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Search of human proteins with 40317628
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40317628 thrombospondin 2 precursor [Homo sapiens]
(1172 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40317628 thrombospondin 2 precursor [Homo sapiens] 2547 0.0
gi|40317626 thrombospondin 1 precursor [Homo sapiens] 1631 0.0
gi|40217843 cartilage oligomeric matrix protein precursor [Homo ... 759 0.0
gi|6005902 thrombospondin 3 precursor [Homo sapiens] 738 0.0
gi|31543806 thrombospondin 4 precursor [Homo sapiens] 718 0.0
gi|118572606 hemicentin 1 [Homo sapiens] 178 2e-44
gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [... 160 9e-39
gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens] 157 6e-38
gi|4505737 complement factor properdin precursor [Homo sapiens] 149 2e-35
gi|223671861 complement factor properdin precursor [Homo sapiens] 149 2e-35
gi|115387099 brain-specific angiogenesis inhibitor 2 [Homo sapiens] 145 3e-34
gi|147904700 semaphorin 5A [Homo sapiens] 133 1e-30
gi|134031945 SCO-spondin [Homo sapiens] 129 1e-29
gi|91982767 semaphorin 5B isoform 1 [Homo sapiens] 124 5e-28
gi|32261318 unc-5 homolog B [Homo sapiens] 110 6e-24
gi|209977117 unc-5 homolog D [Homo sapiens] 110 6e-24
gi|16933525 unc5C [Homo sapiens] 109 1e-23
gi|110347423 spondin 1, extracellular matrix protein [Homo sapiens] 109 1e-23
gi|126091152 cubilin [Homo sapiens] 86 3e-16
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 84 1e-15
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 82 2e-15
gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo s... 82 3e-15
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 81 7e-15
gi|24430141 fibrillin 1 precursor [Homo sapiens] 80 1e-14
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 79 2e-14
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 77 7e-14
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 77 1e-13
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 76 2e-13
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 76 2e-13
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 76 2e-13
>gi|40317628 thrombospondin 2 precursor [Homo sapiens]
Length = 1172
Score = 2547 bits (6602), Expect = 0.0
Identities = 1172/1172 (100%), Positives = 1172/1172 (100%)
Query: 1 MVWRLVLLALWVWPSTQAGHQDKDTTFDLFSISNINRKTIGAKQFRGPDPGVPAYRFVRF 60
MVWRLVLLALWVWPSTQAGHQDKDTTFDLFSISNINRKTIGAKQFRGPDPGVPAYRFVRF
Sbjct: 1 MVWRLVLLALWVWPSTQAGHQDKDTTFDLFSISNINRKTIGAKQFRGPDPGVPAYRFVRF 60
Query: 61 DYIPPVNADDLSKITKIMRQKEGFFLTAQLKQDGKSRGTLLALEGPGLSQRQFEIVSNGP 120
DYIPPVNADDLSKITKIMRQKEGFFLTAQLKQDGKSRGTLLALEGPGLSQRQFEIVSNGP
Sbjct: 61 DYIPPVNADDLSKITKIMRQKEGFFLTAQLKQDGKSRGTLLALEGPGLSQRQFEIVSNGP 120
Query: 121 ADTLDLTYWIDGTRHVVSLEDVGLADSQWKNVTVQVAGETYSLHVGCDLIDSFALDEPFY 180
ADTLDLTYWIDGTRHVVSLEDVGLADSQWKNVTVQVAGETYSLHVGCDLIDSFALDEPFY
Sbjct: 121 ADTLDLTYWIDGTRHVVSLEDVGLADSQWKNVTVQVAGETYSLHVGCDLIDSFALDEPFY 180
Query: 181 EHLQAEKSRMYVAKGSARESHFRGLLQNVHLVFENSVEDILSKKGCQQGQGAEINAISEN 240
EHLQAEKSRMYVAKGSARESHFRGLLQNVHLVFENSVEDILSKKGCQQGQGAEINAISEN
Sbjct: 181 EHLQAEKSRMYVAKGSARESHFRGLLQNVHLVFENSVEDILSKKGCQQGQGAEINAISEN 240
Query: 241 TETLRLGPHVTTEYVGPSSERRPEVCERSCEELGNMVQELSGLHVLVNQLSENLKRVSND 300
TETLRLGPHVTTEYVGPSSERRPEVCERSCEELGNMVQELSGLHVLVNQLSENLKRVSND
Sbjct: 241 TETLRLGPHVTTEYVGPSSERRPEVCERSCEELGNMVQELSGLHVLVNQLSENLKRVSND 300
Query: 301 NQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTTCTCKKFKTICHQITCPPATC 360
NQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTTCTCKKFKTICHQITCPPATC
Sbjct: 301 NQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTTCTCKKFKTICHQITCPPATC 360
Query: 361 ASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSI 420
ASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSI
Sbjct: 361 ASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSI 420
Query: 421 QTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSG 480
QTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSG
Sbjct: 421 QTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSG 480
Query: 481 RETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQER 540
RETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQER
Sbjct: 481 RETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQER 540
Query: 541 QMCNKRSCPVDGCLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDI 600
QMCNKRSCPVDGCLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDI
Sbjct: 541 QMCNKRSCPVDGCLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDI 600
Query: 601 CFSTSKVPRCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCKDKTHNCH 660
CFSTSKVPRCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCKDKTHNCH
Sbjct: 601 CFSTSKVPRCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCKDKTHNCH 660
Query: 661 KHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNLNLVCATNATYHCIKDNC 720
KHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNLNLVCATNATYHCIKDNC
Sbjct: 661 KHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNLNLVCATNATYHCIKDNC 720
Query: 721 PHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKDEVGDRCDNCP 780
PHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKDEVGDRCDNCP
Sbjct: 721 PHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKDEVGDRCDNCP 780
Query: 781 YVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPL 840
YVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPL
Sbjct: 781 YVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPL 840
Query: 841 VHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQGDACDPDD 900
VHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQGDACDPDD
Sbjct: 841 VHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQGDACDPDD 900
Query: 901 DNDGVPDDRDNCRLVFNPDQEDLDGDGRGDICKDDFDNDNIPDIDDVCPENNAISETDFR 960
DNDGVPDDRDNCRLVFNPDQEDLDGDGRGDICKDDFDNDNIPDIDDVCPENNAISETDFR
Sbjct: 901 DNDGVPDDRDNCRLVFNPDQEDLDGDGRGDICKDDFDNDNIPDIDDVCPENNAISETDFR 960
Query: 961 NFQMVPLDPKGTTQIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDR 1020
NFQMVPLDPKGTTQIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDR
Sbjct: 961 NFQMVPLDPKGTTQIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDR 1020
Query: 1021 DDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRN 1080
DDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRN
Sbjct: 1021 DDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRN 1080
Query: 1081 ALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPI 1140
ALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPI
Sbjct: 1081 ALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPI 1140
Query: 1141 YDQTYAGGRLGLFVFSQEMVYFSDLKYECRDI 1172
YDQTYAGGRLGLFVFSQEMVYFSDLKYECRDI
Sbjct: 1141 YDQTYAGGRLGLFVFSQEMVYFSDLKYECRDI 1172
>gi|40317626 thrombospondin 1 precursor [Homo sapiens]
Length = 1170
Score = 1631 bits (4223), Expect = 0.0
Identities = 720/1151 (62%), Positives = 887/1151 (77%), Gaps = 12/1151 (1%)
Query: 24 DTTFDLFSISNINRKTIGAKQFRGPDPGVPAYRFVRFDYIPPVNADDLSKITKIMRQKEG 83
++ FD+F ++ RK G + +GPDP PA+R + IPPV D + +R ++G
Sbjct: 28 NSVFDIFELTGAARKGSGRRLVKGPDPSSPAFRIEDANLIPPVPDDKFQDLVDAVRAEKG 87
Query: 84 FFLTAQLKQDGKSRGTLLALEGPGLSQRQFEIVSNGPADTLDLTYWIDGTRHVVSLEDVG 143
F L A L+Q K+RGTLLALE S + F +VSNG A TLDL+ + G +HVVS+E+
Sbjct: 88 FLLLASLRQMKKTRGTLLALERKDHSGQVFSVVSNGKAGTLDLSLTVQGKQHVVSVEEAL 147
Query: 144 LADSQWKNVTVQVAGETYSLHVGCDLIDSFALDEPF---YEHLQAEKSRMYVAKGSARES 200
LA QWK++T+ V + L++ C+ +++ LD P + A +R+ +AKG ++
Sbjct: 148 LATGQWKSITLFVQEDRAQLYIDCEKMENAELDVPIQSVFTRDLASIARLRIAKGGVNDN 207
Query: 201 HFRGLLQNVHLVFENSVEDILSKKGCQQGQGAEINAISENTETLRLGPHVTTEYVGPSSE 260
F+G+LQNV VF + EDIL KGC + +N P + T Y+G ++
Sbjct: 208 -FQGVLQNVRFVFGTTPEDILRNKGCSSSTSVLLTL--DNNVVNGSSPAIRTNYIGHKTK 264
Query: 261 RRPEVCERSCEELGNMVQELSGLHVLVNQLSENLKRVSNDNQFLWELIGGPPKTRNMSAC 320
+C SC+EL +MV EL GL +V L +++++V+ +N+ L + PP C
Sbjct: 265 DLQAICGISCDELSSMVLELRGLRTIVTTLQDSIRKVTEENKELANELRRPP------LC 318
Query: 321 WQDGRFFAENETWVVDSCTTCTCKKFKTICHQITCPPATCASPSFVEGECCPSCLHSVDG 380
+ +G + NE W VDSCT C C+ TIC +++CP C++ + +GECCP C S
Sbjct: 319 YHNGVQYRNNEEWTVDSCTECHCQNSVTICKKVSCPIMPCSNATVPDGECCPRCWPSDSA 378
Query: 381 EEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGW 440
++GWSPW+EWT CS +CG+G QQRGRSCD +N C G S+QTR C + +CD R +QDGGW
Sbjct: 379 DDGWSPWSEWTSCSTSCGNGIQQRGRSCDSLNNRCEGSSVQTRTCHIQECDKRFKQDGGW 438
Query: 441 SHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRWSPW 500
SHWSPWSSCSVTCG G ITRIRLCNSP PQM GK C+G RETKAC+ CPI+G W PW
Sbjct: 439 SHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACPINGGWGPW 498
Query: 501 SPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVDGCLSNPCFP 560
SPW C+VTC GG+++R+R+CN+P PQ+GGK CVGDV E Q+CNK+ CP+DGCLSNPCF
Sbjct: 499 SPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQDCPIDGCLSNPCFA 558
Query: 561 GAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHCL 620
G +C+S+PDGSW CG+CP G+ GNG C D+DEC VPD CF+ + RC NT PG++CL
Sbjct: 559 GVKCTSYPDGSWKCGACPPGYSGNGIQCTDVDECKEVPDACFNHNGEHRCENTDPGYNCL 618
Query: 621 PCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCKDKTHNCHKHAECIYLGHFSDPMYKCEC 680
PCPPR+ G+QP G G+E A KQVC+P NPC D TH+C+K+A+C YLGH+SDPMY+CEC
Sbjct: 619 PCPPRFTGSQPFGQGVEHATANKQVCKPRNPCTDGTHDCNKNAKCNYLGHYSDPMYRCEC 678
Query: 681 QTGYAGDGLICGEDSDLDGWPNLNLVCATNATYHCIKDNCPHLPNSGQEDFDKDGIGDAC 740
+ GYAG+G+ICGED+DLDGWPN NLVC NATYHC KDNCP+LPNSGQED+DKDGIGDAC
Sbjct: 679 KPGYAGNGIICGEDTDLDGWPNENLVCVANATYHCKKDNCPNLPNSGQEDYDKDGIGDAC 738
Query: 741 DDDDDNDGVTDEKDNCQLLFNPRQADYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACS 800
DDDDDND + D++DNC +NP Q DYD+D+VGDRCDNCPY HNP Q DTDNNGEGDAC+
Sbjct: 739 DDDDDNDKIPDDRDNCPFHYNPAQYDYDRDDVGDRCDNCPYNHNPDQADTDNNGEGDACA 798
Query: 801 VDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTDVDNDLVGDQCDN 860
DIDGD + NERDNC YVYN DQRDTD DGVGD CDNCPL HNPDQ D D+D +GD CDN
Sbjct: 799 ADIDGDGILNERDNCQYVYNVDQRDTDMDGVGDQCDNCPLEHNPDQLDSDSDRIGDTCDN 858
Query: 861 NEDIDDDGHQNNQDNCPYISNANQADHDRDGQGDACDPDDDNDGVPDDRDNCRLVFNPDQ 920
N+DID+DGHQNN DNCPY+ NANQADHD+DG+GDACD DDDNDG+PDD+DNCRLV NPDQ
Sbjct: 859 NQDIDEDGHQNNLDNCPYVPNANQADHDKDGKGDACDHDDDNDGIPDDKDNCRLVPNPDQ 918
Query: 921 EDLDGDGRGDICKDDFDNDNIPDIDDVCPENNAISETDFRNFQMVPLDPKGTTQIDPNWV 980
+D DGDGRGD CKDDFD+D++PDIDD+CPEN ISETDFR FQM+PLDPKGT+Q DPNWV
Sbjct: 919 KDSDGDGRGDACKDDFDHDSVPDIDDICPENVDISETDFRRFQMIPLDPKGTSQNDPNWV 978
Query: 981 IRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVV 1040
+RHQGKELVQT N DPG+AVG+DEF +VDFSGTF++NT+RDDDYAGFVFGYQSSSRFYVV
Sbjct: 979 VRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGTFFINTERDDDYAGFVFGYQSSSRFYVV 1038
Query: 1041 MWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPR 1100
MWKQVTQ+YW+ PTRA GYSG+S+KVVNSTTG GEHLRNALWHTGNTPGQVRTLWHDPR
Sbjct: 1039 MWKQVTQSYWDTNPTRAQGYSGLSVKVVNSTTGPGEHLRNALWHTGNTPGQVRTLWHDPR 1098
Query: 1101 NIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMV 1160
+IGWKD+TAYRW L+HRPKTG+IRV+++EGK++MADSGPIYD+TYAGGRLGLFVFSQEMV
Sbjct: 1099 HIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKIMADSGPIYDKTYAGGRLGLFVFSQEMV 1158
Query: 1161 YFSDLKYECRD 1171
+FSDLKYECRD
Sbjct: 1159 FFSDLKYECRD 1169
>gi|40217843 cartilage oligomeric matrix protein precursor [Homo
sapiens]
Length = 757
Score = 759 bits (1959), Expect = 0.0
Identities = 362/669 (54%), Positives = 435/669 (65%), Gaps = 58/669 (8%)
Query: 549 PVDGCLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDICFSTSKVP 608
P+ C CFPG C G+ CG CP GF GNG+HC D++EC P CF
Sbjct: 87 PLLHCAPGFCFPGVACIQTESGA-RCGPCPAGFTGNGSHCTDVNECNAHP--CFPRV--- 140
Query: 609 RCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCKDKTHNC--------- 659
RC+NT PGF C CPP Y G GVGL AK KQVC N C+ HNC
Sbjct: 141 RCINTSPGFRCEACPPGYSGPTHQGVGLAFAKANKQVCTDINECETGQHNCVPNSVCINT 200
Query: 660 -------------------------------------HKHAECIYLGHFSDPMYKCECQT 682
H+HA+C+ D C C
Sbjct: 201 RGSFQCGPCQPGFVGDQASGCQRRAQRFCPDGSPSECHEHADCVLE---RDGSRSCVCAV 257
Query: 683 GYAGDGLICGEDSDLDGWPNLNLVCATNATYHCIKDNCPHLPNSGQEDFDKDGIGDACDD 742
G+AG+G++CG D+DLDG+P+ L C C KDNC +PNSGQED D+DGIGDACD
Sbjct: 258 GWAGNGILCGRDTDLDGFPDEKLRCPER---QCRKDNCVTVPNSGQEDVDRDGIGDACDP 314
Query: 743 DDDNDGVTDEKDNCQLLFNPRQADYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVD 802
D D DGV +EKDNC L+ NP Q + D+D+ GD CDNC N Q DTD +G GDAC D
Sbjct: 315 DADGDGVPNEKDNCPLVRNPDQRNTDEDKWGDACDNCRSQKNDDQKDTDQDGRGDACDDD 374
Query: 803 IDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTDVDNDLVGDQCDNNE 862
IDGD + N+ DNCP V N+DQ+D+DGDG+GD CDNCP NPDQ DVD+D VGD CD+++
Sbjct: 375 IDGDRIRNQADNCPRVPNSDQKDSDGDGIGDACDNCPQKSNPDQADVDHDFVGDACDSDQ 434
Query: 863 DIDDDGHQNNQDNCPYISNANQADHDRDGQGDACDPDDDNDGVPDDRDNCRLVFNPDQED 922
D D DGHQ+++DNCP + N+ Q D D DGQGDACD DDDNDGVPD RDNCRLV NP QED
Sbjct: 435 DQDGDGHQDSRDNCPTVPNSAQEDSDHDGQGDACDDDDDNDGVPDSRDNCRLVPNPGQED 494
Query: 923 LDGDGRGDICKDDFDNDNIPDIDDVCPENNAISETDFRNFQMVPLDPKGTTQIDPNWVIR 982
D DG GD+C+DDFD D + D DVCPEN ++ TDFR FQ V LDP+G QIDPNWV+
Sbjct: 495 ADRDGVGDVCQDDFDADKVVDKIDVCPENAEVTLTDFRAFQTVVLDPEGDAQIDPNWVVL 554
Query: 983 HQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMW 1042
+QG+E+VQT NSDPG+AVG+ F VDF GTF+VNT DDDYAGF+FGYQ SS FYVVMW
Sbjct: 555 NQGREIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFIFGYQDSSSFYVVMW 614
Query: 1043 KQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPRNI 1102
KQ+ QTYW+ P RA G+ LK V S+TG GE LRNALWHTG+T QVR LW DPRN+
Sbjct: 615 KQMEQTYWQANPFRAVAEPGIQLKAVKSSTGPGEQLRNALWHTGDTESQVRLLWKDPRNV 674
Query: 1103 GWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMVYF 1162
GWKD +YRW L HRP+ GYIRV +EG +++ADS + D T GGRLG+F FSQE + +
Sbjct: 675 GWKDKKSYRWFLQHRPQVGYIRVRFYEGPELVADSNVVLDTTMRGGRLGVFCFSQENIIW 734
Query: 1163 SDLKYECRD 1171
++L+Y C D
Sbjct: 735 ANLRYRCND 743
>gi|6005902 thrombospondin 3 precursor [Homo sapiens]
Length = 956
Score = 738 bits (1904), Expect = 0.0
Identities = 353/669 (52%), Positives = 430/669 (64%), Gaps = 58/669 (8%)
Query: 553 CLSNPCFPGAQCSS-FPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDICFSTSKVPRCV 611
C NPCF G C + + CG CP G GNGTHC D++ECA D CF S C+
Sbjct: 278 CSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHA-DPCFPGSS---CI 333
Query: 612 NTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCKDKTHN------------- 658
NT PGFHC CP Y+G Q GVG++ A+ KQVC + C D +
Sbjct: 334 NTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVG 393
Query: 659 --------------------------------CHKHAECIYLGHFSDPMYKCECQTGYAG 686
CH HA C++ + + C+C G+AG
Sbjct: 394 SFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGA---VSCQCNVGWAG 450
Query: 687 DGLICGEDSDLDGWPNLNLVCATNATYHCIKDNCPHLPNSGQEDFDKDGIGDACDDDDDN 746
+G +CG D+D+DG+P+ L C N HC +DNC PNSGQED D DG+GD CDDD D
Sbjct: 451 NGNVCGTDTDIDGYPDQALPCMDN-NKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADG 509
Query: 747 DGVTDEKDNCQLLFNPRQADYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGD 806
DG+ + +DNC+L N Q + D D GD CDNCP V N Q DTD NGEGDAC D+DGD
Sbjct: 510 DGIKNVEDNCRLFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVDGD 569
Query: 807 DVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTDVDNDLVGDQCDNNEDIDD 866
+ N DNCP V N Q D D DGVGD CD+CP + NP QTD D+DLVGD CD NED D
Sbjct: 570 GIPNGLDNCPKVPNPLQTDRDEDGVGDACDSCPEMSNPTQTDADSDLVGDVCDTNEDSDG 629
Query: 867 DGHQNNQDNCPYISNANQADHDRDGQGDACDPDDDNDGVPD----DRDNCRLVFNPDQED 922
DGHQ+ +DNCP + N++Q D D DG GD CD DDDNDG+PD DNCRLV NP+Q+D
Sbjct: 630 DGHQDTKDNCPQLPNSSQLDSDNDGLGDECDGDDDNDGIPDYVPPGPDNCRLVPNPNQKD 689
Query: 923 LDGDGRGDICKDDFDNDNIPDIDDVCPENNAISETDFRNFQMVPLDPKGTTQIDPNWVIR 982
DG+G GD+C+DDFDND + D DVCPE+ ++ TDFR +Q V LDP+G QIDPNWV+
Sbjct: 690 SDGNGVGDVCEDDFDNDAVVDPLDVCPESAEVTLTDFRAYQTVVLDPEGDAQIDPNWVVL 749
Query: 983 HQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMW 1042
+QG E+VQT NSDPG+AVG+ F VDF GTF+VNT DDDYAGF+F YQ S RFYVVMW
Sbjct: 750 NQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFLFSYQDSGRFYVVMW 809
Query: 1043 KQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPRNI 1102
KQ QTYW+ P RA G+ LK V S +G GEHLRNALWHTG+TP QVR LW DPRN+
Sbjct: 810 KQTEQTYWQATPFRAVAQPGLQLKAVTSVSGPGEHLRNALWHTGHTPDQVRLLWTDPRNV 869
Query: 1103 GWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMVYF 1162
GW+D T+YRW L HRP+ GYIRV ++EG Q++ADSG I D + GGRLG+F FSQE + +
Sbjct: 870 GWRDKTSYRWQLLHRPQVGYIRVKLYEGPQLVADSGVIIDTSMRGGRLGVFCFSQENIIW 929
Query: 1163 SDLKYECRD 1171
S+L+Y C D
Sbjct: 930 SNLQYRCND 938
Score = 32.7 bits (73), Expect = 2.1
Identities = 34/160 (21%), Positives = 62/160 (38%), Gaps = 6/160 (3%)
Query: 73 KITKIMRQKEGFFLTAQLKQDGKSRGTLLALEGPGLSQRQFEIVSNGPADTLDLTYWI-D 131
KI + +L + + K G L L + R E G + + + Y D
Sbjct: 45 KIRTALLTAGDIYLLSTFRLPPKQGGVLFGLYSRQDNTRWLEASVVGKINKVLVRYQRED 104
Query: 132 GTRHVVSLEDVGLADSQWKNVTVQVAGET-----YSLHVGCDLIDSFALDEPFYEHLQAE 186
G H V+L+ GLAD + V +++ G + L+V C L D A AE
Sbjct: 105 GKVHAVNLQQAGLADGRTHTVLLRLRGPSRPSPALHLYVDCKLGDQHAGLPALAPIPPAE 164
Query: 187 KSRMYVAKGSARESHFRGLLQNVHLVFENSVEDILSKKGC 226
+ + G +G ++++ ++ S+ + + C
Sbjct: 165 VDGLEIRTGQKAYLRMQGFVESMKIILGGSMARVGALSEC 204
>gi|31543806 thrombospondin 4 precursor [Homo sapiens]
Length = 961
Score = 718 bits (1853), Expect = 0.0
Identities = 351/669 (52%), Positives = 425/669 (63%), Gaps = 58/669 (8%)
Query: 549 PVDGCLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDICFSTSKVP 608
P C SNPCF G QC+ DG + CG CP G+ GNG C D+DEC P C+
Sbjct: 286 PPRRCDSNPCFRGVQCTDSRDG-FQCGPCPEGYTGNGITCIDVDECKYHP--CYPGV--- 339
Query: 609 RCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCKD-------------- 654
C+N PGF C CP + G GVG+ AK+ KQVC + C++
Sbjct: 340 HCINLSPGFRCDACPVGFTGPMVQGVGISFAKSNKQVCTDIDECRNGACVPNSICVNTLG 399
Query: 655 ----------------------------KTHNCHKHAECIYLGHFSDPMYKCECQTGYAG 686
+ + C +A+CI C C G+AG
Sbjct: 400 SYRCGPCKPGYTGDQIRGCKAERNCRNPELNPCSVNAQCI---EERQGDVTCVCGVGWAG 456
Query: 687 DGLICGEDSDLDGWPNLNLVCATNATYHCIKDNCPHLPNSGQEDFDKDGIGDACDDDDDN 746
DG ICG+D D+D +P+ L C+ +C KDNC ++PNSGQED D+DGIGDACD+D D
Sbjct: 457 DGYICGKDVDIDSYPDEELPCSAR---NCKKDNCKYVPNSGQEDADRDGIGDACDEDADG 513
Query: 747 DGVTDEKDNCQLLFNPRQADYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGD 806
DG+ +E+DNC L+ N Q + DKD GD CDNC V N Q DTD +G GDAC D+DGD
Sbjct: 514 DGILNEQDNCVLIHNVDQRNSDKDIFGDACDNCLSVLNNDQKDTDGDGRGDACDDDMDGD 573
Query: 807 DVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTDVDNDLVGDQCDNNEDIDD 866
+ N DNCP N DQRD DGDGVGD CD+CP V NP+Q+DVDNDLVGD CD N+D D
Sbjct: 574 GIKNILDNCPKFPNRDQRDKDGDGVGDACDSCPDVSNPNQSDVDNDLVGDSCDTNQDSDG 633
Query: 867 DGHQNNQDNCPYISNANQADHDRDGQGDACDPDDDNDGVPD----DRDNCRLVFNPDQED 922
DGHQ++ DNCP + N+ Q D D+DG GD CD DDDNDG+PD DNCRLV NP QED
Sbjct: 634 DGHQDSTDNCPTVINSAQLDTDKDGIGDECDDDDDNDGIPDLVPPGPDNCRLVPNPAQED 693
Query: 923 LDGDGRGDICKDDFDNDNIPDIDDVCPENNAISETDFRNFQMVPLDPKGTTQIDPNWVIR 982
+ DG GDIC+ DFD D + D DVCPEN ++ TDFR +Q V LDP+G QIDPNWV+
Sbjct: 694 SNSDGVGDICESDFDQDQVIDRIDVCPENAEVTLTDFRAYQTVVLDPEGDAQIDPNWVVL 753
Query: 983 HQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMW 1042
+QG E+VQT NSDPG+AVG+ F VDF GTF+VNT DDDYAGF+FGYQ SS FYVVMW
Sbjct: 754 NQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTQTDDDYAGFIFGYQDSSSFYVVMW 813
Query: 1043 KQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPRNI 1102
KQ QTYW+ P RA G+ LK V S TG GEHLRN+LWHTG+T QVR LW D RN+
Sbjct: 814 KQTEQTYWQATPFRAVAEPGIQLKAVKSKTGPGEHLRNSLWHTGDTSDQVRLLWKDSRNV 873
Query: 1103 GWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMVYF 1162
GWKD +YRW L HRP+ GYIRV +EG +++ADSG D T GGRLG+F FSQE + +
Sbjct: 874 GWKDKVSYRWFLQHRPQVGYIRVRFYEGSELVADSGVTIDTTMRGGRLGVFCFSQENIIW 933
Query: 1163 SDLKYECRD 1171
S+LKY C D
Sbjct: 934 SNLKYRCND 942
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 178 bits (452), Expect = 2e-44
Identities = 88/232 (37%), Positives = 120/232 (51%), Gaps = 20/232 (8%)
Query: 333 WVVDSCTTCTC----KKFKTICHQITCPPATCASP---SFVEGECCPSCLHSVDGEEGWS 385
W + TC +K +C+Q PA P S +E C + VDG WS
Sbjct: 4535 WSAWRACSVTCGKGIQKRSRLCNQPL--PANGGKPCQGSDLEMRNCQNKPCPVDGS--WS 4590
Query: 386 PWAEWTQCSVTCGSGTQQRGRSCDVTS-----NTCLGPSIQTRACSLSKCDTRIRQDGGW 440
W+ W +C+ +CG G Q R R+C+ S C G +++ C++ C G W
Sbjct: 4591 EWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPCPVH----GAW 4646
Query: 441 SHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRWSPW 500
S W PW +CS +CG G TR RLCN+P P GG C G+ + + C CPI G+W+ W
Sbjct: 4647 SAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERNCPIHGKWATW 4706
Query: 501 SPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVDG 552
+ WSAC+V+C GG R+RTR C+ P PQYGG+ C G + CN CP G
Sbjct: 4707 ASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGSDVQSDFCNSDPCPTHG 4758
Score = 174 bits (442), Expect = 3e-43
Identities = 74/175 (42%), Positives = 98/175 (56%), Gaps = 9/175 (5%)
Query: 383 GWSPWAEWTQCSVTCGSGTQQRGRSCDVT-----SNTCLGPSIQTRACSLSKCDTRIRQD 437
G+S W+ W CSVTCG G Q+R R C+ C G ++ R C C D
Sbjct: 4531 GFSQWSAWRACSVTCGKGIQKRSRLCNQPLPANGGKPCQGSDLEMRNCQNKPCPV----D 4586
Query: 438 GGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRW 497
G WS WS W C+ +CG GN TR R CN+P Q GG+ C+G+ E C PCP+ G W
Sbjct: 4587 GSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPCPVHGAW 4646
Query: 498 SPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVDG 552
S W PW C+ +C G + R R+CN+P P +GG C G + Q+CN+R+CP+ G
Sbjct: 4647 SAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERNCPIHG 4701
Score = 171 bits (432), Expect = 5e-42
Identities = 82/197 (41%), Positives = 104/197 (52%), Gaps = 16/197 (8%)
Query: 384 WSPWAEWTQCSVTCGSGTQQRGRSCD-----VTSNTCLGPSIQTRACSLSKCDTRIRQDG 438
WS W W CS +CG GTQ R R C+ + C G Q + C+ C G
Sbjct: 4646 WSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERNCPIH----G 4701
Query: 439 GWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRWS 498
W+ W+ WS+CSV+CG G R R C+ PVPQ GG+ C+GS ++ C PCP G WS
Sbjct: 4702 KWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGSDVQSDFCNSDPCPTHGNWS 4761
Query: 499 PWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVDGCLSNPC 558
PWS W C+ TC GG R R C++P P GG+AC G + Q CN CPVDG +
Sbjct: 4762 PWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQRCNTDMCPVDGSWGS-W 4820
Query: 559 FPGAQCSSFPDGSWSCG 575
+QCS+ SCG
Sbjct: 4821 HSWSQCSA------SCG 4831
Score = 160 bits (405), Expect = 7e-39
Identities = 67/171 (39%), Positives = 91/171 (53%), Gaps = 9/171 (5%)
Query: 384 WSPWAEWTQCSVTCGSGTQQRGRSCD-----VTSNTCLGPSIQTRACSLSKCDTRIRQDG 438
W+ WA W+ CSV+CG G +QR R C C G +Q+ C+ C T G
Sbjct: 4703 WATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGSDVQSDFCNSDPCPTH----G 4758
Query: 439 GWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRWS 498
WS WS W +CS TC G + R R C++P P GG+ C G + + C CP+DG W
Sbjct: 4759 NWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQRCNTDMCPVDGSWG 4818
Query: 499 PWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCP 549
W WS C+ +C GG + R R+C+ P P GG+ C GD + CN ++CP
Sbjct: 4819 SWHSWSQCSASCGGGEKTRKRLCDHPVPVKGGRPCPGDTTQVTRCNVQACP 4869
Score = 149 bits (377), Expect = 1e-35
Identities = 74/161 (45%), Positives = 94/161 (58%), Gaps = 8/161 (4%)
Query: 434 IRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCPI 493
++ GG+S WS W +CSVTCG G R RLCN P+P GGK C+GS E + CQ PCP+
Sbjct: 4526 VQVHGGFSQWSAWRACSVTCGKGIQKRSRLCNQPLPANGGKPCQGSDLEMRNCQNKPCPV 4585
Query: 494 DGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVDGC 553
DG WS WS W CT +C G + RTR CN+P Q+GG+ C G+ E MCN R CPV G
Sbjct: 4586 DGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPCPVHGA 4645
Query: 554 LSNPCFPGAQCS-SFPDGSWS----CGSCPVGFLGNGTHCE 589
S P CS S G+ + C + P F G++C+
Sbjct: 4646 WS-AWQPWGTCSESCGKGTQTRARLCNNPPPAF--GGSYCD 4683
Score = 55.5 bits (132), Expect = 3e-07
Identities = 56/229 (24%), Positives = 83/229 (36%), Gaps = 55/229 (24%)
Query: 506 CTVTCAGGIRERTRVCNSPEPQYGGKAC--VGDVQERQMCNKRSCPVDGCLSNPCFPGAQ 563
C V C G R + G +C + + QE C++R CF
Sbjct: 5173 CVVRCGSGFRRTS----------DGLSCQDINECQESSPCHQR-----------CFNAI- 5210
Query: 564 CSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHCLPCP 623
GS+ CG C G+ G C D++EC ++C C NT+ G+ C+
Sbjct: 5211 ------GSFHCG-CEPGYQLKGRKCMDVNECR--QNVCRPDQ---HCKNTRGGYKCIDLC 5258
Query: 624 PRYRGNQPVGVGLEAAKTEKQVCEPENPCKDKTHNCHKHAECIYLGHFSDPMYKCECQTG 683
P K E C + CKD TH C + C + Y+C C G
Sbjct: 5259 PN-----------GMTKAENGTCIDIDECKDGTHQCRYNQIC----ENTRGSYRCVCPRG 5303
Query: 684 Y--AGDGLICGEDSDLDGWPN--LNLVCATNATYHCIKDNCPHLPNSGQ 728
Y G G C + ++ + P + T ++ CI HL G+
Sbjct: 5304 YRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGK 5352
Score = 43.9 bits (102), Expect = 0.001
Identities = 68/270 (25%), Positives = 94/270 (34%), Gaps = 60/270 (22%)
Query: 551 DGCLS-NPCFPGAQCSSFPDGSWSCGSCPVGFL--GNGTHCEDLDECALVPDICFSTSKV 607
D C + NPC + G++ C SCP G +G C+D+DECAL C +
Sbjct: 5109 DECAAGNPCSHSCHNAM---GTYYC-SCPKGLTIAADGRTCQDIDECALGRHTCHAGQD- 5163
Query: 608 PRCVNTQPGFHC-LPCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCKDKTHNCHKHAECI 666
C NT + C + C +R GL + C+ +PC + N
Sbjct: 5164 --CDNTIGSYRCVVRCGSGFRRTSD---GLSCQDINE--CQESSPCHQRCFNA------- 5209
Query: 667 YLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNLNLVCA-------TNATYHCIKDN 719
+G F C C+ GY G C + ++ VC T Y CI D
Sbjct: 5210 -IGSF-----HCGCEPGYQLKGRKCMDVNEC-----RQNVCRPDQHCKNTRGGYKCI-DL 5257
Query: 720 CPHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQA-------DYDKDEV 772
CP+ K G D D+ DG + N Q+ N R + Y V
Sbjct: 5258 CPN-------GMTKAENGTCIDIDECKDGTHQCRYN-QICENTRGSYRCVCPRGYRSQGV 5309
Query: 773 GDRC---DNCPYVHNPAQIDTDNNGEGDAC 799
G C + C V P N C
Sbjct: 5310 GRPCMDINECEQVPKPCAHQCSNTPGSFKC 5339
Score = 40.0 bits (92), Expect = 0.013
Identities = 24/72 (33%), Positives = 39/72 (54%), Gaps = 8/72 (11%)
Query: 570 GSWSCGSCPVGF--LGNGTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHCL--PCPPR 625
GS+ C CP G+ NG C+D+DEC L ++ +++ C N + + C+ PCPP
Sbjct: 5451 GSYQC-ICPPGYQLTHNGKTCQDIDEC-LEQNVHCGPNRM--CFNMRGSYQCIDTPCPPN 5506
Query: 626 YRGNQPVGVGLE 637
Y+ + G L+
Sbjct: 5507 YQRDPVSGFCLK 5518
Score = 31.6 bits (70), Expect = 4.6
Identities = 22/90 (24%), Positives = 35/90 (38%), Gaps = 18/90 (20%)
Query: 576 SCPVGFLGNGTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHCLPCPPRYRGNQPVGVG 635
+CP G + C D+DEC D C C NT + C+ CPP Y+
Sbjct: 5418 TCPEGSEASHDTCVDIDECENT-DAC-----QHECKNTFGSYQCI-CPPGYQ-------- 5462
Query: 636 LEAAKTEKQVCEPENPCKDKTHNCHKHAEC 665
+ C+ + C ++ +C + C
Sbjct: 5463 ---LTHNGKTCQDIDECLEQNVHCGPNRMC 5489
>gi|111118994 brain-specific angiogenesis inhibitor 1 precursor
[Homo sapiens]
Length = 1584
Score = 160 bits (404), Expect = 9e-39
Identities = 76/193 (39%), Positives = 102/193 (52%), Gaps = 10/193 (5%)
Query: 360 CASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSC---DVTSNTCL 416
C+ P + C S + V G W W+ W+ CS TCG G + R R+C N C
Sbjct: 390 CSGPLREQRLCNNSAVCPVHG--AWDEWSPWSLCSSTCGRGFRDRTRTCRPPQFGGNPCE 447
Query: 417 GPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNC 476
GP QT+ C+++ C R DG W+ WS WS+CS +C G R R CN P GG C
Sbjct: 448 GPEKQTKFCNIALCPGRA-VDGNWNEWSSWSACSASCSQGRQQRTRECNGP--SYGGAEC 504
Query: 477 KGSGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGD 536
+G ET+ C CP+DG+W W+ W +C+VTC G + R RVC+ P +GG AC G
Sbjct: 505 QGHWVETRDCFLQQCPVDGKWQAWASWGSCSVTCGAGSQRRERVCSG--PFFGGAACQGP 562
Query: 537 VQERQMCNKRSCP 549
E + C + CP
Sbjct: 563 QDEYRQCGTQRCP 575
Score = 154 bits (388), Expect = 6e-37
Identities = 89/231 (38%), Positives = 107/231 (46%), Gaps = 40/231 (17%)
Query: 380 GEEGWSPWAEWTQCSVTCGSGTQQRGRSC--DVTSNTCLGPSIQTRACSLSK-CDTRIRQ 436
G+ W+ W+ CS TCG G Q R R C S C GP + R C+ S C
Sbjct: 353 GDPAAEEWSPWSVCSSTCGEGWQTRTRFCVSSSYSTQCSGPLREQRLCNNSAVCPVH--- 409
Query: 437 DGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCP---I 493
G W WSPWS CS TCG G R R C PQ GG C+G ++TK C A CP +
Sbjct: 410 -GAWDEWSPWSLCSSTCGRGFRDRTRTCRP--PQFGGNPCEGPEKQTKFCNIALCPGRAV 466
Query: 494 DGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVDG- 552
DG W+ WS WSAC+ +C+ G ++RTR CN P YGG C G E + C + CPVDG
Sbjct: 467 DGNWNEWSSWSACSASCSQGRQQRTRECNG--PSYGGAECQGHWVETRDCFLQQCPVDGK 524
Query: 553 -----------------------CLSNPCFPGAQCSSFPDGSWSCGS--CP 578
S P F GA C D CG+ CP
Sbjct: 525 WQAWASWGSCSVTCGAGSQRRERVCSGPFFGGAACQGPQDEYRQCGTQRCP 575
Score = 127 bits (320), Expect = 5e-29
Identities = 75/211 (35%), Positives = 91/211 (43%), Gaps = 46/211 (21%)
Query: 383 GWSPWAEWTQCSVTCGSGTQQRGRSC----DVTSNTCLGPSIQTRACSLSKC-------- 430
GW W+ W +C+ CG G Q R R+C V C G + R C+ C
Sbjct: 263 GWKLWSLWGECTRDCGGGLQTRTRTCLPAPGVEGGGCEGVLEEGRQCNREACGPAGRTSS 322
Query: 431 --------DTRIRQDGG-----------------WSHWSPWSSCSVTCGVGNITRIRLCN 465
D R R++ G WSPWS CS TCG G TR R C
Sbjct: 323 RSQSLRSTDARRREELGDELQQFGFPAPQTGDPAAEEWSPWSVCSSTCGEGWQTRTRFC- 381
Query: 466 SPVPQMGGKNCKGSGRETKAC-QGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSP 524
V C G RE + C A CP+ G W WSPWS C+ TC G R+RTR C
Sbjct: 382 --VSSSYSTQCSGPLREQRLCNNSAVCPVHGAWDEWSPWSLCSSTCGRGFRDRTRTCR-- 437
Query: 525 EPQYGGKACVGDVQERQMCNKRSCP---VDG 552
PQ+GG C G ++ + CN CP VDG
Sbjct: 438 PPQFGGNPCEGPEKQTKFCNIALCPGRAVDG 468
Score = 78.6 bits (192), Expect = 3e-14
Identities = 63/205 (30%), Positives = 80/205 (39%), Gaps = 57/205 (27%)
Query: 430 CDTRIRQD-------GGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRE 482
C T + QD GGW WS W C+ CG G TR R C P P + G C+G E
Sbjct: 247 CLTSLTQDRGGHGATGGWKLWSLWGECTRDCGGGLQTRTRTC-LPAPGVEGGGCEGVLEE 305
Query: 483 TKACQGAPCPIDGRWS-------------------------------------PWSPWSA 505
+ C C GR S WSPWS
Sbjct: 306 GRQCNREACGPAGRTSSRSQSLRSTDARRREELGDELQQFGFPAPQTGDPAAEEWSPWSV 365
Query: 506 CTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRS-CPVDGCLSNPCFPGAQC 564
C+ TC G + RTR C S C G ++E+++CN + CPV G + P + C
Sbjct: 366 CSSTCGEGWQTRTRFCVSSS---YSTQCSGPLREQRLCNNSAVCPVHGAW-DEWSPWSLC 421
Query: 565 SS-----FPDGSWSCGSCPVGFLGN 584
SS F D + +C P F GN
Sbjct: 422 SSTCGRGFRDRTRTCR--PPQFGGN 444
Score = 59.7 bits (143), Expect = 2e-08
Identities = 31/85 (36%), Positives = 42/85 (49%), Gaps = 5/85 (5%)
Query: 472 GGKNCKGSGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGK 531
G +NC S + + GA G W WS W CT C GG++ RTR C P P G
Sbjct: 243 GPENCLTSLTQDRGGHGAT----GGWKLWSLWGECTRDCGGGLQTRTRTC-LPAPGVEGG 297
Query: 532 ACVGDVQERQMCNKRSCPVDGCLSN 556
C G ++E + CN+ +C G S+
Sbjct: 298 GCEGVLEEGRQCNREACGPAGRTSS 322
>gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens]
Length = 1522
Score = 157 bits (397), Expect = 6e-38
Identities = 86/218 (39%), Positives = 111/218 (50%), Gaps = 14/218 (6%)
Query: 380 GEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNT-CLGPSIQTRACS-LSKCDTRIRQD 437
GE G W++W+ CSVTCG G+Q R R+C T C GP ++R C+ + C
Sbjct: 290 GESGVEEWSQWSTCSVTCGQGSQVRTRTCVSPYGTHCSGPLRESRVCNNTALCPVH---- 345
Query: 438 GGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRW 497
G W WSPWS CS TCG G TR R C P Q GG+ C+G K C A CP+DG+W
Sbjct: 346 GVWEEWSPWSLCSFTCGRGQRTRTRSCTPP--QYGGRPCEGPETHHKPCNIALCPVDGQW 403
Query: 498 SPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVDGCLSNP 557
WS WS C+VTC+ G ++R+R C + +GG C G E + C C +G N
Sbjct: 404 QEWSSWSQCSVTCSNGTQQRSRQCTA--AAHGGSECRGPWAESRECYNPECTANG-QWNQ 460
Query: 558 CFPGAQCSSFPDGSWS--CGSCPVGFLGNGTHCEDLDE 593
+ CS DG W +C G + G CE E
Sbjct: 461 WGHWSGCSKSCDGGWERRIRTCQ-GAVITGQQCEGTGE 497
Score = 103 bits (256), Expect = 1e-21
Identities = 58/169 (34%), Positives = 80/169 (47%), Gaps = 16/169 (9%)
Query: 331 ETWVVDSCTTCTCKKFKTICHQITCPPA----TCASPSFVEGECCPSCLHSVDGEEGWSP 386
E W S + TC + + + PP C P + C L VDG+ W
Sbjct: 349 EEWSPWSLCSFTCGRGQRTRTRSCTPPQYGGRPCEGPE-THHKPCNIALCPVDGQ--WQE 405
Query: 387 WAEWTQCSVTCGSGTQQRGRSCDVTSN---TCLGPSIQTRACSLSKCDTRIRQDGGWSHW 443
W+ W+QCSVTC +GTQQR R C ++ C GP ++R C +C +G W+ W
Sbjct: 406 WSSWSQCSVTCSNGTQQRSRQCTAAAHGGSECRGPWAESRECYNPECTA----NGQWNQW 461
Query: 444 SPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCP 492
WS CS +C G RIR C V + G+ C+G+G E + C CP
Sbjct: 462 GHWSGCSKSCDGGWERRIRTCQGAV--ITGQQCEGTGEEVRRCSEQRCP 508
>gi|4505737 complement factor properdin precursor [Homo sapiens]
Length = 469
Score = 149 bits (376), Expect = 2e-35
Identities = 78/194 (40%), Positives = 94/194 (48%), Gaps = 18/194 (9%)
Query: 369 ECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLS 428
+CCP GWS W W CSVTC GT+ R R+C+ + C G +A
Sbjct: 131 QCCPEM-------GGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKC-GGHCPGQAQESE 182
Query: 429 KCDTR--IRQDGGWSHWSPWSSCSVTCGVG----NITRIRLCNSPVPQMG--GKNCKGSG 480
CDT+ G W+ W PW+ CS +C G TR R C++P P GK C G
Sbjct: 183 ACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLA 242
Query: 481 RETKACQGAP-CPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQE 539
E + C G P CP+ G W PW P S C VTC G R CN P PQ+GG C GD
Sbjct: 243 YEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATR 302
Query: 540 RQMCNKR-SCPVDG 552
+CN CPVDG
Sbjct: 303 THICNTAVPCPVDG 316
Score = 144 bits (363), Expect = 5e-34
Identities = 75/183 (40%), Positives = 95/183 (51%), Gaps = 18/183 (9%)
Query: 384 WSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGP------SIQTRACSLSKCDTRIRQD 437
WS W+ W CSVTC G+Q R R C + C G Q +AC +C +
Sbjct: 80 WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEM--- 136
Query: 438 GGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAP-CPIDGR 496
GGWS W PW CSVTC G TR R CN P P+ GG +C G +E++AC CP G
Sbjct: 137 GGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGG-HCPGQAQESEACDTQQVCPTHGA 195
Query: 497 WSPWSPWSACTVTCAGGIRE----RTRVCNSPEPQY--GGKACVGDVQERQMC-NKRSCP 549
W+ W PW+ C+ +C GG E R+R C++PEP GK C G E++ C CP
Sbjct: 196 WATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCP 255
Query: 550 VDG 552
V G
Sbjct: 256 VAG 258
Score = 120 bits (301), Expect = 8e-27
Identities = 72/223 (32%), Positives = 95/223 (42%), Gaps = 35/223 (15%)
Query: 355 CPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQ----RGRSCDV 410
CP S + + CP+ W+ W WT CS +C G + R R C
Sbjct: 174 CPGQAQESEACDTQQVCPT-------HGAWATWGPWTPCSASCHGGPHEPKETRSRKCSA 226
Query: 411 TSNT-------CLGPSIQTRACS-LSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIR 462
+ C G + + R C+ L C GGW W P S C VTCG+G R
Sbjct: 227 PEPSQKPPGKPCPGLAYEQRRCTGLPPCPVA----GGWGPWGPVSPCPVTCGLGQTMEQR 282
Query: 463 LCNSPVPQMGGKNCKGSGRETKACQGA-PCPIDGRWSPWSPWSAC------TVTC--AGG 513
CN PVPQ GG C G T C A PCP+DG W W WS C +++C G
Sbjct: 283 TCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPG 342
Query: 514 IRERTRVCNSPEPQYGGKACVGDVQERQMC-NKRSCPVDGCLS 555
+ R R C ++ G C G Q+ + C + + CP+ G S
Sbjct: 343 QQSRGRTCRG--RKFDGHRCAGQQQDIRHCYSIQHCPLKGSWS 383
Score = 84.7 bits (208), Expect = 5e-16
Identities = 57/187 (30%), Positives = 75/187 (40%), Gaps = 20/187 (10%)
Query: 356 PPATCASPSFVEGECC--PSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSN 413
P C ++ + C P C V G GW PW + C VTCG G R+C+
Sbjct: 234 PGKPCPGLAYEQRRCTGLPPC--PVAG--GWGPWGPVSPCPVTCGLGQTMEQRTCNHPVP 289
Query: 414 TCLGPSIQTRACSLSKCDTRIR--QDGGWSHWSPWSSC------SVTCGV--GNITRIRL 463
GP A C+T + DG W W WS C S++C G +R R
Sbjct: 290 QHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRT 349
Query: 464 CNSPVPQMGGKNCKGSGRETKACQGAP-CPIDGRWSPWSPWSACTVTCA-GGIRERTRVC 521
C + G C G ++ + C CP+ G WS WS W C C R R R+C
Sbjct: 350 CRGR--KFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLC 407
Query: 522 NSPEPQY 528
P+Y
Sbjct: 408 TPLLPKY 414
Score = 46.2 bits (108), Expect = 2e-04
Identities = 24/64 (37%), Positives = 32/64 (50%), Gaps = 4/64 (6%)
Query: 486 CQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQ-ERQMCN 544
CQ P RWS WS W+ C+VTC+ G + R R C Q GK G ++ + Q C
Sbjct: 72 CQPCRSP---RWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACE 128
Query: 545 KRSC 548
+ C
Sbjct: 129 DQQC 132
>gi|223671861 complement factor properdin precursor [Homo sapiens]
Length = 469
Score = 149 bits (376), Expect = 2e-35
Identities = 78/194 (40%), Positives = 94/194 (48%), Gaps = 18/194 (9%)
Query: 369 ECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLS 428
+CCP GWS W W CSVTC GT+ R R+C+ + C G +A
Sbjct: 131 QCCPEM-------GGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKC-GGHCPGQAQESE 182
Query: 429 KCDTR--IRQDGGWSHWSPWSSCSVTCGVG----NITRIRLCNSPVPQMG--GKNCKGSG 480
CDT+ G W+ W PW+ CS +C G TR R C++P P GK C G
Sbjct: 183 ACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLA 242
Query: 481 RETKACQGAP-CPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQE 539
E + C G P CP+ G W PW P S C VTC G R CN P PQ+GG C GD
Sbjct: 243 YEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATR 302
Query: 540 RQMCNKR-SCPVDG 552
+CN CPVDG
Sbjct: 303 THICNTAVPCPVDG 316
Score = 144 bits (363), Expect = 5e-34
Identities = 75/183 (40%), Positives = 95/183 (51%), Gaps = 18/183 (9%)
Query: 384 WSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGP------SIQTRACSLSKCDTRIRQD 437
WS W+ W CSVTC G+Q R R C + C G Q +AC +C +
Sbjct: 80 WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEM--- 136
Query: 438 GGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAP-CPIDGR 496
GGWS W PW CSVTC G TR R CN P P+ GG +C G +E++AC CP G
Sbjct: 137 GGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGG-HCPGQAQESEACDTQQVCPTHGA 195
Query: 497 WSPWSPWSACTVTCAGGIRE----RTRVCNSPEPQY--GGKACVGDVQERQMC-NKRSCP 549
W+ W PW+ C+ +C GG E R+R C++PEP GK C G E++ C CP
Sbjct: 196 WATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCP 255
Query: 550 VDG 552
V G
Sbjct: 256 VAG 258
Score = 120 bits (301), Expect = 8e-27
Identities = 72/223 (32%), Positives = 95/223 (42%), Gaps = 35/223 (15%)
Query: 355 CPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQ----RGRSCDV 410
CP S + + CP+ W+ W WT CS +C G + R R C
Sbjct: 174 CPGQAQESEACDTQQVCPT-------HGAWATWGPWTPCSASCHGGPHEPKETRSRKCSA 226
Query: 411 TSNT-------CLGPSIQTRACS-LSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIR 462
+ C G + + R C+ L C GGW W P S C VTCG+G R
Sbjct: 227 PEPSQKPPGKPCPGLAYEQRRCTGLPPCPVA----GGWGPWGPVSPCPVTCGLGQTMEQR 282
Query: 463 LCNSPVPQMGGKNCKGSGRETKACQGA-PCPIDGRWSPWSPWSAC------TVTC--AGG 513
CN PVPQ GG C G T C A PCP+DG W W WS C +++C G
Sbjct: 283 TCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPG 342
Query: 514 IRERTRVCNSPEPQYGGKACVGDVQERQMC-NKRSCPVDGCLS 555
+ R R C ++ G C G Q+ + C + + CP+ G S
Sbjct: 343 QQSRGRTCRG--RKFDGHRCAGQQQDIRHCYSIQHCPLKGSWS 383
Score = 84.7 bits (208), Expect = 5e-16
Identities = 57/187 (30%), Positives = 75/187 (40%), Gaps = 20/187 (10%)
Query: 356 PPATCASPSFVEGECC--PSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSN 413
P C ++ + C P C V G GW PW + C VTCG G R+C+
Sbjct: 234 PGKPCPGLAYEQRRCTGLPPC--PVAG--GWGPWGPVSPCPVTCGLGQTMEQRTCNHPVP 289
Query: 414 TCLGPSIQTRACSLSKCDTRIR--QDGGWSHWSPWSSC------SVTCGV--GNITRIRL 463
GP A C+T + DG W W WS C S++C G +R R
Sbjct: 290 QHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRT 349
Query: 464 CNSPVPQMGGKNCKGSGRETKACQGAP-CPIDGRWSPWSPWSACTVTCA-GGIRERTRVC 521
C + G C G ++ + C CP+ G WS WS W C C R R R+C
Sbjct: 350 CRGR--KFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLC 407
Query: 522 NSPEPQY 528
P+Y
Sbjct: 408 TPLLPKY 414
Score = 46.2 bits (108), Expect = 2e-04
Identities = 24/64 (37%), Positives = 32/64 (50%), Gaps = 4/64 (6%)
Query: 486 CQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQ-ERQMCN 544
CQ P RWS WS W+ C+VTC+ G + R R C Q GK G ++ + Q C
Sbjct: 72 CQPCRSP---RWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACE 128
Query: 545 KRSC 548
+ C
Sbjct: 129 DQQC 132
>gi|115387099 brain-specific angiogenesis inhibitor 2 [Homo sapiens]
Length = 1585
Score = 145 bits (365), Expect = 3e-34
Identities = 72/204 (35%), Positives = 101/204 (49%), Gaps = 11/204 (5%)
Query: 372 PSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVT--SNTCLGPSIQTRACSLSK 429
P + G+ W+ W+ CS+TCG G Q R RSC + C GP +TR C+ S
Sbjct: 300 PGLYMAQTGDPAAEEWSPWSVCSLTCGQGLQVRTRSCVSSPYGTLCSGPLRETRPCNNSA 359
Query: 430 -CDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQG 488
C G W W WS CS +CG G+ +R+R C P Q GGK C+G +TK C
Sbjct: 360 TCPVH----GVWEEWGSWSLCSRSCGRGSRSRMRTCVPP--QHGGKACEGPELQTKLCSM 413
Query: 489 APCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSC 548
A CP++G+W W PW C+ +CA G ++R+R C+ P + C G + + + C+ C
Sbjct: 414 AACPVEGQWLEWGPWGPCSTSCANGTQQRSRKCSVAGPAWA--TCTGALTDTRECSNLEC 471
Query: 549 PVDGCLSNPCFPGAQCSSFPDGSW 572
P P + CS D W
Sbjct: 472 PATDSKWGPWNAWSLCSKTCDTGW 495
Score = 129 bits (325), Expect = 1e-29
Identities = 72/226 (31%), Positives = 106/226 (46%), Gaps = 17/226 (7%)
Query: 331 ETWVVDSCTTCTCKKFKTICHQ--ITCPPAT-CASPSFVEGECCPSCLHSVDGEEGWSPW 387
E W S + TC + + + ++ P T C+ P C S V G W W
Sbjct: 313 EEWSPWSVCSLTCGQGLQVRTRSCVSSPYGTLCSGPLRETRPCNNSATCPVHGV--WEEW 370
Query: 388 AEWTQCSVTCGSGTQQRGRSCDVTSN---TCLGPSIQTRACSLSKCDTRIRQDGGWSHWS 444
W+ CS +CG G++ R R+C + C GP +QT+ CS++ C +G W W
Sbjct: 371 GSWSLCSRSCGRGSRSRMRTCVPPQHGGKACEGPELQTKLCSMAACPV----EGQWLEWG 426
Query: 445 PWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCPI-DGRWSPWSPW 503
PW CS +C G R R C+ P C G+ +T+ C CP D +W PW+ W
Sbjct: 427 PWGPCSTSCANGTQQRSRKCSVAGPAWA--TCTGALTDTRECSNLECPATDSKWGPWNAW 484
Query: 504 SACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCP 549
S C+ TC G + R R+C + Q G C G +E + C+++ CP
Sbjct: 485 SLCSKTCDTGWQRRFRMCQATGTQ--GYPCEGTGEEVKPCSEKRCP 528
>gi|147904700 semaphorin 5A [Homo sapiens]
Length = 1074
Score = 133 bits (334), Expect = 1e-30
Identities = 67/181 (37%), Positives = 89/181 (49%), Gaps = 12/181 (6%)
Query: 371 CPSCLHSVDGEEG-WSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLSK 429
CP+ +VDG G WSPW T + R RSCD + C G + ++
Sbjct: 532 CPTRNLTVDGHFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGPGMEIAN 591
Query: 430 CDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKAC-QG 488
C ++GGW+ W+ WS CS TCG+G R R C++P P+ GG+ C G RE + C +
Sbjct: 592 CS----RNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEH 647
Query: 489 APCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSC 548
CP W+ W PW CT C GGI+ R R+C + G C G E Q CN C
Sbjct: 648 LLCPPHMFWTGWGPWERCTAQCGGGIQARRRICEN------GPDCAGCNVEYQSCNTNPC 701
Query: 549 P 549
P
Sbjct: 702 P 702
Score = 133 bits (334), Expect = 1e-30
Identities = 69/189 (36%), Positives = 91/189 (48%), Gaps = 24/189 (12%)
Query: 385 SPWAEWTQCSVTCGSGTQQ-------RGRSCDVTSNTCLGPSIQTRACS---LSKCDTR- 433
+PW WT +++ G + + R D I+ R CS S C T
Sbjct: 708 TPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDGTSGCSTDG 767
Query: 434 -----IRQ--------DGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSG 480
+R +G WS W+ WS CS C G R R+CN+P P+ GG C G
Sbjct: 768 LSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPS 827
Query: 481 RETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQER 540
E + C PCP+DG WS WSPW+ C+ TC GG RTR C++P P YGG C+G E
Sbjct: 828 LEYQECNILPCPVDGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEE 887
Query: 541 QMCNKRSCP 549
+CN + CP
Sbjct: 888 ALCNTQPCP 896
Score = 131 bits (329), Expect = 4e-30
Identities = 68/173 (39%), Positives = 86/173 (49%), Gaps = 18/173 (10%)
Query: 376 HSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCD-----VTSNTCLGPSIQTRACSLSKC 430
H+V+G WS W W+QCS C G + R R C+ CLGPS++ + C++ C
Sbjct: 781 HTVNG--AWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPSLEYQECNILPC 838
Query: 431 DTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAP 490
DG WS WSPW+ CS TCG G+ R R C++P P GG C G E C P
Sbjct: 839 PV----DGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQP 894
Query: 491 CPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMC 543
CP WS WS WS C A G++ R R C P G C G+ E + C
Sbjct: 895 CPES--WSEWSDWSECE---ASGVQVRARQCILLFPM--GSQCSGNTTESRPC 940
Score = 119 bits (298), Expect = 2e-26
Identities = 77/257 (29%), Positives = 114/257 (44%), Gaps = 43/257 (16%)
Query: 384 WSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHW 443
W+ W W +C+ CG G Q R R C+ C G +++ ++C+ + C +++ W+ W
Sbjct: 656 WTGWGPWERCTAQCGGGIQARRRICE-NGPDCAGCNVEYQSCNTNPCP-ELKKTTPWTPW 713
Query: 444 SPWS--------------SCSVTCGVGNITRI-------RLCNSPVPQMGGKNCKG---S 479
+P + +C N+ + R C+S G C S
Sbjct: 714 TPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSD----GTSGCSTDGLS 769
Query: 480 GRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQE 539
G +A + + ++G WS W+ WS C+ C+ GIR R RVCN+PEP+YGG C+G E
Sbjct: 770 GDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPSLE 829
Query: 540 RQMCNKRSCPVDGCLSNPCF-PGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVP 598
Q CN CPVDG S C+ P +CS+ +C G C + A
Sbjct: 830 YQECNILPCPVDGVWS--CWSPWTKCSA---------TCGGGHYMRTRSCSN-PAPAYGG 877
Query: 599 DICFSTSKVPRCVNTQP 615
DIC NTQP
Sbjct: 878 DICLGLHTEEALCNTQP 894
Score = 113 bits (283), Expect = 9e-25
Identities = 68/187 (36%), Positives = 96/187 (51%), Gaps = 31/187 (16%)
Query: 426 SLSKCDTR-IRQDGGWSHWSPWSSCSVTCG--VGN-ITRIRLCNSPVPQMGGKNCKGSGR 481
S+S C TR + DG + WSPW+ C+ T G VG+ + R R C+SP PQ GG C+G G
Sbjct: 528 SISACPTRNLTVDGHFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGPGM 587
Query: 482 ETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQ 541
E A C +G W+PW+ WS C+ TC G + R R C++P P++GG+ CVG +E +
Sbjct: 588 EI-----ANCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREER 642
Query: 542 MCNKRSC-----------PVDGCLSNPCFPGAQ-----CSSFPDGSWSCGSCPVGFLGNG 585
CN+ P + C + C G Q C + PD C C V +
Sbjct: 643 YCNEHLLCPPHMFWTGWGPWERCTAQ-CGGGIQARRRICENGPD----CAGCNVEYQSCN 697
Query: 586 TH-CEDL 591
T+ C +L
Sbjct: 698 TNPCPEL 704
Score = 98.6 bits (244), Expect = 3e-20
Identities = 91/378 (24%), Positives = 138/378 (36%), Gaps = 83/378 (21%)
Query: 340 TCTCKKFKTICHQITCPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGS 399
+C C+ C C P C S +G GW+PW W+ CS TCG
Sbjct: 562 SCLCRTRSCDSPAPQCGGWQCEGPGMEIANC------SRNG--GWTPWTSWSPCSTTCGI 613
Query: 400 GTQQRGRSCDVTS-----NTCLGPSIQTRACSLS-KCDTRIRQDGGWSHWSPWSSCSVTC 453
G Q R RSC + C+G + + R C+ C + W+ W PW C+ C
Sbjct: 614 GFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLLCPPHM----FWTGWGPWERCTAQC 669
Query: 454 GVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGG 513
G G R R+C + G +C G E ++C PCP + +PW+PW+ ++ GG
Sbjct: 670 GGGIQARRRICEN------GPDCAGCNVEYQSCNTNPCPELKKTTPWTPWTPVNISDNGG 723
Query: 514 IRERTRVCNSPEPQYGGKACVGDVQ---------ERQMCNK---RSCPVDGCLSNPCFPG 561
E+ +Y KA + D E + C+ C DG + G
Sbjct: 724 HYEQ-------RFRYTCKARLADPNLLEVGRQRIEMRYCSSDGTSGCSTDGLSGDFLRAG 776
Query: 562 AQCSSFPDGSWSCGS--------CPVGFLGNGTHCE----------------DLDECALV 597
+ +G+WS + C G C + EC ++
Sbjct: 777 RYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPSLEYQECNIL 836
Query: 598 P----DICFSTSKVPRCVNTQPGFH------CLPCPPRYRGNQPVGVGLEAAKTEKQVCE 647
P + S +C T G H C P Y G+ +G+ TE+ +C
Sbjct: 837 PCPVDGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGL-----HTEEALCN 891
Query: 648 PENPCKDKTHNCHKHAEC 665
+ PC + +EC
Sbjct: 892 TQ-PCPESWSEWSDWSEC 908
Score = 73.9 bits (180), Expect = 8e-13
Identities = 50/149 (33%), Positives = 61/149 (40%), Gaps = 32/149 (21%)
Query: 360 CASPSFVEGEC----CPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTS--- 412
C PS EC CP VDG WS W+ WT+CS TCG G R RSC +
Sbjct: 823 CLGPSLEYQECNILPCP-----VDGV--WSCWSPWTKCSATCGGGHYMRTRSCSNPAPAY 875
Query: 413 --NTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQ 470
+ CLG + C+ C WS WS WS C + G R R C P
Sbjct: 876 GGDICLGLHTEEALCNTQPCPE------SWSEWSDWSECEAS---GVQVRARQCILLFPM 926
Query: 471 MGGKNCKGSGRETKACQGAPCPIDGRWSP 499
G C G+ E++ PC D + P
Sbjct: 927 --GSQCSGNTTESR-----PCVFDSNFIP 948
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 129 bits (325), Expect = 1e-29
Identities = 94/316 (29%), Positives = 126/316 (39%), Gaps = 61/316 (19%)
Query: 353 ITCPPATCASPSFVEGECCPSCLHSVDG-EEGWSPWAEWTQCSVTCGSGTQQ--RGRSCD 409
+ CP C EG S + V G GW PW+ W+ CS +C + R R+
Sbjct: 3858 LECPSPDCPG---AEG----STVEPVTGLPGGWGPWSSWSPCSRSCTDPARPAWRSRTRL 3910
Query: 410 VTSNTCLGPSIQTRACSLSKCDTRIRQDG--------GWSHWSPWSSCSVTCGVGNITRI 461
+N +G +Q R C+L C G W+ W+PW CS +CGVG R+
Sbjct: 3911 CLANCTMGDPLQERPCNLPSCTELPVCPGPGCGAGNCSWTSWAPWEPCSRSCGVGQQRRL 3970
Query: 462 RLCNSPVPQMGGKNCKG---SGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERT 518
R P P GG C + +E + C CP+ G WS WSPWS C +C GG R+
Sbjct: 3971 RAYRPPGP--GGHWCPNILTAYQERRFCNLRACPVPGGWSRWSPWSWCDRSCGGGQSLRS 4028
Query: 519 RVCNSPEPQYGGKACVGDVQERQMCNKRSCPVDGC--------LSNPCFPGAQCSSFPDG 570
R C+SP + GG C G+ + ++CN C GC +N C +CS +G
Sbjct: 4029 RSCSSPPSKNGGAPCAGERHQARLCNPMPCEA-GCPAGMEVVTCANRC--PRRCSDLQEG 4085
Query: 571 ---------SWSCGSCPVGFLGNGTHCEDLDECALV-------------PDICFSTSKVP 608
C CP G L C + C D C + S
Sbjct: 4086 IVCQDDQVCQKGC-RCPKGSLEQDGGCVPIGHCDCTDAQGHSWAPGSQHQDACNNCS--- 4141
Query: 609 RCVNTQPGFHCLPCPP 624
C Q PCPP
Sbjct: 4142 -CQAGQLSCTAQPCPP 4156
Score = 127 bits (320), Expect = 5e-29
Identities = 86/278 (30%), Positives = 117/278 (42%), Gaps = 57/278 (20%)
Query: 332 TWVVDSCTTCTCKKFKTICHQITCPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWT 391
++++ +C+ C C+K ++ C P C P GWS W+ W
Sbjct: 2689 SFLLGNCSQCVCEK-----GELLCQPGGCPLPC------------------GWSAWSSWA 2725
Query: 392 QCSVTCGSGTQQRGRSCDVTSNT--------CLGPSIQTRACSLSKCDTRIRQDGGWSHW 443
C +CGSG + R RS SN C G + + C + C T + GW+ W
Sbjct: 2726 PCDRSCGSGVRARFRS---PSNPPAAWGGAPCEGDRQELQGCH-TVCGTEVF---GWTPW 2778
Query: 444 SPWSSCSVTC-----GVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRWS 498
+ WSSCS +C G G +R RLC SP G +C G + + C CP+ W
Sbjct: 2779 TSWSSCSQSCLAPGGGPGWRSRSRLCPSP----GDSSCPGDATQEEPCSPPVCPVPSIWG 2834
Query: 499 PWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVDGCLSNPC 558
W+PWS C+ C GGI+ R R C+S P G C G + + CN + C C N
Sbjct: 2835 LWAPWSTCSAPCDGGIQTRGRSCSSLAP--GDTTCPGPHSQTRDCNTQPCTAQ-CPENML 2891
Query: 559 FPGA-QCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECA 595
F A QC G CP L G E CA
Sbjct: 2892 FRSAEQCHQ------EGGPCPRLCLTQGPGIECTGFCA 2923
Score = 112 bits (279), Expect = 3e-24
Identities = 82/285 (28%), Positives = 106/285 (37%), Gaps = 53/285 (18%)
Query: 440 WSHWSPWSSCSVTCGVGNITRIRLCNS------------PVPQMGGKNCKGSGRETKACQ 487
WS W+PWS CS +CG R R C P+P C G E + C
Sbjct: 3186 WSPWTPWSQCSASCGPARCHRHRFCARSPSAVPSTVAPLPLPATPTPLCSGPEAEEEPCL 3245
Query: 488 GAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRS 547
C G W PW PWS C+ +C GG+R RTR C+ P PQ G C G + ++C
Sbjct: 3246 LQGCDRAGGWGPWGPWSHCSRSCGGGLRSRTRACDQPPPQGLGDYCEGPRAQGEVCQALP 3305
Query: 548 CPVDGCLS------NPCFPGA--QCSSFPDGSWSCGS---CPVG--FLGNGTHCEDLDEC 594
CPV C + +PC P C W C CP G NG C C
Sbjct: 3306 CPVTNCTAIEGAEYSPCGPPCPRSCDDLVHCVWRCQPGCYCPPGQVLSSNGAICVQPGHC 3365
Query: 595 ALVPDICFSTSKVPRCVNTQPG--FHC-----------LPCPPRYRGNQPVGVGLEAAKT 641
+ + D+ P +P HC LPCP G +
Sbjct: 3366 SCL-DLLTGQRHHPGARLARPDGCNHCTCLEGRLNCTDLPCPV---------PGGWCPWS 3415
Query: 642 EKQVCEPENPCKDKTHNCHKHAECIYLGHFSDPMYKCECQTGYAG 686
E +C PC+ +T + + C H P C + G AG
Sbjct: 3416 EWTMC--SQPCRGQTRSRSRACACPTPQHGGAP---CTGEAGEAG 3455
Score = 110 bits (274), Expect = 1e-23
Identities = 73/209 (34%), Positives = 95/209 (45%), Gaps = 45/209 (21%)
Query: 416 LGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKN 475
+GPS + + C G W WSPW CS TCG R R C SP+ + +N
Sbjct: 1685 VGPSPEEQGC------------GAWGPWSPWGPCSRTCGPWGQGRSRRC-SPLGLLVLQN 1731
Query: 476 CKGSGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACV- 534
C G +++AC A CP+DG WS WSPWS C+ C G + R R C+S PQ GG+ C
Sbjct: 1732 CPGPEHQSQACFTAACPVDGEWSTWSPWSVCSEPCRGTM-TRQRQCHS--PQNGGRTCAA 1788
Query: 535 --GDVQERQMCNKRSCPVDGC---------LSNPCFP--------GAQCSSFPDGSWSCG 575
G + + + CP DGC + PC P Q + PD W CG
Sbjct: 1789 LPGGLHSTR--QTKPCPQDGCPNATCSGELMFQPCAPCPLTCDDISGQVTCPPD--WPCG 1844
Query: 576 S----CPVG-FLGNGTHCEDLDECALVPD 599
S CP G LG+ C +C + D
Sbjct: 1845 SPGCWCPEGQVLGSEGWCVWPRQCPCLVD 1873
Score = 105 bits (263), Expect = 2e-22
Identities = 101/369 (27%), Positives = 137/369 (37%), Gaps = 79/369 (21%)
Query: 320 CWQDGRFFAENETWVVDSCTTCTCKKFKTICHQITCPPATCASPSFVEGECCPSCLHSVD 379
C +G + T VV C C+C ++ A C+S EGE
Sbjct: 3144 CAHEGHLYPPGST-VVRPCENCSC---------VSGLIANCSSWPCAEGE---------- 3183
Query: 380 GEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNT-----------------CLGPSIQT 422
WSPW W+QCS +CG R R C + + C GP +
Sbjct: 3184 --PTWSPWTPWSQCSASCGPARCHRHRFCARSPSAVPSTVAPLPLPATPTPLCSGPEAEE 3241
Query: 423 RACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRE 482
C L CD + GGW W PWS CS +CG G +R R C+ P PQ G C+G +
Sbjct: 3242 EPCLLQGCD----RAGGWGPWGPWSHCSRSCGGGLRSRTRACDQPPPQGLGDYCEGPRAQ 3297
Query: 483 TKACQGAPCPI-------DGRWSPWSPWSACTVTCAGGIRERTRV---CNSPEPQY---G 529
+ CQ PCP+ +SP P C +C + R C P Q
Sbjct: 3298 GEVCQALPCPVTNCTAIEGAEYSPCGP--PCPRSCDDLVHCVWRCQPGCYCPPGQVLSSN 3355
Query: 530 GKACVGDVQERQMCNKRSCPVDGCLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCE 589
G CV + C SC +D PGA+ + PDG C +C G L +C
Sbjct: 3356 GAICV----QPGHC---SC-LDLLTGQRHHPGARLAR-PDGCNHC-TCLEGRL----NCT 3401
Query: 590 DLDECALVPDIC----FSTSKVPRCVNTQPGFHCLPCPPRYRGNQPV--GVGLEAAKTEK 643
DL C + C ++ P T+ CP G P G A+ ++
Sbjct: 3402 DL-PCPVPGGWCPWSEWTMCSQPCRGQTRSRSRACACPTPQHGGAPCTGEAGEAGAQHQR 3460
Query: 644 QVCEPENPC 652
+ C C
Sbjct: 3461 EACPSYATC 3469
Score = 104 bits (259), Expect = 6e-22
Identities = 79/289 (27%), Positives = 100/289 (34%), Gaps = 46/289 (15%)
Query: 349 ICHQITCPPATCASPSFVE-GECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRS 407
+C + CP C + E C P C S D + W C G G
Sbjct: 3300 VCQALPCPVTNCTAIEGAEYSPCGPPCPRSCD-DLVHCVWRCQPGCYCPPGQVLSSNGAI 3358
Query: 408 CDVTSN-TCLGPSIQTR-----------ACSLSKC--------DTRIRQDGGWSHWSPWS 447
C + +CL R C+ C D GGW WS W+
Sbjct: 3359 CVQPGHCSCLDLLTGQRHHPGARLARPDGCNHCTCLEGRLNCTDLPCPVPGGWCPWSEWT 3418
Query: 448 SCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRET------KACQG-APCPIDGRWSPW 500
CS C +R R C P PQ GG C G E +AC A CP+DG W PW
Sbjct: 3419 MCSQPCRGQTRSRSRACACPTPQHGGAPCTGEAGEAGAQHQREACPSYATCPVDGAWGPW 3478
Query: 501 SPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVDGC------- 553
PWS C + G R+R C+ P GG+ C G+ + + C + S C
Sbjct: 3479 GPWSPCDMCL--GQSHRSRACSRPPTPEGGRPCPGNHTQSRPCQENSTQCTDCGGGQSLH 3536
Query: 554 -LSNPC-------FPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDEC 594
PC PG+ C G CP+G L C C
Sbjct: 3537 PCGQPCPRSCQDLSPGSVCQPGSVGCQPTCGCPLGQLSQDGLCVPPAHC 3585
Score = 103 bits (257), Expect = 1e-21
Identities = 71/217 (32%), Positives = 90/217 (41%), Gaps = 43/217 (19%)
Query: 443 WSPWSSCSVTCGVG-NITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRWSPWS 501
WS WSSCS +CG+G R L P+P G +C +++C CP+ G W+ W
Sbjct: 2506 WSVWSSCSRSCGLGLTFQRQELLRPPLP---GGSCPRDRFRSQSCFVQACPVAGAWAMWE 2562
Query: 502 PWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSC------------- 548
W C+V+C GG + R R C P P+ GG C G QER C + C
Sbjct: 2563 AWGPCSVSCGGGHQSRQRSCVDPPPKNGGAPCPGASQERAPCGLQPCSGGTDCELGRVYV 2622
Query: 549 PVDGC---LSNPCFPGAQCSSFPDGSWSCGS-------CPVGFLGNGTHCEDLDECALV- 597
D C L PC P C P + SC CP G L + T C L EC +
Sbjct: 2623 SADLCQKGLVPPCPP--SCLD-PKANRSCSGHCVEGCRCPPGLLLHDTRCLPLSECPCLV 2679
Query: 598 ------PDICFSTSKVPRCV------NTQPGFHCLPC 622
P + F +CV QPG LPC
Sbjct: 2680 GEELKWPGVSFLLGNCSQCVCEKGELLCQPGGCPLPC 2716
Score = 102 bits (255), Expect = 2e-21
Identities = 96/377 (25%), Positives = 121/377 (32%), Gaps = 105/377 (27%)
Query: 355 CPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTS-- 412
C P C PS W WA W+ CS C G Q RGRSC +
Sbjct: 2822 CSPPVCPVPSI------------------WGLWAPWSTCSAPCDGGIQTRGRSCSSLAPG 2863
Query: 413 -NTCLGPSIQTRACSLSKCDTRI------------RQDGG-----WSHWSPWSSCSVTCG 454
TC GP QTR C+ C + Q+GG P C+ C
Sbjct: 2864 DTTCPGPHSQTRDCNTQPCTAQCPENMLFRSAEQCHQEGGPCPRLCLTQGPGIECTGFCA 2923
Query: 455 VG----------NITRIRLCNSPVPQMGGKNCKG--------------SGRETKACQGAP 490
G N + + P G G SG+ AC
Sbjct: 2924 PGCTCPPGLFLHNASCLPRSQCPCQLHGQLYASGAMARLDSCNNCTCVSGK--MACTSER 2981
Query: 491 CPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPV 550
CP+ WSPW+ WS C+ +C GIR R R +P +GG C G E + C+ R CP
Sbjct: 2982 CPVACGWSPWTLWSLCSCSCNVGIRRRFRAGTAPPAAFGGAECQGPTMEAEFCSLRPCP- 3040
Query: 551 DGCLSNPCFPGAQCSSFPDGSWSCGSCPVG------FLGNGTHCEDLDECALVPDICFST 604
PG + G WS S P G G+ + C L P
Sbjct: 3041 --------GPGGEW-----GPWSPCSVPCGGGYRNRTRGSSRSLMEFSTCGLQP----CA 3083
Query: 605 SKVP-RCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCKDKTHNCHKHA 663
VP C + C P L A + Q C P CH +
Sbjct: 3084 GPVPGMCPRDKQWLDCAQGPASC-------AELSAPRGTNQTCHP---------GCHCPS 3127
Query: 664 ECIYLGHFSDPMYKCEC 680
+ L + P C C
Sbjct: 3128 GMLLLNNVCVPTQDCPC 3144
Score = 100 bits (249), Expect = 8e-21
Identities = 79/287 (27%), Positives = 109/287 (37%), Gaps = 58/287 (20%)
Query: 320 CWQDGRFFAENETWVVDSCTTCTCKKFKTICHQITCPPATCASPSFVEGECCPSCLHSVD 379
C Q R ++W+ C C+C IC CA P
Sbjct: 4215 CLQGTRSRTLGDSWLQGECQRCSCTPEGVICED-----TECAVP---------------- 4253
Query: 380 GEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVT-----SNTCLGPSIQTRACSLSKCDTRI 434
E W+ W+ W+ C V+CG G Q R R+C S CLGP QTR C +
Sbjct: 4254 --EAWTLWSSWSDCPVSCGGGNQVRTRACRAAAPHHRSPPCLGPDTQTRQ---QPCPGLL 4308
Query: 435 RQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGS--GRETKACQGAPCP 492
W PW CS +CG G +R C + + C + +T+ C PCP
Sbjct: 4309 EA----CSWGPWGPCSRSCGPGLASRSGSCPCLMAK-ADPTCNSTFLHLDTQGCYSGPCP 4363
Query: 493 IDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVDG 552
+ WS WS W+ C +C +++R R + G +A G R + R C +
Sbjct: 4364 EECVWSSWSSWTRC--SCRVLVQQRYR--HQGPASRGARA--GAPCTRLDGHFRPCLISN 4417
Query: 553 CLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTH-----CEDLDEC 594
C + C P P +CGS G TH C+DL C
Sbjct: 4418 CSEDSCTP-------PFEFHACGSPCAGLC--ATHLSHQLCQDLPPC 4455
Score = 100 bits (248), Expect = 1e-20
Identities = 66/181 (36%), Positives = 83/181 (45%), Gaps = 28/181 (15%)
Query: 350 CHQITCPPATCASPSFV---EGECC-PSCLHSVDGEEG---WSPWAEWTQCSVTCGSGTQ 402
C + TCP TC V + +C P + E+G W PW+ W CS TCG Q
Sbjct: 1656 CPEYTCPNGTCIGFQLVCDGQPDCGRPGQVGPSPEEQGCGAWGPWSPWGPCSRTCGPWGQ 1715
Query: 403 QRGRSCD----VTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNI 458
R R C + C GP Q++AC + C DG WS WSPWS CS C G +
Sbjct: 1716 GRSRRCSPLGLLVLQNCPGPEHQSQACFTAACPV----DGEWSTWSPWSVCSEPCR-GTM 1770
Query: 459 TRIRLCNSPVPQMGGKNCKG------SGRETKACQGAPCP---IDGRWSPWSPWSACTVT 509
TR R C+S PQ GG+ C S R+TK C CP G + P + C +T
Sbjct: 1771 TRQRQCHS--PQNGGRTCAALPGGLHSTRQTKPCPQDGCPNATCSGELM-FQPCAPCPLT 1827
Query: 510 C 510
C
Sbjct: 1828 C 1828
Score = 90.1 bits (222), Expect = 1e-17
Identities = 73/248 (29%), Positives = 99/248 (39%), Gaps = 52/248 (20%)
Query: 336 DSCTTCTCKKFKTICHQITCPPAT-CASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCS 394
D+C C+C+ + C CPP T CA WS W+ W+ CS
Sbjct: 4135 DACNNCSCQAGQLSCTAQPCPPPTHCA----------------------WSHWSAWSPCS 4172
Query: 395 VTCGS-GTQQRGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTC 453
+CG G Q R RS T +C R++ S P SC C
Sbjct: 4173 HSCGPRGQQSRFRS-------------STSGSWAPEC----REEQSQSQPCPQPSCPPLC 4215
Query: 454 GVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGG 513
G TR R Q + C + E C+ C + W+ WS WS C V+C GG
Sbjct: 4216 LQG--TRSRTLGDSWLQGECQRCSCTP-EGVICEDTECAVPEAWTLWSSWSDCPVSCGGG 4272
Query: 514 IRERTRVCNSPEPQYGGKACVG-DVQERQMCNKRSCP--VDGCLSNPCFPGAQCSSFPDG 570
+ RTR C + P + C+G D Q RQ + CP ++ C P P ++ S P
Sbjct: 4273 NQVRTRACRAAAPHHRSPPCLGPDTQTRQ----QPCPGLLEACSWGPWGPCSR-SCGPGL 4327
Query: 571 SWSCGSCP 578
+ GSCP
Sbjct: 4328 ASRSGSCP 4335
Score = 86.7 bits (213), Expect = 1e-16
Identities = 57/176 (32%), Positives = 74/176 (42%), Gaps = 30/176 (17%)
Query: 424 ACSLSKCDTRIRQDGGWSHWSPWSSCSVTC-GVGNITRIRLCNSPVPQMGGKNCKGSGRE 482
+CSL C DGG+ WSPW CS +C G+G TR R C +P + G+ C+G R+
Sbjct: 3801 SCSLDDC---FEADGGFGPWSPWGPCSRSCGGLGTRTRSRQCVLTMPTLSGQGCRGP-RQ 3856
Query: 483 TKACQGAPCP------------IDGRWSPWSPWSACTVTCAG----GIRERTRVCNSPEP 526
C CP + G W PWS WS C+ +C R RTR+C +
Sbjct: 3857 DLECPSPDCPGAEGSTVEPVTGLPGGWGPWSSWSPCSRSCTDPARPAWRSRTRLCLA--- 3913
Query: 527 QYGGKACVGDVQERQMCNKRSCPVDGCLSNPCFPGAQCSSFPDGSWS-CG-SCPVG 580
+GD + + CN SC P CS W C SC VG
Sbjct: 3914 ----NCTMGDPLQERPCNLPSCTELPVCPGPGCGAGNCSWTSWAPWEPCSRSCGVG 3965
Score = 86.3 bits (212), Expect = 2e-16
Identities = 119/465 (25%), Positives = 154/465 (33%), Gaps = 123/465 (26%)
Query: 336 DSCTTCTCKKFKTICHQITCPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSV 395
D C CTC + + C + CP V G GW PW+EWT CS
Sbjct: 3386 DGCNHCTCLEGRLNCTDLPCP---------------------VPG--GWCPWSEWTMCSQ 3422
Query: 396 TCGSGTQQRGRSCDVTSNT-----CLGPS------IQTRAC-SLSKCDTRIRQDGGWSHW 443
C T+ R R+C + C G + Q AC S + C DG W W
Sbjct: 3423 PCRGQTRSRSRACACPTPQHGGAPCTGEAGEAGAQHQREACPSYATCPV----DGAWGPW 3478
Query: 444 SPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQ---------------- 487
PWS C + G + R R C+ P GG+ C G+ +++ CQ
Sbjct: 3479 GPWSPCDMCLGQSH--RSRACSRPPTPEGGRPCPGNHTQSRPCQENSTQCTDCGGGQSLH 3536
Query: 488 --GAPCPIDGRWSPWSPWSAC---------TVTCAGGIRERTRVCNSP---EPQY-GGKA 532
G PCP SP S C T C G + +C P QY G
Sbjct: 3537 PCGQPCP--RSCQDLSPGSVCQPGSVGCQPTCGCPLGQLSQDGLCVPPAHCRCQYQPGAM 3594
Query: 533 CVGDVQERQMCNKRSC------------PVDGCLSNPCFPG-AQCSSFPD----GSWSC- 574
+ + Q R ++ S P D C C G QC PD G WS
Sbjct: 3595 GIPENQSRSAGSRFSSWESLEPGEVVTGPCDNC---TCVAGILQCQEVPDCPDPGVWSSW 3651
Query: 575 ---GSCPVGFLGNGTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHC-LPCPPRYRGNQ 630
C V G G CA P C ++ R +TQ P YR Q
Sbjct: 3652 GPWEDCSVS-CGGGEQLRS-RRCARPP--CPGPARQSRTCSTQVCREAGCPAGRLYRECQ 3707
Query: 631 P-VGVGLEAAKTEKQV------CEPENPCKDKTHN----CHKHAECIYLGHFSDPMYKCE 679
P G A +QV CE C + T C + C+ + +
Sbjct: 3708 PGEGCPFSCAHVTQQVGCFSEGCEEGCHCPEGTFQHRLACVQECPCVLTAWL---LQELG 3764
Query: 680 CQTGYAGDGLICGEDSDLDGWPNLNLVCATNATYH----CIKDNC 720
G G L G +LD L C + H C D+C
Sbjct: 3765 ATIGDPGQPL--GPGDELDSGQTLRTSCGNCSCAHGKLSCSLDDC 3807
Score = 83.2 bits (204), Expect = 1e-15
Identities = 65/193 (33%), Positives = 79/193 (40%), Gaps = 25/193 (12%)
Query: 307 LIGGPPKTRNMSACWQDGRFFAENETW----VVDSCTTC--TCKKFKTICHQITCPPA-T 359
L GG TR C QDG N T + C C TC I Q+TCPP
Sbjct: 1789 LPGGLHSTRQTKPCPQDG---CPNATCSGELMFQPCAPCPLTCDD---ISGQVTCPPDWP 1842
Query: 360 CASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPS 419
C SP G CP V G EGW W QC G+ C+
Sbjct: 1843 CGSP----GCWCPE--GQVLGSEGWCVWPR--QCPCLVDGARYWPGQRIKADCQLCICQD 1894
Query: 420 IQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNIT-RIRLCNSPVPQMGGKNCKG 478
+ R C L+ D + D GWS WSPW+ C CG +I R N+P P G+ C+G
Sbjct: 1895 GRPRRCRLNP-DCAV--DCGWSSWSPWAKCLGPCGSQSIQWSFRSSNNPRPSGRGRQCRG 1951
Query: 479 SGRETKACQGAPC 491
R+ + CQ PC
Sbjct: 1952 IHRKARRCQTEPC 1964
Score = 82.8 bits (203), Expect = 2e-15
Identities = 77/290 (26%), Positives = 100/290 (34%), Gaps = 75/290 (25%)
Query: 315 RNMSACWQDGRFFAENETWVVDSCTTCTCKKFKTICHQITCPPATCASPSFVEGECCPSC 374
R+ C G+ +A +DSC CTC K C CP A
Sbjct: 2942 RSQCPCQLHGQLYASGAMARLDSCNNCTCVSGKMACTSERCPVAC--------------- 2986
Query: 375 LHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRS-----CDVTSNTCLGPSIQTRACSLSK 429
GWSPW W+ CS +C G ++R R+ C GP+++ CSL
Sbjct: 2987 --------GWSPWTLWSLCSCSCNVGIRRRFRAGTAPPAAFGGAECQGPTMEAEFCSLRP 3038
Query: 430 CDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGR---ETKAC 486
C G W PWS CSV CG G R R GS R E C
Sbjct: 3039 C------PGPGGEWGPWSPCSVPCGGGYRNRTR---------------GSSRSLMEFSTC 3077
Query: 487 QGAPC--PIDGRWSPWSPWSACT---VTCA--GGIRERTRVCNSPEPQYGGKACVGDV-- 537
PC P+ G W C +CA R + C+ G + +V
Sbjct: 3078 GLQPCAGPVPGMCPRDKQWLDCAQGPASCAELSAPRGTNQTCHPGCHCPSGMLLLNNVCV 3137
Query: 538 --------QERQMCNKRSCPVDGCLSNPCFPG--AQCSSFP----DGSWS 573
E + S V C + C G A CSS+P + +WS
Sbjct: 3138 PTQDCPCAHEGHLYPPGSTVVRPCENCSCVSGLIANCSSWPCAEGEPTWS 3187
Score = 72.4 bits (176), Expect = 2e-12
Identities = 139/565 (24%), Positives = 190/565 (33%), Gaps = 162/565 (28%)
Query: 354 TCPPATCASPSFVE------GECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRS 407
T P C +P + G C SC WS W W+ C V C G + R R
Sbjct: 4590 TGAPHLCTAPLSQQRLCPDPGACPDSCQ--------WSLWGPWSPCQVPCSGGFRLRWRE 4641
Query: 408 CD-VTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSH-------------WS--------- 444
+ + C P Q +C+ C QD ++ W
Sbjct: 4642 AEALCGGGCREPWAQ-ESCNGGPCPECEAQDTVFTLDCANQCPHSCADLWDRVQCLQGPC 4700
Query: 445 ------------------PWSSCSVTCGVGNITRI-RLCNSPVPQMGGKNCKGSGRETKA 485
P SSC CG+ + L + Q+ +NC E+
Sbjct: 4701 RPGCRCPPGQLVQDGRCVPISSCR--CGLPSANASWELAPAQAVQLDCQNCT-CVNESLV 4757
Query: 486 CQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKAC-VGDVQERQMCN 544
C CP+ G PWS WS+C+ C GG ER R C E G C D ++RQ CN
Sbjct: 4758 CPHQECPVLG---PWSAWSSCSAPCGGGTMERHRTC---EGGPGVAPCQAQDTEQRQECN 4811
Query: 545 KRSCP-------VDGCLSN-PCF-----PGAQCSSFPDGSWSCGSCPVG-FLGNGTHCED 590
+ CP + C ++ PC PGA C P CG CP G L NGT C
Sbjct: 4812 LQPCPECPPGQVLSACATSCPCLCWHLQPGAICVQEPCQP-GCG-CPGGQLLHNGT-CVP 4868
Query: 591 LDECAL-------------------VPDICFSTSKVPRCVNTQPGFHC--LPC--PPRYR 627
C +P T RCV F C + C PP
Sbjct: 4869 PTACPCTQHSLPWGLTLTLEEQAQELPPGTVLTRNCTRCVCHGGAFSCSLVDCQVPPGET 4928
Query: 628 GNQ--PVGVGL--------EAAKTEKQ---------VCEPENPCKDKTHNC--HKHAECI 666
Q P +GL A KT+ VC+P + + + C H EC
Sbjct: 4929 WQQVAPGELGLCEQTCLEMNATKTQSNCSSARASGCVCQPGH-FRSQAGPCVPEDHCECW 4987
Query: 667 YLG--HFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNLNLVCATNATYHCIKDNCPHLP 724
+LG H ++ C++ +C L G P VC T HC C
Sbjct: 4988 HLGRPHLPGSEWQEACES------CLC-----LSGRP----VC----TQHCSPLTCA--- 5025
Query: 725 NSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLL-----FNPRQADYDKDEVGDRCDNC 779
G+E + G +C + ++ +CQLL F D+ EV C
Sbjct: 5026 -QGEEMVLEPG---SCCPSCRREAPEEQSPSCQLLTELRNFTKGTCYLDQVEVSYCSGYC 5081
Query: 780 PYVHNPAQIDTDNNGEGDACSVDID 804
P + + + D CS +D
Sbjct: 5082 PSSTHVMPEEPYLQSQCDCCSYRLD 5106
Score = 65.9 bits (159), Expect = 2e-10
Identities = 81/302 (26%), Positives = 105/302 (34%), Gaps = 85/302 (28%)
Query: 360 CASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSN---TC- 415
C P + + C + VDGE WS W+ W+ CS C GT R R C N TC
Sbjct: 1732 CPGPEH-QSQACFTAACPVDGE--WSTWSPWSVCSEPC-RGTMTRQRQCHSPQNGGRTCA 1787
Query: 416 -----LGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCG--VGNITRIR--LCNS 466
L + QT+ C C G + P + C +TC G +T C S
Sbjct: 1788 ALPGGLHSTRQTKPCPQDGCPNATCS--GELMFQPCAPCPLTCDDISGQVTCPPDWPCGS 1845
Query: 467 PVPQMGGKNCKGS---------------------GRETKA------CQ-GAP-------- 490
P GS G+ KA CQ G P
Sbjct: 1846 PGCWCPEGQVLGSEGWCVWPRQCPCLVDGARYWPGQRIKADCQLCICQDGRPRRCRLNPD 1905
Query: 491 CPIDGRWSPWSPWSACTVTCAG-GIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCP 549
C +D WS WSPW+ C C I+ R N+P P G+ C G ++ + C C
Sbjct: 1906 CAVDCGWSSWSPWAKCLGPCGSQSIQWSFRSSNNPRPSGRGRQCRGIHRKARRCQTEPC- 1964
Query: 550 VDGC-------------LSNPCFP-------GAQCSSFPDGSWSCGSCPVGFL---GNGT 586
+GC PC A CS + GSCP G++ G G
Sbjct: 1965 -EGCEHQGQVHRVGERWHGGPCRVCQCLHNLTAHCSPY----CPLGSCPQGWVLVEGTGE 2019
Query: 587 HC 588
C
Sbjct: 2020 SC 2021
Score = 55.8 bits (133), Expect = 2e-07
Identities = 44/160 (27%), Positives = 58/160 (36%), Gaps = 28/160 (17%)
Query: 334 VVDSCTTCTCKKFKTICHQITCPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQC 393
V C CTC C ++ C P WS W W C
Sbjct: 3620 VTGPCDNCTCVAGILQCQEVP----DCPDPGV------------------WSSWGPWEDC 3657
Query: 394 SVTCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGG-WSHWSPWSSCSVT 452
SV+CG G Q R R C C GP+ Q+R CS C G + P C +
Sbjct: 3658 SVSCGGGEQLRSRRC--ARPPCPGPARQSRTCSTQVCREAGCPAGRLYRECQPGEGCPFS 3715
Query: 453 CGVGNITRIRLCNSPVPQMGGKNCKGSGRETKAC-QGAPC 491
C ++T+ C S + G +G+ + AC Q PC
Sbjct: 3716 C--AHVTQQVGCFSEGCEEGCHCPEGTFQHRLACVQECPC 3753
Score = 53.1 bits (126), Expect = 1e-06
Identities = 65/259 (25%), Positives = 84/259 (32%), Gaps = 65/259 (25%)
Query: 341 CTCKKFKTICHQITCPPATCASPSFVEGECCPSCLHSVD-GEEGWSPWAEWTQCSVTCGS 399
C C +T P E EC LH G +G P +EW++ S CG
Sbjct: 4478 CNCWHTSAAGAGMTLAPGDRLQLGCKECECRRGELHCTSQGCQGLLPLSEWSEWS-PCGP 4536
Query: 400 GTQQRGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNIT 459
CL PS A + + +R G S
Sbjct: 4537 ---------------CLPPSALAPASRTALEEHWLRDPTGLS------PTLAPLLASEQH 4575
Query: 460 RIRLCNSPV---PQMGGKN-CKGSGRETKACQG-APCPIDGRWSPWSPWSACTVTCAGGI 514
R RLC P P G + C + + C CP +WS W PWS C V C+GG
Sbjct: 4576 RHRLCLDPATGRPWTGAPHLCTAPLSQQRLCPDPGACPDSCQWSLWGPWSPCQVPCSGGF 4635
Query: 515 RERTRVCNSPEPQYGGKACVGDVQE---RQMCNKRSCP----------VD---------- 551
R R R + C G +E ++ CN CP +D
Sbjct: 4636 RLRWREAEA--------LCGGGCREPWAQESCNGGPCPECEAQDTVFTLDCANQCPHSCA 4687
Query: 552 ------GCLSNPCFPGAQC 564
CL PC PG +C
Sbjct: 4688 DLWDRVQCLQGPCRPGCRC 4706
Score = 45.4 bits (106), Expect = 3e-04
Identities = 28/88 (31%), Positives = 38/88 (43%), Gaps = 24/88 (27%)
Query: 352 QITCPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVT 411
Q+ C TC + S V CP V G PW+ W+ CS CG GT +R R+C+
Sbjct: 4743 QLDCQNCTCVNESLV----CPHQECPVLG-----PWSAWSSCSAPCGGGTMERHRTCEG- 4792
Query: 412 SNTCLGPSI---------QTRACSLSKC 430
GP + Q + C+L C
Sbjct: 4793 -----GPGVAPCQAQDTEQRQECNLQPC 4815
>gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]
Length = 1151
Score = 124 bits (311), Expect = 5e-28
Identities = 82/283 (28%), Positives = 108/283 (38%), Gaps = 90/283 (31%)
Query: 384 WSPWAEWTQCSVTCGSGTQQR------GRSC----------------------------- 408
W+ W W++CS CG G Q R G SC
Sbjct: 725 WASWGSWSKCSSNCGGGMQSRRRACENGNSCLGCGVEFKTCNPEGCPEVRRNTPWTPWLP 784
Query: 409 -DVTSN----------TCLGP------------SIQTRACSLS---KCDTRIRQD----- 437
+VT TC P +TR C CDT +
Sbjct: 785 VNVTQGGARQEQRFRFTCRAPLADPHGLQFGRRRTETRTCPADGSGSCDTDALVEVLLRS 844
Query: 438 ---------GGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQG 488
GGW+ W PWSSCS C +G R R C +P P+ GG C G E + C
Sbjct: 845 GSTSPHTVSGGWAAWGPWSSCSRDCELGFRVRKRTCTNPEPRNGGLPCVGDAAEYQDCNP 904
Query: 489 APCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSC 548
CP+ G WS W+ WS C+ +C GG +RTR C SP P G C+G E +C ++C
Sbjct: 905 QACPVRGAWSCWTSWSPCSASCGGGHYQRTRSCTSPAPSPGEDICLGLHTEEALCATQAC 964
Query: 549 PVDGCLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDL 591
P +P ++C+ DG+ S HCE+L
Sbjct: 965 PEGW---SPWSEWSKCTD--DGAQS----------RSRHCEEL 992
Score = 113 bits (282), Expect = 1e-24
Identities = 71/206 (34%), Positives = 103/206 (50%), Gaps = 31/206 (15%)
Query: 397 CG-SGTQQRGRSCDVTSNTCLGPSIQTRACSLSKCDTR-IRQDGGWSHWSPWSSCSVTCG 454
CG G QQR + + +SN L +++ C R + +DGG+ WSPW C G
Sbjct: 573 CGWDGKQQRCSTLEDSSNMSLWTQ------NITACPVRNVTRDGGFGPWSPWQPCEHLDG 626
Query: 455 VGN---ITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRWSPWSPWSACTVTCA 511
+ + R R C+SP P+ GG +C G A A C +G W+PWS W+ C+ +C
Sbjct: 627 DNSGSCLCRARSCDSPRPRCGGLDCLGP-----AIHIANCSRNGAWTPWSSWALCSTSCG 681
Query: 512 GGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRS-CPVDGCLSNPCFPGAQCSSFPDG 570
G + R R C++P P++GG+ CVG +E + CN+ + CPV P F + G
Sbjct: 682 IGFQVRQRSCSNPAPRHGGRICVGKSREERFCNENTPCPV------PIFWASW------G 729
Query: 571 SWS-CGS-CPVGFLGNGTHCEDLDEC 594
SWS C S C G CE+ + C
Sbjct: 730 SWSKCSSNCGGGMQSRRRACENGNSC 755
Score = 110 bits (274), Expect = 1e-23
Identities = 68/210 (32%), Positives = 90/210 (42%), Gaps = 29/210 (13%)
Query: 354 TCPP---ATCASPSFVE-----GECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRG 405
TCP +C + + VE G P H+V G GW+ W W+ CS C G + R
Sbjct: 823 TCPADGSGSCDTDALVEVLLRSGSTSP---HTVSG--GWAAWGPWSSCSRDCELGFRVRK 877
Query: 406 RSCDVTSNT-----CLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITR 460
R+C C+G + + + C+ C R G WS W+ WS CS +CG G+ R
Sbjct: 878 RTCTNPEPRNGGLPCVGDAAEYQDCNPQACPVR----GAWSCWTSWSPCSASCGGGHYQR 933
Query: 461 IRLCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRV 520
R C SP P G C G E C CP WSPWS + G + R+R
Sbjct: 934 TRSCTSPAPSPGEDICLGLHTEEALCATQACP-----EGWSPWSEWSKCTDDGAQSRSRH 988
Query: 521 CNSPEPQYGGKACVGDVQERQMCNKRSCPV 550
C P G AC G+ + + C PV
Sbjct: 989 CEELLP--GSSACAGNSSQSRPCPYSEIPV 1016
Score = 107 bits (267), Expect = 7e-23
Identities = 101/349 (28%), Positives = 139/349 (39%), Gaps = 69/349 (19%)
Query: 299 NDNQFLWELIGGPPKTRNMSAC-----WQDGRF-----FAENETWVVDSCTTCTCKKFKT 348
+ N LW T+N++AC +DG F + E D+ +C C+
Sbjct: 588 SSNMSLW--------TQNITACPVRNVTRDGGFGPWSPWQPCEHLDGDNSGSCLCRARSC 639
Query: 349 ICHQITCPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSC 408
+ C C P+ C S +G W+PW+ W CS +CG G Q R RSC
Sbjct: 640 DSPRPRCGGLDCLGPAIHIANC------SRNG--AWTPWSSWALCSTSCGIGFQVRQRSC 691
Query: 409 DVTS-----NTCLGPSIQTRACS-LSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIR 462
+ C+G S + R C+ + C I W+ W WS CS CG G +R R
Sbjct: 692 SNPAPRHGGRICVGKSREERFCNENTPCPVPI----FWASWGSWSKCSSNCGGGMQSRRR 747
Query: 463 LCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTR--- 519
C + G +C G G E K C CP R +PW+PW VT GG R+ R
Sbjct: 748 ACEN------GNSCLGCGVEFKTCNPEGCPEVRRNTPWTPWLPVNVT-QGGARQEQRFRF 800
Query: 520 VCNSP--EP---QYGGKACVGDVQERQMCNKRSCPVDGCLSNPCFPGAQCS-SFPDGSWS 573
C +P +P Q+G R+ R+CP DG S C A GS S
Sbjct: 801 TCRAPLADPHGLQFG----------RRRTETRTCPADG--SGSCDTDALVEVLLRSGSTS 848
Query: 574 CGSCPVGFLGNGTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHCLPC 622
+ G+ G +C ++ F K C N +P LPC
Sbjct: 849 PHTVSGGWAAWGPWSSCSRDC----ELGFRVRK-RTCTNPEPRNGGLPC 892
Score = 52.8 bits (125), Expect = 2e-06
Identities = 32/96 (33%), Positives = 45/96 (46%), Gaps = 21/96 (21%)
Query: 337 SCTTCTCKKFKTICHQITCPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVT 396
SCT+ + IC + A CA+ + CP EGWSPW+EW++C+
Sbjct: 936 SCTSPAPSPGEDICLGLHTEEALCAT------QACP---------EGWSPWSEWSKCT-- 978
Query: 397 CGSGTQQRGRSCDVT---SNTCLGPSIQTRACSLSK 429
G Q R R C+ S+ C G S Q+R C S+
Sbjct: 979 -DDGAQSRSRHCEELLPGSSACAGNSSQSRPCPYSE 1013
>gi|32261318 unc-5 homolog B [Homo sapiens]
Length = 945
Score = 110 bits (276), Expect = 6e-24
Identities = 54/146 (36%), Positives = 76/146 (52%), Gaps = 5/146 (3%)
Query: 403 QRGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIR 462
++ R D + TC+ +I + S + + +GGWS W+ WS CS CG G R R
Sbjct: 213 RQARLSDTANYTCVAKNIVAKRRSTT-ATVIVYVNGGWSSWAEWSPCSNRCGRGWQKRTR 271
Query: 463 LCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCN 522
C +P P GG C+G + AC CP+DG W+ WS WSAC+ CA R+R C
Sbjct: 272 TCTNPAPLNGGAFCEGQAFQKTACTTI-CPVDGAWTEWSKWSACSTECA---HWRSRECM 327
Query: 523 SPEPQYGGKACVGDVQERQMCNKRSC 548
+P PQ GG+ C G + + + C C
Sbjct: 328 APPPQNGGRDCSGTLLDSKNCTDGLC 353
Score = 91.7 bits (226), Expect = 4e-18
Identities = 47/133 (35%), Positives = 65/133 (48%), Gaps = 3/133 (2%)
Query: 359 TCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGP 418
TC + + V + V GWS WAEW+ CS CG G Q+R R+C + G
Sbjct: 224 TCVAKNIVAKRRSTTATVIVYVNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGA 283
Query: 419 SIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKG 478
+ +A + C T DG W+ WS WS+CS C R R C +P PQ GG++C G
Sbjct: 284 FCEGQAFQKTACTTICPVDGAWTEWSKWSACSTECA---HWRSRECMAPPPQNGGRDCSG 340
Query: 479 SGRETKACQGAPC 491
+ ++K C C
Sbjct: 341 TLLDSKNCTDGLC 353
Score = 60.8 bits (146), Expect = 7e-09
Identities = 25/60 (41%), Positives = 34/60 (56%), Gaps = 1/60 (1%)
Query: 493 IDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVDG 552
++G WS W+ WS C+ C G ++RTR C +P P GG C G ++ C CPVDG
Sbjct: 245 VNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACT-TICPVDG 303
>gi|209977117 unc-5 homolog D [Homo sapiens]
Length = 953
Score = 110 bits (276), Expect = 6e-24
Identities = 56/149 (37%), Positives = 76/149 (51%), Gaps = 5/149 (3%)
Query: 403 QRGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIR 462
++ R D + TC+ +I + SLS + +GGWS W+ WS+C+V CG G R R
Sbjct: 219 RQARLSDSGNYTCMAANIVAKRRSLS-ATVVVYVNGGWSSWTEWSACNVRCGRGWQKRSR 277
Query: 463 LCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCN 522
C +P P GG C+G + C CP+DG W WS WS C+ C R R C
Sbjct: 278 TCTNPAPLNGGAFCEGMSVQKITCTSL-CPVDGSWEVWSEWSVCSPECE---HLRIRECT 333
Query: 523 SPEPQYGGKACVGDVQERQMCNKRSCPVD 551
+P P+ GGK C G QE + C C +D
Sbjct: 334 APPPRNGGKFCEGLSQESENCTDGLCILD 362
Score = 91.7 bits (226), Expect = 4e-18
Identities = 52/141 (36%), Positives = 68/141 (48%), Gaps = 13/141 (9%)
Query: 359 TCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNT---- 414
TC + + V S V GWS W EW+ C+V CG G Q+R R+C +
Sbjct: 230 TCMAANIVAKRRSLSATVVVYVNGGWSSWTEWSACNVRCGRGWQKRSRTCTNPAPLNGGA 289
Query: 415 -CLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGG 473
C G S+Q C+ S C DG W WS WS CS C RIR C +P P+ GG
Sbjct: 290 FCEGMSVQKITCT-SLCPV----DGSWEVWSEWSVCSPEC---EHLRIRECTAPPPRNGG 341
Query: 474 KNCKGSGRETKACQGAPCPID 494
K C+G +E++ C C +D
Sbjct: 342 KFCEGLSQESENCTDGLCILD 362
>gi|16933525 unc5C [Homo sapiens]
Length = 931
Score = 109 bits (273), Expect = 1e-23
Identities = 54/146 (36%), Positives = 74/146 (50%), Gaps = 5/146 (3%)
Query: 403 QRGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIR 462
++ R D + TC+ +I + S + + +GGWS W+ WS C+ CG G R R
Sbjct: 227 KQARLSDTANYTCVAKNIVAKRKSTT-ATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTR 285
Query: 463 LCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCN 522
C +P P GG C+G + AC CP+DGRW+PWS WS C C R R C
Sbjct: 286 TCTNPAPLNGGAFCEGQSVQKIACT-TLCPVDGRWTPWSKWSTCGTECT---HWRRRECT 341
Query: 523 SPEPQYGGKACVGDVQERQMCNKRSC 548
+P P+ GGK C G V + + C C
Sbjct: 342 APAPKNGGKDCDGLVLQSKNCTDGLC 367
Score = 84.7 bits (208), Expect = 5e-16
Identities = 47/138 (34%), Positives = 64/138 (46%), Gaps = 13/138 (9%)
Query: 359 TCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNT---- 414
TC + + V + V GWS W EW+ C+ CG G Q+R R+C +
Sbjct: 238 TCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGA 297
Query: 415 -CLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGG 473
C G S+Q AC+ T DG W+ WS WS+C C R R C +P P+ GG
Sbjct: 298 FCEGQSVQKIACT-----TLCPVDGRWTPWSKWSTCGTEC---THWRRRECTAPAPKNGG 349
Query: 474 KNCKGSGRETKACQGAPC 491
K+C G ++K C C
Sbjct: 350 KDCDGLVLQSKNCTDGLC 367
Score = 60.8 bits (146), Expect = 7e-09
Identities = 25/60 (41%), Positives = 33/60 (55%), Gaps = 1/60 (1%)
Query: 493 IDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVDG 552
++G WS W+ WS C C G ++RTR C +P P GG C G ++ C CPVDG
Sbjct: 259 VNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACT-TLCPVDG 317
>gi|110347423 spondin 1, extracellular matrix protein [Homo sapiens]
Length = 807
Score = 109 bits (273), Expect = 1e-23
Identities = 69/196 (35%), Positives = 92/196 (46%), Gaps = 25/196 (12%)
Query: 366 VEGECCPS-CLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVT---SNTCLGPSIQ 421
V EC PS CL + W EW +CS TCG G ++R R + + C + Q
Sbjct: 550 VNEECSPSSCL--------MTEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQ 601
Query: 422 TRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGR 481
C + +C T S WS WS CSVTCG G TR R+ S + ++G +C
Sbjct: 602 AEKCMMPECHTIPCL---LSPWSEWSDCSVTCGKGMRTRQRMLKS-LAELG--DCNEDLE 655
Query: 482 ETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQ 541
+ + C CPID + WS WS C +C G RTR+ EPQ+GG C VQ
Sbjct: 656 QVEKCMLPECPIDCELTEWSQWSECNKSCGKGHVIRTRMIQM-EPQFGGAPCPETVQ--- 711
Query: 542 MCNKRSCPVDGCLSNP 557
++ C + CL NP
Sbjct: 712 ---RKKCRIRKCLRNP 724
Score = 91.3 bits (225), Expect = 5e-18
Identities = 63/229 (27%), Positives = 95/229 (41%), Gaps = 27/229 (11%)
Query: 337 SCTTCTCKKFKTICHQ---------ITCPPATCASPSFVEGECCPSCLHSVDGEEGWSPW 387
+C++ TC K K + + + CP P P C S W
Sbjct: 453 ACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMG-----PGCSDEDGSTCTMSEW 507
Query: 388 AEWTQCSVTCGSGTQQRGR---SCDVTSNTCLGPSIQTRACSLSK-CDTRIRQDGGWSHW 443
W+ CS++CG G + R R + C P+ +T C++++ C + W
Sbjct: 508 ITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSP---SSCLMTEW 564
Query: 444 SPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPC-PIDGRWSPWSP 502
W CS TCG+G R R+ + G CK + + C C I SPWS
Sbjct: 565 GEWDECSATCGMGMKKRHRMIK--MNPADGSMCKAETSQAEKCMMPECHTIPCLLSPWSE 622
Query: 503 WSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVD 551
WS C+VTC G+R R R+ S + G C D+++ + C CP+D
Sbjct: 623 WSDCSVTCGKGMRTRQRMLKS-LAELGD--CNEDLEQVEKCMLPECPID 668
Score = 85.5 bits (210), Expect = 3e-16
Identities = 59/196 (30%), Positives = 76/196 (38%), Gaps = 38/196 (19%)
Query: 385 SPWAEWTQCSVTCGSG--TQQRGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSH 442
SPW+EW+ CSVTCG G T+QR C Q C L +C D +
Sbjct: 618 SPWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEKCMLPECPI----DCELTE 673
Query: 443 WSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKA----CQGAPCPIDGRWS 498
WS WS C+ +CG G++ R R+ PQ GG C + + K C P RW
Sbjct: 674 WSQWSECNKSCGKGHVIRTRMIQME-PQFGGAPCPETVQRKKCRIRKCLRNPSIQKLRWR 732
Query: 499 --------------------------PWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKA 532
PW+ WS CT C GGI+ER +
Sbjct: 733 EARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQFTS 792
Query: 533 CVGDVQERQMCNKRSC 548
C D +E + CN C
Sbjct: 793 C-KDKKEIRACNVHPC 807
Score = 69.7 bits (169), Expect = 2e-11
Identities = 50/187 (26%), Positives = 74/187 (39%), Gaps = 9/187 (4%)
Query: 384 WSPWAEWTQCSV-TCGSGTQQRGRSCDVTSNTCLG-PSIQT-RACSLSKCDTRIRQDGGW 440
+S W+ W+ CS TC G + R R + + P Q + C C
Sbjct: 445 YSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGSTCTM 504
Query: 441 SHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQ-GAPC-PIDGRWS 498
S W WS CS++CG+G +R R P+ G C ET+ C C P +
Sbjct: 505 SEWITWSPCSISCGMGMRSRERYVKQ-FPE-DGSVCTLPTEETEKCTVNEECSPSSCLMT 562
Query: 499 PWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVDGCLSNPC 558
W W C+ TC G+++R R+ G C + + + C C CL +P
Sbjct: 563 EWGEWDECSATCGMGMKKRHRMIKMNPAD--GSMCKAETSQAEKCMMPECHTIPCLLSPW 620
Query: 559 FPGAQCS 565
+ CS
Sbjct: 621 SEWSDCS 627
Score = 56.6 bits (135), Expect = 1e-07
Identities = 42/137 (30%), Positives = 59/137 (43%), Gaps = 19/137 (13%)
Query: 440 WSHWSPWSSC-SVTCGVGNITRIRLCNS------PVPQ-MGGKNCKGSGRETKACQGAPC 491
+S+WSPWS+C S TC G R R+ + P P + C G G + G+ C
Sbjct: 445 YSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDE--DGSTC 502
Query: 492 PIDGRWSPWSPWSACTVTCAGGIRERTR-VCNSPEPQYGGKACVGDVQERQMCN-KRSCP 549
+ S W WS C+++C G+R R R V PE G C +E + C C
Sbjct: 503 TM----SEWITWSPCSISCGMGMRSRERYVKQFPE---DGSVCTLPTEETEKCTVNEECS 555
Query: 550 VDGCLSNPCFPGAQCSS 566
CL +CS+
Sbjct: 556 PSSCLMTEWGEWDECSA 572
>gi|126091152 cubilin [Homo sapiens]
Length = 3623
Score = 85.5 bits (210), Expect = 3e-16
Identities = 62/184 (33%), Positives = 81/184 (44%), Gaps = 27/184 (14%)
Query: 510 CAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVD----GCLSNPCFPGAQCS 565
C GI E + EP+Y +CV D N +C +D PC QC
Sbjct: 225 CVHGICEDLMREQAGEPKY---SCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCF 281
Query: 566 SFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHCLPCPPR 625
+ GS+ CG+CP G+ GNG CED++EC + C S + CVNT HC CPP
Sbjct: 282 N-TQGSFYCGACPTGWQGNGYICEDINECEINNGGC-SVAPPVECVNTPGSSHCQACPPG 339
Query: 626 YRGNQPVGVGLEAAKTEKQVCEPENPCKDKTHNCHKHAEC-IYLGHFSDPMYKCECQTGY 684
Y+G + +VC + C CH A C LG S P+ C C GY
Sbjct: 340 YQG-------------DGRVCTLTDICSVSNGGCHPDASCSSTLG--SLPL--CTCLPGY 382
Query: 685 AGDG 688
G+G
Sbjct: 383 TGNG 386
Score = 51.6 bits (122), Expect = 4e-06
Identities = 58/209 (27%), Positives = 75/209 (35%), Gaps = 64/209 (30%)
Query: 526 PQYGGKACVGDVQERQMCNKR--SCPVDGCLSNP-------CFP---GAQCSSFPDG--- 570
PQ+ G C DV E ++ + SC G N C P G QC+S D
Sbjct: 160 PQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEG 219
Query: 571 ----------------------SWSCGSCPVG--FLGNGTHCE-DLDECALVPDICFSTS 605
+SC C G F N C D DEC+ P C S
Sbjct: 220 GSVARCVHGICEDLMREQAGEPKYSC-VCDAGWMFSPNSPACTLDRDECSFQPGPC---S 275
Query: 606 KVPRCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCKDKTHNCH--KHA 663
+ +C NTQ F+C CP ++GN +CE N C+ C
Sbjct: 276 TLVQCFNTQGSFYCGACPTGWQGNG-------------YICEDINECEINNGGCSVAPPV 322
Query: 664 ECIYLGHFSDPMYKCE-CQTGYAGDGLIC 691
EC+ S C+ C GY GDG +C
Sbjct: 323 ECVNTPGSSH----CQACPPGYQGDGRVC 347
Score = 42.7 bits (99), Expect = 0.002
Identities = 55/229 (24%), Positives = 76/229 (33%), Gaps = 52/229 (22%)
Query: 553 CLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCE-DLDECALVPDICFSTSKVPRCV 611
C SNPC G C + D S+ C CP + G C D++EC + S CV
Sbjct: 136 CSSNPCQNGGTCLNLHD-SFFC-ICPPQW--KGPLCSADVNECEIYSGTPLSCQNGGTCV 191
Query: 612 NTQPGFHCLPCPPRYRGNQPVG-----VGLEAAKTEKQVCE------------------- 647
NT + C CPP G Q G A+ +CE
Sbjct: 192 NTMGSYSC-HCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAG 250
Query: 648 ----PENP--------CKDKTHNCHKHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDS 695
P +P C + C +C + Y C TG+ G+G IC
Sbjct: 251 WMFSPNSPACTLDRDECSFQPGPCSTLVQCF---NTQGSFYCGACPTGWQGNGYIC---E 304
Query: 696 DLDGWPNLNLVCATNATYHCI----KDNCPHLPNSGQEDFDKDGIGDAC 740
D++ N C+ C+ +C P Q D + D C
Sbjct: 305 DINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDIC 353
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1
motif, 16 preproprotein [Homo sapiens]
Length = 1224
Score = 83.6 bits (205), Expect = 1e-15
Identities = 37/90 (41%), Positives = 52/90 (57%), Gaps = 5/90 (5%)
Query: 476 CKGSGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVG 535
C+G G+ K P P G WS WS WS C+ TC GG+ R+R+C +P+P +GGK C G
Sbjct: 569 CRG-GQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEG 627
Query: 536 DVQERQMCNKRSCPVDGCLSNPCFPGAQCS 565
+ ++CN + CP D + F AQC+
Sbjct: 628 STRTLKLCNSQKCPRD----SVDFRAAQCA 653
Score = 74.3 bits (181), Expect = 6e-13
Identities = 67/235 (28%), Positives = 94/235 (40%), Gaps = 58/235 (24%)
Query: 356 PPATCASPSFVEGECCPSCLHSVDGEEGWS--PWAEWTQCSVTCGSGTQQRGRSCDVTSN 413
P + C P+ + C +S WS PWAE CS TCG G ++R +C T+
Sbjct: 966 PASLCPQPAPSSRQAC----NSQSCPPAWSAGPWAE---CSHTCGKGWRKRAVACKSTNP 1018
Query: 414 TC----LGPSIQT--------RACSLSKCDTRIRQDGGWSHW--SPWSSCSVTCGVGNIT 459
+ L ++ T AC L +C + W S WS CSVTC G
Sbjct: 1019 SARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQ-----WLVSAWSQCSVTCERGTQK 1073
Query: 460 RIRLC-----NSPVPQMGGKNC----KGSGRETKACQGAPCPID----------GRWSPW 500
R C + ++ K C K S +AC PCP G W
Sbjct: 1074 RFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFA- 1132
Query: 501 SPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQ-----MCNKRSCPV 550
SPWS CT +C GG++ R+ C + GG+ G + ++ CN CP+
Sbjct: 1133 SPWSQCTASCGGGVQTRSVQCLA-----GGRPASGCLLHQKPSASLACNTHFCPI 1182
Score = 69.7 bits (169), Expect = 2e-11
Identities = 31/57 (54%), Positives = 33/57 (57%)
Query: 438 GGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCPID 494
G WS WS WS CS TCG G R RLC +P P GGK C+GS R K C CP D
Sbjct: 587 GHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRD 643
Score = 61.6 bits (148), Expect = 4e-09
Identities = 61/213 (28%), Positives = 83/213 (38%), Gaps = 37/213 (17%)
Query: 384 WSPWAEWTQCSVTCGSGTQQRGRSC---------DVTSNTCLGPSIQTR-ACSLSKCDTR 433
WS W+ CS TCG G Q R C V ++ C P+ +R AC+ C
Sbjct: 931 WSV-GNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQSCPP- 988
Query: 434 IRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGK-------NCKGSGRETKAC 486
WS PW+ CS TCG G R C S P + + R +AC
Sbjct: 989 -----AWSA-GPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEAC 1042
Query: 487 QGAPC--PIDGRWSPWSPWSACTVTCAGGIRERTRVC-----NSPEPQYGGKACVGDVQE 539
C P +W S WS C+VTC G ++R C + + K C + +
Sbjct: 1043 LLQRCHKPKKLQWLV-SAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKC-SHLPK 1100
Query: 540 RQMCNKRSCPVDGCLSNPCFPGAQCSSFPDGSW 572
+ +R+C C +P F A S GSW
Sbjct: 1101 PSLELERACAPLPCPRHPPFAAAGPSR---GSW 1130
Score = 56.2 bits (134), Expect = 2e-07
Identities = 47/152 (30%), Positives = 60/152 (39%), Gaps = 28/152 (18%)
Query: 391 TQCSVTCGSGTQQRGRSC------DVTSNTC---LGPSIQTRACSLSKCDTRIRQDGGWS 441
++CSV+CG G C V + C P C +S C WS
Sbjct: 879 SECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPP------SWS 932
Query: 442 HWSPWSSCSVTCGVGNITRIRLC-------NSPVPQMGGKNCKGSGRETKACQGAPCPID 494
+ WS+CS TCG G +R C + PVP S R+ AC CP
Sbjct: 933 VGN-WSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQ--ACNSQSCP-- 987
Query: 495 GRWSPWSPWSACTVTCAGGIRERTRVCNSPEP 526
WS PW+ C+ TC G R+R C S P
Sbjct: 988 PAWSA-GPWAECSHTCGKGWRKRAVACKSTNP 1018
Score = 52.4 bits (124), Expect = 3e-06
Identities = 49/174 (28%), Positives = 65/174 (37%), Gaps = 26/174 (14%)
Query: 447 SSCSVTCGVGNITRIRLCNSPVP-QMGGKNCKGSGRETKACQGAPCPIDGRWSPWS--PW 503
S CSV+CG G +T C + Q+ C R PC + WS W
Sbjct: 879 SECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGL--VPCKVSACPPSWSVGNW 936
Query: 504 SACTVTCAGGIRER-----TRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVDGCLSNPC 558
SAC+ TC GG + R RV EP RQ CN +SCP
Sbjct: 937 SACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQSCPPAWSAG--- 993
Query: 559 FPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECA---LVPDICFSTSKVPR 609
P A+CS +C G+ C+ + A L+PD ++ PR
Sbjct: 994 -PWAECSH---------TCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPR 1037
Score = 45.1 bits (105), Expect = 4e-04
Identities = 30/110 (27%), Positives = 39/110 (35%), Gaps = 20/110 (18%)
Query: 336 DSCTTCTCKKFKTICHQITCPPAT---CASPSFVEGECCPSCLHSVDGEEG-------WS 385
D C C + C P A C + G C G+EG WS
Sbjct: 536 DICKALWCHRIGRKCETKFMPAAEGTICGHDMWCRGGQCVKY-----GDEGPKPTHGHWS 590
Query: 386 PWAEWTQCSVTCGSGTQQRGRSCDVTSNT-----CLGPSIQTRACSLSKC 430
W+ W+ CS TCG G R R C + C G + + C+ KC
Sbjct: 591 DWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKC 640
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 82.4 bits (202), Expect = 2e-15
Identities = 106/445 (23%), Positives = 156/445 (35%), Gaps = 88/445 (19%)
Query: 326 FFAENETWVVDSCTTC--TCKKFKTICHQITCPPATCASPSFVEGECCPSCLHSVDGEE- 382
+ A W S T C TC K T ++C + S + C + V EE
Sbjct: 1179 YSAPRTQWRFGSWTPCSATCGK-GTRMRYVSCRDE---NGSVADESACATLPRPVAKEEC 1234
Query: 383 -----GWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSI--------QTRACSLSK 429
G +W+ CSVTCG G R C S+ + S + CS+S
Sbjct: 1235 SVTPCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSP 1294
Query: 430 CDTRIRQDG------------------------GWSHW--SPWSSCSVTCGVGNITRIRL 463
C R G G + W PW +CS TC G+ R+ +
Sbjct: 1295 CPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVV 1354
Query: 464 CNSPVPQMGGKNC--KGSGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVC 521
C +C + E +AC+ PCP +W+ + W CT C GGIR R VC
Sbjct: 1355 CQDENGYTAN-DCVERIKPDEQRACESGPCP---QWA-YGNWGECTKLCGGGIRTRLVVC 1409
Query: 522 N-SPEPQYGGKAC--VGDVQERQMCNKRSCPVDGCLSNPCFPGAQCSSFPDGSWSCGSCP 578
S ++ +C + +R+ CN +CP D S P + CS SC
Sbjct: 1410 QRSNGERFPDLSCEILDKPPDREQCNTHACPHDAAWSTG--PWSSCSV---------SCG 1458
Query: 579 VGFLGNGTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHCLPCPPRYRGNQPVGVGLEA 638
G +C D L D C +K P G C P+++ +
Sbjct: 1459 RGHKQRNVYCMAKDGSHLESDYCKHLAK-PHGHRKCRGGRC----PKWKAGAWSQCSVSC 1513
Query: 639 AKTEKQVCEPENPCKDKTHNCHKHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDS-DL 697
+ +Q C+ TH + EC ++ P + +CQ G C +
Sbjct: 1514 GRGVQQ---RHVGCQIGTHKIARETEC---NPYTRPESERDCQ------GPRCPLYTWRA 1561
Query: 698 DGWPNLNLVCATNATYH---CIKDN 719
+ W C + Y C+ DN
Sbjct: 1562 EEWQECTKTCGEGSRYRKVVCVDDN 1586
Score = 75.9 bits (185), Expect = 2e-13
Identities = 69/247 (27%), Positives = 88/247 (35%), Gaps = 57/247 (23%)
Query: 350 CHQITCPPAT--CASPSFVEGECCPSCLHSVDG--EEGWSPWAEWTQCSVTCGSGTQQRG 405
C+ T P T C PS P S W + WT CS TCG GT+ R
Sbjct: 1148 CNAATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWR-FGSWTPCSATCGKGTRMRY 1206
Query: 406 RSC--------DVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGN 457
SC D ++ L + CS++ C G W WSSCSVTCG G
Sbjct: 1207 VSCRDENGSVADESACATLPRPVAKEECSVTPC-------GQWKALD-WSSCSVTCGQGR 1258
Query: 458 ITRIRLC-NSPVPQMGGKNCKGS--GRETKACQGAPCP---------------------- 492
TR +C N + C + C +PCP
Sbjct: 1259 ATRQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRS 1318
Query: 493 --------IDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQ--ERQM 542
+ G PW AC+ TCAGG + R VC E Y CV ++ E++
Sbjct: 1319 ASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQD-ENGYTANDCVERIKPDEQRA 1377
Query: 543 CNKRSCP 549
C CP
Sbjct: 1378 CESGPCP 1384
Score = 67.8 bits (164), Expect = 6e-11
Identities = 37/107 (34%), Positives = 50/107 (46%), Gaps = 22/107 (20%)
Query: 385 SPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWS 444
+PWA+ T+C + G+ C + C + D + DG W WS
Sbjct: 558 TPWADGTEC---------EPGKHC------------KYGFCVPKEMDVPVT-DGSWGSWS 595
Query: 445 PWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPC 491
P+ +CS TCG G T IR CN P P+ GGK C G + K+C PC
Sbjct: 596 PFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPC 642
Score = 67.8 bits (164), Expect = 6e-11
Identities = 27/55 (49%), Positives = 33/55 (60%)
Query: 494 DGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSC 548
DG W WSP+ C+ TC GGI+ R CN PEP+ GGK CVG + + CN C
Sbjct: 588 DGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPC 642
Score = 66.6 bits (161), Expect = 1e-10
Identities = 57/209 (27%), Positives = 79/209 (37%), Gaps = 33/209 (15%)
Query: 383 GWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPS-------IQTRACSLSKCDTRIR 435
GW ++ WT+CS +C GTQ+R C T N L S + + CS C
Sbjct: 1000 GWR-YSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVTIQRCSEFPCPQ--- 1055
Query: 436 QDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRET--KACQGAPCPI 493
W WS C VTCG G+ R C ++ + C + T + CQ C
Sbjct: 1056 ----WKS-GDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPEC-- 1108
Query: 494 DGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNK----RSCP 549
W PW C+VTC G + R C G V D + + + C
Sbjct: 1109 -ASWQA-GPWGQCSVTCGQGYQLRAVKC-----IIGTYMSVVDDNDCNAATRPTDTQDCE 1161
Query: 550 VDGCLSNPCFPGAQCSSF--PDGSWSCGS 576
+ C P P + S++ P W GS
Sbjct: 1162 LPSCHPPPAAPETRRSTYSAPRTQWRFGS 1190
Score = 65.9 bits (159), Expect = 2e-10
Identities = 51/181 (28%), Positives = 76/181 (41%), Gaps = 42/181 (23%)
Query: 389 EWTQCSVTCGSGTQQR-------------GRSCDVTSNTCLGPSIQTRACSLSKCDTRIR 435
EW +C+ TCG G++ R G CDV+ + +CSL C+
Sbjct: 1563 EWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKR-----PVDRESCSLQPCEY--- 1614
Query: 436 QDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGA------ 489
W WS CSVTCG G R+ C+ G +N + S + T C G
Sbjct: 1615 ---VWI-TGEWSECSVTCGKGYKQRLVSCSE--IYTGKENYEYSYQTTINCPGTQPPSVH 1668
Query: 490 -----PCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDV--QERQM 542
CP+ W + W +C+V+C G+ +R+ C + E Q C D+ +ER+
Sbjct: 1669 PCYLRDCPVSATWRVGN-WGSCSVSCGVGVMQRSVQCLTNEDQ-PSHLCHTDLKPEERKT 1726
Query: 543 C 543
C
Sbjct: 1727 C 1727
Score = 62.4 bits (150), Expect = 2e-09
Identities = 88/347 (25%), Positives = 126/347 (36%), Gaps = 77/347 (22%)
Query: 390 WTQCSVTCGSGTQQRGRSCDVTSN-----TCLGPSIQ---TRACSLSKCDTRIRQDGGWS 441
W+QCSV+CG G QQR C + ++ T P + R C +C W
Sbjct: 1506 WSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYT-----W- 1559
Query: 442 HWSPWSSCSVTCGVGNITRIRLC-NSPVPQMGGKNCKGSGR--ETKACQGAPCPIDGRWS 498
W C+ TCG G+ R +C + ++ G C S R + ++C PC + W
Sbjct: 1560 RAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC--EYVWI 1617
Query: 499 PWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKA-----------CVG-DVQERQMCNKR 546
WS C+VTC G ++R C+ Y GK C G C R
Sbjct: 1618 T-GEWSECSVTCGKGYKQRLVSCSE---IYTGKENYEYSYQTTINCPGTQPPSVHPCYLR 1673
Query: 547 SCPVDGCLSNPCFPGAQCSSFPDGSW-SCG-SCPVGFLGNGTHC---EDLDECALVPDIC 601
CPV +++ G+W SC SC VG + C ED D+
Sbjct: 1674 DCPVS-------------ATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLK 1720
Query: 602 FSTSKVPRCV-NTQPGFHCLPCPPRYRGNQPVG---------------VGLEAAKTEKQV 645
K R V N + +C R +G G G+ + ++ V
Sbjct: 1721 PEERKTCRNVYNCELPQNCKEV-KRLKGASEDGEYFLMIRGKLLKIFCAGMHSDHPKEYV 1779
Query: 646 C----EPENPCKDKTHNCHKHAECIYLGHFSDPMYKCECQTGYAGDG 688
+ EN + H H EC Y G D C+C+ Y G
Sbjct: 1780 TLVHGDSENFSEVYGHRLHNPTECPYNGSRRD---DCQCRKDYTAAG 1823
Score = 60.8 bits (146), Expect = 7e-09
Identities = 51/192 (26%), Positives = 75/192 (39%), Gaps = 27/192 (14%)
Query: 388 AEWTQCSVTCGSG-----------TQQRGRSCDVTSNTCLG-PSIQTRACSLSKCDTRIR 435
A ++CS CG G ++ G++ V C P R +C+T
Sbjct: 942 ASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNT--- 998
Query: 436 QDGGWSHWSPWSSCSVTCGVGNITRIRLC-NSPVPQMGGKNCKGSGRET-KACQGAPCPI 493
GGW +S W+ CS +C G R +C N+ + C + T + C PCP
Sbjct: 999 --GGW-RYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVTIQRCSEFPCP- 1054
Query: 494 DGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVDGC 553
+W WS C VTC G + R C E + + C + + M ++C C
Sbjct: 1055 --QWKS-GDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSM---QTCQQPEC 1108
Query: 554 LSNPCFPGAQCS 565
S P QCS
Sbjct: 1109 ASWQAGPWGQCS 1120
Score = 50.4 bits (119), Expect = 1e-05
Identities = 54/211 (25%), Positives = 78/211 (36%), Gaps = 58/211 (27%)
Query: 389 EWTQCSVTCGSGTQQRGRSCD-------------VTSNTCLG---PSIQTRACSLSKCDT 432
EW++CSVTCG G +QR SC T+ C G PS+ C L C
Sbjct: 1620 EWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSV--HPCYLRDCPV 1677
Query: 433 RIRQDGGWSHWSPWSSCSVTCGVGNITR-----------IRLCNSPVPQMGGKNCKG--- 478
G W SCSV+CGVG + R LC++ + K C+
Sbjct: 1678 SATWRVG-----NWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVYN 1732
Query: 479 -----SGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQ------ 527
+ +E K +GA DG + + CAG +S P+
Sbjct: 1733 CELPQNCKEVKRLKGA--SEDGEYFLMIRGKLLKIFCAG--------MHSDHPKEYVTLV 1782
Query: 528 YGGKACVGDVQERQMCNKRSCPVDGCLSNPC 558
+G +V ++ N CP +G + C
Sbjct: 1783 HGDSENFSEVYGHRLHNPTECPYNGSRRDDC 1813
Score = 35.8 bits (81), Expect = 0.25
Identities = 17/68 (25%), Positives = 29/68 (42%), Gaps = 5/68 (7%)
Query: 368 GECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVT-----SNTCLGPSIQT 422
G C P + + W W+ + CS TCG G + R C+ C+G ++
Sbjct: 575 GFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKF 634
Query: 423 RACSLSKC 430
++C+ C
Sbjct: 635 KSCNTEPC 642
Score = 31.2 bits (69), Expect = 6.1
Identities = 22/68 (32%), Positives = 29/68 (42%), Gaps = 13/68 (19%)
Query: 497 WSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVDGCLSN 556
W+ PW AC+ C G R+R VC Q V D Q C++ P G ++
Sbjct: 881 WNSHGPWQACSKPCQGE-RKRKLVCTRESDQ----LTVSD----QRCDR--LPQPGHITE 929
Query: 557 PCFPGAQC 564
PC G C
Sbjct: 930 PC--GTDC 935
>gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
sapiens]
Length = 1074
Score = 82.0 bits (201), Expect = 3e-15
Identities = 102/385 (26%), Positives = 132/385 (34%), Gaps = 104/385 (27%)
Query: 361 ASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSC---------DVT 411
ASP G CP + EWT CS +CG GTQ R C V
Sbjct: 713 ASPEPCHGTPCPPYWEA----------GEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVP 762
Query: 412 SNTC---LGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITR-IRLCNSP 467
C P+I T++C L C G W SPWS CSV CG G +R +R +
Sbjct: 763 PERCGHLPRPNI-TQSCQLRLC-------GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNN 814
Query: 468 VPQMGGKNCKGSGRE---TKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSP 524
++ + C + +AC PC S WS S C+ C GI+ R+ VC
Sbjct: 815 GDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWS--SKCSAECGTGIQRRSVVCLGS 872
Query: 525 EPQYGGKACVGDVQERQMCNKRSCPVD--GCLSNPC--------FPGAQCSSFPDGSWSC 574
G Q C S P D C PC P +CSS C
Sbjct: 873 GAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCERTWRWYTGPWGECSS------EC 926
Query: 575 GS-------CPVGFLGNGTHCEDLDECALVP--------------DICFSTSKVPRCVNT 613
GS V LG + C+ +P D FST P +
Sbjct: 927 GSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQACQDRWFSTPWSPCSRSC 986
Query: 614 QPG-----FHCLP--------CPPRYRGNQPVGVGLEAAKTEKQVC--EPENPCKDKTHN 658
Q G CL CPP+ R ++ Q C P++ CKD + +
Sbjct: 987 QGGTQTREVQCLSTNQTLSTRCPPQLRPSR-------KRPCNSQPCSQRPDDQCKDSSPH 1039
Query: 659 CHKHAE---CIYLGHFSDPMYKCEC 680
C + C+Y P Y C
Sbjct: 1040 CPLVVQARLCVY------PYYTATC 1058
Score = 47.4 bits (111), Expect = 8e-05
Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 1/55 (1%)
Query: 357 PATCASPSFVEGECCPSCLHSVDGEEG-WSPWAEWTQCSVTCGSGTQQRGRSCDV 410
P C + G + G EG W PW +W CS CG G Q+R R+C +
Sbjct: 19 PQLCLDQEVLSGHSLQTPTEEGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQL 73
Score = 40.8 bits (94), Expect = 0.008
Identities = 13/34 (38%), Positives = 20/34 (58%)
Query: 494 DGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQ 527
+G W PW W++C+ C G++ R+R C P Q
Sbjct: 44 EGVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQ 77
Score = 40.0 bits (92), Expect = 0.013
Identities = 16/35 (45%), Positives = 19/35 (54%)
Query: 437 DGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQM 471
+G W W W+SCS CGVG R R C P Q+
Sbjct: 44 EGVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQL 78
Score = 40.0 bits (92), Expect = 0.013
Identities = 26/89 (29%), Positives = 40/89 (44%), Gaps = 11/89 (12%)
Query: 447 SSCSVTCGVGNITRIRLCNS--PVPQMGGKNCKGSGR---ETKACQGAPCPIDGRWSPWS 501
S+CS +CG G I LC S ++ ++C R + C G PCP W
Sbjct: 674 SACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCP--PYWEA-G 730
Query: 502 PWSACTVTCAGGIRERTRVCNSPEPQYGG 530
W++C+ +C G + R C ++GG
Sbjct: 731 EWTSCSRSCGPGTQHRQLQCRQ---EFGG 756
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 80.9 bits (198), Expect = 7e-15
Identities = 66/236 (27%), Positives = 90/236 (38%), Gaps = 52/236 (22%)
Query: 468 VPQMGGKNCKGSGRETKACQGAPC--------PIDGRWSPWSPWSACTVTCAGGIRERTR 519
VP G +C G G C+ C P++G W PW P+S+C+ TC GGI TR
Sbjct: 526 VPPADGTDC-GPGMH---CRHGLCVNKETETRPVNGEWGPWEPYSSCSRTCGGGIESATR 581
Query: 520 VCNSPEPQYGGKACVGDVQERQMCNKRSCPVDGCLSNPCFPGAQCSSFPDGSWSCGSCPV 579
CN PEP+ GG CVG + + CN SCP F QCS F
Sbjct: 582 RCNRPEPRNGGNYCVGRRMKFRSCNTDSCP----KGTQDFREKQCSDF------------ 625
Query: 580 GFLGNGTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHCLPCPPRYRGNQPVGVGLEAA 639
NG H + S +P V P + + R + V G
Sbjct: 626 ----NGKHLD--------------ISGIPSNVRWLPRYSGIGTKDRCKLYCQV-AGTNYF 666
Query: 640 KTEKQVCEPENPCKDKTHNCHKHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDS 695
K + E PC +TH+ +C+ G D + + G +CG D+
Sbjct: 667 YLLKDMVEDGTPCGTETHDICVQGQCMAAG--CDHVLNSSAKIDKCG---VCGGDN 717
Score = 66.2 bits (160), Expect = 2e-10
Identities = 55/183 (30%), Positives = 72/183 (39%), Gaps = 31/183 (16%)
Query: 387 WAEWTQCSVTCGSGTQQRGRSC------DVTSNTCLGPSIQTRA-CSLSKCDTRIRQDGG 439
++EW+QCS +CG G + R C + N C S TR C+ C +
Sbjct: 972 YSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVTRENCNEFSCPS------- 1024
Query: 440 WSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCPID--GRW 497
W+ S WS C VTCG G R C V + C S TK +PC + W
Sbjct: 1025 WAA-SEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSS---TKPESLSPCELHTCASW 1080
Query: 498 SPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVD--GCLS 555
PW CT TC G + R C + V E C++ S P D C+
Sbjct: 1081 QV-GPWGPCTTTCGHGYQMRDVKCVN--------ELASAVLEDTECHEASRPSDRQSCVL 1131
Query: 556 NPC 558
PC
Sbjct: 1132 TPC 1134
Score = 59.3 bits (142), Expect = 2e-08
Identities = 31/81 (38%), Positives = 41/81 (50%), Gaps = 3/81 (3%)
Query: 414 TCLGPSIQTR--ACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQM 471
T GP + R C + +TR +G W W P+SSCS TCG G + R CN P P+
Sbjct: 532 TDCGPGMHCRHGLCVNKETETR-PVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRN 590
Query: 472 GGKNCKGSGRETKACQGAPCP 492
GG C G + ++C CP
Sbjct: 591 GGNYCVGRRMKFRSCNTDSCP 611
Score = 58.2 bits (139), Expect = 5e-08
Identities = 62/280 (22%), Positives = 99/280 (35%), Gaps = 42/280 (15%)
Query: 350 CHQITCPPA------TCASPSFVEGECCPSCLHSVDGEEG-------WSPW--AEWTQCS 394
C CPPA + PS+ P D E + W W CS
Sbjct: 1258 CSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCS 1317
Query: 395 VTCGSGTQQRGRSC-DVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWS--PWSSCSV 451
+C G Q R C D + ++ L +C G W+ W CS
Sbjct: 1318 SSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGP-----GPCPQWNYGNWGECSQ 1372
Query: 452 TCGVGNITRIRLCNSPVPQ-MGGKNCKGSGRETKA--CQGAPCPIDGRWSPWSPWSACTV 508
TCG G +R+ +C P Q + NC+ + C CP D W PW++C+
Sbjct: 1373 TCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPADVSWHQ-EPWTSCSA 1431
Query: 509 TCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVDGCLSNPCFPGAQCSSFP 568
+C G + R C D +R++ + V ++ +C S+
Sbjct: 1432 SCGKGRKYREVFCI-------------DQFQRKLEDTNCSQVQKPPTHKACRSVRCPSWK 1478
Query: 569 DGSWS-CG-SCPVGFLGNGTHCEDLDECALVPDICFSTSK 606
SW+ C +C G +C +V ++C +++
Sbjct: 1479 ANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTR 1518
Score = 57.8 bits (138), Expect = 6e-08
Identities = 67/282 (23%), Positives = 94/282 (33%), Gaps = 68/282 (24%)
Query: 389 EWTQCSVTCGSGTQQRGRSC-----DVTSNTCLGPSIQT---RACSLSKCD--------- 431
+W+ CS +CG G R C + N C P ++ + CSL+ C
Sbjct: 1215 DWSPCSASCGHGKTTRQVLCMNYHQPIDENYC-DPEVRPLMEQECSLAACPPAHSHFPSS 1273
Query: 432 --------------TRIRQD-----------GGWSHWSPWSSCSVTCGVGNITRIRLCNS 466
T+ +D G PW SCS +C G R +C
Sbjct: 1274 PVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQD 1333
Query: 467 PVPQMGGKNCKGSGR--ETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSP 524
Q C + + E + C PCP +W+ + W C+ TC GGI+ R +C P
Sbjct: 1334 ENGQ-SASYCDAASKPPELQQCGPGPCP---QWN-YGNWGECSQTCGGGIKSRLVICQFP 1388
Query: 525 EPQY---GGKACVGDVQERQMCNKRSCPVDGCLSNPCFPGAQCSSFPDGSWSCGSCPVGF 581
Q V C+ +CP D +S P CS+ SC G
Sbjct: 1389 NGQILEDHNCEIVNKPPSVIQCHMHACPAD--VSWHQEPWTSCSA---------SCGKGR 1437
Query: 582 LGNGTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHCLPCP 623
C D + L C K P T + CP
Sbjct: 1438 KYREVFCIDQFQRKLEDTNCSQVQKPP----THKACRSVRCP 1475
Score = 55.5 bits (132), Expect = 3e-07
Identities = 58/220 (26%), Positives = 82/220 (37%), Gaps = 38/220 (17%)
Query: 363 PSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQ-----------QRGRSCDVT 411
PSFV C C E W + ++CS CG G + G++ V
Sbjct: 893 PSFVTQSCNTDC------ELRWHVIGK-SECSSQCGQGYRTLDIHCMKYSIHEGQTVQVD 945
Query: 412 SNTC---LGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLC-NSP 467
+ C L P Q C + TR W H+S WS CS +CG G +R C N+
Sbjct: 946 DHYCGDQLKPPTQ-ELCHGNCVFTR------W-HYSEWSQCSRSCGGGERSRESYCMNNF 997
Query: 468 VPQMGGKNCKGSGRETKA-CQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEP 526
++ C+ R T+ C CP W+ S WS C VTC G ++R C
Sbjct: 998 GHRLADNECQELSRVTRENCNEFSCP---SWAA-SEWSECLVTCGKGTKQRQVWCQLNVD 1053
Query: 527 QYGGKACVGDVQERQMCNKRSCPVDGCLSNPCFPGAQCSS 566
C + + C + C S P C++
Sbjct: 1054 HLSDGFCNSSTKPESL---SPCELHTCASWQVGPWGPCTT 1090
Score = 54.7 bits (130), Expect = 5e-07
Identities = 67/297 (22%), Positives = 106/297 (35%), Gaps = 55/297 (18%)
Query: 387 WA--EWTQCSVTCGSGTQQRGRSCD-----VTSNTCLGPSIQTRACSLSKCDTRIRQDGG 439
WA EW++C VTCG GT+QR C ++ C + T+ SLS C+ +
Sbjct: 1025 WAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFC---NSSTKPESLSPCE--LHTCAS 1079
Query: 440 WSHWSPWSSCSVTCGVGNITRIRLCNSPVPQ--MGGKNCKGSGR--ETKACQGAPCP--- 492
W PW C+ TCG G R C + + + C + R + ++C PC
Sbjct: 1080 W-QVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFIS 1138
Query: 493 ----------IDGRWSPW--SPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQER 540
+ + + W W+ C+V+C G + R C + + + +
Sbjct: 1139 KLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSC---------RDALDRIADE 1189
Query: 541 QMCNKRSCPVDGCLSNPCFPGAQCSSFPDGSWS--CGSCPVGFLGNGTHC----EDLDEC 594
C P + CF C + G WS SC G C + +DE
Sbjct: 1190 SYCAHLPRPAE---IWDCF--TPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDEN 1244
Query: 595 ALVPDI---CFSTSKVPRCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEP 648
P++ + C F P P Y + + + + E QV P
Sbjct: 1245 YCDPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHP 1301
Score = 43.9 bits (102), Expect = 0.001
Identities = 20/58 (34%), Positives = 30/58 (51%), Gaps = 7/58 (12%)
Query: 378 VDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVT-----SNTCLGPSIQTRACSLSKC 430
V+GE W PW ++ CS TCG G + R C+ N C+G ++ R+C+ C
Sbjct: 555 VNGE--WGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSC 610
Score = 43.5 bits (101), Expect = 0.001
Identities = 75/336 (22%), Positives = 116/336 (34%), Gaps = 72/336 (21%)
Query: 306 ELIGGPPKTR--NMSACWQDGRFFAENETWVVDSCTTCTCKKFKTI-------------- 349
E++ PP +M AC D + E W S + +K++ +
Sbjct: 1399 EIVNKPPSVIQCHMHACPADVSW--HQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTN 1456
Query: 350 CHQITCPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSC- 408
C Q+ PP A S CPS W W +CSVTCGSG QQR C
Sbjct: 1457 CSQVQKPPTHKACRSVR----CPS----------WKA-NSWNECSVTCGSGVQQRDVYCR 1501
Query: 409 -----DVTSNTCLGPSIQTRACSLSKCDTR-IRQDGGWSHWSPWSSCSVTC-GVGNITRI 461
V C TR CS +C ++ Q G +CS +C + R+
Sbjct: 1502 LKGVGQVVEEMC---DQSTRPCSQRRCWSQDCVQHKGMERGR--LNCSTSCERKDSHQRM 1556
Query: 462 RLCNSPVPQMGG--KNCKGSGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTR 519
++ + Q+ N +K C+ PC + S C C R+R
Sbjct: 1557 ECTDNQIRQVNEIVYNSSTISLTSKNCRNPPC---NYIVVTADSSQCANNCGFSYRQRIT 1613
Query: 520 VCNSPEPQYGGKACVGDVQERQMCNKRSCPVDGCLSNPCFPGAQC-------SSFPDGSW 572
C + ++ ++ R C P QC +++ G W
Sbjct: 1614 YCTE----------IPSTKKHKLHRLRPIVYQECPVVPSSQVYQCINSCLHLATWKVGKW 1663
Query: 573 S-CG-SCPVGFLGNGTHCEDLDECALVPDICFSTSK 606
S C +C +G + C + + L D+C + K
Sbjct: 1664 SKCSVTCGIGIMKRQVKC--ITKHGLSSDLCLNHLK 1697
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 79.7 bits (195), Expect = 1e-14
Identities = 62/186 (33%), Positives = 86/186 (46%), Gaps = 36/186 (19%)
Query: 542 MCNKRSCP-VDGCLSNPCF-PGAQCSSFPDGSWSCGSCPVGFLGNGTH--CEDLDECALV 597
M ++RSC +D C NP G QC++ P G + C C GF+ + C D++EC L
Sbjct: 1230 MPDQRSCTDIDECEDNPNICDGGQCTNIP-GEYRC-LCYDGFMASEDMKTCVDVNECDLN 1287
Query: 598 PDICFSTSKVPRCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCKDKTH 657
P+IC S + C NT+ F C C Y G K K C N C+ H
Sbjct: 1288 PNICLSGT----CENTKGSFIC-HCDMGYSG-----------KKGKTGCTDINECEIGAH 1331
Query: 658 NCHKHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNLNLVCATNA------ 711
NC KHA C + +KC C G+ GDG+ C +DLD N +C+ +A
Sbjct: 1332 NCGKHAVCTN----TAGSFKCSCSPGWIGDGIKC---TDLDECSNGTHMCSQHADCKNTM 1384
Query: 712 -TYHCI 716
+Y C+
Sbjct: 1385 GSYRCL 1390
Score = 61.2 bits (147), Expect = 5e-09
Identities = 85/355 (23%), Positives = 135/355 (38%), Gaps = 80/355 (22%)
Query: 510 CAGGIRERTR---VCNSPEPQYGGKACVG--DVQERQMCNKRSCPVDGCLSNPCFPGAQC 564
C G E T+ +C+ G K G D+ E C + ++ C A C
Sbjct: 1291 CLSGTCENTKGSFICHCDMGYSGKKGKTGCTDINE--------CEIG---AHNCGKHAVC 1339
Query: 565 SSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHCLPCPP 624
++ GS+ C SC G++G+G C DLDEC+ +C S+ C NT + CL C
Sbjct: 1340 TNTA-GSFKC-SCSPGWIGDGIKCTDLDECSNGTHMC---SQHADCKNTMGSYRCL-CKE 1393
Query: 625 RYRGNQPVGVGLEAAKTEKQVCEPENPCKDKTHNCHKHAECIYLGHFSDPMYKCECQTGY 684
Y G + C + C + + C + +C+ + Y+CEC G+
Sbjct: 1394 GYTG-------------DGFTCTDLDECSENLNLC-GNGQCLN----APGGYRCECDMGF 1435
Query: 685 --AGDGLICGEDSDLDGWPNLNLVCATNATYHCIKDNCPHLPNSGQ------EDFDKDGI 736
+ DG C ED D PN+ C+ C +LP + + D+ G
Sbjct: 1436 VPSADGKAC-EDIDECSLPNI-----------CVFGTCHNLPGLFRCECEIGYELDRSG- 1482
Query: 737 GDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKDEVGDRCDNCP--YVHNPAQIDTDNNG 794
G+ D ++ D T NC + G +CP + NP ++ +
Sbjct: 1483 GNCTDVNECLDPTTCISGNC------------VNTPGSYICDCPPDFELNPTRVGCVDTR 1530
Query: 795 EGDACSVDI----DGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPD 845
G+ C +DI D D + V + G G C+ CP V+ +
Sbjct: 1531 SGN-CYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSE 1584
Score = 60.5 bits (145), Expect = 9e-09
Identities = 83/318 (26%), Positives = 125/318 (39%), Gaps = 68/318 (21%)
Query: 551 DGC-LSNPCFPGAQCSSFPDGSWSCGSCPVGFL-GNGTHCEDLDECALVPDICFSTSKVP 608
D C + NPC G C + G + C +C GF G CED++ECA P +C
Sbjct: 2168 DECSVGNPCGNGT-CKNVI-GGFEC-TCEEGFEPGPMMTCEDINECAQNPLLC-----AF 2219
Query: 609 RCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCKDKTHNC-HKHAECIY 667
RCVNT + C CP Y + ++++C+ E+ C++ H+C K EC
Sbjct: 2220 RCVNTYGSYEC-KCPVGY-----------VLREDRRMCKDEDECEEGKHDCTEKQMECKN 2267
Query: 668 LGHFSDPMYKCECQTGY--AGDGLICGEDSDLDGWPNL--NLVCA-TNATYHC-IKDNCP 721
L Y C C GY DG C ++++ P + N C T +Y C D
Sbjct: 2268 L----IGTYMCICGPGYQRRPDGEGCVDENECQTKPGICENGRCLNTRGSYTCECNDGFT 2323
Query: 722 HLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKDEV--------G 773
PN D C D+ + T+ N + + + K E G
Sbjct: 2324 ASPNQ-----------DECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWG 2372
Query: 774 DRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGD 833
C+ CP+ A +G G +G D+ D C +++ + +G+ V D
Sbjct: 2373 PHCEICPFQGTVAFKKLCPHGRG----FMTNGADI----DECKVIHDVCR---NGECVND 2421
Query: 834 ----HCDNCPLVHNPDQT 847
HC C + PD T
Sbjct: 2422 RGSYHC-ICKTGYTPDIT 2438
Score = 60.1 bits (144), Expect = 1e-08
Identities = 70/247 (28%), Positives = 100/247 (40%), Gaps = 47/247 (19%)
Query: 546 RSC-PVDGCLSNP--CFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDICF 602
R+C ++ CL P C PG C + DGS+ C CP G+ CED+DEC P+IC
Sbjct: 1969 RTCVDINECLLEPRKCAPGT-CQNL-DGSYRC-ICPPGYSLQNEKCEDIDECVEEPEIC- 2024
Query: 603 STSKVPRCVNTQPGFHCLPCPPRY------RGNQPVGVGLEAAKTEKQVCEPENPCKDKT 656
+ C NT+ F CL CP + R Q + + AK E C K+
Sbjct: 2025 ---ALGTCSNTEGSFKCL-CPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCS-----SPKS 2075
Query: 657 HNCHKHAECIYL--GHFSDPMYKCECQTGYA-------GDGLICGEDS---DLDGWPNLN 704
N K C L + DP C + A G G+I G D D+D +
Sbjct: 2076 RNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDECKEPD 2135
Query: 705 LVCA------TNATYHCIKDNCPH---LPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDN 755
VC T+ +Y C CP L + D D+ +G+ C + + + +
Sbjct: 2136 -VCKHGQCINTDGSYRC---ECPFGYILAGNECVDTDECSVGNPCGNGTCKNVIGGFECT 2191
Query: 756 CQLLFNP 762
C+ F P
Sbjct: 2192 CEEGFEP 2198
Score = 55.5 bits (132), Expect = 3e-07
Identities = 51/173 (29%), Positives = 73/173 (42%), Gaps = 33/173 (19%)
Query: 550 VDGCLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGN--GTHCEDLDECALVPDICFSTSKV 607
VD C NPC G +C + GS++C C G+ T C D+DEC IC +
Sbjct: 491 VDECEKNPC-AGGECIN-NQGSYTC-QCRAGYQSTLTRTECRDIDECLQNGRICNN---- 543
Query: 608 PRCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCKDKTHNCHKHAECIY 667
RC+NT FHC+ G + K CE + C N + CI
Sbjct: 544 GRCINTDGSFHCV-----------CNAGFHVTRDGKN-CEDMDEC--SIRNMCLNGMCIN 589
Query: 668 LGHFSDPMYKCECQTGY--AGDGLICGEDSDLDGWPN--LNLVCA-TNATYHC 715
D +KC C+ G+ A DG C + ++ + P +N C T+ +Y C
Sbjct: 590 ----EDGSFKCICKPGFQLASDGRYCKDINECE-TPGICMNGRCVNTDGSYRC 637
Score = 54.7 bits (130), Expect = 5e-07
Identities = 81/304 (26%), Positives = 104/304 (34%), Gaps = 62/304 (20%)
Query: 351 HQITCPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSV-----TCGSGTQQRG 405
H P C S CCP GW QC V +CG G R
Sbjct: 50 HDALKGPNVCGSR--YNAYCCP----------GWKTLPGGNQCIVPICRHSCGDGFCSRP 97
Query: 406 RSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCS---VTCGVGNITRIR 462
C S + PS +R S+ C+ R G SCS C G I
Sbjct: 98 NMCTCPSGQ-IAPSCGSR--SIQHCNIRCMNGG---------SCSDDHCLCQKGYIGTH- 144
Query: 463 LCNSPVPQMG---GKNCKGSGRE--TKACQGAPCPIDGRWSPWSPWSA---CTVTCAGGI 514
C PV + G G C R T G C D R P + C +G +
Sbjct: 145 -CGQPVCESGCLNGGRCVAPNRCACTYGFTGPQCERDYRTGPCFTVISNQMCQGQLSGIV 203
Query: 515 RERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCP---------VDGCLSNPCF-PGAQC 564
+T C + +G C + C + P VD C + P G C
Sbjct: 204 CTKTLCCATVGRAWG-HPCEMCPAQPHPCRRGFIPNIRTGACQDVDECQAIPGLCQGGNC 262
Query: 565 SSFPDGSWSCGSCPVGFLGN--GTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHCLPC 622
+ GS+ C CP G N CED+DEC+ +P IC + C NT + C C
Sbjct: 263 INTV-GSFEC-KCPAGHKLNEVSQKCEDIDECSTIPGIC----EGGECTNTVSSYFC-KC 315
Query: 623 PPRY 626
PP +
Sbjct: 316 PPGF 319
Score = 52.4 bits (124), Expect = 3e-06
Identities = 91/404 (22%), Positives = 147/404 (36%), Gaps = 93/404 (23%)
Query: 550 VDGCLSNP-CFPGAQCSSFPDGSWSCGSCPVGFLGNGT-HCEDLDECALVPDICFSTSKV 607
+D C + P C A+C + GS+ C C G+ T C D +EC +P+IC
Sbjct: 1809 IDECQNGPVCQRNAECINTA-GSYRC-DCKPGYRFTSTGQCNDRNECQEIPNIC----SH 1862
Query: 608 PRCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCKDK--THNCHKHAEC 665
+C++T F+CL C ++ N + L+ + E+ C C++ + NC +
Sbjct: 1863 GQCIDTVGSFYCL-CHTGFKTNDDQTMCLDINECERDAC-GNGTCRNTIGSFNCRCNHGF 1920
Query: 666 IYLGHFSDPM------------------------YKCECQTGY--AGDGLICGEDSDLDG 699
I L H +D + ++C+C GY A DG C + ++
Sbjct: 1921 I-LSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLL 1979
Query: 700 WPNLNLVCA------TNATYHCIKDNCPHLPNSGQEDFDKDGIGDACDDDDD--NDGVTD 751
P CA + +Y CI L N ED D+ C ++ + G
Sbjct: 1980 EPR---KCAPGTCQNLDGSYRCICPPGYSLQNEKCEDIDE------CVEEPEICALGTCS 2030
Query: 752 EKDNCQLLFNPRQADYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNE 811
+ P + G RC + + A+ EG CS + +
Sbjct: 2031 NTEGSFKCLCPE--GFSLSSSGRRCQDLRMSYCYAKF------EGGKCSSPKSRN---HS 2079
Query: 812 RDNCPYVYNTDQRDTDGDGVGDHCDNCP----------------LVHNPDQTDVDND--L 853
+ C G+G GD C+ CP ++ PD + VD D
Sbjct: 2080 KQECCCALK-------GEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDECK 2132
Query: 854 VGDQCDNNEDIDDDGHQNNQDNCPYISNANQ-ADHDRDGQGDAC 896
D C + + I+ DG + YI N+ D D G+ C
Sbjct: 2133 EPDVCKHGQCINTDGSYRCECPFGYILAGNECVDTDECSVGNPC 2176
Score = 52.4 bits (124), Expect = 3e-06
Identities = 49/195 (25%), Positives = 77/195 (39%), Gaps = 42/195 (21%)
Query: 570 GSWSCGSCPVGFLGN--GTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHCLPCPPRYR 627
GS+ C C G+ + GT C DL+EC P C C NT+ + C CP Y
Sbjct: 2423 GSYHC-ICKTGYTPDITGTSCVDLNECNQAPKPCNFI-----CKNTEGSYQC-SCPKGY- 2474
Query: 628 GNQPVGVGLEAAKTEKQVCEPENPCKDKTHNCHKHAECI-YLGHFSDPMYKCECQTGYAG 686
+ + + C+ + C K HNC C+ +G F+ C+C G+
Sbjct: 2475 ----------ILQEDGRSCKDLDECATKQHNC--QFLCVNTIGGFT-----CKCPPGFTQ 2517
Query: 687 DGLICGEDSDLDGWPNLNLVCATNATYHCIKDNCPHLPNS----GQEDFDKDGIGDACDD 742
C ++++ C ++ K C + P S Q F D G +C+D
Sbjct: 2518 HHTSCIDNNE----------CTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCED 2567
Query: 743 DDDNDGVTDEKDNCQ 757
D+ +G + CQ
Sbjct: 2568 VDECEGNHRCQHGCQ 2582
Score = 49.3 bits (116), Expect = 2e-05
Identities = 39/118 (33%), Positives = 51/118 (43%), Gaps = 27/118 (22%)
Query: 570 GSWSCGSCPVGFLGNGTH--CEDLDECALVPDICFSTSKVPRCVNTQPGFHCLPCPPRYR 627
GS+ C CPVGF N CED+DEC P +C + C+NT + C C P YR
Sbjct: 1787 GSFRC-ECPVGFFYNDKLLVCEDIDECQNGP-VC---QRNAECINTAGSYRC-DCKPGYR 1840
Query: 628 GNQPVGVGLEAAKTEKQVCEPENPCKDKTHNCHKHAECI-YLGHFSDPMYKCECQTGY 684
T C N C++ + C H +CI +G F C C TG+
Sbjct: 1841 ------------FTSTGQCNDRNECQEIPNIC-SHGQCIDTVGSF-----YCLCHTGF 1880
Score = 48.5 bits (114), Expect = 4e-05
Identities = 42/148 (28%), Positives = 68/148 (45%), Gaps = 32/148 (21%)
Query: 550 VDGCLSNP--CFPGAQCSSFPDGSWSCGSCPVGF--LGNGTHCEDLDECALVPDICFSTS 605
+D CL N C G ++ DGS+ C C GF +G +CED+DEC+ + ++C +
Sbjct: 531 IDECLQNGRICNNGRCINT--DGSFHC-VCNAGFHVTRDGKNCEDMDECS-IRNMCLN-- 584
Query: 606 KVPRCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCKDKTHNCHKHAEC 665
C+N F C+ C P ++ ++ + C+ N C +T + C
Sbjct: 585 --GMCINEDGSFKCI-CKPGFQ-----------LASDGRYCKDINEC--ETPGICMNGRC 628
Query: 666 IYLGHFSDPMYKCECQTGYAG--DGLIC 691
+ +D Y+CEC G A DG +C
Sbjct: 629 VN----TDGSYRCECFPGLAVGLDGRVC 652
Score = 47.8 bits (112), Expect = 6e-05
Identities = 101/452 (22%), Positives = 164/452 (36%), Gaps = 75/452 (16%)
Query: 456 GNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCPID-GRWSPWSPWSACTVT---CA 511
G +T+ C + G+ C+ + A A C G S S + C + C
Sbjct: 676 GAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINECALDPDICP 735
Query: 512 GGIRERTR-----VCNSP-EPQYGGKACVGDVQERQMCNKRSCPVDGCLSNPCFPGAQCS 565
GI E R +CNS E GK CV D+ E C ++ L + QC
Sbjct: 736 NGICENLRGTYKCICNSGYEVDSTGKNCV-DINE--------CVLNSLLCD----NGQCR 782
Query: 566 SFPDGSWSCGSCPVGFLGNGT--HCEDLDECALVPDICFSTSKVPRCVN----TQPGFHC 619
+ P GS+ C +CP GF+ CED+DEC P C+N PG
Sbjct: 783 NTP-GSFVC-TCPKGFIYKPDLKTCEDIDECESSP-----------CINGVCKNSPGSFI 829
Query: 620 LPCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCKDKTHNCHKHAECIY-LGH-FSDPMYK 677
C + + +E K + C+ + ++C LG + P
Sbjct: 830 CECSSESTLDPTKTICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTL 889
Query: 678 CE----CQTGYAG-DGLICGEDSDLDGWPNL--NLVCA-TNATYHCIKDNCPHLPNSGQE 729
C+ C GY+ G C + + + +P + N +C T ++ C CP
Sbjct: 890 CQVDPICGKGYSRIKGTQCEDIDECEVFPGVCKNGLCVNTRGSFKC---QCP-------S 939
Query: 730 DFDKDGIGDACDDDD-DNDGVTDEKDNCQLLFNPR-QADYDKDEVG-----DRCDNCPYV 782
D G C D + + E + C L R + D VG + C+ CP
Sbjct: 940 GMTLDATGRICLDIRLETCFLRYEDEECTLPIAGRHRMDACCCSVGAAWGTEECEECPMR 999
Query: 783 HNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGD---HCDNCP 839
+ P + G G A +G F + + C + + + +G CD+
Sbjct: 1000 NTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLCTHGKCRNTIGSFKCRCDSGF 1059
Query: 840 LVHNPDQ--TDVDNDLVG-DQCDNNEDIDDDG 868
+ + ++ TD+D + D C + ++ G
Sbjct: 1060 ALDSEERNCTDIDECRISPDLCGRGQCVNTPG 1091
Score = 41.6 bits (96), Expect = 0.004
Identities = 62/240 (25%), Positives = 88/240 (36%), Gaps = 59/240 (24%)
Query: 570 GSWSCGSCPVGFL--GNGTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHCLPCPPRYR 627
GS+ C C GF +C D+DEC + PD+C +CVNT F C
Sbjct: 1049 GSFKC-RCDSGFALDSEERNCTDIDECRISPDLCGR----GQCVNTPGDFEC-------- 1095
Query: 628 GNQPVGVGLEAAKTEKQVCEPENPCKDKTHNCHKHAECIYLGHFSDPMYKCECQTGYAGD 687
G E+ + C + C+ C + C H ++ Y+CEC G+
Sbjct: 1096 ---KCDEGYESGFMMMKNCMDIDECQRDPLLC-RGGVC----HNTEGSYRCECPPGHQLS 1147
Query: 688 GLICG----EDSDLDG--WPN---LNLV----CATNATYH-------CIKDNCPHLPNSG 727
I + +L PN +NL+ CA N YH C+ + + N G
Sbjct: 1148 PNISACIDINECELSAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGG 1207
Query: 728 QEDFDKDGIGD---ACDDD----DDNDGVTDEKDNCQLLFNPRQADYDKDEVGDRCDNCP 780
E F + G +C D TD D C+ NP D G +C N P
Sbjct: 1208 CETFCTNSEGSYECSCQPGFALMPDQRSCTD-IDECE--DNPNICD------GGQCTNIP 1258
Score = 40.0 bits (92), Expect = 0.013
Identities = 27/95 (28%), Positives = 43/95 (45%), Gaps = 21/95 (22%)
Query: 590 DLDECALVPDICFSTSKVPRCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEPE 649
D+DEC +P +C + C+N F C CP + N + VCE
Sbjct: 1766 DIDECREIPGVCENGV----CINMVGSFRC-ECPVGFFYNDKL-----------LVCEDI 1809
Query: 650 NPCKDKTHNCHKHAECIYLGHFSDPMYKCECQTGY 684
+ C++ C ++AECI + Y+C+C+ GY
Sbjct: 1810 DECQNGP-VCQRNAECIN----TAGSYRCDCKPGY 1839
Score = 40.0 bits (92), Expect = 0.013
Identities = 76/320 (23%), Positives = 114/320 (35%), Gaps = 92/320 (28%)
Query: 544 NKRSCPVDGCLS---NPCFPGAQCSSFPDGSWSCGSCPVGF--LGNGTHCEDLDECALVP 598
N VD C S N C G QC + GS+ C C G+ +G C D++EC L P
Sbjct: 1925 NNDCIDVDECASGNGNLCRNG-QCINTV-GSFQC-QCNEGYEVAPDGRTCVDINECLLEP 1981
Query: 599 DICFSTSKVPRCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCKDKTHN 658
C + C N + C+ CPP Y + + CE + C ++
Sbjct: 1982 RKCAPGT----CQNLDGSYRCI-CPPGY-------------SLQNEKCEDIDECVEEPEI 2023
Query: 659 CHKHAECIYLGHFS--DPMYKCECQTGY--AGDGLICGEDSDLDGWPNLNLVCATNATYH 714
C LG S + +KC C G+ + G C DL + A +
Sbjct: 2024 C-------ALGTCSNTEGSFKCLCPEGFSLSSSGRRC---QDL-------RMSYCYAKFE 2066
Query: 715 CIKDNCPHLPNSGQED----FDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKD 770
K + P N +++ +G GD C+ P + D
Sbjct: 2067 GGKCSSPKSRNHSKQECCCALKGEGWGDPCE------------------LCPTEPDEAFR 2108
Query: 771 EVGDRCDNCPYVH------NPAQIDTDNNGEGDACS----VDIDGDDVFNERDNCPYVY- 819
++ CPY + + +D D E D C ++ DG + R CP+ Y
Sbjct: 2109 QI------CPYGSGIIVGPDDSAVDMDECKEPDVCKHGQCINTDG----SYRCECPFGYI 2158
Query: 820 --NTDQRDTDGDGVGDHCDN 837
+ DTD VG+ C N
Sbjct: 2159 LAGNECVDTDECSVGNPCGN 2178
Score = 38.9 bits (89), Expect = 0.029
Identities = 50/202 (24%), Positives = 70/202 (34%), Gaps = 35/202 (17%)
Query: 456 GNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIR 515
GN T + C P + G NC T CP D +P C T +G
Sbjct: 1483 GNCTDVNECLDPTTCISG-NCVN----TPGSYICDCPPDFELNPTRV--GCVDTRSGNCY 1535
Query: 516 ERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVDGCLSNPCFPGAQCSSFPDGSWSCG 575
R P G AC ++ C + PC C + +
Sbjct: 1536 LDIR----PRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPC---EMCPAVNTSEYKI- 1587
Query: 576 SCP--VGFLGNGTHC--EDLDECALVPDICFSTSKVPRCVNTQPGFHCLPCPPRYRGNQP 631
CP GF N ED+DEC +P +C + +C+NT F C CP Y N+
Sbjct: 1588 LCPGGEGFRPNPITVILEDIDECQELPGLC----QGGKCINTFGSFQC-RCPTGYYLNE- 1641
Query: 632 VGVGLEAAKTEKQVCEPENPCK 653
+ +VC+ N C+
Sbjct: 1642 ----------DTRVCDDVNECE 1653
Score = 37.7 bits (86), Expect = 0.065
Identities = 33/115 (28%), Positives = 45/115 (39%), Gaps = 23/115 (20%)
Query: 570 GSWSCGSCPVGFLGNGTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHCLPCPPRYRGN 629
G ++C CP GF + T C D +EC ++C S C NT F C C
Sbjct: 2505 GGFTC-KCPPGFTQHHTSCIDNNECTSDINLCGSKG---ICQNTPGSFTC-ECQR----- 2554
Query: 630 QPVGVGLEAAKTEKQVCEPENPCKDKTHNCHKHAECIYLGHFSDPMYKCECQTGY 684
G L+ + CE + C + H C + I G Y+C C GY
Sbjct: 2555 ---GFSLDQTGSS---CEDVDEC-EGNHRCQHGCQNIIGG------YRCSCPQGY 2596
Score = 33.9 bits (76), Expect = 0.93
Identities = 34/117 (29%), Positives = 45/117 (38%), Gaps = 26/117 (22%)
Query: 570 GSWSCGSCPVGFLGN--GTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHCLPCPPRYR 627
G + C SCP G+L + C D +EC L IC S C NT + C+ CP ++
Sbjct: 2586 GGYRC-SCPQGYLQHYQWNQCVDENEC-LSAHICGGAS----CHNTLGSYKCM-CPAGFQ 2638
Query: 628 GNQPVGVGLEAAKTEKQVCEPENPCKDKTHNCHKHAECIYLGHFSDPMYKCECQTGY 684
Q G C+ N C A C Y ++ Y C C GY
Sbjct: 2639 YEQFSGG-----------CQDINECGSA------QAPCSYGCSNTEGGYLCGCPPGY 2678
Score = 33.1 bits (74), Expect = 1.6
Identities = 62/259 (23%), Positives = 87/259 (33%), Gaps = 63/259 (24%)
Query: 461 IRLCNSPVPQMGGKNCKGSGRETKAC-QGAPCPIDGRWSPWSPWSACTVTCAGGIRERTR 519
I C +P M G+ G C G +DGR + + TC GG +
Sbjct: 614 INECETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRS---TCYGGYKRGQC 670
Query: 520 VCNSPEPQYGGKACVGDVQERQMCNKRSCPVDGCLSNPCFP---------GAQCSSFPDG 570
+ K G V + + C + PC P A CSS P G
Sbjct: 671 I----------KPLFGAVTKSECC---CASTEYAFGEPCQPCPAQNSAEYQALCSSGP-G 716
Query: 571 SWSCGSCPVGFLGNGTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHCLPCPPRYRGNQ 630
S GS D++ECAL PDIC + C N + + C+
Sbjct: 717 MTSAGS-------------DINECALDPDICPNGI----CENLRGTYKCI---------- 749
Query: 631 PVGVGLEAAKTEKQVCEPENPCKDKTHNCHKHAECIYLGHFSDPMYKCECQTG--YAGDG 688
G E T K C N C + C + +C + + C C G Y D
Sbjct: 750 -CNSGYEVDSTGKN-CVDINECVLNSLLC-DNGQC----RNTPGSFVCTCPKGFIYKPDL 802
Query: 689 LICGEDSDLDGWPNLNLVC 707
C + + + P +N VC
Sbjct: 803 KTCEDIDECESSPCINGVC 821
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 79.3 bits (194), Expect = 2e-14
Identities = 36/94 (38%), Positives = 48/94 (51%), Gaps = 12/94 (12%)
Query: 482 ETKACQGAPC--------PIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKAC 533
E K C C I G W WSPWS C+ TC G++ R+CN+PEP++GGK C
Sbjct: 522 EKKWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYC 581
Query: 534 VGDVQERQMCNKRSCPVDGCLSNPCFPGAQCSSF 567
G+ + ++CN C + P F QCS F
Sbjct: 582 TGERKRYRLCNVHPCRSEA----PTFRQMQCSEF 611
Score = 72.0 bits (175), Expect = 3e-12
Identities = 32/71 (45%), Positives = 39/71 (54%), Gaps = 4/71 (5%)
Query: 425 CSLSKCDTRIRQD----GGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSG 480
C KC T ++ GGW WSPWS CS TCG G + RLCN+P P+ GGK C G
Sbjct: 526 CMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGER 585
Query: 481 RETKACQGAPC 491
+ + C PC
Sbjct: 586 KRYRLCNVHPC 596
Score = 58.9 bits (141), Expect = 3e-08
Identities = 48/178 (26%), Positives = 70/178 (39%), Gaps = 25/178 (14%)
Query: 387 WAEWTQCSVTCGSGTQQRGRSC-----DVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWS 441
+ WT+CSVTCG+G +++ C + T P Q KC + W+
Sbjct: 830 YGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNG-RQKKCHEKACPPRWWA 888
Query: 442 HWSPWSSCSVTCGV-GNITRIRLC-------NSPVPQMGGKNCKGSGRETKACQGAPCPI 493
W +CS TCG G R LC +P ++ + CP
Sbjct: 889 --GEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPS 946
Query: 494 DGRWSPWSPWSACTVTCAGGIRERTRVC--NSPEPQYGGKACVGDVQERQMCNKRSCP 549
D W+ + WS C+V+C GG+R R+ C N EP R +C + CP
Sbjct: 947 D--WTVGN-WSECSVSCGGGVRIRSVTCAKNHDEP----CDVTRKPNSRALCGLQQCP 997
Score = 52.0 bits (123), Expect = 3e-06
Identities = 60/222 (27%), Positives = 82/222 (36%), Gaps = 48/222 (21%)
Query: 390 WTQCSVTCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSC 449
W++CS TCG G R C ++ +IQ R +C +R GW + WS C
Sbjct: 1322 WSECSTTCGLGAYWRRVECSTQMDSDCA-AIQ-RPDPAKRC--HLRPCAGWKVGN-WSKC 1376
Query: 450 SVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRWSP-----WS--P 502
S C G R C V +N + + A G P P+ +P W P
Sbjct: 1377 SRNCSGGFKIREIQC---VDSRDHRNLRPFHCQFLA--GIPPPLSMSCNPEPCEAWQVEP 1431
Query: 503 WSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVDGCLSNPCFPGA 562
WS C+ +C GG++ER G C G +C+ P N
Sbjct: 1432 WSQCSRSCGGGVQER------------GVFCPGG-----LCDWTKRPTSTMSCNEHL--- 1471
Query: 563 QCSSFPDGSWS-CG-SCPVGFLGNGTHC--------EDLDEC 594
C + G+W C SC GF C ED D+C
Sbjct: 1472 -CCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQC 1512
Score = 42.7 bits (99), Expect = 0.002
Identities = 18/53 (33%), Positives = 25/53 (47%), Gaps = 5/53 (9%)
Query: 383 GWSPWAEWTQCSVTCGSGTQQRGRSCD-----VTSNTCLGPSIQTRACSLSKC 430
GW W+ W+ CS TCG+G Q R C+ C G + R C++ C
Sbjct: 544 GWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPC 596
Score = 39.3 bits (90), Expect = 0.022
Identities = 30/106 (28%), Positives = 43/106 (40%), Gaps = 28/106 (26%)
Query: 431 DTRIRQDGGWSHWSPWSSCSVTCGVG-------------NITRIRLCNSPVPQMGGKNCK 477
D + Q + + W+ CSVTCG G + + C+ P Q G+
Sbjct: 818 DNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCD-PETQPNGRQ-- 874
Query: 478 GSGRETKACQGAPCPIDGRWSPWS-PWSACTVTCA-GGIRERTRVC 521
K C CP RW W+ W AC+ TC G ++RT +C
Sbjct: 875 ------KKCHEKACP--PRW--WAGEWEACSATCGPHGEKKRTVLC 910
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 77.4 bits (189), Expect = 7e-14
Identities = 32/78 (41%), Positives = 43/78 (55%), Gaps = 4/78 (5%)
Query: 490 PCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCP 549
P +DG W PW+PW C+ TC GG+ +R C+SP P GGK C+G+ + + CN CP
Sbjct: 543 PEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCP 602
Query: 550 VDGCLSNPCFPGAQCSSF 567
+ F QCS F
Sbjct: 603 P----GSQDFREVQCSEF 616
Score = 64.7 bits (156), Expect = 5e-10
Identities = 26/56 (46%), Positives = 32/56 (57%)
Query: 437 DGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCP 492
DG W W+PW CS TCG G + R C+SP P +GGK C G R ++C CP
Sbjct: 547 DGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCP 602
Score = 60.1 bits (144), Expect = 1e-08
Identities = 48/178 (26%), Positives = 69/178 (38%), Gaps = 20/178 (11%)
Query: 387 WAEWTQCSVTCGSGTQQRGRSC-DVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHW-- 443
+A WT+CS C G+Q + C + ++ + P + L K + W
Sbjct: 831 YAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVV 890
Query: 444 SPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRET------KACQGAPCPIDGRW 497
WS CS +C G +R +C V K S +AC G CP + W
Sbjct: 891 GNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCPPE--W 948
Query: 498 SPWSPWSACTVTCAGGIRERTRVCNSPE------PQYGGKACVGDVQERQMCNKRSCP 549
+ WS CT +C G+R R +C S + P + A R CN R CP
Sbjct: 949 AALD-WSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMR--CNLRRCP 1003
Score = 52.4 bits (124), Expect = 3e-06
Identities = 49/191 (25%), Positives = 75/191 (39%), Gaps = 24/191 (12%)
Query: 442 HWSPWSSCSVTCGVGNITRIRLCNSPV------PQMGGKNCKGSGRETKACQGAPCPIDG 495
H++PW+ CS C G+ + C + + P + K R+ +AC PCP D
Sbjct: 830 HYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQ-RACNTEPCPPD- 887
Query: 496 RWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPV-DGCL 554
W + WS C+ +C G+R R+ VC Q A + C + PV + C
Sbjct: 888 -WVVGN-WSLCSRSCDAGVRSRSVVC-----QRRVSAAEEKALDDSACPQPRPPVLEACH 940
Query: 555 SNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDI-CFSTSKVPRCVNT 613
C P + + + SCG G C+ D A +P C +K P +
Sbjct: 941 GPTCPPEWAALDWSECTPSCGP---GLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRC 997
Query: 614 QPGFHCLPCPP 624
+ CPP
Sbjct: 998 ----NLRRCPP 1004
Score = 50.4 bits (119), Expect = 1e-05
Identities = 30/101 (29%), Positives = 41/101 (40%), Gaps = 11/101 (10%)
Query: 341 CTCKKFKTICHQITCPPAT-CASPSFVEGEC----CPSCLHSVDGEEG-WSPWAEWTQCS 394
C K + I + I T C + + +G C C +G +G W PW W CS
Sbjct: 501 CLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPEGVDGAWGPWTPWGDCS 560
Query: 395 VTCGSGTQQRGRSCD-----VTSNTCLGPSIQTRACSLSKC 430
TCG G R CD + CLG + R+C+ C
Sbjct: 561 RTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDC 601
Score = 46.2 bits (108), Expect = 2e-04
Identities = 36/142 (25%), Positives = 56/142 (39%), Gaps = 10/142 (7%)
Query: 390 WTQCSVTCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWS--HWSP-- 445
W+ CS +C +G + R C + ++ AC + G W+
Sbjct: 893 WSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCPPEWAALD 952
Query: 446 WSSCSVTCGVGNITRIRLCNSPVPQ--MGGKNCKGSGRE--TKACQGAPCPIDGRWSPWS 501
WS C+ +CG G R+ LC S + + +C + + T C CP RW
Sbjct: 953 WSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCP-PARWVA-G 1010
Query: 502 PWSACTVTCAGGIRERTRVCNS 523
W C+ C G R+R+ C S
Sbjct: 1011 EWGECSAQCGVGQRQRSVRCTS 1032
Score = 43.5 bits (101), Expect = 0.001
Identities = 44/194 (22%), Positives = 67/194 (34%), Gaps = 47/194 (24%)
Query: 333 WVVDSCTTCT-------------CKKFKTICHQITCPPATCASPSFVEGECCPSCLHSVD 379
WVV + + C+ C++ + + + C P P L +
Sbjct: 888 WVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPR-------PPVLEACH 940
Query: 380 GEEGWSPWA--EWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSIQ---------TRACSLS 428
G WA +W++C+ +CG G + R C + P T C+L
Sbjct: 941 GPTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLR 1000
Query: 429 KCDTRIRQDGGWSHW--SPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGR--ETK 484
+C + W W CS CGVG R C S Q C + R T+
Sbjct: 1001 RCPP--------ARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQ-ASHECTEALRPPTTQ 1051
Query: 485 ACQG---APCPIDG 495
C+ +P P DG
Sbjct: 1052 QCEAKCDSPTPGDG 1065
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 76.6 bits (187), Expect = 1e-13
Identities = 44/121 (36%), Positives = 60/121 (49%), Gaps = 15/121 (12%)
Query: 480 GRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQE 539
G+ K + P PI G+WS WS WS C+ TC GG++ + R CN+P+PQYGG C G +
Sbjct: 575 GQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRI 634
Query: 540 RQMCNKRSCPVDGCLSNPC-FPGAQCSSF---PDGSWSCGSCPVGFLGNGTHCEDLDECA 595
Q+CN ++ C N F QC+ + P W P T E+ D C
Sbjct: 635 YQLCN-----INPCNENSLDFRAQQCAEYNSKPFRGWFYQWKPY------TKVEEEDRCK 683
Query: 596 L 596
L
Sbjct: 684 L 684
Score = 68.9 bits (167), Expect = 3e-11
Identities = 57/193 (29%), Positives = 76/193 (39%), Gaps = 38/193 (19%)
Query: 384 WSPWAEWTQCSVTCGSGTQQRGRSC----------DVTSNTC-LGPSIQTRACSLSKCDT 432
W P EW+ CS C G Q R C V + C + Q +AC+ C
Sbjct: 935 WMP-GEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPP 993
Query: 433 RIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCN-SPVPQMGGKNCKGSGRET--KACQGA 489
+ WS PWS CS TCG G R LC S + C R + C
Sbjct: 994 Q------WS-LGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLG 1046
Query: 490 PCPIDGRWSPW--SPWSACTVTCAGGIRERTRVCNSPEPQYGGKACV-----------GD 536
CP + R W S WS C+ TC G+R+R C+ E + GK +
Sbjct: 1047 RCPKNSRLQ-WVASSWSECSATCGLGVRKREMKCS--EKGFQGKLITFPERRCRNIKKPN 1103
Query: 537 VQERQMCNKRSCP 549
+ + CN+R+CP
Sbjct: 1104 LDLEETCNRRACP 1116
Score = 67.8 bits (164), Expect = 6e-11
Identities = 57/204 (27%), Positives = 79/204 (38%), Gaps = 44/204 (21%)
Query: 344 KKFKTICHQITCPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQ 403
+K + + H + CP +T CP WS W+QCS TCG G ++
Sbjct: 965 QKEEAVLHSL-CPVSTPTQVQACNSHACPP---------QWS-LGPWSQCSKTCGRGVRK 1013
Query: 404 RGRSCDVTSNTCLGPSIQT--------RACSLSKCDTRIRQDGGWSHW--SPWSSCSVTC 453
R C ++ L S T C L +C R W S WS CS TC
Sbjct: 1014 RELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQ-----WVASSWSECSATC 1068
Query: 454 GVGNITRIRLCNSP--------VPQMGGKNCKGSGRETK-ACQGAPCP-------IDGRW 497
G+G R C+ P+ +N K + + C CP + G +
Sbjct: 1069 GLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWY 1128
Query: 498 SPWSPWSACTVTCAGGIRERTRVC 521
S PW CTVTC GG++ R+ C
Sbjct: 1129 S--LPWQQCTVTCGGGVQTRSVHC 1150
Score = 61.2 bits (147), Expect = 5e-09
Identities = 28/54 (51%), Positives = 31/54 (57%)
Query: 438 GGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPC 491
G WS WS WS CS TCG G + R CN+P PQ GG C GS R + C PC
Sbjct: 590 GQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPC 643
Score = 58.2 bits (139), Expect = 5e-08
Identities = 52/208 (25%), Positives = 81/208 (38%), Gaps = 44/208 (21%)
Query: 391 TQCSVTCGSGTQQ------RGRSCDVTSNTCLG---PSIQTRACSLSKCDTRIRQDGGWS 441
++CSV+CG G R ++ V S+ C P + + C+ C +
Sbjct: 883 SECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCP---------A 933
Query: 442 HWSP--WSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGS------GRETKACQGAPCPI 493
+W P WS+CS C G +R C P + S + +AC CP
Sbjct: 934 YWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACP- 992
Query: 494 DGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCP--VD 551
+WS PWS C+ TC G+R+R +C K + C P +
Sbjct: 993 -PQWS-LGPWSQCSKTCGRGVRKRELLC---------KGSAAETLPESQCTSLPRPELQE 1041
Query: 552 GCLSNPCFPGAQ----CSSFPDGSWSCG 575
GC+ C ++ SS+ + S +CG
Sbjct: 1042 GCVLGRCPKNSRLQWVASSWSECSATCG 1069
Score = 43.9 bits (102), Expect = 0.001
Identities = 40/160 (25%), Positives = 61/160 (38%), Gaps = 40/160 (25%)
Query: 333 WVVDSCTTCTCKKFKTICHQITCPPAT---------CASPSFVE-GECCPSCLHSVDGEE 382
+V D C + C + C P A C V+ GE P +H
Sbjct: 536 FVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQ---- 591
Query: 383 GWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNT-----CLGPSIQTRACSLSKC-----DT 432
WS W++W++CS TCG G + + R C+ C G S + C+++ C D
Sbjct: 592 -WSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDF 650
Query: 433 RIRQDG--------GWSH-WSPWSS------CSVTCGVGN 457
R +Q GW + W P++ C + C N
Sbjct: 651 RAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAEN 690
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif,
6 preproprotein [Homo sapiens]
Length = 1117
Score = 76.3 bits (186), Expect = 2e-13
Identities = 44/138 (31%), Positives = 58/138 (42%), Gaps = 20/138 (14%)
Query: 446 WSSCSVTCGVGNITRIRLCNSP--------VPQMGGKNCKGSGRETKACQGAPC------ 491
+ + S C G + R C S +P G C+ E C C
Sbjct: 494 YGATSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTW 553
Query: 492 --PIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCP 549
IDG W PWS W C+ TC GG+ R C+SP P GGK C+G+ + + CN CP
Sbjct: 554 PQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCP 613
Query: 550 VDGCLSNPCFPGAQCSSF 567
L + F QC+ F
Sbjct: 614 ----LGSRDFREKQCADF 627
Score = 70.1 bits (170), Expect = 1e-11
Identities = 28/60 (46%), Positives = 35/60 (58%)
Query: 437 DGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGR 496
DGGW WS W CS TCG G + +R C+SP P GGK C G + ++C PCP+ R
Sbjct: 558 DGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSR 617
Score = 56.6 bits (135), Expect = 1e-07
Identities = 64/282 (22%), Positives = 103/282 (36%), Gaps = 62/282 (21%)
Query: 226 CQQGQGAEINAISENTETLRLGPHVTTEY-VGPSSERRPEVCERSCEELGNMVQELSGLH 284
C+ + IN E + LG T + +G + + SC G+ +L H
Sbjct: 381 CEPERSCSIN------EDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMAAH 434
Query: 285 VLVNQLSENLKRVSND--NQFLWE-----LIGGPPKTRNMSACWQDGRFFAENETWVVDS 337
+ N + S D FL L PPK + G+ + +E
Sbjct: 435 ITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRFQY 494
Query: 338 CTTCTCKKFKTICHQITCPPAT--CASPSF------------------VEGECCP--SCL 375
T K+ +C ++ C + C + S +G+C P +
Sbjct: 495 GATSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTWP 554
Query: 376 HSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNT-----CLGPSIQTRACSLSKC 430
S+DG GW PW+ W +CS TCG G R CD + + CLG + R+C+ C
Sbjct: 555 QSIDG--GWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPC 612
Query: 431 -----DTRIRQ---------DGGWSHWSPWSS-----CSVTC 453
D R +Q G + +W P++ C++ C
Sbjct: 613 PLGSRDFREKQCADFDNMPFRGKYYNWKPYTGGGVKPCALNC 654
Score = 55.5 bits (132), Expect = 3e-07
Identities = 69/270 (25%), Positives = 94/270 (34%), Gaps = 59/270 (21%)
Query: 377 SVDGEEGWSPWAE--WTQCSVTCGSGTQQRGRSCD-------VTSNTC---LGPSIQTRA 424
S D E G++ W W++CS TC G Q++ C V +N C P RA
Sbjct: 835 SGDNEVGFT-WNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRA 893
Query: 425 CSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSG---- 480
C+ C W W CS TC G TR LC + + SG
Sbjct: 894 CNTEPCPPE------W-FIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTH 946
Query: 481 --RETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPE--PQYGGKACVGD 536
E + C CP +W WS CT C G + R +C S + + C +
Sbjct: 947 RPVEKEPCNNQSCP--PQWVALD-WSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEE 1003
Query: 537 VQE--RQMCNKRSCPVD-------GCLSNPCFPG-----AQCSSF-------------PD 569
+ R C+ CP G S C G QC S+ P
Sbjct: 1004 SKPPVRIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPP 1063
Query: 570 GSWSCGS-CPVGFLGNGTHCEDLDECALVP 598
C S C + N C+D+++ A P
Sbjct: 1064 SMQQCESKCDSTPISNTEECKDVNKVAYCP 1093
Score = 32.7 bits (73), Expect = 2.1
Identities = 34/115 (29%), Positives = 45/115 (39%), Gaps = 18/115 (15%)
Query: 333 WVVDSCTTCTCKKFKTICHQITCPPATCASPSFVEGECC-----PSCLHSVDGEEGWSPW 387
WV + CT K H+I ++ S +F +C P + G W
Sbjct: 963 WVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRW 1022
Query: 388 A--EWTQCSVTCGSGTQQRGRSC----DVTSNTCL----GPSIQTRACSLSKCDT 432
+W QCS CG G Q R C S+ CL PS+Q C SKCD+
Sbjct: 1023 VTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQ--QCE-SKCDS 1074
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 75.9 bits (185), Expect = 2e-13
Identities = 27/56 (48%), Positives = 39/56 (69%)
Query: 494 DGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCP 549
DG WS W+ + +C+ +C GG+R R+R CN+P P YGG+ C+G + E Q+CN CP
Sbjct: 552 DGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECP 607
Score = 63.5 bits (153), Expect = 1e-09
Identities = 27/57 (47%), Positives = 34/57 (59%)
Query: 436 QDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCP 492
QDGGWS W+ + SCS +CG G +R R CN+P P GG+ C G E + C CP
Sbjct: 551 QDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECP 607
Score = 58.5 bits (140), Expect = 4e-08
Identities = 53/179 (29%), Positives = 70/179 (39%), Gaps = 25/179 (13%)
Query: 387 WA--EWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWS 444
WA W CS CG G Q C + + +Q C K IR+ S
Sbjct: 851 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHM---VQRHLCDHKKRPKPIRRRCNQHPCS 907
Query: 445 P-------WSSCSVTCG-VGNITRIRLCNSPVPQ-----MGGKNCKGSGRETKA-CQGAP 490
W +CS +CG +G TR C P+ M K C G E + C P
Sbjct: 908 QPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVP 967
Query: 491 CPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQER-QMCNKRSC 548
CP R WS C+ TC GI++R VC + G C GD + Q+C+ +C
Sbjct: 968 CPAQWRLGAWSQ---CSATCGEGIQQRQVVCRTNANSLG--HCEGDRPDTVQVCSLPAC 1021
Score = 52.4 bits (124), Expect = 3e-06
Identities = 36/117 (30%), Positives = 50/117 (42%), Gaps = 30/117 (25%)
Query: 342 TCKKFKTI--CHQITCP----PATCAS---PSFVEGECCPS-------CL-------HSV 378
TC F+T C Q+ C P C + P EC P C+ +
Sbjct: 492 TCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQ 551
Query: 379 DGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTS-----NTCLGPSIQTRACSLSKC 430
DG GWS W ++ CS +CG G + R RSC+ S CLGP + + C+ +C
Sbjct: 552 DG--GWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEEC 606
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1
motif, 14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 75.9 bits (185), Expect = 2e-13
Identities = 27/56 (48%), Positives = 39/56 (69%)
Query: 494 DGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCP 549
DG WS W+ + +C+ +C GG+R R+R CN+P P YGG+ C+G + E Q+CN CP
Sbjct: 555 DGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECP 610
Score = 63.5 bits (153), Expect = 1e-09
Identities = 27/57 (47%), Positives = 34/57 (59%)
Query: 436 QDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCP 492
QDGGWS W+ + SCS +CG G +R R CN+P P GG+ C G E + C CP
Sbjct: 554 QDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECP 610
Score = 58.5 bits (140), Expect = 4e-08
Identities = 53/179 (29%), Positives = 70/179 (39%), Gaps = 25/179 (13%)
Query: 387 WA--EWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWS 444
WA W CS CG G Q C + + +Q C K IR+ S
Sbjct: 854 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHM---VQRHLCDHKKRPKPIRRRCNQHPCS 910
Query: 445 P-------WSSCSVTCG-VGNITRIRLCNSPVPQ-----MGGKNCKGSGRETKA-CQGAP 490
W +CS +CG +G TR C P+ M K C G E + C P
Sbjct: 911 QPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVP 970
Query: 491 CPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQER-QMCNKRSC 548
CP R WS C+ TC GI++R VC + G C GD + Q+C+ +C
Sbjct: 971 CPAQWRLGAWSQ---CSATCGEGIQQRQVVCRTNANSLG--HCEGDRPDTVQVCSLPAC 1024
Score = 52.4 bits (124), Expect = 3e-06
Identities = 36/117 (30%), Positives = 50/117 (42%), Gaps = 30/117 (25%)
Query: 342 TCKKFKTI--CHQITCP----PATCAS---PSFVEGECCPS-------CL-------HSV 378
TC F+T C Q+ C P C + P EC P C+ +
Sbjct: 495 TCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQ 554
Query: 379 DGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTS-----NTCLGPSIQTRACSLSKC 430
DG GWS W ++ CS +CG G + R RSC+ S CLGP + + C+ +C
Sbjct: 555 DG--GWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEEC 609
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.137 0.453
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,917,335
Number of Sequences: 37866
Number of extensions: 2948347
Number of successful extensions: 10976
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 134
Number of HSP's successfully gapped in prelim test: 250
Number of HSP's that attempted gapping in prelim test: 6962
Number of HSP's gapped (non-prelim): 2081
length of query: 1172
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1059
effective length of database: 13,968,660
effective search space: 14792810940
effective search space used: 14792810940
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.