WV+ PQ+N+GLQL   T DG  ++ ++AGLVGR GP  KQPFMVAFF
Sbjct: 246 GWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPFMVAFF 305

Query: 364 KVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVSFQD 423
           K SEV +R+ R+A+ +R+ Q+RN+S+  QD +R+SS  DYN+SE K AC+KHELYVSF+D
Sbjct: 306 KASEVLLRSVRAAN-KRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYVSFRD 364

Query: 424 LGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKL 483
           LGWQDWIIAP+GYAA YCDGECSFPLNAHMNATNHAIVQTLVHLM P++VPKPCCAPTKL
Sbjct: 365 LGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKL 424

Query: 484 NAISVLYFDDNSNVILKKYRNMVVRACGCH 513
           NAISVLYFDD+SNVILKKYRNMVVR+CGCH
Sbjct: 425 NAISVLYFDDSSNVILKKYRNMVVRSCGCH 454


>gi|29571106 bone morphogenetic protein 8B preproprotein [Homo
           sapiens]
          Length = 402

 Score =  380 bits (977), Expect = e-105
 Identities = 213/468 (45%), Positives = 279/468 (59%), Gaps = 86/468 (18%)

Query: 47  GGSPGRTEQPPPSPQSSSGFLYRRLKTQEKREMQKEILSVLGLPHRPRPLHGLQQPQPPA 106
           GG PG    PP  PQ       RRL  +E+R++Q+EIL+VLGLP RPRP           
Sbjct: 20  GGGPG-LRPPPGCPQ-------RRLGARERRDVQREILAVLGLPGRPRP----------- 60

Query: 107 LRQQEEQQQQQQLPRGEPPPGRLK-SAPLFMLDLYNALSADNDEDGASEGERQQSWPHEA 165
                         R  P   RL  SAPLFMLDLY+A++ D+DEDGA             
Sbjct: 61  --------------RAPPAASRLPASAPLFMLDLYHAMAGDDDEDGA------------- 93

Query: 166 ASSSQRRQPPPGAAHPLNRKSLLAPGSGSGGASPLTSAQDSAFLNDADMVMSFVNLVEYD 225
                          P  R+                       L  AD+VMSFVN+VE D
Sbjct: 94  ---------------PAERR-----------------------LGRADLVMSFVNMVERD 115

Query: 226 KEFSPRQRHHKEFKFNLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTFLISIYQVLQEHQH 285
           +    ++ H KEF+F+L+QIP GE VTAAEFRIYK   +    N+T  +S++QV+QE  +
Sbjct: 116 RALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSI-HLLNRTLHVSMFQVVQEQSN 174

Query: 286 RDSDLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTRDGVHVHPRAAG 345
           R+SDLF LD + + A +EGWL  D+TA S+ W++    ++GL+L V T DG  V P  AG
Sbjct: 175 RESDLFFLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAG 234

Query: 346 LVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNS 405
           L+G+  P  +QPF+V FF+ S   +RT R+    RR+Q +  +   Q         D + 
Sbjct: 235 LLGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVHG 294

Query: 406 SELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLV 465
           S  +  CR+HELYVSFQDLGW DW+IAP+GY+A YC+GECSFPL++ MNATNHAI+Q+LV
Sbjct: 295 SHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLV 354

Query: 466 HLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGCH 513
           HLM P+ VPK CCAPTKL+A SVLY+D ++NVIL+K+RNMVV+ACGCH
Sbjct: 355 HLMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH 402


>gi|145611428 bone morphogenetic protein 8A [Homo sapiens]
          Length = 402

 Score =  380 bits (977), Expect = e-105
 Identities = 212/468 (45%), Positives = 276/468 (58%), Gaps = 86/468 (18%)

Query: 47  GGSPGRTEQPPPSPQSSSGFLYRRLKTQEKREMQKEILSVLGLPHRPRPLHGLQQPQPPA 106
           GG PG    PP  PQ       RRL  +E+R++Q+EIL+VLGLP RPRP           
Sbjct: 20  GGGPG-LRPPPGCPQ-------RRLGARERRDVQREILAVLGLPGRPRP----------- 60

Query: 107 LRQQEEQQQQQQLPRGEPPPGRLK-SAPLFMLDLYNALSADNDEDGASEGERQQSWPHEA 165
                         R  P   RL  SAPLFMLDLY+A++ D+DEDGA   +R        
Sbjct: 61  --------------RAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPAEQR-------- 98

Query: 166 ASSSQRRQPPPGAAHPLNRKSLLAPGSGSGGASPLTSAQDSAFLNDADMVMSFVNLVEYD 225
                                                      L  AD+VMSFVN+VE D
Sbjct: 99  -------------------------------------------LGRADLVMSFVNMVERD 115

Query: 226 KEFSPRQRHHKEFKFNLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTFLISIYQVLQEHQH 285
           +    ++ H KEF+F+L+QIP GE VTAAEFRIYK   +    N+T  +S++QV+QE  +
Sbjct: 116 RALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSI-HLLNRTLHVSMFQVVQEQSN 174

Query: 286 RDSDLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTRDGVHVHPRAAG 345
           R+SDLF LD + + A +EGWL  D+TA S+ W++    ++GL+L V T DG  V P  AG
Sbjct: 175 RESDLFFLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAG 234

Query: 346 LVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNS 405
           L+G+  P  +QPF+V FF+ S   +RT R+    RR+Q +  +   Q         D   
Sbjct: 235 LLGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVRG 294

Query: 406 SELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLV 465
           S  +  CR+HELYVSFQDLGW DW+IAP+GY+A YC+GECSFPL++ MNATNHAI+Q+LV
Sbjct: 295 SHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLV 354

Query: 466 HLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGCH 513
           HLM P  VPK CCAPTKL+A SVLY+D ++NVIL+K+RNMVV+ACGCH
Sbjct: 355 HLMKPNAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH 402


>gi|4557369 bone morphogenetic protein 2 preproprotein [Homo
           sapiens]
          Length = 396

 Score =  186 bits (472), Expect = 4e-47
 Identities = 123/357 (34%), Positives = 179/357 (50%), Gaps = 40/357 (11%)

Query: 170 QRRQPPPGAAHPLNRKSLLAPGSGSGGASPLTSAQDSAFLNDADMVMSFVNLVEYDKEFS 229
           QR  P   A  P     L    SG  G SP    +     + A+ V SF +    ++   
Sbjct: 65  QRPTPSRDAVVPPYMLDLYRRHSGQPG-SPAPDHRLERAASRANTVRSFHHEESLEELPE 123

Query: 230 PRQRHHKEFKFNLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTFL---ISIYQVLQEHQHR 286
              +  + F FNLS IP  E +T+AE +++++ +  +  N +     I+IY++++     
Sbjct: 124 TSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSFHHRINIYEIIKPATAN 183

Query: 287 DSDLF--LLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVV---TRDGVHV-H 340
                  LLDTR+V  +   W  FD+T     W      N G  + V     + GV   H
Sbjct: 184 SKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQGHANHGFVVEVAHLEEKQGVSKRH 243

Query: 341 PRAAGLVGRDGPYDKQ--PFMVAFF---KVSEVHVRTTRSASSRRRQQSRNRSTQSQDVA 395
            R +  + +D     Q  P +V F    K   +H R  R A  ++R++            
Sbjct: 244 VRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPLHKREKRQAKHKQRKR------------ 291

Query: 396 RVSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNA 455
                       LK++C++H LYV F D+GW DWI+AP GY A YC GEC FPL  H+N+
Sbjct: 292 ------------LKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNS 339

Query: 456 TNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512
           TNHAIVQTLV+ +N + +PK CC PT+L+AIS+LY D+N  V+LK Y++MVV  CGC
Sbjct: 340 TNHAIVQTLVNSVNSK-IPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGC 395


>gi|157276597 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score =  185 bits (469), Expect = 1e-46
 Identities = 113/286 (39%), Positives = 152/286 (53%), Gaps = 29/286 (10%)

Query: 238 FKFNLSQIPEGEVVTAAEFRIYKDCV-MGSFKNQTF-LISIYQVLQ---EHQHRDSDLFL 292
           F FNLS IPE EV+++AE R++++ V  G    + F  I+IY+V++   E         L
Sbjct: 140 FLFNLSSIPENEVISSAELRLFREQVDQGPDWERGFHRINIYEVMKPPAEVVPGHLITRL 199

Query: 293 LDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVV------TRDGVHVHPRAAGL 346
           LDTR+V  +   W  FD++     W    Q N GL + V       T  G HV    +  
Sbjct: 200 LDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLP 259

Query: 347 VGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNSS 406
            G       +P +V F      H  T      RRR+  R+    SQ   + +        
Sbjct: 260 QGSGNWAQLRPLLVTFGHDGRGHALT------RRRRAKRSPKHHSQRARKKNKN------ 307

Query: 407 ELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVH 466
                CR+H LYV F D+GW DWI+AP GY A YC G+C FPL  H+N+TNHAIVQTLV+
Sbjct: 308 -----CRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVN 362

Query: 467 LMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512
            +N   +PK CC PT+L+AIS+LY D+   V+LK Y+ MVV  CGC
Sbjct: 363 SVNSS-IPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGC 407


>gi|157276595 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score =  185 bits (469), Expect = 1e-46
 Identities = 113/286 (39%), Positives = 152/286 (53%), Gaps = 29/286 (10%)

Query: 238 FKFNLSQIPEGEVVTAAEFRIYKDCV-MGSFKNQTF-LISIYQVLQ---EHQHRDSDLFL 292
           F FNLS IPE EV+++AE R++++ V  G    + F  I+IY+V++   E         L
Sbjct: 140 FLFNLSSIPENEVISSAELRLFREQVDQGPDWERGFHRINIYEVMKPPAEVVPGHLITRL 199

Query: 293 LDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVV------TRDGVHVHPRAAGL 346
           LDTR+V  +   W  FD++     W    Q N GL + V       T  G HV    +  
Sbjct: 200 LDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLP 259

Query: 347 VGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNSS 406
            G       +P +V F      H  T      RRR+  R+    SQ   + +        
Sbjct: 260 QGSGNWAQLRPLLVTFGHDGRGHALT------RRRRAKRSPKHHSQRARKKNKN------ 307

Query: 407 ELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVH 466
                CR+H LYV F D+GW DWI+AP GY A YC G+C FPL  H+N+TNHAIVQTLV+
Sbjct: 308 -----CRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVN 362

Query: 467 LMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512
            +N   +PK CC PT+L+AIS+LY D+   V+LK Y+ MVV  CGC
Sbjct: 363 SVNSS-IPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGC 407


>gi|157276593 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score =  185 bits (469), Expect = 1e-46
 Identities = 113/286 (39%), Positives = 152/286 (53%), Gaps = 29/286 (10%)

Query: 238 FKFNLSQIPEGEVVTAAEFRIYKDCV-MGSFKNQTF-LISIYQVLQ---EHQHRDSDLFL 292
           F FNLS IPE EV+++AE R++++ V  G    + F  I+IY+V++   E         L
Sbjct: 140 FLFNLSSIPENEVISSAELRLFREQVDQGPDWERGFHRINIYEVMKPPAEVVPGHLITRL 199

Query: 293 LDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVV------TRDGVHVHPRAAGL 346
           LDTR+V  +   W  FD++     W    Q N GL + V       T  G HV    +  
Sbjct: 200 LDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLP 259

Query: 347 VGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNSS 406
            G       +P +V F      H  T      RRR+  R+    SQ   + +        
Sbjct: 260 QGSGNWAQLRPLLVTFGHDGRGHALT------RRRRAKRSPKHHSQRARKKNKN------ 307

Query: 407 ELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVH 466
                CR+H LYV F D+GW DWI+AP GY A YC G+C FPL  H+N+TNHAIVQTLV+
Sbjct: 308 -----CRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVN 362

Query: 467 LMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512
            +N   +PK CC PT+L+AIS+LY D+   V+LK Y+ MVV  CGC
Sbjct: 363 SVNSS-IPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGC 407


>gi|10190670 growth differentiation factor 3 precursor [Homo
           sapiens]
          Length = 364

 Score =  140 bits (354), Expect = 2e-33
 Identities = 90/280 (32%), Positives = 140/280 (50%), Gaps = 34/280 (12%)

Query: 240 FNLSQIPEGEVVTAAEFRIYKDCVMGSFKN-------QTFLISIYQVLQEHQHRDSDLFL 292
           FNLS I E E +T A+  +  D    S+ N         FL+    V  +   +   +F+
Sbjct: 111 FNLSAIKEREQLTLAQLGL--DLGPNSYYNLGPELELALFLVQEPHVWGQTTPKPGKMFV 168

Query: 293 LDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTRDGVHVHPRAAGLVGRDGP 352
           L + V W   +G + F++   +  W   P+ N GL L ++ ++             RD  
Sbjct: 169 LRS-VPWP--QGAVHFNLLDVAKDWNDNPRKNFGLFLEILVKED------------RDSG 213

Query: 353 YDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNSSELKTAC 412
            + QP          +H        +  +     +   +  V ++S          K  C
Sbjct: 214 VNFQPEDTCARLRCSLHASLLVVTLNPDQCHPSRKRRAAIPVPKLSC---------KNLC 264

Query: 413 RKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEY 472
            +H+L+++F+DLGW  WIIAPKG+ ANYC GEC F L   +N++N+A +Q L+H ++PE 
Sbjct: 265 HRHQLFINFRDLGWHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHAVDPE- 323

Query: 473 VPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512
           +P+  C PTKL+ IS+LY D+N NVIL+ Y +MVV  CGC
Sbjct: 324 IPQAVCIPTKLSPISMLYQDNNDNVILRHYEDMVVDECGC 363


>gi|4503969 growth differentiation factor 5 preproprotein [Homo
           sapiens]
          Length = 501

 Score =  137 bits (344), Expect = 3e-32
 Identities = 149/546 (27%), Positives = 227/546 (41%), Gaps = 100/546 (18%)

Query: 10  WLCWWWGL--LCSCCGPPPL------------------RPPLPAAAAAAAGGQLLGDGGS 49
           W   W  L  +C+  G P L                  RPPL A      GG   G G +
Sbjct: 12  WYLAWLDLEFICTVLGAPDLGQRPQGTRPGLAKAEAKERPPL-ARNVFRPGGHSYGGGAT 70

Query: 50  PGRTEQPPPSPQSSSGFLYRRLKTQEKREMQKEILSVLGLPHRPRPLHGLQQPQPPALRQ 109
                    + Q+          TQ K++  K++    G P  P+P H      PP  RQ
Sbjct: 71  NANARAKGGTGQTGG-------LTQPKKDEPKKLPPRPGGPE-PKPGH------PPQTRQ 116

Query: 110 QEEQQ--QQQQLPRGEPPPGRLKSAPLFMLDLYNALSADNDEDGASEGERQQSWPHEAAS 167
              +    + QLP G+ PP        F+L                +  R+   P E   
Sbjct: 117 ATARTVTPKGQLPGGKAPPKAGSVPSSFLL----------------KKAREPGPPREP-- 158

Query: 168 SSQRRQPPPGAAHP--LNRKSLLAPGSGSGGASPLTSAQDSAFLNDADMVMSFVNLVEYD 225
             +  +PPP   H   L+    L+     GG S   S +  A L  A+ + SF++  + D
Sbjct: 159 -KEPFRPPPITPHEYMLSLYRTLSDADRKGGNS---SVKLEAGL--ANTITSFIDKGQDD 212

Query: 226 KEFSPRQRHHKEFKFNLSQIPEGEVVTAAEFRIYKDCVMGSFK------NQTFLISIYQV 279
           +    R++    + F++S + E + +  AE RI +     + K       +   + +   
Sbjct: 213 RGPVVRKQR---YVFDISAL-EKDGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSC 268

Query: 280 LQEHQHRDSDLFLLDTRVVWASE-EGWLEFDITA-------TSNLWVVTPQHNMGLQLSV 331
               Q       LLD R V   +  GW  FDI         ++ L +       G  + +
Sbjct: 269 PSGRQPAS----LLDVRSVPGLDGSGWEVFDIWKLFRNFKNSAQLCLELEAWERGRAVDL 324

Query: 332 ----VTRDGVHVHPRAAGLV-GRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRN 386
                 R    VH +A  LV GR    D       FF  +E+  R+ +   +        
Sbjct: 325 RGLGFDRAARQVHEKALFLVFGRTKKRD------LFF--NEIKARSGQDDKTVYEYLFSQ 376

Query: 387 RSTQSQDVARVSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECS 446
           R  +   +A  +      S  LK  C +  L+V+F+D+GW DWIIAP  Y A +C+G C 
Sbjct: 377 RRKRRAPLA--TRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCE 434

Query: 447 FPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMV 506
           FPL +H+  TNHA++QTL++ M+PE  P  CC PT+L+ IS+L+ D  +NV+ K+Y +MV
Sbjct: 435 FPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMV 494

Query: 507 VRACGC 512
           V +CGC
Sbjct: 495 VESCGC 500


>gi|48475062 growth differentiation factor 6 precursor [Homo
           sapiens]
          Length = 455

 Score =  132 bits (332), Expect = 8e-31
 Identities = 55/101 (54%), Positives = 73/101 (72%)

Query: 412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPE 471
           C K  L+V+F++LGW DWIIAP  Y A +C+G C FPL +H+  TNHAI+QTL++ M+P 
Sbjct: 354 CSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPG 413

Query: 472 YVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512
             P  CC PTKL  IS+LY D  +NV+ K+Y +MVV +CGC
Sbjct: 414 STPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGC 454



 Score = 33.1 bits (74), Expect = 0.62
 Identities = 28/119 (23%), Positives = 52/119 (43%), Gaps = 5/119 (4%)

Query: 145 ADNDEDGASEGERQQSWPHEAASSSQ-RRQPPPGAAHPLNRKSLLAPGSGSGGASPLTSA 203
           A  D D   EG+  Q  P +   + Q R Q PPG    +     +     +   +     
Sbjct: 54  APRDSDAGREGQEPQPRPQDEPRAQQPRAQEPPGRGPRVVPHEYMLSIYRTYSIAEKLGI 113

Query: 204 QDSAFLN--DADMVMSFVNLVEYDKEFSPRQRHHKEFKFNLSQIPEGEVVTAAEFRIYK 260
             S F +   A+ + SFV+    D   +P +R  +++ F++S + + E +  AE R+++
Sbjct: 114 NASFFQSSKSANTITSFVDRGLDDLSHTPLRR--QKYLFDVSMLSDKEELVGAELRLFR 170


>gi|61835232 growth differentiation factor 7 preproprotein [Homo
           sapiens]
          Length = 450

 Score =  129 bits (325), Expect = 5e-30
 Identities = 53/104 (50%), Positives = 74/104 (71%)

Query: 409 KTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLM 468
           ++ C +  L+V F++LGW DWIIAP  Y A +C+G C FPL +H+  TNHAI+QTL++ M
Sbjct: 346 RSRCSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNSM 405

Query: 469 NPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512
            P+  P  CC P +L+ IS+LY D  +NV+ K+Y +MVV ACGC
Sbjct: 406 APDAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGC 449


>gi|7705308 growth differentiation factor 2 [Homo sapiens]
          Length = 429

 Score =  129 bits (324), Expect = 6e-30
 Identities = 102/312 (32%), Positives = 133/312 (42%), Gaps = 39/312 (12%)

Query: 230 PRQRHHKEFKFNLSQIPEGEVVTAAEFRIYKDCV--MGSFKNQTFLISIYQVLQEHQHRD 287
           P Q+H     FN+S IP  E +T AE R+Y  C   +    +    + IY VL      D
Sbjct: 127 PFQKHI--LLFNIS-IPRHEQITRAELRLYVSCQNHVDPSHDLKGSVVIYDVLDGTDAWD 183

Query: 288 S----DLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTRDGVHVHPRA 343
           S      FL+   +    +EGW   ++++    WV +       +L V     V  H + 
Sbjct: 184 SATETKTFLVSQDI---QDEGWETLEVSSAVKRWVRSDSTKSKNKLEVT----VESHRKG 236

Query: 344 AGLVGRDGPYDKQ--PFMVAFFKVSEVHVRTTR--------------------SASSRRR 381
              +    P   +  PF V F        + TR                      S+   
Sbjct: 237 CDTLDISVPPGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLSKDGSTEAG 296

Query: 382 QQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYC 441
           + S    T     A  + A    S+   + C+K  L V+F+D+GW  WIIAPK Y A  C
Sbjct: 297 ESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYEC 356

Query: 442 DGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILK- 500
            G C FPL   +  T HAIVQTLVHL  P  V K CC PTKL+ ISVLY DD     LK 
Sbjct: 357 KGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKY 416

Query: 501 KYRNMVVRACGC 512
            Y  M V  CGC
Sbjct: 417 HYEGMSVAECGC 428


>gi|7656928 bone morphogenetic protein 10 preproprotein [Homo
           sapiens]
          Length = 424

 Score =  124 bits (311), Expect = 2e-28
 Identities = 87/343 (25%), Positives = 146/343 (42%), Gaps = 45/343 (13%)

Query: 203 AQDSAFLNDADMVMSFVNLVEYDKEFSPRQRHHKEFKFNLSQIPEGEVVTAAEFRIY--- 259
           A D   +  A+++ SF N   + +  S          FN+S IP  E V  AE R+Y   
Sbjct: 93  ATDRTSMPSANIIRSFKNEDLFSQPVSFNGLRKYPLLFNVS-IPHHEEVIMAELRLYTLV 151

Query: 260 -KDCVMGSFKNQTFLISIYQVLQEHQHRDSD--LFLLDTRVVWASEEGWLEFDITATSNL 316
            +D ++  +      I+I++VL+     + +  + +L +  ++ +   W  FD+T     
Sbjct: 152 QRDRMI--YDGVDRKITIFEVLESKGDNEGERNMLVLVSGEIYGTNSEWETFDVTDAIRR 209

Query: 317 WVVTPQHNMGLQLSVVTRDGVHVHPRAAGL-VGRDGPYDKQPFMVAFFKVSEVHVRTTRS 375
           W  +      L++ + ++        +  L +         P ++ F         +   
Sbjct: 210 WQKSGSSTHQLEVHIESKHDEAEDASSGRLEIDTSAQNKHNPLLIVF---------SDDQ 260

Query: 376 ASSRRRQQSRNRSTQSQDVARVSSAS--DYNSSELKTA---------------------- 411
           +S + R++  N     + +  + +     ++S   + A                      
Sbjct: 261 SSDKERKEELNEMISHEQLPELDNLGLDSFSSGPGEEALLQMRSNIIYDSTARIRRNAKG 320

Query: 412 --CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMN 469
             C++  LY+ F+++GW  WIIAP GY A  C G C++PL  H+  T HAI+Q LVHL N
Sbjct: 321 NYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKN 380

Query: 470 PEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512
            +   K CC PTKL  IS+LY D        KY  M V  CGC
Sbjct: 381 SQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGC 423


>gi|126507087 bone morphogenetic protein 3 preproprotein [Homo
           sapiens]
          Length = 472

 Score =  120 bits (300), Expect = 4e-27
 Identities = 53/150 (35%), Positives = 87/150 (58%), Gaps = 11/150 (7%)

Query: 374 RSASSRRRQQSRNRSTQSQDVARVSSASDYNSSELKTA----------CRKHELYVSFQD 423
           ++  ++  ++S+N+  Q +   R S    ++   LK A          C +  L V F D
Sbjct: 322 KTLQAQAPEKSKNKKKQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFAD 381

Query: 424 LGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMN-PEYVPKPCCAPTK 482
           +GW +WII+PK + A YC G C FP+   +  +NHA +Q++V  +     +P+PCC P K
Sbjct: 382 IGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEK 441

Query: 483 LNAISVLYFDDNSNVILKKYRNMVVRACGC 512
           ++++S+L+FD+N NV+LK Y NM V +C C
Sbjct: 442 MSSLSILFFDENKNVVLKVYPNMTVESCAC 471


>gi|110349792 growth differentiation factor 1 [Homo sapiens]
          Length = 372

 Score =  120 bits (300), Expect = 4e-27
 Identities = 50/106 (47%), Positives = 73/106 (68%), Gaps = 4/106 (3%)

Query: 411 ACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPL----NAHMNATNHAIVQTLVH 466
           ACR   LYVSF+++GW  W+IAP+G+ ANYC G+C+ P+    +    A NHA+++ L+H
Sbjct: 266 ACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMH 325

Query: 467 LMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512
              P     PCC P +L+ ISVL+FD++ NV+L++Y +MVV  CGC
Sbjct: 326 AAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGC 371


>gi|4826740 growth differentiation factor 10 precursor [Homo
           sapiens]
          Length = 478

 Score =  108 bits (269), Expect = 2e-23
 Identities = 52/144 (36%), Positives = 81/144 (56%), Gaps = 12/144 (8%)

Query: 381 RQQSRNRSTQSQDVARVSS-ASDYNSSELKTA----------CRKHELYVSFQDLGWQDW 429
           R   ++R  + Q+V   +S   D++   ++ A          C +  L V F D+GW +W
Sbjct: 334 RPGRKDRRKKGQEVFMAASQVLDFDEKTMQKARRKQWDEPRVCSRRYLKVDFADIGWNEW 393

Query: 430 IIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMN-PEYVPKPCCAPTKLNAISV 488
           II+PK + A YC G C FP+   +  +NHA +Q++V  +     +P+PCC P K+N++ V
Sbjct: 394 IISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIIPGIPEPCCVPDKMNSLGV 453

Query: 489 LYFDDNSNVILKKYRNMVVRACGC 512
           L+ D+N NV+LK Y NM V  C C
Sbjct: 454 LFLDENRNVVLKVYPNMSVDTCAC 477


>gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]
          Length = 392

 Score =  106 bits (264), Expect = 6e-23
 Identities = 54/161 (33%), Positives = 83/161 (51%), Gaps = 6/161 (3%)

Query: 358 FMVAFFKVSEVHVRTT----RSASSRRRQQSRNRSTQSQD--VARVSSASDYNSSELKTA 411
           F++ +F  +   +R      R       ++S  R T+  D   A V+++S  +S      
Sbjct: 231 FLLLYFNDTHKSIRKAKFLPRGMEEFMERESLLRRTRQADGISAEVTASSSKHSGPENNQ 290

Query: 412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPE 471
           C  H   +SF+ LGW  WIIAP  Y  NYC G C   L   +N+ NHAI+Q L++ +  +
Sbjct: 291 CSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVDQ 350

Query: 472 YVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512
            VP+P C P K   ISVL  + N +++ K+Y  M+  +C C
Sbjct: 351 SVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTC 391


>gi|4504699 inhibin beta A precursor [Homo sapiens]
          Length = 426

 Score =  103 bits (256), Expect = 5e-22
 Identities = 49/109 (44%), Positives = 64/109 (58%), Gaps = 12/109 (11%)

Query: 412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGEC--------SFPLNAHMNATNHAIVQT 463
           C K + +VSF+D+GW DWIIAP GY ANYC+GEC           L+ H    NH  ++ 
Sbjct: 321 CCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRG 380

Query: 464 LVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512
                +P    K CC PTKL  +S+LY+DD  N+I K  +NM+V  CGC
Sbjct: 381 ----HSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGC 425


>gi|4507465 transforming growth factor, beta 3 [Homo sapiens]
          Length = 412

 Score =  102 bits (253), Expect = 1e-21
 Identities = 78/296 (26%), Positives = 131/296 (44%), Gaps = 21/296 (7%)

Query: 230 PRQRHHKEFKFNLSQIPEGEV-VTAAEFRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDS 288
           P+    K F+FN+S + +    +  AEFR+ +     S +N+   I ++Q+L+  +H   
Sbjct: 124 PKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQ-RIELFQILRPDEHIAK 182

Query: 289 DLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTR-----------DGV 337
             ++    +       WL FD+T T   W++  + N+GL++S+              + +
Sbjct: 183 QRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILENI 242

Query: 338 HVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARV 397
           H         G D   D     +   K  + H             +  N     Q   R 
Sbjct: 243 H-EVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRA 301

Query: 398 SSASDYNSSELKTACRKHELYVSF-QDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNAT 456
              ++Y    L+  C    LY+ F QDLGW+ W+  PKGY AN+C G C +  +A    T
Sbjct: 302 LD-TNYCFRNLEENCCVRPLYIDFRQDLGWK-WVHEPKGYYANFCSGPCPYLRSAD---T 356

Query: 457 NHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512
            H+ V  L + +NPE    PCC P  L  +++LY+   +  + ++  NMVV++C C
Sbjct: 357 THSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKC 411


>gi|4885259 myostatin [Homo sapiens]
          Length = 375

 Score =  100 bits (250), Expect = 2e-21
 Identities = 66/208 (31%), Positives = 90/208 (43%), Gaps = 36/208 (17%)

Query: 305 WLEFDITATSNLWVVTPQHNMGLQLSVVTRDGVHVHPRAAGLVGRDGPYDKQPFMVAFFK 364
           W   D+      W+  P+ N+G+++  +  +G  +     G  G DG     PF+     
Sbjct: 203 WQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPG-PGEDG---LNPFL----- 253

Query: 365 VSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVSFQDL 424
             EV V  T   S R                      D +    ++ C ++ L V F+  
Sbjct: 254 --EVKVTDTPKRSRR------------------DFGLDCDEHSTESRCCRYPLTVDFEAF 293

Query: 425 GWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLN 484
           GW DWIIAPK Y ANYC GEC F        T+      LVH  NP     PCC PTK++
Sbjct: 294 GW-DWIIAPKRYKANYCSGECEFVFLQKYPHTH------LVHQANPRGSAGPCCTPTKMS 346

Query: 485 AISVLYFDDNSNVILKKYRNMVVRACGC 512
            I++LYF+    +I  K   MVV  CGC
Sbjct: 347 PINMLYFNGKEQIIYGKIPAMVVDRCGC 374


>gi|222352098 nodal precursor [Homo sapiens]
          Length = 347

 Score =  100 bits (249), Expect = 3e-21
 Identities = 45/101 (44%), Positives = 60/101 (59%), Gaps = 1/101 (0%)

Query: 412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPE 471
           CRK +  V F  +GW  WII PK Y A  C+GEC  P+    + TNHA +Q+L+    P 
Sbjct: 247 CRKVKFQVDFNLIGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPH 306

Query: 472 YVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512
            VP  CCAP K   +S+LY  DN  V+L  +++M+V  CGC
Sbjct: 307 RVPSTCCAPVKTKPLSMLYV-DNGRVLLDHHKDMIVEECGC 346


>gi|5031613 growth differentiation factor 11 precursor [Homo
           sapiens]
          Length = 407

 Score = 96.7 bits (239), Expect = 5e-20
 Identities = 64/208 (30%), Positives = 88/208 (42%), Gaps = 36/208 (17%)

Query: 305 WLEFDITATSNLWVVTPQHNMGLQLSVVTRDGVHVHPRAAGLVGRDGPYDKQPFMVAFFK 364
           W   D     + W   PQ N G++++     G  +   + G     G     PFM     
Sbjct: 235 WQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLG----PGAEGLHPFM----- 285

Query: 365 VSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVSFQDL 424
                +R   +    RR    +               D +SSE +  C ++ L V F+  
Sbjct: 286 ----ELRVLENTKRSRRNLGLD--------------CDEHSSESR--CCRYPLTVDFEAF 325

Query: 425 GWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLN 484
           GW DWIIAPK Y ANYC G+C +        T+      LV   NP     PCC PTK++
Sbjct: 326 GW-DWIIAPKRYKANYCSGQCEYMFMQKYPHTH------LVQQANPRGSAGPCCTPTKMS 378

Query: 485 AISVLYFDDNSNVILKKYRNMVVRACGC 512
            I++LYF+D   +I  K   MVV  CGC
Sbjct: 379 PINMLYFNDKQQIIYGKIPGMVVDRCGC 406


>gi|13899338 activin beta E [Homo sapiens]
          Length = 350

 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 44/103 (42%), Positives = 61/103 (59%), Gaps = 2/103 (1%)

Query: 412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPL--NAHMNATNHAIVQTLVHLMN 469
           C + + YV FQ+LGW+DWI+ P+GY  NYC G+C   L  +  + A+ H+ V +L+   N
Sbjct: 247 CCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFSLLKANN 306

Query: 470 PEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512
           P      CC PT    +S+LY D N NV+     +MVV ACGC
Sbjct: 307 PWPASTSCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGC 349


>gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo
           sapiens]
          Length = 442

 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 69/270 (25%), Positives = 118/270 (43%), Gaps = 53/270 (19%)

Query: 274 ISIYQVLQEHQHRDSDLFLLDTRVVWASEEG-WLEFDITATSNLWVVTPQHNMGLQLS-- 330
           I +YQ+L+           +D++VV    EG WL FD+T   + W+     N+G ++S  
Sbjct: 194 IELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLH 253

Query: 331 ------------VVTRDGVHVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASS 378
                       ++      +  R AG+ G             +    +  +++TR  +S
Sbjct: 254 CPCCTFVPSNNYIIPNKSEELEARFAGIDGTS----------TYTSGDQKTIKSTRKKNS 303

Query: 379 RRR---------------QQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVSFQ- 422
            +                QQ+  R  ++ D A       Y    ++  C    LY+ F+ 
Sbjct: 304 GKTPHLLLMLLPSYRLESQQTNRRKKRALDAA-------YCFRNVQDNCCLRPLYIDFKR 356

Query: 423 DLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTK 482
           DLGW+ WI  PKGY AN+C G C +  ++    T H+ V +L + +NPE    PCC    
Sbjct: 357 DLGWK-WIHEPKGYNANFCAGACPYLWSSD---TQHSRVLSLYNTINPEASASPCCVSQD 412

Query: 483 LNAISVLYFDDNSNVILKKYRNMVVRACGC 512
           L  +++LY+   +  I ++  NM+V++C C
Sbjct: 413 LEPLTILYYIGKTPKI-EQLSNMIVKSCKC 441


>gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo
           sapiens]
          Length = 414

 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 69/270 (25%), Positives = 118/270 (43%), Gaps = 53/270 (19%)

Query: 274 ISIYQVLQEHQHRDSDLFLLDTRVVWASEEG-WLEFDITATSNLWVVTPQHNMGLQLS-- 330
           I +YQ+L+           +D++VV    EG WL FD+T   + W+     N+G ++S  
Sbjct: 166 IELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLH 225

Query: 331 ------------VVTRDGVHVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASS 378
                       ++      +  R AG+ G             +    +  +++TR  +S
Sbjct: 226 CPCCTFVPSNNYIIPNKSEELEARFAGIDGTS----------TYTSGDQKTIKSTRKKNS 275

Query: 379 RRR---------------QQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVSFQ- 422
            +                QQ+  R  ++ D A       Y    ++  C    LY+ F+ 
Sbjct: 276 GKTPHLLLMLLPSYRLESQQTNRRKKRALDAA-------YCFRNVQDNCCLRPLYIDFKR 328

Query: 423 DLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTK 482
           DLGW+ WI  PKGY AN+C G C +  ++    T H+ V +L + +NPE    PCC    
Sbjct: 329 DLGWK-WIHEPKGYNANFCAGACPYLWSSD---TQHSRVLSLYNTINPEASASPCCVSQD 384

Query: 483 LNAISVLYFDDNSNVILKKYRNMVVRACGC 512
           L  +++LY+   +  I ++  NM+V++C C
Sbjct: 385 LEPLTILYYIGKTPKI-EQLSNMIVKSCKC 413


>gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]
          Length = 407

 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 43/105 (40%), Positives = 61/105 (58%), Gaps = 5/105 (4%)

Query: 412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATN--HAIV--QTLVHL 467
           C + + ++ F+ +GW DWIIAP GY  NYC+G C   L     + +  H  V  Q  +  
Sbjct: 303 CCRQQFFIDFRLIGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMRG 362

Query: 468 MNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512
           +NP  V   CC PTKL+ +S+LYFDD  N++ +   NM+V  CGC
Sbjct: 363 LNPGTV-NSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGC 406


>gi|4885261 growth differentiation factor 9 precursor [Homo sapiens]
          Length = 454

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 44/157 (28%), Positives = 74/157 (47%), Gaps = 10/157 (6%)

Query: 363 FKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNSSEL-------KTACRKH 415
           + V E      RS+  R R   R + T S ++ +    + +N SE        +  C  H
Sbjct: 300 YPVGEEAAEDGRSSHHRHR---RGQETVSSELKKPLGPASFNLSEYFRQFLLPQNECELH 356

Query: 416 ELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPK 475
           +  +SF  L W +WI+AP  Y   YC G+C   +     +  H +VQ +++      VP+
Sbjct: 357 DFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDSSVPR 416

Query: 476 PCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512
           P C P K + +SVL  + + ++  K+Y +M+   C C
Sbjct: 417 PSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453


>gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]
          Length = 352

 Score = 82.4 bits (202), Expect = 9e-16
 Identities = 39/105 (37%), Positives = 58/105 (55%), Gaps = 4/105 (3%)

Query: 412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNA--HMNATNHAIVQTLVHLMN 469
           C + E +V F+++GW DWII P+GYA N+C G+C   +     + A+ H  V  L+    
Sbjct: 247 CCRQEFFVDFREIGWHDWIIQPEGYAMNFCIGQCPLHIAGMPGIAASFHTAVLNLLKANT 306

Query: 470 PEYVP--KPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512
                    CC PT    +S+LY+D +SN++     +MVV ACGC
Sbjct: 307 AAGTTGGGSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEACGC 351


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.133    0.415 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,664,138
Number of Sequences: 37866
Number of extensions: 1323635
Number of successful extensions: 12299
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 126
Number of HSP's successfully gapped in prelim test: 383
Number of HSP's that attempted gapping in prelim test: 9731
Number of HSP's gapped (non-prelim): 1981
length of query: 513
length of database: 18,247,518
effective HSP length: 107
effective length of query: 406
effective length of database: 14,195,856
effective search space: 5763517536
effective search space used: 5763517536
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.