Search of human proteins with 126362947

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|126362947 sodium channel, voltage-gated, type III, alpha
isoform 2 [Homo sapiens]
         (1951 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|126362947 sodium channel, voltage-gated, type III, alpha isof...  3891   0.0  
gi|126362955 sodium channel, voltage-gated, type III, alpha isof...  3888   0.0  
gi|126362949 sodium channel, voltage-gated, type III, alpha isof...  3868   0.0  
gi|93141212 sodium channel, voltage-gated, type II, alpha isofor...  3399   0.0  
gi|93141210 sodium channel, voltage-gated, type II, alpha isofor...  3399   0.0  
gi|93141214 sodium channel, voltage-gated, type II, alpha isofor...  3397   0.0  
gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo ...  3263   0.0  
gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s...  2943   0.0  
gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo...  2845   0.0  
gi|237512982 voltage-gated sodium channel type V alpha isoform f...  2399   0.0  
gi|30089970 voltage-gated sodium channel type V alpha isoform b ...  2383   0.0  
gi|37622907 voltage-gated sodium channel type V alpha isoform a ...  2382   0.0  
gi|150417967 voltage-gated sodium channel type V alpha isoform c...  2377   0.0  
gi|150417969 voltage-gated sodium channel type V alpha isoform d...  2331   0.0  
gi|237512980 voltage-gated sodium channel type V alpha isoform e...  2311   0.0  
gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo ...  2110   0.0  
gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapi...  1817   0.0  
gi|111378393 sodium channel, voltage-gated, type VII, alpha [Hom...  1306   0.0  
gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo...  1292   0.0  
gi|239748090 PREDICTED: similar to sodium channel, voltage-gated...  1011   0.0  
gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I...   343   7e-94
gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I...   343   7e-94
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H...   338   4e-92
gi|192807298 calcium channel, voltage-dependent, L type, alpha 1...   333   7e-91
gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H...   333   7e-91
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i...   333   1e-90
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i...   333   1e-90
gi|38505276 voltage-dependent calcium channel alpha 1G subunit i...   333   1e-90
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i...   333   1e-90
gi|38505272 voltage-dependent calcium channel alpha 1G subunit i...   333   1e-90

>gi|126362947 sodium channel, voltage-gated, type III, alpha isoform 2
            [Homo sapiens]
          Length = 1951

 Score = 3891 bits (10090), Expect = 0.0
 Identities = 1951/1951 (100%), Positives = 1951/1951 (100%)

Query: 1    MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKN 60
            MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKN
Sbjct: 1    MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKN 60

Query: 61   LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKI 120
            LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKI
Sbjct: 61   LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKI 120

Query: 121  AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCL 180
            AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCL
Sbjct: 121  AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCL 180

Query: 181  EDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240
            EDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL
Sbjct: 181  EDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240

Query: 241  IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMD 300
            IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMD
Sbjct: 241  IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMD 300

Query: 301  SNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPN 360
            SNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPN
Sbjct: 301  SNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPN 360

Query: 361  YGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLIL 420
            YGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLIL
Sbjct: 361  YGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLIL 420

Query: 421  AVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGE 480
            AVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGE
Sbjct: 421  AVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGE 480

Query: 481  LLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFS 540
            LLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFS
Sbjct: 481  LLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFS 540

Query: 541  MDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHST 600
            MDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHST
Sbjct: 541  MDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHST 600

Query: 601  FEDSESRRDSLFVPHRHGERRNSNGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIA 660
            FEDSESRRDSLFVPHRHGERRNSNGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIA
Sbjct: 601  FEDSESRRDSLFVPHRHGERRNSNGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIA 660

Query: 661  SILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITIC 720
            SILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITIC
Sbjct: 661  SILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITIC 720

Query: 721  IVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDG 780
            IVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDG
Sbjct: 721  IVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDG 780

Query: 781  IIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 840
            IIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL
Sbjct: 781  IIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 840

Query: 841  AIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMW 900
            AIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMW
Sbjct: 841  AIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMW 900

Query: 901  DCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVG 960
            DCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVG
Sbjct: 901  DCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVG 960

Query: 961  RMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIEISKELNYLRDGNG 1020
            RMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIEISKELNYLRDGNG
Sbjct: 961  RMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIEISKELNYLRDGNG 1020

Query: 1021 TTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEES 1080
            TTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEES
Sbjct: 1021 TTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEES 1080

Query: 1081 KEKLNATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKG 1140
            KEKLNATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKG
Sbjct: 1081 KEKLNATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKG 1140

Query: 1141 KIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTY 1200
            KIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTY
Sbjct: 1141 KIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTY 1200

Query: 1201 IFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1260
            IFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL
Sbjct: 1201 IFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1260

Query: 1261 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTT 1320
            RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTT
Sbjct: 1261 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTT 1320

Query: 1321 GNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDS 1380
            GNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDS
Sbjct: 1321 GNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDS 1380

Query: 1381 RDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1440
            RDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ
Sbjct: 1381 RDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1440

Query: 1441 KKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDD 1500
            KKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDD
Sbjct: 1441 KKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDD 1500

Query: 1501 QGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEM 1560
            QGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEM
Sbjct: 1501 QGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEM 1560

Query: 1561 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY 1620
            IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY
Sbjct: 1561 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY 1620

Query: 1621 AIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPD 1680
            AIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPD
Sbjct: 1621 AIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPD 1680

Query: 1681 TIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD 1740
            TIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD
Sbjct: 1681 TIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD 1740

Query: 1741 FEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHC 1800
            FEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHC
Sbjct: 1741 FEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHC 1800

Query: 1801 LDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQR 1860
            LDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQR
Sbjct: 1801 LDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQR 1860

Query: 1861 NFRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPS 1920
            NFRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPS
Sbjct: 1861 NFRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPS 1920

Query: 1921 YDSVTKPDKEKFEKDKPEKESKGKEVRENQK 1951
            YDSVTKPDKEKFEKDKPEKESKGKEVRENQK
Sbjct: 1921 YDSVTKPDKEKFEKDKPEKESKGKEVRENQK 1951


>gi|126362955 sodium channel, voltage-gated, type III, alpha isoform 3
            [Homo sapiens]
          Length = 1951

 Score = 3888 bits (10084), Expect = 0.0
 Identities = 1950/1951 (99%), Positives = 1950/1951 (99%)

Query: 1    MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKN 60
            MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKN
Sbjct: 1    MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKN 60

Query: 61   LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKI 120
            LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKI
Sbjct: 61   LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKI 120

Query: 121  AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCL 180
            AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCL
Sbjct: 121  AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCL 180

Query: 181  EDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240
            EDFTFLRDPWNWLDFSVIVMAYVTEFV LGNVSALRTFRVLRALKTISVIPGLKTIVGAL
Sbjct: 181  EDFTFLRDPWNWLDFSVIVMAYVTEFVSLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240

Query: 241  IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMD 300
            IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMD
Sbjct: 241  IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMD 300

Query: 301  SNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPN 360
            SNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPN
Sbjct: 301  SNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPN 360

Query: 361  YGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLIL 420
            YGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLIL
Sbjct: 361  YGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLIL 420

Query: 421  AVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGE 480
            AVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGE
Sbjct: 421  AVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGE 480

Query: 481  LLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFS 540
            LLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFS
Sbjct: 481  LLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFS 540

Query: 541  MDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHST 600
            MDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHST
Sbjct: 541  MDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHST 600

Query: 601  FEDSESRRDSLFVPHRHGERRNSNGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIA 660
            FEDSESRRDSLFVPHRHGERRNSNGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIA
Sbjct: 601  FEDSESRRDSLFVPHRHGERRNSNGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIA 660

Query: 661  SILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITIC 720
            SILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITIC
Sbjct: 661  SILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITIC 720

Query: 721  IVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDG 780
            IVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDG
Sbjct: 721  IVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDG 780

Query: 781  IIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 840
            IIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL
Sbjct: 781  IIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 840

Query: 841  AIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMW 900
            AIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMW
Sbjct: 841  AIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMW 900

Query: 901  DCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVG 960
            DCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVG
Sbjct: 901  DCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVG 960

Query: 961  RMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIEISKELNYLRDGNG 1020
            RMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIEISKELNYLRDGNG
Sbjct: 961  RMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIEISKELNYLRDGNG 1020

Query: 1021 TTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEES 1080
            TTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEES
Sbjct: 1021 TTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEES 1080

Query: 1081 KEKLNATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKG 1140
            KEKLNATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKG
Sbjct: 1081 KEKLNATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKG 1140

Query: 1141 KIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTY 1200
            KIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTY
Sbjct: 1141 KIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTY 1200

Query: 1201 IFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1260
            IFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL
Sbjct: 1201 IFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1260

Query: 1261 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTT 1320
            RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTT
Sbjct: 1261 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTT 1320

Query: 1321 GNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDS 1380
            GNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDS
Sbjct: 1321 GNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDS 1380

Query: 1381 RDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1440
            RDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ
Sbjct: 1381 RDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1440

Query: 1441 KKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDD 1500
            KKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDD
Sbjct: 1441 KKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDD 1500

Query: 1501 QGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEM 1560
            QGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEM
Sbjct: 1501 QGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEM 1560

Query: 1561 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY 1620
            IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY
Sbjct: 1561 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY 1620

Query: 1621 AIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPD 1680
            AIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPD
Sbjct: 1621 AIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPD 1680

Query: 1681 TIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD 1740
            TIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD
Sbjct: 1681 TIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD 1740

Query: 1741 FEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHC 1800
            FEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHC
Sbjct: 1741 FEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHC 1800

Query: 1801 LDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQR 1860
            LDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQR
Sbjct: 1801 LDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQR 1860

Query: 1861 NFRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPS 1920
            NFRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPS
Sbjct: 1861 NFRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPS 1920

Query: 1921 YDSVTKPDKEKFEKDKPEKESKGKEVRENQK 1951
            YDSVTKPDKEKFEKDKPEKESKGKEVRENQK
Sbjct: 1921 YDSVTKPDKEKFEKDKPEKESKGKEVRENQK 1951


>gi|126362949 sodium channel, voltage-gated, type III, alpha isoform 1
            [Homo sapiens]
          Length = 2000

 Score = 3868 bits (10030), Expect = 0.0
 Identities = 1951/2000 (97%), Positives = 1951/2000 (97%), Gaps = 49/2000 (2%)

Query: 1    MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKN 60
            MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKN
Sbjct: 1    MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKN 60

Query: 61   LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKI 120
            LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKI
Sbjct: 61   LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKI 120

Query: 121  AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCL 180
            AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCL
Sbjct: 121  AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCL 180

Query: 181  EDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240
            EDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL
Sbjct: 181  EDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240

Query: 241  IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMD 300
            IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMD
Sbjct: 241  IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMD 300

Query: 301  SNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPN 360
            SNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPN
Sbjct: 301  SNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPN 360

Query: 361  YGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLIL 420
            YGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLIL
Sbjct: 361  YGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLIL 420

Query: 421  AVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGE 480
            AVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGE
Sbjct: 421  AVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGE 480

Query: 481  LLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFS 540
            LLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFS
Sbjct: 481  LLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFS 540

Query: 541  MDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHST 600
            MDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHST
Sbjct: 541  MDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHST 600

Query: 601  FEDSESRRDSLFVPHRHGERRNSN------------------------------------ 624
            FEDSESRRDSLFVPHRHGERRNSN                                    
Sbjct: 601  FEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVGGP 660

Query: 625  -------------GTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELE 671
                         GTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELE
Sbjct: 661  SALTSPTGQLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELE 720

Query: 672  ESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAME 731
            ESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAME
Sbjct: 721  ESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAME 780

Query: 732  HYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELG 791
            HYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELG
Sbjct: 781  HYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELG 840

Query: 792  LSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG 851
            LSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG
Sbjct: 841  LSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG 900

Query: 852  MQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC 911
            MQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC
Sbjct: 901  MQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC 960

Query: 912  LIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKN 971
            LIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKN
Sbjct: 961  LIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKN 1020

Query: 972  KMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSV 1031
            KMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSV
Sbjct: 1021 KMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSV 1080

Query: 1032 EKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSE 1091
            EKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSE
Sbjct: 1081 EKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSE 1140

Query: 1092 GSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCY 1151
            GSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCY
Sbjct: 1141 GSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCY 1200

Query: 1152 SIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWV 1211
            SIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWV
Sbjct: 1201 SIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWV 1260

Query: 1212 AYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEG 1271
            AYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEG
Sbjct: 1261 AYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEG 1320

Query: 1272 MRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNN 1331
            MRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNN
Sbjct: 1321 MRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNN 1380

Query: 1332 LSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEE 1391
            LSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEE
Sbjct: 1381 LSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEE 1440

Query: 1392 NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLG 1451
            NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLG
Sbjct: 1441 NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLG 1500

Query: 1452 SKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSR 1511
            SKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSR
Sbjct: 1501 SKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSR 1560

Query: 1512 INLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLF 1571
            INLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLF
Sbjct: 1561 INLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLF 1620

Query: 1572 RVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYV 1631
            RVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYV
Sbjct: 1621 RVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYV 1680

Query: 1632 KKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGD 1691
            KKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGD
Sbjct: 1681 KKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGD 1740

Query: 1692 CGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKF 1751
            CGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKF
Sbjct: 1741 CGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKF 1800

Query: 1752 DPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRV 1811
            DPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRV
Sbjct: 1801 DPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRV 1860

Query: 1812 LGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRL 1871
            LGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRL
Sbjct: 1861 LGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRL 1920

Query: 1872 KNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYDSVTKPDKEK 1931
            KNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYDSVTKPDKEK
Sbjct: 1921 KNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYDSVTKPDKEK 1980

Query: 1932 FEKDKPEKESKGKEVRENQK 1951
            FEKDKPEKESKGKEVRENQK
Sbjct: 1981 FEKDKPEKESKGKEVRENQK 2000


>gi|93141212 sodium channel, voltage-gated, type II, alpha isoform 1
            [Homo sapiens]
          Length = 2005

 Score = 3399 bits (8813), Expect = 0.0
 Identities = 1712/2009 (85%), Positives = 1824/2009 (90%), Gaps = 62/2009 (3%)

Query: 1    MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQ-DNDDENKPKPNSDLEAGK 59
            MAQ++LVPPGP+SFR FTRESLAAIE+R AEEKAK+PK+E+ D DDEN PKPNSDLEAGK
Sbjct: 1    MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60

Query: 60   NLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRK 119
            +LPFIYGDIPPEMVS PLEDLDPYYINKKTFIV+NKGKAI RFSAT ALYILTP NP+RK
Sbjct: 61   SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120

Query: 120  IAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 179
            +AIKILVHSLF+MLIMCTILTNCVFMT+SNPPDWTKNVEYTFTGIYTFESLIKILARGFC
Sbjct: 121  LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180

Query: 180  LEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 239
            LEDFTFLRDPWNWLDF+VI  AYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA
Sbjct: 181  LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240

Query: 240  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTM 299
            LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP +S+FE N TS+FN ++
Sbjct: 241  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300

Query: 300  DSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNP 359
            D NGT  N T+S FNW +YI D SHFY L+GQ D LLCGN SDAGQCPEGYICVKAGRNP
Sbjct: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360

Query: 360  NYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLI 419
            NYGYTSFDTFSWAFLSLFRLMTQD+WENLYQLTLRAAGKTYMIFFVLVIFLGSFYL+NLI
Sbjct: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420

Query: 420  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAA-SAASRDFSGIGGL 478
            LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQA AAA SA SRDFSG GG+
Sbjct: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480

Query: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538
            G   ESSS ASKLSSKS KE +NRRKK++Q+E  +   + + D   KSESEDS++R  F 
Sbjct: 481  GVFSESSSVASKLSSKSEKELKNRRKKKKQKE--QSGEEEKNDRVRKSESEDSIRRKGFR 538

Query: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598
            FS++G+RLT +K+F SPHQSLLSIRGSLFSPRRNS+ S+FSFRGRAKD+GSENDFADDEH
Sbjct: 539  FSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEH 598

Query: 599  STFEDSESRRDSLFVPHRHGERRNSN---------------------------------- 624
            STFED++SRRDSLFVPHRHGERR+SN                                  
Sbjct: 599  STFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG 658

Query: 625  --------------GTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEEL 670
                          GTTTETE+RKRR SSY +SM++LED + RQRA+SIASILTNTMEEL
Sbjct: 659  GPSTLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEEL 718

Query: 671  EESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAM 730
            EESRQKCPPCWY+FAN+ LIWDCC  WLKVKHLVNL+VMDPFVDLAITICIVLNTLFMAM
Sbjct: 719  EESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAM 778

Query: 731  EHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMEL 790
            EHYPMTEQFSSVL+VGNLVFTGIFTAEM LKIIAMDPYYYFQEGWNIFDG IVSLSLMEL
Sbjct: 779  EHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMEL 838

Query: 791  GLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVV 850
            GL+NVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVV
Sbjct: 839  GLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVV 898

Query: 851  GMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTM 910
            GMQLFGKSYKECVCKI++DC LPRWHM+DFFHSFLIVFRVLCGEWIETMWDCMEVAGQTM
Sbjct: 899  GMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTM 958

Query: 911  CLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVK 970
            CL VFM+VMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGID+VK
Sbjct: 959  CLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVK 1018

Query: 971  NKMRECFQKAFFRKPKVIEIHE-----GNKIDSCMSNNTGIEISKELNYLRDGNGTTSGV 1025
             K+RE  QKAF RK K ++  +      NK DSC+SN+T IEI K+LNYL+DGNGTTSG+
Sbjct: 1019 RKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGI 1078

Query: 1026 GTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLN 1085
            G  SSVEKYV+DE+DYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSES++EESKEKLN
Sbjct: 1079 G--SSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLN 1136

Query: 1086 ATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWN 1145
            ATSSSEGSTVD+  P EGEQ E EPEE L+PEACFTE C++KF  CQ+S EEGKGK+WWN
Sbjct: 1137 ATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWN 1196

Query: 1146 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1205
            LRKTCY IVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE
Sbjct: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1256

Query: 1206 MLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRA 1265
            MLLKWVAYGFQ YFTNAWCWLDFLIVDVSLVSL ANALGYSELGAIKSLRTLRALRPLRA
Sbjct: 1257 MLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRA 1316

Query: 1266 LSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFD 1325
            LSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHC+N TTG MFD
Sbjct: 1317 LSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFD 1376

Query: 1326 ISDVNNLSDCQAL---GKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRD 1382
            +S VNN S+C+AL    + ARWKNVKVNFDNVG GYL+LLQVATFKGWMDIMYAAVDSR+
Sbjct: 1377 VSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRN 1436

Query: 1383 VKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKK 1442
            V+LQP YE+NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKK
Sbjct: 1437 VELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKK 1496

Query: 1443 YYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQG 1502
            YYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVT+QVFDISIMILICLNMVTMMVETDDQ 
Sbjct: 1497 YYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQS 1556

Query: 1503 KYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIE 1562
            + MT +L  INLVFIVLFTGE VLKL+SLR+YYFTIGWNIFDFVVVILSIVGMFLAE+IE
Sbjct: 1557 QEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIE 1616

Query: 1563 KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAI 1622
            KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAI
Sbjct: 1617 KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAI 1676

Query: 1623 FGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTI 1682
            FGMSNFAYVK+E GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDPD  
Sbjct: 1677 FGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKD 1736

Query: 1683 HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFE 1742
            HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFE
Sbjct: 1737 HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFE 1796

Query: 1743 MFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLD 1802
            MFYEVWEKFDPDATQFIEF+KLSDFA ALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLD
Sbjct: 1797 MFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLD 1856

Query: 1803 ILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNF 1862
            ILFAFTKRVLGESGEMDALRIQME+RFMASNPSKVSYEPITTTLKRKQEEVSA IIQR +
Sbjct: 1857 ILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAY 1916

Query: 1863 RCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYD 1922
            R YLLKQ++K +SS Y K+  K     PIK+D +IDKLN NSTPEKTD + STTSPPSYD
Sbjct: 1917 RRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYD 1976

Query: 1923 SVTKPDKEKFEKDKPEKESKGKEVRENQK 1951
            SVTKP+KEKFEKDK EKE KGK++RE++K
Sbjct: 1977 SVTKPEKEKFEKDKSEKEDKGKDIRESKK 2005


>gi|93141210 sodium channel, voltage-gated, type II, alpha isoform 1
            [Homo sapiens]
          Length = 2005

 Score = 3399 bits (8813), Expect = 0.0
 Identities = 1712/2009 (85%), Positives = 1824/2009 (90%), Gaps = 62/2009 (3%)

Query: 1    MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQ-DNDDENKPKPNSDLEAGK 59
            MAQ++LVPPGP+SFR FTRESLAAIE+R AEEKAK+PK+E+ D DDEN PKPNSDLEAGK
Sbjct: 1    MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60

Query: 60   NLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRK 119
            +LPFIYGDIPPEMVS PLEDLDPYYINKKTFIV+NKGKAI RFSAT ALYILTP NP+RK
Sbjct: 61   SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120

Query: 120  IAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 179
            +AIKILVHSLF+MLIMCTILTNCVFMT+SNPPDWTKNVEYTFTGIYTFESLIKILARGFC
Sbjct: 121  LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180

Query: 180  LEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 239
            LEDFTFLRDPWNWLDF+VI  AYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA
Sbjct: 181  LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240

Query: 240  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTM 299
            LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP +S+FE N TS+FN ++
Sbjct: 241  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300

Query: 300  DSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNP 359
            D NGT  N T+S FNW +YI D SHFY L+GQ D LLCGN SDAGQCPEGYICVKAGRNP
Sbjct: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360

Query: 360  NYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLI 419
            NYGYTSFDTFSWAFLSLFRLMTQD+WENLYQLTLRAAGKTYMIFFVLVIFLGSFYL+NLI
Sbjct: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420

Query: 420  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAA-SAASRDFSGIGGL 478
            LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQA AAA SA SRDFSG GG+
Sbjct: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480

Query: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538
            G   ESSS ASKLSSKS KE +NRRKK++Q+E  +   + + D   KSESEDS++R  F 
Sbjct: 481  GVFSESSSVASKLSSKSEKELKNRRKKKKQKE--QSGEEEKNDRVRKSESEDSIRRKGFR 538

Query: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598
            FS++G+RLT +K+F SPHQSLLSIRGSLFSPRRNS+ S+FSFRGRAKD+GSENDFADDEH
Sbjct: 539  FSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEH 598

Query: 599  STFEDSESRRDSLFVPHRHGERRNSN---------------------------------- 624
            STFED++SRRDSLFVPHRHGERR+SN                                  
Sbjct: 599  STFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG 658

Query: 625  --------------GTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEEL 670
                          GTTTETE+RKRR SSY +SM++LED + RQRA+SIASILTNTMEEL
Sbjct: 659  GPSTLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEEL 718

Query: 671  EESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAM 730
            EESRQKCPPCWY+FAN+ LIWDCC  WLKVKHLVNL+VMDPFVDLAITICIVLNTLFMAM
Sbjct: 719  EESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAM 778

Query: 731  EHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMEL 790
            EHYPMTEQFSSVL+VGNLVFTGIFTAEM LKIIAMDPYYYFQEGWNIFDG IVSLSLMEL
Sbjct: 779  EHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMEL 838

Query: 791  GLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVV 850
            GL+NVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVV
Sbjct: 839  GLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVV 898

Query: 851  GMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTM 910
            GMQLFGKSYKECVCKI++DC LPRWHM+DFFHSFLIVFRVLCGEWIETMWDCMEVAGQTM
Sbjct: 899  GMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTM 958

Query: 911  CLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVK 970
            CL VFM+VMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGID+VK
Sbjct: 959  CLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVK 1018

Query: 971  NKMRECFQKAFFRKPKVIEIHE-----GNKIDSCMSNNTGIEISKELNYLRDGNGTTSGV 1025
             K+RE  QKAF RK K ++  +      NK DSC+SN+T IEI K+LNYL+DGNGTTSG+
Sbjct: 1019 RKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGI 1078

Query: 1026 GTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLN 1085
            G  SSVEKYV+DE+DYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSES++EESKEKLN
Sbjct: 1079 G--SSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLN 1136

Query: 1086 ATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWN 1145
            ATSSSEGSTVD+  P EGEQ E EPEE L+PEACFTE C++KF  CQ+S EEGKGK+WWN
Sbjct: 1137 ATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWN 1196

Query: 1146 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1205
            LRKTCY IVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE
Sbjct: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1256

Query: 1206 MLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRA 1265
            MLLKWVAYGFQ YFTNAWCWLDFLIVDVSLVSL ANALGYSELGAIKSLRTLRALRPLRA
Sbjct: 1257 MLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRA 1316

Query: 1266 LSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFD 1325
            LSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHC+N TTG MFD
Sbjct: 1317 LSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFD 1376

Query: 1326 ISDVNNLSDCQAL---GKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRD 1382
            +S VNN S+C+AL    + ARWKNVKVNFDNVG GYL+LLQVATFKGWMDIMYAAVDSR+
Sbjct: 1377 VSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRN 1436

Query: 1383 VKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKK 1442
            V+LQP YE+NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKK
Sbjct: 1437 VELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKK 1496

Query: 1443 YYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQG 1502
            YYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVT+QVFDISIMILICLNMVTMMVETDDQ 
Sbjct: 1497 YYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQS 1556

Query: 1503 KYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIE 1562
            + MT +L  INLVFIVLFTGE VLKL+SLR+YYFTIGWNIFDFVVVILSIVGMFLAE+IE
Sbjct: 1557 QEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIE 1616

Query: 1563 KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAI 1622
            KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAI
Sbjct: 1617 KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAI 1676

Query: 1623 FGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTI 1682
            FGMSNFAYVK+E GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDPD  
Sbjct: 1677 FGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKD 1736

Query: 1683 HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFE 1742
            HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFE
Sbjct: 1737 HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFE 1796

Query: 1743 MFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLD 1802
            MFYEVWEKFDPDATQFIEF+KLSDFA ALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLD
Sbjct: 1797 MFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLD 1856

Query: 1803 ILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNF 1862
            ILFAFTKRVLGESGEMDALRIQME+RFMASNPSKVSYEPITTTLKRKQEEVSA IIQR +
Sbjct: 1857 ILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAY 1916

Query: 1863 RCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYD 1922
            R YLLKQ++K +SS Y K+  K     PIK+D +IDKLN NSTPEKTD + STTSPPSYD
Sbjct: 1917 RRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYD 1976

Query: 1923 SVTKPDKEKFEKDKPEKESKGKEVRENQK 1951
            SVTKP+KEKFEKDK EKE KGK++RE++K
Sbjct: 1977 SVTKPEKEKFEKDKSEKEDKGKDIRESKK 2005


>gi|93141214 sodium channel, voltage-gated, type II, alpha isoform 2
            [Homo sapiens]
          Length = 2005

 Score = 3397 bits (8808), Expect = 0.0
 Identities = 1711/2009 (85%), Positives = 1824/2009 (90%), Gaps = 62/2009 (3%)

Query: 1    MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQ-DNDDENKPKPNSDLEAGK 59
            MAQ++LVPPGP+SFR FTRESLAAIE+R AEEKAK+PK+E+ D DDEN PKPNSDLEAGK
Sbjct: 1    MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60

Query: 60   NLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRK 119
            +LPFIYGDIPPEMVS PLEDLDPYYINKKTFIV+NKGKAI RFSAT ALYILTP NP+RK
Sbjct: 61   SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120

Query: 120  IAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 179
            +AIKILVHSLF+MLIMCTILTNCVFMT+SNPPDWTKNVEYTFTGIYTFESLIKILARGFC
Sbjct: 121  LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180

Query: 180  LEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 239
            LEDFTFLRDPWNWLDF+VI  AYVTEFV+LGNVSALRTFRVLRALKTISVIPGLKTIVGA
Sbjct: 181  LEDFTFLRDPWNWLDFTVITFAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240

Query: 240  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTM 299
            LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP +S+FE N TS+FN ++
Sbjct: 241  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300

Query: 300  DSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNP 359
            D NGT  N T+S FNW +YI D SHFY L+GQ D LLCGN SDAGQCPEGYICVKAGRNP
Sbjct: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360

Query: 360  NYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLI 419
            NYGYTSFDTFSWAFLSLFRLMTQD+WENLYQLTLRAAGKTYMIFFVLVIFLGSFYL+NLI
Sbjct: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420

Query: 420  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAA-SAASRDFSGIGGL 478
            LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQA AAA SA SRDFSG GG+
Sbjct: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480

Query: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538
            G   ESSS ASKLSSKS KE +NRRKK++Q+E  +   + + D   KSESEDS++R  F 
Sbjct: 481  GVFSESSSVASKLSSKSEKELKNRRKKKKQKE--QSGEEEKNDRVRKSESEDSIRRKGFR 538

Query: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598
            FS++G+RLT +K+F SPHQSLLSIRGSLFSPRRNS+ S+FSFRGRAKD+GSENDFADDEH
Sbjct: 539  FSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEH 598

Query: 599  STFEDSESRRDSLFVPHRHGERRNSN---------------------------------- 624
            STFED++SRRDSLFVPHRHGERR+SN                                  
Sbjct: 599  STFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG 658

Query: 625  --------------GTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEEL 670
                          GTTTETE+RKRR SSY +SM++LED + RQRA+SIASILTNTMEEL
Sbjct: 659  GPSTLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEEL 718

Query: 671  EESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAM 730
            EESRQKCPPCWY+FAN+ LIWDCC  WLKVKHLVNL+VMDPFVDLAITICIVLNTLFMAM
Sbjct: 719  EESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAM 778

Query: 731  EHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMEL 790
            EHYPMTEQFSSVL+VGNLVFTGIFTAEM LKIIAMDPYYYFQEGWNIFDG IVSLSLMEL
Sbjct: 779  EHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMEL 838

Query: 791  GLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVV 850
            GL+NVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVV
Sbjct: 839  GLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVV 898

Query: 851  GMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTM 910
            GMQLFGKSYKECVCKI++DC LPRWHM+DFFHSFLIVFRVLCGEWIETMWDCMEVAGQTM
Sbjct: 899  GMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTM 958

Query: 911  CLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVK 970
            CL VFM+VMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGID+VK
Sbjct: 959  CLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVK 1018

Query: 971  NKMRECFQKAFFRKPKVIEIHE-----GNKIDSCMSNNTGIEISKELNYLRDGNGTTSGV 1025
             K+RE  QKAF RK K ++  +      NK DSC+SN+T IEI K+LNYL+DGNGTTSG+
Sbjct: 1019 RKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGI 1078

Query: 1026 GTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLN 1085
            G  SSVEKYV+DE+DYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSES++EESKEKLN
Sbjct: 1079 G--SSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLN 1136

Query: 1086 ATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWN 1145
            ATSSSEGSTVD+  P EGEQ E EPEE L+PEACFTE C++KF  CQ+S EEGKGK+WWN
Sbjct: 1137 ATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWN 1196

Query: 1146 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1205
            LRKTCY IVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE
Sbjct: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1256

Query: 1206 MLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRA 1265
            MLLKWVAYGFQ YFTNAWCWLDFLIVDVSLVSL ANALGYSELGAIKSLRTLRALRPLRA
Sbjct: 1257 MLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRA 1316

Query: 1266 LSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFD 1325
            LSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHC+N TTG MFD
Sbjct: 1317 LSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFD 1376

Query: 1326 ISDVNNLSDCQAL---GKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRD 1382
            +S VNN S+C+AL    + ARWKNVKVNFDNVG GYL+LLQVATFKGWMDIMYAAVDSR+
Sbjct: 1377 VSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRN 1436

Query: 1383 VKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKK 1442
            V+LQP YE+NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKK
Sbjct: 1437 VELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKK 1496

Query: 1443 YYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQG 1502
            YYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVT+QVFDISIMILICLNMVTMMVETDDQ 
Sbjct: 1497 YYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQS 1556

Query: 1503 KYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIE 1562
            + MT +L  INLVFIVLFTGE VLKL+SLR+YYFTIGWNIFDFVVVILSIVGMFLAE+IE
Sbjct: 1557 QEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIE 1616

Query: 1563 KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAI 1622
            KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAI
Sbjct: 1617 KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAI 1676

Query: 1623 FGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTI 1682
            FGMSNFAYVK+E GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDPD  
Sbjct: 1677 FGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKD 1736

Query: 1683 HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFE 1742
            HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFE
Sbjct: 1737 HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFE 1796

Query: 1743 MFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLD 1802
            MFYEVWEKFDPDATQFIEF+KLSDFA ALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLD
Sbjct: 1797 MFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLD 1856

Query: 1803 ILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNF 1862
            ILFAFTKRVLGESGEMDALRIQME+RFMASNPSKVSYEPITTTLKRKQEEVSA IIQR +
Sbjct: 1857 ILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAY 1916

Query: 1863 RCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYD 1922
            R YLLKQ++K +SS Y K+  K     PIK+D +IDKLN NSTPEKTD + STTSPPSYD
Sbjct: 1917 RRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYD 1976

Query: 1923 SVTKPDKEKFEKDKPEKESKGKEVRENQK 1951
            SVTKP+KEKFEKDK EKE KGK++RE++K
Sbjct: 1977 SVTKPEKEKFEKDKSEKEDKGKDIRESKK 2005


>gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo
            sapiens]
          Length = 1998

 Score = 3263 bits (8461), Expect = 0.0
 Identities = 1652/2005 (82%), Positives = 1789/2005 (89%), Gaps = 68/2005 (3%)

Query: 1    MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKN 60
            M Q +LVPPGP+SF  FTRESLAAIE+R AEEKAK PK ++ +DDEN PKPNSDLEAGKN
Sbjct: 1    MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKN 60

Query: 61   LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKI 120
            LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIV+NKGKAIFRFSATSALYILTP NP+RKI
Sbjct: 61   LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKI 120

Query: 121  AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCL 180
            AIKILVHSLFSMLIMCTILTNCVFMT+SNPPDWTKNVEYTFTGIYTFESLIKI+ARGFCL
Sbjct: 121  AIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCL 180

Query: 181  EDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240
            EDFTFLRDPWNWLDF+VI  AYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL
Sbjct: 181  EDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240

Query: 241  IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMD 300
            IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC+QWPP++++ E ++    N T++
Sbjct: 241  IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEK-NITVN 299

Query: 301  SNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPN 360
             NGT +N T+  F+WK YI D  + Y L+G  D LLCGN SDAGQCPEGY+CVKAGRNPN
Sbjct: 300  YNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPN 359

Query: 361  YGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLIL 420
            YGYTSFDTFSWAFLSLFRLMTQD+WENLYQLTLRAAGKTYMIFFVLVIFLGSFYL+NLIL
Sbjct: 360  YGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLIL 419

Query: 421  AVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAA--SRDFSGIGGL 478
            AVVAMAYEEQNQATLEEAEQKEAEFQQM+EQLKKQQE AQ  A A+A+  SR+ S  G L
Sbjct: 420  AVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRL 479

Query: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538
             +   SSSEASKLSSKSAKE RNRRKKR+Q+E   G  K E D F KSESEDS++R  F 
Sbjct: 480  SD---SSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDE-DEFQKSESEDSIRRKGFR 535

Query: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598
            FS++GNRLT +K++ SPHQSLLSIRGSLFSPRRNS+TS+FSFRGRAKDVGSENDFADDEH
Sbjct: 536  FSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEH 595

Query: 599  STFEDSESRRDSLFVPHRHGERRNSN---------------------------------- 624
            STFED+ESRRDSLFVP RHGERRNSN                                  
Sbjct: 596  STFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVG 655

Query: 625  ---------------GTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEE 669
                           GTTTETE+RKRR SS+ +SM+ LED S RQRA+SIASILTNT+EE
Sbjct: 656  GPSVPTSPVGQLLPEGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEE 715

Query: 670  LEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMA 729
            LEESRQKCPPCWY+F+N+FLIWDC   WLKVKH+VNL+VMDPFVDLAITICIVLNTLFMA
Sbjct: 716  LEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMA 775

Query: 730  MEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLME 789
            MEHYPMT+ F++VLTVGNLVFTGIFTAEM LKIIAMDPYYYFQEGWNIFDG IV+LSL+E
Sbjct: 776  MEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVE 835

Query: 790  LGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 849
            LGL+NVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV
Sbjct: 836  LGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 895

Query: 850  VGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQT 909
            VGMQLFGKSYK+CVCKI  DC LPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQ 
Sbjct: 896  VGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQA 955

Query: 910  MCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYV 969
            MCL VFM+VMVIGNLVVLNLFLALLLSSFS+DNLAATDDDNEMNNLQIAV RM KG+ YV
Sbjct: 956  MCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYV 1015

Query: 970  KNKMRECFQKAFFRKPKVIEIHE-----GNKIDSCMSNNTGIEISKELNYLRDGNGTTSG 1024
            K K+ E  Q++F RK K+++  +      NK DSCMSN+T  EI K+L+YL+D NGTTSG
Sbjct: 1016 KRKIYEFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTA-EIGKDLDYLKDVNGTTSG 1074

Query: 1025 VGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKL 1084
            +GTGSSVEKY+IDE+DYMSFINNPSLTVTVPIAVGESDFENLNTE+FSSES+LEESKEKL
Sbjct: 1075 IGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKL 1134

Query: 1085 N-ATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIW 1143
            N ++SSSEGSTVD+  P E EQ   EPEE L+PEACFTEGC+++F  CQ++ EEG+GK W
Sbjct: 1135 NESSSSSEGSTVDIGAPVE-EQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQW 1193

Query: 1144 WNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFI 1203
            WNLR+TC+ IVEHNWFETFIVFMILLSSGALAFEDIYI+QRKTIKTMLEYADKVFTYIFI
Sbjct: 1194 WNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFI 1253

Query: 1204 LEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPL 1263
            LEMLLKWVAYG+QTYFTNAWCWLDFLIVDVSLVSL ANALGYSELGAIKSLRTLRALRPL
Sbjct: 1254 LEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPL 1313

Query: 1264 RALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNM 1323
            RALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHC+N TTG+ 
Sbjct: 1314 RALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDR 1373

Query: 1324 FDISDVNNLSDCQAL---GKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDS 1380
            FDI DVNN +DC  L    + ARWKNVKVNFDNVG GYL+LLQVATFKGWMDIMYAAVDS
Sbjct: 1374 FDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDS 1433

Query: 1381 RDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1440
            R+V+LQP YEE+LYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ
Sbjct: 1434 RNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1493

Query: 1441 KKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDD 1500
            KKYYNAMKKLGSKKPQKPIPRP NKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDD
Sbjct: 1494 KKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDD 1553

Query: 1501 QGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEM 1560
            Q +Y+T +LSRINLVFIVLFTGE VLKL+SLRHYYFTIGWNIFDFVVVILSIVGMFLAE+
Sbjct: 1554 QSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAEL 1613

Query: 1561 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY 1620
            IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY
Sbjct: 1614 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY 1673

Query: 1621 AIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPD 1680
            AIFGMSNFAYVK+E GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDP+
Sbjct: 1674 AIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPN 1733

Query: 1681 TIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD 1740
             ++PGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD
Sbjct: 1734 KVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD 1793

Query: 1741 FEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHC 1800
            FEMFYEVWEKFDPDATQF+EF KLS FAAAL+PPL + +PNK+QLIAMDLPMVSGDRIHC
Sbjct: 1794 FEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHC 1853

Query: 1801 LDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQR 1860
            LDILFAFTKRVLGESGEMDALRIQME+RFMASNPSKVSY+PITTTLKRKQEEVSA IIQR
Sbjct: 1854 LDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQR 1913

Query: 1861 NFRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTS-PP 1919
             +R +LLK+ +K  S  YNK  IKG  +L IK+DMIID++N NS  EKTD + ST + PP
Sbjct: 1914 AYRRHLLKRTVKQASFTYNKNKIKGGANLLIKEDMIIDRINENSITEKTDLTMSTAACPP 1973

Query: 1920 SYDSVTKPDKEKFEKDKPEKESKGK 1944
            SYD VTKP  EK E++  ++++KGK
Sbjct: 1974 SYDRVTKPIVEKHEQEGKDEKAKGK 1998


>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
            sapiens]
          Length = 1977

 Score = 2943 bits (7629), Expect = 0.0
 Identities = 1492/2002 (74%), Positives = 1697/2002 (84%), Gaps = 80/2002 (3%)

Query: 4    ALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPF 63
            A+L PPGP+SF  FT++SLA IE+R AE K+K+PK+E+ +DDE  PKP+SDLEAGK LPF
Sbjct: 2    AMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLPF 61

Query: 64   IYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIK 123
            IYGDIPP MVSEPLEDLDPYY +KKTFIV+NKGK IFRF+AT ALY+L+P +P+R+I+IK
Sbjct: 62   IYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIK 121

Query: 124  ILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDF 183
            ILVHSLFSMLIMCTILTNC+FMT++NPPDWTKNVEYTFTGIYTFESL+KILARGFC+ +F
Sbjct: 122  ILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEF 181

Query: 184  TFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS 243
            TFLRDPWNWLDF VIV AY+TEFV+LGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS
Sbjct: 182  TFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS 241

Query: 244  VKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNG 303
            VKKLSDVMILTVFCLSVFALIGLQLFMGNL++KC                 F  ++++N 
Sbjct: 242  VKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKC-----------------FRNSLENNE 284

Query: 304  TFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGY 363
            T  ++  +  + +D+     +FY L+G KD LLCG  +D+GQCPEGY CVK GRNP+YGY
Sbjct: 285  TLESIMNTLESEEDF---RKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGY 341

Query: 364  TSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVV 423
            TSFDTFSWAFL+LFRLMTQDYWENLYQ TLRAAGKTYMIFFV+VIFLGSFYL+NLILAVV
Sbjct: 342  TSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVV 401

Query: 424  AMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGELLE 483
            AMAYEEQNQA +EEA+QKE EFQQML++LKK+QEEA+A+AAA+A          +G L E
Sbjct: 402  AMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMG-LSE 460

Query: 484  SSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFSMDG 543
            SSSE SKLSSKSAKE RNRRKK+ Q++   G  KG+ +   KSESEDS++R SF   ++G
Sbjct: 461  SSSETSKLSSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEG 520

Query: 544  NRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHSTFED 603
            +R   +K+  +P+QS LSIRGSLFS RR+S+TS+FSF+GR +D+GSE +FADDEHS F D
Sbjct: 521  HRRAHEKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGD 580

Query: 604  SESRRDSLFVPHRHGERRNSN--------------------------------------- 624
            +ESRR SLFVPHR  ERR+SN                                       
Sbjct: 581  NESRRGSLFVPHRPQERRSSNISQASRSPPMLPVNGKMHSAVDCNGVVSLVDGRSALMLP 640

Query: 625  -------GTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELEESRQKC 677
                   GTT +   +KRR SSY +S +ML D + RQRA+S ASILTNT+EELEESRQKC
Sbjct: 641  NGQLLPEGTTNQIH-KKRRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQKC 699

Query: 678  PPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTE 737
            PP WYRFA+ FLIW+C   W+K K  +  IVMDPFVDLAITICIVLNTLFMAMEH+PMTE
Sbjct: 700  PPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTE 759

Query: 738  QFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEG 797
            +F +VL +GNLVFTGIF AEMVLK+IAMDPY YFQ GWNIFD +IV+LSL+EL L++VEG
Sbjct: 760  EFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEG 819

Query: 798  LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK 857
            LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK
Sbjct: 820  LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK 879

Query: 858  SYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFML 917
            SYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQ MCLIV+M+
Sbjct: 880  SYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMM 939

Query: 918  VMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECF 977
            VMVIGNLVVLNLFLALLLSSFSSDNL A ++D + NNLQIAV R++KGI+YVK  +RE  
Sbjct: 940  VMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFI 999

Query: 978  QKAFFRKPKVI-EIHEGN----KIDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSVE 1032
             KAF +KPK+  EI +      K ++ +SN+T  E+SK  N+L++ +  +   G GSSV+
Sbjct: 1000 LKAFSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKDKIS---GFGSSVD 1056

Query: 1033 KYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSEG 1092
            K++++++D  SFI+NPSLTVTVPIA GESD EN+N EE SS+S+ E SK +LN +SSSE 
Sbjct: 1057 KHLMEDSDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSSSSEC 1116

Query: 1093 STVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYS 1152
            STVD  LP EGE+AE EP    +PEACFT+GC+++F  CQV+ E GKGKIWWN+RKTCY 
Sbjct: 1117 STVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYK 1176

Query: 1153 IVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVA 1212
            IVEH+WFE+FIV MILLSSGALAFEDIYIE++KTIK +LEYADK+FTYIFILEMLLKW+A
Sbjct: 1177 IVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIA 1236

Query: 1213 YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGM 1272
            YG++TYFTNAWCWLDFLIVDVSLV+LVAN LGYS+LG IKSLRTLRALRPLRALSRFEGM
Sbjct: 1237 YGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGM 1296

Query: 1273 RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNNL 1332
            RVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY C+N T G+ F  S V N 
Sbjct: 1297 RVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNR 1356

Query: 1333 SDCQAL---GKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVY 1389
            S+C AL    +  RWKN+KVNFDNVG GYL+LLQVATFKGW  IMYAAVDS +V  QP Y
Sbjct: 1357 SECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKY 1416

Query: 1390 EENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKK 1449
            E +LYMY+YFV+FIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKK
Sbjct: 1417 EYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1476

Query: 1450 LGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVL 1509
            LGSKKPQKPIPRP NK QG +FD VT Q FDISIM+LICLNMVTMMVE + Q ++MT VL
Sbjct: 1477 LGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVL 1536

Query: 1510 SRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPT 1569
              IN+VFI+LFTGE VLKL+SLRHYYFT+GWNIFDFVVVI+SIVGMFLA++IE YFVSPT
Sbjct: 1537 YWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPT 1596

Query: 1570 LFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1629
            LFRVIRLARIGRILRL+KGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA
Sbjct: 1597 LFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1656

Query: 1630 YVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVK 1689
            YVKKE GI+DMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDP  +HPGSSV+
Sbjct: 1657 YVKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVE 1716

Query: 1690 GDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWE 1749
            GDCGNPSVGIF+FVSYIIISFLVVVNMYIAVILENFSVATEES EPLSEDDFEMFYEVWE
Sbjct: 1717 GDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWE 1776

Query: 1750 KFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTK 1809
            KFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTK
Sbjct: 1777 KFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTK 1836

Query: 1810 RVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQ 1869
            RVLGESGEMD+LR QME+RFM++NPSKVSYEPITTTLKRKQE+VSA +IQR +R Y L+Q
Sbjct: 1837 RVLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQ 1896

Query: 1870 RLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYDSVTKPDK 1929
             +KNISS Y K+  +   DL  K+DM  D +N NS+PEKTD +SSTTSPPSYDSVTKPDK
Sbjct: 1897 NVKNISSIYIKDGDRDD-DLLNKKDMAFDNVNENSSPEKTDATSSTTSPPSYDSVTKPDK 1955

Query: 1930 EKFEKDKPEKESKGKEVRENQK 1951
            EK+E+D+ EKE KGK+ +E++K
Sbjct: 1956 EKYEQDRTEKEDKGKDSKESKK 1977


>gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo
            sapiens]
          Length = 1980

 Score = 2845 bits (7375), Expect = 0.0
 Identities = 1473/2025 (72%), Positives = 1666/2025 (82%), Gaps = 121/2025 (5%)

Query: 1    MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKK----EQDNDDENKPKPNSDLE 56
            MA  LL PPGP+SF+ FT ESLA IE+R AE K KKP K     +++D+++KPKPNSDLE
Sbjct: 1    MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLE 60

Query: 57   AGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNP 116
            AGK+LPFIYGDIP  +V+ PLED DPYY+ +KTF+V+N+GK +FRFSAT ALYIL+P N 
Sbjct: 61   AGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNL 120

Query: 117  VRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILAR 176
            +R+IAIKIL+HS+FSM+IMCTILTNCVFMT SNPPDW+KNVEYTFTGIYTFESL+KI+AR
Sbjct: 121  IRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIAR 180

Query: 177  GFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTI 236
            GFC++ FTFLRDPWNWLDFSVI+MAY+TEFV+LGNVSALRTFRVLRALKTISVIPGLKTI
Sbjct: 181  GFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTI 240

Query: 237  VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFN 296
            VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC+ WP +           FN
Sbjct: 241  VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPIN-----------FN 289

Query: 297  GTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAG 356
             +   NGT        F+W++YI + ++FY + G  +PLLCGN SDAGQCPEGY C+KAG
Sbjct: 290  ESYLENGT------KGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAG 343

Query: 357  RNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLV 416
            RNPNYGYTSFDTFSWAFL+LFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIF+GSFYLV
Sbjct: 344  RNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLV 403

Query: 417  NLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASR------ 470
            NLILAVVAMAYEEQNQATLEEAEQKEAEF+ MLEQLKKQQEEAQA A A++A        
Sbjct: 404  NLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAI 463

Query: 471  DFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESED 530
            +  G  G G    SSSE SKLSSKSAKE RNRRKKR+Q+E  EG  KG+ +   KSESED
Sbjct: 464  EEEGEEGGGSP-RSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESED 522

Query: 531  SVKRSSFLFSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRG--RAKDVG 588
             ++R +F   +  NR+   +KF   +QSLLSI GS F  R NSK+SIFSFRG  R +D G
Sbjct: 523  GMRRKAF--RLPDNRI--GRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPG 578

Query: 589  SENDFADDEHSTFEDSESRRDSLFVPHRHGERRNS------------------------- 623
            SEN+FADDEHST E+SE RRDSLF+P R  ERR+S                         
Sbjct: 579  SENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVK 638

Query: 624  -------NGT-------------------TTETEVRKRRLSSYQISMEMLEDSSGRQRAV 657
                   NG                    TTE E++K+   S  +SM+ L     + R  
Sbjct: 639  RNSTVDCNGVVSLIGGPGSHIGGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRIN 698

Query: 658  SIASILTNTM-EELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLA 716
            SI S++TNT+ EELEES++KCPPCWY+FAN FLIW+C   W+K+K +VNLIVMDPFVDLA
Sbjct: 699  SIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLA 758

Query: 717  ITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWN 776
            ITICIVLNTLFMAMEH+PMT QF  VL VGNLVFTGIFTAEM LK+IAMDPYYYFQEGWN
Sbjct: 759  ITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWN 818

Query: 777  IFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNL 836
            IFDG IVSLSLMEL L++VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNL
Sbjct: 819  IFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNL 878

Query: 837  TLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWI 896
            TLVLAIIVFIFAVVGMQLFGKSYKECVCKIN DC LPRWHM+DFFHSFLIVFRVLCGEWI
Sbjct: 879  TLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWI 938

Query: 897  ETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQ 956
            ETMWDCMEVAGQ MCLIVFM+VMVIGNLVVLNLFLALLLSSFS+DNLAATDDD EMNNLQ
Sbjct: 939  ETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQ 998

Query: 957  IAVGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKI----DSCMSNNTGIEISKEL 1012
            I+V R++KG+ + K K+   F +A F++ +  E+   +++     +C++N+TG +I +  
Sbjct: 999  ISVIRIKKGVAWTKLKVH-AFMQAHFKQREADEVKPLDELYEKKANCIANHTGADIHRNG 1057

Query: 1013 NYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFS 1072
            ++ ++GNGTTSG+G  SSVEKY+IDE D+MSFINNP+LTV VPIAVGESDFENLNTE+ S
Sbjct: 1058 DFQKNGNGTTSGIG--SSVEKYIIDE-DHMSFINNPNLTVRVPIAVGESDFENLNTEDVS 1114

Query: 1073 SESELEESKEKLNATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQ 1132
            SES+ E SK+KL+ TSSSEGST+D+  P   E    +PEE L P+ACFTEGC+++F  CQ
Sbjct: 1115 SESDPEGSKDKLDDTSSSEGSTIDIK-PEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQ 1173

Query: 1133 VSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLE 1192
            V+ EEG GK WW LRKTC+ IVEHNWFETFI+FMILLSSGALAFEDIYIEQRKTI+T+LE
Sbjct: 1174 VNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILE 1233

Query: 1193 YADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIK 1252
            YADKVFTYIFILEMLLKW AYGF  +FTNAWCWLDFLIV VSLVSL+ANALGYSELGAIK
Sbjct: 1234 YADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIK 1293

Query: 1253 SLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF 1312
            SLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK+
Sbjct: 1294 SLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKY 1353

Query: 1313 YHCVNMTTGNMFDISDVNNLSDCQAL----GKQARWKNVKVNFDNVGAGYLALLQVATFK 1368
            ++C N T+   F+I DVNN ++C+ L      + RWKNVK+NFDNVGAGYLALLQVATFK
Sbjct: 1354 HYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFK 1413

Query: 1369 GWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1428
            GWMDIMYAAVDSR    QP YE+N+YMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK
Sbjct: 1414 GWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1473

Query: 1429 FGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILIC 1488
            FGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG+VFDFVT+Q FDI IM+LIC
Sbjct: 1474 FGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLIC 1533

Query: 1489 LNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVV 1548
            LNMVTMMVETD Q K M  +L  INLVF++ FT E VLK+ +LRHYYFTIGWNIFDFVVV
Sbjct: 1534 LNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVV 1593

Query: 1549 ILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFN 1608
            ILSIVGMFLA++IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFN
Sbjct: 1594 ILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFN 1653

Query: 1609 IGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP 1668
            IGLLLFLVMFI++IFGMSNFAYVK EAGIDDMFNFETFGNSMICLFQITTSAGWDGLL P
Sbjct: 1654 IGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLP 1713

Query: 1669 ILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVA 1728
            ILN  PPDC  D  HPGS  KGDCGNPSVGIFFFVSYIIISFL+VVNMYIA+ILENFSVA
Sbjct: 1714 ILN-RPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVA 1772

Query: 1729 TEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAM 1788
            TEESA+PLSEDDFE FYE+WEKFDPDATQFIE+ KL+DFA AL+ PL + KPN ++LIAM
Sbjct: 1773 TEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAM 1832

Query: 1789 DLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKR 1848
            DLPMVSGDRIHCLDILFAFTKRVLG+SGE+D LR QME+RF+ASNPSKVSYEPITTTL+R
Sbjct: 1833 DLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRR 1892

Query: 1849 KQEEVSAAIIQRNFRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEK 1908
            KQEEVSA ++QR +R +L ++      +  NK                    NG +  EK
Sbjct: 1893 KQEEVSAVVLQRAYRGHLARRGFICKKTTSNKLE------------------NGGTHREK 1934

Query: 1909 TDGSSSTTSPPSYDSVTKPDKEK---FEKDKPEKESKGKEVRENQ 1950
             + + ST S PSYDSVTKP+KEK    E+ + E+  + KEVRE++
Sbjct: 1935 KESTPSTASLPSYDSVTKPEKEKQQRAEEGRRERAKRQKEVRESK 1979


>gi|237512982 voltage-gated sodium channel type V alpha isoform f
            [Homo sapiens]
          Length = 1962

 Score = 2399 bits (6218), Expect = 0.0
 Identities = 1266/2008 (63%), Positives = 1497/2008 (74%), Gaps = 157/2008 (7%)

Query: 6    LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDN----DDENKPKPNSDLEAGKNL 61
            L+P G  SFR FTRESLAAIEKR AE++A+     Q++     +E  P+P  DL+A K L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 62   PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIA 121
            P +YG+ P E++ EPLEDLDP+Y  +KTFIV+NKGK IFRFSAT+ALY+L+P +P+R+ A
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 122  IKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 181
            +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 182  DFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
             FTFLRDPWNWLDFSVI+MAYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244

Query: 242  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDS 301
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+        
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTAL------- 287

Query: 302  NGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRN 358
            NGT  +V      W+    Y+ D  ++ + +G  D LLCGN SDAG CPEGY C+KAG N
Sbjct: 288  NGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGEN 347

Query: 359  PNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNL 418
            P++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYLVNL
Sbjct: 348  PDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNL 407

Query: 419  ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGL 478
            ILAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                 I G+
Sbjct: 408  ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALT--------------IRGV 453

Query: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538
              +  SS E S L+  ++ E R++R+KR       G  +   D  PKS+SED  +  + L
Sbjct: 454  DTVSRSSLEMSPLAPVNSHERRSKRRKRMS----SGTEECGEDRLPKSDSEDGPRAMNHL 509

Query: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598
                G   TS K                    R+S+ SIF+FR R  D+GSE DFADDE+
Sbjct: 510  SLTRGLSRTSMKP-------------------RSSRGSIFTFRRR--DLGSEADFADDEN 548

Query: 599  STFEDSESRRDSLFVPHR---------------------HGERRNS---NG--------- 625
            ST  +SES   SL VP                       HG++ ++   NG         
Sbjct: 549  STAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGD 608

Query: 626  ---------------------TTTETEVR--KRRLSSYQISMEMLEDSSGRQRAVSIASI 662
                                 TTT +E     + L+S    ++  E+   RQRA+S  S+
Sbjct: 609  PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668

Query: 663  LTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIV 722
            LT+ +EELEESR KCPPCW R A  +LIW+CC  W+ +K  V L+VMDPF DL IT+CIV
Sbjct: 669  LTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIV 728

Query: 723  LNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGII 782
            LNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD II
Sbjct: 729  LNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSII 788

Query: 783  VSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 842
            V LSLMELGLS +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAI
Sbjct: 789  VILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAI 848

Query: 843  IVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDC 902
            IVFIFAVVGMQLFGK+Y E   + +D   LPRWHM DFFH+FLI+FR+LCGEWIETMWDC
Sbjct: 849  IVFIFAVVGMQLFGKNYSE--LRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDC 906

Query: 903  MEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRM 962
            MEV+GQ++CL+VF+LVMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ R+
Sbjct: 907  MEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARI 966

Query: 963  QKGIDYVKNKMRE-CFQKAFFRKPKVIEIHEGNKIDSCMSNNTG------IEISKELNYL 1015
            Q+G+ +VK    + C      R  K   +    ++ SC++           ++       
Sbjct: 967  QRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKET 1026

Query: 1016 RDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSES 1075
            R   G   G GT    E                   V VPIAV ESD ++   +E +S  
Sbjct: 1027 RFEEGEQPGQGTPGDPE------------------PVCVPIAVAESDTDDQEEDEENSLG 1068

Query: 1076 ELEESKEKLNATSSSEGSTVDVVLPREGEQAETEPEEDLK-PEACFTEGCIKKFPFCQVS 1134
              EES ++    S SEGST D+    E  +   +  +D+K PE CFTEGC+++ P C V 
Sbjct: 1069 TEEESSKQTPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVD 1128

Query: 1135 TEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYA 1194
            T +  GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEYA
Sbjct: 1129 TTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYA 1188

Query: 1195 DKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSL 1254
            DK+FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSLVAN LG++E+G IKSL
Sbjct: 1189 DKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSL 1248

Query: 1255 RTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH 1314
            RTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  
Sbjct: 1249 RTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGR 1308

Query: 1315 CVNMTTGNM-FDISDVNNLSDCQALG--KQARWKNVKVNFDNVGAGYLALLQVATFKGWM 1371
            C+N T G++  + + VNN S C++L    +  W  VKVNFDNVGAGYLALLQVATFKGWM
Sbjct: 1309 CINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWM 1368

Query: 1372 DIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGG 1431
            DIMYAAVDSR  + QP +E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GG
Sbjct: 1369 DIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGG 1428

Query: 1432 QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNM 1491
            QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VT+Q FD++IM LICLNM
Sbjct: 1429 QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNM 1488

Query: 1492 VTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILS 1551
            VTMMVETDDQ      +L++INL+F+ +FTGE ++KL +LRHYYFT  WNIFDFVVVILS
Sbjct: 1489 VTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILS 1548

Query: 1552 IVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGL 1611
            IVG  L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGL
Sbjct: 1549 IVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGL 1608

Query: 1612 LLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILN 1671
            LLFLVMFIY+IFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN
Sbjct: 1609 LLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILN 1668

Query: 1672 SAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEE 1731
            + PP CDP T+   +  +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEE
Sbjct: 1669 TGPPYCDP-TLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEE 1727

Query: 1732 SAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLP 1791
            S EPLSEDDF+MFYE+WEKFDP+ATQFIE+S LSDFA AL  PL IAKPN++ LI MDLP
Sbjct: 1728 STEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLP 1787

Query: 1792 MVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQE 1851
            MVSGDRIHC+DILFAFTKRVLGESGEMDAL+IQME++FMA+NPSK+SYEPITTTL+RK E
Sbjct: 1788 MVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHE 1847

Query: 1852 EVSAAIIQRNFRCYLLKQRLKNISSNYNKEAIKG--RIDLPIKQDMIIDKLNGNST---- 1905
            EVSA +IQR FR +LL++ LK+ S  + ++A  G    D P ++ +I   ++ N +    
Sbjct: 1848 EVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLG 1907

Query: 1906 PEKTDGSSSTTSPPSYDSVTKPDKEKFE 1933
            P  +   SST+ PPSYDSVT+   +  +
Sbjct: 1908 PPSSSSISSTSFPPSYDSVTRATSDNLQ 1935


>gi|30089970 voltage-gated sodium channel type V alpha isoform b [Homo
            sapiens]
          Length = 2015

 Score = 2383 bits (6176), Expect = 0.0
 Identities = 1273/2061 (61%), Positives = 1503/2061 (72%), Gaps = 210/2061 (10%)

Query: 6    LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDN----DDENKPKPNSDLEAGKNL 61
            L+P G  SFR FTRESLAAIEKR AE++A+     Q++     +E  P+P  DL+A K L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 62   PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIA 121
            P +YG+ P E++ EPLEDLDP+Y  +KTFIV+NKGK IFRFSAT+ALY+L+P +P+R+ A
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 122  IKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 181
            +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 182  DFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
             FTFLRDPWNWLDFSVI+MAY TEFVDLGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244

Query: 242  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDS 301
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+        
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTAL------- 287

Query: 302  NGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRN 358
            NGT  +V      W+    Y+ D  ++ + +G  D LLCGN SDAG CPEGY C+KAG N
Sbjct: 288  NGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGEN 347

Query: 359  PNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNL 418
            P++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYLVNL
Sbjct: 348  PDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNL 407

Query: 419  ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGL 478
            ILAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                 I G+
Sbjct: 408  ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALT--------------IRGV 453

Query: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538
              +  SS E S L+  ++ E R++R+KR       G  +   D  PKS+SED  +  + L
Sbjct: 454  DTVSRSSLEMSPLAPVNSHERRSKRRKRMS----SGTEECGEDRLPKSDSEDGPRAMNHL 509

Query: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598
                G   TS K                    R+S+ SIF+FR R  D+GSE DFADDE+
Sbjct: 510  SLTRGLSRTSMKP-------------------RSSRGSIFTFRRR--DLGSEADFADDEN 548

Query: 599  STFEDSESRRDSLFVPHR---------------------HGERRNS---NG--------- 625
            ST  +SES   SL VP                       HG++ ++   NG         
Sbjct: 549  STAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGD 608

Query: 626  ---------------------TTTETEVR--KRRLSSYQISMEMLEDSSGRQRAVSIASI 662
                                 TTT +E     + L+S    ++  E+   RQRA+S  S+
Sbjct: 609  PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668

Query: 663  LTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIV 722
            LT+ +EELEESR KCPPCW R A  +LIW+CC  W+ +K  V L+VMDPF DL IT+CIV
Sbjct: 669  LTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIV 728

Query: 723  LNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGII 782
            LNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD II
Sbjct: 729  LNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSII 788

Query: 783  VSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 842
            V LSLMELGLS +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAI
Sbjct: 789  VILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAI 848

Query: 843  IVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDC 902
            IVFIFAVVGMQLFGK+Y E   + +D   LPRWHM DFFH+FLI+FR+LCGEWIETMWDC
Sbjct: 849  IVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDC 906

Query: 903  MEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRM 962
            MEV+GQ++CL+VF+LVMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ R+
Sbjct: 907  MEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARI 966

Query: 963  QKGIDYVKNKMRE-CFQKAFFRKPKVIEIHEGNKIDSCMSNNTGI------EISKELNYL 1015
            Q+G+ +VK    + C      R  K   +    ++ SC++           ++       
Sbjct: 967  QRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKET 1026

Query: 1016 RDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFEN--------LN 1067
            R   G   G GT    E                   V VPIAV ESD ++        L 
Sbjct: 1027 RFEEGEQPGQGTPGDPEP------------------VCVPIAVAESDTDDQEEDEENSLG 1068

Query: 1068 TEEFSSESELE------------ESKEKLNATSSSE------------------------ 1091
            TEE SS+ E +             +  +++AT+SSE                        
Sbjct: 1069 TEEESSKQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCG 1128

Query: 1092 ---------GSTVDVVLPREGEQAETEPEEDLK-PEACFTEGCIKKFPFCQVSTEEGKGK 1141
                     GST D+    E  +   +  +D+K PE CFTEGC+++ P C V T +  GK
Sbjct: 1129 ETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGK 1188

Query: 1142 IWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYI 1201
            +WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEYADK+FTY+
Sbjct: 1189 VWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYV 1248

Query: 1202 FILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALR 1261
            F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSLVAN LG++E+G IKSLRTLRALR
Sbjct: 1249 FVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1308

Query: 1262 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTG 1321
            PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  C+N T G
Sbjct: 1309 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEG 1368

Query: 1322 NM-FDISDVNNLSDCQALGKQAR--WKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAV 1378
            ++  + + VNN S C++L       W  VKVNFDNVGAGYLALLQVATFKGWMDIMYAAV
Sbjct: 1369 DLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAV 1428

Query: 1379 DSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTE 1438
            DSR  + QP +E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTE
Sbjct: 1429 DSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTE 1488

Query: 1439 EQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVET 1498
            EQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTMMVET
Sbjct: 1489 EQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVET 1548

Query: 1499 DDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLA 1558
            DDQ      +L++INL+F+ +FTGE ++KL +LRHYYFT  WNIFDFVVVILSIVG  L+
Sbjct: 1549 DDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLS 1608

Query: 1559 EMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1618
            ++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVMF
Sbjct: 1609 DIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1668

Query: 1619 IYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCD 1678
            IY+IFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP CD
Sbjct: 1669 IYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCD 1728

Query: 1679 PDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1738
            P T+   +  +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EPLSE
Sbjct: 1729 P-TLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSE 1787

Query: 1739 DDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRI 1798
            DDF+MFYE+WEKFDP+ATQFIE+S LSDFA AL  PL IAKPN++ LI MDLPMVSGDRI
Sbjct: 1788 DDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRI 1847

Query: 1799 HCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAII 1858
            HC+DILFAFTKRVLGESGEMDAL+IQME++FMA+NPSK+SYEPITTTL+RK EEVSA +I
Sbjct: 1848 HCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVI 1907

Query: 1859 QRNFRCYLLKQRLKNISSNYNKEAIKG--RIDLPIKQDMIIDKLNGNST----PEKTDGS 1912
            QR FR +LL++ LK+ S  + ++A  G    D P ++ +I   ++ N +    P  +   
Sbjct: 1908 QRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSI 1967

Query: 1913 SSTTSPPSYDSVTKPDKEKFE 1933
            SST+ PPSYDSVT+   +  +
Sbjct: 1968 SSTSFPPSYDSVTRATSDNLQ 1988


>gi|37622907 voltage-gated sodium channel type V alpha isoform a [Homo
            sapiens]
          Length = 2016

 Score = 2382 bits (6172), Expect = 0.0
 Identities = 1271/2062 (61%), Positives = 1501/2062 (72%), Gaps = 211/2062 (10%)

Query: 6    LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDN----DDENKPKPNSDLEAGKNL 61
            L+P G  SFR FTRESLAAIEKR AE++A+     Q++     +E  P+P  DL+A K L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 62   PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIA 121
            P +YG+ P E++ EPLEDLDP+Y  +KTFIV+NKGK IFRFSAT+ALY+L+P +P+R+ A
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 122  IKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 181
            +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 182  DFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
             FTFLRDPWNWLDFSVI+MAY TEFVDLGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244

Query: 242  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDS 301
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+        
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTAL------- 287

Query: 302  NGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRN 358
            NGT  +V      W+    Y+ D  ++ + +G  D LLCGN SDAG CPEGY C+KAG N
Sbjct: 288  NGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGEN 347

Query: 359  PNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNL 418
            P++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYLVNL
Sbjct: 348  PDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNL 407

Query: 419  ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGL 478
            ILAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                 I G+
Sbjct: 408  ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALT--------------IRGV 453

Query: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538
              +  SS E S L+  ++ E R++R+KR       G  +   D  PKS+SED  +  + L
Sbjct: 454  DTVSRSSLEMSPLAPVNSHERRSKRRKRMS----SGTEECGEDRLPKSDSEDGPRAMNHL 509

Query: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598
                G   TS K                    R+S+ SIF+FR R  D+GSE DFADDE+
Sbjct: 510  SLTRGLSRTSMKP-------------------RSSRGSIFTFRRR--DLGSEADFADDEN 548

Query: 599  STFEDSESRRDSLFVPHR---------------------HGERRNS---NG--------- 625
            ST  +SES   SL VP                       HG++ ++   NG         
Sbjct: 549  STAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGD 608

Query: 626  ---------------------TTTETEVR--KRRLSSYQISMEMLEDSSGRQRAVSIASI 662
                                 TTT +E     + L+S    ++  E+   RQRA+S  S+
Sbjct: 609  PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668

Query: 663  LTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIV 722
            LT+ +EELEESR KCPPCW R A  +LIW+CC  W+ +K  V L+VMDPF DL IT+CIV
Sbjct: 669  LTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIV 728

Query: 723  LNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGII 782
            LNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD II
Sbjct: 729  LNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSII 788

Query: 783  VSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 842
            V LSLMELGLS +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAI
Sbjct: 789  VILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAI 848

Query: 843  IVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDC 902
            IVFIFAVVGMQLFGK+Y E   + +D   LPRWHM DFFH+FLI+FR+LCGEWIETMWDC
Sbjct: 849  IVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDC 906

Query: 903  MEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRM 962
            MEV+GQ++CL+VF+LVMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ R+
Sbjct: 907  MEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARI 966

Query: 963  QKGIDYVKNKMRE-CFQKAFFRKPKVIEIHEGNKIDSCMSNNTGI------EISKELNYL 1015
            Q+G+ +VK    + C      R  K   +    ++ SC++           ++       
Sbjct: 967  QRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKET 1026

Query: 1016 RDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSES 1075
            R   G   G GT    E                   V VPIAV ESD ++   +E +S  
Sbjct: 1027 RFEEGEQPGQGTPGDPEP------------------VCVPIAVAESDTDDQEEDEENSLG 1068

Query: 1076 ELEESKEK---------------------LNATSSSE----------------------- 1091
              EES ++                     ++AT+SSE                       
Sbjct: 1069 TEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGC 1128

Query: 1092 ----------GSTVDVVLPREGEQAETEPEEDLK-PEACFTEGCIKKFPFCQVSTEEGKG 1140
                      GST D+    E  +   +  +D+K PE CFTEGC+++ P C V T +  G
Sbjct: 1129 GETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPG 1188

Query: 1141 KIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTY 1200
            K+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEYADK+FTY
Sbjct: 1189 KVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTY 1248

Query: 1201 IFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1260
            +F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSLVAN LG++E+G IKSLRTLRAL
Sbjct: 1249 VFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRAL 1308

Query: 1261 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTT 1320
            RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  C+N T 
Sbjct: 1309 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTE 1368

Query: 1321 GNM-FDISDVNNLSDCQALGKQAR--WKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAA 1377
            G++  + + VNN S C++L       W  VKVNFDNVGAGYLALLQVATFKGWMDIMYAA
Sbjct: 1369 GDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAA 1428

Query: 1378 VDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMT 1437
            VDSR  + QP +E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMT
Sbjct: 1429 VDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMT 1488

Query: 1438 EEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVE 1497
            EEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTMMVE
Sbjct: 1489 EEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVE 1548

Query: 1498 TDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFL 1557
            TDDQ      +L++INL+F+ +FTGE ++KL +LRHYYFT  WNIFDFVVVILSIVG  L
Sbjct: 1549 TDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVL 1608

Query: 1558 AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVM 1617
            +++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVM
Sbjct: 1609 SDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVM 1668

Query: 1618 FIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDC 1677
            FIY+IFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP C
Sbjct: 1669 FIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYC 1728

Query: 1678 DPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLS 1737
            DP T+   +  +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EPLS
Sbjct: 1729 DP-TLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLS 1787

Query: 1738 EDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDR 1797
            EDDF+MFYE+WEKFDP+ATQFIE+S LSDFA AL  PL IAKPN++ LI MDLPMVSGDR
Sbjct: 1788 EDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDR 1847

Query: 1798 IHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAI 1857
            IHC+DILFAFTKRVLGESGEMDAL+IQME++FMA+NPSK+SYEPITTTL+RK EEVSA +
Sbjct: 1848 IHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMV 1907

Query: 1858 IQRNFRCYLLKQRLKNISSNYNKEAIKG--RIDLPIKQDMIIDKLNGNST----PEKTDG 1911
            IQR FR +LL++ LK+ S  + ++A  G    D P ++ +I   ++ N +    P  +  
Sbjct: 1908 IQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSS 1967

Query: 1912 SSSTTSPPSYDSVTKPDKEKFE 1933
             SST+ PPSYDSVT+   +  +
Sbjct: 1968 ISSTSFPPSYDSVTRATSDNLQ 1989


>gi|150417967 voltage-gated sodium channel type V alpha isoform c
            [Homo sapiens]
          Length = 2016

 Score = 2377 bits (6160), Expect = 0.0
 Identities = 1268/2062 (61%), Positives = 1501/2062 (72%), Gaps = 211/2062 (10%)

Query: 6    LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDN----DDENKPKPNSDLEAGKNL 61
            L+P G  SFR FTRESLAAIEKR AE++A+     Q++     +E  P+P  DL+A K L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 62   PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIA 121
            P +YG+ P E++ EPLEDLDP+Y  +KTFIV+NKGK IFRFSAT+ALY+L+P +P+R+ A
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 122  IKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 181
            +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 182  DFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
             FTFLRDPWNWLDFSVI+MAYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244

Query: 242  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDS 301
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+        
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTAL------- 287

Query: 302  NGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRN 358
            NGT  +V      W+    Y+ D  ++ + +G  D LLCGN SDAG CPEGY C+KAG N
Sbjct: 288  NGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGEN 347

Query: 359  PNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNL 418
            P++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYLVNL
Sbjct: 348  PDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNL 407

Query: 419  ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGL 478
            ILAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                 I G+
Sbjct: 408  ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALT--------------IRGV 453

Query: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538
              +  SS E S L+  ++ E R++R+KR       G  +   D  PKS+SED  +  + L
Sbjct: 454  DTVSRSSLEMSPLAPVNSHERRSKRRKRMS----SGTEECGEDRLPKSDSEDGPRAMNHL 509

Query: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598
                G   TS K                    R+S+ SIF+FR R  D+GSE DFADDE+
Sbjct: 510  SLTRGLSRTSMKP-------------------RSSRGSIFTFRRR--DLGSEADFADDEN 548

Query: 599  STFEDSESRRDSLFVPHR---------------------HGERRNS---NG--------- 625
            ST  +SES   SL VP                       HG++ ++   NG         
Sbjct: 549  STAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGD 608

Query: 626  ---------------------TTTETEVR--KRRLSSYQISMEMLEDSSGRQRAVSIASI 662
                                 TTT +E     + L+S    ++  E+   RQRA+S  S+
Sbjct: 609  PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668

Query: 663  LTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIV 722
            LT+ +EELEESR KCPPCW R A  +LIW+CC  W+ +K  V L+VMDPF DL IT+CIV
Sbjct: 669  LTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIV 728

Query: 723  LNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGII 782
            LNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD II
Sbjct: 729  LNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSII 788

Query: 783  VSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 842
            V LSLMELGLS +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAI
Sbjct: 789  VILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAI 848

Query: 843  IVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDC 902
            IVFIFAVVGMQLFGK+Y E   + +D   LPRWHM DFFH+FLI+FR+LCGEWIETMWDC
Sbjct: 849  IVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDC 906

Query: 903  MEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRM 962
            MEV+GQ++CL+VF+LVMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ R+
Sbjct: 907  MEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARI 966

Query: 963  QKGIDYVKNKMRE-CFQKAFFRKPKVIEIHEGNKIDSCMSNNTGI------EISKELNYL 1015
            Q+G+ +VK    + C      R  K   +    ++ SC++           ++       
Sbjct: 967  QRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKET 1026

Query: 1016 RDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSES 1075
            R   G   G GT    E                   V VPIAV ESD ++   +E +S  
Sbjct: 1027 RFEEGEQPGQGTPGDPEP------------------VCVPIAVAESDTDDQEEDEENSLG 1068

Query: 1076 ELEESKEK---------------------LNATSSSE----------------------- 1091
              EES ++                     ++AT+SSE                       
Sbjct: 1069 TEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGC 1128

Query: 1092 ----------GSTVDVVLPREGEQAETEPEEDLK-PEACFTEGCIKKFPFCQVSTEEGKG 1140
                      GST D+    E  +   +  +D+K PE CFTEGC+++ P C V T +  G
Sbjct: 1129 GETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPG 1188

Query: 1141 KIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTY 1200
            K+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEYADK+FTY
Sbjct: 1189 KVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTY 1248

Query: 1201 IFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1260
            +F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSLVAN LG++E+G IKSLRTLRAL
Sbjct: 1249 VFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRAL 1308

Query: 1261 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTT 1320
            RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  C+N T 
Sbjct: 1309 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTE 1368

Query: 1321 GNM-FDISDVNNLSDCQALGKQAR--WKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAA 1377
            G++  + + VNN S C++L       W  VKVNFDNVGAGYLALLQVATFKGWMDIMYAA
Sbjct: 1369 GDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAA 1428

Query: 1378 VDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMT 1437
            VDSR  + QP +E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMT
Sbjct: 1429 VDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMT 1488

Query: 1438 EEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVE 1497
            EEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTMMVE
Sbjct: 1489 EEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVE 1548

Query: 1498 TDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFL 1557
            TDDQ      +L++INL+F+ +FTGE ++KL +LRHYYFT  WNIFDFVVVILSIVG  L
Sbjct: 1549 TDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVL 1608

Query: 1558 AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVM 1617
            +++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVM
Sbjct: 1609 SDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVM 1668

Query: 1618 FIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDC 1677
            FIY+IFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP C
Sbjct: 1669 FIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYC 1728

Query: 1678 DPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLS 1737
            DP T+   +  +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EPLS
Sbjct: 1729 DP-TLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLS 1787

Query: 1738 EDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDR 1797
            EDDF+MFYE+WEKFDP+ATQFIE+S LSDFA AL  PL IAKPN++ LI MDLPMVSGDR
Sbjct: 1788 EDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDR 1847

Query: 1798 IHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAI 1857
            IHC+DILFAFTKRVLGESGEMDAL+IQME++FMA+NPSK+SYEPITTTL+RK EEVSA +
Sbjct: 1848 IHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMV 1907

Query: 1858 IQRNFRCYLLKQRLKNISSNYNKEAIKG--RIDLPIKQDMIIDKLNGNST----PEKTDG 1911
            IQR FR +LL++ LK+ S  + ++A  G    D P ++ +I   ++ N +    P  +  
Sbjct: 1908 IQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSS 1967

Query: 1912 SSSTTSPPSYDSVTKPDKEKFE 1933
             SST+ PPSYDSVT+   +  +
Sbjct: 1968 ISSTSFPPSYDSVTRATSDNLQ 1989


>gi|150417969 voltage-gated sodium channel type V alpha isoform d
            [Homo sapiens]
          Length = 1998

 Score = 2331 bits (6041), Expect = 0.0
 Identities = 1251/2062 (60%), Positives = 1484/2062 (71%), Gaps = 229/2062 (11%)

Query: 6    LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDN----DDENKPKPNSDLEAGKNL 61
            L+P G  SFR FTRESLAAIEKR AE++A+     Q++     +E  P+P  DL+A K L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 62   PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIA 121
            P +YG+ P E++ EPLEDLDP+Y  +KTFIV+NKGK IFRFSAT+ALY+L+P +P+R+ A
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 122  IKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 181
            +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 182  DFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
             FTFLRDPWNWLDFSVI+MAYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244

Query: 242  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDS 301
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+        
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTAL------- 287

Query: 302  NGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRN 358
            NGT  +V      W+    Y+ D  ++ + +G  D LLCGN SDAG CPEGY C+KAG N
Sbjct: 288  NGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGEN 347

Query: 359  PNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNL 418
            P++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYLVNL
Sbjct: 348  PDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNL 407

Query: 419  ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGL 478
            ILAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                 I G+
Sbjct: 408  ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALT--------------IRGV 453

Query: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538
              +  SS E S L+  ++ E R++R+KR       G  +   D  PKS+SED  +  + L
Sbjct: 454  DTVSRSSLEMSPLAPVNSHERRSKRRKRMS----SGTEECGEDRLPKSDSEDGPRAMNHL 509

Query: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598
                G   TS K                    R+S+ SIF+FR R  D+GSE DFADDE+
Sbjct: 510  SLTRGLSRTSMKP-------------------RSSRGSIFTFRRR--DLGSEADFADDEN 548

Query: 599  STFEDSESRRDSLFVPHR---------------------HGERRNS---NG--------- 625
            ST  +SES   SL VP                       HG++ ++   NG         
Sbjct: 549  STAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGD 608

Query: 626  ---------------------TTTETEVR--KRRLSSYQISMEMLEDSSGRQRAVSIASI 662
                                 TTT +E     + L+S    ++  E+   RQRA+S  S+
Sbjct: 609  PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668

Query: 663  LTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIV 722
            LT+ +EELEESR KCPPCW R A  +LIW+CC  W+ +K  V L+VMDPF DL IT+CIV
Sbjct: 669  LTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIV 728

Query: 723  LNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGII 782
            LNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD II
Sbjct: 729  LNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSII 788

Query: 783  VSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 842
            V LSLMELGLS +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAI
Sbjct: 789  VILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAI 848

Query: 843  IVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDC 902
            IVFIFAVVGMQLFGK+Y E   + +D   LPRWHM DFFH+FLI+FR+LCGEWIETMWDC
Sbjct: 849  IVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDC 906

Query: 903  MEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRM 962
            MEV+GQ++CL+VF+LVMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ R+
Sbjct: 907  MEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARI 966

Query: 963  QKGIDYVKNKMRE-CFQKAFFRKPKVIEIHEGNKIDSCMSNNTGI------EISKELNYL 1015
            Q+G+ +VK    + C      R  K   +    ++ SC++           ++       
Sbjct: 967  QRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKET 1026

Query: 1016 RDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSES 1075
            R   G   G GT    E                   V VPIAV ESD ++   +E +S  
Sbjct: 1027 RFEEGEQPGQGTPGDPEP------------------VCVPIAVAESDTDDQEEDEENSLG 1068

Query: 1076 ELEESKEK---------------------LNATSSSE----------------------- 1091
              EES ++                     ++AT+SSE                       
Sbjct: 1069 TEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGC 1128

Query: 1092 ----------GSTVDVVLPREGEQAETEPEEDLK-PEACFTEGCIKKFPFCQVSTEEGKG 1140
                      GST D+    E  +   +  +D+K PE CFTEGC+++ P C V T +  G
Sbjct: 1129 GETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPG 1188

Query: 1141 KIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTY 1200
            K+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEYADK+FTY
Sbjct: 1189 KVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTY 1248

Query: 1201 IFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1260
            +F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSLVAN LG++E+G IKSLRTLRAL
Sbjct: 1249 VFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRAL 1308

Query: 1261 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTT 1320
            RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  C+N T 
Sbjct: 1309 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTE 1368

Query: 1321 GNM-FDISDVNNLSDCQALGKQAR--WKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAA 1377
            G++  + + VNN S C++L       W  VKVNFDNVGAGYLALLQV             
Sbjct: 1369 GDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQV------------- 1415

Query: 1378 VDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMT 1437
                  + QP +E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMT
Sbjct: 1416 -----YEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMT 1470

Query: 1438 EEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVE 1497
            EEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTMMVE
Sbjct: 1471 EEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVE 1530

Query: 1498 TDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFL 1557
            TDDQ      +L++INL+F+ +FTGE ++KL +LRHYYFT  WNIFDFVVVILSIVG  L
Sbjct: 1531 TDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVL 1590

Query: 1558 AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVM 1617
            +++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVM
Sbjct: 1591 SDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVM 1650

Query: 1618 FIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDC 1677
            FIY+IFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP C
Sbjct: 1651 FIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYC 1710

Query: 1678 DPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLS 1737
            DP T+   +  +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EPLS
Sbjct: 1711 DP-TLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLS 1769

Query: 1738 EDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDR 1797
            EDDF+MFYE+WEKFDP+ATQFIE+S LSDFA AL  PL IAKPN++ LI MDLPMVSGDR
Sbjct: 1770 EDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDR 1829

Query: 1798 IHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAI 1857
            IHC+DILFAFTKRVLGESGEMDAL+IQME++FMA+NPSK+SYEPITTTL+RK EEVSA +
Sbjct: 1830 IHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMV 1889

Query: 1858 IQRNFRCYLLKQRLKNISSNYNKEAIKG--RIDLPIKQDMIIDKLNGNST----PEKTDG 1911
            IQR FR +LL++ LK+ S  + ++A  G    D P ++ +I   ++ N +    P  +  
Sbjct: 1890 IQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSS 1949

Query: 1912 SSSTTSPPSYDSVTKPDKEKFE 1933
             SST+ PPSYDSVT+   +  +
Sbjct: 1950 ISSTSFPPSYDSVTRATSDNLQ 1971


>gi|237512980 voltage-gated sodium channel type V alpha isoform e
            [Homo sapiens]
          Length = 1983

 Score = 2311 bits (5988), Expect = 0.0
 Identities = 1245/2061 (60%), Positives = 1476/2061 (71%), Gaps = 242/2061 (11%)

Query: 6    LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDN----DDENKPKPNSDLEAGKNL 61
            L+P G  SFR FTRESLAAIEKR AE++A+     Q++     +E  P+P  DL+A K L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 62   PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIA 121
            P +YG+ P E++ EPLEDLDP+Y  +KTFIV+NKGK IFRFSAT+ALY+L+P +P+R+ A
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 122  IKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 181
            +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 182  DFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
             FTFLRDPWNWLDFSVI+MAYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244

Query: 242  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDS 301
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+        
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTAL------- 287

Query: 302  NGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRN 358
            NGT  +V      W+    Y+ D  ++ + +G  D LLCGN SDAG CPEGY C+KAG N
Sbjct: 288  NGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGEN 347

Query: 359  PNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNL 418
            P++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYLVNL
Sbjct: 348  PDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNL 407

Query: 419  ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGL 478
            ILAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                 I G+
Sbjct: 408  ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALT--------------IRGV 453

Query: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538
              +  SS E S L+  ++ E R++R+KR       G  +   D  PKS+SED  +  + L
Sbjct: 454  DTVSRSSLEMSPLAPVNSHERRSKRRKRMS----SGTEECGEDRLPKSDSEDGPRAMNHL 509

Query: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598
                G   TS K                    R+S+ SIF+FR R  D+GSE DFADDE+
Sbjct: 510  SLTRGLSRTSMKP-------------------RSSRGSIFTFRRR--DLGSEADFADDEN 548

Query: 599  STFEDSESRRDSLFVPHR---------------------HGERRNS---NG--------- 625
            ST  +SES   SL VP                       HG++ ++   NG         
Sbjct: 549  STAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGD 608

Query: 626  ---------------------TTTETEVR--KRRLSSYQISMEMLEDSSGRQRAVSIASI 662
                                 TTT +E     + L+S    ++  E+   RQRA+S  S+
Sbjct: 609  PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668

Query: 663  LTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIV 722
            LT+ +EELEESR KCPPCW R A  +LIW+CC  W+ +K  V L+VMDPF DL IT+CIV
Sbjct: 669  LTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIV 728

Query: 723  LNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGII 782
            LNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD II
Sbjct: 729  LNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSII 788

Query: 783  VSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 842
            V LSLMELGLS +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLAI
Sbjct: 789  VILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAI 848

Query: 843  IVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDC 902
            IVFIFAVVGMQLFGK+Y E   + +D   LPRWHM DFFH+FLI+FR+LCGEWIETMWDC
Sbjct: 849  IVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDC 906

Query: 903  MEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRM 962
            MEV+GQ++CL+VF+LVMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ R+
Sbjct: 907  MEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARI 966

Query: 963  QKGIDYVKNKMRE-CFQKAFFRKPKVIEIHEGNKIDSCMSNNTGI------EISKELNYL 1015
            Q+G+ +VK    + C      R  K   +    ++ SC++           ++       
Sbjct: 967  QRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKET 1026

Query: 1016 RDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFEN--------LN 1067
            R   G   G GT    E                   V VPIAV ESD ++        L 
Sbjct: 1027 RFEEGEQPGQGTPGDPEP------------------VCVPIAVAESDTDDQEEDEENSLG 1068

Query: 1068 TEEFSSESELE------------ESKEKLNATSSSE------------------------ 1091
            TEE SS+ E +             +  +++AT+SSE                        
Sbjct: 1069 TEEESSKQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCG 1128

Query: 1092 ---------GSTVDVVLPREGEQAETEPEEDLK-PEACFTEGCIKKFPFCQVSTEEGKGK 1141
                     GST D+    E  +   +  +D+K PE CFTEGC+++ P C V T +  GK
Sbjct: 1129 ETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGK 1188

Query: 1142 IWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYI 1201
            +WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEYADK+FTY+
Sbjct: 1189 VWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYV 1248

Query: 1202 FILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALR 1261
            F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSLVAN LG++E+G IKSLRTLRALR
Sbjct: 1249 FVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1308

Query: 1262 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTG 1321
            PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  C+N T G
Sbjct: 1309 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEG 1368

Query: 1322 NM-FDISDVNNLSDCQALG--KQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAV 1378
            ++  + + VNN S C++L    +  W  VKVNFDNVGAGYLALLQVATFKGWMDIMYAAV
Sbjct: 1369 DLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAV 1428

Query: 1379 DSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTE 1438
            DSR  + QP +E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTE
Sbjct: 1429 DSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTE 1488

Query: 1439 EQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVET 1498
            EQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTMMVET
Sbjct: 1489 EQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVET 1548

Query: 1499 DDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLA 1558
            DDQ      +L++INL+F+ +FT                                G  L+
Sbjct: 1549 DDQSPEKINILAKINLLFVAIFT--------------------------------GTVLS 1576

Query: 1559 EMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1618
            ++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVMF
Sbjct: 1577 DIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1636

Query: 1619 IYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCD 1678
            IY+IFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP CD
Sbjct: 1637 IYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCD 1696

Query: 1679 PDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1738
            P T+   +  +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EPLSE
Sbjct: 1697 P-TLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSE 1755

Query: 1739 DDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRI 1798
            DDF+MFYE+WEKFDP+ATQFIE+S LSDFA AL  PL IAKPN++ LI MDLPMVSGDRI
Sbjct: 1756 DDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRI 1815

Query: 1799 HCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAII 1858
            HC+DILFAFTKRVLGESGEMDAL+IQME++FMA+NPSK+SYEPITTTL+RK EEVSA +I
Sbjct: 1816 HCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVI 1875

Query: 1859 QRNFRCYLLKQRLKNISSNYNKEAIKG--RIDLPIKQDMIIDKLNGNST----PEKTDGS 1912
            QR FR +LL++ LK+ S  + ++A  G    D P ++ +I   ++ N +    P  +   
Sbjct: 1876 QRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSI 1935

Query: 1913 SSTTSPPSYDSVTKPDKEKFE 1933
            SST+ PPSYDSVT+   +  +
Sbjct: 1936 SSTSFPPSYDSVTRATSDNLQ 1956


>gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo
            sapiens]
          Length = 1956

 Score = 2110 bits (5467), Expect = 0.0
 Identities = 1128/2008 (56%), Positives = 1397/2008 (69%), Gaps = 187/2008 (9%)

Query: 13   SFRLFTRESLAAIEKRAAEEKAKKPKKE---QDNDDENKPKPNSDLEAGKNLPFIYGDIP 69
            +FR FT ESL  IEK+ A ++  K  +E   +  D E KP+P  DL+A   LP  YG++P
Sbjct: 12   NFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEKPRPQLDLKACNQLPKFYGELP 71

Query: 70   PEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHSL 129
             E++ EPLEDLDP+Y   +TF+V+NKG+ I RFSAT AL++ +P N +R+ AIK+ VHS 
Sbjct: 72   AELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSVHSW 131

Query: 130  FSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDP 189
            FS+ I  TIL NCV MT ++ P+    +EY FT IYTFE+LIKILARGFCL +FT+LRDP
Sbjct: 132  FSLFITVTILVNCVCMTRTDLPE---KIEYVFTVIYTFEALIKILARGFCLNEFTYLRDP 188

Query: 190  WNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSD 249
            WNWLDFSVI +AYV   +DL  +S LRTFRVLRALKT+SVIPGLK IVGALI SVKKL+D
Sbjct: 189  WNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLAD 248

Query: 250  VMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVT 309
            V ILT+FCLSVFAL+GLQLF GNL+NKC++                      N   VN  
Sbjct: 249  VTILTIFCLSVFALVGLQLFKGNLKNKCVK----------------------NDMAVN-- 284

Query: 310  MSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTF 369
              T N+  +   D +     G  DPLLCGNGSD+G CP+GYIC+K   NP++ YTSFD+F
Sbjct: 285  -ETTNYSSHRKPDIYINKR-GTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSF 342

Query: 370  SWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEE 429
            +WAFLSLFRLMTQD WE LYQ TLR +GK YMIFFVLVIFLGSFYLVNLILAVV MAYEE
Sbjct: 343  AWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEE 402

Query: 430  QNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGELLESSSEAS 489
            QNQAT +E E KE +FQ+ LE L+K+QE   A+   + +    +G              S
Sbjct: 403  QNQATTDEIEAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNG--------------S 448

Query: 490  KLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFSMDGNRLTSD 549
             L+SK+A E R+R K R      E N     D +       + +R SFL           
Sbjct: 449  PLTSKNASERRHRIKPRVSEGSTEDNKSPRSDPY-------NQRRMSFL----------- 490

Query: 550  KKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHSTFE-DSESRR 608
                          G     RR S  S+F FR   +D+       DD    F  D ES R
Sbjct: 491  --------------GLASGKRRASHGSVFHFRSPGRDISLPEGVTDD--GVFPGDHESHR 534

Query: 609  DSLFV---------------------PHRHGERRNSNGTTTETEVRKRRLSSYQ------ 641
             SL +                       RHGE  +    T+E       +S++       
Sbjct: 535  GSLLLGGGAGQQGPLPRSPLPQPSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKT 594

Query: 642  -ISMEMLEDSSGRQRAVSIASILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKV 700
             +S E L++    QRA+S+ SI+T+ +EELEES QKCPPC    +  +LIWDCC  W+K+
Sbjct: 595  FLSAEYLDEPFRAQRAMSVVSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKL 654

Query: 701  KHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVL 760
            K ++  +V DPF +L IT+CIV+NT+FMAMEH+ M+  F ++L +GN+VFT  FTAEMV 
Sbjct: 655  KTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVF 714

Query: 761  KIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLN 820
            KIIA DPYYYFQ+ WNIFD IIV++SL+ELG++    LSVLRSFRLLRVFKLAKSWPTLN
Sbjct: 715  KIIAFDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLN 774

Query: 821  MLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY---KECVCKINDDCTLPRWHM 877
             LIKIIGNSVGALGNLT++LAIIVF+FA+VG QL G++Y   ++ +   ++D   PRWHM
Sbjct: 775  TLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHED--WPRWHM 832

Query: 878  NDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSS 937
            +DFFHSFLIVFR+LCGEWIE MW CMEV  +++CLI+F+ VMV+GNLVVLNLF+ALLL+S
Sbjct: 833  HDFFHSFLIVFRILCGEWIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNS 892

Query: 938  FSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQKAF-FRKPKVIEIHEGNKI 996
            FS+DNL A +DD E+NNLQ+A+ R+Q      K  +   F ++  F +PK          
Sbjct: 893  FSADNLTAPEDDGEVNNLQVALARIQVFGHRTKQALCSFFSRSCPFPQPKA--------- 943

Query: 997  DSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPI 1056
            +  +     +  SK  N++     T  G   G    +   DE  +  FI NP++ V+VPI
Sbjct: 944  EPELVVKLPLSSSKAENHI--AANTARGSSGGLQAPRGPRDE--HSDFIANPTVWVSVPI 999

Query: 1057 AVGESDFENLNT------------------------------------------------ 1068
            A GESD ++L                                                  
Sbjct: 1000 AEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLAP 1059

Query: 1069 ---EEFSSESELEESKEKLNATSSSEGSTVDVVLPREGEQAETEPEEDL-KPEACFTEGC 1124
               E +  ES  +   E ++ TSSSEGSTVD + P E  +   E  +DL +P+ CFTEGC
Sbjct: 1060 SLGETWKDESVPQVPAEGVDDTSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGC 1119

Query: 1125 IKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQR 1184
            I+  P C++ T +    + W +RKTCY IVEH+WFE+FI+FMILLSSG+LAFED Y++Q+
Sbjct: 1120 IRHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQK 1179

Query: 1185 KTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALG 1244
             T+K +LEY D+VFT+IF+ EMLLKWVAYGF+ YFTNAWCWLDFLIV++SL+SL A  L 
Sbjct: 1180 PTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILE 1239

Query: 1245 YSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMG 1304
            YSE+  IK+LRTLRALRPLRALSRFEGMRVVV+ALVGAIPSIMNVLLVCLIFWLIFSIMG
Sbjct: 1240 YSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMG 1299

Query: 1305 VNLFAGKFYHCVNMTTG--NMFDISDVNNLSDCQALGKQAR--WKNVKVNFDNVGAGYLA 1360
            VNLFAGKF+ C+N T G  ++  +S VNN SDC+         W NVKVNFDNV  GYLA
Sbjct: 1300 VNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLA 1359

Query: 1361 LLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIID 1420
            LLQVATFKGWMDIMYAAVDSR+V +QP +E+N+YMYLYFVIFIIFG FFTLNLF+GVIID
Sbjct: 1360 LLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIID 1419

Query: 1421 NFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFD 1480
            NFNQQKKK GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NKFQG VFD VTRQ FD
Sbjct: 1420 NFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFD 1479

Query: 1481 ISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGW 1540
            I+IM+LICLNM+TMMVETDDQ +  T +L +IN  F+ +FTGE V+K+ +LR YYFT GW
Sbjct: 1480 ITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGW 1539

Query: 1541 NIFDFVVVILSIVGMFLAEMIE--KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFA 1598
            N+FDF+VV+LSI  +  + +++  + + SPTLFRVIRLARIGRILRLI+ AKGIRTLLFA
Sbjct: 1540 NVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFA 1599

Query: 1599 LMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITT 1658
            LMMSLPALFNIGLLLFLVMFIY+IFGMS+F +V+ EAGIDDMFNF+TF NSM+CLFQITT
Sbjct: 1600 LMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITT 1659

Query: 1659 SAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYI 1718
            SAGWDGLL+PILN+ PP CDP+ +   +  +GDCG+P+VGI FF +YIIISFL++VNMYI
Sbjct: 1660 SAGWDGLLSPILNTGPPYCDPN-LPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYI 1718

Query: 1719 AVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIA 1778
            AVILENF+VATEES EPLSEDDF+MFYE WEKFDP+ATQFI FS LSDFA  L  PL I 
Sbjct: 1719 AVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIP 1778

Query: 1779 KPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVS 1838
            KPN+  LI MDLP+V GD+IHCLDILFAFTK VLGESGE+D+L+  ME++FMA+N SK S
Sbjct: 1779 KPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDSLKANMEEKFMATNLSKSS 1838

Query: 1839 YEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIID 1898
            YEPI TTL+ KQE++SA +IQ+ +R Y+L + +   ++     A +    LP +  +   
Sbjct: 1839 YEPIATTLRWKQEDISATVIQKAYRSYVLHRSMALSNTPCVPRAEEEAASLPDEGFVAFT 1898

Query: 1899 KLNGNSTPEKTDGSSSTTSPPSYDSVTK 1926
                   P+K++ +S+T+ PPSY+SVT+
Sbjct: 1899 ANENCVLPDKSETASATSFPPSYESVTR 1926


>gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapiens]
          Length = 1836

 Score = 1817 bits (4707), Expect = 0.0
 Identities = 925/1290 (71%), Positives = 1063/1290 (82%), Gaps = 20/1290 (1%)

Query: 643  SMEMLEDSSGRQRAVSIA-SILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVK 701
            S++  +   G  R  S   S +++ MEELEE+ QKCPP WY+ A+  LIW+CC  WLK K
Sbjct: 509  SLDTSQGEKGAPRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFK 568

Query: 702  HLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLK 761
            ++++LIVMDPFVDL ITICIVLNTLFMAMEHYPMTE F +VLTVGNLVFTGIFTAEMVLK
Sbjct: 569  NIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLK 628

Query: 762  IIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNM 821
            +IAMDPY YFQ+GWNIFD IIV+LSL+ELGL+NV+GLSVLRSFRLLRVFKLAKSWPTLNM
Sbjct: 629  LIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNM 688

Query: 822  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFF 881
            LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI  DC LPRWHM+DFF
Sbjct: 689  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFF 748

Query: 882  HSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSD 941
            HSFLIVFR+LCGEWIETMWDCMEVAGQ MCL VF++VMVIGNLVVLNLFLALLLSSFS+D
Sbjct: 749  HSFLIVFRILCGEWIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSAD 808

Query: 942  NLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKIDSCMS 1001
            +LAA+D+D EMNNLQIA+GR++ GI + K  +           PK I +  G    +  +
Sbjct: 809  SLAASDEDGEMNNLQIAIGRIKLGIGFAKAFLLGLLHGKIL-SPKDIMLSLGEADGAGEA 867

Query: 1002 NNTGIEISKELNY------LRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVP 1055
               G    ++         L+  N   + +G        +  E D+++FINNP LT+ VP
Sbjct: 868  GEAGETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSL--ELDHLNFINNPYLTIQVP 925

Query: 1056 IAVGESDFENLNTEEFSSESELEESK---EKLNATSSSEGSTVDVVLPREG--EQAETEP 1110
            IA  ESD E    EE  + SE E+SK   + L   +SS  ST D   P E   EQAE  P
Sbjct: 926  IASEESDLEMPTEEETDTFSEPEDSKKPPQPLYDGNSSVCSTADYKPPEEDPEEQAEENP 985

Query: 1111 EEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLS 1170
            E + +PE CFTE C++++P   V   +G+GK WW LR+ C+ IVEHNWFETFIVFMILLS
Sbjct: 986  EGE-QPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLS 1044

Query: 1171 SGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLI 1230
            SGALAFEDIYIEQR+ I+T+LEYADKVFTYIFI+EMLLKWVAYGF+ YFTNAWCWLDFLI
Sbjct: 1045 SGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLI 1104

Query: 1231 VDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1290
            VDVS++SLVAN LGYSELG IKSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVL
Sbjct: 1105 VDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVL 1164

Query: 1291 LVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNNLSDCQAL--GKQARWKNVK 1348
            LVCLIFWLIFSIMGVNLFAGKFY+C+N TT   FDIS+VNN S+C++L    Q RW NVK
Sbjct: 1165 LVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEVNNKSECESLMHTGQVRWLNVK 1224

Query: 1349 VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSF 1408
            VN+DNVG GYL+LLQVATFKGWMDIMYAAVDSR+ + QP YE NLYMYLYFVIFIIFGSF
Sbjct: 1225 VNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSF 1284

Query: 1409 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQG 1468
            FTLNLFIGVIIDNFNQQKKK GG+DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG
Sbjct: 1285 FTLNLFIGVIIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQG 1344

Query: 1469 MVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKL 1528
            MV+D VT+Q FDI+IMILICLNMVTMMVETD+Q +    +L  IN++FI++FTGE VLK+
Sbjct: 1345 MVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKM 1404

Query: 1529 VSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKG 1588
            ++LR YYFT+GWNIFDFVVVILSIVG+ L+++I+KYFVSPTLFRVIRLARIGR+LRLI+G
Sbjct: 1405 LALRQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRG 1464

Query: 1589 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGN 1648
            AKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGMSNFAYVKKE+GIDDMFNFETFGN
Sbjct: 1465 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGN 1524

Query: 1649 SMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIII 1708
            S+ICLF+ITTSAGWDGLL PILNS PPDCDP+  +PG+SVKGDCGNPS+GI FF SYIII
Sbjct: 1525 SIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIII 1584

Query: 1709 SFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFA 1768
            SFL+VVNMYIA+ILENF+VATEES+EPL EDDFEMFYE WEKFDPDATQFI +S+LSDF 
Sbjct: 1585 SFLIVVNMYIAIILENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFV 1644

Query: 1769 AALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDR 1828
              L  PL IAKPNK++LI +DLPMV GD+IHCLDILFA TK VLG+SGEMDAL+  ME++
Sbjct: 1645 DTLQEPLRIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEK 1704

Query: 1829 FMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRLKNISSNYNKEAIKGRID 1888
            FMA+NPSKVSYEPITTTLKRK EEV A  IQR +R +LL++ +K  S  Y         D
Sbjct: 1705 FMAANPSKVSYEPITTTLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSGDD 1764

Query: 1889 LPIKQDMIIDKLNGNSTPEKTDGSSSTTSP 1918
             P K+ ++ + ++     E  +G+SS+ SP
Sbjct: 1765 APEKEGLLANTMSKMYGHE--NGNSSSPSP 1792



 Score =  698 bits (1802), Expect = 0.0
 Identities = 348/484 (71%), Positives = 396/484 (81%), Gaps = 24/484 (4%)

Query: 6   LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFIY 65
           LVP GPE  R FTRESLAAIE+RA EE+A+  + +Q   +E + KP SDLEAGKNLP IY
Sbjct: 9   LVPLGPECLRPFTRESLAAIEQRAVEEEARLQRNKQMEIEEPERKPRSDLEAGKNLPMIY 68

Query: 66  GDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKIL 125
           GD PPE++  PLEDLDPYY NKKTFIV+NKGKAIFRFSAT ALY+L+P + VR+ AIK+L
Sbjct: 69  GDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIKVL 128

Query: 126 VHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTF 185
           +H+LFSM IM TILTNCVFMT+S+PP W+KNVEYTFTGIYTFESLIKILARGFC++DFTF
Sbjct: 129 IHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDDFTF 188

Query: 186 LRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVK 245
           LRDPWNWLDFSVI+MAY+TEFVDLGN+SALRTFRVLRALKTI+VIPGLKTIVGALIQSVK
Sbjct: 189 LRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVK 248

Query: 246 KLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTF 305
           KLSDVMILTVFCLSVFAL+GLQLFMGNLR KC++WPP  +  +TNTT Y N T   N T+
Sbjct: 249 KLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFN--DTNTTWYSNDTWYGNDTW 306

Query: 306 VN----------------------VTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDA 343
                                    T  TF+W  YI D+ +FY L+G  D LLCGN SDA
Sbjct: 307 YGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDA 366

Query: 344 GQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIF 403
           G CPEGY C+K GRNPNYGYTS+DTFSWAFL+LFRLMTQDYWENL+QLTLRAAGKTYMIF
Sbjct: 367 GHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIF 426

Query: 404 FVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVA 463
           FV++IFLGSFYL+NLILAVVAMAY EQN+ATL E ++KE EFQQMLE+ KK QEE +   
Sbjct: 427 FVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEKAK 486

Query: 464 AASA 467
           AA A
Sbjct: 487 AAQA 490



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 76/340 (22%), Positives = 144/340 (42%), Gaps = 80/340 (23%)

Query: 117  VRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNV-----EYT---FTGIYTFE 168
            +R+   KI+ H+ F   I+  IL +   +   +     + V     EY    FT I+  E
Sbjct: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079

Query: 169  SLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVT------EFVDLGNVSALRTFRVLR 222
             L+K +A GF +    +  + W WLDF ++ ++ ++       + +LG + +LRT R LR
Sbjct: 1080 MLLKWVAYGFKV----YFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135

Query: 223  ALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP 282
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G           
Sbjct: 1136 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY-------- 1187

Query: 283  SDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSD 342
                  T T+  F+ +  +N +     M T                              
Sbjct: 1188 --YCINTTTSERFDISEVNNKSECESLMHT------------------------------ 1215

Query: 343  AGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGK---- 398
             GQ    ++ VK     NY     D     +LSL ++ T   W ++    + +  K    
Sbjct: 1216 -GQV--RWLNVKV----NY-----DNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQP 1263

Query: 399  -----TYM-IFFVLVIFLGSFYLVNLILAVVAMAYEEQNQ 432
                  YM ++FV+ I  GSF+ +NL + V+   + +Q +
Sbjct: 1264 QYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1303



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 46/169 (27%), Positives = 87/169 (51%), Gaps = 18/169 (10%)

Query: 1146 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1205
            +R+    ++ H  F  FI+  IL +   +   D     +      +EY    FT I+  E
Sbjct: 120  VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKN-----VEYT---FTGIYTFE 171

Query: 1206 MLLKWVAYGFQ----TYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALR 1261
             L+K +A GF     T+  + W WLDF ++      ++A    + +LG I +LRT R LR
Sbjct: 172  SLIKILARGFCVDDFTFLRDPWNWLDFSVI------MMAYLTEFVDLGNISALRTFRVLR 225

Query: 1262 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1310
             L+ ++   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G
Sbjct: 226  ALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 50/184 (27%), Positives = 92/184 (50%), Gaps = 17/184 (9%)

Query: 707 IVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIA-- 764
           +++     + I I I+ N +FM M   P   +           FTGI+T E ++KI+A  
Sbjct: 127 VLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEY------TFTGIYTFESLIKILARG 180

Query: 765 --MDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNML 822
             +D + + ++ WN  D  ++ ++ +     ++  +S LR+FR+LR  K     P L  +
Sbjct: 181 FCVDDFTFLRDPWNWLDFSVIMMAYLT-EFVDLGNISALRTFRVLRALKTITVIPGLKTI 239

Query: 823 IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV---CKINDDCTLPRWHMN 878
           +  +  SV  L ++ ++    + +FA+VG+QLF G   ++CV      ND  T   W+ N
Sbjct: 240 VGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFND--TNTTWYSN 297

Query: 879 DFFH 882
           D ++
Sbjct: 298 DTWY 301



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 45/164 (27%), Positives = 84/164 (51%), Gaps = 16/164 (9%)

Query: 124 ILVHSLFSMLIMCTILTNCVFMTLSNPP--DWTKNV----EYTFTGIYTFESLIKILARG 177
           I++     + I   I+ N +FM + + P  +   NV       FTGI+T E ++K++A  
Sbjct: 574 IVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIA-- 631

Query: 178 FCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNV---SALRTFRVLRALKTISVIPGLK 234
             ++ + + +  WN  D  ++ ++ V   + L NV   S LR+FR+LR  K     P L 
Sbjct: 632 --MDPYEYFQQGWNIFDSIIVTLSLVE--LGLANVQGLSVLRSFRLLRVFKLAKSWPTLN 687

Query: 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCL 278
            ++  +  SV  L ++ ++    + +FA++G+QLF G    +C+
Sbjct: 688 MLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730



 Score = 40.4 bits (93), Expect = 0.017
 Identities = 28/119 (23%), Positives = 58/119 (48%), Gaps = 14/119 (11%)

Query: 880 FFHSFLIVFRVLCGEWIETMWDC-MEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSF 938
           F  +FL +FR++  ++ E ++   +  AG+T  +I F++++ +G+  ++NL LA++  ++
Sbjct: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTY-MIFFVVIIFLGSFYLINLILAVVAMAY 450

Query: 939 SSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKID 997
           +  N A   +D E           Q+ ++  K    E        K K  +  EG + D
Sbjct: 451 AEQNEATLAEDKEKEE------EFQQMLEKFKKHQEE------LEKAKAAQALEGGEAD 497



 Score = 36.2 bits (82), Expect = 0.32
 Identities = 28/129 (21%), Positives = 53/129 (41%), Gaps = 12/129 (9%)

Query: 1321 GNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDS 1380
            GN  D        +C   G+   +     ++D     +LAL ++ T   W ++    + +
Sbjct: 361  GNSSDAGHCPEGYECIKTGRNPNYGYT--SYDTFSWAFLALFRLMTQDYWENLFQLTLRA 418

Query: 1381 RDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1440
                         YM ++FV+ I  GSF+ +NL + V+   + +Q +    +D    EE 
Sbjct: 419  AG---------KTYM-IFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEF 468

Query: 1441 KKYYNAMKK 1449
            ++     KK
Sbjct: 469  QQMLEKFKK 477



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 16/69 (23%), Positives = 38/69 (55%)

Query: 369 FSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYE 428
           F  +FL +FR++  ++ E ++     A     +  F++V+ +G+  ++NL LA++  ++ 
Sbjct: 747 FFHSFLIVFRILCGEWIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFS 806

Query: 429 EQNQATLEE 437
             + A  +E
Sbjct: 807 ADSLAASDE 815


>gi|111378393 sodium channel, voltage-gated, type VII, alpha [Homo
            sapiens]
          Length = 1682

 Score = 1306 bits (3380), Expect = 0.0
 Identities = 671/1253 (53%), Positives = 890/1253 (71%), Gaps = 40/1253 (3%)

Query: 627  TTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELEESRQKCPPCWYRFAN 686
            T + E++KR   S   S+++LED++ R +            EELE+S++ CP  WY+FA 
Sbjct: 433  TIQIEMKKRSPISTDTSLDVLEDATLRHK------------EELEKSKKICPLYWYKFAK 480

Query: 687  VFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVG 746
             FLIW+C   WLK+K  V+ I+M PF DL + ICI+LN  F+ +EHYPM++Q +++L +G
Sbjct: 481  TFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIG 540

Query: 747  NLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRL 806
            NLVF GIFTAEM+ KIIAM PY YFQ GWNIFD +IV   L+EL L+NV G+++LR FR+
Sbjct: 541  NLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALLRLFRM 600

Query: 807  LRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI 866
            LR+FKL K WPT  +L+  + NS  AL +L L+L   +F  A  GM+LFGK+Y+E VC I
Sbjct: 601  LRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHI 660

Query: 867  NDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMLVMVIGNLVV 926
            + DC LPRWHM+DFFHSFL VFR+LCGEW+ET+WDCMEVAGQ+ C+  +++V++IGNL+V
Sbjct: 661  DKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMVILIGNLLV 720

Query: 927  LNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQKAFFRKPK 986
            L LFLAL+ SSFSS      +++NE  NLQ+AV R++KGI+YV  K+    Q      PK
Sbjct: 721  LYLFLALV-SSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQNV----PK 775

Query: 987  VIEIHEGNK-IDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFI 1045
                H     +   +S++T  E+S   ++L+D   +       S  EK    EN+  S I
Sbjct: 776  DTMDHVNEVYVKEDISDHTLSELSNTQDFLKDKEKS-------SGTEKNAT-ENESQSLI 827

Query: 1046 NNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSEGSTVDVVLPREGEQ 1105
             +PS++ TVPIA GESD ENL+ +E  S+S    SKEK+  +SSSE STVD+ +  E E 
Sbjct: 828  PSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEM 887

Query: 1106 AET-EPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIV 1164
                E  + LK       GC +     Q+S    KGKIW N+RKTC  IVE+NWF+ FI 
Sbjct: 888  FYGGERSKHLK------NGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFKCFIG 941

Query: 1165 FMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWC 1224
             + LLS+G LAFEDIY++QRKTIK +LEYAD +FTYIFILEMLLKW+AYGF+ YF+N W 
Sbjct: 942  LVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWY 1001

Query: 1225 WLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIP 1284
             LDF++V V  +SL+           +K L +++ LRPLR LS+FE M+VVV AL+    
Sbjct: 1002 RLDFVVVIVFCLSLIGKTRE-----ELKPLISMKFLRPLRVLSQFERMKVVVRALIKTTL 1056

Query: 1285 SIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNNLSDCQAL--GKQA 1342
              +NV LVCL+ WLIFSIMGV+LFAG+FY C++ T+G  F  S+V N S C++L   +  
Sbjct: 1057 PTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNKSRCESLLFNESM 1116

Query: 1343 RWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIF 1402
             W+N K+NFDNVG G+L+LLQVATF GW+ IM +A+DS  V +QP +E N+YMY YF+ F
Sbjct: 1117 LWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINF 1176

Query: 1403 IIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP 1462
            IIFG F  L++ I VIIDNFN+ K K GG +IF+T +Q+K Y  +KKL  +  Q+P+PRP
Sbjct: 1177 IIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRP 1236

Query: 1463 ANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTG 1522
             NK QG +FD VT Q F++ +M+LIC   + MM++TD Q   M++ L  IN +F++L+T 
Sbjct: 1237 LNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTM 1296

Query: 1523 EFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRI 1582
            E +LKL++ R +YFTI WNIFDF+VVI SI G+ L   +  Y V P+L ++I L+RI  +
Sbjct: 1297 ECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILLSRIIHM 1356

Query: 1583 LRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFN 1642
            LRL KG K    L+  LM+SLPAL NI LL+FLVMFIYA+FGM NFAYVKKEAGI+D+ N
Sbjct: 1357 LRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSN 1416

Query: 1643 FETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFF 1702
            FETFGNSM+CLFQ+   AGWDG+L  I NS   DCDPD I+PG+ V+GDCGNPSVGIF+F
Sbjct: 1417 FETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYF 1476

Query: 1703 VSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFS 1762
            VSYI+IS+L++VNMYI V++E  ++A+++  + LSEDDF  F++VW++FDPD TQ+I+ S
Sbjct: 1477 VSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSS 1536

Query: 1763 KLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALR 1822
            KLSDFAAALDPPL +AKPNK QLIA+DLPM  GDRIHCLDIL AFTKRV+G+   M+ + 
Sbjct: 1537 KLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVV 1596

Query: 1823 IQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRLKNIS 1875
             ++E  F+ +NP K++ EPITTTLKRKQE VSA IIQR ++ Y L++  KN S
Sbjct: 1597 SEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDKNTS 1649



 Score =  418 bits (1075), Expect = e-116
 Identities = 219/458 (47%), Positives = 296/458 (64%), Gaps = 28/458 (6%)

Query: 5   LLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFI 64
           +L  P P+    FT+ES   I++  A       K   ++ +E   KP  DLE GK LPFI
Sbjct: 1   MLASPEPKGLVPFTKESFELIKQHIA-------KTHNEDHEEEDLKPTPDLEVGKKLPFI 53

Query: 65  YGDIPPEMVSEPLEDLDPYYINKK-TFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIK 123
           YG++   MVSEPLED+DPYY  KK TFIV+NK + IFRF+A S L  L+P N +R+  IK
Sbjct: 54  YGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIK 113

Query: 124 ILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDF 183
           +LVH  F + I+ ++L +CVFM+L+N P W   +E T  GIYTFE L+K+ ARG     F
Sbjct: 114 VLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSF 173

Query: 184 TFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS 243
           +FL DPWNWLDFSV V   +  +  L  +  L+T R LR LK I +  GLK++VG LI  
Sbjct: 174 SFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHC 233

Query: 244 VKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNG 303
           +K+L  V+ILT+F LS+F+LIG+ LFMGNL++KC +WP                  + N 
Sbjct: 234 LKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQE----------------NENE 277

Query: 304 TFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGY 363
           T  N T + +    YI +  +FY L+G++  LLCGN +DAGQCPEGY+CVKAG NP+ G+
Sbjct: 278 TLHNRTGNPY----YIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGF 333

Query: 364 TSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVV 423
           T+FD+F WA  +LFRLM QDY E LY   L A+GK YMIFFV+V FL SFY+ +L L ++
Sbjct: 334 TNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGIL 393

Query: 424 AMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQA 461
           AMAYEE+ Q   E +++ E +FQQ  ++L++  E  +A
Sbjct: 394 AMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEA 431



 Score =  140 bits (353), Expect = 1e-32
 Identities = 154/689 (22%), Positives = 293/689 (42%), Gaps = 147/689 (21%)

Query: 1146 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1205
            +R+T   ++ H +F+ FI+  +L+    ++  ++   +     T+L     ++T+  +++
Sbjct: 107  IRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLG----IYTFEILVK 162

Query: 1206 MLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRA 1265
            +  + V  G  ++  + W WLDF +    ++      + YS L  I +L+T R LR L+ 
Sbjct: 163  LFARGVWAGSFSFLGDPWNWLDFSVTVFEVI------IRYSPLDFIPTLQTARTLRILKI 216

Query: 1266 LSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH----------- 1314
            +   +G++ +V  L+  +  ++ V+++ L F  IFS++G+ LF G   H           
Sbjct: 217  IPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENEN 276

Query: 1315 -CVNMTTGNMFDISDVNNLSDCQALGKQARWKN-------------VK---------VNF 1351
              ++  TGN + I +  N    +         N             VK          NF
Sbjct: 277  ETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNF 336

Query: 1352 DNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTL 1411
            D+ G    AL ++   + + +++Y          Q +Y       ++FV+     SF+  
Sbjct: 337  DSFGWALFALFRLMA-QDYPEVLYH---------QILYASGKVYMIFFVVVSFLFSFYMA 386

Query: 1412 NLFIGVIIDNFNQQKKKFGG----------------QDIFMTEEQKKYYNAMKKLGS--- 1452
            +LF+G++   + ++K++ G                 Q+   T+E K     MKK      
Sbjct: 387  SLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPIST 446

Query: 1453 ------------------KKPQKPIPRPANKFQGMVF------------DFVTRQVF--- 1479
                              +K +K  P    KF                 +FV R +    
Sbjct: 447  DTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPF 506

Query: 1480 -DISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHY-YFT 1537
             D+ ++I I LN+  + +E     K    +L+  NLVFI +FT E + K++++  Y YF 
Sbjct: 507  TDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQ 566

Query: 1538 IGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLF 1597
            +GWNIFD ++V   ++ + LA +            ++RL R+ RI +L K     + L++
Sbjct: 567  VGWNIFDSMIVFHGLIELCLANVAG--------MALLRLFRMLRIFKLGKYWPTFQILMW 618

Query: 1598 ALMMSLPALFNIGLLLFLVMFIYAIFGMSNF--------AYVKKEAGIDDMFNFETFGNS 1649
            +L  S  AL ++ LLLF  +F  A FGM  F         ++ K+  +   ++   F +S
Sbjct: 619  SLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQL-PRWHMHDFFHS 677

Query: 1650 MICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIIS 1709
             + +F+I      + L          DC             +    S  I F++  I+I 
Sbjct: 678  FLNVFRILCGEWVETLW---------DC------------MEVAGQSWCIPFYLMVILIG 716

Query: 1710 FLVVVNMYIAVILENFSVATEESAEPLSE 1738
             L+V+ +++A++  +FS   + +AE  +E
Sbjct: 717  NLLVLYLFLALV-SSFSSCKDVTAEENNE 744



 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 66/269 (24%), Positives = 119/269 (44%), Gaps = 32/269 (11%)

Query: 19  RESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFIYGDIPPEMVSEPLE 78
           ++ +  I K+  E K ++  KE    +E        +E  K  P     I  +   + LE
Sbjct: 401 KQRVGEISKKI-EPKFQQTGKELQEGNETDEAKTIQIEMKKRSP-----ISTDTSLDVLE 454

Query: 79  DLDPYYINKKTFIVMNKGKAI-----FRFSATSALYILTPLNPVRKIAIKILVHSLFS-- 131
           D    +  +     + K K I     ++F+ T  ++  +P     K  +  ++ + F+  
Sbjct: 455 DATLRHKEE-----LEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDL 509

Query: 132 MLIMCTILTNCVFMTLSNPP-----DWTKNV-EYTFTGIYTFESLIKILARGFCLEDFTF 185
            LI+C IL  C F+TL + P     +   N+    F GI+T E + KI+A    +  + +
Sbjct: 510 FLIICIILNVC-FLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIA----MHPYGY 564

Query: 186 LRDPWNWLDFSVIVMAYVTE--FVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS 243
            +  WN  D S+IV   + E    ++  ++ LR FR+LR  K     P  + ++ +L  S
Sbjct: 565 FQVGWNIFD-SMIVFHGLIELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNS 623

Query: 244 VKKLSDVMILTVFCLSVFALIGLQLFMGN 272
              L D+++L    +   A  G++LF  N
Sbjct: 624 WVALKDLVLLLFTFIFFSAAFGMKLFGKN 652



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 47/184 (25%), Positives = 86/184 (46%), Gaps = 17/184 (9%)

Query: 117  VRKIAIKILVHSLFSMLI-MCTILTNCVFMTLSNPPDWTKNV----EYT---FTGIYTFE 168
            +RK   KI+ ++ F   I + T+L+           D  K +    EY    FT I+  E
Sbjct: 923  IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982

Query: 169  SLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGN--VSALRTFRVLRALKT 226
             L+K +A GF      +  + W  LDF V+V+ +    +      +  L + + LR L+ 
Sbjct: 983  MLLKWMAYGFK----AYFSNGWYRLDF-VVVIVFCLSLIGKTREELKPLISMKFLRPLRV 1037

Query: 227  ISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSA 286
            +S    +K +V ALI++     +V ++ +    +F+++G+ LF G    +C+  P S   
Sbjct: 1038 LSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRF-YECID-PTSGER 1095

Query: 287  FETN 290
            F ++
Sbjct: 1096 FPSS 1099



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 34/153 (22%), Positives = 78/153 (50%), Gaps = 11/153 (7%)

Query: 707 IVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMD 766
           +++ PF  L I I ++++ +FM++ + P   ++  VL        GI+T E+++K+ A  
Sbjct: 114 VLVHPFFQLFILISVLIDCVFMSLTNLP---KWRPVL---ENTLLGIYTFEILVKLFARG 167

Query: 767 ----PYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNML 822
                + +  + WN  D  +    ++ +  S ++ +  L++ R LR+ K+      L  L
Sbjct: 168 VWAGSFSFLGDPWNWLDFSVTVFEVI-IRYSPLDFIPTLQTARTLRILKIIPLNQGLKSL 226

Query: 823 IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 855
           + ++ + +  L  + ++    + IF+++GM LF
Sbjct: 227 VGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLF 259



 Score = 37.4 bits (85), Expect = 0.14
 Identities = 24/87 (27%), Positives = 52/87 (59%), Gaps = 4/87 (4%)

Query: 369 FSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMI-FFVLVIFLGSFYLVNLILAVVAMAY 427
           F  +FL++FR++  ++ E L+   +  AG+++ I F+++VI +G+  ++ L LA+V+ ++
Sbjct: 674 FFHSFLNVFRILCGEWVETLWDC-MEVAGQSWCIPFYLMVILIGNLLVLYLFLALVS-SF 731

Query: 428 EEQNQATLEEAEQKEAEFQQMLEQLKK 454
                 T EE  + +   Q  + ++KK
Sbjct: 732 SSCKDVTAEENNEAK-NLQLAVARIKK 757


>gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo
            sapiens]
          Length = 1791

 Score = 1292 bits (3344), Expect = 0.0
 Identities = 710/1360 (52%), Positives = 927/1360 (68%), Gaps = 102/1360 (7%)

Query: 558  SLLSIRGSLFSPRR-----NSKTSIFSFRGRAKDV--GSENDFADDEHSTFEDSESRRDS 610
            SL S+  S F+P++     N K   F  R   KD   GS++D         ED + +   
Sbjct: 444  SLTSLETSYFTPKKRKLFGNKKRKSFFLRESGKDQPPGSDSD---------EDCQKKPQL 494

Query: 611  LFVPHRHGERRNSNGTTTETEVRKRRLSSYQISMEMLE---DSSGRQRAVSIASILTNTM 667
            L                     + +RLS   +S++  +   D   RQRA+S  SILT TM
Sbjct: 495  L--------------------EQTKRLSQ-NLSLDHFDEHGDPLQRQRALSAVSILTITM 533

Query: 668  EELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLF 727
            +E E+S++ C PC    A+ +L+W+CC  WL VK ++  ++ DPF +LAITICI++NT+F
Sbjct: 534  KEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVF 593

Query: 728  MAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSL 787
            +AMEH+ M   F  +L +GNLVFT IF AEM LKIIA+DPY+YF+ GWNIFD I+  LS 
Sbjct: 594  LAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSF 653

Query: 788  MELGLSNVEGLS--VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVF 845
             ++    ++  S   LRSFR+LRVFKLAKSWPTLN LIKIIGNSVGALG+LT+VL I++F
Sbjct: 654  ADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIF 713

Query: 846  IFAVVGMQLFGKSY------KECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETM 899
            IF+VVGMQLFG+S+      K C         L  WHM DF+HSFL+VFR+LCGEWIE M
Sbjct: 714  IFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGEWIENM 773

Query: 900  WDCMEVAG--QTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAAT-DDDNEMNNLQ 956
            W+CM+ A    ++C+IVF+L+ VIG LVVLNLF+ALLL+SFS++      + +     +Q
Sbjct: 774  WECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQ 833

Query: 957  IAVGRMQKGIDYVKNKMRECFQKAFFRK---PKVIEIHEGNKIDS------CMSNNTGIE 1007
            +A+ R ++   +V++ + E F   + RK   P+  E+  G    S       M    G E
Sbjct: 834  LALDRFRRAFCFVRHTL-EHFCHKWCRKQNLPQQKEVAGGCAAQSKDIIPLVMEMKRGSE 892

Query: 1008 ISKELNYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGES------ 1061
              +EL  L     T       + +     +E+D      + +  +T P    ++      
Sbjct: 893  TQEELGILTSVPKTLGVRHDWTWLAPLAEEEDDVEFSGEDNAQRITQPEPEQQAYELHQE 952

Query: 1062 -------DFENLNTEEFSSESE---LEESKEKLNATSS-SEGSTVDVVLPREGEQAETEP 1110
                     +++  + FS +     +++ ++K + TS  SE ST+D+   ++G     E 
Sbjct: 953  NKKPTSQRVQSVEIDMFSEDEPHLTIQDPRKKSDVTSILSECSTIDL---QDGFGWLPEM 1009

Query: 1111 EEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLS 1170
                +PE C  +G    FP C V   +    IWWNLRKTCY IV+H+WFE+FI+F+ILLS
Sbjct: 1010 VPKKQPERCLPKGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVILLS 1069

Query: 1171 SGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLI 1230
            SGAL FED+++E +  I+ +L   D +FT+IFILEM+LKWVA+GF  YFT+AWC LDF+I
Sbjct: 1070 SGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFII 1129

Query: 1231 VDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1290
            V VS+ +L+        L  +KS RTLRALRPLRALS+FEGM+VVVNAL+GAIP+I+NVL
Sbjct: 1130 VIVSVTTLI-------NLMELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVL 1182

Query: 1291 LVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNNLSDCQALGKQARWKNVKVN 1350
            LVCLIFWL+F I+GV  F+GKF  C+N  T ++ + + + N S C++      W N KVN
Sbjct: 1183 LVCLIFWLVFCILGVYFFSGKFGKCIN-GTDSVINYTIITNKSQCES--GNFSWINQKVN 1239

Query: 1351 FDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFT 1410
            FDNVG  YLALLQVATFKGWMDI+YAAVDS + + QP +E N   Y+YFV+FIIFGSFFT
Sbjct: 1240 FDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFT 1299

Query: 1411 LNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMV 1470
            LNLFIGVIIDNFNQQ+KK GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG+V
Sbjct: 1300 LNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLV 1359

Query: 1471 FDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVS 1530
            FD VT Q+FDI I+ LI LNM++MM E+ +Q K M  +L  +N VF+V+FT E ++K+ +
Sbjct: 1360 FDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFA 1419

Query: 1531 LRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFV--SPTLFRVIRLARIGRILRLIKG 1588
            LR YYFT GWN+FD VVV+LSIV   ++ +  +  +   PTLFR++RLARIGRILRL++ 
Sbjct: 1420 LRQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRA 1479

Query: 1589 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGN 1648
            A+GIRTLLFALMMSLP+LFNIGLLLFL+MFIYAI GM+ F+ V  E+GIDD+FNF+TF +
Sbjct: 1480 ARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFAS 1539

Query: 1649 SMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIII 1708
            SM+CLFQI+TSAGWD LL+P+L S    C        +S   +C  P +   +FVSYIII
Sbjct: 1540 SMLCLFQISTSAGWDSLLSPMLRS-KESC--------NSSSENCHLPGIATSYFVSYIII 1590

Query: 1709 SFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFA 1768
            SFL+VVNMYIAVILENF+ ATEES +PL EDDF++FYEVWEKFDP+ATQFI++S LSDFA
Sbjct: 1591 SFLIVVNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDFA 1650

Query: 1769 AALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDR 1828
             AL  PL +AKPNK Q + MDLPMVS DR+HC+DILFAFT RVLG S  +D+++  ME++
Sbjct: 1651 DALPEPLRVAKPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLGGSDGLDSMKAMMEEK 1710

Query: 1829 FMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLK 1868
            FM +NP K  YEPI TT KRK+EE  AAIIQ+ FR Y++K
Sbjct: 1711 FMEANPLKKLYEPIVTTTKRKEEERGAAIIQKAFRKYMMK 1750



 Score =  409 bits (1052), Expect = e-113
 Identities = 239/543 (44%), Positives = 318/543 (58%), Gaps = 54/543 (9%)

Query: 9   PGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFIYGDI 68
           P   +FR FT +SLAAIEKR A +K KK  K+Q  +   +P+P  DL+A + LP +YGDI
Sbjct: 11  PDERNFRPFTSDSLAAIEKRIAIQKEKKKSKDQTGEVP-QPRPQLDLKASRKLPKLYGDI 69

Query: 69  PPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHS 128
           P E++ +PLEDLDP+Y N KTF+V+N+ + I+RFSA  AL+I  P N +R +AI++ VHS
Sbjct: 70  PRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHS 129

Query: 129 LFSMLIMCTILTNCVFMTLSNPPDWTKN----VEYTFTGIYTFESLIKILARGFCLEDFT 184
           LFSM I+ T++ NCVFM      +   N     E  FTGIY FE+LIKILARGF L++F+
Sbjct: 130 LFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFS 189

Query: 185 FLRDPWNWLDFSVIVMAYVTEFVDLG-NVSALRTFRVLRALKTISVIPGLKTIVGALIQS 243
           FLRDPWNWLD  VI +A V+    +   +  LRTFRV RALK ISV+  LK IVGAL++S
Sbjct: 190 FLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRS 249

Query: 244 VKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNG 303
           VKKL +V+ILT FCLS+FAL+G QLFMG+L  KC+     D    +N  +Y         
Sbjct: 250 VKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCIS---RDCKNISNPEAY--------- 297

Query: 304 TFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGY 363
                             D  F   +   +  +CG       C   Y C     NP+Y Y
Sbjct: 298 ------------------DHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNY 339

Query: 364 TSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVV 423
           T+FD F W+FL++FRLMTQD WE LYQ TLR  G   + FF++VIFLGSFYL+NL LAVV
Sbjct: 340 TNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVV 399

Query: 424 AMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGELLE 483
            MAYEEQN+    E E KE  FQ+  + LK+++E   A+              G+     
Sbjct: 400 TMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEKEALVAM--------------GIDRSSL 445

Query: 484 SSSEASKLSSKSAKEWRNRRKK----RRQREHLEGNNKGERDSFPKSESEDSVKRSSFLF 539
           +S E S  + K  K + N+++K    R   +     +  + D   K +  +  KR S   
Sbjct: 446 TSLETSYFTPKKRKLFGNKKRKSFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNL 505

Query: 540 SMD 542
           S+D
Sbjct: 506 SLD 508



 Score =  100 bits (250), Expect = 1e-20
 Identities = 78/338 (23%), Positives = 151/338 (44%), Gaps = 50/338 (14%)

Query: 1145 NLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFIL 1204
            ++R     +  H+ F  FI+  ++++   +A        + +     + A+ VFT I+I 
Sbjct: 117  SIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPA----KNSNSNNTDIAECVFTGIYIF 172

Query: 1205 EMLLKWVAYGFQ----TYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1260
            E L+K +A GF     ++  + W WLD +++ +++VS +           +  LRT R  
Sbjct: 173  EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-----KLLPLRTFRVF 227

Query: 1261 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF------YH 1314
            R L+A+S    ++V+V AL+ ++  ++NV+++      IF+++G  LF G          
Sbjct: 228  RALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRD 287

Query: 1315 CVNMTTGNMFD--ISDVNNLSDCQALG---------KQARWKNVKV-------NFDNVGA 1356
            C N++    +D       N  + +  G          Q   K+ K+       NFDN G 
Sbjct: 288  CKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGW 347

Query: 1357 GYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIG 1416
             +LA+ ++ T   W  +            Q +    LY   +F++ I  GSF+ +NL + 
Sbjct: 348  SFLAMFRLMTQDSWEKLYQ----------QTLRTTGLYSVFFFIVVIFLGSFYLINLTLA 397

Query: 1417 VIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKK 1454
            V+   + +Q K    +   +  ++K +  A + L  +K
Sbjct: 398  VVTMAYEEQNKNVAAE---IEAKEKMFQEAQQLLKEEK 432



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 81/338 (23%), Positives = 141/338 (41%), Gaps = 88/338 (26%)

Query: 117  VRKIAIKILVHSLFSMLIMCTILTNC---VF--MTLSNPPDWTKNVEYT---FTGIYTFE 168
            +RK   +I+ HS F   I+  IL +    +F  + L N P   + +  T   FT I+  E
Sbjct: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104

Query: 169  SLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTIS 228
             ++K +A GF      +    W  LDF +IV+  VT  ++L  + + RT R LR L+ +S
Sbjct: 1105 MVLKWVAFGFG----KYFTSAWCCLDF-IIVIVSVTTLINLMELKSFRTLRALRPLRALS 1159

Query: 229  VIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFE 288
               G+K +V ALI ++  + +V+++ +    VF ++G+  F G    KC+          
Sbjct: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF-GKCI---------- 1208

Query: 289  TNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPE 348
                   NGT     + +N T+ T                             +  QC  
Sbjct: 1209 -------NGT----DSVINYTIIT-----------------------------NKSQCES 1228

Query: 349  GYICVKAGRNPNYGY----TSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYM--- 401
            G          N+ +     +FD    A+L+L ++ T   W ++    + +  K      
Sbjct: 1229 G----------NFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEF 1278

Query: 402  -------IFFVLVIFLGSFYLVNLILAVVAMAYEEQNQ 432
                   I+FV+ I  GSF+ +NL + V+   + +Q +
Sbjct: 1279 ESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQK 1316



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 61/275 (22%), Positives = 122/275 (44%), Gaps = 59/275 (21%)

Query: 721 IVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIA----MDPYYYFQEGWN 776
           +++N +FMA    P     S+   +   VFTGI+  E ++KI+A    +D + + ++ WN
Sbjct: 139 VIINCVFMATG--PAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWN 196

Query: 777 IFDGIIVSLSLMELGLSNVEGLSV----LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGA 832
             D I++ ++++    S + G+++    LR+FR+ R  K       L +++  +  SV  
Sbjct: 197 WLDSIVIGIAIV----SYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKK 252

Query: 833 LGNLTLVLAIIVFIFAVVGMQLF------------------GKSYKEC------------ 862
           L N+ ++    + IFA+VG QLF                   ++Y  C            
Sbjct: 253 LVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKM 312

Query: 863 --------VCKINDDCTLPR-------WHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAG 907
                    C I  +C   +        + ++F  SFL +FR++  +  E ++       
Sbjct: 313 CGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTT 372

Query: 908 QTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDN 942
               +  F++V+ +G+  ++NL LA++  ++   N
Sbjct: 373 GLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQN 407



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 44/174 (25%), Positives = 84/174 (48%), Gaps = 22/174 (12%)

Query: 113  PLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLS--NPPDWTKNV----EYTFTGIYT 166
            PLN  + +   I+   +F ++I+  I+ N + M     N P   K++     + F  I+T
Sbjct: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFT 1410

Query: 167  FESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVD-LGN----------VSAL 215
             E LIKI    F L  + F  + WN  D  V++++ V+  +  L N             +
Sbjct: 1411 LECLIKI----FALRQYYF-TNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIV 1465

Query: 216  RTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
            R  R+ R L+ +    G++T++ AL+ S+  L ++ +L    + ++A++G+  F
Sbjct: 1466 RLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWF 1519



 Score = 58.5 bits (140), Expect = 6e-08
 Identities = 44/166 (26%), Positives = 78/166 (46%), Gaps = 21/166 (12%)

Query: 117 VRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPP-----DWTKNV-EYTFTGIYTFESL 170
           V+K+   ++      + I   I+ N VF+ + +       +   N+    FT I+  E  
Sbjct: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625

Query: 171 IKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSA-------LRTFRVLRA 223
           +KI+A    L+ + + R  WN  D  V +++    F D+ N          LR+FRVLR 
Sbjct: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLS----FADVMNCVLQKRSWPFLRSFRVLRV 677

Query: 224 LKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
            K     P L T++  +  SV  L  + ++ V  + +F+++G+QLF
Sbjct: 678 FKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 723



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 67/368 (18%), Positives = 132/368 (35%), Gaps = 97/368 (26%)

Query: 1462 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFT 1521
            P N  + +        +F + I+  + +N V M              ++    VF  ++ 
Sbjct: 114  PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGIYI 171

Query: 1522 GEFVLKLVS----LRHYYFTIG-WNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRL 1576
             E ++K+++    L  + F    WN  D +V+ ++IV       I+           +R 
Sbjct: 172  FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK--------LLPLRT 223

Query: 1577 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-------- 1628
             R+ R L+ I     ++ ++ AL+ S+  L N+ +L F  + I+A+ G   F        
Sbjct: 224  FRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKC 283

Query: 1629 ----------------AYVKKEAGID----------------------------DMFNFE 1644
                             + KKE   +                            +  NF+
Sbjct: 284  ISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFD 343

Query: 1645 TFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVS 1704
             FG S + +F++ T   W+ L    L +                          +FFF+ 
Sbjct: 344  NFGWSFLAMFRLMTQDSWEKLYQQTLRT---------------------TGLYSVFFFIV 382

Query: 1705 YIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKL 1764
             I +    ++N+ +AV+    ++A EE  + ++ +      E  EK   +A Q ++  K 
Sbjct: 383  VIFLGSFYLINLTLAVV----TMAYEEQNKNVAAE-----IEAKEKMFQEAQQLLKEEKE 433

Query: 1765 SDFAAALD 1772
            +  A  +D
Sbjct: 434  ALVAMGID 441



 Score = 35.4 bits (80), Expect = 0.55
 Identities = 39/136 (28%), Positives = 61/136 (44%), Gaps = 28/136 (20%)

Query: 358  NPNYGYT---SFDTFSWAFLSLFRLMTQDYWENLYQLTLRA---------------AGKT 399
            NP  G     +F TF+ + L LF++ T   W++L    LR+                  +
Sbjct: 1523 NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATS 1582

Query: 400  YMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQK--EAEFQQMLEQLKKQQE 457
            Y + ++++ FL    +VN+ +AV+    E  N AT EE+E    E +F    E  +K   
Sbjct: 1583 YFVSYIIISFL---IVVNMYIAVI---LENFNTAT-EESEDPLGEDDFDIFYEVWEKFDP 1635

Query: 458  EAQAVAAASAASRDFS 473
            EA      SA S DF+
Sbjct: 1636 EATQFIKYSALS-DFA 1650


>gi|239748090 PREDICTED: similar to sodium channel, voltage-gated,
            type V, alpha (long QT syndrome 3) [Homo sapiens]
          Length = 1637

 Score = 1011 bits (2614), Expect = 0.0
 Identities = 538/847 (63%), Positives = 623/847 (73%), Gaps = 66/847 (7%)

Query: 926  VLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRE-CFQKAFFRK 984
            VLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ R+Q+G+ +VK    + C      R 
Sbjct: 631  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690

Query: 985  PKVIEIHEGNKIDSCMSNNTGI------EISKELNYLRDGNGTTSGVGTGSSVEKYVIDE 1038
             K   +    ++ SC++           ++       R   G   G GT    E      
Sbjct: 691  QKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEP----- 745

Query: 1039 NDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSEGSTVDVV 1098
                         V VPIAV ESD ++   +E +S    EES ++  +   S G      
Sbjct: 746  -------------VCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGP----- 787

Query: 1099 LPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNW 1158
                    E  P+     +   T          + S  +   +  W          E   
Sbjct: 788  --------EAPPDSRTWSQVSATASSE-----AEASASQADWRQQWKAEPQAPGCGE--- 831

Query: 1159 FETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTY 1218
                            AFEDIY+E+RKTIK +LEYADK+FTY+F+LEMLLKWVAYGF+ Y
Sbjct: 832  ----------------AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKY 875

Query: 1219 FTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNA 1278
            FTNAWCWLDFLIVDVSLVSLVAN LG++E+G IKSLRTLRALRPLRALSRFEGMRVVVNA
Sbjct: 876  FTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNA 935

Query: 1279 LVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNM-FDISDVNNLSDCQA 1337
            LVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  C+N T G++  + + VNN S C++
Sbjct: 936  LVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCES 995

Query: 1338 LGKQAR--WKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYM 1395
            L       W  VKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSR  + QP +E NLYM
Sbjct: 996  LNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYM 1055

Query: 1396 YLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKP 1455
            Y+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKKLGSKKP
Sbjct: 1056 YIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKP 1115

Query: 1456 QKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLV 1515
            QKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTMMVETDDQ      +L++INL+
Sbjct: 1116 QKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLL 1175

Query: 1516 FIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIR 1575
            F+ +FTGE ++KL +LRHYYFT  WNIFDFVVVILSIVG  L+++I+KYF SPTLFRVIR
Sbjct: 1176 FVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIR 1235

Query: 1576 LARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEA 1635
            LARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGM+NFAYVK EA
Sbjct: 1236 LARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEA 1295

Query: 1636 GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNP 1695
            GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP CDP T+   +  +GDCG+P
Sbjct: 1296 GIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDP-TLPNSNGSRGDCGSP 1354

Query: 1696 SVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDA 1755
            +VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EPLSEDDF+MFYE+WEKFDP+A
Sbjct: 1355 AVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEA 1414

Query: 1756 TQFIEFS 1762
            TQFIE+S
Sbjct: 1415 TQFIEYS 1421



 Score =  668 bits (1724), Expect = 0.0
 Identities = 364/616 (59%), Positives = 435/616 (70%), Gaps = 63/616 (10%)

Query: 6   LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDN----DDENKPKPNSDLEAGKNL 61
           L+P G  SFR FTRESLAAIEKR AE++A+     Q++     +E  P+P  DL+A K L
Sbjct: 5   LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 62  PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIA 121
           P +YG+ P E++ EPLEDLDP+Y  +KTFIV+NKGK IFRFSAT+ALY+L+P +P+R+ A
Sbjct: 65  PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 122 IKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 181
           +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 182 DFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
            FTFLRDPWNWLDFSVI+MAY TEFVDLGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 185 AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244

Query: 242 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDS 301
           QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+        
Sbjct: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTAL------- 287

Query: 302 NGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRN 358
           NGT  +V      W+    Y+ D  ++ + +G  D LLCGN SDAG CPEGY C+KAG N
Sbjct: 288 NGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGEN 347

Query: 359 PNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNL 418
           P++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYLVNL
Sbjct: 348 PDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNL 407

Query: 419 ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGL 478
           ILAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                 I G+
Sbjct: 408 ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALT--------------IRGV 453

Query: 479 GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538
             +  SS E S L+  ++ E R++R+KR       G  +   D  PKS+SED  +  + L
Sbjct: 454 DTVSRSSLEMSPLAPVNSHERRSKRRKRMS----SGTEECGEDRLPKSDSEDGPRAMNHL 509

Query: 539 FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598
               G   TS K                    R+S+ SIF+FR R  D+GSE DFADDE+
Sbjct: 510 SLTRGLSRTSMKP-------------------RSSRGSIFTFRRR--DLGSEADFADDEN 548

Query: 599 STFEDSESRRDSLFVP 614
           ST  +SES   SL VP
Sbjct: 549 STAGESESHHTSLLVP 564



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 85/350 (24%), Positives = 152/350 (43%), Gaps = 73/350 (20%)

Query: 1146 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1205
            +R+    I+ H+ F   I+  IL +   +A  D             +Y +  FT I+  E
Sbjct: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171

Query: 1206 MLLKWVAYGFQ----TYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALR 1261
             L+K +A GF     T+  + W WLDF ++      ++A    + +LG + +LRT R LR
Sbjct: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225

Query: 1262 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH-CV---- 1316
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   H CV    
Sbjct: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285

Query: 1317 --NMTTGNM--------------------------FDISDVNNLSDCQALGKQARWKNVK 1348
              N T G++                           D+    N SD     +  R     
Sbjct: 286  ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAG 345

Query: 1349 VN-------FDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVI 1401
             N       FD+    +LAL ++ T   W  +    + S            +YM ++F++
Sbjct: 346  ENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFML 395

Query: 1402 FIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE-QKKYYNAMKKL 1450
             I  GSF+ +NL + V+   + +Q +      I  TEE +K++  AM+ L
Sbjct: 396  VIFLGSFYLVNLILAVVAMAYEEQNQ----ATIAETEEKEKRFQEAMEML 441



 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 70/273 (25%), Positives = 132/273 (48%), Gaps = 40/273 (14%)

Query: 707  IVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMD 766
            IV     D+ I   I LN + M +E    + +  ++L   NL+F  IFT E ++K+ A+ 
Sbjct: 1133 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1192

Query: 767  PYYYFQEGWNIFDGIIVSLSLMELGLSNVEG--------LSVLRSFRLLRVFKLAKSWPT 818
             +YYF   WNIFD ++V LS++   LS++            V+R  R+ R+ +L +    
Sbjct: 1193 -HYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1251

Query: 819  LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMN 878
            +  L+  +  S+ AL N+ L+L +++FI+++ GM  F  +Y +    I+D      ++  
Sbjct: 1252 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF--AYVKWEAGIDD-----MFNFQ 1304

Query: 879  DFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC--------------------LIVFMLV 918
             F +S L +F++      + +   +   G   C                    ++ F   
Sbjct: 1305 TFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTY 1364

Query: 919  MVIGNLVVLNLFLALLLSSFSSDNLAATDDDNE 951
            ++I  L+V+N+++A++L +FS     AT++  E
Sbjct: 1365 IIISFLIVVNMYIAIILENFS----VATEESTE 1393



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 64/279 (22%), Positives = 120/279 (43%), Gaps = 53/279 (18%)

Query: 161  FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVT------EFVDLGNVSA 214
            FT ++  E L+K +A GF      +  + W WLDF ++ ++ V+       F ++G + +
Sbjct: 855  FTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 910

Query: 215  LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 274
            LRT R LR L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   
Sbjct: 911  LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF- 969

Query: 275  NKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDP 334
             +C+     D     N T   N    S    +N+T   +  K  +  D+           
Sbjct: 970  GRCINQTEGD--LPLNYTIVNN---KSQCESLNLTGELYWTKVKVNFDN----------- 1013

Query: 335  LLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWE-NLYQLTL 393
                          GY+ +         +  +    +A +       Q  WE NLY    
Sbjct: 1014 -----------VGAGYLALLQVAT----FKGWMDIMYAAVDSRGYEEQPQWEYNLYM--- 1055

Query: 394  RAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQ 432
                    I+FV+ I  GSF+ +NL + V+   + +Q +
Sbjct: 1056 -------YIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1087



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 49/237 (20%), Positives = 105/237 (44%), Gaps = 39/237 (16%)

Query: 742  VLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMEL-----GLSNVE 796
            +L   + +FT +F  EM+LK +A     YF   W   D +IV +SL+ L     G + + 
Sbjct: 847  LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 906

Query: 797  GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 856
             +  LR+ R LR  +    +  + +++  +  ++ ++ N+ LV  I   IF+++G+ LF 
Sbjct: 907  PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 966

Query: 857  KSYKECVCKINDDC------------------------TLPRWHMNDFFHSFLIVFRVLC 892
              +  C+ +   D                         T  + + ++    +L + +V  
Sbjct: 967  GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1026

Query: 893  GE-WIETMWDCMEVAG---------QTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 939
             + W++ M+  ++  G              I F++ ++ G+   LNLF+ +++ +F+
Sbjct: 1027 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1083



 Score = 57.8 bits (138), Expect = 1e-07
 Identities = 45/164 (27%), Positives = 81/164 (49%), Gaps = 16/164 (9%)

Query: 707 IVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIA-- 764
           I++    ++ I   I+ N +FMA    P   ++          FT I+T E ++KI+A  
Sbjct: 127 ILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYTFESLVKILARG 180

Query: 765 --MDPYYYFQEGWNIFDG--IIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLN 820
             +  + + ++ WN  D   II++ +   + L NV   S LR+FR+LR  K       L 
Sbjct: 181 FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNV---SALRTFRVLRALKTISVISGLK 237

Query: 821 MLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 863
            ++  +  SV  L ++ ++    + +FA++G+QLF G    +CV
Sbjct: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV 281



 Score = 48.9 bits (115), Expect = 5e-05
 Identities = 40/172 (23%), Positives = 73/172 (42%), Gaps = 20/172 (11%)

Query: 113  PLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYT------FTGIYT 166
            PLN  +     I+    F + IM  I  N V M +       + +         F  I+T
Sbjct: 1122 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT 1181

Query: 167  FESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYV---------TEFVDLGNVSALRT 217
             E ++K+ A    L  + F    WN  DF V++++ V           F        +R 
Sbjct: 1182 GECIVKLAA----LRHYYFTNS-WNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRL 1236

Query: 218  FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
             R+ R L+ I    G++T++ AL+ S+  L ++ +L    + ++++ G+  F
Sbjct: 1237 ARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF 1288



 Score = 37.7 bits (86), Expect = 0.11
 Identities = 22/95 (23%), Positives = 48/95 (50%), Gaps = 6/95 (6%)

Query: 878 NDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSS 937
           + F  +FL +FR++  +  E ++     +   + +I FMLV+ +G+  ++NL LA++  +
Sbjct: 356 DSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMA 415

Query: 938 FSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNK 972
           +   N A   +  E         R Q+ ++ +K +
Sbjct: 416 YEEQNQATIAETEEKEK------RFQEAMEMLKKE 444



 Score = 32.3 bits (72), Expect = 4.7
 Identities = 41/164 (25%), Positives = 63/164 (38%), Gaps = 36/164 (21%)

Query: 365  SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTY---------------------MIF 403
            +F TF+ + L LF++ T   W+ L    L   G  Y                     ++F
Sbjct: 1302 NFQTFANSMLCLFQITTSAGWDGLLSPILN-TGPPYCDPTLPNSNGSRGDCGSPAVGILF 1360

Query: 404  FVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQ-KEAEFQQMLEQLKKQQEEAQAV 462
            F   I +    +VN+ +A++    E  + AT E  E   E +F    E  +K   EA   
Sbjct: 1361 FTTYIIISFLIVVNMYIAII---LENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQF 1417

Query: 463  AAASAASR-----DFSGIGG-----LGELLESSSEASKLSSKSA 496
               S  +R     D S  G      L  LL    E ++L+S +A
Sbjct: 1418 IEYSCGTRFNCPSDISPSGNPIFVDLHALLSRLGELTELASPAA 1461


>gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I
            subunit isoform b [Homo sapiens]
          Length = 2188

 Score =  343 bits (881), Expect = 7e-94
 Identities = 212/622 (34%), Positives = 344/622 (55%), Gaps = 36/622 (5%)

Query: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1206
            R  C +I+ H  F+  ++  I L+   +A E   IE   T +  L  ++ +FT IF+ EM
Sbjct: 1125 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1184

Query: 1207 LLKWVA----YGFQTYFTNAWCWLDFLIVDVSLVSLV---ANALGYSELGAIKSLRTLRA 1259
             LK V+    +G Q Y  ++W  LD  +V VS++ +V   A+A G   LG ++ LR LR 
Sbjct: 1185 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1244

Query: 1260 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1319
            LRPLR +SR  G+++VV  L+ ++  I N++L+C  F++IF I+GV LF GKFYHC+ + 
Sbjct: 1245 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVD 1304

Query: 1320 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1379
            T N      + N SDC A     RW + K NFDN+G   ++L  +A+  GW++IMY  +D
Sbjct: 1305 TRN------ITNRSDCMA--ANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLD 1356

Query: 1380 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1439
            +  V  QPV   N +M LYF+ F++  SFF LN+F+GV+++NF++ ++    ++    EE
Sbjct: 1357 AVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE 1416

Query: 1440 QKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD 1499
              K    ++K   K  + P        + ++    T    DI I  +ICLN+VTM +E  
Sbjct: 1417 --KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHY 1474

Query: 1500 DQGKYMTLVLSRINLVFIVLFTGEFVLKLVSL-RHYYFTIGWNIFDFVVVILSIVGMFL- 1557
            +Q   +   L   N +F  +F  E VLKLV+     +F   WN  D  +V+LS++G+ L 
Sbjct: 1475 NQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLE 1534

Query: 1558 -AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLV 1616
              E+     ++PT+ R++R+ RI R+L+L+K A G+R LL  ++ +LP + N+GLL  L+
Sbjct: 1535 EIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLL 1594

Query: 1617 MFIYAIFGMSNFAYV-----KKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILN 1671
             FIYA  G+  F  +         G+     FE FG + + LFQ++T   W+G++   L 
Sbjct: 1595 FFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLR 1654

Query: 1672 SAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEE 1731
                DC  D     SS++       V   +FVS+++ +  V++N+ +AV++++   + +E
Sbjct: 1655 ----DCTHDERSCLSSLQ------FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKE 1704

Query: 1732 SAEPLSEDDFEMFYEVWEKFDP 1753
            + E  +E D E+  E+     P
Sbjct: 1705 AQED-AEMDAELELEMAHGLGP 1725



 Score =  150 bits (380), Expect = 9e-36
 Identities = 85/283 (30%), Positives = 161/283 (56%), Gaps = 10/283 (3%)

Query: 690 IWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLV 749
           +W C D W + +  +  IV   + +  I + I++NT+ M +EH+   E+ +++L + N+V
Sbjct: 584 VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVV 643

Query: 750 FTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRV 809
           FT +F  EM+LK+ A   + Y +  +NIFD IIV +S+ E+      GLSVLR+FRLLRV
Sbjct: 644 FTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRV 703

Query: 810 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDD 869
            KL +  P L   + ++  ++  +    ++L + +FIF+++GM +FG  +     + +  
Sbjct: 704 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFS---LRTDTG 760

Query: 870 CTLP-RWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVL 927
            T+P R + +    + + VF++L  E W   +++ M  +      + F+ +M  GN V+ 
Sbjct: 761 DTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSPWASLYFVALMTFGNYVLF 819

Query: 928 NLFLALLLSSFSSD---NLAATDDDNEMNNLQIAVGRMQKGID 967
           NL +A+L+  F ++   N + +D+D   +N++    ++Q+G+D
Sbjct: 820 NLLVAILVEGFQAEGDANRSYSDEDQSSSNIE-EFDKLQEGLD 861



 Score =  130 bits (327), Expect = 1e-29
 Identities = 107/411 (26%), Positives = 186/411 (45%), Gaps = 53/411 (12%)

Query: 70  PEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHSL 129
           P  + EPL+  DP+  +                 A  A + L      R   IK++ +  
Sbjct: 35  PPGLEEPLDGADPHVPHPDL--------------APIAFFCLRQTTSPRNWCIKMVCNPW 80

Query: 130 FSMLIMCTILTNCVFMTLSNP-------PDWTKNVEYTFTGIYTF---ESLIKILARGFC 179
           F  + M  IL NCV + +  P        D  K ++     I+ F   E ++K++A G  
Sbjct: 81  FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140

Query: 180 LEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNV--SALRTFRVLRALKTISVIPGLKTIV 237
            +   +L D WN LDF +++   V   +DL N+  SA+RT RVLR LK I+ +P ++ +V
Sbjct: 141 GKK-CYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILV 199

Query: 238 GALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC-----------LQWPPSDSA 286
             L+ ++  L +V++L  F   +F +IG+QL+ G LRN+C           +  PP    
Sbjct: 200 NLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQP 259

Query: 287 FETNTTSYFNGTMDSNGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDA 343
            E +   +       NG      +     +     +  D  +    G++D  L  +G   
Sbjct: 260 EEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQD--LNASGLCV 317

Query: 344 GQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIF 403
                  +C     NP+ G  +FD   +A++ +F+++T + W  +    + A      I+
Sbjct: 318 NWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIY 377

Query: 404 FVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKK 454
           F+L+I +GSF+++NL L V+A  +          +E K+ E + MLEQ ++
Sbjct: 378 FILLIIVGSFFMINLCLVVIATQF----------SETKQREHRLMLEQRQR 418



 Score =  109 bits (273), Expect = 2e-23
 Identities = 76/271 (28%), Positives = 133/271 (49%), Gaps = 31/271 (11%)

Query: 703  LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 762
            L++ +    ++D+ IT  I LN + M++EHY       + L   N +FT +F  E VLK+
Sbjct: 1444 LIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKL 1503

Query: 763  IAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVE----------GLSVLRSFRLLRVFKL 812
            +A     +F++ WN  D  IV LS+M + L  +E           + ++R  R+ RV KL
Sbjct: 1504 VAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKL 1563

Query: 813  AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTL 872
             K    +  L+  +  ++  +GNL L+  ++ FI+A +G++LFGK     VC   + C  
Sbjct: 1564 LKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGK----LVCNDENPCEG 1619

Query: 873  PRWH--MNDFFHSFLIVFRVLCGE-W----IETMWDCMEVAGQTMCL--------IVFML 917
               H    +F  +FL +F+V  G+ W     +T+ DC     +  CL        + F+ 
Sbjct: 1620 MSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTH--DERSCLSSLQFVSPLYFVS 1677

Query: 918  VMVIGNLVVLNLFLALLLSSFSSDNLAATDD 948
             ++    V++N+ +A+L+      N  A +D
Sbjct: 1678 FVLTAQFVLINVVVAVLMKHLDDSNKEAQED 1708



 Score =  107 bits (266), Expect = 1e-22
 Identities = 75/291 (25%), Positives = 135/291 (46%), Gaps = 38/291 (13%)

Query: 1462 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD--DQGKYMTLVLSRINLVFIVL 1519
            P N+F+ +    +  ++FD  ++  I LN +T+ +E    + G    + L+  N +F  +
Sbjct: 1120 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAI 1179

Query: 1520 FTGEFVLKLVSLRHY-----YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVI 1574
            F GE  LK+VSL  Y     Y    WN+ D  +V +SI+ + ++           + RV+
Sbjct: 1180 FVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVL 1239

Query: 1575 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF------ 1628
            RL R  R LR+I  A G++ ++  L+ SL  + NI L+      I+ I G+  F      
Sbjct: 1240 RLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYH 1299

Query: 1629 --------------AYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAP 1674
                                  +   +NF+  G +++ LF + +  GW  ++   L++  
Sbjct: 1300 CLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVA 1359

Query: 1675 PDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1725
             D  P T H          NP + + +F+S+++I    V+NM++ V++ENF
Sbjct: 1360 VDQQPVTNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1399



 Score =  100 bits (250), Expect = 1e-20
 Identities = 81/330 (24%), Positives = 149/330 (45%), Gaps = 46/330 (13%)

Query: 1140 GKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFT 1199
            G +W   R     IV+  +F   I+  IL+++ ++  E  + EQ + +  +LE  + VFT
Sbjct: 588  GDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNILEICNVVFT 645

Query: 1200 YIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRA 1259
             +F LEM+LK  A+G   Y  N +   D +IV +S+  +V  A      G +  LRT R 
Sbjct: 646  SMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA-----DGGLSVLRTFRL 700

Query: 1260 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1319
            LR L+ +     +R  +  L+  + ++    ++ ++F  IFSI+G+++F  KF    ++ 
Sbjct: 701  LRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKF----SLR 756

Query: 1320 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1379
            T     + D                   + NFD++    + + Q+ T + W  ++Y  + 
Sbjct: 757  TDTGDTVPD-------------------RKNFDSLLWAIVTVFQILTQEDWNVVLYNGMA 797

Query: 1380 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ---KKKFGGQDIFM 1436
            S           + +  LYFV  + FG++   NL + ++++ F  +    + +  +D   
Sbjct: 798  S----------TSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSS 847

Query: 1437 T--EEQKKYYNAMKKLGSKKPQKPIPRPAN 1464
            +  EE  K    +   G  K   PIP   N
Sbjct: 848  SNIEEFDKLQEGLDSSGDPK-LCPIPMTPN 876



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 90/373 (24%), Positives = 161/373 (43%), Gaps = 75/373 (20%)

Query: 107  ALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVE-------- 158
            ++Y+ +P N  R +   I+ H LF  +++  I  NC+ + L  P     + E        
Sbjct: 1114 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1173

Query: 159  YTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDL--------- 209
            Y FT I+  E  +K+++ G    +  +LR  WN LD  ++ ++ +   V L         
Sbjct: 1174 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1233

Query: 210  GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
            G +  LR  R LR L+ IS  PGLK +V  LI S+K + +++++      +F ++G+QLF
Sbjct: 1234 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1293

Query: 270  MGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLD 329
             G   + CL         +T   +  +  M +N  +V+     +N+ D +G       + 
Sbjct: 1294 KGKFYH-CL-------GVDTRNITNRSDCMAANYRWVH---HKYNF-DNLGQALMSLFVL 1341

Query: 330  GQKDPL--LCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWEN 387
              KD    +  NG DA    +  +      NP           W  L             
Sbjct: 1342 ASKDGWVNIMYNGLDAVAVDQQPV---TNHNP-----------WMLL------------- 1374

Query: 388  LYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQ 447
                        Y I F+L++   SF+++N+ + VV   + +  Q   +EAE+     ++
Sbjct: 1375 ------------YFISFLLIV---SFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEK 1417

Query: 448  MLEQLKKQQEEAQ 460
             L +L+K++ +AQ
Sbjct: 1418 RLRRLEKKRRKAQ 1430



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 71/274 (25%), Positives = 128/274 (46%), Gaps = 39/274 (14%)

Query: 703  LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLTVGNLVFTGIFTAEMV 759
            L   I+     D  +   I LN + +A+E  P  E  S+    LTV N +FT IF  EM 
Sbjct: 1127 LCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVSNYIFTAIFVGEMT 1185

Query: 760  LKIIAMDPYY----YFQEGWNIFDGIIVSLSLMELGLSNVEG--------LSVLRSFRLL 807
            LK++++  Y+    Y +  WN+ DG +V +S++++ +S            L VLR  R L
Sbjct: 1186 LKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTL 1245

Query: 808  RVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV---- 863
            R  ++    P L ++++ + +S+  +GN+ L+      IF ++G+QLF   +  C+    
Sbjct: 1246 RPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDT 1305

Query: 864  --CKINDDCTLP--RW--HMNDF--FHSFLIVFRVLCGE--WIETMWDCMEVAG------ 907
                   DC     RW  H  +F      L+   VL  +  W+  M++ ++         
Sbjct: 1306 RNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPV 1365

Query: 908  ---QTMCLIVFMLVMVIGNLVVLNLFLALLLSSF 938
                   L+ F+  ++I +  VLN+F+ +++ +F
Sbjct: 1366 TNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1399



 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 58/170 (34%), Positives = 93/170 (54%), Gaps = 11/170 (6%)

Query: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQ---RKTIKTMLEYADKVFTYIFI 1203
            R  C  +V + WFE   + +ILL+   L       +        K +  + D +F + F 
Sbjct: 69   RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIF-FA 127

Query: 1204 LEMLLKWVA---YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1260
            +EM+LK VA   +G + Y  + W  LDF IV   +  +V  +L    +  + ++RT+R L
Sbjct: 128  MEMVLKMVALGIFGKKCYLGDTWNRLDFFIV---MAGMVEYSLDLQNIN-LSAIRTVRVL 183

Query: 1261 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1310
            RPL+A++R   MR++VN L+  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 184  RPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 72/283 (25%), Positives = 135/283 (47%), Gaps = 35/283 (12%)

Query: 1474 VTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRH 1533
            V  + F+  IM+ I +N V+M +E  +Q + +T +L   N+VF  +F  E +LKL +   
Sbjct: 602  VDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL 661

Query: 1534 Y-YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1592
            + Y    +NIFD ++VI+SI      E++ +   +     V+R  R+ R+L+L++    +
Sbjct: 662  FDYLRNPYNIFDSIIVIISI-----WEIVGQ---ADGGLSVLRTFRLLRVLKLVRFMPAL 713

Query: 1593 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKKEAG--IDDMFNFETFG 1647
            R  L  LM ++  +    +LL L +FI++I GM  F     ++ + G  + D  NF++  
Sbjct: 714  RRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLL 773

Query: 1648 NSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYII 1707
             +++ +FQI T   W+ +L   + S  P                         +FV+ + 
Sbjct: 774  WAIVTVFQILTQEDWNVVLYNGMASTSPWAS---------------------LYFVALMT 812

Query: 1708 ISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEK 1750
                V+ N+ +A+++E F    + +     ED      E ++K
Sbjct: 813  FGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDK 855



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 32/98 (32%), Positives = 60/98 (61%), Gaps = 13/98 (13%)

Query: 1349 VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSF 1408
            +NFDN+G  ++ + QV T +GW++IMY  +D+           + Y ++YF++ II GSF
Sbjct: 338  INFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSF 387

Query: 1409 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1446
            F +NL + VI   F++ K++   +   M E++++Y ++
Sbjct: 388  FMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 46/148 (31%), Positives = 83/148 (56%), Gaps = 13/148 (8%)

Query: 130 FSMLIMCTILTNCVFMTLSN---PPDWTKNVEY---TFTGIYTFESLIKILARGFCLEDF 183
           F+  IM  IL N V M + +   P + T  +E     FT ++  E ++K+ A G     F
Sbjct: 607 FNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL----F 662

Query: 184 TFLRDPWNWLDFSVIVMAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
            +LR+P+N  D S+IV+  + E V    G +S LRTFR+LR LK +  +P L+  +  L+
Sbjct: 663 DYLRNPYNIFD-SIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLM 721

Query: 242 QSVKKLSDVMILTVFCLSVFALIGLQLF 269
           +++  ++   +L +  + +F+++G+ +F
Sbjct: 722 KTMDNVATFCMLLMLFIFIFSILGMHIF 749



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 49/186 (26%), Positives = 96/186 (51%), Gaps = 19/186 (10%)

Query: 707 IVMDPFVDLAITICIVLNTLFMAMEHYP------MTEQFSSVLTVGNLVFTGIFTAEMVL 760
           +V +P+ +    + I+LN + + M + P      ++++   +    + +F   F  EMVL
Sbjct: 75  MVCNPWFECVSMLVILLNCVTLGM-YQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEMVL 132

Query: 761 KIIAMDPY---YYFQEGWNIFDGIIVSLSLME--LGLSNVEGLSVLRSFRLLRVFKLAKS 815
           K++A+  +    Y  + WN  D  IV   ++E  L L N+  LS +R+ R+LR  K    
Sbjct: 133 KMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-LSAIRTVRVLRPLKAINR 191

Query: 816 WPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-----GKSYKECVCKINDDC 870
            P++ +L+ ++ +++  LGN+ L+   + FIF ++G+QL+      + + E    I  D 
Sbjct: 192 VPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDV 251

Query: 871 TLPRWH 876
            LP ++
Sbjct: 252 ALPPYY 257



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 47/159 (29%), Positives = 74/159 (46%), Gaps = 15/159 (9%)

Query: 1479 FDISIMILICLNMVTM-MVETDDQGKYMT---LVLSRINLVFIVLFTGEFVLKLVSL--- 1531
            F+   M++I LN VT+ M +  D    ++    +L   +    + F  E VLK+V+L   
Sbjct: 81   FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140

Query: 1532 -RHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1590
             +  Y    WN  DF +V+  +V   L        +       IR  R+ R L+ I    
Sbjct: 141  GKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIRTVRVLRPLKAINRVP 193

Query: 1591 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1629
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 194  SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWA 232



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 20/93 (21%), Positives = 52/93 (55%), Gaps = 2/93 (2%)

Query: 365 SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVA 424
           +FD+  WA +++F+++TQ+ W  +    + +      ++FV ++  G++ L NL++A++ 
Sbjct: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827

Query: 425 MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQE 457
             ++ +  A    +++ ++     +E+  K QE
Sbjct: 828 EGFQAEGDANRSYSDEDQS--SSNIEEFDKLQE 858



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 26/95 (27%), Positives = 49/95 (51%), Gaps = 12/95 (12%)

Query: 363  YTSFDTFSWAFLSLFRLMTQDYWENLYQLTLR-----------AAGKTYMIFFVLVIFLG 411
            + +F+ F  AFL+LF++ T D W  + + TLR           +      ++FV  +   
Sbjct: 1623 HATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTA 1682

Query: 412  SFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQ 446
             F L+N+++AV+    ++ N+   E+AE  +AE +
Sbjct: 1683 QFVLINVVVAVLMKHLDDSNKEAQEDAEM-DAELE 1716



 Score = 35.8 bits (81), Expect = 0.42
 Identities = 17/59 (28%), Positives = 39/59 (66%), Gaps = 2/59 (3%)

Query: 882 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 939
           ++++++F+V+  E W+E M+  M+ A      I F+L++++G+  ++NL L ++ + FS
Sbjct: 345 YAWIVIFQVITLEGWVEIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 402


>gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I
            subunit isoform a [Homo sapiens]
          Length = 2223

 Score =  343 bits (881), Expect = 7e-94
 Identities = 212/622 (34%), Positives = 344/622 (55%), Gaps = 36/622 (5%)

Query: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1206
            R  C +I+ H  F+  ++  I L+   +A E   IE   T +  L  ++ +FT IF+ EM
Sbjct: 1160 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1219

Query: 1207 LLKWVA----YGFQTYFTNAWCWLDFLIVDVSLVSLV---ANALGYSELGAIKSLRTLRA 1259
             LK V+    +G Q Y  ++W  LD  +V VS++ +V   A+A G   LG ++ LR LR 
Sbjct: 1220 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1279

Query: 1260 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1319
            LRPLR +SR  G+++VV  L+ ++  I N++L+C  F++IF I+GV LF GKFYHC+ + 
Sbjct: 1280 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVD 1339

Query: 1320 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1379
            T N      + N SDC A     RW + K NFDN+G   ++L  +A+  GW++IMY  +D
Sbjct: 1340 TRN------ITNRSDCMA--ANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLD 1391

Query: 1380 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1439
            +  V  QPV   N +M LYF+ F++  SFF LN+F+GV+++NF++ ++    ++    EE
Sbjct: 1392 AVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE 1451

Query: 1440 QKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD 1499
              K    ++K   K  + P        + ++    T    DI I  +ICLN+VTM +E  
Sbjct: 1452 --KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHY 1509

Query: 1500 DQGKYMTLVLSRINLVFIVLFTGEFVLKLVSL-RHYYFTIGWNIFDFVVVILSIVGMFL- 1557
            +Q   +   L   N +F  +F  E VLKLV+     +F   WN  D  +V+LS++G+ L 
Sbjct: 1510 NQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLE 1569

Query: 1558 -AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLV 1616
              E+     ++PT+ R++R+ RI R+L+L+K A G+R LL  ++ +LP + N+GLL  L+
Sbjct: 1570 EIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLL 1629

Query: 1617 MFIYAIFGMSNFAYV-----KKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILN 1671
             FIYA  G+  F  +         G+     FE FG + + LFQ++T   W+G++   L 
Sbjct: 1630 FFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLR 1689

Query: 1672 SAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEE 1731
                DC  D     SS++       V   +FVS+++ +  V++N+ +AV++++   + +E
Sbjct: 1690 ----DCTHDERSCLSSLQ------FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKE 1739

Query: 1732 SAEPLSEDDFEMFYEVWEKFDP 1753
            + E  +E D E+  E+     P
Sbjct: 1740 AQED-AEMDAELELEMAHGLGP 1760



 Score =  252 bits (643), Expect = 3e-66
 Identities = 237/945 (25%), Positives = 419/945 (44%), Gaps = 130/945 (13%)

Query: 70  PEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHSL 129
           P  + EPL+  DP+  +                 A  A + L      R   IK++ +  
Sbjct: 35  PPGLEEPLDGADPHVPHPDL--------------APIAFFCLRQTTSPRNWCIKMVCNPW 80

Query: 130 FSMLIMCTILTNCVFMTLSNP-------PDWTKNVEYTFTGIYTF---ESLIKILARGFC 179
           F  + M  IL NCV + +  P        D  K ++     I+ F   E ++K++A G  
Sbjct: 81  FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140

Query: 180 LEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNV--SALRTFRVLRALKTISVIPGLKTIV 237
            +   +L D WN LDF +++   V   +DL N+  SA+RT RVLR LK I+ +P ++ +V
Sbjct: 141 GKK-CYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILV 199

Query: 238 GALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC-----------LQWPPSDSA 286
             L+ ++  L +V++L  F   +F +IG+QL+ G LRN+C           +  PP    
Sbjct: 200 NLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQP 259

Query: 287 FETNTTSYFNGTMDSNGTFVNVTMSTFNWKDY---IGDDSHFYVLDGQKDPLLCGNGSDA 343
            E +   +       NG      +     +     +  D  +    G++D  L  +G   
Sbjct: 260 EEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQD--LNASGLCV 317

Query: 344 GQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIF 403
                  +C     NP+ G  +FD   +A++ +F+++T + W  +    + A      I+
Sbjct: 318 NWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIY 377

Query: 404 FVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVA 463
           F+L+I +GSF+++NL L V+A  +          +E K+ E + MLEQ  +Q+  + +  
Sbjct: 378 FILLIIVGSFFMINLCLVVIATQF----------SETKQREHRLMLEQ--RQRYLSSSTV 425

Query: 464 AASAASRD-----FSGIG-----------GLGELLESSSEASKLSSKSAKEWRNRRKKRR 507
           A+ A   D     F  +            GL + L+S  +A    + +  +     K+ R
Sbjct: 426 ASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPHAKEPR 485

Query: 508 QREHLEGNNKGERDSFPKSESEDSVKRSSFLFSMDGNRLTSDKKFCSPHQSLLSIRGSLF 567
              H  G  KG+ D      S     ++    +  GN   S ++ C  H  L +   +L 
Sbjct: 486 ---HYHGKTKGQGDEGRHLGSRHC--QTLHGPASPGND-HSGRELCPQHSPLDATPHTLV 539

Query: 568 SPRRNSKTSIFSFRGRAKDVGSENDFADDEHSTFEDSESRRDSLFVPHRHGERRNSNGTT 627
            P   +  S               D A       ED   RR S       G+  + +G++
Sbjct: 540 QPIPATLAS---------------DPASCPCCQHEDG--RRPSGLGSTDSGQEGSGSGSS 582

Query: 628 TETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELEESRQKCPPCWYRFANV 687
              E                 D  G + +   AS      EE EE               
Sbjct: 583 AGGEDEA--------------DGDGARSSEDGASSELGKEEEEEEQADGA---------- 618

Query: 688 FLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGN 747
             +W C D W + +  +  IV   + +  I + I++NT+ M +EH+   E+ +++L + N
Sbjct: 619 --VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICN 676

Query: 748 LVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLL 807
           +VFT +F  EM+LK+ A   + Y +  +NIFD IIV +S+ E+      GLSVLR+FRLL
Sbjct: 677 VVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLL 736

Query: 808 RVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIN 867
           RV KL +  P L   + ++  ++  +    ++L + +FIF+++GM +FG  +     + +
Sbjct: 737 RVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFS---LRTD 793

Query: 868 DDCTLP-RWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLV 925
              T+P R + +    + + VF++L  E W   +++ M  +      + F+ +M  GN V
Sbjct: 794 TGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSPWASLYFVALMTFGNYV 852

Query: 926 VLNLFLALLLSSFSSD---NLAATDDDNEMNNLQIAVGRMQKGID 967
           + NL +A+L+  F ++   N + +D+D   +N++    ++Q+G+D
Sbjct: 853 LFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIE-EFDKLQEGLD 896



 Score =  109 bits (273), Expect = 2e-23
 Identities = 76/271 (28%), Positives = 133/271 (49%), Gaps = 31/271 (11%)

Query: 703  LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 762
            L++ +    ++D+ IT  I LN + M++EHY       + L   N +FT +F  E VLK+
Sbjct: 1479 LIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKL 1538

Query: 763  IAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVE----------GLSVLRSFRLLRVFKL 812
            +A     +F++ WN  D  IV LS+M + L  +E           + ++R  R+ RV KL
Sbjct: 1539 VAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKL 1598

Query: 813  AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTL 872
             K    +  L+  +  ++  +GNL L+  ++ FI+A +G++LFGK     VC   + C  
Sbjct: 1599 LKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGK----LVCNDENPCEG 1654

Query: 873  PRWH--MNDFFHSFLIVFRVLCGE-W----IETMWDCMEVAGQTMCL--------IVFML 917
               H    +F  +FL +F+V  G+ W     +T+ DC     +  CL        + F+ 
Sbjct: 1655 MSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTH--DERSCLSSLQFVSPLYFVS 1712

Query: 918  VMVIGNLVVLNLFLALLLSSFSSDNLAATDD 948
             ++    V++N+ +A+L+      N  A +D
Sbjct: 1713 FVLTAQFVLINVVVAVLMKHLDDSNKEAQED 1743



 Score =  107 bits (266), Expect = 1e-22
 Identities = 75/291 (25%), Positives = 135/291 (46%), Gaps = 38/291 (13%)

Query: 1462 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD--DQGKYMTLVLSRINLVFIVL 1519
            P N+F+ +    +  ++FD  ++  I LN +T+ +E    + G    + L+  N +F  +
Sbjct: 1155 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAI 1214

Query: 1520 FTGEFVLKLVSLRHY-----YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVI 1574
            F GE  LK+VSL  Y     Y    WN+ D  +V +SI+ + ++           + RV+
Sbjct: 1215 FVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVL 1274

Query: 1575 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF------ 1628
            RL R  R LR+I  A G++ ++  L+ SL  + NI L+      I+ I G+  F      
Sbjct: 1275 RLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYH 1334

Query: 1629 --------------AYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAP 1674
                                  +   +NF+  G +++ LF + +  GW  ++   L++  
Sbjct: 1335 CLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVA 1394

Query: 1675 PDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1725
             D  P T H          NP + + +F+S+++I    V+NM++ V++ENF
Sbjct: 1395 VDQQPVTNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1434



 Score =  100 bits (250), Expect = 1e-20
 Identities = 81/330 (24%), Positives = 149/330 (45%), Gaps = 46/330 (13%)

Query: 1140 GKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFT 1199
            G +W   R     IV+  +F   I+  IL+++ ++  E  + EQ + +  +LE  + VFT
Sbjct: 623  GDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNILEICNVVFT 680

Query: 1200 YIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRA 1259
             +F LEM+LK  A+G   Y  N +   D +IV +S+  +V  A      G +  LRT R 
Sbjct: 681  SMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA-----DGGLSVLRTFRL 735

Query: 1260 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1319
            LR L+ +     +R  +  L+  + ++    ++ ++F  IFSI+G+++F  KF    ++ 
Sbjct: 736  LRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKF----SLR 791

Query: 1320 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1379
            T     + D                   + NFD++    + + Q+ T + W  ++Y  + 
Sbjct: 792  TDTGDTVPD-------------------RKNFDSLLWAIVTVFQILTQEDWNVVLYNGMA 832

Query: 1380 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ---KKKFGGQDIFM 1436
            S           + +  LYFV  + FG++   NL + ++++ F  +    + +  +D   
Sbjct: 833  S----------TSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSS 882

Query: 1437 T--EEQKKYYNAMKKLGSKKPQKPIPRPAN 1464
            +  EE  K    +   G  K   PIP   N
Sbjct: 883  SNIEEFDKLQEGLDSSGDPK-LCPIPMTPN 911



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 90/373 (24%), Positives = 161/373 (43%), Gaps = 75/373 (20%)

Query: 107  ALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVE-------- 158
            ++Y+ +P N  R +   I+ H LF  +++  I  NC+ + L  P     + E        
Sbjct: 1149 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1208

Query: 159  YTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDL--------- 209
            Y FT I+  E  +K+++ G    +  +LR  WN LD  ++ ++ +   V L         
Sbjct: 1209 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1268

Query: 210  GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
            G +  LR  R LR L+ IS  PGLK +V  LI S+K + +++++      +F ++G+QLF
Sbjct: 1269 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1328

Query: 270  MGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLD 329
             G   + CL         +T   +  +  M +N  +V+     +N+ D +G       + 
Sbjct: 1329 KGKFYH-CL-------GVDTRNITNRSDCMAANYRWVH---HKYNF-DNLGQALMSLFVL 1376

Query: 330  GQKDPL--LCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWEN 387
              KD    +  NG DA    +  +      NP           W  L             
Sbjct: 1377 ASKDGWVNIMYNGLDAVAVDQQPV---TNHNP-----------WMLL------------- 1409

Query: 388  LYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQ 447
                        Y I F+L++   SF+++N+ + VV   + +  Q   +EAE+     ++
Sbjct: 1410 ------------YFISFLLIV---SFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEK 1452

Query: 448  MLEQLKKQQEEAQ 460
             L +L+K++ +AQ
Sbjct: 1453 RLRRLEKKRRKAQ 1465



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 71/274 (25%), Positives = 128/274 (46%), Gaps = 39/274 (14%)

Query: 703  LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLTVGNLVFTGIFTAEMV 759
            L   I+     D  +   I LN + +A+E  P  E  S+    LTV N +FT IF  EM 
Sbjct: 1162 LCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVSNYIFTAIFVGEMT 1220

Query: 760  LKIIAMDPYY----YFQEGWNIFDGIIVSLSLMELGLSNVEG--------LSVLRSFRLL 807
            LK++++  Y+    Y +  WN+ DG +V +S++++ +S            L VLR  R L
Sbjct: 1221 LKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTL 1280

Query: 808  RVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV---- 863
            R  ++    P L ++++ + +S+  +GN+ L+      IF ++G+QLF   +  C+    
Sbjct: 1281 RPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDT 1340

Query: 864  --CKINDDCTLP--RW--HMNDF--FHSFLIVFRVLCGE--WIETMWDCMEVAG------ 907
                   DC     RW  H  +F      L+   VL  +  W+  M++ ++         
Sbjct: 1341 RNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPV 1400

Query: 908  ---QTMCLIVFMLVMVIGNLVVLNLFLALLLSSF 938
                   L+ F+  ++I +  VLN+F+ +++ +F
Sbjct: 1401 TNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1434



 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 58/170 (34%), Positives = 93/170 (54%), Gaps = 11/170 (6%)

Query: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQ---RKTIKTMLEYADKVFTYIFI 1203
            R  C  +V + WFE   + +ILL+   L       +        K +  + D +F + F 
Sbjct: 69   RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIF-FA 127

Query: 1204 LEMLLKWVA---YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1260
            +EM+LK VA   +G + Y  + W  LDF IV   +  +V  +L    +  + ++RT+R L
Sbjct: 128  MEMVLKMVALGIFGKKCYLGDTWNRLDFFIV---MAGMVEYSLDLQNIN-LSAIRTVRVL 183

Query: 1261 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1310
            RPL+A++R   MR++VN L+  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 184  RPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 72/283 (25%), Positives = 135/283 (47%), Gaps = 35/283 (12%)

Query: 1474 VTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRH 1533
            V  + F+  IM+ I +N V+M +E  +Q + +T +L   N+VF  +F  E +LKL +   
Sbjct: 637  VDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL 696

Query: 1534 Y-YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1592
            + Y    +NIFD ++VI+SI      E++ +   +     V+R  R+ R+L+L++    +
Sbjct: 697  FDYLRNPYNIFDSIIVIISI-----WEIVGQ---ADGGLSVLRTFRLLRVLKLVRFMPAL 748

Query: 1593 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKKEAG--IDDMFNFETFG 1647
            R  L  LM ++  +    +LL L +FI++I GM  F     ++ + G  + D  NF++  
Sbjct: 749  RRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLL 808

Query: 1648 NSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYII 1707
             +++ +FQI T   W+ +L   + S  P                         +FV+ + 
Sbjct: 809  WAIVTVFQILTQEDWNVVLYNGMASTSPWAS---------------------LYFVALMT 847

Query: 1708 ISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEK 1750
                V+ N+ +A+++E F    + +     ED      E ++K
Sbjct: 848  FGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDK 890



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 32/98 (32%), Positives = 60/98 (61%), Gaps = 13/98 (13%)

Query: 1349 VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSF 1408
            +NFDN+G  ++ + QV T +GW++IMY  +D+           + Y ++YF++ II GSF
Sbjct: 338  INFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSF 387

Query: 1409 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1446
            F +NL + VI   F++ K++   +   M E++++Y ++
Sbjct: 388  FMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 47/159 (29%), Positives = 74/159 (46%), Gaps = 15/159 (9%)

Query: 1479 FDISIMILICLNMVTM-MVETDDQGKYMT---LVLSRINLVFIVLFTGEFVLKLVSL--- 1531
            F+   M++I LN VT+ M +  D    ++    +L   +    + F  E VLK+V+L   
Sbjct: 81   FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140

Query: 1532 -RHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1590
             +  Y    WN  DF +V+  +V   L        +       IR  R+ R L+ I    
Sbjct: 141  GKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIRTVRVLRPLKAINRVP 193

Query: 1591 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1629
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 194  SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWA 232



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 26/95 (27%), Positives = 49/95 (51%), Gaps = 12/95 (12%)

Query: 363  YTSFDTFSWAFLSLFRLMTQDYWENLYQLTLR-----------AAGKTYMIFFVLVIFLG 411
            + +F+ F  AFL+LF++ T D W  + + TLR           +      ++FV  +   
Sbjct: 1658 HATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTA 1717

Query: 412  SFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQ 446
             F L+N+++AV+    ++ N+   E+AE  +AE +
Sbjct: 1718 QFVLINVVVAVLMKHLDDSNKEAQEDAEM-DAELE 1751


>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform b [Homo sapiens]
          Length = 2347

 Score =  338 bits (866), Expect = 4e-92
 Identities = 206/651 (31%), Positives = 359/651 (55%), Gaps = 41/651 (6%)

Query: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1206
            R +C  ++ H  F+  ++  I L+   +A E   I+   T +  L  ++ +FT IF+ EM
Sbjct: 1284 RVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEM 1343

Query: 1207 LLKWVAYGF----QTYFTNAWCWLDFLIVDVSLVSLV---ANALGYSELGAIKSLRTLRA 1259
            ++K VA G       Y  ++W  LD L+V VSLV +V   A+A G   LG ++ LR LR 
Sbjct: 1344 MVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRT 1403

Query: 1260 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1319
            LRPLR +SR  G+++VV  L+ ++  I N++L+C  F++IF I+GV LF GKFY+C    
Sbjct: 1404 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPD 1463

Query: 1320 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1379
            T N      ++  + C+A     RW   K NFDN+G   ++L  +++  GW++IMY  +D
Sbjct: 1464 TRN------ISTKAQCRA--AHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLD 1515

Query: 1380 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1439
            +  V  QPV   N +M LYF+ F++  SFF LN+F+GV+++NF++ ++    ++    EE
Sbjct: 1516 AVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE 1575

Query: 1440 QKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD 1499
              K    +++   K  ++P     +  +  +    T    D+ I  +IC+N++TM +E  
Sbjct: 1576 --KRLRRLERRRRKAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHY 1633

Query: 1500 DQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLR-HYYFTIGWNIFDFVVVILSIVGMFL- 1557
            +Q K +   L   N VF ++F  E  LKLV+     +F   WN  D  +V+LS++G+ L 
Sbjct: 1634 NQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLE 1693

Query: 1558 -AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLV 1616
              EM     ++PT+ R++R+ RI R+L+L+K A G+R LL  ++ +LP + N+GLL  L+
Sbjct: 1694 EIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLL 1753

Query: 1617 MFIYAIFGMSNFAYVKKE-----AGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILN 1671
             FIYA  G+  F  ++        G+     F  FG + + LF+++T   W+G++   L 
Sbjct: 1754 FFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLR 1813

Query: 1672 SAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEE 1731
                +C  +  H  S +      P++   +FV++++++  V+VN+ +AV++++   + +E
Sbjct: 1814 ----ECSREDKHCLSYL------PALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKE 1863

Query: 1732 SAEPLSEDDFEMFYEVWEKFDPDATQFIEFSK---LSDFAAALDPPLLIAK 1779
            + E  +E D E+  E+ +   P + + ++  +     +   A D P L+A+
Sbjct: 1864 ARED-AELDAEIELEMAQ--GPGSARRVDADRPPLPQESPGARDAPNLVAR 1911



 Score =  141 bits (355), Expect = 7e-33
 Identities = 83/258 (32%), Positives = 145/258 (56%), Gaps = 9/258 (3%)

Query: 697  WLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTA 756
            W+     +  IV   +    I + I++NTL M +E++   E+ ++ L + N+VFT +F  
Sbjct: 779  WVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFAL 838

Query: 757  EMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSW 816
            EM+LK++A  P  Y +  +NIFDGIIV +S+ E+      GLSVLR+FRLLRV KL +  
Sbjct: 839  EMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFL 898

Query: 817  PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP-RW 875
            P L   + ++  ++  +     +L + +FIF+++GM LFG  +     K +   T+P R 
Sbjct: 899  PALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFS---LKTDTGDTVPDRK 955

Query: 876  HMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALL 934
            + +    + + VF++L  E W   +++ M  +  +   + F+ +M  GN V+ NL +A+L
Sbjct: 956  NFDSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSSWAALYFVALMTFGNYVLFNLLVAIL 1014

Query: 935  LSSFSSD---NLAATDDD 949
            +  F ++   N + TD+D
Sbjct: 1015 VEGFQAEGDANRSDTDED 1032



 Score =  132 bits (332), Expect = 3e-30
 Identities = 109/470 (23%), Positives = 204/470 (43%), Gaps = 95/470 (20%)

Query: 104 ATSALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTK------NV 157
           A +  + L      R   ++++ +  F  + M  I+ NCV + +  P +  +      N+
Sbjct: 76  AATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNI 135

Query: 158 EYTFTGI----YTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVS 213
              F       +  E +IK++A G   +   +L D WN LDF ++V   +   +D  NVS
Sbjct: 136 LEAFDAFIFAFFAVEMVIKMVALGLFGQK-CYLGDTWNRLDFFIVVAGMMEYSLDGHNVS 194

Query: 214 --ALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
             A+RT RVLR L+ I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G
Sbjct: 195 LSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254

Query: 272 NLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQ 331
            LRN+C      DSAF  N          +N TF+                 ++   +G+
Sbjct: 255 LLRNRCF----LDSAFVRN----------NNLTFLR---------------PYYQTEEGE 285

Query: 332 KDPLLCGNGSDAGQ---------------CPEGY-------------------------- 350
           ++P +C +  D G                C  G+                          
Sbjct: 286 ENPFICSSRRDNGMQKCSHIPGRRELRMPCTLGWEAYTQPQAEGVGAARNACINWNQYYN 345

Query: 351 ICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFL 410
           +C     NP+ G  +FD   +A++++F+++T + W ++    + A      I+F+L+I +
Sbjct: 346 VCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIV 405

Query: 411 GSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASR 470
           GSF+++NL L V+A  +          +E K+ E Q M EQ  +       +A+ S    
Sbjct: 406 GSFFMINLCLVVIATQF----------SETKQRESQLMREQRARHLSNDSTLASFSEPGS 455

Query: 471 DFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGER 520
            +  +  L  +     +  + S +    W++R +K+     ++G   G R
Sbjct: 456 CYEEL--LKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQGPGHR 503



 Score =  115 bits (287), Expect = 5e-25
 Identities = 131/634 (20%), Positives = 260/634 (41%), Gaps = 91/634 (14%)

Query: 365  SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVA 424
            +FD+  WA +++F+++TQ+ W  +    + +      ++FV ++  G++ L NL++A++ 
Sbjct: 956  NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILV 1015

Query: 425  MAYEEQNQATLEEAEQKEAE--FQQMLEQLKK-QQEEAQAVAAASAASRDFSGIGGLGEL 481
              ++ +  A   + ++ +    F++   +L++ Q  E +  + A   +    G G L   
Sbjct: 1016 EGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPP 1075

Query: 482  LESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFSM 541
            L   + A+ + +                            S P  ++  S+  S    S 
Sbjct: 1076 LIMCTAATPMPTPK--------------------------SSPFLDAAPSLPDSRRGSSS 1109

Query: 542  DGNRLTSDKKFCSPHQSLLSIRGSLFSPRR--NSKTSIFSFRGRAKDVGSENDFADDEHS 599
             G+    D+K   P  SL S   + + P    +S+ S +S  GRA  +       + E  
Sbjct: 1110 SGDPPLGDQK---PPASLRSSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESL 1166

Query: 600  TFEDSESRRDSLFVPHRHGERRNSNGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVS- 658
               + +   D      R      +        +  R L    +      D  G+  A+  
Sbjct: 1167 LSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALPS 1226

Query: 659  -----IASILTNTMEELEESRQKC-----------PPCWYRFANVFLIWDCCDAWLKVKH 702
                 I S   +  E  ++S   C            P W R    + ++       + + 
Sbjct: 1227 DFFLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALY-LFSPQNRFRV 1285

Query: 703  LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLTVGNLVFTGIFTAEMV 759
                ++     D  + + I LN + +A+E  P  +  S+    L+V N +FT IF AEM+
Sbjct: 1286 SCQKVITHKMFDHVVLVFIFLNCVTIALER-PDIDPGSTERVFLSVSNYIFTAIFVAEMM 1344

Query: 760  LKIIAMD----PYYYFQEGWNIFDGIIVSLSLMEL--------GLSNVEGLSVLRSFRLL 807
            +K++A+      + Y Q  WN+ DG++V +SL+++        G   +  L VLR  R L
Sbjct: 1345 VKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTL 1404

Query: 808  RVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSY------- 859
            R  ++    P L ++++ + +S+  +GN+ L+      IF ++G+QLF GK Y       
Sbjct: 1405 RPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDT 1464

Query: 860  ----KECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGE--WIETMWDCMEVAG------ 907
                 +  C+      + R +  D     L+   VL  +  W+  M+D ++  G      
Sbjct: 1465 RNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPV 1524

Query: 908  ---QTMCLIVFMLVMVIGNLVVLNLFLALLLSSF 938
                   L+ F+  ++I +  VLN+F+ +++ +F
Sbjct: 1525 QNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1558



 Score =  109 bits (272), Expect = 3e-23
 Identities = 75/260 (28%), Positives = 128/260 (49%), Gaps = 27/260 (10%)

Query: 712  FVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYF 771
            ++DL IT  I +N + M+MEHY   +     L   N VFT +F  E  LK++A     +F
Sbjct: 1612 YLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFF 1671

Query: 772  QEGWNIFDGIIVSLSLMELGLSNVEG----------LSVLRSFRLLRVFKLAKSWPTLNM 821
            ++ WN  D  IV LSLM + L  +E           + ++R  R+ RV KL K    +  
Sbjct: 1672 KDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRA 1731

Query: 822  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWH--MND 879
            L+  +  ++  +GNL L+  ++ FI+A +G++LFG+      C  ++ C     H   ++
Sbjct: 1732 LLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR----LECSEDNPCEGLSRHATFSN 1787

Query: 880  FFHSFLIVFRVLCGE-WIETMWDCMEVAGQ--TMCL--------IVFMLVMVIGNLVVLN 928
            F  +FL +FRV  G+ W   M D +    +    CL        + F+  +++   V++N
Sbjct: 1788 FGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVN 1847

Query: 929  LFLALLLSSFSSDNLAATDD 948
            + +A+L+      N  A +D
Sbjct: 1848 VVVAVLMKHLEESNKEARED 1867



 Score =  106 bits (265), Expect = 2e-22
 Identities = 76/291 (26%), Positives = 138/291 (47%), Gaps = 38/291 (13%)

Query: 1462 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD--DQGKYMTLVLSRINLVFIVL 1519
            P N+F+      +T ++FD  +++ I LN VT+ +E    D G    + LS  N +F  +
Sbjct: 1279 PQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAI 1338

Query: 1520 FTGEFVLKLVSL-----RHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVI 1574
            F  E ++K+V+L      H Y    WN+ D ++V++S+V + +A           + RV+
Sbjct: 1339 FVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVL 1398

Query: 1575 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF------ 1628
            RL R  R LR+I  A G++ ++  L+ SL  + NI L+      I+ I G+  F      
Sbjct: 1399 RLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYY 1458

Query: 1629 --------------AYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAP 1674
                                  +   +NF+  G +++ LF +++  GW  ++   L++  
Sbjct: 1459 CEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVG 1518

Query: 1675 PDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1725
             D  P   H          NP + + +F+S+++I    V+NM++ V++ENF
Sbjct: 1519 VDQQPVQNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1558



 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 79/280 (28%), Positives = 128/280 (45%), Gaps = 28/280 (10%)

Query: 9    PGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFIYGDI 68
            PGP +  L   ESL   + R     A  P K +D D +    P SD        F+  D 
Sbjct: 1186 PGPRATPLRRAESL---DPRPLRPAALPPTKCRDRDGQVVALP-SDF-------FLRIDS 1234

Query: 69   PPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHS 128
              E  +E  +D +     +   ++        R     ALY+ +P N  R    K++ H 
Sbjct: 1235 HREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHK 1294

Query: 129  LFSMLIMCTILTNCVFMTLSNP---PDWTKNV-----EYTFTGIYTFESLIKILARGFCL 180
            +F  +++  I  NCV + L  P   P  T+ V      Y FT I+  E ++K++A G   
Sbjct: 1295 MFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLS 1354

Query: 181  EDFTFLRDPWNWLDFSVIVMAYVTEFVD---------LGNVSALRTFRVLRALKTISVIP 231
             +  +L+  WN LD  +++++ V   V          LG +  LR  R LR L+ IS  P
Sbjct: 1355 GEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAP 1414

Query: 232  GLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
            GLK +V  LI S++ + +++++      +F ++G+QLF G
Sbjct: 1415 GLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKG 1454



 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 74/286 (25%), Positives = 133/286 (46%), Gaps = 40/286 (13%)

Query: 1140 GKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFT 1199
            G++W         IV+  +F   I+  IL+++ ++  E  Y EQ + +   LE ++ VFT
Sbjct: 776  GRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVE--YHEQPEELTNALEISNIVFT 833

Query: 1200 YIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRA 1259
             +F LEMLLK +A G   Y  N +   D +IV +S+  +V  A      G +  LRT R 
Sbjct: 834  SMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQA-----DGGLSVLRTFRL 888

Query: 1260 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1319
            LR L+ +     +R  +  LV  + ++     + ++F  IFSI+G++LF  KF    ++ 
Sbjct: 889  LRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKF----SLK 944

Query: 1320 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1379
            T     + D                   + NFD++    + + Q+ T + W  ++Y  + 
Sbjct: 945  TDTGDTVPD-------------------RKNFDSLLWAIVTVFQILTQEDWNVVLYNGMA 985

Query: 1380 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1425
            S           + +  LYFV  + FG++   NL + ++++ F  +
Sbjct: 986  S----------TSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021



 Score = 91.3 bits (225), Expect = 8e-18
 Identities = 61/174 (35%), Positives = 93/174 (53%), Gaps = 19/174 (10%)

Query: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRKTIKTMLEYADKVFTYIF 1202
            R  C  +V + WFE   + +I+L+   L      ED+     +    +LE  D      F
Sbjct: 90   RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERC--NILEAFDAFIFAFF 147

Query: 1203 ILEMLLKWVA---YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELG---AIKSLRT 1256
             +EM++K VA   +G + Y  + W  LDF IV       VA  + YS  G   ++ ++RT
Sbjct: 148  AVEMVIKMVALGLFGQKCYLGDTWNRLDFFIV-------VAGMMEYSLDGHNVSLSAIRT 200

Query: 1257 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1310
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 201  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 73/290 (25%), Positives = 131/290 (45%), Gaps = 41/290 (14%)

Query: 1466 FQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFV 1525
            F G +   V  + F   IM+ I +N ++M VE  +Q + +T  L   N+VF  +F  E +
Sbjct: 782  FSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEML 841

Query: 1526 LKLVSLRHY-YFTIGWNIFDFVVVILS---IVGMFLAEMIEKYFVSPTLFRVIRLARIGR 1581
            LKL++     Y    +NIFD ++V++S   IVG            +     V+R  R+ R
Sbjct: 842  LKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQ-----------ADGGLSVLRTFRLLR 890

Query: 1582 ILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKKEAG-- 1636
            +L+L++    +R  L  L+ ++  +     LL L +FI++I GM  F     +K + G  
Sbjct: 891  VLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDT 950

Query: 1637 IDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPS 1696
            + D  NF++   +++ +FQI T   W+ +L                       G     S
Sbjct: 951  VPDRKNFDSLLWAIVTVFQILTQEDWNVVL---------------------YNGMASTSS 989

Query: 1697 VGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE 1746
                +FV+ +     V+ N+ +A+++E F    + +     ED   + +E
Sbjct: 990  WAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 41/132 (31%), Positives = 70/132 (53%), Gaps = 13/132 (9%)

Query: 1346 NVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIF 1405
            N  +NFDN+G  ++A+ QV T +GW+DIMY  +D+           + Y ++YF++ II 
Sbjct: 356  NGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDA----------HSFYNFIYFILLIIV 405

Query: 1406 GSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANK 1465
            GSFF +NL + VI   F++ K++   +   M E++ ++ +    L S            K
Sbjct: 406  GSFFMINLCLVVIATQFSETKQR---ESQLMREQRARHLSNDSTLASFSEPGSCYEELLK 462

Query: 1466 FQGMVFDFVTRQ 1477
            + G +F  V R+
Sbjct: 463  YVGHIFRKVKRR 474



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 48/155 (30%), Positives = 84/155 (54%), Gaps = 13/155 (8%)

Query: 123 KILVHSLFSMLIMCTILTNCVFMTLS---NPPDWTKNVEYT---FTGIYTFESLIKILAR 176
           +I+    FS  IM  IL N + M +     P + T  +E +   FT ++  E L+K+LA 
Sbjct: 788 RIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLAC 847

Query: 177 GFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 234
           G       ++R+P+N  D  +IV+  V E V    G +S LRTFR+LR LK +  +P L+
Sbjct: 848 G----PLGYIRNPYNIFD-GIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALR 902

Query: 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
             +  L++++  ++    L +  + +F+++G+ LF
Sbjct: 903 RQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLF 937



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 42/157 (26%), Positives = 80/157 (50%), Gaps = 8/157 (5%)

Query: 707 IVMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 762
           +V +P+ +    + I+LN + + M    E      +  ++L   +      F  EMV+K+
Sbjct: 96  LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155

Query: 763 IAMDPY---YYFQEGWNIFDGIIVSLSLMELGLSNVE-GLSVLRSFRLLRVFKLAKSWPT 818
           +A+  +    Y  + WN  D  IV   +ME  L      LS +R+ R+LR  +     P+
Sbjct: 156 VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPS 215

Query: 819 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 855
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 216 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 44/198 (22%), Positives = 95/198 (47%), Gaps = 24/198 (12%)

Query: 115  NPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLS--NPP----DWTKNVEYTFTGIYTFE 168
            +P R+    +       + I   I  N + M++   N P    +  K   Y FT ++ FE
Sbjct: 1598 SPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFE 1657

Query: 169  SLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSA-----------LRT 217
            + +K++A GF      F +D WN LD ++++++ +   ++   +SA           +R 
Sbjct: 1658 AALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRV 1713

Query: 218  FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC 277
             R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    ++A +G++LF    R +C
Sbjct: 1714 LRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFG---RLEC 1770

Query: 278  LQWPPSDSAFETNTTSYF 295
             +  P +      T S F
Sbjct: 1771 SEDNPCEGLSRHATFSNF 1788



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 48/159 (30%), Positives = 75/159 (47%), Gaps = 15/159 (9%)

Query: 1479 FDISIMILICLNMVTMMV----ETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHY 1534
            F+   M++I LN VT+ +    E  + G     +L   +      F  E V+K+V+L  +
Sbjct: 102  FEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLF 161

Query: 1535 ----YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1590
                Y    WN  DF +V+  ++   L    + + VS      IR  R+ R LR I    
Sbjct: 162  GQKCYLGDTWNRLDFFIVVAGMMEYSL----DGHNVS---LSAIRTVRVLRPLRAINRVP 214

Query: 1591 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1629
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 215  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253



 Score = 55.5 bits (132), Expect = 5e-07
 Identities = 39/141 (27%), Positives = 65/141 (46%), Gaps = 19/141 (13%)

Query: 345  QCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGK------ 398
            +C E   C    R     + +F  F  AFL+LFR+ T D W  + + TLR   +      
Sbjct: 1769 ECSEDNPCEGLSR-----HATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCL 1823

Query: 399  TYM-----IFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAE---QKEAEFQQMLE 450
            +Y+     ++FV  + +  F LVN+++AV+    EE N+   E+AE   + E E  Q   
Sbjct: 1824 SYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEMAQGPG 1883

Query: 451  QLKKQQEEAQAVAAASAASRD 471
              ++   +   +   S  +RD
Sbjct: 1884 SARRVDADRPPLPQESPGARD 1904



 Score = 33.1 bits (74), Expect = 2.7
 Identities = 16/59 (27%), Positives = 38/59 (64%), Gaps = 2/59 (3%)

Query: 882 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 939
           ++++ +F+V+  E W++ M+  M+ A      I F+L++++G+  ++NL L ++ + FS
Sbjct: 366 YAWIAIFQVITLEGWVDIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 423



 Score = 32.7 bits (73), Expect = 3.6
 Identities = 18/97 (18%), Positives = 40/97 (41%), Gaps = 21/97 (21%)

Query: 1642 NFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFF 1701
            NF+  G + I +FQ+ T  GW  ++  ++++                     +      +
Sbjct: 360  NFDNIGYAWIAIFQVITLEGWVDIMYYVMDA---------------------HSFYNFIY 398

Query: 1702 FVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1738
            F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 399  FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 435


>gi|192807298 calcium channel, voltage-dependent, L type, alpha 1D
            subunit isoform c [Homo sapiens]
          Length = 2137

 Score =  333 bits (855), Expect = 7e-91
 Identities = 243/823 (29%), Positives = 417/823 (50%), Gaps = 83/823 (10%)

Query: 1050 LTVTVPIAVGE-SDFENLNTEEFSSESELEE--------------SKEKLNATSSSEGS- 1093
            L V + IAV   +D E+LNT +     E E               +K ++N  ++S+   
Sbjct: 744  LNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKV 803

Query: 1094 TVDVVLPRE-------------GEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKG 1140
            T+D     +             GE+ E E E++ +  A      I +    +      +G
Sbjct: 804  TIDDYREEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEG 863

Query: 1141 KIWWNLRKT------CYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYA 1194
              ++ L KT      C+ ++ H+ F   I+  I+LSS ALA ED  I       T+L Y 
Sbjct: 864  SAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDP-IRSHSFRNTILGYF 922

Query: 1195 DKVFTYIFILEMLLKWVAYGF----QTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGA 1250
            D  FT IF +E+LLK   +G       +  N +  LD L+V VSLVS     +  S +  
Sbjct: 923  DYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSF---GIQSSAISV 979

Query: 1251 IKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1310
            +K LR LR LRPLRA++R +G++ VV  +  AI +I N+++V  +   +F+ +GV LF G
Sbjct: 980  VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKG 1039

Query: 1311 KFYHCVNMTTGN---------MFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLAL 1361
            KFY C +    N         ++   DV++      + ++  W+N   NFDNV +  +AL
Sbjct: 1040 KFYRCTDEAKSNPEECRGLFILYKDGDVDS-----PVVRERIWQNSDFNFDNVLSAMMAL 1094

Query: 1362 LQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDN 1421
              V+TF+GW  ++Y A+DS    + P+Y   + + ++F+I+II  +FF +N+F+G +I  
Sbjct: 1095 FTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVT 1154

Query: 1422 FNQQ-KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPR--PANKFQGMVFDFVTRQV 1478
            F +Q +K++   ++   + Q   Y A+K        +P+ R  P N +Q   +  V    
Sbjct: 1155 FQEQGEKEYKNCELDKNQRQCVEY-ALK-------ARPLRRYIPKNPYQYKFWYVVNSSP 1206

Query: 1479 FDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLR-HYYFT 1537
            F+  + +LI LN + + ++  +Q K     +  +N+VF  +FT E VLK+++ +   YF+
Sbjct: 1207 FEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFS 1266

Query: 1538 IGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLF 1597
              WN FD ++VI SI+ + L+E       +       RL R+ R+++L+   +GIRTLL+
Sbjct: 1267 DAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLW 1326

Query: 1598 ALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYV--KKEAGIDDMFNFETFGNSMICLFQ 1655
              + S  AL  + LL+ ++ FIYA+ GM  F  V  +    I+   NF+TF  +++ LF+
Sbjct: 1327 TFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFR 1386

Query: 1656 ITTSAGWDGLLAPILNSAPPDCDPDT-IHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVV 1714
              T   W  ++   L      CDP++  +PG      CG+ +  I +F+S+ ++   +++
Sbjct: 1387 CATGEAWQEIMLACLPGKL--CDPESDYNPGEEY--TCGS-NFAIVYFISFYMLCAFLII 1441

Query: 1715 NMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPP 1774
            N+++AVI++NF   T + +  L     + F  +W ++DP+A   I+   +      + PP
Sbjct: 1442 NLFVAVIMDNFDYLTRDWS-ILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPP 1500

Query: 1775 LLIAK--PNKV---QLIAMDLPMVSGDRIHCLDILFAFTKRVL 1812
            L   K  P++V   +L+AM++P+ S   +     LFA  +  L
Sbjct: 1501 LGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTAL 1543



 Score =  150 bits (378), Expect = 2e-35
 Identities = 121/457 (26%), Positives = 207/457 (45%), Gaps = 98/457 (21%)

Query: 107 ALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNP-PDWTKN--------V 157
           AL+ L+  NP+R+  I I+    F + I+  I  NCV + +  P P+   N        V
Sbjct: 105 ALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKV 164

Query: 158 EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAY-------VTEFVDLG 210
           EY F  I+T E+ +KI+A G  L    ++R+ WN LDF ++++         +T+  + G
Sbjct: 165 EYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGG 224

Query: 211 N----------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSV 260
           N          V ALR FRVLR L+ +S +P L+ ++ ++I+++  L  + +L +F + +
Sbjct: 225 NHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284

Query: 261 FALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIG 320
           +A+IGL+LF+G +   C                                   F   D + 
Sbjct: 285 YAIIGLELFIGKMHKTCF----------------------------------FADSDIVA 310

Query: 321 DDSHFYVLDGQKDPLLCGNGSDAGQC-PEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRL 379
           ++          DP  C    +  QC   G  C      PN G T+FD F++A L++F+ 
Sbjct: 311 EE----------DPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360

Query: 380 MTQDYWEN-LYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAY-EEQNQATLEE 437
           +T + W + LY +      +   ++FV ++  GSF+++NL+L V++  + +E+ +A    
Sbjct: 361 ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG 420

Query: 438 AEQKEAEFQQMLEQLK--------------KQQEEA-------QAVAAASAASRDFSGIG 476
             QK  E QQ+ E LK              + +EE         ++  +   S +   + 
Sbjct: 421 DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS 480

Query: 477 GLGELLESSSEASKLSSKS--AKEWR--NRRKKRRQR 509
           G GE         +  SKS  ++ WR  NR  +RR R
Sbjct: 481 GEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCR 517



 Score =  143 bits (360), Expect = 2e-33
 Identities = 101/327 (30%), Positives = 157/327 (48%), Gaps = 42/327 (12%)

Query: 1146 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYI----EQRKTIKTMLEYADKVFTYI 1201
            +R+ C SIVE   F+ FI+  I  +  ALA   IYI    +   +    LE  +  F  I
Sbjct: 115  IRRACISIVEWKPFDIFILLAIFANCVALA---IYIPFPEDDSNSTNHNLEKVEYAFLII 171

Query: 1202 FILEMLLKWVAYGF----QTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGA------- 1250
            F +E  LK +AYG       Y  N W  LDF+IV V L S++   L     G        
Sbjct: 172  FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231

Query: 1251 ----IKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVN 1306
                +K+LR  R LRPLR +S    ++VV+N+++ A+  ++++ L+ L   +I++I+G+ 
Sbjct: 232  GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 291

Query: 1307 LFAGKFYHCVNMTTGNMFDISD------VNNLSDCQALGKQAR--WKNVK---VNFDNVG 1355
            LF GK +        ++    D        N   C A G + R  W        NFDN  
Sbjct: 292  LFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFA 351

Query: 1356 AGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFI 1415
               L + Q  T +GW D++Y   D+   +L          ++YFV  +IFGSFF LNL +
Sbjct: 352  FAMLTVFQCITMEGWTDVLYWMNDAMGFELP---------WVYFVSLVIFGSFFVLNLVL 402

Query: 1416 GVIIDNFNQQKKKFGGQDIFMTEEQKK 1442
            GV+   F+++++K   +  F    +K+
Sbjct: 403  GVLSGEFSKEREKAKARGDFQKLREKQ 429



 Score =  131 bits (329), Expect = 7e-30
 Identities = 83/283 (29%), Positives = 143/283 (50%), Gaps = 42/283 (14%)

Query: 693  CCDAWLKVKHLVNLIVMDPF------------VDLAITICIVLNTLFMAMEHYPMTEQFS 740
            C +  LK + L   I  +P+             +  + + I+LNTL +AM+HY  ++ F+
Sbjct: 1175 CVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFN 1234

Query: 741  SVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVE---- 796
              + + N+VFTG+FT EMVLK+IA  P  YF + WN FD +IV  S++++ LS  +    
Sbjct: 1235 DAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEE 1294

Query: 797  ----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 852
                 ++  R FR++R+ KL      +  L+     S  AL  + L++A++ FI+AV+GM
Sbjct: 1295 SNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGM 1354

Query: 853  QLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCME------- 904
            Q+FGK       +IN +      +   F  + L++FR   GE W E M  C+        
Sbjct: 1355 QMFGKVAMRDNNQINRNN-----NFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPE 1409

Query: 905  ---------VAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSF 938
                       G    ++ F+   ++   +++NLF+A+++ +F
Sbjct: 1410 SDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1452



 Score =  127 bits (318), Expect = 1e-28
 Identities = 85/279 (30%), Positives = 149/279 (53%), Gaps = 25/279 (8%)

Query: 717 ITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWN 776
           + + + LNTL ++ EHY   +  + +  + N V   +FT EM++K+ ++    YF   +N
Sbjct: 529 VIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFN 588

Query: 777 IFD-----GIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVG 831
            FD     G I    L+EL + +  G+SV R  RLLR+FK+ + W +L+ L+  + NS+ 
Sbjct: 589 RFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMK 648

Query: 832 ALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVL 891
           ++ +L L+L + + IF+++GMQLFG  +        D+    R   ++F  + L VF++L
Sbjct: 649 SIASLLLLLFLFIIIFSLLGMQLFGGKFN------FDETQTKRSTFDNFPQALLTVFQIL 702

Query: 892 CGE-WIETMWDCM------EVAGQTMCLIVFMLVMVIGNLVVLNLFLALL---LSSFSSD 941
            GE W   M+D +        +G  +C I F+++ + GN ++LN+FLA+    L+   S 
Sbjct: 703 TGEDWNAVMYDGIMAYGGPSSSGMIVC-IYFIILFICGNYILLNVFLAIAVDNLADAESL 761

Query: 942 NLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQKA 980
           N A  ++  E    +IA    ++ ++  KN   E  Q A
Sbjct: 762 NTAQKEEAEEKERKKIA---RKESLENKKNNKPEVNQIA 797



 Score =  106 bits (264), Expect = 3e-22
 Identities = 108/473 (22%), Positives = 195/473 (41%), Gaps = 89/473 (18%)

Query: 20   ESLAAIEKRAAEEKAKKP---KKEQDNDDENKPKPNSDLEAGKNL-------------PF 63
            ESL   +K  AEEK +K    K+  +N   NKP+ N    +   +             P+
Sbjct: 759  ESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPY 818

Query: 64   IYGDIPPEMVSEPLEDLDPYYI---NKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKI 120
               D+P     E  E+ +P        +    +N  + I      SA +IL+  NP+R  
Sbjct: 819  PPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVG 878

Query: 121  AIKILVHSLFSMLIMCTILTNCVFMTLSNP---PDWTKNV----EYTFTGIYTFESLIKI 173
              K++ H +F+ LI+  I+ +   +   +P     +   +    +Y FT I+T E L+K+
Sbjct: 879  CHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKM 938

Query: 174  LARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSA---LRTFRVLRALKTISVI 230
               G  L    F R+ +N LD  V+ ++ V+  +    +S    LR  RVLR L+ I+  
Sbjct: 939  TTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRA 998

Query: 231  PGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETN 290
             GLK +V  +  +++ + ++MI+T     +FA IG+QLF G               F   
Sbjct: 999  KGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGK--------------FYRC 1044

Query: 291  TTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGY 350
            T    +   +  G F+        +KD                          G      
Sbjct: 1045 TDEAKSNPEECRGLFI-------LYKD--------------------------GDVDSPV 1071

Query: 351  ICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKT----------Y 400
            +  +  +N ++   +FD    A ++LF + T + W  L    + + G+            
Sbjct: 1072 VRERIWQNSDF---NFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEI 1128

Query: 401  MIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLK 453
             IFF++ I + +F+++N+ +  V + ++EQ +   +  E  + + Q +   LK
Sbjct: 1129 SIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALK 1181



 Score =  104 bits (259), Expect = 1e-21
 Identities = 89/394 (22%), Positives = 161/394 (40%), Gaps = 52/394 (13%)

Query: 1069 EEFSSESELEESKEKLNATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKF 1128
            E+   E+E E  +E    TS     T  V       + E               GC    
Sbjct: 446  EDIDPENEEEGGEEGKRNTSMPTSETESVNTENVSGEGENR-------------GCCGSL 492

Query: 1129 PFCQVSTEEGKGKIW--WNL--RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQR 1184
              CQ  ++    + W  WN   R+ C + V+   F   ++ ++ L++  ++ E  +  Q 
Sbjct: 493  --CQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSE--HYNQP 548

Query: 1185 KTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALG 1244
              +  + + A+KV   +F  EML+K  + G Q YF + +   D  +V   +   +   L 
Sbjct: 549  DWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELE 608

Query: 1245 YSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMG 1304
                  I   R +R LR  +    +  +  +V +L+ ++ SI ++LL+  +F +IFS++G
Sbjct: 609  IMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLG 668

Query: 1305 VNLFAGKFYHCVNMTTGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQV 1364
            + LF GKF                  N  + Q           +  FDN     L + Q+
Sbjct: 669  MQLFGGKF------------------NFDETQ---------TKRSTFDNFPQALLTVFQI 701

Query: 1365 ATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQ 1424
             T + W  +MY  +    +         + + +YF+I  I G++  LN+F+ + +DN   
Sbjct: 702  LTGEDWNAVMYDGI----MAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLAD 757

Query: 1425 QKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1458
             +     Q     E+++K     + L +KK  KP
Sbjct: 758  AESLNTAQKEEAEEKERKKIARKESLENKKNNKP 791



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 76/296 (25%), Positives = 135/296 (45%), Gaps = 61/296 (20%)

Query: 704 VNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNL-----VFTGIFTAEM 758
           ++++   PF D+ I + I  N + +A+ + P  E  S+  T  NL      F  IFT E 
Sbjct: 120 ISIVEWKPF-DIFILLAIFANCVALAI-YIPFPEDDSNS-TNHNLEKVEYAFLIIFTVET 176

Query: 759 VLKIIA----MDPYYYFQEGWNIFDGIIVSLSLMELGLSNV----EG------------L 798
            LKIIA    + P  Y + GWN+ D +IV + L  + L  +    EG            +
Sbjct: 177 FLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDV 236

Query: 799 SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GK 857
             LR+FR+LR  +L    P+L +++  I  ++  L ++ L++  ++ I+A++G++LF GK
Sbjct: 237 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGK 296

Query: 858 SYKECV-----------------------CKINDDCTLPRW--------HMNDFFHSFLI 886
            +K C                        C  N       W        + ++F  + L 
Sbjct: 297 MHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLT 356

Query: 887 VFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSD 941
           VF+ +  E W + ++   +  G  +  + F+ +++ G+  VLNL L +L   FS +
Sbjct: 357 VFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKE 412



 Score = 81.3 bits (199), Expect = 9e-15
 Identities = 65/262 (24%), Positives = 125/262 (47%), Gaps = 22/262 (8%)

Query: 1483 IMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLR-HYYFTIGWN 1541
            +++L+ LN +T+  E  +Q  ++T +    N V + LFT E ++K+ SL    YF   +N
Sbjct: 529  VIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFN 588

Query: 1542 IFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMM 1601
             FD  VV   I    L E+     +SP    V R  R+ RI ++ +    +  L+ +L+ 
Sbjct: 589  RFDCFVVCGGITETILVEL---EIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLN 645

Query: 1602 SLPALFNIGLLLFLVMFIYAIFGMSNF-AYVKKEAGIDDMFNFETFGNSMICLFQITTSA 1660
            S+ ++ ++ LLLFL + I+++ GM  F      +        F+ F  +++ +FQI T  
Sbjct: 646  SMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGE 705

Query: 1661 GWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAV 1720
             W+ ++           D    + G S  G      +   +F+   I    +++N+++A+
Sbjct: 706  DWNAVM----------YDGIMAYGGPSSSG-----MIVCIYFIILFICGNYILLNVFLAI 750

Query: 1721 ILENFSVATEESAEPLSEDDFE 1742
             ++N  +A  ES     +++ E
Sbjct: 751  AVDN--LADAESLNTAQKEEAE 770



 Score = 77.0 bits (188), Expect = 2e-13
 Identities = 80/374 (21%), Positives = 146/374 (39%), Gaps = 89/374 (23%)

Query: 1436 MTEEQKKYYNAMKKLGSKKPQKPIPRPA-----NKFQGMVFDFVTRQVFDISIMILICLN 1490
            +++ +++ Y   KK G+    +P          N  +      V  + FDI I++ I  N
Sbjct: 80   LSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFAN 139

Query: 1491 MVTMMVET---DDQGKYMTLVLSRINLVFIVLFTGEFVLKLVS---LRH--YYFTIGWNI 1542
             V + +     +D        L ++   F+++FT E  LK+++   L H   Y   GWN+
Sbjct: 140  CVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNL 199

Query: 1543 FDFVVVILSIVGMFLAEMIEKYFVSPTL--------FRVIRLARIGRILRLIKGAKGIRT 1594
             DFV+VI+ +  + L ++ ++                + +R  R+ R LRL+ G   ++ 
Sbjct: 200  LDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQV 259

Query: 1595 LLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-------------------------- 1628
            +L +++ ++  L +I LL+  V+ IYAI G+  F                          
Sbjct: 260  VLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAF 319

Query: 1629 ----------------AYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS 1672
                             +V    GI    NF+ F  +M+ +FQ  T  GW  +L  +   
Sbjct: 320  SGNGRQCTANGTECRSGWVGPNGGIT---NFDNFAFAMLTVFQCITMEGWTDVLYWM--- 373

Query: 1673 APPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEES 1732
                              D     +   +FVS +I     V+N+ + V+   FS   +E 
Sbjct: 374  -----------------NDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFS---KER 413

Query: 1733 AEPLSEDDFEMFYE 1746
             +  +  DF+   E
Sbjct: 414  EKAKARGDFQKLRE 427



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 61/264 (23%), Positives = 127/264 (48%), Gaps = 42/264 (15%)

Query: 717  ITICIVLNTLFMAMEHYPMTEQF-SSVLTVGNLVFTGIFTAEMVLKIIAMDPYY----YF 771
            I + I+L++  +A E    +  F +++L   +  FT IFT E++LK+     +     + 
Sbjct: 892  ILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFC 951

Query: 772  QEGWNIFDGIIVSLSLMELGL--SNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNS 829
            +  +N+ D ++V +SL+  G+  S +  + +LR  R+LR  +       L  +++ +  +
Sbjct: 952  RNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVA 1011

Query: 830  VGALGNLTLVLAIIVFIFAVVGMQLF-GKSYK----------EC-----VCKIND-DCTL 872
            +  +GN+ +V  ++ F+FA +G+QLF GK Y+          EC     + K  D D  +
Sbjct: 1012 IRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPV 1071

Query: 873  PR---WHMNDF-----FHSFLIVFRVLCGE-WIETMWDCMEVAGQTM---------CLIV 914
             R   W  +DF       + + +F V   E W   ++  ++  G+ +           I 
Sbjct: 1072 VRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIF 1131

Query: 915  FMLVMVIGNLVVLNLFLALLLSSF 938
            F++ ++I    ++N+F+  ++ +F
Sbjct: 1132 FIIYIIIVAFFMMNIFVGFVIVTF 1155



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 39/172 (22%), Positives = 83/172 (48%), Gaps = 19/172 (11%)

Query: 113  PLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPP------DWTKNVEYTFTGIYT 166
            P NP +     ++  S F  ++   I+ N + + + +        D    +   FTG++T
Sbjct: 1190 PKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFT 1249

Query: 167  FESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYV---------TEFVDLGNVSALRT 217
             E ++K++A     +   +  D WN  D  +++ + +         +E  +  +++  R 
Sbjct: 1250 VEMVLKVIA----FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRL 1305

Query: 218  FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
            FRV+R +K +S   G++T++   I+S + L  V +L      ++A+IG+Q+F
Sbjct: 1306 FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF 1357



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 35/154 (22%), Positives = 69/154 (44%), Gaps = 16/154 (10%)

Query: 130 FSMLIMCTILTNCVFMTLS--NPPDWTKNVE----YTFTGIYTFESLIKILARGFCLEDF 183
           F  L++  +  N + ++    N PDW   ++         ++T E L+K+ + G      
Sbjct: 525 FYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ---- 580

Query: 184 TFLRDPWNWLDFSVI------VMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIV 237
            +    +N  D  V+       +    E +    +S  R  R+LR  K       L  +V
Sbjct: 581 AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLV 640

Query: 238 GALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
            +L+ S+K ++ +++L    + +F+L+G+QLF G
Sbjct: 641 ASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGG 674



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 31/112 (27%), Positives = 57/112 (50%), Gaps = 12/112 (10%)

Query: 364 TSFDTFSWAFLSLFRLMTQDYWENLYQLTLRA------AGKTYMIFFVLVIFLGSFYLVN 417
           ++FD F  A L++F+++T + W  +    + A      +G    I+F+++   G++ L+N
Sbjct: 686 STFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLN 745

Query: 418 LILAVVA---MAYEEQNQATLEEAEQKEAE---FQQMLEQLKKQQEEAQAVA 463
           + LA+        E  N A  EEAE+KE +    ++ LE  K  + E   +A
Sbjct: 746 VFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIA 797


>gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform a [Homo sapiens]
          Length = 2353

 Score =  333 bits (855), Expect = 7e-91
 Identities = 206/656 (31%), Positives = 360/656 (54%), Gaps = 45/656 (6%)

Query: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1206
            R +C  ++ H  F+  ++  I L+   +A E   I+   T +  L  ++ +FT IF+ EM
Sbjct: 1284 RVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEM 1343

Query: 1207 LLKWVAYGF----QTYFTNAWCWLDFLIVDVSLVSLV---ANALGYSELGAIKSLRTLRA 1259
            ++K VA G       Y  ++W  LD L+V VSLV +V   A+A G   LG ++ LR LR 
Sbjct: 1344 MVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRT 1403

Query: 1260 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1319
            LRPLR +SR  G+++VV  L+ ++  I N++L+C  F++IF I+GV LF GKFY+C    
Sbjct: 1404 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPD 1463

Query: 1320 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1379
            T N      ++  + C+A     RW   K NFDN+G   ++L  +++  GW++IMY  +D
Sbjct: 1464 TRN------ISTKAQCRA--AHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLD 1515

Query: 1380 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1439
            +  V  QPV   N +M LYF+ F++  SFF LN+F+GV+++NF++ ++    ++     E
Sbjct: 1516 AVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEA-RRRE 1574

Query: 1440 QKKYYNAMKKLGSKKP-----QKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTM 1494
            +K+     ++  S  P     ++P     +  +  +    T    D+ I  +IC+N++TM
Sbjct: 1575 EKRLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITM 1634

Query: 1495 MVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLR-HYYFTIGWNIFDFVVVILSIV 1553
             +E  +Q K +   L   N VF ++F  E  LKLV+     +F   WN  D  +V+LS++
Sbjct: 1635 SMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLM 1694

Query: 1554 GMFL--AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGL 1611
            G+ L   EM     ++PT+ R++R+ RI R+L+L+K A G+R LL  ++ +LP + N+GL
Sbjct: 1695 GITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGL 1754

Query: 1612 LLFLVMFIYAIFGMSNFAYVKKE-----AGIDDMFNFETFGNSMICLFQITTSAGWDGLL 1666
            L  L+ FIYA  G+  F  ++        G+     F  FG + + LF+++T   W+G++
Sbjct: 1755 LFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIM 1814

Query: 1667 APILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFS 1726
               L     +C  +  H  S +      P++   +FV++++++  V+VN+ +AV++++  
Sbjct: 1815 KDTLR----ECSREDKHCLSYL------PALSPVYFVTFVLVAQFVLVNVVVAVLMKHLE 1864

Query: 1727 VATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSK---LSDFAAALDPPLLIAK 1779
             + +E+ E  +E D E+  E+ +   P + + ++  +     +   A D P L+A+
Sbjct: 1865 ESNKEARED-AELDAEIELEMAQ--GPGSARRVDADRPPLPQESPGARDAPNLVAR 1917



 Score =  141 bits (355), Expect = 7e-33
 Identities = 83/258 (32%), Positives = 145/258 (56%), Gaps = 9/258 (3%)

Query: 697  WLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTA 756
            W+     +  IV   +    I + I++NTL M +E++   E+ ++ L + N+VFT +F  
Sbjct: 779  WVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFAL 838

Query: 757  EMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSW 816
            EM+LK++A  P  Y +  +NIFDGIIV +S+ E+      GLSVLR+FRLLRV KL +  
Sbjct: 839  EMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFL 898

Query: 817  PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP-RW 875
            P L   + ++  ++  +     +L + +FIF+++GM LFG  +     K +   T+P R 
Sbjct: 899  PALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFS---LKTDTGDTVPDRK 955

Query: 876  HMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALL 934
            + +    + + VF++L  E W   +++ M  +  +   + F+ +M  GN V+ NL +A+L
Sbjct: 956  NFDSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSSWAALYFVALMTFGNYVLFNLLVAIL 1014

Query: 935  LSSFSSD---NLAATDDD 949
            +  F ++   N + TD+D
Sbjct: 1015 VEGFQAEGDANRSDTDED 1032



 Score =  132 bits (332), Expect = 3e-30
 Identities = 109/470 (23%), Positives = 204/470 (43%), Gaps = 95/470 (20%)

Query: 104 ATSALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTK------NV 157
           A +  + L      R   ++++ +  F  + M  I+ NCV + +  P +  +      N+
Sbjct: 76  AATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNI 135

Query: 158 EYTFTGI----YTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVS 213
              F       +  E +IK++A G   +   +L D WN LDF ++V   +   +D  NVS
Sbjct: 136 LEAFDAFIFAFFAVEMVIKMVALGLFGQK-CYLGDTWNRLDFFIVVAGMMEYSLDGHNVS 194

Query: 214 --ALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
             A+RT RVLR L+ I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G
Sbjct: 195 LSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254

Query: 272 NLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQ 331
            LRN+C      DSAF  N          +N TF+                 ++   +G+
Sbjct: 255 LLRNRCF----LDSAFVRN----------NNLTFLR---------------PYYQTEEGE 285

Query: 332 KDPLLCGNGSDAGQ---------------CPEGY-------------------------- 350
           ++P +C +  D G                C  G+                          
Sbjct: 286 ENPFICSSRRDNGMQKCSHIPGRRELRMPCTLGWEAYTQPQAEGVGAARNACINWNQYYN 345

Query: 351 ICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFL 410
           +C     NP+ G  +FD   +A++++F+++T + W ++    + A      I+F+L+I +
Sbjct: 346 VCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIV 405

Query: 411 GSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASR 470
           GSF+++NL L V+A  +          +E K+ E Q M EQ  +       +A+ S    
Sbjct: 406 GSFFMINLCLVVIATQF----------SETKQRESQLMREQRARHLSNDSTLASFSEPGS 455

Query: 471 DFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGER 520
            +  +  L  +     +  + S +    W++R +K+     ++G   G R
Sbjct: 456 CYEEL--LKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQGPGHR 503



 Score =  115 bits (287), Expect = 5e-25
 Identities = 131/634 (20%), Positives = 260/634 (41%), Gaps = 91/634 (14%)

Query: 365  SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVA 424
            +FD+  WA +++F+++TQ+ W  +    + +      ++FV ++  G++ L NL++A++ 
Sbjct: 956  NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILV 1015

Query: 425  MAYEEQNQATLEEAEQKEAE--FQQMLEQLKK-QQEEAQAVAAASAASRDFSGIGGLGEL 481
              ++ +  A   + ++ +    F++   +L++ Q  E +  + A   +    G G L   
Sbjct: 1016 EGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPP 1075

Query: 482  LESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFSM 541
            L   + A+ + +                            S P  ++  S+  S    S 
Sbjct: 1076 LIMCTAATPMPTPK--------------------------SSPFLDAAPSLPDSRRGSSS 1109

Query: 542  DGNRLTSDKKFCSPHQSLLSIRGSLFSPRR--NSKTSIFSFRGRAKDVGSENDFADDEHS 599
             G+    D+K   P  SL S   + + P    +S+ S +S  GRA  +       + E  
Sbjct: 1110 SGDPPLGDQK---PPASLRSSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESL 1166

Query: 600  TFEDSESRRDSLFVPHRHGERRNSNGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVS- 658
               + +   D      R      +        +  R L    +      D  G+  A+  
Sbjct: 1167 LSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALPS 1226

Query: 659  -----IASILTNTMEELEESRQKC-----------PPCWYRFANVFLIWDCCDAWLKVKH 702
                 I S   +  E  ++S   C            P W R    + ++       + + 
Sbjct: 1227 DFFLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALY-LFSPQNRFRV 1285

Query: 703  LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLTVGNLVFTGIFTAEMV 759
                ++     D  + + I LN + +A+E  P  +  S+    L+V N +FT IF AEM+
Sbjct: 1286 SCQKVITHKMFDHVVLVFIFLNCVTIALER-PDIDPGSTERVFLSVSNYIFTAIFVAEMM 1344

Query: 760  LKIIAMD----PYYYFQEGWNIFDGIIVSLSLMEL--------GLSNVEGLSVLRSFRLL 807
            +K++A+      + Y Q  WN+ DG++V +SL+++        G   +  L VLR  R L
Sbjct: 1345 VKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTL 1404

Query: 808  RVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSY------- 859
            R  ++    P L ++++ + +S+  +GN+ L+      IF ++G+QLF GK Y       
Sbjct: 1405 RPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDT 1464

Query: 860  ----KECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGE--WIETMWDCMEVAG------ 907
                 +  C+      + R +  D     L+   VL  +  W+  M+D ++  G      
Sbjct: 1465 RNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPV 1524

Query: 908  ---QTMCLIVFMLVMVIGNLVVLNLFLALLLSSF 938
                   L+ F+  ++I +  VLN+F+ +++ +F
Sbjct: 1525 QNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1558



 Score =  109 bits (272), Expect = 3e-23
 Identities = 75/260 (28%), Positives = 128/260 (49%), Gaps = 27/260 (10%)

Query: 712  FVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYF 771
            ++DL IT  I +N + M+MEHY   +     L   N VFT +F  E  LK++A     +F
Sbjct: 1618 YLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFF 1677

Query: 772  QEGWNIFDGIIVSLSLMELGLSNVEG----------LSVLRSFRLLRVFKLAKSWPTLNM 821
            ++ WN  D  IV LSLM + L  +E           + ++R  R+ RV KL K    +  
Sbjct: 1678 KDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRA 1737

Query: 822  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWH--MND 879
            L+  +  ++  +GNL L+  ++ FI+A +G++LFG+      C  ++ C     H   ++
Sbjct: 1738 LLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR----LECSEDNPCEGLSRHATFSN 1793

Query: 880  FFHSFLIVFRVLCGE-WIETMWDCMEVAGQ--TMCL--------IVFMLVMVIGNLVVLN 928
            F  +FL +FRV  G+ W   M D +    +    CL        + F+  +++   V++N
Sbjct: 1794 FGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVN 1853

Query: 929  LFLALLLSSFSSDNLAATDD 948
            + +A+L+      N  A +D
Sbjct: 1854 VVVAVLMKHLEESNKEARED 1873



 Score =  106 bits (265), Expect = 2e-22
 Identities = 76/291 (26%), Positives = 138/291 (47%), Gaps = 38/291 (13%)

Query: 1462 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD--DQGKYMTLVLSRINLVFIVL 1519
            P N+F+      +T ++FD  +++ I LN VT+ +E    D G    + LS  N +F  +
Sbjct: 1279 PQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAI 1338

Query: 1520 FTGEFVLKLVSL-----RHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVI 1574
            F  E ++K+V+L      H Y    WN+ D ++V++S+V + +A           + RV+
Sbjct: 1339 FVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVL 1398

Query: 1575 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF------ 1628
            RL R  R LR+I  A G++ ++  L+ SL  + NI L+      I+ I G+  F      
Sbjct: 1399 RLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYY 1458

Query: 1629 --------------AYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAP 1674
                                  +   +NF+  G +++ LF +++  GW  ++   L++  
Sbjct: 1459 CEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVG 1518

Query: 1675 PDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1725
             D  P   H          NP + + +F+S+++I    V+NM++ V++ENF
Sbjct: 1519 VDQQPVQNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1558



 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 79/280 (28%), Positives = 128/280 (45%), Gaps = 28/280 (10%)

Query: 9    PGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFIYGDI 68
            PGP +  L   ESL   + R     A  P K +D D +    P SD        F+  D 
Sbjct: 1186 PGPRATPLRRAESL---DPRPLRPAALPPTKCRDRDGQVVALP-SDF-------FLRIDS 1234

Query: 69   PPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHS 128
              E  +E  +D +     +   ++        R     ALY+ +P N  R    K++ H 
Sbjct: 1235 HREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHK 1294

Query: 129  LFSMLIMCTILTNCVFMTLSNP---PDWTKNV-----EYTFTGIYTFESLIKILARGFCL 180
            +F  +++  I  NCV + L  P   P  T+ V      Y FT I+  E ++K++A G   
Sbjct: 1295 MFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLS 1354

Query: 181  EDFTFLRDPWNWLDFSVIVMAYVTEFVD---------LGNVSALRTFRVLRALKTISVIP 231
             +  +L+  WN LD  +++++ V   V          LG +  LR  R LR L+ IS  P
Sbjct: 1355 GEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAP 1414

Query: 232  GLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
            GLK +V  LI S++ + +++++      +F ++G+QLF G
Sbjct: 1415 GLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKG 1454



 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 74/286 (25%), Positives = 133/286 (46%), Gaps = 40/286 (13%)

Query: 1140 GKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFT 1199
            G++W         IV+  +F   I+  IL+++ ++  E  Y EQ + +   LE ++ VFT
Sbjct: 776  GRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVE--YHEQPEELTNALEISNIVFT 833

Query: 1200 YIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRA 1259
             +F LEMLLK +A G   Y  N +   D +IV +S+  +V  A      G +  LRT R 
Sbjct: 834  SMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQA-----DGGLSVLRTFRL 888

Query: 1260 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1319
            LR L+ +     +R  +  LV  + ++     + ++F  IFSI+G++LF  KF    ++ 
Sbjct: 889  LRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKF----SLK 944

Query: 1320 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1379
            T     + D                   + NFD++    + + Q+ T + W  ++Y  + 
Sbjct: 945  TDTGDTVPD-------------------RKNFDSLLWAIVTVFQILTQEDWNVVLYNGMA 985

Query: 1380 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1425
            S           + +  LYFV  + FG++   NL + ++++ F  +
Sbjct: 986  S----------TSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021



 Score = 91.3 bits (225), Expect = 8e-18
 Identities = 61/174 (35%), Positives = 93/174 (53%), Gaps = 19/174 (10%)

Query: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRKTIKTMLEYADKVFTYIF 1202
            R  C  +V + WFE   + +I+L+   L      ED+     +    +LE  D      F
Sbjct: 90   RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERC--NILEAFDAFIFAFF 147

Query: 1203 ILEMLLKWVA---YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELG---AIKSLRT 1256
             +EM++K VA   +G + Y  + W  LDF IV       VA  + YS  G   ++ ++RT
Sbjct: 148  AVEMVIKMVALGLFGQKCYLGDTWNRLDFFIV-------VAGMMEYSLDGHNVSLSAIRT 200

Query: 1257 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1310
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 201  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 73/290 (25%), Positives = 131/290 (45%), Gaps = 41/290 (14%)

Query: 1466 FQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFV 1525
            F G +   V  + F   IM+ I +N ++M VE  +Q + +T  L   N+VF  +F  E +
Sbjct: 782  FSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEML 841

Query: 1526 LKLVSLRHY-YFTIGWNIFDFVVVILS---IVGMFLAEMIEKYFVSPTLFRVIRLARIGR 1581
            LKL++     Y    +NIFD ++V++S   IVG            +     V+R  R+ R
Sbjct: 842  LKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQ-----------ADGGLSVLRTFRLLR 890

Query: 1582 ILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKKEAG-- 1636
            +L+L++    +R  L  L+ ++  +     LL L +FI++I GM  F     +K + G  
Sbjct: 891  VLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDT 950

Query: 1637 IDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPS 1696
            + D  NF++   +++ +FQI T   W+ +L                       G     S
Sbjct: 951  VPDRKNFDSLLWAIVTVFQILTQEDWNVVL---------------------YNGMASTSS 989

Query: 1697 VGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE 1746
                +FV+ +     V+ N+ +A+++E F    + +     ED   + +E
Sbjct: 990  WAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 41/132 (31%), Positives = 70/132 (53%), Gaps = 13/132 (9%)

Query: 1346 NVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIF 1405
            N  +NFDN+G  ++A+ QV T +GW+DIMY  +D+           + Y ++YF++ II 
Sbjct: 356  NGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDA----------HSFYNFIYFILLIIV 405

Query: 1406 GSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANK 1465
            GSFF +NL + VI   F++ K++   +   M E++ ++ +    L S            K
Sbjct: 406  GSFFMINLCLVVIATQFSETKQR---ESQLMREQRARHLSNDSTLASFSEPGSCYEELLK 462

Query: 1466 FQGMVFDFVTRQ 1477
            + G +F  V R+
Sbjct: 463  YVGHIFRKVKRR 474



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 48/155 (30%), Positives = 84/155 (54%), Gaps = 13/155 (8%)

Query: 123 KILVHSLFSMLIMCTILTNCVFMTLS---NPPDWTKNVEYT---FTGIYTFESLIKILAR 176
           +I+    FS  IM  IL N + M +     P + T  +E +   FT ++  E L+K+LA 
Sbjct: 788 RIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLAC 847

Query: 177 GFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 234
           G       ++R+P+N  D  +IV+  V E V    G +S LRTFR+LR LK +  +P L+
Sbjct: 848 G----PLGYIRNPYNIFD-GIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALR 902

Query: 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
             +  L++++  ++    L +  + +F+++G+ LF
Sbjct: 903 RQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLF 937



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 42/157 (26%), Positives = 80/157 (50%), Gaps = 8/157 (5%)

Query: 707 IVMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 762
           +V +P+ +    + I+LN + + M    E      +  ++L   +      F  EMV+K+
Sbjct: 96  LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155

Query: 763 IAMDPY---YYFQEGWNIFDGIIVSLSLMELGLSNVE-GLSVLRSFRLLRVFKLAKSWPT 818
           +A+  +    Y  + WN  D  IV   +ME  L      LS +R+ R+LR  +     P+
Sbjct: 156 VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPS 215

Query: 819 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 855
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 216 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 44/198 (22%), Positives = 95/198 (47%), Gaps = 24/198 (12%)

Query: 115  NPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLS--NPP----DWTKNVEYTFTGIYTFE 168
            +P R+    +       + I   I  N + M++   N P    +  K   Y FT ++ FE
Sbjct: 1604 SPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFE 1663

Query: 169  SLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSA-----------LRT 217
            + +K++A GF      F +D WN LD ++++++ +   ++   +SA           +R 
Sbjct: 1664 AALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRV 1719

Query: 218  FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC 277
             R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    ++A +G++LF    R +C
Sbjct: 1720 LRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFG---RLEC 1776

Query: 278  LQWPPSDSAFETNTTSYF 295
             +  P +      T S F
Sbjct: 1777 SEDNPCEGLSRHATFSNF 1794



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 48/159 (30%), Positives = 75/159 (47%), Gaps = 15/159 (9%)

Query: 1479 FDISIMILICLNMVTMMV----ETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHY 1534
            F+   M++I LN VT+ +    E  + G     +L   +      F  E V+K+V+L  +
Sbjct: 102  FEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLF 161

Query: 1535 ----YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1590
                Y    WN  DF +V+  ++   L    + + VS      IR  R+ R LR I    
Sbjct: 162  GQKCYLGDTWNRLDFFIVVAGMMEYSL----DGHNVS---LSAIRTVRVLRPLRAINRVP 214

Query: 1591 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1629
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 215  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253



 Score = 55.5 bits (132), Expect = 5e-07
 Identities = 39/141 (27%), Positives = 65/141 (46%), Gaps = 19/141 (13%)

Query: 345  QCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGK------ 398
            +C E   C    R     + +F  F  AFL+LFR+ T D W  + + TLR   +      
Sbjct: 1775 ECSEDNPCEGLSR-----HATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCL 1829

Query: 399  TYM-----IFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAE---QKEAEFQQMLE 450
            +Y+     ++FV  + +  F LVN+++AV+    EE N+   E+AE   + E E  Q   
Sbjct: 1830 SYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEMAQGPG 1889

Query: 451  QLKKQQEEAQAVAAASAASRD 471
              ++   +   +   S  +RD
Sbjct: 1890 SARRVDADRPPLPQESPGARD 1910



 Score = 33.1 bits (74), Expect = 2.7
 Identities = 16/59 (27%), Positives = 38/59 (64%), Gaps = 2/59 (3%)

Query: 882 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 939
           ++++ +F+V+  E W++ M+  M+ A      I F+L++++G+  ++NL L ++ + FS
Sbjct: 366 YAWIAIFQVITLEGWVDIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 423



 Score = 32.7 bits (73), Expect = 3.6
 Identities = 18/97 (18%), Positives = 40/97 (41%), Gaps = 21/97 (21%)

Query: 1642 NFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFF 1701
            NF+  G + I +FQ+ T  GW  ++  ++++                     +      +
Sbjct: 360  NFDNIGYAWIAIFQVITLEGWVDIMYYVMDA---------------------HSFYNFIY 398

Query: 1702 FVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1738
            F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 399  FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 435


>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
            isoform 3 [Homo sapiens]
          Length = 2343

 Score =  333 bits (853), Expect = 1e-90
 Identities = 199/609 (32%), Positives = 338/609 (55%), Gaps = 43/609 (7%)

Query: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1206
            R  C+ I+ H  F+  ++ +I L+   +A E   I+     +  L  ++ +FT +F+ EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302

Query: 1207 LLKWVAYGF----QTYFTNAWCWLDFLIVDVSLVSLVANAL---GYSELGAIKSLRTLRA 1259
             +K VA G+    Q Y  ++W  LD L+V +S++ ++ + +   G   LG ++ LR LR 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 1260 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1319
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1422

Query: 1320 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1379
            T N      + N SDC       RW   K NFDN+G   ++L  +A+  GW+DIMY  +D
Sbjct: 1423 TRN------ITNKSDCAEASY--RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLD 1474

Query: 1380 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1439
            +  V  QP+   N +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++     E
Sbjct: 1475 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRRE 1533

Query: 1440 QKKYYNAMKKLGSKKPQ------KPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVT 1493
            +K+     KK  SK+ Q      KP     ++F+ +V    T    D+ I  +I LN+VT
Sbjct: 1534 EKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVT 1593

Query: 1494 MMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLR-HYYFTIGWNIFDFVVVILSI 1552
            M +E   Q + +   L   N +F V+F  E V KLV+     +F   WN  D  +V+LSI
Sbjct: 1594 MAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSI 1653

Query: 1553 VGMFL--AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIG 1610
            +G+ L   E+     ++PT+ R++R+ RI R+L+L+K A G+R LL  +M +LP + N+G
Sbjct: 1654 MGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLG 1713

Query: 1611 LLLFLVMFIYAIFGMSNFAYVKKE-----AGIDDMFNFETFGNSMICLFQITTSAGWDGL 1665
            LL  L+ FI+A  G+  F  ++ +      G+     F  FG + + LF+++T   W+G+
Sbjct: 1714 LLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGI 1773

Query: 1666 LAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1725
            +   L     DCD ++          C N  +   +FVS+++ +  V+VN+ IAV++++ 
Sbjct: 1774 MKDTLR----DCDQES---------TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHL 1820

Query: 1726 SVATEESAE 1734
              + +E+ E
Sbjct: 1821 EESNKEAKE 1829



 Score =  140 bits (354), Expect = 9e-33
 Identities = 78/247 (31%), Positives = 139/247 (56%), Gaps = 7/247 (2%)

Query: 697 WLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTA 756
           W  +      IV   +    I I I++NTL M +E++   E+ ++ L + N+VFT +F  
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 757 EMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSW 816
           EM+LK++   P+ Y +  +NIFDG+IV +S+ E+      GLSVLR+FRL+RV KL +  
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 817 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP-RW 875
           P L   + ++  ++  +    ++L + +FIF+++GM LFG  +        D  TLP R 
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF----ASERDGDTLPDRK 904

Query: 876 HMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALL 934
           + +    + + VF++L  E W + +++ M  +  +   + F+ +M  GN V+ NL +A+L
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAIL 963

Query: 935 LSSFSSD 941
           +  F ++
Sbjct: 964 VEGFQAE 970



 Score =  122 bits (307), Expect = 3e-27
 Identities = 97/377 (25%), Positives = 171/377 (45%), Gaps = 48/377 (12%)

Query: 118 RKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPD----------WTKNVEYTFTGIYTF 167
           R   ++ + +  F  + M  IL NCV + +  P +            +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 168 ESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVS--ALRTFRVLRALK 225
           E ++K++A G   +   +L D WN LDF +++   +   +DL NVS  A+RT RVLR L+
Sbjct: 131 EMVVKMVALGIFGKK-CYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 226 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDS 285
            I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LRN+C        
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249

Query: 286 AFETNTTSYFNGTMDSNGTFV------NVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGN 339
               +   Y+    +    F+      N   S  +     GD        G   P  CG 
Sbjct: 250 PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGD-------GGGGPP--CGL 300

Query: 340 GSDAGQCPEGYICV---------KAG-RNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLY 389
             +A        CV          AG  NP  G  +FD   +A++++F+++T + W ++ 
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 390 QLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQML 449
              + A      I+F+L+I +GSF+++NL L V+A  +          +E K+ E Q M 
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF----------SETKQRESQLMR 410

Query: 450 EQLKKQQEEAQAVAAAS 466
           EQ  +    A  +A+ S
Sbjct: 411 EQRVRFLSNASTLASFS 427



 Score =  119 bits (297), Expect = 4e-26
 Identities = 143/643 (22%), Positives = 270/643 (41%), Gaps = 99/643 (15%)

Query: 365  SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVA 424
            +FD+  WA +++F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 425  MAYEEQNQATLEEAEQK----------EAEFQQMLEQLKKQQEEAQAV-------AAASA 467
              ++ +  A   E+E            + +    L  L +  E  +++        AA+ 
Sbjct: 965  EGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATP 1024

Query: 468  ASRDFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSE 527
             S   S   GLGE L  +S  +  SS SA+       K         ++       P S 
Sbjct: 1025 MSLPKSTSTGLGEALGPASRRTS-SSGSAEPGAAHEMKSPPSARSSPHS-------PWSA 1076

Query: 528  SEDSVKRSSFLFSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDV 587
            +     R S   S+        +      +SLLS  G        S     S   RA   
Sbjct: 1077 ASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEES-----SEEERASPA 1131

Query: 588  GSENDFADDEHSTFEDSESRRDSLFVPHRHGERRNSNGTTTETEVRKRRLSSYQISMEML 647
            GS++          + S    D+L VP  H    +  G+ +E +    + +S +++  + 
Sbjct: 1132 GSDHRHRGSLEREAKSSFDLPDTLQVPGLH-RTASGRGSASEHQDCNGKSASGRLARALR 1190

Query: 648  EDSSGRQRAVSIASILTNTMEELEESRQKCPPCWYRFANVFLIWDCC---DAWL------ 698
             D               +  +E   S+ +    W R      +  CC   D+W       
Sbjct: 1191 PDDPPLDG--------DDADDEGNLSKGERVRAWIRAR----LPACCLERDSWSAYIFPP 1238

Query: 699  --KVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLTVGNLVFTGI 753
              + + L + I+     D  + + I LN + +AME  P  +  S+    LT+ N +FT +
Sbjct: 1239 QSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTAV 1297

Query: 754  FTAEMVLKIIAMDPYY----YFQEGWNIFDGIIVSLSLMELGLSNVEG--------LSVL 801
            F AEM +K++A+   +    Y +  WN+ DG++V +S++++ +S V          L VL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357

Query: 802  RSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYK 860
            R  R LR  ++      L ++++ + +S+  +GN+ ++      IF ++G+QLF GK + 
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF- 1416

Query: 861  ECVCKIND--------DCTLP--RW--HMNDF--FHSFLIVFRVLCGE--WIETMWDCME 904
              VC+  D        DC     RW  H  +F      L+   VL  +  W++ M+D ++
Sbjct: 1417 --VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLD 1474

Query: 905  VAG---------QTMCLIVFMLVMVIGNLVVLNLFLALLLSSF 938
              G             L+ F+  ++I    VLN+F+ +++ +F
Sbjct: 1475 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517



 Score =  110 bits (274), Expect = 2e-23
 Identities = 79/266 (29%), Positives = 131/266 (49%), Gaps = 24/266 (9%)

Query: 703  LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 762
            LV+ +    ++DL IT  I LN + MAMEHY   +     L + N +FT IF  E V K+
Sbjct: 1569 LVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKL 1628

Query: 763  IAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEG----------LSVLRSFRLLRVFKL 812
            +A     +FQ+ WN  D  IV LS+M + L  +E           + ++R  R+ RV KL
Sbjct: 1629 VAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKL 1688

Query: 813  AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTL 872
             K    +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +  C     C  
Sbjct: 1689 LKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG----DLECDETHPCEG 1744

Query: 873  PRWH--MNDFFHSFLIVFRVLCGE-W----IETMWDCMEVA---GQTMCLIVFMLVMVIG 922
               H    +F  +FL +FRV  G+ W     +T+ DC + +      +  I F+  ++  
Sbjct: 1745 LGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1804

Query: 923  NLVVLNLFLALLLSSFSSDNLAATDD 948
              V++N+ +A+L+      N  A ++
Sbjct: 1805 QFVLVNVVIAVLMKHLEESNKEAKEE 1830



 Score =  105 bits (262), Expect = 4e-22
 Identities = 87/393 (22%), Positives = 163/393 (41%), Gaps = 90/393 (22%)

Query: 109  YILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVE--------YT 160
            YI  P +  R +  +I+ H +F  +++  I  NC+ + +  P     + E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 161  FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVD---------LGN 211
            FT ++  E  +K++A G+C  +  +LR  WN LD  +++++ +   V          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 212  VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 272  NLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQ 331
                                                                 F+V  G+
Sbjct: 1414 K----------------------------------------------------FFVCQGE 1421

Query: 332  KDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQL 391
             D     N SD  +    ++  K      Y +   D    A +SLF L ++D W ++   
Sbjct: 1422 -DTRNITNKSDCAEASYRWVRHK------YNF---DNLGQALMSLFVLASKDGWVDIMYD 1471

Query: 392  TLRAAG----------KTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQ-ATLEEAEQ 440
             L A G             +++F+  + + +F+++N+ + VV   + +  Q    EEA +
Sbjct: 1472 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531

Query: 441  KEAEFQQMLEQLKKQQEEAQAVAAASAASRDFS 473
            +E +  + LE+ ++ +E+  A A       D+S
Sbjct: 1532 REEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYS 1564



 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 70/283 (24%), Positives = 132/283 (46%), Gaps = 41/283 (14%)

Query: 1143 WWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIF 1202
            W  +  T   IV+  +F   I+  IL+++ ++  E  Y EQ + +   LE ++ VFT +F
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLF 786

Query: 1203 ILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRP 1262
             LEMLLK + YG   Y  N +   D +IV +S+  +V       + G +  LRT R +R 
Sbjct: 787  ALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRV 841

Query: 1263 LRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGN 1322
            L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF          
Sbjct: 842  LKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA--------- 892

Query: 1323 MFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRD 1382
                 D + L D             + NFD++    + + Q+ T + W  ++Y  + S  
Sbjct: 893  --SERDGDTLPD-------------RKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST- 936

Query: 1383 VKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1425
                     + +  LYF+  + FG++   NL + ++++ F  +
Sbjct: 937  ---------SSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970



 Score = 91.3 bits (225), Expect = 8e-18
 Identities = 61/174 (35%), Positives = 96/174 (55%), Gaps = 19/174 (10%)

Query: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRKTIKTMLEYADKVFTYIF 1202
            R  C   V + WFE   + +ILL+   L      EDI  + ++  + +  + D +F + F
Sbjct: 71   RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF-F 128

Query: 1203 ILEMLLKWVA---YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYS---ELGAIKSLRT 1256
             +EM++K VA   +G + Y  + W  LDF IV       +A  L YS   +  +  ++RT
Sbjct: 129  AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAGMLEYSLDLQNVSFSAVRT 181

Query: 1257 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1310
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 182  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235



 Score = 85.5 bits (210), Expect = 5e-16
 Identities = 71/273 (26%), Positives = 129/273 (47%), Gaps = 35/273 (12%)

Query: 1474 VTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRH 1533
            V  + F   IMI I +N ++M +E  +Q + +T  L   N+VF  LF  E +LKL+    
Sbjct: 740  VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799

Query: 1534 Y-YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1592
            + Y    +NIFD V+V++S+      E++ +     ++ R  RL R+   L+L++    +
Sbjct: 800  FGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPAL 851

Query: 1593 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS----NFAYVKKEAGIDDMFNFETFGN 1648
            +  L  LM ++  +    +LL L +FI++I GM      FA  +    + D  NF++   
Sbjct: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLW 911

Query: 1649 SMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIII 1708
            +++ +FQI T   W+ +L                       G     S    +F++ +  
Sbjct: 912  AIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIALMTF 950

Query: 1709 SFLVVVNMYIAVILENFSVATEESAEPLSEDDF 1741
               V+ N+ +A+++E F  A  ++ +  SE DF
Sbjct: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 72.0 bits (175), Expect = 5e-12
 Identities = 35/104 (33%), Positives = 61/104 (58%), Gaps = 13/104 (12%)

Query: 1349 VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSF 1408
            +NFDN+G  ++A+ QV T +GW+DIMY  +D+           + Y ++YF++ II GSF
Sbjct: 335  INFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNFIYFILLIIVGSF 384

Query: 1409 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1452
            F +NL + VI   F++ K++   +   M E++ ++ +    L S
Sbjct: 385  FMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 47/155 (30%), Positives = 84/155 (54%), Gaps = 13/155 (8%)

Query: 123 KILVHSLFSMLIMCTILTNCVFMTLS---NPPDWTKNVEYT---FTGIYTFESLIKILAR 176
           KI+    F   IM  IL N + M +     P + T  +E +   FT ++  E L+K+L  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 177 GFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 234
           G     F ++++P+N  D  VIV+  V E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 47/175 (26%), Positives = 88/175 (50%), Gaps = 11/175 (6%)

Query: 708 VMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKII 763
           V +P+ +    + I+LN + + M    E      Q   +L   +      F  EMV+K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 764 AMDPY---YYFQEGWNIFDGIIVSLSLME--LGLSNVEGLSVLRSFRLLRVFKLAKSWPT 818
           A+  +    Y  + WN  D  IV   ++E  L L NV   S +R+ R+LR  +     P+
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLRPLRAINRVPS 196

Query: 819 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP 873
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+    +   C + ++ +LP
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN-RCFLPENFSLP 250



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 68/313 (21%), Positives = 130/313 (41%), Gaps = 87/313 (27%)

Query: 155  KNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSA 214
            K   Y FT I+  ES+ K++A GF      F +D WN LD ++++++ +   ++   V+A
Sbjct: 1610 KICNYIFTVIFVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNA 1665

Query: 215  -----------LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFAL 263
                       +R  R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA 
Sbjct: 1666 SLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAA 1725

Query: 264  IGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFN-WKDYIGDD 322
            +G++LF G+L  +C +  P +              +  + TF N  M+    ++   GD+
Sbjct: 1726 LGVELF-GDL--ECDETHPCEG-------------LGRHATFRNFGMAFLTLFRVSTGDN 1769

Query: 323  SHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQ 382
             +  + D  +D            C +   C     +P Y + SF                
Sbjct: 1770 WNGIMKDTLRD------------CDQESTCYNTVISPIY-FVSF---------------- 1800

Query: 383  DYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKE 442
                                     +    F LVN+++AV+    EE N+   EEAE  E
Sbjct: 1801 -------------------------VLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE-LE 1834

Query: 443  AEFQQMLEQLKKQ 455
            AE +  ++ L  Q
Sbjct: 1835 AELELEMKTLSPQ 1847



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 46/159 (28%), Positives = 71/159 (44%), Gaps = 15/159 (9%)

Query: 1479 FDISIMILICLNMVTMMV----ETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSL--- 1531
            F+   M++I LN VT+ +    E          +L   +      F  E V+K+V+L   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1532 -RHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1590
             +  Y    WN  DF +VI  ++   L        +    F  +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAINRVP 195

Query: 1591 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1629
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 33.1 bits (74), Expect = 2.7
 Identities = 16/59 (27%), Positives = 38/59 (64%), Gaps = 2/59 (3%)

Query: 882 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 939
           ++++ +F+V+  E W++ M+  M+ A      I F+L++++G+  ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 399



 Score = 32.7 bits (73), Expect = 3.6
 Identities = 23/116 (19%), Positives = 46/116 (39%), Gaps = 25/116 (21%)

Query: 1627 NFAYVKKEAGIDDMF----NFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTI 1682
            N  Y    AG  + F    NF+  G + I +FQ+ T  GW  ++  ++++          
Sbjct: 317  NQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------- 366

Query: 1683 HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1738
                       +      +F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 367  -----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411


>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
            isoform 12 [Homo sapiens]
          Length = 2250

 Score =  333 bits (853), Expect = 1e-90
 Identities = 199/609 (32%), Positives = 338/609 (55%), Gaps = 43/609 (7%)

Query: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1206
            R  C+ I+ H  F+  ++ +I L+   +A E   I+     +  L  ++ +FT +F+ EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302

Query: 1207 LLKWVAYGF----QTYFTNAWCWLDFLIVDVSLVSLVANAL---GYSELGAIKSLRTLRA 1259
             +K VA G+    Q Y  ++W  LD L+V +S++ ++ + +   G   LG ++ LR LR 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 1260 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1319
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1422

Query: 1320 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1379
            T N      + N SDC       RW   K NFDN+G   ++L  +A+  GW+DIMY  +D
Sbjct: 1423 TRN------ITNKSDCAEASY--RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLD 1474

Query: 1380 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1439
            +  V  QP+   N +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++     E
Sbjct: 1475 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRRE 1533

Query: 1440 QKKYYNAMKKLGSKKPQ------KPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVT 1493
            +K+     KK  SK+ Q      KP     ++F+ +V    T    D+ I  +I LN+VT
Sbjct: 1534 EKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVT 1593

Query: 1494 MMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLR-HYYFTIGWNIFDFVVVILSI 1552
            M +E   Q + +   L   N +F V+F  E V KLV+     +F   WN  D  +V+LSI
Sbjct: 1594 MAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSI 1653

Query: 1553 VGMFL--AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIG 1610
            +G+ L   E+     ++PT+ R++R+ RI R+L+L+K A G+R LL  +M +LP + N+G
Sbjct: 1654 MGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLG 1713

Query: 1611 LLLFLVMFIYAIFGMSNFAYVKKE-----AGIDDMFNFETFGNSMICLFQITTSAGWDGL 1665
            LL  L+ FI+A  G+  F  ++ +      G+     F  FG + + LF+++T   W+G+
Sbjct: 1714 LLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGI 1773

Query: 1666 LAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1725
            +   L     DCD ++          C N  +   +FVS+++ +  V+VN+ IAV++++ 
Sbjct: 1774 MKDTLR----DCDQES---------TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHL 1820

Query: 1726 SVATEESAE 1734
              + +E+ E
Sbjct: 1821 EESNKEAKE 1829



 Score =  140 bits (354), Expect = 9e-33
 Identities = 78/247 (31%), Positives = 139/247 (56%), Gaps = 7/247 (2%)

Query: 697 WLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTA 756
           W  +      IV   +    I I I++NTL M +E++   E+ ++ L + N+VFT +F  
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 757 EMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSW 816
           EM+LK++   P+ Y +  +NIFDG+IV +S+ E+      GLSVLR+FRL+RV KL +  
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 817 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP-RW 875
           P L   + ++  ++  +    ++L + +FIF+++GM LFG  +        D  TLP R 
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF----ASERDGDTLPDRK 904

Query: 876 HMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALL 934
           + +    + + VF++L  E W + +++ M  +  +   + F+ +M  GN V+ NL +A+L
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAIL 963

Query: 935 LSSFSSD 941
           +  F ++
Sbjct: 964 VEGFQAE 970



 Score =  122 bits (307), Expect = 3e-27
 Identities = 97/377 (25%), Positives = 171/377 (45%), Gaps = 48/377 (12%)

Query: 118 RKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPD----------WTKNVEYTFTGIYTF 167
           R   ++ + +  F  + M  IL NCV + +  P +            +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 168 ESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVS--ALRTFRVLRALK 225
           E ++K++A G   +   +L D WN LDF +++   +   +DL NVS  A+RT RVLR L+
Sbjct: 131 EMVVKMVALGIFGKK-CYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 226 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDS 285
            I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LRN+C        
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249

Query: 286 AFETNTTSYFNGTMDSNGTFV------NVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGN 339
               +   Y+    +    F+      N   S  +     GD        G   P  CG 
Sbjct: 250 PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGD-------GGGGPP--CGL 300

Query: 340 GSDAGQCPEGYICV---------KAG-RNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLY 389
             +A        CV          AG  NP  G  +FD   +A++++F+++T + W ++ 
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 390 QLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQML 449
              + A      I+F+L+I +GSF+++NL L V+A  +          +E K+ E Q M 
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF----------SETKQRESQLMR 410

Query: 450 EQLKKQQEEAQAVAAAS 466
           EQ  +    A  +A+ S
Sbjct: 411 EQRVRFLSNASTLASFS 427



 Score =  119 bits (297), Expect = 4e-26
 Identities = 143/643 (22%), Positives = 270/643 (41%), Gaps = 99/643 (15%)

Query: 365  SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVA 424
            +FD+  WA +++F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 425  MAYEEQNQATLEEAEQK----------EAEFQQMLEQLKKQQEEAQAV-------AAASA 467
              ++ +  A   E+E            + +    L  L +  E  +++        AA+ 
Sbjct: 965  EGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATP 1024

Query: 468  ASRDFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSE 527
             S   S   GLGE L  +S  +  SS SA+       K         ++       P S 
Sbjct: 1025 MSLPKSTSTGLGEALGPASRRTS-SSGSAEPGAAHEMKSPPSARSSPHS-------PWSA 1076

Query: 528  SEDSVKRSSFLFSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDV 587
            +     R S   S+        +      +SLLS  G        S     S   RA   
Sbjct: 1077 ASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEES-----SEEERASPA 1131

Query: 588  GSENDFADDEHSTFEDSESRRDSLFVPHRHGERRNSNGTTTETEVRKRRLSSYQISMEML 647
            GS++          + S    D+L VP  H    +  G+ +E +    + +S +++  + 
Sbjct: 1132 GSDHRHRGSLEREAKSSFDLPDTLQVPGLH-RTASGRGSASEHQDCNGKSASGRLARALR 1190

Query: 648  EDSSGRQRAVSIASILTNTMEELEESRQKCPPCWYRFANVFLIWDCC---DAWL------ 698
             D               +  +E   S+ +    W R      +  CC   D+W       
Sbjct: 1191 PDDPPLDG--------DDADDEGNLSKGERVRAWIRAR----LPACCLERDSWSAYIFPP 1238

Query: 699  --KVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLTVGNLVFTGI 753
              + + L + I+     D  + + I LN + +AME  P  +  S+    LT+ N +FT +
Sbjct: 1239 QSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTAV 1297

Query: 754  FTAEMVLKIIAMDPYY----YFQEGWNIFDGIIVSLSLMELGLSNVEG--------LSVL 801
            F AEM +K++A+   +    Y +  WN+ DG++V +S++++ +S V          L VL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357

Query: 802  RSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYK 860
            R  R LR  ++      L ++++ + +S+  +GN+ ++      IF ++G+QLF GK + 
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF- 1416

Query: 861  ECVCKIND--------DCTLP--RW--HMNDF--FHSFLIVFRVLCGE--WIETMWDCME 904
              VC+  D        DC     RW  H  +F      L+   VL  +  W++ M+D ++
Sbjct: 1417 --VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLD 1474

Query: 905  VAG---------QTMCLIVFMLVMVIGNLVVLNLFLALLLSSF 938
              G             L+ F+  ++I    VLN+F+ +++ +F
Sbjct: 1475 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517



 Score =  110 bits (274), Expect = 2e-23
 Identities = 79/266 (29%), Positives = 131/266 (49%), Gaps = 24/266 (9%)

Query: 703  LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 762
            LV+ +    ++DL IT  I LN + MAMEHY   +     L + N +FT IF  E V K+
Sbjct: 1569 LVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKL 1628

Query: 763  IAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEG----------LSVLRSFRLLRVFKL 812
            +A     +FQ+ WN  D  IV LS+M + L  +E           + ++R  R+ RV KL
Sbjct: 1629 VAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKL 1688

Query: 813  AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTL 872
             K    +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +  C     C  
Sbjct: 1689 LKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG----DLECDETHPCEG 1744

Query: 873  PRWH--MNDFFHSFLIVFRVLCGE-W----IETMWDCMEVA---GQTMCLIVFMLVMVIG 922
               H    +F  +FL +FRV  G+ W     +T+ DC + +      +  I F+  ++  
Sbjct: 1745 LGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1804

Query: 923  NLVVLNLFLALLLSSFSSDNLAATDD 948
              V++N+ +A+L+      N  A ++
Sbjct: 1805 QFVLVNVVIAVLMKHLEESNKEAKEE 1830



 Score =  105 bits (262), Expect = 4e-22
 Identities = 87/393 (22%), Positives = 163/393 (41%), Gaps = 90/393 (22%)

Query: 109  YILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVE--------YT 160
            YI  P +  R +  +I+ H +F  +++  I  NC+ + +  P     + E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 161  FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVD---------LGN 211
            FT ++  E  +K++A G+C  +  +LR  WN LD  +++++ +   V          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 212  VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 272  NLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQ 331
                                                                 F+V  G+
Sbjct: 1414 K----------------------------------------------------FFVCQGE 1421

Query: 332  KDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQL 391
             D     N SD  +    ++  K      Y +   D    A +SLF L ++D W ++   
Sbjct: 1422 -DTRNITNKSDCAEASYRWVRHK------YNF---DNLGQALMSLFVLASKDGWVDIMYD 1471

Query: 392  TLRAAG----------KTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQ-ATLEEAEQ 440
             L A G             +++F+  + + +F+++N+ + VV   + +  Q    EEA +
Sbjct: 1472 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531

Query: 441  KEAEFQQMLEQLKKQQEEAQAVAAASAASRDFS 473
            +E +  + LE+ ++ +E+  A A       D+S
Sbjct: 1532 REEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYS 1564



 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 70/283 (24%), Positives = 132/283 (46%), Gaps = 41/283 (14%)

Query: 1143 WWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIF 1202
            W  +  T   IV+  +F   I+  IL+++ ++  E  Y EQ + +   LE ++ VFT +F
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLF 786

Query: 1203 ILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRP 1262
             LEMLLK + YG   Y  N +   D +IV +S+  +V       + G +  LRT R +R 
Sbjct: 787  ALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRV 841

Query: 1263 LRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGN 1322
            L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF          
Sbjct: 842  LKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA--------- 892

Query: 1323 MFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRD 1382
                 D + L D             + NFD++    + + Q+ T + W  ++Y  + S  
Sbjct: 893  --SERDGDTLPD-------------RKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST- 936

Query: 1383 VKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1425
                     + +  LYF+  + FG++   NL + ++++ F  +
Sbjct: 937  ---------SSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970



 Score = 91.3 bits (225), Expect = 8e-18
 Identities = 61/174 (35%), Positives = 96/174 (55%), Gaps = 19/174 (10%)

Query: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRKTIKTMLEYADKVFTYIF 1202
            R  C   V + WFE   + +ILL+   L      EDI  + ++  + +  + D +F + F
Sbjct: 71   RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF-F 128

Query: 1203 ILEMLLKWVA---YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYS---ELGAIKSLRT 1256
             +EM++K VA   +G + Y  + W  LDF IV       +A  L YS   +  +  ++RT
Sbjct: 129  AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAGMLEYSLDLQNVSFSAVRT 181

Query: 1257 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1310
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 182  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235



 Score = 85.5 bits (210), Expect = 5e-16
 Identities = 71/273 (26%), Positives = 129/273 (47%), Gaps = 35/273 (12%)

Query: 1474 VTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRH 1533
            V  + F   IMI I +N ++M +E  +Q + +T  L   N+VF  LF  E +LKL+    
Sbjct: 740  VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799

Query: 1534 Y-YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1592
            + Y    +NIFD V+V++S+      E++ +     ++ R  RL R+   L+L++    +
Sbjct: 800  FGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPAL 851

Query: 1593 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS----NFAYVKKEAGIDDMFNFETFGN 1648
            +  L  LM ++  +    +LL L +FI++I GM      FA  +    + D  NF++   
Sbjct: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLW 911

Query: 1649 SMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIII 1708
            +++ +FQI T   W+ +L                       G     S    +F++ +  
Sbjct: 912  AIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIALMTF 950

Query: 1709 SFLVVVNMYIAVILENFSVATEESAEPLSEDDF 1741
               V+ N+ +A+++E F  A  ++ +  SE DF
Sbjct: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 72.0 bits (175), Expect = 5e-12
 Identities = 35/104 (33%), Positives = 61/104 (58%), Gaps = 13/104 (12%)

Query: 1349 VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSF 1408
            +NFDN+G  ++A+ QV T +GW+DIMY  +D+           + Y ++YF++ II GSF
Sbjct: 335  INFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNFIYFILLIIVGSF 384

Query: 1409 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1452
            F +NL + VI   F++ K++   +   M E++ ++ +    L S
Sbjct: 385  FMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 47/155 (30%), Positives = 84/155 (54%), Gaps = 13/155 (8%)

Query: 123 KILVHSLFSMLIMCTILTNCVFMTLS---NPPDWTKNVEYT---FTGIYTFESLIKILAR 176
           KI+    F   IM  IL N + M +     P + T  +E +   FT ++  E L+K+L  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 177 GFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 234
           G     F ++++P+N  D  VIV+  V E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 47/175 (26%), Positives = 88/175 (50%), Gaps = 11/175 (6%)

Query: 708 VMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKII 763
           V +P+ +    + I+LN + + M    E      Q   +L   +      F  EMV+K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 764 AMDPY---YYFQEGWNIFDGIIVSLSLME--LGLSNVEGLSVLRSFRLLRVFKLAKSWPT 818
           A+  +    Y  + WN  D  IV   ++E  L L NV   S +R+ R+LR  +     P+
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLRPLRAINRVPS 196

Query: 819 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP 873
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+    +   C + ++ +LP
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN-RCFLPENFSLP 250



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 68/313 (21%), Positives = 130/313 (41%), Gaps = 87/313 (27%)

Query: 155  KNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSA 214
            K   Y FT I+  ES+ K++A GF      F +D WN LD ++++++ +   ++   V+A
Sbjct: 1610 KICNYIFTVIFVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNA 1665

Query: 215  -----------LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFAL 263
                       +R  R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA 
Sbjct: 1666 SLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAA 1725

Query: 264  IGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFN-WKDYIGDD 322
            +G++LF G+L  +C +  P +              +  + TF N  M+    ++   GD+
Sbjct: 1726 LGVELF-GDL--ECDETHPCEG-------------LGRHATFRNFGMAFLTLFRVSTGDN 1769

Query: 323  SHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQ 382
             +  + D  +D            C +   C     +P Y + SF                
Sbjct: 1770 WNGIMKDTLRD------------CDQESTCYNTVISPIY-FVSF---------------- 1800

Query: 383  DYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKE 442
                                     +    F LVN+++AV+    EE N+   EEAE  E
Sbjct: 1801 -------------------------VLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE-LE 1834

Query: 443  AEFQQMLEQLKKQ 455
            AE +  ++ L  Q
Sbjct: 1835 AELELEMKTLSPQ 1847



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 46/159 (28%), Positives = 71/159 (44%), Gaps = 15/159 (9%)

Query: 1479 FDISIMILICLNMVTMMV----ETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSL--- 1531
            F+   M++I LN VT+ +    E          +L   +      F  E V+K+V+L   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1532 -RHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1590
             +  Y    WN  DF +VI  ++   L        +    F  +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAINRVP 195

Query: 1591 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1629
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 33.1 bits (74), Expect = 2.7
 Identities = 16/59 (27%), Positives = 38/59 (64%), Gaps = 2/59 (3%)

Query: 882 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 939
           ++++ +F+V+  E W++ M+  M+ A      I F+L++++G+  ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 399



 Score = 32.7 bits (73), Expect = 3.6
 Identities = 23/116 (19%), Positives = 46/116 (39%), Gaps = 25/116 (21%)

Query: 1627 NFAYVKKEAGIDDMF----NFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTI 1682
            N  Y    AG  + F    NF+  G + I +FQ+ T  GW  ++  ++++          
Sbjct: 317  NQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------- 366

Query: 1683 HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1738
                       +      +F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 367  -----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411


>gi|38505276 voltage-dependent calcium channel alpha 1G subunit
            isoform 5 [Homo sapiens]
          Length = 2321

 Score =  333 bits (853), Expect = 1e-90
 Identities = 199/609 (32%), Positives = 338/609 (55%), Gaps = 43/609 (7%)

Query: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1206
            R  C+ I+ H  F+  ++ +I L+   +A E   I+     +  L  ++ +FT +F+ EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325

Query: 1207 LLKWVAYGF----QTYFTNAWCWLDFLIVDVSLVSLVANAL---GYSELGAIKSLRTLRA 1259
             +K VA G+    Q Y  ++W  LD L+V +S++ ++ + +   G   LG ++ LR LR 
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385

Query: 1260 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1319
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1445

Query: 1320 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1379
            T N      + N SDC       RW   K NFDN+G   ++L  +A+  GW+DIMY  +D
Sbjct: 1446 TRN------ITNKSDCAEASY--RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLD 1497

Query: 1380 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1439
            +  V  QP+   N +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++     E
Sbjct: 1498 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRRE 1556

Query: 1440 QKKYYNAMKKLGSKKPQ------KPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVT 1493
            +K+     KK  SK+ Q      KP     ++F+ +V    T    D+ I  +I LN+VT
Sbjct: 1557 EKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVT 1616

Query: 1494 MMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLR-HYYFTIGWNIFDFVVVILSI 1552
            M +E   Q + +   L   N +F V+F  E V KLV+     +F   WN  D  +V+LSI
Sbjct: 1617 MAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSI 1676

Query: 1553 VGMFL--AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIG 1610
            +G+ L   E+     ++PT+ R++R+ RI R+L+L+K A G+R LL  +M +LP + N+G
Sbjct: 1677 MGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLG 1736

Query: 1611 LLLFLVMFIYAIFGMSNFAYVKKE-----AGIDDMFNFETFGNSMICLFQITTSAGWDGL 1665
            LL  L+ FI+A  G+  F  ++ +      G+     F  FG + + LF+++T   W+G+
Sbjct: 1737 LLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGI 1796

Query: 1666 LAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1725
            +   L     DCD ++          C N  +   +FVS+++ +  V+VN+ IAV++++ 
Sbjct: 1797 MKDTLR----DCDQES---------TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHL 1843

Query: 1726 SVATEESAE 1734
              + +E+ E
Sbjct: 1844 EESNKEAKE 1852



 Score =  145 bits (365), Expect = 5e-34
 Identities = 81/266 (30%), Positives = 150/266 (56%), Gaps = 8/266 (3%)

Query: 697 WLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTA 756
           W  +      IV   +    I I I++NTL M +E++   E+ ++ L + N+VFT +F  
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 757 EMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSW 816
           EM+LK++   P+ Y +  +NIFDG+IV +S+ E+      GLSVLR+FRL+RV KL +  
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 817 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP-RW 875
           P L   + ++  ++  +    ++L + +FIF+++GM LFG  +        D  TLP R 
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF----ASERDGDTLPDRK 904

Query: 876 HMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALL 934
           + +    + + VF++L  E W + +++ M  +  +   + F+ +M  GN V+ NL +A+L
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAIL 963

Query: 935 LSSFSSDNLAATDD-DNEMNNLQIAV 959
           +  F ++ ++  +D   +++ +Q+ V
Sbjct: 964 VEGFQAEEISKREDASGQLSCIQLPV 989



 Score =  122 bits (307), Expect = 3e-27
 Identities = 97/377 (25%), Positives = 171/377 (45%), Gaps = 48/377 (12%)

Query: 118 RKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPD----------WTKNVEYTFTGIYTF 167
           R   ++ + +  F  + M  IL NCV + +  P +            +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 168 ESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVS--ALRTFRVLRALK 225
           E ++K++A G   +   +L D WN LDF +++   +   +DL NVS  A+RT RVLR L+
Sbjct: 131 EMVVKMVALGIFGKK-CYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 226 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDS 285
            I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LRN+C        
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249

Query: 286 AFETNTTSYFNGTMDSNGTFV------NVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGN 339
               +   Y+    +    F+      N   S  +     GD        G   P  CG 
Sbjct: 250 PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGD-------GGGGPP--CGL 300

Query: 340 GSDAGQCPEGYICV---------KAG-RNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLY 389
             +A        CV          AG  NP  G  +FD   +A++++F+++T + W ++ 
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 390 QLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQML 449
              + A      I+F+L+I +GSF+++NL L V+A  +          +E K+ E Q M 
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF----------SETKQRESQLMR 410

Query: 450 EQLKKQQEEAQAVAAAS 466
           EQ  +    A  +A+ S
Sbjct: 411 EQRVRFLSNASTLASFS 427



 Score =  112 bits (281), Expect = 3e-24
 Identities = 151/666 (22%), Positives = 284/666 (42%), Gaps = 122/666 (18%)

Query: 365  SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVA 424
            +FD+  WA +++F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 425  MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGELLES 484
              ++ +     E +++++A  Q    QL    +   A  + S        + G G+  + 
Sbjct: 965  EGFQAE-----EISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKC 1019

Query: 485  SSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESED-------SVKRSSF 537
                  L+  S  E    RK       L  +      S PKS S         + +R+S 
Sbjct: 1020 ------LALVSLGEHPELRKSLLPP--LIIHTAATPMSLPKSTSTGLGEALGPASRRTSS 1071

Query: 538  LFSMDGNRLTSDKK----FCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDV------ 587
              S +       K       SPH    +   S ++ RR+S+ S+    GRA  +      
Sbjct: 1072 SGSAEPGAAHEMKSPPSARSSPHSPWSA--ASSWTSRRSSRNSL----GRAPSLKRRSPS 1125

Query: 588  --------GSENDFADDEHSTFEDSESRRDSLFVPHRHG-----ERRNSNGTTTETEVRK 634
                    G   +  D+E S+ E+  S   S    HRH      E ++S       +V  
Sbjct: 1126 GERRSLLSGEGQESQDEEESSEEERASPAGS---DHRHRGSLEREAKSSFDLPDTLQVPG 1182

Query: 635  -RRLSSYQISMEMLEDSSGRQRAVSIASILT---------NTMEELEESRQKCPPCWYRF 684
              R +S + S    +D +G+  +  +A  L          +  +E   S+ +    W R 
Sbjct: 1183 LHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRA 1242

Query: 685  ANVFLIWDCC---DAWL--------KVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHY 733
                 +  CC   D+W         + + L + I+     D  + + I LN + +AME  
Sbjct: 1243 R----LPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER- 1297

Query: 734  PMTEQFSS---VLTVGNLVFTGIFTAEMVLKIIAMDPYY----YFQEGWNIFDGIIVSLS 786
            P  +  S+    LT+ N +FT +F AEM +K++A+   +    Y +  WN+ DG++V +S
Sbjct: 1298 PKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLIS 1357

Query: 787  LMELGLSNVEG--------LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTL 838
            ++++ +S V          L VLR  R LR  ++      L ++++ + +S+  +GN+ +
Sbjct: 1358 VIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVV 1417

Query: 839  VLAIIVFIFAVVGMQLF-GKSYKECVCKIND--------DCTLP--RW--HMNDF--FHS 883
            +      IF ++G+QLF GK +   VC+  D        DC     RW  H  +F     
Sbjct: 1418 ICCAFFIIFGILGVQLFKGKFF---VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474

Query: 884  FLIVFRVLCGE--WIETMWDCMEVAG---------QTMCLIVFMLVMVIGNLVVLNLFLA 932
             L+   VL  +  W++ M+D ++  G             L+ F+  ++I    VLN+F+ 
Sbjct: 1475 ALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVG 1534

Query: 933  LLLSSF 938
            +++ +F
Sbjct: 1535 VVVENF 1540



 Score =  110 bits (274), Expect = 2e-23
 Identities = 79/266 (29%), Positives = 131/266 (49%), Gaps = 24/266 (9%)

Query: 703  LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 762
            LV+ +    ++DL IT  I LN + MAMEHY   +     L + N +FT IF  E V K+
Sbjct: 1592 LVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKL 1651

Query: 763  IAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEG----------LSVLRSFRLLRVFKL 812
            +A     +FQ+ WN  D  IV LS+M + L  +E           + ++R  R+ RV KL
Sbjct: 1652 VAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKL 1711

Query: 813  AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTL 872
             K    +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +  C     C  
Sbjct: 1712 LKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG----DLECDETHPCEG 1767

Query: 873  PRWH--MNDFFHSFLIVFRVLCGE-W----IETMWDCMEVA---GQTMCLIVFMLVMVIG 922
               H    +F  +FL +FRV  G+ W     +T+ DC + +      +  I F+  ++  
Sbjct: 1768 LGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1827

Query: 923  NLVVLNLFLALLLSSFSSDNLAATDD 948
              V++N+ +A+L+      N  A ++
Sbjct: 1828 QFVLVNVVIAVLMKHLEESNKEAKEE 1853



 Score =  105 bits (262), Expect = 4e-22
 Identities = 87/393 (22%), Positives = 163/393 (41%), Gaps = 90/393 (22%)

Query: 109  YILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVE--------YT 160
            YI  P +  R +  +I+ H +F  +++  I  NC+ + +  P     + E        Y 
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316

Query: 161  FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVD---------LGN 211
            FT ++  E  +K++A G+C  +  +LR  WN LD  +++++ +   V          LG 
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376

Query: 212  VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436

Query: 272  NLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQ 331
                                                                 F+V  G+
Sbjct: 1437 K----------------------------------------------------FFVCQGE 1444

Query: 332  KDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQL 391
             D     N SD  +    ++  K      Y +   D    A +SLF L ++D W ++   
Sbjct: 1445 -DTRNITNKSDCAEASYRWVRHK------YNF---DNLGQALMSLFVLASKDGWVDIMYD 1494

Query: 392  TLRAAG----------KTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQ-ATLEEAEQ 440
             L A G             +++F+  + + +F+++N+ + VV   + +  Q    EEA +
Sbjct: 1495 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1554

Query: 441  KEAEFQQMLEQLKKQQEEAQAVAAASAASRDFS 473
            +E +  + LE+ ++ +E+  A A       D+S
Sbjct: 1555 REEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYS 1587



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 70/284 (24%), Positives = 133/284 (46%), Gaps = 41/284 (14%)

Query: 1143 WWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIF 1202
            W  +  T   IV+  +F   I+  IL+++ ++  E  Y EQ + +   LE ++ VFT +F
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLF 786

Query: 1203 ILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRP 1262
             LEMLLK + YG   Y  N +   D +IV +S+  +V       + G +  LRT R +R 
Sbjct: 787  ALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRV 841

Query: 1263 LRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGN 1322
            L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF          
Sbjct: 842  LKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA--------- 892

Query: 1323 MFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRD 1382
                 D + L D             + NFD++    + + Q+ T + W  ++Y  + S  
Sbjct: 893  --SERDGDTLPD-------------RKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST- 936

Query: 1383 VKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1426
                     + +  LYF+  + FG++   NL + ++++ F  ++
Sbjct: 937  ---------SSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971



 Score = 91.3 bits (225), Expect = 8e-18
 Identities = 61/174 (35%), Positives = 96/174 (55%), Gaps = 19/174 (10%)

Query: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRKTIKTMLEYADKVFTYIF 1202
            R  C   V + WFE   + +ILL+   L      EDI  + ++  + +  + D +F + F
Sbjct: 71   RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF-F 128

Query: 1203 ILEMLLKWVA---YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYS---ELGAIKSLRT 1256
             +EM++K VA   +G + Y  + W  LDF IV       +A  L YS   +  +  ++RT
Sbjct: 129  AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAGMLEYSLDLQNVSFSAVRT 181

Query: 1257 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1310
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 182  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 68/269 (25%), Positives = 123/269 (45%), Gaps = 34/269 (12%)

Query: 1474 VTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRH 1533
            V  + F   IMI I +N ++M +E  +Q + +T  L   N+VF  LF  E +LKL+    
Sbjct: 740  VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799

Query: 1534 Y-YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1592
            + Y    +NIFD V+V++S+      E++ +     ++ R  RL    R+L+L++    +
Sbjct: 800  FGYIKNPYNIFDGVIVVISV-----WEIVGQQGGGLSVLRTFRLM---RVLKLVRFLPAL 851

Query: 1593 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM----SNFAYVKKEAGIDDMFNFETFGN 1648
            +  L  LM ++  +    +LL L +FI++I GM      FA  +    + D  NF++   
Sbjct: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLW 911

Query: 1649 SMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIII 1708
            +++ +FQI T   W+ +L                       G     S    +F++ +  
Sbjct: 912  AIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIALMTF 950

Query: 1709 SFLVVVNMYIAVILENFSVATEESAEPLS 1737
               V+ N+ +A+++E F        E  S
Sbjct: 951  GNYVLFNLLVAILVEGFQAEEISKREDAS 979



 Score = 72.0 bits (175), Expect = 5e-12
 Identities = 35/104 (33%), Positives = 61/104 (58%), Gaps = 13/104 (12%)

Query: 1349 VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSF 1408
            +NFDN+G  ++A+ QV T +GW+DIMY  +D+           + Y ++YF++ II GSF
Sbjct: 335  INFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNFIYFILLIIVGSF 384

Query: 1409 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1452
            F +NL + VI   F++ K++   +   M E++ ++ +    L S
Sbjct: 385  FMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 47/155 (30%), Positives = 84/155 (54%), Gaps = 13/155 (8%)

Query: 123 KILVHSLFSMLIMCTILTNCVFMTLS---NPPDWTKNVEYT---FTGIYTFESLIKILAR 176
           KI+    F   IM  IL N + M +     P + T  +E +   FT ++  E L+K+L  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 177 GFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 234
           G     F ++++P+N  D  VIV+  V E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 47/175 (26%), Positives = 88/175 (50%), Gaps = 11/175 (6%)

Query: 708 VMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKII 763
           V +P+ +    + I+LN + + M    E      Q   +L   +      F  EMV+K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 764 AMDPY---YYFQEGWNIFDGIIVSLSLME--LGLSNVEGLSVLRSFRLLRVFKLAKSWPT 818
           A+  +    Y  + WN  D  IV   ++E  L L NV   S +R+ R+LR  +     P+
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLRPLRAINRVPS 196

Query: 819 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP 873
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+    +   C + ++ +LP
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN-RCFLPENFSLP 250



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 68/313 (21%), Positives = 130/313 (41%), Gaps = 87/313 (27%)

Query: 155  KNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSA 214
            K   Y FT I+  ES+ K++A GF      F +D WN LD ++++++ +   ++   V+A
Sbjct: 1633 KICNYIFTVIFVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNA 1688

Query: 215  -----------LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFAL 263
                       +R  R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA 
Sbjct: 1689 SLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAA 1748

Query: 264  IGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFN-WKDYIGDD 322
            +G++LF G+L  +C +  P +              +  + TF N  M+    ++   GD+
Sbjct: 1749 LGVELF-GDL--ECDETHPCEG-------------LGRHATFRNFGMAFLTLFRVSTGDN 1792

Query: 323  SHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQ 382
             +  + D  +D            C +   C     +P Y + SF                
Sbjct: 1793 WNGIMKDTLRD------------CDQESTCYNTVISPIY-FVSF---------------- 1823

Query: 383  DYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKE 442
                                     +    F LVN+++AV+    EE N+   EEAE  E
Sbjct: 1824 -------------------------VLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE-LE 1857

Query: 443  AEFQQMLEQLKKQ 455
            AE +  ++ L  Q
Sbjct: 1858 AELELEMKTLSPQ 1870



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 46/159 (28%), Positives = 71/159 (44%), Gaps = 15/159 (9%)

Query: 1479 FDISIMILICLNMVTMMV----ETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSL--- 1531
            F+   M++I LN VT+ +    E          +L   +      F  E V+K+V+L   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1532 -RHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1590
             +  Y    WN  DF +VI  ++   L        +    F  +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAINRVP 195

Query: 1591 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1629
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 33.1 bits (74), Expect = 2.7
 Identities = 16/59 (27%), Positives = 38/59 (64%), Gaps = 2/59 (3%)

Query: 882 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 939
           ++++ +F+V+  E W++ M+  M+ A      I F+L++++G+  ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 399



 Score = 32.7 bits (73), Expect = 3.6
 Identities = 23/116 (19%), Positives = 46/116 (39%), Gaps = 25/116 (21%)

Query: 1627 NFAYVKKEAGIDDMF----NFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTI 1682
            N  Y    AG  + F    NF+  G + I +FQ+ T  GW  ++  ++++          
Sbjct: 317  NQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------- 366

Query: 1683 HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1738
                       +      +F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 367  -----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411


>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
            isoform 7 [Homo sapiens]
          Length = 2298

 Score =  333 bits (853), Expect = 1e-90
 Identities = 199/609 (32%), Positives = 338/609 (55%), Gaps = 43/609 (7%)

Query: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1206
            R  C+ I+ H  F+  ++ +I L+   +A E   I+     +  L  ++ +FT +F+ EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302

Query: 1207 LLKWVAYGF----QTYFTNAWCWLDFLIVDVSLVSLVANAL---GYSELGAIKSLRTLRA 1259
             +K VA G+    Q Y  ++W  LD L+V +S++ ++ + +   G   LG ++ LR LR 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 1260 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1319
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1422

Query: 1320 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1379
            T N      + N SDC       RW   K NFDN+G   ++L  +A+  GW+DIMY  +D
Sbjct: 1423 TRN------ITNKSDCAEASY--RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLD 1474

Query: 1380 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1439
            +  V  QP+   N +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++     E
Sbjct: 1475 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRRE 1533

Query: 1440 QKKYYNAMKKLGSKKPQ------KPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVT 1493
            +K+     KK  SK+ Q      KP     ++F+ +V    T    D+ I  +I LN+VT
Sbjct: 1534 EKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVT 1593

Query: 1494 MMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLR-HYYFTIGWNIFDFVVVILSI 1552
            M +E   Q + +   L   N +F V+F  E V KLV+     +F   WN  D  +V+LSI
Sbjct: 1594 MAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSI 1653

Query: 1553 VGMFL--AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIG 1610
            +G+ L   E+     ++PT+ R++R+ RI R+L+L+K A G+R LL  +M +LP + N+G
Sbjct: 1654 MGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLG 1713

Query: 1611 LLLFLVMFIYAIFGMSNFAYVKKE-----AGIDDMFNFETFGNSMICLFQITTSAGWDGL 1665
            LL  L+ FI+A  G+  F  ++ +      G+     F  FG + + LF+++T   W+G+
Sbjct: 1714 LLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGI 1773

Query: 1666 LAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1725
            +   L     DCD ++          C N  +   +FVS+++ +  V+VN+ IAV++++ 
Sbjct: 1774 MKDTLR----DCDQES---------TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHL 1820

Query: 1726 SVATEESAE 1734
              + +E+ E
Sbjct: 1821 EESNKEAKE 1829



 Score =  140 bits (354), Expect = 9e-33
 Identities = 78/247 (31%), Positives = 139/247 (56%), Gaps = 7/247 (2%)

Query: 697 WLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTA 756
           W  +      IV   +    I I I++NTL M +E++   E+ ++ L + N+VFT +F  
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 757 EMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSW 816
           EM+LK++   P+ Y +  +NIFDG+IV +S+ E+      GLSVLR+FRL+RV KL +  
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 817 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP-RW 875
           P L   + ++  ++  +    ++L + +FIF+++GM LFG  +        D  TLP R 
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF----ASERDGDTLPDRK 904

Query: 876 HMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALL 934
           + +    + + VF++L  E W + +++ M  +  +   + F+ +M  GN V+ NL +A+L
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAIL 963

Query: 935 LSSFSSD 941
           +  F ++
Sbjct: 964 VEGFQAE 970



 Score =  122 bits (307), Expect = 3e-27
 Identities = 97/377 (25%), Positives = 171/377 (45%), Gaps = 48/377 (12%)

Query: 118 RKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPD----------WTKNVEYTFTGIYTF 167
           R   ++ + +  F  + M  IL NCV + +  P +            +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 168 ESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVS--ALRTFRVLRALK 225
           E ++K++A G   +   +L D WN LDF +++   +   +DL NVS  A+RT RVLR L+
Sbjct: 131 EMVVKMVALGIFGKK-CYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 226 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDS 285
            I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LRN+C        
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249

Query: 286 AFETNTTSYFNGTMDSNGTFV------NVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGN 339
               +   Y+    +    F+      N   S  +     GD        G   P  CG 
Sbjct: 250 PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGD-------GGGGPP--CGL 300

Query: 340 GSDAGQCPEGYICV---------KAG-RNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLY 389
             +A        CV          AG  NP  G  +FD   +A++++F+++T + W ++ 
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 390 QLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQML 449
              + A      I+F+L+I +GSF+++NL L V+A  +          +E K+ E Q M 
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF----------SETKQRESQLMR 410

Query: 450 EQLKKQQEEAQAVAAAS 466
           EQ  +    A  +A+ S
Sbjct: 411 EQRVRFLSNASTLASFS 427



 Score =  119 bits (297), Expect = 4e-26
 Identities = 143/643 (22%), Positives = 270/643 (41%), Gaps = 99/643 (15%)

Query: 365  SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVA 424
            +FD+  WA +++F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 425  MAYEEQNQATLEEAEQK----------EAEFQQMLEQLKKQQEEAQAV-------AAASA 467
              ++ +  A   E+E            + +    L  L +  E  +++        AA+ 
Sbjct: 965  EGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATP 1024

Query: 468  ASRDFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSE 527
             S   S   GLGE L  +S  +  SS SA+       K         ++       P S 
Sbjct: 1025 MSLPKSTSTGLGEALGPASRRTS-SSGSAEPGAAHEMKSPPSARSSPHS-------PWSA 1076

Query: 528  SEDSVKRSSFLFSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDV 587
            +     R S   S+        +      +SLLS  G        S     S   RA   
Sbjct: 1077 ASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEES-----SEEERASPA 1131

Query: 588  GSENDFADDEHSTFEDSESRRDSLFVPHRHGERRNSNGTTTETEVRKRRLSSYQISMEML 647
            GS++          + S    D+L VP  H    +  G+ +E +    + +S +++  + 
Sbjct: 1132 GSDHRHRGSLEREAKSSFDLPDTLQVPGLH-RTASGRGSASEHQDCNGKSASGRLARALR 1190

Query: 648  EDSSGRQRAVSIASILTNTMEELEESRQKCPPCWYRFANVFLIWDCC---DAWL------ 698
             D               +  +E   S+ +    W R      +  CC   D+W       
Sbjct: 1191 PDDPPLDG--------DDADDEGNLSKGERVRAWIRAR----LPACCLERDSWSAYIFPP 1238

Query: 699  --KVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLTVGNLVFTGI 753
              + + L + I+     D  + + I LN + +AME  P  +  S+    LT+ N +FT +
Sbjct: 1239 QSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTAV 1297

Query: 754  FTAEMVLKIIAMDPYY----YFQEGWNIFDGIIVSLSLMELGLSNVEG--------LSVL 801
            F AEM +K++A+   +    Y +  WN+ DG++V +S++++ +S V          L VL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357

Query: 802  RSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYK 860
            R  R LR  ++      L ++++ + +S+  +GN+ ++      IF ++G+QLF GK + 
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF- 1416

Query: 861  ECVCKIND--------DCTLP--RW--HMNDF--FHSFLIVFRVLCGE--WIETMWDCME 904
              VC+  D        DC     RW  H  +F      L+   VL  +  W++ M+D ++
Sbjct: 1417 --VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLD 1474

Query: 905  VAG---------QTMCLIVFMLVMVIGNLVVLNLFLALLLSSF 938
              G             L+ F+  ++I    VLN+F+ +++ +F
Sbjct: 1475 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517



 Score =  110 bits (274), Expect = 2e-23
 Identities = 79/266 (29%), Positives = 131/266 (49%), Gaps = 24/266 (9%)

Query: 703  LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 762
            LV+ +    ++DL IT  I LN + MAMEHY   +     L + N +FT IF  E V K+
Sbjct: 1569 LVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKL 1628

Query: 763  IAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEG----------LSVLRSFRLLRVFKL 812
            +A     +FQ+ WN  D  IV LS+M + L  +E           + ++R  R+ RV KL
Sbjct: 1629 VAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKL 1688

Query: 813  AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTL 872
             K    +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +  C     C  
Sbjct: 1689 LKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG----DLECDETHPCEG 1744

Query: 873  PRWH--MNDFFHSFLIVFRVLCGE-W----IETMWDCMEVA---GQTMCLIVFMLVMVIG 922
               H    +F  +FL +FRV  G+ W     +T+ DC + +      +  I F+  ++  
Sbjct: 1745 LGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1804

Query: 923  NLVVLNLFLALLLSSFSSDNLAATDD 948
              V++N+ +A+L+      N  A ++
Sbjct: 1805 QFVLVNVVIAVLMKHLEESNKEAKEE 1830



 Score =  105 bits (262), Expect = 4e-22
 Identities = 87/393 (22%), Positives = 163/393 (41%), Gaps = 90/393 (22%)

Query: 109  YILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVE--------YT 160
            YI  P +  R +  +I+ H +F  +++  I  NC+ + +  P     + E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 161  FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVD---------LGN 211
            FT ++  E  +K++A G+C  +  +LR  WN LD  +++++ +   V          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 212  VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 272  NLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQ 331
                                                                 F+V  G+
Sbjct: 1414 K----------------------------------------------------FFVCQGE 1421

Query: 332  KDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQL 391
             D     N SD  +    ++  K      Y +   D    A +SLF L ++D W ++   
Sbjct: 1422 -DTRNITNKSDCAEASYRWVRHK------YNF---DNLGQALMSLFVLASKDGWVDIMYD 1471

Query: 392  TLRAAG----------KTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQ-ATLEEAEQ 440
             L A G             +++F+  + + +F+++N+ + VV   + +  Q    EEA +
Sbjct: 1472 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531

Query: 441  KEAEFQQMLEQLKKQQEEAQAVAAASAASRDFS 473
            +E +  + LE+ ++ +E+  A A       D+S
Sbjct: 1532 REEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYS 1564



 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 70/283 (24%), Positives = 132/283 (46%), Gaps = 41/283 (14%)

Query: 1143 WWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIF 1202
            W  +  T   IV+  +F   I+  IL+++ ++  E  Y EQ + +   LE ++ VFT +F
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLF 786

Query: 1203 ILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRP 1262
             LEMLLK + YG   Y  N +   D +IV +S+  +V       + G +  LRT R +R 
Sbjct: 787  ALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRV 841

Query: 1263 LRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGN 1322
            L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF          
Sbjct: 842  LKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA--------- 892

Query: 1323 MFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRD 1382
                 D + L D             + NFD++    + + Q+ T + W  ++Y  + S  
Sbjct: 893  --SERDGDTLPD-------------RKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST- 936

Query: 1383 VKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1425
                     + +  LYF+  + FG++   NL + ++++ F  +
Sbjct: 937  ---------SSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970



 Score = 91.3 bits (225), Expect = 8e-18
 Identities = 61/174 (35%), Positives = 96/174 (55%), Gaps = 19/174 (10%)

Query: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRKTIKTMLEYADKVFTYIF 1202
            R  C   V + WFE   + +ILL+   L      EDI  + ++  + +  + D +F + F
Sbjct: 71   RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF-F 128

Query: 1203 ILEMLLKWVA---YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYS---ELGAIKSLRT 1256
             +EM++K VA   +G + Y  + W  LDF IV       +A  L YS   +  +  ++RT
Sbjct: 129  AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAGMLEYSLDLQNVSFSAVRT 181

Query: 1257 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1310
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 182  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235



 Score = 85.5 bits (210), Expect = 5e-16
 Identities = 71/273 (26%), Positives = 129/273 (47%), Gaps = 35/273 (12%)

Query: 1474 VTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRH 1533
            V  + F   IMI I +N ++M +E  +Q + +T  L   N+VF  LF  E +LKL+    
Sbjct: 740  VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799

Query: 1534 Y-YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1592
            + Y    +NIFD V+V++S+      E++ +     ++ R  RL R+   L+L++    +
Sbjct: 800  FGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPAL 851

Query: 1593 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS----NFAYVKKEAGIDDMFNFETFGN 1648
            +  L  LM ++  +    +LL L +FI++I GM      FA  +    + D  NF++   
Sbjct: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLW 911

Query: 1649 SMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIII 1708
            +++ +FQI T   W+ +L                       G     S    +F++ +  
Sbjct: 912  AIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIALMTF 950

Query: 1709 SFLVVVNMYIAVILENFSVATEESAEPLSEDDF 1741
               V+ N+ +A+++E F  A  ++ +  SE DF
Sbjct: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 72.0 bits (175), Expect = 5e-12
 Identities = 35/104 (33%), Positives = 61/104 (58%), Gaps = 13/104 (12%)

Query: 1349 VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSF 1408
            +NFDN+G  ++A+ QV T +GW+DIMY  +D+           + Y ++YF++ II GSF
Sbjct: 335  INFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNFIYFILLIIVGSF 384

Query: 1409 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1452
            F +NL + VI   F++ K++   +   M E++ ++ +    L S
Sbjct: 385  FMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 47/155 (30%), Positives = 84/155 (54%), Gaps = 13/155 (8%)

Query: 123 KILVHSLFSMLIMCTILTNCVFMTLS---NPPDWTKNVEYT---FTGIYTFESLIKILAR 176
           KI+    F   IM  IL N + M +     P + T  +E +   FT ++  E L+K+L  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 177 GFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 234
           G     F ++++P+N  D  VIV+  V E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 47/175 (26%), Positives = 88/175 (50%), Gaps = 11/175 (6%)

Query: 708 VMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKII 763
           V +P+ +    + I+LN + + M    E      Q   +L   +      F  EMV+K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 764 AMDPY---YYFQEGWNIFDGIIVSLSLME--LGLSNVEGLSVLRSFRLLRVFKLAKSWPT 818
           A+  +    Y  + WN  D  IV   ++E  L L NV   S +R+ R+LR  +     P+
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLRPLRAINRVPS 196

Query: 819 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP 873
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+    +   C + ++ +LP
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN-RCFLPENFSLP 250



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 68/313 (21%), Positives = 130/313 (41%), Gaps = 87/313 (27%)

Query: 155  KNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSA 214
            K   Y FT I+  ES+ K++A GF      F +D WN LD ++++++ +   ++   V+A
Sbjct: 1610 KICNYIFTVIFVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNA 1665

Query: 215  -----------LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFAL 263
                       +R  R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA 
Sbjct: 1666 SLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAA 1725

Query: 264  IGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFN-WKDYIGDD 322
            +G++LF G+L  +C +  P +              +  + TF N  M+    ++   GD+
Sbjct: 1726 LGVELF-GDL--ECDETHPCEG-------------LGRHATFRNFGMAFLTLFRVSTGDN 1769

Query: 323  SHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQ 382
             +  + D  +D            C +   C     +P Y + SF                
Sbjct: 1770 WNGIMKDTLRD------------CDQESTCYNTVISPIY-FVSF---------------- 1800

Query: 383  DYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKE 442
                                     +    F LVN+++AV+    EE N+   EEAE  E
Sbjct: 1801 -------------------------VLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE-LE 1834

Query: 443  AEFQQMLEQLKKQ 455
            AE +  ++ L  Q
Sbjct: 1835 AELELEMKTLSPQ 1847



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 46/159 (28%), Positives = 71/159 (44%), Gaps = 15/159 (9%)

Query: 1479 FDISIMILICLNMVTMMV----ETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSL--- 1531
            F+   M++I LN VT+ +    E          +L   +      F  E V+K+V+L   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1532 -RHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1590
             +  Y    WN  DF +VI  ++   L        +    F  +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAINRVP 195

Query: 1591 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1629
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 33.1 bits (74), Expect = 2.7
 Identities = 16/59 (27%), Positives = 38/59 (64%), Gaps = 2/59 (3%)

Query: 882 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 939
           ++++ +F+V+  E W++ M+  M+ A      I F+L++++G+  ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 399



 Score = 32.7 bits (73), Expect = 3.6
 Identities = 23/116 (19%), Positives = 46/116 (39%), Gaps = 25/116 (21%)

Query: 1627 NFAYVKKEAGIDDMF----NFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTI 1682
            N  Y    AG  + F    NF+  G + I +FQ+ T  GW  ++  ++++          
Sbjct: 317  NQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------- 366

Query: 1683 HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1738
                       +      +F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 367  -----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411


>gi|38505272 voltage-dependent calcium channel alpha 1G subunit
            isoform 9 [Homo sapiens]
          Length = 2273

 Score =  333 bits (853), Expect = 1e-90
 Identities = 199/609 (32%), Positives = 338/609 (55%), Gaps = 43/609 (7%)

Query: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1206
            R  C+ I+ H  F+  ++ +I L+   +A E   I+     +  L  ++ +FT +F+ EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325

Query: 1207 LLKWVAYGF----QTYFTNAWCWLDFLIVDVSLVSLVANAL---GYSELGAIKSLRTLRA 1259
             +K VA G+    Q Y  ++W  LD L+V +S++ ++ + +   G   LG ++ LR LR 
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385

Query: 1260 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1319
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1445

Query: 1320 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1379
            T N      + N SDC       RW   K NFDN+G   ++L  +A+  GW+DIMY  +D
Sbjct: 1446 TRN------ITNKSDCAEASY--RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLD 1497

Query: 1380 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1439
            +  V  QP+   N +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++     E
Sbjct: 1498 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRRE 1556

Query: 1440 QKKYYNAMKKLGSKKPQ------KPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVT 1493
            +K+     KK  SK+ Q      KP     ++F+ +V    T    D+ I  +I LN+VT
Sbjct: 1557 EKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVT 1616

Query: 1494 MMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLR-HYYFTIGWNIFDFVVVILSI 1552
            M +E   Q + +   L   N +F V+F  E V KLV+     +F   WN  D  +V+LSI
Sbjct: 1617 MAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSI 1676

Query: 1553 VGMFL--AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIG 1610
            +G+ L   E+     ++PT+ R++R+ RI R+L+L+K A G+R LL  +M +LP + N+G
Sbjct: 1677 MGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLG 1736

Query: 1611 LLLFLVMFIYAIFGMSNFAYVKKE-----AGIDDMFNFETFGNSMICLFQITTSAGWDGL 1665
            LL  L+ FI+A  G+  F  ++ +      G+     F  FG + + LF+++T   W+G+
Sbjct: 1737 LLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGI 1796

Query: 1666 LAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1725
            +   L     DCD ++          C N  +   +FVS+++ +  V+VN+ IAV++++ 
Sbjct: 1797 MKDTLR----DCDQES---------TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHL 1843

Query: 1726 SVATEESAE 1734
              + +E+ E
Sbjct: 1844 EESNKEAKE 1852



 Score =  145 bits (365), Expect = 5e-34
 Identities = 81/266 (30%), Positives = 150/266 (56%), Gaps = 8/266 (3%)

Query: 697 WLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTA 756
           W  +      IV   +    I I I++NTL M +E++   E+ ++ L + N+VFT +F  
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 757 EMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSW 816
           EM+LK++   P+ Y +  +NIFDG+IV +S+ E+      GLSVLR+FRL+RV KL +  
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 817 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP-RW 875
           P L   + ++  ++  +    ++L + +FIF+++GM LFG  +        D  TLP R 
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF----ASERDGDTLPDRK 904

Query: 876 HMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALL 934
           + +    + + VF++L  E W + +++ M  +  +   + F+ +M  GN V+ NL +A+L
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAIL 963

Query: 935 LSSFSSDNLAATDD-DNEMNNLQIAV 959
           +  F ++ ++  +D   +++ +Q+ V
Sbjct: 964 VEGFQAEEISKREDASGQLSCIQLPV 989



 Score =  122 bits (307), Expect = 3e-27
 Identities = 97/377 (25%), Positives = 171/377 (45%), Gaps = 48/377 (12%)

Query: 118 RKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPD----------WTKNVEYTFTGIYTF 167
           R   ++ + +  F  + M  IL NCV + +  P +            +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 168 ESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVS--ALRTFRVLRALK 225
           E ++K++A G   +   +L D WN LDF +++   +   +DL NVS  A+RT RVLR L+
Sbjct: 131 EMVVKMVALGIFGKK-CYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 226 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDS 285
            I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LRN+C        
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249

Query: 286 AFETNTTSYFNGTMDSNGTFV------NVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGN 339
               +   Y+    +    F+      N   S  +     GD        G   P  CG 
Sbjct: 250 PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGD-------GGGGPP--CGL 300

Query: 340 GSDAGQCPEGYICV---------KAG-RNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLY 389
             +A        CV          AG  NP  G  +FD   +A++++F+++T + W ++ 
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 390 QLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQML 449
              + A      I+F+L+I +GSF+++NL L V+A  +          +E K+ E Q M 
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF----------SETKQRESQLMR 410

Query: 450 EQLKKQQEEAQAVAAAS 466
           EQ  +    A  +A+ S
Sbjct: 411 EQRVRFLSNASTLASFS 427



 Score =  112 bits (281), Expect = 3e-24
 Identities = 151/666 (22%), Positives = 284/666 (42%), Gaps = 122/666 (18%)

Query: 365  SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVA 424
            +FD+  WA +++F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 425  MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGELLES 484
              ++ +     E +++++A  Q    QL    +   A  + S        + G G+  + 
Sbjct: 965  EGFQAE-----EISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKC 1019

Query: 485  SSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESED-------SVKRSSF 537
                  L+  S  E    RK       L  +      S PKS S         + +R+S 
Sbjct: 1020 ------LALVSLGEHPELRKSLLPP--LIIHTAATPMSLPKSTSTGLGEALGPASRRTSS 1071

Query: 538  LFSMDGNRLTSDKK----FCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDV------ 587
              S +       K       SPH    +   S ++ RR+S+ S+    GRA  +      
Sbjct: 1072 SGSAEPGAAHEMKSPPSARSSPHSPWSA--ASSWTSRRSSRNSL----GRAPSLKRRSPS 1125

Query: 588  --------GSENDFADDEHSTFEDSESRRDSLFVPHRHG-----ERRNSNGTTTETEVRK 634
                    G   +  D+E S+ E+  S   S    HRH      E ++S       +V  
Sbjct: 1126 GERRSLLSGEGQESQDEEESSEEERASPAGS---DHRHRGSLEREAKSSFDLPDTLQVPG 1182

Query: 635  -RRLSSYQISMEMLEDSSGRQRAVSIASILT---------NTMEELEESRQKCPPCWYRF 684
              R +S + S    +D +G+  +  +A  L          +  +E   S+ +    W R 
Sbjct: 1183 LHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRA 1242

Query: 685  ANVFLIWDCC---DAWL--------KVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHY 733
                 +  CC   D+W         + + L + I+     D  + + I LN + +AME  
Sbjct: 1243 R----LPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER- 1297

Query: 734  PMTEQFSS---VLTVGNLVFTGIFTAEMVLKIIAMDPYY----YFQEGWNIFDGIIVSLS 786
            P  +  S+    LT+ N +FT +F AEM +K++A+   +    Y +  WN+ DG++V +S
Sbjct: 1298 PKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLIS 1357

Query: 787  LMELGLSNVEG--------LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTL 838
            ++++ +S V          L VLR  R LR  ++      L ++++ + +S+  +GN+ +
Sbjct: 1358 VIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVV 1417

Query: 839  VLAIIVFIFAVVGMQLF-GKSYKECVCKIND--------DCTLP--RW--HMNDF--FHS 883
            +      IF ++G+QLF GK +   VC+  D        DC     RW  H  +F     
Sbjct: 1418 ICCAFFIIFGILGVQLFKGKFF---VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474

Query: 884  FLIVFRVLCGE--WIETMWDCMEVAG---------QTMCLIVFMLVMVIGNLVVLNLFLA 932
             L+   VL  +  W++ M+D ++  G             L+ F+  ++I    VLN+F+ 
Sbjct: 1475 ALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVG 1534

Query: 933  LLLSSF 938
            +++ +F
Sbjct: 1535 VVVENF 1540



 Score =  110 bits (274), Expect = 2e-23
 Identities = 79/266 (29%), Positives = 131/266 (49%), Gaps = 24/266 (9%)

Query: 703  LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 762
            LV+ +    ++DL IT  I LN + MAMEHY   +     L + N +FT IF  E V K+
Sbjct: 1592 LVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKL 1651

Query: 763  IAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEG----------LSVLRSFRLLRVFKL 812
            +A     +FQ+ WN  D  IV LS+M + L  +E           + ++R  R+ RV KL
Sbjct: 1652 VAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKL 1711

Query: 813  AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTL 872
             K    +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +  C     C  
Sbjct: 1712 LKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG----DLECDETHPCEG 1767

Query: 873  PRWH--MNDFFHSFLIVFRVLCGE-W----IETMWDCMEVA---GQTMCLIVFMLVMVIG 922
               H    +F  +FL +FRV  G+ W     +T+ DC + +      +  I F+  ++  
Sbjct: 1768 LGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1827

Query: 923  NLVVLNLFLALLLSSFSSDNLAATDD 948
              V++N+ +A+L+      N  A ++
Sbjct: 1828 QFVLVNVVIAVLMKHLEESNKEAKEE 1853



 Score =  105 bits (262), Expect = 4e-22
 Identities = 87/393 (22%), Positives = 163/393 (41%), Gaps = 90/393 (22%)

Query: 109  YILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVE--------YT 160
            YI  P +  R +  +I+ H +F  +++  I  NC+ + +  P     + E        Y 
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316

Query: 161  FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVD---------LGN 211
            FT ++  E  +K++A G+C  +  +LR  WN LD  +++++ +   V          LG 
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376

Query: 212  VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436

Query: 272  NLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQ 331
                                                                 F+V  G+
Sbjct: 1437 K----------------------------------------------------FFVCQGE 1444

Query: 332  KDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQL 391
             D     N SD  +    ++  K      Y +   D    A +SLF L ++D W ++   
Sbjct: 1445 -DTRNITNKSDCAEASYRWVRHK------YNF---DNLGQALMSLFVLASKDGWVDIMYD 1494

Query: 392  TLRAAG----------KTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQ-ATLEEAEQ 440
             L A G             +++F+  + + +F+++N+ + VV   + +  Q    EEA +
Sbjct: 1495 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1554

Query: 441  KEAEFQQMLEQLKKQQEEAQAVAAASAASRDFS 473
            +E +  + LE+ ++ +E+  A A       D+S
Sbjct: 1555 REEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYS 1587



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 70/284 (24%), Positives = 133/284 (46%), Gaps = 41/284 (14%)

Query: 1143 WWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIF 1202
            W  +  T   IV+  +F   I+  IL+++ ++  E  Y EQ + +   LE ++ VFT +F
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLF 786

Query: 1203 ILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRP 1262
             LEMLLK + YG   Y  N +   D +IV +S+  +V       + G +  LRT R +R 
Sbjct: 787  ALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRV 841

Query: 1263 LRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGN 1322
            L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF          
Sbjct: 842  LKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA--------- 892

Query: 1323 MFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRD 1382
                 D + L D             + NFD++    + + Q+ T + W  ++Y  + S  
Sbjct: 893  --SERDGDTLPD-------------RKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST- 936

Query: 1383 VKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1426
                     + +  LYF+  + FG++   NL + ++++ F  ++
Sbjct: 937  ---------SSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971



 Score = 91.3 bits (225), Expect = 8e-18
 Identities = 61/174 (35%), Positives = 96/174 (55%), Gaps = 19/174 (10%)

Query: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRKTIKTMLEYADKVFTYIF 1202
            R  C   V + WFE   + +ILL+   L      EDI  + ++  + +  + D +F + F
Sbjct: 71   RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF-F 128

Query: 1203 ILEMLLKWVA---YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYS---ELGAIKSLRT 1256
             +EM++K VA   +G + Y  + W  LDF IV       +A  L YS   +  +  ++RT
Sbjct: 129  AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAGMLEYSLDLQNVSFSAVRT 181

Query: 1257 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1310
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 182  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 68/269 (25%), Positives = 123/269 (45%), Gaps = 34/269 (12%)

Query: 1474 VTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRH 1533
            V  + F   IMI I +N ++M +E  +Q + +T  L   N+VF  LF  E +LKL+    
Sbjct: 740  VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799

Query: 1534 Y-YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1592
            + Y    +NIFD V+V++S+      E++ +     ++ R  RL    R+L+L++    +
Sbjct: 800  FGYIKNPYNIFDGVIVVISV-----WEIVGQQGGGLSVLRTFRLM---RVLKLVRFLPAL 851

Query: 1593 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM----SNFAYVKKEAGIDDMFNFETFGN 1648
            +  L  LM ++  +    +LL L +FI++I GM      FA  +    + D  NF++   
Sbjct: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLW 911

Query: 1649 SMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIII 1708
            +++ +FQI T   W+ +L                       G     S    +F++ +  
Sbjct: 912  AIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIALMTF 950

Query: 1709 SFLVVVNMYIAVILENFSVATEESAEPLS 1737
               V+ N+ +A+++E F        E  S
Sbjct: 951  GNYVLFNLLVAILVEGFQAEEISKREDAS 979



 Score = 72.0 bits (175), Expect = 5e-12
 Identities = 35/104 (33%), Positives = 61/104 (58%), Gaps = 13/104 (12%)

Query: 1349 VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSF 1408
            +NFDN+G  ++A+ QV T +GW+DIMY  +D+           + Y ++YF++ II GSF
Sbjct: 335  INFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNFIYFILLIIVGSF 384

Query: 1409 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1452
            F +NL + VI   F++ K++   +   M E++ ++ +    L S
Sbjct: 385  FMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 47/155 (30%), Positives = 84/155 (54%), Gaps = 13/155 (8%)

Query: 123 KILVHSLFSMLIMCTILTNCVFMTLS---NPPDWTKNVEYT---FTGIYTFESLIKILAR 176
           KI+    F   IM  IL N + M +     P + T  +E +   FT ++  E L+K+L  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 177 GFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 234
           G     F ++++P+N  D  VIV+  V E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 47/175 (26%), Positives = 88/175 (50%), Gaps = 11/175 (6%)

Query: 708 VMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKII 763
           V +P+ +    + I+LN + + M    E      Q   +L   +      F  EMV+K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 764 AMDPY---YYFQEGWNIFDGIIVSLSLME--LGLSNVEGLSVLRSFRLLRVFKLAKSWPT 818
           A+  +    Y  + WN  D  IV   ++E  L L NV   S +R+ R+LR  +     P+
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLRPLRAINRVPS 196

Query: 819 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP 873
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+    +   C + ++ +LP
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN-RCFLPENFSLP 250



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 68/313 (21%), Positives = 130/313 (41%), Gaps = 87/313 (27%)

Query: 155  KNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSA 214
            K   Y FT I+  ES+ K++A GF      F +D WN LD ++++++ +   ++   V+A
Sbjct: 1633 KICNYIFTVIFVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNA 1688

Query: 215  -----------LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFAL 263
                       +R  R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA 
Sbjct: 1689 SLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAA 1748

Query: 264  IGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFN-WKDYIGDD 322
            +G++LF G+L  +C +  P +              +  + TF N  M+    ++   GD+
Sbjct: 1749 LGVELF-GDL--ECDETHPCEG-------------LGRHATFRNFGMAFLTLFRVSTGDN 1792

Query: 323  SHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQ 382
             +  + D  +D            C +   C     +P Y + SF                
Sbjct: 1793 WNGIMKDTLRD------------CDQESTCYNTVISPIY-FVSF---------------- 1823

Query: 383  DYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKE 442
                                     +    F LVN+++AV+    EE N+   EEAE  E
Sbjct: 1824 -------------------------VLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE-LE 1857

Query: 443  AEFQQMLEQLKKQ 455
            AE +  ++ L  Q
Sbjct: 1858 AELELEMKTLSPQ 1870



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 46/159 (28%), Positives = 71/159 (44%), Gaps = 15/159 (9%)

Query: 1479 FDISIMILICLNMVTMMV----ETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSL--- 1531
            F+   M++I LN VT+ +    E          +L   +      F  E V+K+V+L   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1532 -RHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1590
             +  Y    WN  DF +VI  ++   L        +    F  +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAINRVP 195

Query: 1591 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1629
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 33.1 bits (74), Expect = 2.7
 Identities = 16/59 (27%), Positives = 38/59 (64%), Gaps = 2/59 (3%)

Query: 882 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 939
           ++++ +F+V+  E W++ M+  M+ A      I F+L++++G+  ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 399



 Score = 32.7 bits (73), Expect = 3.6
 Identities = 23/116 (19%), Positives = 46/116 (39%), Gaps = 25/116 (21%)

Query: 1627 NFAYVKKEAGIDDMF----NFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTI 1682
            N  Y    AG  + F    NF+  G + I +FQ+ T  GW  ++  ++++          
Sbjct: 317  NQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------- 366

Query: 1683 HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1738
                       +      +F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 367  -----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.138    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 67,915,537
Number of Sequences: 37866
Number of extensions: 2983262
Number of successful extensions: 18798
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 126
Number of HSP's successfully gapped in prelim test: 158
Number of HSP's that attempted gapping in prelim test: 13763
Number of HSP's gapped (non-prelim): 2420
length of query: 1951
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1834
effective length of database: 13,817,196
effective search space: 25340737464
effective search space used: 25340737464
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.