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Search of human proteins with 44955929
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|44955929 calmodulin regulated spectrin-associated protein
1-like 1 [Homo sapiens]
(1478 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|44955929 calmodulin regulated spectrin-associated protein 1-l... 2957 0.0
gi|130502140 NEZHA isoform 2 [Homo sapiens] 662 0.0
gi|122937255 NEZHA isoform 1 [Homo sapiens] 651 0.0
gi|186659512 calmodulin regulated spectrin-associated protein 1 ... 561 e-159
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 70 2e-11
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens] 59 5e-08
gi|171184451 centrosome-associated protein 350 [Homo sapiens] 56 2e-07
gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens] 55 4e-07
gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens] 55 4e-07
gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens] 55 4e-07
gi|110349719 titin isoform N2-A [Homo sapiens] 54 1e-06
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 53 2e-06
gi|4505101 microtubule-associated protein 7 [Homo sapiens] 53 2e-06
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 52 3e-06
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 52 3e-06
gi|51873049 hypothetical protein LOC8603 [Homo sapiens] 52 3e-06
gi|15826852 acyl-Coenzyme A binding domain containing 3 [Homo sa... 52 3e-06
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 52 4e-06
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 52 4e-06
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 52 4e-06
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 52 4e-06
gi|148746195 trichohyalin [Homo sapiens] 52 4e-06
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 52 6e-06
gi|19718731 bromodomain-containing protein 4 isoform long [Homo ... 51 7e-06
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 51 7e-06
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 51 7e-06
gi|150170670 piccolo isoform 2 [Homo sapiens] 50 2e-05
gi|150378539 piccolo isoform 1 [Homo sapiens] 50 2e-05
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 49 5e-05
gi|171460958 nucleolar protein 10 [Homo sapiens] 49 5e-05
>gi|44955929 calmodulin regulated spectrin-associated protein 1-like 1
[Homo sapiens]
Length = 1478
Score = 2957 bits (7667), Expect = 0.0
Identities = 1478/1478 (100%), Positives = 1478/1478 (100%)
Query: 1 MGDAADPREMRKTFIVPAIKPFDHYDFSRAKIACNLAWLVAKAFGTENVPEELQEPFYTD 60
MGDAADPREMRKTFIVPAIKPFDHYDFSRAKIACNLAWLVAKAFGTENVPEELQEPFYTD
Sbjct: 1 MGDAADPREMRKTFIVPAIKPFDHYDFSRAKIACNLAWLVAKAFGTENVPEELQEPFYTD 60
Query: 61 QYDQEHIKPPVVNLLLSAELYCRAGSLILKSDAAKPLLGHDAVIQALAQKGLYVTDQEKL 120
QYDQEHIKPPVVNLLLSAELYCRAGSLILKSDAAKPLLGHDAVIQALAQKGLYVTDQEKL
Sbjct: 61 QYDQEHIKPPVVNLLLSAELYCRAGSLILKSDAAKPLLGHDAVIQALAQKGLYVTDQEKL 120
Query: 121 VTERDLHKKPIQMSAHLAMIDTLMMAYTVEMVSIEKVIACAQQYSAFFQATDLPYDIEDA 180
VTERDLHKKPIQMSAHLAMIDTLMMAYTVEMVSIEKVIACAQQYSAFFQATDLPYDIEDA
Sbjct: 121 VTERDLHKKPIQMSAHLAMIDTLMMAYTVEMVSIEKVIACAQQYSAFFQATDLPYDIEDA 180
Query: 181 VMYWINKVNEHLKDIMEQEQKLKEHHTVEAPGGQKARYRKEQTLLKQLPCIPLVENLLKD 240
VMYWINKVNEHLKDIMEQEQKLKEHHTVEAPGGQKARYRKEQTLLKQLPCIPLVENLLKD
Sbjct: 181 VMYWINKVNEHLKDIMEQEQKLKEHHTVEAPGGQKARYRKEQTLLKQLPCIPLVENLLKD 240
Query: 241 GTDGCALAALIHFYCPDVVRLEDICLKETMSLADSLYNLQLIQEFCQEYLNQCCHFTLED 300
GTDGCALAALIHFYCPDVVRLEDICLKETMSLADSLYNLQLIQEFCQEYLNQCCHFTLED
Sbjct: 241 GTDGCALAALIHFYCPDVVRLEDICLKETMSLADSLYNLQLIQEFCQEYLNQCCHFTLED 300
Query: 301 MLYAASSIKSNYLVFMAELFWWFEVVKPSFVQPRVVRPQGAEPVKDMPSIPVLNAAKRNV 360
MLYAASSIKSNYLVFMAELFWWFEVVKPSFVQPRVVRPQGAEPVKDMPSIPVLNAAKRNV
Sbjct: 301 MLYAASSIKSNYLVFMAELFWWFEVVKPSFVQPRVVRPQGAEPVKDMPSIPVLNAAKRNV 360
Query: 361 LDSSSDFPSSGEGATFTQSHHHLPSRYSRPQAHSSASGGIRRSSSMSYVDGFIGTWPKEK 420
LDSSSDFPSSGEGATFTQSHHHLPSRYSRPQAHSSASGGIRRSSSMSYVDGFIGTWPKEK
Sbjct: 361 LDSSSDFPSSGEGATFTQSHHHLPSRYSRPQAHSSASGGIRRSSSMSYVDGFIGTWPKEK 420
Query: 421 RSSVHGVSFDISFDKEDSVQRSTPNRGITRSISNEGLTLNNSHVSKHIRKNLSFKPINGE 480
RSSVHGVSFDISFDKEDSVQRSTPNRGITRSISNEGLTLNNSHVSKHIRKNLSFKPINGE
Sbjct: 421 RSSVHGVSFDISFDKEDSVQRSTPNRGITRSISNEGLTLNNSHVSKHIRKNLSFKPINGE 480
Query: 481 EEAESIEEELNIDSHSDLKSCVPLNTNELNSNENIHYKLPNGALQNRILLDEFGNQIETP 540
EEAESIEEELNIDSHSDLKSCVPLNTNELNSNENIHYKLPNGALQNRILLDEFGNQIETP
Sbjct: 481 EEAESIEEELNIDSHSDLKSCVPLNTNELNSNENIHYKLPNGALQNRILLDEFGNQIETP 540
Query: 541 SIEEALQIIHDTEKSPHTPQPDQIANGFFLHSQEMSILNSNIKLNQSSPDNVTDTKGALS 600
SIEEALQIIHDTEKSPHTPQPDQIANGFFLHSQEMSILNSNIKLNQSSPDNVTDTKGALS
Sbjct: 541 SIEEALQIIHDTEKSPHTPQPDQIANGFFLHSQEMSILNSNIKLNQSSPDNVTDTKGALS 600
Query: 601 PITDNTEVDTGIHVPSEDIPETMDEDSSLRDYTVSLDSDMDDASKFLQDYDIRTGNTREA 660
PITDNTEVDTGIHVPSEDIPETMDEDSSLRDYTVSLDSDMDDASKFLQDYDIRTGNTREA
Sbjct: 601 PITDNTEVDTGIHVPSEDIPETMDEDSSLRDYTVSLDSDMDDASKFLQDYDIRTGNTREA 660
Query: 661 LSPCPSTVSTKSQPGSSASSSSGVKMTSFAEQKFRKLNHTDGKSSGSSSQKTTPEGSELN 720
LSPCPSTVSTKSQPGSSASSSSGVKMTSFAEQKFRKLNHTDGKSSGSSSQKTTPEGSELN
Sbjct: 661 LSPCPSTVSTKSQPGSSASSSSGVKMTSFAEQKFRKLNHTDGKSSGSSSQKTTPEGSELN 720
Query: 721 IPHVVAWAQIPEETGLPQGRDTTQLLASEMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQ 780
IPHVVAWAQIPEETGLPQGRDTTQLLASEMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQ
Sbjct: 721 IPHVVAWAQIPEETGLPQGRDTTQLLASEMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQ 780
Query: 781 KMGRTAFLTVVKKKGDGISPLREEAAGAEDEKVYTDRAKEKESQKTDGQRSKSLADIKES 840
KMGRTAFLTVVKKKGDGISPLREEAAGAEDEKVYTDRAKEKESQKTDGQRSKSLADIKES
Sbjct: 781 KMGRTAFLTVVKKKGDGISPLREEAAGAEDEKVYTDRAKEKESQKTDGQRSKSLADIKES 840
Query: 841 MENPQAKWLKSPTTPIDPEKQWNLASPSEETLNEGEILEYTKSIEKLNSSLHFLQQEMQR 900
MENPQAKWLKSPTTPIDPEKQWNLASPSEETLNEGEILEYTKSIEKLNSSLHFLQQEMQR
Sbjct: 841 MENPQAKWLKSPTTPIDPEKQWNLASPSEETLNEGEILEYTKSIEKLNSSLHFLQQEMQR 900
Query: 901 LSLQQEMLMQMREQQSWVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSP 960
LSLQQEMLMQMREQQSWVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSP
Sbjct: 901 LSLQQEMLMQMREQQSWVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSP 960
Query: 961 QSSNRKSASFSVKSQRTPRPNELKITPLNRTLTPPRSVDSLPRLRRFSPSQVPIQTRSFV 1020
QSSNRKSASFSVKSQRTPRPNELKITPLNRTLTPPRSVDSLPRLRRFSPSQVPIQTRSFV
Sbjct: 961 QSSNRKSASFSVKSQRTPRPNELKITPLNRTLTPPRSVDSLPRLRRFSPSQVPIQTRSFV 1020
Query: 1021 CFGDDGEPQLKESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPVTET 1080
CFGDDGEPQLKESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPVTET
Sbjct: 1021 CFGDDGEPQLKESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPVTET 1080
Query: 1081 VCLTPNEDQLNQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGESDKE 1140
VCLTPNEDQLNQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGESDKE
Sbjct: 1081 VCLTPNEDQLNQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGESDKE 1140
Query: 1141 QFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEET 1200
QFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEET
Sbjct: 1141 QFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEET 1200
Query: 1201 RRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHR 1260
RRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHR
Sbjct: 1201 RRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHR 1260
Query: 1261 DHIESPKTPIKGPPVSSLSLASLNTGDNESVHSGKRTPRSESVEGFLSPSRCGSRNGEKD 1320
DHIESPKTPIKGPPVSSLSLASLNTGDNESVHSGKRTPRSESVEGFLSPSRCGSRNGEKD
Sbjct: 1261 DHIESPKTPIKGPPVSSLSLASLNTGDNESVHSGKRTPRSESVEGFLSPSRCGSRNGEKD 1320
Query: 1321 WENASTTSSVASGTEYTGPKLYKEPSAKSNKHIIQNALAHCCLAGKVNEGQKKKILEEME 1380
WENASTTSSVASGTEYTGPKLYKEPSAKSNKHIIQNALAHCCLAGKVNEGQKKKILEEME
Sbjct: 1321 WENASTTSSVASGTEYTGPKLYKEPSAKSNKHIIQNALAHCCLAGKVNEGQKKKILEEME 1380
Query: 1381 KSDANNFLILFRDSGCQFRSLYTYCPETEEINKLTGIGPKSITKKMIEGLYKYNSDRKQF 1440
KSDANNFLILFRDSGCQFRSLYTYCPETEEINKLTGIGPKSITKKMIEGLYKYNSDRKQF
Sbjct: 1381 KSDANNFLILFRDSGCQFRSLYTYCPETEEINKLTGIGPKSITKKMIEGLYKYNSDRKQF 1440
Query: 1441 SHIPAKTLSASVDAITIHSHLWQTKRPVTPKKLLPTKA 1478
SHIPAKTLSASVDAITIHSHLWQTKRPVTPKKLLPTKA
Sbjct: 1441 SHIPAKTLSASVDAITIHSHLWQTKRPVTPKKLLPTKA 1478
>gi|130502140 NEZHA isoform 2 [Homo sapiens]
Length = 1249
Score = 662 bits (1707), Expect = 0.0
Identities = 521/1517 (34%), Positives = 732/1517 (48%), Gaps = 333/1517 (21%)
Query: 7 PREMRKTFIVPAIKPFDHYDFSRAKIACNLAWLVAKAFG-TENVPEELQEPFYTDQYDQE 65
P +R+TF+VP IK D YDFSRAK A +LAW++ AFG E+VP EL EPFYTDQY QE
Sbjct: 9 PGPLRRTFLVPEIKSLDQYDFSRAKAAASLAWVLRAAFGGAEHVPPELWEPFYTDQYAQE 68
Query: 66 HIKPPVVNLLLSAELYCRAGSLILKSDAAKPLLGHDAVIQALAQKGLYVTDQEKLVTERD 125
H+KPPV LLLSAELYCRA L P A++ LA++G E+ V E D
Sbjct: 69 HVKPPVTRLLLSAELYCRAWRQALPQLETPP--NPSALLALLARRGTVPALPERPVREAD 126
Query: 126 LHKKPIQMSAHLAMIDTLMMAYTVEMV-SIEKVIACAQQYSAFFQATDLPYDIEDAVMYW 184
L +PI M AHLA+ID LM A+ E ++ +A +E +++W
Sbjct: 127 LRHQPILMGAHLAVIDALMAAFAFEWTKTLPGPLALTS--------------LEHKLLFW 172
Query: 185 INKVNEHLKDIMEQEQKLKEHHTVEAPGGQKA----RYRKEQTLLKQLPCIPLVENLLKD 240
++ L++ EQE + A G A RYRK++ + ++ PC P V +L +D
Sbjct: 173 VDTTVRRLQEKTEQEAAQRASPAAPADGAAPAQPSIRYRKDRVVARRAPCFPTVTSL-QD 231
Query: 241 GTDGCALAALIHFYCPDVVRLEDICLKETMSLADSLYNLQLIQEFCQEYLNQCCHFTLED 300
G ALAA IH YCP ++RLE++CLK+ MS+ADSLYNLQL+Q+FC L + C +LED
Sbjct: 232 LASGAALAATIHCYCPQLLRLEEVCLKDPMSVADSLYNLQLVQDFCASRLPRGCPLSLED 291
Query: 301 MLYAASSIKSNYLVFMAELFWWFEVVKPSFVQPRVVRPQGAEPVKDMPSIPVLNAAKRNV 360
+LY +K N +V +AELF FEV+KP FVQ VKD+P +AA
Sbjct: 292 LLYVPPPLKVNLVVMLAELFMCFEVLKPDFVQ-----------VKDLPDG---HAASPRG 337
Query: 361 LDSSSDFPSSGEGATFTQSHHHLPSRYSRPQAHSSASGGIRRSSSMSYVDGFIGTWPKEK 420
++S +SG + H L S SGG +
Sbjct: 338 TEASPPQNNSGSSSPVFTFRHPLLS-----------SGGPQ------------------- 367
Query: 421 RSSVHGVSFDISFDKEDSVQRSTPNRGITRSISNEGLTLNNSHVSKHIRKNLSFKPINGE 480
+P RG T S+ + + + K + LS +P++
Sbjct: 368 ----------------------SPLRGSTGSLKSSPSMSHMEALGKAWNRQLS-RPLS-- 402
Query: 481 EEAESIEEELNIDSHSDLKSCVPLNTNELNSNENIHYKLPNGALQNRILLDEFGNQIETP 540
+A S +DS D+ P+ ++S +++ P A E G + P
Sbjct: 403 -QAVSFSTPFGLDSDVDVVMGDPVLLRSVSS-DSLGPPRPAPARTPTQPPPEPG---DLP 457
Query: 541 SIEEALQIIHDTEKSPHTPQPDQIANG-FFLHSQEMSILNSNIKLNQSSPDNVTD--TKG 597
+IEEALQIIH E PD A+G F+LHS E S P + +G
Sbjct: 458 TIEEALQIIHSAEPRL---LPDGAADGSFYLHSPE----------GPSKPSLASPYLPEG 504
Query: 598 ALSPITDNTEVDTGIHVPSEDIPETMDEDSSLRDYTVSLDSDMDDASKFLQDYDIRTGNT 657
P++D +++P PET + S + +ASK
Sbjct: 505 TSKPLSDRP-TKAPVYMPH---PETPSKPSPCL---------VGEASK------------ 539
Query: 658 REALSPCPSTVSTKSQPGSSASSSSGVKMTSFAEQKFRKLNHTDGKSSGSSSQKTTPEGS 717
P PS S K+ S A+++S VKMTSFAE+K ++L + ++ G+ S +TP
Sbjct: 540 ----PPAPSEGSPKAVASSPAATNSEVKMTSFAERK-KQLVKAEAEA-GAGSPTSTPAPP 593
Query: 718 ELNIPHVVAWAQIPEETGLPQGRDTTQLLASEMVHLRMKLEEKRRAIEAQKKKMEAAFTK 777
E L+SEM L +LEEKRRAIEAQK+++EA F K
Sbjct: 594 EA--------------------------LSSEMSELSARLEEKRRAIEAQKRRIEAIFAK 627
Query: 778 QRQKMGRTAFLTVVKKKGDGISPLREEAAGAEDEKVYTDRAKEKESQKTDGQRSKSLADI 837
RQ++G++AFL V ++ G A AE E+ + E +GQ
Sbjct: 628 HRQRLGKSAFLQVQPREASG-------EAEAEAEEADSGPVPGGERPAGEGQG------- 673
Query: 838 KESMENPQAKWLKSPTTPIDPEKQWNLASPSEETLNEGEILEYTKSIEKLNSSLHFLQQE 897
E P+A P+ E + EY +++ KL+++L LQ++
Sbjct: 674 -EPTSRPKAVTFSPDLGPVPHEG----------------LGEYNRAVSKLSAALSSLQRD 716
Query: 898 MQRLSLQQEMLMQMREQQSWVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTH 957
MQRL+ QQ+ L+ +PP+ P ++ + P + P+
Sbjct: 717 MQRLTDQQQRLL----------APPEA----------PGSAPPPAAWVIPGPTTGPKAAS 756
Query: 958 PSPQSSNRKSASFSVKSQRTPRPNELKITPLNRTLTPPRSVDSLPRLRRFSPSQVPIQTR 1017
PSP + R A+ +R+P P + +P + T P + P R +P
Sbjct: 757 PSP--ARRVPAT-----RRSPGPGPSQ-SPRSPKHTRPAELRLAPLTRVLTPPH------ 802
Query: 1018 SFVCFGDDGEPQLKESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPV 1077
D P L++ P + P ++ S +L+
Sbjct: 803 -----DVDSLPHLRKFSPSQV-------------------------PVQTRSSILLA--- 829
Query: 1078 TETVCLTPNEDQLNQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADV----PVEKY 1133
+ P EP +P LIE+ L L P D P
Sbjct: 830 -----------EETPPEEPAARP----------GLIEIPLGSLADPAAEDEGDGSPAGAE 868
Query: 1134 DGESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEM 1193
D ++ + + +V GFF+KD+ K E++MA KRA+LLE++ RR +E + RKQ E E
Sbjct: 869 DSLEEEASSEGEPRVGLGFFYKDEDKPEDEMAQKRASLLERQQRRAEEARRRKQWQEVEK 928
Query: 1194 EHKKEETRRKTEEE--------------------RQKKEDERARR--EFIRQEYMRRKQL 1231
E ++EE R +EE R E+E R +F RQEY RR QL
Sbjct: 929 EQRREEAARLAQEEAPGPAPLVSAVPMATPAPAARAPAEEEVGPRKGDFTRQEYERRAQL 988
Query: 1232 KLMEDMDTVIKPR------PQVVKQKKQRPKSIHRDHIESPKTPIKG------PPVSSLS 1279
KLM+D+D V++PR P ++ RP+S D ++P +G + S S
Sbjct: 989 KLMDDLDKVLRPRAAGSGGPGRGGRRATRPRSGCCDDSALARSPARGLLGSRLSKIYSQS 1048
Query: 1280 LASLNTGDNESVHS---GKRTPRSESVEGFLSPSRC-GSRNGEKDWENASTTSSVASGTE 1335
SL+T NE+ ++ + T R+ S G +SPSR GSR E+DWEN S SS AS E
Sbjct: 1049 TLSLSTVANEAHNNLGVKRPTSRAPSPSGLMSPSRLPGSR--ERDWENGSNASSPASVPE 1106
Query: 1336 YTGPKLYKEPSAKSNKHIIQNALAHCCLAGKVNEGQKKKILEEMEKSDANNFLILFRDSG 1395
YTGP+LYKEPSAKSNK II NAL+HCCLAGKVNE QK +ILEE+EKS AN+FLILFRDS
Sbjct: 1107 YTGPRLYKEPSAKSNKFIIHNALSHCCLAGKVNEPQKNRILEEIEKSKANHFLILFRDSS 1166
Query: 1396 CQFRSLYTYCPETEEINKLTGIGPKSITKKMIEGLYKYNSDRKQFSHIPAKTLSASVDAI 1455
CQFR+LYT ETEE+++L G GP+++T M+EG+YKYNSDRK+F+ IPAKT+S SVDA
Sbjct: 1167 CQFRALYTLSGETEELSRLAGYGPRTVTPAMVEGIYKYNSDRKRFTQIPAKTMSMSVDAF 1226
Query: 1456 TIHSHLWQTKRPVTPKK 1472
TI HLWQ K+P TPKK
Sbjct: 1227 TIQGHLWQGKKPTTPKK 1243
>gi|122937255 NEZHA isoform 1 [Homo sapiens]
Length = 1276
Score = 651 bits (1680), Expect = 0.0
Identities = 521/1544 (33%), Positives = 732/1544 (47%), Gaps = 360/1544 (23%)
Query: 7 PREMRKTFIVPAIKPFDHYDFSRAKIACNLAWLVAKAFG-TENVPEELQEPFYTDQYDQE 65
P +R+TF+VP IK D YDFSRAK A +LAW++ AFG E+VP EL EPFYTDQY QE
Sbjct: 9 PGPLRRTFLVPEIKSLDQYDFSRAKAAASLAWVLRAAFGGAEHVPPELWEPFYTDQYAQE 68
Query: 66 HIKPPVVNLLLSAELYCRAGSLILKSDAAKPLLGHDAVIQALAQKGLYVTDQEKLVTERD 125
H+KPPV LLLSAELYCRA L P A++ LA++G E+ V E D
Sbjct: 69 HVKPPVTRLLLSAELYCRAWRQALPQLETPP--NPSALLALLARRGTVPALPERPVREAD 126
Query: 126 LHKKPIQMSAHLAMIDTLMMAYTVEMV-SIEKVIACAQQYSAFFQATDLPYDIEDAVMYW 184
L +PI M AHLA+ID LM A+ E ++ +A +E +++W
Sbjct: 127 LRHQPILMGAHLAVIDALMAAFAFEWTKTLPGPLALTS--------------LEHKLLFW 172
Query: 185 INKVNEHLKDIMEQEQKLKEHHTVEAPGGQKA---------------------------- 216
++ L++ EQE + A G A
Sbjct: 173 VDTTVRRLQEKTEQEAAQRASPAAPADGAAPAQPSCPTRWYWKLVPHAIAFCLKESGSKP 232
Query: 217 ---RYRKEQTLLKQLPCIPLVENLLKDGTDGCALAALIHFYCPDVVRLEDICLKETMSLA 273
RYRK++ + ++ PC P V +L +D G ALAA IH YCP ++RLE++CLK+ MS+A
Sbjct: 233 PMIRYRKDRVVARRAPCFPTVTSL-QDLASGAALAATIHCYCPQLLRLEEVCLKDPMSVA 291
Query: 274 DSLYNLQLIQEFCQEYLNQCCHFTLEDMLYAASSIKSNYLVFMAELFWWFEVVKPSFVQP 333
DSLYNLQL+Q+FC L + C +LED+LY +K N +V +AELF FEV+KP FVQ
Sbjct: 292 DSLYNLQLVQDFCASRLPRGCPLSLEDLLYVPPPLKVNLVVMLAELFMCFEVLKPDFVQ- 350
Query: 334 RVVRPQGAEPVKDMPSIPVLNAAKRNVLDSSSDFPSSGEGATFTQSHHHLPSRYSRPQAH 393
VKD+P +AA ++S +SG + H L S
Sbjct: 351 ----------VKDLPDG---HAASPRGTEASPPQNNSGSSSPVFTFRHPLLS-------- 389
Query: 394 SSASGGIRRSSSMSYVDGFIGTWPKEKRSSVHGVSFDISFDKEDSVQRSTPNRGITRSIS 453
SGG + +P RG T S+
Sbjct: 390 ---SGGPQ-----------------------------------------SPLRGSTGSLK 405
Query: 454 NEGLTLNNSHVSKHIRKNLSFKPINGEEEAESIEEELNIDSHSDLKSCVPLNTNELNSNE 513
+ + + K + LS +P++ +A S +DS D+ P+ ++S +
Sbjct: 406 SSPSMSHMEALGKAWNRQLS-RPLS---QAVSFSTPFGLDSDVDVVMGDPVLLRSVSS-D 460
Query: 514 NIHYKLPNGALQNRILLDEFGNQIETPSIEEALQIIHDTEKSPHTPQPDQIANG-FFLHS 572
++ P A E G + P+IEEALQIIH E PD A+G F+LHS
Sbjct: 461 SLGPPRPAPARTPTQPPPEPG---DLPTIEEALQIIHSAEPRL---LPDGAADGSFYLHS 514
Query: 573 QEMSILNSNIKLNQSSPDNVTD--TKGALSPITDNTEVDTGIHVPSEDIPETMDEDSSLR 630
E S P + +G P++D +++P PET + S
Sbjct: 515 PE----------GPSKPSLASPYLPEGTSKPLSDRP-TKAPVYMPH---PETPSKPSPCL 560
Query: 631 DYTVSLDSDMDDASKFLQDYDIRTGNTREALSPCPSTVSTKSQPGSSASSSSGVKMTSFA 690
+ +ASK P PS S K+ S A+++S VKMTSFA
Sbjct: 561 ---------VGEASK----------------PPAPSEGSPKAVASSPAATNSEVKMTSFA 595
Query: 691 EQKFRKLNHTDGKSSGSSSQKTTPEGSELNIPHVVAWAQIPEETGLPQGRDTTQLLASEM 750
E+K ++L + ++ G+ S +TP E L+SEM
Sbjct: 596 ERK-KQLVKAEAEA-GAGSPTSTPAPPEA--------------------------LSSEM 627
Query: 751 VHLRMKLEEKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGISPLREEAAGAED 810
L +LEEKRRAIEAQK+++EA F K RQ++G++AFL V ++ G A AE
Sbjct: 628 SELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASG-------EAEAEA 680
Query: 811 EKVYTDRAKEKESQKTDGQRSKSLADIKESMENPQAKWLKSPTTPIDPEKQWNLASPSEE 870
E+ + E +GQ E P+A P+ E
Sbjct: 681 EEADSGPVPGGERPAGEGQG--------EPTSRPKAVTFSPDLGPVPHEG---------- 722
Query: 871 TLNEGEILEYTKSIEKLNSSLHFLQQEMQRLSLQQEMLMQMREQQSWVISPPQPSPQKQI 930
+ EY +++ KL+++L LQ++MQRL+ QQ+ L+ +PP+
Sbjct: 723 ------LGEYNRAVSKLSAALSSLQRDMQRLTDQQQRLL----------APPEA------ 760
Query: 931 RDFKPSKQAGLSSAIAPFSSDSPRPTHPSPQSSNRKSASFSVKSQRTPRPNELKITPLNR 990
P ++ + P + P+ PSP + R A+ +R+P P + +P +
Sbjct: 761 ----PGSAPPPAAWVIPGPTTGPKAASPSP--ARRVPAT-----RRSPGPGPSQ-SPRSP 808
Query: 991 TLTPPRSVDSLPRLRRFSPSQVPIQTRSFVCFGDDGEPQLKESKPKEEVKKEELESKGTL 1050
T P + P R +P D P L++ P +
Sbjct: 809 KHTRPAELRLAPLTRVLTPPH-----------DVDSLPHLRKFSPSQV------------ 845
Query: 1051 EQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLTPNEDQLNQPTEPPPKPVFPPTAPKNV 1110
P ++ S +L+ + P EP +P
Sbjct: 846 -------------PVQTRSSILLA--------------EETPPEEPAARP---------- 868
Query: 1111 NLIEVSLSDLKPPEKADV----PVEKYDGESDKEQFDDDQKVCCGFFFKDDQKAENDMAM 1166
LIE+ L L P D P D ++ + + +V GFF+KD+ K E++MA
Sbjct: 869 GLIEIPLGSLADPAAEDEGDGSPAGAEDSLEEEASSEGEPRVGLGFFYKDEDKPEDEMAQ 928
Query: 1167 KRAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEE------------------- 1207
KRA+LLE++ RR +E + RKQ E E E ++EE R +EE
Sbjct: 929 KRASLLERQQRRAEEARRRKQWQEVEKEQRREEAARLAQEEAPGPAPLVSAVPMATPAPA 988
Query: 1208 -RQKKEDERARR--EFIRQEYMRRKQLKLMEDMDTVIKPR------PQVVKQKKQRPKSI 1258
R E+E R +F RQEY RR QLKLM+D+D V++PR P ++ RP+S
Sbjct: 989 ARAPAEEEVGPRKGDFTRQEYERRAQLKLMDDLDKVLRPRAAGSGGPGRGGRRATRPRSG 1048
Query: 1259 HRDHIESPKTPIKG------PPVSSLSLASLNTGDNESVHS---GKRTPRSESVEGFLSP 1309
D ++P +G + S S SL+T NE+ ++ + T R+ S G +SP
Sbjct: 1049 CCDDSALARSPARGLLGSRLSKIYSQSTLSLSTVANEAHNNLGVKRPTSRAPSPSGLMSP 1108
Query: 1310 SRC-GSRNGEKDWENASTTSSVASGTEYTGPKLYKEPSAKSNKHIIQNALAHCCLAGKVN 1368
SR GSR E+DWEN S SS AS EYTGP+LYKEPSAKSNK II NAL+HCCLAGKVN
Sbjct: 1109 SRLPGSR--ERDWENGSNASSPASVPEYTGPRLYKEPSAKSNKFIIHNALSHCCLAGKVN 1166
Query: 1369 EGQKKKILEEMEKSDANNFLILFRDSGCQFRSLYTYCPETEEINKLTGIGPKSITKKMIE 1428
E QK +ILEE+EKS AN+FLILFRDS CQFR+LYT ETEE+++L G GP+++T M+E
Sbjct: 1167 EPQKNRILEEIEKSKANHFLILFRDSSCQFRALYTLSGETEELSRLAGYGPRTVTPAMVE 1226
Query: 1429 GLYKYNSDRKQFSHIPAKTLSASVDAITIHSHLWQTKRPVTPKK 1472
G+YKYNSDRK+F+ IPAKT+S SVDA TI HLWQ K+P TPKK
Sbjct: 1227 GIYKYNSDRKRFTQIPAKTMSMSVDAFTIQGHLWQGKKPTTPKK 1270
>gi|186659512 calmodulin regulated spectrin-associated protein 1 [Homo
sapiens]
Length = 1602
Score = 561 bits (1445), Expect = e-159
Identities = 387/921 (42%), Positives = 520/921 (56%), Gaps = 89/921 (9%)
Query: 584 LNQSSPDNVTDTKGALSPITDNTEVDTGIHVPSEDIPETMDEDSSLRDYTVSLDSDMDDA 643
L Q S +V D + A E+ + ED ++++ D DDA
Sbjct: 734 LRQDSDSDVVDIEEAEHDFMGEAHPVVFSRYIGEEESAKLQEDMKVKEH-----EDKDDA 788
Query: 644 SKFLQDYDIRTGNTREALSPCPSTVSTKSQPGSSASSSSGVKMTSFAEQKFRKLNHTDGK 703
S G + SPC +ST SQ S + +S VKMTSFAE+K ++LN + K
Sbjct: 789 S----------GRS----SPC---LSTASQMSSVSMASGSVKMTSFAERKLQRLNSCETK 831
Query: 704 SSGSSSQKTTPEGSELNIPHVVAWAQIPEETGLPQGRDTTQLLASEMVHLRMKLEEKRRA 763
SS SSSQKTTP+ SE + W Q E++ G+D LLASE+V L M+LEEKRRA
Sbjct: 832 SSTSSSQKTTPDASESCPAPLTTWRQKREQSPSQHGKDPASLLASELVQLHMQLEEKRRA 891
Query: 764 IEAQKKKMEAAFTKQRQKMGRTAFLTVVKK-KGDGISPLREEAAGAE----------DEK 812
IEAQKKKMEA +QR K+G+ AFL VVKK K + PLR E E D
Sbjct: 892 IEAQKKKMEALSARQRLKLGKAAFLHVVKKGKAEAAPPLRPEHFAKEYSQHNGEDCGDAV 951
Query: 813 VYTDRAKEKESQKTDGQRSKSLADIKESMENPQAKWLKSPTTPIDPEKQWNL-ASPSEET 871
T+ KE Q+ + D KES+ Q K P + E+ + A+ E+T
Sbjct: 952 SKTEDFLVKEEQREELLHEPQDVD-KESLAFAQQHKAKDPVALHELERNKVISAALLEDT 1010
Query: 872 LNEG-EILEYTKSIEKLNSSLHFLQQEMQRLSLQQEMLMQMREQQSWVISPPQPSPQKQI 930
+ E ++ E SIEKLN ++ LQQ + ++S QQE L+ SP P P
Sbjct: 1011 VGEVVDVNECDLSIEKLNETISTLQQAILKISQQQEQLLMK--------SPTVPVPGS-- 1060
Query: 931 RDFKPSKQAGLSSAIAPFSSDSPRPTHPSPQSSNRKSASFSV-KSQRTPRPNELKITP-- 987
K + Q A F P P+ + +RK+ ++ R+ RP ELK+
Sbjct: 1061 ---KNNSQDHKVKAPVHFVE----PLSPTGVAGHRKAPRLGQGRNSRSGRPAELKVPKDR 1113
Query: 988 ---LNRTLTPPRSVDSLPRLRRFSPS---QVPIQTRSFVCFGDDGEPQLKESKPKEEVKK 1041
+R+ TP SV++LP LR F S + P G+P K +
Sbjct: 1114 PQGSSRSKTPTPSVETLPHLRPFPASSHPRTPTDPGLDSALEPSGDPHGKCLFDSYRLHD 1173
Query: 1042 EELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLTPNEDQLNQPTEPPPKPV 1101
E + TL + ++ I + ++ EVL V E + + D + + P +P+
Sbjct: 1174 ESNQRTLTLS----SSKDANILSEQMSLKEVLDASVKEVG--SSSSDVSGKESVPVEEPL 1227
Query: 1102 FPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGESDKEQFDDDQKVCCGFFFKDDQKAE 1161
+LIEV LSDLK P++ D + DG +D + DQK GFFFKD+QKAE
Sbjct: 1228 -----RSRASLIEVDLSDLKAPDE-DGELVSLDGSADLVS-EGDQKPGVGFFFKDEQKAE 1280
Query: 1162 NDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKKEDERARREFI 1221
+++A KRAA L K+ R+ +E ++RKQQLEAE+E K++E RRK EE+R +KE+E+ARRE I
Sbjct: 1281 DELAKKRAAFLLKQQRKAEEARVRKQQLEAEVELKRDEARRKAEEDRVRKEEEKARRELI 1340
Query: 1222 RQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHI---------ESPKTPIKG 1272
+QEY+RRKQ +++E+ + KP+ K KK RPKS+HR+ +P +
Sbjct: 1341 KQEYLRRKQQQILEEQG-LGKPKS---KPKKPRPKSVHREESCSDSGTKCSSTPDNLSRT 1396
Query: 1273 PPVSSLSLASLNTGDNESVHSGKR-TPRSESVEGFLSPSRCGSRNGEKDWENASTTSSVA 1331
SSLSLAS T + ESVHSG + R ES+E SR SR+ ++DWE AS SS+A
Sbjct: 1397 QSGSSLSLASAATTEPESVHSGGTPSQRVESMEALPILSRNPSRSTDRDWETASAASSLA 1456
Query: 1332 SGTEYTGPKLYKEPSAKSNKHIIQNALAHCCLAGKVNEGQKKKILEEMEKSDANNFLILF 1391
S EYTGPKL+KEPS+KSNK II NA++HCCLAGKVNE K ILEE+EK DAN+++ILF
Sbjct: 1457 SVAEYTGPKLFKEPSSKSNKPIIHNAISHCCLAGKVNEPHKNSILEELEKCDANHYIILF 1516
Query: 1392 RDSGCQFRSLYTYCPETEEINKLTGIGPKSITKKMIEGLYKYNSDRKQFSHIPAKTLSAS 1451
RD+GCQFR+LY Y P+TEEI KLTG GPK+ITKKMI+ LYKY+SDRKQF+ IPAKT+S S
Sbjct: 1517 RDAGCQFRALYCYYPDTEEIYKLTGTGPKNITKKMIDKLYKYSSDRKQFNLIPAKTMSVS 1576
Query: 1452 VDAITIHSHLWQTKRPVTPKK 1472
VDA+TIH+HLWQ KRP PKK
Sbjct: 1577 VDALTIHNHLWQPKRPAVPKK 1597
Score = 415 bits (1067), Expect = e-115
Identities = 226/488 (46%), Positives = 310/488 (63%), Gaps = 56/488 (11%)
Query: 21 PFDHYDFSRAKIACNLAWLVAKAFGTENVPEELQEPFYTDQYDQEHIKPPVVNLLLSAEL 80
P D YD +RAKIA NL W+ AKA+G +N+PE+L++PFY DQY+QEHIKPPV+ LLLS+EL
Sbjct: 28 PLDRYDAARAKIAANLQWICAKAYGRDNIPEDLRDPFYVDQYEQEHIKPPVIKLLLSSEL 87
Query: 81 YCRAGSLILKSDAAKPLLGHDAVIQALAQKGLYVTDQEKL-VTERDLHKKPIQMSAHLAM 139
YCR SLILK D L GH +VIQAL++KG+YV + + VTE DL + PI+MSAH+AM
Sbjct: 88 YCRVCSLILKGDQVAALQGHQSVIQALSRKGIYVMESDDTPVTESDLSRAPIKMSAHMAM 147
Query: 140 IDTLMMAYTVEMVSIEKVIACAQQYSAFFQATDLPYDIEDAVMYWINKVNEHLKDIMEQE 199
+D LMMAYTVEM+SIEKV+A +++S F + +LPYD+EDA+++WINKVN +++I E+E
Sbjct: 148 VDALMMAYTVEMISIEKVVASVKRFSTFSASKELPYDLEDAMVFWINKVNLKMREITEKE 207
Query: 200 QKLKEHHTVEAPGGQKARYRKEQTLLKQLPCIPLVENLLKDGTDGCALAALIHFYCPDVV 259
KLK+ +E+P QK RYR+E +Q P PL+E+L++DG+DG AL A+IH+YCP+ +
Sbjct: 208 VKLKQQ-LLESPAHQKVRYRREHLSARQSPYFPLLEDLMRDGSDGAALLAVIHYYCPEQM 266
Query: 260 RLEDICLKETMSLADSLYNLQLIQEFCQEYLNQCCHFTLEDMLYAASSIKSNYLVFMAEL 319
+L+DICLKE S+ADSLYN++L++EF EYLN+C + TLEDMLYA +K N +VF+AEL
Sbjct: 267 KLDDICLKEVTSMADSLYNIRLLREFSNEYLNKCFYLTLEDMLYAPLVLKPNVMVFIAEL 326
Query: 320 FWWFEVVKPSFVQPRVVRP-QGAEPV----KDMPSIPVLNAAKRNVLDSSS--------- 365
FWWFE VKP FVQPR V+ + A+ V P +P+ NA KR+ L S +
Sbjct: 327 FWWFENVKPDFVQPRDVQELKDAKTVLHQKSSRPPVPISNATKRSFLGSPAAGTLAELQP 386
Query: 366 --DFPSSG----------------EGATFTQSHHHLPSRYSRPQA--HSSASGGIRRSSS 405
P+ G A F+ SH LP R + ++ RS+S
Sbjct: 387 PVQLPAEGCHRHYLHPEEPEYLGKGTAAFSPSHPLLPLRQKQQKSIQGEDIPDQRHRSNS 446
Query: 406 MSYVD----GFIGTWPKEKRSSV---------HGVSFDISFDKEDSVQRSTPNRGITRSI 452
++ VD G WP++K H S ++ DS+ + RSI
Sbjct: 447 LTRVDGQPRGAAIAWPEKKTRPASQPTPFALHHAASCEVDPSSGDSI-------SLARSI 499
Query: 453 SNEGLTLN 460
S + L N
Sbjct: 500 SKDSLASN 507
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 70.1 bits (170), Expect = 2e-11
Identities = 114/569 (20%), Positives = 215/569 (37%), Gaps = 68/569 (11%)
Query: 715 EGSELNIPHVVAWAQIPEETGLPQGRDTTQLLASEMVHLRMKLEEKRRAIEAQKKKMEAA 774
EG E I +PE GLP+ + S H+++K EEK + +E +K+
Sbjct: 407 EGEECRIGFGPIPFSLPE--GLPK-------IPSVSTHIKVKSEEKIKVVEKSEKET-VI 456
Query: 775 FTKQRQKMGRTAFLTVVKKKGDGISPLREEAAGAEDEKVYTDR-----------AKEKES 823
+Q ++ T +T ++K +EE G E+E + + EKE+
Sbjct: 457 VEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEA 516
Query: 824 QKTDGQRSKSLADIKESMENPQAKWLKSPTTPIDPEKQWNLASPSEETLNEGEILEYTKS 883
+ + +KS A+ K +P+ + KSP PEK SP++E E + KS
Sbjct: 517 KSPVKEEAKSPAEAK----SPEKEEAKSPAEVKSPEKA---KSPAKE---EAKSPPEAKS 566
Query: 884 IEK--LNSSLHFLQQEMQRLSLQQEMLMQMREQQSWVISPPQPSPQKQIRDFK-PSKQAG 940
EK S E + ++E + P K + K P K+
Sbjct: 567 PEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEA 626
Query: 941 LSSAIAPFSSDSPRPTHPSPQSSNRKSASFSVKSQRTPRPNELKITPLNRTLTPPRSVDS 1000
S A + PT +S + S + + P + K +P+ P S
Sbjct: 627 KSPAEVKSPEKAKSPTKEEAKSPEKAK---SPEKEEAKSPEKAK-SPVKAEAKSPEKAKS 682
Query: 1001 LPRLRRFSPSQVPIQTRSFVCFGDDGEPQLKESKPKEEVKKEELESKGTLEQRGHNPEEK 1060
+ SP + + + + +KE E K ++ + ++ +P ++
Sbjct: 683 PVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKE 742
Query: 1061 EIKPFESTVS--EVLSLPVTETVCLTPNEDQLNQPTEPPPKPVFPPTAPKNVNLIEVSLS 1118
E K E S + +L V TP +++ P + P+ P
Sbjct: 743 EAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVK-----------E 791
Query: 1119 DLKPPEKADVPVEKYDGESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRR 1178
++K PEKA P+ K D ++ +++ ++V K+++K + +
Sbjct: 792 EVKSPEKAKSPL-KEDAKAPEKEIPKKEEVKSPV--KEEEKPQEV--------------K 834
Query: 1179 EKETQLRKQQLEAEMEHKKEETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMD 1238
KE + ++ +A K EE + +EE KKE + + E ++ + + + +E
Sbjct: 835 VKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKK 894
Query: 1239 TVIKPRPQVVKQKKQRPKSIHRDHIESPK 1267
+ + +V +K+ P + PK
Sbjct: 895 EEAEDKKKVPTPEKEAPAKVEVKEDAKPK 923
Score = 50.4 bits (119), Expect = 1e-05
Identities = 108/529 (20%), Positives = 207/529 (39%), Gaps = 74/529 (13%)
Query: 766 AQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGISPLREEAAGAEDEKVYTDRAKEKESQK 825
A + +M+A T+ K T+ L ++ + +G + ++ E +V DR E
Sbjct: 250 AAQAQMQAE-TRDALKCDVTSALREIRAQLEGHA-VQSTLQSEEWFRVRLDRLSEAAKVN 307
Query: 826 TDGQRSKSLADIKESMENPQAKW-----LKSPTTPIDPEKQWNLASPSEETLNEGEILEY 880
TD RS +I E QA+ LKS ++ ++ E ++ +I Y
Sbjct: 308 TDAMRSAQ-EEITEYRRQLQARTTELEALKSTKDSLERQRS------ELEDRHQADIASY 360
Query: 881 TKSIEKLNSSLHFLQQEMQRLSLQQEMLMQMREQQSWV-ISPPQPSPQKQIRDFKPSKQA 939
++I++L++ L + + EM Q+RE Q + + R ++
Sbjct: 361 QEAIQQLDAELR---------NTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEEC 411
Query: 940 GLSSAIAPFSSDSPRPTHPSPQSSNRKSASFSVKSQRTPRPNELKITPLNRTLTPPRSVD 999
+ PFS P PS S VKS+ KI + ++ V+
Sbjct: 412 RIGFGPIPFSLPEGLPKIPSV------STHIKVKSEE-------KIKVVEKSEKETVIVE 458
Query: 1000 SLPRLRRFSPSQVPIQTRSFVCFGDDGEPQLKESKPKEEVKKEELESKGTLEQRGHNPEE 1059
+ +QV + ++ E + KE + KEE EE E++G E+ P E
Sbjct: 459 E-----QTEETQVTEEVT------EEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAE 507
Query: 1060 KEIKPFESTVSEVLSLPVTETVCLTPNEDQLNQPTE---------PPPKPVFPPTAPKNV 1110
+ P + S V + +P +++ P E P + P K+
Sbjct: 508 EAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSP 567
Query: 1111 NLIEV-SLSDLKPPEKADVPVEKYDGESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRA 1169
E S +++K PEKA P K + +S E ++ K K E +
Sbjct: 568 EKEEAKSPAEVKSPEKAKSPA-KEEAKSPAEAKSPEKA-------KSPVKEEAKSPAEAK 619
Query: 1170 ALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKKEDERARREFIRQEYMRRK 1229
+ +++ + E + ++ E K + K+ E+ + K E+A+ ++ E +
Sbjct: 620 SPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSP-VKAEAKSPE 678
Query: 1230 QLK--LMEDMDTVIKPRPQVVKQKK--QRPKSIHRDHIESP---KTPIK 1271
+ K + + + K + V ++ K ++ KS ++ +SP K+P+K
Sbjct: 679 KAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVK 727
>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
Length = 904
Score = 58.5 bits (140), Expect = 5e-08
Identities = 108/492 (21%), Positives = 186/492 (37%), Gaps = 88/492 (17%)
Query: 809 EDEKVYTDRAKEKESQKTDGQRSKSLADIKESMENPQAKWLKSP-----TTPIDPE-KQW 862
E EK+ + + ++++ K D + +S + +E +P+ + +SP ++P+ E K+
Sbjct: 137 EQEKLASMKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRS 196
Query: 863 NLASPSEETLNEGEI---LEYTKSIEKLNSSLHFLQQEMQRLSLQQEMLMQMREQQSWVI 919
+ SP T + + K+ E S+ + +Q + ++L + + +
Sbjct: 197 HSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEP--IP 254
Query: 920 SPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPR---PTHPSPQSSNRKSASFSVKSQR 976
P +PSP+K + K ++ S S R P+H P+ +R S S S +R
Sbjct: 255 EPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHR-SRSRSYSPRR 313
Query: 977 TPRPNELKITPLNRTLTPPRSVDSLPRLRRFSPSQVPIQTRSFVCFGDDGEPQLKESKPK 1036
P P P R TPPR + PR RR S+ P++ R G
Sbjct: 314 RPSPRR---RPSPRRRTPPRRMPPPPRHRR---SRSPVRRRRRSSASLSG---------- 357
Query: 1037 EEVKKEELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLTPN------EDQL 1090
S + R +P +K K S P +T L+P+ +
Sbjct: 358 --------SSSSSSSSRSRSPPKKPPKRTSS--------PPRKTRRLSPSASPPRRRHRP 401
Query: 1091 NQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGESDKEQ---FDDDQK 1147
+ P PPPK PT P+ N S + P + V K+ G +E +K
Sbjct: 402 SPPATPPPKTRHSPT-PQQSNRTRKSRVSVS-PGRTSGKVTKHKGTEKRESPSPAPKPRK 459
Query: 1148 VCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEE 1207
V + ++E D K AA + RR Q R+Q ++ + +
Sbjct: 460 V-------ELSESEEDKGGKMAAADSVQQRR----QYRRQNQQSSSDSGSSSS------- 501
Query: 1208 RQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHIESPK 1267
EDER +R ++ + R++ P P+ +QK+ P+ R P
Sbjct: 502 ---SEDERPKRSHVKNGEVGRRR---RHSPSRSASPSPR-KRQKETSPRGRRRRSPSPPP 554
Query: 1268 T-----PIKGPP 1274
T P PP
Sbjct: 555 TRRRRSPSPAPP 566
Score = 35.4 bits (80), Expect = 0.41
Identities = 56/262 (21%), Positives = 97/262 (37%), Gaps = 48/262 (18%)
Query: 912 REQQSWVISPPQPS-PQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSPQSSN-----R 965
+++ S V PS K + PS+ + + P SP P +PQ+S+ R
Sbjct: 642 KQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVR 701
Query: 966 KSASFSVKSQRTPRPNELKITPLNRTLTP----------PRSVDSLPRLRRFSPS----- 1010
+ AS S + +++P P+ I ++RT P P+SV + R S S
Sbjct: 702 RGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAA 761
Query: 1011 ------QVPIQTRSFVCFGDDGEPQLKESKP----------------KEEVKKEELESKG 1048
P+Q++S P K P K++ KK++ + K
Sbjct: 762 KKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSDQEGGGKKKKKKKDKKHKK 821
Query: 1049 TLEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLTPNEDQLNQPTEPPPKPVFPPTAPK 1108
+ + H +KE + + V + E+ + P PK A
Sbjct: 822 DKKHKKHKKHKKEKAVAAAAAAAVTPAAIAAATTTLAQEEPV---AAPEPKKETESEAED 878
Query: 1109 NVNLIEVSLSD--LKPPEKADV 1128
N++ +E L + L+ KA V
Sbjct: 879 NLDDLEKHLREKALRSMRKAQV 900
Score = 35.0 bits (79), Expect = 0.54
Identities = 43/183 (23%), Positives = 72/183 (39%), Gaps = 19/183 (10%)
Query: 924 PSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSPQSSNRKSASFSVKSQRTPRPNEL 983
PSP+K+ ++ P + S + P + R P+P R++ + + +RTP P
Sbjct: 531 PSPRKRQKETSPRGRRRRSPSPPP--TRRRRSPSPAPPPRRRRTPTPPPR-RRTPSPPPR 587
Query: 984 KITPLNRTLTPPRSVDSLPRLRRFSPSQVPIQTRSFVCFGDDGEPQLKESKPKEEVKKEE 1043
+ +P R +PP RR+SPS P + + P + + P K+
Sbjct: 588 RRSPSPRRYSPPIQ-------RRYSPSPPPKRRTA-----SPPPPPKRRASPSPPPKRRV 635
Query: 1044 LESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLTPNEDQLNQPTEPPPKPVFP 1103
S ++ +P K P S+ S P T Q N+ P P+P P
Sbjct: 636 SHSPPPKQR--SSPVTKRRSPSLSSKHRKGSSPSRST--REARSPQPNKRHSPSPRPRAP 691
Query: 1104 PTA 1106
T+
Sbjct: 692 QTS 694
Score = 32.7 bits (73), Expect = 2.7
Identities = 38/193 (19%), Positives = 75/193 (38%), Gaps = 32/193 (16%)
Query: 1164 MAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKKEDERA-RREFIR 1222
+ +K+ + ++++ +EK ++KQ E K + + + E R+K+E R+ RR R
Sbjct: 124 LELKKEEIKQRQIEQEKLASMKKQD-----EDKDKRDKEEKESSREKRERSRSPRRRKSR 178
Query: 1223 QEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHIESPKTPIKGP--------- 1273
RR R V+++++R S H ++P P
Sbjct: 179 SPSPRR---------------RSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKTPEL 223
Query: 1274 PVSSLSLASLNTGDNESVHSGKRTPRSESVEGFLSPSRCGSRNGEKDWENASTTSSVASG 1333
P S+ + + + S + P+ E + PS +N +K+ E T S
Sbjct: 224 PEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPS--PEKNSKKEKEKEKTRPRSRSR 281
Query: 1334 TEYTGPKLYKEPS 1346
++ + PS
Sbjct: 282 SKSRSRTRSRSPS 294
>gi|171184451 centrosome-associated protein 350 [Homo sapiens]
Length = 3117
Score = 56.2 bits (134), Expect = 2e-07
Identities = 184/895 (20%), Positives = 322/895 (35%), Gaps = 186/895 (20%)
Query: 617 EDIPETMDE------DSSLRDYTVSLDSDMDDASKFLQDYDIRTGNTREALSPCPSTVST 670
E I ++DE D SLR +V D D++ +Y ++ S
Sbjct: 1567 EKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDE---------SMTED 1617
Query: 671 KSQPGSSASSSSGVKMTSFAEQKFRKLNHTDGKSSGSSSQKTTPEGSELNIPHVVAWAQI 730
+ + S S F +K R+ +H D S + T ELN+P
Sbjct: 1618 EIEEQSFRSLLPSESHRRFNMEK-RRGHHDDSDEEASPEKTTLSTAKELNMP-------- 1668
Query: 731 PEETGLPQGRDTTQLLASEMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTV 790
G+D+ EMV MK EE R A ++ ++ K++ K A+L
Sbjct: 1669 -----FSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTK-AELAWLEH 1722
Query: 791 VKKKGDGISPLREEAAGAEDEKVYTDRAKEKESQKTDGQRSKSLADIKESMENPQAKWLK 850
KK LR++ ED+K+ R K++ Q + ++E+
Sbjct: 1723 QKKH------LRDKG---EDDKMPPLRKKQRGLLLRLQQEKAEIKRLQEA---------- 1763
Query: 851 SPTTPIDPEKQWNLASPSEETLNEGEILEYTKSIEKLNSSLHFLQQEMQRLSLQQEMLMQ 910
N A+ E L IL+ + IEK+ + LQ++++ S + L
Sbjct: 1764 ------------NKAARKERQL----ILKQQEEIEKIRQTTIKLQEKLK--SAGESKLDS 1805
Query: 911 MREQQSWVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSPQSSNRKSASF 970
+ D K +K +++ P ++ P+ S SS S
Sbjct: 1806 HSDD-----------------DTKDNK----ATSPGPTDLETRSPSPISISSSETSSIMQ 1844
Query: 971 SVKSQRTPRPNELKITPLNRTLTPPR--SVDSLPRLRRFSPSQVPIQTRSFVCFGDDGEP 1028
+K R+ R +E +T + L R + + L RR + I+ +
Sbjct: 1845 KLKKMRS-RMDEKFLTKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKE 1903
Query: 1029 QLKESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPF-----ESTVSEVLSLPVTETVCL 1083
+K PK+E++ + E K + EE + + ES++ E L P E V
Sbjct: 1904 LIKPKTPKKELEDQRTEQKEIASE-----EESPVPLYSHLNSESSIPEELGSPAVEYV-- 1956
Query: 1084 TPNED----------------------QLNQPTEPPPKPVFPPTAPKNVNLIEVSLSDLK 1121
P+E +L T P + P + +V+ E S +
Sbjct: 1957 -PSESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSL--PKSCTSVSKQESSKGSHR 2013
Query: 1122 PPEKADVPVEKYDGESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKE 1181
+ +P++ + + D+ + D E + RA E R R+
Sbjct: 2014 TGGQCHLPIKSH--QHCYSWSDESLSMTQSETTSDQSDIEGRI---RALKDELRKRKSVV 2068
Query: 1182 TQLRKQQLEAEMEHKKEETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDT-- 1239
QL+K+Q K+++ R K +E K+ E E++++ + +L +D++T
Sbjct: 2069 NQLKKEQ------KKRQKERLKAQEASLIKQLES------YDEFIKKTEAELSQDLETSP 2116
Query: 1240 VIKPRPQVVKQKKQRPKSIHRDHIESPKTPIKGPPVS----SLSLASLNTGDNESV--HS 1293
KP+ + + ++PK P TP+ + SL+ + + G ES+ H
Sbjct: 2117 TAKPQIKTLSSASEKPKI-------KPLTPLHRSETAKNWKSLTESERSRGSLESIAEHV 2169
Query: 1294 GKRTPRSESVEGFLSPSRCGSRNGEKD--WENASTTSSVASGT----EYTGPKLYKEPSA 1347
SE S S R E D E+ T S V + E +G L P+
Sbjct: 2170 DASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREESGDSLENVPAL 2229
Query: 1348 KSNKHIIQNALAHCCLAGKVNEGQKKKILEEME-----------------KSDANNFLIL 1390
K + + GKV E KK ++E+E KSD L+L
Sbjct: 2230 HLLKELNATSRILDMSDGKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVLLKLVL 2289
Query: 1391 FRDSGCQFRSLYTYCPETEEINK-LTGIGPKSITKKMIEGLYKYNSDRKQFSHIP 1444
+ + S ++E + K L G+ +++ K E + K + +H P
Sbjct: 2290 EQGDSSEILSKKDLPLDSENVQKDLVGLAIENLHKS--EEMLKERQSDQDMNHSP 2342
>gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 55.5 bits (132), Expect = 4e-07
Identities = 126/573 (21%), Positives = 224/573 (39%), Gaps = 112/573 (19%)
Query: 746 LASEMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGISPLR--- 802
L E +R KLEEK R EAQ+ ++RQ+ GR T+ K + + +
Sbjct: 111 LRYEEAEVRKKLEEKDRQEEAQR------LQQKRQETGREDGGTLAKGSLENVLDSKDKT 164
Query: 803 EEAAGAEDEKVYTDR-----AKEKESQKTDGQRSKSLADIKESMENPQAKWLKSPTTP-- 855
+++ G ++EK T AKE + TD S + D + + + L S + P
Sbjct: 165 QKSNGEKNEKCETKEKGAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEE 224
Query: 856 -IDP--EKQW---NLASPSEETLNEGEILEYTKSIE--------KLNSSLHFLQQEM--- 898
I P W +L S++T + +EY ++ ++ ++L L+ +
Sbjct: 225 AISPGVTASWIEAHLPDDSKDTWKKRGNVEYVVLLDWFSSAKDLQIGTTLRSLKDALFKW 284
Query: 899 -QRLSLQQEMLMQMREQQSWVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTH 957
+ L+ E L+ ++W++ PQ + ++ P +Q S F+ S +
Sbjct: 285 ESKTVLRNEPLVLEGGYENWLLCYPQYTTNAKVTP-PPRRQNEEVSISLDFTYPSLEESI 343
Query: 958 PSPQSSNRKSASFSVKSQRTPRPNELKITPLNRTLTPPRSVDSLPRLRRFSPSQVPIQTR 1017
PS ++ AS V N I+ N + P L +P + ++
Sbjct: 344 PSKPAAQTPPASIEVDE------NIELISGQNERMGP---------LNISTPVEPVAASK 388
Query: 1018 SFVCFGDDGEPQLKESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPV 1077
S V P +K + KK ++ PEE IK EST E S
Sbjct: 389 SDVSPIIQPVPSIKNVPQIDRTKKPAVKL----------PEEHRIKS-ESTNHEQQSPQS 437
Query: 1078 TETVCLTPNEDQLNQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGES 1137
+ + D+ +P VF PT + L+D EKA + E
Sbjct: 438 GKVI-----PDRSTKPV------VFSPT---------LMLTD---EEKARIHAET----- 469
Query: 1138 DKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKK 1197
+ K E ++ ++ +++LR+E++ Q K++ EAE E++
Sbjct: 470 --------------ALLMEKNKQEKELRERQQEEQKEKLRKEEQEQKAKKKQEAE-ENEI 514
Query: 1198 EETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKS 1257
E ++K +EE +KKE E+A++E R K++ T +K + + + KS
Sbjct: 515 TEKQQKAKEEMEKKESEQAKKEDKETSAKRGKEI-------TGVKRQSKSEHETSDAKKS 567
Query: 1258 IHRDHIESPKTPIKGPPVSSLSLASLNTGDNES 1290
+ P I+ + S+ TGD+ S
Sbjct: 568 VEDRGKRCPTPEIQKKSTGDVPHTSV-TGDSGS 599
Score = 32.0 bits (71), Expect = 4.5
Identities = 27/124 (21%), Positives = 55/124 (44%), Gaps = 6/124 (4%)
Query: 1182 TQLRKQQLEAE----MEHKKEETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDM 1237
T K ++ AE ME K+E ++ E +Q+++ E+ R+E Q+ ++++ + E
Sbjct: 458 TDEEKARIHAETALLMEKNKQE--KELRERQQEEQKEKLRKEEQEQKAKKKQEAEENEIT 515
Query: 1238 DTVIKPRPQVVKQKKQRPKSIHRDHIESPKTPIKGPPVSSLSLASLNTGDNESVHSGKRT 1297
+ K + ++ K++ ++ K ++ I G S S + GKR
Sbjct: 516 EKQQKAKEEMEKKESEQAKKEDKETSAKRGKEITGVKRQSKSEHETSDAKKSVEDRGKRC 575
Query: 1298 PRSE 1301
P E
Sbjct: 576 PTPE 579
>gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 55.5 bits (132), Expect = 4e-07
Identities = 126/573 (21%), Positives = 224/573 (39%), Gaps = 112/573 (19%)
Query: 746 LASEMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGISPLR--- 802
L E +R KLEEK R EAQ+ ++RQ+ GR T+ K + + +
Sbjct: 111 LRYEEAEVRKKLEEKDRQEEAQR------LQQKRQETGREDGGTLAKGSLENVLDSKDKT 164
Query: 803 EEAAGAEDEKVYTDR-----AKEKESQKTDGQRSKSLADIKESMENPQAKWLKSPTTP-- 855
+++ G ++EK T AKE + TD S + D + + + L S + P
Sbjct: 165 QKSNGEKNEKCETKEKGAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEE 224
Query: 856 -IDP--EKQW---NLASPSEETLNEGEILEYTKSIE--------KLNSSLHFLQQEM--- 898
I P W +L S++T + +EY ++ ++ ++L L+ +
Sbjct: 225 AISPGVTASWIEAHLPDDSKDTWKKRGNVEYVVLLDWFSSAKDLQIGTTLRSLKDALFKW 284
Query: 899 -QRLSLQQEMLMQMREQQSWVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTH 957
+ L+ E L+ ++W++ PQ + ++ P +Q S F+ S +
Sbjct: 285 ESKTVLRNEPLVLEGGYENWLLCYPQYTTNAKVTP-PPRRQNEEVSISLDFTYPSLEESI 343
Query: 958 PSPQSSNRKSASFSVKSQRTPRPNELKITPLNRTLTPPRSVDSLPRLRRFSPSQVPIQTR 1017
PS ++ AS V N I+ N + P L +P + ++
Sbjct: 344 PSKPAAQTPPASIEVDE------NIELISGQNERMGP---------LNISTPVEPVAASK 388
Query: 1018 SFVCFGDDGEPQLKESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPV 1077
S V P +K + KK ++ PEE IK EST E S
Sbjct: 389 SDVSPIIQPVPSIKNVPQIDRTKKPAVKL----------PEEHRIKS-ESTNHEQQSPQS 437
Query: 1078 TETVCLTPNEDQLNQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGES 1137
+ + D+ +P VF PT + L+D EKA + E
Sbjct: 438 GKVI-----PDRSTKPV------VFSPT---------LMLTD---EEKARIHAET----- 469
Query: 1138 DKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKK 1197
+ K E ++ ++ +++LR+E++ Q K++ EAE E++
Sbjct: 470 --------------ALLMEKNKQEKELRERQQEEQKEKLRKEEQEQKAKKKQEAE-ENEI 514
Query: 1198 EETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKS 1257
E ++K +EE +KKE E+A++E R K++ T +K + + + KS
Sbjct: 515 TEKQQKAKEEMEKKESEQAKKEDKETSAKRGKEI-------TGVKRQSKSEHETSDAKKS 567
Query: 1258 IHRDHIESPKTPIKGPPVSSLSLASLNTGDNES 1290
+ P I+ + S+ TGD+ S
Sbjct: 568 VEDRGKRCPTPEIQKKSTGDVPHTSV-TGDSGS 599
Score = 32.0 bits (71), Expect = 4.5
Identities = 27/124 (21%), Positives = 55/124 (44%), Gaps = 6/124 (4%)
Query: 1182 TQLRKQQLEAE----MEHKKEETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDM 1237
T K ++ AE ME K+E ++ E +Q+++ E+ R+E Q+ ++++ + E
Sbjct: 458 TDEEKARIHAETALLMEKNKQE--KELRERQQEEQKEKLRKEEQEQKAKKKQEAEENEIT 515
Query: 1238 DTVIKPRPQVVKQKKQRPKSIHRDHIESPKTPIKGPPVSSLSLASLNTGDNESVHSGKRT 1297
+ K + ++ K++ ++ K ++ I G S S + GKR
Sbjct: 516 EKQQKAKEEMEKKESEQAKKEDKETSAKRGKEITGVKRQSKSEHETSDAKKSVEDRGKRC 575
Query: 1298 PRSE 1301
P E
Sbjct: 576 PTPE 579
>gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 55.5 bits (132), Expect = 4e-07
Identities = 126/573 (21%), Positives = 224/573 (39%), Gaps = 112/573 (19%)
Query: 746 LASEMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGISPLR--- 802
L E +R KLEEK R EAQ+ ++RQ+ GR T+ K + + +
Sbjct: 111 LRYEEAEVRKKLEEKDRQEEAQR------LQQKRQETGREDGGTLAKGSLENVLDSKDKT 164
Query: 803 EEAAGAEDEKVYTDR-----AKEKESQKTDGQRSKSLADIKESMENPQAKWLKSPTTP-- 855
+++ G ++EK T AKE + TD S + D + + + L S + P
Sbjct: 165 QKSNGEKNEKCETKEKGAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEE 224
Query: 856 -IDP--EKQW---NLASPSEETLNEGEILEYTKSIE--------KLNSSLHFLQQEM--- 898
I P W +L S++T + +EY ++ ++ ++L L+ +
Sbjct: 225 AISPGVTASWIEAHLPDDSKDTWKKRGNVEYVVLLDWFSSAKDLQIGTTLRSLKDALFKW 284
Query: 899 -QRLSLQQEMLMQMREQQSWVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTH 957
+ L+ E L+ ++W++ PQ + ++ P +Q S F+ S +
Sbjct: 285 ESKTVLRNEPLVLEGGYENWLLCYPQYTTNAKVTP-PPRRQNEEVSISLDFTYPSLEESI 343
Query: 958 PSPQSSNRKSASFSVKSQRTPRPNELKITPLNRTLTPPRSVDSLPRLRRFSPSQVPIQTR 1017
PS ++ AS V N I+ N + P L +P + ++
Sbjct: 344 PSKPAAQTPPASIEVDE------NIELISGQNERMGP---------LNISTPVEPVAASK 388
Query: 1018 SFVCFGDDGEPQLKESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPV 1077
S V P +K + KK ++ PEE IK EST E S
Sbjct: 389 SDVSPIIQPVPSIKNVPQIDRTKKPAVKL----------PEEHRIKS-ESTNHEQQSPQS 437
Query: 1078 TETVCLTPNEDQLNQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGES 1137
+ + D+ +P VF PT + L+D EKA + E
Sbjct: 438 GKVI-----PDRSTKPV------VFSPT---------LMLTD---EEKARIHAET----- 469
Query: 1138 DKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKK 1197
+ K E ++ ++ +++LR+E++ Q K++ EAE E++
Sbjct: 470 --------------ALLMEKNKQEKELRERQQEEQKEKLRKEEQEQKAKKKQEAE-ENEI 514
Query: 1198 EETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKS 1257
E ++K +EE +KKE E+A++E R K++ T +K + + + KS
Sbjct: 515 TEKQQKAKEEMEKKESEQAKKEDKETSAKRGKEI-------TGVKRQSKSEHETSDAKKS 567
Query: 1258 IHRDHIESPKTPIKGPPVSSLSLASLNTGDNES 1290
+ P I+ + S+ TGD+ S
Sbjct: 568 VEDRGKRCPTPEIQKKSTGDVPHTSV-TGDSGS 599
Score = 32.0 bits (71), Expect = 4.5
Identities = 27/124 (21%), Positives = 55/124 (44%), Gaps = 6/124 (4%)
Query: 1182 TQLRKQQLEAE----MEHKKEETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDM 1237
T K ++ AE ME K+E ++ E +Q+++ E+ R+E Q+ ++++ + E
Sbjct: 458 TDEEKARIHAETALLMEKNKQE--KELRERQQEEQKEKLRKEEQEQKAKKKQEAEENEIT 515
Query: 1238 DTVIKPRPQVVKQKKQRPKSIHRDHIESPKTPIKGPPVSSLSLASLNTGDNESVHSGKRT 1297
+ K + ++ K++ ++ K ++ I G S S + GKR
Sbjct: 516 EKQQKAKEEMEKKESEQAKKEDKETSAKRGKEITGVKRQSKSEHETSDAKKSVEDRGKRC 575
Query: 1298 PRSE 1301
P E
Sbjct: 576 PTPE 579
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 53.9 bits (128), Expect = 1e-06
Identities = 86/376 (22%), Positives = 141/376 (37%), Gaps = 53/376 (14%)
Query: 758 EEKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGISPLREEAAGAEDEKVYTDR 817
E+K A+ A+K ++ + K V +KK + P + EA A+ +V +
Sbjct: 10703 EKKAPAVVAKKPELPPVKVPEVPKE------VVPEKKVPLVVPKKPEAPPAKVPEVPKEV 10756
Query: 818 AKEKESQKTDGQRSKSLADIKESMENPQAKWLKSPTTPIDPEKQW-----NLASPSEETL 872
EK+ + + E P AK + P P+ EK SP E
Sbjct: 10757 VPEKK------------VAVPKKPEVPPAKVPEVPKKPVLEEKPAVPVPERAESPPPEVY 10804
Query: 873 NEGEILEYTKSI----EKLNSSLHFLQQEMQRLSLQQEMLMQMREQQSWVISPPQPSPQK 928
E E + + I EK + E+ ++ +E + E++ VI P+ P K
Sbjct: 10805 EEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPK 10864
Query: 929 QIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSPQSSNRKSASFSVKSQRTPRPNELKITPL 988
+ K ++ P P P P+P + K F +K+ + E P
Sbjct: 10865 EPEPEKVIEK--------PKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVPE 10916
Query: 989 NRTLTPPRSVDSLPRLRRFSPSQVPIQTRSFVCFGDDGEPQLKESKPKEEVKKEELESKG 1048
LTP + ++R+ P + P + + V + +E +PK E KK E K
Sbjct: 10917 KVELTPLKVPGGEKKVRKLLPERKP-EPKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKKP 10975
Query: 1049 TLEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLTPNEDQLNQPTEPPP-KPVFPPTAP 1107
+ PE KP E E +T E ++ +PT+ P KP P AP
Sbjct: 10976 AV------PEPPPPKPVEE----------VEVPTVTKRERKIPEPTKVPEIKPAIPLPAP 11019
Query: 1108 KNVNLIEVSLSDLKPP 1123
+ E + +KPP
Sbjct: 11020 EPKPKPEAEVKTIKPP 11035
Score = 52.0 bits (123), Expect = 4e-06
Identities = 112/507 (22%), Positives = 189/507 (37%), Gaps = 110/507 (21%)
Query: 818 AKEKESQKTDGQRSKSLADIKESMENPQAKWLKSPTTPIDPEKQWNLASPSEETLNEGEI 877
AK E K K + + +E P AK + P P+ PEK+ + +P + ++
Sbjct: 10002 AKVPEVPKKPVPEEKVPVPVPKKVEAPPAKVPEVPKKPV-PEKKVPVPAPKKVEAPPAKV 10060
Query: 878 LEYTKSIEKLNSSLHFLQQEMQRLSLQQEMLMQMREQQSWVISPPQPSPQKQ----IRDF 933
E K + + +E + + ++ V +PP P+K+ +
Sbjct: 10061 PEVPKKL---------IPEEKKPTPVPKK-----------VEAPPPKVPKKREPVPVPVA 10100
Query: 934 KPSKQAGL-SSAIAPFSSDSPRPTHPSPQSSNRKSASFSVKSQRTPRPNELKITPLNRTL 992
P ++ L I P P P+ + + P E +I P +
Sbjct: 10101 LPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEE------VLPEEEEVLPEEEEIPPEEEEV 10154
Query: 993 TPPRSVDSLPRLRRFSPSQVPIQTRSFVCFGDDGEPQLKESKPKEEVKKEELESKGTLEQ 1052
P + +P F P + + + +P++ P E+KK+ E K + +
Sbjct: 10155 PPEE--EYVPEEEEFVPEEEVLP---------EVKPKVPVPAPVPEIKKKVTEKKVVIPK 10203
Query: 1053 RGHNP------------EEKEIKPFESTVSEVLSLPVTETVCLTPNEDQLNQ---PTEPP 1097
+ P E++ I P E EVL + VTE P E+ +++ P EPP
Sbjct: 10204 KEEAPPAKVPEVPKKVEEKRIILPKEE---EVLPVEVTEE----PEEEPISEEEIPEEPP 10256
Query: 1098 ----------PK---------PVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGESD 1138
P+ P P PK V +S P EK VPV+K +
Sbjct: 10257 SIEEVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAPPAKVSKKIPEEKVPVPVQKKEAPPA 10316
Query: 1139 K----EQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEK---RLRRE--KETQLRKQQL 1189
K + ++KV +K A R L EK R+E + +L + +
Sbjct: 10317 KVPEVPKKVPEKKVLV------PKKEAVPPAKGRTVLEEKVSVAFRQEVVVKERLELEVV 10370
Query: 1190 EAEMEHKKEETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVK 1249
EAE+E EE EE ++ + EFI+ E R ++ +E + VI +V +
Sbjct: 10371 EAEVEEIPEEEEFHEVEEYFEEGEFHEVEEFIKLEQHRVEEEHRVEKVHRVI----EVFE 10426
Query: 1250 QKKQRPKSIHRDHIESPKTPIKGPPVS 1276
++ + E PK P KGP +S
Sbjct: 10427 AEEV-------EVFEKPKAPPKGPEIS 10446
Score = 36.6 bits (83), Expect = 0.18
Identities = 97/467 (20%), Positives = 175/467 (37%), Gaps = 54/467 (11%)
Query: 842 ENPQAKWLKSPTTP--IDPEKQWNLASPSEETLNEGEILEYTKSI---EKLNSSLHFLQQ 896
+ P+ +K P P + PEK+ + P + + ++ E K +K+ ++ +
Sbjct: 10600 KKPEVTPVKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPE 10659
Query: 897 EMQRLSLQQEMLMQMREQQSWVISPPQPSPQKQI----RDFKPSKQAGLSSAIAPFSSDS 952
++ + + E + V+ P+P+ Q+ + P K+A A P
Sbjct: 10660 SPPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPV 10719
Query: 953 PRPTHPSPQSSNRKSASFSVKSQRTPRPNELKITPLNRTLTPPRSVDSLPRLRRFSPSQV 1012
P P +K K P K+ + + + P + V ++P+ P++V
Sbjct: 10720 KVPEVPKEVVPEKKVPLVVPKKPEAP---PAKVPEVPKEVVPEKKV-AVPKKPEVPPAKV 10775
Query: 1013 P-------IQTRSFVCFGDDGE---PQL----KESKPKEEVKKEELESKGTLEQRGHN-- 1056
P ++ + V + E P++ +E P+EE+ EE + E+
Sbjct: 10776 PEVPKKPVLEEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVP 10835
Query: 1057 ----PEE-KEIKPFEST--VSEVLSLPVTETVCLTPNEDQLNQPTEPPPKPVFPPTAPKN 1109
PEE K+I P + + + + P E E +P PPP P P K
Sbjct: 10836 PPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDVKE 10895
Query: 1110 VNLIEVSLSDLKPPEKADVPVEKYDGESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRA 1169
++ K PEK VP EK + K ++KV E K
Sbjct: 10896 KIFQLKAIPKKKVPEKPQVP-EKVELTPLKVP-GGEKKV-------RKLLPERKPEPKEE 10946
Query: 1170 ALLEKRLRREKETQLRKQQLEAEMEHKKEETRRK---TEEERQKKEDERARREFIRQEYM 1226
+L+ LR+ R ++ E ++E KK E +K E K +E ++E
Sbjct: 10947 VVLKSVLRK------RPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRERK 11000
Query: 1227 RRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHIESPKTPIKGP 1273
+ K+ E + P P+ + + K+I +E TPI P
Sbjct: 11001 IPEPTKVPEIKPAIPLPAPEPKPKPEAEVKTIKPPPVEPEPTPIAAP 11047
Score = 36.2 bits (82), Expect = 0.24
Identities = 98/509 (19%), Positives = 180/509 (35%), Gaps = 67/509 (13%)
Query: 809 EDEKVYTDRAK---EKESQKTDGQRSKSLADIKESMENPQAKWLKSPTTPIDPEKQWNLA 865
E E+ Y +R +KE + +R K A + E P K +K P + +
Sbjct: 9139 EWEEAYQEREVIQVQKEVYEESHER-KVPAKVPEKKAPPPPKVIKKPVIEKIEKTSRRM- 9196
Query: 866 SPSEETLNEGEILEYTKSIEKLNSSLHFLQQEMQRLSL-----------QQEMLMQMREQ 914
EE + ++ E +K I S +Q+E+ + + +++M +
Sbjct: 9197 --EEEKVQVTKVPEVSKKIVPQKPSRTPVQEEVIEVKVPAVHTKKMVISEEKMFFASHTE 9254
Query: 915 QSWVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSS-----DSPRPTHPSPQSSNRKSAS 969
+ +S P QK+I + +S + P + P P +P +K
Sbjct: 9255 EE--VSVTVPEVQKEIVT-EEKIHVAISKRVEPPPKVPELPEKPAPEEVAPVPIPKKVEP 9311
Query: 970 FSVKSQRTPR---PNELKITPL-NRTLTPPRSVDSLPRL--------------RRFSPSQ 1011
+ K P+ P E K P+ + P V +P+ + P++
Sbjct: 9312 PAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVAKKKEAPPAK 9371
Query: 1012 VPIQTRSFVCFGDDGEPQLKESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTVSE 1071
VP + V +E P V E+ K E+R P ++E P V
Sbjct: 9372 VPEVQKGVVTEEKITIVTQREESPPPAVP--EIPKKKVPEERKPVPRKEEEVPPPPKVPA 9429
Query: 1072 VLSLPVTETVCLTPNEDQLNQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPVE 1131
+ PV E P P PP V T + + P++ +V
Sbjct: 9430 LPKKPVPEEKVAVPVPVAKKAP--PPRAEVSKKTVVEEKRFVAEEKLSFAVPQRVEVTRH 9487
Query: 1132 KYDGESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEA 1191
+ E + ++++ V + +++++ E + A + E + E E + +++L
Sbjct: 9488 EVSAEEEWSYSEEEEGVSISVYREEEREEEEE-----AEVTEYEVMEEPEEYVVEEKLHI 9542
Query: 1192 EMEHKKEETRRKTEEERQK---KEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVV 1248
+ + E TE + +K K A+ E + K++ + P P
Sbjct: 9543 ISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVPEKKV---PAPVPK 9599
Query: 1249 KQKKQRPKSIHRDHIESPKTPI---KGPP 1274
K+K PK E PK P+ K PP
Sbjct: 9600 KEKVPPPKV-----PEEPKKPVPEKKVPP 9623
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 53.1 bits (126), Expect = 2e-06
Identities = 50/219 (22%), Positives = 93/219 (42%), Gaps = 30/219 (13%)
Query: 1157 DQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKKEDERA 1216
+Q+ E ++ E+ RR++E + R+++ E + ++ E RRK EEER++ E+E+
Sbjct: 400 EQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKR 459
Query: 1217 RREFIRQEYMRRK-----------QLKLMEDMDTVI----KPRPQVVKQKKQRPKSIHRD 1261
R E QEY+RR+ Q +L+++ ++ +P PQ +Q + +
Sbjct: 460 RVE-REQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKP 518
Query: 1262 HIESPKTPIKGPPVSSLSLASLNTGDNESVHSGKRTPRSESVEGFLSPSRCGSRNGEKD- 1320
+P+ P + T V S + +P S + S+ G RN
Sbjct: 519 SFHAPEPKAHYEPADRAREVPVRTTSRSPVLSRRDSPLQGSGQ---QNSQAGQRNSTSSI 575
Query: 1321 -----WENASTT-----SSVASGTEYTGPKLYKEPSAKS 1349
WE S +SG+ +G + P ++S
Sbjct: 576 EPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQS 614
Score = 40.8 bits (94), Expect = 0.010
Identities = 26/118 (22%), Positives = 60/118 (50%), Gaps = 5/118 (4%)
Query: 1152 FFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKK 1211
F + E A++R LL+++ RE+E R+ E + ++++ +R+ EE+Q++
Sbjct: 356 FLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRR 415
Query: 1212 EDERARREFIRQEYMRRKQLKLMEDMDTVIKP-----RPQVVKQKKQRPKSIHRDHIE 1264
E E R++ Q +++ + +E+++ K R + K++ +R + R +E
Sbjct: 416 EREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLE 473
Score = 35.0 bits (79), Expect = 0.54
Identities = 37/165 (22%), Positives = 71/165 (43%), Gaps = 15/165 (9%)
Query: 1082 CLTPNEDQLNQPTEPPPKPVFPPTAPKNVNLIEVSLSD------LKPPEKADVPVEKYDG 1135
CL N Q TE K F P N + + L D K EK + E
Sbjct: 269 CLVKNYMQ-RPSTEQLLKHPFIRDQP-NERQVRIQLKDHIDRTRKKRGEKDETEYEYSGS 326
Query: 1136 ESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEME- 1194
E ++E+ + + + ++R L ++ +E+ LR+QQL E +
Sbjct: 327 EEEEEEVPEQEGEPSSIV-----NVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQL 381
Query: 1195 HKKEETRRKTEEERQKK-EDERARREFIRQEYMRRKQLKLMEDMD 1238
++EE +R+ ERQK+ E ++ +R + ++ R ++ + ++ +
Sbjct: 382 REQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQERE 426
Score = 33.1 bits (74), Expect = 2.0
Identities = 31/130 (23%), Positives = 60/130 (46%), Gaps = 8/130 (6%)
Query: 744 QLLASEMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGISPLR- 802
QLLA + + E++RR E Q+++ EA ++R++ R K++ + + R
Sbjct: 390 QLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRRE---QEEKRRLEELERRRK 446
Query: 803 --EEAAGAEDEKVYTDRAKEKESQKTDGQRSKSLADIKESMENPQAKWLKSPTTPIDPEK 860
EE AE+EK +R +E ++ + + + L +++ + QA L P P+
Sbjct: 447 EEEERRRAEEEKRRVEREQEYIRRQLE-EEQRHLEVLQQQLLQEQAMLLHDHRRP-HPQH 504
Query: 861 QWNLASPSEE 870
P +E
Sbjct: 505 SQQPPPPQQE 514
>gi|4505101 microtubule-associated protein 7 [Homo sapiens]
Length = 749
Score = 53.1 bits (126), Expect = 2e-06
Identities = 133/660 (20%), Positives = 254/660 (38%), Gaps = 96/660 (14%)
Query: 696 KLNHTDGKSSGSSSQKTTPEGSELNIPHVVAWAQIPEETGLPQGRDTT---QLLASEMVH 752
K N + +S S Q G++ + P V+ ++ + L + R QL A E+V
Sbjct: 32 KKNASSRPASAISGQNNNHSGNKPDPPPVL---RVDDRQRLARERREEREKQLAAREIVW 88
Query: 753 LRMKLEEKR---RAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGISPLREEAAGAE 809
L + ++ + +E +KK++E +QRQK R K++ A
Sbjct: 89 LEREERARQHYEKHLEERKKRLE----EQRQKEERRRAAVEEKRRQRLEEDKERHEAVVR 144
Query: 810 DEKVYTDRAKEKESQKTDGQRSKSLADIKESMENPQAKWLKSPTTPIDPEKQWNLASPSE 869
+ + K+K ++ + G I + + ++ + + +DP L+S S
Sbjct: 145 RTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSA 204
Query: 870 ETLNEGEILEY-------TKSIEKLNSSLH-FLQQEMQRLSLQQE------MLMQMREQQ 915
LN + + + +L + H FL + +L E ++M +
Sbjct: 205 TLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLARSKSTAALSGEAASCSPIIMPYKAAH 264
Query: 916 S--------WVISPPQPSPQKQIRDFKPS-KQAGLSSAIAPFSSDSPRPTHPS-PQSSNR 965
S ++PP+ S +++I S K+ + +S + R PS P++
Sbjct: 265 SRNSMDRPKLFVTPPEGSSRRRIIHGTASYKKERERENVLFLTSGTRRAVSPSNPKARQP 324
Query: 966 KSASFSVKSQRTPRPNELKITPLNRTLTPPRSVDSLP-RLRRFSPSQVPIQTRSFVCFGD 1024
+ + S+ P L TP + PP SV + P ++R SP + R +
Sbjct: 325 ARSRLWLPSKSLPH---LPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVEPE 381
Query: 1025 DGEPQLKESKPKEE---------VKKEELESKGTLEQRGHNPEEKEIKPFESTVSEVLSL 1075
+P+ + K E VK EE T+E+R P E E+ P ++ +
Sbjct: 382 KKDPEKEPQKVANEPSLKGRAPLVKVEE----ATVEER--TPAEPEVGPAAPAMAPAPAS 435
Query: 1076 PVTETVCLTPNEDQLNQPTEPPPKPVFPPTAPKNVNL-IEVSLSDLKPPEKADVPVEKYD 1134
P P P V P++ N + ++ S P E + EK
Sbjct: 436 APAPASAPAP-------APVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKR- 487
Query: 1135 GESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQ--QLEAE 1192
+EQ + +++ +++ + ++ ++ L +R+ E+ T+ ++ +LEAE
Sbjct: 488 -RLAREQREKEER---------ERREQEELERQKREELAQRVAEERTTRREEESRRLEAE 537
Query: 1193 MEHKKEETRRKTEEER-------------QKKEDERARREFIRQEYMRRKQLKLMEDMDT 1239
+KEE ++ EER QK+E+ R R E R R K + E
Sbjct: 538 QAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERL 597
Query: 1240 VIKPRPQVVKQKKQRPKSIHRDHIESPKTPIK------GPPVSSLSLASLNTGDNESVHS 1293
K R + + ++ +R ++ + + I G VS+L + G+ + V S
Sbjct: 598 ERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKPVGS 657
Score = 37.4 bits (85), Expect = 0.11
Identities = 60/310 (19%), Positives = 120/310 (38%), Gaps = 48/310 (15%)
Query: 724 VVAWAQIPEETGLPQGRDTTQLLASEMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQKMG 783
V A A + G + T+LLA EKRR Q++K E ++++++
Sbjct: 461 VNASASVKTSAGTTDPEEATRLLA-----------EKRRLAREQREKEERE-RREQEELE 508
Query: 784 RTAFLTVVKKKGDGISPLREEAAGAEDEKVYTDRAKEKESQKTDGQRSKSLADIKESMEN 843
R + ++ + + REE E ++ ++A+EKE Q ++L + +E+
Sbjct: 509 RQKREELAQRVAEERTTRREE----ESRRLEAEQAREKEEQLQRQAEERALREREEAERA 564
Query: 844 PQAKWLKSPTTPIDPEKQWNLASPSEETLNEGEILEYTKSIEKLNSSLHFLQQEMQRLSL 903
+ K E++ + +E E E HF ++E +RL
Sbjct: 565 QRQK-----------EEEARVREEAERVRQERE--------------KHFQREEQERLER 599
Query: 904 QQEMLMQMREQQSWVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHP--SPQ 961
++ + M+ + + + S Q+ K + G + P ++++P P SP
Sbjct: 600 KKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKPVGSPH 659
Query: 962 SSNRKSASFSVKS----QRTPRPNELKITPLNRTLTPPRSVDSLPRLRRFSPSQVP-IQT 1016
+ +V+S ++ P N + + N + S P + S+ P I
Sbjct: 660 VVTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEIINLPIGSKPSRLDVTNSESPEIPL 719
Query: 1017 RSFVCFGDDG 1026
+ F D+G
Sbjct: 720 NPILAFDDEG 729
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 [Homo
sapiens]
Length = 916
Score = 52.4 bits (124), Expect = 3e-06
Identities = 59/244 (24%), Positives = 115/244 (47%), Gaps = 32/244 (13%)
Query: 1031 KESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLTPNEDQL 1090
K KPK E K +++ K E EE +++ +S + E L+ +TE + ++ E++
Sbjct: 435 KIQKPKVEAPKLKVQHKFVEEII----EETKVEDEKSEMEEALTA-ITEELAVSMKEEKK 489
Query: 1091 NQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVP-VEKYDGESDKEQFDDDQKVC 1149
E +P E ++ K P KA P V++ +GE ++E+ ++++
Sbjct: 490 EAAEEKEEEP----------EAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEE-- 537
Query: 1150 CGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQ 1209
++D+ A++D A + + EK EKE + +++ E E E + EE K E
Sbjct: 538 -----EEDEGAKSDQAEEGGS--EKEGSSEKE-EGEQEEGETEAEAEGEEAEAKEE---- 585
Query: 1210 KKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHIES--PK 1267
KK +E++ ++E + +++ E + + P K K PKS + +S PK
Sbjct: 586 KKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPK 645
Query: 1268 TPIK 1271
+P++
Sbjct: 646 SPVE 649
Score = 40.4 bits (93), Expect = 0.013
Identities = 60/251 (23%), Positives = 102/251 (40%), Gaps = 33/251 (13%)
Query: 1027 EPQLKESKPKEEVKKEELESKGTL--EQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLT 1084
E + KE K EE K EE+ +K L + + PE+ + +S V E PV ++
Sbjct: 579 EAEAKEEKKVEE-KSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEE 637
Query: 1085 PNEDQL-NQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGESDKEQFD 1143
+ + P E K P + + VS S ++ EKA PV K E K + +
Sbjct: 638 KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVE--EKAKSPVPKSPVEEAKSKAE 695
Query: 1144 DDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKE----- 1198
K +QK E + +K A EK ++E++ + ++ +AE K+E
Sbjct: 696 VG---------KGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEV 746
Query: 1199 -------------ETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRP 1245
ET+ + + +Q+KE E+A E +E K K D +
Sbjct: 747 VTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEV 806
Query: 1246 QVVKQKKQRPK 1256
+ ++ +Q K
Sbjct: 807 EGKEEVEQETK 817
Score = 37.7 bits (86), Expect = 0.083
Identities = 62/339 (18%), Positives = 146/339 (43%), Gaps = 38/339 (11%)
Query: 764 IEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGISPLREEAAGAEDEKVYTDRAKEK-- 821
+E +K +ME A T +++ + +K++ + +EE AE+E+V ++ K
Sbjct: 462 VEDEKSEMEEALTAITEELAVS-----MKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKAT 516
Query: 822 --ESQKTDGQRSKSLADIKESMENPQAKWLKSPTTPIDPEKQWNLASPSEETLNEGEILE 879
E ++ +G++ + +E E+ AK S ++ + E EGE
Sbjct: 517 APEVKEEEGEKEEEEGQEEEEEEDEGAK---SDQAEEGGSEKEGSSEKEEGEQEEGETEA 573
Query: 880 YTKSIEKLNSSLHFLQQEMQRLSLQQEMLMQMREQQSWVISPPQPSPQKQIRDFKPSKQA 939
+ E ++++ + ++ ++E++ + ++ P P + + P ++
Sbjct: 574 EAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKS 633
Query: 940 GLSSAIAPFSSDSPRPTHPSPQSSNRKSASFSVKSQRTPRPNELKITPLNRTLTPPRSVD 999
P P SP KS ++P + K +P++++ ++
Sbjct: 634 -------PVEEKGKSPVPKSPVEEKGKSPV-----PKSPVEEKGK-SPVSKSPVEEKAKS 680
Query: 1000 SLPRLRRFSPSQVPIQTRSFVCFGD---DGEPQLKESKPKEEVKKEELESKGTLEQRGHN 1056
+P+ SP + ++++ V G+ + E ++KE+ +E+V+K+E + K E++
Sbjct: 681 PVPK----SPVE-EAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKK--- 732
Query: 1057 PEEKEIKPFESTVSEVLSLPVTETVCLTPNEDQLNQPTE 1095
E +K E V+EV+++ + V L + +P +
Sbjct: 733 KAESPVK--EEAVAEVVTITKSVKVHLEKETKEEGKPLQ 769
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 [Homo
sapiens]
Length = 540
Score = 52.4 bits (124), Expect = 3e-06
Identities = 59/244 (24%), Positives = 115/244 (47%), Gaps = 32/244 (13%)
Query: 1031 KESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLTPNEDQL 1090
K KPK E K +++ K E EE +++ +S + E L+ +TE + ++ E++
Sbjct: 59 KIQKPKVEAPKLKVQHKFVEEII----EETKVEDEKSEMEEALTA-ITEELAVSMKEEKK 113
Query: 1091 NQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVP-VEKYDGESDKEQFDDDQKVC 1149
E +P E ++ K P KA P V++ +GE ++E+ ++++
Sbjct: 114 EAAEEKEEEP----------EAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEE-- 161
Query: 1150 CGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQ 1209
++D+ A++D A + + EK EKE + +++ E E E + EE K E
Sbjct: 162 -----EEDEGAKSDQAEEGGS--EKEGSSEKE-EGEQEEGETEAEAEGEEAEAKEE---- 209
Query: 1210 KKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHIES--PK 1267
KK +E++ ++E + +++ E + + P K K PKS + +S PK
Sbjct: 210 KKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPK 269
Query: 1268 TPIK 1271
+P++
Sbjct: 270 SPVE 273
Score = 40.4 bits (93), Expect = 0.013
Identities = 60/251 (23%), Positives = 102/251 (40%), Gaps = 33/251 (13%)
Query: 1027 EPQLKESKPKEEVKKEELESKGTL--EQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLT 1084
E + KE K EE K EE+ +K L + + PE+ + +S V E PV ++
Sbjct: 203 EAEAKEEKKVEE-KSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEE 261
Query: 1085 PNEDQL-NQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGESDKEQFD 1143
+ + P E K P + + VS S ++ EKA PV K E K + +
Sbjct: 262 KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVE--EKAKSPVPKSPVEEAKSKAE 319
Query: 1144 DDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKE----- 1198
K +QK E + +K A EK ++E++ + ++ +AE K+E
Sbjct: 320 VG---------KGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEV 370
Query: 1199 -------------ETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRP 1245
ET+ + + +Q+KE E+A E +E K K D +
Sbjct: 371 VTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEV 430
Query: 1246 QVVKQKKQRPK 1256
+ ++ +Q K
Sbjct: 431 EGKEEVEQETK 441
Score = 37.7 bits (86), Expect = 0.083
Identities = 62/339 (18%), Positives = 146/339 (43%), Gaps = 38/339 (11%)
Query: 764 IEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGISPLREEAAGAEDEKVYTDRAKEK-- 821
+E +K +ME A T +++ + +K++ + +EE AE+E+V ++ K
Sbjct: 86 VEDEKSEMEEALTAITEELAVS-----MKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKAT 140
Query: 822 --ESQKTDGQRSKSLADIKESMENPQAKWLKSPTTPIDPEKQWNLASPSEETLNEGEILE 879
E ++ +G++ + +E E+ AK S ++ + E EGE
Sbjct: 141 APEVKEEEGEKEEEEGQEEEEEEDEGAK---SDQAEEGGSEKEGSSEKEEGEQEEGETEA 197
Query: 880 YTKSIEKLNSSLHFLQQEMQRLSLQQEMLMQMREQQSWVISPPQPSPQKQIRDFKPSKQA 939
+ E ++++ + ++ ++E++ + ++ P P + + P ++
Sbjct: 198 EAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKS 257
Query: 940 GLSSAIAPFSSDSPRPTHPSPQSSNRKSASFSVKSQRTPRPNELKITPLNRTLTPPRSVD 999
P P SP KS ++P + K +P++++ ++
Sbjct: 258 -------PVEEKGKSPVPKSPVEEKGKSPV-----PKSPVEEKGK-SPVSKSPVEEKAKS 304
Query: 1000 SLPRLRRFSPSQVPIQTRSFVCFGD---DGEPQLKESKPKEEVKKEELESKGTLEQRGHN 1056
+P+ SP + ++++ V G+ + E ++KE+ +E+V+K+E + K E++
Sbjct: 305 PVPK----SPVE-EAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKK--- 356
Query: 1057 PEEKEIKPFESTVSEVLSLPVTETVCLTPNEDQLNQPTE 1095
E +K E V+EV+++ + V L + +P +
Sbjct: 357 KAESPVK--EEAVAEVVTITKSVKVHLEKETKEEGKPLQ 393
>gi|51873049 hypothetical protein LOC8603 [Homo sapiens]
Length = 1224
Score = 52.4 bits (124), Expect = 3e-06
Identities = 52/213 (24%), Positives = 97/213 (45%), Gaps = 30/213 (14%)
Query: 1103 PPTAPKNVNLIEVSLS-DLKPPEKADVPVEKYDGESDKEQFDDDQKV--CCGFFFKDDQK 1159
PP AP + N E+ L+ ++ + +K D S++E D ++V F + K
Sbjct: 802 PPAAPTSRNYAEMREKLRLRLTKRKEEQPKKMDQISERESVVDHRRVEDLLQFINSSETK 861
Query: 1160 -AENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKKEDERARR 1218
+ A KRA +++L E++ +L + E H +EE RR+ EEE +++E++R +
Sbjct: 862 PVSSTRAAKRARHKQRKL--EEKARLEAEARAREHLHLQEEQRRREEEEDEEEEEDRFKE 919
Query: 1219 EFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHIESPKTPIKGPPVSSL 1278
EF R + +++ + V K+KK+RP + PK + +
Sbjct: 920 EFQRLQELQKLR---------------AVKKKKKERPSK------DCPKLDML---TRNF 955
Query: 1279 SLASLNTGDNESVHSGKRTPRSESVEGFLSPSR 1311
A+ + ++ ++H+G E SPSR
Sbjct: 956 QAATESVPNSGNIHNGSLEQTEEPETSSHSPSR 988
>gi|15826852 acyl-Coenzyme A binding domain containing 3 [Homo
sapiens]
Length = 528
Score = 52.4 bits (124), Expect = 3e-06
Identities = 54/224 (24%), Positives = 92/224 (41%), Gaps = 20/224 (8%)
Query: 1149 CCGFF--FKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEE 1206
CC F + K E + K+ E+R RRE+E + R Q+ E + ++EE R+ EE
Sbjct: 168 CCHLFSTYVASHKIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEE 227
Query: 1207 ERQKKEDERARREFIRQEYMRR-KQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHIES 1265
ER++ E+ER R E +Q+ M ++ + P +Q++ + + H +
Sbjct: 228 ERRRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQ 287
Query: 1266 PKTPIKGPPVSSLSLASLNTGDNESVHSGKRTPRSESVEGFLSPSRCGSRNG-------- 1317
+ ++ A E V +G P S V + PS S NG
Sbjct: 288 YMQQLYQVQLAQQQAALQK--QQEVVVAGSSLPTSSKVNATV-PSNMMSVNGQAKTHTDS 344
Query: 1318 -EKDWENASTTSSVASGTE-----YTGPKLYKEPSAKSNKHIIQ 1355
EK+ E + ++ +G + P ++ P K K IQ
Sbjct: 345 SEKELEPEAAEEALENGPKESLPVIAAPSMWTRPQIKDFKEKIQ 388
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 52.0 bits (123), Expect = 4e-06
Identities = 32/102 (31%), Positives = 54/102 (52%), Gaps = 4/102 (3%)
Query: 1172 LEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKKEDERARREFIRQEYMRRKQL 1231
LE++ RREKE LRKQQ + H +E+ RR+ E R + E E R++ Q R Q
Sbjct: 405 LEEQQRREKE--LRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQR 462
Query: 1232 KLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHIESPKTPIKGP 1273
+L ++ D ++ + Q +Q+ K ++ H + +P + P
Sbjct: 463 QLKQERDYLVSLQHQRQEQRPVEKKPLY--HYKEGMSPSEKP 502
Score = 45.8 bits (107), Expect = 3e-04
Identities = 34/125 (27%), Positives = 66/125 (52%), Gaps = 14/125 (11%)
Query: 1156 DDQKAENDMAMKRAALLEKRLRREKETQLRK-----QQLEAEMEHKKEETRRKTEEERQK 1210
+ Q+ EN+ KR L E++ R E++ + R+ Q+ E E+ ++E +R+ EE+ +
Sbjct: 374 EQQQRENE-EHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMR 432
Query: 1211 KEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHIESPKTPI 1270
+E+ER R E QEY +RKQL+ + + + + K++R + H + P+
Sbjct: 433 REEERRRAEH-EQEY-KRKQLEEQRQAERLQR------QLKQERDYLVSLQHQRQEQRPV 484
Query: 1271 KGPPV 1275
+ P+
Sbjct: 485 EKKPL 489
Score = 44.7 bits (104), Expect = 7e-04
Identities = 38/179 (21%), Positives = 76/179 (42%), Gaps = 15/179 (8%)
Query: 1082 CLTPNEDQLNQPTEPPPKPVFPPTAPKNVNLIEVSLSD------LKPPEKADVPVEKYDG 1135
CL N Q TE K F P N + + L D K EK + E
Sbjct: 269 CLVKNHSQ-RPATEQLMKHPFIRDQP-NERQVRIQLKDHIDRTKKKRGEKDETEYEYSGS 326
Query: 1136 ESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEH 1195
E ++E+ D + + ++R L + +E+ LR+QQLE +
Sbjct: 327 EEEEEENDSGEP-------SSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRE 379
Query: 1196 KKEETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQR 1254
+E R+ E +++ E+++ +R + ++ R K+L+ ++ + Q+ +++++R
Sbjct: 380 NEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERR 438
Score = 36.6 bits (83), Expect = 0.18
Identities = 64/282 (22%), Positives = 113/282 (40%), Gaps = 38/282 (13%)
Query: 744 QLLASEMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGISPLRE 803
QLLA + + E++RR E Q+++ E KQ+++ R + ++++ E
Sbjct: 386 QLLAERQKRIEEQKEQRRRLEEQQRREKE--LRKQQEREQRRHYEEQMRRE--------E 435
Query: 804 EAAGAEDEKVYTDRAKEKESQKTDGQRS-KSLADIKESMENPQAKWLKSPTTPIDPEKQW 862
E AE E+ Y + E++ Q QR K D S+++ + + P+ K+
Sbjct: 436 ERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEG 495
Query: 863 NLASPSEE------------TLNEGEILEYTKSI-EKLNSSLHFLQQEMQRLSLQQEMLM 909
SPSE+ ++G L ++S+ E+ L Q+ + S + EM
Sbjct: 496 --MSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPR 553
Query: 910 QMREQQSWVISPPQP---------SPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSP 960
Q + S +PP P S +Q D P K +++I+P + P + S
Sbjct: 554 QNSDPTS--ENPPLPTRIEKFDRSSWLRQEEDI-PPKVPQRTTSISPALARKNSPGNGSA 610
Query: 961 QSSNRKSASFSVKSQRTPRPNELKITPLNRTLTPPRSVDSLP 1002
S + R + +PL RT + S S P
Sbjct: 611 LGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTP 652
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 52.0 bits (123), Expect = 4e-06
Identities = 32/102 (31%), Positives = 54/102 (52%), Gaps = 4/102 (3%)
Query: 1172 LEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKKEDERARREFIRQEYMRRKQL 1231
LE++ RREKE LRKQQ + H +E+ RR+ E R + E E R++ Q R Q
Sbjct: 405 LEEQQRREKE--LRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQR 462
Query: 1232 KLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHIESPKTPIKGP 1273
+L ++ D ++ + Q +Q+ K ++ H + +P + P
Sbjct: 463 QLKQERDYLVSLQHQRQEQRPVEKKPLY--HYKEGMSPSEKP 502
Score = 45.8 bits (107), Expect = 3e-04
Identities = 34/125 (27%), Positives = 66/125 (52%), Gaps = 14/125 (11%)
Query: 1156 DDQKAENDMAMKRAALLEKRLRREKETQLRK-----QQLEAEMEHKKEETRRKTEEERQK 1210
+ Q+ EN+ KR L E++ R E++ + R+ Q+ E E+ ++E +R+ EE+ +
Sbjct: 374 EQQQRENE-EHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMR 432
Query: 1211 KEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHIESPKTPI 1270
+E+ER R E QEY +RKQL+ + + + + K++R + H + P+
Sbjct: 433 REEERRRAEH-EQEY-KRKQLEEQRQAERLQR------QLKQERDYLVSLQHQRQEQRPV 484
Query: 1271 KGPPV 1275
+ P+
Sbjct: 485 EKKPL 489
Score = 44.7 bits (104), Expect = 7e-04
Identities = 38/179 (21%), Positives = 76/179 (42%), Gaps = 15/179 (8%)
Query: 1082 CLTPNEDQLNQPTEPPPKPVFPPTAPKNVNLIEVSLSD------LKPPEKADVPVEKYDG 1135
CL N Q TE K F P N + + L D K EK + E
Sbjct: 269 CLVKNHSQ-RPATEQLMKHPFIRDQP-NERQVRIQLKDHIDRTKKKRGEKDETEYEYSGS 326
Query: 1136 ESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEH 1195
E ++E+ D + + ++R L + +E+ LR+QQLE +
Sbjct: 327 EEEEEENDSGEP-------SSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRE 379
Query: 1196 KKEETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQR 1254
+E R+ E +++ E+++ +R + ++ R K+L+ ++ + Q+ +++++R
Sbjct: 380 NEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERR 438
Score = 36.6 bits (83), Expect = 0.18
Identities = 64/282 (22%), Positives = 113/282 (40%), Gaps = 38/282 (13%)
Query: 744 QLLASEMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGISPLRE 803
QLLA + + E++RR E Q+++ E KQ+++ R + ++++ E
Sbjct: 386 QLLAERQKRIEEQKEQRRRLEEQQRREKE--LRKQQEREQRRHYEEQMRRE--------E 435
Query: 804 EAAGAEDEKVYTDRAKEKESQKTDGQRS-KSLADIKESMENPQAKWLKSPTTPIDPEKQW 862
E AE E+ Y + E++ Q QR K D S+++ + + P+ K+
Sbjct: 436 ERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEG 495
Query: 863 NLASPSEE------------TLNEGEILEYTKSI-EKLNSSLHFLQQEMQRLSLQQEMLM 909
SPSE+ ++G L ++S+ E+ L Q+ + S + EM
Sbjct: 496 --MSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPR 553
Query: 910 QMREQQSWVISPPQP---------SPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSP 960
Q + S +PP P S +Q D P K +++I+P + P + S
Sbjct: 554 QNSDPTS--ENPPLPTRIEKFDRSSWLRQEEDI-PPKVPQRTTSISPALARKNSPGNGSA 610
Query: 961 QSSNRKSASFSVKSQRTPRPNELKITPLNRTLTPPRSVDSLP 1002
S + R + +PL RT + S S P
Sbjct: 611 LGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTP 652
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 52.0 bits (123), Expect = 4e-06
Identities = 32/102 (31%), Positives = 54/102 (52%), Gaps = 4/102 (3%)
Query: 1172 LEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKKEDERARREFIRQEYMRRKQL 1231
LE++ RREKE LRKQQ + H +E+ RR+ E R + E E R++ Q R Q
Sbjct: 405 LEEQQRREKE--LRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQR 462
Query: 1232 KLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHIESPKTPIKGP 1273
+L ++ D ++ + Q +Q+ K ++ H + +P + P
Sbjct: 463 QLKQERDYLVSLQHQRQEQRPVEKKPLY--HYKEGMSPSEKP 502
Score = 45.8 bits (107), Expect = 3e-04
Identities = 34/125 (27%), Positives = 66/125 (52%), Gaps = 14/125 (11%)
Query: 1156 DDQKAENDMAMKRAALLEKRLRREKETQLRK-----QQLEAEMEHKKEETRRKTEEERQK 1210
+ Q+ EN+ KR L E++ R E++ + R+ Q+ E E+ ++E +R+ EE+ +
Sbjct: 374 EQQQRENE-EHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMR 432
Query: 1211 KEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHIESPKTPI 1270
+E+ER R E QEY +RKQL+ + + + + K++R + H + P+
Sbjct: 433 REEERRRAEH-EQEY-KRKQLEEQRQAERLQR------QLKQERDYLVSLQHQRQEQRPV 484
Query: 1271 KGPPV 1275
+ P+
Sbjct: 485 EKKPL 489
Score = 44.7 bits (104), Expect = 7e-04
Identities = 38/179 (21%), Positives = 76/179 (42%), Gaps = 15/179 (8%)
Query: 1082 CLTPNEDQLNQPTEPPPKPVFPPTAPKNVNLIEVSLSD------LKPPEKADVPVEKYDG 1135
CL N Q TE K F P N + + L D K EK + E
Sbjct: 269 CLVKNHSQ-RPATEQLMKHPFIRDQP-NERQVRIQLKDHIDRTKKKRGEKDETEYEYSGS 326
Query: 1136 ESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEH 1195
E ++E+ D + + ++R L + +E+ LR+QQLE +
Sbjct: 327 EEEEEENDSGEP-------SSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRE 379
Query: 1196 KKEETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQR 1254
+E R+ E +++ E+++ +R + ++ R K+L+ ++ + Q+ +++++R
Sbjct: 380 NEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERR 438
Score = 31.6 bits (70), Expect = 5.9
Identities = 34/140 (24%), Positives = 64/140 (45%), Gaps = 13/140 (9%)
Query: 744 QLLASEMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGISPLRE 803
QLLA + + E++RR E Q+++ E KQ+++ R + ++++ E
Sbjct: 386 QLLAERQKRIEEQKEQRRRLEEQQRREKE--LRKQQEREQRRHYEEQMRRE--------E 435
Query: 804 EAAGAEDEKVYTDRAKEKESQKTDGQRS-KSLADIKESMENPQAKWLKSPTTPIDPEKQW 862
E AE E+ Y + E++ Q QR K D S+++ + + P+ K+
Sbjct: 436 ERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEG 495
Query: 863 NLASPSEETLNEGEILEYTK 882
SPSE+ E+ E ++
Sbjct: 496 --MSPSEKPAWAKEVEERSR 513
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 52.0 bits (123), Expect = 4e-06
Identities = 32/102 (31%), Positives = 54/102 (52%), Gaps = 4/102 (3%)
Query: 1172 LEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKKEDERARREFIRQEYMRRKQL 1231
LE++ RREKE LRKQQ + H +E+ RR+ E R + E E R++ Q R Q
Sbjct: 405 LEEQQRREKE--LRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQR 462
Query: 1232 KLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHIESPKTPIKGP 1273
+L ++ D ++ + Q +Q+ K ++ H + +P + P
Sbjct: 463 QLKQERDYLVSLQHQRQEQRPVEKKPLY--HYKEGMSPSEKP 502
Score = 45.8 bits (107), Expect = 3e-04
Identities = 34/125 (27%), Positives = 66/125 (52%), Gaps = 14/125 (11%)
Query: 1156 DDQKAENDMAMKRAALLEKRLRREKETQLRK-----QQLEAEMEHKKEETRRKTEEERQK 1210
+ Q+ EN+ KR L E++ R E++ + R+ Q+ E E+ ++E +R+ EE+ +
Sbjct: 374 EQQQRENE-EHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMR 432
Query: 1211 KEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHIESPKTPI 1270
+E+ER R E QEY +RKQL+ + + + + K++R + H + P+
Sbjct: 433 REEERRRAEH-EQEY-KRKQLEEQRQAERLQR------QLKQERDYLVSLQHQRQEQRPV 484
Query: 1271 KGPPV 1275
+ P+
Sbjct: 485 EKKPL 489
Score = 44.7 bits (104), Expect = 7e-04
Identities = 38/179 (21%), Positives = 76/179 (42%), Gaps = 15/179 (8%)
Query: 1082 CLTPNEDQLNQPTEPPPKPVFPPTAPKNVNLIEVSLSD------LKPPEKADVPVEKYDG 1135
CL N Q TE K F P N + + L D K EK + E
Sbjct: 269 CLVKNHSQ-RPATEQLMKHPFIRDQP-NERQVRIQLKDHIDRTKKKRGEKDETEYEYSGS 326
Query: 1136 ESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEH 1195
E ++E+ D + + ++R L + +E+ LR+QQLE +
Sbjct: 327 EEEEEENDSGEP-------SSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRE 379
Query: 1196 KKEETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQR 1254
+E R+ E +++ E+++ +R + ++ R K+L+ ++ + Q+ +++++R
Sbjct: 380 NEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERR 438
Score = 31.6 bits (70), Expect = 5.9
Identities = 34/140 (24%), Positives = 64/140 (45%), Gaps = 13/140 (9%)
Query: 744 QLLASEMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGISPLRE 803
QLLA + + E++RR E Q+++ E KQ+++ R + ++++ E
Sbjct: 386 QLLAERQKRIEEQKEQRRRLEEQQRREKE--LRKQQEREQRRHYEEQMRRE--------E 435
Query: 804 EAAGAEDEKVYTDRAKEKESQKTDGQRS-KSLADIKESMENPQAKWLKSPTTPIDPEKQW 862
E AE E+ Y + E++ Q QR K D S+++ + + P+ K+
Sbjct: 436 ERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEG 495
Query: 863 NLASPSEETLNEGEILEYTK 882
SPSE+ E+ E ++
Sbjct: 496 --MSPSEKPAWAKEVEERSR 513
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 52.0 bits (123), Expect = 4e-06
Identities = 52/213 (24%), Positives = 100/213 (46%), Gaps = 30/213 (14%)
Query: 1027 EPQLKESKPKEEVK---KEELESKGTLEQRGHNPEEKEIKPFEST-----VSEVLSLPVT 1078
E QL+ K E + +E+L + LE R EEK+ + E E
Sbjct: 190 EEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKR 249
Query: 1079 ETVCLTPNEDQLNQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGESD 1138
ETV L E++L + P+ ++ L+ E+ ++ E+ + E
Sbjct: 250 ETV-LRKEEEKLQEEE------------PQRQRELQEEEEQLRKLERQELRRERQEEEQQ 296
Query: 1139 KEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKE 1198
+++ +Q++ +K E + ++ E++ RRE++ + R+QQL E E ++E
Sbjct: 297 QQRLRREQQL--------RRKQEEERREQQEERREQQERREQQEERREQQLRREQEERRE 348
Query: 1199 -ETRRKTEEERQKKEDERARREFIRQEYMRRKQ 1230
+ RR+ EEER++++ R + E R++ +RR+Q
Sbjct: 349 QQLRREQEEERREQQLRREQEEERREQQLRREQ 381
Score = 52.0 bits (123), Expect = 4e-06
Identities = 109/539 (20%), Positives = 224/539 (41%), Gaps = 66/539 (12%)
Query: 733 ETGLPQGRDTTQLLASEMVHLRMKLEEKRRAIEAQ--KKKMEAAFTKQRQKMGRTAFLTV 790
E L Q RD + E R + + K R E Q +++ E F ++ Q++ +
Sbjct: 1405 EQQLRQDRDR-KFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKF 1463
Query: 791 VKKKGDGISPLREEAAGAEDEKVYTDRA-KEKESQKTDGQRSKSLADIKESMENPQAKWL 849
++ + + REE E+ DR E+E Q +R + + + + P+ K+L
Sbjct: 1464 --REEEQLLQEREEQQLHRQER---DRKFLEEEQQLRRQERDRKFREQELRSQEPERKFL 1518
Query: 850 KSPTTPIDPEKQWNLASPSEETLNEGEILEYTKSIEKLNSSLHFLQQEMQRLSLQQEMLM 909
+ E+Q + + L E + L + ++ +Q+ R ++E L
Sbjct: 1519 EE-------EQQLHRQQRQRKFLQEEQQLRRQERGQQR-------RQDRDRKFREEEQLR 1564
Query: 910 QMREQQSWVISPPQPSPQKQIRDFKPSKQ-AGLSSAIAPFSSDSPRPTHPSPQSSNRKSA 968
Q RE+Q Q S Q++ R F+ +Q F D + Q R+
Sbjct: 1565 QEREEQ-------QLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQER 1617
Query: 969 SFSVKSQRTPRPNELKITPLNRTLTPPRSVDSLPRLRRFSPSQVPIQTRSFVCFGDDGEP 1028
+ E + L+R + ++ P+LRR Q Q R E
Sbjct: 1618 DRKFREDEQLL-QEREEQQLHRQERDRKFLEEEPQLRRQEREQ---QLRHDRDRKFREEE 1673
Query: 1029 QLKESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLTPNED 1088
QL + +++++++E + K E++ +E+E K + E L E E+
Sbjct: 1674 QLLQEGEEQQLRRQERDRKFREEEQQLRRQERERK----FLQEEQQLRRQELERKFREEE 1729
Query: 1089 QLNQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGESDKEQFDDDQKV 1148
QL Q TE + ++ + PE+ + + + + + +F +++++
Sbjct: 1730 QLRQETEQEQ-------LRRQERYRKILEEEQLRPEREEQQLRRQERD---RKFREEEQL 1779
Query: 1149 CCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQ-LRKQQLEAEMEHKKEETRRKTEEE 1207
+ + E+D + E++LR+E+E Q LR QQ + + ++E+ + + +E+
Sbjct: 1780 RQEREEQQLRSQESDRKFRE----EEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQ 1835
Query: 1208 RQKKEDE---RARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHI 1263
R ++E + RA +F QE RR++ +L ++ + K++++R + + +HI
Sbjct: 1836 RLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQ---------KRRQERERKLREEHI 1885
Score = 50.8 bits (120), Expect = 9e-06
Identities = 107/520 (20%), Positives = 210/520 (40%), Gaps = 64/520 (12%)
Query: 749 EMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGISPLREEAAGA 808
E + + E KRR ++Q++K ++R++ R ++ + + REE
Sbjct: 1297 EQLEREEQKEAKRRDRKSQEEKQ--LLREEREEKRRRQETDRKFREEEQLLQEREEQPLR 1354
Query: 809 EDEKVYTDRAKEKESQKTDGQRSKSLADIKE-SMENPQAKWLKSPTTPIDPEKQWNLASP 867
E+ DR +E + Q K L + + + + K+LK E++ L
Sbjct: 1355 RQER---DRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQD 1411
Query: 868 SEETLNEGE-----------ILEYTKSIEKLNSSLHFLQQEMQRLSLQQEMLMQMREQQS 916
+ E E E + + + FL++E Q L+QE + RE++
Sbjct: 1412 RDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQ---LRQERHRKFREEEQ 1468
Query: 917 WVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSPQSSNRKSASFSVKSQR 976
+ + +Q RD K F + + Q +RK ++SQ
Sbjct: 1469 LLQEREEQQLHRQERDRK-------------FLEEEQQLRR---QERDRKFREQELRSQE 1512
Query: 977 TPRPNELKITPLNRTLTPPRSVDSLPRLRRFSPSQVPIQTRSFVCFGDDGEPQLKESKPK 1036
R + L+R + + +LRR Q Q R F + E QL++ + +
Sbjct: 1513 PERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRK-FRE--EEQLRQEREE 1569
Query: 1037 EEVKKEELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLTPNEDQLNQPTEP 1096
+++ ++E + K LE++ +E+E K E + + + QL Q +
Sbjct: 1570 QQLSRQERDRKFRLEEQKVRRQEQERKFMED----------EQQLRRQEGQQQLRQERDR 1619
Query: 1097 PPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGESDKEQFDDDQKVCCGFFFKD 1156
+ + + D K E + P + + + D D+K F ++
Sbjct: 1620 KFREDEQLLQEREEQQLHRQERDRKFLE--EEPQLRRQEREQQLRHDRDRK-----FREE 1672
Query: 1157 DQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKKEDERA 1216
+Q + + R RE+E QLR+Q+ E + ++++ RR+ E ER+ +E+E+
Sbjct: 1673 EQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQ-ELERKFREEEQL 1731
Query: 1217 RREFIRQEYMRRKQ--LKLMEDMDTVIKPRPQVVKQKKQR 1254
R+E QE +RR++ K++E+ RP+ +Q+ +R
Sbjct: 1732 RQE-TEQEQLRRQERYRKILEEEQL----RPEREEQQLRR 1766
Score = 48.5 bits (114), Expect = 5e-05
Identities = 25/116 (21%), Positives = 70/116 (60%), Gaps = 6/116 (5%)
Query: 1155 KDDQKAENDMAMKRAALLEK--RLRREKETQLRKQQLEAEMEHKK----EETRRKTEEER 1208
K+++K + + ++ L E+ +LR+ + +LR+++ E E + ++ ++ RRK EEER
Sbjct: 255 KEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER 314
Query: 1209 QKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHIE 1264
+++++ER ++ R++ R++ +L + + + + + +++++R + + R+ E
Sbjct: 315 REQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEE 370
Score = 48.5 bits (114), Expect = 5e-05
Identities = 20/76 (26%), Positives = 48/76 (63%)
Query: 1155 KDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKKEDE 1214
+ +++ E + ++ E++LRRE+E + R+QQL E E ++ E + + E++ ++++
Sbjct: 330 QQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQL 389
Query: 1215 RARREFIRQEYMRRKQ 1230
R ++ R++ +RR+Q
Sbjct: 390 RREQQLRREQQLRREQ 405
Score = 48.5 bits (114), Expect = 5e-05
Identities = 28/111 (25%), Positives = 62/111 (55%), Gaps = 1/111 (0%)
Query: 1155 KDDQKAENDMAMKRAA-LLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKKED 1213
K +Q+ D +KR ++RL+RE+E +L ++ E+E ++E RR+ +R++ E+
Sbjct: 568 KREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEE 627
Query: 1214 ERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHIE 1264
ER ++ +E R+Q +L + + R + +++++ + + R+H E
Sbjct: 628 ERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEE 678
Score = 47.8 bits (112), Expect = 8e-05
Identities = 36/139 (25%), Positives = 72/139 (51%), Gaps = 19/139 (13%)
Query: 1125 KADVPVEKYDGESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQL 1184
K + E+++ E K+Q DQ ++++ E R LE+ RRE++ +
Sbjct: 459 KREEETERHEQERRKQQLKRDQ---------EEERRE------RWLKLEEEERREQQER- 502
Query: 1185 RKQQLEAEMEHKKEETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPR 1244
R+QQL E E ++E+ ++ EEE + ++ R+ ++ R++ RR+QL E+ + + R
Sbjct: 503 REQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQER 562
Query: 1245 PQVVKQKKQRPKSIHRDHI 1263
+ Q+ +R + RD +
Sbjct: 563 RE---QRLKREQEERRDQL 578
Score = 47.0 bits (110), Expect = 1e-04
Identities = 26/109 (23%), Positives = 64/109 (58%), Gaps = 6/109 (5%)
Query: 1155 KDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKKEDE 1214
+++++ + + ++ E++LRRE+E + R+QQL E E ++ E + + E+E +++E +
Sbjct: 318 QEERREQQERREQQEERREQQLRREQE-ERREQQLRREQEEERREQQLRREQEEERREQQ 376
Query: 1215 RARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQ--RPKSIHRD 1261
R + +R+E R++ +L + R Q +++++Q R + + R+
Sbjct: 377 LRREQQLRREQQLRREQQLRREQQL---RREQQLRREQQLRREQQLRRE 422
Score = 46.6 bits (109), Expect = 2e-04
Identities = 93/507 (18%), Positives = 183/507 (36%), Gaps = 99/507 (19%)
Query: 732 EETGLPQGRDTTQLLASEMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQKMGRTA----F 787
EE L + + L E R + + K R E + ++ E F ++ Q++ R F
Sbjct: 1474 EEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKF 1533
Query: 788 LTV---VKKKGDGISPLREEAAGAEDEKVYTDRAKEKESQKTDGQRSKSLADIKESMENP 844
L ++++ G ++ +E+ +E++ + + R L + K +
Sbjct: 1534 LQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQ 1593
Query: 845 QAKWLKSPTTPIDPEKQWNLASPSEETLNEGEILEYTKSIEKLNSSLHFLQQEMQRLSLQ 904
+ K+++ E Q L + E E L E+ LH +++ + L +
Sbjct: 1594 ERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQ----EREEQQLHRQERDRKFLEEE 1649
Query: 905 QEMLMQMREQQSWVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSPQSSN 964
++ Q REQQ + ++ R+ + Q G + D
Sbjct: 1650 PQLRRQEREQQL------RHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQ 1703
Query: 965 RKSASFSVKSQRTPRPNELKITPLNRTLTPPRSVDSLPRLRRFSPSQVPIQTRSFVCFGD 1024
+ F + Q+ R + L + L R R+ R +
Sbjct: 1704 ERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERY---------RKIL---- 1750
Query: 1025 DGEPQLKESKPKEEVKKEELESK-GTLEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCL 1083
E QL+ + +++++++E + K EQ EE++++ ES
Sbjct: 1751 -EEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRK------------- 1796
Query: 1084 TPNEDQLNQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGESDKEQFD 1143
E+QL Q E L+P ++ KY E ++ Q +
Sbjct: 1797 FREEEQLRQEREE---------------------QQLRPQQRDG----KYRWEEEQLQLE 1831
Query: 1144 DDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRK 1203
+ E+RLR+E++ Q R ++ A E + E +
Sbjct: 1832 EQ---------------------------EQRLRQERDRQYRAEEQFATQEKSRREEQEL 1864
Query: 1204 TEEERQKKEDERARREFIRQEYMRRKQ 1230
+EE QK+ ER R+ +R+E++RR+Q
Sbjct: 1865 WQEEEQKRRQERERK--LREEHIRRQQ 1889
Score = 46.2 bits (108), Expect = 2e-04
Identities = 98/529 (18%), Positives = 219/529 (41%), Gaps = 82/529 (15%)
Query: 749 EMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGISPLREEAAGA 808
E + R+K EE R +E ++++ + ++ ++ R L +++ LR E
Sbjct: 596 ERLEQRLKREEVER-LEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQER 654
Query: 809 EDEKVYTDRAKEKESQ--KTDGQRSKSLADIKESMENPQAKWLKSPTTPIDPEKQWNLAS 866
++++ + +E+ Q K + + + ++ E + + +KS P+ QW L S
Sbjct: 655 REQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRI----PKWQWQLES 710
Query: 867 PSEETLNEGEILEYTKSIEKLNSSLHFLQQEMQRLSLQQEMLMQMREQQSWVISPPQPSP 926
++ ++ Y++ ++ Q+E +R ++E +Q +E++ + Q
Sbjct: 711 EADARQSK----VYSRPRKQEGQRRRQEQEEKRR---RRESELQWQEEER---AHRQQQE 760
Query: 927 QKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSPQSSNRKSASFSVKSQRTPRPNELKIT 986
++Q RDF QA S + R SA ++ QR
Sbjct: 761 EEQRRDFTWQWQA----------------EEKSERGRQRLSARPPLREQR---------- 794
Query: 987 PLNRTLTPPRSVDSLPRLRRFSPSQVPIQTRSFVCFGDDGEPQLKESKPKEEVKKEELES 1046
R L R+ + R +RF P + + R + E +L+ + +E++++ E
Sbjct: 795 --ERQL---RAEERQQREQRFLPEEEEKEQRRRQ--RREREKELQFLEEEEQLQRRERAQ 847
Query: 1047 KGTLEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLTPNEDQLNQPTEPPPKPVFPPTA 1106
+ E+ G +++ + E + + E++ + KP
Sbjct: 848 QLQEEEDGLQEDQERRRSQEQRRDQKWRWQL--------EEERKRRRHTLYAKPALQEQL 899
Query: 1107 PKNVNLIEVSLSDLKPPEKADVPVEKYDGESDKEQFDDDQKVCCGFFFKDDQKAENDMAM 1166
K L++ +L+ E+ EK + + Q+ +++++ +++Q +
Sbjct: 900 RKEQQLLQEEEEELQREER-----EKRRRQEQERQYREEEQLQQ----EEEQLLREEREK 950
Query: 1167 KRAALLEKRLRREKETQLRKQQL---------EAEMEHKKEETRRKTEEERQKKEDERAR 1217
+R E++ R++K+ Q +++QL E E K E +EE Q +ER +
Sbjct: 951 RRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREK 1010
Query: 1218 REFIRQEYMR--RKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHIE 1264
R RQE+ R RK+ +L ++ + ++ R + K++ Q + +R+ E
Sbjct: 1011 RR--RQEWERQYRKKDELQQEEEQLL--REEREKRRLQERERQYREEEE 1055
Score = 46.2 bits (108), Expect = 2e-04
Identities = 51/243 (20%), Positives = 113/243 (46%), Gaps = 34/243 (13%)
Query: 1027 EPQLKESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLTPN 1086
E QL + + +EE+++EE E + EQ EE++++ E E +
Sbjct: 902 EQQLLQEE-EEELQREEREKRRRQEQERQYREEEQLQQEE------------EQLLREER 948
Query: 1087 EDQLNQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGESDKEQFDDDQ 1146
E + Q E + K + E L +P ++ EK E ++ Q +++Q
Sbjct: 949 EKRRRQERERQYRK------DKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQ 1002
Query: 1147 KVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQ-----LEAEMEHKKEETR 1201
+++++ +R + L++E+E LR+++ E E ++++EE
Sbjct: 1003 ------LLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEEL 1056
Query: 1202 RKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRD 1261
++ EE+ +E E RR+ + ++Y RK+ +L ++ + +++ P+ K+++Q + R+
Sbjct: 1057 QQEEEQLLGEERETRRRQELERQY--RKEEELQQEEEQLLREEPE--KRRRQERERQCRE 1112
Query: 1262 HIE 1264
E
Sbjct: 1113 EEE 1115
Score = 45.8 bits (107), Expect = 3e-04
Identities = 35/113 (30%), Positives = 62/113 (54%), Gaps = 15/113 (13%)
Query: 1157 DQKAENDMAMKRAALL--EKRLRREKETQLRKQQLEAEMEHKKEET-RRKTEEER--QKK 1211
+Q+ + ++R L E++LRRE++ + R+QQL E + ++E+ RR+ EEER QK
Sbjct: 380 EQQLRREQQLRREQQLRREQQLRREQQLR-REQQLRREQQLRREQQLRREQEEERHEQKH 438
Query: 1212 EDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHIE 1264
E ER + R++ RR LK E+ + ++++R + + RD E
Sbjct: 439 EQERREQRLKREQEERRDWLKREEETER---------HEQERRKQQLKRDQEE 482
Score = 45.8 bits (107), Expect = 3e-04
Identities = 26/106 (24%), Positives = 59/106 (55%), Gaps = 4/106 (3%)
Query: 1157 DQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKKEDERA 1216
+Q+ + + +R L + E + RKQQL+ + E ++ E K EEE ++++ ER
Sbjct: 444 EQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERR 503
Query: 1217 RREFIRQEYMRRKQ-LKLMEDMDTV---IKPRPQVVKQKKQRPKSI 1258
++ R++ RR+Q LK E+ + + ++ Q+ +++++R + +
Sbjct: 504 EQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL 549
Score = 45.1 bits (105), Expect = 5e-04
Identities = 34/150 (22%), Positives = 79/150 (52%), Gaps = 11/150 (7%)
Query: 1114 EVSLSDLKPPEKADVPVEKYDGESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLE 1173
E L + E+ + E+ + + +EQ ++ ++ + +Q+ + ++R E
Sbjct: 303 EQQLRRKQEEERREQQEERREQQERREQQEERREQQ----LRREQEERREQQLRREQEEE 358
Query: 1174 KR---LRREKETQLRKQQLEAEMEHKKEETRRKTEE---ERQKKEDERARREF-IRQEYM 1226
+R LRRE+E + R+QQL E + ++E+ R+ ++ E+Q + +++ RRE +R+E
Sbjct: 359 RREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 418
Query: 1227 RRKQLKLMEDMDTVIKPRPQVVKQKKQRPK 1256
R++ +L + + + ++++QR K
Sbjct: 419 LRREQQLRREQEEERHEQKHEQERREQRLK 448
Score = 45.1 bits (105), Expect = 5e-04
Identities = 30/128 (23%), Positives = 67/128 (52%), Gaps = 11/128 (8%)
Query: 1155 KDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQ----K 1210
+ +Q+ + +R LL++ + E + R+Q+L+ E E ++++ ++ EE RQ +
Sbjct: 533 RSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKR 592
Query: 1211 KEDERARREFIRQEYMRRKQLKLMEDMDTVIKP----RPQVVK---QKKQRPKSIHRDHI 1263
+++ER + R+E R +Q + E +P R Q++K Q+++R + + R+
Sbjct: 593 EQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQ 652
Query: 1264 ESPKTPIK 1271
E + +K
Sbjct: 653 ERREQRLK 660
Score = 43.9 bits (102), Expect = 0.001
Identities = 31/118 (26%), Positives = 66/118 (55%), Gaps = 12/118 (10%)
Query: 1155 KDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKKEDE 1214
+++Q + +R LE++ R+E+E Q ++QL E + E RR+ E ERQ +E+E
Sbjct: 1059 EEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLRE----EPEKRRRQERERQCREEE 1114
Query: 1215 RARRE---FIRQEYMRRKQLKL---MEDMDTVIKPRPQVVKQ--KKQRPKSIHRDHIE 1264
++E +R+E +R++ +L + + V + Q++++ +K+R + + R + E
Sbjct: 1115 ELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYRE 1172
Score = 42.0 bits (97), Expect = 0.004
Identities = 99/549 (18%), Positives = 204/549 (37%), Gaps = 72/549 (13%)
Query: 729 QIPEETGLPQGRDTTQLLASEMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQKMGRTAFL 788
Q EE Q R+ Q L E L+ E +R + + +K ++R++ T +
Sbjct: 832 QFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYA 891
Query: 789 TVVKKKGDGISPLREEAAGAEDEKVYTDRAKEKESQKTDGQRSKSLADIKESMENPQAKW 848
++ LR+E ++E+ R + ++ ++ + +R + + E +
Sbjct: 892 KPALQE-----QLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLRE 946
Query: 849 LKSPTTPIDPEKQWN----LASPSEETLNEGEILEYTKSIEKLNSSLHFLQQEMQRLSLQ 904
+ + E+Q+ L E+ L E + EK LQQE ++L +
Sbjct: 947 EREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLRE 1006
Query: 905 QEMLMQMREQQSWVISPPQPSPQKQIR---DFKPSKQAGLSSAIAPFSSDSPRPTHPSPQ 961
+ + R +Q W ++Q R + + ++ L + +
Sbjct: 1007 ER---EKRRRQEW---------ERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEE 1054
Query: 962 SSNRKSASFSVKSQRTPRPNELKITPLNRTLTPPRSVDSLPRLRRFSPSQVPIQTRSFVC 1021
++ + + T R EL+ + +L R P + Q R C
Sbjct: 1055 ELQQEEEQLLGEERETRRRQELE----RQYRKEEELQQEEEQLLREEPEKRRRQERERQC 1110
Query: 1022 FGDDGEPQLKESKPKEEVKK---EELESKGTLEQR---------GHNPEEKEIKPFESTV 1069
++ Q +E +EE +K +ELE + E+ PE++ + E
Sbjct: 1111 REEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQY 1170
Query: 1070 SEVLSLPVTETVCLTPNEDQLNQPTEPPPKPVFPPTAPKNVNLI--EVSLSDLKPPEKAD 1127
E L E L +++ Q E + K E SDLK
Sbjct: 1171 REEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLK------ 1224
Query: 1128 VPVEKYDGESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQ 1187
+ E +KE D KV C + EN+ + R+ +++QLR +
Sbjct: 1225 -----WQWEPEKENAVRDNKVYC-------KGRENE-----------QFRQLEDSQLRDR 1261
Query: 1188 QLEAEMEHKKEETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQV 1247
Q + +++H E + + E+ +++ +R R F +E + R++ K + D + Q+
Sbjct: 1262 QSQQDLQHLLGEQQERDREQERRRWQQR-DRHFPEEEQLEREEQKEAKRRDRKSQEEKQL 1320
Query: 1248 VKQKKQRPK 1256
++++++ +
Sbjct: 1321 LREEREEKR 1329
Score = 41.6 bits (96), Expect = 0.006
Identities = 50/256 (19%), Positives = 110/256 (42%), Gaps = 49/256 (19%)
Query: 1027 EPQLKESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLTPN 1086
E QL+ + +EE ++E+ E + ++R EE+ + E
Sbjct: 303 EQQLR--RKQEEERREQQEERREQQERREQQEERREQQLRREQEE-------------RR 347
Query: 1087 EDQLNQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGESDKEQFDDDQ 1146
E QL + E + E L + E+ + + + ++Q +Q
Sbjct: 348 EQQLRREQEEERR--------------EQQLRREQEEERREQQLRREQQLRREQQLRREQ 393
Query: 1147 KVCCGFFFKDDQKAENDMAMKRAALL--EKRLRREKETQL---------RKQQLEAEMEH 1195
++ + +Q+ + ++R L E++LRRE+E + R+Q+L+ E E
Sbjct: 394 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEE 453
Query: 1196 KKEETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRP 1255
+++ +R+ E ER ++E + + + ++E R + LKL E+ + +Q+++R
Sbjct: 454 RRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEE---------ERREQQERRE 504
Query: 1256 KSIHRDHIESPKTPIK 1271
+ + R+ E + +K
Sbjct: 505 QQLRREQEERREQRLK 520
Score = 41.6 bits (96), Expect = 0.006
Identities = 103/540 (19%), Positives = 209/540 (38%), Gaps = 86/540 (15%)
Query: 738 QGRDTTQLLASEMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDG 797
Q R+ +L E LR + E++R+ E Q ++ E ++R++ R D
Sbjct: 1169 QYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDE---------DQ 1219
Query: 798 ISPLR-----EEAAGAEDEKVYTDRAKEKE-------SQKTDGQRSKSLADI-----KES 840
S L+ E+ D KVY + +E E SQ D Q + L + +
Sbjct: 1220 RSDLKWQWEPEKENAVRDNKVYC-KGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERD 1278
Query: 841 MENPQAKWLKSPTTPIDPEKQWNLASPSEETLNEGEILEYTKSIEKLNSSLHFLQQEMQR 900
E + +W +Q + P EE L E E + K L++E +
Sbjct: 1279 REQERRRW-----------QQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREE 1327
Query: 901 LSLQQEMLMQMREQQSWVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSP 960
+QE + RE++ + + ++Q RD K F + R
Sbjct: 1328 KRRRQETDRKFREEEQLLQEREEQPLRRQERDRK-------------FREEELR-----H 1369
Query: 961 QSSNRKSASFSVKSQRTPR-PNELKITPLNRTLTPPRSVDSL--PRLRRFSPSQVPIQTR 1017
Q RK F + QR R E K + L L R R+F + + +
Sbjct: 1370 QEQGRK---FLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQ 1426
Query: 1018 SFVCFGDDGEPQLKESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPV 1077
+ E Q++ ++E +++ LE + L Q H +E + + + L
Sbjct: 1427 ERDRKFREEEQQVR----RQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQE 1482
Query: 1078 TETVCLTPNEDQLNQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGES 1137
+ L E QL + ++ E L +P K ++ +
Sbjct: 1483 RDRKFL-EEEQQLRR-------------QERDRKFREQELRSQEPERKFLEEEQQLHRQQ 1528
Query: 1138 DKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREK-ETQLRKQQLEAEMEHK 1196
+ +F +++ ++ + D + E++LR+E+ E QL +Q+ + + +
Sbjct: 1529 RQRKFLQEEQQLRRQERGQQRRQDRDRKFRE----EEQLRQEREEQQLSRQERDRKFRLE 1584
Query: 1197 KEETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPK 1256
+++ RR+ +E + +++++ RR+ +Q+ + + K ED + +++ R + +++R +
Sbjct: 1585 EQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRED-EQLLQEREEQQLHRQERDR 1643
Score = 40.8 bits (94), Expect = 0.010
Identities = 31/138 (22%), Positives = 72/138 (52%), Gaps = 12/138 (8%)
Query: 1136 ESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEH 1195
E +K + + ++ C +++++ + + EKR R+E E Q R+++ E++
Sbjct: 1097 EPEKRRRQERERQC-----REEEELQQEEEQLLREEREKRRRQELERQYREEE---EVQQ 1148
Query: 1196 KKEETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKK--Q 1253
++E+ R+ E+R+++E ER RE +E + ++ L E+ + + R + ++++ Q
Sbjct: 1149 EEEQLLREEPEKRRRQELERQYRE--EEELQQEEEQLLREEQEKRRQERERQYREEEELQ 1206
Query: 1254 RPKSIHRDHIESPKTPIK 1271
R K R E ++ +K
Sbjct: 1207 RQKRKQRYRDEDQRSDLK 1224
Score = 40.8 bits (94), Expect = 0.010
Identities = 24/101 (23%), Positives = 50/101 (49%)
Query: 1159 KAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKKEDERARR 1218
+ E ++ + LL + + + +L +Q E E ++EE + E+E++++E ER R
Sbjct: 1141 REEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYR 1200
Query: 1219 EFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIH 1259
E + +RKQ ED + +K + + K+ R ++
Sbjct: 1201 EEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVY 1241
Score = 38.1 bits (87), Expect = 0.063
Identities = 31/140 (22%), Positives = 69/140 (49%), Gaps = 21/140 (15%)
Query: 1138 DKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKK 1197
D+ Q +D ++ F D++ E + +R +KR +E+E ++Q E + ++
Sbjct: 112 DRRQEEDQRR-----FEPRDRQLEEEPGQRRR---QKRQEQERELAEGEEQSEKQERLEQ 163
Query: 1198 EETRRKTEE------ERQKKEDERARREFIR-------QEYMRRKQLKLMEDMDTVIKPR 1244
+ +R+ EE E Q++E+ RA E ++ +E+ +QL+ E ++ K R
Sbjct: 164 RDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGR 223
Query: 1245 PQVVKQKKQRPKSIHRDHIE 1264
+ +Q+++R + ++ E
Sbjct: 224 EEKQQQRRERQDRVFQEEEE 243
Score = 37.7 bits (86), Expect = 0.083
Identities = 30/124 (24%), Positives = 65/124 (52%), Gaps = 11/124 (8%)
Query: 1136 ESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEA-EME 1194
E ++ + +++Q C ++ E + + L ++ R EK+ Q R++Q + E
Sbjct: 182 EREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEE 241
Query: 1195 HKKEETRRKT----EEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQ 1250
+KE +R+T EEE+ ++E+ + +RE +E +QL+ +E + ++ Q +Q
Sbjct: 242 EEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEE----EQLRKLERQE--LRRERQEEEQ 295
Query: 1251 KKQR 1254
++QR
Sbjct: 296 QQQR 299
Score = 37.7 bits (86), Expect = 0.083
Identities = 26/108 (24%), Positives = 58/108 (53%), Gaps = 9/108 (8%)
Query: 1173 EKRLRREKETQL----RKQQLEA-EMEHKKEETRRKTEEERQKK----EDERARREFIRQ 1223
E+RL+RE+E + R+++ E E E +K++ +R EEER+++ E+E R + R+
Sbjct: 444 EQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERR 503
Query: 1224 EYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHIESPKTPIK 1271
E R++ + + + + ++Q+ + + + R+ E + +K
Sbjct: 504 EQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLK 551
Score = 37.4 bits (85), Expect = 0.11
Identities = 23/109 (21%), Positives = 55/109 (50%)
Query: 1153 FFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKKE 1212
F K++Q+ ++ R RE+E QL +Q+ + + ++++ RR+ E + +E
Sbjct: 1392 FLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEE 1451
Query: 1213 DERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRD 1261
+++ R+E R+ + L+ E+ + R + +++Q+ + RD
Sbjct: 1452 EQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERD 1500
Score = 36.6 bits (83), Expect = 0.18
Identities = 89/507 (17%), Positives = 197/507 (38%), Gaps = 62/507 (12%)
Query: 738 QGRDTTQLLASEMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDG 797
Q R QLL E L+ + EKRR E +++ E +Q ++ +++++
Sbjct: 898 QLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQ-------LLREE--- 947
Query: 798 ISPLREEAAGAEDEKVYTDRAKEKESQKTDGQRSKSLADIKESMENPQAKWLKSPTTPID 857
RE+ E E+ Y K+K+ Q+ + Q L + E + + +
Sbjct: 948 ----REKRRRQERERQYR---KDKKLQQKEEQL---LGEEPEKRRRQEREKKYREEEELQ 997
Query: 858 PEKQWNLASPSEETLNEGEILEYTKSIEKLNSSLHFLQQEMQRLSLQQEMLM-----QMR 912
E++ L E+ + +Y K E L++E ++ LQ+ +++
Sbjct: 998 QEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQ 1057
Query: 913 EQQSWVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSPQSSNRKSASFSV 972
+++ ++ + + ++Q + + K+ L + + P+ R+
Sbjct: 1058 QEEEQLLGEERETRRRQELERQYRKEEELQQ-------EEEQLLREEPEKRRRQERERQC 1110
Query: 973 KSQRTPRPNELKITPLNRTLTPPRSVDSLPRLRRFSPSQVPIQTRSFVCFGDDGEPQLKE 1032
+ + + E ++ L R L R + +Q ++ E + ++
Sbjct: 1111 REEEELQQEEEQL------LREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQ 1164
Query: 1033 SKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLTPNEDQ--- 1089
++ ++EEL+ + EQ +EK + E E L + +EDQ
Sbjct: 1165 ELERQYREEEELQQEE--EQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSD 1222
Query: 1090 LNQPTEPPPKPVFPPT-----APKNVNLIEVSLSDLKPPEKADVPVEKYDGESDKEQFDD 1144
L EP + +N ++ S L+ ++ ++ GE + +
Sbjct: 1223 LKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRD-RQSQQDLQHLLGEQQERDREQ 1281
Query: 1145 DQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEM-EHKKEETRRK 1203
+++ + + D LE+ ++E + + RK Q E ++ ++EE RR+
Sbjct: 1282 ERR----------RWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRR 1331
Query: 1204 TEEERQKKEDERARREFIRQEYMRRKQ 1230
E +R+ +E+E+ +E R+E R+Q
Sbjct: 1332 QETDRKFREEEQLLQE--REEQPLRRQ 1356
Score = 33.1 bits (74), Expect = 2.0
Identities = 98/532 (18%), Positives = 204/532 (38%), Gaps = 86/532 (16%)
Query: 754 RMKLEEKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGISPLREEAAGAEDEKV 813
R + E+K R E +++ E ++R+K R + +KK D + E+ E EK
Sbjct: 983 RQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK-DELQQEEEQLLREEREK- 1040
Query: 814 YTDRAKEKESQKTDGQRSKSLADIKESMENPQAKWLKSPTTPIDPEKQWNLASPSEETLN 873
R +E+E Q + + L +E + + + + K+ L E+ L
Sbjct: 1041 --RRLQERERQYRE---EEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLR 1095
Query: 874 EGEILEYTKSIEKLNSSLHFLQQEMQRLSLQ-------QEMLMQMREQQSWVISPPQ--- 923
E + E+ LQQE ++L + QE+ Q RE++ Q
Sbjct: 1096 EEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR 1155
Query: 924 PSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSPQSSNRKSASFSVKSQRTPRPNEL 983
P+K+ R + +Q + R + + + QR R
Sbjct: 1156 EEPEKRRRQ-ELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRY 1214
Query: 984 KITPLNRTLTPPRSVDSLPRLR-RFSPSQV-PIQTRSFVCFGDDGEP--QLKESKPKEEV 1039
R D L+ ++ P + ++ C G + E QL++S+ ++
Sbjct: 1215 ------------RDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQ 1262
Query: 1040 KKEELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLTPNEDQLNQPTEPPPK 1099
+++L+ L ++ E+E + ++ P E+QL + +
Sbjct: 1263 SQQDLQH--LLGEQQERDREQERRRWQQRDRHF------------PEEEQLEREEQK--- 1305
Query: 1100 PVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGESDKEQFDDDQKVCCGFFFKDDQ- 1158
E D K E+ + E + E + + + D+K F +++Q
Sbjct: 1306 --------------EAKRRDRKSQEEKQLLRE--EREEKRRRQETDRK-----FREEEQL 1344
Query: 1159 -KAENDMAMKRAALLEKRLRREKETQLRKQQ-----LEAEMEHKKEETRRKTEEERQK-- 1210
+ + ++R ++R R+ +E +LR Q+ LE E +++E RK +E Q+
Sbjct: 1345 LQEREEQPLRR----QERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLR 1400
Query: 1211 -KEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRD 1261
+E E+ R+ +++ +Q ++ D + Q V+++++ K + +
Sbjct: 1401 CQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEE 1452
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 51.6 bits (122), Expect = 6e-06
Identities = 133/614 (21%), Positives = 227/614 (36%), Gaps = 120/614 (19%)
Query: 756 KLEEKRRAIEAQKKKME----AAFTKQRQKMGR------TAFLTVVKKKGDGISPLREEA 805
+L+E+RR +E Q+ K E A +QRQK+ + A VKK I R
Sbjct: 174 QLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSW 233
Query: 806 AGAEDEKVYTDRAKEKESQKTDGQR-SKSLADIKESMENPQAKWLKSPTTPIDPEKQWNL 864
AGA KT G R S S ++ + +++ K L + + WN
Sbjct: 234 AGALHH--------SSPGHKTSGSRCSVSAVNLPKHVDSIINKRLSKSSATL-----WN- 279
Query: 865 ASPSEETLNEGEILEYTKSIEKLNSSLHFLQQEMQRLSLQQEMLMQMR-----EQQSW-- 917
SPS + E + + +L FL + ++L + Q R +W
Sbjct: 280 -SPSRNRSLQLSAWESSIVDRLMTPTLSFLARSRSAVTLPRNGRDQGRGCDPGRGPTWGR 338
Query: 918 ----VISPPQP------------------------SPQKQIRDFKPSKQAGLSSAIAPFS 949
+ PQP S + + P+ + G P +
Sbjct: 339 AGASLARGPQPDRTHPSAAVPVCPRSASASPLTPCSVTRSVHRCAPAGERG--ERRKPNA 396
Query: 950 SDSPRPTHPSPQSS-------------NRKSASFSVKSQRTPRPNELKITPLNR-TLTPP 995
SP P P++S N K S + + + L +P R + +
Sbjct: 397 GGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTA 456
Query: 996 RSVDSLPRLRRFSP--------SQVPIQTRSFVCFGDDGEPQLKESKPKEEVKKEELESK 1047
+ + R SP S P P+ + PK V+++E E+K
Sbjct: 457 SELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKE-EAK 515
Query: 1048 GTLEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLTPNEDQLNQPTEPPPKPVFPPTAP 1107
+ G PE+K ++ + + P + P+ PT PP+ PP
Sbjct: 516 ESPSAAG--PEDKSQSKRRASNEKESAAPASPAPSPAPS------PTPAPPQKEQPPAET 567
Query: 1108 KNVNLIEVSLSDLKPPEKADVPVEKYDGESDKEQ----FDDDQKVCCGFFFKDDQ----K 1159
+ S PP P+ G +D+E+ + ++ +++Q +
Sbjct: 568 PTDAAVLTSPPAPAPPVTPSKPMA---GTTDREEATRLLAEKRRQAREQREREEQERRLQ 624
Query: 1160 AENDMAMKRAAL---LEKRLRREKETQLRKQQ---LEAEMEHKKEETRRKTEEE---RQK 1210
AE D M+ L E R RE E + R++Q +A+ E +++E +K +EE R +
Sbjct: 625 AERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSR 684
Query: 1211 KEDERARRE----FIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHIESP 1266
+E ER R E F +QE R+++ K +E++ + + R V + KQ+ S + S
Sbjct: 685 EEAERQRLEREKHFQQQEQERQERRKRLEEI--MKRTRKSEVSETKQKQDSKEANANGSS 742
Query: 1267 KTPIKGPPVSSLSL 1280
P+K S L
Sbjct: 743 PEPVKAVEARSPGL 756
Score = 40.8 bits (94), Expect = 0.010
Identities = 70/287 (24%), Positives = 109/287 (37%), Gaps = 53/287 (18%)
Query: 1025 DGEPQLKESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLT 1084
D P +K + +++ E G + R P+E ES SE S T
Sbjct: 50 DTPPAMKNATSSKQLPLEPESPSGQVGPRPAPPQE------ESPSSEAKSRGPT------ 97
Query: 1085 PNEDQLNQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGESDKEQFDD 1144
P P+ PP + V SD PP K +V + KE+ ++
Sbjct: 98 --------PPAMGPRDARPPRRSSQPSPTAVPASD-SPPTKQEVKKAGERHKLAKERREE 148
Query: 1145 DQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKT 1204
K +A K+A LEK EK LR++QL+ E RR+
Sbjct: 149 RAKY---------------LAAKKAVWLEKE---EKAKALREKQLQ--------ERRRRL 182
Query: 1205 EEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHIE 1264
EE+R K E RA E +++ + + + + + +K ++Q QR H
Sbjct: 183 EEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQ--QRWSWAGALHHS 240
Query: 1265 SPKTPIKGPPVSSLSLASLNTGDNESVHSGKRTPRSESVEGFLSPSR 1311
SP G S S++++N + KR +S S + SPSR
Sbjct: 241 SPGHKTSG---SRCSVSAVNLPKHVDSIINKRLSKS-SATLWNSPSR 283
>gi|19718731 bromodomain-containing protein 4 isoform long [Homo
sapiens]
Length = 1362
Score = 51.2 bits (121), Expect = 7e-06
Identities = 80/348 (22%), Positives = 135/348 (38%), Gaps = 55/348 (15%)
Query: 908 LMQMREQQSWVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSPQSSNRKS 967
+ Q +QQ PPQP P Q + P + L FS+ +P P Q
Sbjct: 966 VQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPM--QFSTHIQQPPPPQGQQPPHPP 1023
Query: 968 ASFSVKSQRTPRPNELKITPLNRTLTPPRSVDSLPRLR---RFSPSQVPIQTRSFVCFGD 1024
Q+ P P K + + PR S P R +PS + I + F
Sbjct: 1024 PG-----QQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQF-- 1076
Query: 1025 DGEPQLKESKPKEEV--KKEELESKGTLEQRGHNPEEKEIKPFESTVSEVL-SLPVTETV 1081
+ +S P++ V KK+EL + ++ P+ + E S ++ S P + ++
Sbjct: 1077 --QSLTHQSPPQQNVQPKKQELRAASVVQ-----PQPLVVVKEEKIHSPIIRSEPFSPSL 1129
Query: 1082 CLTP--NEDQLNQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGESDK 1139
P + + + P P +P P ++V ++PPE+ P G DK
Sbjct: 1130 RPEPPKHPESIKAPVHLPQRPEMKP--------VDVGRPVIRPPEQNAPP----PGAPDK 1177
Query: 1140 EQFDDDQKVCCGFFFKDDQKAEN----------------DMAMKRAALLEKRLRREKETQ 1183
++ + K K D K +N A + E+ R +E +
Sbjct: 1178 DKQKQEPKTPVAP--KKDLKIKNMGSWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKE 1235
Query: 1184 LRKQQLEAEMEHKKEETRRKTEEERQKKEDERARREFIR-QEYMRRKQ 1230
R++ L+A+ EH ++E R +E + +EDE A + R E RR+Q
Sbjct: 1236 EREKALKAQAEHAEKEKERLRQERMRSREDEDALEQARRAHEEARRRQ 1283
Score = 39.7 bits (91), Expect = 0.022
Identities = 24/93 (25%), Positives = 44/93 (47%)
Query: 895 QQEMQRLSLQQEMLMQMREQQSWVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPR 954
++ QRL+ QE L + EQ + + P Q P+K+ +D K K+ + +
Sbjct: 505 EERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVEENKKSK 564
Query: 955 PTHPSPQSSNRKSASFSVKSQRTPRPNELKITP 987
P P+ + + ++S S S++ P P + K P
Sbjct: 565 AKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPP 597
Score = 37.7 bits (86), Expect = 0.083
Identities = 40/176 (22%), Positives = 70/176 (39%), Gaps = 27/176 (15%)
Query: 1112 LIEVSLSDLKPPEKADVPVEKYDGESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAAL 1171
++ VS + PP K P D SD D DD + E +R A
Sbjct: 465 VVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSST--------DDSEEER---AQRLAE 513
Query: 1172 LEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKKEDERARREFIRQ-------E 1224
L+++L+ E QL A + ++ + ++K +++++KK+++ R+E + + E
Sbjct: 514 LQEQLKAVHE------QLAALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVEENKKSKAKE 567
Query: 1225 YMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHIESPKTPIKGPPVSSLSL 1280
+K K V K P +K K P + E P+ LSL
Sbjct: 568 PPPKKTKKNNSSNSNVSKKEPAPMKSK---PPPTYESEEEDKCKPMSYEEKRQLSL 620
Score = 34.3 bits (77), Expect = 0.91
Identities = 64/362 (17%), Positives = 130/362 (35%), Gaps = 30/362 (8%)
Query: 764 IEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGISPLREEAAGAEDEKVYTDRAKEKES 823
+ A +K++ F + KM VV + P + A +D + + +S
Sbjct: 439 VVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDS 498
Query: 824 QKTDGQ--RSKSLADIKESME--NPQAKWLKSPTTPIDPEKQWNLASPSEETLNEGEILE 879
D + R++ LA+++E ++ + Q L P +K+ + +E E +E
Sbjct: 499 STDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVE 558
Query: 880 YTKSIE---------KLNSSLHFLQQEMQRLSLQQEMLMQMREQQSWVISPPQPSPQKQI 930
K + K N+S + + + ++ + ++ P ++Q+
Sbjct: 559 ENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYESEEEDKCKPMSYEEKRQL 618
Query: 931 R-DFKPSKQAGLSSAIAPFSSDSPRPTHPSPQSSNRKSASFSVKSQRTPRPNELKITPLN 989
D L + S P + +P F T R E +T
Sbjct: 619 SLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIE---IDFETLKPSTLRELERYVTSCL 675
Query: 990 RTLTPPRS-----VDSLPRLRRFSPSQVPIQTRSFVCFGDDGEPQLKESKPKEEVKKEEL 1044
R P++ + +++ FS S+ + S +D E ++ PK + K
Sbjct: 676 RKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETEMA---PKSKKKGHP- 731
Query: 1045 ESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLTPNEDQLNQPTEPPPKPVFPP 1104
G +++ H+ ++++ + V + P + P + Q QP PPP P P
Sbjct: 732 ---GREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQ-QQPPPPPPPPSMPQ 787
Query: 1105 TA 1106
A
Sbjct: 788 QA 789
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 51.2 bits (121), Expect = 7e-06
Identities = 57/208 (27%), Positives = 95/208 (45%), Gaps = 55/208 (26%)
Query: 1157 DQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKKEDERA 1216
+Q+ E ++ E+ RR++E + R+++ E + ++ E RRK EEER++ E+E+
Sbjct: 400 EQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKR 459
Query: 1217 RREFIRQEYMRRK-----------QLKLMEDMDTVI----KPRPQVVKQ----KKQRPK- 1256
R E QEY+RR+ Q +L+++ ++ +P PQ +Q +++R K
Sbjct: 460 RVE-REQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKP 518
Query: 1257 SIH----RDHIE------------------SPKTPIK------GPPVSSLSLASLNTGDN 1288
S H + H E SP+ K PPV S S S + G++
Sbjct: 519 SFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRS-ESFSNGNS 577
Query: 1289 ESVHSGKRTPRSESVEGFLSPSRCGSRN 1316
ESVH + P V P R SR+
Sbjct: 578 ESVHPALQRPAEPQV-----PVRTTSRS 600
Score = 40.8 bits (94), Expect = 0.010
Identities = 26/118 (22%), Positives = 60/118 (50%), Gaps = 5/118 (4%)
Query: 1152 FFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKK 1211
F + E A++R LL+++ RE+E R+ E + ++++ +R+ EE+Q++
Sbjct: 356 FLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRR 415
Query: 1212 EDERARREFIRQEYMRRKQLKLMEDMDTVIKP-----RPQVVKQKKQRPKSIHRDHIE 1264
E E R++ Q +++ + +E+++ K R + K++ +R + R +E
Sbjct: 416 EREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLE 473
Score = 35.0 bits (79), Expect = 0.54
Identities = 37/165 (22%), Positives = 71/165 (43%), Gaps = 15/165 (9%)
Query: 1082 CLTPNEDQLNQPTEPPPKPVFPPTAPKNVNLIEVSLSD------LKPPEKADVPVEKYDG 1135
CL N Q TE K F P N + + L D K EK + E
Sbjct: 269 CLVKNYMQ-RPSTEQLLKHPFIRDQP-NERQVRIQLKDHIDRTRKKRGEKDETEYEYSGS 326
Query: 1136 ESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEME- 1194
E ++E+ + + + ++R L ++ +E+ LR+QQL E +
Sbjct: 327 EEEEEEVPEQEGEPSSIV-----NVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQL 381
Query: 1195 HKKEETRRKTEEERQKK-EDERARREFIRQEYMRRKQLKLMEDMD 1238
++EE +R+ ERQK+ E ++ +R + ++ R ++ + ++ +
Sbjct: 382 REQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQERE 426
Score = 33.1 bits (74), Expect = 2.0
Identities = 31/130 (23%), Positives = 60/130 (46%), Gaps = 8/130 (6%)
Query: 744 QLLASEMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGISPLR- 802
QLLA + + E++RR E Q+++ EA ++R++ R K++ + + R
Sbjct: 390 QLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRRE---QEEKRRLEELERRRK 446
Query: 803 --EEAAGAEDEKVYTDRAKEKESQKTDGQRSKSLADIKESMENPQAKWLKSPTTPIDPEK 860
EE AE+EK +R +E ++ + + + L +++ + QA L P P+
Sbjct: 447 EEEERRRAEEEKRRVEREQEYIRRQLE-EEQRHLEVLQQQLLQEQAMLLHDHRRP-HPQH 504
Query: 861 QWNLASPSEE 870
P +E
Sbjct: 505 SQQPPPPQQE 514
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 51.2 bits (121), Expect = 7e-06
Identities = 64/304 (21%), Positives = 135/304 (44%), Gaps = 30/304 (9%)
Query: 952 SPRPTHPSPQSSN-RKSASFSVKSQRTPRPNELKITPLNRTLTPPRSVDSLPRLRRFSPS 1010
S P+ P P S R +F QR N++ +TP + PRSV ++ F
Sbjct: 476 SKTPSSPCPASKVVRPLRTFLHTVQR----NQMLMTPTSA----PRSV-----MKSFIKR 522
Query: 1011 QVPIQTRSFVCFGDDGEPQLKESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTVS 1070
P++ F + +L+ + KEE E+L + E + EE ++K E +
Sbjct: 523 NTPLRMDPKCSFVEKERQRLENLRRKEEA--EQLRRQKVEEDKRRRLEEVKLKR-EERLR 579
Query: 1071 EVLSLPVTETVCLTPNEDQLNQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPV 1130
+VL E V +Q+ + + + F K E L++ K +KA
Sbjct: 580 KVLQ--ARERV------EQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKA--AA 629
Query: 1131 EKYDGESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLE 1190
+K + + + +++ + +++++ ++ K+ ++RLR+ E + +Q E
Sbjct: 630 KKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQRE 689
Query: 1191 AEMEHKKEETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQ 1250
E ++ + + E+ER+++E R+ QE RR+Q +L + + ++ R + ++
Sbjct: 690 QERREQERREQERREQERREQERREQERQLAEQE-RRREQERLQAERE--LQEREKALRL 746
Query: 1251 KKQR 1254
+K++
Sbjct: 747 QKEQ 750
Score = 42.7 bits (99), Expect = 0.003
Identities = 29/109 (26%), Positives = 55/109 (50%), Gaps = 14/109 (12%)
Query: 1150 CGFFFKDDQKAENDMAMKRAALLEKRLRREKET-QLRKQQLEAEMEHKKEETRRKTEEER 1208
C F K+ Q+ EN LRR++E QLR+Q++E + + EE + K EE
Sbjct: 532 CSFVEKERQRLEN-------------LRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERL 578
Query: 1209 QKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKS 1257
+K R R E +++E ++ + K + + K + + + ++K + K+
Sbjct: 579 RKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKA 627
Score = 39.7 bits (91), Expect = 0.022
Identities = 28/110 (25%), Positives = 56/110 (50%), Gaps = 5/110 (4%)
Query: 1155 KDDQKAENDMAMKRAALLEKR--LRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKKE 1212
++ Q AE + ++ L +R REK +L+K+QL+ E+E KK++ ++ ERQ +E
Sbjct: 715 QERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQE 774
Query: 1213 DERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRDH 1262
++ + ++ K L + D+ + Q+ Q + P I+ D+
Sbjct: 775 EQEKK---AKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDN 821
Score = 37.0 bits (84), Expect = 0.14
Identities = 42/165 (25%), Positives = 69/165 (41%), Gaps = 32/165 (19%)
Query: 754 RMKLEE-KRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKK--GDGISPLREEAAGAED 810
R K+EE KRR +E K K E K Q R + KKK + + E+ A++
Sbjct: 556 RQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKE 615
Query: 811 EKVYTDRAKEKESQKTDGQRSKSLADIKESMENPQAKWLKSPTTPIDPEKQWNLASPSEE 870
E++ ++AK+K + K + + A K+ E + +WL+ EE
Sbjct: 616 ERLAEEKAKKKAAAK---KMEEVEARRKQEEEARRLRWLQQ----------------EEE 656
Query: 871 TLNEGEILEYTKSIEKLNSSLHFLQQEMQRLSLQQEMLMQMREQQ 915
E+L+ K E QE R + + + L + REQ+
Sbjct: 657 ERRHQELLQKKKEEE----------QERLRKAAEAKRLAEQREQE 691
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 49.7 bits (117), Expect = 2e-05
Identities = 143/696 (20%), Positives = 252/696 (36%), Gaps = 130/696 (18%)
Query: 705 SGSSSQKTTPEGSELNIPHVVAWAQIPEETGLPQGRD-----------TTQLLASEMVHL 753
S S+ K PE L+ P +P E D TT L++S
Sbjct: 715 SPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATT 774
Query: 754 RMKLEEKRRAIEAQKKK---MEAAFTKQRQKMGRTAFLTVVKKKGDGISPLREEAAG--A 808
+ + + +A++K ++ K Q T G+ +SP +A A
Sbjct: 775 KPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPT---------GEKVSPFDSKAIPRPA 825
Query: 809 EDEKVYTDRAKEKESQKTDGQRSKSLADIKESMENPQAKWLKSPT---------TPIDPE 859
D K+ + ES+ GQ+ KE + Q K P TP P
Sbjct: 826 SDSKIISHPGPSSESK---GQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPR 882
Query: 860 KQWNLASPSEE------------TLNEGEILEYTKSIEKLNSSLHFLQQEMQRLSLQQEM 907
P+ + +LN G I + KS QE L
Sbjct: 883 PTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTT-------PQETVTGKLFGFG 935
Query: 908 LMQMREQQSWVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSPQSSNRKS 967
+ + + + QP P Q P KQA S P S P+ T +P + +
Sbjct: 936 ASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQ-PPTSQGPPKSTGQAPPAPAK-- 992
Query: 968 ASFSVKSQRTPRPNELKITPLNRTLTPPRSVDSLPRLRRFSPSQVPIQTRSFVCFGDDGE 1027
S VK + T P K+ P + P ++R + P + E
Sbjct: 993 -SIPVKKE-TKAPAAEKLEP---------KAEQAPTVKRTETEKKPPPIKDSKSL--TAE 1039
Query: 1028 PQLKESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTV---SEVLSL--------- 1075
PQ K P + K + ES L + N K+ F + ++V +L
Sbjct: 1040 PQ-KAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHL 1098
Query: 1076 -PVTETVCLTPNED-----QLNQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVP 1129
+ E +CL QL + PP P P +P V S PP+ V
Sbjct: 1099 TEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVK 1158
Query: 1130 VEKYDGESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQL 1189
++ + +++ E KV +K + ++M++ + ++++E++L K +
Sbjct: 1159 KQEQEVKTEAE------KVIL-------EKVKETLSMEKIPPMVTTDQKQEESKLEKDKA 1205
Query: 1190 EAEMEHK--KEETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDT-------- 1239
A E K EE + EEE+ + E+ ++ + ++ + KL+ + T
Sbjct: 1206 SALQEKKPLPEEKKLIPEEEKIRSEE---KKPLLEEKKPTPEDKKLLPEAKTSAPEEQKH 1262
Query: 1240 -VIKPRPQVVKQK---KQRPKSIHRDHIESPKTPIKGPPVSSLSLASLNTGDNESVHSGK 1295
++K + Q+ ++K + PK++ + P+T ++G P S + SL D+++ + K
Sbjct: 1263 DLLKSQVQIAEEKLEGRVAPKTVQEG--KQPQTKMEGLP--SGTPQSLPKEDDKTTKTIK 1318
Query: 1296 RTPRSESVEGFLSPSRC--GSRNGEKDWENASTTSS 1329
P+ P + G EK+ + + T+SS
Sbjct: 1319 EQPQPPCT---AKPDQVEPGKEKTEKEDDKSDTSSS 1351
Score = 38.9 bits (89), Expect = 0.037
Identities = 58/252 (23%), Positives = 97/252 (38%), Gaps = 33/252 (13%)
Query: 727 WAQIPEETGLPQGRDTTQLLASEMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQKMGRTA 786
W P E+ L G + L +VH R + + + I+ K M F R K+ R +
Sbjct: 4444 WFDKPRESRLENGHGLDRKLPERLVHSRPLSQHQEQIIQMNGKTMHYIFPHARIKITRDS 4503
Query: 787 FLTVVKKKGDGIS-------PLREEAAGAEDEKVYTDRAKEKESQKTDGQR--------- 830
V G GI P GA K+ + E+ + +G +
Sbjct: 4504 KDHTVSGNGLGIRIVGGKEIPGHSGEIGAYIAKILPGGSAEQTGKLMEGMQVLEWNGIPL 4563
Query: 831 -SKSLADIKESMENPQAKWLKSPTTPIDPEKQWNLASPSEETLNEGEILEYTKSIEKLNS 889
SK+ +++ + +S I N+ S SE + E+ E K+++K S
Sbjct: 4564 TSKTYEEVQSIISQ------QSGEAEICVRLDLNMLSDSENS-QHLELHEPPKAVDKAKS 4616
Query: 890 ---SLHFLQQEMQRLSLQQE--MLMQMREQQSWVISPPQPSPQKQIRDFKPSKQAGLSSA 944
L E+Q++SLQQ +L + E+ S V S P + + PS S +
Sbjct: 4617 PGVDPKQLAAELQKVSLQQSPLVLSSVVEKGSHVHSGPTSAGSSSV----PSPGQPGSPS 4672
Query: 945 IAPFSSDSPRPT 956
++ S +PT
Sbjct: 4673 VSKKKHGSSKPT 4684
Score = 35.4 bits (80), Expect = 0.41
Identities = 73/447 (16%), Positives = 165/447 (36%), Gaps = 82/447 (18%)
Query: 850 KSPTTPIDPEKQWNLASPSEETLNEGEILEYTKSIEKLNSSLHFLQQEMQRLSLQQEMLM 909
K P P P K + P+E + + + K ++K Q++ + ++ +L
Sbjct: 1124 KMPPAPSGP-KASPMPVPTESSSQKTAVPPQVKLVKK--------QEQEVKTEAEKVILE 1174
Query: 910 QMREQQSWVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSPQSSNRKSAS 969
+++E S PP + ++ + K K + P P K S
Sbjct: 1175 KVKETLSMEKIPPMVTTDQKQEESKLEKDKA-----SALQEKKPLPEEKKLIPEEEKIRS 1229
Query: 970 FSVK---SQRTPRPNELKITPLNRTLTPPRSVDSLPRLR----------RFSPSQV---- 1012
K ++ P P + K+ P +T P L + + R +P V
Sbjct: 1230 EEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGK 1289
Query: 1013 ---------PIQTRSFVCFGDDGEPQLKESKP--------------KEEVKKEELESKGT 1049
P T + DD + + +P KE+ +KE+ +S +
Sbjct: 1290 QPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTS 1349
Query: 1050 LEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLTPNEDQ--LNQPTEPPPKPVFPPTAP 1107
Q+ +P+ + S + +S + E L P +++ L + P++P
Sbjct: 1350 SSQQPKSPQGLSDTGYSS---DGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSP 1406
Query: 1108 KNVNLIEVSLSDLKPPEKADVPVEKYDGESDKEQFDDDQKVCCGFFFKDDQKAENDMAMK 1167
++ +E ++ + + + + EK + ++ + +Q KD +K ++
Sbjct: 1407 SDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQP-------KDQEKTQS----- 1454
Query: 1168 RAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKKEDERARREFIRQEYMR 1227
L E + +++++ E +K+ ++ ++++ +D + + EF+ R
Sbjct: 1455 --------LSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTR 1506
Query: 1228 RKQLKLMEDMDTVIKPRPQVVKQKKQR 1254
R+ +E+ + V Q+K+R
Sbjct: 1507 REPYDSVEESS---ESENSPVPQRKRR 1530
Score = 35.4 bits (80), Expect = 0.41
Identities = 41/208 (19%), Positives = 88/208 (42%), Gaps = 28/208 (13%)
Query: 1065 FESTVSEVLSLPVTETVCLTPNEDQLNQPTEPPPKPVFPPTAPKNVNL----IEVSLS-- 1118
F +TV ++ + + V P ++P P+ F T ++ I++S S
Sbjct: 3111 FSTTVRDLSGIHTADAVTSLPAMHH----SQPMPRSYFITTGASETDIAVTGIDISASLQ 3166
Query: 1119 -----DLKPPEKADVPVEKYDGESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLE 1173
L VP E E D+ + ++ K + + ++R L
Sbjct: 3167 TITMESLTAETIDSVPTLTTASEVFPEVVGDESAL---LIVPEEDKQQQQLDLERELLEL 3223
Query: 1174 KRLRREK---ETQLRKQQLEAEMEHKKEETRRKTEEERQKK-------EDERARREFIRQ 1223
+++++++ E + +Q+++ E +K ++K EE + K E+ER + +RQ
Sbjct: 3224 EKIKQQRFAEELEWERQEIQRFREQEKIMVQKKLEELQSMKQHLLFQQEEERQAQFMMRQ 3283
Query: 1224 EYMRRKQLKLMEDMDTVIKPRPQVVKQK 1251
E + ++QL+L + + Q+ +QK
Sbjct: 3284 ETLAQQQLQLEQIQQLQQQLHQQLEEQK 3311
Score = 34.7 bits (78), Expect = 0.70
Identities = 62/249 (24%), Positives = 95/249 (38%), Gaps = 34/249 (13%)
Query: 921 PPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSPQSSNRK-SASFSVKSQRTPR 979
P +PSPQ+ PS+Q G + S+ P P PS Q S + S + S K + P
Sbjct: 516 PAKPSPQQPGSTKPPSQQPGSAKP----SAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPT 571
Query: 980 PNELKITP----LNRTLTPPRSVDSL----PRLRRFSPSQVPIQTRSFVCFGDDGEPQLK 1031
+ P L +T+ P + L P F+ T +C G + P L
Sbjct: 572 VSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLC-GFNPNPHLT 630
Query: 1032 ESKPKEEVKKEELES-KGTLEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLTPNED-- 1088
E K + + + G L +P+ K +K T + +S + +P +D
Sbjct: 631 EVKEWLCLNCQMKRALGGDLAPVPSSPQPK-LKTAPVTTTSAVSKSSPQPQQTSPKKDAA 689
Query: 1089 ------QLNQPTEPPPKPVFP-----PTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGES 1137
+ +P +PPP P P+A SLS PP++ VP E
Sbjct: 690 PKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVP-----SEQ 744
Query: 1138 DKEQFDDDQ 1146
DK DD+
Sbjct: 745 DKAPVADDK 753
Score = 33.9 bits (76), Expect = 1.2
Identities = 52/238 (21%), Positives = 86/238 (36%), Gaps = 45/238 (18%)
Query: 952 SPRPTHPSPQSSNRKSASFSVKSQRTPRPNELKITPLNRTLTPPRSVDSLPRLRRFSPSQ 1011
+P P+ P P+ + S S+ +P+P + T + P + + P P +
Sbjct: 651 APVPSSPQPKLKTAPVTTTSAVSKSSPQPQQ---TSPKKDAAPKQDLSKAP-----EPKK 702
Query: 1012 VPIQTRSFVCFGD---------DGEPQLKESKPKEEVKKEELESKGTLEQRGHNPEEKEI 1062
P + G + + K + PKE E + + + P K +
Sbjct: 703 PPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQP--KMV 760
Query: 1063 KPFESTVSEVLSLPVTETVCLTPNEDQLNQPTEPP-------PKPVFPPTAPKNVNLIEV 1115
KP VS S + + + Q + T PP P FPPT K V
Sbjct: 761 KPTTDLVSS-SSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEK------V 813
Query: 1116 SLSDLK--PPEKADVPVEKYDGESD----KEQFDDDQKVCCGFFFKDDQKAENDMAMK 1167
S D K P +D + + G S ++Q D QK ++ +KA+ M+ K
Sbjct: 814 SPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKK------EEPKKAQTKMSPK 865
Score = 32.0 bits (71), Expect = 4.5
Identities = 70/328 (21%), Positives = 121/328 (36%), Gaps = 66/328 (20%)
Query: 705 SGSSSQKTTPEGSELNIPHVVAW------AQIPEETGLPQGRDTTQLLASEMVHLRMKLE 758
+GS S P G E ++ + A + GLP+G S +H + +L+
Sbjct: 29 AGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVPPAAAESPSMHRKQELD 88
Query: 759 EKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGISPLREEAAGAEDEKVYTDRA 818
++ + + RT ++K G SP ++ K TD
Sbjct: 89 SSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSP---STISLKESKSRTDLK 145
Query: 819 KEKESQKTDGQRSKSLADIKESMENPQAKWLKSPTTPIDPEKQWNLASPSEETLNEGEIL 878
+E +S G S+ A L + ++ ++ ++L S SE + E
Sbjct: 146 EEHKSSMMPGFLSEVNA-------------LSAVSSVVNKFNPFDLISDSEASQEET--- 189
Query: 879 EYTKSIEKLNSSLHFLQQEMQRLSLQQEMLMQMREQQSWVISPPQPSPQKQIRDFKPSKQ 938
TK Q+ +Q+ + E +++ QQ PP+P P++Q P +Q
Sbjct: 190 --TKK-----------QKVVQKEQGKPEGIIKPPLQQQ----PPKPIPKQQGPGRDPLQQ 232
Query: 939 AGLSSAIAPFSSDSPRPTHPSPQSSNRKSASFSVKSQRTPRPNELKITPLNRTLTPPRSV 998
G +I SS P P + + +TP+ + K+ PL R + P++
Sbjct: 233 DGTPKSI---SSQQPEKIKSQPPGTGKPIQG----PTQTPQTDHAKL-PLQRDASRPQTK 284
Query: 999 D-----------SLPRLRRFSPSQVPIQ 1015
SLP SPS+ PIQ
Sbjct: 285 QADIVRGESVKPSLP-----SPSKPPIQ 307
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 49.7 bits (117), Expect = 2e-05
Identities = 143/696 (20%), Positives = 252/696 (36%), Gaps = 130/696 (18%)
Query: 705 SGSSSQKTTPEGSELNIPHVVAWAQIPEETGLPQGRD-----------TTQLLASEMVHL 753
S S+ K PE L+ P +P E D TT L++S
Sbjct: 715 SPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATT 774
Query: 754 RMKLEEKRRAIEAQKKK---MEAAFTKQRQKMGRTAFLTVVKKKGDGISPLREEAAG--A 808
+ + + +A++K ++ K Q T G+ +SP +A A
Sbjct: 775 KPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPT---------GEKVSPFDSKAIPRPA 825
Query: 809 EDEKVYTDRAKEKESQKTDGQRSKSLADIKESMENPQAKWLKSPT---------TPIDPE 859
D K+ + ES+ GQ+ KE + Q K P TP P
Sbjct: 826 SDSKIISHPGPSSESK---GQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPR 882
Query: 860 KQWNLASPSEE------------TLNEGEILEYTKSIEKLNSSLHFLQQEMQRLSLQQEM 907
P+ + +LN G I + KS QE L
Sbjct: 883 PTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTT-------PQETVTGKLFGFG 935
Query: 908 LMQMREQQSWVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSPQSSNRKS 967
+ + + + QP P Q P KQA S P S P+ T +P + +
Sbjct: 936 ASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQ-PPTSQGPPKSTGQAPPAPAK-- 992
Query: 968 ASFSVKSQRTPRPNELKITPLNRTLTPPRSVDSLPRLRRFSPSQVPIQTRSFVCFGDDGE 1027
S VK + T P K+ P + P ++R + P + E
Sbjct: 993 -SIPVKKE-TKAPAAEKLEP---------KAEQAPTVKRTETEKKPPPIKDSKSL--TAE 1039
Query: 1028 PQLKESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTV---SEVLSL--------- 1075
PQ K P + K + ES L + N K+ F + ++V +L
Sbjct: 1040 PQ-KAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHL 1098
Query: 1076 -PVTETVCLTPNED-----QLNQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVP 1129
+ E +CL QL + PP P P +P V S PP+ V
Sbjct: 1099 TEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVK 1158
Query: 1130 VEKYDGESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQL 1189
++ + +++ E KV +K + ++M++ + ++++E++L K +
Sbjct: 1159 KQEQEVKTEAE------KVIL-------EKVKETLSMEKIPPMVTTDQKQEESKLEKDKA 1205
Query: 1190 EAEMEHK--KEETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDT-------- 1239
A E K EE + EEE+ + E+ ++ + ++ + KL+ + T
Sbjct: 1206 SALQEKKPLPEEKKLIPEEEKIRSEE---KKPLLEEKKPTPEDKKLLPEAKTSAPEEQKH 1262
Query: 1240 -VIKPRPQVVKQK---KQRPKSIHRDHIESPKTPIKGPPVSSLSLASLNTGDNESVHSGK 1295
++K + Q+ ++K + PK++ + P+T ++G P S + SL D+++ + K
Sbjct: 1263 DLLKSQVQIAEEKLEGRVAPKTVQEG--KQPQTKMEGLP--SGTPQSLPKEDDKTTKTIK 1318
Query: 1296 RTPRSESVEGFLSPSRC--GSRNGEKDWENASTTSS 1329
P+ P + G EK+ + + T+SS
Sbjct: 1319 EQPQPPCT---AKPDQVEPGKEKTEKEDDKSDTSSS 1351
Score = 38.9 bits (89), Expect = 0.037
Identities = 58/252 (23%), Positives = 97/252 (38%), Gaps = 33/252 (13%)
Query: 727 WAQIPEETGLPQGRDTTQLLASEMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQKMGRTA 786
W P E+ L G + L +VH R + + + I+ K M F R K+ R +
Sbjct: 4444 WFDKPRESRLENGHGLDRKLPERLVHSRPLSQHQEQIIQMNGKTMHYIFPHARIKITRDS 4503
Query: 787 FLTVVKKKGDGIS-------PLREEAAGAEDEKVYTDRAKEKESQKTDGQR--------- 830
V G GI P GA K+ + E+ + +G +
Sbjct: 4504 KDHTVSGNGLGIRIVGGKEIPGHSGEIGAYIAKILPGGSAEQTGKLMEGMQVLEWNGIPL 4563
Query: 831 -SKSLADIKESMENPQAKWLKSPTTPIDPEKQWNLASPSEETLNEGEILEYTKSIEKLNS 889
SK+ +++ + +S I N+ S SE + E+ E K+++K S
Sbjct: 4564 TSKTYEEVQSIISQ------QSGEAEICVRLDLNMLSDSENS-QHLELHEPPKAVDKAKS 4616
Query: 890 ---SLHFLQQEMQRLSLQQE--MLMQMREQQSWVISPPQPSPQKQIRDFKPSKQAGLSSA 944
L E+Q++SLQQ +L + E+ S V S P + + PS S +
Sbjct: 4617 PGVDPKQLAAELQKVSLQQSPLVLSSVVEKGSHVHSGPTSAGSSSV----PSPGQPGSPS 4672
Query: 945 IAPFSSDSPRPT 956
++ S +PT
Sbjct: 4673 VSKKKHGSSKPT 4684
Score = 35.4 bits (80), Expect = 0.41
Identities = 73/447 (16%), Positives = 165/447 (36%), Gaps = 82/447 (18%)
Query: 850 KSPTTPIDPEKQWNLASPSEETLNEGEILEYTKSIEKLNSSLHFLQQEMQRLSLQQEMLM 909
K P P P K + P+E + + + K ++K Q++ + ++ +L
Sbjct: 1124 KMPPAPSGP-KASPMPVPTESSSQKTAVPPQVKLVKK--------QEQEVKTEAEKVILE 1174
Query: 910 QMREQQSWVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSPQSSNRKSAS 969
+++E S PP + ++ + K K + P P K S
Sbjct: 1175 KVKETLSMEKIPPMVTTDQKQEESKLEKDKA-----SALQEKKPLPEEKKLIPEEEKIRS 1229
Query: 970 FSVK---SQRTPRPNELKITPLNRTLTPPRSVDSLPRLR----------RFSPSQV---- 1012
K ++ P P + K+ P +T P L + + R +P V
Sbjct: 1230 EEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGK 1289
Query: 1013 ---------PIQTRSFVCFGDDGEPQLKESKP--------------KEEVKKEELESKGT 1049
P T + DD + + +P KE+ +KE+ +S +
Sbjct: 1290 QPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTS 1349
Query: 1050 LEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLTPNEDQ--LNQPTEPPPKPVFPPTAP 1107
Q+ +P+ + S + +S + E L P +++ L + P++P
Sbjct: 1350 SSQQPKSPQGLSDTGYSS---DGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSP 1406
Query: 1108 KNVNLIEVSLSDLKPPEKADVPVEKYDGESDKEQFDDDQKVCCGFFFKDDQKAENDMAMK 1167
++ +E ++ + + + + EK + ++ + +Q KD +K ++
Sbjct: 1407 SDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQP-------KDQEKTQS----- 1454
Query: 1168 RAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKKEDERARREFIRQEYMR 1227
L E + +++++ E +K+ ++ ++++ +D + + EF+ R
Sbjct: 1455 --------LSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTR 1506
Query: 1228 RKQLKLMEDMDTVIKPRPQVVKQKKQR 1254
R+ +E+ + V Q+K+R
Sbjct: 1507 REPYDSVEESS---ESENSPVPQRKRR 1530
Score = 35.4 bits (80), Expect = 0.41
Identities = 41/208 (19%), Positives = 88/208 (42%), Gaps = 28/208 (13%)
Query: 1065 FESTVSEVLSLPVTETVCLTPNEDQLNQPTEPPPKPVFPPTAPKNVNL----IEVSLS-- 1118
F +TV ++ + + V P ++P P+ F T ++ I++S S
Sbjct: 3111 FSTTVRDLSGIHTADAVTSLPAMHH----SQPMPRSYFITTGASETDIAVTGIDISASLQ 3166
Query: 1119 -----DLKPPEKADVPVEKYDGESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLE 1173
L VP E E D+ + ++ K + + ++R L
Sbjct: 3167 TITMESLTAETIDSVPTLTTASEVFPEVVGDESAL---LIVPEEDKQQQQLDLERELLEL 3223
Query: 1174 KRLRREK---ETQLRKQQLEAEMEHKKEETRRKTEEERQKK-------EDERARREFIRQ 1223
+++++++ E + +Q+++ E +K ++K EE + K E+ER + +RQ
Sbjct: 3224 EKIKQQRFAEELEWERQEIQRFREQEKIMVQKKLEELQSMKQHLLFQQEEERQAQFMMRQ 3283
Query: 1224 EYMRRKQLKLMEDMDTVIKPRPQVVKQK 1251
E + ++QL+L + + Q+ +QK
Sbjct: 3284 ETLAQQQLQLEQIQQLQQQLHQQLEEQK 3311
Score = 34.7 bits (78), Expect = 0.70
Identities = 62/249 (24%), Positives = 95/249 (38%), Gaps = 34/249 (13%)
Query: 921 PPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSPQSSNRK-SASFSVKSQRTPR 979
P +PSPQ+ PS+Q G + S+ P P PS Q S + S + S K + P
Sbjct: 516 PAKPSPQQPGSTKPPSQQPGSAKP----SAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPT 571
Query: 980 PNELKITP----LNRTLTPPRSVDSL----PRLRRFSPSQVPIQTRSFVCFGDDGEPQLK 1031
+ P L +T+ P + L P F+ T +C G + P L
Sbjct: 572 VSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLC-GFNPNPHLT 630
Query: 1032 ESKPKEEVKKEELES-KGTLEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLTPNED-- 1088
E K + + + G L +P+ K +K T + +S + +P +D
Sbjct: 631 EVKEWLCLNCQMKRALGGDLAPVPSSPQPK-LKTAPVTTTSAVSKSSPQPQQTSPKKDAA 689
Query: 1089 ------QLNQPTEPPPKPVFP-----PTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGES 1137
+ +P +PPP P P+A SLS PP++ VP E
Sbjct: 690 PKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVP-----SEQ 744
Query: 1138 DKEQFDDDQ 1146
DK DD+
Sbjct: 745 DKAPVADDK 753
Score = 33.9 bits (76), Expect = 1.2
Identities = 52/238 (21%), Positives = 86/238 (36%), Gaps = 45/238 (18%)
Query: 952 SPRPTHPSPQSSNRKSASFSVKSQRTPRPNELKITPLNRTLTPPRSVDSLPRLRRFSPSQ 1011
+P P+ P P+ + S S+ +P+P + T + P + + P P +
Sbjct: 651 APVPSSPQPKLKTAPVTTTSAVSKSSPQPQQ---TSPKKDAAPKQDLSKAP-----EPKK 702
Query: 1012 VPIQTRSFVCFGD---------DGEPQLKESKPKEEVKKEELESKGTLEQRGHNPEEKEI 1062
P + G + + K + PKE E + + + P K +
Sbjct: 703 PPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQP--KMV 760
Query: 1063 KPFESTVSEVLSLPVTETVCLTPNEDQLNQPTEPP-------PKPVFPPTAPKNVNLIEV 1115
KP VS S + + + Q + T PP P FPPT K V
Sbjct: 761 KPTTDLVSS-SSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEK------V 813
Query: 1116 SLSDLK--PPEKADVPVEKYDGESD----KEQFDDDQKVCCGFFFKDDQKAENDMAMK 1167
S D K P +D + + G S ++Q D QK ++ +KA+ M+ K
Sbjct: 814 SPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKK------EEPKKAQTKMSPK 865
Score = 32.0 bits (71), Expect = 4.5
Identities = 70/328 (21%), Positives = 121/328 (36%), Gaps = 66/328 (20%)
Query: 705 SGSSSQKTTPEGSELNIPHVVAW------AQIPEETGLPQGRDTTQLLASEMVHLRMKLE 758
+GS S P G E ++ + A + GLP+G S +H + +L+
Sbjct: 29 AGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVPPAAAESPSMHRKQELD 88
Query: 759 EKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGISPLREEAAGAEDEKVYTDRA 818
++ + + RT ++K G SP ++ K TD
Sbjct: 89 SSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSP---STISLKESKSRTDLK 145
Query: 819 KEKESQKTDGQRSKSLADIKESMENPQAKWLKSPTTPIDPEKQWNLASPSEETLNEGEIL 878
+E +S G S+ A L + ++ ++ ++L S SE + E
Sbjct: 146 EEHKSSMMPGFLSEVNA-------------LSAVSSVVNKFNPFDLISDSEASQEET--- 189
Query: 879 EYTKSIEKLNSSLHFLQQEMQRLSLQQEMLMQMREQQSWVISPPQPSPQKQIRDFKPSKQ 938
TK Q+ +Q+ + E +++ QQ PP+P P++Q P +Q
Sbjct: 190 --TKK-----------QKVVQKEQGKPEGIIKPPLQQQ----PPKPIPKQQGPGRDPLQQ 232
Query: 939 AGLSSAIAPFSSDSPRPTHPSPQSSNRKSASFSVKSQRTPRPNELKITPLNRTLTPPRSV 998
G +I SS P P + + +TP+ + K+ PL R + P++
Sbjct: 233 DGTPKSI---SSQQPEKIKSQPPGTGKPIQG----PTQTPQTDHAKL-PLQRDASRPQTK 284
Query: 999 D-----------SLPRLRRFSPSQVPIQ 1015
SLP SPS+ PIQ
Sbjct: 285 QADIVRGESVKPSLP-----SPSKPPIQ 307
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 48.5 bits (114), Expect = 5e-05
Identities = 56/251 (22%), Positives = 106/251 (42%), Gaps = 33/251 (13%)
Query: 1035 PKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLTPNEDQLNQPT 1094
P + V+KE E + + H + +++ E + + TET P+ + P+
Sbjct: 553 PSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTET---KPSVTEKEVPS 609
Query: 1095 EPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGESDKEQFDDDQKVCCGFFF 1154
+ P PV A K +D+KP + V+K + KV
Sbjct: 610 KEEPSPVKAEVAEKQA-------TDVKPKAAKEKTVKK------------ETKVK----- 645
Query: 1155 KDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEM--EHKKEETRRKTEEERQKKE 1212
+D+K E + K A E + +KE + +K++++ E+ E KKEE + +E +++
Sbjct: 646 PEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETP 705
Query: 1213 DERARREFIRQEYMRRKQLKLME-DMDTVIKPRPQVVKQKKQRPKSIHRDHIESPKTPIK 1271
+ ++E ++E +K++K E + IK P+ K+ + PK P K
Sbjct: 706 PKEVKKEVKKEE---KKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKK 762
Query: 1272 GPPVSSLSLAS 1282
V S+A+
Sbjct: 763 EESVKKDSVAA 773
Score = 48.5 bits (114), Expect = 5e-05
Identities = 91/454 (20%), Positives = 180/454 (39%), Gaps = 74/454 (16%)
Query: 799 SPLREEAAGAEDEKVYTDRAKEKESQKTDGQRSKSLADIKESMENPQAKWLKSPTTPIDP 858
SP++ E A + V AKEK +K + + + KE + AK K TPI
Sbjct: 614 SPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAK--KEDKTPIKK 671
Query: 859 EKQWNLASPSEETLNEGEILEYTKSIEKLNSSLHFLQQEMQRLSLQQEMLMQMREQQSWV 918
E++ P +E + + E+ + K EK ++E+++ + +E+ ++++++
Sbjct: 672 EEK-----PKKEEVKK-EVKKEIKKEEKKEP-----KKEVKKETPPKEVKKEVKKEEKKE 720
Query: 919 ISPPQPSPQKQIRDF-KPSKQAG--LSSAIAPFSSDSPRPTHPSPQSSNRKSASFSVKSQ 975
+ + P+K+I+ K +K++ LS A P + +P P + S +K + + K +
Sbjct: 721 VKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAAL---KPKVPKKEESVKKDSVAAGKPK 777
Query: 976 RTPRPNELK--------ITPLNRTLTPPRSVDSLPRLRRFSPSQVPIQTRSFVCFGDDGE 1027
+ +K + T +V + + P++ RS + +D
Sbjct: 778 EKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPED-- 835
Query: 1028 PQLKESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPVTETV---CLT 1084
+K EE+K EE++ K+IKP + + L TE V +
Sbjct: 836 ----LTKDFEELKAEEVD------------VTKDIKPQLELIEDEEKLKETEPVEAYVIQ 879
Query: 1085 PNEDQLNQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADV-PVEKYDG-------- 1135
+ P E P + + T + E + +L+P EK V +EK++
Sbjct: 880 KEREVTKGPAESPDEGI---TTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEES 936
Query: 1136 -------------ESDKEQFDDDQKVCCGFF-FKDDQKAENDMAMKRAALLEKRLRREKE 1181
E+++ + D ++ VC + E+ A A + EKR
Sbjct: 937 SETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASG 996
Query: 1182 TQLRKQQLEAEMEHKKEETRRKTEEERQKKEDER 1215
++ ++ +E + E + +E K ED R
Sbjct: 997 DDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAR 1030
Score = 43.5 bits (101), Expect = 0.002
Identities = 69/325 (21%), Positives = 124/325 (38%), Gaps = 57/325 (17%)
Query: 862 WNLASPSEETLN---EGEILEYT--KSIEKLNSSLHFLQQEMQRLS----------LQQE 906
W+ A+P+E+ + G +Y + +EKL L FL+Q + ++Q
Sbjct: 475 WHPANPAEKIIRVLFPGNSTQYNILEGLEKLKH-LDFLKQPLATQKDLTGQVPTPVVKQT 533
Query: 907 MLMQMREQQSWVISPPQPSPQKQIRDF---------------KPSKQAGLSSAIAPFSSD 951
L Q + + + +P P K +R KP K + D
Sbjct: 534 KLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMV--KKD 591
Query: 952 SPRPTHPSPQSSNRKSASFSVKSQRTPRPNELKITPLNRTLTPPRS-----VDSLPRLRR 1006
P T P + ++ V S+ P P + ++ T P++ V +++
Sbjct: 592 KPIKTETKPSVTEKE-----VPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKP 646
Query: 1007 FSPSQVPIQTRSFVCFGDDGEPQLKESKPKEEVKKEELESKGTLEQRGHNPEE------- 1059
+ + + V +D P KE KPK+E K+E++ + E++ +E
Sbjct: 647 EDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPP 706
Query: 1060 ----KEIKPFE-STVSEVLSLPVTETVCLTPNEDQLNQPTEPPPKP-VFPPTAPKNVNLI 1113
KE+K E V + P E L + + + P KP P PK +
Sbjct: 707 KEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESV 766
Query: 1114 EV-SLSDLKPPEKADVPVEKYDGES 1137
+ S++ KP EK + V K +G++
Sbjct: 767 KKDSVAAGKPKEKGKIKVIKKEGKA 791
Score = 33.9 bits (76), Expect = 1.2
Identities = 77/375 (20%), Positives = 132/375 (35%), Gaps = 64/375 (17%)
Query: 759 EKRRAIEAQKKKMEA-----AFTKQRQKMG----RTAFLTVVKKKGDGISPLREEAAGAE 809
E R E + +KMEA A + + G + FLT K+ SP RE A+
Sbjct: 1027 EDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIH 1086
Query: 810 DEKVYTDRAKEKESQKTDGQRSKSLADIKESMENPQAKWLKSPTTPIDPEKQWNLASP-- 867
DE + E + + + + S + S TP+D +++P
Sbjct: 1087 DETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMD-----EMSTPRD 1141
Query: 868 --SEETLNEG------EILEYTKSIEKLNSSLHFLQQEMQRLS-LQQEMLMQMREQQSW- 917
S+ET NE E + TK L S + ++ L+ + + + +
Sbjct: 1142 VMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDYN 1201
Query: 918 ----VISPPQPSPQKQIR------------------DFKPSKQAGLSSAIAPFSSDSPRP 955
ISPP + + D K S A S ++P S S P
Sbjct: 1202 ASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSKSPSLSP 1261
Query: 956 THPSPQSS---NRKSASFSVKSQRTPRPNELKITPLNRTLTPPRSVDSL-----PRLRRF 1007
+ PSP +S +FS+ E ++ P++ +T + L
Sbjct: 1262 SPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEVV 1321
Query: 1008 SPSQVPIQTRSFVCFGDDGEPQLKESKPKEEVKK--------EELESKGTLEQRGHNPEE 1059
SPSQ + + + P E ++K E ++K E+ +P +
Sbjct: 1322 SPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPMD 1381
Query: 1060 KEIKPFESTVSEVLS 1074
+ + ES + +VLS
Sbjct: 1382 EPVPDSESPIEKVLS 1396
Score = 33.1 bits (74), Expect = 2.0
Identities = 97/527 (18%), Positives = 185/527 (35%), Gaps = 76/527 (14%)
Query: 656 NTREALSPCPSTVSTKSQPGSSASSSSGVKMTSFAEQ--KFRKLNHTDGKSSGSSSQKTT 713
++RE+L P + +KS S + V + E+ K K +T
Sbjct: 540 DSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETK 599
Query: 714 PEGSELNIPHVVAWAQIPEETGLPQGRDTTQLLASEMVHLRMKLEEKRRAIEAQKKKMEA 773
P +E +P + + E Q D A E K +K ++ + KK E
Sbjct: 600 PSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKE------KTVKKETKVKPEDKKEEK 653
Query: 774 AFTKQRQKMGRTAFLTVVKKKGDGISPLREEAAGAEDEKVYTDRAKEKESQKTDGQRSKS 833
K+ V KK D +EE E+ K KE +K
Sbjct: 654 EKPKKE-----------VAKKEDKTPIKKEEKPKKEEVK--------KEVKK-------- 686
Query: 834 LADIKESMENPQAKWLKSPTTPIDPEKQWNLASPSEETLNEGEILEYTKSIEK-LNSSLH 892
+IK+ + K +K T P + +K+ E E E + K + K S
Sbjct: 687 --EIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSST 744
Query: 893 FLQQEMQRLSLQQEMLMQMREQQSWVISPPQPSPQKQIRDFKPSKQAGLS---------- 942
L + + +L+ ++ + + ++ +P + +I+ K +A +
Sbjct: 745 PLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGAT 804
Query: 943 ----------SAIAPFSS-DSPRPTHPSPQSSNR-----KSASFSVKSQRTPRPNELKIT 986
+AI P ++ R SP+ + K+ V P +L++
Sbjct: 805 TAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKP---QLELI 861
Query: 987 PLNRTLTPPRSVDSLPRLRRFSPSQVPIQTRSFVCFGDDGEPQLKESKPK-EEVKKEELE 1045
L V++ + ++ P ++ +GE + +++ + E V+K+ ++
Sbjct: 862 EDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVD 921
Query: 1046 SKGTLEQRGHNPEEKE-----IKPFESTVSEVLSLPVTETVCLTPNEDQLNQPTEPPPKP 1100
E G EE + E+ +E E VC++ ++ + PTE
Sbjct: 922 DIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASK---HSPTEDEESA 978
Query: 1101 VFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGESDKEQFDDDQK 1147
A V+ D + E D +EK + E +E+ D++ K
Sbjct: 979 KAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDK 1025
>gi|171460958 nucleolar protein 10 [Homo sapiens]
Length = 688
Score = 48.5 bits (114), Expect = 5e-05
Identities = 30/103 (29%), Positives = 59/103 (57%), Gaps = 7/103 (6%)
Query: 1154 FKDDQKAE-----NDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKE--ETRRKTEE 1206
F+ D+++E N + K + +K+LR ++ +LR+++ E E E K E+ +++
Sbjct: 494 FQVDEESEEFRLLNPLVSKISEKRKKKLRLLEQQELREKEEEEEPEGKPSDAESSESSDD 553
Query: 1207 ERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVK 1249
E+ E+ R +R ++QE ++Q +L ED TV+KP+ +K
Sbjct: 554 EKAWVEEVRKQRRLLQQEEKVKRQERLKEDQQTVLKPQFYEIK 596
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.128 0.365
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,571,702
Number of Sequences: 37866
Number of extensions: 3117352
Number of successful extensions: 27758
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 301
Number of HSP's successfully gapped in prelim test: 751
Number of HSP's that attempted gapping in prelim test: 16559
Number of HSP's gapped (non-prelim): 7242
length of query: 1478
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1363
effective length of database: 13,892,928
effective search space: 18936060864
effective search space used: 18936060864
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.