BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|41393187 NADPH oxidase activator 1 [Homo sapiens] (483 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|41393187 NADPH oxidase activator 1 [Homo sapiens] 1001 0.0 gi|189083742 neutrophil cytosolic factor 2 [Homo sapiens] 196 4e-50 gi|67189970 neutrophil cytosolic factor 2 [Homo sapiens] 196 4e-50 gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho... 55 1e-07 gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 53 7e-07 gi|242117948 SH3 domain-containing protein C1orf113 isoform 2 [H... 53 7e-07 gi|155723000 mixed lineage kinase 4 [Homo sapiens] 51 2e-06 gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo s... 50 5e-06 gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 49 8e-06 gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 49 8e-06 gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 49 8e-06 gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 49 8e-06 gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 49 8e-06 gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 49 8e-06 gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 49 8e-06 gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 49 8e-06 gi|5729856 GRB2-related adaptor protein [Homo sapiens] 48 2e-05 gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens] 47 4e-05 gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H... 47 4e-05 gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho... 45 2e-04 gi|39930351 dynamin binding protein [Homo sapiens] 44 3e-04 gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 44 4e-04 gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 44 4e-04 gi|28875786 FCH and double SH3 domains 1 [Homo sapiens] 44 4e-04 gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 42 0.001 gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 42 0.001 gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 42 0.001 gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ... 42 0.001 gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [... 42 0.001 gi|55956916 myosin IE [Homo sapiens] 41 0.003 >gi|41393187 NADPH oxidase activator 1 [Homo sapiens] Length = 483 Score = 1001 bits (2587), Expect = 0.0 Identities = 483/483 (100%), Positives = 483/483 (100%) Query: 1 MASLGDLVRAWHLGAQAVDRGDWARALHLFSGVPAPPARLCFNAGCVHLLAGDPEAALRA 60 MASLGDLVRAWHLGAQAVDRGDWARALHLFSGVPAPPARLCFNAGCVHLLAGDPEAALRA Sbjct: 1 MASLGDLVRAWHLGAQAVDRGDWARALHLFSGVPAPPARLCFNAGCVHLLAGDPEAALRA 60 Query: 61 FDQAVTKDTCMAVGFFQRGVANFQLARFQEALSDFWLALEQLRGHAAIDYTQLGLRFKLQ 120 FDQAVTKDTCMAVGFFQRGVANFQLARFQEALSDFWLALEQLRGHAAIDYTQLGLRFKLQ Sbjct: 61 FDQAVTKDTCMAVGFFQRGVANFQLARFQEALSDFWLALEQLRGHAAIDYTQLGLRFKLQ 120 Query: 121 AWEVLHNVASAQCQLGLWTEAASSLREAMSKWPEGSLNGLDSALDQVQRRGSLPPRQVPR 180 AWEVLHNVASAQCQLGLWTEAASSLREAMSKWPEGSLNGLDSALDQVQRRGSLPPRQVPR Sbjct: 121 AWEVLHNVASAQCQLGLWTEAASSLREAMSKWPEGSLNGLDSALDQVQRRGSLPPRQVPR 180 Query: 181 GEVFRPHRWHLKHLEPVDFLGKAKVVASAIPDDQGWGVRPQQPQGPGANHDARSLIMDSP 240 GEVFRPHRWHLKHLEPVDFLGKAKVVASAIPDDQGWGVRPQQPQGPGANHDARSLIMDSP Sbjct: 181 GEVFRPHRWHLKHLEPVDFLGKAKVVASAIPDDQGWGVRPQQPQGPGANHDARSLIMDSP 240 Query: 241 RAGTHQGPLDAETEVGADRCTSTAYQEQRPQVEQVGKQAPLSPGLPAMGGPGPGPCEDPA 300 RAGTHQGPLDAETEVGADRCTSTAYQEQRPQVEQVGKQAPLSPGLPAMGGPGPGPCEDPA Sbjct: 241 RAGTHQGPLDAETEVGADRCTSTAYQEQRPQVEQVGKQAPLSPGLPAMGGPGPGPCEDPA 300 Query: 301 GAGGAGAGGSEPLVTVTVQCAFTVALRARRGADLSSLRALLGQALPHQAQLGQLSYLAPG 360 GAGGAGAGGSEPLVTVTVQCAFTVALRARRGADLSSLRALLGQALPHQAQLGQLSYLAPG Sbjct: 301 GAGGAGAGGSEPLVTVTVQCAFTVALRARRGADLSSLRALLGQALPHQAQLGQLSYLAPG 360 Query: 361 EDGHWVPIPEEESLQRAWQDAAACPRGLQLQCRGAGGRPVLYQVVAQHSYSAQGPEDLGF 420 EDGHWVPIPEEESLQRAWQDAAACPRGLQLQCRGAGGRPVLYQVVAQHSYSAQGPEDLGF Sbjct: 361 EDGHWVPIPEEESLQRAWQDAAACPRGLQLQCRGAGGRPVLYQVVAQHSYSAQGPEDLGF 420 Query: 421 RQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFVVPAGPRMSGAPGRLPRSQQG 480 RQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFVVPAGPRMSGAPGRLPRSQQG Sbjct: 421 RQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFVVPAGPRMSGAPGRLPRSQQG 480 Query: 481 DQP 483 DQP Sbjct: 481 DQP 483 >gi|189083742 neutrophil cytosolic factor 2 [Homo sapiens] Length = 526 Score = 196 bits (498), Expect = 4e-50 Identities = 161/528 (30%), Positives = 241/528 (45%), Gaps = 88/528 (16%) Query: 3 SLGDLVRAWHLGAQAVDRGDWARALHLFSGVPAPPARLCFNAGCVHLLAGDPEAALRAFD 62 SL + + W+ G A D+ DW AL FS V P +R+CFN GC++ + + A +AF Sbjct: 2 SLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKAFT 61 Query: 63 QAVTKDTCMAVGFFQRGVANFQLARFQEALSDFWLALEQLRGHAAIDYTQLGLRFKLQAW 122 +++ +D +AV +FQRG+ +Q ++ A+ D AL QLRG+ IDY LGL+FKL A Sbjct: 62 RSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLRGNQLIDYKILGLQFKLFAC 121 Query: 123 EVLHNVASAQCQLGLWTEAASSLREAMSKWPEGSLNGLDSALDQVQRRGSLPPRQVPRGE 182 EVL+N+A + W +A L A S E + +D A++ V ++ P +P G+ Sbjct: 122 EVLYNIAFMYAKKEEWKKAEEQLALATSMKSEPRHSKIDKAMECVWKQKLYEPVVIPVGK 181 Query: 183 VFRPHRWHLKHLEPVDFLGKAKVVASAIPDDQGWGVRPQQPQG------PGANHDARSLI 236 +FRP+ + L D+LGKA VVAS + D G P QPQ P R+L Sbjct: 182 LFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRALE 241 Query: 237 MDSPRA------------GTHQGPLDAETEVGADRCTSTAYQEQR--------------- 269 ++ R G + + G D + + Q+ Sbjct: 242 GEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELRI 301 Query: 270 -PQVEQVGKQAPLS----------PGLPAMGGPGPGPCEDPAGAGGAGAGGSEPL-VTVT 317 PQ + + +P S PG P + PG E+P S P+ T+ Sbjct: 302 HPQQQPQEESSPQSDIPAPPSSKAPGRPQL-SPGQKQKEEP-----KEVKLSVPMPYTLK 355 Query: 318 VQCAFTVALRARRGADLSSLRALLGQALPHQAQLGQLSYLAPGEDGHWVPIPEEESLQRA 377 V +TV ++ + G S +R ++ + L + + +LSY P + VP+ E+S++ A Sbjct: 356 VHYKYTVVMKTQPGLPYSQVRDMVSKKLELRLEHTKLSY-RPRDSNELVPL-SEDSMKDA 413 Query: 378 W-QDAAACPRGLQLQCRGAGG---------------------RPVL---YQVVAQHSYSA 412 W Q C L L C G P L QV A SY A Sbjct: 414 WGQVKNYC---LTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSYEA 470 Query: 413 QGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFV 460 PEDL F++GD + VL + V++ WLEG C G++GIFPK FV Sbjct: 471 TQPEDLEFQEGDIILVLSK-------VNEEWLEGECKGKVGIFPKVFV 511 >gi|67189970 neutrophil cytosolic factor 2 [Homo sapiens] Length = 526 Score = 196 bits (498), Expect = 4e-50 Identities = 161/528 (30%), Positives = 241/528 (45%), Gaps = 88/528 (16%) Query: 3 SLGDLVRAWHLGAQAVDRGDWARALHLFSGVPAPPARLCFNAGCVHLLAGDPEAALRAFD 62 SL + + W+ G A D+ DW AL FS V P +R+CFN GC++ + + A +AF Sbjct: 2 SLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKAFT 61 Query: 63 QAVTKDTCMAVGFFQRGVANFQLARFQEALSDFWLALEQLRGHAAIDYTQLGLRFKLQAW 122 +++ +D +AV +FQRG+ +Q ++ A+ D AL QLRG+ IDY LGL+FKL A Sbjct: 62 RSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLRGNQLIDYKILGLQFKLFAC 121 Query: 123 EVLHNVASAQCQLGLWTEAASSLREAMSKWPEGSLNGLDSALDQVQRRGSLPPRQVPRGE 182 EVL+N+A + W +A L A S E + +D A++ V ++ P +P G+ Sbjct: 122 EVLYNIAFMYAKKEEWKKAEEQLALATSMKSEPRHSKIDKAMECVWKQKLYEPVVIPVGK 181 Query: 183 VFRPHRWHLKHLEPVDFLGKAKVVASAIPDDQGWGVRPQQPQG------PGANHDARSLI 236 +FRP+ + L D+LGKA VVAS + D G P QPQ P R+L Sbjct: 182 LFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRALE 241 Query: 237 MDSPRA------------GTHQGPLDAETEVGADRCTSTAYQEQR--------------- 269 ++ R G + + G D + + Q+ Sbjct: 242 GEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELRI 301 Query: 270 -PQVEQVGKQAPLS----------PGLPAMGGPGPGPCEDPAGAGGAGAGGSEPL-VTVT 317 PQ + + +P S PG P + PG E+P S P+ T+ Sbjct: 302 HPQQQPQEESSPQSDIPAPPSSKAPGRPQL-SPGQKQKEEP-----KEVKLSVPMPYTLK 355 Query: 318 VQCAFTVALRARRGADLSSLRALLGQALPHQAQLGQLSYLAPGEDGHWVPIPEEESLQRA 377 V +TV ++ + G S +R ++ + L + + +LSY P + VP+ E+S++ A Sbjct: 356 VHYKYTVVMKTQPGLPYSQVRDMVSKKLELRLEHTKLSY-RPRDSNELVPL-SEDSMKDA 413 Query: 378 W-QDAAACPRGLQLQCRGAGG---------------------RPVL---YQVVAQHSYSA 412 W Q C L L C G P L QV A SY A Sbjct: 414 WGQVKNYC---LTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSYEA 470 Query: 413 QGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFV 460 PEDL F++GD + VL + V++ WLEG C G++GIFPK FV Sbjct: 471 TQPEDLEFQEGDIILVLSK-------VNEEWLEGECKGKVGIFPKVFV 511 >gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo sapiens] Length = 1118 Score = 55.5 bits (132), Expect = 1e-07 Identities = 43/121 (35%), Positives = 60/121 (49%), Gaps = 14/121 (11%) Query: 346 PHQAQLGQLSYLA----PGEDGHWVPIPEEESLQRAWQDAAACPRGLQLQCRGAGGRPVL 401 P +A LG L+ A PGEDG EEE + ++AAA +L C P+ Sbjct: 3 PSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEE---EEAAAAVGPGELGCDA----PLP 55 Query: 402 YQVVAQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFVV 461 Y A Y A G ++L R GD V+VL ++ V + D+ W G + R+GIFP +V Sbjct: 56 YWT-AVFEYEAAGEDELTLRLGDVVEVLSKDSQV--SGDEGWWTGQLNQRVGIFPSNYVT 112 Query: 462 P 462 P Sbjct: 113 P 113 >gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo sapiens] Length = 756 Score = 52.8 bits (125), Expect = 7e-07 Identities = 26/67 (38%), Positives = 38/67 (56%), Gaps = 7/67 (10%) Query: 399 PVLYQVVAQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKC 458 P +Y+V+ Y + P++L R+GD V VL + + D+ W EG C GR G+FP Sbjct: 183 PEVYRVL--FDYQPEAPDELALRRGDVVKVLSKTTE-----DKGWWEGECQGRRGVFPDN 235 Query: 459 FVVPAGP 465 FV+P P Sbjct: 236 FVLPPPP 242 Score = 33.9 bits (76), Expect = 0.34 Identities = 22/76 (28%), Positives = 38/76 (50%), Gaps = 10/76 (13%) Query: 409 SYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFV--VPAGPR 466 SYS + ++L + G+ V+++ E ++ W G +G++G FP FV + +GP Sbjct: 93 SYSPEQADELKLQAGEIVEMIKE-------IEDGWWLGKKNGQLGAFPSNFVELLDSGPP 145 Query: 467 MSGAPGRLPRSQQGDQ 482 G P +P G Q Sbjct: 146 SLGNPD-MPSVSPGPQ 160 Score = 32.0 bits (71), Expect = 1.3 Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 9/76 (11%) Query: 403 QVVAQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFV-- 460 +V+ Y AQ ++L GD V + P + WL G GR G+FP+ V Sbjct: 2 EVLVLAGYRAQKEDELSLAPGDVVRQVRWVPA------RGWLRGEFGGRYGLFPERLVQE 55 Query: 461 VPAGPRMSGAPGRLPR 476 +P R SG R PR Sbjct: 56 IPETLRGSG-EARRPR 70 >gi|242117948 SH3 domain-containing protein C1orf113 isoform 2 [Homo sapiens] Length = 645 Score = 52.8 bits (125), Expect = 7e-07 Identities = 26/67 (38%), Positives = 38/67 (56%), Gaps = 7/67 (10%) Query: 399 PVLYQVVAQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKC 458 P +Y+V+ Y + P++L R+GD V VL + + D+ W EG C GR G+FP Sbjct: 72 PEVYRVL--FDYQPEAPDELALRRGDVVKVLSKTTE-----DKGWWEGECQGRRGVFPDN 124 Query: 459 FVVPAGP 465 FV+P P Sbjct: 125 FVLPPPP 131 >gi|155723000 mixed lineage kinase 4 [Homo sapiens] Length = 1036 Score = 51.2 bits (121), Expect = 2e-06 Identities = 25/66 (37%), Positives = 37/66 (56%), Gaps = 2/66 (3%) Query: 406 AQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFVVPAGP 465 A + Y A+G ++L R+G V+VL + D ++ D+ W G R+GIFP +V P P Sbjct: 45 ALYDYEARGEDELSLRRGQLVEVLSQ--DAAVSGDEGWWAGQVQRRLGIFPANYVAPCRP 102 Query: 466 RMSGAP 471 S AP Sbjct: 103 AASPAP 108 >gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo sapiens] Length = 486 Score = 50.1 bits (118), Expect = 5e-06 Identities = 31/102 (30%), Positives = 45/102 (44%), Gaps = 12/102 (11%) Query: 359 PGEDGHWVPIPEEESLQRAWQDAAACPRGLQLQCRGAGGRPVLYQVVAQHSYSAQGPEDL 418 P D V PE+ S A ++ CP G GAG + VA + Y +G ++L Sbjct: 393 PEGDYEEVLEPEDSSFSSALAGSSGCPAGA-----GAGAVALGISAVALYDYQGEGSDEL 447 Query: 419 GFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFV 460 F D + D+ + VD+ W G C G G+FP +V Sbjct: 448 SFDPDDVIT------DIEM-VDEGWWRGRCHGHFGLFPANYV 482 >gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo sapiens] Length = 492 Score = 49.3 bits (116), Expect = 8e-06 Identities = 27/74 (36%), Positives = 38/74 (51%), Gaps = 7/74 (9%) Query: 406 AQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFVVPAGP 465 A + + AQ ++L F++GDTV +L + +DQ W EG GR+GIFP +V P Sbjct: 262 AVYDFKAQTSKELSFKKGDTVYILRK-------IDQNWYEGEHHGRVGIFPISYVEKLTP 314 Query: 466 RMSGAPGRLPRSQQ 479 P R P Q Sbjct: 315 PEKAQPARPPPPAQ 328 >gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo sapiens] Length = 1004 Score = 49.3 bits (116), Expect = 8e-06 Identities = 27/74 (36%), Positives = 38/74 (51%), Gaps = 7/74 (9%) Query: 406 AQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFVVPAGP 465 A + + AQ ++L F++GDTV +L + +DQ W EG GR+GIFP +V P Sbjct: 774 AVYDFKAQTSKELSFKKGDTVYILRK-------IDQNWYEGEHHGRVGIFPISYVEKLTP 826 Query: 466 RMSGAPGRLPRSQQ 479 P R P Q Sbjct: 827 PEKAQPARPPPPAQ 840 >gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo sapiens] Length = 824 Score = 49.3 bits (116), Expect = 8e-06 Identities = 27/74 (36%), Positives = 38/74 (51%), Gaps = 7/74 (9%) Query: 406 AQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFVVPAGP 465 A + + AQ ++L F++GDTV +L + +DQ W EG GR+GIFP +V P Sbjct: 594 AVYDFKAQTSKELSFKKGDTVYILRK-------IDQNWYEGEHHGRVGIFPISYVEKLTP 646 Query: 466 RMSGAPGRLPRSQQ 479 P R P Q Sbjct: 647 PEKAQPARPPPPAQ 660 >gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo sapiens] Length = 661 Score = 49.3 bits (116), Expect = 8e-06 Identities = 27/74 (36%), Positives = 38/74 (51%), Gaps = 7/74 (9%) Query: 406 AQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFVVPAGP 465 A + + AQ ++L F++GDTV +L + +DQ W EG GR+GIFP +V P Sbjct: 431 AVYDFKAQTSKELSFKKGDTVYILRK-------IDQNWYEGEHHGRVGIFPISYVEKLTP 483 Query: 466 RMSGAPGRLPRSQQ 479 P R P Q Sbjct: 484 PEKAQPARPPPPAQ 497 >gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo sapiens] Length = 731 Score = 49.3 bits (116), Expect = 8e-06 Identities = 27/74 (36%), Positives = 38/74 (51%), Gaps = 7/74 (9%) Query: 406 AQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFVVPAGP 465 A + + AQ ++L F++GDTV +L + +DQ W EG GR+GIFP +V P Sbjct: 501 AVYDFKAQTSKELSFKKGDTVYILRK-------IDQNWYEGEHHGRVGIFPISYVEKLTP 553 Query: 466 RMSGAPGRLPRSQQ 479 P R P Q Sbjct: 554 PEKAQPARPPPPAQ 567 >gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo sapiens] Length = 644 Score = 49.3 bits (116), Expect = 8e-06 Identities = 27/74 (36%), Positives = 38/74 (51%), Gaps = 7/74 (9%) Query: 406 AQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFVVPAGP 465 A + + AQ ++L F++GDTV +L + +DQ W EG GR+GIFP +V P Sbjct: 414 AVYDFKAQTSKELSFKKGDTVYILRK-------IDQNWYEGEHHGRVGIFPISYVEKLTP 466 Query: 466 RMSGAPGRLPRSQQ 479 P R P Q Sbjct: 467 PEKAQPARPPPPAQ 480 >gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo sapiens] Length = 1100 Score = 49.3 bits (116), Expect = 8e-06 Identities = 27/74 (36%), Positives = 38/74 (51%), Gaps = 7/74 (9%) Query: 406 AQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFVVPAGP 465 A + + AQ ++L F++GDTV +L + +DQ W EG GR+GIFP +V P Sbjct: 870 AVYDFKAQTSKELSFKKGDTVYILRK-------IDQNWYEGEHHGRVGIFPISYVEKLTP 922 Query: 466 RMSGAPGRLPRSQQ 479 P R P Q Sbjct: 923 PEKAQPARPPPPAQ 936 >gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo sapiens] Length = 666 Score = 49.3 bits (116), Expect = 8e-06 Identities = 27/74 (36%), Positives = 38/74 (51%), Gaps = 7/74 (9%) Query: 406 AQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFVVPAGP 465 A + + AQ ++L F++GDTV +L + +DQ W EG GR+GIFP +V P Sbjct: 436 AVYDFKAQTSKELSFKKGDTVYILRK-------IDQNWYEGEHHGRVGIFPISYVEKLTP 488 Query: 466 RMSGAPGRLPRSQQ 479 P R P Q Sbjct: 489 PEKAQPARPPPPAQ 502 >gi|5729856 GRB2-related adaptor protein [Homo sapiens] Length = 217 Score = 48.1 bits (113), Expect = 2e-05 Identities = 25/57 (43%), Positives = 32/57 (56%), Gaps = 7/57 (12%) Query: 406 AQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFVVP 462 AQ +SAQ P L FR+GD ++VL E P D W G GR+G FP+ +V P Sbjct: 165 AQFDFSAQDPSQLSFRRGDIIEVL-ERP------DPHWWRGRSCGRVGFFPRSYVQP 214 >gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens] Length = 729 Score = 47.0 bits (110), Expect = 4e-05 Identities = 28/69 (40%), Positives = 38/69 (55%), Gaps = 9/69 (13%) Query: 405 VAQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEG--HCDGRIGIFPKCFVVP 462 VA HSYSA GP++L ++G+ V VL + D WL G GR+GIFP +V+P Sbjct: 386 VALHSYSAHGPDELDLQKGEGVRVLGKCQD-------GWLRGVSLVTGRVGIFPNNYVIP 438 Query: 463 AGPRMSGAP 471 + S P Sbjct: 439 IFRKTSSFP 447 Score = 31.2 bits (69), Expect = 2.2 Identities = 18/62 (29%), Positives = 28/62 (45%), Gaps = 7/62 (11%) Query: 401 LYQVVAQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFV 460 LY + ++ + L F + D + V+ VD+ W EG ++GIFP FV Sbjct: 195 LYNFDLRGKDKSENQDCLTFLKDDIITVISR-------VDENWAEGKLGDKVGIFPILFV 247 Query: 461 VP 462 P Sbjct: 248 EP 249 Score = 29.3 bits (64), Expect = 8.3 Identities = 15/48 (31%), Positives = 24/48 (50%), Gaps = 7/48 (14%) Query: 409 SYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFP 456 +Y Q P DL F +GD + + + +D+ W +G +G G FP Sbjct: 135 NYRGQNPGDLRFNKGDIILLRRQ-------LDENWYQGEINGISGNFP 175 >gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo sapiens] Length = 954 Score = 47.0 bits (110), Expect = 4e-05 Identities = 28/75 (37%), Positives = 38/75 (50%), Gaps = 6/75 (8%) Query: 406 AQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHC-DGRIGIFPKCFVVPAG 464 A Y A G E+L R+GD V VL + D ++ D+ W G GR+G+FP +V P Sbjct: 23 AVFDYEAAGDEELTLRRGDRVQVLSQ--DCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGA 80 Query: 465 PRMSGAPGRLPRSQQ 479 P AP L Q+ Sbjct: 81 P---AAPAGLQLPQE 92 >gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo sapiens] Length = 847 Score = 44.7 bits (104), Expect = 2e-04 Identities = 26/80 (32%), Positives = 38/80 (47%), Gaps = 11/80 (13%) Query: 394 GAGGRPVLYQVVAQHS---------YSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWL 444 G GGRP A ++ Y G ++L R+GD V+VL D ++ D+ W Sbjct: 27 GGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSR--DAAISGDEGWW 84 Query: 445 EGHCDGRIGIFPKCFVVPAG 464 G G++GIFP +V G Sbjct: 85 AGQVGGQVGIFPSNYVSRGG 104 >gi|39930351 dynamin binding protein [Homo sapiens] Length = 1577 Score = 43.9 bits (102), Expect = 3e-04 Identities = 26/63 (41%), Positives = 34/63 (53%), Gaps = 7/63 (11%) Query: 403 QVVAQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFVVP 462 Q A SAQ E+L FR+GD + ++ VP + W EG +GR GIFP+ FV Sbjct: 149 QARALMGLSAQLDEELDFREGDVITII----GVP---EPGWFEGELEGRRGIFPEGFVEL 201 Query: 463 AGP 465 GP Sbjct: 202 LGP 204 Score = 39.7 bits (91), Expect = 0.006 Identities = 21/56 (37%), Positives = 28/56 (50%), Gaps = 7/56 (12%) Query: 405 VAQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFV 460 VA + + A P +L F GD + +L ++ WLEG GR GIFP FV Sbjct: 249 VALYRFQALEPNELDFEVGDKIRILA-------TLEDGWLEGSLKGRTGIFPYRFV 297 >gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] Length = 1220 Score = 43.5 bits (101), Expect = 4e-04 Identities = 19/58 (32%), Positives = 34/58 (58%), Gaps = 7/58 (12%) Query: 403 QVVAQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFV 460 QV+ + Y+AQ ++L F +G ++VL +E D W +G +G++G+FP +V Sbjct: 1159 QVIGMYDYTAQNDDELAFNKGQIINVLNKE-------DPDWWKGEVNGQVGLFPSNYV 1209 Score = 33.1 bits (74), Expect = 0.58 Identities = 19/71 (26%), Positives = 32/71 (45%), Gaps = 8/71 (11%) Query: 403 QVVAQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFVVP 462 + +A ++Y + DL F+QGD + V ++ D W G + G+FP +V Sbjct: 1006 EFIAMYTYESSEQGDLTFQQGDVILVTKKDGD--------WWTGTVGDKAGVFPSNYVRL 1057 Query: 463 AGPRMSGAPGR 473 SG G+ Sbjct: 1058 KDSEGSGTAGK 1068 Score = 32.3 bits (72), Expect = 0.99 Identities = 28/88 (31%), Positives = 37/88 (42%), Gaps = 15/88 (17%) Query: 396 GGRPVLYQVVAQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGR---- 451 G +P + QV+A SY+A GPE L G + + + P W EG R Sbjct: 1073 GKKPEIAQVIA--SYTATGPEQLTLAPGQLILIRKKNPG-------GWWEGELQARGKKR 1123 Query: 452 -IGIFPKCFVVPAGPRMSG-APGRLPRS 477 IG FP +V P S P P+S Sbjct: 1124 QIGWFPANYVKLLSPGTSKITPTEPPKS 1151 Score = 31.2 bits (69), Expect = 2.2 Identities = 22/88 (25%), Positives = 38/88 (43%), Gaps = 5/88 (5%) Query: 369 PEEESLQRAWQDAAACPRGLQLQCRGAGGRPVLYQVVAQHSYSAQGPEDLGFRQGDTVDV 428 P + ++Q W A P + Q + V Y+ A + + ++ +++ + GD V V Sbjct: 715 PAKPAVQAPWSTAEKGPLTISAQ---ENVKVVYYR--ALYPFESRSHDEITIQPGDIVMV 769 Query: 429 LCEEPDVPLAVDQAWLEGHCDGRIGIFP 456 E D + WL G G+ G FP Sbjct: 770 KGEWVDESQTGEPGWLGGELKGKTGWFP 797 >gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] Length = 1721 Score = 43.5 bits (101), Expect = 4e-04 Identities = 19/58 (32%), Positives = 34/58 (58%), Gaps = 7/58 (12%) Query: 403 QVVAQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFV 460 QV+ + Y+AQ ++L F +G ++VL +E D W +G +G++G+FP +V Sbjct: 1159 QVIGMYDYTAQNDDELAFNKGQIINVLNKE-------DPDWWKGEVNGQVGLFPSNYV 1209 Score = 33.1 bits (74), Expect = 0.58 Identities = 19/71 (26%), Positives = 32/71 (45%), Gaps = 8/71 (11%) Query: 403 QVVAQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFVVP 462 + +A ++Y + DL F+QGD + V ++ D W G + G+FP +V Sbjct: 1006 EFIAMYTYESSEQGDLTFQQGDVILVTKKDGD--------WWTGTVGDKAGVFPSNYVRL 1057 Query: 463 AGPRMSGAPGR 473 SG G+ Sbjct: 1058 KDSEGSGTAGK 1068 Score = 32.3 bits (72), Expect = 0.99 Identities = 28/88 (31%), Positives = 37/88 (42%), Gaps = 15/88 (17%) Query: 396 GGRPVLYQVVAQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGR---- 451 G +P + QV+A SY+A GPE L G + + + P W EG R Sbjct: 1073 GKKPEIAQVIA--SYTATGPEQLTLAPGQLILIRKKNPG-------GWWEGELQARGKKR 1123 Query: 452 -IGIFPKCFVVPAGPRMSG-APGRLPRS 477 IG FP +V P S P P+S Sbjct: 1124 QIGWFPANYVKLLSPGTSKITPTEPPKS 1151 Score = 31.2 bits (69), Expect = 2.2 Identities = 22/88 (25%), Positives = 38/88 (43%), Gaps = 5/88 (5%) Query: 369 PEEESLQRAWQDAAACPRGLQLQCRGAGGRPVLYQVVAQHSYSAQGPEDLGFRQGDTVDV 428 P + ++Q W A P + Q + V Y+ A + + ++ +++ + GD V V Sbjct: 715 PAKPAVQAPWSTAEKGPLTISAQ---ENVKVVYYR--ALYPFESRSHDEITIQPGDIVMV 769 Query: 429 LCEEPDVPLAVDQAWLEGHCDGRIGIFP 456 E D + WL G G+ G FP Sbjct: 770 KGEWVDESQTGEPGWLGGELKGKTGWFP 797 >gi|28875786 FCH and double SH3 domains 1 [Homo sapiens] Length = 690 Score = 43.5 bits (101), Expect = 4e-04 Identities = 28/96 (29%), Positives = 39/96 (40%), Gaps = 8/96 (8%) Query: 385 PRGLQLQCRGAGGRPVLYQVVAQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWL 444 P Q G P + A +SY+ Q E+L F +G + +L D VD + Sbjct: 532 PESSQDSDNPCGAEPTAFLAQALYSYTGQSAEELSFPEGALIRLLPRAQD---GVDDGFW 588 Query: 445 EGHCDGRIGIFPKCFV-----VPAGPRMSGAPGRLP 475 G GR+G+FP V P P +S LP Sbjct: 589 RGEFGGRVGVFPSLLVEELLGPPGPPELSDPEQMLP 624 >gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] Length = 731 Score = 42.4 bits (98), Expect = 0.001 Identities = 22/74 (29%), Positives = 35/74 (47%), Gaps = 7/74 (9%) Query: 406 AQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFVVPAGP 465 A HS++A+ +DL F++GD + +L +D W G R GIFP FV P Sbjct: 609 ALHSFTAETSDDLSFKRGDRIQIL-------ERLDSDWCRGRLQDREGIFPAVFVRPCPA 661 Query: 466 RMSGAPGRLPRSQQ 479 +P+ ++ Sbjct: 662 EAKSMLAIVPKGRK 675 Score = 34.7 bits (78), Expect = 0.20 Identities = 18/56 (32%), Positives = 28/56 (50%), Gaps = 7/56 (12%) Query: 405 VAQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFV 460 V H + A+ +DL G+ V +L + +D W G+C +IGIFP +V Sbjct: 442 VVLHDFPAEQVDDLNLTSGEIVYLLEK-------IDTDWYRGNCRNQIGIFPANYV 490 Score = 34.3 bits (77), Expect = 0.26 Identities = 20/58 (34%), Positives = 30/58 (51%), Gaps = 7/58 (12%) Query: 405 VAQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFVVP 462 VA+ Y + ++L F +G+ + +L E V++ W G GR GIFP FV P Sbjct: 518 VARFEYIGEQKDELSFSEGEII-ILKEY------VNEEWARGEVRGRTGIFPLNFVEP 568 Score = 34.3 bits (77), Expect = 0.26 Identities = 16/55 (29%), Positives = 28/55 (50%), Gaps = 7/55 (12%) Query: 406 AQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFV 460 A + + + ++L F+ GD + L +VD W+ G G+ GIFPK ++ Sbjct: 678 ALYDFRGENEDELSFKAGDIITEL-------ESVDDDWMSGELMGKSGIFPKNYI 725 >gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] Length = 767 Score = 42.4 bits (98), Expect = 0.001 Identities = 22/74 (29%), Positives = 35/74 (47%), Gaps = 7/74 (9%) Query: 406 AQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFVVPAGP 465 A HS++A+ +DL F++GD + +L +D W G R GIFP FV P Sbjct: 645 ALHSFTAETSDDLSFKRGDRIQIL-------ERLDSDWCRGRLQDREGIFPAVFVRPCPA 697 Query: 466 RMSGAPGRLPRSQQ 479 +P+ ++ Sbjct: 698 EAKSMLAIVPKGRK 711 Score = 34.7 bits (78), Expect = 0.20 Identities = 18/56 (32%), Positives = 28/56 (50%), Gaps = 7/56 (12%) Query: 405 VAQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFV 460 V H + A+ +DL G+ V +L + +D W G+C +IGIFP +V Sbjct: 478 VVLHDFPAEQVDDLNLTSGEIVYLLEK-------IDTDWYRGNCRNQIGIFPANYV 526 Score = 34.3 bits (77), Expect = 0.26 Identities = 20/58 (34%), Positives = 30/58 (51%), Gaps = 7/58 (12%) Query: 405 VAQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFVVP 462 VA+ Y + ++L F +G+ + +L E V++ W G GR GIFP FV P Sbjct: 554 VARFEYIGEQKDELSFSEGEII-ILKEY------VNEEWARGEVRGRTGIFPLNFVEP 604 Score = 34.3 bits (77), Expect = 0.26 Identities = 16/55 (29%), Positives = 28/55 (50%), Gaps = 7/55 (12%) Query: 406 AQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFV 460 A + + + ++L F+ GD + L +VD W+ G G+ GIFPK ++ Sbjct: 714 ALYDFRGENEDELSFKAGDIITEL-------ESVDDDWMSGELMGKSGIFPKNYI 761 >gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] Length = 790 Score = 42.4 bits (98), Expect = 0.001 Identities = 22/74 (29%), Positives = 35/74 (47%), Gaps = 7/74 (9%) Query: 406 AQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFVVPAGP 465 A HS++A+ +DL F++GD + +L +D W G R GIFP FV P Sbjct: 668 ALHSFTAETSDDLSFKRGDRIQIL-------ERLDSDWCRGRLQDREGIFPAVFVRPCPA 720 Query: 466 RMSGAPGRLPRSQQ 479 +P+ ++ Sbjct: 721 EAKSMLAIVPKGRK 734 Score = 34.7 bits (78), Expect = 0.20 Identities = 18/56 (32%), Positives = 28/56 (50%), Gaps = 7/56 (12%) Query: 405 VAQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFV 460 V H + A+ +DL G+ V +L + +D W G+C +IGIFP +V Sbjct: 501 VVLHDFPAEQVDDLNLTSGEIVYLLEK-------IDTDWYRGNCRNQIGIFPANYV 549 Score = 34.3 bits (77), Expect = 0.26 Identities = 20/58 (34%), Positives = 30/58 (51%), Gaps = 7/58 (12%) Query: 405 VAQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFVVP 462 VA+ Y + ++L F +G+ + +L E V++ W G GR GIFP FV P Sbjct: 577 VARFEYIGEQKDELSFSEGEII-ILKEY------VNEEWARGEVRGRTGIFPLNFVEP 627 Score = 34.3 bits (77), Expect = 0.26 Identities = 16/55 (29%), Positives = 28/55 (50%), Gaps = 7/55 (12%) Query: 406 AQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCFV 460 A + + + ++L F+ GD + L +VD W+ G G+ GIFPK ++ Sbjct: 737 ALYDFRGENEDELSFKAGDIITEL-------ESVDDDWMSGELMGKSGIFPKNYI 784 >gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 [Homo sapiens] Length = 878 Score = 42.0 bits (97), Expect = 0.001 Identities = 21/65 (32%), Positives = 35/65 (53%), Gaps = 5/65 (7%) Query: 400 VLYQVVAQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCF 459 V+ VA+++++A+ +L R+GD V + + DQ W +G +GRIG FP + Sbjct: 817 VIGTAVARYNFAARDMRELSLREGDVVRIYSR-----IGGDQGWWKGETNGRIGWFPSTY 871 Query: 460 VVPAG 464 V G Sbjct: 872 VEEEG 876 >gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [Homo sapiens] Length = 839 Score = 42.0 bits (97), Expect = 0.001 Identities = 21/65 (32%), Positives = 35/65 (53%), Gaps = 5/65 (7%) Query: 400 VLYQVVAQHSYSAQGPEDLGFRQGDTVDVLCEEPDVPLAVDQAWLEGHCDGRIGIFPKCF 459 V+ VA+++++A+ +L R+GD V + + DQ W +G +GRIG FP + Sbjct: 778 VIGTAVARYNFAARDMRELSLREGDVVRIYSR-----IGGDQGWWKGETNGRIGWFPSTY 832 Query: 460 VVPAG 464 V G Sbjct: 833 VEEEG 837 >gi|55956916 myosin IE [Homo sapiens] Length = 1108 Score = 40.8 bits (94), Expect = 0.003 Identities = 27/90 (30%), Positives = 40/90 (44%), Gaps = 15/90 (16%) Query: 379 QDAAACPRGLQLQCRGAGGRPV--------LYQVVAQHSYSAQGPEDLGFRQGDTVDVLC 430 Q AA R + AGGRP + Q A ++Y AQ ++L F D +D++ Sbjct: 1023 QGAAGVRRQTTSRPPPAGGRPKPQPKPKPQVPQCKALYAYDAQDTDELSFNANDIIDIIK 1082 Query: 431 EEPDVPLAVDQAWLEGHCDGRIGIFPKCFV 460 E+P W G G+ G+FP +V Sbjct: 1083 EDP-------SGWWTGRLRGKQGLFPNNYV 1105 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.319 0.136 0.435 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 22,390,725 Number of Sequences: 37866 Number of extensions: 1214648 Number of successful extensions: 6831 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 61 Number of HSP's successfully gapped in prelim test: 213 Number of HSP's that attempted gapping in prelim test: 6317 Number of HSP's gapped (non-prelim): 663 length of query: 483 length of database: 18,247,518 effective HSP length: 106 effective length of query: 377 effective length of database: 14,233,722 effective search space: 5366113194 effective search space used: 5366113194 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.