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Search of human proteins with 125656165
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|125656165 THO complex 2 [Homo sapiens]
(1593 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|125656165 THO complex 2 [Homo sapiens] 3208 0.0
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 100 9e-21
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 100 9e-21
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 100 2e-20
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 97 1e-19
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 95 6e-19
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 93 2e-18
gi|104526627 triadin [Homo sapiens] 93 2e-18
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 93 2e-18
gi|42560244 peptidylprolyl isomerase G [Homo sapiens] 91 1e-17
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 89 4e-17
gi|154146223 splicing factor, arginine/serine-rich 130 [Homo sap... 89 4e-17
gi|154146193 splicing factor, arginine/serine-rich 130 [Homo sap... 89 4e-17
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 88 8e-17
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens] 84 1e-15
gi|151301171 RNA polymerase II transcription factor TAFII140 [Ho... 84 1e-15
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 82 5e-15
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1... 82 5e-15
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 80 1e-14
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 80 1e-14
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 80 1e-14
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 80 1e-14
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 80 2e-14
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ... 78 6e-14
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 78 8e-14
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 77 1e-13
gi|156104889 myeloid/lymphoid or mixed-lineage leukemia (trithor... 77 1e-13
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 75 7e-13
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 73 2e-12
gi|122937227 U2-associated SR140 protein [Homo sapiens] 73 2e-12
>gi|125656165 THO complex 2 [Homo sapiens]
Length = 1593
Score = 3208 bits (8317), Expect = 0.0
Identities = 1593/1593 (100%), Positives = 1593/1593 (100%)
Query: 1 MAAAAVVVPAEWIKNWEKSGRGEFLHLCRILSENKSHDSSTYRDFQQALYELSYHVIKGN 60
MAAAAVVVPAEWIKNWEKSGRGEFLHLCRILSENKSHDSSTYRDFQQALYELSYHVIKGN
Sbjct: 1 MAAAAVVVPAEWIKNWEKSGRGEFLHLCRILSENKSHDSSTYRDFQQALYELSYHVIKGN 60
Query: 61 LKHEQASNVLSDISEFREDMPSILADVFCILDIETNCLEEKSKRDYFTQLVLACLYLVSD 120
LKHEQASNVLSDISEFREDMPSILADVFCILDIETNCLEEKSKRDYFTQLVLACLYLVSD
Sbjct: 61 LKHEQASNVLSDISEFREDMPSILADVFCILDIETNCLEEKSKRDYFTQLVLACLYLVSD 120
Query: 121 TVLKERLDPETLESLGLIKQSQQFNQKSVKIKTKLFYKQQKFNLLREENEGYAKLIAELG 180
TVLKERLDPETLESLGLIKQSQQFNQKSVKIKTKLFYKQQKFNLLREENEGYAKLIAELG
Sbjct: 121 TVLKERLDPETLESLGLIKQSQQFNQKSVKIKTKLFYKQQKFNLLREENEGYAKLIAELG 180
Query: 181 QDLSGSITSDLILENIKSLIGCFNLDPNRVLDVILEVFECRPEHDDFFISLLESYMSMCE 240
QDLSGSITSDLILENIKSLIGCFNLDPNRVLDVILEVFECRPEHDDFFISLLESYMSMCE
Sbjct: 181 QDLSGSITSDLILENIKSLIGCFNLDPNRVLDVILEVFECRPEHDDFFISLLESYMSMCE 240
Query: 241 PQTLCHILGFKFKFYQEPNGETPSSLYRVAAVLLQFNLIDLDDLYVHLLPADNCIMDEHK 300
PQTLCHILGFKFKFYQEPNGETPSSLYRVAAVLLQFNLIDLDDLYVHLLPADNCIMDEHK
Sbjct: 241 PQTLCHILGFKFKFYQEPNGETPSSLYRVAAVLLQFNLIDLDDLYVHLLPADNCIMDEHK 300
Query: 301 REIAEAKQIVRKLTMVVLSSEKMDEREKEKEKEEEKVEKPPDNQKLGLLEALLKIGDWQH 360
REIAEAKQIVRKLTMVVLSSEKMDEREKEKEKEEEKVEKPPDNQKLGLLEALLKIGDWQH
Sbjct: 301 REIAEAKQIVRKLTMVVLSSEKMDEREKEKEKEEEKVEKPPDNQKLGLLEALLKIGDWQH 360
Query: 361 AQNIMDQMPPYYAASHKLIALAICKLIHITIEPLYRRVGVPKGAKGSPVNALQNKRAPKQ 420
AQNIMDQMPPYYAASHKLIALAICKLIHITIEPLYRRVGVPKGAKGSPVNALQNKRAPKQ
Sbjct: 361 AQNIMDQMPPYYAASHKLIALAICKLIHITIEPLYRRVGVPKGAKGSPVNALQNKRAPKQ 420
Query: 421 AESFEDLRRDVFNMFCYLGPHLSHDPILFAKVVRIGKSFMKEFQSDGSKQEDKEKTEVIL 480
AESFEDLRRDVFNMFCYLGPHLSHDPILFAKVVRIGKSFMKEFQSDGSKQEDKEKTEVIL
Sbjct: 421 AESFEDLRRDVFNMFCYLGPHLSHDPILFAKVVRIGKSFMKEFQSDGSKQEDKEKTEVIL 480
Query: 481 SCLLSITDQVLLPSLSLMDCNACMSEELWGMFKTFPYQHRYRLYGQWKNETYNSHPLLVK 540
SCLLSITDQVLLPSLSLMDCNACMSEELWGMFKTFPYQHRYRLYGQWKNETYNSHPLLVK
Sbjct: 481 SCLLSITDQVLLPSLSLMDCNACMSEELWGMFKTFPYQHRYRLYGQWKNETYNSHPLLVK 540
Query: 541 VKAQTIDRAKYIMKRLTKENVKPSGRQIGKLSHSNPTILFDYILSQIQKYDNLITPVVDS 600
VKAQTIDRAKYIMKRLTKENVKPSGRQIGKLSHSNPTILFDYILSQIQKYDNLITPVVDS
Sbjct: 541 VKAQTIDRAKYIMKRLTKENVKPSGRQIGKLSHSNPTILFDYILSQIQKYDNLITPVVDS 600
Query: 601 LKYLTSLNYDVLAYCIIEALANPEKERMKHDDTTISSWLQSLASFCGAVFRKYPIDLAGL 660
LKYLTSLNYDVLAYCIIEALANPEKERMKHDDTTISSWLQSLASFCGAVFRKYPIDLAGL
Sbjct: 601 LKYLTSLNYDVLAYCIIEALANPEKERMKHDDTTISSWLQSLASFCGAVFRKYPIDLAGL 660
Query: 661 LQYVANQLKAGKSFDLLILKEVVQKMAGIEITEEMTMEQLEAMTGGEQLKAEGGYFGQIR 720
LQYVANQLKAGKSFDLLILKEVVQKMAGIEITEEMTMEQLEAMTGGEQLKAEGGYFGQIR
Sbjct: 661 LQYVANQLKAGKSFDLLILKEVVQKMAGIEITEEMTMEQLEAMTGGEQLKAEGGYFGQIR 720
Query: 721 NTKKSSQRLKDALLDHDLALPLCLLMAQQRNGVIFQEGGEKHLKLVGKLYDQCHDTLVQF 780
NTKKSSQRLKDALLDHDLALPLCLLMAQQRNGVIFQEGGEKHLKLVGKLYDQCHDTLVQF
Sbjct: 721 NTKKSSQRLKDALLDHDLALPLCLLMAQQRNGVIFQEGGEKHLKLVGKLYDQCHDTLVQF 780
Query: 781 GGFLASNLSTEDYIKRVPSIDVLCNEFHTPHDAAFFLSRPMYAHHISSKYDELKKSEKGS 840
GGFLASNLSTEDYIKRVPSIDVLCNEFHTPHDAAFFLSRPMYAHHISSKYDELKKSEKGS
Sbjct: 781 GGFLASNLSTEDYIKRVPSIDVLCNEFHTPHDAAFFLSRPMYAHHISSKYDELKKSEKGS 840
Query: 841 KQQHKVHKYITSCEMVMAPVHEAVVSLHVSKVWDDISPQFYATFWSLTMYDLAVPHTSYE 900
KQQHKVHKYITSCEMVMAPVHEAVVSLHVSKVWDDISPQFYATFWSLTMYDLAVPHTSYE
Sbjct: 841 KQQHKVHKYITSCEMVMAPVHEAVVSLHVSKVWDDISPQFYATFWSLTMYDLAVPHTSYE 900
Query: 901 REVNKLKVQMKAIDDNQEMPPNKKKKEKERCTALQDKLLEEEKKQMEHVQRVLQRLKLEK 960
REVNKLKVQMKAIDDNQEMPPNKKKKEKERCTALQDKLLEEEKKQMEHVQRVLQRLKLEK
Sbjct: 901 REVNKLKVQMKAIDDNQEMPPNKKKKEKERCTALQDKLLEEEKKQMEHVQRVLQRLKLEK 960
Query: 961 DNWLLAKSTKNETITKFLQLCIFPRCIFSAIDAVYCARFVELVHQQKTPNFSTLLCYDRV 1020
DNWLLAKSTKNETITKFLQLCIFPRCIFSAIDAVYCARFVELVHQQKTPNFSTLLCYDRV
Sbjct: 961 DNWLLAKSTKNETITKFLQLCIFPRCIFSAIDAVYCARFVELVHQQKTPNFSTLLCYDRV 1020
Query: 1021 FSDIIYTVASCTENEASRYGRFLCCMLETVTRWHSDRATYEKECGNYPGFLTILRATGFD 1080
FSDIIYTVASCTENEASRYGRFLCCMLETVTRWHSDRATYEKECGNYPGFLTILRATGFD
Sbjct: 1021 FSDIIYTVASCTENEASRYGRFLCCMLETVTRWHSDRATYEKECGNYPGFLTILRATGFD 1080
Query: 1081 GGNKADQLDYENFRHVVHKWHYKLTKASVHCLETGEYTHIRNILIVLTKILPWYPKVLNL 1140
GGNKADQLDYENFRHVVHKWHYKLTKASVHCLETGEYTHIRNILIVLTKILPWYPKVLNL
Sbjct: 1081 GGNKADQLDYENFRHVVHKWHYKLTKASVHCLETGEYTHIRNILIVLTKILPWYPKVLNL 1140
Query: 1141 GQALERRVHKICQEEKEKRPDLYALAMGYSGQLKSRKSYMIPENEFHHKDPPPRNAVASV 1200
GQALERRVHKICQEEKEKRPDLYALAMGYSGQLKSRKSYMIPENEFHHKDPPPRNAVASV
Sbjct: 1141 GQALERRVHKICQEEKEKRPDLYALAMGYSGQLKSRKSYMIPENEFHHKDPPPRNAVASV 1200
Query: 1201 QNGPGGGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGS 1260
QNGPGGGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGS
Sbjct: 1201 QNGPGGGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGS 1260
Query: 1261 NSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKER 1320
NSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKER
Sbjct: 1261 NSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKER 1320
Query: 1321 TPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVK 1380
TPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVK
Sbjct: 1321 TPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVK 1380
Query: 1381 GGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYI 1440
GGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYI
Sbjct: 1381 GGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYI 1440
Query: 1441 NHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRR 1500
NHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRR
Sbjct: 1441 NHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRR 1500
Query: 1501 KEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKE 1560
KEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKE
Sbjct: 1501 KEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKE 1560
Query: 1561 SRHDKEKIEKKEKRDSSGGKEEKKHHKSSDKHR 1593
SRHDKEKIEKKEKRDSSGGKEEKKHHKSSDKHR
Sbjct: 1561 SRHDKEKIEKKEKRDSSGGKEEKKHHKSSDKHR 1593
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 [Homo
sapiens]
Length = 916
Score = 100 bits (250), Expect = 9e-21
Identities = 97/367 (26%), Positives = 157/367 (42%), Gaps = 70/367 (19%)
Query: 1265 AVKENDKEKGKEKEKE----------KKEKTPATTPEARVL-GKDGKEKPKEERPNKDEK 1313
++KE KE +EKE+E KK AT PE + G+ +E+ +EE +DE
Sbjct: 483 SMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEG 542
Query: 1314 ARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEM 1373
A+ ++ + EKE ++E+ + E+ +T E+++ E KE + + ++E+
Sbjct: 543 AKS--DQAEEGGSEKEGSSEKEEGEQEEGET-----EAEAEGEEAEAKEEKKVEEKSEEV 595
Query: 1374 KSKENVKGGEKTPVSGSLKSPVPRSDIPE---------PEREQKRRKIDTHP-SPSHSST 1423
+KE + K KSPVP+S + E P E+ + + P S
Sbjct: 596 ATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSP 655
Query: 1424 VKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKR 1483
V S +E K S P+SKS E K + KS E + K E + E+K
Sbjct: 656 VPKSPVEEKGKS----------PVSKSPVEEKAKSPVPKS--PVEEAKSKAEVGKGEQKE 703
Query: 1484 DHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCE------------------------ 1519
+ +E P + +KEE K K+ESP +
Sbjct: 704 EEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKE 763
Query: 1520 --SPYPNEKDKEKNKSKSSGKEKGSD-SFKSEKMDKISSGGKKESRHDKEKIEKKEKRDS 1576
P EK+KEK + +E+GSD K + + I+ G+ E KE++E++ K
Sbjct: 764 EGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEG---KEEVEQETKEKG 820
Query: 1577 SGGKEEK 1583
SG +EEK
Sbjct: 821 SGREEEK 827
Score = 67.4 bits (163), Expect = 1e-10
Identities = 75/303 (24%), Positives = 116/303 (38%), Gaps = 25/303 (8%)
Query: 1301 EKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQERERE 1360
+KPK E P + + +E ++ E EK + EE + V E K E+E
Sbjct: 437 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 496
Query: 1361 KEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSH 1420
+EP E E +K+PV + +P + + E E E+ + + + +
Sbjct: 497 EEPEAE----------EEEVAAKKSPVKAT--APEVKEEEGEKEEEEGQEEEEEEDEGAK 544
Query: 1421 SSTVKDSLIELKESSAKLYINHTPPPLSKSKE-REMDKKDLDKSRERSREREKKDE--KD 1477
S ++ E + SS K E E + K+ K E+S E K+E D
Sbjct: 545 SDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVAD 604
Query: 1478 RKERKRDHSNNDREVPP-------DLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEK 1530
K K + + + P + K EE G V K E +SP P +EK
Sbjct: 605 AKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEK 664
Query: 1531 NK---SKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHK 1587
K SKS +EK +++ S + KE+ EK+ K K EKK K
Sbjct: 665 GKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEK 724
Query: 1588 SSD 1590
D
Sbjct: 725 PKD 727
Score = 55.5 bits (132), Expect = 4e-07
Identities = 75/338 (22%), Positives = 130/338 (38%), Gaps = 42/338 (12%)
Query: 1207 GPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAV 1266
G S E S+E+ + +E + +A + + + + + + +
Sbjct: 542 GAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEEL 601
Query: 1267 KENDKEKGKEKEKEKKEKTPATTPEARVLGKDG-KEKPKEERPNK--DEKARETKERTPK 1323
+ K + EK K K+P + K +EK K P +EK + ++P
Sbjct: 602 VADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPV 661
Query: 1324 SDKEKEKFKK---EEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVK 1380
+K K K EEKAK K+ V A+SK+ + +KE E KE +E V+
Sbjct: 662 EEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKE--EEEKEVKEAPKEEKVE 719
Query: 1381 GGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYI 1440
E+ P D+PE ++ + SP V + + K S K+++
Sbjct: 720 KKEEKP-----------KDVPEKKKAE---------SPVKEEAVAEVVTITK--SVKVHL 757
Query: 1441 NHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNN-----DREVPPD 1495
K ++E +K+ E E E D+ + RK D + N EV +
Sbjct: 758 EKETKEEGKPLQQEKEKE--KAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQE 815
Query: 1496 LTKR---RKEENGTMGVSKHKSESPCESPYPNEKDKEK 1530
++ R+EE G V+ SP + +K +EK
Sbjct: 816 TKEKGSGREEEKGV--VTNGLDLSPADEKKGGDKSEEK 851
Score = 45.8 bits (107), Expect = 3e-04
Identities = 59/304 (19%), Positives = 131/304 (43%), Gaps = 34/304 (11%)
Query: 1312 EKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAK 1371
E A + KE + +E +++++ ++K + ++ ES Q + E+ + + +
Sbjct: 301 EAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQ 360
Query: 1372 E-MKSKENVKGGEKTPVSGSLKSPVPRSDIP---EPEREQKRRKIDTHPSPSHSSTVKDS 1427
+ ++ EN G K ++ L+ ++ + E R+ ++ + ST S
Sbjct: 361 DTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEET--RFSTFAGS 418
Query: 1428 LIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSR-------EREKKDEKDRKE 1480
+ + LY + PP++ S + + K + K + + + E + +DEK E
Sbjct: 419 I------TGPLYTHR--PPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEME 470
Query: 1481 RKRDHSNND-----REVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKS 1535
+ +E + + ++EE +SP ++ P K++E K +
Sbjct: 471 EALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEE 530
Query: 1536 SGKEKGSDSFKSEKMDKISSGG-KKESRHDKEKIEKKE-------KRDSSGGKEEKKHHK 1587
G+E+ + + K D+ GG +KE +KE+ E++E + + + KEEKK +
Sbjct: 531 EGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEE 590
Query: 1588 SSDK 1591
S++
Sbjct: 591 KSEE 594
Score = 45.8 bits (107), Expect = 3e-04
Identities = 63/306 (20%), Positives = 118/306 (38%), Gaps = 23/306 (7%)
Query: 1218 KSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEK 1277
K +E S E K + V+ KA S PK V+E K +
Sbjct: 587 KVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 646
Query: 1278 EKEKKEKTPATTPEARVLGKDGKEK-PKEERPNKDEKARETKERTPKSDKEKEKFKKEEK 1336
E+K K+P GK K P EE+ +E K++ K + +KEE+
Sbjct: 647 PVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGE-QKEEE 705
Query: 1337 AKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKG---GEKTPVSGSLKS 1393
K+ K ++ +E + EK+ + +D+ ++ K++ VK E ++ S+K
Sbjct: 706 EKEVK----------EAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKV 755
Query: 1394 PVPRSDIPEP---EREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKS 1450
+ + E ++E+++ K + K + KE A +N +
Sbjct: 756 HLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIA---VNGEVEG-KEE 811
Query: 1451 KEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVS 1510
E+E +K + E+ D E+K + ++ V ++ E G G +
Sbjct: 812 VEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGD-GAT 870
Query: 1511 KHKSES 1516
K+ ++S
Sbjct: 871 KYITKS 876
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 [Homo
sapiens]
Length = 540
Score = 100 bits (250), Expect = 9e-21
Identities = 97/367 (26%), Positives = 157/367 (42%), Gaps = 70/367 (19%)
Query: 1265 AVKENDKEKGKEKEKE----------KKEKTPATTPEARVL-GKDGKEKPKEERPNKDEK 1313
++KE KE +EKE+E KK AT PE + G+ +E+ +EE +DE
Sbjct: 107 SMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEG 166
Query: 1314 ARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEM 1373
A+ ++ + EKE ++E+ + E+ +T E+++ E KE + + ++E+
Sbjct: 167 AKS--DQAEEGGSEKEGSSEKEEGEQEEGET-----EAEAEGEEAEAKEEKKVEEKSEEV 219
Query: 1374 KSKENVKGGEKTPVSGSLKSPVPRSDIPE---------PEREQKRRKIDTHP-SPSHSST 1423
+KE + K KSPVP+S + E P E+ + + P S
Sbjct: 220 ATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSP 279
Query: 1424 VKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKR 1483
V S +E K S P+SKS E K + KS E + K E + E+K
Sbjct: 280 VPKSPVEEKGKS----------PVSKSPVEEKAKSPVPKS--PVEEAKSKAEVGKGEQKE 327
Query: 1484 DHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCE------------------------ 1519
+ +E P + +KEE K K+ESP +
Sbjct: 328 EEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKE 387
Query: 1520 --SPYPNEKDKEKNKSKSSGKEKGSD-SFKSEKMDKISSGGKKESRHDKEKIEKKEKRDS 1576
P EK+KEK + +E+GSD K + + I+ G+ E KE++E++ K
Sbjct: 388 EGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEG---KEEVEQETKEKG 444
Query: 1577 SGGKEEK 1583
SG +EEK
Sbjct: 445 SGREEEK 451
Score = 67.4 bits (163), Expect = 1e-10
Identities = 75/303 (24%), Positives = 116/303 (38%), Gaps = 25/303 (8%)
Query: 1301 EKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQERERE 1360
+KPK E P + + +E ++ E EK + EE + V E K E+E
Sbjct: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 120
Query: 1361 KEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSH 1420
+EP E E +K+PV + +P + + E E E+ + + + +
Sbjct: 121 EEPEAE----------EEEVAAKKSPVKAT--APEVKEEEGEKEEEEGQEEEEEEDEGAK 168
Query: 1421 SSTVKDSLIELKESSAKLYINHTPPPLSKSKE-REMDKKDLDKSRERSREREKKDE--KD 1477
S ++ E + SS K E E + K+ K E+S E K+E D
Sbjct: 169 SDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVAD 228
Query: 1478 RKERKRDHSNNDREVPP-------DLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEK 1530
K K + + + P + K EE G V K E +SP P +EK
Sbjct: 229 AKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEK 288
Query: 1531 NK---SKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHK 1587
K SKS +EK +++ S + KE+ EK+ K K EKK K
Sbjct: 289 GKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEK 348
Query: 1588 SSD 1590
D
Sbjct: 349 PKD 351
Score = 55.5 bits (132), Expect = 4e-07
Identities = 75/338 (22%), Positives = 130/338 (38%), Gaps = 42/338 (12%)
Query: 1207 GPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAV 1266
G S E S+E+ + +E + +A + + + + + + +
Sbjct: 166 GAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEEL 225
Query: 1267 KENDKEKGKEKEKEKKEKTPATTPEARVLGKDG-KEKPKEERPNK--DEKARETKERTPK 1323
+ K + EK K K+P + K +EK K P +EK + ++P
Sbjct: 226 VADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPV 285
Query: 1324 SDKEKEKFKK---EEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVK 1380
+K K K EEKAK K+ V A+SK+ + +KE E KE +E V+
Sbjct: 286 EEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKE--EEEKEVKEAPKEEKVE 343
Query: 1381 GGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYI 1440
E+ P D+PE ++ + SP V + + K S K+++
Sbjct: 344 KKEEKP-----------KDVPEKKKAE---------SPVKEEAVAEVVTITK--SVKVHL 381
Query: 1441 NHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNN-----DREVPPD 1495
K ++E +K+ E E E D+ + RK D + N EV +
Sbjct: 382 EKETKEEGKPLQQEKEKE--KAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQE 439
Query: 1496 LTKR---RKEENGTMGVSKHKSESPCESPYPNEKDKEK 1530
++ R+EE G V+ SP + +K +EK
Sbjct: 440 TKEKGSGREEEKGV--VTNGLDLSPADEKKGGDKSEEK 475
Score = 45.8 bits (107), Expect = 3e-04
Identities = 63/306 (20%), Positives = 118/306 (38%), Gaps = 23/306 (7%)
Query: 1218 KSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEK 1277
K +E S E K + V+ KA S PK V+E K +
Sbjct: 211 KVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 270
Query: 1278 EKEKKEKTPATTPEARVLGKDGKEK-PKEERPNKDEKARETKERTPKSDKEKEKFKKEEK 1336
E+K K+P GK K P EE+ +E K++ K + +KEE+
Sbjct: 271 PVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGE-QKEEE 329
Query: 1337 AKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKG---GEKTPVSGSLKS 1393
K+ K ++ +E + EK+ + +D+ ++ K++ VK E ++ S+K
Sbjct: 330 EKEVK----------EAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKV 379
Query: 1394 PVPRSDIPEP---EREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKS 1450
+ + E ++E+++ K + K + KE A +N +
Sbjct: 380 HLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIA---VNGEVEG-KEE 435
Query: 1451 KEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVS 1510
E+E +K + E+ D E+K + ++ V ++ E G G +
Sbjct: 436 VEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGD-GAT 494
Query: 1511 KHKSES 1516
K+ ++S
Sbjct: 495 KYITKS 500
Score = 45.1 bits (105), Expect = 6e-04
Identities = 37/167 (22%), Positives = 75/167 (44%), Gaps = 20/167 (11%)
Query: 1445 PPLSKSKEREMDKKDLDKSRERSR-------EREKKDEKDRKERKRDHSNND-----REV 1492
PP++ S + + K + K + + + E + +DEK E + +E
Sbjct: 52 PPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEE 111
Query: 1493 PPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDK 1552
+ + ++EE +SP ++ P K++E K + G+E+ + + K D+
Sbjct: 112 KKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQ 171
Query: 1553 ISSGG-KKESRHDKEKIEKKE-------KRDSSGGKEEKKHHKSSDK 1591
GG +KE +KE+ E++E + + + KEEKK + S++
Sbjct: 172 AEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEE 218
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 99.8 bits (247), Expect = 2e-20
Identities = 104/405 (25%), Positives = 173/405 (42%), Gaps = 39/405 (9%)
Query: 1172 QLKSRKSYMIPENEFHHKDPPPRNAVASVQNGPGGGPSSSSIGSASKSDE---SSTEETD 1228
+ KS + PE E ++ V + P + S + + +KS E S +E
Sbjct: 645 EAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPE--KAKSPVKAEAKSPEKAKSPVKEEA 702
Query: 1229 KSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPAT 1288
KS E+++ VK K+ + + VKE K K K EK +
Sbjct: 703 KSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVK 762
Query: 1289 TPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKE--KEKFKKEEKAKDEKFKTTV 1346
+PEA+ K+ P ++ P K + + + ++P+ K KE K EK +K +
Sbjct: 763 SPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKS 822
Query: 1347 PNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPERE 1406
P E + QE + KEP ++ A+E K+ K EK S K P+ + P+P+ E
Sbjct: 823 PVKEEEKPQE-VKVKEPPKK---AEEEKAPATPKTEEK---KDSKKEEAPKKEAPKPKVE 875
Query: 1407 QKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRER 1466
+K+ P K+S +E K+ A+ P K +++ K+ K +E+
Sbjct: 876 EKKEPAVEKP--------KESKVEAKKEEAE--DKKKVPTPEKEAPAKVEVKEDAKPKEK 925
Query: 1467 SREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEK 1526
+ E KK+ D K ++ +E P+ K KEE K++ P E P K
Sbjct: 926 T-EVAKKEPDDAKAKEPSKPAEKKEAAPE-KKDTKEE---------KAKKPEEKPKTEAK 974
Query: 1527 DKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKK 1571
KE +K+ S K K+EK +K SS +K+S+ ++ E K
Sbjct: 975 AKEDDKTLSKEPSKP----KAEKAEKSSSTDQKDSKPPEKATEDK 1015
Score = 90.5 bits (223), Expect = 1e-17
Identities = 98/403 (24%), Positives = 167/403 (41%), Gaps = 38/403 (9%)
Query: 1209 SSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKE 1268
S + + S K+ +S T+E KS E++ K+ K + +P+ S + + S + K
Sbjct: 628 SPAEVKSPEKA-KSPTKEEAKSPEKA----KSPEKEEAKSPEKAKSPVKAEAKSPEKAKS 682
Query: 1269 NDKEKGKEKEKEKKE-KTPATTPEARV--LGKDGKEKPKEERPNKDEKARETKERTPKSD 1325
K + K EK K K A +PE + ++ K K + P K+E K ++P +
Sbjct: 683 PVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKE 742
Query: 1326 KEK--EKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERD-IAKEMKS------- 1375
+ K EK K EKAK K+ +K +K P + + + +E+KS
Sbjct: 743 EAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSP 802
Query: 1376 -KENVKGGEKT-PVSGSLKSPVPRSDIP------EPEREQKRRKIDTHPSPSHSSTVKDS 1427
KE+ K EK P +KSPV + P EP ++ + K P K
Sbjct: 803 LKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKE 862
Query: 1428 LIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSN 1487
KE+ P + K KE +++ K + ++ +K+ + E K D
Sbjct: 863 EAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAK- 921
Query: 1488 NDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKS 1547
P + T+ K+E + + + P +KD ++ K+K +EK K+
Sbjct: 922 -----PKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKP-EEKPKTEAKA 975
Query: 1548 EKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSD 1590
++ DK S K K EK EK S+ K+ K K+++
Sbjct: 976 KEDDKTLS-----KEPSKPKAEKAEKSSSTDQKDSKPPEKATE 1013
Score = 84.7 bits (208), Expect = 6e-16
Identities = 96/443 (21%), Positives = 172/443 (38%), Gaps = 44/443 (9%)
Query: 1172 QLKSRKSYMIPENEFHHKDPPPRNAVASVQNGPGGGPSSSSIGSASKSDESSTEETD--- 1228
++KS + P E P ++ P S S +K + S E
Sbjct: 543 EVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPE 602
Query: 1229 ------KSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKK 1282
K +S K+ K + +P S + S + + K +K K EKE+ K
Sbjct: 603 KAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKS 662
Query: 1283 EKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKF 1342
+ + +A + + P + EKA+ + KS ++ + KEE EK
Sbjct: 663 PEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKA 722
Query: 1343 KTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPE 1402
K+ V + + E+ K P +E E KS E K EK +KSP ++
Sbjct: 723 KSPV----KEEAKTPEKAKSPVKE-----EAKSPEKAKSPEKAKTL-DVKSPEAKT---- 768
Query: 1403 PEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPP--PLSKSKEREMDKKDL 1460
P +E+ R D P + S VK+ + +++ + L + P + K +E + K+
Sbjct: 769 PAKEEARSPADKFPEKA-KSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEE 827
Query: 1461 DKSRE-------RSREREKKDEKDRKERKRDHSNND---REVPPDLTKRRKE------EN 1504
+K +E + E EK + E K+D + +E P + +KE +
Sbjct: 828 EKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKE 887
Query: 1505 GTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHD 1564
+ K ++E + P P ++ K + K K K ++ D + K+ S+
Sbjct: 888 SKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPD--DAKAKEPSKPA 945
Query: 1565 KEKIEKKEKRDSSGGKEEKKHHK 1587
++K EK+D+ K +K K
Sbjct: 946 EKKEAAPEKKDTKEEKAKKPEEK 968
Score = 84.0 bits (206), Expect = 1e-15
Identities = 108/440 (24%), Positives = 176/440 (40%), Gaps = 53/440 (12%)
Query: 1189 KDPPPRNAVASVQNGPGGGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTT 1248
K PP A + + + + +KS E E + +S K+ K + +
Sbjct: 502 KSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKE-EAKSPAEVKSPEKAKSPAKEEAKS 560
Query: 1249 PKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEER- 1307
P S + S VK +K K KE+ K + +A+ K+ + P E +
Sbjct: 561 PPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKS 620
Query: 1308 PNKDEKARETKERTPKSDKE--KEKFKKEEKAKD---------EKFKTTVPNAESKSTQE 1356
P K+E + ++P+ K KE+ K EKAK EK K+ V AE+KS ++
Sbjct: 621 PVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPV-KAEAKSPEK 679
Query: 1357 -----REREKEPSRERDIAKE-----MKSKENVKGGEKTPVSGSLKSPVPRSDIPEPERE 1406
+ K P + + KE K+K VK K+P KSPV + + PE+
Sbjct: 680 AKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKA--KSPV-KEEAKTPEKA 736
Query: 1407 QKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRER 1466
+ K + S K +++K AK TP +K + R K +K++
Sbjct: 737 KSPVKEEAKSPEKAKSPEKAKTLDVKSPEAK-----TP---AKEEARSPADKFPEKAKSP 788
Query: 1467 SREREKKDEKDRKERKRDHSNNDREVP--PDLTKRRKEENGTMGV------SKHKSESPC 1518
+E K EK + K D ++E+P ++ KEE V K + E
Sbjct: 789 VKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAP 848
Query: 1519 ESPYPNEKDKEKNKS-------KSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKK 1571
+P EK K + K +EK + + K K+ + KKE DK+K+
Sbjct: 849 ATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEA--KKEEAEDKKKVPTP 906
Query: 1572 EKRDSSGGKEEKKHHKSSDK 1591
EK ++ E K+ K +K
Sbjct: 907 EK-EAPAKVEVKEDAKPKEK 925
Score = 82.4 bits (202), Expect = 3e-15
Identities = 97/400 (24%), Positives = 165/400 (41%), Gaps = 39/400 (9%)
Query: 1206 GGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKA 1265
GG + G ++ EE + ++ VK K+ P S + S
Sbjct: 488 GGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKS----PAEAKSPEKEEAKSPAE 543
Query: 1266 VKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKE-ERPNKDEKARETKERTPKS 1324
VK +K K KE+ K + PEA+ K+ + P E + P K + + + ++P
Sbjct: 544 VKSPEKAKSPAKEEAK------SPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAE 597
Query: 1325 DKEKEKFKK--EEKAKDEKFKTTVPNAESKSTQE---REREKEPSRERDIAKEMKSKENV 1379
K EK K +E+AK + E+KS E E+ K P++E E KS E
Sbjct: 598 AKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKE-----EAKSPEKA 652
Query: 1380 KGGEKTPVSG--SLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAK 1437
K EK KSPV +++ PE+ + K + S VK+ +++ +
Sbjct: 653 KSPEKEEAKSPEKAKSPV-KAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSP 711
Query: 1438 LYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLT 1497
+ P +KS +E + K +K++ +E K EK + K D + P T
Sbjct: 712 VKEEAKSPEKAKSPVKE-EAKTPEKAKSPVKEEAKSPEKAKSPEKA--KTLDVKSPEAKT 768
Query: 1498 KRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKS-EKMDKISSG 1556
++E K++SP + E+ K K+KS KE K K +++ S
Sbjct: 769 PAKEEARSPADKFPEKAKSPVK-----EEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSP 823
Query: 1557 GKKESRHDKEKIE------KKEKRDSSGGKEEKKHHKSSD 1590
K+E + + K++ ++EK ++ EEKK K +
Sbjct: 824 VKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEE 863
Score = 73.9 bits (180), Expect = 1e-12
Identities = 88/394 (22%), Positives = 155/394 (39%), Gaps = 53/394 (13%)
Query: 1221 ESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKE 1280
E TEET + E ++ K + +G G ++ EKE +
Sbjct: 458 EEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAK 517
Query: 1281 KKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKF--------- 1331
K A +P + K KEE + E K ++P KE+ K
Sbjct: 518 SPVKEEAKSPA------EAKSPEKEEAKSPAEVKSPEKAKSPA--KEEAKSPPEAKSPEK 569
Query: 1332 ---------KKEEKAKDEKFKTTVPNAESKSTQE-----REREKEPSRERD-IAKEMKSK 1376
K EKAK + AE+KS ++ +E K P+ + + +E KS
Sbjct: 570 EEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSP 629
Query: 1377 ENVKGGE--KTPVSGSLKSP-----VPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLI 1429
VK E K+P KSP + + PE+ + K + S VK
Sbjct: 630 AEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAK 689
Query: 1430 ELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNND 1489
+++ + + P +KS +E + K +K++ +E K EK + K + + +
Sbjct: 690 SPEKAKSPVKEEAKSPEKAKSPVKE-EAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPE 748
Query: 1490 REVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEK 1549
+ P+ K T+ V ++++P + + DK K+KS KE + +
Sbjct: 749 KAKSPEKAK-------TLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKE------EVKS 795
Query: 1550 MDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEK 1583
+K S K++++ +++I KKE+ S +EEK
Sbjct: 796 PEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEK 829
Score = 73.2 bits (178), Expect = 2e-12
Identities = 84/347 (24%), Positives = 142/347 (40%), Gaps = 37/347 (10%)
Query: 1266 VKENDKEKGKEKEK-------EKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETK 1318
VK +K K EK + E+ E+T T K+ KE+ +E +E+ E
Sbjct: 438 VKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGG 497
Query: 1319 ERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQERERE-----KEPSRERDIAKE- 1372
E KS +E E++AK + AE+KS ++ E + K P + + AKE
Sbjct: 498 EEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEE 557
Query: 1373 MKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELK 1432
KS K EK KSP +++ PE+ + K + SP+ + + + + +K
Sbjct: 558 AKSPPEAKSPEKE----EAKSP---AEVKSPEKAKSPAK-EEAKSPAEAKSPEKAKSPVK 609
Query: 1433 ESS-------------AKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRK 1479
E + AK P +KS +E + K +K++ +E K EK +
Sbjct: 610 EEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKE-EAKSPEKAKSPEKEEAKSPEKAKS 668
Query: 1480 ERKRDHSNNDREVPPDLTKRRKEENGTMGVSKH-KSESPCESPYPNE-KDKEKNKSKSSG 1537
K + + ++ P + + E V + KS +SP E K EK KS
Sbjct: 669 PVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKE 728
Query: 1538 KEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKK 1584
+ K + KS ++ S K +S + ++ K + KEE +
Sbjct: 729 EAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEAR 775
Score = 69.3 bits (168), Expect = 3e-11
Identities = 79/340 (23%), Positives = 136/340 (40%), Gaps = 32/340 (9%)
Query: 1266 VKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSD 1325
+K +EK K EK +KE E+ EE +E E ++ + +
Sbjct: 436 IKVKSEEKIKVVEKSEKETVIV-------------EEQTEETQVTEEVTEEEEKEAKEEE 482
Query: 1326 KEKEKFKKEEKAKDEKFKTTVPNAESKSTQERERE-------KEPSRERDIAK-EMKSKE 1377
++E+ +EE+A+ + +T P AE ++ E+E + K P+ + K E KS
Sbjct: 483 GKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPA 542
Query: 1378 NVKGGE--KTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESS 1435
VK E K+P KSP + PE+E+ + + S K+ E K +
Sbjct: 543 EVKSPEKAKSPAKEEAKSP---PEAKSPEKEEAKSPAEVKSPEKAKSPAKE---EAKSPA 596
Query: 1436 AKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPD 1495
P+ + + + K K +S K EK + K + + ++ P+
Sbjct: 597 EAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPE 656
Query: 1496 LTKRRKEENGTMGV-SKHKSESPCESPYPNE-KDKEKNKSKSSGKEKGSDSFKSEKMDKI 1553
+ + E V ++ KS +SP E K EK KS + K + KS ++
Sbjct: 657 KEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEA 716
Query: 1554 SSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDKHR 1593
S K +S KE+ + EK S +E K K+ +
Sbjct: 717 KSPEKAKS-PVKEEAKTPEKAKSPVKEEAKSPEKAKSPEK 755
Score = 62.8 bits (151), Expect = 3e-09
Identities = 73/309 (23%), Positives = 130/309 (42%), Gaps = 35/309 (11%)
Query: 1305 EERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPS 1364
E P + K ++ + K EK +KE +E+ + T E +E+E ++E
Sbjct: 424 EGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEG 483
Query: 1365 RERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTV 1424
+E + +E E +GGE+ KSP P + PE+E K + SP+ + +
Sbjct: 484 KEEEGGEE----EEAEGGEE-----ETKSP-PAEEAASPEKEAKSPVKEEAKSPAEAKSP 533
Query: 1425 K----DSLIELK---ESSAKLYINHTPPPLSKSKEREMDKKDLD-KSRERSREREKKDEK 1476
+ S E+K ++ + PP +KS E+E K + KS E+++ K++ K
Sbjct: 534 EKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAK 593
Query: 1477 DRKERK---------RDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNE-K 1526
E K ++ + + E + + K K KS + E+ P + K
Sbjct: 594 SPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAK 653
Query: 1527 DKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHD-------KEKIEKKEKRDSSGG 1579
EK ++KS K K +++ +K S K E++ KE+ + EK S
Sbjct: 654 SPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVK 713
Query: 1580 KEEKKHHKS 1588
+E K K+
Sbjct: 714 EEAKSPEKA 722
Score = 40.4 bits (93), Expect = 0.014
Identities = 28/88 (31%), Positives = 39/88 (44%), Gaps = 3/88 (3%)
Query: 1265 AVKENDKEKGKEKEK--EKKEKTPATTPEARVLGKDGKEKPKEE-RPNKDEKARETKERT 1321
A KE D K KE K EKKE P K +EKPK E + +D+K +
Sbjct: 929 AKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSK 988
Query: 1322 PKSDKEKEKFKKEEKAKDEKFKTTVPNA 1349
PK++K ++ ++K K T A
Sbjct: 989 PKAEKAEKSSSTDQKDSKPPEKATEDKA 1016
Score = 38.5 bits (88), Expect = 0.052
Identities = 29/115 (25%), Positives = 48/115 (41%), Gaps = 14/115 (12%)
Query: 1225 EETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEK 1284
+E K +E+++ K + A + P +K ++ + K+ KE+K K
Sbjct: 917 KEDAKPKEKTEVAKKEPDDAKAKEP-------------SKPAEKKEAAPEKKDTKEEKAK 963
Query: 1285 TPATTPEARVLGK-DGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAK 1338
P P+ K D K KE K EKA ++ K K EK +++ AK
Sbjct: 964 KPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAK 1018
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 97.4 bits (241), Expect = 1e-19
Identities = 75/398 (18%), Positives = 176/398 (44%), Gaps = 38/398 (9%)
Query: 1203 GPGGGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNS 1262
G P +G A K + E ++ +ER + K T + +
Sbjct: 32 GSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKR-----QTERETDRKRERRREKD 86
Query: 1263 NKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARET----- 1317
++ +E+ +++EKE++ +T R ++ +++ + E + E+ R+
Sbjct: 87 RHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQ 146
Query: 1318 KERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKE 1377
+ER + D EKE+ ++ ++ E+ + T N + + +E+ R++ RER KE K+++
Sbjct: 147 RERERQRDAEKERERQTDR---ERQRQTERNRQKEREREKNRQERRERERQREKENKTED 203
Query: 1378 --NVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESS 1435
+ +G E+ R E E E+KR+ + ++ E + +S
Sbjct: 204 RHSERGRERE-----------RERETETETERKRQTDRERDRQRKTEREREKQAERERAS 252
Query: 1436 AKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPD 1495
+ + ++R+ D++ ++ R+ R+R+++ E+DR+ ++ +RE +
Sbjct: 253 ERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERE 312
Query: 1496 LTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISS 1555
++R+ E + E E E+D+EK + + K K E+ +
Sbjct: 313 RNRKRERER--------ERERERERQRETERDREKERER---KRKRQTEMDRERNRQTGR 361
Query: 1556 GGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDKHR 1593
G++++ ++E+ E++ R S+ +EE++ + D+ +
Sbjct: 362 EGRRQAERERER-ERERDRQSAREREERERDRDRDRQK 398
Score = 87.8 bits (216), Expect = 8e-17
Identities = 75/376 (19%), Positives = 166/376 (44%), Gaps = 32/376 (8%)
Query: 1220 DESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEK 1279
+ + E D+ RE+ + K + + + G + ++ +KE+ ++ ++
Sbjct: 106 ERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDR 165
Query: 1280 EKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKD 1339
E++ +T + R K+ +E+ + ER EK +T++R + +E+E+ ++ E +
Sbjct: 166 ERQRQTERNRQKEREREKNRQERRERERQR--EKENKTEDRHSERGRERERERETETETE 223
Query: 1340 EKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSD 1399
K +T + T EREREK+ RER +E E K E+ R
Sbjct: 224 RKRQTDRERDRQRKT-EREREKQAERERASERET---ERDKERERE-----------RDR 268
Query: 1400 IPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDK-- 1457
+ +R QK R+ T T +D E K + + +ERE ++
Sbjct: 269 DRDRDRRQKERERQTDRKRQRR-TERDRETERKRERQRERERERERNRKRERERERERER 327
Query: 1458 ---KDLDKSRERSREREKK--DEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKH 1512
++ ++ RE+ RER++K E DR+ ++ R+ + + R+ + + ++
Sbjct: 328 ERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQS---ARE 384
Query: 1513 KSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESR-HDKEKIEKK 1571
+ E + +K++E+ K ++ ++ + + D+ S G++ R +K+K ++
Sbjct: 385 REERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRER 444
Query: 1572 EKR---DSSGGKEEKK 1584
++ D G++ K+
Sbjct: 445 DRERQTDRQAGRQRKR 460
Score = 84.3 bits (207), Expect = 8e-16
Identities = 68/327 (20%), Positives = 141/327 (43%), Gaps = 28/327 (8%)
Query: 1219 SDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKE 1278
+++ +TD+ R+R + + + NK ++ E+G+E+E
Sbjct: 155 AEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKT-EDRHSERGRERE 213
Query: 1279 KEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAK 1338
+E++ +T +D + K + ER + E+ R + ER + DKE+E+ + ++ +
Sbjct: 214 RERETETETERKRQTDRERDRQRKTEREREKQAERERAS-ERETERDKERERERDRDRDR 272
Query: 1339 DEKFKTTVPNAESKSTQ--EREREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVP 1396
D + K + K + ER+RE E RER +E + + N K + +
Sbjct: 273 DRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRE 332
Query: 1397 RSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMD 1456
E ERE+KR++ + T ++ + + + +ERE D
Sbjct: 333 TERDREKERERKRKRQTEMDRERNRQTGREGRRQAERE--------------RERERERD 378
Query: 1457 KKDLDK--SRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENG-TMGVSKHK 1513
++ + RER R+R+++ E++R+ K + E + K R+ E G G + K
Sbjct: 379 RQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREK 438
Query: 1514 SESPCESPYPNEKDKEKNKSKSSGKEK 1540
+ E+D+E+ + +G+++
Sbjct: 439 QKG-------RERDRERQTDRQAGRQR 458
Score = 59.7 bits (143), Expect = 2e-08
Identities = 43/213 (20%), Positives = 94/213 (44%), Gaps = 12/213 (5%)
Query: 1218 KSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEK 1277
++D T++ RE + + + + +E ++++ KE+
Sbjct: 282 QTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKER 341
Query: 1278 EKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEK------ARETKERTPKSDKEKEKF 1331
E+++K +T R G++G+ + + ER + E+ RE +ER D++KE+
Sbjct: 342 ERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERE 401
Query: 1332 KKEEKAKDEKFKTTVPNAESK---STQEREREKEPSRERDIAKEMKSKENVKGGEKTPVS 1388
++ EK +D + +T K S + RER +E +++ ++ + + + + G + S
Sbjct: 402 RQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRS 461
Query: 1389 GSLKSPVP---RSDIPEPEREQKRRKIDTHPSP 1418
+P P RS + + + + R I SP
Sbjct: 462 TLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSP 494
Score = 38.5 bits (88), Expect = 0.052
Identities = 25/141 (17%), Positives = 64/141 (45%), Gaps = 12/141 (8%)
Query: 1460 LDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCE 1519
LD SR R +E + + +D +DRE R+KE + + E+ +
Sbjct: 24 LDFSRRRPGSQESPRRRGLGQAHKDADGDDRE-----RNRQKERERRREKRQTERETDRK 78
Query: 1520 SPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGG 1579
EKD+ + + + +++ + + + D+ +++ R+ +++ E++ +R+ G
Sbjct: 79 RERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERG 138
Query: 1580 KE-------EKKHHKSSDKHR 1593
++ E++ + ++K R
Sbjct: 139 RDRQTDGQRERERQRDAEKER 159
>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
Length = 1007
Score = 94.7 bits (234), Expect = 6e-19
Identities = 104/425 (24%), Positives = 173/425 (40%), Gaps = 53/425 (12%)
Query: 1198 ASVQNGPGGGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGN 1257
A + N G S +G + ES +EE + E+++ G ++ ++SST KG +
Sbjct: 118 AELDNELMEGKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSST--KGKLELVD 175
Query: 1258 SGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARET 1317
+ + K K KE+ + + +KK K + + KE+ K + P+K K+++
Sbjct: 176 NKITTKKRSKSRSKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQ 235
Query: 1318 ------------------KERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQERER 1359
K R+P DK K + + K+KD K K+ + N ES+S ++
Sbjct: 236 ARKSKSPTLRRRSQEKIGKARSPTDDKVK--IEDKSKSKDRK-KSPIIN-ESRSRDRGKK 291
Query: 1360 EKEP-------SRERDIAKEMKSKENVKGGEKTPVSGSLKSPVP----RSDIPEPEREQK 1408
+ P R +KE KSK + EK P+ K RS P R K
Sbjct: 292 SRSPVDLRGKSKDRRSRSKERKSKRSETDKEKKPIKSPSKDASSGKENRSPSRRPGRSPK 351
Query: 1409 RRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRER-- 1466
RR + P S + L+ + S + T P ++K R +++K + R R
Sbjct: 352 RRSLSPKPR-DKSRRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLS 410
Query: 1467 -SREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNE 1525
R R + D R+ER +D S +R P T+RR S+ SP
Sbjct: 411 SPRTRPRDDILSRRERSKDASPINRWSP---TRRR---------SRSPIRRRSRSPLRRS 458
Query: 1526 KDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKH 1585
+ + +++G S + S GG++ K K +K + S G K E++
Sbjct: 459 RSPRRRSRSPRRRDRGRRSRSRLRRRSRSRGGRRRRSRSKVKEDKFKGSLSEGMKVEQE- 517
Query: 1586 HKSSD 1590
SSD
Sbjct: 518 -SSSD 521
Score = 63.9 bits (154), Expect = 1e-09
Identities = 88/390 (22%), Positives = 154/390 (39%), Gaps = 33/390 (8%)
Query: 1218 KSDESSTEETDKSRERSQCGVKAVNKA--SSTTPKGNSSNGNSGSNSNKAVKENDKEKGK 1275
K SS E+ DK + K K ++ +G S + + +++ +K++
Sbjct: 56 KHKHSSEEDKDKKHKHKHKHKKHKRKEIIDASDKEGMSPAKRTKLDDLALLEDLEKQRAL 115
Query: 1276 EKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEE 1335
K + E L G E EE EKAR + +S K K
Sbjct: 116 IKAELDNELMEGKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTKGKL---- 171
Query: 1336 KAKDEKFKTTVPNAESKS---TQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLK 1392
+ D K TT ++S+S T+ R +K+ +I KE ++ K +K+ K
Sbjct: 172 ELVDNKI-TTKKRSKSRSKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKS------K 224
Query: 1393 SPVPRSDIPEPEREQK----RRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLS 1448
SP RS + R+ K RR+ + S T D +++++ S K P ++
Sbjct: 225 SPSKRSKSQDQARKSKSPTLRRRSQEKIGKARSPT--DDKVKIEDKS-KSKDRKKSPIIN 281
Query: 1449 KSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMG 1508
+S+ R+ KK R + ++++ KERK S D+E P + + +G
Sbjct: 282 ESRSRDRGKKSRSPVDLRGKSKDRRSRS--KERKSKRSETDKEKKPIKSPSKDASSGK-- 337
Query: 1509 VSKHKSESPCESP-----YPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRH 1563
++ S P SP P +DK + ++ S KS +S G + +SR
Sbjct: 338 ENRSPSRRPGRSPKRRSLSPKPRDKSRRSRSPLLNDRRSKQSKSPSR-TLSPGRRAKSRS 396
Query: 1564 DKEKIEKKEKRDSSGGKEEKKHHKSSDKHR 1593
+ K + E+R S + + S + R
Sbjct: 397 LERKRREPERRRLSSPRTRPRDDILSRRER 426
Score = 62.4 bits (150), Expect = 3e-09
Identities = 85/361 (23%), Positives = 147/361 (40%), Gaps = 60/361 (16%)
Query: 1249 PKGNSSNGNSGSNS-NKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEER 1307
P+ +N N N V E+ + + K+KK K + K K K E
Sbjct: 13 PEMEDANSEKSINEENGEVSEDQSQNKHSRHKKKKHKHRS---------KHKKHKHSSEE 63
Query: 1308 PNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRER 1367
+KD+K + K K K K ++ D K + A+ + ++ ++R
Sbjct: 64 -DKDKKHKH---------KHKHKKHKRKEIIDASDKEGMSPAKRTKLDDLALLEDLEKQR 113
Query: 1368 DIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDS 1427
+ K E ++G ++ + L+ S+ E E +K R + + S S+ K
Sbjct: 114 ALIKAELDNELMEGKVQSGMGLILQGYESGSE-EEGEIHEKARNGNRSSTRSSSTKGKLE 172
Query: 1428 LIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSR----------ERSREREKKDEKD 1477
L++ K ++ K S+SKER + D KS+ RS+ +E+K K
Sbjct: 173 LVDNKITTKK-------RSKSRSKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKS 225
Query: 1478 RKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSG 1537
+R + + P L +R +E+ G K+ SP + +K K ++KSKS
Sbjct: 226 PSKRSKSQDQARKSKSPTLRRRSQEKIG-------KARSPTD-----DKVKIEDKSKSKD 273
Query: 1538 KEKGSDSFKSEKMDK-------ISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSD 1590
++K +S D+ + GK + R + K E+K KR + +EKK KS
Sbjct: 274 RKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSK-ERKSKRSET--DKEKKPIKSPS 330
Query: 1591 K 1591
K
Sbjct: 331 K 331
Score = 31.2 bits (69), Expect = 8.4
Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 5/66 (7%)
Query: 1528 KEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHK 1587
++ N KS +E G S + + +K S KK+ +H + KK K S K++K HK
Sbjct: 16 EDANSEKSINEENGEVS-EDQSQNKHSRHKKKKHKHRSK--HKKHKHSSEEDKDKK--HK 70
Query: 1588 SSDKHR 1593
KH+
Sbjct: 71 HKHKHK 76
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a [Homo
sapiens]
Length = 624
Score = 93.2 bits (230), Expect = 2e-18
Identities = 94/372 (25%), Positives = 164/372 (44%), Gaps = 59/372 (15%)
Query: 1209 SSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNS-----SNGNSGSNSN 1263
+ S I +A + + + E R RS K+ + + S + + S S ++ S S
Sbjct: 285 AQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSR 344
Query: 1264 KAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKE---------ERPNKDEKA 1314
+ + K K++ K ++ + + +R KD +EK KE E+ + EK
Sbjct: 345 QKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKE 404
Query: 1315 RET-KERTPKSDKEKEKFKKEEKAKD---EKFKTTVPNAESKSTQEREREKEPSRERDIA 1370
RE KER D++KE+ K EK K+ E+ + + +E+E++KE RE+D +
Sbjct: 405 REKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRS 464
Query: 1371 KEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIE 1430
KE+ K +TP S RS E ++RR + SP S T+K
Sbjct: 465 KEIDEKRKKDKKSRTPPRSYNASRRSRSSSRE---RRRRRSRSSSRSPRTSKTIK----- 516
Query: 1431 LKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRD----HS 1486
++SS +P P S++K +++ RE+E+ +R+ER+R S
Sbjct: 517 -RKSS------RSPSPRSRNK------------KDKKREKERDHISERRERERSTSMRKS 557
Query: 1487 NNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDK-----EKNKSKSSGKEKG 1541
+NDR+ K + E+N T K ++ P S DK E+NK + +G +
Sbjct: 558 SNDRD-----GKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQL 612
Query: 1542 SDSFKSEKMDKI 1553
++ S K + +
Sbjct: 613 NEENLSTKTEAV 624
Score = 84.3 bits (207), Expect = 8e-16
Identities = 82/352 (23%), Positives = 151/352 (42%), Gaps = 62/352 (17%)
Query: 1244 ASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKP 1303
+++ P+ SN G S + + K + K+ ++ + K++
Sbjct: 290 SAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRR 349
Query: 1304 KEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEP 1363
+ + P+K K +++ER + + K+++ + K K V + + +ERE+E+E
Sbjct: 350 RSKSPHK--KRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREK 407
Query: 1364 SRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSST 1423
+ER K+ + KE K EK E +RE++R K H
Sbjct: 408 EKERGKNKD-RDKEREKDREKDK---------------EKDREREREK-------EHE-- 442
Query: 1424 VKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKR 1483
KD K KE+E D K+ ++ ++RS+E ++K +KD+K R
Sbjct: 443 -KDR--------------------DKEKEKEQD-KEKEREKDRSKEIDEKRKKDKKSRTP 480
Query: 1484 DHS-NNDREVPPDLTKRRKEENGTMGVSKHKSES----PCESPYPNEKDKEKNKSKSSGK 1538
S N R +RR+ + + S S++ SP P ++K+ K +
Sbjct: 481 PRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKK-----R 535
Query: 1539 EKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSD 1590
EK D SE+ ++ S ++S +D++ EK EK +S +EK+H+K D
Sbjct: 536 EKERDHI-SERRERERSTSMRKSSNDRDGKEKLEKNSTS--LKEKEHNKEPD 584
Score = 71.2 bits (173), Expect = 7e-12
Identities = 72/317 (22%), Positives = 127/317 (40%), Gaps = 31/317 (9%)
Query: 1284 KTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFK 1343
K P TP+A K EE + +A+ + + K +K +++
Sbjct: 262 KPPEMTPQAAA-------KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRS 314
Query: 1344 TTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEP 1403
+ +++S S ++R + K SR + +S++ + K+P KS R
Sbjct: 315 KSRSSSKSHSRRKRSQSKHRSRSHN---RSRSRQKDRRRSKSPHKKRSKSRERRKSRSRS 371
Query: 1404 EREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDK-KDLDK 1462
KR+ DT VK+ E + K + KE+E K KD DK
Sbjct: 372 HSRDKRK--DTREKIKEKERVKEKDREKEREREK----------EREKEKERGKNKDRDK 419
Query: 1463 SRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPY 1522
RE+ RE++K+ +++R+ K + D+E + K ++ E K + +S
Sbjct: 420 EREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRT 479
Query: 1523 PNEKDKEKNKSKSSGKEK-------GSDSFKSEKMDKISSGGKKESRHDKEKIEKKEK-R 1574
P +S+SS +E+ S S ++ K K S R +K +K+EK R
Sbjct: 480 PPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKER 539
Query: 1575 DSSGGKEEKKHHKSSDK 1591
D + E++ S K
Sbjct: 540 DHISERRERERSTSMRK 556
Score = 66.6 bits (161), Expect = 2e-10
Identities = 68/292 (23%), Positives = 116/292 (39%), Gaps = 43/292 (14%)
Query: 1302 KPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREK 1361
KP E P + A + E K +E + F + E K+ + R + +
Sbjct: 262 KPPEMTP---QAAAKELEEVMKRVREAQSFISAA-IEPESGKSNERKGGRSRSHTRSKSR 317
Query: 1362 EPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHS 1421
S+ K +SK + + S S + RS P +R + R + + S SHS
Sbjct: 318 SSSKSHSRRKRSQSKHRSRSHNR---SRSRQKDRRRSKSPHKKRSKSRERRKSR-SRSHS 373
Query: 1422 STVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKER 1481
+ K++ K+ K KER + +KD +K RER +EREK+ E+ + +
Sbjct: 374 RDKR------KDTREKI----------KEKER-VKEKDREKEREREKEREKEKERGKNKD 416
Query: 1482 KRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKG 1541
+ DRE + + R+ E +EKD++K K K KEK
Sbjct: 417 RDKEREKDREKDKEKDREREREK------------------EHEKDRDKEKEKEQDKEKE 458
Query: 1542 SDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDKHR 1593
+ +S+++D+ KK + + R SS + ++ SS R
Sbjct: 459 REKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPR 510
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 93.2 bits (230), Expect = 2e-18
Identities = 101/420 (24%), Positives = 172/420 (40%), Gaps = 68/420 (16%)
Query: 1210 SSSIGSASKSDESSTEETDKSR-ERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKE 1268
S I S + D+ E+TDK + K ++K + + V
Sbjct: 111 SDIISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQE------KPERKIQTKVTH 164
Query: 1269 NDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEK 1328
+KEKGKEK +EK++ T + ++ + KEKP+ + K++K +T E++ + K++
Sbjct: 165 KEKEKGKEKVREKEKPEKKATHKEKI---EKKEKPETKTLAKEQKKAKTAEKSEEKTKKE 221
Query: 1329 EKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKEN---------- 1378
K K+EK K +T E + T + +EKE + ++K + +
Sbjct: 222 VKGGKQEKVK----QTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIF 277
Query: 1379 VKGGEKTPVSGSLKSPVPRSDIPEP--------EREQKRRKIDTHPSPSHSSTVKDSLIE 1430
V G K S ++ P+P P E+E +++K + + K+ + +
Sbjct: 278 VHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKK 337
Query: 1431 LKESSAKLYINHTPP----------------PLSKSKEREMDKKDLDKSRERSREREKKD 1474
E + + P +K E++ D K K E + + KK
Sbjct: 338 KSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQ 397
Query: 1475 EKDR------KERKRDHS-NNDREVPPDLTKRRKEENGTMGVSK---HKSESPCESPYPN 1524
EK K K++HS +D++V T+R KEE G + + K K E
Sbjct: 398 EKKEKHVEPAKSPKKEHSVPSDKQVKAK-TERAKEEIGAVSIKKAVPGKKEEKTTKTVEQ 456
Query: 1525 EKDKEKN-KSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEK 1583
E KEK+ K+ S K+K K EK+ S +KE KK+++ S GKE K
Sbjct: 457 EIRKEKSGKTSSILKDKEPIKGKEEKV--------PASLKEKEPETKKDEKMSKAGKEVK 508
Score = 79.0 bits (193), Expect = 4e-14
Identities = 97/409 (23%), Positives = 167/409 (40%), Gaps = 40/409 (9%)
Query: 1191 PPPRNAVASVQNGPGGGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPK 1250
PPP + + P G K+++ T ET K +E+ K+ + + K
Sbjct: 291 PPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSET-KKKEKEDIKKKSEKETAIDVEK 349
Query: 1251 ---GNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEER 1307
G +S G+ K + +K ++KE KK K PA + + GK ++K K
Sbjct: 350 KEPGKASETKQGTV--KIAAQAAAKKDEKKEDSKKTKKPAEVEQPK--GKKQEKKEKHVE 405
Query: 1308 PNKDEKARETKERTPKSDKEKEKFKKEEKAKDE----KFKTTVPNA-ESKSTQEREREKE 1362
P K K KE + SDK+ + K E+AK+E K VP E K+T+ E+E
Sbjct: 406 PAKSPK----KEHSVPSDKQVKA--KTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIR 459
Query: 1363 PSRERDIAKEMKSKENVKGGE-KTPVSGSLKSPVPRSDIP--------EPEREQKRRKID 1413
+ + +K KE +KG E K P S K P + D +P+ Q + K +
Sbjct: 460 KEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKE 519
Query: 1414 THPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKK 1473
P P K ++ E +++ P + ++K L + + + E K
Sbjct: 520 EKPEPQIKKEAKPAISE----KVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIE---K 572
Query: 1474 DEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKS 1533
K + +K +H RE P K K + G S+ ++ ++ KEK
Sbjct: 573 TAKPKPTKKAEH----REREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADM 628
Query: 1534 KSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEE 1582
K +EK S +S ++ ++ +K +R K+ + + + G E+
Sbjct: 629 KHLREEKVSTRKESLQLHNVTK-AEKPARVSKDVEDVPASKKAKEGTED 676
Score = 44.7 bits (104), Expect = 7e-04
Identities = 38/146 (26%), Positives = 63/146 (43%), Gaps = 8/146 (5%)
Query: 1452 EREMDKKDLDKSRERSRE--REKKDEKDRKERKRDHSNNDREVPPDLTK-RRKEENGTMG 1508
+ + DK ++D+ R +E ++K +++++ ERK +E K R KE+
Sbjct: 125 DEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKA 184
Query: 1509 VSKHKSESPCESPYPNEKDKEKNKSKSSGK--EKGSDSFKSEKMDKISSGGKKESRHDKE 1566
K K E E P KE+ K+K++ K EK K K +K+ K K
Sbjct: 185 THKEKIEKK-EKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKT 243
Query: 1567 KIEKKEKRDSSGGKEEKKHHKSSDKH 1592
+ KEK D K H+ D++
Sbjct: 244 PSKPKEKEDKE--KAAVSKHEQKDQY 267
Score = 42.0 bits (97), Expect = 0.005
Identities = 40/125 (32%), Positives = 59/125 (47%), Gaps = 26/125 (20%)
Query: 1467 SREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEK 1526
S E E+ D+ D D + + PP R+KE + K K+E E P +
Sbjct: 115 SSEDEEDDDGDE-----DTDKGEIDEPP---LRKKE------IHKDKTEKQ-EKPERKIQ 159
Query: 1527 DKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHH 1586
K +K K GKEK + K E K++ H KEKIEKKEK ++ +E+K
Sbjct: 160 TKVTHKEKEKGKEKVREKEKPE----------KKATH-KEKIEKKEKPETKTLAKEQKKA 208
Query: 1587 KSSDK 1591
K+++K
Sbjct: 209 KTAEK 213
Score = 32.0 bits (71), Expect = 4.9
Identities = 22/71 (30%), Positives = 35/71 (49%), Gaps = 1/71 (1%)
Query: 1523 PNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEE 1582
P + KE +K K+ +EK +++ K GK++ R +KEK EKK K+E
Sbjct: 136 PPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVR-EKEKPEKKATHKEKIEKKE 194
Query: 1583 KKHHKSSDKHR 1593
K K+ K +
Sbjct: 195 KPETKTLAKEQ 205
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [Homo
sapiens]
Length = 508
Score = 93.2 bits (230), Expect = 2e-18
Identities = 94/372 (25%), Positives = 164/372 (44%), Gaps = 59/372 (15%)
Query: 1209 SSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNS-----SNGNSGSNSN 1263
+ S I +A + + + E R RS K+ + + S + + S S ++ S S
Sbjct: 169 AQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSR 228
Query: 1264 KAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKE---------ERPNKDEKA 1314
+ + K K++ K ++ + + +R KD +EK KE E+ + EK
Sbjct: 229 QKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKE 288
Query: 1315 RET-KERTPKSDKEKEKFKKEEKAKD---EKFKTTVPNAESKSTQEREREKEPSRERDIA 1370
RE KER D++KE+ K EK K+ E+ + + +E+E++KE RE+D +
Sbjct: 289 REKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRS 348
Query: 1371 KEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIE 1430
KE+ K +TP S RS E ++RR + SP S T+K
Sbjct: 349 KEIDEKRKKDKKSRTPPRSYNASRRSRSSSRE---RRRRRSRSSSRSPRTSKTIK----- 400
Query: 1431 LKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRD----HS 1486
++SS +P P S++K +++ RE+E+ +R+ER+R S
Sbjct: 401 -RKSS------RSPSPRSRNK------------KDKKREKERDHISERRERERSTSMRKS 441
Query: 1487 NNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDK-----EKNKSKSSGKEKG 1541
+NDR+ K + E+N T K ++ P S DK E+NK + +G +
Sbjct: 442 SNDRD-----GKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQL 496
Query: 1542 SDSFKSEKMDKI 1553
++ S K + +
Sbjct: 497 NEENLSTKTEAV 508
Score = 84.3 bits (207), Expect = 8e-16
Identities = 82/352 (23%), Positives = 151/352 (42%), Gaps = 62/352 (17%)
Query: 1244 ASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKP 1303
+++ P+ SN G S + + K + K+ ++ + K++
Sbjct: 174 SAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRR 233
Query: 1304 KEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEP 1363
+ + P+K K +++ER + + K+++ + K K V + + +ERE+E+E
Sbjct: 234 RSKSPHK--KRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREK 291
Query: 1364 SRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSST 1423
+ER K+ + KE K EK E +RE++R K H
Sbjct: 292 EKERGKNKD-RDKEREKDREKDK---------------EKDREREREK-------EHE-- 326
Query: 1424 VKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKR 1483
KD K KE+E D K+ ++ ++RS+E ++K +KD+K R
Sbjct: 327 -KDR--------------------DKEKEKEQD-KEKEREKDRSKEIDEKRKKDKKSRTP 364
Query: 1484 DHS-NNDREVPPDLTKRRKEENGTMGVSKHKSES----PCESPYPNEKDKEKNKSKSSGK 1538
S N R +RR+ + + S S++ SP P ++K+ K +
Sbjct: 365 PRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKK-----R 419
Query: 1539 EKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSD 1590
EK D SE+ ++ S ++S +D++ EK EK +S +EK+H+K D
Sbjct: 420 EKERDHI-SERRERERSTSMRKSSNDRDGKEKLEKNSTS--LKEKEHNKEPD 468
Score = 71.2 bits (173), Expect = 7e-12
Identities = 72/317 (22%), Positives = 127/317 (40%), Gaps = 31/317 (9%)
Query: 1284 KTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFK 1343
K P TP+A K EE + +A+ + + K +K +++
Sbjct: 146 KPPEMTPQAAA-------KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRS 198
Query: 1344 TTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEP 1403
+ +++S S ++R + K SR + +S++ + K+P KS R
Sbjct: 199 KSRSSSKSHSRRKRSQSKHRSRSHN---RSRSRQKDRRRSKSPHKKRSKSRERRKSRSRS 255
Query: 1404 EREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDK-KDLDK 1462
KR+ DT VK+ E + K + KE+E K KD DK
Sbjct: 256 HSRDKRK--DTREKIKEKERVKEKDREKEREREK----------EREKEKERGKNKDRDK 303
Query: 1463 SRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPY 1522
RE+ RE++K+ +++R+ K + D+E + K ++ E K + +S
Sbjct: 304 EREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRT 363
Query: 1523 PNEKDKEKNKSKSSGKEK-------GSDSFKSEKMDKISSGGKKESRHDKEKIEKKEK-R 1574
P +S+SS +E+ S S ++ K K S R +K +K+EK R
Sbjct: 364 PPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKER 423
Query: 1575 DSSGGKEEKKHHKSSDK 1591
D + E++ S K
Sbjct: 424 DHISERRERERSTSMRK 440
Score = 66.6 bits (161), Expect = 2e-10
Identities = 68/292 (23%), Positives = 116/292 (39%), Gaps = 43/292 (14%)
Query: 1302 KPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREK 1361
KP E P + A + E K +E + F + E K+ + R + +
Sbjct: 146 KPPEMTP---QAAAKELEEVMKRVREAQSFISAA-IEPESGKSNERKGGRSRSHTRSKSR 201
Query: 1362 EPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHS 1421
S+ K +SK + + S S + RS P +R + R + + S SHS
Sbjct: 202 SSSKSHSRRKRSQSKHRSRSHNR---SRSRQKDRRRSKSPHKKRSKSRERRKSR-SRSHS 257
Query: 1422 STVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKER 1481
+ K++ K+ K KER + +KD +K RER +EREK+ E+ + +
Sbjct: 258 RDKR------KDTREKI----------KEKER-VKEKDREKEREREKEREKEKERGKNKD 300
Query: 1482 KRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKG 1541
+ DRE + + R+ E +EKD++K K K KEK
Sbjct: 301 RDKEREKDREKDKEKDREREREK------------------EHEKDRDKEKEKEQDKEKE 342
Query: 1542 SDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDKHR 1593
+ +S+++D+ KK + + R SS + ++ SS R
Sbjct: 343 REKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPR 394
>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
Length = 754
Score = 90.5 bits (223), Expect = 1e-17
Identities = 102/458 (22%), Positives = 180/458 (39%), Gaps = 53/458 (11%)
Query: 1174 KSRKSYMIPENEFHHKDPPPRNAVASVQNGPGGGPSSSSIGSASKSDESSTEETDKSRER 1233
KS+KS E+E + + P++ V + P S K+DE + ++ RER
Sbjct: 250 KSKKSAS-SESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADEKERKNRERERER 308
Query: 1234 SQCGVKAVNKASS-----TTPKGNSSNGN--------SGSNSNKAVKENDKEKGKEKEKE 1280
+C AS T G G S S S + ++ +E +
Sbjct: 309 -ECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQ 367
Query: 1281 KKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETK-------ERTPKSDKEKEKFKK 1333
+ ++ ++ E + G + +E + +E K +P EKEK K
Sbjct: 368 RAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVK 427
Query: 1334 EEKA------------KDEKFKTTVPNAESKSTQEREREKEPSRERDIA------KEMKS 1375
+ K+ KD+K+K V ++ + +EK S+ERD K M+S
Sbjct: 428 DHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRS 487
Query: 1376 K------ENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLI 1429
+ ENVK EK S RS + E K + D S +
Sbjct: 488 RSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSR 547
Query: 1430 ELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHS-NN 1488
E + K N S+S++R + R+RSR +E ++++ R+R S +
Sbjct: 548 ECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSR 607
Query: 1489 DREVPPDLTK---RRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSF 1545
+R PP ++ RR+ + + +S+S + Y N++ K ++ ++S EK
Sbjct: 608 ERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEK---RM 664
Query: 1546 KSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEK 1583
S+ D SS +E + D+++ + + SS E K
Sbjct: 665 YSKSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELK 702
Score = 86.7 bits (213), Expect = 2e-16
Identities = 86/369 (23%), Positives = 156/369 (42%), Gaps = 45/369 (12%)
Query: 1245 SSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPK 1304
SS++ +SS+ +S S+S + +D E E++ +K++K +R K+ K++ K
Sbjct: 193 SSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKN--SRKHKKEKKKRKK 250
Query: 1305 EERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKF--KTTVPNAESKSTQEREREKE 1362
++ E E E P+S E+ + +F + + P A+ K + RERE+E
Sbjct: 251 SKKSASSESEAENLEAQPQSTVRPEEIPP---IPENRFLMRKSPPKADEKERKNRERERE 307
Query: 1363 ---------PSRERDIAKEMKSKENVKGGE----KTPVSGSLKSPVPRSDIPEPEREQKR 1409
P+ + +S +KG +TP + RS+ P R++ +
Sbjct: 308 RECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQ 367
Query: 1410 RKIDTHPSPSHS--STVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERS 1467
R S K L E+KE+ P+ + + D +++ +S R
Sbjct: 368 RAQRMRVSSGERWIKGDKSELNEIKENQRS--------PVRVKERKITDHRNVSESPNRK 419
Query: 1468 REREKK---DEKDRKERK-RDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYP 1523
E+EKK + + KER R +S D + + KR K ++ + K KS+
Sbjct: 420 NEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNR 479
Query: 1524 NEKDKEKNKSKSSGKE-----------KGSDSFKSEKMDKISSGGKKESRHDKEKIEKKE 1572
NE+ + +++SK E KG D +S +K K + HD K ++K+
Sbjct: 480 NEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKD 539
Query: 1573 KRDSSGGKE 1581
+R S +E
Sbjct: 540 RRAQSRSRE 548
Score = 85.1 bits (209), Expect = 5e-16
Identities = 96/458 (20%), Positives = 178/458 (38%), Gaps = 77/458 (16%)
Query: 1180 MIPENEFHHKDPPPRNAVASVQNGPGGGPSSSSIGSASKSDESSTEETDKSRERSQCGVK 1239
+IP+++ ++ + +S + SSS S+S S +S + +KS++R
Sbjct: 177 LIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRK----- 231
Query: 1240 AVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATT---------P 1290
K + N K K++ K E E E E P +T P
Sbjct: 232 ----------KKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIP 281
Query: 1291 EARVLGKDGKEKPKEERPNKDEKARETKERTPKSD-----------KEKEKFK------- 1332
E R L + K E+ E+ RE + P S + K K
Sbjct: 282 ENRFLMRKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRY 341
Query: 1333 ---KEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSG 1389
+++D ++ P + Q +R + S ER I + +K +++PV
Sbjct: 342 RTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRV 401
Query: 1390 SLKSPVPRSDIPE-PERE-QKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPL 1447
+ ++ E P R+ +K +K+ H S S ++ + K+ K +
Sbjct: 402 KERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRN--SEKDDKYKNKVKKRAKSK 459
Query: 1448 SKSKEREMDKKDLDKSRERSREREKKDEKDRKERK--RDHSNNDREVPPDLTKRRKEENG 1505
S+SK +E KS+ER + + +EK + R RDH N K +++++
Sbjct: 460 SRSKSKEK-----SKSKERDSKHNRNEEKRMRSRSKGRDHEN---------VKEKEKQSD 505
Query: 1506 TMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDK 1565
+ G + +S S +S K E + SKS K++ + S +S + D I+ G + +
Sbjct: 506 SKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQS-RSRECD-ITKGKHSYNSRTR 563
Query: 1566 EKIEKKEK----------RDSSGGKEEKKHHKSSDKHR 1593
E+ +++ RD S KE ++ + + R
Sbjct: 564 ERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRR 601
Score = 82.4 bits (202), Expect = 3e-15
Identities = 94/394 (23%), Positives = 152/394 (38%), Gaps = 50/394 (12%)
Query: 1218 KSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKE---NDKEKG 1274
K D+S E K +RS VK + T + S + N + K VK+ N KE+
Sbjct: 382 KGDKSELNEI-KENQRSPVRVK---ERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERD 437
Query: 1275 --KEKEKEKKEKTPATTPEARVLGKDGKEKPK-EERPNKDEKARETKERTPKSDKEKEKF 1331
+ EK+ K K KEK K +ER +K + E + R+ ++ E
Sbjct: 438 IRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENV 497
Query: 1332 KKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSGSL 1391
K++EK D K K QER R KE S K+++SK N K+
Sbjct: 498 KEKEKQSDSKGKD----------QERSRSKEKS------KQLESKSNEHDHSKSKEKDRR 541
Query: 1392 KSPVPRS-DIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINH-------- 1442
R DI + + R + S S V+ + S +K Y +
Sbjct: 542 AQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRR 601
Query: 1443 ---------TPPPLSKSKEREMDKKDL---DKSRERSREREKKDEKDRKERKRDHSNNDR 1490
TPP S+SK+R ++D ++ +SR ++K ++ K R ++
Sbjct: 602 GRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESE 661
Query: 1491 EVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKM 1550
+ ++ N + + +SP + +D E S KE EK
Sbjct: 662 KRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKE 721
Query: 1551 DKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKK 1584
++ S G + + H+K KK +SS G +E K
Sbjct: 722 NQKSKGQENDHVHEK---NKKFDHESSPGTDEDK 752
Score = 34.3 bits (77), Expect = 0.99
Identities = 39/202 (19%), Positives = 69/202 (34%), Gaps = 10/202 (4%)
Query: 1402 EPEREQKRRKIDTHPSPSHSSTVKD--SLIELKESSAKLYINHTPPPLSKSKEREMDKKD 1459
E RE + +K D P + LI + + H S S + D
Sbjct: 149 EVVREIENQKTDAASKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSS 208
Query: 1460 LDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSK-------- 1511
+S S + E E+ K+RK+ H N R+ + KR+K + S+
Sbjct: 209 DSQSSSDSSDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQP 268
Query: 1512 HKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKK 1571
+ P E P E KS EK + + E+ + + + + + + + +
Sbjct: 269 QSTVRPEEIPPIPENRFLMRKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTR 328
Query: 1572 EKRDSSGGKEEKKHHKSSDKHR 1593
R G + S + R
Sbjct: 329 SGRKIKGRGPRRYRTPSRSRSR 350
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 88.6 bits (218), Expect = 4e-17
Identities = 86/415 (20%), Positives = 160/415 (38%), Gaps = 17/415 (4%)
Query: 1183 ENEFHHKDPPPRNAVASVQN---GPGGGPSSSSIGSASKSDESSTEETDKSRERSQCGVK 1239
E E + PP + A + PG + +S S+S+ +E D+ ++ Q GVK
Sbjct: 92 EEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVK 151
Query: 1240 AVNKASSTTPK-GNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKD 1298
KA+ PK SS+ +S S+S +N K K + + K P A +
Sbjct: 152 PQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIAN 211
Query: 1299 GKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQERE 1358
GK + + +++E + +K KK+ AK T P +S S+++
Sbjct: 212 GKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSS 271
Query: 1359 REKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSP 1418
++E +++ + + +V P SL + P+ + E++Q +
Sbjct: 272 SDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAV---EKQQPVESSEDSSDE 328
Query: 1419 SHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDR 1478
S SS+ ++ K +K PPP K+ E D D D S + +
Sbjct: 329 SDSSSEEEKKPPTKAVVSK--ATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKN 386
Query: 1479 KERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGK 1538
K + V P ++ G +++ S E + ++++ K ++ K
Sbjct: 387 SSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTK 446
Query: 1539 EKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDKHR 1593
K + K + G ++S D + SS +EE+K KS+ K +
Sbjct: 447 PKATAKAALSLPAKQAPQGSRDSSSDSD--------SSSSEEEEEKTSKSAVKKK 493
Score = 80.9 bits (198), Expect = 9e-15
Identities = 94/426 (22%), Positives = 177/426 (41%), Gaps = 24/426 (5%)
Query: 1174 KSRKSYMIPENEFHHKDPPPRNAVASVQNGPGGGPSSSSIGSASKSDESSTEE-----TD 1228
K++K + P PP+ A A+ + G SSSS S+S S + S EE
Sbjct: 181 KNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPK 240
Query: 1229 KSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPAT 1288
K+ + Q KA KA++T + +SS+ +S S+ +E K+ K K P +
Sbjct: 241 KTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDE----EEEQKKPMKNKPGPYSSVPPPS 296
Query: 1289 TPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKK-EEKAKDEKFKTTVP 1347
P + K +P ++ K + +++ + +SD E+ KK KA K T P
Sbjct: 297 APPPK---KSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPP 353
Query: 1348 NAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQ 1407
A+ + + S E D A + K V + KSP + +
Sbjct: 354 PAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAV--TTKSPAVKPAAAPKQPVG 411
Query: 1408 KRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERS 1467
+K+ T + S SS + S E +E + K+ P +K+ K+ SR+ S
Sbjct: 412 GGQKLLTRKADSSSSEEESSSSE-EEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSS 470
Query: 1468 REREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKD 1527
+ + ++ +E+ S + + P + K K+ES S + +
Sbjct: 471 SDSDSSSSEEEEEKT---SKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSE 527
Query: 1528 KEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKR----DSSGGKEEK 1583
+E+ K K G + + K+ +++ K +++ +E+ E+K+K SG +++
Sbjct: 528 EEEEKLKGKGSPR-PQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKR 586
Query: 1584 KHHKSS 1589
K ++++
Sbjct: 587 KQNEAA 592
Score = 76.6 bits (187), Expect = 2e-13
Identities = 101/408 (24%), Positives = 163/408 (39%), Gaps = 51/408 (12%)
Query: 1192 PPRNAVASVQNGPGGGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKG 1251
PP+ AV Q P SS S+ +SD SS EE K KA K
Sbjct: 308 PPKKAVEKQQ------PVESSEDSSDESDSSSEEE--KKPPTKAVVSKATTKPPPAKKAA 359
Query: 1252 NSSNGNSGSNSNKAVKENDKEKGKEKEKEKKE----KTPATTPEARVLGKDGKEKPKEER 1307
SS+ +S S+S++ + K G K K K+PA P A PK+
Sbjct: 360 ESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAA---------PKQ-- 408
Query: 1308 PNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRER 1367
P + T++ S +E+ +EEK K + TT P A +K+ ++ P R
Sbjct: 409 PVGGGQKLLTRKADSSSSEEESSSSEEEKTK-KMVATTKPKATAKAALSLPAKQAPQGSR 467
Query: 1368 DIAKEMKSKENVKGGEKTPVSGSLKSP--VPRSDIPEPEREQKRRKIDTHPSPSHSSTVK 1425
D + + S + + EKT S K P V P K+ K ++ S+SS+
Sbjct: 468 DSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAES----SNSSSSD 523
Query: 1426 DSLIELKESSAKLYINHTP-PPLSKSKEREMDKKDLDKSRERSREREKKDEK-------- 1476
DS +E KL +P P K+ K+ + S E E++ +K
Sbjct: 524 DS---SEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKS 580
Query: 1477 -DRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKE-----K 1530
K+RK++ + + E P K+ K + + K E SP+ +++E +
Sbjct: 581 GSLKKRKQNEAAKEAETPQ--AKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSR 638
Query: 1531 NKSKSSGKEKGSDSFKSEKMDKISSGGK-KESRHDKEKIEKKEKRDSS 1577
S ++G+ E+ +++ K K RH+K K ++ R S
Sbjct: 639 VADNSFDAKRGAAGDWGERANQVLKFTKGKSFRHEKTKKKRGSYRGGS 686
Score = 57.4 bits (137), Expect = 1e-07
Identities = 80/399 (20%), Positives = 145/399 (36%), Gaps = 61/399 (15%)
Query: 1243 KASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKE------KKEKTPAT---TPEAR 1293
K++ + +NG + K +D E E+E+E KK PA P +
Sbjct: 59 KSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGK 118
Query: 1294 VLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKS 1353
K + EE + D++ + K+ K K + K KA +K K++ +++S S
Sbjct: 119 AAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQ---AKAAKAPPKKAKSSDSDSDSSS 175
Query: 1354 TQEREREKEP--------SRERDIAKEMKSKENVKGGEKTPVSGSLKS------------ 1393
E + ++P ++ + K ++ + G+ S S S
Sbjct: 176 EDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKA 235
Query: 1394 -PVPRSDIPEPEREQKRR-KIDTHPSPSHSSTVKDSLIELKESSAKLYINHTP------- 1444
P+ +P+ + K K T P+ SS+ S E +E + P
Sbjct: 236 AATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPP 295
Query: 1445 --PPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKE 1502
PP KS + KK ++K + + DE D S+++ E P +
Sbjct: 296 SAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESD--------SSSEEEKKPPTKAVVSK 347
Query: 1503 ENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSD----------SFKSEKMDK 1552
+K +ES +S + + ++ SK +G K S + K K
Sbjct: 348 ATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPK 407
Query: 1553 ISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDK 1591
GG ++ K E+ SS +E+ K ++ K
Sbjct: 408 QPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTK 446
>gi|154146223 splicing factor, arginine/serine-rich 130 [Homo sapiens]
Length = 805
Score = 88.6 bits (218), Expect = 4e-17
Identities = 88/410 (21%), Positives = 163/410 (39%), Gaps = 60/410 (14%)
Query: 1184 NEFHHKDPPPRNAVASVQNGPGGGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNK 1243
NEF HK+ +N+++ ++ G + ++ +T + +E + +
Sbjct: 456 NEFIHKE---QNSLSLLEAREADG---DVVNEKKRTPNETTSVLEPKKEHKE------KE 503
Query: 1244 ASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKP 1303
+ G+SS+G+S SNS + + +T + + P
Sbjct: 504 KQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRS-----------SSP 552
Query: 1304 KEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEP 1363
K ++ + ++ K R +S + K E K + + + +ER R + P
Sbjct: 553 KRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSP 612
Query: 1364 SRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSST 1423
SRER ++ +S R++ R + RRKID ++
Sbjct: 613 SRERRRSRS-------------------RSRDRRTNRASRSRSRDRRKIDDQRGNLSGNS 653
Query: 1424 VKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKR 1483
K E KE K K + R +DK K +ER RE++K+ EK ++E K
Sbjct: 654 HKHKG-EAKEQERK-----------KERSRSIDKDRKKKDKEREREQDKRKEKQKREEK- 700
Query: 1484 DHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSD 1543
D + ++ D KR++E T S+ S S + + +D +K+ +K S K GSD
Sbjct: 701 DFKFSSQD---DRLKRKRESERTF--SRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSD 755
Query: 1544 SFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDKHR 1593
S + S +K+++ K + ++ GK+ + HKS + R
Sbjct: 756 SSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRSR 805
Score = 52.4 bits (124), Expect = 4e-06
Identities = 74/346 (21%), Positives = 126/346 (36%), Gaps = 75/346 (21%)
Query: 1297 KDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQE 1356
++G EK + E+ K EK R ++R+ S KKE+KA ++ P +S +
Sbjct: 237 REGLEKMEREKQKKLEKERMEQQRSQLS-------KKEKKATEDAEGGDGPRLPQRSKFD 289
Query: 1357 REREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRR------ 1410
+ E+E + ENV+ V+ S SPVP+ + +PE ++ +
Sbjct: 290 SDEEEEDT------------ENVEAASSGKVTRS-PSPVPQEEHSDPEMTEEEKEYQMML 336
Query: 1411 ----------------KIDTHPSPSHSSTVKDSLIELKESSAKLYIN--------HTPPP 1446
+I +H K +L +SSA + +
Sbjct: 337 LTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDS 396
Query: 1447 LSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRD-----HSNNDREVPPDLTKR-- 1499
+ +R + D D R R R+K++ RKE+++ +++ +TK
Sbjct: 397 EDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMN 456
Query: 1500 ---RKEENGTM---------GVSKHKSESPCES-----PYPNEKDKEKNKSKSSGKEKGS 1542
KE+N V K +P E+ P K+KEK SG
Sbjct: 457 EFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSG 516
Query: 1543 DSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKS 1588
S + + SS S + R SS K +K+H +S
Sbjct: 517 SSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSR-SSSPKRKKRHSRS 561
Score = 34.3 bits (77), Expect = 0.99
Identities = 31/127 (24%), Positives = 54/127 (42%), Gaps = 8/127 (6%)
Query: 1418 PSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKD 1477
P + S + + S L + PP + K R + + + RE++KK EK+
Sbjct: 195 PQNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKE 254
Query: 1478 RKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSG 1537
R E++R + + T+ + +G + K +S E E+D E ++ SSG
Sbjct: 255 RMEQQRSQLSKKEK---KATEDAEGGDGPRLPQRSKFDSDEE-----EEDTENVEAASSG 306
Query: 1538 KEKGSDS 1544
K S S
Sbjct: 307 KVTRSPS 313
Score = 32.7 bits (73), Expect = 2.9
Identities = 22/90 (24%), Positives = 38/90 (42%), Gaps = 6/90 (6%)
Query: 1493 PPDLTKRRKEENGTMGVSKHKSESPCESPY---PNEKDKEKNKSKSSGKEKGSDSFKSEK 1549
PP + R+E + + + SP P P + D K ++ + +G + + EK
Sbjct: 191 PPAPPQNRRERPSSF---RDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREK 247
Query: 1550 MDKISSGGKKESRHDKEKIEKKEKRDSSGG 1579
K+ ++ R K EKK D+ GG
Sbjct: 248 QKKLEKERMEQQRSQLSKKEKKATEDAEGG 277
>gi|154146193 splicing factor, arginine/serine-rich 130 [Homo sapiens]
Length = 805
Score = 88.6 bits (218), Expect = 4e-17
Identities = 88/410 (21%), Positives = 163/410 (39%), Gaps = 60/410 (14%)
Query: 1184 NEFHHKDPPPRNAVASVQNGPGGGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNK 1243
NEF HK+ +N+++ ++ G + ++ +T + +E + +
Sbjct: 456 NEFIHKE---QNSLSLLEAREADG---DVVNEKKRTPNETTSVLEPKKEHKE------KE 503
Query: 1244 ASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKP 1303
+ G+SS+G+S SNS + + +T + + P
Sbjct: 504 KQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRS-----------SSP 552
Query: 1304 KEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEP 1363
K ++ + ++ K R +S + K E K + + + +ER R + P
Sbjct: 553 KRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSP 612
Query: 1364 SRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSST 1423
SRER ++ +S R++ R + RRKID ++
Sbjct: 613 SRERRRSRS-------------------RSRDRRTNRASRSRSRDRRKIDDQRGNLSGNS 653
Query: 1424 VKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKR 1483
K E KE K K + R +DK K +ER RE++K+ EK ++E K
Sbjct: 654 HKHKG-EAKEQERK-----------KERSRSIDKDRKKKDKEREREQDKRKEKQKREEK- 700
Query: 1484 DHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSD 1543
D + ++ D KR++E T S+ S S + + +D +K+ +K S K GSD
Sbjct: 701 DFKFSSQD---DRLKRKRESERTF--SRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSD 755
Query: 1544 SFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDKHR 1593
S + S +K+++ K + ++ GK+ + HKS + R
Sbjct: 756 SSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRSR 805
Score = 52.4 bits (124), Expect = 4e-06
Identities = 74/346 (21%), Positives = 126/346 (36%), Gaps = 75/346 (21%)
Query: 1297 KDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQE 1356
++G EK + E+ K EK R ++R+ S KKE+KA ++ P +S +
Sbjct: 237 REGLEKMEREKQKKLEKERMEQQRSQLS-------KKEKKATEDAEGGDGPRLPQRSKFD 289
Query: 1357 REREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRR------ 1410
+ E+E + ENV+ V+ S SPVP+ + +PE ++ +
Sbjct: 290 SDEEEEDT------------ENVEAASSGKVTRS-PSPVPQEEHSDPEMTEEEKEYQMML 336
Query: 1411 ----------------KIDTHPSPSHSSTVKDSLIELKESSAKLYIN--------HTPPP 1446
+I +H K +L +SSA + +
Sbjct: 337 LTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDS 396
Query: 1447 LSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRD-----HSNNDREVPPDLTKR-- 1499
+ +R + D D R R R+K++ RKE+++ +++ +TK
Sbjct: 397 EDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMN 456
Query: 1500 ---RKEENGTM---------GVSKHKSESPCES-----PYPNEKDKEKNKSKSSGKEKGS 1542
KE+N V K +P E+ P K+KEK SG
Sbjct: 457 EFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSG 516
Query: 1543 DSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKS 1588
S + + SS S + R SS K +K+H +S
Sbjct: 517 SSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSR-SSSPKRKKRHSRS 561
Score = 34.3 bits (77), Expect = 0.99
Identities = 31/127 (24%), Positives = 54/127 (42%), Gaps = 8/127 (6%)
Query: 1418 PSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKD 1477
P + S + + S L + PP + K R + + + RE++KK EK+
Sbjct: 195 PQNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKE 254
Query: 1478 RKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSG 1537
R E++R + + T+ + +G + K +S E E+D E ++ SSG
Sbjct: 255 RMEQQRSQLSKKEK---KATEDAEGGDGPRLPQRSKFDSDEE-----EEDTENVEAASSG 306
Query: 1538 KEKGSDS 1544
K S S
Sbjct: 307 KVTRSPS 313
Score = 32.7 bits (73), Expect = 2.9
Identities = 22/90 (24%), Positives = 38/90 (42%), Gaps = 6/90 (6%)
Query: 1493 PPDLTKRRKEENGTMGVSKHKSESPCESPY---PNEKDKEKNKSKSSGKEKGSDSFKSEK 1549
PP + R+E + + + SP P P + D K ++ + +G + + EK
Sbjct: 191 PPAPPQNRRERPSSF---RDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREK 247
Query: 1550 MDKISSGGKKESRHDKEKIEKKEKRDSSGG 1579
K+ ++ R K EKK D+ GG
Sbjct: 248 QKKLEKERMEQQRSQLSKKEKKATEDAEGG 277
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 87.8 bits (216), Expect = 8e-17
Identities = 123/470 (26%), Positives = 194/470 (41%), Gaps = 101/470 (21%)
Query: 1210 SSSIGSASKSDESS-------TEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSG--- 1259
SS+ G+ K D+ T+ K++E+ QC + K S T + S S
Sbjct: 613 SSAEGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAI 672
Query: 1260 ------SNSNKA-VKENDKEKGKEKEK------EKKE---KTPATTPEARVLGKDGKEKP 1303
S NK V ++D++ K++EK E+KE K + + KD
Sbjct: 673 LLENDLSTENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSF 732
Query: 1304 KEE--RPNKDEKARETKERTPKSDK---EKEKFKKEEKAKDEKFKTTVPNAESKSTQERE 1358
+EE R NK EK R KE++PK +K KE+ KK+ K + K + E K ++E+E
Sbjct: 733 REEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEKE 792
Query: 1359 REKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQ-----KRRKID 1413
+ + +E+ + KE +E+ E + L++ + + + +R++ D
Sbjct: 793 KIFKEDKEK-LKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFD 851
Query: 1414 THPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMD---------------KK 1458
S S V D +S AKL + SKER D KK
Sbjct: 852 FKGEDSWDSPVTDYRDMKSDSVAKLILETVK---EDSKERRRDSRAREKRDYREPFFRKK 908
Query: 1459 D---LDKSRERSREREKK--------DEKDRKERKRDHSNNDREVPPDLTKRRKE----- 1502
D LDK+ E+ +E+ +K EKD+K R+ + DR+ + K R++
Sbjct: 909 DRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKP 968
Query: 1503 ---------ENGTMGVSKHKSES-------PCESPYP-NEKDKEKNKSKSSG-------- 1537
E G K KS+ P E +P EK+K+ K
Sbjct: 969 EEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPERY 1028
Query: 1538 KEKGSDSFKSEKMDKISSGGKKESRHD---KEKIEKKEKRDSSGGKEEKK 1584
KEK SD KSEK I +K+ D KEK + KEK + GK++++
Sbjct: 1029 KEKSSDKDKSEK--SILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKER 1076
Score = 78.6 bits (192), Expect = 5e-14
Identities = 85/367 (23%), Positives = 157/367 (42%), Gaps = 47/367 (12%)
Query: 1218 KSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEK 1277
+ D + E E +CG ++ K S G+ G + +E +K+ G +K
Sbjct: 961 RRDGRAKPEEAHREELKECGCESGFKDKSD---GDFGKGLEPWERHHPAREKEKKDGPDK 1017
Query: 1278 EKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKA 1337
E+++K K E+ KE+ +KD+ + E+ K DKE +K KE+K
Sbjct: 1018 ERKEKTKP---------------ERYKEKSSDKDKSEKSILEKCQK-DKEFDKCFKEKKD 1061
Query: 1338 KDEKFKTTV-PNAESKSTQEREREKEPSRERDIAKE--MKSKENVKGGEKTPVSGSLKSP 1394
EK K T + E K++ ++ +EK+ I E + K++ KG EK+
Sbjct: 1062 TKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYI------ 1115
Query: 1395 VPRSDIPEPEREQKRRKI--DTHPSPSHSSTVKDSLIELKESSAKLYIN--HTPPPLSKS 1450
+DI E E R S + ++ KE + Y + H +
Sbjct: 1116 ---ADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDKQH 1172
Query: 1451 KEREMDKKDLDKSRERSRE---REKKDE-----KDRKERKRDHSNNDRE----VPPDLTK 1498
ER+ DK+ D+ ++R R+KK++ K++K+++ DR+ V K
Sbjct: 1173 PERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDK 1232
Query: 1499 RRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGK 1558
+ K++ KH +E +S + + DKE +K + S + ++ EK+++ +
Sbjct: 1233 KNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADAEKSLLEKLEEEALHEY 1292
Query: 1559 KESRHDK 1565
+E +DK
Sbjct: 1293 REDSNDK 1299
Score = 68.9 bits (167), Expect = 4e-11
Identities = 103/501 (20%), Positives = 174/501 (34%), Gaps = 95/501 (18%)
Query: 1182 PENEFHHKDPPPRNAVASVQNGPGGGPSSSSIGSASKSDESSTEETDKSRERSQC----- 1236
P E KD P + + P SS KS++S E+ K +E +C
Sbjct: 1005 PAREKEKKDGPDKERKEKTK--PERYKEKSS--DKDKSEKSILEKCQKDKEFDKCFKEKK 1060
Query: 1237 ----------GVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEK--------- 1277
G KAS K G S ++ D +KGKEK
Sbjct: 1061 DTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFT 1120
Query: 1278 ------------------------------EKEKKEKTPATTPEARVLGKDGKEKPKEER 1307
EKE+ + A+ + K E+ K++
Sbjct: 1121 DESEDDRDSCMGSGFKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPERQKDKE 1180
Query: 1308 PNKDEK-------ARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQERERE 1360
P K R+ KE+ + KEK+ + EK KD K + +V + + K +++ E
Sbjct: 1181 PRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPE 1240
Query: 1361 KEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSH 1420
K + K + E + S +S + E E+ + +
Sbjct: 1241 KAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADAEKSLLEKLEEEALHEYREDSNDKI 1300
Query: 1421 SSTVKDSLIELKES---SAKLYINHTPPP-----------LSKSKEREMDKKDLDKSRE- 1465
S DS + + +A L ++ T PP K KE+E + S++
Sbjct: 1301 SEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSSKKS 1360
Query: 1466 RSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVS-------KHKSESPC 1518
RER KK++ ++KE+ D+ ++ E GVS + + +
Sbjct: 1361 HDRERAKKEKAEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDELDKTI 1420
Query: 1519 ESPYPNEKDKEKNKSKSSGK-EKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSS 1577
E +KDK ++ + S K EK + S ++ + K+E +K + EK+ RD
Sbjct: 1421 ELFSTEKKDKNDSEREPSKKIEKELKPYGSSAINILKEKKKREKHREKWRDEKERHRDRH 1480
Query: 1578 GG-------KEEKKHHKSSDK 1591
E +HH+ K
Sbjct: 1481 ADGLLRHHRDELLRHHRDEQK 1501
Score = 62.8 bits (151), Expect = 3e-09
Identities = 112/497 (22%), Positives = 190/497 (38%), Gaps = 89/497 (17%)
Query: 1154 EEKEKRPDLYALAMGYSGQLKSRKSYMIPENEFHHKDPPPRNAVASVQNGPGGGPSSSSI 1213
+EKE+ + YA S + + PE + KD PR+ G +
Sbjct: 1150 QEKEEGREAYA-----SDRHRKSSDKQHPERQ---KDKEPRDRRKDRGAADAGRDKKEKV 1201
Query: 1214 GSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEK 1273
K ++ E T+K ++R ++AS + + + + K DK K
Sbjct: 1202 FEKHK-EKKDKESTEKYKDRK-------DRASVDSTQDKKNKQKLPEKAEKKHAAEDKAK 1253
Query: 1274 GKEKEKEKKE------KTPATTPEARVLGKDGKEKPKEERPNKDEKARETKE-------- 1319
K KEK KE + + E +L K +E E R + ++K E
Sbjct: 1254 SKHKEKSDKEHSKERKSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQ 1313
Query: 1320 -------------RTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRE 1366
P DK +E EK K EK + ++ SK + +RER K+ E
Sbjct: 1314 EPGLTAFLEVSFTEPPGDDKPRESACLPEKLK-EKERHRHSSSSSKKSHDRERAKKEKAE 1372
Query: 1367 RDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDI----------PEPEREQKRRKIDTHP 1416
K+ K ++ +GG + SG + +D E E ++ T
Sbjct: 1373 ----KKEKGEDYKEGGSRKD-SGQYEKDFLEADAYGVSYNMKADIEDELDKTIELFSTEK 1427
Query: 1417 SPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSRE------- 1469
+ S + S + E K Y + L + K+RE ++ +ER R+
Sbjct: 1428 KDKNDSEREPS--KKIEKELKPYGSSAINILKEKKKREKHREKWRDEKERHRDRHADGLL 1485
Query: 1470 REKKDEKDRKER-KRDHSNNDREVPPDLTK-RRKEENGTMGVSKHKSESPCESPYPNEKD 1527
R +DE R R ++ + D++ PP + K + ++E +G +K K + + EK+
Sbjct: 1486 RHHRDELLRHHRDEQKPATRDKDSPPRVLKDKSRDEGPRLGDAKLKEKFKDGA----EKE 1541
Query: 1528 KEKNKSKSSGKEKGSDSFKSEKMD-------------KISSGGKKESRHDKEKIEKKEKR 1574
K S+G +K + S K D ++S + S+ D E IE++ KR
Sbjct: 1542 KGDPVKMSNGNDKVAPSKDPGKKDARPREKLLGDGDLMMTSFERMLSQKDLE-IEERHKR 1600
Query: 1575 DSSGGKE-EKKHHKSSD 1590
K+ EK H+S D
Sbjct: 1601 HKERMKQMEKLRHRSGD 1617
Score = 62.0 bits (149), Expect = 4e-09
Identities = 86/396 (21%), Positives = 151/396 (38%), Gaps = 76/396 (19%)
Query: 1264 KAVKENDKEKGKEKEKEKK--EKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERT 1321
K + E KE KE+ ++ + EK P R +D +K E+R + EK +
Sbjct: 875 KLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYL 934
Query: 1322 PKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKG 1381
S+K+K++ + E +D K ES + R K R+ KE + K
Sbjct: 935 --SEKDKKRRESAEAGRDRK-----DALESCKERRDGRAKPEEAHREELKECGCESGFKD 987
Query: 1382 GEKTPVSGSLKS--------PVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKE 1433
L+ + D P+ ER++K + S + S++E +
Sbjct: 988 KSDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDKDKSEKSILEKCQ 1047
Query: 1434 SSAKLYINHTPPPLSKSKEREMDKKD------LDKSRERSRER----------EKKDEKD 1477
+ +K K ++ KD LD+ +E+ + EKKD+K
Sbjct: 1048 KDKEFDKCFKEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKK 1107
Query: 1478 RKERK-------RDHSNNDRE--------------VPPDLTKRRKEENGTMGVS-KHKSE 1515
KE+ D S +DR+ +P + KEE S +H+
Sbjct: 1108 GKEKSWYIADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQEKEEGREAYASDRHRKS 1167
Query: 1516 SPCESPYPNEKDKE-KNKSKSSG-------------------KEKGSDSFKSEKMDKISS 1555
S + P +KDKE +++ K G K+K S ++ D+ S
Sbjct: 1168 SDKQHP-ERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRKDRASV 1226
Query: 1556 GGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDK 1591
++ ++ ++ EK EK+ ++ K + KH + SDK
Sbjct: 1227 DSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDK 1262
Score = 47.8 bits (112), Expect = 9e-05
Identities = 92/427 (21%), Positives = 148/427 (34%), Gaps = 81/427 (18%)
Query: 1214 GSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEK 1273
G+ + S+ESSTE +++ A S P + N+ S K +K K
Sbjct: 287 GTYTSSEESSTESSEEE------------DAPSFAPSSSVDGNNTDSEFEKGLKHKAKNP 334
Query: 1274 GKEK------------EKEKKEKTPATTPEARVLGKDGKEKPKEER----PNKDEKARET 1317
+K E +++++ P + +L KD +++ K P + K+ T
Sbjct: 335 EPQKATAPVKDEYEFDEDDEQDRVPPVD-DKHLLKKDYRKETKSNSFISIPKMEVKSY-T 392
Query: 1318 KERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKE 1377
K T K + + +++ T + + + +RE AK+ K K
Sbjct: 393 KNNTIAPKKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNAKQQKEKN 452
Query: 1378 NVKGGEKTPVSGSLKSPVPRSD---IPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKES 1434
VK K G RSD E E E D S S +K S + LK+
Sbjct: 453 KVKKKRKKETKGREVRFGKRSDKFCSSESESESSESGEDDRDSLGSSGCLKGSPLVLKDP 512
Query: 1435 S------AKLYINHTPPPLSKSKEREMDK----------KDLDKSRERSREREKKDEKDR 1478
S A +H K D+ K + + R
Sbjct: 513 SLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLSDSTRTR 572
Query: 1479 KERKRDHSNNDREVPP-DLTKRRKEENGTMGVSKHKSE--SPCESPYPN-EKD-----KE 1529
+ D+S+ V ++R+E +S+ KS S E P +K+ K
Sbjct: 573 LTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKEGKVVKKH 632
Query: 1530 KNKSKSSGKEKGSDSFKSE---------------KMDK-------ISSGGK-KESRHDKE 1566
K K K KEKG S E K DK +S+ K K +HD++
Sbjct: 633 KTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKLKVLKHDRD 692
Query: 1567 KIEKKEK 1573
+K+EK
Sbjct: 693 HFKKEEK 699
>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
Length = 494
Score = 84.0 bits (206), Expect = 1e-15
Identities = 78/334 (23%), Positives = 143/334 (42%), Gaps = 29/334 (8%)
Query: 1214 GSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEK 1273
GS + S + +SR RS+ K+ +++ S+ + S S S S K + +
Sbjct: 178 GSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQ 237
Query: 1274 GKEKEKEKKEKTPATTPEARVLGKDGKEKPK-----EERPNKDEKARETKERTPKSDKEK 1328
+ + K++K ++P+ GK + K EE+ ++ + K R+P K K
Sbjct: 238 SRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSK 297
Query: 1329 EK--FKKEEKAKDEKFKTTVPNAES-----KSTQEREREKEPSRERDIAKEMKSKENVKG 1381
K + +E+ +E+ + +V S + ++ R R K SR R ++ KSK+ KG
Sbjct: 298 SKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRS-KSKDKRKG 356
Query: 1382 GEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYIN 1441
+++ +S RS + E+ R++ S + SS K KE + +
Sbjct: 357 RKRSREESRSRS---RS---RSKSERSRKRGSKRDSKAGSSKKKK-----KEDTDR--SQ 403
Query: 1442 HTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRK 1501
P S SKERE K + + R ++ + R R +S + +P + R K
Sbjct: 404 SRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSK 463
Query: 1502 EENGTMGVSKHKSESPCESPYPNEKDKEKNKSKS 1535
+ T SK +S S SP + + ++ S+S
Sbjct: 464 SASKTRSRSKSRSRSASRSP---SRSRSRSHSRS 494
Score = 63.2 bits (152), Expect = 2e-09
Identities = 74/343 (21%), Positives = 132/343 (38%), Gaps = 70/343 (20%)
Query: 1270 DKEKGKEKE-----------KEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETK 1318
D KG++ E K EK T R K + E++P + ++
Sbjct: 134 DAHKGRKNEGVIEFVSYSDMKRALEKLDGTEVNGR------KIRLVEDKPGSRRRRSYSR 187
Query: 1319 ERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQ-EREREKEPSRERDIAKEMKSKE 1377
R+ + + + ++ +++ K++ + S+S R R K SR + ++ K K
Sbjct: 188 SRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKS 247
Query: 1378 NVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAK 1437
P +E+ R + +H + S KD E +++
Sbjct: 248 R-----------------------SPSKEKSRSR--SHSAGKSRSKSKDQAEEKIQNN-- 280
Query: 1438 LYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLT 1497
++ P S+S R K KSR RS+ER ++EK R + R L
Sbjct: 281 ---DNVGKPKSRSPSRHKSKS---KSRSRSQERRVEEEK------RGSVSRGRSQEKSLR 328
Query: 1498 KRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGG 1557
+ R + G S+ +S S +S KDK K + +S + + +S+ G
Sbjct: 329 QSRSRSR-SKGGSRSRSRSRSKS-----KDKRKGRKRSREESRSRSRSRSKSERSRKRGS 382
Query: 1558 KKESRHDKEKIEKKEKRDSSGGK-------EEKKHHKSSDKHR 1593
K++S+ K +KKE D S + +E++H KS R
Sbjct: 383 KRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQR 425
Score = 62.8 bits (151), Expect = 3e-09
Identities = 64/302 (21%), Positives = 122/302 (40%), Gaps = 23/302 (7%)
Query: 1300 KEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQERER 1359
K + + ++ R+ + K + + + +++ +K K+ P+ E ++
Sbjct: 203 KSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSA 262
Query: 1360 EKEPSRERDIAKE-MKSKENV-KGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPS 1417
K S+ +D A+E +++ +NV K ++P KS E+KR + S
Sbjct: 263 GKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRS 322
Query: 1418 PSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKE-REMDKKDLDKSRERSREREKKDEK 1476
S S K S + SKSK+ R+ K+ ++SR RSR R K +
Sbjct: 323 QEKSLRQSRSRSRSKGGSRSRSRSR-----SKSKDKRKGRKRSREESRSRSRSRSKSERS 377
Query: 1477 DRKERKRDH-SNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKN---- 1531
++ KRD + + ++ + T R + + + VSK + + ES + + +N
Sbjct: 378 RKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTN 437
Query: 1532 -----KSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHH 1586
+S+S+ K K + SE + S K SR K + S + H
Sbjct: 438 QETRSRSRSNSKSK--PNLPSESRSRSKSASKTRSR---SKSRSRSASRSPSRSRSRSHS 492
Query: 1587 KS 1588
+S
Sbjct: 493 RS 494
Score = 58.9 bits (141), Expect = 4e-08
Identities = 59/294 (20%), Positives = 113/294 (38%), Gaps = 26/294 (8%)
Query: 1309 NKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERD 1368
++ +R+++ R+ S K + ++ + ++S+S ++E+ + PS+E+
Sbjct: 196 SRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKS 255
Query: 1369 IAK-----EMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSST 1423
++ + +SK + EK + ++ P RS P R + + K +
Sbjct: 256 RSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRS----PSRHKSKSKSRSRSQERRVEE 311
Query: 1424 VKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRK---- 1479
K + S K L +S+ R K +SR RSR + K K RK
Sbjct: 312 EKRGSVSRGRSQEK--------SLRQSRSRSRSKGG-SRSRSRSRSKSKDKRKGRKRSRE 362
Query: 1480 -ERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPN---EKDKEKNKSKS 1535
R R S + E +R + G+ K + +S P+ K++E KS+S
Sbjct: 363 ESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSES 422
Query: 1536 SGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSS 1589
S +E +S + + S + S+ + R S K + S
Sbjct: 423 SQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRS 476
>gi|151301171 RNA polymerase II transcription factor TAFII140 [Homo
sapiens]
Length = 929
Score = 84.0 bits (206), Expect = 1e-15
Identities = 103/385 (26%), Positives = 154/385 (40%), Gaps = 51/385 (13%)
Query: 1208 PSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVK 1267
P S GS S+ D ++ + E + KA A++ T G++ SG S+
Sbjct: 406 PFEFSSGSESEGDIFTSPKRISGPECTT--PKASTSANNFTKSGSTPLPLSGGTSSSDNS 463
Query: 1268 ENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKE 1327
E ++ K TP+ P P P K E K + P S +
Sbjct: 464 WTMDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPL--HKVYEEKTKLPSSVEV 521
Query: 1328 KEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPV 1387
K+K KKE K K +K ++R+RE+E + +D +KE K+ VK EK
Sbjct: 522 KKKLKKELKTKMKK-----------KEKQRDREREKDKNKDKSKE---KDKVKEKEKDKE 567
Query: 1388 SGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPL 1447
+G + + E E + + KI +KD L+ ++ K
Sbjct: 568 TGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHK---------- 617
Query: 1448 SKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTM 1507
K K+RE KKD DK RE+EK +K R+++ + + P L KE +
Sbjct: 618 DKKKDREKGKKDKDK-----REKEKVKDKGREDKMKAPA-------PPLVLPPKELALPL 665
Query: 1508 GVSKHKSESPCESP-----YPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESR 1562
S P P P + +EK K K K+K K +K K KKE
Sbjct: 666 FSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDK---KEKKKKKEKEKEKKEKE 722
Query: 1563 HDKEKIEKKEKRDSSGGKEEKKHHK 1587
+KEK E+ EKR+ KE+ KH K
Sbjct: 723 REKEKRER-EKREKE--KEKHKHEK 744
Score = 66.2 bits (160), Expect = 2e-10
Identities = 89/393 (22%), Positives = 156/393 (39%), Gaps = 63/393 (16%)
Query: 1157 EKRPDLYALAMGYSGQLKSRKSYMIPENEFHHKDPPPRNAVASVQNGPGGGPSSSSIGSA 1216
E+ PD + + SG + P+ + P+ + ++ G G
Sbjct: 401 EREPDPFEFS---SGSESEGDIFTSPKRISGPECTTPKASTSANNFTKSGSTPLPLSGGT 457
Query: 1217 SKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKE 1276
S SD S T + + V KA TP ++ N S+ +V E
Sbjct: 458 SSSDNSWTMDASID--------EVVRKAKLGTP--SNMPPNFPYISSPSVSPPTPEP-LH 506
Query: 1277 KEKEKKEKTPATTPEARVLGKD------GKEKPKEERPNKDEKARETKERTPKSDKEKEK 1330
K E+K K P++ + L K+ KEK ++ KD+ ++KE+ +KEK+K
Sbjct: 507 KVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDK 566
Query: 1331 ------------FKKEEKAKDEKFKTTV-----PNAESKS---TQEREREKEPSRERDIA 1370
F KEE+A KFK P + K +E+E+ K+ ++R+
Sbjct: 567 ETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKG 626
Query: 1371 KEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIE 1430
K+ K K + + +K+P P +P E SP+ +S V L
Sbjct: 627 KKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLF------SPATASRVPAMLPS 680
Query: 1431 LKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDR 1490
L + P L + KE K +E+ ++++KK++K +KE++++ +R
Sbjct: 681 L--------LPVLPEKLFEEKE---------KVKEKEKKKDKKEKKKKKEKEKEKKEKER 723
Query: 1491 EVPPDLTKRRKEENGTMGVSKHKSESPCESPYP 1523
E ++R++E K K E +P P
Sbjct: 724 EKEKREREKREKEKEKHKHEKIKVEPVALAPSP 756
Score = 53.9 bits (128), Expect = 1e-06
Identities = 90/439 (20%), Positives = 162/439 (36%), Gaps = 53/439 (12%)
Query: 1182 PENEFHHKDPPPRNAVASVQNGPGGGPSSSS---IGSASKSDESSTEETDKSRERSQCGV 1238
P + + + PP + VQ+ P S + +KS + + + +
Sbjct: 215 PLSSINTQKIPPMLSPVHVQDSTDLAPPSPEPPMLAPVAKSQMPTAKPLETKSFTPKTKT 274
Query: 1239 KAVNKASST-TPKGNSSNGNSGS--NSNKAVKENDKEKGKEKEKEKKEKTPATT--PEAR 1293
K + T +PK S GS S K V + K G+ K + + TT P+
Sbjct: 275 KTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGRSKSPKSPKSPKVTTHIPQTP 334
Query: 1294 VLGKDGKEKPK---EERPNKDEKARETKERTPKSDK-EKEKFKKEEKAKDEKFKTTVPNA 1349
V + P E+ +K+ + + P + K E K+ D+ + ++
Sbjct: 335 VRPETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAVVADKTIEASIDAV 394
Query: 1350 ESKSTQEREREK---------------EPSR----ERDIAKEMKSKENVKGGEKTPV--- 1387
+++ ERE + P R E K S N TP+
Sbjct: 395 IARACAEREPDPFEFSSGSESEGDIFTSPKRISGPECTTPKASTSANNFTKSGSTPLPLS 454
Query: 1388 ---SGSLKSPVPRSDIPEPEREQKRRKIDTHP-------SPSHSSTVKDSLIELKESSAK 1437
S S S + I E R+ K P SPS S + L ++ E K
Sbjct: 455 GGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTK 514
Query: 1438 LYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLT 1497
L P S ++++ K+ K +++ ++R+++ EKD+ + K + +E D
Sbjct: 515 L-------PSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKE 567
Query: 1498 KRRKEENGTMGVSKHKSESPCESPYPNEKDKE-KNKSKSSGKEKGSDSFKSEKMDKISSG 1556
R+ + K + P + +D + K K K K + K +K D+ G
Sbjct: 568 TGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDR-EKG 626
Query: 1557 GKKESRHDKEKIEKKEKRD 1575
K + + +KEK++ K + D
Sbjct: 627 KKDKDKREKEKVKDKGRED 645
Score = 42.0 bits (97), Expect = 0.005
Identities = 45/151 (29%), Positives = 68/151 (45%), Gaps = 23/151 (15%)
Query: 1267 KENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEK---PKEERPNKDEK----ARETKE 1319
KE K+K K++EK KK+K + + G++ K K P P K+ + T
Sbjct: 613 KEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATAS 672
Query: 1320 RTP------------KSDKEKEKFKKEEKAKDEKFKTTVPNAE-SKSTQEREREKEPSRE 1366
R P K +EKEK +EK K + K E K +E+EREKE RE
Sbjct: 673 RVPAMLPSLLPVLPEKLFEEKEKV--KEKEKKKDKKEKKKKKEKEKEKKEKEREKE-KRE 729
Query: 1367 RDIAKEMKSKENVKGGEKTPVSGSLKSPVPR 1397
R+ ++ K K + + PV+ + +PR
Sbjct: 730 REKREKEKEKHKHEKIKVEPVALAPSPVIPR 760
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 81.6 bits (200), Expect = 5e-15
Identities = 68/239 (28%), Positives = 107/239 (44%), Gaps = 55/239 (23%)
Query: 1267 KENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDK 1326
KE + E+ KE+ + +K K R GK KEK E + + E+ + +E+ K +
Sbjct: 53 KERESERKKERREREKRKREREKERKRERGK--KEKKGERKKEERERKKRRREKENKEGE 110
Query: 1327 EKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTP 1386
EKEK KK+EK E+ +T S + +ERE++ R+R+ KE + K+ +
Sbjct: 111 EKEKRKKKEKK--ERGRT--------SKEGKERERKEERKREERKERERKKEER------ 154
Query: 1387 VSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPP 1446
E ERE+K RK V + E KE K
Sbjct: 155 ---------------EKERERKERK------KRERKQVGEKEEERKEKERK--------- 184
Query: 1447 LSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENG 1505
+ K+RE ++K+ K RER RE+K E+ +KE ++ DR+ T R++E G
Sbjct: 185 --ERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQ-----TNWREKERG 236
Score = 76.3 bits (186), Expect = 2e-13
Identities = 71/283 (25%), Positives = 124/283 (43%), Gaps = 71/283 (25%)
Query: 1307 RPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRE 1366
+P + RE +ER ++ KE +K ++ E+ K+ + + ++REREKE RE
Sbjct: 31 QPGWQSEIRE-REREIETRKEGKKERESERKKERR---------EREKRKREREKERKRE 80
Query: 1367 RDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKD 1426
R K+ KG K + ERE+K+R+ +
Sbjct: 81 R-------GKKEKKGERK-----------------KEERERKKRRREK------------ 104
Query: 1427 SLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERK-RDH 1485
E KE K K ++ +KK+ ++ + +ERE+K+E+ R+ERK R+
Sbjct: 105 ---ENKEGE------------EKEKRKKKEKKERGRTSKEGKERERKEERKREERKERER 149
Query: 1486 SNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSF 1545
+RE + +R+K E +G K E E K +E+N+ KE+ +
Sbjct: 150 KKEEREKERERKERKKRERKQVG---EKEEERKEKERKERKKRERNR-----KERKKERE 201
Query: 1546 KSEKMDKISSGGKKESR-HDKEKIEKKEKRDSSGGKEEKKHHK 1587
+ E+ ++ KKE R +++K + R+ GK E+K K
Sbjct: 202 RKERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKERK 244
Score = 70.5 bits (171), Expect = 1e-11
Identities = 44/151 (29%), Positives = 79/151 (52%), Gaps = 13/151 (8%)
Query: 1449 KSKEREMDKKDLDKSRERSRER--------EKKDEKDRKERKRDHSNNDREVPPDLTKRR 1500
K + RE +K+ ++ +ER RER KK+E++RK+R+R+ N + E K+
Sbjct: 60 KKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKE 119
Query: 1501 KEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKE 1560
K+E G SK E + E+ KE+ + K +EK + + +K ++ G K+E
Sbjct: 120 KKERGR--TSKEGKERERKEERKREERKERERKKEE-REKERERKERKKRERKQVGEKEE 176
Query: 1561 SRHDKEKIEKKEKRDSSGGKEEKKHHKSSDK 1591
R +KE+ E+K++ + KE KK + ++
Sbjct: 177 ERKEKERKERKKRERNR--KERKKERERKER 205
Score = 69.7 bits (169), Expect = 2e-11
Identities = 41/171 (23%), Positives = 80/171 (46%), Gaps = 7/171 (4%)
Query: 1214 GSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEK 1273
G K E EE ++ + R + K + K G + + ++ ++++
Sbjct: 82 GKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKR 141
Query: 1274 GKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKK 1333
+ KE+E+K+ E R ++ KE+ K ER EK E KE+ K K++E+ +K
Sbjct: 142 EERKERERKK-------EEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRK 194
Query: 1334 EEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEK 1384
E K + E+ + E K +ER++E++ R+ + ++ + K K +K
Sbjct: 195 ERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245
Score = 67.0 bits (162), Expect = 1e-10
Identities = 44/162 (27%), Positives = 75/162 (46%), Gaps = 3/162 (1%)
Query: 1226 ETDKSRERSQCGVKAVNKASSTTPKGN--SSNGNSGSNSNKAVKENDKEKGK-EKEKEKK 1282
E ++ RER + K K K G K K+ KE+G+ KE +++
Sbjct: 74 EKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKER 133
Query: 1283 EKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKF 1342
E+ E R + KE+ ++ER K+ K RE K+ K ++ KEK +KE K ++
Sbjct: 134 ERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNR 193
Query: 1343 KTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEK 1384
K E K +ER++E++ ER ++ + N + E+
Sbjct: 194 KERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKER 235
Score = 65.9 bits (159), Expect = 3e-10
Identities = 46/177 (25%), Positives = 82/177 (46%), Gaps = 18/177 (10%)
Query: 1214 GSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEK 1273
G + E E ++ + + + + + KG + KEN + +
Sbjct: 51 GKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGE 110
Query: 1274 GKEKEKEKKEKTPATTPEARVLGKDGKEKP-KEERPNKDEKARETKERTPKSDKEKEKFK 1332
KEK K+K++K T K+GKE+ KEER ++ K RE K+ + ++E+++ K
Sbjct: 111 EKEKRKKKEKKERGRT------SKEGKERERKEERKREERKERERKKEEREKERERKERK 164
Query: 1333 ---------KEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVK 1380
KEE+ K+++ K ++ +++ERE++ RER KE K KE K
Sbjct: 165 KRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRER--KKERKKKEERK 219
Score = 63.5 bits (153), Expect = 2e-09
Identities = 59/247 (23%), Positives = 104/247 (42%), Gaps = 50/247 (20%)
Query: 1345 TVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPE 1404
T P +S+ +ERERE E +E +E + K+ + EK R E E
Sbjct: 30 TQPGWQSE-IREREREIETRKEGKKERESERKKERREREK------------RKREREKE 76
Query: 1405 REQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSR 1464
R+++R K KE + K +ERE K+ +K
Sbjct: 77 RKRERGK--------------------KEKKGE----------RKKEERERKKRRREKEN 106
Query: 1465 ERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPN 1524
+ E+EK+ +K++KER R + +R++EE K + E E
Sbjct: 107 KEGEEKEKRKKKEKKERGRTSKEGKERERKE--ERKREERKERERKKEEREKERE----- 159
Query: 1525 EKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKK 1584
K+++K + K G+++ K K K +KE + ++E+ E++E++ KEE+K
Sbjct: 160 RKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERK 219
Query: 1585 HHKSSDK 1591
+ D+
Sbjct: 220 KERQKDR 226
>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
[Homo sapiens]
Length = 651
Score = 81.6 bits (200), Expect = 5e-15
Identities = 78/350 (22%), Positives = 142/350 (40%), Gaps = 40/350 (11%)
Query: 1252 NSSNGNSGSNS---NKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERP 1308
N S NS + S K K++ K+ K+ + E + +++ + K+ K+ K++
Sbjct: 267 NYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDV 326
Query: 1309 NKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERD 1368
KD ++ + + K +++ K K++ KD+K K T ES T+ + + + R+
Sbjct: 327 KKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRN 386
Query: 1369 IAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSL 1428
+ K K+ + K +K S +S + + + E++ K KDS
Sbjct: 387 LKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDK----------------KDSK 430
Query: 1429 IELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHS-- 1486
+ K+S + + E + D K K ++ ++ KKD+K + +K S
Sbjct: 431 TDNKKS-----VKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTE 485
Query: 1487 -NNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSF 1545
+D E+ D K KE+ G+ K + ES + K K+S K KGSD+
Sbjct: 486 MESDLELKKD-KKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTE 544
Query: 1546 KSEKM------------DKISSGGKKESRHDKEKIEKKEKRDSSGGKEEK 1583
E + D S+ K E K K+ + K EK
Sbjct: 545 SEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEK 594
Score = 76.3 bits (186), Expect = 2e-13
Identities = 99/425 (23%), Positives = 174/425 (40%), Gaps = 70/425 (16%)
Query: 1205 GGGP----SSSSIGSASKSDESST---EETDKSRERSQCGVKAVNKASSTTPKGNSSNGN 1257
GG P S GS + + ES E+T + E + +K+ ++ + +SS N
Sbjct: 123 GGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETN 182
Query: 1258 SGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARET 1317
S ++K V +N +K K+ K K+ T E + K+ K + + D +
Sbjct: 183 PESQNSKTVSKNCSQKDKKDSKNSKK----TNTEFLHTKNNPKKDLKRSKTSNDPISEIC 238
Query: 1318 KERT---------PKSDKEKEKF-----------KKEEKAKDEKF--KTTVPNAESKSTQ 1355
E + +SD E F K K K+ K T NA+ S
Sbjct: 239 SENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDA 298
Query: 1356 EREREKEPSRE-----RDIAKEMKSKENVKGGEKTPV-SGSLKSPVPRSDIPEPEREQKR 1409
E E K+ ++ +++ K+ K K+ K E T SG K R D + +++ K+
Sbjct: 299 ESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDE--RKDTKKDKKKLKK 356
Query: 1410 --RKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERS 1467
+K DT P + T + + S L SK+ +++ D K + S +
Sbjct: 357 DDKKKDTKKYPESTDTESGDAKDARNDSRNL------KKASKNDDKKKDAKKITFSTDSE 410
Query: 1468 REREKKD-EKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEK 1526
E E K+ +KD K+ K+D ++++ + +E T S+ K +S +K
Sbjct: 411 SELESKESQKDEKKDKKDSKTDNKK------SVKNDEESTDADSEPKGDSK-----KGKK 459
Query: 1527 DKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKE-KIEKKEKRDSSGGKEEKKH 1585
D++K K S +K D+ K+ + ++ S D E K +KK ++ G K++ K
Sbjct: 460 DEKKGKKDSKKDDKKKDAKKNAESTEMES--------DLELKKDKKHSKEKKGSKKDIKK 511
Query: 1586 HKSSD 1590
D
Sbjct: 512 DARKD 516
Score = 68.2 bits (165), Expect = 6e-11
Identities = 83/335 (24%), Positives = 138/335 (41%), Gaps = 44/335 (13%)
Query: 1267 KENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDK 1326
K + K+ +K K++K TP L KD K+K N + K + E K
Sbjct: 107 KTHLKKAEYKKSKDEKGGTP--------LKKDSKKKGGSYATNPESK--QIVEEKTKRQN 156
Query: 1327 EKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTP 1386
E +K + ++E+ K +SKS+ E E + S+ K K++ K +KT
Sbjct: 157 EADKTPLKSSHENEQSK------KSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTN 210
Query: 1387 VSGSLKSPVPRSDIPEPEREQKRRKIDTHPSP---SHSSTVKDSLIELKESSAK-----L 1438
P+ D+ KR K P S +S D L+ + +S +
Sbjct: 211 TEFLHTKNNPKKDL-------KRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDA 263
Query: 1439 YINHTPPPLSKS---KEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPD 1495
++ + SK+ K + KKD K+ ++S + E +D KD K+D + V D
Sbjct: 264 WLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKD---AKKDSKKVKKNVKKD 320
Query: 1496 LTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISS 1555
K++ + T +S E KD +K+K K +K D+ K + S
Sbjct: 321 -DKKKDVKKDTESTDAESGDSKDE-----RKDTKKDKKKLKKDDKKKDTKKYPESTDTES 374
Query: 1556 GGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSD 1590
G K++R+D ++K K D K+ KK S+D
Sbjct: 375 GDAKDARNDSRNLKKASKNDDK-KKDAKKITFSTD 408
Score = 65.5 bits (158), Expect = 4e-10
Identities = 76/344 (22%), Positives = 144/344 (41%), Gaps = 37/344 (10%)
Query: 1267 KENDKEKGK---EKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTP- 1322
K++ EKG +K+ +KK + AT PE++ + ++ K +R N+ +K TP
Sbjct: 116 KKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEE-----KTKRQNEADK-------TPL 163
Query: 1323 KSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGG 1382
KS E E+ KK + + + ++ SK+ +++++ + ++ + + +K N K
Sbjct: 164 KSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKD 223
Query: 1383 EKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYI-- 1440
K S S P S+I + S S L ++++K Y
Sbjct: 224 LKR----SKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLK 279
Query: 1441 ------NHTPPPLSKSKEREM-DKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVP 1493
T KS + E D KD K ++ ++ KKD+K +K+ K+D + D E
Sbjct: 280 YTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDK-KKDVKKDTESTDAESG 338
Query: 1494 PDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSG------KEKGSDSFKS 1547
+R+ + + K + + YP D E +K + K+ + K
Sbjct: 339 DSKDERKDTKKDKKKLKKDDKKKDTKK-YPESTDTESGDAKDARNDSRNLKKASKNDDKK 397
Query: 1548 EKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDK 1591
+ KI+ ES + ++ +K EK+D K + K +D+
Sbjct: 398 KDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDE 441
Score = 65.5 bits (158), Expect = 4e-10
Identities = 81/369 (21%), Positives = 154/369 (41%), Gaps = 76/369 (20%)
Query: 1215 SASKSDESSTEETDKSRERSQC---GVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDK 1271
+A KS ++ +E++ +++ S+ VK +K S++ SG + ++ K+ K
Sbjct: 291 NAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDER-KDTKK 349
Query: 1272 EKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNK-----DEKARETKERTPKSDK 1326
+K K K+ +KK+ T D K+ + R K D+K ++ K+ T +D
Sbjct: 350 DKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDS 409
Query: 1327 EKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTP 1386
E E ESK +Q+ E++ + + D +K++VK E++
Sbjct: 410 ESE-------------------LESKESQKDEKKDKKDSKTD------NKKSVKNDEEST 444
Query: 1387 VSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPP 1446
+ S P+ D + ++++K+ K KDS + K+ AK
Sbjct: 445 DADS----EPKGDSKKGKKDEKKGK-------------KDSKKDDKKKDAK--------- 478
Query: 1447 LSKSKEREMDKKDLDKSRERSREREKKDEKD--RKERKRDHSNNDREVPPDLTKRRKEEN 1504
K+ E + DL+ +++ +EKK K +K+ ++D + D E K
Sbjct: 479 --KNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTST 536
Query: 1505 GTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFK-----------SEKMDKI 1553
G S +SE P +K E + + ++ K +G +S + +EK +K
Sbjct: 537 KIKG-SDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKA 595
Query: 1554 SSGGKKESR 1562
S+G SR
Sbjct: 596 STGRVPPSR 604
Score = 59.7 bits (143), Expect = 2e-08
Identities = 51/194 (26%), Positives = 93/194 (47%), Gaps = 23/194 (11%)
Query: 1210 SSSIGSASKSDESSTEETDKSRERSQCGVKAVNK--ASSTTPKGNSSNGNSGSNSNKAVK 1267
S+ S DE + DK + + K K S+ T G++ + + S + K
Sbjct: 332 STDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKAS 391
Query: 1268 ENDKEKGKEKEKEKKEKTPATTPEARVLGKDG-KEKPKEERPNKDEKARETK-------- 1318
+ND +K+K+ K+ T +T E+ + K+ K++ K+++ +K + + K
Sbjct: 392 KND-----DKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDA 446
Query: 1319 ERTPKSDKEK----EKFKKEEKAKDEKFKTTVPNAES---KSTQEREREKEPSRERDIAK 1371
+ PK D +K EK K++ KD+K K NAES +S E +++K+ S+E+ +K
Sbjct: 447 DSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSK 506
Query: 1372 EMKSKENVKGGEKT 1385
+ K+ K E T
Sbjct: 507 KDIKKDARKDTEST 520
Score = 48.1 bits (113), Expect = 7e-05
Identities = 78/345 (22%), Positives = 134/345 (38%), Gaps = 68/345 (19%)
Query: 1303 PKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNA-ESKSTQEREREK 1361
PK + ++K+R K + + +K K ++ +K + + + + RE+
Sbjct: 38 PKPLQRGTNDKSRPLKSQITVTRHDKRKLEEGQKPAHKWIRHSFRKILQWPPIYTAAREQ 97
Query: 1362 EPSRERDIAK------EMKSKENVKGGEKTPVS-GSLKSPVPRSDIPEPER---EQKRRK 1411
P R +K E K ++ KGG TP+ S K + PE ++ E+ +R+
Sbjct: 98 TPFRHLYTSKTHLKKAEYKKSKDEKGG--TPLKKDSKKKGGSYATNPESKQIVEEKTKRQ 155
Query: 1412 IDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSRERE 1471
+ +P SS + + K SS + +SK+ ++ DKKD S++ + E
Sbjct: 156 NEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQK-DKKDSKNSKKTNTEFL 214
Query: 1472 KKDEKDRKERKRDHSNND------------------------REVPPDLTKRRKEENGTM 1507
+K+ KR ++ND + D R +N +
Sbjct: 215 HTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSK 274
Query: 1508 GVSKHKSESPCESPYPNEKDKEKNKSKSSGKE------------------KGSDSFKSEK 1549
S ++ +KD +KN KSS E K D K K
Sbjct: 275 NYSLKYTKY-------TKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVK 327
Query: 1550 MDKIS----SGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSD 1590
D S SG K+ R D +K +KK K+D K+ KK+ +S+D
Sbjct: 328 KDTESTDAESGDSKDERKDTKKDKKKLKKDDK-KKDTKKYPESTD 371
Score = 45.1 bits (105), Expect = 6e-04
Identities = 36/171 (21%), Positives = 72/171 (42%), Gaps = 7/171 (4%)
Query: 1210 SSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKEN 1269
S+ S +S ES +E ++ K+V +T + G+S K
Sbjct: 406 STDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGK 465
Query: 1270 DKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKE 1329
K +K+K+ K+ +T E+ + K K+ KE++ +K + ++ ++ T +D E +
Sbjct: 466 KDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFD 525
Query: 1330 KFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVK 1380
+ K FKT+ + T+ E +P ++ I + + N K
Sbjct: 526 ESSK------TGFKTST-KIKGSDTESEESLYKPGAKKKIDESDGTSANSK 569
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 80.5 bits (197), Expect = 1e-14
Identities = 63/237 (26%), Positives = 103/237 (43%), Gaps = 50/237 (21%)
Query: 1258 SGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKE-ERPNKDEKARE 1316
S S+ +K + + E+ KE+ + +K K R GK K+K K+ ER + E+ R+
Sbjct: 21 SCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRK 80
Query: 1317 TKERTPKSDKEKE--KFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMK 1374
+E+ K +EKE K KKE+K ++ K + + K +ERERE + RER K K
Sbjct: 81 EREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRK 140
Query: 1375 SKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKES 1434
K K + + ER++K+RK +
Sbjct: 141 KKRR-------------KERKREKERGKRERKRKKRKKE--------------------- 166
Query: 1435 SAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDRE 1491
+ K+RE ++K+ K RER RE+K E+ ++ RK+ DR+
Sbjct: 167 -------------EREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRK 210
Score = 65.5 bits (158), Expect = 4e-10
Identities = 41/152 (26%), Positives = 71/152 (46%), Gaps = 9/152 (5%)
Query: 1449 KSKEREMDKKDLDKSRERSREREKKDEKDRKERKR--DHSNNDREVPPDLTKRRKEENGT 1506
K + RE +K+ ++ +ER RER KK++K RK+R+R + +E +RR++E
Sbjct: 37 KKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRK 96
Query: 1507 MGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDK-------ISSGGKK 1559
K K E +K KE+ + + K++ K + K GK+
Sbjct: 97 RKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKR 156
Query: 1560 ESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDK 1591
E + K K E++EK+ KE KK + ++
Sbjct: 157 ERKRKKRKKEEREKKRERNRKERKKERERKER 188
Score = 64.3 bits (155), Expect = 9e-10
Identities = 36/144 (25%), Positives = 71/144 (49%), Gaps = 6/144 (4%)
Query: 1449 KSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMG 1508
+ KERE +K+ +K R+ RE+E++ K K+++ RE K++KE
Sbjct: 71 RGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRE-----RKKKKERKERER 125
Query: 1509 VSKHKSESPCESPYPNEKDKEKNKSKSSGK-EKGSDSFKSEKMDKISSGGKKESRHDKEK 1567
+K + E + ++ KE+ + K GK E+ K E+ +K +KE + ++E+
Sbjct: 126 ENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERER 185
Query: 1568 IEKKEKRDSSGGKEEKKHHKSSDK 1591
E++E++ + KK + D+
Sbjct: 186 KERRERKKERKKERRKKKERKKDR 209
Score = 62.0 bits (149), Expect = 4e-09
Identities = 59/245 (24%), Positives = 99/245 (40%), Gaps = 50/245 (20%)
Query: 1302 KPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREK 1361
KP +R ++ +K R +E K +E+EK +K E+ K EK K ++RER K
Sbjct: 27 KPCTQRESERKKERRERE---KRKREREKERKRERGKKEK----------KKRKKRERGK 73
Query: 1362 EPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHS 1421
E R+R ++ + + K K K R RE+K++K
Sbjct: 74 ERERKRKEREKQRKERREKERRKRK-----KEKKKRERKQRGRRERKKKK---------- 118
Query: 1422 STVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKER 1481
E KE + + RE +K K R++ R +E+K EK+R +R
Sbjct: 119 --------ERKERERE-----------NKQRRERKRK---KRRKKKRRKERKREKERGKR 156
Query: 1482 KRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKG 1541
+R +E +R ++E K + E E K KE+ K + + ++
Sbjct: 157 ERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQTD 216
Query: 1542 SDSFK 1546
S F+
Sbjct: 217 SQVFR 221
Score = 61.6 bits (148), Expect = 6e-09
Identities = 42/170 (24%), Positives = 76/170 (44%), Gaps = 5/170 (2%)
Query: 1221 ESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKE 1280
E + ++ +ER + K K +G + + +KE+ K K+++
Sbjct: 42 EREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEK 101
Query: 1281 KKEKTPATTPEARVLGKDGKEKPKE--ERPNKDEKARETKERTPKSDKEKEKFKKEEKAK 1338
KK + R K+ KE+ +E +R + K R K+R + +EKE+ K+E K K
Sbjct: 102 KKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRK 161
Query: 1339 DEKFKTTVPNAE---SKSTQEREREKEPSRERDIAKEMKSKENVKGGEKT 1385
K + E + +ERER++ R+++ KE + K+ K KT
Sbjct: 162 KRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKT 211
Score = 60.1 bits (144), Expect = 2e-08
Identities = 60/264 (22%), Positives = 111/264 (42%), Gaps = 78/264 (29%)
Query: 1327 EKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTP 1386
++E +K+E+ + EK K REREKE RER ++ K K+ +G
Sbjct: 31 QRESERKKERREREKRK-------------REREKERKRERGKKEKKKRKKRERG----- 72
Query: 1387 VSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPP 1446
ERE+KR++ + + KE K
Sbjct: 73 ----------------KERERKRKEREK---------------QRKERREK--------- 92
Query: 1447 LSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGT 1506
+ ++R+ +KK ++ + RER+KK K+RKER+R++ +RR+ +
Sbjct: 93 --ERRKRKKEKKKRERKQRGRRERKKK--KERKERERENK-----------QRRERKRKK 137
Query: 1507 MGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKE 1566
K + E E + K K + K ++K + K K ++ +++ R +++
Sbjct: 138 RRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKER-----ERKERRERK 192
Query: 1567 KIEKKEKRDSSGGKEEKKHHKSSD 1590
K KKE+R K+++K + +D
Sbjct: 193 KERKKERRKKKERKKDRKTDRQTD 216
Score = 58.5 bits (140), Expect = 5e-08
Identities = 39/147 (26%), Positives = 74/147 (50%), Gaps = 4/147 (2%)
Query: 1449 KSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLT-KRRKEENGTM 1507
K K+RE K+ K +ER ++R+++ EK+R++RK++ +R+ K++KE
Sbjct: 65 KRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERE 124
Query: 1508 GVSKHKSESPCESPYPNEKDKEKNKSKSSGK-EKGSDSFKSEKMDKISSGGKKESRHDKE 1566
+K + E + ++ KE+ + K GK E+ K E+ +K +KE + KE
Sbjct: 125 RENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERK--KE 182
Query: 1567 KIEKKEKRDSSGGKEEKKHHKSSDKHR 1593
+ K+ + K+E++ K K R
Sbjct: 183 RERKERRERKKERKKERRKKKERKKDR 209
Score = 57.0 bits (136), Expect = 1e-07
Identities = 34/147 (23%), Positives = 71/147 (48%), Gaps = 3/147 (2%)
Query: 1449 KSKEREMDKKDLDKSRERSREREKKDEKDR--KERKRDHSNNDREVPPDLTKRRKEENGT 1506
K ++++ K++ K RER R+ +K K+R KER++ + +R +++
Sbjct: 60 KKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKE 119
Query: 1507 MGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKE 1566
+ +++ E + K++ K + KE+G K +K K KK R+ KE
Sbjct: 120 RKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKK-EEREKKRERNRKE 178
Query: 1567 KIEKKEKRDSSGGKEEKKHHKSSDKHR 1593
+ +++E+++ K+E+K + K R
Sbjct: 179 RKKERERKERRERKKERKKERRKKKER 205
Score = 53.9 bits (128), Expect = 1e-06
Identities = 34/144 (23%), Positives = 63/144 (43%), Gaps = 8/144 (5%)
Query: 1452 EREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSK 1511
+RE ++K + RE+ + +K+ K + +K RE + ++RKE K
Sbjct: 31 QRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKER------EK 84
Query: 1512 HKSESPCESPYPNEKDKEKNKSKSSGK--EKGSDSFKSEKMDKISSGGKKESRHDKEKIE 1569
+ E + +K+K+K + K G+ K K + + +K + K+K
Sbjct: 85 QRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRR 144
Query: 1570 KKEKRDSSGGKEEKKHHKSSDKHR 1593
K+ KR+ GK E+K K + R
Sbjct: 145 KERKREKERGKRERKRKKRKKEER 168
Score = 52.0 bits (123), Expect = 5e-06
Identities = 37/156 (23%), Positives = 70/156 (44%), Gaps = 5/156 (3%)
Query: 1229 KSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKEND-KEKGKEKEKEKKEKTPA 1287
K R++ + G + K + K K+ + K++G+ + K+KKE+
Sbjct: 64 KKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKER 123
Query: 1288 T--TPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTT 1345
+ R + + K K + K EK R +ER K K++E+ KK E+ + E+ K
Sbjct: 124 ERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKER 183
Query: 1346 V--PNAESKSTQEREREKEPSRERDIAKEMKSKENV 1379
E K +++ER K+ R++D + ++ V
Sbjct: 184 ERKERRERKKERKKERRKKKERKKDRKTDRQTDSQV 219
Score = 45.8 bits (107), Expect = 3e-04
Identities = 34/155 (21%), Positives = 67/155 (43%), Gaps = 15/155 (9%)
Query: 1218 KSDESSTEETDKSR----ERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEK 1273
K E +E +K R E+ + K K +G + + + +
Sbjct: 73 KERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRE 132
Query: 1274 GKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKK 1333
K K++ KK++ R K KE+ K ER K R+ +ER K ++ +++ KK
Sbjct: 133 RKRKKRRKKKR--------RKERKREKERGKRER---KRKKRKKEEREKKRERNRKERKK 181
Query: 1334 EEKAKDEKFKTTVPNAESKSTQEREREKEPSRERD 1368
E + K+ + + E + +ER+++++ R+ D
Sbjct: 182 ERERKERRERKKERKKERRKKKERKKDRKTDRQTD 216
Score = 43.1 bits (100), Expect = 0.002
Identities = 32/128 (25%), Positives = 57/128 (44%), Gaps = 11/128 (8%)
Query: 1467 SREREKKDEKDRKERK-RDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNE 1525
S+ +++ + +KER+ R+ +RE K RK E G K K +
Sbjct: 26 SKPCTQRESERKKERREREKRKRERE------KERKRERGKKEKKKRKKRERGKERERKR 79
Query: 1526 KDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKH 1585
K++EK + + KE+ + +K ++ G R K+K E+KE+ + + E+K
Sbjct: 80 KEREKQRKERREKERRKRKKEKKKRERKQRG----RRERKKKKERKERERENKQRRERKR 135
Query: 1586 HKSSDKHR 1593
K K R
Sbjct: 136 KKRRKKKR 143
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 80.5 bits (197), Expect = 1e-14
Identities = 110/427 (25%), Positives = 179/427 (41%), Gaps = 83/427 (19%)
Query: 1225 EETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKE------ 1278
E+ + E S C +K ++K T K + +K E +KEK K K+
Sbjct: 604 EDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQ 663
Query: 1279 ----------KEKKEKTPATTP-------EARVLGKDGK--EKPKEERPNKDE---KARE 1316
KE K+ T E+ L K K + K+++ K++ K R
Sbjct: 664 RSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERN 723
Query: 1317 TKERTPKSDKEKEKFKKEEKAKD--EKFKTTVPNAESKSTQEREREKEPS-------RER 1367
KE K KE EK +EEK KD E+ + + +S+ T E S +E
Sbjct: 724 FKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEI 783
Query: 1368 DIAKEMKS-KENVKGGEKTPVSGSLKSPVPRSDIPEPERE--QKRRKID-THPSPSHSST 1423
DI K+ K KE+ + EK +S + DI + ER+ +K +KI H S
Sbjct: 784 DIEKQEKHIKESKEKPEK-------RSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLD 836
Query: 1424 VKDSLIELKESSAKLYINHTPP------------PLSKSKEREMDKKDLDKSRERSRERE 1471
+ + + ++KE KLY +HT + K+ +RE ++ +D R+ +E+
Sbjct: 837 LSECVDKIKEKD-KLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMD--RKHDKEKP 893
Query: 1472 KKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKD-KEK 1530
+K E+ E K H + D ++ K E G K+K + E D KEK
Sbjct: 894 EK-ERHLAESKEKHLMEKKNKQSDNSEYSKSEKG-----KNKEKD-------RELDKKEK 940
Query: 1531 NKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRD----SSGGKEEKKHH 1586
++ K S S + EK I G K ++H+K K++ +D + GKE+ K
Sbjct: 941 SRDKESINITNSKHIQEEKKSSIVDGNK--AQHEKPLSLKEKTKDEPLKTPDGKEKDKKD 998
Query: 1587 KSSDKHR 1593
K D+++
Sbjct: 999 KDIDRYK 1005
Score = 72.4 bits (176), Expect = 3e-12
Identities = 91/391 (23%), Positives = 168/391 (42%), Gaps = 50/391 (12%)
Query: 1208 PSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVK 1267
P SSS+ S ++S ++ + K ++ S T + + K +K
Sbjct: 569 PESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLK 628
Query: 1268 END-KEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDK 1326
++ K K +EKEK KKE E KE+ KD A+E +R+ + D+
Sbjct: 629 KHKLKHKEREKEKHKKEI----------------EGEKEKYKTKDS-AKEL-QRSVEFDR 670
Query: 1327 E--KEKFKKEEKAKDE--KFKTTVPNAESKSTQERE-REKEPSRERDIAKEMKSKENVKG 1381
E KE F K ++ +D + E KS E+ ++ + ++E+ ++KE KE
Sbjct: 671 EFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKE---- 726
Query: 1382 GEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYIN 1441
E+ + + I + + E R I T +S ++ E S L++
Sbjct: 727 -ERDKIKKESEKSFREEKIKDLKEE--RENIPTDKDSEFTSLGMSAI----EESIGLHL- 778
Query: 1442 HTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRK 1501
+ K + E +K + +S+E+ +R + EKD ++ +R ++++ + +
Sbjct: 779 -----VEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKD 833
Query: 1502 EENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKES 1561
+ + + V K K + S + + KE KSK++ K +D D+ S K +
Sbjct: 834 KLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTD-------DREKSREKMDR 886
Query: 1562 RHDKEKIEKKEKRDSSGGKE--EKKHHKSSD 1590
+HDKEK EK+ S K EKK+ +S +
Sbjct: 887 KHDKEKPEKERHLAESKEKHLMEKKNKQSDN 917
Score = 71.6 bits (174), Expect = 6e-12
Identities = 92/381 (24%), Positives = 158/381 (41%), Gaps = 61/381 (16%)
Query: 1218 KSDESSTEETDKSRERSQCGVKAVNKASSTT-PKGNSSNGNSGSNSNKAVKENDKEKGKE 1276
K ++ E +K +RSQ K + K T K S +K +K KE
Sbjct: 787 KQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKE 846
Query: 1277 KEK------EKKEKTPATTPEARVLGK-DGKEKPKEERPNKDEKARETKERTPKSDKEKE 1329
K+K EK K + + K D +EK +E+ K +K + KER KEK
Sbjct: 847 KDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKH 906
Query: 1330 KFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSG 1389
+K+ K D + ++K +KE SR+++ SK + + + V G
Sbjct: 907 LMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDG 966
Query: 1390 ---------SLKSPVPRSDIPEP---EREQKRRKIDTHPS-PSHSSTVK-DSLIELKESS 1435
SLK + P E+++K + ID + H ++ +SL++LK +
Sbjct: 967 NKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEA 1026
Query: 1436 AKLYINHTPPP---------------LSKSKEREMDKKDLDKSRERSREREKKDEKDRKE 1480
K +P + S ER + KDL+ + + +EK +K+ KE
Sbjct: 1027 DKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKE-KE 1085
Query: 1481 RKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEK 1540
R R+ + + ++ + KE+ +KH +P ES K+KE +SKSS +
Sbjct: 1086 RLRNRNCLELKI------KDKEK------TKH---TPTES-----KNKELTRSKSS---E 1122
Query: 1541 GSDSFKSEKMDKISSGGKKES 1561
+D++ EK K + + +S
Sbjct: 1123 VTDAYTKEKQPKDAVSNRSQS 1143
Score = 61.6 bits (148), Expect = 6e-09
Identities = 97/433 (22%), Positives = 156/433 (36%), Gaps = 72/433 (16%)
Query: 1222 SSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEK---- 1277
SSTE +D+ ++ K ++ + S P+ +SN + + V K+KGK K
Sbjct: 401 SSTESSDEEALQN----KKISTSCSVIPE--TSNSDMQTKKEYVVSGEHKQKGKVKRKLK 454
Query: 1278 -------------EKEKKEKTPATTPEARVLGKDGKEKPKEE-------RPNKDEKARET 1317
EKE KE T T G D EK +EE P D
Sbjct: 455 NQNKNKENQELKQEKEGKENTRITNLTVNT-GLDCSEKTREEGNFRKSFSPKDDTSLHLF 513
Query: 1318 KERTPKSDKEKEKFKKEEKA--KDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKS 1375
T KS K +++ K E KT + S+ + + + + + E + E S
Sbjct: 514 HISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSS 573
Query: 1376 KENVKGGEKTP----------------VSGSLKSPV-PRSDIPEPEREQKRRKIDTHPSP 1418
++ K EK+ + SP SD + +++ + + H
Sbjct: 574 VKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLK 633
Query: 1419 SHSSTVKDSLIELKESSAKLYINHTPPPLSKSKE--REMDKKDLDKSRE----------- 1465
+ E++ K + L +S E RE K++ KS E
Sbjct: 634 HKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHE 693
Query: 1466 ----RSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESP 1521
+ + +K+ KD K K H + +R + K +KE + K K
Sbjct: 694 SLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEEREN 753
Query: 1522 YPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKE 1581
P +KD E S E+ EK I +K+ +H KE EK EKR K+
Sbjct: 754 IPTDKDSEFTSLGMSAIEESIGLHLVEKEIDI----EKQEKHIKESKEKPEKRSQIKEKD 809
Query: 1582 -EKKHHKSSDKHR 1593
EK K+ +K +
Sbjct: 810 IEKMERKTFEKEK 822
Score = 58.9 bits (141), Expect = 4e-08
Identities = 76/363 (20%), Positives = 138/363 (38%), Gaps = 50/363 (13%)
Query: 1207 GPSSSSIGSASKSD--ESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNK 1264
G S + + K+D E S E+ D+ ++ + K + A S NS
Sbjct: 862 GEKSKNTAAIKKTDDREKSREKMDRKHDKEK-PEKERHLAESKEKHLMEKKNKQSDNSEY 920
Query: 1265 AVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKS 1324
+ E K K K++E +KKEK+ + KE + K + ++++
Sbjct: 921 SKSEKGKNKEKDRELDKKEKS----------------RDKESINITNSKHIQEEKKSSIV 964
Query: 1325 DKEKEKFKK----EEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVK 1380
D K + +K +EK KDE KT + K +++++ + +ERD K K+ ++
Sbjct: 965 DGNKAQHEKPLSLKEKTKDEPLKT----PDGKEKDKKDKDIDRYKERD-----KHKDKIQ 1015
Query: 1381 GGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKE-SSAKLY 1439
+ P P+S + K +++ + T + ++ LK+ + +
Sbjct: 1016 INSLLKLKSEADKPKPKSSPASKDTRPKEKRL---VNDDLMQTSFERMLSLKDLEIEQWH 1072
Query: 1440 INHTPPPLSKSKER-------EMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREV 1492
H K KER E+ KD +K++ E + K+ K + + +
Sbjct: 1073 KKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQ 1132
Query: 1493 PPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDK 1552
P D R + T V S D N+S S EK S +S M
Sbjct: 1133 PKDAVSNRSQSVDTKNVMTLGKSS-------FVSDNSLNRSPRSENEKPGLSSRSVSMIS 1185
Query: 1553 ISS 1555
++S
Sbjct: 1186 VAS 1188
Score = 49.3 bits (116), Expect = 3e-05
Identities = 87/423 (20%), Positives = 155/423 (36%), Gaps = 52/423 (12%)
Query: 1205 GGGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNK 1264
GG P ++ D + TEE + +R V + S T + + N S
Sbjct: 251 GGNPFQANKHGERPVDVAETEELELLLKRE---VPLSDDDESYTDSEEAQSVNPSSVDEN 307
Query: 1265 AVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNK--DEK----ARETK 1318
E +K+ E K+ P+ TP L + + +E NK D++ + K
Sbjct: 308 IDSETEKDS---LICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRK 364
Query: 1319 ERTPKSDK-------EKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAK 1371
E P+++K EK + K K+K +K + ++ S +E + K+ S +
Sbjct: 365 ENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIP 424
Query: 1372 EMKS------KENVKGGE---KTPVSGSLKSPVPRSDIPEPEREQKRRK----------- 1411
E + KE V GE K V LK+ + E ++E++ ++
Sbjct: 425 ETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNT 484
Query: 1412 -IDTHPSPSHSSTVKDSLIELKESSAKLY-INHTPPPLSKSKEREMDKKDLDKSRERSRE 1469
+D + S ++S L+ I+ P E L + ++
Sbjct: 485 GLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCL 544
Query: 1470 REKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYP---NEK 1526
E + + N + E P E+ ++ KHK +S + + EK
Sbjct: 545 SPGSSEMSLQPDLVRYDNTESEFLP--------ESSSVKSCKHKEKSKHQKDFHLEFGEK 596
Query: 1527 DKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHH 1586
K K + + +KMDK KK KE+ ++K K++ G KE+ K
Sbjct: 597 SNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTK 656
Query: 1587 KSS 1589
S+
Sbjct: 657 DSA 659
Score = 41.2 bits (95), Expect = 0.008
Identities = 69/350 (19%), Positives = 128/350 (36%), Gaps = 71/350 (20%)
Query: 1182 PENEFHHKDPPPRNAVASVQNGPGGGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAV 1241
PE E H + ++ + S S +K + ++ +KSR++ +
Sbjct: 893 PEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNS 952
Query: 1242 --------------NKASSTTP-------KGNSSNGNSGSNSNKAVKENDKEKGKEKEKE 1280
NKA P K G +K K+ D+ K ++K K+
Sbjct: 953 KHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKD 1012
Query: 1281 K-------KEKTPATTPEARVLGKDGKEKPKEERPNKDEKARET---------------- 1317
K K K+ A P+ + +PKE+R D+ + +
Sbjct: 1013 KIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWH 1072
Query: 1318 ---KERTPKSDKEK--------EKFKKEEKAK----DEKFKTTVPNAESKSTQEREREKE 1362
KE+ + +KE+ K K +EK K + K K + S+ T +EK+
Sbjct: 1073 KKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQ 1132
Query: 1363 PSRERDIAKEMKSKENVKG-GEKTPVSGSLKSPVPRSDIPEP---EREQKRRKIDTHPSP 1418
P + +NV G+ + VS + + PRS+ +P R + +
Sbjct: 1133 PKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDS 1192
Query: 1419 SHSSTVK-------DSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLD 1461
H++ DS L+ S +++ + + P LS +K + +++LD
Sbjct: 1193 CHTTVTTPRPPVEYDSDFMLESSESQMSFSQS-PFLSIAKSPALHERELD 1241
Score = 34.3 bits (77), Expect = 0.99
Identities = 40/181 (22%), Positives = 76/181 (41%), Gaps = 31/181 (17%)
Query: 1217 SKSDESSTEETDKSRERSQCGVKAVNKASS--TTPKGNSSNGNSGSNSNKAVKENDKEKG 1274
+K +S ++D + G K+ +K +S TPK ++ +D K
Sbjct: 7 TKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPK---------------IERSDVSKE 51
Query: 1275 KEKEKEKKEKTPATTPEARVLGKDG--------KEKPKEERPNKDEKARETKERTPKSDK 1326
+++ K K P T +R +D K+K K+E NK P S++
Sbjct: 52 MKEKSSMKRKLPFTISPSRNEERDSDTEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSER 111
Query: 1327 EKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTP 1386
++ + A+D +T PN S++T +++ S + K+ +K N +G +TP
Sbjct: 112 KQMALLMQMTARDNSPDST-PNHPSQTTPAQKKTPSSSSRQ---KDKVNKRNERG--ETP 165
Query: 1387 V 1387
+
Sbjct: 166 L 166
Score = 33.1 bits (74), Expect = 2.2
Identities = 43/187 (22%), Positives = 79/187 (42%), Gaps = 30/187 (16%)
Query: 1257 NSGSNSNKAVKENDKEKGKEKEK-EKKEKTPATTPEARVLGKDGKEKPKEER-------P 1308
NS S+SN K + K K+K KTP E + K+ KEK +R P
Sbjct: 14 NSDSDSNMVEKPYGR---KSKDKIASYSKTPKI--ERSDVSKEMKEKSSMKRKLPFTISP 68
Query: 1309 NKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERD 1368
+++E ER ++KE + KK +K K T V ER ++
Sbjct: 69 SRNE------ERDSDTEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSER-------KQMA 115
Query: 1369 IAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKR--RKIDTHPSPSHSSTVKD 1426
+ +M +++N + TP S +P + R++ + ++ + +P H + ++
Sbjct: 116 LLMQMTARDN--SPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRG 173
Query: 1427 SLIELKE 1433
+ ++KE
Sbjct: 174 DVKQVKE 180
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 80.5 bits (197), Expect = 1e-14
Identities = 110/427 (25%), Positives = 179/427 (41%), Gaps = 83/427 (19%)
Query: 1225 EETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKE------ 1278
E+ + E S C +K ++K T K + +K E +KEK K K+
Sbjct: 627 EDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQ 686
Query: 1279 ----------KEKKEKTPATTP-------EARVLGKDGK--EKPKEERPNKDE---KARE 1316
KE K+ T E+ L K K + K+++ K++ K R
Sbjct: 687 RSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERN 746
Query: 1317 TKERTPKSDKEKEKFKKEEKAKD--EKFKTTVPNAESKSTQEREREKEPS-------RER 1367
KE K KE EK +EEK KD E+ + + +S+ T E S +E
Sbjct: 747 FKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEI 806
Query: 1368 DIAKEMKS-KENVKGGEKTPVSGSLKSPVPRSDIPEPERE--QKRRKID-THPSPSHSST 1423
DI K+ K KE+ + EK +S + DI + ER+ +K +KI H S
Sbjct: 807 DIEKQEKHIKESKEKPEK-------RSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLD 859
Query: 1424 VKDSLIELKESSAKLYINHTPP------------PLSKSKEREMDKKDLDKSRERSRERE 1471
+ + + ++KE KLY +HT + K+ +RE ++ +D R+ +E+
Sbjct: 860 LSECVDKIKEKD-KLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMD--RKHDKEKP 916
Query: 1472 KKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKD-KEK 1530
+K E+ E K H + D ++ K E G K+K + E D KEK
Sbjct: 917 EK-ERHLAESKEKHLMEKKNKQSDNSEYSKSEKG-----KNKEKD-------RELDKKEK 963
Query: 1531 NKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRD----SSGGKEEKKHH 1586
++ K S S + EK I G K ++H+K K++ +D + GKE+ K
Sbjct: 964 SRDKESINITNSKHIQEEKKSSIVDGNK--AQHEKPLSLKEKTKDEPLKTPDGKEKDKKD 1021
Query: 1587 KSSDKHR 1593
K D+++
Sbjct: 1022 KDIDRYK 1028
Score = 72.4 bits (176), Expect = 3e-12
Identities = 91/391 (23%), Positives = 168/391 (42%), Gaps = 50/391 (12%)
Query: 1208 PSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVK 1267
P SSS+ S ++S ++ + K ++ S T + + K +K
Sbjct: 592 PESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLK 651
Query: 1268 END-KEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDK 1326
++ K K +EKEK KKE E KE+ KD A+E +R+ + D+
Sbjct: 652 KHKLKHKEREKEKHKKEI----------------EGEKEKYKTKDS-AKEL-QRSVEFDR 693
Query: 1327 E--KEKFKKEEKAKDE--KFKTTVPNAESKSTQERE-REKEPSRERDIAKEMKSKENVKG 1381
E KE F K ++ +D + E KS E+ ++ + ++E+ ++KE KE
Sbjct: 694 EFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKE---- 749
Query: 1382 GEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYIN 1441
E+ + + I + + E R I T +S ++ E S L++
Sbjct: 750 -ERDKIKKESEKSFREEKIKDLKEE--RENIPTDKDSEFTSLGMSAI----EESIGLHL- 801
Query: 1442 HTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRK 1501
+ K + E +K + +S+E+ +R + EKD ++ +R ++++ + +
Sbjct: 802 -----VEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKD 856
Query: 1502 EENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKES 1561
+ + + V K K + S + + KE KSK++ K +D D+ S K +
Sbjct: 857 KLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTD-------DREKSREKMDR 909
Query: 1562 RHDKEKIEKKEKRDSSGGKE--EKKHHKSSD 1590
+HDKEK EK+ S K EKK+ +S +
Sbjct: 910 KHDKEKPEKERHLAESKEKHLMEKKNKQSDN 940
Score = 71.6 bits (174), Expect = 6e-12
Identities = 92/381 (24%), Positives = 158/381 (41%), Gaps = 61/381 (16%)
Query: 1218 KSDESSTEETDKSRERSQCGVKAVNKASSTT-PKGNSSNGNSGSNSNKAVKENDKEKGKE 1276
K ++ E +K +RSQ K + K T K S +K +K KE
Sbjct: 810 KQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKE 869
Query: 1277 KEK------EKKEKTPATTPEARVLGK-DGKEKPKEERPNKDEKARETKERTPKSDKEKE 1329
K+K EK K + + K D +EK +E+ K +K + KER KEK
Sbjct: 870 KDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKH 929
Query: 1330 KFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSG 1389
+K+ K D + ++K +KE SR+++ SK + + + V G
Sbjct: 930 LMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDG 989
Query: 1390 ---------SLKSPVPRSDIPEP---EREQKRRKIDTHPS-PSHSSTVK-DSLIELKESS 1435
SLK + P E+++K + ID + H ++ +SL++LK +
Sbjct: 990 NKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEA 1049
Query: 1436 AKLYINHTPPP---------------LSKSKEREMDKKDLDKSRERSREREKKDEKDRKE 1480
K +P + S ER + KDL+ + + +EK +K+ KE
Sbjct: 1050 DKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKE-KE 1108
Query: 1481 RKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEK 1540
R R+ + + ++ + KE+ +KH +P ES K+KE +SKSS +
Sbjct: 1109 RLRNRNCLELKI------KDKEK------TKH---TPTES-----KNKELTRSKSS---E 1145
Query: 1541 GSDSFKSEKMDKISSGGKKES 1561
+D++ EK K + + +S
Sbjct: 1146 VTDAYTKEKQPKDAVSNRSQS 1166
Score = 61.6 bits (148), Expect = 6e-09
Identities = 97/433 (22%), Positives = 156/433 (36%), Gaps = 72/433 (16%)
Query: 1222 SSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEK---- 1277
SSTE +D+ ++ K ++ + S P+ +SN + + V K+KGK K
Sbjct: 424 SSTESSDEEALQN----KKISTSCSVIPE--TSNSDMQTKKEYVVSGEHKQKGKVKRKLK 477
Query: 1278 -------------EKEKKEKTPATTPEARVLGKDGKEKPKEE-------RPNKDEKARET 1317
EKE KE T T G D EK +EE P D
Sbjct: 478 NQNKNKENQELKQEKEGKENTRITNLTVNT-GLDCSEKTREEGNFRKSFSPKDDTSLHLF 536
Query: 1318 KERTPKSDKEKEKFKKEEKA--KDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKS 1375
T KS K +++ K E KT + S+ + + + + + E + E S
Sbjct: 537 HISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSS 596
Query: 1376 KENVKGGEKTP----------------VSGSLKSPV-PRSDIPEPEREQKRRKIDTHPSP 1418
++ K EK+ + SP SD + +++ + + H
Sbjct: 597 VKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLK 656
Query: 1419 SHSSTVKDSLIELKESSAKLYINHTPPPLSKSKE--REMDKKDLDKSRE----------- 1465
+ E++ K + L +S E RE K++ KS E
Sbjct: 657 HKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHE 716
Query: 1466 ----RSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESP 1521
+ + +K+ KD K K H + +R + K +KE + K K
Sbjct: 717 SLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEEREN 776
Query: 1522 YPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKE 1581
P +KD E S E+ EK I +K+ +H KE EK EKR K+
Sbjct: 777 IPTDKDSEFTSLGMSAIEESIGLHLVEKEIDI----EKQEKHIKESKEKPEKRSQIKEKD 832
Query: 1582 -EKKHHKSSDKHR 1593
EK K+ +K +
Sbjct: 833 IEKMERKTFEKEK 845
Score = 58.9 bits (141), Expect = 4e-08
Identities = 76/363 (20%), Positives = 138/363 (38%), Gaps = 50/363 (13%)
Query: 1207 GPSSSSIGSASKSD--ESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNK 1264
G S + + K+D E S E+ D+ ++ + K + A S NS
Sbjct: 885 GEKSKNTAAIKKTDDREKSREKMDRKHDKEK-PEKERHLAESKEKHLMEKKNKQSDNSEY 943
Query: 1265 AVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKS 1324
+ E K K K++E +KKEK+ + KE + K + ++++
Sbjct: 944 SKSEKGKNKEKDRELDKKEKS----------------RDKESINITNSKHIQEEKKSSIV 987
Query: 1325 DKEKEKFKK----EEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVK 1380
D K + +K +EK KDE KT + K +++++ + +ERD K K+ ++
Sbjct: 988 DGNKAQHEKPLSLKEKTKDEPLKT----PDGKEKDKKDKDIDRYKERD-----KHKDKIQ 1038
Query: 1381 GGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKE-SSAKLY 1439
+ P P+S + K +++ + T + ++ LK+ + +
Sbjct: 1039 INSLLKLKSEADKPKPKSSPASKDTRPKEKRL---VNDDLMQTSFERMLSLKDLEIEQWH 1095
Query: 1440 INHTPPPLSKSKER-------EMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREV 1492
H K KER E+ KD +K++ E + K+ K + + +
Sbjct: 1096 KKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQ 1155
Query: 1493 PPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDK 1552
P D R + T V S D N+S S EK S +S M
Sbjct: 1156 PKDAVSNRSQSVDTKNVMTLGKSS-------FVSDNSLNRSPRSENEKPGLSSRSVSMIS 1208
Query: 1553 ISS 1555
++S
Sbjct: 1209 VAS 1211
Score = 49.3 bits (116), Expect = 3e-05
Identities = 87/423 (20%), Positives = 155/423 (36%), Gaps = 52/423 (12%)
Query: 1205 GGGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNK 1264
GG P ++ D + TEE + +R V + S T + + N S
Sbjct: 274 GGNPFQANKHGERPVDVAETEELELLLKRE---VPLSDDDESYTDSEEAQSVNPSSVDEN 330
Query: 1265 AVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNK--DEK----ARETK 1318
E +K+ E K+ P+ TP L + + +E NK D++ + K
Sbjct: 331 IDSETEKDS---LICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRK 387
Query: 1319 ERTPKSDK-------EKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAK 1371
E P+++K EK + K K+K +K + ++ S +E + K+ S +
Sbjct: 388 ENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIP 447
Query: 1372 EMKS------KENVKGGE---KTPVSGSLKSPVPRSDIPEPEREQKRRK----------- 1411
E + KE V GE K V LK+ + E ++E++ ++
Sbjct: 448 ETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNT 507
Query: 1412 -IDTHPSPSHSSTVKDSLIELKESSAKLY-INHTPPPLSKSKEREMDKKDLDKSRERSRE 1469
+D + S ++S L+ I+ P E L + ++
Sbjct: 508 GLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCL 567
Query: 1470 REKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYP---NEK 1526
E + + N + E P E+ ++ KHK +S + + EK
Sbjct: 568 SPGSSEMSLQPDLVRYDNTESEFLP--------ESSSVKSCKHKEKSKHQKDFHLEFGEK 619
Query: 1527 DKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHH 1586
K K + + +KMDK KK KE+ ++K K++ G KE+ K
Sbjct: 620 SNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTK 679
Query: 1587 KSS 1589
S+
Sbjct: 680 DSA 682
Score = 41.2 bits (95), Expect = 0.008
Identities = 69/350 (19%), Positives = 128/350 (36%), Gaps = 71/350 (20%)
Query: 1182 PENEFHHKDPPPRNAVASVQNGPGGGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAV 1241
PE E H + ++ + S S +K + ++ +KSR++ +
Sbjct: 916 PEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNS 975
Query: 1242 --------------NKASSTTP-------KGNSSNGNSGSNSNKAVKENDKEKGKEKEKE 1280
NKA P K G +K K+ D+ K ++K K+
Sbjct: 976 KHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKD 1035
Query: 1281 K-------KEKTPATTPEARVLGKDGKEKPKEERPNKDEKARET---------------- 1317
K K K+ A P+ + +PKE+R D+ + +
Sbjct: 1036 KIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWH 1095
Query: 1318 ---KERTPKSDKEK--------EKFKKEEKAK----DEKFKTTVPNAESKSTQEREREKE 1362
KE+ + +KE+ K K +EK K + K K + S+ T +EK+
Sbjct: 1096 KKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQ 1155
Query: 1363 PSRERDIAKEMKSKENVKG-GEKTPVSGSLKSPVPRSDIPEP---EREQKRRKIDTHPSP 1418
P + +NV G+ + VS + + PRS+ +P R + +
Sbjct: 1156 PKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDS 1215
Query: 1419 SHSSTVK-------DSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLD 1461
H++ DS L+ S +++ + + P LS +K + +++LD
Sbjct: 1216 CHTTVTTPRPPVEYDSDFMLESSESQMSFSQS-PFLSIAKSPALHERELD 1264
Score = 32.0 bits (71), Expect = 4.9
Identities = 35/179 (19%), Positives = 66/179 (36%), Gaps = 26/179 (14%)
Query: 1204 PGGGPSSSSIGSASKSDESSTEETDKS-RERSQCGVKAV---------NKASSTTPKGNS 1253
P G S I S SK+ + + K +E+S K + S T
Sbjct: 25 PYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISPSRNEERDSDTDSDPGH 84
Query: 1254 SNGNSGSNSNKAVKENDKEKGKEKEKEKKEK-TPATTPEARVLG--------------KD 1298
++ N G + + +++G EK+K KKE +TP + + G
Sbjct: 85 TSENWGERLISSYRTYSEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMT 144
Query: 1299 GKEKPKEERPNKDEKARETKERTP-KSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQE 1356
++ + PN + +++TP S ++K+K K + + + K +E
Sbjct: 145 ARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKE 203
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 80.5 bits (197), Expect = 1e-14
Identities = 79/392 (20%), Positives = 166/392 (42%), Gaps = 54/392 (13%)
Query: 1220 DESSTEETDKSRERSQCGVKAVNKASSTTPKGN---SSNGNSGSNSNKAVKENDKEKGKE 1276
+ES +E + RS+ V + + S +G+ S + NS + + + + E+ +
Sbjct: 549 NESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRY 608
Query: 1277 KEKEKKEKTPATTPEARVLGKDGKE-KPKEERPNKDEKARETKERTPKSDKEKEK-FKKE 1334
E++ +++ ++ E R +D ++ + +++RP+ + + + + ++ +E+ +
Sbjct: 609 PERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRV 668
Query: 1335 EKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSP 1394
+ +DE+ + E +ERERE+E RER+ +E++ +E + E+
Sbjct: 669 DDRRDERARERDRERERDRERERERERERDREREKERELE-RERARERERER-------- 719
Query: 1395 VPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKERE 1454
E ER+++R + H +D K +ERE
Sbjct: 720 -------EKERDRERDRDRDHDRERERERERDR--------------------EKERERE 752
Query: 1455 MDKKDLDKSRERSREREKKDEKDR-----KERKRDHSNNDREVPPDLTKRRKEE-----N 1504
++++ ++ RER RERE++ E++R KER+R D++ D + ++EE N
Sbjct: 753 REERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRN 812
Query: 1505 GTMGVSKHKSESPCE---SPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKES 1561
G + KS+ SP P + K + + S K+EK +S + +
Sbjct: 813 PRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQE 872
Query: 1562 RHDKEKIEKKEKRDSSGGKEEKKHHKSSDKHR 1593
E R +E++K + R
Sbjct: 873 SRSLSPSHLTEDRQGRWKEEDRKPERKESSRR 904
Score = 79.3 bits (194), Expect = 3e-14
Identities = 75/346 (21%), Positives = 151/346 (43%), Gaps = 34/346 (9%)
Query: 1267 KENDKEKGKEKEKEKKEKTPATTPEARVLGKD-GKEKPKEERPNKDEKARETKERTPKSD 1325
++ ++E+ +E+E+E++ + + R L ++ +E+ +E +D + ++ + +
Sbjct: 679 RDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERE 738
Query: 1326 KEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKE------------- 1372
+E+E+ +++E+ ++ + + E + +ERERE+E +RERD +E
Sbjct: 739 RERERDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRD 798
Query: 1373 -MKSKENVKGGEKTPVSG----SLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSS-TVKD 1426
+ K ++ P G K P P + KRR+ + S +++S K+
Sbjct: 799 DRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKN 858
Query: 1427 SLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHS 1486
L + + + P +++R+ K+ D+ ER + +E++ KE K
Sbjct: 859 EKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKE-KVSSV 917
Query: 1487 NNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDK----------EKNKSKSS 1536
+ RE L R +G H+SE S ++++K +K K
Sbjct: 918 DKQREQTEILESSRMRAQDIIG--HHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDV 975
Query: 1537 GKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEE 1582
G E+G+ SE ++ S K + + EK KK K DS EE
Sbjct: 976 GIERGNIETTSED-GQVFSPKKGQKKKSIEKKRKKSKGDSDISDEE 1020
Score = 70.9 bits (172), Expect = 1e-11
Identities = 85/421 (20%), Positives = 160/421 (38%), Gaps = 63/421 (14%)
Query: 1210 SSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKEN 1269
SS I ++DE E D+ RE + V++ + + +E
Sbjct: 642 SSPIRHQGRNDEL---ERDERREE-----RRVDRVDDRRDERARERDRERERDRERERER 693
Query: 1270 DKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKE 1329
++E+ +E+EKE++ + R + KE+ +E ++D +ER +KE+E
Sbjct: 694 ERERDREREKERELERERARERER---EREKERDRERDRDRDHDRERERERERDREKERE 750
Query: 1330 KFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGG------E 1383
+ ++E + + E+ + E + + RER+KE R+RD + K +++ + +
Sbjct: 751 REREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIRED 810
Query: 1384 KTPVSG----SLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSS----TVKDSLIE----- 1430
+ P G K P P + KRR+ + S +++S K L+
Sbjct: 811 RNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRP 870
Query: 1431 ----------LKESSAKLYINHTPPPLSKSKEREMDKKDL-------DKSRERSREREKK 1473
L E + P K R ++++L DK RE++ E
Sbjct: 871 QESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESS 930
Query: 1474 -----------DEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPY 1522
+DR+ R H N ++ +K++ +G+ + E+ E
Sbjct: 931 RMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQ 990
Query: 1523 ---PNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGG 1579
P + K+K+ K K KG E+ + S KK K+E + G
Sbjct: 991 VFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSK--KKRGPRTPPITTKEELVEMCNG 1048
Query: 1580 K 1580
K
Sbjct: 1049 K 1049
Score = 65.9 bits (159), Expect = 3e-10
Identities = 94/487 (19%), Positives = 179/487 (36%), Gaps = 93/487 (19%)
Query: 1191 PPPRNAVASVQNGPGGGPSSSSIGSASKSDESSTEET-DKSRERSQCGVKAVNKASSTTP 1249
P P ++++S Q S + + D T ++ D+ ER + ++ +
Sbjct: 373 PYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSRE 432
Query: 1250 KGNSSNGNSGSNSNKAVKE-------NDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEK 1302
+ S S ++ +E D +++ + + + + E R +D KE
Sbjct: 433 EREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKES 492
Query: 1303 --PKEERPNKDEKARETKERTPKSDKEKEKFKKEEKA-------KDEKFKTTVPNAESKS 1353
P++ R +D A + ++R + KE EE ++E +T + N
Sbjct: 493 RDPRDSRSTRD--AHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNE 550
Query: 1354 TQEREREKEPSRERDIAKEMKSKENVKGGEKTPV------SGSLKSPVPRSDIPE----P 1403
++ R R R E+ K + +G + + S S RS PE P
Sbjct: 551 SRSEIRNDRMGRSRGRVPELPEKGS-RGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYP 609
Query: 1404 EREQK-------------------RRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTP 1444
ER+ + R+ D PS ++ +E E + ++
Sbjct: 610 ERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDR-- 667
Query: 1445 PPLSKSKEREMDKKDLDKSRERSREREKKDEKDR-------------------------- 1478
+ ++ ++D ++ R+R RERE++ E+DR
Sbjct: 668 --VDDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDR 725
Query: 1479 -KERKRDHS-NNDREVPPDLTKRRKEENGTMGVSKHKS-----ESPCESPYPNEKDKEKN 1531
++R RDH +RE D K R+ E + + E E E+DKE+
Sbjct: 726 ERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERARERDKERE 785
Query: 1532 KSKS-SGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSS-----GGKEEKKH 1585
+ + K+KG D + EK ++I HD+ K +K+ + + S K ++H
Sbjct: 786 RQRDWEDKDKGRDD-RREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREH 844
Query: 1586 HKSSDKH 1592
SD +
Sbjct: 845 SPDSDAY 851
Score = 58.5 bits (140), Expect = 5e-08
Identities = 90/396 (22%), Positives = 153/396 (38%), Gaps = 63/396 (15%)
Query: 1251 GNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEE---R 1307
G S G S++ + E +E+ K K++ T P+ R + KE R
Sbjct: 62 GPSPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVD-TEPQKRNTEESSSPVRKESSRGR 120
Query: 1308 PNKDEKARETKERTPKSDKEKEKFKKEEKAKDE-------KFKTTVPNAESKSTQE---R 1357
+ E + TKERTP+S++E +++ D + ++ K +E
Sbjct: 121 HREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKL 180
Query: 1358 EREKEPSRERDIAKEMKSKENVKG--GEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTH 1415
E+E RE I K+ S E V+ + S KSP +S +K RK
Sbjct: 181 EQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAV 240
Query: 1416 PSPSHSSTVKDSLIELKESSAKLYINHTP-PPLSKSKEREMDKKDLDKSRERSREREK-K 1473
SP + D K + +K TP PP ++ + KK +K + + R EK +
Sbjct: 241 SSP-----LLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTR 295
Query: 1474 DEKDRK---ERKRDHSNNDREVPP------DLTKRRKEENGTMGVS-KHKSESP------ 1517
D KDR ER+R+ + R P ++ R + G S + S SP
Sbjct: 296 DGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTP 355
Query: 1518 --------------CESPYPN------EKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGG 1557
SPYP+ ++ + + +S +EKG + S
Sbjct: 356 SPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTS----QSHD 411
Query: 1558 KKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDKHR 1593
++ R + + ++ ++DS +E ++ SS HR
Sbjct: 412 RRHERREDTRGKRDREKDSREEREYEQDQSSSRDHR 447
Score = 55.1 bits (131), Expect = 5e-07
Identities = 67/369 (18%), Positives = 143/369 (38%), Gaps = 29/369 (7%)
Query: 1226 ETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKT 1285
E + +R + +K + S + S S S+K+ K K K+ ++ +
Sbjct: 181 EQENMEKREEIIIK--KEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTS 238
Query: 1286 PATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTT 1345
++P +L + K + + K + P+ +K+K++ K KD
Sbjct: 239 AVSSP---LLDQQRNSKTNQSK-KKGPRTPSPPPPIPEDIALGKKYKEKYKVKD------ 288
Query: 1346 VPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPER 1405
E K+ ++R ++ R+R+ ++ + G +P+S S +S
Sbjct: 289 --RIEEKTRDGKDRGRDFERQRE-KRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRH 345
Query: 1406 EQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRE 1465
R+ T PSPS+ T+ L SA Y +H+ LS + ++ + RE
Sbjct: 346 SPSPRRKRT-PSPSYQRTLTPPL----RRSASPYPSHS---LSSPQRKQSPPRHRSPMRE 397
Query: 1466 RSREREKKDEK--DRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYP 1523
+ R ++ + DR+ +R+ + R+ D + R+ E H+ + P
Sbjct: 398 KGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDD---REPRD 454
Query: 1524 NEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEK 1583
++ ++ + + S + + + S KESR ++ ++ D +E +
Sbjct: 455 GRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYR-DREGR 513
Query: 1584 KHHKSSDKH 1592
H+ D +
Sbjct: 514 DTHRKEDTY 522
Score = 48.5 bits (114), Expect = 5e-05
Identities = 76/430 (17%), Positives = 159/430 (36%), Gaps = 67/430 (15%)
Query: 1159 RPDLYALAMGYSGQLK-SRKSYMIPENEFHHKDPPPRNAVASVQNG-----PGGGPSSSS 1212
+ +L + G +G L+ S+K +++ +D P R V ++ PG PS S
Sbjct: 1039 KEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTATATTPGSTPSPLS 1098
Query: 1213 --------IGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNK 1264
+ +A+ + +T + + A+ ++S TP ++N + +S++
Sbjct: 1099 SLLPPPPPVATATATTVPATLAATTAAAATSFSTSAITISTSATPTNTTNNTFANEDSHR 1158
Query: 1265 AVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKS 1324
+ + +K +TP T E D + + ++ R+ S
Sbjct: 1159 KC---------HRTRVEKVETPHVTIE------DAQHRKPMDQKRSSSLGSNRSNRSHTS 1203
Query: 1325 DKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEK 1384
+ + + S + R + + R+R + + +E K E
Sbjct: 1204 GRLR--------------------SPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLE- 1242
Query: 1385 TPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSH-SSTVKDSLIELKESSAKLYINHT 1443
++G KS + + EP R + D+ S SS D + + S
Sbjct: 1243 --ITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFD------ 1294
Query: 1444 PPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEE 1503
S+ + +E D+ + D+ RER R ++ E DR K N DR+ + +R +E
Sbjct: 1295 ----SRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRE-RERERER 1349
Query: 1504 NGTMGVSKHKS---ESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKE 1560
+ + + + E ++D+ S+ ++ + E + S +
Sbjct: 1350 DKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDS 1409
Query: 1561 SRHDKEKIEK 1570
DKE+++K
Sbjct: 1410 LALDKERMDK 1419
Score = 40.8 bits (94), Expect = 0.011
Identities = 48/203 (23%), Positives = 89/203 (43%), Gaps = 25/203 (12%)
Query: 1207 GPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGS-NSNKA 1265
G S I + + S + +D+ RS + S+ + SGS +S
Sbjct: 1245 GERKSRIDQLKRGEPSRSTSSDRQDSRSH------SSRRSSPESDRQVHSRSGSFDSRDR 1298
Query: 1266 VKENDK-EKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKS 1324
++E D+ E +E+E+E+++ R KD +R + E+ RE +R
Sbjct: 1299 LQERDRYEHDRERERERRDTRQREWD--RDADKDWPRNRDRDRLRERERERERDKRRDL- 1355
Query: 1325 DKEKEKF------KKEEKAKDEKFKTT----VPNAESKSTQEREREKEPSRERDIA--KE 1372
D+E+E+ + ++ +D F+++ V E+K E ER+ E + +A KE
Sbjct: 1356 DRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKE 1415
Query: 1373 MKSKE--NVKGGEKTPVSGSLKS 1393
K+ +V+G E+T S +S
Sbjct: 1416 RMDKDLGSVQGFEETNKSERTES 1438
Score = 38.9 bits (89), Expect = 0.040
Identities = 48/251 (19%), Positives = 102/251 (40%), Gaps = 19/251 (7%)
Query: 1217 SKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKE 1276
S + S ++ +K R SQ +++ S + G K ++ + +E
Sbjct: 848 SDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEE 907
Query: 1277 KEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKE-- 1334
+E ++K + E + + + + ++ + + RET +R +K+K K +K+
Sbjct: 908 QELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPI 967
Query: 1335 EKAKDE-------KFKTTVPNAESKSTQEREREKEPSRERDIAK--------EMKSKENV 1379
+K K++ +TT + + S ++ +++K ++R +K E +
Sbjct: 968 KKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKK 1027
Query: 1380 KGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKD--SLIELKESSAK 1437
K G +TP + + V + E ++K DT S V D + E + ++
Sbjct: 1028 KRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTATA 1087
Query: 1438 LYINHTPPPLS 1448
TP PLS
Sbjct: 1088 TTPGSTPSPLS 1098
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 80.1 bits (196), Expect = 2e-14
Identities = 85/400 (21%), Positives = 168/400 (42%), Gaps = 53/400 (13%)
Query: 1237 GVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLG 1296
G K NK+ +T K + + A ++E K K K+KKEK E +L
Sbjct: 2 GKKQKNKSEDST-KDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDIL- 59
Query: 1297 KDGKEKPKEERPNKDEKARETKERTPKSDKE---KEKFKKEEKAKDEKF----------- 1342
K+ +E E + K ++ + T +++E K+K KK +K K + F
Sbjct: 60 KELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDK 119
Query: 1343 -----KTTVPNAE--SKSTQEREREKEPSRERDIAKEMKSK---------ENVKGGEKTP 1386
KT P E S S + + K P + + A++ K + K E++
Sbjct: 120 DSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSR 179
Query: 1387 VSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPP 1446
++ S +S + + + QK+ + P P+ S +D A I
Sbjct: 180 INSSGESGDESDEFLQSRKGQKKNQ-KNKPGPNIESGNEDD-------DASFKIKTVAQK 231
Query: 1447 LSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGT 1506
++ KERE K+D +K++ R + +++ E +K++ + + + + + + G
Sbjct: 232 KAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGV 291
Query: 1507 MGVSKHKSESPCESPYPNEKDK-------------EKNKSKSSGKEKGSDSFKSEKMDKI 1553
+ S+ K+E+P + NE DK EK K K G K + E + K+
Sbjct: 292 IPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKL 351
Query: 1554 SSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDKHR 1593
+++ R ++E+I++ E+ ++ +EE+ + ++ +
Sbjct: 352 KEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKK 391
Score = 79.0 bits (193), Expect = 4e-14
Identities = 99/432 (22%), Positives = 168/432 (38%), Gaps = 61/432 (14%)
Query: 1199 SVQNGPGGGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNS 1258
++++G +S I + ++ E K R+ + ++ + K G
Sbjct: 211 NIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKL-KEKEELETGKKDQSKQ 269
Query: 1259 GSNSNKAVKENDKEK-----GKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEK 1313
+ K +E K K G E+K +TP + K K+K K+++ K+EK
Sbjct: 270 KESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDK-KKKKGEKEEK 328
Query: 1314 ARETKERTPKSD---------KEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPS 1364
+E K+ K+ K KE+ +++++ ++E+ K + E+K +E ER ++
Sbjct: 329 EKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIK-RLEELEAK-RKEEERLEQEK 386
Query: 1365 RERDIAKEMKSKENVKGGEKTPVSGSLKS----------------PVPRSDIPEPER--- 1405
RER KE + KE +K K ++ VP D +R
Sbjct: 387 RERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIY 446
Query: 1406 -EQKRRKIDTHPSPSHSSTVKDSL-----IELKESSAKLYINHTPPPLSKSKEREMDKKD 1459
++KR+KI P S V +S+ +E+ E TPPP+ +E + +
Sbjct: 447 EDKKRKKI---PQQLESKEVSESMELCAAVEVMEQGVP-EKEETPPPVEPEEEEDTEDAG 502
Query: 1460 LD------KSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHK 1513
LD E + K + KE + + E D + +EE G S+
Sbjct: 503 LDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEED--EESEEEEEEEGESEGS 560
Query: 1514 SESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEK--IEKK 1571
+ +EKD K K KE SDS + D K+E +DK K IEK+
Sbjct: 561 EGDEEDEKVSDEKDSGKTLDKKPSKEMSSDS----EYDSDDDRTKEERAYDKAKRRIEKR 616
Query: 1572 EKRDSSGGKEEK 1583
S EK
Sbjct: 617 RLEHSKNVNTEK 628
Score = 77.0 bits (188), Expect = 1e-13
Identities = 89/419 (21%), Positives = 172/419 (41%), Gaps = 49/419 (11%)
Query: 1214 GSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEK 1273
G D++ +EE + +S+ K + S + + N KA K N K
Sbjct: 103 GKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWD 162
Query: 1274 GKEKEKEKKEKTPATT-----------PEARVLGKDGKEKPKEERP-------NKDEKAR 1315
G E++++ +K + + + + G++K ++ +P N+D+ A
Sbjct: 163 GSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDAS 222
Query: 1316 ---ETKERTPKSDKEKEKFKK-EEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAK 1371
+T + KE+E+ K+ EEKAK K K E T ++++ K+ +R +
Sbjct: 223 FKIKTVAQKKAEKKERERKKRDEEKAKLRKLK----EKEELETGKKDQSKQKESQRKFEE 278
Query: 1372 E-MKSKENVKGGEKTPVSGSLKSPVPRSDIPE------------PEREQKRRKIDTHPSP 1418
E +KSK V G ++P D E E+E+K ++ PS
Sbjct: 279 ETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSK 338
Query: 1419 SHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDR 1478
+ ++++L +LKE + + + +E E +K+ ++ + RER+K+ EK+R
Sbjct: 339 ATVKAMQEALAKLKEEEER-QKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKER 397
Query: 1479 KERKRDH------SNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNK 1532
KER + S + + T + + G S K P + P +K ++K
Sbjct: 398 KERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPS--KDSLPKKRPIYEDKKRKKIP 455
Query: 1533 SKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDK 1591
+ KE S+S + ++ G E +E +E+ D+ + +SD+
Sbjct: 456 QQLESKEV-SESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDE 513
Score = 73.6 bits (179), Expect = 1e-12
Identities = 86/392 (21%), Positives = 169/392 (43%), Gaps = 41/392 (10%)
Query: 1222 SSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEK 1281
SS E D+S E Q K K P N +GN +++ +K ++K ++KE+E+
Sbjct: 182 SSGESGDESDEFLQSR-KGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERER 240
Query: 1282 KEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKF---KKEEKAK 1338
K++ ++ K+ E K+++ + E R+ +E T KS + EEKA+
Sbjct: 241 KKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAE 300
Query: 1339 -----------DEKFKTTVPNAESKSTQEREREKEPSR------ERDIAKEMKSKENVKG 1381
D+K K K +E+E++K PS+ + +AK + +E K
Sbjct: 301 TPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKR 360
Query: 1382 GEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYIN 1441
E+ + + R + E+E++ RK + L+ + A+
Sbjct: 361 EEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAE 420
Query: 1442 HTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRK 1501
T L +++ E+ KD S +++ +D+K +K +EV +
Sbjct: 421 ATLK-LLQAQGVEVPSKD-------SLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAA 472
Query: 1502 EENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGK--- 1558
E GV + + E+P P E ++E++ ++ +G + E+ +K+ G K
Sbjct: 473 VEVMEQGVPEKE-----ETPPPVEPEEEED-TEDAGLDDWEAMASDEETEKVE-GNKVHI 525
Query: 1559 --KESRHDKEKIEKKEKRDSSGGKEEKKHHKS 1588
KE+ ++E+ E++E+ D +EE++ +S
Sbjct: 526 EVKENPEEEEEEEEEEEEDEESEEEEEEEGES 557
>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
containing B [Homo sapiens]
Length = 546
Score = 78.2 bits (191), Expect = 6e-14
Identities = 84/378 (22%), Positives = 157/378 (41%), Gaps = 79/378 (20%)
Query: 1218 KSDESSTEETDK--SRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGK 1275
K + EE D+ R RS+ ++++ S + S+ G S+ +E ++EK +
Sbjct: 242 KDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKER 301
Query: 1276 EK-EKEKKEKTPATTPEARV-LGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKK 1333
++ E+E KE+ + G + + ER ++R+ K D+E+EK +
Sbjct: 302 QRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENE 361
Query: 1334 EEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKS 1393
+ +D + + + ERE+E+E SRER +KE +S+ V+
Sbjct: 362 RGRRRDRDY-------DKERGNEREKERERSRER--SKEQRSRGEVE------------- 399
Query: 1394 PVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKER 1453
E++ K K D H +DS E K S ++ + S+S+ R
Sbjct: 400 ----------EKKHKEDKDDRR----HRDDKRDSKKEKKHSRSR---SRERKHRSRSRSR 442
Query: 1454 EMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHK 1513
K+ SR RS+E+ K + + KE+ S + + D ++ SK +
Sbjct: 443 NAGKR----SRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEK----------SKKR 488
Query: 1514 SESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEK 1573
SP KEK++ +S KE+ S+ D + +HD+ + + E+
Sbjct: 489 EHSP---------SKEKSRKRSRSKERSHKRDHSDSKD-------QSDKHDRRRSQSIEQ 532
Query: 1574 RDSSGGKEEKKHHKSSDK 1591
+ ++K HK+ D+
Sbjct: 533 ------ESQEKQHKNKDE 544
Score = 72.0 bits (175), Expect = 4e-12
Identities = 72/310 (23%), Positives = 124/310 (40%), Gaps = 41/310 (13%)
Query: 1293 RVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESK 1352
R + KDGKE +E D + R+P+ + + +++ +
Sbjct: 238 RKIKKDGKEGAEEI----DRHVERRRSRSPRRSLSPRRSPRRSRSRSHHRE-----GHGS 288
Query: 1353 STQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKI 1412
S+ +RE E+E R+R + +E K +E + ++ G ER + R +
Sbjct: 289 SSFDRELEREKERQR-LEREAKEREKERRRSRSIDRGL-------------ERRRSRSR- 333
Query: 1413 DTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDK-KDLDKSRERSRERE 1471
+ H S S S K + K KER ++ K+ ++SRERS+E+
Sbjct: 334 ERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQR 393
Query: 1472 KKDEKDRKERKRDHSNN-DREVPPDLTKRRKEENGTMGVSKHKSESPCE----------- 1519
+ E + K+ K D + R+ D K +K KH+S S
Sbjct: 394 SRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSK 453
Query: 1520 ---SPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDS 1576
S + NE ++ NK SG + +DS + K + S +K + + K E+ KRD
Sbjct: 454 EKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSK-ERSHKRDH 512
Query: 1577 SGGKEEKKHH 1586
S K++ H
Sbjct: 513 SDSKDQSDKH 522
Score = 67.0 bits (162), Expect = 1e-10
Identities = 84/397 (21%), Positives = 160/397 (40%), Gaps = 51/397 (12%)
Query: 1106 KASVHCLET-GEYTHIRNILIVLTKILPWYPKV-----LNLGQALERRVHKICQEEKEKR 1159
KA C+ T GE +R+ L L +P++ N+ Q ++ R KI ++ KE
Sbjct: 191 KAGGGCVMTIGEM--LRSFLTKLEWFSTLFPRIPVPVQKNIDQQIKTRPRKIKKDGKEGA 248
Query: 1160 PDLYALAMGYSGQLKSRKSYMIPENEFHHKDPPPRNAVASVQNGPGGGPSSSSIGSASKS 1219
++ + R+ P + P R+ S + G G SS +
Sbjct: 249 EEI--------DRHVERRRSRSPRRSLSPRRSPRRSRSRS-HHREGHGSSSFDRELEREK 299
Query: 1220 DESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNS-NKAVKENDKEKGKEKE 1278
+ E K RE+ + +++++ + S S S ++ D+++ +EKE
Sbjct: 300 ERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKE 359
Query: 1279 KEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAK 1338
E+ + + R G E+ KE R E+++E + R +K+ ++ K + + +
Sbjct: 360 NERGRRRDRDYDKER-----GNEREKE-RERSRERSKEQRSRGEVEEKKHKEDKDDRRHR 413
Query: 1339 DEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRS 1398
D+K + S+S + + SR R+ K +S+ K + S + RS
Sbjct: 414 DDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRS 473
Query: 1399 DIP-EPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDK 1457
+ +K +K + PS KE S K S+SKER K
Sbjct: 474 GSQGRTDSVEKSKKREHSPS--------------KEKSRK---------RSRSKERS-HK 509
Query: 1458 KDLDKSRERS--REREKKDEKDRKERKRDHSNNDREV 1492
+D S+++S +R + +++ +++ H N D V
Sbjct: 510 RDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDETV 546
Score = 61.2 bits (147), Expect = 8e-09
Identities = 64/283 (22%), Positives = 111/283 (39%), Gaps = 27/283 (9%)
Query: 1328 KEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPV 1387
++ ++ K + K K + + ER + S R ++ + +
Sbjct: 226 QKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREG 285
Query: 1388 SGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPL 1447
GS S R E ER++ R+ S D +E + S ++
Sbjct: 286 HGS--SSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSR--------ER 335
Query: 1448 SKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEE---N 1504
+S+ R D+K + R+R RE+E + + R N+RE + ++ R +E
Sbjct: 336 HRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSR 395
Query: 1505 GTMGVSKHKSESPCESPYPNEKD--KEKNKSKSSGKE-KGSDSFKSEKMDKISSGGKKE- 1560
G + KHK + +++D KEK S+S +E K +S K S KE
Sbjct: 396 GEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEK 455
Query: 1561 -SRHDKEKIEKKEKRDSSGGK---------EEKKHHKSSDKHR 1593
S+H E EK KR SG + ++++H S +K R
Sbjct: 456 SSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSR 498
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 77.8 bits (190), Expect = 8e-14
Identities = 88/385 (22%), Positives = 159/385 (41%), Gaps = 30/385 (7%)
Query: 1225 EETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEK 1284
E +K + +K K S T + S S + A K+ K K +++ +K
Sbjct: 581 ESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKK 640
Query: 1285 TPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEK--- 1341
PE + K+ KEKPK+E K++K KE PK ++ K++ KKE K +++K
Sbjct: 641 ETKVKPEDK---KEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPK 697
Query: 1342 ---FKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRS 1398
K T P K ++ E+++ E++ KE+K TP+S + K +
Sbjct: 698 KEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKP 757
Query: 1399 DIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKES---SAKLYINHTPPPLSKSKEREM 1455
+P+ E K+ + P +K E K + +A + T + +
Sbjct: 758 KVPKKEESVKKDSV-AAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAA 816
Query: 1456 DKKDLDKSRERSREREKKD-EKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKS 1514
+ ERS +D KD +E K + + +++ P L EE K K
Sbjct: 817 IGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEE-------KLKE 869
Query: 1515 ESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKS----EKMDKISSGGKKESRHDKEKIEK 1570
P E+ Y +K++E K + ++G + + E+ + +K+ D EK E
Sbjct: 870 TEPVEA-YVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFED 928
Query: 1571 K----EKRDSSGGKEEKKHHKSSDK 1591
+ E+ +G EEK + +++
Sbjct: 929 EGAGFEESSETGDYEEKAETEEAEE 953
Score = 68.9 bits (167), Expect = 4e-11
Identities = 104/449 (23%), Positives = 171/449 (38%), Gaps = 57/449 (12%)
Query: 1173 LKSRKSYMIPENEFHHKDPP-PRNAVASVQNGPGGGPSSSSIGSASKSDESSTEETDKSR 1231
+K+ + E E K+ P P A + + P ++ + K + E+ + +
Sbjct: 594 IKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEK 653
Query: 1232 ERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPE 1291
E+ + K V K TP + KE KE+ KE +KE K++TP +
Sbjct: 654 EKPK---KEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVK 710
Query: 1292 ARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAES 1351
V ++ KE KEE+ K E ++ PK D +K E K K VP E
Sbjct: 711 KEVKKEEKKEVKKEEKEPKKEI-----KKLPK-DAKKSSTPLSEAKKPAALKPKVPKKEE 764
Query: 1352 ---KSTQEREREKEPSRERDIAKEMKSKENVKGGEKT--------------PVSGSLKSP 1394
K + + KE + + I KE K+ E V T + + +
Sbjct: 765 SVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELE 824
Query: 1395 VPRSDIPEPE------REQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLS 1448
RS + PE E K ++D + +K L EL E KL
Sbjct: 825 AERSLMSSPEDLTKDFEELKAEEVDV------TKDIKPQL-ELIEDEEKLKETEPVEAYV 877
Query: 1449 KSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKE-----E 1503
KERE+ K + E E + E ++ + + +++ D+ K E E
Sbjct: 878 IQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPV--EKQGVDDIEKFEDEGAGFEE 935
Query: 1504 NGTMGVSKHKSESPCESPYPNEKDKEK---NKSKSSGKEKG------SDSFKSEKMDKIS 1554
+ G + K+E+ E+ P E +E + SK S E +D++ EK + ++
Sbjct: 936 SSETGDYEEKAETE-EAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVA 994
Query: 1555 SGGKKESRHDKEKIEKKEKRDSSGGKEEK 1583
SG + E IEK E S +E+
Sbjct: 995 SGDDRAEEDMDEAIEKGEAEQSEEEADEE 1023
Score = 61.6 bits (148), Expect = 6e-09
Identities = 97/427 (22%), Positives = 183/427 (42%), Gaps = 73/427 (17%)
Query: 1217 SKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKE 1276
+++ S TE+ S+E V + +T K ++ + K VK DK++ KE
Sbjct: 596 TETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETK-VKPEDKKEEKE 654
Query: 1277 KEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKD-------EKARE-----TKERTPKS 1324
K K++ K TP + +EKPK+E K+ E+ +E KE PK
Sbjct: 655 KPKKEVAKKEDKTPIKK------EEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKE 708
Query: 1325 DK------EKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKS--K 1376
K EK++ KKEEK ++ K +A+ ST E +K + + + K+ +S K
Sbjct: 709 VKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKK 768
Query: 1377 ENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVK-------DSLI 1429
++V G+ P + I ++E K + + ++T ++
Sbjct: 769 DSVAAGK----------PKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIG 818
Query: 1430 ELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREK-KDEKDRKERKRDHS-- 1486
KE A+ + +P L+K E E+ +++D +++ + E +DE+ KE + +
Sbjct: 819 PAKELEAERSLMSSPEDLTKDFE-ELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYV 877
Query: 1487 -NNDREVPPDLTKRRKEENGTMGVSKHKSESPCESP----YPNEK----DKEKNKSKSSG 1537
+REV + E+ G++ + E CE P EK D EK + + +G
Sbjct: 878 IQKEREV-----TKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAG 932
Query: 1538 KEKGSDS------FKSEKMDKISSGGKKE-----SRHDKEKIEKKEKRDSSGGKEEKKHH 1586
E+ S++ ++E+ ++ G++ S+H + E+ K ++ EK+
Sbjct: 933 FEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRES 992
Query: 1587 KSSDKHR 1593
+S R
Sbjct: 993 VASGDDR 999
Score = 61.2 bits (147), Expect = 8e-09
Identities = 71/293 (24%), Positives = 121/293 (41%), Gaps = 32/293 (10%)
Query: 1248 TPKGNSSNGNSGSNSNKAVKENDKE-KGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEE 1306
TP + ++S +++K K K KE KE+TP T V K K + KE+
Sbjct: 527 TPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHV-EKPPKVESKEK 585
Query: 1307 RPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRE 1366
K +K +T+ + ++KE ++ K E + + + K+ +E+ +KE +
Sbjct: 586 VMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVK 645
Query: 1367 RDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKD 1426
+ KE K K + +K K+P+ + + P+ E +K K K+
Sbjct: 646 PEDKKEEKEKPKKEVAKKED-----KTPIKKEEKPKKEEVKKEVK-------------KE 687
Query: 1427 SLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHS 1486
E K+ K TPP K + ++ +KK++ K + ++ KK KD K+
Sbjct: 688 IKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSS---- 743
Query: 1487 NNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKE 1539
L++ +K V K K ES + K KEK K K KE
Sbjct: 744 -------TPLSEAKKPAALKPKVPK-KEESVKKDSVAAGKPKEKGKIKVIKKE 788
Score = 52.8 bits (125), Expect = 3e-06
Identities = 52/209 (24%), Positives = 94/209 (44%), Gaps = 15/209 (7%)
Query: 1387 VSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLY-INHTP- 1444
++G + +PV + + +R R + P S +V+ E KE + ++ +NH
Sbjct: 521 LTGQVPTPVVKQTKLK-QRADSRESLKPAAKPLPSKSVRK---ESKEETPEVTKVNHVEK 576
Query: 1445 PPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEEN 1504
PP +SKE+ M KKD E +K+ ++E + + D+ + +E
Sbjct: 577 PPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEK 636
Query: 1505 GTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSE--KMDKISSGGKKESR 1562
+K K P +++KEK K + + KE + K E K +++ KKE +
Sbjct: 637 TVKKETKVK-------PEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIK 689
Query: 1563 HDKEKIEKKEKRDSSGGKEEKKHHKSSDK 1591
+++K KKE + + KE KK K +K
Sbjct: 690 KEEKKEPKKEVKKETPPKEVKKEVKKEEK 718
Score = 48.5 bits (114), Expect = 5e-05
Identities = 50/202 (24%), Positives = 86/202 (42%), Gaps = 29/202 (14%)
Query: 1208 PSSSSIGSASKSDESSTEETDKS-------------RERSQCGVKAVNKASSTTPKGNSS 1254
PS ++ + DES T TDK+ ++RS S P+ +
Sbjct: 2170 PSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHP--DVSMVDPEALAI 2227
Query: 1255 NGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKA 1314
N G KA+K++ KEK K K+ K K+ + ++ DGK KP P K
Sbjct: 2228 EQNLG----KALKKDLKEKTKTKKPGTKTKSSSPVKKS-----DGKSKPLAASP-KPAGL 2277
Query: 1315 RETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMK 1374
+E+ ++ + K+K E+ AK TT P ++ +E+++E + + +K K
Sbjct: 2278 KESSDKVSRVASPKKKESVEKAAKP----TTTPEVKAARGEEKDKETKNAANASASKSAK 2333
Query: 1375 SKENVKGGEKTPVSGSLKSPVP 1396
+ G KT S ++ +P
Sbjct: 2334 TATAGPGTTKTTKSSAVPPGLP 2355
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 77.4 bits (189), Expect = 1e-13
Identities = 94/415 (22%), Positives = 154/415 (37%), Gaps = 45/415 (10%)
Query: 1189 KDPPPRNAVASVQNG--PG-----GGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAV 1241
KD PR ++G PG G PS S+ +S + SR RS+C
Sbjct: 1428 KDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTP--SRGRSECDSSPE 1485
Query: 1242 NKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKE 1301
KA TP+ S + +S +NK + + G E + +KT A TP + + G
Sbjct: 1486 PKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVD--QKTVARTPLGQ-RSRSGSS 1542
Query: 1302 KPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREK 1361
+ + +P+ + R + +P S K K + + P +SKS R +
Sbjct: 1543 QELDVKPSASPQERSESDSSPDS-----KAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSR 1597
Query: 1362 EPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHS 1421
S K + G + +P K+P PR+ +P R K PSP S
Sbjct: 1598 SGSSPEVKDKPRAAPRAQSGSDSSP---EPKAPAPRA-LPRRSRSGSSSK-GRGPSPEGS 1652
Query: 1422 STVKDSLIE-LKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKE 1480
S+ + S K +A+ +P P K+K R ++ +S S E +K R+
Sbjct: 1653 SSTESSPEHPPKSRTARRGSRSSPEP--KTKSRTPPRR---RSSRSSPELTRKARLSRRS 1707
Query: 1481 RKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEK 1540
R S R P +H+ SP P EK + + +S+ +
Sbjct: 1708 RSASSSPETRSRTP---------------PRHRRSPSVSSPEPAEKSRSSRRRRSASSPR 1752
Query: 1541 GSDSFKSEKMDKISSGG--KKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDKHR 1593
+ + + G + SR +EK +RD SG + + + R
Sbjct: 1753 TKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSR 1807
Score = 61.6 bits (148), Expect = 6e-09
Identities = 88/421 (20%), Positives = 155/421 (36%), Gaps = 36/421 (8%)
Query: 1192 PPRNAVASVQNGPGGGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKG 1251
PP A + P P S+S+S S + T SR S +S +PK
Sbjct: 393 PPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHAS---------SSPESPKP 443
Query: 1252 NSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARV-------LGKDGKEKPK 1304
+ G S++ + + K + + K++K+ + TP R+ K G+ + +
Sbjct: 444 APAPG-----SHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSR 498
Query: 1305 EERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPS 1364
++R + R +S + + + ++ + + S++TQ R R +
Sbjct: 499 TPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSAR 558
Query: 1365 RERDIAKEMKSKENVKGGEKTPVS-GSLKSPVP---RSDIPEPEREQKRRKIDTHPSPSH 1420
R R ++ ++ + +TP G +S P RS P R + R + S
Sbjct: 559 RGRSHSRSPATRGRSRS--RTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSR 616
Query: 1421 SSTVKDSLIELKESSAKLYINHTPPPLS-KSKEREMDKKDLDKSR---ERSREREKKDEK 1476
S T + + + +P S +S+ R ++ +SR R R R + +
Sbjct: 617 SRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPAR 676
Query: 1477 DRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSES--PCESPYPNEKDKEKNKSK 1534
R R R + R T RR V + +S S P + KNKS+
Sbjct: 677 -RSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSR 735
Query: 1535 SSGKEKGSDSFKSEKMDKISSGGKK--ESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDKH 1592
+S + S+S K +ISS + S K K +R SG K +
Sbjct: 736 TSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPR 795
Query: 1593 R 1593
R
Sbjct: 796 R 796
Score = 57.4 bits (137), Expect = 1e-07
Identities = 67/305 (21%), Positives = 116/305 (38%), Gaps = 41/305 (13%)
Query: 1248 TPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEER 1307
TP+G+ +NG N + V+ E+ K +E+ + A + R
Sbjct: 9 TPRGSGTNGYVQRNLS-LVRGRRGERPDYKGEEELRRLEAALVK---------------R 52
Query: 1308 PNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAE----SKSTQEREREKEP 1363
PN D E K R E E+ +E+ ++++ + V K +E+ P
Sbjct: 53 PNPDILDHERKRRVELRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEKDVNPGGKEETP 112
Query: 1364 SRERDIAKEMKSKE-NVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSS 1422
+ + + + E N K E+ + + +P+R + K P S
Sbjct: 113 GQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPYS 172
Query: 1423 TVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERK 1482
V++S SS++ +P P K K+++ D+ +S RER KK K +K R
Sbjct: 173 LVRES------SSSR-----SPTPKQKKKKKKKDRGRRSESSSPRRER-KKSSKKKKHRS 220
Query: 1483 RDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGS 1542
S + P +RK SK K S P K + ++S S+ S
Sbjct: 221 ESESKKRKHRSPTPKSKRK--------SKDKKRKRSRSTTPAPKSRRAHRSTSADSASSS 272
Query: 1543 DSFKS 1547
D+ +S
Sbjct: 273 DTSRS 277
Score = 57.4 bits (137), Expect = 1e-07
Identities = 91/401 (22%), Positives = 155/401 (38%), Gaps = 61/401 (15%)
Query: 1215 SASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKG 1274
S S D SS + ++RE Q + PK S S S+ + K+ K+K
Sbjct: 142 SDSYVDGSSFDPQRRAREAKQ--------PAPEPPKPYSLVRESSSSRSPTPKQ--KKKK 191
Query: 1275 KEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKE 1334
K+K++ ++ ++ + E + K K+ R + K R+ + TPKS K K K KK
Sbjct: 192 KKKDRGRRSESSSPRRE-----RKKSSKKKKHRSESESKKRKHRSPTPKS-KRKSKDKKR 245
Query: 1335 EKAKD--------EKFKTTVPNAESKSTQEREREKEPSRERD---IAKEMKSKENVKGGE 1383
++++ ++T ++ S S R R + + + +A S + + GE
Sbjct: 246 KRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGE 305
Query: 1384 -KTPVSGSLKSPVPRSDIPEPEREQ-----------KRRKIDTHPSPS--HSSTVKDSLI 1429
P S + R PE +Q K+ K T PSPS SST
Sbjct: 306 GDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGP---- 361
Query: 1430 ELKESSAKLYINH--TPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSN 1487
E + L H +P PL+ + + ++ ++ E S R++ K ++ + S+
Sbjct: 362 EPPAPTPLLAERHGGSPQPLATT---PLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSS 418
Query: 1488 NDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKS 1547
P TK VS+H S SP ESP P + SS K ++
Sbjct: 419 ESSPPSPQPTK----------VSRHASSSP-ESPKPAPAPGSHREISSSPTSKNRSHGRA 467
Query: 1548 EKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKS 1588
++ S + + K R S ++ H +S
Sbjct: 468 KRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRS 508
Score = 55.5 bits (132), Expect = 4e-07
Identities = 75/388 (19%), Positives = 132/388 (34%), Gaps = 30/388 (7%)
Query: 1192 PPRNAVASVQNGPGGGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVN-KASSTTPK 1250
P R+ S G G P SS S ESS E KSR + + K S TP
Sbjct: 1633 PRRSRSGSSSKGRGPSPEGSS------STESSPEHPPKSRTARRGSRSSPEPKTKSRTPP 1686
Query: 1251 GNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNK 1310
S+ +S + KA + + P V + EK + R +
Sbjct: 1687 RRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRR 1746
Query: 1311 DEKARETKERTPK----SDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRE 1366
+ TK + + S K + + +++ EK +TT S S+Q R ++ SR
Sbjct: 1747 SASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRS 1806
Query: 1367 RDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKD 1426
R + +GG SG R + ++R + T P+ S +
Sbjct: 1807 RSRVTRRR-----RGG-----SGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRT 1856
Query: 1427 SLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHS 1486
S K S ++ S + R + SR RSR R + R + +
Sbjct: 1857 SPAPWKRSRSRA---------SPATHRRSRSRTPLISRRRSRSRTSPVSRRRSRSRTSVT 1907
Query: 1487 NNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFK 1546
RR+ + T V++ +S S + + + ++ + + +
Sbjct: 1908 RRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRRSRSRTPPVTRRRSRSRTPPVTR 1967
Query: 1547 SEKMDKISSGGKKESRHDKEKIEKKEKR 1574
+ S ++ SR + ++ R
Sbjct: 1968 RRSRSRTSPITRRRSRSRTSPVTRRRSR 1995
Score = 55.1 bits (131), Expect = 5e-07
Identities = 92/431 (21%), Positives = 148/431 (34%), Gaps = 61/431 (14%)
Query: 1170 SGQLKSRKSYMIPENEFHHKDPPPRNAVASVQNGPGGGPSSSSIGSASKSDESSTEETDK 1229
SG+ +SR P + P S P S + ++ S + +
Sbjct: 644 SGRSRSRT----PARRGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRR 699
Query: 1230 SRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATT 1289
R RS+ V+ ++ S TP+ +G+S NK+ + + + + +K+ ++
Sbjct: 700 GRSRSRSLVRR-GRSHSRTPQRRGRSGSSSERKNKS--RTSQRRSRSNSSPEMKKSRISS 756
Query: 1290 PEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNA 1349
+R L P K+R + R+ K K + + + ++ P A
Sbjct: 757 RRSRSLSS----------PRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKA 806
Query: 1350 ESKSTQERER----------EKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSD 1399
+S++ R R K PSR+ + K VK G P GS+ SP
Sbjct: 807 KSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPK--VKSG-TPPRQGSITSPQANEQ 863
Query: 1400 IPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKD 1459
P Q+R ++ P P S S SS + TPP S S
Sbjct: 864 SVTP---QRRSCFESSPDPELKSRT-PSRHSCSGSSPPRVKSSTPPRQSPS--------- 910
Query: 1460 LDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCE 1519
RS + K + R+R HS + P +T R + +S SPC
Sbjct: 911 ------RSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPR-------RSRSVSPCS 957
Query: 1520 SPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGG 1579
N + + + SG K E + S G S + K K + SG
Sbjct: 958 ----NVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSG-SISPYPKVKAQTPPGPSLSGS 1012
Query: 1580 KEEKKHHKSSD 1590
K KS D
Sbjct: 1013 KSPCPQEKSKD 1023
Score = 50.1 bits (118), Expect = 2e-05
Identities = 72/384 (18%), Positives = 131/384 (34%), Gaps = 21/384 (5%)
Query: 1204 PGGGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSN 1263
P P S +S ++ T + R RS + V+ S +P+ S +G+S +
Sbjct: 1549 PSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPE-VDSKSRLSPR-RSRSGSSPEVKD 1606
Query: 1264 KAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPK 1323
K + G + E K P P G K + P + E PK
Sbjct: 1607 KPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPS--PEGSSSTESSPEHPPK 1664
Query: 1324 SDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRE-RDIAKEMKSKENVKGG 1382
S + + + K K +T S+S+ E R+ SR R + +++
Sbjct: 1665 SRTARRGSRSSPEPKT-KSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPR 1723
Query: 1383 EKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINH 1442
+ S S P +S R + T S + K ++ S ++
Sbjct: 1724 HRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTR 1783
Query: 1443 TPPPLSKSKEREMDKKDLDKSRERSREREKK--------DEKDRKERKRDHSNNDR---E 1491
T +S + + +SR RSR ++ R+E R S R
Sbjct: 1784 TTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRSR 1843
Query: 1492 VPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMD 1551
PP KR + + +S + SP + + + + S + + S S +
Sbjct: 1844 TPPTSRKRSRSRTSPAPWKRSRSRA---SPATHRRSRSRTPLISRRRSRSRTSPVSRRRS 1900
Query: 1552 KI-SSGGKKESRHDKEKIEKKEKR 1574
+ +S ++ SR + ++ R
Sbjct: 1901 RSRTSVTRRRSRSRASPVSRRRSR 1924
Score = 43.1 bits (100), Expect = 0.002
Identities = 80/378 (21%), Positives = 124/378 (32%), Gaps = 72/378 (19%)
Query: 1177 KSYMIPENEFHHKDPPPRNAVASVQNGPGGGPSSSSIG-----SASKSDESSTEETDKSR 1231
K Y + + P P+ + G SSS S+ K S E+ K +
Sbjct: 169 KPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRK 228
Query: 1232 ERS-------QCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEK 1284
RS + K ++ STTP S + ++++ A +D + + + K
Sbjct: 229 HRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSA-SSSDTSRSRSRSAAAKTH 287
Query: 1285 TPATTPEAR--VLGKDGKEKPKEERPNKDEKAR----ETKERTPKSDKE-KEKFKKEEKA 1337
T A + G+ G+ P R ET + P S E K+K KKE+ A
Sbjct: 288 TTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSA 347
Query: 1338 ----KDEKFKTTVPNAESKSTQERER-------------EKEPSRERDIAKEMKSKENVK 1380
+ +T P + + ER +EP A + + K
Sbjct: 348 TRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPK 407
Query: 1381 GGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYI 1440
EK P S S +S P P+P K+ H S S S
Sbjct: 408 SPEKLPQSSSSESSPPS---PQP------TKVSRHASSSPES------------------ 440
Query: 1441 NHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRR 1500
P + RE+ K+R R + K R+ S + P KR
Sbjct: 441 --PKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRS-----PATAKRG 493
Query: 1501 KEENGTMGVSKH-KSESP 1517
+ + T H +S SP
Sbjct: 494 RSRSRTPTKRGHSRSRSP 511
Score = 38.1 bits (87), Expect = 0.068
Identities = 48/233 (20%), Positives = 78/233 (33%), Gaps = 26/233 (11%)
Query: 1195 NAVASVQNGPGGGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSS 1254
+A+A++Q SSSS S+S S SS+ +SS++ G+SS
Sbjct: 2519 SALAALQPAKERRSSSSSSSSSSSSSSSSSS------------------SSSSSSSGSSS 2560
Query: 1255 NGNSGSN----SNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNK 1310
+ + GS+ A+K KE ++ + P TP R +
Sbjct: 2561 SDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSS 2620
Query: 1311 DEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIA 1370
+ + + S + K P A K ++ R R
Sbjct: 2621 SSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPG-PQALPKPASPKKPPPGERRSRSPR 2679
Query: 1371 KEMKSKENVKGGEKTPVSGSLKSPVPR---SDIPEPEREQKRRKIDTHPSPSH 1420
K + S + + +PV SP P ER +R + SPSH
Sbjct: 2680 KPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSH 2732
Score = 34.3 bits (77), Expect = 0.99
Identities = 24/91 (26%), Positives = 34/91 (37%), Gaps = 14/91 (15%)
Query: 1513 KSESPCESPYPNEKDKEKNKS--------------KSSGKEKGSDSFKSEKMDKISSGGK 1558
+ S SP P +K K+K K K S K+K S K K S
Sbjct: 175 RESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTP 234
Query: 1559 KESRHDKEKIEKKEKRDSSGGKEEKKHHKSS 1589
K R K+K K+ + + K + H +S
Sbjct: 235 KSKRKSKDKKRKRSRSTTPAPKSRRAHRSTS 265
Score = 34.3 bits (77), Expect = 0.99
Identities = 58/277 (20%), Positives = 83/277 (29%), Gaps = 48/277 (17%)
Query: 1314 ARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEM 1373
A T R P S E+ + D T P+A S+S ER PS A
Sbjct: 2378 ANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAP-- 2435
Query: 1374 KSKENVKGGEKTPVSGSLKSPV---PRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIE 1430
S SL P PRS +P +Q R I + S ++ +
Sbjct: 2436 --------------SQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVA 2481
Query: 1431 LKESSAKLY----------INHT---PPPLSKSKEREMDKKDLDKSRERSREREKKDEKD 1477
SSA + + H+ PP S ++ L ++ER R
Sbjct: 2482 TTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAKER---RSSSSSSS 2538
Query: 1478 RKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKD---------- 1527
S++ + E ++ V + SP P K+
Sbjct: 2539 SSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEP 2598
Query: 1528 ---KEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKES 1561
K K +S SS S S S SS S
Sbjct: 2599 TPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2635
Score = 34.3 bits (77), Expect = 0.99
Identities = 57/291 (19%), Positives = 95/291 (32%), Gaps = 25/291 (8%)
Query: 1196 AVASVQNGPGGGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSN 1255
AVA+ + G S+ A S E S Q A + + +SS+
Sbjct: 2479 AVATTTSSAGDHNGMLSV-PAPGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSS 2537
Query: 1256 GNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKAR 1315
+S S+S+ + + + + + PE + ++ P E R
Sbjct: 2538 SSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVAL------KRVPSPTPAPKEAVR 2591
Query: 1316 ETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKS 1375
E R P+ K K + + ++ ++ S S+ S +
Sbjct: 2592 E--GRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSP 2649
Query: 1376 KENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESS 1435
G + P S K P P E R+ ID S S ++ S +E + S
Sbjct: 2650 SPAKPGPQALPKPASPKKPPP----GERRSRSPRKPID---SLRDSRSLSYSPVERRRPS 2702
Query: 1436 AKLYINHTPPP---LSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKR 1483
+ P P S S ER + SR S +R ++ R R R
Sbjct: 2703 PQ------PSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETPSPRPMRHR 2747
>gi|156104889 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 3 [Homo sapiens]
Length = 568
Score = 77.0 bits (188), Expect = 1e-13
Identities = 80/340 (23%), Positives = 140/340 (41%), Gaps = 42/340 (12%)
Query: 1205 GGGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNK 1264
GG P+ S S+S S SS+ + S S + + +SS++ +SS+ S S +K
Sbjct: 139 GGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHK 198
Query: 1265 AVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKA------RETK 1318
+KE+ KEK + +E K + + K+ +KPKE +P K+EK +E K
Sbjct: 199 LMKEH-KEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKEPK 257
Query: 1319 --ERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIA------ 1370
+ PK D + K + + ++E S ++R++ + + +
Sbjct: 258 PMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLI 317
Query: 1371 -------KEMKSKENVKGGE---KTPVSGSLKSPVPR-SDIPEPEREQKRRKIDT----- 1414
K++K K +VK G+ ++ S KS +P DI +P I +
Sbjct: 318 LTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVDPNDSDVEENISSKSDSE 377
Query: 1415 HPSPSHSSTVKDSLIELKESSAKLYINHTPPPL-SKSKEREMDK-KDLDKSRERSREREK 1472
PSP+ SS+ S ++ + + L S E E D+ +D D E R +
Sbjct: 378 QPSPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESDEVEDNDNDSEMERPVNR 437
Query: 1473 KDEKDRKERKRDHSNND---------REVPPDLTKRRKEE 1503
+ R+ D S+++ E PP L K +
Sbjct: 438 GGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQ 477
Score = 37.4 bits (85), Expect = 0.12
Identities = 36/172 (20%), Positives = 65/172 (37%), Gaps = 4/172 (2%)
Query: 1417 SPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEK 1476
S S SS+ S KL H P S+E + K+ + +S + K K
Sbjct: 178 SSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPK 237
Query: 1477 DRKERKRDH--SNNDREVPPDLTKRRKEENGTMGVS--KHKSESPCESPYPNEKDKEKNK 1532
+ K K + + P ++K K ++ + ++ + K P + ++ K
Sbjct: 238 ENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKK 297
Query: 1533 SKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKK 1584
K S E SF S ++ K+ DK ++ + + S E+KK
Sbjct: 298 RKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKK 349
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 74.7 bits (182), Expect = 7e-13
Identities = 70/323 (21%), Positives = 140/323 (43%), Gaps = 25/323 (7%)
Query: 1291 EARVLGK-DGKEKPKEERPNKDEKARETKERTPK-SDKEKEKFKKEEKAKDEKFKTTVPN 1348
E ++L K D K K + + +KA R ++ ++E +E K +D+ K +
Sbjct: 154 EKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEV 213
Query: 1349 AESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSP-VPRSDIPEPEREQ 1407
+ + E + S K+ + KE++ + PV+ + P + + DI E E+
Sbjct: 214 LIREYSSELNAPSQESDSHPRKKKKEKKEDIF--RRFPVAPLIPYPLITKEDINAIEMEE 271
Query: 1408 KRRKIDTHPSPSHSSTVKDSLIEL-KESSAKLYINHTPPPLSKSKEREMDKKDLDKSRER 1466
+R + + T K E K+ + I + +ERE ++++ ++ RER
Sbjct: 272 DKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERERER 331
Query: 1467 SREREKKDEKDR-----------KERKRDHS-----NNDREVPPDLTKRRKEENGTMGVS 1510
REREK+ E++R KER RD + DRE D K R
Sbjct: 332 EREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDR 391
Query: 1511 KHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEK 1570
+ + E E E+++E+ + + +E+ + K +K D+ +E +++ K+E+
Sbjct: 392 EREREREREREREREREREREREREREREREREREKDKKRDREED---EEDAYERRKLER 448
Query: 1571 KEKRDSSGGKEEKKHHKSSDKHR 1593
K + + +E K+ + ++ +
Sbjct: 449 KLREKEAAYQERLKNWEIRERKK 471
Score = 74.3 bits (181), Expect = 9e-13
Identities = 75/329 (22%), Positives = 143/329 (43%), Gaps = 91/329 (27%)
Query: 1262 SNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERT 1321
S + K D K E+EK KKEK E + + K+ +E+ +E ++ + RE +ER
Sbjct: 278 SREISKFRDTHKKLEEEKGKKEK------ERQEIEKERRERERERERERERRERE-RERE 330
Query: 1322 PKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKG 1381
+ ++EKEK ++ E+ +D + T+ER+R+++ R+RD +E S N
Sbjct: 331 REREREKEKERERERERDR---------DRDRTKERDRDRDRERDRDRDRERSSDRNKD- 380
Query: 1382 GEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYIN 1441
RS E R+++R +
Sbjct: 381 ---------------RSRSREKSRDRERER------------------------------ 395
Query: 1442 HTPPPLSKSKEREMDK-KDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRR 1500
+ +ERE ++ ++ ++ RER RERE++ E++ K++KRD ++ D +RR
Sbjct: 396 ------ERERERERERERERERERERERERERERERE-KDKKRDREEDEE----DAYERR 444
Query: 1501 KEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKE 1560
K E + E+ + N + +E+ K++ KE + + +M KE
Sbjct: 445 KLER-----KLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREM-------AKE 492
Query: 1561 SRHDKEKIEKKEKRDSSGGKEEKKHHKSS 1589
++ KE +E D +++ K+++ S
Sbjct: 493 AKRLKEFLE-----DYDDDRDDPKYYRGS 516
Score = 73.9 bits (180), Expect = 1e-12
Identities = 87/388 (22%), Positives = 160/388 (41%), Gaps = 54/388 (13%)
Query: 1217 SKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKEN-DKEKGK 1275
+K D ++ E + R+ + ++K T K G + KE ++E+ +
Sbjct: 260 TKEDINAIEMEEDKRDLIS---REISKFRDTHKKLEEEKGKKEKERQEIEKERRERERER 316
Query: 1276 EKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEE 1335
E+E+E++E+ E + KEK +E +D TKER D+E+++ + E
Sbjct: 317 ERERERRERERERERER----EREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRE 372
Query: 1336 KAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPV 1395
++ D K + E +ERERE+E RER+ +E + +E + E
Sbjct: 373 RSSDRN-KDRSRSREKSRDRERERERERERERERERE-RERERERERE------------ 418
Query: 1396 PRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREM 1455
R E E+++KR + + ++ L E + + + N K++E E
Sbjct: 419 -REREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYE- 476
Query: 1456 DKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVP-----PDLTKRRKEENGTMGVS 1510
K+ ++ ER RE K+ K KE D+ ++DR+ P L KR ++ M
Sbjct: 477 --KEAEREEERRREM-AKEAKRLKEFLEDY-DDDRDDPKYYRGSALQKRLRDREKEMEAD 532
Query: 1511 KHKSESPCE-----------SPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKK 1559
+ + E +P + D E + + + + K E +
Sbjct: 533 ERDRKREKEELEEIRQRLLAEGHP-DPDAELQRMEQEAERRRQPQIKQE---------PE 582
Query: 1560 ESRHDKEKIEKKEKRDSSGGKEEKKHHK 1587
++EK EK+EKR+ +EE+ K
Sbjct: 583 SEEEEEEKQEKEEKREEPMEEEEEPEQK 610
Score = 73.9 bits (180), Expect = 1e-12
Identities = 85/391 (21%), Positives = 159/391 (40%), Gaps = 55/391 (14%)
Query: 1220 DESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEK 1279
D T+E D+ R+R + + ++S + S S + +E ++E+ +E+E+
Sbjct: 350 DRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERER 409
Query: 1280 EKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKD 1339
E++ + R E+ K+++ +++E + ER K + K +++E A
Sbjct: 410 ERERERERERERER-------EREKDKKRDREEDEEDAYERR----KLERKLREKEAAYQ 458
Query: 1340 EKFKTTVPNAESKSTQ-EREREKEPSRERDIAKEMKS----KENVKGGEKTP--VSGSLK 1392
E+ K K+ + E+E E+E R R++AKE K E+ P GS
Sbjct: 459 ERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSAL 518
Query: 1393 SPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSK- 1451
R E E +++ RK + EL+E +L P P ++ +
Sbjct: 519 QKRLRDREKEMEADERDRKREKE--------------ELEEIRQRLLAEGHPDPDAELQR 564
Query: 1452 -EREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVP---PDLTKRRKEENGTM 1507
E+E +++ + ++ E+++EK KE KR+ + E P P L + +
Sbjct: 565 MEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRPISSAP 624
Query: 1508 GVSKHK---------SESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGK 1558
VS ESPC P+E ++ + + + G S K+ +S G+
Sbjct: 625 SVSSASGNATPNTPGDESPCGIIIPHENSPDQQQPEEHRPKIG----LSLKLGASNSPGQ 680
Query: 1559 KESRHDKE-----KIEKKEKRDSSGGKEEKK 1584
S K+ K E DS ++K
Sbjct: 681 PNSVKRKKLPVDSVFNKFEDEDSDDVPRKRK 711
Score = 67.0 bits (162), Expect = 1e-10
Identities = 87/384 (22%), Positives = 154/384 (40%), Gaps = 89/384 (23%)
Query: 1215 SASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKG 1274
+ + DE + +E K R++ + A + SS N+ S +E+D
Sbjct: 187 TVTNDDEEALDEETKRRDQM------IKGAIEVLIREYSSELNAPS------QESDSHPR 234
Query: 1275 KEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKE 1334
K+K KEKKE P A ++ K +E R+ R ++ K +E
Sbjct: 235 KKK-KEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEE 293
Query: 1335 EKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSP 1394
EK K EK + + K +ERERE+E RER
Sbjct: 294 EKGKKEKERQEI----EKERRERERERERERER--------------------------- 322
Query: 1395 VPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKERE 1454
R E ERE++R K + +ERE
Sbjct: 323 --REREREREREREREK----------------------------------EKERERERE 346
Query: 1455 MDK-KDLDKSRERSREREKKDEKDRK---ERKRDHSNNDREVPPDLTKRRKEENGTMGVS 1510
D+ +D K R+R R+RE+ ++DR+ +R +D S + RE D + R+ E
Sbjct: 347 RDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRS-REKSRDRERERERERERERER 405
Query: 1511 KHKSESPCESPYPNEKDKEKNKSKSSGKEKG-SDSFKSEKMDKISSGGKKESRHDKEKIE 1569
+ + E E E+++E+ K K +E+ D+++ K+++ +KE+ + +E+++
Sbjct: 406 EREREREREREREREREREREKDKKRDREEDEEDAYERRKLER--KLREKEAAY-QERLK 462
Query: 1570 KKEKRDSSGGKEEKKHHKSSDKHR 1593
E R+ +E +K + ++ R
Sbjct: 463 NWEIRERKKTREYEKEAEREEERR 486
Score = 32.7 bits (73), Expect = 2.9
Identities = 40/174 (22%), Positives = 67/174 (38%), Gaps = 16/174 (9%)
Query: 1430 ELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNND 1489
E KE + L L +++ + K D + + KK + R +N+D
Sbjct: 133 EYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDD 192
Query: 1490 REVPPDLTKRRKEE-NGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSE 1548
E + TKRR + G + V + S +P E D K K KEK D F+
Sbjct: 193 EEALDEETKRRDQMIKGAIEVLIREYSSELNAP-SQESDSHPRKKK---KEKKEDIFRRF 248
Query: 1549 KM-----------DKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDK 1591
+ + I++ +E + D E + RD+ EE+K K ++
Sbjct: 249 PVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKER 302
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 73.2 bits (178), Expect = 2e-12
Identities = 86/387 (22%), Positives = 165/387 (42%), Gaps = 39/387 (10%)
Query: 1209 SSSSIGSASKSDESSTEETDKSRERSQCGVKAVN-KASSTTPKGNSSNGNSGSNSNKAVK 1267
+S S+ S ++++ ET + E+S+ + + + T K N + NK
Sbjct: 128 ASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENK--- 184
Query: 1268 ENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKE 1327
+ DKEK +E+E+EK ++ + V+ ++ + +EE K + PK ++E
Sbjct: 185 KEDKEK-EEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEE 243
Query: 1328 KEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPV 1387
+E+ +E + EK + E K E ER + + ER+ K + K+ E+ +
Sbjct: 244 REQ-GSDEISHHEKME-----EEDKERAEAERARLEAEERERIKAEQDKK--IADERARI 295
Query: 1388 SGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPL 1447
K+ + E E E++R + + + +K+ E ++
Sbjct: 296 EAEEKAAAQERERREAE-ERERMREEEKRAAEERQRIKEEEKRAAEERQRI--------- 345
Query: 1448 SKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTM 1507
KE E K + R+R +E EK+ ++R+ + + + K+ +E+ M
Sbjct: 346 ---KEEE---KRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAM 399
Query: 1508 GVSK---HKSESPCESPYPNEKDKEKNK-----SKSSGKEKGSD-SFKSEKMDKISSGGK 1558
+K K E E + NEK +++K K G+EKG+ K EK+ + K
Sbjct: 400 QETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFK 459
Query: 1559 KES-RHDKEKIEKKEKRDSSGGKEEKK 1584
KE + +K K +K+ K + + KK
Sbjct: 460 KEEIKDEKIKKDKEPKEEVKSFMDRKK 486
Score = 66.6 bits (161), Expect = 2e-10
Identities = 81/383 (21%), Positives = 162/383 (42%), Gaps = 42/383 (10%)
Query: 1218 KSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEK 1277
+ +ES + TD+ +Q V ++TT + + A +E ++K ++
Sbjct: 54 QEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQE 113
Query: 1278 EKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKA 1337
E++++ T +A + R D ET E+ KS+ +E+++ EE
Sbjct: 114 ALERQKEFDPTITDASL-------SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETE 166
Query: 1338 KDEK------FKTTVPNAESKSTQEREREKEPSRER--DIAKEMKSKENVKGGEKTPVSG 1389
K ++ N + +E E E++P R + E+ +E ++ V
Sbjct: 167 TVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVM 226
Query: 1390 SLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESS-AKLYINHTPPPLS 1448
SLK+ S+ P+ E E+++ + SH +++ E E+ A+L
Sbjct: 227 SLKNGQISSEEPKQEEEREQGSDEI----SHHEKMEEEDKERAEAERARL---------- 272
Query: 1449 KSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMG 1508
+++ERE K + DK R R + +EK + + +RE + KR EE
Sbjct: 273 EAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEER---- 328
Query: 1509 VSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKI 1568
+ K E E E+ + K + K + +E+ + ++ +K ++ ++ +R ++E+
Sbjct: 329 -QRIKEE---EKRAAEERQRIKEEEKRAAEERQ----RIKEEEKRAAEERQRARAEEEEK 380
Query: 1569 EKKEKRDSSGGKEEKKHHKSSDK 1591
K E++ + EEKKH K
Sbjct: 381 AKVEEQKRNKQLEEKKHAMQETK 403
Score = 61.2 bits (147), Expect = 8e-09
Identities = 75/359 (20%), Positives = 149/359 (41%), Gaps = 40/359 (11%)
Query: 1218 KSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEK 1277
+ ++ + EE + +E + + + + + + + K ++++ K+
Sbjct: 333 EEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQL 392
Query: 1278 EKEK----KEKTPATTPEARVLGKDGKEKPKEE--------RPNKDEKARETKERTPKSD 1325
E++K + K E ++ GK EK +E + +EK + + + K
Sbjct: 393 EEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQ 452
Query: 1326 KEKEKFKKEEKAKDEKFKTTV-PNAESKSTQERER---EKEPSRERDIAKEMKSKENV-- 1379
++K FKKEE KDEK K P E KS +R++ E + + ++K EN
Sbjct: 453 EDKPTFKKEE-IKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFS 511
Query: 1380 KGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLY 1439
+ G + V P+ + + E +RR+ +T ++ K+ A L
Sbjct: 512 RPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEK-------LKQKQQEAALE 564
Query: 1440 INHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKR 1499
+ K+RE +K L++ +R R++E+ D K R+E ++ + E
Sbjct: 565 LEEL------KKKREERRKVLEEEEQR-RKQEEADRKLREEEEKRRLKEEIERRRAEAAE 617
Query: 1500 RKEENGTMGVSKHKSESPCESPYPN-----EKDKEKNKS--KSSGKEKGSDSFKSEKMD 1551
++++ G+S K C +P + E+ + NKS KSSG + + K+D
Sbjct: 618 KRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKID 676
Score = 60.5 bits (145), Expect = 1e-08
Identities = 91/463 (19%), Positives = 185/463 (39%), Gaps = 46/463 (9%)
Query: 1153 QEEKEKRPDLYALAMGYSGQLKSRKSYMIPENEFHHKDPPPRNAVASVQNGPGGGPSSSS 1212
+EE+E++P ++ +++ M+ E ++ V S++NG
Sbjct: 191 EEEEEEKPKRGSIG-------ENQVEVMVEEKTTESQE---ETVVMSLKNGQISSEEPKQ 240
Query: 1213 IGSASK-SDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDK 1271
+ SDE S E + ++ + + + + + ++ ++ +K
Sbjct: 241 EEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEK 300
Query: 1272 EKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKF 1331
+E+E+ + E+ E + ++ +++ KEE E+ + KE ++ +E+++
Sbjct: 301 AAAQERERREAEERERMREEEKRAAEE-RQRIKEEEKRAAEERQRIKEEEKRAAEERQRI 359
Query: 1332 KKEEK-AKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSK-----ENVKG---G 1382
K+EEK A +E+ + E +E++R K+ ++ +E K K + ++G
Sbjct: 360 KEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVN 419
Query: 1383 EKTPVSGSLKSPVPRSDIPE--PEREQKRRKIDTHPSPSHSSTVKDSLI----ELKESSA 1436
EK L++ V + E + + KR K+ +KD I E KE
Sbjct: 420 EKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVK 479
Query: 1437 KLYINHTPPPLSKSKEREM---DKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVP 1493
KS+ E K + + R R D K+ + + + E
Sbjct: 480 SFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE-- 537
Query: 1494 PDLTKRRKE-ENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDK 1552
+L +RR E E+ K K + E+ E+ K+K + + E+ K E+ D+
Sbjct: 538 -ELRRRRGETESEEFEKLKQKQQ---EAALELEELKKKREERRKVLEEEEQRRKQEEADR 593
Query: 1553 ISSGGKKESRHDKEKI--------EKKEKRDSSGGKEEKKHHK 1587
++E R KE+I EK++K G ++KK K
Sbjct: 594 -KLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFK 635
Score = 51.6 bits (122), Expect = 6e-06
Identities = 65/348 (18%), Positives = 147/348 (42%), Gaps = 44/348 (12%)
Query: 1269 NDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKP---KEERPNKDEKARETKERTPKSD 1325
+D E+ +E ++K+E+ D E+ + R + E+ R+ +E
Sbjct: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
Query: 1326 -KEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSR--ERDIAKEMKSKENVKGG 1382
++ + + DE+ KTT N + + E + +R ER + ++ E K
Sbjct: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
Query: 1383 EKTPVSGSLKSPVPR--SDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYI 1440
+ T SL P R +D E E +K K ++ + E++E+
Sbjct: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSES----------RQERYEIEETET---- 167
Query: 1441 NHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRR 1500
++KS ++ D +D +++++ +E+E+++E+ K + + V T+ +
Sbjct: 168 ------VTKSYQKN-DWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQ 220
Query: 1501 KE------ENGTMGVSKHKSESPCESPYPN--------EKDKEKNKSKSSGKE-KGSDSF 1545
+E +NG + + K E E E+DKE+ +++ + E + +
Sbjct: 221 EETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERI 280
Query: 1546 KSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDKHR 1593
K+E+ KI+ + +K +++E+R++ + ++ K + + R
Sbjct: 281 KAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEER 328
>gi|122937227 U2-associated SR140 protein [Homo sapiens]
Length = 1029
Score = 73.2 bits (178), Expect = 2e-12
Identities = 79/337 (23%), Positives = 146/337 (43%), Gaps = 58/337 (17%)
Query: 1260 SNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKE 1319
S N+ + + K + ++ + E TT + + + +E +EE N++E++ + E
Sbjct: 747 SKKNEPIFKVAPSKWEAVDESELEAQAVTTSKWELFDQH-EESEEEENQNQEEESED--E 803
Query: 1320 RTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENV 1379
+S K +E K+E ++ SK ++ E ++ RE ++ K MK ++ +
Sbjct: 804 EDTQSSKSEEHHLYSNPIKEEMTESKF----SKYSEMSEEKRAKLREIEL-KVMKFQDEL 858
Query: 1380 KGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLY 1439
+ G++ P+ + + +++ + +D L++ +E +L
Sbjct: 859 ESGKR----------------PKKPGQSFQEQVEHY---------RDKLLQ-REKEKEL- 891
Query: 1440 INHTPPPLSKSKEREMDKKDLDKSRERSREREKKDE--KDRKERKRDHSNNDREVPPDLT 1497
+ERE DKKD +K RS+++++KDE RKERKR HS +
Sbjct: 892 ----------ERERERDKKDKEKLESRSKDKKEKDECTPTRKERKRRHSTSPSPSRSSSG 941
Query: 1498 KRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGG 1557
+R K + KSE S KE ++S+SS K+ D K K S
Sbjct: 942 RRVKSPS-------PKSE---RSERSERSHKESSRSRSSHKDSPRDVSKKAKRSPSGSRT 991
Query: 1558 KKESRHDKEKIEKKE-KRDSSGGKEEKKHHKSSDKHR 1593
K SR + + KK K+ S + + HK S K++
Sbjct: 992 PKRSRRSRSRSPKKSGKKSRSQSRSPHRSHKKSKKNK 1028
Score = 45.8 bits (107), Expect = 3e-04
Identities = 50/212 (23%), Positives = 86/212 (40%), Gaps = 17/212 (8%)
Query: 1217 SKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKE 1276
SK E S E+ K RE +K ++ S K G S + ++ ++ KE
Sbjct: 831 SKYSEMSEEKRAKLREIELKVMKFQDELESG--KRPKKPGQSFQEQVEHYRDKLLQREKE 888
Query: 1277 KEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEK 1336
KE E++ + +D K+K K E +KD+K ++ T K K +
Sbjct: 889 KELERERE------------RDKKDKEKLESRSKDKKEKDECTPTRKERKRRHSTSPSPS 936
Query: 1337 AKDEKFKTTVPNAESKSTQERER-EKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPV 1395
+ P+ +S+ ++ ER KE SR R K+ ++ K +++P
Sbjct: 937 RSSSGRRVKSPSPKSERSERSERSHKESSRSRSSHKD-SPRDVSKKAKRSPSGSRTPKRS 995
Query: 1396 PRSDIPEPERE-QKRRKIDTHPSPSHSSTVKD 1426
RS P++ +K R P SH + K+
Sbjct: 996 RRSRSRSPKKSGKKSRSQSRSPHRSHKKSKKN 1027
Score = 39.7 bits (91), Expect = 0.024
Identities = 52/227 (22%), Positives = 93/227 (40%), Gaps = 31/227 (13%)
Query: 1300 KEKPKEERPN--KDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQER 1357
+ +PK R + ++E ARE+ +P + + + + KA +T SK QE
Sbjct: 44 RTRPKSPRKHNYRNESARESLCDSPHQNLSRPLLENKLKAFSIGKMSTAKRTLSKKEQEE 103
Query: 1358 EREKEPSRER-DIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHP 1416
++KE + +I +E + +G + V ++ V + E E ++KR KI
Sbjct: 104 LKKKEDEKAAAEIYEEFLAA--FEGSDGNKVKTFVRGGVVNAAKEEHETDEKRGKIY--- 158
Query: 1417 SPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERS-----RERE 1471
SS D +SS N PP L + ++ K +K +++S +E
Sbjct: 159 --KPSSRFADQKNPPNQSS-----NERPPSLLVIETKKPPLKKGEKEKKKSNLELFKEEL 211
Query: 1472 KKDEKDRKERKRDHSNNDREVPP-----------DLTKRRKEENGTM 1507
K+ +++R ER + R PP D RR +G +
Sbjct: 212 KQIQEERDERHKTKGRLSRFEPPQSDSDGQRRSMDAPSRRNRSSGVL 258
Score = 32.0 bits (71), Expect = 4.9
Identities = 38/166 (22%), Positives = 60/166 (36%), Gaps = 27/166 (16%)
Query: 1141 GQALERRVH----KICQEEKEKRPDLYALAMGYSGQLKSRKSYMIPENEFHHKDP-PPRN 1195
GQ+ + +V K+ Q EKEK L K ++ + KD P
Sbjct: 868 GQSFQEQVEHYRDKLLQREKEKE-----LERERERDKKDKEKLESRSKDKKEKDECTPTR 922
Query: 1196 AVASVQNGPGGGPSSSSIGSASKS----------DESSTEETDKSRERSQCGVKAVNKAS 1245
++ PS SS G KS E S +E+ +SR + + V+K +
Sbjct: 923 KERKRRHSTSPSPSRSSSGRRVKSPSPKSERSERSERSHKESSRSRSSHKDSPRDVSKKA 982
Query: 1246 STTPKGN-------SSNGNSGSNSNKAVKENDKEKGKEKEKEKKEK 1284
+P G+ S S S K + + + +K KK K
Sbjct: 983 KRSPSGSRTPKRSRRSRSRSPKKSGKKSRSQSRSPHRSHKKSKKNK 1028
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 64,170,926
Number of Sequences: 37866
Number of extensions: 3208763
Number of successful extensions: 51392
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 549
Number of HSP's successfully gapped in prelim test: 1267
Number of HSP's that attempted gapping in prelim test: 16520
Number of HSP's gapped (non-prelim): 16478
length of query: 1593
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1477
effective length of database: 13,855,062
effective search space: 20463926574
effective search space used: 20463926574
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.