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Search of human proteins with 41281564
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41281564 WD repeat domain 37 [Homo sapiens]
(494 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41281564 WD repeat domain 37 [Homo sapiens] 993 0.0
gi|32189425 WD repeat domain 69 [Homo sapiens] 101 2e-21
gi|217330644 WD repeat domain 12 protein [Homo sapiens] 94 4e-19
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 88 2e-17
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 88 2e-17
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 88 2e-17
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 87 3e-17
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 87 3e-17
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 87 5e-17
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 87 5e-17
gi|148536855 coatomer protein complex, subunit alpha isoform 1 [... 86 6e-17
gi|148536853 coatomer protein complex, subunit alpha isoform 2 [... 86 6e-17
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 86 8e-17
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 86 8e-17
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 86 8e-17
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 84 3e-16
gi|113865883 WD repeat domain 38 [Homo sapiens] 82 1e-15
gi|21071067 TBP-associated factor 5 [Homo sapiens] 81 2e-15
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 80 4e-15
gi|4757988 WD repeat domain 39 [Homo sapiens] 79 1e-14
gi|16554629 WD repeat domain 5 [Homo sapiens] 78 2e-14
gi|16554627 WD repeat domain 5 [Homo sapiens] 78 2e-14
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 78 2e-14
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 78 2e-14
gi|23199987 WD repeat domain 5B [Homo sapiens] 76 6e-14
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 75 1e-13
gi|26665869 WD repeat domain 51B [Homo sapiens] 75 1e-13
gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)... 75 2e-13
gi|13376840 WD repeat domain 61 [Homo sapiens] 73 7e-13
gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens] 72 9e-13
>gi|41281564 WD repeat domain 37 [Homo sapiens]
Length = 494
Score = 993 bits (2567), Expect = 0.0
Identities = 494/494 (100%), Positives = 494/494 (100%)
Query: 1 MPTESASCSTARQTKQKRKSHSLSIRRTNSSEQERTGLPRDMLEGQDSKLPSSVRSTLLE 60
MPTESASCSTARQTKQKRKSHSLSIRRTNSSEQERTGLPRDMLEGQDSKLPSSVRSTLLE
Sbjct: 1 MPTESASCSTARQTKQKRKSHSLSIRRTNSSEQERTGLPRDMLEGQDSKLPSSVRSTLLE 60
Query: 61 LFGQIEREFENLYIENLELRREIDTLNERLAAEGQAIDGAELSKGQLKTKASHSTSQLSQ 120
LFGQIEREFENLYIENLELRREIDTLNERLAAEGQAIDGAELSKGQLKTKASHSTSQLSQ
Sbjct: 61 LFGQIEREFENLYIENLELRREIDTLNERLAAEGQAIDGAELSKGQLKTKASHSTSQLSQ 120
Query: 121 KLKTTYKASTSKIVSSFKTTTSRAACQLVKEYIGHRDGIWDVSVAKTQPVVLGTASADHT 180
KLKTTYKASTSKIVSSFKTTTSRAACQLVKEYIGHRDGIWDVSVAKTQPVVLGTASADHT
Sbjct: 121 KLKTTYKASTSKIVSSFKTTTSRAACQLVKEYIGHRDGIWDVSVAKTQPVVLGTASADHT 180
Query: 181 ALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLPTPQPVAD 240
ALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLPTPQPVAD
Sbjct: 181 ALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLPTPQPVAD 240
Query: 241 TSISGEDEVECSDKDEPDLDGDVSSDCPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTAS 300
TSISGEDEVECSDKDEPDLDGDVSSDCPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTAS
Sbjct: 241 TSISGEDEVECSDKDEPDLDGDVSSDCPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTAS 300
Query: 301 WDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSV 360
WDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSV
Sbjct: 301 WDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSV 360
Query: 361 NVFQGHTDTVTSAVFTVGDNVVSGSDDRTVKVWDLKNMRSPIATIRTDSAINRINVCVGQ 420
NVFQGHTDTVTSAVFTVGDNVVSGSDDRTVKVWDLKNMRSPIATIRTDSAINRINVCVGQ
Sbjct: 361 NVFQGHTDTVTSAVFTVGDNVVSGSDDRTVKVWDLKNMRSPIATIRTDSAINRINVCVGQ 420
Query: 421 KIIALPHDNRQVRLFDMSGVRLARLPRSSRQGHRRMVCCSAWSEDHPVCNLFTCGFDRQA 480
KIIALPHDNRQVRLFDMSGVRLARLPRSSRQGHRRMVCCSAWSEDHPVCNLFTCGFDRQA
Sbjct: 421 KIIALPHDNRQVRLFDMSGVRLARLPRSSRQGHRRMVCCSAWSEDHPVCNLFTCGFDRQA 480
Query: 481 IGWNINIPALLQEK 494
IGWNINIPALLQEK
Sbjct: 481 IGWNINIPALLQEK 494
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 101 bits (251), Expect = 2e-21
Identities = 64/249 (25%), Positives = 115/249 (46%), Gaps = 15/249 (6%)
Query: 154 GHRDGIWDVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQL 213
GHR+ ++ ++ + T S D T LWS+ETGKC + GH + + F+P L
Sbjct: 132 GHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTL 191
Query: 214 ALTASGDQTAHIWR-------YAVQLPTPQPVADTSISGEDEVECSDKDEPDLDGDVSSD 266
T S D TA +W Y ++ + + ++ + + D + D + D +
Sbjct: 192 VATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTG 251
Query: 267 CPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQEL 326
+ L H + ++ + +T S D+T L+D + V +LTGHD E+
Sbjct: 252 RK-----VNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEI 306
Query: 327 THCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTV-GDNVVSGS 385
C T +L+ T+S D T R+ F + + +GH ++ F G+++++GS
Sbjct: 307 LDSCFDYTGKLIATASADGTARI--FSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGS 364
Query: 386 DDRTVKVWD 394
D+T ++WD
Sbjct: 365 SDKTARIWD 373
Score = 82.0 bits (201), Expect = 1e-15
Identities = 51/184 (27%), Positives = 81/184 (44%), Gaps = 12/184 (6%)
Query: 174 TASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLP 233
T S DHT ++W +TG+ + GH ++S F+ L LT S D+T +W
Sbjct: 236 TGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWD-----A 290
Query: 234 TPQPVADTSISGEDEV--ECSDKD-----EPDLDGDVSSDCPTIRVPLTSLKSHQGVVIA 286
T T +DE+ C D DG R + L+ H+G +
Sbjct: 291 TNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISK 350
Query: 287 SDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTT 346
+ G +T S D+TA ++D +T + + L GH E+ C + +V+T S+D T
Sbjct: 351 ISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNT 410
Query: 347 FRLW 350
R+W
Sbjct: 411 CRIW 414
Score = 79.7 bits (195), Expect = 6e-15
Identities = 46/123 (37%), Positives = 67/123 (54%), Gaps = 4/123 (3%)
Query: 274 LTSLKSHQGVVIASDWLVG-GKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTH 332
L +L+ H+ VV A + G + T S+D+T L+ VET + H+ GH E+ +
Sbjct: 127 LNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFN 186
Query: 333 PTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVF-TVGDNVVSGSDDRTVK 391
P LV T S DTT +LWD ++ V +GH+ + S F T GD +++GS D TV
Sbjct: 187 PQSTLVATGSMDTTAKLWDIQNG--EEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVV 244
Query: 392 VWD 394
VWD
Sbjct: 245 VWD 247
Score = 66.2 bits (160), Expect = 6e-11
Identities = 57/226 (25%), Positives = 90/226 (39%), Gaps = 44/226 (19%)
Query: 174 TASADHTALLWSIETGKCLVKYAGHVGSVNSIKFH-PSEQLALTASGDQTAHIWRYAVQL 232
T S D T LW +G+ L GH V +I F+ P T S D+T +W
Sbjct: 109 TGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLW------ 162
Query: 233 PTPQPVADTSISGEDEVECSDKDEPDLDGDVSSDCPTIRVPLTSLKSHQGVVIASDWLVG 292
VE + C + + H ++ +
Sbjct: 163 ---------------SVE-------------TGKC------YHTFRGHTAEIVCLSFNPQ 188
Query: 293 GKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDF 352
T S D TA L+D++ E V++L GH E+ + + ++T S D T +WD
Sbjct: 189 STLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDA 248
Query: 353 RDPSIHSVNVFQGHTDTVTSAVFTVGDNVV-SGSDDRTVKVWDLKN 397
+ VN+ GH ++SA F +++ +GS D+T K+WD N
Sbjct: 249 --DTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATN 292
Score = 50.1 bits (118), Expect = 5e-06
Identities = 29/86 (33%), Positives = 41/86 (47%), Gaps = 1/86 (1%)
Query: 142 SRAACQLVKEYIGHRDGIWDVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGS 201
S A + + + GH I +S Q L T S+D TA +W +TG+CL GH
Sbjct: 331 SAATRKCIAKLEGHEGEISKISF-NPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDE 389
Query: 202 VNSIKFHPSEQLALTASGDQTAHIWR 227
+ S F+ + +T S D T IWR
Sbjct: 390 IFSCAFNYKGNIVITGSKDNTCRIWR 415
>gi|217330644 WD repeat domain 12 protein [Homo sapiens]
Length = 423
Score = 93.6 bits (231), Expect = 4e-19
Identities = 79/261 (30%), Positives = 128/261 (49%), Gaps = 29/261 (11%)
Query: 153 IGHRDGIWDVSVAKTQPV--VLGTASADHTALLW--SIETGKCLVKYA--GHVGSVNSIK 206
+GH D + DV+ K + +L +AS D T LLW ++E K + GH GSV+SI
Sbjct: 137 VGHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNVERNKVKALHCCRGHAGSVDSIA 196
Query: 207 FHPSEQLALTASGDQTAHIWRYAVQLPTPQPVADTSISGEDEVECSDKDEPDLDGDVSSD 266
S + S D+ IW +PT + EDE+E + +
Sbjct: 197 VDGSGTKFCSGSWDKMLKIWS---TVPTDE---------EDEME--ESTNRPRKKQKTEQ 242
Query: 267 CPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQEL 326
R P+ +L H V + W ++ +ASWD T ++DVE+ L +LTG+ ++
Sbjct: 243 LGLTRTPIVTLSGHMEAVSSVLWS-DAEEICSASWDHTIRVWDVESGSLKSTLTGN--KV 299
Query: 327 THCCTH-PTQRLVVTSSRDTTFRLWDFR--DPSIHSVNVFQGHTDTVTSAVF--TVGDNV 381
+C ++ P + + + S D RLWD R D S+ S+++ HT VTS + T +
Sbjct: 300 FNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSL-TSHTGWVTSVKWSPTHEQQL 358
Query: 382 VSGSDDRTVKVWDLKNMRSPI 402
+SGS D VK+WD ++ ++P+
Sbjct: 359 ISGSLDNIVKLWDTRSCKAPL 379
Score = 57.0 bits (136), Expect = 4e-08
Identities = 68/310 (21%), Positives = 121/310 (39%), Gaps = 61/310 (19%)
Query: 160 WDVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLA---LT 216
W S+ + +L T S D T+ +WS+E GK ++ GH V + + + L+ L+
Sbjct: 103 WISSIKGAEEWIL-TGSYDKTSRIWSLE-GKSIMTIVGHTDVVKDVAWVKKDSLSCLLLS 160
Query: 217 ASGDQTAHIWRYAVQLPTPQPVADTSISGEDEVECSDKDEPDLDGDVSSDCPTIRVPLTS 276
AS DQT +W + V+ ++V+ L
Sbjct: 161 ASMDQTILLWEWNVE--------------RNKVKA----------------------LHC 184
Query: 277 LKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQR 336
+ H G V + G + + SWD+ ++ T + E+ P ++
Sbjct: 185 CRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVP-------TDEEDEMEESTNRPRKK 237
Query: 337 LVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDNVVSGSDDRTVKVWDLK 396
T +L R P + GH + V+S +++ + + S S D T++VWD++
Sbjct: 238 -------QKTEQLGLTRTPIV----TLSGHMEAVSSVLWSDAEEICSASWDHTIRVWDVE 286
Query: 397 NMRSPIATIRTDSAINRINVCVGQKIIALPHDNRQVRLFDMSGVRLARLPRSSRQGHRRM 456
+ S +T+ + N I+ K +A +R +RL+D + L S H
Sbjct: 287 S-GSLKSTLTGNKVFNCISYSPLCKRLASGSTDRHIRLWD-PRTKDGSLVSLSLTSHTGW 344
Query: 457 VCCSAWSEDH 466
V WS H
Sbjct: 345 VTSVKWSPTH 354
Score = 46.6 bits (109), Expect = 5e-05
Identities = 47/213 (22%), Positives = 89/213 (41%), Gaps = 34/213 (15%)
Query: 288 DWLVGGKQA----VTASWDRTANLYDVETSELVHSLTGHD---QELTHCCTHPTQRLVVT 340
DW+ K A +T S+D+T+ ++ +E ++ ++ GH +++ L+++
Sbjct: 102 DWISSIKGAEEWILTGSYDKTSRIWSLEGKSIM-TIVGHTDVVKDVAWVKKDSLSCLLLS 160
Query: 341 SSRDTTFRLWDFRDP--SIHSVNVFQGHTDTVTS-AVFTVGDNVVSGSDDRTVKVWDLKN 397
+S D T LW++ + +++ +GH +V S AV G SGS D+ +K+W
Sbjct: 161 ASMDQTILLWEWNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIW---- 216
Query: 398 MRSPIATIRTDSAINRINVCVGQKIIALPHDNRQVRLFDMSGVRLARLPRSSRQGHRRMV 457
+T+ TD NR + + L R P + GH V
Sbjct: 217 -----STVPTDEEDEMEE-----------STNRPRKKQKTEQLGLTRTPIVTLSGHMEAV 260
Query: 458 CCSAWSEDHPVCNLFTCGFDRQAIGWNINIPAL 490
WS+ +C + +D W++ +L
Sbjct: 261 SSVLWSDAEEIC---SASWDHTIRVWDVESGSL 290
Score = 37.0 bits (84), Expect = 0.041
Identities = 34/143 (23%), Positives = 63/143 (44%), Gaps = 10/143 (6%)
Query: 154 GHRDGIWDVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQL 213
GH + + V + + + +AS DHT +W +E+G G+ N I + P +
Sbjct: 255 GHMEAVSSVLWSDAEEIC--SASWDHTIRVWDVESGSLKSTLTGNK-VFNCISYSPLCKR 311
Query: 214 ALTASGDQTAHIWRYAVQLPTPQPVADTSISG-EDEVECSDKDEPDL-DGDVSS-----D 266
+ S D+ +W + + ++ TS +G V+ S E L G + + D
Sbjct: 312 LASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWD 371
Query: 267 CPTIRVPLTSLKSHQGVVIASDW 289
+ + PL L +H+ V++ DW
Sbjct: 372 TRSCKAPLYDLAAHEDKVLSVDW 394
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 87.8 bits (216), Expect = 2e-17
Identities = 76/278 (27%), Positives = 127/278 (45%), Gaps = 29/278 (10%)
Query: 131 SKIVSSFKTTT----SRAACQLVKEYIGHRDGIWDVSVAKTQPVVLGTASADHTALLWSI 186
++IVS T S + ++ +GH G+W ++ + ++ + S D T +W+
Sbjct: 274 NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWS---SQMRDNIIISGSTDRTLKVWNA 330
Query: 187 ETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLPTPQPVADTSISGE 246
ETG+C+ GH +V + H E+ ++ S D T +W + T Q + +
Sbjct: 331 ETGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVW----DIETGQCL-HVLMGHV 383
Query: 247 DEVECSDKDEPDL-----DGDVSSDCPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTASW 301
V C D + D V P L +L+ H V + + G V+ S
Sbjct: 384 AAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSL 441
Query: 302 DRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVN 361
D + ++DVET +H+LTGH Q LT ++V+ + D+T ++WD + + +
Sbjct: 442 DTSIRVWDVETGNCIHTLTGH-QSLT-SGMELKDNILVSGNADSTVKIWDIK--TGQCLQ 497
Query: 362 VFQG---HTDTVTSAVFTVGDNVVSGSDDRTVKVWDLK 396
QG H VT F + V++ SDD TVK+WDLK
Sbjct: 498 TLQGPNKHQSAVTCLQFN-KNFVITSSDDGTVKLWDLK 534
Score = 48.1 bits (113), Expect = 2e-05
Identities = 33/120 (27%), Positives = 57/120 (47%), Gaps = 6/120 (5%)
Query: 277 LKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQR 336
LK H VI G + V+ S D T ++ T + + +L GH + +
Sbjct: 258 LKGHDDHVITCLQFCGNR-IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV--WSSQMRDN 314
Query: 337 LVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDNVVSGSDDRTVKVWDLK 396
++++ S D T ++W+ + ++ GHT TV + VVSGS D T++VWD++
Sbjct: 315 IIISGSTDRTLKVWNAE--TGECIHTLYGHTSTV-RCMHLHEKRVVSGSRDATLRVWDIE 371
Score = 41.2 bits (95), Expect = 0.002
Identities = 20/50 (40%), Positives = 29/50 (58%), Gaps = 5/50 (10%)
Query: 344 DTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDNVVSGSDDRTVKVW 393
DT +R + + P V +GH D V + + G+ +VSGSDD T+KVW
Sbjct: 244 DTNWRRGELKSPK-----VLKGHDDHVITCLQFCGNRIVSGSDDNTLKVW 288
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 87.8 bits (216), Expect = 2e-17
Identities = 76/278 (27%), Positives = 127/278 (45%), Gaps = 29/278 (10%)
Query: 131 SKIVSSFKTTT----SRAACQLVKEYIGHRDGIWDVSVAKTQPVVLGTASADHTALLWSI 186
++IVS T S + ++ +GH G+W ++ + ++ + S D T +W+
Sbjct: 392 NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWS---SQMRDNIIISGSTDRTLKVWNA 448
Query: 187 ETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLPTPQPVADTSISGE 246
ETG+C+ GH +V + H E+ ++ S D T +W + T Q + +
Sbjct: 449 ETGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVW----DIETGQCL-HVLMGHV 501
Query: 247 DEVECSDKDEPDL-----DGDVSSDCPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTASW 301
V C D + D V P L +L+ H V + + G V+ S
Sbjct: 502 AAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSL 559
Query: 302 DRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVN 361
D + ++DVET +H+LTGH Q LT ++V+ + D+T ++WD + + +
Sbjct: 560 DTSIRVWDVETGNCIHTLTGH-QSLT-SGMELKDNILVSGNADSTVKIWDIK--TGQCLQ 615
Query: 362 VFQG---HTDTVTSAVFTVGDNVVSGSDDRTVKVWDLK 396
QG H VT F + V++ SDD TVK+WDLK
Sbjct: 616 TLQGPNKHQSAVTCLQFN-KNFVITSSDDGTVKLWDLK 652
Score = 48.1 bits (113), Expect = 2e-05
Identities = 33/120 (27%), Positives = 57/120 (47%), Gaps = 6/120 (5%)
Query: 277 LKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQR 336
LK H VI G + V+ S D T ++ T + + +L GH + +
Sbjct: 376 LKGHDDHVITCLQFCGNR-IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV--WSSQMRDN 432
Query: 337 LVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDNVVSGSDDRTVKVWDLK 396
++++ S D T ++W+ + ++ GHT TV + VVSGS D T++VWD++
Sbjct: 433 IIISGSTDRTLKVWNAE--TGECIHTLYGHTSTV-RCMHLHEKRVVSGSRDATLRVWDIE 489
Score = 41.2 bits (95), Expect = 0.002
Identities = 20/50 (40%), Positives = 29/50 (58%), Gaps = 5/50 (10%)
Query: 344 DTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDNVVSGSDDRTVKVW 393
DT +R + + P V +GH D V + + G+ +VSGSDD T+KVW
Sbjct: 362 DTNWRRGELKSPK-----VLKGHDDHVITCLQFCGNRIVSGSDDNTLKVW 406
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 87.8 bits (216), Expect = 2e-17
Identities = 76/278 (27%), Positives = 127/278 (45%), Gaps = 29/278 (10%)
Query: 131 SKIVSSFKTTT----SRAACQLVKEYIGHRDGIWDVSVAKTQPVVLGTASADHTALLWSI 186
++IVS T S + ++ +GH G+W ++ + ++ + S D T +W+
Sbjct: 312 NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWS---SQMRDNIIISGSTDRTLKVWNA 368
Query: 187 ETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLPTPQPVADTSISGE 246
ETG+C+ GH +V + H E+ ++ S D T +W + T Q + +
Sbjct: 369 ETGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVW----DIETGQCL-HVLMGHV 421
Query: 247 DEVECSDKDEPDL-----DGDVSSDCPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTASW 301
V C D + D V P L +L+ H V + + G V+ S
Sbjct: 422 AAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSL 479
Query: 302 DRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVN 361
D + ++DVET +H+LTGH Q LT ++V+ + D+T ++WD + + +
Sbjct: 480 DTSIRVWDVETGNCIHTLTGH-QSLT-SGMELKDNILVSGNADSTVKIWDIK--TGQCLQ 535
Query: 362 VFQG---HTDTVTSAVFTVGDNVVSGSDDRTVKVWDLK 396
QG H VT F + V++ SDD TVK+WDLK
Sbjct: 536 TLQGPNKHQSAVTCLQFN-KNFVITSSDDGTVKLWDLK 572
Score = 48.1 bits (113), Expect = 2e-05
Identities = 33/120 (27%), Positives = 57/120 (47%), Gaps = 6/120 (5%)
Query: 277 LKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQR 336
LK H VI G + V+ S D T ++ T + + +L GH + +
Sbjct: 296 LKGHDDHVITCLQFCGNR-IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV--WSSQMRDN 352
Query: 337 LVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDNVVSGSDDRTVKVWDLK 396
++++ S D T ++W+ + ++ GHT TV + VVSGS D T++VWD++
Sbjct: 353 IIISGSTDRTLKVWNAE--TGECIHTLYGHTSTV-RCMHLHEKRVVSGSRDATLRVWDIE 409
Score = 41.2 bits (95), Expect = 0.002
Identities = 20/50 (40%), Positives = 29/50 (58%), Gaps = 5/50 (10%)
Query: 344 DTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDNVVSGSDDRTVKVW 393
DT +R + + P V +GH D V + + G+ +VSGSDD T+KVW
Sbjct: 282 DTNWRRGELKSPK-----VLKGHDDHVITCLQFCGNRIVSGSDDNTLKVW 326
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 87.0 bits (214), Expect = 3e-17
Identities = 72/262 (27%), Positives = 117/262 (44%), Gaps = 20/262 (7%)
Query: 148 LVKEYIGHRDGIW--DVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSI 205
L + + GHRD + D S+ Q L + S D ++W ++ ++ GH +V +
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQ---LASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCV 67
Query: 206 KFHPSEQLALTASGDQTAHIWRYAVQLPTPQPVADTSISGEDEVECSDKDEPDLDGDVSS 265
F PS L + S D+T IW V+ + A T+ CSD +S
Sbjct: 68 NFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHF-CSDGQS----FVTAS 122
Query: 266 DCPTIRVPLT-------SLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHS 318
D T++V T SL H V + + G+ V+AS D+T L+D + E VHS
Sbjct: 123 DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 182
Query: 319 LTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVF-TV 377
H +T+ HP+ + + D T ++WD R + + +Q H+ V F
Sbjct: 183 YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRL--LQHYQLHSAAVNGLSFHPS 240
Query: 378 GDNVVSGSDDRTVKVWDLKNMR 399
G+ +++ S D T+K+ DL R
Sbjct: 241 GNYLITASSDSTLKILDLMEGR 262
Score = 50.1 bits (118), Expect = 5e-06
Identities = 46/182 (25%), Positives = 68/182 (37%), Gaps = 8/182 (4%)
Query: 174 TASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW----RYA 229
TAS D T +W+ K L + H+ V KF P +L ++AS D+T +W R
Sbjct: 120 TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC 179
Query: 230 VQLPTPQPVADTSISGEDEVECSDKDEPDLDGDVSS-DCPTIRVPLTSLKSHQGVVIASD 288
V T + C +D V D T R+ L + H V
Sbjct: 180 VHSYCEHGGFVTYVDFHPSGTCIAA--AGMDNTVKVWDVRTHRL-LQHYQLHSAAVNGLS 236
Query: 289 WLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFR 348
+ G +TAS D T + D+ L+++L GH T T + D
Sbjct: 237 FHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVM 296
Query: 349 LW 350
+W
Sbjct: 297 VW 298
Score = 33.1 bits (74), Expect = 0.59
Identities = 22/83 (26%), Positives = 37/83 (44%), Gaps = 3/83 (3%)
Query: 354 DPSIHSVNVFQGHTDTVTSAVFTVGDN-VVSGSDDRTVKVWDLKNMRSPIATIRTDSAIN 412
DPS+ F+GH D VT F++ + SGS D + VW +K A+
Sbjct: 8 DPSLE--RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT 65
Query: 413 RINVCVGQKIIALPHDNRQVRLF 435
+N ++A ++ VR++
Sbjct: 66 CVNFSPSGHLLASGSRDKTVRIW 88
Score = 30.8 bits (68), Expect = 3.0
Identities = 13/54 (24%), Positives = 25/54 (46%)
Query: 174 TASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWR 227
TAS+D T + + G+ L GH G ++ F + + + D+ +W+
Sbjct: 246 TASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 87.0 bits (214), Expect = 3e-17
Identities = 72/262 (27%), Positives = 117/262 (44%), Gaps = 20/262 (7%)
Query: 148 LVKEYIGHRDGIW--DVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSI 205
L + + GHRD + D S+ Q L + S D ++W ++ ++ GH +V +
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQ---LASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCV 67
Query: 206 KFHPSEQLALTASGDQTAHIWRYAVQLPTPQPVADTSISGEDEVECSDKDEPDLDGDVSS 265
F PS L + S D+T IW V+ + A T+ CSD +S
Sbjct: 68 NFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHF-CSDGQS----FVTAS 122
Query: 266 DCPTIRVPLT-------SLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHS 318
D T++V T SL H V + + G+ V+AS D+T L+D + E VHS
Sbjct: 123 DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 182
Query: 319 LTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVF-TV 377
H +T+ HP+ + + D T ++WD R + + +Q H+ V F
Sbjct: 183 YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRL--LQHYQLHSAAVNGLSFHPS 240
Query: 378 GDNVVSGSDDRTVKVWDLKNMR 399
G+ +++ S D T+K+ DL R
Sbjct: 241 GNYLITASSDSTLKILDLMEGR 262
Score = 50.1 bits (118), Expect = 5e-06
Identities = 46/182 (25%), Positives = 68/182 (37%), Gaps = 8/182 (4%)
Query: 174 TASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW----RYA 229
TAS D T +W+ K L + H+ V KF P +L ++AS D+T +W R
Sbjct: 120 TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC 179
Query: 230 VQLPTPQPVADTSISGEDEVECSDKDEPDLDGDVSS-DCPTIRVPLTSLKSHQGVVIASD 288
V T + C +D V D T R+ L + H V
Sbjct: 180 VHSYCEHGGFVTYVDFHPSGTCIAA--AGMDNTVKVWDVRTHRL-LQHYQLHSAAVNGLS 236
Query: 289 WLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFR 348
+ G +TAS D T + D+ L+++L GH T T + D
Sbjct: 237 FHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVM 296
Query: 349 LW 350
+W
Sbjct: 297 VW 298
Score = 33.1 bits (74), Expect = 0.59
Identities = 22/83 (26%), Positives = 37/83 (44%), Gaps = 3/83 (3%)
Query: 354 DPSIHSVNVFQGHTDTVTSAVFTVGDN-VVSGSDDRTVKVWDLKNMRSPIATIRTDSAIN 412
DPS+ F+GH D VT F++ + SGS D + VW +K A+
Sbjct: 8 DPSLE--RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT 65
Query: 413 RINVCVGQKIIALPHDNRQVRLF 435
+N ++A ++ VR++
Sbjct: 66 CVNFSPSGHLLASGSRDKTVRIW 88
Score = 31.2 bits (69), Expect = 2.3
Identities = 18/86 (20%), Positives = 35/86 (40%), Gaps = 9/86 (10%)
Query: 174 TASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWR------ 227
TAS+D T + + G+ L GH G ++ F + + + D+ +W+
Sbjct: 246 TASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIV 305
Query: 228 ---YAVQLPTPQPVADTSISGEDEVE 250
++P P +S+ EV+
Sbjct: 306 DHGEVTKVPRPPATLASSMGNLPEVD 331
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 86.7 bits (213), Expect = 5e-17
Identities = 84/294 (28%), Positives = 127/294 (43%), Gaps = 29/294 (9%)
Query: 126 YKASTSKIVSSFKTTTSRAAC-----QLVKEYIGHRDGIWDVSVAKTQPVVLGTASADHT 180
Y+A KI+ +T S C Q + G++ + Q +V G D+T
Sbjct: 232 YRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQY-DDQKIVSGLR--DNT 288
Query: 181 ALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW------RYAVQLPT 234
+W T +C GH GSV +++ E++ +T S D T +W +
Sbjct: 289 IKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTGEMLNTLIHH 346
Query: 235 PQPVADTSISGEDEVECSDKDEPDLDGDVSSDCPTIRVPLTSLKSHQGVVIASDWLVGGK 294
+ V + V CS KD D++S PT L H+ V D+ K
Sbjct: 347 CEAVLHLRFNNGMMVTCS-KDRSIAVWDMAS--PTDITLRRVLVGHRAAVNVVDF--DDK 401
Query: 295 QAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRD 354
V+AS DRT +++ T E V +L GH + + C RLVV+ S D T RLWD
Sbjct: 402 YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDNTIRLWDIEC 459
Query: 355 PSIHSVNVFQGHTDTVTSAVFTVGDNVVSGSDDRTVKVWDL---KNMRSPIATI 405
+ + V +GH + V F +VSG+ D +KVWDL + R+P T+
Sbjct: 460 GA--CLRVLEGHEELVRCIRFD-NKRIVSGAYDGKIKVWDLVAALDPRAPAGTL 510
Score = 41.6 bits (96), Expect = 0.002
Identities = 30/115 (26%), Positives = 51/115 (44%), Gaps = 9/115 (7%)
Query: 123 KTTYKASTSKIVSSFKTTTSRAACQLVKEYIGHRDGIWDVSVAKTQPVVLGTASADHTAL 182
K AS + + + T+T C+ V+ GH+ GI + + + ++ + S+D+T
Sbjct: 401 KYIVSASGDRTIKVWNTST----CEFVRTLNGHKRGI---ACLQYRDRLVVSGSSDNTIR 453
Query: 183 LWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLPTPQP 237
LW IE G CL GH V I+F + ++ + D +W L P
Sbjct: 454 LWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLVAALDPRAP 506
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 86.7 bits (213), Expect = 5e-17
Identities = 84/294 (28%), Positives = 127/294 (43%), Gaps = 29/294 (9%)
Query: 126 YKASTSKIVSSFKTTTSRAAC-----QLVKEYIGHRDGIWDVSVAKTQPVVLGTASADHT 180
Y+A KI+ +T S C Q + G++ + Q +V G D+T
Sbjct: 268 YRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQY-DDQKIVSGLR--DNT 324
Query: 181 ALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW------RYAVQLPT 234
+W T +C GH GSV +++ E++ +T S D T +W +
Sbjct: 325 IKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTGEMLNTLIHH 382
Query: 235 PQPVADTSISGEDEVECSDKDEPDLDGDVSSDCPTIRVPLTSLKSHQGVVIASDWLVGGK 294
+ V + V CS KD D++S PT L H+ V D+ K
Sbjct: 383 CEAVLHLRFNNGMMVTCS-KDRSIAVWDMAS--PTDITLRRVLVGHRAAVNVVDF--DDK 437
Query: 295 QAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRD 354
V+AS DRT +++ T E V +L GH + + C RLVV+ S D T RLWD
Sbjct: 438 YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDNTIRLWDIEC 495
Query: 355 PSIHSVNVFQGHTDTVTSAVFTVGDNVVSGSDDRTVKVWDL---KNMRSPIATI 405
+ + V +GH + V F +VSG+ D +KVWDL + R+P T+
Sbjct: 496 GA--CLRVLEGHEELVRCIRFD-NKRIVSGAYDGKIKVWDLVAALDPRAPAGTL 546
Score = 41.6 bits (96), Expect = 0.002
Identities = 30/115 (26%), Positives = 51/115 (44%), Gaps = 9/115 (7%)
Query: 123 KTTYKASTSKIVSSFKTTTSRAACQLVKEYIGHRDGIWDVSVAKTQPVVLGTASADHTAL 182
K AS + + + T+T C+ V+ GH+ GI + + + ++ + S+D+T
Sbjct: 437 KYIVSASGDRTIKVWNTST----CEFVRTLNGHKRGI---ACLQYRDRLVVSGSSDNTIR 489
Query: 183 LWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLPTPQP 237
LW IE G CL GH V I+F + ++ + D +W L P
Sbjct: 490 LWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLVAALDPRAP 542
>gi|148536855 coatomer protein complex, subunit alpha isoform 1
[Homo sapiens]
Length = 1233
Score = 86.3 bits (212), Expect = 6e-17
Identities = 64/266 (24%), Positives = 121/266 (45%), Gaps = 19/266 (7%)
Query: 146 CQLVKEYIGHRDGIWDVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSI 205
C L+ ++ H + + K QP+ + + D+ +W+ + +CL GH+ + +
Sbjct: 41 CTLIDKFDEHDGPVRGIDFHKQQPLFV-SGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTT 99
Query: 206 KFHPSEQLALTASGDQTAHIWRYAVQLPTPQPVADTSISGEDEVECSDKDEPDLDGDVSS 265
FH L+AS DQT +W + + ++G + + P D VS+
Sbjct: 100 FFHHEYPWILSASDDQTIRVWNWQSR------TCVCVLTGHNHYVMCAQFHPTEDLVVSA 153
Query: 266 DC-PTIRV-PLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHD 323
T+RV ++ L+ A + V G V +L+ + + H L GHD
Sbjct: 154 SLDQTVRVWDISGLRKKNLSPGAVESDVRGITGV--------DLFGTTDAVVKHVLEGHD 205
Query: 324 QELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDN-VV 382
+ + HPT L+V+ + D ++W + V+ +GH + V+ AVF ++
Sbjct: 206 RGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELIL 265
Query: 383 SGSDDRTVKVWDLKNMRSPIATIRTD 408
S S+D++++VWD+ + R+ + T R D
Sbjct: 266 SNSEDKSIRVWDM-SKRTGVQTFRRD 290
Score = 69.7 bits (169), Expect = 6e-12
Identities = 79/330 (23%), Positives = 127/330 (38%), Gaps = 88/330 (26%)
Query: 183 LWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLPTPQPVADTS 242
LW + K+ H G V I FH + L ++ D +W Y
Sbjct: 35 LWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYK------------- 81
Query: 243 ISGEDEVECSDKDEPDLDGDVSSDCPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTASWD 302
+R L +L H + + + ++AS D
Sbjct: 82 ---------------------------LRRCLFTLLGHLDYIRTTFFHHEYPWILSASDD 114
Query: 303 RTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRD-------- 354
+T +++ ++ V LTGH+ + HPT+ LVV++S D T R+WD
Sbjct: 115 QTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSP 174
Query: 355 -------PSIHSVNVFQGHTDTVTSAVFTVGDN-------------VVSGSDDRTVKVWD 394
I V++F G TD V V D +VSG+DDR VK+W
Sbjct: 175 GAVESDVRGITGVDLF-GTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWR 233
Query: 395 LKNMRS-PIATIRTDSAINRINVCV---GQKIIALPHDNRQVRLFDMS---GVRLARLPR 447
+ ++ + T R N ++ V Q++I +++ +R++DMS GV +
Sbjct: 234 MNESKAWEVDTCR--GHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGV------Q 285
Query: 448 SSRQGHRRMVCCSAWSEDHPVCNLFTCGFD 477
+ R+ H R +A HP NLF G D
Sbjct: 286 TFRRDHDRFWVLAA----HPNLNLFAAGHD 311
Score = 53.5 bits (127), Expect = 4e-07
Identities = 57/209 (27%), Positives = 88/209 (42%), Gaps = 25/209 (11%)
Query: 280 HQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVV 339
H G V D+ V+ D +++ + + +L GH + H ++
Sbjct: 50 HDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWIL 109
Query: 340 TSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVF-TVGDNVVSGSDDRTVKVWDLKNM 398
++S D T R+W+++ S V V GH V A F D VVS S D+TV+VWD+ +
Sbjct: 110 SASDDQTIRVWNWQ--SRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGL 167
Query: 399 RSPIATIRTDSAINRINVCVGQKIIALPHDNRQVRLFDMSGVRLARLPRSSRQGHRRMVC 458
R + N+ G A+ D R + D+ G A + + +GH R V
Sbjct: 168 R-------------KKNLSPG----AVESDVRGITGVDLFGTTDA-VVKHVLEGHDRGV- 208
Query: 459 CSAWSEDHPVCNLFTCGF-DRQAIGWNIN 486
W+ HP L G DRQ W +N
Sbjct: 209 --NWAAFHPTMPLIVSGADDRQVKIWRMN 235
Score = 37.0 bits (84), Expect = 0.041
Identities = 22/69 (31%), Positives = 35/69 (50%), Gaps = 3/69 (4%)
Query: 332 HPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDNV-VSGSDDRTV 390
HP + ++TS + +LWD+R ++ ++ F H V F + VSG DD +
Sbjct: 18 HPKRPWILTSLHNGVIQLWDYRMCTL--IDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKI 75
Query: 391 KVWDLKNMR 399
KVW+ K R
Sbjct: 76 KVWNYKLRR 84
>gi|148536853 coatomer protein complex, subunit alpha isoform 2
[Homo sapiens]
Length = 1224
Score = 86.3 bits (212), Expect = 6e-17
Identities = 64/266 (24%), Positives = 121/266 (45%), Gaps = 19/266 (7%)
Query: 146 CQLVKEYIGHRDGIWDVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSI 205
C L+ ++ H + + K QP+ + + D+ +W+ + +CL GH+ + +
Sbjct: 41 CTLIDKFDEHDGPVRGIDFHKQQPLFV-SGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTT 99
Query: 206 KFHPSEQLALTASGDQTAHIWRYAVQLPTPQPVADTSISGEDEVECSDKDEPDLDGDVSS 265
FH L+AS DQT +W + + ++G + + P D VS+
Sbjct: 100 FFHHEYPWILSASDDQTIRVWNWQSR------TCVCVLTGHNHYVMCAQFHPTEDLVVSA 153
Query: 266 DC-PTIRV-PLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHD 323
T+RV ++ L+ A + V G V +L+ + + H L GHD
Sbjct: 154 SLDQTVRVWDISGLRKKNLSPGAVESDVRGITGV--------DLFGTTDAVVKHVLEGHD 205
Query: 324 QELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDN-VV 382
+ + HPT L+V+ + D ++W + V+ +GH + V+ AVF ++
Sbjct: 206 RGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELIL 265
Query: 383 SGSDDRTVKVWDLKNMRSPIATIRTD 408
S S+D++++VWD+ + R+ + T R D
Sbjct: 266 SNSEDKSIRVWDM-SKRTGVQTFRRD 290
Score = 69.7 bits (169), Expect = 6e-12
Identities = 79/330 (23%), Positives = 127/330 (38%), Gaps = 88/330 (26%)
Query: 183 LWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLPTPQPVADTS 242
LW + K+ H G V I FH + L ++ D +W Y
Sbjct: 35 LWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYK------------- 81
Query: 243 ISGEDEVECSDKDEPDLDGDVSSDCPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTASWD 302
+R L +L H + + + ++AS D
Sbjct: 82 ---------------------------LRRCLFTLLGHLDYIRTTFFHHEYPWILSASDD 114
Query: 303 RTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRD-------- 354
+T +++ ++ V LTGH+ + HPT+ LVV++S D T R+WD
Sbjct: 115 QTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSP 174
Query: 355 -------PSIHSVNVFQGHTDTVTSAVFTVGDN-------------VVSGSDDRTVKVWD 394
I V++F G TD V V D +VSG+DDR VK+W
Sbjct: 175 GAVESDVRGITGVDLF-GTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWR 233
Query: 395 LKNMRS-PIATIRTDSAINRINVCV---GQKIIALPHDNRQVRLFDMS---GVRLARLPR 447
+ ++ + T R N ++ V Q++I +++ +R++DMS GV +
Sbjct: 234 MNESKAWEVDTCR--GHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGV------Q 285
Query: 448 SSRQGHRRMVCCSAWSEDHPVCNLFTCGFD 477
+ R+ H R +A HP NLF G D
Sbjct: 286 TFRRDHDRFWVLAA----HPNLNLFAAGHD 311
Score = 53.5 bits (127), Expect = 4e-07
Identities = 57/209 (27%), Positives = 88/209 (42%), Gaps = 25/209 (11%)
Query: 280 HQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVV 339
H G V D+ V+ D +++ + + +L GH + H ++
Sbjct: 50 HDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWIL 109
Query: 340 TSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVF-TVGDNVVSGSDDRTVKVWDLKNM 398
++S D T R+W+++ S V V GH V A F D VVS S D+TV+VWD+ +
Sbjct: 110 SASDDQTIRVWNWQ--SRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGL 167
Query: 399 RSPIATIRTDSAINRINVCVGQKIIALPHDNRQVRLFDMSGVRLARLPRSSRQGHRRMVC 458
R + N+ G A+ D R + D+ G A + + +GH R V
Sbjct: 168 R-------------KKNLSPG----AVESDVRGITGVDLFGTTDA-VVKHVLEGHDRGV- 208
Query: 459 CSAWSEDHPVCNLFTCGF-DRQAIGWNIN 486
W+ HP L G DRQ W +N
Sbjct: 209 --NWAAFHPTMPLIVSGADDRQVKIWRMN 235
Score = 37.0 bits (84), Expect = 0.041
Identities = 22/69 (31%), Positives = 35/69 (50%), Gaps = 3/69 (4%)
Query: 332 HPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDNV-VSGSDDRTV 390
HP + ++TS + +LWD+R ++ ++ F H V F + VSG DD +
Sbjct: 18 HPKRPWILTSLHNGVIQLWDYRMCTL--IDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKI 75
Query: 391 KVWDLKNMR 399
KVW+ K R
Sbjct: 76 KVWNYKLRR 84
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 85.9 bits (211), Expect = 8e-17
Identities = 72/238 (30%), Positives = 110/238 (46%), Gaps = 23/238 (9%)
Query: 178 DHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQ------ 231
D++ +W + +CL GH GSV +++ E++ +T S D T +W
Sbjct: 259 DNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVNTGEVLNTL 316
Query: 232 LPTPQPVADTSISGEDEVECSDKDEPDLDGDVSSDCP-TIRVPLTSLKSHQGVVIASDWL 290
+ + V S V CS KD D++S T+R L ++ VV D
Sbjct: 317 IHHNEAVLHLRFSNGLMVTCS-KDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDD-- 373
Query: 291 VGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLW 350
K V+AS DRT ++ T E V +L GH + + C RLVV+ S D T RLW
Sbjct: 374 ---KYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIA--CLQYRDRLVVSGSSDNTIRLW 428
Query: 351 DFRDPSIHSVNVFQGHTDTVTSAVFTVGDNVVSGSDDRTVKVWDLK---NMRSPIATI 405
D + + V +GH + V F +VSG+ D +KVWDL+ + R+P +T+
Sbjct: 429 DIECGAC--LRVLEGHEELVRCIRFD-NKRIVSGAYDGKIKVWDLQAALDPRAPASTL 483
Score = 60.1 bits (144), Expect = 5e-09
Identities = 52/189 (27%), Positives = 85/189 (44%), Gaps = 16/189 (8%)
Query: 274 LTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHP 333
L L H G V+ + + VT S D T ++DV T E++++L H++ + H
Sbjct: 273 LKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLH--LRF 328
Query: 334 TQRLVVTSSRDTTFRLWDFRDPS-IHSVNVFQGHTDTVTSAVFTVGDNVVSGSDDRTVKV 392
+ L+VT S+D + +WD + I V GH V F +VS S DRT+KV
Sbjct: 329 SNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFD-DKYIVSASGDRTIKV 387
Query: 393 WDLKNMRSPIATIRTDSAINRINVCV--GQKIIALPHDNRQVRLFDMSGVRLARLPRSSR 450
W S +RT + R C+ +++ + +RL+D+ R+
Sbjct: 388 WS----TSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRV----L 439
Query: 451 QGHRRMVCC 459
+GH +V C
Sbjct: 440 EGHEELVRC 448
Score = 41.6 bits (96), Expect = 0.002
Identities = 30/117 (25%), Positives = 52/117 (44%), Gaps = 9/117 (7%)
Query: 123 KTTYKASTSKIVSSFKTTTSRAACQLVKEYIGHRDGIWDVSVAKTQPVVLGTASADHTAL 182
K AS + + + T+T C+ V+ GH+ GI + + + ++ + S+D+T
Sbjct: 374 KYIVSASGDRTIKVWSTST----CEFVRTLNGHKRGI---ACLQYRDRLVVSGSSDNTIR 426
Query: 183 LWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLPTPQPVA 239
LW IE G CL GH V I+F + ++ + D +W L P +
Sbjct: 427 LWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQAALDPRAPAS 481
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 85.9 bits (211), Expect = 8e-17
Identities = 72/238 (30%), Positives = 110/238 (46%), Gaps = 23/238 (9%)
Query: 178 DHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQ------ 231
D++ +W + +CL GH GSV +++ E++ +T S D T +W
Sbjct: 225 DNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVNTGEVLNTL 282
Query: 232 LPTPQPVADTSISGEDEVECSDKDEPDLDGDVSSDCP-TIRVPLTSLKSHQGVVIASDWL 290
+ + V S V CS KD D++S T+R L ++ VV D
Sbjct: 283 IHHNEAVLHLRFSNGLMVTCS-KDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDD-- 339
Query: 291 VGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLW 350
K V+AS DRT ++ T E V +L GH + + C RLVV+ S D T RLW
Sbjct: 340 ---KYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIA--CLQYRDRLVVSGSSDNTIRLW 394
Query: 351 DFRDPSIHSVNVFQGHTDTVTSAVFTVGDNVVSGSDDRTVKVWDLK---NMRSPIATI 405
D + + V +GH + V F +VSG+ D +KVWDL+ + R+P +T+
Sbjct: 395 DIECGAC--LRVLEGHEELVRCIRFD-NKRIVSGAYDGKIKVWDLQAALDPRAPASTL 449
Score = 60.1 bits (144), Expect = 5e-09
Identities = 52/189 (27%), Positives = 85/189 (44%), Gaps = 16/189 (8%)
Query: 274 LTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHP 333
L L H G V+ + + VT S D T ++DV T E++++L H++ + H
Sbjct: 239 LKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLH--LRF 294
Query: 334 TQRLVVTSSRDTTFRLWDFRDPS-IHSVNVFQGHTDTVTSAVFTVGDNVVSGSDDRTVKV 392
+ L+VT S+D + +WD + I V GH V F +VS S DRT+KV
Sbjct: 295 SNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFD-DKYIVSASGDRTIKV 353
Query: 393 WDLKNMRSPIATIRTDSAINRINVCV--GQKIIALPHDNRQVRLFDMSGVRLARLPRSSR 450
W S +RT + R C+ +++ + +RL+D+ R+
Sbjct: 354 WS----TSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRV----L 405
Query: 451 QGHRRMVCC 459
+GH +V C
Sbjct: 406 EGHEELVRC 414
Score = 41.6 bits (96), Expect = 0.002
Identities = 30/117 (25%), Positives = 52/117 (44%), Gaps = 9/117 (7%)
Query: 123 KTTYKASTSKIVSSFKTTTSRAACQLVKEYIGHRDGIWDVSVAKTQPVVLGTASADHTAL 182
K AS + + + T+T C+ V+ GH+ GI + + + ++ + S+D+T
Sbjct: 340 KYIVSASGDRTIKVWSTST----CEFVRTLNGHKRGI---ACLQYRDRLVVSGSSDNTIR 392
Query: 183 LWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLPTPQPVA 239
LW IE G CL GH V I+F + ++ + D +W L P +
Sbjct: 393 LWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQAALDPRAPAS 447
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 85.9 bits (211), Expect = 8e-17
Identities = 72/238 (30%), Positives = 110/238 (46%), Gaps = 23/238 (9%)
Query: 178 DHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQ------ 231
D++ +W + +CL GH GSV +++ E++ +T S D T +W
Sbjct: 246 DNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVNTGEVLNTL 303
Query: 232 LPTPQPVADTSISGEDEVECSDKDEPDLDGDVSSDCP-TIRVPLTSLKSHQGVVIASDWL 290
+ + V S V CS KD D++S T+R L ++ VV D
Sbjct: 304 IHHNEAVLHLRFSNGLMVTCS-KDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDD-- 360
Query: 291 VGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLW 350
K V+AS DRT ++ T E V +L GH + + C RLVV+ S D T RLW
Sbjct: 361 ---KYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIA--CLQYRDRLVVSGSSDNTIRLW 415
Query: 351 DFRDPSIHSVNVFQGHTDTVTSAVFTVGDNVVSGSDDRTVKVWDLK---NMRSPIATI 405
D + + V +GH + V F +VSG+ D +KVWDL+ + R+P +T+
Sbjct: 416 DIECGAC--LRVLEGHEELVRCIRFD-NKRIVSGAYDGKIKVWDLQAALDPRAPASTL 470
Score = 60.1 bits (144), Expect = 5e-09
Identities = 52/189 (27%), Positives = 85/189 (44%), Gaps = 16/189 (8%)
Query: 274 LTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHP 333
L L H G V+ + + VT S D T ++DV T E++++L H++ + H
Sbjct: 260 LKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLH--LRF 315
Query: 334 TQRLVVTSSRDTTFRLWDFRDPS-IHSVNVFQGHTDTVTSAVFTVGDNVVSGSDDRTVKV 392
+ L+VT S+D + +WD + I V GH V F +VS S DRT+KV
Sbjct: 316 SNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFD-DKYIVSASGDRTIKV 374
Query: 393 WDLKNMRSPIATIRTDSAINRINVCV--GQKIIALPHDNRQVRLFDMSGVRLARLPRSSR 450
W S +RT + R C+ +++ + +RL+D+ R+
Sbjct: 375 WS----TSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRV----L 426
Query: 451 QGHRRMVCC 459
+GH +V C
Sbjct: 427 EGHEELVRC 435
Score = 41.6 bits (96), Expect = 0.002
Identities = 30/117 (25%), Positives = 52/117 (44%), Gaps = 9/117 (7%)
Query: 123 KTTYKASTSKIVSSFKTTTSRAACQLVKEYIGHRDGIWDVSVAKTQPVVLGTASADHTAL 182
K AS + + + T+T C+ V+ GH+ GI + + + ++ + S+D+T
Sbjct: 361 KYIVSASGDRTIKVWSTST----CEFVRTLNGHKRGI---ACLQYRDRLVVSGSSDNTIR 413
Query: 183 LWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLPTPQPVA 239
LW IE G CL GH V I+F + ++ + D +W L P +
Sbjct: 414 LWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQAALDPRAPAS 468
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 84.0 bits (206), Expect = 3e-16
Identities = 71/278 (25%), Positives = 118/278 (42%), Gaps = 50/278 (17%)
Query: 154 GHRDGIWDVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQL 213
GH D + D+S + + L + SAD T LW + +C+ GH +V+S+ P+
Sbjct: 148 GHTDSVQDISFDHSGKL-LASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDH 206
Query: 214 ALTASGDQTAHIWR----YAVQLPTPQPVADTSISGEDEVECSDKDEPDLDGDVSSDCP- 268
++AS D+T +W Y V+ T E P+ DG + + C
Sbjct: 207 IVSASRDKTIKMWEVQTGYCVKTFTGHR------------EWVRMVRPNQDGTLIASCSN 254
Query: 269 --TIRVPLTS-------LKSHQGVVIASDWLVG--------------------GKQAVTA 299
T+RV + + L+ H+ VV W G ++
Sbjct: 255 DQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSG 314
Query: 300 SWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHS 359
S D+T ++DV T + +L GHD + H + +++ + D T R+WD+++
Sbjct: 315 SRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNK--RC 372
Query: 360 VNVFQGHTDTVTSAVF-TVGDNVVSGSDDRTVKVWDLK 396
+ H VTS F VV+GS D+TVKVW+ +
Sbjct: 373 MKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
Score = 68.9 bits (167), Expect = 1e-11
Identities = 68/308 (22%), Positives = 117/308 (37%), Gaps = 62/308 (20%)
Query: 154 GHRDGIWDVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQL 213
GHR + V V++ +AS D T +W ETG GH SV I F S +L
Sbjct: 106 GHRSPVTRVIFHPVFSVMV-SASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKL 164
Query: 214 ALTASGDQTAHIWRYAVQLPTPQPVADTSISGEDEVECSDKDEPDLDGDVSSDCPTIRVP 273
+ S D T +W + EC
Sbjct: 165 LASCSADMTIKLWDF------------------QGFEC---------------------- 184
Query: 274 LTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHP 333
+ ++ H V + + G V+AS D+T +++V+T V + TGH + + +
Sbjct: 185 IRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQ 244
Query: 334 TQRLVVTSSRDTTFRLW---------DFRDPSIHSVNVFQGHTDTVTSAVFTV------- 377
L+ + S D T R+W + R+ H V ++ S++
Sbjct: 245 DGTLIASCSNDQTVRVWVVATKECKAELREHE-HVVECISWAPESSYSSISEATGSETKK 303
Query: 378 ----GDNVVSGSDDRTVKVWDLKNMRSPIATIRTDSAINRINVCVGQKIIALPHDNRQVR 433
G ++SGS D+T+K+WD+ + + D+ + + G K I D++ +R
Sbjct: 304 SGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLR 363
Query: 434 LFDMSGVR 441
++D R
Sbjct: 364 VWDYKNKR 371
Score = 65.1 bits (157), Expect = 1e-10
Identities = 53/229 (23%), Positives = 96/229 (41%), Gaps = 23/229 (10%)
Query: 147 QLVKEYIGHRDGIWDVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIK 206
+ ++ GH + V++ ++ +AS D T +W ++TG C+ + GH V ++
Sbjct: 183 ECIRTMHGHDHNVSSVAIMPNGDHIV-SASRDKTIKMWEVQTGYCVKTFTGHREWVRMVR 241
Query: 207 FHPSEQLALTASGDQTAHIW--------------RYAVQLPTPQPVADTSISGE---DEV 249
+ L + S DQT +W + V+ + P + S E E
Sbjct: 242 PNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSET 301
Query: 250 ECSDKDEPDL-----DGDVSSDCPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTASWDRT 304
+ S K P L D + + + L +L H V + GGK ++ + D+T
Sbjct: 302 KKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKT 361
Query: 305 ANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFR 353
++D + + +L H+ +T H T VVT S D T ++W+ R
Sbjct: 362 LRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
Score = 52.0 bits (123), Expect = 1e-06
Identities = 26/81 (32%), Positives = 43/81 (53%), Gaps = 3/81 (3%)
Query: 317 HSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFT 376
++L+GH +T HP ++V++S D T ++WD+ +GHTD+V F
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFE--RTLKGHTDSVQDISFD 159
Query: 377 -VGDNVVSGSDDRTVKVWDLK 396
G + S S D T+K+WD +
Sbjct: 160 HSGKLLASCSADMTIKLWDFQ 180
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 82.0 bits (201), Expect = 1e-15
Identities = 58/245 (23%), Positives = 95/245 (38%), Gaps = 43/245 (17%)
Query: 151 EYIGHRDGIWDVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPS 210
++ G G + S +L T S D W +G+ L + GH G V +F P
Sbjct: 15 KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD 74
Query: 211 EQLALTASGDQTAHIWRYAVQLPTPQPVADTSISGEDEVECSDKDEPDLDGDVSSDCPTI 270
L +AS D T +W A +C
Sbjct: 75 GHLFASASCDCTVRLWDVA------------------RAKC------------------- 97
Query: 271 RVPLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCC 330
L LK HQ V + +Q + WD+ L+DV++ +++ L GH +
Sbjct: 98 ---LRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSD 154
Query: 331 THPTQRLVVTSSRDTTFRLWDFR--DPSIHSVNVFQGHTDTVTSAVFTVGDNVVSGSDDR 388
PT + T S D+T +WD R P++ S +GH+ ++ ++ + SGS D+
Sbjct: 155 FSPTVNCLATGSWDSTVHIWDLRMVTPAV-SHQALEGHSANISCLCYSASGLLASGSWDK 213
Query: 389 TVKVW 393
T+ +W
Sbjct: 214 TIHIW 218
Score = 59.7 bits (143), Expect = 6e-09
Identities = 59/249 (23%), Positives = 97/249 (38%), Gaps = 44/249 (17%)
Query: 142 SRAACQLVKEYIGHRDGIWDVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGS 201
+RA C V + GH+ + VS + L + D +LW +++G+ L GH S
Sbjct: 93 ARAKCLRVLK--GHQRSVETVSFSPDSRQ-LASGGWDKRVMLWDVQSGQMLRLLVGHRDS 149
Query: 202 VNSIKFHPSEQLALTASGDQTAHIWRYAVQLPTPQPVADTSISGEDEVECSDKDEPDLDG 261
+ S F P+ T S D T HIW + P V+ ++ G
Sbjct: 150 IQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPA---VSHQALEGH-------------SA 193
Query: 262 DVSSDCPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTG 321
++S C + AS L G SWD+T +++ TS L+ L G
Sbjct: 194 NISCLCYS----------------ASGLLASG------SWDKTIHIWKPTTSSLLIQLKG 231
Query: 322 HDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTV-GDN 380
H + P + + ++ ++WD + +G D + FT G
Sbjct: 232 HVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGK--CLETLKGVLDVAHTCAFTPDGKI 289
Query: 381 VVSGSDDRT 389
+VSG+ D+T
Sbjct: 290 LVSGAADQT 298
Score = 58.2 bits (139), Expect = 2e-08
Identities = 54/206 (26%), Positives = 81/206 (39%), Gaps = 44/206 (21%)
Query: 193 VKYAG-HVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLPTPQPVADTSISGEDEVEC 251
VK+ G H G VNS F P Q+ LT S D + W + SG+
Sbjct: 14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWE--------------TRSGQ----- 54
Query: 252 SDKDEPDLDGDVSSDCPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVE 311
L L H G V + G +AS D T L+DV
Sbjct: 55 ---------------------LLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVA 93
Query: 312 TSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVT 371
++ + L GH + + P R + + D LWD + + + + GH D++
Sbjct: 94 RAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM--LRLLVGHRDSIQ 151
Query: 372 SAVFTVGDN-VVSGSDDRTVKVWDLK 396
S+ F+ N + +GS D TV +WDL+
Sbjct: 152 SSDFSPTVNCLATGSWDSTVHIWDLR 177
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 81.3 bits (199), Expect = 2e-15
Identities = 78/325 (24%), Positives = 118/325 (36%), Gaps = 49/325 (15%)
Query: 98 DGAELSKGQLKTKASHSTSQLSQKLKTTYKASTSKIVSS-----FKTTTSRAACQLVKEY 152
D + L G S +KL++ +AS ++ + +K
Sbjct: 480 DDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKIL 539
Query: 153 IGHRDGIWDVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQ 212
GH ++ S + + +L ++S D T LWS++T CLV Y GH V +F P
Sbjct: 540 YGHSGPVYGASFSPDRNYLL-SSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 598
Query: 213 LALTASGDQTAHIWRYAVQLPTPQPVADTSISGEDEVECSDKDEPDLDGDVSSDCPTIRV 272
++ D+ A +W D +
Sbjct: 599 YFVSGGHDRVARLW------------------ATDHYQ---------------------- 618
Query: 273 PLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTH 332
PL H V + + T S DRT L+DV V TGH +
Sbjct: 619 PLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFS 678
Query: 333 PTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTV-GDNVVSGSDDRTVK 391
P R + T + D LWD + V +GHTDTV S F+ G+ + SGS D TV+
Sbjct: 679 PNGRFLATGATDGRVLLWDIGHGLM--VGELKGHTDTVCSLRFSRDGEILASGSMDNTVR 736
Query: 392 VWDLKNMRSPIATIRTDSAINRINV 416
+WD + T +A IN+
Sbjct: 737 LWDAIKAFEDLETDDFTTATGHINL 761
Score = 57.0 bits (136), Expect = 4e-08
Identities = 60/262 (22%), Positives = 105/262 (40%), Gaps = 24/262 (9%)
Query: 210 SEQLALTASG--DQTAHIWRYAVQLPTPQPVADTSISGEDEVECSDKDEPDLDGDVSSDC 267
++ +L A G D T +W TP+ + S+ ++ DK+ D+ + +
Sbjct: 479 TDDSSLIAGGFADSTVRVWSV-----TPKKLR--SVKQASDLSLIDKESDDVLERIMDEK 531
Query: 268 PTIRVPLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELT 327
+ + L H G V + + +++S D T L+ ++T + GH+ +
Sbjct: 532 TASELKI--LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVW 589
Query: 328 HCCTHPTQRLVVTSSRDTTFRLW--DFRDPSIHSVNVFQGHTDTVTSAVFTVGDN-VVSG 384
P V+ D RLW D P + +F GH V F N V +G
Sbjct: 590 DTQFSPYGYYFVSGGHDRVARLWATDHYQP----LRIFAGHLADVNCTRFHPNSNYVATG 645
Query: 385 SDDRTVKVWDLKNMRSPIATIRTDSAINRINVCVGQKIIALPHDNRQVRLFDMS-GVRLA 443
S DRTV++WD+ N I+ + + +A + +V L+D+ G+ +
Sbjct: 646 SADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVG 705
Query: 444 RLPRSSRQGHRRMVCCSAWSED 465
L +GH VC +S D
Sbjct: 706 EL-----KGHTDTVCSLRFSRD 722
Score = 55.1 bits (131), Expect = 1e-07
Identities = 57/246 (23%), Positives = 96/246 (39%), Gaps = 15/246 (6%)
Query: 152 YIGHRDGIWDVSVAKTQPVVLGTASADHTALLWSIETGKCL-VKYAGHVGSVNSIKFHPS 210
++ G+ V V ++ G AD T +WS+ K VK A + ++
Sbjct: 466 FLNAYQGLTAVDVTDDSSLIAG-GFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVL 524
Query: 211 EQLALTASGDQTAHIWRYAVQLPTPQPVADTSISGEDEVECSDKDEPDLDGDVSSDCPTI 270
E++ + + ++ ++ PV S S + S + DG V
Sbjct: 525 ERIMDEKTASELKILYGHS------GPVYGASFSPDRNYLLSSSE----DGTVRLWSLQT 574
Query: 271 RVPLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCC 330
L K H V + + G V+ DR A L+ + + + GH ++
Sbjct: 575 FTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTR 634
Query: 331 THPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTV-GDNVVSGSDDRT 389
HP V T S D T RLWD + + V +F GH + S F+ G + +G+ D
Sbjct: 635 FHPNSNYVATGSADRTVRLWDVLNG--NCVRIFTGHKGPIHSLTFSPNGRFLATGATDGR 692
Query: 390 VKVWDL 395
V +WD+
Sbjct: 693 VLLWDI 698
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 80.1 bits (196), Expect = 4e-15
Identities = 57/233 (24%), Positives = 91/233 (39%), Gaps = 50/233 (21%)
Query: 152 YIGHRDGIWDVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSE 211
Y GH +WD+ ++ + + S D TA LWS + L YAGH+ V+ +KFHP+
Sbjct: 380 YQGHAYPVWDLDISPYS-LYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNS 438
Query: 212 QLALTASGDQTAHIWRYAVQLPTPQPVADTSISGEDEVECSDKDEPDLDGDVSSDCPTIR 271
T S D+T +W + ++R
Sbjct: 439 NYLATGSTDKTVRLWS------------------------------------AQQGNSVR 462
Query: 272 VPLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCT 331
+ H+G V++ + GK +A D+ L+D+ + L L GH +T
Sbjct: 463 L----FTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTF 518
Query: 332 HPTQRLVVTSSRDTTFRLWDFRD---------PSIHSVNVFQGHTDTVTSAVF 375
P L+ ++S D + R+WD R+ S V V+ G V S F
Sbjct: 519 SPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNVLSVQF 571
Score = 61.2 bits (147), Expect = 2e-09
Identities = 53/208 (25%), Positives = 79/208 (37%), Gaps = 13/208 (6%)
Query: 197 GHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLPT------PQPVADTSISGEDEVE 250
GH G V S +F L+ S D + W T PV D IS
Sbjct: 340 GHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYF 399
Query: 251 CSDKDEPDLDGDVSSDCPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDV 310
S D + S T PL H V + T S D+T L+
Sbjct: 400 ASGSH--DRTARLWSFDRTY--PLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSA 455
Query: 311 ETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTV 370
+ V TGH + P + + ++ D +LWD +++ +GHTD +
Sbjct: 456 QQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLY--KELRGHTDNI 513
Query: 371 TSAVFTVGDNVV-SGSDDRTVKVWDLKN 397
TS F+ ++ S S D +V+VWD++N
Sbjct: 514 TSLTFSPDSGLIASASMDNSVRVWDIRN 541
Score = 47.4 bits (111), Expect = 3e-05
Identities = 42/210 (20%), Positives = 84/210 (40%), Gaps = 9/210 (4%)
Query: 277 LKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQR 336
L+ H G V ++ +L ++ S D + +D+ + GH + P
Sbjct: 338 LRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSL 397
Query: 337 LVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDN-VVSGSDDRTVKVWDL 395
+ S D T RLW F + + ++ GH V F N + +GS D+TV++W
Sbjct: 398 YFASGSHDRTARLWSF--DRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSA 455
Query: 396 KNMRSPIATIRTDSAINRINVCVGQKIIALPHDNRQVRLFDMSGVRLARLPRSSRQGHRR 455
+ S + + K +A ++++++L+D++ L + +GH
Sbjct: 456 QQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYK----ELRGHTD 511
Query: 456 MVCCSAWSEDHPVCNLFTCGFDRQAIGWNI 485
+ +S D + + + D W+I
Sbjct: 512 NITSLTFSPDSGL--IASASMDNSVRVWDI 539
Score = 41.2 bits (95), Expect = 0.002
Identities = 20/78 (25%), Positives = 36/78 (46%), Gaps = 1/78 (1%)
Query: 149 VKEYIGHRDGIWDVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFH 208
V+ + GHR + ++ + L +A D LW + +G + GH ++ S+ F
Sbjct: 461 VRLFTGHRGPVLSLAFSPNGKY-LASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFS 519
Query: 209 PSEQLALTASGDQTAHIW 226
P L +AS D + +W
Sbjct: 520 PDSGLIASASMDNSVRVW 537
>gi|4757988 WD repeat domain 39 [Homo sapiens]
Length = 339
Score = 78.6 bits (192), Expect = 1e-14
Identities = 80/346 (23%), Positives = 127/346 (36%), Gaps = 67/346 (19%)
Query: 171 VLGTASADHTALLWSIETGKCLVKYA---GHVGSVNSIKFHPSEQLALTASGDQTAHIWR 227
+L + D +W E + K GH +V + + P +AS D T IW+
Sbjct: 30 LLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWK 89
Query: 228 YAVQLPTPQPVADTSISGEDEVECSDKDEPDLDGDVSSDCPTIRVPLTSLKSHQGVVIAS 287
+D+ EC +T+L+ H+ V +
Sbjct: 90 ----------------KNQDDFEC----------------------VTTLEGHENEVKSV 111
Query: 288 DWLVGGKQAVTASWDRTANLYDVETS---ELVHSLTGHDQELTHCCTHPTQRLVVTSSRD 344
W G T S D++ +++V+ E V L H Q++ H HP+Q L+ ++S D
Sbjct: 112 AWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYD 171
Query: 345 TTFRLWDFRDPSIHSVNVFQGHTDTVTSAVF-TVGDNVVSGSDDRTVKVWD--LKNMRSP 401
T +L+ + +GH TV S F G + S SDDRTV++W L
Sbjct: 172 DTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQG 231
Query: 402 IATIRTDSA--------------INRINVCVGQKIIALPHDNRQVRLFDMSGVRLARLPR 447
+A +D + I I C +A + +R+F + P
Sbjct: 232 VACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPT 291
Query: 448 SS-----RQGHRRMVCCSAWSEDHPVCNLFTCGFDRQAIGWNINIP 488
S Q H + V C AW+ P L +C D + W P
Sbjct: 292 FSLTAHLHQAHSQDVNCVAWNPKEPGL-LASCSDDGEVAFWKYQRP 336
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 77.8 bits (190), Expect = 2e-14
Identities = 80/321 (24%), Positives = 136/321 (42%), Gaps = 44/321 (13%)
Query: 109 TKASHSTSQLSQKLKTTYK-----ASTSKIVSSFKTT------TSRAACQLVKEY----- 152
T +S +T +K Y A +K VSS K + S +A +L+K +
Sbjct: 18 TPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG 77
Query: 153 ------IGHRDGIWDVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIK 206
GH+ GI DV+ + +++ +AS D T +W + +GKCL GH V
Sbjct: 78 KFEKTISGHKLGISDVAWSSDSNLLV-SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCN 136
Query: 207 FHPSEQLALTASGDQTAHIW-----RYAVQLPT-PQPVADTSISGEDEVECSDKDEPDLD 260
F+P L ++ S D++ IW + LP PV+ + + + S D
Sbjct: 137 FNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSS----SYD 192
Query: 261 GDVSS-DCPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSL 319
G D + + T + V + GK + A+ D T L+D + + +
Sbjct: 193 GLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252
Query: 320 TGHDQELTHCC----THPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVF 375
TGH E +C + + +V+ S D +W+ + I V QGHTD V S
Sbjct: 253 TGHKNE-KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI--VQKLQGHTDVVISTAC 309
Query: 376 TVGDNVVSGS---DDRTVKVW 393
+N+++ + +D+T+K+W
Sbjct: 310 HPTENIIASAALENDKTIKLW 330
Score = 62.0 bits (149), Expect = 1e-09
Identities = 49/207 (23%), Positives = 93/207 (44%), Gaps = 14/207 (6%)
Query: 196 AGHVGSVNSIKFHPSEQLALTASGDQTAHIW-----RYAVQLPTPQ-PVADTSISGEDEV 249
AGH +V+S+KF P+ + ++S D+ IW ++ + + ++D + S + +
Sbjct: 42 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 101
Query: 250 ECSDKDEPDLD-GDVSSD-CPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANL 307
S D+ L DVSS C L +LK H V ++ V+ S+D + +
Sbjct: 102 LVSASDDKTLKIWDVSSGKC------LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 155
Query: 308 YDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHT 367
+DV+T + + +L H ++ + L+V+SS D R+WD + +
Sbjct: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP 215
Query: 368 DTVTSAVFTVGDNVVSGSDDRTVKVWD 394
G +++ + D T+K+WD
Sbjct: 216 PVSFVKFSPNGKYILAATLDNTLKLWD 242
Score = 53.9 bits (128), Expect = 3e-07
Identities = 64/315 (20%), Positives = 126/315 (40%), Gaps = 58/315 (18%)
Query: 50 LPSSVRSTLLELFGQIEREFEN------LYIENLELRREIDTLNERLAAEGQAIDGAELS 103
L SS L++++G + +FE L I ++ + + L A++ + + ++S
Sbjct: 60 LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVS--ASDDKTLKIWDVS 117
Query: 104 KGQ-LKTKASHST----SQLSQKLKTTYKASTSKIVSSFKTTTSRAACQLVKEYIGHRDG 158
G+ LKT HS + + S + V + T + +K H D
Sbjct: 118 SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC----LKTLPAHSDP 173
Query: 159 IWDVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGS-VNSIKFHPSEQLALTA 217
+ V + +++ ++S D +W +G+CL V+ +KF P+ + L A
Sbjct: 174 VSAVHFNRDGSLIV-SSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAA 232
Query: 218 SGDQTAHIWRYAVQLPTPQPVADTSISGEDEVECSDKDEPDLDGDVSSDCPTIRVPLTSL 277
+ D T +W Y+ + +C T
Sbjct: 233 TLDNTLKLWDYS------------------KGKCLK-------------------TYTGH 255
Query: 278 KSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRL 337
K+ + + A+ + GGK V+ S D +++++T E+V L GH + HPT+ +
Sbjct: 256 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENI 315
Query: 338 VVTSS--RDTTFRLW 350
+ +++ D T +LW
Sbjct: 316 IASAALENDKTIKLW 330
Score = 50.8 bits (120), Expect = 3e-06
Identities = 30/122 (24%), Positives = 59/122 (48%), Gaps = 3/122 (2%)
Query: 276 SLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQ 335
+L H V + + G+ ++S D+ ++ + +++GH ++
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 336 RLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDN-VVSGSDDRTVKVWD 394
L+V++S D T ++WD S + +GH++ V F N +VSGS D +V++WD
Sbjct: 100 NLLVSASDDKTLKIWDV--SSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
Query: 395 LK 396
+K
Sbjct: 158 VK 159
Score = 41.2 bits (95), Expect = 0.002
Identities = 35/140 (25%), Positives = 64/140 (45%), Gaps = 10/140 (7%)
Query: 315 LVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAV 374
L +L GH + ++ P + +SS D ++W D GH ++
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT--ISGHKLGISDVA 94
Query: 375 FTVGDNV-VSGSDDRTVKVWDLKNMRSPIATIRTDSAINRINVC---VGQKIIALPHDNR 430
++ N+ VS SDD+T+K+WD+ + + + T++ S N + C +I +
Sbjct: 95 WSSDSNLLVSASDDKTLKIWDVSSGKC-LKTLKGHS--NYVFCCNFNPQSNLIVSGSFDE 151
Query: 431 QVRLFDM-SGVRLARLPRSS 449
VR++D+ +G L LP S
Sbjct: 152 SVRIWDVKTGKCLKTLPAHS 171
Score = 40.0 bits (92), Expect = 0.005
Identities = 26/92 (28%), Positives = 48/92 (52%), Gaps = 10/92 (10%)
Query: 142 SRAACQLVKEYIGHRDGIWDV----SVAKTQPVVLGTASADHTALLWSIETGKCLVKYAG 197
S+ C +K Y GH++ + + SV + +V G S D+ +W+++T + + K G
Sbjct: 244 SKGKC--LKTYTGHKNEKYCIFANFSVTGGKWIVSG--SEDNLVYIWNLQTKEIVQKLQG 299
Query: 198 HVGSVNSIKFHPSEQLALTAS--GDQTAHIWR 227
H V S HP+E + +A+ D+T +W+
Sbjct: 300 HTDVVISTACHPTENIIASAALENDKTIKLWK 331
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 77.8 bits (190), Expect = 2e-14
Identities = 80/321 (24%), Positives = 136/321 (42%), Gaps = 44/321 (13%)
Query: 109 TKASHSTSQLSQKLKTTYK-----ASTSKIVSSFKTT------TSRAACQLVKEY----- 152
T +S +T +K Y A +K VSS K + S +A +L+K +
Sbjct: 18 TPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG 77
Query: 153 ------IGHRDGIWDVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIK 206
GH+ GI DV+ + +++ +AS D T +W + +GKCL GH V
Sbjct: 78 KFEKTISGHKLGISDVAWSSDSNLLV-SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCN 136
Query: 207 FHPSEQLALTASGDQTAHIW-----RYAVQLPT-PQPVADTSISGEDEVECSDKDEPDLD 260
F+P L ++ S D++ IW + LP PV+ + + + S D
Sbjct: 137 FNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSS----SYD 192
Query: 261 GDVSS-DCPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSL 319
G D + + T + V + GK + A+ D T L+D + + +
Sbjct: 193 GLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252
Query: 320 TGHDQELTHCC----THPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVF 375
TGH E +C + + +V+ S D +W+ + I V QGHTD V S
Sbjct: 253 TGHKNE-KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI--VQKLQGHTDVVISTAC 309
Query: 376 TVGDNVVSGS---DDRTVKVW 393
+N+++ + +D+T+K+W
Sbjct: 310 HPTENIIASAALENDKTIKLW 330
Score = 62.0 bits (149), Expect = 1e-09
Identities = 49/207 (23%), Positives = 93/207 (44%), Gaps = 14/207 (6%)
Query: 196 AGHVGSVNSIKFHPSEQLALTASGDQTAHIW-----RYAVQLPTPQ-PVADTSISGEDEV 249
AGH +V+S+KF P+ + ++S D+ IW ++ + + ++D + S + +
Sbjct: 42 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 101
Query: 250 ECSDKDEPDLD-GDVSSD-CPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANL 307
S D+ L DVSS C L +LK H V ++ V+ S+D + +
Sbjct: 102 LVSASDDKTLKIWDVSSGKC------LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 155
Query: 308 YDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHT 367
+DV+T + + +L H ++ + L+V+SS D R+WD + +
Sbjct: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP 215
Query: 368 DTVTSAVFTVGDNVVSGSDDRTVKVWD 394
G +++ + D T+K+WD
Sbjct: 216 PVSFVKFSPNGKYILAATLDNTLKLWD 242
Score = 53.9 bits (128), Expect = 3e-07
Identities = 64/315 (20%), Positives = 126/315 (40%), Gaps = 58/315 (18%)
Query: 50 LPSSVRSTLLELFGQIEREFEN------LYIENLELRREIDTLNERLAAEGQAIDGAELS 103
L SS L++++G + +FE L I ++ + + L A++ + + ++S
Sbjct: 60 LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVS--ASDDKTLKIWDVS 117
Query: 104 KGQ-LKTKASHST----SQLSQKLKTTYKASTSKIVSSFKTTTSRAACQLVKEYIGHRDG 158
G+ LKT HS + + S + V + T + +K H D
Sbjct: 118 SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC----LKTLPAHSDP 173
Query: 159 IWDVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGS-VNSIKFHPSEQLALTA 217
+ V + +++ ++S D +W +G+CL V+ +KF P+ + L A
Sbjct: 174 VSAVHFNRDGSLIV-SSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAA 232
Query: 218 SGDQTAHIWRYAVQLPTPQPVADTSISGEDEVECSDKDEPDLDGDVSSDCPTIRVPLTSL 277
+ D T +W Y+ + +C T
Sbjct: 233 TLDNTLKLWDYS------------------KGKCLK-------------------TYTGH 255
Query: 278 KSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRL 337
K+ + + A+ + GGK V+ S D +++++T E+V L GH + HPT+ +
Sbjct: 256 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENI 315
Query: 338 VVTSS--RDTTFRLW 350
+ +++ D T +LW
Sbjct: 316 IASAALENDKTIKLW 330
Score = 50.8 bits (120), Expect = 3e-06
Identities = 30/122 (24%), Positives = 59/122 (48%), Gaps = 3/122 (2%)
Query: 276 SLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQ 335
+L H V + + G+ ++S D+ ++ + +++GH ++
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 336 RLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDN-VVSGSDDRTVKVWD 394
L+V++S D T ++WD S + +GH++ V F N +VSGS D +V++WD
Sbjct: 100 NLLVSASDDKTLKIWDV--SSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
Query: 395 LK 396
+K
Sbjct: 158 VK 159
Score = 41.2 bits (95), Expect = 0.002
Identities = 35/140 (25%), Positives = 64/140 (45%), Gaps = 10/140 (7%)
Query: 315 LVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAV 374
L +L GH + ++ P + +SS D ++W D GH ++
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT--ISGHKLGISDVA 94
Query: 375 FTVGDNV-VSGSDDRTVKVWDLKNMRSPIATIRTDSAINRINVC---VGQKIIALPHDNR 430
++ N+ VS SDD+T+K+WD+ + + + T++ S N + C +I +
Sbjct: 95 WSSDSNLLVSASDDKTLKIWDVSSGKC-LKTLKGHS--NYVFCCNFNPQSNLIVSGSFDE 151
Query: 431 QVRLFDM-SGVRLARLPRSS 449
VR++D+ +G L LP S
Sbjct: 152 SVRIWDVKTGKCLKTLPAHS 171
Score = 40.0 bits (92), Expect = 0.005
Identities = 26/92 (28%), Positives = 48/92 (52%), Gaps = 10/92 (10%)
Query: 142 SRAACQLVKEYIGHRDGIWDV----SVAKTQPVVLGTASADHTALLWSIETGKCLVKYAG 197
S+ C +K Y GH++ + + SV + +V G S D+ +W+++T + + K G
Sbjct: 244 SKGKC--LKTYTGHKNEKYCIFANFSVTGGKWIVSG--SEDNLVYIWNLQTKEIVQKLQG 299
Query: 198 HVGSVNSIKFHPSEQLALTAS--GDQTAHIWR 227
H V S HP+E + +A+ D+T +W+
Sbjct: 300 HTDVVISTACHPTENIIASAALENDKTIKLWK 331
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 77.8 bits (190), Expect = 2e-14
Identities = 62/230 (26%), Positives = 102/230 (44%), Gaps = 15/230 (6%)
Query: 178 DHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLPTPQP 237
D ++W ++ ++ GH +V + F PS L + S D+T IW V+ +
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 238 VADTSISGEDEVECSDKDEPDLDGDVSSDCPTIRVPLT-------SLKSHQGVVIASDWL 290
A T+ CSD +SD T++V T SL H V + +
Sbjct: 62 RAHTATVRSVHF-CSDGQS----FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFS 116
Query: 291 VGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLW 350
G+ V+AS D+T L+D + E VHS H +T+ HP+ + + D T ++W
Sbjct: 117 PDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW 176
Query: 351 DFRDPSIHSVNVFQGHTDTVTSAVF-TVGDNVVSGSDDRTVKVWDLKNMR 399
D R + + +Q H+ V F G+ +++ S D T+K+ DL R
Sbjct: 177 DVRTHRL--LQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGR 224
Score = 70.1 bits (170), Expect = 4e-12
Identities = 55/221 (24%), Positives = 84/221 (38%), Gaps = 43/221 (19%)
Query: 174 TASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLP 233
TAS D T +W+ K L + H+ V KF P +L ++AS D+T +W
Sbjct: 82 TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW------- 134
Query: 234 TPQPVADTSISGEDEVECSDKDEPDLDGDVSSDCPTIRVPLTSLKSHQGVVIASDWLVGG 293
DK S +C + S H G V D+ G
Sbjct: 135 -------------------DKS--------SREC------VHSYCEHGGFVTYVDFHPSG 161
Query: 294 KQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFR 353
A D T ++DV T L+ H + HP+ ++T+S D+T ++ D
Sbjct: 162 TCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLM 221
Query: 354 DPSIHSVNVFQGHTDTVTSAVFT-VGDNVVSGSDDRTVKVW 393
+ + + GH T+ F+ G+ SG D V VW
Sbjct: 222 EGRL--LYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260
Score = 45.1 bits (105), Expect = 2e-04
Identities = 20/54 (37%), Positives = 28/54 (51%)
Query: 172 LGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHI 225
+ A D+T +W + T + L Y H +VN + FHPS +TAS D T I
Sbjct: 164 IAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKI 217
Score = 31.2 bits (69), Expect = 2.3
Identities = 18/86 (20%), Positives = 35/86 (40%), Gaps = 9/86 (10%)
Query: 174 TASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWR------ 227
TAS+D T + + G+ L GH G ++ F + + + D+ +W+
Sbjct: 208 TASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIV 267
Query: 228 ---YAVQLPTPQPVADTSISGEDEVE 250
++P P +S+ EV+
Sbjct: 268 DHGEVTKVPRPPATLASSMGNLPEVD 293
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 77.8 bits (190), Expect = 2e-14
Identities = 56/204 (27%), Positives = 81/204 (39%), Gaps = 46/204 (22%)
Query: 196 AGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLPTPQPVADTSISGEDEVECSDKD 255
+GH G V KFHP+ +A D+ +W
Sbjct: 63 SGHEGEVYCCKFHPNGSTLASAGFDRLILLW----------------------------- 93
Query: 256 EPDLDGDVSSDCPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSEL 315
+V DC +LK H G V+ + G +AS D+T ++D ET E
Sbjct: 94 ------NVYGDCDNY----ATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGER 143
Query: 316 VHSLTGHDQELTHCCTHPTQR---LVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTS 372
V L GH + C +P +R LV T S D T +LWD R + ++ FQ +
Sbjct: 144 VKRLKGHTSFVNSC--YPARRGPQLVCTGSDDGTVKLWDIRKKA--AIQTFQNTYQVLAV 199
Query: 373 AVFTVGDNVVSGSDDRTVKVWDLK 396
D ++SG D +KVWDL+
Sbjct: 200 TFNDTSDQIISGGIDNDIKVWDLR 223
Score = 63.2 bits (152), Expect = 5e-10
Identities = 57/245 (23%), Positives = 99/245 (40%), Gaps = 24/245 (9%)
Query: 172 LGTASADHTALLWSIETGKC--LVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYA 229
L +A D LLW++ G C GH G+V + ++ + +AS D+T +W
Sbjct: 81 LASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSE 139
Query: 230 VQLPTPQPVADTSISGE-------DEVECSDKDEPDLDGDVSS-DCPTIRVPLTSLKSHQ 281
+ TS ++ C+ D DG V D T ++Q
Sbjct: 140 TGERVKRLKGHTSFVNSCYPARRGPQLVCTGSD----DGTVKLWDIRKKAAIQTFQNTYQ 195
Query: 282 GVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTS 341
V+A + Q ++ D ++D+ ++L +++ GH +T ++++
Sbjct: 196 --VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSN 253
Query: 342 SRDTTFRLWDFRD--PSIHSVNVFQGHTDTVTSAVFTV-----GDNVVSGSDDRTVKVWD 394
+ D T R+WD R P V +FQG+ + G + +GS DR V VWD
Sbjct: 254 AMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWD 313
Query: 395 LKNMR 399
+ R
Sbjct: 314 TTSRR 318
Score = 50.8 bits (120), Expect = 3e-06
Identities = 47/229 (20%), Positives = 91/229 (39%), Gaps = 15/229 (6%)
Query: 126 YKASTSKIVSSFKTTTSRAACQLVKEYIGHRDGIWDVSVAKTQPVVLGTASADHTALLWS 185
+ AST K V+ + + T + VK GH + A+ P ++ T S D T LW
Sbjct: 125 FSASTDKTVAVWDSETG----ERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
Query: 186 IETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLPT------PQPVA 239
I K ++ + V ++ F+ + ++ D +W T V
Sbjct: 181 IRK-KAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVT 239
Query: 240 DTSISGEDEVECSDK-DEPDLDGDVSSDCPT---IRVPLTSLKSHQGVVIASDWLVGGKQ 295
S+S E S+ D DV P +++ ++ + + ++ W G +
Sbjct: 240 GLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSK 299
Query: 296 AVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRD 344
S DR ++D + +++ L GH + HP + +++++S D
Sbjct: 300 IAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSD 348
Score = 46.6 bits (109), Expect = 5e-05
Identities = 18/54 (33%), Positives = 30/54 (55%)
Query: 172 LGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHI 225
+ SAD +W + + L K GH GS+N + FHP E + ++AS D+ ++
Sbjct: 300 IAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYM 353
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 76.3 bits (186), Expect = 6e-14
Identities = 67/254 (26%), Positives = 105/254 (41%), Gaps = 14/254 (5%)
Query: 150 KEYIGHRDGIWDVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHP 209
K GH I DV+ + ++ +AS D T LW + +GKCL GH V F+P
Sbjct: 77 KTLYGHNLEISDVAWSSDSSRLV-SASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNP 135
Query: 210 SEQLALTASGDQTAHIWRYAVQLPTPQPVADTSISGEDEVECSDK--DEPDLDGDVSS-D 266
L ++ S D+T IW A + CS DG D
Sbjct: 136 PSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195
Query: 267 CPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQEL 326
+ + T + V + GK +TA+ D T L+D + + TGH E
Sbjct: 196 AASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNE- 254
Query: 327 THCC----THPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDNVV 382
+C + + +V+ S D +W+ + I V QGHTD V SA +N++
Sbjct: 255 KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI--VQKLQGHTDVVISAACHPTENLI 312
Query: 383 SGS---DDRTVKVW 393
+ + +D+T+K+W
Sbjct: 313 ASAALENDKTIKLW 326
Score = 63.2 bits (152), Expect = 5e-10
Identities = 48/206 (23%), Positives = 85/206 (41%), Gaps = 45/206 (21%)
Query: 190 KCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLPTPQPVADTSISGEDEV 249
KC + GH +V+S+KF P+ + ++S D+ IW + G+ E
Sbjct: 34 KCTL--VGHTEAVSSVKFSPNGEWLASSSADRLIIIWG--------------AYDGKYE- 76
Query: 250 ECSDKDEPDLDGDVSSDCPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYD 309
+L H + W + V+AS D+T L+D
Sbjct: 77 -------------------------KTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWD 111
Query: 310 VETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDT 369
V + + + +L GH + C +P L+++ S D T ++W+ + + H+D
Sbjct: 112 VRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGK--CLKTLSAHSDP 169
Query: 370 VTSAVFTV-GDNVVSGSDDRTVKVWD 394
V++ F G +VSGS D ++WD
Sbjct: 170 VSAVHFNCSGSLIVSGSYDGLCRIWD 195
Score = 60.8 bits (146), Expect = 3e-09
Identities = 75/357 (21%), Positives = 142/357 (39%), Gaps = 56/357 (15%)
Query: 6 ASCSTARQTKQKRKSHSLSIRRTNSSEQERTGLPRDMLEGQDSKLPSSVRSTLLELFGQI 65
A S+A Q+K+ ++ + +++ T E + G+ L SS L+ ++G
Sbjct: 14 ALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGE--WLASSSADRLIIIWGAY 71
Query: 66 EREFEN-LYIENLELRR---EIDTLNERLAAEGQAIDGAELSKGQ-LKTKASHST----S 116
+ ++E LY NLE+ D+ A++ + + ++ G+ LKT HS
Sbjct: 72 DGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCC 131
Query: 117 QLSQKLKTTYKASTSKIVSSFKTTTSRAACQLVKEYIGHRDGIWDVSVAKTQPVVLGTAS 176
+ S + V ++ T + +K H D + V + +++ + S
Sbjct: 132 NFNPPSNLIISGSFDETVKIWEVKTGKC----LKTLSAHSDPVSAVHFNCSGSLIV-SGS 186
Query: 177 ADHTALLWSIETGKCLVKYAGHVGS-VNSIKFHPSEQLALTASGDQTAHIWRYAVQLPTP 235
D +W +G+CL V+ +KF P+ + LTA+ D T +W Y+
Sbjct: 187 YDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYS------ 240
Query: 236 QPVADTSISGEDEVECSDKDEPDLDGDVSSDCPTIRVPLTSLKSHQGVVIASDWLVGGKQ 295
C T K+ + + A+ + GGK
Sbjct: 241 ------------RGRCLK-------------------TYTGHKNEKYCIFANFSVTGGKW 269
Query: 296 AVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSS--RDTTFRLW 350
V+ S D +++++T E+V L GH + HPT+ L+ +++ D T +LW
Sbjct: 270 IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
Score = 54.7 bits (130), Expect = 2e-07
Identities = 38/155 (24%), Positives = 72/155 (46%), Gaps = 4/155 (2%)
Query: 276 SLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQ 335
+L H V + + G+ ++S DR ++ + +L GH+ E++
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95
Query: 336 RLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDN-VVSGSDDRTVKVWD 394
+V++S D T +LWD R S + +GH++ V F N ++SGS D TVK+W+
Sbjct: 96 SRLVSASDDKTLKLWDVR--SGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWE 153
Query: 395 LKNMRSPIATIRTDSAINRINV-CVGQKIIALPHD 428
+K + ++ ++ C G I++ +D
Sbjct: 154 VKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYD 188
Score = 37.7 bits (86), Expect = 0.024
Identities = 23/103 (22%), Positives = 50/103 (48%), Gaps = 3/103 (2%)
Query: 296 AVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDP 355
A+++S +++ + + L +L GH + ++ P + +SS D +W D
Sbjct: 14 ALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDG 73
Query: 356 SIHSVNVFQGHTDTVTSAVFTVGDN-VVSGSDDRTVKVWDLKN 397
GH ++ ++ + +VS SDD+T+K+WD+++
Sbjct: 74 KYEKT--LYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRS 114
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 75.5 bits (184), Expect = 1e-13
Identities = 54/252 (21%), Positives = 98/252 (38%), Gaps = 43/252 (17%)
Query: 149 VKEYIGHRDGIWDVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFH 208
++E + H + + + K +L T D LWSI C++ GH V S++ +
Sbjct: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLN 72
Query: 209 PSEQLALTASGDQTAHIWRYAVQLPTPQPVADTSISGEDEVECSDKDEPDLDGDVSSDCP 268
E+L + S + +W D
Sbjct: 73 TPEELIVAGSQSGSIRVW---------------------------------------DLE 93
Query: 269 TIRVPLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTH 328
++ L +L H+ + + D+ G+ + S D L+D+ V GH Q +
Sbjct: 94 AAKI-LRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRC 152
Query: 329 CCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDNVV-SGSDD 387
P + + +++ D T +LWD + ++ F GHT V F + ++ SGS D
Sbjct: 153 LRFSPDGKWLASAADDHTVKLWDLTAGKM--MSEFPGHTGPVNVVEFHPNEYLLASGSSD 210
Query: 388 RTVKVWDLKNMR 399
RT++ WDL+ +
Sbjct: 211 RTIRFWDLEKFQ 222
Score = 61.2 bits (147), Expect = 2e-09
Identities = 37/142 (26%), Positives = 67/142 (47%), Gaps = 3/142 (2%)
Query: 297 VTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPS 356
V S + ++D+E ++++ +L GH + HP V + S+DT +LWD R
Sbjct: 79 VAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKG 138
Query: 357 IHSVNVFQGHTDTVTSAVFTV-GDNVVSGSDDRTVKVWDLKNMRSPIATIRTDSAINRIN 415
V ++GH+ V F+ G + S +DD TVK+WDL + +N +
Sbjct: 139 --CVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVE 196
Query: 416 VCVGQKIIALPHDNRQVRLFDM 437
+ ++A +R +R +D+
Sbjct: 197 FHPNEYLLASGSSDRTIRFWDL 218
Score = 60.1 bits (144), Expect = 5e-09
Identities = 37/151 (24%), Positives = 65/151 (43%), Gaps = 3/151 (1%)
Query: 293 GKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDF 352
G+ T D NL+ + + SLTGH + + + L+V S+ + R+WD
Sbjct: 33 GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDL 92
Query: 353 RDPSIHSVNVFQGHTDTVTSAVF-TVGDNVVSGSDDRTVKVWDLKNMRSPIATIRTDSAI 411
I + GH + S F G+ V SGS D +K+WD++ A+
Sbjct: 93 EAAKI--LRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAV 150
Query: 412 NRINVCVGQKIIALPHDNRQVRLFDMSGVRL 442
+ K +A D+ V+L+D++ ++
Sbjct: 151 RCLRFSPDGKWLASAADDHTVKLWDLTAGKM 181
Score = 42.0 bits (97), Expect = 0.001
Identities = 21/82 (25%), Positives = 38/82 (46%), Gaps = 1/82 (1%)
Query: 145 ACQLVKEYIGHRDGIWDVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNS 204
A ++++ +GH+ I + V + S D LW I C+ +Y GH +V
Sbjct: 94 AAKILRTLMGHKANICSLDFHPYGEFV-ASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRC 152
Query: 205 IKFHPSEQLALTASGDQTAHIW 226
++F P + +A+ D T +W
Sbjct: 153 LRFSPDGKWLASAADDHTVKLW 174
Score = 32.3 bits (72), Expect = 1.0
Identities = 18/95 (18%), Positives = 41/95 (43%), Gaps = 6/95 (6%)
Query: 366 HTDTVTSAVF--TVGDNVVSGSDDRTVKVWDLKNMRSPIATIRTDSAINRINVCVGQKII 423
H V+S V G + +G DD V +W + ++ S + + + +++I
Sbjct: 19 HASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELI 78
Query: 424 ALPHDNRQVRLFDMSGVRLARLPRSSRQGHRRMVC 458
+ +R++D+ ++ R + GH+ +C
Sbjct: 79 VAGSQSGSIRVWDLEAAKILR----TLMGHKANIC 109
Score = 30.4 bits (67), Expect = 3.9
Identities = 19/67 (28%), Positives = 33/67 (49%), Gaps = 5/67 (7%)
Query: 145 ACQLVKEYIGHRDGIWDVSVAKTQP--VVLGTASADHTALLWSIETGKCLVKYAGHVGSV 202
A +++ E+ GH V+V + P +L + S+D T W +E + + G G V
Sbjct: 178 AGKMMSEFPGHTG---PVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPV 234
Query: 203 NSIKFHP 209
S+ F+P
Sbjct: 235 RSVLFNP 241
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 75.1 bits (183), Expect = 1e-13
Identities = 79/347 (22%), Positives = 134/347 (38%), Gaps = 56/347 (16%)
Query: 148 LVKEYIGHRDGIWDVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKF 207
L + + GH+ I + ++ L TAS D +LW+ + +Y GH V S++F
Sbjct: 10 LERYFKGHKAAITSLDLSPNGKQ-LATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQF 68
Query: 208 HPSEQLALTASGDQTAHIWRYAVQLPTPQPVADTSISGEDEVECSDKDEPDLDGDVSSDC 267
P L +AS D+T +W
Sbjct: 69 SPHGNLLASASRDRTVRLW----------------------------------------I 88
Query: 268 PTIRVPLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELT 327
P R + K+H V + D+ G+ TAS D++ ++ + ++SL H +
Sbjct: 89 PDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVR 148
Query: 328 HCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFT----VGDNVVS 383
P RL+V+ S D T ++WD + VN F +D+V A F G + S
Sbjct: 149 CAKFSPDGRLIVSCSEDKTIKIWDTTNK--QCVNNF---SDSVGFANFVDFNPSGTCIAS 203
Query: 384 GSDDRTVKVWDLKNMRSPIATIRTDSAINRINVCVGQKIIALPHDNRQVRLFDMSGVRLA 443
D+TVKVWD++ + +N I+ + + +++ D+ RL
Sbjct: 204 AGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLI 263
Query: 444 RLPRSSRQGHRRMVCCSAWSEDHPVCNLFTCGFDRQAIGWNINIPAL 490
+ QGH V ++S+ + + G D Q + W N L
Sbjct: 264 ----YTLQGHTGPVFTVSFSKGGEL--FASGGADTQVLLWRTNFDEL 304
Score = 34.7 bits (78), Expect = 0.20
Identities = 20/81 (24%), Positives = 38/81 (46%), Gaps = 1/81 (1%)
Query: 147 QLVKEYIGHRDGIWDVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIK 206
+L++ Y H G+ +S + ++ TAS+D T + + G+ + GH G V ++
Sbjct: 219 KLLQHYQVHSGGVNCISFHPSGNYLI-TASSDGTLKILDLLEGRLIYTLQGHTGPVFTVS 277
Query: 207 FHPSEQLALTASGDQTAHIWR 227
F +L + D +WR
Sbjct: 278 FSKGGELFASGGADTQVLLWR 298
>gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)
[Homo sapiens]
Length = 906
Score = 74.7 bits (182), Expect = 2e-13
Identities = 52/189 (27%), Positives = 85/189 (44%), Gaps = 9/189 (4%)
Query: 284 VIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSR 343
V A+ ++ VT + D +++ T E VH H + HPTQ ++TSS
Sbjct: 60 VRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSD 119
Query: 344 DTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDN--VVSGSDDRTVKVWDLKNMRSP 401
D +LWD+ D VF+GHT V V DN S S DRT+KVW L +
Sbjct: 120 DMLIKLWDW-DKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPN 178
Query: 402 IATIRTDSAINRINVCVG--QKIIALPHDNRQVRLFDMSGVRLARLPRSSRQGHRRMVCC 459
+ +N I+ G + + D+R V+++D + + +GH + V C
Sbjct: 179 FTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQ----TLEGHAQNVSC 234
Query: 460 SAWSEDHPV 468
+++ + P+
Sbjct: 235 ASFHPELPI 243
Score = 55.1 bits (131), Expect = 1e-07
Identities = 44/186 (23%), Positives = 81/186 (43%), Gaps = 12/186 (6%)
Query: 174 TASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLP 233
T + D +++ T + + + H + I HP++ LT+S D +W + +
Sbjct: 74 TGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWS 133
Query: 234 TPQPVADTSISGEDEVECSDKDEPDLDGDVSSDCPTIRV-------PLTSLKSHQGVVIA 286
Q V + ++ + KD S D TI+V P +L+ H+ V
Sbjct: 134 CSQ-VFEGHTHYVMQIVINPKDNNQF-ASASLD-RTIKVWQLGSSSPNFTLEGHEKGVNC 190
Query: 287 SDWLVGGKQA--VTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRD 344
D+ GG + ++ + DR ++D + V +L GH Q ++ HP +++T S D
Sbjct: 191 IDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSED 250
Query: 345 TTFRLW 350
T R+W
Sbjct: 251 GTVRIW 256
Score = 44.7 bits (104), Expect = 2e-04
Identities = 30/122 (24%), Positives = 64/122 (52%), Gaps = 14/122 (11%)
Query: 295 QAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPT---QRLVVTSSRDTTFRLWD 351
Q +AS DRT ++ + +S +L GH++ + +C + + + +++ + D ++WD
Sbjct: 157 QFASASLDRTIKVWQLGSSSPNFTLEGHEKGV-NCIDYYSGGDKPYLISGADDRLVKIWD 215
Query: 352 FRDPSIHSVNVFQGHTDTVTSAVFTVG-DNVVSGSDDRTVKVWDLKNMRSPIATIRTDSA 410
+++ + V +GH V+ A F +++GS+D TV++W +T R +S
Sbjct: 216 YQNKTC--VQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWH-------SSTYRLEST 266
Query: 411 IN 412
+N
Sbjct: 267 LN 268
Score = 29.3 bits (64), Expect = 8.6
Identities = 21/86 (24%), Positives = 32/86 (37%), Gaps = 4/86 (4%)
Query: 145 ACQLVKEYIGHRDGIWDVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNS 204
+C V E GH + + + +AS D T +W + + GH VN
Sbjct: 133 SCSQVFE--GHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNC 190
Query: 205 IKFHPSEQLALTASG--DQTAHIWRY 228
I ++ SG D+ IW Y
Sbjct: 191 IDYYSGGDKPYLISGADDRLVKIWDY 216
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 72.8 bits (177), Expect = 7e-13
Identities = 68/274 (24%), Positives = 111/274 (40%), Gaps = 46/274 (16%)
Query: 123 KTTYKASTSKIVSSFKTTTSRAACQLVKEYIGHRDGIWDVSVAKTQPVVLGTASADHTAL 182
+T S +V +K R Q E GH+ G+ V ++ T P+ ++S D
Sbjct: 33 ETVVTGSLDDLVKVWKWRDERLDLQWSLE--GHQLGVVSVDISHTLPIA-ASSSLDAHIR 89
Query: 183 LWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLPTPQPVADTS 242
LW +E GK + SI P + L S D L T V +
Sbjct: 90 LWDLENGK----------QIKSIDAGPVDAWTLAFSPDSQ--------YLATGTHVGKVN 131
Query: 243 ISGEDEVECSDKDEPDLDGDVSSDCPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTASWD 302
I G + S K E LD + +++ + GK + + D
Sbjct: 132 IFGVE----SGKKEYSLD------------------TRGKFILSIAYSPDGKYLASGAID 169
Query: 303 RTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVNV 362
N++D+ T +L+H+L GH + P +L+VT+S D +++D + ++
Sbjct: 170 GIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANL--AGT 227
Query: 363 FQGHTDTVTSAVFTVGD-NVVSGSDDRTVKVWDL 395
GH V + F D + VS S D++VKVWD+
Sbjct: 228 LSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDV 261
Score = 31.2 bits (69), Expect = 2.3
Identities = 18/61 (29%), Positives = 30/61 (49%), Gaps = 1/61 (1%)
Query: 338 VVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDNVVSGSD-DRTVKVWDLK 396
VVT S D ++W +RD + +GH V S + + + S D +++WDL+
Sbjct: 35 VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94
Query: 397 N 397
N
Sbjct: 95 N 95
>gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]
Length = 607
Score = 72.4 bits (176), Expect = 9e-13
Identities = 61/210 (29%), Positives = 102/210 (48%), Gaps = 12/210 (5%)
Query: 241 TSISGEDEVECSDKDEPDLDGDVSSDCPTIRVPLTSL---KSHQGVVIASDWLVGGKQAV 297
T+I G V + ++D S +RVP T+L +H G V A + G +
Sbjct: 280 TNIFGRRSVSSFPVPQDNVDTHPGSG-KEVRVPATALCVFDAHDGEVNAVQFSPGSRLLA 338
Query: 298 TASWDRTANLYDV--ETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDP 355
T DR L++V E E SL+G + +T ++ +S D R+W D
Sbjct: 339 TGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDY 398
Query: 356 SIHSVNVFQGHTDTVTSAVFTVGD-NVVSGSDDRTVKVWDLKNMRSPIATIRTDSAINRI 414
+ + GH+ V SA F + + +VSGS DRT+K+WDL++ + I T+ S+ N I
Sbjct: 399 RLR--HTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRS-KVCIKTVFAGSSCNDI 455
Query: 415 NVCVGQKIIALPHDNRQVRLFDMSGVRLAR 444
VC Q +++ H ++++R +D+ + R
Sbjct: 456 -VCTEQCVMS-GHFDKKIRFWDIRSESIVR 483
Score = 52.8 bits (125), Expect = 7e-07
Identities = 45/206 (21%), Positives = 80/206 (38%), Gaps = 42/206 (20%)
Query: 192 LVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLPTPQPVADTSISGEDEVEC 251
L + H G VN+++F P +L T D+ +W + GE +C
Sbjct: 315 LCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLW---------------EVFGE---KC 356
Query: 252 SDKDEPDLDGDVSSDCPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVE 311
K SL + + ++ G + AS D + ++ V+
Sbjct: 357 EFKG--------------------SLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVD 396
Query: 312 TSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVT 371
L H+LTGH ++ +V+ S D T +LWD R + VF G +
Sbjct: 397 DYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRS-KVCIKTVFAGSS---C 452
Query: 372 SAVFTVGDNVVSGSDDRTVKVWDLKN 397
+ + V+SG D+ ++ WD+++
Sbjct: 453 NDIVCTEQCVMSGHFDKKIRFWDIRS 478
Score = 33.5 bits (75), Expect = 0.46
Identities = 46/260 (17%), Positives = 97/260 (37%), Gaps = 23/260 (8%)
Query: 146 CQLVKEYIGHRDGIWDVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSI 205
C+ G GI + +L AS D + +W+++ + GH G V S
Sbjct: 356 CEFKGSLSGSNAGITSIEFDSAGSYLLA-ASNDFASRIWTVDDYRLRHTLTGHSGKVLSA 414
Query: 206 KFHPSEQLALTASGDQTAHIWRYAVQLPTPQPVADTSISGEDEVECSDK-------DEPD 258
KF ++ S D+T +W ++ A +S +++ C+++ D+
Sbjct: 415 KFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSC---NDIVCTEQCVMSGHFDKKI 471
Query: 259 LDGDVSSDCPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHS 318
D+ S+ + L G + A D + ++ S D + D+ T+ + +
Sbjct: 472 RFWDIRSESIVREMELL------GKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQT 525
Query: 319 LTGH----DQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAV 374
+ + T P V S + + +W + V + + H+ ++ +
Sbjct: 526 FSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKV-LSKQHSSSINAVA 584
Query: 375 FT-VGDNVVSGSDDRTVKVW 393
++ G +VVS +W
Sbjct: 585 WSPSGSHVVSVDKGCKAVLW 604
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.129 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,780,572
Number of Sequences: 37866
Number of extensions: 751955
Number of successful extensions: 5045
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 182
Number of HSP's successfully gapped in prelim test: 137
Number of HSP's that attempted gapping in prelim test: 2949
Number of HSP's gapped (non-prelim): 1423
length of query: 494
length of database: 18,247,518
effective HSP length: 106
effective length of query: 388
effective length of database: 14,233,722
effective search space: 5522684136
effective search space used: 5522684136
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.