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Search of human proteins with 38372919
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38372919 basigin isoform 1 precursor [Homo sapiens]
(385 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38372919 basigin isoform 1 precursor [Homo sapiens] 787 0.0
gi|38372925 basigin isoform 2 precursor [Homo sapiens] 499 e-141
gi|38372923 basigin isoform 4 [Homo sapiens] 397 e-111
gi|6912646 neuroplastin isoform b precursor [Homo sapiens] 300 1e-81
gi|238624147 neuroplastin isoform c precursor [Homo sapiens] 293 1e-79
gi|9257240 neuroplastin isoform a precursor [Homo sapiens] 176 2e-44
gi|238624149 neuroplastin isoform d precursor [Homo sapiens] 170 2e-42
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 74 3e-13
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 74 3e-13
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 74 3e-13
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 73 4e-13
gi|38348215 embigin [Homo sapiens] 67 2e-11
gi|118572606 hemicentin 1 [Homo sapiens] 63 4e-10
gi|58331253 obscurin, cytoskeletal calmodulin and titin-interact... 60 3e-09
gi|148833506 obscurin, cytoskeletal calmodulin and titin-interac... 60 3e-09
gi|148886752 immunoglobulin superfamily, member 9B [Homo sapiens] 60 3e-09
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 59 6e-09
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 59 1e-08
gi|110349719 titin isoform N2-A [Homo sapiens] 58 1e-08
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 57 3e-08
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens] 57 3e-08
gi|33519481 neural cell adhesion molecule 2 precursor [Homo sapi... 56 5e-08
gi|142976733 surface glycoprotein, Ig superfamily member [Homo s... 56 6e-08
gi|239787787 kin of IRRE like 3 isoform 2 [Homo sapiens] 55 1e-07
gi|26006461 kin of IRRE like 3 isoform 1 [Homo sapiens] 55 1e-07
gi|109150416 peroxidasin [Homo sapiens] 54 2e-07
gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo ... 54 3e-07
gi|222352127 sidekick 2 [Homo sapiens] 52 9e-07
gi|4827022 contactin 2 precursor [Homo sapiens] 52 9e-07
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 51 2e-06
>gi|38372919 basigin isoform 1 precursor [Homo sapiens]
Length = 385
Score = 787 bits (2033), Expect = 0.0
Identities = 385/385 (100%), Positives = 385/385 (100%)
Query: 1 MAAALFVLLGFALLGTHGASGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEG 60
MAAALFVLLGFALLGTHGASGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEG
Sbjct: 1 MAAALFVLLGFALLGTHGASGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEG 60
Query: 61 QGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLT 120
QGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLT
Sbjct: 61 QGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLT 120
Query: 121 RAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKE 180
RAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKE
Sbjct: 121 RAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKE 180
Query: 181 DALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAML 240
DALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAML
Sbjct: 181 DALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAML 240
Query: 241 VCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYR 300
VCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYR
Sbjct: 241 VCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYR 300
Query: 301 CNGTSSKGSDQAIITLRVRSHLAALWPFLGIVAEVLVLVTIIFIYEKRRKPEDVLDDDDA 360
CNGTSSKGSDQAIITLRVRSHLAALWPFLGIVAEVLVLVTIIFIYEKRRKPEDVLDDDDA
Sbjct: 301 CNGTSSKGSDQAIITLRVRSHLAALWPFLGIVAEVLVLVTIIFIYEKRRKPEDVLDDDDA 360
Query: 361 GSAPLKSSGQHQNDKGKNVRQRNSS 385
GSAPLKSSGQHQNDKGKNVRQRNSS
Sbjct: 361 GSAPLKSSGQHQNDKGKNVRQRNSS 385
>gi|38372925 basigin isoform 2 precursor [Homo sapiens]
Length = 269
Score = 499 bits (1286), Expect = e-141
Identities = 246/246 (100%), Positives = 246/246 (100%)
Query: 140 GTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWG 199
GTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWG
Sbjct: 24 GTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWG 83
Query: 200 EYSCVFLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKIT 259
EYSCVFLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKIT
Sbjct: 84 EYSCVFLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKIT 143
Query: 260 DSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVR 319
DSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVR
Sbjct: 144 DSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVR 203
Query: 320 SHLAALWPFLGIVAEVLVLVTIIFIYEKRRKPEDVLDDDDAGSAPLKSSGQHQNDKGKNV 379
SHLAALWPFLGIVAEVLVLVTIIFIYEKRRKPEDVLDDDDAGSAPLKSSGQHQNDKGKNV
Sbjct: 204 SHLAALWPFLGIVAEVLVLVTIIFIYEKRRKPEDVLDDDDAGSAPLKSSGQHQNDKGKNV 263
Query: 380 RQRNSS 385
RQRNSS
Sbjct: 264 RQRNSS 269
Score = 52.4 bits (124), Expect = 7e-07
Identities = 42/134 (31%), Positives = 59/134 (44%), Gaps = 22/134 (16%)
Query: 1 MAAALFVLLGFALLGTHGASGAAGFV--------------------QAPLSQQRWVGGSV 40
MAAALFVLLGFALLGTHGASGAAG V ++ RW+ G V
Sbjct: 1 MAAALFVLLGFALLGTHGASGAAGTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGV 60
Query: 41 ELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLVE 100
L +A+ E + + Q +C L + + +H A S + + E
Sbjct: 61 VLKEDALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTANIQLHGPPRVKAVK--SSEHINE 118
Query: 101 EDTGTYECRASNDP 114
+T C++ + P
Sbjct: 119 GETAMLVCKSESVP 132
>gi|38372923 basigin isoform 4 [Homo sapiens]
Length = 205
Score = 397 bits (1020), Expect = e-111
Identities = 197/207 (95%), Positives = 200/207 (96%), Gaps = 4/207 (1%)
Query: 179 KEDALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTANIQLHGPPRVKAVKSSEHINEGETA 238
+ DA P ++ VDSDDQWGEYSCVFLPEPMGTANIQLHGPPRVKAVKSSEHINEGETA
Sbjct: 3 QSDASPQER----VDSDDQWGEYSCVFLPEPMGTANIQLHGPPRVKAVKSSEHINEGETA 58
Query: 239 MLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQ 298
MLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQ
Sbjct: 59 MLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQ 118
Query: 299 YRCNGTSSKGSDQAIITLRVRSHLAALWPFLGIVAEVLVLVTIIFIYEKRRKPEDVLDDD 358
YRCNGTSSKGSDQAIITLRVRSHLAALWPFLGIVAEVLVLVTIIFIYEKRRKPEDVLDDD
Sbjct: 119 YRCNGTSSKGSDQAIITLRVRSHLAALWPFLGIVAEVLVLVTIIFIYEKRRKPEDVLDDD 178
Query: 359 DAGSAPLKSSGQHQNDKGKNVRQRNSS 385
DAGSAPLKSSGQHQNDKGKNVRQRNSS
Sbjct: 179 DAGSAPLKSSGQHQNDKGKNVRQRNSS 205
>gi|6912646 neuroplastin isoform b precursor [Homo sapiens]
Length = 398
Score = 300 bits (768), Expect = 1e-81
Identities = 162/392 (41%), Positives = 237/392 (60%), Gaps = 13/392 (3%)
Query: 3 AALFVLLGFALLGTHGASGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQG 62
A +L+ +LL GA+ AGFV++P+S+ + G + EL+C+ VGSP PEIQWW+
Sbjct: 11 ALSLLLVSGSLLPGPGAAQNAGFVKSPMSETKLTGDAFELYCDVVGSPTPEIQWWYAEVN 70
Query: 63 PNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRA 122
++ QLWDGAR RV ++ Y + S + I L ED+GTYECRASNDP RN L +
Sbjct: 71 RAESFRQLWDGARKRRVTVNTAYGSNGVSVLRITRLTLEDSGTYECRASNDPKRNDLRQN 130
Query: 123 PRVKWVRAQAVVLVLEPGTVFTTVEDL--GSKIL---LTCSLNDSATEVTGHRWLKGGVV 177
P + W+RAQA + VL+ + T+ E + S +L L C+L S+ +T W K GV
Sbjct: 131 PSITWIRAQATISVLQKPRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVE 190
Query: 178 LKEDALPGQKTEFKVDSD--DQWGEYSCV--FLPEPMGTANIQLHGPPRVKAVKSSEHIN 233
L E++++ + GEY CV F+ P A I++ P + K SE+ N
Sbjct: 191 LSATRKNASNMEYRINKPRAEDSGEYHCVYHFVSAPKANATIEVKAAPDITGHKRSENKN 250
Query: 234 EGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNME 293
EG+ A + CKS P DW W K + ++N S RFF+ + + +EL+I NL +
Sbjct: 251 EGQDATMYCKSVGYPH-PDWIWRKKENGMPMDIVNTS-GRFFIINKENYTELNIVNLQIT 308
Query: 294 ADPGQYRCNGTSSKGSDQAIITLRVRSHLAALWPFLGIVAEVLVLVTIIFIYEKRRKPED 353
DPG+Y CN T++ GS + LRVRSHLA LWPFLGI+AE+++LV II +YEKR++P++
Sbjct: 309 EDPGEYECNATNAIGSASVVTVLRVRSHLAPLWPFLGILAEIIILVVIIVVYEKRKRPDE 368
Query: 354 VLDDDDAGSAPLKSSGQHQNDKGKNVRQRNSS 385
V DDD+ + P+K++ + N K KN+RQRN++
Sbjct: 369 VPDDDEP-AGPMKTNSTN-NHKDKNLRQRNTN 398
>gi|238624147 neuroplastin isoform c precursor [Homo sapiens]
Length = 394
Score = 293 bits (751), Expect = 1e-79
Identities = 160/392 (40%), Positives = 234/392 (59%), Gaps = 17/392 (4%)
Query: 3 AALFVLLGFALLGTHGASGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQG 62
A +L+ +LL GA+ AGFV++P+S+ + G + EL+C+ VGSP PEIQWW+
Sbjct: 11 ALSLLLVSGSLLPGPGAAQNAGFVKSPMSETKLTGDAFELYCDVVGSPTPEIQWWYAEVN 70
Query: 63 PNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRA 122
++ QLWDGAR RV ++ Y + S + I L ED+GTYECRASNDP RN L +
Sbjct: 71 RAESFRQLWDGARKRRVTVNTAYGSNGVSVLRITRLTLEDSGTYECRASNDPKRNDLRQN 130
Query: 123 PRVKWVRAQAVVLVLEPGTVFTTVEDL--GSKIL---LTCSLNDSATEVTGHRWLKGGVV 177
P + W+RAQA + VL+ + T+ E + S +L L C+L S+ +T W K GV
Sbjct: 131 PSITWIRAQATISVLQKPRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVE 190
Query: 178 LKEDALPGQKTEFKVDSD--DQWGEYSCV--FLPEPMGTANIQLHGPPRVKAVKSSEHIN 233
L E++++ + GEY CV F+ P A I++ P + K SE+ N
Sbjct: 191 LSATRKNASNMEYRINKPRAEDSGEYHCVYHFVSAPKANATIEVKAAPDITGHKRSENKN 250
Query: 234 EGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNME 293
EG+ A + CKS P DW W K + ++N S RFF+ + + +EL+I NL +
Sbjct: 251 EGQDATMYCKSVGYPH-PDWIWRKKENGMPMDIVNTS-GRFFIINKENYTELNIVNLQIT 308
Query: 294 ADPGQYRCNGTSSKGSDQAIITLRVRSHLAALWPFLGIVAEVLVLVTIIFIYEKRRKPED 353
DPG+Y CN T++ GS + LRVRSHLA LWPFLGI+AE+++LV II +YEKR++P++
Sbjct: 309 EDPGEYECNATNAIGSASVVTVLRVRSHLAPLWPFLGILAEIIILVVIIVVYEKRKRPDE 368
Query: 354 VLDDDDAGSAPLKSSGQHQNDKGKNVRQRNSS 385
V D + P+K++ + N K KN+RQRN++
Sbjct: 369 VPD-----AGPMKTNSTN-NHKDKNLRQRNTN 394
>gi|9257240 neuroplastin isoform a precursor [Homo sapiens]
Length = 282
Score = 176 bits (447), Expect = 2e-44
Identities = 95/237 (40%), Positives = 142/237 (59%), Gaps = 8/237 (3%)
Query: 153 ILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSD--DQWGEYSCV--FLPE 208
+ L C+L S+ +T W K GV L E++++ + GEY CV F+
Sbjct: 50 VTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYRINKPRAEDSGEYHCVYHFVSA 109
Query: 209 PMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMN 268
P A I++ P + K SE+ NEG+ A + CKS P DW W K + ++N
Sbjct: 110 PKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPH-PDWIWRKKENGMPMDIVN 168
Query: 269 GSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSHLAALWPF 328
S RFF+ + + +EL+I NL + DPG+Y CN T++ GS + LRVRSHLA LWPF
Sbjct: 169 TS-GRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAPLWPF 227
Query: 329 LGIVAEVLVLVTIIFIYEKRRKPEDVLDDDDAGSAPLKSSGQHQNDKGKNVRQRNSS 385
LGI+AE+++LV II +YEKR++P++V DDD+ + P+K++ + N K KN+RQRN++
Sbjct: 228 LGILAEIIILVVIIVVYEKRKRPDEVPDDDEP-AGPMKTNSTN-NHKDKNLRQRNTN 282
>gi|238624149 neuroplastin isoform d precursor [Homo sapiens]
Length = 278
Score = 170 bits (430), Expect = 2e-42
Identities = 93/237 (39%), Positives = 139/237 (58%), Gaps = 12/237 (5%)
Query: 153 ILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSD--DQWGEYSCV--FLPE 208
+ L C+L S+ +T W K GV L E++++ + GEY CV F+
Sbjct: 50 VTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYRINKPRAEDSGEYHCVYHFVSA 109
Query: 209 PMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMN 268
P A I++ P + K SE+ NEG+ A + CKS P DW W K + ++N
Sbjct: 110 PKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPH-PDWIWRKKENGMPMDIVN 168
Query: 269 GSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSHLAALWPF 328
S RFF+ + + +EL+I NL + DPG+Y CN T++ GS + LRVRSHLA LWPF
Sbjct: 169 TS-GRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAPLWPF 227
Query: 329 LGIVAEVLVLVTIIFIYEKRRKPEDVLDDDDAGSAPLKSSGQHQNDKGKNVRQRNSS 385
LGI+AE+++LV II +YEKR++P++V D + P+K++ + N K KN+RQRN++
Sbjct: 228 LGILAEIIILVVIIVVYEKRKRPDEVPD-----AGPMKTNSTN-NHKDKNLRQRNTN 278
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 73.6 bits (179), Expect = 3e-13
Identities = 75/298 (25%), Positives = 128/298 (42%), Gaps = 63/298 (21%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G +EL C+A G+P P I W +GQ ++L + +R RV
Sbjct: 2319 GAPMELLCDAQGTPQPNITWHKDGQ----ALTRLENNSRATRV----------------- 2357
Query: 97 TLVEEDTGTYECRASNDPD------RNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLG 150
L D G Y C A + R + P + R V+ L PG
Sbjct: 2358 -LRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPG---------- 2406
Query: 151 SKILLTCSLN-DSATEVTGHRWLKGGVVLKEDALP-----GQKTEFKVDSDDQWGEYSCV 204
+++L CS+ + A ++T HR G+VL+EDA G+ + + S G+YSC
Sbjct: 2407 -QLVLECSVEAEPAPKITWHR---DGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCT 2462
Query: 205 FLPEPMGTA---NIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVP-PVTDWAWYKITD 260
T+ +++H P +++ + +++ +TA+L C+++ VP P+ W
Sbjct: 2463 ARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSW------- 2515
Query: 261 SEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRV 318
+D+ ++ RF + L I+ + + D G Y C ++S GSD+ LRV
Sbjct: 2516 RKDRVPLDPRSPRFEILP---EGSLRIQPV-LAQDAGHYLCLASNSAGSDRQGRDLRV 2569
Score = 58.9 bits (141), Expect = 7e-09
Identities = 81/313 (25%), Positives = 108/313 (34%), Gaps = 51/313 (16%)
Query: 25 FVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHAT 84
F P + +G + L C A GSP P I W DR
Sbjct: 2940 FTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVN-----------------DRPVTEGV 2982
Query: 85 YHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFT 144
Q ST+ + ED+GTY C A N R VK +A VL G F+
Sbjct: 2983 SEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK----EAPVL---QGEAFS 3035
Query: 145 -TVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDAL-----PGQKTEFKVDSDDQW 198
VE +G I L C + V W+K G+ L+ L G T + + DD
Sbjct: 3036 YLVEPVGGSIQLDCVVR--GDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDA- 3092
Query: 199 GEYSCVFLPEPMGTAN----IQLHGPPRVKAVKSSEHINEGETAMLVCKSESVP-PVTDW 253
G Y C+ E MG A + L P + + G+ L C++ P P +W
Sbjct: 3093 GRYQCLAENE-MGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEW 3151
Query: 254 AWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAI 313
+ L R S L +EN+ D G Y C + GS A
Sbjct: 3152 L------QAGQPLRASRRLRTLPDGS-----LWLENVE-TGDAGTYDCVAHNLLGSATAR 3199
Query: 314 ITLRVRSHLAALW 326
L VR W
Sbjct: 3200 AFLVVRGEPQGSW 3212
Score = 58.5 bits (140), Expect = 1e-08
Identities = 72/301 (23%), Positives = 117/301 (38%), Gaps = 45/301 (14%)
Query: 29 PLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQH 88
P+++ SV L C A G P P++ W F+G P + W G +
Sbjct: 701 PVNKAVLENASVTLECLASGVPPPDVSW-FKGHQPVSS----WMGVTVSV---------- 745
Query: 89 AASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVED 148
+ I+ D G+Y C ASN L RV V + + PG V
Sbjct: 746 DGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVN-VPPRITLPPSLPGPVL----- 799
Query: 149 LGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQK--------TEFKVDSDDQWGE 200
+ + + LTC+ + + WLK G + PG + T + D G
Sbjct: 800 VNTPVRLTCNATGAPSPTL--MWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDS-GR 856
Query: 201 YSCVFLP---EPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYK 257
YSCV + E +Q+H PP + + + + E+ L C+S ++PP +W+K
Sbjct: 857 YSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV-LSWWK 915
Query: 258 ITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLR 317
+ + L E R V S ++ L ++ ++ D G Y C + G + L
Sbjct: 916 ----DGRPL----EPRPGVHLSADKALLQVDRADV-WDAGHYTCEALNQAGRSEKHYNLN 966
Query: 318 V 318
V
Sbjct: 967 V 967
Score = 56.6 bits (135), Expect = 4e-08
Identities = 77/309 (24%), Positives = 113/309 (36%), Gaps = 47/309 (15%)
Query: 25 FVQAPLSQQRWV----GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVH 80
F QAP Q V G L CE P P + W+ +GQ V
Sbjct: 1840 FRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQ---------------PLVL 1884
Query: 81 IHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPG 140
T + I D G Y C+ SN A R + Q P
Sbjct: 1885 AQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG-----EAVRTFTLTVQVPPTFENPK 1939
Query: 141 TVFTTVEDLGSKILLTCSLND-SATEVTGHRWLKGGVVLKEDAL-----PGQKTEFKVDS 194
T T + GS ++LTC ++ A VT WLK + ++ A+ G + +
Sbjct: 1940 TE-TVSQVAGSPLVLTCDVSGVPAPTVT---WLKDRMPVESSAVHGVVSRGGRLQLSRLQ 1995
Query: 195 DDQWGEYSCV---FLPEPMGTANIQLHGPPRVKA--VKSSEHINEGETAMLVCKSESVPP 249
Q G Y+CV E + + PR+++ V H+ EG+ L C+++ PP
Sbjct: 1996 PAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPP 2055
Query: 250 VTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGS 309
D AW K D G RF++ L ++ L +D G Y C + G
Sbjct: 2056 -PDVAWLK--DGSPLGQDMGPHLRFYLDG----GSLVLKGLR-ASDAGAYTCVAHNPAGE 2107
Query: 310 DQAIITLRV 318
D + T+ V
Sbjct: 2108 DARLHTVNV 2116
Score = 53.5 bits (127), Expect = 3e-07
Identities = 76/297 (25%), Positives = 110/297 (37%), Gaps = 55/297 (18%)
Query: 40 VELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLV 99
V L C + G P P + W G +QL GAR + Y + + I +
Sbjct: 2683 VVLTCHSTGIPAPTVSWSKAG-------AQL--GAR------GSGYRVSPSGALEIGQAL 2727
Query: 100 EEDTGTYECRASNDPDRNH----LTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILL 155
G Y C A N H LT V+A VV L P V E+ ++LL
Sbjct: 2728 PIHAGRYTCSARNSAGVAHKHVFLT-------VQASPVVKPL-PSVVRAVAEE---EVLL 2776
Query: 156 TCSLNDSATEVTGHRWLKGGV----VLKEDALPGQKTEFKVDSDDQWGEYSCV---FLPE 208
C + W K G+ + LPG + S + G Y C+
Sbjct: 2777 PCEASGIPRPTI--TWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGS 2834
Query: 209 PMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMN 268
MG + + PP ++ EG A L CK+ P IT +D ++
Sbjct: 2835 AMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEP------NITWDKDGQPVS 2888
Query: 269 GSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSHLAAL 325
G+E +F + S EL ++NL + D G Y C ++ A+ R R HL L
Sbjct: 2889 GAEGKFTIQPS---GELLVKNLEGQ-DAGTYTCT------AENAVGRARRRVHLTIL 2935
Score = 46.6 bits (109), Expect = 4e-05
Identities = 66/301 (21%), Positives = 108/301 (35%), Gaps = 69/301 (22%)
Query: 42 LHCEAVGSPVPEIQWWFEGQ--GPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLV 99
L+C+ P P++ W+ E Q D S L G + I +
Sbjct: 1579 LYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGG-----------------RVLQIPLVR 1621
Query: 100 EEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCSL 159
E+ G Y C+ASN+ + W+ + +LVL P + E+L ++ + S
Sbjct: 1622 AENAGRYSCKASNEVGED---------WLHYE--LLVLTPPVILGDTEELVEEVTVNASS 1670
Query: 160 NDS------ATEVTGHRWLKGGVVLKEDAL-----PGQKTEFKVDSDDQWGEYSCVF--- 205
S V WL+ G+ GQ + Y CV
Sbjct: 1671 TVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQ 1730
Query: 206 --LPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVP------PVTDWAWYK 257
E + T +Q+ PPR+ ++ + ++ S S+P P + WYK
Sbjct: 1731 AGSAEKLFTLRVQV--PPRIAG------LDLEQVTAILNSSVSLPCDVHAHPNPEVTWYK 1782
Query: 258 ITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLR 317
+ +AL G E V G L + + +D G Y C ++ G DQ ++ L
Sbjct: 1783 ----DSQALSLGEE----VFLLPGTHTLQLGRARL-SDSGMYTCEALNAAGRDQKLVQLS 1833
Query: 318 V 318
V
Sbjct: 1834 V 1834
Score = 45.8 bits (107), Expect = 6e-05
Identities = 75/301 (24%), Positives = 108/301 (35%), Gaps = 61/301 (20%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDR-VHIHATYHQHAASTISI 95
G V L CEA G P P++ W L DG+ L + + H ++ S + +
Sbjct: 2041 GQEVRLDCEADGQPPPDVAW-------------LKDGSPLGQDMGPHLRFYLDGGSLV-L 2086
Query: 96 DTLVEEDTGTYECRASN---DPDRNHLTRA---PRVKWVRAQAVVLVLEPGTVFTTVEDL 149
L D G Y C A N + R H P +K + LV PG + T V
Sbjct: 2087 KGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMV--- 2143
Query: 150 GSKILLTCSLNDSATEVTGHRWLKGGVVL---KEDALPGQKTEFKVDSDD--QWGEYSCV 204
C + S WLK G+ L + L G ++ G ++CV
Sbjct: 2144 -------CPVRGSPPIHVS--WLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCV 2194
Query: 205 FLPEPMGTAN----IQLHGPPRVKAVKSSEH--INEGETAMLVCKSESVP-PVTDWAWYK 257
P G A+ +Q+ PP ++ V+ + G L C++ VP P+ W
Sbjct: 2195 -AASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSW---- 2249
Query: 258 ITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLR 317
M E S QG S L +E + D G Y C S G + L
Sbjct: 2250 ---------MKDGEPLLSQSLEQGPS-LQLEAVG-AGDSGTYSCVAVSEAGEARRHFQLT 2298
Query: 318 V 318
V
Sbjct: 2299 V 2299
Score = 45.4 bits (106), Expect = 8e-05
Identities = 74/301 (24%), Positives = 114/301 (37%), Gaps = 48/301 (15%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
VG +EL C+A GSPVP IQW G+ + L V + + +T+ I
Sbjct: 512 VGQPLELPCQASGSPVPTIQWLQNGRPAEE----------LAGVQVAS-----QGTTLHI 556
Query: 96 DTLVEEDTGTYECRASNDPDRN--------HLTRAPRVKWVRAQAVVLVLEPGTVFTTVE 147
D + + +G + C+A+N+ H AP V V E + F
Sbjct: 557 DHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAAC 616
Query: 148 DLGSKILLTCSLNDSATEVTGHRWLKGGVVLKED-------ALPGQKTEFKVDSDDQWGE 200
D + + V G W G + E +LP KVD D+ G
Sbjct: 617 D--PPVHRGWGAHPKPPLVEG--WCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDE-GI 671
Query: 201 YSCV---FLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYK 257
Y+C E +++ PP ++ ++ + E + L C + VPP D +W+K
Sbjct: 672 YTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPP-PDVSWFK 730
Query: 258 ITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLR 317
S V+ S L IE + +D G YRC ++ GS + LR
Sbjct: 731 GHQP--------VSSWMGVTVSVDGRVLRIEQAQL-SDAGSYRCVASNVAGSTELRYGLR 781
Query: 318 V 318
V
Sbjct: 782 V 782
Score = 44.3 bits (103), Expect = 2e-04
Identities = 62/278 (22%), Positives = 98/278 (35%), Gaps = 45/278 (16%)
Query: 42 LHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLVEE 101
L CEA GSP P + WW +GQ +LD Y ++ + + +
Sbjct: 2592 LPCEASGSPKPLVVWWKDGQ-------------KLDFRLQQGAYRLLPSNALLLTAPGPQ 2638
Query: 102 DTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCSLND 161
D+ +EC SN+ H R+ V + + T FT + + ++LTC +
Sbjct: 2639 DSAQFECVVSNEVGEAH-----RLYQVTVHVPPTIADDQTDFTVT--MMAPVVLTC--HS 2689
Query: 162 SATEVTGHRWLKGGVVLKE-----DALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTAN-- 214
+ W K G L P E G Y+C G A+
Sbjct: 2690 TGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTC-SARNSAGVAHKH 2748
Query: 215 --IQLHGPPRVKAVKSSEHINEGETAMLVCKSESVP-PVTDWAWYKITDSEDKALMNGSE 271
+ + P VK + S E +L C++ +P P W E + G
Sbjct: 2749 VFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITW------QKEGLNVATGVS 2802
Query: 272 SRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGS 309
++ +L I + + E D G Y C +S GS
Sbjct: 2803 TQVLPG-----GQLRIAHASPE-DAGNYLCIAKNSAGS 2834
Score = 42.4 bits (98), Expect = 7e-04
Identities = 71/296 (23%), Positives = 110/296 (37%), Gaps = 51/296 (17%)
Query: 39 SVELHCEAVGSPVPEIQWWFEGQ--GPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
+V L C A+G+PVP I W G P+ L DG + +
Sbjct: 1671 TVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDG-----------------QVLQVS 1713
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLT 156
T D +Y C A N RV+ V + L LE T L S + L
Sbjct: 1714 TAEVADAASYMCVAENQAGSAEKLFTLRVQ-VPPRIAGLDLEQVTAI-----LNSSVSLP 1767
Query: 157 CSLNDSAT-EVTGHRWLKGGVVLK--EDA--LPGQKT-EFKVDSDDQWGEYSCVFL---P 207
C ++ EVT W K L E+ LPG T + G Y+C L
Sbjct: 1768 CDVHAHPNPEVT---WYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAG 1824
Query: 208 EPMGTANIQLHGPPRVKAV----KSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSED 263
+ + PP + + + + G+ A+L C+++++P T WYK D +
Sbjct: 1825 RDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPT-VTWYK--DGQP 1881
Query: 264 KALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVR 319
L ++ + +G L I+ + +D G Y C ++ G TL V+
Sbjct: 1882 LVLAQRTQ------ALRGGQRLEIQEAQV-SDKGLYSCKVSNVAGEAVRTFTLTVQ 1930
Score = 38.5 bits (88), Expect = 0.010
Identities = 67/303 (22%), Positives = 106/303 (34%), Gaps = 59/303 (19%)
Query: 40 VELHCEAVGSPVPEIQWWFEGQ-GPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTL 98
V+L CEA G P P I W+ +G P T G R + +
Sbjct: 329 VQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGR----------------QLQLGRA 372
Query: 99 VEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVV---LVLEPGTVFTTVEDLGSKILL 155
D G Y C+ASN K R V + G + G + L
Sbjct: 373 QSSDAGVYTCKASN-------AVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVAL 425
Query: 156 TCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGE-----YSCVFLPEPM 210
C + W G+ + E +T+ V + GE YSCV P
Sbjct: 426 ECVARGHPSPTLS--WHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCV-ASSPA 482
Query: 211 GTA----NIQLHGPPRVKAVKSSEHINE--GETAMLVCKSESVP-PVTDWAWYKITDSED 263
G A ++++ PP++ + + G+ L C++ P P W
Sbjct: 483 GEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQW---------- 532
Query: 264 KALMNGSESRFFVS---SSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRS 320
L NG + +SQG + LHI+++ ++ G + C T+ G+ A + + V
Sbjct: 533 --LQNGRPAEELAGVQVASQG-TTLHIDHVELD-HSGLFACQATNEAGTAGAEVEVSVHG 588
Query: 321 HLA 323
A
Sbjct: 589 EWA 591
Score = 37.7 bits (86), Expect = 0.018
Identities = 69/297 (23%), Positives = 109/297 (36%), Gaps = 54/297 (18%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G L C+A GSP P I W +GQ + + + + +
Sbjct: 2861 GSHAFLPCKARGSPEPNITWDKDGQPVSGA---------------EGKFTIQPSGELLVK 2905
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVED-----LGS 151
L +D GTY C A N + RA R R +LVL VFTT+ LG
Sbjct: 2906 NLEGQDAGTYTCTA-----ENAVGRARR----RVHLTILVL---PVFTTLPGDRSLRLGD 2953
Query: 152 KILLTCSLNDSATEVTG----HRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVF-- 205
++ L C+ S T G R + GV ++ G + S + G Y C
Sbjct: 2954 RLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDG---GSTLQRAAVSREDSGTYVCWAEN 3010
Query: 206 -LPEPMGTANIQLHGPPRVKAVKSSEHINE-GETAMLVCKSESVPPVTDWAWYKITDSED 263
+ + + + P ++ S + G + L C PV D W K D
Sbjct: 3011 RVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRG-DPVPDIHWIK-----D 3064
Query: 264 KALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRS 320
+ GS R + + G +H + D G+Y+C + G + ++ L ++S
Sbjct: 3065 GLPLRGSHLRHQLQN--GSLTIHRTERD---DAGRYQCLAENEMGVAKKVVILVLQS 3116
Score = 37.4 bits (85), Expect = 0.023
Identities = 59/255 (23%), Positives = 88/255 (34%), Gaps = 40/255 (15%)
Query: 14 LGTHGASGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDG 73
L H AG + P G L C A G P P + W +GQ G
Sbjct: 1059 LEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPV---------G 1109
Query: 74 ARLDRVHIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAV 133
A L Q+ ++ ++ TG Y C A N R R + + +
Sbjct: 1110 AEL------GLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGR--AERKFELSVLVPPEL 1161
Query: 134 VLVLEPGTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKT----- 188
+ L+P T T L S + L C RW +G +E PG+ T
Sbjct: 1162 IGDLDPLTNITAA--LHSPLTLLCEA--MGIPPPAIRWFRG----EEPVSPGEDTYLLAG 1213
Query: 189 ----EFKVDSDDQWGEYSCVF---LPEPMGTANIQLHGPPRVKAVKSSEHIN--EGETAM 239
+ + G YSC+ E ++++ PP ++ E I +G+TA
Sbjct: 1214 GWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAH 1273
Query: 240 LVCKSESVP-PVTDW 253
L+C P P W
Sbjct: 1274 LMCNVTGHPQPKLTW 1288
Score = 37.4 bits (85), Expect = 0.023
Identities = 66/300 (22%), Positives = 101/300 (33%), Gaps = 65/300 (21%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G VEL CEA G P+P + W +G+ SQ + ++ ++
Sbjct: 2230 GSLVELPCEARGVPLPLVSWMKDGE---PLLSQSLE----------------QGPSLQLE 2270
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLT 156
+ D+GTY C A ++ R + V+EP +ED G L+
Sbjct: 2271 AVGAGDSGTYSCVAVSEAGE-----------ARRHFQLTVMEP----PHIEDSGQPTELS 2315
Query: 157 CS--------LNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVFLPE 208
+ + T W K G L L +V G Y+C+
Sbjct: 2316 LTPGAPMELLCDAQGTPQPNITWHKDGQALTR--LENNSRATRVLRVRDAGLYTCL-AES 2372
Query: 209 PMGTAN----IQLHGPPRVKAVKSSEHINEGETAMLV--CKSESVP-PVTDWAWYKITDS 261
P G +++ PP + + + LV C E+ P P W I
Sbjct: 2373 PAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQ 2432
Query: 262 EDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSH 321
ED RF L ++ L+ AD G Y C ++ GS + RV H
Sbjct: 2433 EDAHTQFPERGRF----------LQLQALST-ADSGDYSCTARNAAGSTS--VAFRVEIH 2479
Score = 35.8 bits (81), Expect = 0.067
Identities = 73/310 (23%), Positives = 110/310 (35%), Gaps = 49/310 (15%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQ---GPNDTCSQLWD-------GARL--DRVHIHAT 84
G S+ L C+A G PVPEI W + Q P WD G RL + +H
Sbjct: 111 GQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFP 170
Query: 85 YHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFT 144
Q S + G+ + +A + P A VL G
Sbjct: 171 RIQPGRS----GRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQE 226
Query: 145 TVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQ------- 197
+ G+ + L C + T W K ++ LPG +V D Q
Sbjct: 227 VLGLAGADVELQCWTSGVPTPQV--EWTKD----RQPVLPG-GPHLQVQEDGQVLRITGS 279
Query: 198 ----WGEYSCV-FLPEPMGTANIQL--HGPPRVKAVKSSEH--INEGETAMLVCKSESVP 248
G Y CV F P + QL H PP + + + E L+C++ V
Sbjct: 280 HVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGV- 338
Query: 249 PVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKG 308
P + W+K D AL+ S V ++G +L + +D G Y C +++ G
Sbjct: 339 PTPNITWFK-----DGALLPTSTK---VVYTRGGRQLQLGRA-QSSDAGVYTCKASNAVG 389
Query: 309 SDQAIITLRV 318
+ + L V
Sbjct: 390 AAEKATRLDV 399
Score = 35.0 bits (79), Expect = 0.11
Identities = 60/252 (23%), Positives = 95/252 (37%), Gaps = 40/252 (15%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
+ SV L C+ P PE+ W+ + Q + + V + H T+ +
Sbjct: 1760 LNSSVSLPCDVHAHPNPEVTWYKDSQAL----------SLGEEVFLLPGTH-----TLQL 1804
Query: 96 DTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVV----LVLEPGTVFTTVEDLGS 151
D+G Y C A N R+ K V+ +V G + +G
Sbjct: 1805 GRARLSDSGMYTCEALNAAGRDQ-------KLVQLSVLVPPAFRQAPRGPQDAVLVRVGD 1857
Query: 152 KILLTCSLNDSATEVTGHRWLKGGVVL----KEDAL-PGQKTEFKVDSDDQWGEYSCV-- 204
K +L+C D+ E T W K G L + AL GQ+ E + G YSC
Sbjct: 1858 KAVLSCE-TDALPEPT-VTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVS 1915
Query: 205 -FLPEPMGTANIQLHGPPRVKAVKSSEHINE--GETAMLVCKSESVPPVTDWAWYKITDS 261
E + T + + PP + K +E +++ G +L C VP T W K
Sbjct: 1916 NVAGEAVRTFTLTVQVPPTFENPK-TETVSQVAGSPLVLTCDVSGVPAPT-VTWLKDRMP 1973
Query: 262 EDKALMNGSESR 273
+ + ++G SR
Sbjct: 1974 VESSAVHGVVSR 1985
Score = 33.9 bits (76), Expect = 0.25
Identities = 70/294 (23%), Positives = 112/294 (38%), Gaps = 54/294 (18%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G + L C G P P++ W+ +G+ AR D HI + +
Sbjct: 1269 GQTAHLMCNVTGHPQPKLTWFKDGR----------PLARGDAHHISPD-----GVLLQVL 1313
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLT 156
G Y C A+N T+ ++ + A ++ E + + I L
Sbjct: 1314 QANLSSAGHYSCIAANAVGEK--TKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLI 1371
Query: 157 C-SLNDSATEVTGHRWLKGGVVLKE----DALPG-QKTEFKVDSDDQWGEYSCVF---LP 207
C +L + +T W+K G + LPG + + G+Y+CV L
Sbjct: 1372 CEALAFPSPNIT---WMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELG 1428
Query: 208 EPMGTANIQLHGPPR-----------VKAVKSSEHINEGETAMLVCKSESVPPVTDWAWY 256
E + ++++ PP VK VK+ + T L C+S +VPP T WY
Sbjct: 1429 EAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVN----STLTLECESWAVPPPT-IRWY 1483
Query: 257 KITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSD 310
K D + SR V +GR L I+ + +D G+Y C T+ G D
Sbjct: 1484 K--DGQPVT----PSSRLQV-LGEGRL-LQIQPTQV-SDSGRYLCVATNVAGED 1528
Score = 32.7 bits (73), Expect = 0.57
Identities = 67/298 (22%), Positives = 102/298 (34%), Gaps = 56/298 (18%)
Query: 39 SVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTL 98
SV L C++ P P + WW +G+ VH+ A + + +D
Sbjct: 896 SVALECQSHAMPPPVLSWWKDGRPLEPR----------PGVHLSAD-----KALLQVDRA 940
Query: 99 VEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCS 158
D G Y C A N R+ V WV A V L T E G L+C
Sbjct: 941 DVWDAGHYTCEALNQAGRSEKHYNLNV-WV---APVFPLRESHTLTVRE--GHPTSLSCE 994
Query: 159 LNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSD------------DQWGEYSCV-- 204
W K G LPG+ + S Q G Y+C
Sbjct: 995 CR--GVPFPKISWRKDG-----QPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECS 1047
Query: 205 -FLPEPMGTANIQLHGPPRVKAVK---SSEHINEGETAMLVCKSESVPPVTDWAWYKITD 260
+ +++H PP++ + + + + A L C + PP T W + D
Sbjct: 1048 NVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPT-VTWER--D 1104
Query: 261 SEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRV 318
+ G + + +QG+S LH+E A G+Y C + G + L V
Sbjct: 1105 GQPVGAELGLQLQ-----NQGQS-LHVERA-QAAHTGRYSCVAENLAGRAERKFELSV 1155
Score = 32.3 bits (72), Expect = 0.74
Identities = 48/192 (25%), Positives = 74/192 (38%), Gaps = 32/192 (16%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G V L C A G P P + W EG L + + + S + ++
Sbjct: 420 GRPVALECVARGHPSPTLSWHHEG---------------LPVAESNESRLETDGSVLRLE 464
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLT 156
+ E +G Y C AS+ L + V+ +LV E TT+ +G + L
Sbjct: 465 SPGEASSGLYSCVASSPAGEAVLQYSVE---VQVPPQLLVAEGLGQVTTI--VGQPLELP 519
Query: 157 CSLNDSATEVTGHRWLKGGVVLKEDA---LPGQKTEFKVD--SDDQWGEYSCVFLPEPMG 211
C S + V +WL+ G +E A + Q T +D D G ++C E G
Sbjct: 520 CQA--SGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNE-AG 576
Query: 212 TA----NIQLHG 219
TA + +HG
Sbjct: 577 TAGAEVEVSVHG 588
Score = 31.2 bits (69), Expect = 1.6
Identities = 67/295 (22%), Positives = 93/295 (31%), Gaps = 59/295 (20%)
Query: 40 VELHCEAVGSPVPEIQWWFEGQG-PNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTL 98
V L CEA G P P I W EG +Q+ G +L H
Sbjct: 2774 VLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHAS---------------- 2817
Query: 99 VEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDL----GSKIL 154
ED G Y C A N + ++V P + + DL GS
Sbjct: 2818 -PEDAGNYLCIAKNSAGS-----------AMGKTRLVVQVPPVIENGLPDLSTTEGSHAF 2865
Query: 155 LTCSLNDSATEVTGHRWLKGGVVL-----KEDALPGQKTEFKVDSDDQWGEYSCVFLPEP 209
L C S W K G + K P + K G Y+C
Sbjct: 2866 LPCKARGSPE--PNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCT-AENA 2922
Query: 210 MGTANIQLHGP----PRVKAVKSSEHINEGETAMLVCKSESVP-PVTDWAWYKITDSEDK 264
+G A ++H P + + G+ L C + P P W D+
Sbjct: 2923 VGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT------VNDR 2976
Query: 265 ALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVR 319
+ G VS G S L ++ E D G Y C + G QA+ + V+
Sbjct: 2977 PVTEG------VSEQDGGSTLQRAAVSRE-DSGTYVCWAENRVGRTQAVSFVHVK 3024
Score = 30.4 bits (67), Expect = 2.8
Identities = 26/95 (27%), Positives = 37/95 (38%), Gaps = 24/95 (25%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQ--GPNDTCSQLWDGARLDRVHIHATYHQHAASTI 93
V ++ L CE+ P P I+W+ +GQ P+ L +G L
Sbjct: 1462 VNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLL----------------- 1504
Query: 94 SIDTLVEEDTGTYECRASN-----DPDRNHLTRAP 123
I D+G Y C A+N D D N L + P
Sbjct: 1505 QIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVP 1539
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 73.6 bits (179), Expect = 3e-13
Identities = 75/298 (25%), Positives = 128/298 (42%), Gaps = 63/298 (21%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G +EL C+A G+P P I W +GQ ++L + +R RV
Sbjct: 3510 GAPMELLCDAQGTPQPNITWHKDGQ----ALTRLENNSRATRV----------------- 3548
Query: 97 TLVEEDTGTYECRASNDPD------RNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLG 150
L D G Y C A + R + P + R V+ L PG
Sbjct: 3549 -LRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPG---------- 3597
Query: 151 SKILLTCSLN-DSATEVTGHRWLKGGVVLKEDALP-----GQKTEFKVDSDDQWGEYSCV 204
+++L CS+ + A ++T HR G+VL+EDA G+ + + S G+YSC
Sbjct: 3598 -QLVLECSVEAEPAPKITWHR---DGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCT 3653
Query: 205 FLPEPMGTA---NIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVP-PVTDWAWYKITD 260
T+ +++H P +++ + +++ +TA+L C+++ VP P+ W
Sbjct: 3654 ARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSW------- 3706
Query: 261 SEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRV 318
+D+ ++ RF + L I+ + + D G Y C ++S GSD+ LRV
Sbjct: 3707 RKDRVPLDPRSPRFEILP---EGSLRIQPV-LAQDAGHYLCLASNSAGSDRQGRDLRV 3760
Score = 59.3 bits (142), Expect = 6e-09
Identities = 74/305 (24%), Positives = 116/305 (38%), Gaps = 52/305 (17%)
Query: 31 SQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAA 90
SQ G V++ C A G P P I W E Q + R+H+ A
Sbjct: 616 SQHFSQGVEVKVSCSASGYPTPHISWSRESQALQED----------SRIHVDAQ------ 659
Query: 91 STISIDTLVEEDTGTYECRASNDPDRN------HLTRAPRVKWVRAQAVVLVLEPGTVFT 144
T+ I + ED G Y C+A+N+ + + T P V V A +V V
Sbjct: 660 GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAV-------- 711
Query: 145 TVEDLGSKILLTCSLNDSATEVTGHR--WLKGG--VVLKEDALPGQKTEFKVDSDDQWGE 200
G + +L C A+ V R W +GG ++L + K + G
Sbjct: 712 -----GEEAVLVC----EASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGT 762
Query: 201 YSCVFLPEPMGTANIQLH----GPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWY 256
Y+C + E +G A+ ++ P++ + + G +A+L C++ PP T +
Sbjct: 763 YTCRAVNE-LGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPT--VTW 819
Query: 257 KITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITL 316
+ D + L G+ R S L E++ E D Y C + G QA L
Sbjct: 820 RRGDGQPLGLRLGA-GRGSRSRQPDSGVLFFESVAPE-DQAPYVCEARNVFGKVQAEARL 877
Query: 317 RVRSH 321
V H
Sbjct: 878 IVTGH 882
Score = 58.9 bits (141), Expect = 7e-09
Identities = 81/313 (25%), Positives = 108/313 (34%), Gaps = 51/313 (16%)
Query: 25 FVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHAT 84
F P + +G + L C A GSP P I W DR
Sbjct: 4131 FTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVN-----------------DRPVTEGV 4173
Query: 85 YHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFT 144
Q ST+ + ED+GTY C A N R VK +A VL G F+
Sbjct: 4174 SEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK----EAPVL---QGEAFS 4226
Query: 145 -TVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDAL-----PGQKTEFKVDSDDQW 198
VE +G I L C + V W+K G+ L+ L G T + + DD
Sbjct: 4227 YLVEPVGGSIQLDCVVR--GDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDA- 4283
Query: 199 GEYSCVFLPEPMGTAN----IQLHGPPRVKAVKSSEHINEGETAMLVCKSESVP-PVTDW 253
G Y C+ E MG A + L P + + G+ L C++ P P +W
Sbjct: 4284 GRYQCLAENE-MGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEW 4342
Query: 254 AWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAI 313
+ L R S L +EN+ D G Y C + GS A
Sbjct: 4343 L------QAGQPLRASRRLRTLPDGS-----LWLENVE-TGDAGTYDCVAHNLLGSATAR 4390
Query: 314 ITLRVRSHLAALW 326
L VR W
Sbjct: 4391 AFLVVRGEPQGSW 4403
Score = 58.5 bits (140), Expect = 1e-08
Identities = 72/301 (23%), Positives = 117/301 (38%), Gaps = 45/301 (14%)
Query: 29 PLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQH 88
P+++ SV L C A G P P++ W F+G P + W G +
Sbjct: 1892 PVNKAVLENASVTLECLASGVPPPDVSW-FKGHQPVSS----WMGVTVSV---------- 1936
Query: 89 AASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVED 148
+ I+ D G+Y C ASN L RV V + + PG V
Sbjct: 1937 DGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVN-VPPRITLPPSLPGPVL----- 1990
Query: 149 LGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQK--------TEFKVDSDDQWGE 200
+ + + LTC+ + + WLK G + PG + T + D G
Sbjct: 1991 VNTPVRLTCNATGAPSPTL--MWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDS-GR 2047
Query: 201 YSCVFLP---EPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYK 257
YSCV + E +Q+H PP + + + + E+ L C+S ++PP +W+K
Sbjct: 2048 YSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV-LSWWK 2106
Query: 258 ITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLR 317
+ + L E R V S ++ L ++ ++ D G Y C + G + L
Sbjct: 2107 ----DGRPL----EPRPGVHLSADKALLQVDRADV-WDAGHYTCEALNQAGHSEKHYNLN 2157
Query: 318 V 318
V
Sbjct: 2158 V 2158
Score = 56.6 bits (135), Expect = 4e-08
Identities = 77/309 (24%), Positives = 113/309 (36%), Gaps = 47/309 (15%)
Query: 25 FVQAPLSQQRWV----GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVH 80
F QAP Q V G L CE P P + W+ +GQ V
Sbjct: 3031 FRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQ---------------PLVL 3075
Query: 81 IHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPG 140
T + I D G Y C+ SN A R + Q P
Sbjct: 3076 AQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG-----EAVRTFTLTVQVPPTFENPK 3130
Query: 141 TVFTTVEDLGSKILLTCSLND-SATEVTGHRWLKGGVVLKEDAL-----PGQKTEFKVDS 194
T T + GS ++LTC ++ A VT WLK + ++ A+ G + +
Sbjct: 3131 TE-TVSQVAGSPLVLTCDVSGVPAPTVT---WLKDRMPVESSAVHGVVSRGGRLQLSRLQ 3186
Query: 195 DDQWGEYSCV---FLPEPMGTANIQLHGPPRVKA--VKSSEHINEGETAMLVCKSESVPP 249
Q G Y+CV E + + PR+++ V H+ EG+ L C+++ PP
Sbjct: 3187 PAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPP 3246
Query: 250 VTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGS 309
D AW K D G RF++ L ++ L +D G Y C + G
Sbjct: 3247 -PDVAWLK--DGSPLGQDMGPHLRFYLDG----GSLVLKGLR-ASDAGAYTCVAHNPAGE 3298
Query: 310 DQAIITLRV 318
D + T+ V
Sbjct: 3299 DARLHTVNV 3307
Score = 53.5 bits (127), Expect = 3e-07
Identities = 63/239 (26%), Positives = 92/239 (38%), Gaps = 29/239 (12%)
Query: 87 QHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTV 146
Q A ++ I ++ D G Y+C ASN N +TRA VR V + F+
Sbjct: 566 QLADLSLEISGIIPTDGGRYQCVASN---ANGVTRASVWLLVREAPQVSIHTSSQHFSQ- 621
Query: 147 EDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDA---LPGQKTEF-KVDSDDQWGEYS 202
G ++ ++CS + T W + L+ED+ + Q T + + + G YS
Sbjct: 622 ---GVEVKVSCSASGYPTPHIS--WSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYS 676
Query: 203 CVFLPE---PMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKIT 259
C E T + PP V AV + + GE A+LVC++ VPP WY+
Sbjct: 677 CQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPP-PRVIWYR-- 733
Query: 260 DSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRV 318
G +L I E D G Y C + G A I L V
Sbjct: 734 ---------GGLEMILAPEGSSSGKLRIP-AAQERDAGTYTCRAVNELGDASAEIQLAV 782
Score = 53.5 bits (127), Expect = 3e-07
Identities = 76/297 (25%), Positives = 110/297 (37%), Gaps = 55/297 (18%)
Query: 40 VELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLV 99
V L C + G P P + W G +QL GAR + Y + + I +
Sbjct: 3874 VVLTCHSTGIPAPTVSWSKAG-------AQL--GAR------GSGYRVSPSGALEIGQAL 3918
Query: 100 EEDTGTYECRASNDPDRNH----LTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILL 155
G Y C A N H LT V+A VV L P V E+ ++LL
Sbjct: 3919 PIHAGRYTCSARNSAGVAHKHVFLT-------VQASPVVKPL-PSVVRAVAEE---EVLL 3967
Query: 156 TCSLNDSATEVTGHRWLKGGV----VLKEDALPGQKTEFKVDSDDQWGEYSCV---FLPE 208
C + W K G+ + LPG + S + G Y C+
Sbjct: 3968 PCEASGIPRPTI--TWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGS 4025
Query: 209 PMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMN 268
MG + + PP ++ EG A L CK+ P IT +D ++
Sbjct: 4026 AMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEP------NITWDKDGQPVS 4079
Query: 269 GSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSHLAAL 325
G+E +F + S EL ++NL + D G Y C ++ A+ R R HL L
Sbjct: 4080 GAEGKFTIQPS---GELLVKNLEGQ-DAGTYTCT------AENAVGRARRRVHLTIL 4126
Score = 51.2 bits (121), Expect = 2e-06
Identities = 75/301 (24%), Positives = 112/301 (37%), Gaps = 44/301 (14%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQ---GPNDTCSQLWDGARLDRVHIHATYHQHAASTI 93
G S+ L C+A G PVPEI W + Q P WD +V H + ++
Sbjct: 1315 GQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWD-LGWGQVGGHRLLDE--GQSL 1371
Query: 94 SIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKI 153
+ E D+G Y CRA N A R + VL G + G+ +
Sbjct: 1372 HFPRIQEGDSGLYSCRAENQAG-----TAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADV 1426
Query: 154 LLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQ-----------WGEYS 202
L C + T W K ++ LPG +V D Q G Y
Sbjct: 1427 ELQCWTSGVPTPQV--EWTKD----RQPVLPG-GPHLQVQEDGQVLRITGSHVGDEGRYQ 1479
Query: 203 CV-FLPEPMGTANIQL--HGPPRVKAVKSSEH--INEGETAMLVCKSESVPPVTDWAWYK 257
CV F P + QL H PP + + + E L+C++ V P + W+K
Sbjct: 1480 CVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGV-PTPNITWFK 1538
Query: 258 ITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLR 317
D AL+ S V ++G +L + +D G Y C +++ G+ + L
Sbjct: 1539 -----DGALLPTSTK---VVYTRGGRQLQLGRA-QSSDAGVYTCKASNAVGAAEKATRLD 1589
Query: 318 V 318
V
Sbjct: 1590 V 1590
Score = 46.6 bits (109), Expect = 4e-05
Identities = 66/301 (21%), Positives = 108/301 (35%), Gaps = 69/301 (22%)
Query: 42 LHCEAVGSPVPEIQWWFEGQ--GPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLV 99
L+C+ P P++ W+ E Q D S L G + I +
Sbjct: 2770 LYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGG-----------------RVLQIPLVR 2812
Query: 100 EEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCSL 159
E+ G Y C+ASN+ + W+ + +LVL P + E+L ++ + S
Sbjct: 2813 AENAGRYSCKASNEVGED---------WLHYE--LLVLTPPVILGDTEELVEEVTVNASS 2861
Query: 160 NDS------ATEVTGHRWLKGGVVLKEDAL-----PGQKTEFKVDSDDQWGEYSCVF--- 205
S V WL+ G+ GQ + Y CV
Sbjct: 2862 TVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQ 2921
Query: 206 --LPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVP------PVTDWAWYK 257
E + T +Q+ PPR+ ++ + ++ S S+P P + WYK
Sbjct: 2922 AGSAEKLFTLRVQV--PPRIAG------LDLEQVTAILNSSVSLPCDVHAHPNPEVTWYK 2973
Query: 258 ITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLR 317
+ +AL G E V G L + + +D G Y C ++ G DQ ++ L
Sbjct: 2974 ----DSQALSLGEE----VFLLPGTHTLQLGRARL-SDSGMYTCEALNAAGRDQKLVQLS 3024
Query: 318 V 318
V
Sbjct: 3025 V 3025
Score = 45.8 bits (107), Expect = 6e-05
Identities = 75/301 (24%), Positives = 108/301 (35%), Gaps = 61/301 (20%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDR-VHIHATYHQHAASTISI 95
G V L CEA G P P++ W L DG+ L + + H ++ S + +
Sbjct: 3232 GQEVRLDCEADGQPPPDVAW-------------LKDGSPLGQDMGPHLRFYLDGGSLV-L 3277
Query: 96 DTLVEEDTGTYECRASN---DPDRNHLTRA---PRVKWVRAQAVVLVLEPGTVFTTVEDL 149
L D G Y C A N + R H P +K + LV PG + T V
Sbjct: 3278 KGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMV--- 3334
Query: 150 GSKILLTCSLNDSATEVTGHRWLKGGVVL---KEDALPGQKTEFKVDSDD--QWGEYSCV 204
C + S WLK G+ L + L G ++ G ++CV
Sbjct: 3335 -------CPVRGSPPIHVS--WLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCV 3385
Query: 205 FLPEPMGTAN----IQLHGPPRVKAVKSSEH--INEGETAMLVCKSESVP-PVTDWAWYK 257
P G A+ +Q+ PP ++ V+ + G L C++ VP P+ W
Sbjct: 3386 -AASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSW---- 3440
Query: 258 ITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLR 317
M E S QG S L +E + D G Y C S G + L
Sbjct: 3441 ---------MKDGEPLLSQSLEQGPS-LQLEAVG-AGDSGTYSCVAVSEAGEARRHFQLT 3489
Query: 318 V 318
V
Sbjct: 3490 V 3490
Score = 45.4 bits (106), Expect = 8e-05
Identities = 74/301 (24%), Positives = 114/301 (37%), Gaps = 48/301 (15%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
VG +EL C+A GSPVP IQW G+ + L V + + +T+ I
Sbjct: 1703 VGQPLELPCQASGSPVPTIQWLQNGRPAEE----------LAGVQVAS-----QGTTLHI 1747
Query: 96 DTLVEEDTGTYECRASNDPDRN--------HLTRAPRVKWVRAQAVVLVLEPGTVFTTVE 147
D + + +G + C+A+N+ H AP V V E + F
Sbjct: 1748 DHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAAC 1807
Query: 148 DLGSKILLTCSLNDSATEVTGHRWLKGGVVLKED-------ALPGQKTEFKVDSDDQWGE 200
D + + V G W G + E +LP KVD D+ G
Sbjct: 1808 D--PPVHRGWGAHPKPPLVEG--WCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDE-GI 1862
Query: 201 YSCV---FLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYK 257
Y+C E +++ PP ++ ++ + E + L C + VPP D +W+K
Sbjct: 1863 YTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPP-PDVSWFK 1921
Query: 258 ITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLR 317
S V+ S L IE + +D G YRC ++ GS + LR
Sbjct: 1922 GHQP--------VSSWMGVTVSVDGRVLRIEQAQL-SDAGSYRCVASNVAGSTELRYGLR 1972
Query: 318 V 318
V
Sbjct: 1973 V 1973
Score = 44.3 bits (103), Expect = 2e-04
Identities = 62/278 (22%), Positives = 98/278 (35%), Gaps = 45/278 (16%)
Query: 42 LHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLVEE 101
L CEA GSP P + WW +GQ +LD Y ++ + + +
Sbjct: 3783 LPCEASGSPKPLVVWWKDGQ-------------KLDFRLQQGAYRLLPSNALLLTAPGPQ 3829
Query: 102 DTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCSLND 161
D+ +EC SN+ H R+ V + + T FT + + ++LTC +
Sbjct: 3830 DSAQFECVVSNEVGEAH-----RLYQVTVHVPPTIADDQTDFTVT--MMAPVVLTC--HS 3880
Query: 162 SATEVTGHRWLKGGVVLKE-----DALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTAN-- 214
+ W K G L P E G Y+C G A+
Sbjct: 3881 TGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTC-SARNSAGVAHKH 3939
Query: 215 --IQLHGPPRVKAVKSSEHINEGETAMLVCKSESVP-PVTDWAWYKITDSEDKALMNGSE 271
+ + P VK + S E +L C++ +P P W E + G
Sbjct: 3940 VFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITW------QKEGLNVATGVS 3993
Query: 272 SRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGS 309
++ +L I + + E D G Y C +S GS
Sbjct: 3994 TQVLPG-----GQLRIAHASPE-DAGNYLCIAKNSAGS 4025
Score = 42.4 bits (98), Expect = 7e-04
Identities = 71/296 (23%), Positives = 110/296 (37%), Gaps = 51/296 (17%)
Query: 39 SVELHCEAVGSPVPEIQWWFEGQ--GPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
+V L C A+G+PVP I W G P+ L DG + +
Sbjct: 2862 TVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDG-----------------QVLQVS 2904
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLT 156
T D +Y C A N RV+ V + L LE T L S + L
Sbjct: 2905 TAEVADAASYMCVAENQAGSAEKLFTLRVQ-VPPRIAGLDLEQVTAI-----LNSSVSLP 2958
Query: 157 CSLNDSAT-EVTGHRWLKGGVVLK--EDA--LPGQKT-EFKVDSDDQWGEYSCVFL---P 207
C ++ EVT W K L E+ LPG T + G Y+C L
Sbjct: 2959 CDVHAHPNPEVT---WYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAG 3015
Query: 208 EPMGTANIQLHGPPRVKAV----KSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSED 263
+ + PP + + + + G+ A+L C+++++P T WYK D +
Sbjct: 3016 RDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPT-VTWYK--DGQP 3072
Query: 264 KALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVR 319
L ++ + +G L I+ + +D G Y C ++ G TL V+
Sbjct: 3073 LVLAQRTQ------ALRGGQRLEIQEAQV-SDKGLYSCKVSNVAGEAVRTFTLTVQ 3121
Score = 41.6 bits (96), Expect = 0.001
Identities = 74/305 (24%), Positives = 107/305 (35%), Gaps = 62/305 (20%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
+G S L C A G P P + W +G R R Q + +
Sbjct: 799 LGRSALLACRATGRPPPTVTW---RRGDGQPLGLRLGAGRGSRSR------QPDSGVLFF 849
Query: 96 DTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVL-----EPGTVFTTVEDL- 149
+++ ED Y C A N + V+A+A ++V + + TV L
Sbjct: 850 ESVAPEDQAPYVCEARNVFGK-----------VQAEARLIVTGHAPPQIASSAPTVRVLE 898
Query: 150 GSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSD--------DQWGEY 201
G + L C + + + WLK G L PG + + D + G Y
Sbjct: 899 GQPVSLPCIVL-AGRPLPERHWLKDGRPLP----PGSRHSIRADGSLHLDRALQEHAGRY 953
Query: 202 SCVFLPEPMGTANIQ-------LHGPPRVKAVKSSEHINEGETAMLVCKSESVP-PVTDW 253
SCV TA Q + PPR+ + NEG A L C + VP P W
Sbjct: 954 SCV----ATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITW 1009
Query: 254 AWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAI 313
E AL S + S +G L I + + D G Y C T++ G
Sbjct: 1010 T------KETNALT--SRGPHYNVSKEG--TLLIAQPSAQ-DAGAYVCTATNTVGFSSQE 1058
Query: 314 ITLRV 318
+ L V
Sbjct: 1059 MRLSV 1063
Score = 38.1 bits (87), Expect = 0.013
Identities = 71/318 (22%), Positives = 108/318 (33%), Gaps = 65/318 (20%)
Query: 33 QRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAAST 92
+R G + L C A G+P P++ W +GP+ + +H +
Sbjct: 1217 ERVAGENASLPCPARGTPKPQVTW---RKGPSS-----------EPLHGQPGVAVLEEGS 1262
Query: 93 ISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSK 152
+ + ++ D+G YEC+A+N+ RA V +V + E G G
Sbjct: 1263 LFLASVSPADSGDYECQATNEVGSTS-RRAKLVVYVPPS----IREDGRKANVSGMAGQS 1317
Query: 153 ILLTCSLNDSATEVTGHRWLK-----------------------GGVVLKEDALPGQKTE 189
+ L C N V WLK GG L ++ GQ
Sbjct: 1318 LTLECDAN--GFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDE---GQSLH 1372
Query: 190 FKVDSDDQWGEYSCVFLPEPMGTANIQLH----GPPRVKAVKSSEHI--NEGETAMLVCK 243
F + G YSC GTA H PP V +++ + G L C
Sbjct: 1373 FPRIQEGDSGLYSC-RAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCW 1431
Query: 244 SESVP-PVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCN 302
+ VP P +W T L G + + L I ++ D G+Y+C
Sbjct: 1432 TSGVPTPQVEW-----TKDRQPVLPGGPH----LQVQEDGQVLRITGSHV-GDEGRYQCV 1481
Query: 303 GTSSKGSDQAIITLRVRS 320
S G LRV +
Sbjct: 1482 AFSPAGQQARDFQLRVHA 1499
Score = 37.7 bits (86), Expect = 0.018
Identities = 69/297 (23%), Positives = 109/297 (36%), Gaps = 54/297 (18%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G L C+A GSP P I W +GQ + + + + +
Sbjct: 4052 GSHAFLPCKARGSPEPNITWDKDGQPVSGA---------------EGKFTIQPSGELLVK 4096
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVED-----LGS 151
L +D GTY C A N + RA R R +LVL VFTT+ LG
Sbjct: 4097 NLEGQDAGTYTCTA-----ENAVGRARR----RVHLTILVL---PVFTTLPGDRSLRLGD 4144
Query: 152 KILLTCSLNDSATEVTG----HRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVF-- 205
++ L C+ S T G R + GV ++ G + S + G Y C
Sbjct: 4145 RLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDG---GSTLQRAAVSREDSGTYVCWAEN 4201
Query: 206 -LPEPMGTANIQLHGPPRVKAVKSSEHINE-GETAMLVCKSESVPPVTDWAWYKITDSED 263
+ + + + P ++ S + G + L C PV D W K D
Sbjct: 4202 RVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRG-DPVPDIHWIK-----D 4255
Query: 264 KALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRS 320
+ GS R + + G +H + D G+Y+C + G + ++ L ++S
Sbjct: 4256 GLPLRGSHLRHQLQN--GSLTIHRTERD---DAGRYQCLAENEMGVAKKVVILVLQS 4307
Score = 37.4 bits (85), Expect = 0.023
Identities = 59/255 (23%), Positives = 88/255 (34%), Gaps = 40/255 (15%)
Query: 14 LGTHGASGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDG 73
L H AG + P G L C A G P P + W +GQ G
Sbjct: 2250 LEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPV---------G 2300
Query: 74 ARLDRVHIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAV 133
A L Q+ ++ ++ TG Y C A N R R + + +
Sbjct: 2301 AEL------GLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGR--AERKFELSVLVPPEL 2352
Query: 134 VLVLEPGTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKT----- 188
+ L+P T T L S + L C RW +G +E PG+ T
Sbjct: 2353 IGDLDPLTNITAA--LHSPLTLLCEA--MGIPPPAIRWFRG----EEPVSPGEDTYLLAG 2404
Query: 189 ----EFKVDSDDQWGEYSCVF---LPEPMGTANIQLHGPPRVKAVKSSEHIN--EGETAM 239
+ + G YSC+ E ++++ PP ++ E I +G+TA
Sbjct: 2405 GWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAH 2464
Query: 240 LVCKSESVP-PVTDW 253
L+C P P W
Sbjct: 2465 LMCNVTGHPQPKLTW 2479
Score = 37.4 bits (85), Expect = 0.023
Identities = 66/300 (22%), Positives = 101/300 (33%), Gaps = 65/300 (21%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G VEL CEA G P+P + W +G+ SQ + ++ ++
Sbjct: 3421 GSLVELPCEARGVPLPLVSWMKDGE---PLLSQSLE----------------QGPSLQLE 3461
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLT 156
+ D+GTY C A ++ R + V+EP +ED G L+
Sbjct: 3462 AVGAGDSGTYSCVAVSEAGE-----------ARRHFQLTVMEP----PHIEDSGQPTELS 3506
Query: 157 CS--------LNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVFLPE 208
+ + T W K G L L +V G Y+C+
Sbjct: 3507 LTPGAPMELLCDAQGTPQPNITWHKDGQALTR--LENNSRATRVLRVRDAGLYTCL-AES 3563
Query: 209 PMGTAN----IQLHGPPRVKAVKSSEHINEGETAMLV--CKSESVP-PVTDWAWYKITDS 261
P G +++ PP + + + LV C E+ P P W I
Sbjct: 3564 PAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQ 3623
Query: 262 EDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSH 321
ED RF L ++ L+ AD G Y C ++ GS + RV H
Sbjct: 3624 EDAHTQFPERGRF----------LQLQALST-ADSGDYSCTARNAAGSTS--VAFRVEIH 3670
Score = 35.8 bits (81), Expect = 0.067
Identities = 74/338 (21%), Positives = 120/338 (35%), Gaps = 91/338 (26%)
Query: 37 GGSVELHCEAV-GSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
G V L C + G P+PE W +G+ L G+R + A ++ +
Sbjct: 899 GQPVSLPCIVLAGRPLPERHWLKDGR-------PLPPGSR---------HSIRADGSLHL 942
Query: 96 DTLVEEDTGTYECRASND--------------PDRNHLTR-------------------- 121
D ++E G Y C A+N P R H T
Sbjct: 943 DRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGV 1002
Query: 122 -APRVKWVRAQAVVL-------VLEPGTVFT---TVEDLGSKILL---TCSLNDSATEVT 167
AP + W + + V + GT+ + +D G+ + T + ++
Sbjct: 1003 PAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLS 1062
Query: 168 GHRWLKGGVVLKEDAL--PGQKTEFKVDSDDQWGEYSCVFLPEPMGTAN----IQLHGPP 221
+R V +E L G +V D G Y C P G+A+ + + PP
Sbjct: 1063 VNRLALSKYVWEEYGLLPSGSLRLAQVQVGDS-GHYECT-ASNPAGSASHRYVLGVQVPP 1120
Query: 222 RVKAVKSSEHINEGETAMLVCKSESVP-PVTDWAWYKITDSEDKALMNGSESRFFVSSSQ 280
+V+ + GE L C +E P P W S+D ++ G + V +
Sbjct: 1121 QVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSW-------SKDGVVLQGRGPQGSVHFAA 1173
Query: 281 GRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRV 318
R+ +D G+YRC ++S G D + LRV
Sbjct: 1174 IRT----------SDAGRYRCEASNSAGVDAWEVELRV 1201
Score = 35.0 bits (79), Expect = 0.11
Identities = 60/252 (23%), Positives = 95/252 (37%), Gaps = 40/252 (15%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
+ SV L C+ P PE+ W+ + Q + + V + H T+ +
Sbjct: 2951 LNSSVSLPCDVHAHPNPEVTWYKDSQAL----------SLGEEVFLLPGTH-----TLQL 2995
Query: 96 DTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVV----LVLEPGTVFTTVEDLGS 151
D+G Y C A N R+ K V+ +V G + +G
Sbjct: 2996 GRARLSDSGMYTCEALNAAGRDQ-------KLVQLSVLVPPAFRQAPRGPQDAVLVRVGD 3048
Query: 152 KILLTCSLNDSATEVTGHRWLKGGVVL----KEDAL-PGQKTEFKVDSDDQWGEYSCV-- 204
K +L+C D+ E T W K G L + AL GQ+ E + G YSC
Sbjct: 3049 KAVLSCE-TDALPEPT-VTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVS 3106
Query: 205 -FLPEPMGTANIQLHGPPRVKAVKSSEHINE--GETAMLVCKSESVPPVTDWAWYKITDS 261
E + T + + PP + K +E +++ G +L C VP T W K
Sbjct: 3107 NVAGEAVRTFTLTVQVPPTFENPK-TETVSQVAGSPLVLTCDVSGVPAPT-VTWLKDRMP 3164
Query: 262 EDKALMNGSESR 273
+ + ++G SR
Sbjct: 3165 VESSAVHGVVSR 3176
Score = 33.9 bits (76), Expect = 0.25
Identities = 70/294 (23%), Positives = 112/294 (38%), Gaps = 54/294 (18%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G + L C G P P++ W+ +G+ AR D HI + +
Sbjct: 2460 GQTAHLMCNVTGHPQPKLTWFKDGR----------PLARGDAHHISPD-----GVLLQVL 2504
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLT 156
G Y C A+N T+ ++ + A ++ E + + I L
Sbjct: 2505 QANLSSAGHYSCIAANAVGEK--TKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLI 2562
Query: 157 C-SLNDSATEVTGHRWLKGGVVLKE----DALPG-QKTEFKVDSDDQWGEYSCVF---LP 207
C +L + +T W+K G + LPG + + G+Y+CV L
Sbjct: 2563 CEALAFPSPNIT---WMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELG 2619
Query: 208 EPMGTANIQLHGPPR-----------VKAVKSSEHINEGETAMLVCKSESVPPVTDWAWY 256
E + ++++ PP VK VK+ + T L C+S +VPP T WY
Sbjct: 2620 EAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVN----STLTLECESWAVPPPT-IRWY 2674
Query: 257 KITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSD 310
K D + SR V +GR L I+ + +D G+Y C T+ G D
Sbjct: 2675 K--DGQPVT----PSSRLQV-LGEGRL-LQIQPTQV-SDSGRYLCVATNVAGED 2719
Score = 33.1 bits (74), Expect = 0.43
Identities = 37/153 (24%), Positives = 62/153 (40%), Gaps = 25/153 (16%)
Query: 181 DALPGQKTEFKVDSDDQW----------GEYSCVFLPEPMGT----ANIQLHGPPRVKAV 226
+A G++ F+ + W G Y C + GT A I + PP
Sbjct: 464 EARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRA-GTGRAKAQIVVTDPPPQLVP 522
Query: 227 KSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELH 286
+ ++ GETA+L C+ V A Y +T D ++ S R + L
Sbjct: 523 APNVTVSPGETAVLSCR------VLGEAPYNLTWVRDWRVLPASTGRV---AQLADLSLE 573
Query: 287 IENLNMEADPGQYRCNGTSSKGSDQAIITLRVR 319
I + + D G+Y+C +++ G +A + L VR
Sbjct: 574 ISGI-IPTDGGRYQCVASNANGVTRASVWLLVR 605
Score = 33.1 bits (74), Expect = 0.43
Identities = 55/221 (24%), Positives = 76/221 (34%), Gaps = 40/221 (18%)
Query: 102 DTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCSLND 161
D+G YEC ASN + ++V V ++PG V +G + L C
Sbjct: 1093 DSGHYECTASNP------AGSASHRYVLGVQVPPQVQPGPRVLKVL-VGEALDLNCVAEG 1145
Query: 162 SATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTANI------ 215
+ W K GVVL+ P F G Y C E +A +
Sbjct: 1146 NPEPQLS--WSKDGVVLQGRG-PQGSVHFAAIRTSDAGRYRC----EASNSAGVDAWEVE 1198
Query: 216 -QLHGPPRVKAVKSSEHINE--GETAMLVCKSESVPPVTDWAWYKITDSEDKALMNG--- 269
++ PP A ++S + GE A L C + P W K SE G
Sbjct: 1199 LRVLEPPHWGADETSGLLERVAGENASLPCPARGTPK-PQVTWRKGPSSEPLHGQPGVAV 1257
Query: 270 -SESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGS 309
E F++S AD G Y C T+ GS
Sbjct: 1258 LEEGSLFLASVS------------PADSGDYECQATNEVGS 1286
Score = 32.3 bits (72), Expect = 0.74
Identities = 48/192 (25%), Positives = 74/192 (38%), Gaps = 32/192 (16%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G V L C A G P P + W EG L + + + S + ++
Sbjct: 1611 GRPVALECVARGHPSPTLSWHHEG---------------LPVAESNESRLETDGSVLRLE 1655
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLT 156
+ E +G Y C AS+ L + V+ +LV E TT+ +G + L
Sbjct: 1656 SPGEASSGLYSCVASSPAGEAVLQYSVE---VQVPPQLLVAEGLGQVTTI--VGQPLELP 1710
Query: 157 CSLNDSATEVTGHRWLKGGVVLKEDA---LPGQKTEFKVD--SDDQWGEYSCVFLPEPMG 211
C S + V +WL+ G +E A + Q T +D D G ++C E G
Sbjct: 1711 CQA--SGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNE-AG 1767
Query: 212 TA----NIQLHG 219
TA + +HG
Sbjct: 1768 TAGAEVEVSVHG 1779
Score = 31.2 bits (69), Expect = 1.6
Identities = 67/295 (22%), Positives = 93/295 (31%), Gaps = 59/295 (20%)
Query: 40 VELHCEAVGSPVPEIQWWFEGQG-PNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTL 98
V L CEA G P P I W EG +Q+ G +L H
Sbjct: 3965 VLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHAS---------------- 4008
Query: 99 VEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDL----GSKIL 154
ED G Y C A N + ++V P + + DL GS
Sbjct: 4009 -PEDAGNYLCIAKNSAGS-----------AMGKTRLVVQVPPVIENGLPDLSTTEGSHAF 4056
Query: 155 LTCSLNDSATEVTGHRWLKGGVVL-----KEDALPGQKTEFKVDSDDQWGEYSCVFLPEP 209
L C S W K G + K P + K G Y+C
Sbjct: 4057 LPCKARGSPE--PNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCT-AENA 4113
Query: 210 MGTANIQLHGP----PRVKAVKSSEHINEGETAMLVCKSESVP-PVTDWAWYKITDSEDK 264
+G A ++H P + + G+ L C + P P W D+
Sbjct: 4114 VGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT------VNDR 4167
Query: 265 ALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVR 319
+ G VS G S L ++ E D G Y C + G QA+ + V+
Sbjct: 4168 PVTEG------VSEQDGGSTLQRAAVSRE-DSGTYVCWAENRVGRTQAVSFVHVK 4215
Score = 30.8 bits (68), Expect = 2.1
Identities = 22/82 (26%), Positives = 33/82 (40%), Gaps = 31/82 (37%)
Query: 36 VGGSVELHCEAVGSPVPEIQW-----WFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAA 90
VG +++L+C A G+P P++ W +G+GP + VH A
Sbjct: 1133 VGEALDLNCVAEGNPEPQLSWSKDGVVLQGRGPQGS------------VHFAA------- 1173
Query: 91 STISIDTLVEEDTGTYECRASN 112
+ D G Y C ASN
Sbjct: 1174 -------IRTSDAGRYRCEASN 1188
Score = 30.4 bits (67), Expect = 2.8
Identities = 26/95 (27%), Positives = 37/95 (38%), Gaps = 24/95 (25%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQ--GPNDTCSQLWDGARLDRVHIHATYHQHAASTI 93
V ++ L CE+ P P I+W+ +GQ P+ L +G L
Sbjct: 2653 VNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLL----------------- 2695
Query: 94 SIDTLVEEDTGTYECRASN-----DPDRNHLTRAP 123
I D+G Y C A+N D D N L + P
Sbjct: 2696 QIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVP 2730
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 73.6 bits (179), Expect = 3e-13
Identities = 75/298 (25%), Positives = 128/298 (42%), Gaps = 63/298 (21%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G +EL C+A G+P P I W +GQ ++L + +R RV
Sbjct: 2228 GAPMELLCDAQGTPQPNITWHKDGQ----ALTRLENNSRATRV----------------- 2266
Query: 97 TLVEEDTGTYECRASNDPD------RNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLG 150
L D G Y C A + R + P + R V+ L PG
Sbjct: 2267 -LRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPG---------- 2315
Query: 151 SKILLTCSLN-DSATEVTGHRWLKGGVVLKEDALP-----GQKTEFKVDSDDQWGEYSCV 204
+++L CS+ + A ++T HR G+VL+EDA G+ + + S G+YSC
Sbjct: 2316 -QLVLECSVEAEPAPKITWHR---DGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCT 2371
Query: 205 FLPEPMGTA---NIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVP-PVTDWAWYKITD 260
T+ +++H P +++ + +++ +TA+L C+++ VP P+ W
Sbjct: 2372 ARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSW------- 2424
Query: 261 SEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRV 318
+D+ ++ RF + L I+ + + D G Y C ++S GSD+ LRV
Sbjct: 2425 RKDRVPLDPRSPRFEILP---EGSLRIQPV-LAQDAGHYLCLASNSAGSDRQGRDLRV 2478
Score = 58.5 bits (140), Expect = 1e-08
Identities = 72/301 (23%), Positives = 117/301 (38%), Gaps = 45/301 (14%)
Query: 29 PLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQH 88
P+++ SV L C A G P P++ W F+G P + W G +
Sbjct: 610 PVNKAVLENASVTLECLASGVPPPDVSW-FKGHQPVSS----WMGVTVSV---------- 654
Query: 89 AASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVED 148
+ I+ D G+Y C ASN L RV V + + PG V
Sbjct: 655 DGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVN-VPPRITLPPSLPGPVL----- 708
Query: 149 LGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQK--------TEFKVDSDDQWGE 200
+ + + LTC+ + + WLK G + PG + T + D G
Sbjct: 709 VNTPVRLTCNATGAPSPTL--MWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDS-GR 765
Query: 201 YSCVFLP---EPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYK 257
YSCV + E +Q+H PP + + + + E+ L C+S ++PP +W+K
Sbjct: 766 YSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPV-LSWWK 824
Query: 258 ITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLR 317
+ + L E R V S ++ L ++ ++ D G Y C + G + L
Sbjct: 825 ----DGRPL----EPRPGVHLSADKALLQVDRADV-WDAGHYTCEALNQAGHSEKHYNLN 875
Query: 318 V 318
V
Sbjct: 876 V 876
Score = 58.2 bits (139), Expect = 1e-08
Identities = 81/313 (25%), Positives = 108/313 (34%), Gaps = 51/313 (16%)
Query: 25 FVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHAT 84
F P + +G + L C A GSP P I W DR
Sbjct: 2849 FTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVN-----------------DRPVTEGV 2891
Query: 85 YHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFT 144
Q ST+ + ED+GTY C A N R VK +A VL G F+
Sbjct: 2892 SEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK----EAPVL---QGEAFS 2944
Query: 145 -TVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDAL-----PGQKTEFKVDSDDQW 198
VE +G I L C + V W+K G+ L+ L G T + + DD
Sbjct: 2945 YLVEPVGGSIQLDCVVR--GDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDA- 3001
Query: 199 GEYSCVFLPEPMGTAN----IQLHGPPRVKAVKSSEHINEGETAMLVCKSESVP-PVTDW 253
G Y C+ E MG A + L P + + G+ L C++ P P +W
Sbjct: 3002 GRYQCLAENE-MGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEW 3060
Query: 254 AWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAI 313
+ L R S L +EN+ D G Y C + GS A
Sbjct: 3061 L------QAGQPLRASRRLRTLPDGS-----LWLENVE-TGDAGTYDCVAHNLLGSATAR 3108
Query: 314 ITLRVRSHLAALW 326
L VR W
Sbjct: 3109 AFLVVRGEPQGSW 3121
Score = 56.6 bits (135), Expect = 4e-08
Identities = 77/309 (24%), Positives = 113/309 (36%), Gaps = 47/309 (15%)
Query: 25 FVQAPLSQQRWV----GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVH 80
F QAP Q V G L CE P P + W+ +GQ V
Sbjct: 1749 FRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQ---------------PLVL 1793
Query: 81 IHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPG 140
T + I D G Y C+ SN A R + Q P
Sbjct: 1794 AQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG-----EAVRTFTLTVQVPPTFENPK 1848
Query: 141 TVFTTVEDLGSKILLTCSLND-SATEVTGHRWLKGGVVLKEDAL-----PGQKTEFKVDS 194
T T + GS ++LTC ++ A VT WLK + ++ A+ G + +
Sbjct: 1849 TE-TVSQVAGSPLVLTCDVSGVPAPTVT---WLKDRMPVESSAVHGVVSRGGRLQLSRLQ 1904
Query: 195 DDQWGEYSCV---FLPEPMGTANIQLHGPPRVKA--VKSSEHINEGETAMLVCKSESVPP 249
Q G Y+CV E + + PR+++ V H+ EG+ L C+++ PP
Sbjct: 1905 PAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPP 1964
Query: 250 VTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGS 309
D AW K D G RF++ L ++ L +D G Y C + G
Sbjct: 1965 -PDVAWLK--DGSPLGQDMGPHLRFYLDG----GSLVLKGLR-ASDAGAYTCVAHNPAGE 2016
Query: 310 DQAIITLRV 318
D + T+ V
Sbjct: 2017 DARLHTVNV 2025
Score = 53.5 bits (127), Expect = 3e-07
Identities = 76/297 (25%), Positives = 110/297 (37%), Gaps = 55/297 (18%)
Query: 40 VELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLV 99
V L C + G P P + W G +QL GAR + Y + + I +
Sbjct: 2592 VVLTCHSTGIPAPTVSWSKAG-------AQL--GAR------GSGYRVSPSGALEIGQAL 2636
Query: 100 EEDTGTYECRASNDPDRNH----LTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILL 155
G Y C A N H LT V+A VV L P V E+ ++LL
Sbjct: 2637 PIHAGRYTCSARNSAGVAHKHVFLT-------VQASPVVKPL-PSVVRAVAEE---EVLL 2685
Query: 156 TCSLNDSATEVTGHRWLKGGV----VLKEDALPGQKTEFKVDSDDQWGEYSCV---FLPE 208
C + W K G+ + LPG + S + G Y C+
Sbjct: 2686 PCEASGIPRPTI--TWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGS 2743
Query: 209 PMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMN 268
MG + + PP ++ EG A L CK+ P IT +D ++
Sbjct: 2744 AMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEP------NITWDKDGQPVS 2797
Query: 269 GSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSHLAAL 325
G+E +F + S EL ++NL + D G Y C ++ A+ R R HL L
Sbjct: 2798 GAEGKFTIQPS---GELLVKNLEGQ-DAGTYTCT------AENAVGRARRRVHLTIL 2844
Score = 51.2 bits (121), Expect = 2e-06
Identities = 75/301 (24%), Positives = 112/301 (37%), Gaps = 44/301 (14%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQ---GPNDTCSQLWDGARLDRVHIHATYHQHAASTI 93
G S+ L C+A G PVPEI W + Q P WD +V H + ++
Sbjct: 33 GQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWD-LGWGQVGGHRLLDE--GQSL 89
Query: 94 SIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKI 153
+ E D+G Y CRA N A R + VL G + G+ +
Sbjct: 90 HFPRIQEGDSGLYSCRAENQAG-----TAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADV 144
Query: 154 LLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQ-----------WGEYS 202
L C + T W K ++ LPG +V D Q G Y
Sbjct: 145 ELQCWTSGVPTPQV--EWTKD----RQPVLPG-GPHLQVQEDGQVLRITGSHVGDEGRYQ 197
Query: 203 CV-FLPEPMGTANIQL--HGPPRVKAVKSSEH--INEGETAMLVCKSESVPPVTDWAWYK 257
CV F P + QL H PP + + + E L+C++ V P + W+K
Sbjct: 198 CVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGV-PTPNITWFK 256
Query: 258 ITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLR 317
D AL+ S V ++G +L + +D G Y C +++ G+ + L
Sbjct: 257 -----DGALLPTSTK---VVYTRGGRQLQLGRA-QSSDAGVYTCKASNAVGAAEKATRLD 307
Query: 318 V 318
V
Sbjct: 308 V 308
Score = 46.6 bits (109), Expect = 4e-05
Identities = 66/301 (21%), Positives = 108/301 (35%), Gaps = 69/301 (22%)
Query: 42 LHCEAVGSPVPEIQWWFEGQ--GPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLV 99
L+C+ P P++ W+ E Q D S L G + I +
Sbjct: 1488 LYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGG-----------------RVLQIPLVR 1530
Query: 100 EEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCSL 159
E+ G Y C+ASN+ + W+ + +LVL P + E+L ++ + S
Sbjct: 1531 AENAGRYSCKASNEVGED---------WLHYE--LLVLTPPVILGDTEELVEEVTVNASS 1579
Query: 160 NDS------ATEVTGHRWLKGGVVLKEDAL-----PGQKTEFKVDSDDQWGEYSCVF--- 205
S V WL+ G+ GQ + Y CV
Sbjct: 1580 TVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQ 1639
Query: 206 --LPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVP------PVTDWAWYK 257
E + T +Q+ PPR+ ++ + ++ S S+P P + WYK
Sbjct: 1640 AGSAEKLFTLRVQV--PPRIAG------LDLEQVTAILNSSVSLPCDVHAHPNPEVTWYK 1691
Query: 258 ITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLR 317
+ +AL G E V G L + + +D G Y C ++ G DQ ++ L
Sbjct: 1692 ----DSQALSLGEE----VFLLPGTHTLQLGRARL-SDSGMYTCEALNAAGRDQKLVQLS 1742
Query: 318 V 318
V
Sbjct: 1743 V 1743
Score = 45.8 bits (107), Expect = 6e-05
Identities = 75/301 (24%), Positives = 108/301 (35%), Gaps = 61/301 (20%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDR-VHIHATYHQHAASTISI 95
G V L CEA G P P++ W L DG+ L + + H ++ S + +
Sbjct: 1950 GQEVRLDCEADGQPPPDVAW-------------LKDGSPLGQDMGPHLRFYLDGGSLV-L 1995
Query: 96 DTLVEEDTGTYECRASN---DPDRNHLTRA---PRVKWVRAQAVVLVLEPGTVFTTVEDL 149
L D G Y C A N + R H P +K + LV PG + T V
Sbjct: 1996 KGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMV--- 2052
Query: 150 GSKILLTCSLNDSATEVTGHRWLKGGVVL---KEDALPGQKTEFKVDSDD--QWGEYSCV 204
C + S WLK G+ L + L G ++ G ++CV
Sbjct: 2053 -------CPVRGSPPIHVS--WLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCV 2103
Query: 205 FLPEPMGTAN----IQLHGPPRVKAVKSSEH--INEGETAMLVCKSESVP-PVTDWAWYK 257
P G A+ +Q+ PP ++ V+ + G L C++ VP P+ W
Sbjct: 2104 -AASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSW---- 2158
Query: 258 ITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLR 317
M E S QG S L +E + D G Y C S G + L
Sbjct: 2159 ---------MKDGEPLLSQSLEQGPS-LQLEAVG-AGDSGTYSCVAVSEAGEARRHFQLT 2207
Query: 318 V 318
V
Sbjct: 2208 V 2208
Score = 45.4 bits (106), Expect = 8e-05
Identities = 74/301 (24%), Positives = 114/301 (37%), Gaps = 48/301 (15%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
VG +EL C+A GSPVP IQW G+ + L V + + +T+ I
Sbjct: 421 VGQPLELPCQASGSPVPTIQWLQNGRPAEE----------LAGVQVAS-----QGTTLHI 465
Query: 96 DTLVEEDTGTYECRASNDPDRN--------HLTRAPRVKWVRAQAVVLVLEPGTVFTTVE 147
D + + +G + C+A+N+ H AP V V E + F
Sbjct: 466 DHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAAC 525
Query: 148 DLGSKILLTCSLNDSATEVTGHRWLKGGVVLKED-------ALPGQKTEFKVDSDDQWGE 200
D + + V G W G + E +LP KVD D+ G
Sbjct: 526 D--PPVHRGWGAHPKPPLVEG--WCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDE-GI 580
Query: 201 YSCV---FLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYK 257
Y+C E +++ PP ++ ++ + E + L C + VPP D +W+K
Sbjct: 581 YTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPP-PDVSWFK 639
Query: 258 ITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLR 317
S V+ S L IE + +D G YRC ++ GS + LR
Sbjct: 640 GHQP--------VSSWMGVTVSVDGRVLRIEQAQL-SDAGSYRCVASNVAGSTELRYGLR 690
Query: 318 V 318
V
Sbjct: 691 V 691
Score = 44.3 bits (103), Expect = 2e-04
Identities = 62/278 (22%), Positives = 98/278 (35%), Gaps = 45/278 (16%)
Query: 42 LHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLVEE 101
L CEA GSP P + WW +GQ +LD Y ++ + + +
Sbjct: 2501 LPCEASGSPKPLVVWWKDGQ-------------KLDFRLQQGAYRLLPSNALLLTAPGPQ 2547
Query: 102 DTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCSLND 161
D+ +EC SN+ H R+ V + + T FT + + ++LTC +
Sbjct: 2548 DSAQFECVVSNEVGEAH-----RLYQVTVHVPPTIADDQTDFTVT--MMAPVVLTC--HS 2598
Query: 162 SATEVTGHRWLKGGVVLKE-----DALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTAN-- 214
+ W K G L P E G Y+C G A+
Sbjct: 2599 TGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTC-SARNSAGVAHKH 2657
Query: 215 --IQLHGPPRVKAVKSSEHINEGETAMLVCKSESVP-PVTDWAWYKITDSEDKALMNGSE 271
+ + P VK + S E +L C++ +P P W E + G
Sbjct: 2658 VFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITW------QKEGLNVATGVS 2711
Query: 272 SRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGS 309
++ +L I + + E D G Y C +S GS
Sbjct: 2712 TQVLPG-----GQLRIAHASPE-DAGNYLCIAKNSAGS 2743
Score = 42.4 bits (98), Expect = 7e-04
Identities = 71/296 (23%), Positives = 110/296 (37%), Gaps = 51/296 (17%)
Query: 39 SVELHCEAVGSPVPEIQWWFEGQ--GPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
+V L C A+G+PVP I W G P+ L DG + +
Sbjct: 1580 TVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDG-----------------QVLQVS 1622
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLT 156
T D +Y C A N RV+ V + L LE T L S + L
Sbjct: 1623 TAEVADAASYMCVAENQAGSAEKLFTLRVQ-VPPRIAGLDLEQVTAI-----LNSSVSLP 1676
Query: 157 CSLNDSAT-EVTGHRWLKGGVVLK--EDA--LPGQKT-EFKVDSDDQWGEYSCVFL---P 207
C ++ EVT W K L E+ LPG T + G Y+C L
Sbjct: 1677 CDVHAHPNPEVT---WYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAG 1733
Query: 208 EPMGTANIQLHGPPRVKAV----KSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSED 263
+ + PP + + + + G+ A+L C+++++P T WYK D +
Sbjct: 1734 RDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPT-VTWYK--DGQP 1790
Query: 264 KALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVR 319
L ++ + +G L I+ + +D G Y C ++ G TL V+
Sbjct: 1791 LVLAQRTQ------ALRGGQRLEIQEAQV-SDKGLYSCKVSNVAGEAVRTFTLTVQ 1839
Score = 37.4 bits (85), Expect = 0.023
Identities = 59/255 (23%), Positives = 88/255 (34%), Gaps = 40/255 (15%)
Query: 14 LGTHGASGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDG 73
L H AG + P G L C A G P P + W +GQ G
Sbjct: 968 LEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPV---------G 1018
Query: 74 ARLDRVHIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAV 133
A L Q+ ++ ++ TG Y C A N R R + + +
Sbjct: 1019 AEL------GLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGR--AERKFELSVLVPPEL 1070
Query: 134 VLVLEPGTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKT----- 188
+ L+P T T L S + L C RW +G +E PG+ T
Sbjct: 1071 IGDLDPLTNITAA--LHSPLTLLCEA--MGIPPPAIRWFRG----EEPVSPGEDTYLLAG 1122
Query: 189 ----EFKVDSDDQWGEYSCVF---LPEPMGTANIQLHGPPRVKAVKSSEHIN--EGETAM 239
+ + G YSC+ E ++++ PP ++ E I +G+TA
Sbjct: 1123 GWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAH 1182
Query: 240 LVCKSESVP-PVTDW 253
L+C P P W
Sbjct: 1183 LMCNVTGHPQPKLTW 1197
Score = 37.4 bits (85), Expect = 0.023
Identities = 66/300 (22%), Positives = 101/300 (33%), Gaps = 65/300 (21%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G VEL CEA G P+P + W +G+ SQ + ++ ++
Sbjct: 2139 GSLVELPCEARGVPLPLVSWMKDGE---PLLSQSLE----------------QGPSLQLE 2179
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLT 156
+ D+GTY C A ++ R + V+EP +ED G L+
Sbjct: 2180 AVGAGDSGTYSCVAVSEAGE-----------ARRHFQLTVMEP----PHIEDSGQPTELS 2224
Query: 157 CS--------LNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVFLPE 208
+ + T W K G L L +V G Y+C+
Sbjct: 2225 LTPGAPMELLCDAQGTPQPNITWHKDGQALTR--LENNSRATRVLRVRDAGLYTCL-AES 2281
Query: 209 PMGTAN----IQLHGPPRVKAVKSSEHINEGETAMLV--CKSESVP-PVTDWAWYKITDS 261
P G +++ PP + + + LV C E+ P P W I
Sbjct: 2282 PAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQ 2341
Query: 262 EDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSH 321
ED RF L ++ L+ AD G Y C ++ GS + RV H
Sbjct: 2342 EDAHTQFPERGRF----------LQLQALST-ADSGDYSCTARNAAGSTS--VAFRVEIH 2388
Score = 37.4 bits (85), Expect = 0.023
Identities = 38/137 (27%), Positives = 52/137 (37%), Gaps = 32/137 (23%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G L C+A GSP P I W +GQ + + + + +
Sbjct: 2770 GSHAFLPCKARGSPEPNITWDKDGQPVSGA---------------EGKFTIQPSGELLVK 2814
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVED-----LGS 151
L +D GTY C A N + RA R R +LVL VFTT+ LG
Sbjct: 2815 NLEGQDAGTYTCTA-----ENAVGRARR----RVHLTILVL---PVFTTLPGDRSLRLGD 2862
Query: 152 KILLTCSLNDSATEVTG 168
++ L C+ S T G
Sbjct: 2863 RLWLRCAARGSPTPRIG 2879
Score = 35.0 bits (79), Expect = 0.11
Identities = 60/252 (23%), Positives = 95/252 (37%), Gaps = 40/252 (15%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
+ SV L C+ P PE+ W+ + Q + + V + H T+ +
Sbjct: 1669 LNSSVSLPCDVHAHPNPEVTWYKDSQAL----------SLGEEVFLLPGTH-----TLQL 1713
Query: 96 DTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVV----LVLEPGTVFTTVEDLGS 151
D+G Y C A N R+ K V+ +V G + +G
Sbjct: 1714 GRARLSDSGMYTCEALNAAGRDQ-------KLVQLSVLVPPAFRQAPRGPQDAVLVRVGD 1766
Query: 152 KILLTCSLNDSATEVTGHRWLKGGVVL----KEDAL-PGQKTEFKVDSDDQWGEYSCV-- 204
K +L+C D+ E T W K G L + AL GQ+ E + G YSC
Sbjct: 1767 KAVLSCE-TDALPEPT-VTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVS 1824
Query: 205 -FLPEPMGTANIQLHGPPRVKAVKSSEHINE--GETAMLVCKSESVPPVTDWAWYKITDS 261
E + T + + PP + K +E +++ G +L C VP T W K
Sbjct: 1825 NVAGEAVRTFTLTVQVPPTFENPK-TETVSQVAGSPLVLTCDVSGVPAPT-VTWLKDRMP 1882
Query: 262 EDKALMNGSESR 273
+ + ++G SR
Sbjct: 1883 VESSAVHGVVSR 1894
Score = 33.9 bits (76), Expect = 0.25
Identities = 70/294 (23%), Positives = 112/294 (38%), Gaps = 54/294 (18%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G + L C G P P++ W+ +G+ AR D HI + +
Sbjct: 1178 GQTAHLMCNVTGHPQPKLTWFKDGR----------PLARGDAHHISPD-----GVLLQVL 1222
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLT 156
G Y C A+N T+ ++ + A ++ E + + I L
Sbjct: 1223 QANLSSAGHYSCIAANAVGEK--TKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLI 1280
Query: 157 C-SLNDSATEVTGHRWLKGGVVLKE----DALPG-QKTEFKVDSDDQWGEYSCVF---LP 207
C +L + +T W+K G + LPG + + G+Y+CV L
Sbjct: 1281 CEALAFPSPNIT---WMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELG 1337
Query: 208 EPMGTANIQLHGPPR-----------VKAVKSSEHINEGETAMLVCKSESVPPVTDWAWY 256
E + ++++ PP VK VK+ + T L C+S +VPP T WY
Sbjct: 1338 EAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVN----STLTLECESWAVPPPT-IRWY 1392
Query: 257 KITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSD 310
K D + SR V +GR L I+ + +D G+Y C T+ G D
Sbjct: 1393 K--DGQPVT----PSSRLQV-LGEGRL-LQIQPTQV-SDSGRYLCVATNVAGED 1437
Score = 32.3 bits (72), Expect = 0.74
Identities = 48/192 (25%), Positives = 74/192 (38%), Gaps = 32/192 (16%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G V L C A G P P + W EG L + + + S + ++
Sbjct: 329 GRPVALECVARGHPSPTLSWHHEG---------------LPVAESNESRLETDGSVLRLE 373
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLT 156
+ E +G Y C AS+ L + V+ +LV E TT+ +G + L
Sbjct: 374 SPGEASSGLYSCVASSPAGEAVLQYSVE---VQVPPQLLVAEGLGQVTTI--VGQPLELP 428
Query: 157 CSLNDSATEVTGHRWLKGGVVLKEDA---LPGQKTEFKVD--SDDQWGEYSCVFLPEPMG 211
C S + V +WL+ G +E A + Q T +D D G ++C E G
Sbjct: 429 CQA--SGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNE-AG 485
Query: 212 TA----NIQLHG 219
TA + +HG
Sbjct: 486 TAGAEVEVSVHG 497
Score = 31.2 bits (69), Expect = 1.6
Identities = 67/295 (22%), Positives = 93/295 (31%), Gaps = 59/295 (20%)
Query: 40 VELHCEAVGSPVPEIQWWFEGQG-PNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTL 98
V L CEA G P P I W EG +Q+ G +L H
Sbjct: 2683 VLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHAS---------------- 2726
Query: 99 VEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDL----GSKIL 154
ED G Y C A N + ++V P + + DL GS
Sbjct: 2727 -PEDAGNYLCIAKNSAGS-----------AMGKTRLVVQVPPVIENGLPDLSTTEGSHAF 2774
Query: 155 LTCSLNDSATEVTGHRWLKGGVVL-----KEDALPGQKTEFKVDSDDQWGEYSCVFLPEP 209
L C S W K G + K P + K G Y+C
Sbjct: 2775 LPCKARGSPE--PNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCT-AENA 2831
Query: 210 MGTANIQLHGP----PRVKAVKSSEHINEGETAMLVCKSESVP-PVTDWAWYKITDSEDK 264
+G A ++H P + + G+ L C + P P W D+
Sbjct: 2832 VGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT------VNDR 2885
Query: 265 ALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVR 319
+ G VS G S L ++ E D G Y C + G QA+ + V+
Sbjct: 2886 PVTEG------VSEQDGGSTLQRAAVSRE-DSGTYVCWAENRVGRTQAVSFVHVK 2933
Score = 30.4 bits (67), Expect = 2.8
Identities = 26/95 (27%), Positives = 37/95 (38%), Gaps = 24/95 (25%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQ--GPNDTCSQLWDGARLDRVHIHATYHQHAASTI 93
V ++ L CE+ P P I+W+ +GQ P+ L +G L
Sbjct: 1371 VNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLL----------------- 1413
Query: 94 SIDTLVEEDTGTYECRASN-----DPDRNHLTRAP 123
I D+G Y C A+N D D N L + P
Sbjct: 1414 QIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVP 1448
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 73.2 bits (178), Expect = 4e-13
Identities = 78/305 (25%), Positives = 128/305 (41%), Gaps = 51/305 (16%)
Query: 31 SQQRWVGGSVELHCEAVGSPVPEIQWWFEGQG-PNDTCSQLWDGARLDRVHIHATYHQHA 89
SQ+ W G +VEL C A G P+P I+W +G+ P D+ W
Sbjct: 294 SQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADS---RW---------------TKR 335
Query: 90 ASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDL 149
+ ++I L ED+GTY C +N A +++V++P V T + L
Sbjct: 336 ITGLTISDLRTEDSGTYICEVTN-----------TFGSAEATGILMVIDPLHVTLTPKKL 384
Query: 150 ----GSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALP--GQKTEFKVDSDDQ---WGE 200
GS ++L+C+L S E T + +VL ++A+ G E + + Q G
Sbjct: 385 KTGIGSTVILSCALTGS-PEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGA 443
Query: 201 YSCVFLPEPMGTANIQL----HGPPRVKAVKSSEHINEGETAMLVCKSESVPPVT-DWAW 255
Y C + + + G PR+ + S + +N GE L+C ++ PP T WA
Sbjct: 444 YQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWAL 503
Query: 256 YKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNME-ADPGQYRCNGTSSKGSDQAII 314
++ + +GS + S G + H+ + D G YRC + GS +
Sbjct: 504 -----DDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQA 558
Query: 315 TLRVR 319
+ VR
Sbjct: 559 RINVR 563
Score = 36.6 bits (83), Expect = 0.039
Identities = 74/307 (24%), Positives = 124/307 (40%), Gaps = 66/307 (21%)
Query: 40 VELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLV 99
V + C A GSP ++W+ T ++D + VH + T + S + ++ +
Sbjct: 103 VVVPCPAAGSPSAALRWYLA------TGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFI 156
Query: 100 EEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGS-------- 151
++ Y C A N + R+P +R +AV EP TV VED S
Sbjct: 157 HDN--DYFCTAENAAGK---IRSPN---IRVKAV--FREPYTV--RVEDQRSMRGNVAVF 204
Query: 152 KILLTCSL----------NDSATEVTGHRWL---KGGV----VLKEDALPGQK--TEFKV 192
K L+ S+ D+ + + HR+ GG+ V KEDAL + T+ K
Sbjct: 205 KCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKY 264
Query: 193 DSDDQWGEYSCVFLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVP-PVT 251
+ + + + + +P + L G S+ + G T L C + P P
Sbjct: 265 SGETRQSNGARLSVTDPAESIPTILDG-------FHSQEVWAGHTVELPCTASGYPIPAI 317
Query: 252 DWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQ 311
W + + L ++SR+ ++ + L I +L E D G Y C T++ GS +
Sbjct: 318 RWL------KDGRPL--PADSRW----TKRITGLTISDLRTE-DSGTYICEVTNTFGSAE 364
Query: 312 AIITLRV 318
A L V
Sbjct: 365 ATGILMV 371
Score = 35.4 bits (80), Expect = 0.087
Identities = 22/73 (30%), Positives = 32/73 (43%), Gaps = 12/73 (16%)
Query: 40 VELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLV 99
V L C +VG P P ++W + + S DG RL H T+ + +
Sbjct: 1367 VRLPCNSVGDPAPAVKWTKDSEDSAIPVSM--DGHRL----------IHTNGTLLLRAVK 1414
Query: 100 EEDTGTYECRASN 112
ED+G Y C A+N
Sbjct: 1415 AEDSGYYTCTATN 1427
Score = 33.1 bits (74), Expect = 0.43
Identities = 40/172 (23%), Positives = 64/172 (37%), Gaps = 16/172 (9%)
Query: 25 FVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHAT 84
FV P +Q G + L+C G P P++ W N Q R+ I
Sbjct: 752 FVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNP--QQYHPVPLTGRIQILPN 809
Query: 85 YHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFT 144
S++ I ++EED G Y C+ASN T + ++ + ++ T
Sbjct: 810 ------SSLLIRHVLEEDIGYYLCQASNGVG----TDISKSMFLTVKIPAMITSHPN--T 857
Query: 145 TVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDD 196
T+ G L C+ + RW KG V+ D + K + D+
Sbjct: 858 TIAIKGHAKELNCTARGERPIII--RWEKGDTVIDPDRVMRYAIATKDNGDE 907
>gi|38348215 embigin [Homo sapiens]
Length = 327
Score = 67.4 bits (163), Expect = 2e-11
Identities = 66/216 (30%), Positives = 96/216 (44%), Gaps = 33/216 (15%)
Query: 151 SKILLTCSLNDS----ATEVTGHRWLKGGVVLKEDALPGQ-------KTEFKVDSDDQWG 199
S + LTC S A VT W K G L+ + L + F + + Q G
Sbjct: 82 SNVNLTCQFTTSGDLNAVNVT---WKKDGEQLENNYLVSATGSTLYTQYRFTIINSKQMG 138
Query: 200 EYSCVFLPEP--MGTANI---QLHGP--PRVKAVKSSEHINEGETAMLVCKSESVPPVTD 252
YSC F E GT N +LHG P + V G++ +L CK ++ P+ +
Sbjct: 139 SYSCFFREEKEQRGTFNFKVPELHGKNKPLISYV--------GDSTVLTCKCQNCFPL-N 189
Query: 253 WAWYKITDSEDKALMNGSESRFFVSSSQGR-SELHIENLNMEADPGQYRCNGTSSKGSDQ 311
W WY S K + +++ ++ + ++L I L +E D Y C G +
Sbjct: 190 WTWYSSNGSV-KVPVGVQMNKYVINGTYANETKLKITQL-LEEDGESYWCRALFQLGESE 247
Query: 312 AIITLRVRSHLAALWPFLGIVAEVLVLVTIIFIYEK 347
I L V S+L L PFL IVAEV++LV I + EK
Sbjct: 248 EHIELVVLSYLVPLKPFLVIVAEVILLVATILLCEK 283
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 63.2 bits (152), Expect = 4e-10
Identities = 65/290 (22%), Positives = 114/290 (39%), Gaps = 53/290 (18%)
Query: 42 LHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHA---ASTISIDTL 98
L CEA G+P P I W EG ++++ + HA + + I
Sbjct: 4007 LPCEATGTPSPFITWQKEG------------------INVNTSGRNHAVLPSGGLQISRA 4048
Query: 99 VEEDTGTYECRASNDPD------RNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSK 152
V ED GTY C A N + ++ P + + V+ V +P T+ + L
Sbjct: 4049 VREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPP 4108
Query: 153 ILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCV---FLPEP 209
+ + E R L G + PG G Y+C+
Sbjct: 4109 DITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDA-----------GHYTCMAANVAGSS 4157
Query: 210 MGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVP-PVTDWAWYKITDSEDKALMN 268
+ + +H PPR+++ + +NE A+L C ++ +P P +W +D L+
Sbjct: 4158 STSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINW-------KKDNVLLA 4210
Query: 269 GSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRV 318
++ +++ EL +EN+ +E D G Y C ++ G D ++L V
Sbjct: 4211 NLLGKY---TAEPYGELILENVVLE-DSGFYTCVANNAAGEDTHTVSLTV 4256
Score = 60.1 bits (144), Expect = 3e-09
Identities = 73/292 (25%), Positives = 123/292 (42%), Gaps = 42/292 (14%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
V +EL C A G P P++ W +G+ T D+V + I
Sbjct: 3542 VNNPLELTCIASGIPAPKMTWMKDGRPLPQT----------DQVQTLG-----GGEVLRI 3586
Query: 96 DTLVEEDTGTYECRASN---DPDRNHLTRA---PRVKWVRAQAVVLVLEPGTV-FTTVED 148
T EDTG Y C AS+ D D+ +L R P + + VL V D
Sbjct: 3587 STAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSD 3646
Query: 149 LGSKILLTCSLNDSATEVTGH-RWLKGGVVLK-EDALPGQKTEFKVDSDDQWGEYSCVFL 206
++T N + T R L GG L+ +A G + + + G+ + F+
Sbjct: 3647 AVPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFI 3706
Query: 207 PEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKAL 266
+ ++ PP +K S I ++ +L C +E VP +IT +D A+
Sbjct: 3707 --------LTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTP------RITWRKDGAV 3752
Query: 267 MNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRV 318
+ G+ +R+ + + LHI++ ++ D G+Y C T++ G+D+ I L+V
Sbjct: 3753 LAGNHARYSILEN---GFLHIQSAHV-TDTGRYLCMATNAAGTDRRRIDLQV 3800
Score = 58.2 bits (139), Expect = 1e-08
Identities = 67/292 (22%), Positives = 117/292 (40%), Gaps = 45/292 (15%)
Query: 30 LSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHA 89
L++ V V+L C+A G+PVP I W+ + + + + S + L+R I
Sbjct: 1928 LNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTF----LNRGQI-------- 1975
Query: 90 ASTISIDTLVEEDTGTYECRASNDPDRNHLTR------APRVKWVRAQAVVLVLEPGTVF 143
I I++ D G Y+C A N L AP + V+V P +
Sbjct: 1976 ---IDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLE 2032
Query: 144 TTVEDLGSKILLTCSLNDSATEVT-GHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYS 202
+ + L + + G + L GG +L + T G Y+
Sbjct: 2033 CEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDT----------GRYT 2082
Query: 203 CVFL---PEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKIT 259
CV + E +++++ PP + + + + + L+C+S+++PP T W K
Sbjct: 2083 CVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPT-LTWLK-- 2139
Query: 260 DSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQ 311
D G +S S+ RS L IE+ ++ D G+Y C T+ G +
Sbjct: 2140 DGHPLLKKPG------LSISENRSVLKIEDAQVQ-DTGRYTCEATNVAGKTE 2184
Score = 56.6 bits (135), Expect = 4e-08
Identities = 70/300 (23%), Positives = 118/300 (39%), Gaps = 59/300 (19%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G + L C+A G P+P++ W F N+ A D V+ H S + I+
Sbjct: 4274 GEQLRLSCKATGIPLPKLTWTFN----NNIIP-----AHFDSVNGH--------SELVIE 4316
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVF------TTVEDLG 150
+ +ED+GTY C A N V +V+A V V EP VF +E LG
Sbjct: 4317 RVSKEDSGTYVCTAENS-----------VGFVKAIGFVYVKEP-PVFKGDYPSNWIEPLG 4364
Query: 151 SKILLTCSLNDSATEVTGHRWLKGGVVLK-----EDALPGQKTEFKVDSDDQWGEYSCVF 205
+L C + T +W + GV ++ G + ++D G+Y+CV
Sbjct: 4365 GNAILNCEVKGDPTPTI--QWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDA-GDYTCVA 4421
Query: 206 LPEP---MGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVP-PVTDWAWYKITDS 261
E + ++ L PP + IN G +L C++ P P W+ + S
Sbjct: 4422 TNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSIS 4481
Query: 262 EDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSH 321
D + S + +++ +Q + D ++ C + GS + + V+ H
Sbjct: 4482 WDDRVNVLSNNSLYIADAQ------------KEDTSEFECVARNLMGSVLVRVPVIVQVH 4529
Score = 53.5 bits (127), Expect = 3e-07
Identities = 73/302 (24%), Positives = 109/302 (36%), Gaps = 59/302 (19%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G SV L CE+ P P I W+ G+ ++ V I A + I
Sbjct: 3074 GTSVSLECESNAVPPPVITWYKNGRMITES----------THVEILAD-----GQMLHIK 3118
Query: 97 TLVEEDTGTYECRASN----DPDRNHLT--RAPRVKWVRAQAVVLVLEPGTVFTTVEDLG 150
DTG Y CRA N D HL P ++ + + VE +
Sbjct: 3119 KAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVI------------VETIS 3166
Query: 151 SKILLTCSLNDSATEVTGHRWLKGGV-VLKEDALP------GQKTEFKVDSDDQWGEYSC 203
+ + LTC WLK + D+L G K + G Y+C
Sbjct: 3167 NPVTLTCDATGIPPPTIA--WLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTC 3224
Query: 204 VFLPEPMGTAN----IQLHGPPRVKA--VKSSEHINEGETAMLVCKSESVP-PVTDWAWY 256
+ G A + + PP V + S + GE LVC + +P P+ W
Sbjct: 3225 I-ASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWL-- 3281
Query: 257 KITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITL 316
+ K + +G R VS++ S L+I + +D G+Y C T+ G + I L
Sbjct: 3282 ----KDGKPIASGETERIRVSAN--GSTLNIYGA-LTSDTGKYTCVATNPAGEEDRIFNL 3334
Query: 317 RV 318
V
Sbjct: 3335 NV 3336
Score = 52.4 bits (124), Expect = 7e-07
Identities = 71/309 (22%), Positives = 122/309 (39%), Gaps = 50/309 (16%)
Query: 25 FVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIH-- 82
F+Q P +G +V L C G P P I+W RLD + I
Sbjct: 795 FIQEPADVSMEIGSNVTLPCYVQGYPEPTIKW-----------------RRLDNMPIFSR 837
Query: 83 ----ATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLE 138
++ Q + I L D GTY C A N + + V A ++ +
Sbjct: 838 PFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGK--IQSETTVTVTGLVAPLIGIS 895
Query: 139 PGTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSD--- 195
P +V +E G ++ L C+L + + RW+K +L ++ +++ + +
Sbjct: 896 P-SVANVIE--GQQLTLPCTLL-AGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQ 951
Query: 196 -DQWGEYSCVFLPEPMGTAN----IQLHGPPRVKAVKSSEHINEGETAMLVCKSESVP-P 249
GEY+CV GT N + +H P ++ + EG L CK+ P P
Sbjct: 952 LQDGGEYTCV-ASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKP 1010
Query: 250 VTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGS 309
W S+ L++ S ++F S+ L++ + E + G+Y C T++ G
Sbjct: 1011 SVIW-------SKKGELISTSSAKF---SAGADGSLYVVSPGGE-ESGEYVCTATNTAGY 1059
Query: 310 DQAIITLRV 318
+ + L V
Sbjct: 1060 AKRKVQLTV 1068
Score = 51.2 bits (121), Expect = 2e-06
Identities = 74/311 (23%), Positives = 116/311 (37%), Gaps = 57/311 (18%)
Query: 39 SVELHCEAVGSPVPEIQWWFEGQG-PNDTCSQLWDGARLDRVHIHATYHQHAASTISIDT 97
SV L CE G+PVPEI W +GQ D + G R + I
Sbjct: 2496 SVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRF----------------LQITN 2539
Query: 98 LVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTC 157
+ TG Y C AS+ H +R+ + + + V G L S L C
Sbjct: 2540 VQVPHTGRYTCLASS--PAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVC 2597
Query: 158 SLNDSATEVTGHRWLKGGVVLKED----ALPGQKT-EFKVDSDDQWGEYSCVFLPEP--- 209
W K G L+ + LPG +T + +D G YSCV E
Sbjct: 2598 EAYSYPPATI--TWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEM 2655
Query: 210 MGTANIQLHGPPRV------------KAVKSSEHINEGETAMLVCKSESVPPVTDWAWYK 257
+ ++++ PP + K VK I T L C++ ++P + +WYK
Sbjct: 2656 IKHYEVKVYIPPIINKGDLWGPGLSPKEVK----IKVNNTLTLECEAYAIPSAS-LSWYK 2710
Query: 258 ITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQA--IIT 315
D + +S V+ + L I+ + +D G+Y C ++ G D+ +
Sbjct: 2711 --DGQP------LKSDDHVNIAANGHTLQIKEAQI-SDTGRYTCVASNIAGEDELDFDVN 2761
Query: 316 LRVRSHLAALW 326
++V LW
Sbjct: 2762 IQVPPSFQKLW 2772
Score = 50.1 bits (118), Expect = 3e-06
Identities = 75/308 (24%), Positives = 117/308 (37%), Gaps = 68/308 (22%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
VG V++ C A G+P+P I W G + L DG H+ + T+SI
Sbjct: 1184 VGQRVDIPCNAQGTPLPVITWSKGGS------TMLVDGEH----HV-----SNPDGTLSI 1228
Query: 96 DTLVEEDTGTYECRASN--DPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGS-K 152
D D G Y C A+N D +T V+ V LEP T E + + +
Sbjct: 1229 DQATPSDAGIYTCVATNIAGTDETEIT-----LHVQEPPTVEDLEPPYNTTFQERVANQR 1283
Query: 153 ILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQW-----------GEY 201
I C T +WL G L G++ + D GEY
Sbjct: 1284 IEFPCPA--KGTPKPTIKWLHNG-----RELTGREPGISILEDGTLLVIASVTPYDNGEY 1336
Query: 202 SCVFLPEPMGTA---NIQLHGPPRVKAVKSSEHINE--GETAMLVCKSESVP-PVTDWAW 255
CV + E T N+++H PP +K + +++ + L C+ E P P+ W
Sbjct: 1337 ICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPII--MW 1394
Query: 256 YK----ITDSED-KALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSD 310
YK +T+S + + NG + F ++ + D G+Y C + G+
Sbjct: 1395 YKDNVQVTESSTIQTVNNGKILKLFRATPE--------------DAGRYSCKAINIAGTS 1440
Query: 311 QAIITLRV 318
Q + V
Sbjct: 1441 QKYFNIDV 1448
Score = 49.3 bits (116), Expect = 6e-06
Identities = 69/290 (23%), Positives = 107/290 (36%), Gaps = 61/290 (21%)
Query: 40 VELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLV 99
+ L CEA G P P+I W +G+ ++ Q ++ ++ I +
Sbjct: 4096 ITLSCEADGLPPPDITWHKDGRAIVESIRQ----------------RVLSSGSLQIAFVQ 4139
Query: 100 EEDTGTYECRASNDPDRNHLTR------APRVKWVRAQAVVLVLEPGTVFTTVEDLGSKI 153
D G Y C A+N + + PR++ V + S+
Sbjct: 4140 PGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTV-------------NENSQA 4186
Query: 154 LLTCSLNDSATEVTGHRWLKGGVVL-----KEDALP-GQKTEFKVDSDDQWGEYSCV--- 204
+L C + T W K V+L K A P G+ V +D G Y+CV
Sbjct: 4187 ILPCVADGIPTPAI--NWKKDNVLLANLLGKYTAEPYGELILENVVLEDS-GFYTCVANN 4243
Query: 205 FLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVP-PVTDWAWYKITDSED 263
E T ++ +H P + +N+GE L CK+ +P P W +
Sbjct: 4244 AAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTF-------- 4295
Query: 264 KALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAI 313
N + S G SEL IE ++ E D G Y C +S G +AI
Sbjct: 4296 ----NNNIIPAHFDSVNGHSELVIERVSKE-DSGTYVCTAENSVGFVKAI 4340
Score = 48.5 bits (114), Expect = 1e-05
Identities = 73/309 (23%), Positives = 121/309 (39%), Gaps = 50/309 (16%)
Query: 24 GFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHA 83
G + PL++Q + S+ L C+A G+P P + W +G D + I A
Sbjct: 1643 GNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKAN----------DNIRIEA 1692
Query: 84 TYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVF 143
+ I + E D G Y C A++ + +K+ V +E G
Sbjct: 1693 -----GGKKLEIMSAQEIDRGQYICVATS------VAGEKEIKYEVDVLVPPAIEGG--- 1738
Query: 144 TTVEDLGSKILLTCSLNDSATEVTGH-----RWLKGGVVLKED-----ALPGQKTEFKVD 193
++ I++ +L + VTG WLK G ++ E L G+K
Sbjct: 1739 ---DETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQA 1795
Query: 194 SDDQWGEYSCV---FLPEPMGTANIQLHGPPRVKAVKSSEH-INEGETAMLVCKSESVPP 249
G Y C+ + + +H PP +K+ SE + + + L C + +P
Sbjct: 1796 QVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPN 1855
Query: 250 VTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGS 309
+ IT +D +N ++ + SS GR L I +E D G+Y C T++ G
Sbjct: 1856 PS------ITWLKDDQPVNTAQGNLKIQSS-GR-VLQIAKTLLE-DAGRYTCVATNAAGE 1906
Query: 310 DQAIITLRV 318
Q I L V
Sbjct: 1907 TQQHIQLHV 1915
Score = 47.8 bits (112), Expect = 2e-05
Identities = 90/350 (25%), Positives = 133/350 (38%), Gaps = 70/350 (20%)
Query: 13 LLGTHGASGAAGF---VQAPLS------QQRWVGGS-VELHCEAVGSPVPEIQWWFEGQG 62
++ + G S AA VQ P Q + GGS V + C A G P P+I W
Sbjct: 592 MVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTV---- 647
Query: 63 PNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLVEEDTGTYECRASNDP--DRNHLT 120
ND + V H Y + T+ I +D G Y C ASN D+ + T
Sbjct: 648 -ND----------MFIVGSHR-YRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNST 695
Query: 121 ----RAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGV 176
AP++ V+++ +V LG ++ C S +W KG +
Sbjct: 696 LRYIEAPKLMVVQSELLVA-------------LGDITVMECKT--SGIPPPQVKWFKGDL 740
Query: 177 VLKE------DALPGQKTEFKVDSDDQWGEYSCVFLPEP---MGTANIQLHGPPRVKAVK 227
L+ D L G + + D G+Y+CV + E G + + PP
Sbjct: 741 ELRPSTFLIIDPLLGL-LKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEP 799
Query: 228 SSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSS-SQGRS-EL 285
+ + G L C + P T W ++ + M F VSS SQ R+ L
Sbjct: 800 ADVSMEIGSNVTLPCYVQGYPEPTI-KWRRLDN------MPIFSRPFSVSSISQLRTGAL 852
Query: 286 HIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSHLAALWPFLGIVAEV 335
I NL +D G Y C + G Q+ T+ V +A P +GI V
Sbjct: 853 FILNL-WASDKGTYICEAENQFGKIQSETTVTVTGLVA---PLIGISPSV 898
Score = 47.8 bits (112), Expect = 2e-05
Identities = 70/304 (23%), Positives = 114/304 (37%), Gaps = 54/304 (17%)
Query: 32 QQRWVGGSVELHCEAVGSPVPEIQWWFEGQ---GPNDTCSQLWDGARLDRVHIHATYHQH 88
Q+R +E C A G+P P I+W G+ G S L DG
Sbjct: 1276 QERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDG--------------- 1320
Query: 89 AASTISIDTLVEEDTGTYECRASNDPD--------RNHLTRAPRVKWVRAQAVVLVLEPG 140
+ + I ++ D G Y C A N+ + H+ + K VL+ +
Sbjct: 1321 --TLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLT 1378
Query: 141 TVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGE 200
+F VE S I++ N TE + + + G +LK F+ +D G
Sbjct: 1379 NLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILK---------LFRATPEDA-GR 1428
Query: 201 YSCVFLPEPMGTA----NIQLHGPPRVKAVKSSEHINE--GETAMLVCKSESVPPVTDWA 254
YSC + GT+ NI + PP + ++ L C+ + P D
Sbjct: 1429 YSCKAI-NIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGT-PFPDIH 1486
Query: 255 WYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAII 314
W+K + K L G + + Q LH++N D G+Y+C +++ G I
Sbjct: 1487 WFK----DGKPLFLGDPNVELLDRGQ---VLHLKNARRN-DKGRYQCTVSNAAGKQAKDI 1538
Query: 315 TLRV 318
L +
Sbjct: 1539 KLTI 1542
Score = 43.5 bits (101), Expect = 3e-04
Identities = 66/288 (22%), Positives = 103/288 (35%), Gaps = 44/288 (15%)
Query: 42 LHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLVEE 101
L CEA G P P I W G N +Q +Y ++ ++ I + +
Sbjct: 3823 LACEATGIPKPSINWRKNGHLLNVDQNQ-------------NSYRLLSSGSLVIISPSVD 3869
Query: 102 DTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCSLND 161
DT TYEC +N + R + Q + + T F + + ++TC+
Sbjct: 3870 DTATYECTVTNGAGDD-----KRTVDLTVQVPPSIADEPTDFLVTKH--APAVITCTA-- 3920
Query: 162 SATEVTGHRWLKGGVVLKEDA-----LPGQKTEFKVDSDDQWGEYSCVFLPEPMGTAN-- 214
S W K G+ L L E + G Y+CV G+A+
Sbjct: 3921 SGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCV-ARNAAGSAHRH 3979
Query: 215 --IQLHGPPRVKAVKSSEHINEGETAMLVCKSESVP-PVTDWAWYKITDSEDKALMNGSE 271
+ +H PP ++ S H+ +L C++ P P W ++ +N S
Sbjct: 3980 VTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITW-------QKEGINVNTSG 4032
Query: 272 SRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVR 319
V S G L I E D G Y C + G+ I L V+
Sbjct: 4033 RNHAVLPSGG---LQISRAVRE-DAGTYMCVAQNPAGTALGKIKLNVQ 4076
Score = 43.1 bits (100), Expect = 4e-04
Identities = 74/312 (23%), Positives = 117/312 (37%), Gaps = 50/312 (16%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
V ++ L CEA P + W+ +GQ D V+I A H T+ I
Sbjct: 2688 VNNTLTLECEAYAIPSASLSWYKDGQPLKSD----------DHVNIAANGH-----TLQI 2732
Query: 96 DTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVED------- 148
DTG Y C ASN + L ++ + + E G + T +
Sbjct: 2733 KEAQISDTGRYTCVASNIAGEDELDFDVNIQ--VPPSFQKLWEIGNMLDTGRNGEAKDVI 2790
Query: 149 LGSKILLTCSLNDSATEVTGHRWLKGGVVL----KEDALPGQKT-EFKVDSDDQWGEYSC 203
+ + I L C N A W K G L K LPG + + + G Y+C
Sbjct: 2791 INNPISLYCETN--AAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTC 2848
Query: 204 VFLPEPMGTA---NIQLHGPPRVKAVKSS--EHIN--EGETAMLVCKSESVP-PVTDWAW 255
V + E + ++++ PP +K S E + ++A++ C S P P W
Sbjct: 2849 VAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSW-- 2906
Query: 256 YKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIIT 315
+ + L+ +F S GR L I N + D G+Y C ++ GS +
Sbjct: 2907 ----QKDGQPLLEDDHHKFL---SNGRI-LQILNTQI-TDIGRYVCVAENTAGSAKKYFN 2957
Query: 316 LRVRSHLAALWP 327
L V + + P
Sbjct: 2958 LNVHVPPSVIGP 2969
Score = 42.4 bits (98), Expect = 7e-04
Identities = 33/122 (27%), Positives = 51/122 (41%), Gaps = 23/122 (18%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
+GG+ L+CE G P P IQW +G + I Q +++I
Sbjct: 4363 LGGNAILNCEVKGDPTPTIQWNRKGVD----------------IEISHRIRQLGNGSLAI 4406
Query: 96 DTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILL 155
V ED G Y C A+N+ + + ++ ++ LEP TV + G KI+L
Sbjct: 4407 YGTVNEDAGDYTCVATNEAGVVERSMSLTLQ----SPPIITLEP---VETVINAGGKIIL 4459
Query: 156 TC 157
C
Sbjct: 4460 NC 4461
Score = 41.6 bits (96), Expect = 0.001
Identities = 73/317 (23%), Positives = 116/317 (36%), Gaps = 63/317 (19%)
Query: 14 LGTHGASGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDG 73
L H G ++P + SV L CEA G P+P I W+ +G W
Sbjct: 2378 LSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDG----------WPV 2427
Query: 74 ARLDRVHIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAV 133
+ + V I + + + ED G Y C N + +
Sbjct: 2428 SLSNSVRILS-----GGRMLRLMQTTMEDAGQYTCVVRNAAGEER----------KIFGL 2472
Query: 134 VLVLEPGTV-FTTVEDLGSK----ILLTCSL-NDSATEVTGHRWLKGGVVLKEDAL---- 183
+++ P V T+ED+ K + LTC + + E+T W K G L+ED
Sbjct: 2473 SVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEIT---WHKDGQPLQEDEAHHII 2529
Query: 184 -PGQKTEFKVDSDDQWGEYSCVFLPEPMG----TANIQLHGPPRVKAVKSSEHINE---- 234
G+ + G Y+C+ P G + ++ + P + V S + +
Sbjct: 2530 SGGRFLQITNVQVPHTGRYTCL-ASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVI 2588
Query: 235 -GETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGS--ESRFFVSSSQGRSELHIENLN 291
LVC++ S PP T W+K +G+ ES + G L I N
Sbjct: 2589 LNSPTSLVCEAYSYPPAT-ITWFK----------DGTPLESNRNIRILPGGRTLQILNA- 2636
Query: 292 MEADPGQYRCNGTSSKG 308
E + G+Y C T+ G
Sbjct: 2637 QEDNAGRYSCVATNEAG 2653
Score = 40.8 bits (94), Expect = 0.002
Identities = 61/296 (20%), Positives = 110/296 (37%), Gaps = 44/296 (14%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G V L C+A G+P P + W +G+ + + ++ GA ++ +
Sbjct: 995 GIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGAD---------------GSLYVV 1039
Query: 97 TLVEEDTGTYECRASNDPD----RNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSK 152
+ E++G Y C A+N + LT R + Q + +P + G +
Sbjct: 1040 SPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLA---GEE 1096
Query: 153 ILLTCSLNDSATEVTGHRWLKGGVVL-----KEDALPGQKTEFKVDSDDQWGEYSCV--- 204
+ L C + + W K ++ + LP + G Y CV
Sbjct: 1097 VTLPCEVKSLPPPII--TWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATN 1154
Query: 205 FLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVP-PVTDWAWYKITDSED 263
+ +H PP+++ + G+ + C ++ P PV W+
Sbjct: 1155 IAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWS-----KGGS 1209
Query: 264 KALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVR 319
L++G VS+ G L I+ +D G Y C T+ G+D+ ITL V+
Sbjct: 1210 TMLVDGEHH---VSNPDGT--LSIDQAT-PSDAGIYTCVATNIAGTDETEITLHVQ 1259
Score = 40.0 bits (92), Expect = 0.004
Identities = 70/301 (23%), Positives = 117/301 (38%), Gaps = 55/301 (18%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
+G +VEL C A G P P IQW +G+ +R+ + A ST++I
Sbjct: 3260 LGENVELVCNANGIPTPLIQWLKDGKP--------IASGETERIRVSAN-----GSTLNI 3306
Query: 96 DTLVEEDTGTYECRASN---DPDR---NHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDL 149
+ DTG Y C A+N + DR ++ P ++ + +A L+ T V+
Sbjct: 3307 YGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLM-------TLVD-- 3357
Query: 150 GSKILLTCSLNDSATEVTGHRWLKGGVVLKEDA-----LPGQKTEFKVDSDDQWGEYSCV 204
+ I + C + T WLK G+ L + GQ Y+CV
Sbjct: 3358 -TSINIEC--RATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCV 3414
Query: 205 FLPEPMGT----ANIQLHGPPRVKAVKSSEHIN--EGETAMLVCKSESVPPVTDWAWYKI 258
G N+Q+ PP + +E I +G + + C ++ P AW +
Sbjct: 3415 -ASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGT-PAPSMAW--L 3470
Query: 259 TDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEA-DPGQYRCNGTSSKGSDQAIITLR 317
D + G ++ VS+ + ++ L E D G+Y C ++ G L+
Sbjct: 3471 RDGQPL----GLDAHLTVST----HGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILK 3522
Query: 318 V 318
V
Sbjct: 3523 V 3523
Score = 39.3 bits (90), Expect = 0.006
Identities = 72/294 (24%), Positives = 110/294 (37%), Gaps = 42/294 (14%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G + L CE+ G P P + W +G P T S + RV I + Q + I
Sbjct: 2211 GNLISLLCESSGIPPPNLIWKKKG-SPVLTDS-------MGRVRILSGGRQ-----LQIS 2257
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLT 156
+ D Y C ASN +V ++R P + T G I L
Sbjct: 2258 IAEKSDAALYSCVASNVAGTAKKEYNLQV-YIRPTITNSGSHPTEIIVT---RGKSISLE 2313
Query: 157 CSLNDSATEVT-----GHRWLKG-GVVLKEDALPGQKTEFKVDSDDQWGEYSCVFLPEPM 210
C + GH +K GV + ++ G + K G Y CV +
Sbjct: 2314 CEVQGIPPPTVTWMKDGHPLIKAKGVEILDE---GHILQLKNIHVSDTGRYVCVAVNVAG 2370
Query: 211 GT---ANIQLHGPPRVKA-VKSSEHIN--EGETAMLVCKSESVPPVTDWAWYKITDSEDK 264
T ++ +H PP + +S E+I+ E + L C++ + P+ W+K D
Sbjct: 2371 MTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGI-PLPSITWFK--DGWPV 2427
Query: 265 ALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRV 318
+L N V G L + ME D GQY C ++ G ++ I L V
Sbjct: 2428 SLSNS------VRILSGGRMLRLMQTTME-DAGQYTCVVRNAAGEERKIFGLSV 2474
Score = 38.5 bits (88), Expect = 0.010
Identities = 63/296 (21%), Positives = 96/296 (32%), Gaps = 56/296 (18%)
Query: 40 VELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLV 99
V L C A G P P I W + Q N L Q + + I +
Sbjct: 1844 VALQCIANGIPNPSITWLKDDQPVNTAQGNL--------------KIQSSGRVLQIAKTL 1889
Query: 100 EEDTGTYECRASNDPDRN------HLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKI 153
ED G Y C A+N H+ P ++ + G + + + +
Sbjct: 1890 LEDAGRYTCVATNAAGETQQHIQLHVHEPPSLE-----------DAGKMLNETVLVSNPV 1938
Query: 154 LLTCSLNDSATEVTGHRWLKGGVVLKEDALP-----GQKTEFKVDSDDQWGEYSCVFLPE 208
L C + V W K +L GQ + + G Y CV +
Sbjct: 1939 QLECKAAGNPVPVI--TWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINS 1996
Query: 209 PMGTA---NIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVP-PVTDWAWYKITDSEDK 264
T ++Q+H P + + + L C++ +P P W
Sbjct: 1997 AGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTW----------- 2045
Query: 265 ALMNGSESRFFVSSSQGRSELHIENLNME--ADPGQYRCNGTSSKGSDQAIITLRV 318
L +GS F + Q S I L +D G+Y C ++ G Q I LRV
Sbjct: 2046 -LKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRV 2100
Score = 38.5 bits (88), Expect = 0.010
Identities = 70/302 (23%), Positives = 108/302 (35%), Gaps = 61/302 (20%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G S+ L CE G P P + W +G + LD HI + +
Sbjct: 2307 GKSISLECEVQGIPPPTVTWMKDGH----PLIKAKGVEILDEGHI-----------LQLK 2351
Query: 97 TLVEEDTGTYECRASN-----DPDRNHLTRAPR--VKWVRAQAVVLVLEPGTVFTTVEDL 149
+ DTG Y C A N D + AP + R+ + V+E +V T E
Sbjct: 2352 NIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEAS 2411
Query: 150 G--------SKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEY 201
G K SL++S ++G R L+ EDA G+Y
Sbjct: 2412 GIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDA----------------GQY 2455
Query: 202 SCVF---LPEPMGTANIQLHGPPRVKAVKSSE--HINEGETAMLVCKSESVPPVTDWAWY 256
+CV E + + PP + + E + E ++ L C+ PV + W+
Sbjct: 2456 TCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTG-NPVPEITWH 2514
Query: 257 KITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITL 316
K D + E+ +S G L I N+ + G+Y C +S G +L
Sbjct: 2515 K-----DGQPLQEDEAHHIIS---GGRFLQITNVQV-PHTGRYTCLASSPAGHKSRSFSL 2565
Query: 317 RV 318
V
Sbjct: 2566 NV 2567
Score = 36.6 bits (83), Expect = 0.039
Identities = 62/291 (21%), Positives = 104/291 (35%), Gaps = 57/291 (19%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
+ ++L CE G P+P I W+ +GQ P + SQ ++I + H I
Sbjct: 1561 INSLIKLECETRGLPMPAITWYKDGQ-PIMSSSQ--------ALYIDKGQYLH------I 1605
Query: 96 DTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVED---LGSK 152
D+ TY C +N K V + G + T + +
Sbjct: 1606 PRAQVSDSATYTCHVAN-------VAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHS 1658
Query: 153 ILLTCSLNDSATEVTGHRWLKGGVVLKED-----ALPGQKTEFKVDSDDQWGEYSCV--- 204
+ L C + + + WLK GV +K + G+K E + G+Y CV
Sbjct: 1659 LTLECKAAGNPSPIL--TWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATS 1716
Query: 205 FLPEPMGTANIQLHGPPRVKAVKSSEH--INEGETAMLVCKSESVPPVTDWAWYK---IT 259
E + + PP ++ + + + L C PP T W K +
Sbjct: 1717 VAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPT-IMWLKDGQLI 1775
Query: 260 DSED--KALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKG 308
D D K L+NG + ++ +Q ++ G YRC ++ G
Sbjct: 1776 DERDGFKILLNG--RKLVIAQAQ------------VSNTGLYRCMAANTAG 1812
Score = 36.2 bits (82), Expect = 0.051
Identities = 63/300 (21%), Positives = 105/300 (35%), Gaps = 51/300 (17%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPN-DTCSQLWDGARLDRVHIHATYHQHAASTIS 94
V + L CE G P P++ W Q +T + + G R T+
Sbjct: 2978 VNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGR----------------TLQ 3021
Query: 95 IDTLVEEDTGTYECRASNDPDRNH------LTRAPRVKWVRAQAVVLVLEPGTVFTTVED 148
I D G Y C A N + + P +K ++++ +V V +
Sbjct: 3022 IIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVV--------NVRE 3073
Query: 149 LGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDA-----LPGQKTEFKVDSDDQWGEYSC 203
G+ + L C N V W K G ++ E GQ K G+Y C
Sbjct: 3074 -GTSVSLECESNAVPPPVI--TWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVC 3130
Query: 204 VFL---PEPMGTANIQLHGPPRVKAVKSSEHINE-GETAMLVCKSESVPPVTDWAWYKIT 259
+ ++ ++ PP ++ + + L C + +PP T AW K
Sbjct: 3131 RAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPT-IAWLK-- 3187
Query: 260 DSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVR 319
K + N + S G S+L I + +D G Y C ++ +G Q L ++
Sbjct: 3188 --NHKRIENSDSLEVRILS--GGSKLQIAR-SQHSDSGNYTCIASNMEGKAQKYYFLSIQ 3242
Score = 32.3 bits (72), Expect = 0.74
Identities = 50/237 (21%), Positives = 81/237 (34%), Gaps = 53/237 (22%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
+ V L C+A G P P I W L + R++ S + I
Sbjct: 3165 ISNPVTLTCDATGIPPPTIAW-------------LKNHKRIENSDSLEVRILSGGSKLQI 3211
Query: 96 DTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILL 155
D+G Y C ASN +A + ++ Q V LG + L
Sbjct: 3212 ARSQHSDSGNYTCIASNMEG-----KAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVEL 3266
Query: 156 TCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSD-----------DQWGEYSCV 204
C+ N T + +WLK G + G+ +V ++ G+Y+CV
Sbjct: 3267 VCNANGIPTPLI--QWLKDG----KPIASGETERIRVSANGSTLNIYGALTSDTGKYTCV 3320
Query: 205 FLPEPMGTA----NIQLHGPPRVKAVKSSEHINEGETAM--------LVCKSESVPP 249
P G N+ ++ P ++ K +E E M + C++ PP
Sbjct: 3321 -ATNPAGEEDRIFNLNVYVTPTIRGNK-----DEAEKLMTLVDTSINIECRATGTPP 3371
Score = 31.2 bits (69), Expect = 1.6
Identities = 45/187 (24%), Positives = 76/187 (40%), Gaps = 25/187 (13%)
Query: 137 LEPGTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDD 196
L+PG + +V+ L + T S + + ++LK + D KV D
Sbjct: 444 LQPGQIPCSVDSL---LPFTLSFVRNGVTLGVDQYLKESASVNLDIA-------KVTLSD 493
Query: 197 QWGEYSCVFLPEPMGTANIQ----LHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTD 252
+ G Y C+ + GT Q + PP V V ++ + GE A+L C S +
Sbjct: 494 E-GFYECIAVSSA-GTGRAQTFFDVSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDY-N 550
Query: 253 WAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQA 312
W + + D L + R + S L ++++ D G+Y C +S GS A
Sbjct: 551 LTWQR--NDRDVRLAEPARIRTLANLS-----LELKSVKFN-DAGEYHCMVSSEGGSSAA 602
Query: 313 IITLRVR 319
+ L V+
Sbjct: 603 SVFLTVQ 609
>gi|58331253 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform a [Homo sapiens]
Length = 6620
Score = 60.5 bits (145), Expect = 3e-09
Identities = 76/300 (25%), Positives = 123/300 (41%), Gaps = 57/300 (19%)
Query: 33 QRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAAST 92
Q G S L CE V E+ W+ +G+ + + +VH+ A +
Sbjct: 993 QAEAGASATLSCE-VAQAQTEVMWYKDGKKLSSSL----------KVHVEA---KGCRRR 1038
Query: 93 ISIDTLVEEDTGTYECRASND--PDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLG 150
+ + + D G Y C A R H+T P++ + + Q+V ++ + G
Sbjct: 1039 LVVQQAGKTDAGDYSCEARGQRVSFRLHITE-PKMMFAKEQSVHNEVQA--------EAG 1089
Query: 151 SKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTE-----------FKVDSDDQWG 199
+ +L+C + + TEVT W K G L + G + + K D+ G
Sbjct: 1090 ASAMLSCEVAQAQTEVT---WYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADA----G 1142
Query: 200 EYSCVFLPEPMGTANIQLHGPPRVKAVKSSEH----INEGETAMLVCKSESVPPVTDWAW 255
EYSC + + + ++ + P V A + S H G TAML C E P T+ W
Sbjct: 1143 EYSCEAGGQRV-SFHLHITEPKGVFAKEQSVHNEVQAEAGTTAMLSC--EVAQPQTEVTW 1199
Query: 256 YKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIIT 315
YK + K L + S+ R V R L ++ + +AD G+Y C + S Q IT
Sbjct: 1200 YK----DGKKLSSSSKVRMEVKGCTRR--LVVQQVG-KADAGEYSCEAGGQRVSFQLHIT 1252
Score = 52.8 bits (125), Expect = 5e-07
Identities = 80/303 (26%), Positives = 120/303 (39%), Gaps = 50/303 (16%)
Query: 25 FVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHAT 84
F + +++ G + L CE S + ++WW +G L DG R H+
Sbjct: 3628 FTEGLRNEEATEGATAVLRCEL--SKMAPVEWW-KGH------ETLRDGDR------HSL 3672
Query: 85 YHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLT-RAPRVKWVRAQAVVLVLEPGTVF 143
A + I LV ED G Y C + LT RA K++ L E T
Sbjct: 3673 RQDGARCELQIRGLVAEDAGEYLCMCGKERTSAMLTVRAMPSKFIEG----LRNEEATE- 3727
Query: 144 TTVEDLGSKILLTCSLNDSATEV--TGHRWLKGG--VVLKEDALPGQKTEFKVD--SDDQ 197
G L C L+ +A GH L+ G L++D G + E ++ +
Sbjct: 3728 ------GDTATLWCELSKAAPVEWRKGHETLRDGDRHSLRQD---GSRCELQIRGLAVVD 3778
Query: 198 WGEYSCVFLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYK 257
GEYSCV E P R ++ EG TA+L C+ PV W K
Sbjct: 3779 AGEYSCVCGQERTSATLTVRALPARFIEDVKNQEAREGATAVLQCELSKAAPV---EWRK 3835
Query: 258 ITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLR 317
+++ + G + R+ + R EL I L++ AD G+Y C G ++ TL
Sbjct: 3836 GSET-----LRGGD-RYSLRQDGTRCELQIHGLSV-ADTGEYSC----VCGQERTSATLT 3884
Query: 318 VRS 320
VR+
Sbjct: 3885 VRA 3887
Score = 45.4 bits (106), Expect = 8e-05
Identities = 72/295 (24%), Positives = 107/295 (36%), Gaps = 54/295 (18%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
GG + CE + V + W+ +G + G R + + T H+ A+T++
Sbjct: 812 GGPAQFECETSEAHV-HVHWYKDGMELGHS------GERFLQEDV-GTRHRLVAATVT-- 861
Query: 97 TLVEEDTGTYECRASNDP-DRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILL 155
+D GTY CR D D P+V + + Q L+ + G+ L
Sbjct: 862 ---RQDEGTYSCRVGEDSVDFRLRVSEPKVVFAKEQLARRKLQ--------AEAGASATL 910
Query: 156 TCSLNDSATEVTGHRWLKGGVVLKEDA-----LPGQKTEFKVDSDDQ--WGEYSCVFLPE 208
+C + + TEVT W K G L + G V Q GEYSC
Sbjct: 911 SCEVAQAQTEVT---WYKDGKKLSSSSKVCMEATGCTRRLVVQQAGQADAGEYSC----- 962
Query: 209 PMGTANIQLH---GPPRVKAVK-----SSEHINEGETAMLVCKSESVPPVTDWAWYKITD 260
G + H P+V K S G +A L C E T+ WYK
Sbjct: 963 EAGGQRLSFHLDVKEPKVVFAKDQVAHSEVQAEAGASATLSC--EVAQAQTEVMWYK--- 1017
Query: 261 SEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIIT 315
+ K L S + V + R L ++ + D G Y C + S + IT
Sbjct: 1018 -DGKKL--SSSLKVHVEAKGCRRRLVVQQAG-KTDAGDYSCEARGQRVSFRLHIT 1068
Score = 40.8 bits (94), Expect = 0.002
Identities = 77/306 (25%), Positives = 120/306 (39%), Gaps = 56/306 (18%)
Query: 23 AGFVQAPLSQQRWVGGSVELHCE-AVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHI 81
A F+ Q+ G + L CE + +PV W +G+ L DG R
Sbjct: 3362 AHFIGRLRHQESIEGATATLRCELSKAAPVE----WRKGR------ESLRDGDR------ 3405
Query: 82 HATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLT-RAPRVKWVRAQAVVLVLEPG 140
H+ A + I L D G Y C + LT +A K+ +E
Sbjct: 3406 HSLRQDGAVCELQICGLAVADAGEYSCVCGEERTSATLTVKALPAKFTEGLRNEEAVE-- 3463
Query: 141 TVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKED-----ALPGQKTEFKVD-- 193
G+ +L C L+ +V W KG L++ G + E ++
Sbjct: 3464 ---------GATAMLWCELS----KVAPVEWRKGPENLRDGDRYILRQEGTRCELQICGL 3510
Query: 194 SDDQWGEYSCVFLPEPMGTANIQLHGPPR--VKAVKSSEHINEGETAMLVCKSESVPPVT 251
+ GEY CV E +A + + P ++ VK+ E EG TA+L C+ S PV
Sbjct: 3511 AMADAGEYLCVCGQERT-SATLTIRALPARFIEDVKNQE-AREGATAVLQCELNSAAPV- 3567
Query: 252 DWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQ 311
W K +++ L +G R+ + + EL I L M AD G+Y C +
Sbjct: 3568 --EWRKGSET----LRDG--DRYSLRQDGTKCELQIRGLAM-ADTGEYSC--VCGQERTS 3616
Query: 312 AIITLR 317
A++T+R
Sbjct: 3617 AMLTVR 3622
Score = 38.5 bits (88), Expect = 0.010
Identities = 52/188 (27%), Positives = 75/188 (39%), Gaps = 27/188 (14%)
Query: 148 DLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDAL------PGQKTEFKVDS--DDQWG 199
+LG + L C + + V W K G ++ D P +DS G
Sbjct: 6026 ELGETVKLACRVTGTPKPVIS--WYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSG 6083
Query: 200 EYSCVFLPEPMGTAN----IQLHGPPR-VKAVKSSEHINEGETAMLVCKSESVPPVTDWA 254
+Y C F G + I + PPR V V++S + EGE A C E P
Sbjct: 6084 QYMC-FAASAAGNCSTLGKILVQVPPRFVNKVRASPFV-EGEDAQFTCTIEGAP-YPQIR 6140
Query: 255 WYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEA--DPGQYRCNGTSSKGSDQA 312
WYK D AL+ F + S+ RS L + + + D G Y C + GS +A
Sbjct: 6141 WYK-----DGALLTTGNK--FQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARA 6193
Query: 313 IITLRVRS 320
LR++S
Sbjct: 6194 SAELRIQS 6201
Score = 36.6 bits (83), Expect = 0.039
Identities = 68/263 (25%), Positives = 99/263 (37%), Gaps = 36/263 (13%)
Query: 66 TCSQLWDGARLDRVHIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRV 125
T + L DG + R H T Q T+++ D+ Y CR + + +V
Sbjct: 1749 TVTWLKDGVEIRRSKRHETASQGDTHTLTVHGAQVLDSAIYSCRVGAEGQDFPV----QV 1804
Query: 126 KWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPG 185
+ V A+ L LEP +LG + L C L+ + EV W G L+
Sbjct: 1805 EEVAAKFCRL-LEP-----VCGELGGTVTLACELSPACAEVV---WRCGNTQLRVGKRFQ 1855
Query: 186 QKTEFKVDS-------DDQWGEYSCVFLPEPMGTANIQLHGPPRVKAVK--SSEHINEGE 236
E V S + GEY C + +A + + P VK + S+ EG
Sbjct: 1856 MVAEGPVRSLTVLGLRAEDAGEYVCESRDDHT-SAQLTVSVPRVVKFMSGLSTVVAEEGG 1914
Query: 237 TAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADP 296
A C P W++ D AL+ SE +F +S S L I +L +E D
Sbjct: 1915 EATFQCVVS--PSDVAVVWFR-----DGALLQPSE-KFAISQSGASHSLTISDLVLE-DA 1965
Query: 297 GQYRCNGTSSKGSDQAIITLRVR 319
GQ + S LRVR
Sbjct: 1966 GQITVEAEGASSS----AALRVR 1984
Score = 36.2 bits (82), Expect = 0.051
Identities = 28/93 (30%), Positives = 39/93 (41%), Gaps = 13/93 (13%)
Query: 20 SGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRV 79
SGA F+ P + VG L C+ VG+P P++ W + Q + GAR
Sbjct: 7 SGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQ-------PVAAGARFRLA 59
Query: 80 HIHATYHQHAASTISIDTLVEEDTGTYECRASN 112
Y ++I L D+G Y CRA N
Sbjct: 60 QDGDLYR------LTILDLALGDSGQYVCRARN 86
Score = 33.9 bits (76), Expect = 0.25
Identities = 84/355 (23%), Positives = 126/355 (35%), Gaps = 79/355 (22%)
Query: 19 ASGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDR 78
A A F+ P S + G C GSP P + W +G+ + DG R+ R
Sbjct: 106 AEQAPHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEP-----DGPRV-R 159
Query: 79 VHIHATYHQHAASTISIDTLVEEDTGTYECRASN-------------DPDRNHLTRAP-- 123
V AS + I D GTYE RA N D D P
Sbjct: 160 VE-----ELGEASALRIRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGT 214
Query: 124 -----------RVKWVRAQ-AVVLVLEPGTVFTTVEDLGSKILLTCSLNDSATEVTGHRW 171
R + +RA+ A GT TV + G L+C + T W
Sbjct: 215 STAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTE-GKHARLSCYVTGEPKPET--VW 271
Query: 172 LKGGV--------VLKEDALPGQKTEFKVDSDDQWGEYSCV---FLPEPMGTANIQLHGP 220
K G V+ EDA + G Y+C + + + + + P
Sbjct: 272 KKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVREP 331
Query: 221 --PRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSS 278
P K ++ E + E E+A +C E P T+ AW+K E+R + S+
Sbjct: 332 AVPFKKRLQDLE-VREKESATFLC--EVPQPSTEAAWFK------------EETRLWASA 376
Query: 279 SQGRSE------LHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSHLAALWP 327
G E L + N++ + D Y C + +GS + + L V+ +L P
Sbjct: 377 KYGIEEEGTERRLTVRNVSAD-DDAVYICE--TPEGS-RTVAELAVQGNLLRKLP 427
Score = 33.9 bits (76), Expect = 0.25
Identities = 61/273 (22%), Positives = 96/273 (35%), Gaps = 46/273 (16%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAAS-TISI 95
G L C G P PE W +GQ + +G R H Y + + I
Sbjct: 252 GKHARLSCYVTGEPKPETVWKKDGQ-------LVTEGRR------HVVYEDAQENFVLKI 298
Query: 96 DTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVF-TTVEDL----G 150
+ D G Y C ASN V + +V+V EP F ++DL
Sbjct: 299 LFCKQSDRGLYTCTASN-----------LVGQTYSSVLVVVREPAVPFKKRLQDLEVREK 347
Query: 151 SKILLTCSLNDSATEVTGHR-----WLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVF 205
C + +TE + W ++E+ + T V +DD Y C
Sbjct: 348 ESATFLCEVPQPSTEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDD-AVYICET 406
Query: 206 LPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKA 265
A + + G ++ + + G+TAM E PV W + ++++
Sbjct: 407 PEGSRTVAELAVQG-NLLRKLPRKTAVRVGDTAMFCV--ELAVPVGPVHWLR---NQEEV 460
Query: 266 LMNGSESRFFVSSSQGRSELHIENLNMEADPGQ 298
+ G R +S+ R L I +E D GQ
Sbjct: 461 VAGG---RVAISAEGTRHTLTISQCCLE-DVGQ 489
Score = 33.9 bits (76), Expect = 0.25
Identities = 58/242 (23%), Positives = 87/242 (35%), Gaps = 37/242 (15%)
Query: 87 QHAASTISIDTLVEEDTGTYECRASNDPDRNHLT-RAPRVKWVRAQAVVLVLEPGTVFTT 145
Q + + + L EDTG Y C + LT A V+++R V E GT
Sbjct: 3940 QGCTAELVLQDLQREDTGEYTCTCGSQATSATLTVTAAPVRFLRELQHQEVDEGGTAH-- 3997
Query: 146 VEDLGSKILLTCSLNDSATEVTGHRWLKGGVVL--------KEDALPGQKTEFKVDSDDQ 197
L C L+ + V W KG + L +D + V+ +D
Sbjct: 3998 ---------LCCELSRAGASV---EWRKGSLQLFPCAKYQMVQDGAAAELLVRGVEQEDA 4045
Query: 198 WGEYSCVFLPEPMGTANIQLHGP-PRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWY 256
G+Y+C A++ + P P+ K S G+ A L C+ W
Sbjct: 4046 -GDYTC-DTGHTQSMASLSVRVPRPKFKTRLQSLEQETGDIARLCCQLSDAESGAVVQWL 4103
Query: 257 KITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITL 316
K E L G ++ + S EL I L + D G+Y C G + +L
Sbjct: 4104 K----EGVELHAG--PKYEMRSQGATRELLIHQLEAK-DTGEYAC----VTGGQKTAASL 4152
Query: 317 RV 318
RV
Sbjct: 4153 RV 4154
Score = 33.1 bits (74), Expect = 0.43
Identities = 20/77 (25%), Positives = 36/77 (46%), Gaps = 12/77 (15%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
+G +V+L C G+P P I W+ +G+ ++D HI + + +
Sbjct: 6027 LGETVKLACRVTGTPKPVISWYKDGK-----------AVQVDPHHI-LIEDPDGSCALIL 6074
Query: 96 DTLVEEDTGTYECRASN 112
D+L D+G Y C A++
Sbjct: 6075 DSLTGVDSGQYMCFAAS 6091
Score = 31.2 bits (69), Expect = 1.6
Identities = 21/94 (22%), Positives = 34/94 (36%), Gaps = 12/94 (12%)
Query: 19 ASGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDR 78
+ A F+ +Q+ G V C G P+P ++W+ +G+ +
Sbjct: 5122 SDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGK------------LLEED 5169
Query: 79 VHIHATYHQHAASTISIDTLVEEDTGTYECRASN 112
H Q + I +V D G Y C A N
Sbjct: 5170 DHYMINEDQQGGHQLIITAVVPADMGVYRCLAEN 5203
Score = 30.8 bits (68), Expect = 2.1
Identities = 26/84 (30%), Positives = 37/84 (44%), Gaps = 9/84 (10%)
Query: 234 EGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNME 293
E ++ +L C P W YK D ++ SE +F +S +EL I L M
Sbjct: 2482 ELQSVVLSCDFRPAPKAVQW--YK-----DDTPLSPSE-KFKMSLEGQMAELRILRL-MP 2532
Query: 294 ADPGQYRCNGTSSKGSDQAIITLR 317
AD G YRC S+ S + + R
Sbjct: 2533 ADAGVYRCQAGSAHSSTEVTVEAR 2556
Score = 30.8 bits (68), Expect = 2.1
Identities = 20/76 (26%), Positives = 30/76 (39%), Gaps = 7/76 (9%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G S+ + G PVP + W E LW G + ++ QH+ + +
Sbjct: 5385 GSSITFSVKVEGRPVPTVHWLRE----EAERGVLWIGPDTPGYTVASSAQQHSLVLLDVG 5440
Query: 97 TLVEEDTGTYECRASN 112
+ GTY C ASN
Sbjct: 5441 ---RQHQGTYTCIASN 5453
Score = 29.6 bits (65), Expect = 4.8
Identities = 32/133 (24%), Positives = 53/133 (39%), Gaps = 10/133 (7%)
Query: 169 HRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTANIQLHGPPRVKAVKS 228
H + G + + PG+ F+V + G V LP+ + A PP+ A +S
Sbjct: 4573 HELVPGPECVVDGLAPGETYRFRVAAVGPVGAGEPVHLPQTVRLAEPPKPVPPQPSAPES 4632
Query: 229 SEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIE 288
+ + GE L + E V + W+K ++ G F SQGR ++ +
Sbjct: 4633 RQ-VAAGEDVSL--ELEVVAEAGEVIWHK---GMERIQPGGR----FEVVSQGRQQMLVI 4682
Query: 289 NLNMEADPGQYRC 301
D G+Y C
Sbjct: 4683 KGFTAEDQGEYHC 4695
>gi|148833506 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform b [Homo sapiens]
Length = 7968
Score = 60.5 bits (145), Expect = 3e-09
Identities = 76/300 (25%), Positives = 123/300 (41%), Gaps = 57/300 (19%)
Query: 33 QRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAAST 92
Q G S L CE V E+ W+ +G+ + + +VH+ A +
Sbjct: 993 QAEAGASATLSCE-VAQAQTEVMWYKDGKKLSSSL----------KVHVEA---KGCRRR 1038
Query: 93 ISIDTLVEEDTGTYECRASND--PDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLG 150
+ + + D G Y C A R H+T P++ + + Q+V ++ + G
Sbjct: 1039 LVVQQAGKTDAGDYSCEARGQRVSFRLHITE-PKMMFAKEQSVHNEVQA--------EAG 1089
Query: 151 SKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTE-----------FKVDSDDQWG 199
+ +L+C + + TEVT W K G L + G + + K D+ G
Sbjct: 1090 ASAMLSCEVAQAQTEVT---WYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADA----G 1142
Query: 200 EYSCVFLPEPMGTANIQLHGPPRVKAVKSSEH----INEGETAMLVCKSESVPPVTDWAW 255
EYSC + + + ++ + P V A + S H G TAML C E P T+ W
Sbjct: 1143 EYSCEAGGQRV-SFHLHITEPKGVFAKEQSVHNEVQAEAGTTAMLSC--EVAQPQTEVTW 1199
Query: 256 YKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIIT 315
YK + K L + S+ R V R L ++ + +AD G+Y C + S Q IT
Sbjct: 1200 YK----DGKKLSSSSKVRMEVKGCTRR--LVVQQVG-KADAGEYSCEAGGQRVSFQLHIT 1252
Score = 52.8 bits (125), Expect = 5e-07
Identities = 80/303 (26%), Positives = 120/303 (39%), Gaps = 50/303 (16%)
Query: 25 FVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHAT 84
F + +++ G + L CE S + ++WW +G L DG R H+
Sbjct: 3628 FTEGLRNEEATEGATAVLRCEL--SKMAPVEWW-KGH------ETLRDGDR------HSL 3672
Query: 85 YHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLT-RAPRVKWVRAQAVVLVLEPGTVF 143
A + I LV ED G Y C + LT RA K++ L E T
Sbjct: 3673 RQDGARCELQIRGLVAEDAGEYLCMCGKERTSAMLTVRAMPSKFIEG----LRNEEATE- 3727
Query: 144 TTVEDLGSKILLTCSLNDSATEV--TGHRWLKGG--VVLKEDALPGQKTEFKVD--SDDQ 197
G L C L+ +A GH L+ G L++D G + E ++ +
Sbjct: 3728 ------GDTATLWCELSKAAPVEWRKGHETLRDGDRHSLRQD---GSRCELQIRGLAVVD 3778
Query: 198 WGEYSCVFLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYK 257
GEYSCV E P R ++ EG TA+L C+ PV W K
Sbjct: 3779 AGEYSCVCGQERTSATLTVRALPARFIEDVKNQEAREGATAVLQCELSKAAPV---EWRK 3835
Query: 258 ITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLR 317
+++ + G + R+ + R EL I L++ AD G+Y C G ++ TL
Sbjct: 3836 GSET-----LRGGD-RYSLRQDGTRCELQIHGLSV-ADTGEYSC----VCGQERTSATLT 3884
Query: 318 VRS 320
VR+
Sbjct: 3885 VRA 3887
Score = 45.4 bits (106), Expect = 8e-05
Identities = 72/295 (24%), Positives = 107/295 (36%), Gaps = 54/295 (18%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
GG + CE + V + W+ +G + G R + + T H+ A+T++
Sbjct: 812 GGPAQFECETSEAHV-HVHWYKDGMELGHS------GERFLQEDV-GTRHRLVAATVT-- 861
Query: 97 TLVEEDTGTYECRASNDP-DRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILL 155
+D GTY CR D D P+V + + Q L+ + G+ L
Sbjct: 862 ---RQDEGTYSCRVGEDSVDFRLRVSEPKVVFAKEQLARRKLQ--------AEAGASATL 910
Query: 156 TCSLNDSATEVTGHRWLKGGVVLKEDA-----LPGQKTEFKVDSDDQ--WGEYSCVFLPE 208
+C + + TEVT W K G L + G V Q GEYSC
Sbjct: 911 SCEVAQAQTEVT---WYKDGKKLSSSSKVCMEATGCTRRLVVQQAGQADAGEYSC----- 962
Query: 209 PMGTANIQLH---GPPRVKAVK-----SSEHINEGETAMLVCKSESVPPVTDWAWYKITD 260
G + H P+V K S G +A L C E T+ WYK
Sbjct: 963 EAGGQRLSFHLDVKEPKVVFAKDQVAHSEVQAEAGASATLSC--EVAQAQTEVMWYK--- 1017
Query: 261 SEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIIT 315
+ K L S + V + R L ++ + D G Y C + S + IT
Sbjct: 1018 -DGKKL--SSSLKVHVEAKGCRRRLVVQQAG-KTDAGDYSCEARGQRVSFRLHIT 1068
Score = 40.8 bits (94), Expect = 0.002
Identities = 77/306 (25%), Positives = 120/306 (39%), Gaps = 56/306 (18%)
Query: 23 AGFVQAPLSQQRWVGGSVELHCE-AVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHI 81
A F+ Q+ G + L CE + +PV W +G+ L DG R
Sbjct: 3362 AHFIGRLRHQESIEGATATLRCELSKAAPVE----WRKGR------ESLRDGDR------ 3405
Query: 82 HATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLT-RAPRVKWVRAQAVVLVLEPG 140
H+ A + I L D G Y C + LT +A K+ +E
Sbjct: 3406 HSLRQDGAVCELQICGLAVADAGEYSCVCGEERTSATLTVKALPAKFTEGLRNEEAVE-- 3463
Query: 141 TVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKED-----ALPGQKTEFKVD-- 193
G+ +L C L+ +V W KG L++ G + E ++
Sbjct: 3464 ---------GATAMLWCELS----KVAPVEWRKGPENLRDGDRYILRQEGTRCELQICGL 3510
Query: 194 SDDQWGEYSCVFLPEPMGTANIQLHGPPR--VKAVKSSEHINEGETAMLVCKSESVPPVT 251
+ GEY CV E +A + + P ++ VK+ E EG TA+L C+ S PV
Sbjct: 3511 AMADAGEYLCVCGQERT-SATLTIRALPARFIEDVKNQE-AREGATAVLQCELNSAAPV- 3567
Query: 252 DWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQ 311
W K +++ L +G R+ + + EL I L M AD G+Y C +
Sbjct: 3568 --EWRKGSET----LRDG--DRYSLRQDGTKCELQIRGLAM-ADTGEYSC--VCGQERTS 3616
Query: 312 AIITLR 317
A++T+R
Sbjct: 3617 AMLTVR 3622
Score = 38.5 bits (88), Expect = 0.010
Identities = 52/188 (27%), Positives = 75/188 (39%), Gaps = 27/188 (14%)
Query: 148 DLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDAL------PGQKTEFKVDS--DDQWG 199
+LG + L C + + V W K G ++ D P +DS G
Sbjct: 6026 ELGETVKLACRVTGTPKPVIS--WYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSG 6083
Query: 200 EYSCVFLPEPMGTAN----IQLHGPPR-VKAVKSSEHINEGETAMLVCKSESVPPVTDWA 254
+Y C F G + I + PPR V V++S + EGE A C E P
Sbjct: 6084 QYMC-FAASAAGNCSTLGKILVQVPPRFVNKVRASPFV-EGEDAQFTCTIEGAP-YPQIR 6140
Query: 255 WYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEA--DPGQYRCNGTSSKGSDQA 312
WYK D AL+ F + S+ RS L + + + D G Y C + GS +A
Sbjct: 6141 WYK-----DGALLTTGNK--FQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARA 6193
Query: 313 IITLRVRS 320
LR++S
Sbjct: 6194 SAELRIQS 6201
Score = 37.0 bits (84), Expect = 0.030
Identities = 45/165 (27%), Positives = 63/165 (38%), Gaps = 31/165 (18%)
Query: 8 LLGFALLGTHGASGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTC 67
L F L G A F++ + +G SV L C+ P + W +G P ++
Sbjct: 7448 LASFRLSGLKSWDRAPTFLRELSDETVVLGQSVTLACQVSAQPAAQATWSKDG-APLESS 7506
Query: 68 SQLWDGARLDRVHIHATYHQHAASTISIDTLVEEDTGTYECRASN------------DPD 115
S RV I AT TI + +V ED G Y C SN +
Sbjct: 7507 S---------RVLISATLKNFQLLTILV--VVAEDLGVYTCSVSNALGTVTTTGVLRKAE 7555
Query: 116 RNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGS-KILLTCSL 159
R + P + V A V+LV +P VE G ++ CSL
Sbjct: 7556 RPSSSPCPDIGEVYADGVLLVWKP------VESYGPVTYIVQCSL 7594
Score = 36.6 bits (83), Expect = 0.039
Identities = 68/263 (25%), Positives = 99/263 (37%), Gaps = 36/263 (13%)
Query: 66 TCSQLWDGARLDRVHIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRV 125
T + L DG + R H T Q T+++ D+ Y CR + + +V
Sbjct: 1749 TVTWLKDGVEIRRSKRHETASQGDTHTLTVHGAQVLDSAIYSCRVGAEGQDFPV----QV 1804
Query: 126 KWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPG 185
+ V A+ L LEP +LG + L C L+ + EV W G L+
Sbjct: 1805 EEVAAKFCRL-LEP-----VCGELGGTVTLACELSPACAEVV---WRCGNTQLRVGKRFQ 1855
Query: 186 QKTEFKVDS-------DDQWGEYSCVFLPEPMGTANIQLHGPPRVKAVK--SSEHINEGE 236
E V S + GEY C + +A + + P VK + S+ EG
Sbjct: 1856 MVAEGPVRSLTVLGLRAEDAGEYVCESRDDHT-SAQLTVSVPRVVKFMSGLSTVVAEEGG 1914
Query: 237 TAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADP 296
A C P W++ D AL+ SE +F +S S L I +L +E D
Sbjct: 1915 EATFQCVVS--PSDVAVVWFR-----DGALLQPSE-KFAISQSGASHSLTISDLVLE-DA 1965
Query: 297 GQYRCNGTSSKGSDQAIITLRVR 319
GQ + S LRVR
Sbjct: 1966 GQITVEAEGASSS----AALRVR 1984
Score = 36.2 bits (82), Expect = 0.051
Identities = 28/93 (30%), Positives = 39/93 (41%), Gaps = 13/93 (13%)
Query: 20 SGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRV 79
SGA F+ P + VG L C+ VG+P P++ W + Q + GAR
Sbjct: 7 SGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQ-------PVAAGARFRLA 59
Query: 80 HIHATYHQHAASTISIDTLVEEDTGTYECRASN 112
Y ++I L D+G Y CRA N
Sbjct: 60 QDGDLYR------LTILDLALGDSGQYVCRARN 86
Score = 33.9 bits (76), Expect = 0.25
Identities = 84/355 (23%), Positives = 126/355 (35%), Gaps = 79/355 (22%)
Query: 19 ASGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDR 78
A A F+ P S + G C GSP P + W +G+ + DG R+ R
Sbjct: 106 AEQAPHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEP-----DGPRV-R 159
Query: 79 VHIHATYHQHAASTISIDTLVEEDTGTYECRASN-------------DPDRNHLTRAP-- 123
V AS + I D GTYE RA N D D P
Sbjct: 160 VE-----ELGEASALRIRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGT 214
Query: 124 -----------RVKWVRAQ-AVVLVLEPGTVFTTVEDLGSKILLTCSLNDSATEVTGHRW 171
R + +RA+ A GT TV + G L+C + T W
Sbjct: 215 STAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVTE-GKHARLSCYVTGEPKPET--VW 271
Query: 172 LKGGV--------VLKEDALPGQKTEFKVDSDDQWGEYSCV---FLPEPMGTANIQLHGP 220
K G V+ EDA + G Y+C + + + + + P
Sbjct: 272 KKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVREP 331
Query: 221 --PRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSS 278
P K ++ E + E E+A +C E P T+ AW+K E+R + S+
Sbjct: 332 AVPFKKRLQDLE-VREKESATFLC--EVPQPSTEAAWFK------------EETRLWASA 376
Query: 279 SQGRSE------LHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSHLAALWP 327
G E L + N++ + D Y C + +GS + + L V+ +L P
Sbjct: 377 KYGIEEEGTERRLTVRNVSAD-DDAVYICE--TPEGS-RTVAELAVQGNLLRKLP 427
Score = 33.9 bits (76), Expect = 0.25
Identities = 61/273 (22%), Positives = 96/273 (35%), Gaps = 46/273 (16%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAAS-TISI 95
G L C G P PE W +GQ + +G R H Y + + I
Sbjct: 252 GKHARLSCYVTGEPKPETVWKKDGQ-------LVTEGRR------HVVYEDAQENFVLKI 298
Query: 96 DTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVF-TTVEDL----G 150
+ D G Y C ASN V + +V+V EP F ++DL
Sbjct: 299 LFCKQSDRGLYTCTASN-----------LVGQTYSSVLVVVREPAVPFKKRLQDLEVREK 347
Query: 151 SKILLTCSLNDSATEVTGHR-----WLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVF 205
C + +TE + W ++E+ + T V +DD Y C
Sbjct: 348 ESATFLCEVPQPSTEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDD-AVYICET 406
Query: 206 LPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKA 265
A + + G ++ + + G+TAM E PV W + ++++
Sbjct: 407 PEGSRTVAELAVQG-NLLRKLPRKTAVRVGDTAMFCV--ELAVPVGPVHWLR---NQEEV 460
Query: 266 LMNGSESRFFVSSSQGRSELHIENLNMEADPGQ 298
+ G R +S+ R L I +E D GQ
Sbjct: 461 VAGG---RVAISAEGTRHTLTISQCCLE-DVGQ 489
Score = 33.9 bits (76), Expect = 0.25
Identities = 58/242 (23%), Positives = 87/242 (35%), Gaps = 37/242 (15%)
Query: 87 QHAASTISIDTLVEEDTGTYECRASNDPDRNHLT-RAPRVKWVRAQAVVLVLEPGTVFTT 145
Q + + + L EDTG Y C + LT A V+++R V E GT
Sbjct: 3940 QGCTAELVLQDLQREDTGEYTCTCGSQATSATLTVTAAPVRFLRELQHQEVDEGGTAH-- 3997
Query: 146 VEDLGSKILLTCSLNDSATEVTGHRWLKGGVVL--------KEDALPGQKTEFKVDSDDQ 197
L C L+ + V W KG + L +D + V+ +D
Sbjct: 3998 ---------LCCELSRAGASV---EWRKGSLQLFPCAKYQMVQDGAAAELLVRGVEQEDA 4045
Query: 198 WGEYSCVFLPEPMGTANIQLHGP-PRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWY 256
G+Y+C A++ + P P+ K S G+ A L C+ W
Sbjct: 4046 -GDYTC-DTGHTQSMASLSVRVPRPKFKTRLQSLEQETGDIARLCCQLSDAESGAVVQWL 4103
Query: 257 KITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITL 316
K E L G ++ + S EL I L + D G+Y C G + +L
Sbjct: 4104 K----EGVELHAG--PKYEMRSQGATRELLIHQLEAK-DTGEYAC----VTGGQKTAASL 4152
Query: 317 RV 318
RV
Sbjct: 4153 RV 4154
Score = 33.1 bits (74), Expect = 0.43
Identities = 20/77 (25%), Positives = 36/77 (46%), Gaps = 12/77 (15%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
+G +V+L C G+P P I W+ +G+ ++D HI + + +
Sbjct: 6027 LGETVKLACRVTGTPKPVISWYKDGK-----------AVQVDPHHI-LIEDPDGSCALIL 6074
Query: 96 DTLVEEDTGTYECRASN 112
D+L D+G Y C A++
Sbjct: 6075 DSLTGVDSGQYMCFAAS 6091
Score = 31.2 bits (69), Expect = 1.6
Identities = 21/94 (22%), Positives = 34/94 (36%), Gaps = 12/94 (12%)
Query: 19 ASGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDR 78
+ A F+ +Q+ G V C G P+P ++W+ +G+ +
Sbjct: 5122 SDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGK------------LLEED 5169
Query: 79 VHIHATYHQHAASTISIDTLVEEDTGTYECRASN 112
H Q + I +V D G Y C A N
Sbjct: 5170 DHYMINEDQQGGHQLIITAVVPADMGVYRCLAEN 5203
Score = 31.2 bits (69), Expect = 1.6
Identities = 20/80 (25%), Positives = 31/80 (38%), Gaps = 13/80 (16%)
Query: 33 QRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAAST 92
Q GG+ + G P P + W+ + QL D RL + TY +
Sbjct: 6367 QAQTGGTAQFEAIIEGDPQPSVTWYKDS-------VQLVDSTRLSQQQEGTTY------S 6413
Query: 93 ISIDTLVEEDTGTYECRASN 112
+ + + +D G Y C A N
Sbjct: 6414 LVLRHVASKDAGVYTCLAQN 6433
Score = 30.8 bits (68), Expect = 2.1
Identities = 26/84 (30%), Positives = 37/84 (44%), Gaps = 9/84 (10%)
Query: 234 EGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNME 293
E ++ +L C P W YK D ++ SE +F +S +EL I L M
Sbjct: 2482 ELQSVVLSCDFRPAPKAVQW--YK-----DDTPLSPSE-KFKMSLEGQMAELRILRL-MP 2532
Query: 294 ADPGQYRCNGTSSKGSDQAIITLR 317
AD G YRC S+ S + + R
Sbjct: 2533 ADAGVYRCQAGSAHSSTEVTVEAR 2556
Score = 30.8 bits (68), Expect = 2.1
Identities = 20/76 (26%), Positives = 30/76 (39%), Gaps = 7/76 (9%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G S+ + G PVP + W E LW G + ++ QH+ + +
Sbjct: 5385 GSSITFSVKVEGRPVPTVHWLRE----EAERGVLWIGPDTPGYTVASSAQQHSLVLLDVG 5440
Query: 97 TLVEEDTGTYECRASN 112
+ GTY C ASN
Sbjct: 5441 ---RQHQGTYTCIASN 5453
Score = 29.6 bits (65), Expect = 4.8
Identities = 32/133 (24%), Positives = 53/133 (39%), Gaps = 10/133 (7%)
Query: 169 HRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTANIQLHGPPRVKAVKS 228
H + G + + PG+ F+V + G V LP+ + A PP+ A +S
Sbjct: 4573 HELVPGPECVVDGLAPGETYRFRVAAVGPVGAGEPVHLPQTVRLAEPPKPVPPQPSAPES 4632
Query: 229 SEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIE 288
+ + GE L + E V + W+K ++ G F SQGR ++ +
Sbjct: 4633 RQ-VAAGEDVSL--ELEVVAEAGEVIWHK---GMERIQPGGR----FEVVSQGRQQMLVI 4682
Query: 289 NLNMEADPGQYRC 301
D G+Y C
Sbjct: 4683 KGFTAEDQGEYHC 4695
>gi|148886752 immunoglobulin superfamily, member 9B [Homo sapiens]
Length = 1349
Score = 60.5 bits (145), Expect = 3e-09
Identities = 81/347 (23%), Positives = 136/347 (39%), Gaps = 52/347 (14%)
Query: 12 ALLGTHG--ASGAAGFVQAPLSQQRWVGGSVELHCEAV----GSPVPEIQWWFEGQGPND 65
+++GT G A GA G + P G SV L C+ + G P P + WF+ P
Sbjct: 11 SVIGTRGLAAEGAHGLREEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVP-- 68
Query: 66 TCSQLWDGARLDRVHIHATY----HQHAASTISIDTLVEEDTGTYECRA---SNDPDRNH 118
++ H+ Y H +++ ++ + ED G YEC+ D H
Sbjct: 69 --IPIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFH 126
Query: 119 LTRAPRVKWVRAQAVVLVLEPGTVFTTVEDL------GSKILLTCSLNDSATEVTGHRWL 172
WV L + FT G I +TC+ + + WL
Sbjct: 127 -----NGSWVH-----LTINAPPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIV--TWL 174
Query: 173 KGGVVL----KEDALPGQKTEFKVDSDDQWGEYSC---VFLPEPMGTANIQLHGPPRVKA 225
K G +L K G T V +D+ G Y+C E + T ++ + GPP + +
Sbjct: 175 KEGTLLGASGKYQVSDGSLTVTSVSREDR-GAYTCRAYSIQGEAVHTTHLLVQGPPFIVS 233
Query: 226 VKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSEL 285
+ +N + A+L C++E+ P + WY E+ N + R + L
Sbjct: 234 PPENITVNISQDALLTCRAEAYPGNLTYTWY--WQDENVYFQNDLKLRVRILID---GTL 288
Query: 286 HIENLNMEADPGQYRCNGTSSKG---SDQAIITLRVRSHLAALWPFL 329
I + E D G+Y C ++S G S A +T++ + + + P +
Sbjct: 289 IIFRVKPE-DSGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVI 334
Score = 47.0 bits (110), Expect = 3e-05
Identities = 54/234 (23%), Positives = 90/234 (38%), Gaps = 39/234 (16%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
GGS+ + C A G+P P + W EG + L + +Q + ++++
Sbjct: 154 GGSITMTCTAFGNPKPIVTWLKEG-------TLLGASGK----------YQVSDGSLTVT 196
Query: 97 TLVEEDTGTYECRA-SNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILL 155
++ ED G Y CRA S + H T + Q ++ P T ++ LL
Sbjct: 197 SVSREDRGAYTCRAYSIQGEAVHTTH------LLVQGPPFIVSPPENITV--NISQDALL 248
Query: 156 TCSLNDSATEVT-GHRWLKGGVVLKEDA-------LPGQKTEFKVDSDDQWGEYSCV--- 204
TC +T W V + D + G F+V +D G+Y+CV
Sbjct: 249 TCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDS-GKYTCVPSN 307
Query: 205 -FLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYK 257
P +A + + P RV + ++ G + C ++ PP T W K
Sbjct: 308 SLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNK 361
Score = 33.1 bits (74), Expect = 0.43
Identities = 27/113 (23%), Positives = 46/113 (40%), Gaps = 4/113 (3%)
Query: 92 TISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGS 151
+I I+ EE GTY C N + ++ + V + PG + ++ G
Sbjct: 381 SIRIEEATEEALGTYTCVPYNT--LGTMGQSAPARLVLKDPPYFTVLPGWEYR--QEAGR 436
Query: 152 KILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCV 204
++L+ C+ V R + K ALP +F+ S + GE+ CV
Sbjct: 437 ELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGSLQFRALSKEDHGEWECV 489
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 59.3 bits (142), Expect = 6e-09
Identities = 74/305 (24%), Positives = 116/305 (38%), Gaps = 52/305 (17%)
Query: 31 SQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAA 90
SQ G V++ C A G P P I W E Q + R+H+ A
Sbjct: 499 SQHFSQGVEVKVSCSASGYPTPHISWSRESQALQED----------SRIHVDAQ------ 542
Query: 91 STISIDTLVEEDTGTYECRASNDPDRN------HLTRAPRVKWVRAQAVVLVLEPGTVFT 144
T+ I + ED G Y C+A+N+ + + T P V V A +V V
Sbjct: 543 GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAV-------- 594
Query: 145 TVEDLGSKILLTCSLNDSATEVTGHR--WLKGG--VVLKEDALPGQKTEFKVDSDDQWGE 200
G + +L C A+ V R W +GG ++L + K + G
Sbjct: 595 -----GEEAVLVC----EASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGT 645
Query: 201 YSCVFLPEPMGTANIQLH----GPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWY 256
Y+C + E +G A+ ++ P++ + + G +A+L C++ PP T +
Sbjct: 646 YTCRAVNE-LGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPT--VTW 702
Query: 257 KITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITL 316
+ D + L G+ R S L E++ E D Y C + G QA L
Sbjct: 703 RRGDGQPLGLRLGA-GRGSRSRQPDSGVLFFESVAPE-DQAPYVCEARNVFGKVQAEARL 760
Query: 317 RVRSH 321
V H
Sbjct: 761 IVTGH 765
Score = 53.5 bits (127), Expect = 3e-07
Identities = 63/239 (26%), Positives = 92/239 (38%), Gaps = 29/239 (12%)
Query: 87 QHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTV 146
Q A ++ I ++ D G Y+C ASN N +TRA VR V + F+
Sbjct: 449 QLADLSLEISGIIPTDGGRYQCVASN---ANGVTRASVWLLVREAPQVSIHTSSQHFSQ- 504
Query: 147 EDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDA---LPGQKTEF-KVDSDDQWGEYS 202
G ++ ++CS + T W + L+ED+ + Q T + + + G YS
Sbjct: 505 ---GVEVKVSCSASGYPTPHIS--WSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYS 559
Query: 203 CVFLPE---PMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKIT 259
C E T + PP V AV + + GE A+LVC++ VPP WY+
Sbjct: 560 CQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPP-PRVIWYR-- 616
Query: 260 DSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRV 318
G +L I E D G Y C + G A I L V
Sbjct: 617 ---------GGLEMILAPEGSSSGKLRIP-AAQERDAGTYTCRAVNELGDASAEIQLAV 665
Score = 42.0 bits (97), Expect = 0.001
Identities = 74/307 (24%), Positives = 108/307 (35%), Gaps = 62/307 (20%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
+G S L C A G P P + W +G R R Q + +
Sbjct: 682 LGRSALLACRATGRPPPTVTW---RRGDGQPLGLRLGAGRGSRSR------QPDSGVLFF 732
Query: 96 DTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVL-----EPGTVFTTVEDL- 149
+++ ED Y C A N + V+A+A ++V + + TV L
Sbjct: 733 ESVAPEDQAPYVCEARNVFGK-----------VQAEARLIVTGHAPPQIASSAPTVRVLE 781
Query: 150 GSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSD--------DQWGEY 201
G + L C + + + WLK G L PG + + D + G Y
Sbjct: 782 GQPVSLPCIVL-AGRPLPERHWLKDGRPLP----PGSRHSIRADGSLHLDRALQEHAGRY 836
Query: 202 SCVFLPEPMGTANIQ-------LHGPPRVKAVKSSEHINEGETAMLVCKSESVP-PVTDW 253
SCV TA Q + PPR+ + NEG A L C + VP P W
Sbjct: 837 SCV----ATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITW 892
Query: 254 AWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAI 313
E AL S + S +G L I + + D G Y C T++ G
Sbjct: 893 T------KETNALT--SRGPHYNVSKEG--TLLIAQPSAQ-DAGAYVCTATNTVGFSSQE 941
Query: 314 ITLRVRS 320
+ L V +
Sbjct: 942 MRLSVNT 948
Score = 33.1 bits (74), Expect = 0.43
Identities = 37/153 (24%), Positives = 62/153 (40%), Gaps = 25/153 (16%)
Query: 181 DALPGQKTEFKVDSDDQW----------GEYSCVFLPEPMGT----ANIQLHGPPRVKAV 226
+A G++ F+ + W G Y C + GT A I + PP
Sbjct: 347 EARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRA-GTGRAKAQIVVTDPPPQLVP 405
Query: 227 KSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELH 286
+ ++ GETA+L C+ V A Y +T D ++ S R + L
Sbjct: 406 APNVTVSPGETAVLSCR------VLGEAPYNLTWVRDWRVLPASTGRV---AQLADLSLE 456
Query: 287 IENLNMEADPGQYRCNGTSSKGSDQAIITLRVR 319
I + + D G+Y+C +++ G +A + L VR
Sbjct: 457 ISGI-IPTDGGRYQCVASNANGVTRASVWLLVR 488
Score = 30.8 bits (68), Expect = 2.1
Identities = 22/84 (26%), Positives = 33/84 (39%), Gaps = 15/84 (17%)
Query: 29 PLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQH 88
PL G V L CEA GSP P + W + + ++ Y
Sbjct: 963 PLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNR---------------YGLL 1007
Query: 89 AASTISIDTLVEEDTGTYECRASN 112
+ ++ + + D+G YEC ASN
Sbjct: 1008 PSGSLRLAQVQVGDSGHYECTASN 1031
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 58.5 bits (140), Expect = 1e-08
Identities = 71/291 (24%), Positives = 115/291 (39%), Gaps = 57/291 (19%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G VEL C+A+G P P+ +W L D L+ + Q + + I+
Sbjct: 239 GQRVELPCKALGHPEPDYRW-------------LKDNMPLEL----SGRFQKTVTGLLIE 281
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLT 156
+ D+G+Y C SN + VK Q + + P V ++V GS++ L+
Sbjct: 282 NIRPSDSGSYVCEVSNRYGTAKVIGRLYVK----QPLKATISPRKVKSSV---GSQVSLS 334
Query: 157 CSLNDSATEVTGHRWLKGGVVLKEDALPGQKT------------EFKVDSDDQWGEYSCV 204
CS+ + TE W + G +L PG+ + V SD G Y C
Sbjct: 335 CSV--TGTEDQELSWYRNGEILN----PGKNVRITGINHENLIMDHMVKSDG--GAYQCF 386
Query: 205 FLPEPMGTAN----IQLHGPPRVKAVKSSEHINEGETAMLVCKSESVP-PVTDWAWYKIT 259
+ + + + G P++ + S + ++ E L+C + P P W T
Sbjct: 387 VRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITW-----T 441
Query: 260 DSEDKALMNGSE--SRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKG 308
+D L GS S+ S S L+I + + D G YRC +S G
Sbjct: 442 LDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVR-DGGVYRCTANNSAG 491
Score = 43.1 bits (100), Expect = 4e-04
Identities = 29/90 (32%), Positives = 42/90 (46%), Gaps = 11/90 (12%)
Query: 25 FVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWF-EGQGPNDTCSQLWDGARLDRVHIHA 83
FV P Q G +V L+C A G PVP I W F +G G + + ++
Sbjct: 692 FVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGV----------PQFQPIALNG 741
Query: 84 TYHQHAASTISIDTLVEEDTGTYECRASND 113
+ ++ I +VEED+G Y C+ SND
Sbjct: 742 RIQVLSNGSLLIKHVVEEDSGYYLCKVSND 771
Score = 37.0 bits (84), Expect = 0.030
Identities = 62/291 (21%), Positives = 110/291 (37%), Gaps = 49/291 (16%)
Query: 28 APLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQ 87
+P + VG V L C G+ E+ W+ G+ N V I H+
Sbjct: 319 SPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPG----------KNVRITGINHE 368
Query: 88 HAASTISIDTLVEEDTGTYECRASND--PDRNHL-----TRAPRVKWVRAQAVVLVLEPG 140
+ + +D +V+ D G Y+C D ++++ P++ ++ VV EP
Sbjct: 369 N----LIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPV 424
Query: 141 TVFTTVEDLGSKI-LLTCSLNDSATEVTGHRWLKGGV--VLKEDALPGQKTEFKVDSDDQ 197
++ V+ G+ + +T +L+D LKGG + + G + S Q
Sbjct: 425 SLMCNVK--GTPLPTITWTLDDDPI-------LKGGSHRISQMITSEGNVVSYLNISSSQ 475
Query: 198 ---WGEYSCVFLPEP---MGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVT 251
G Y C + A I + GP ++ +K+ I G + C+ P
Sbjct: 476 VRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAI-AGRDTYIHCRVIGY-PYY 533
Query: 252 DWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCN 302
WYK + + N + F + L + ++ E D G+Y CN
Sbjct: 534 SIKWYK---NSNLLPFNHRQVAF-----ENNGTLKLSDVQKEVDEGEYTCN 576
Score = 32.0 bits (71), Expect = 0.96
Identities = 20/74 (27%), Positives = 31/74 (41%), Gaps = 12/74 (16%)
Query: 40 VELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLV 99
+ L C+AVG P P ++W + G V I + + I T+
Sbjct: 1303 IVLPCKAVGDPSPAVKWMKDSNGTPSL------------VTIDGRRSIFSNGSFIIRTVK 1350
Query: 100 EEDTGTYECRASND 113
ED+G Y C A+N+
Sbjct: 1351 AEDSGYYSCIANNN 1364
Score = 30.0 bits (66), Expect = 3.7
Identities = 63/306 (20%), Positives = 112/306 (36%), Gaps = 53/306 (17%)
Query: 36 VGGSVELHCEAVGSPVP-EIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTIS 94
+G V + C V +P I W +G+ + G +D + S++
Sbjct: 609 IGQRVFIPCVVVSGDLPITITWQKDGRPIPGSL-----GVTIDNIDF--------TSSLR 655
Query: 95 IDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVED----LG 150
I L G Y C A N+ V Q+ ++V P D G
Sbjct: 656 ISNLSLMHNGNYTCIARNEAAA-----------VEHQSQLIVRVPPKFVVQPRDQDGIYG 704
Query: 151 SKILLTCSLNDSATEVTGHRWLKGGVV--LKEDALPGQKTEFKVDS-------DDQWGEY 201
++L CS ++ KG V + AL G+ S ++ G Y
Sbjct: 705 KAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYY 764
Query: 202 SCVFLPEPMGTANIQLHGPPRVKAVKSSEH----INEGETAMLVCKSESVPPVTDWAWYK 257
C + + ++ ++ A+ +S +G+ + C + P+ W K
Sbjct: 765 LCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIV-RWEK 823
Query: 258 ITDSEDKALMNGSESRFFVSSSQGRSELHIENLNM----EADPGQYRCNGTSSKGSDQAI 313
ED+ ++N +R+ VS+ + E+ I L + D G + C+ +S G D+ I
Sbjct: 824 ----EDR-IINPEMARYLVSTKEVGEEV-ISTLQILPTVREDSGFFSCHAINSYGEDRGI 877
Query: 314 ITLRVR 319
I L V+
Sbjct: 878 IQLTVQ 883
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 58.2 bits (139), Expect = 1e-08
Identities = 77/308 (25%), Positives = 124/308 (40%), Gaps = 63/308 (20%)
Query: 25 FVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHAT 84
F+ P S +VG + + C G+PV E W +G + S W + + HI
Sbjct: 3553 FLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSP--SPNWRISDAENKHI--- 3607
Query: 85 YHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFT 144
+ + L +D G Y C+ASN + QA +++++
Sbjct: 3608 --------LELSNLTIQDRGVYSCKASNKFGAD-----------ICQAELIIIDKPHFIK 3648
Query: 145 TVEDLGS----KILLTCSLN-DSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQ-- 197
+E + S K+ L C ++ D VT W K G L PG+ ++K+ +D+
Sbjct: 3649 ELEPVQSAINKKVHLECQVDEDRKVTVT---WSKDGQKLP----PGK--DYKICFEDKIA 3699
Query: 198 -----------WGEYSCVFLPEPMG---TANIQLHGPPR-VKAVKSSEHINEGETAMLVC 242
G Y C E +A + + PP VK V S + GE+A L C
Sbjct: 3700 TLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREPPSFVKKVDPSYLMLPGESARLHC 3759
Query: 243 KSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCN 302
K + PV W+K +K L + R + +S+ + L I ++ +E D G Y C
Sbjct: 3760 KLKG-SPVIQVTWFK----NNKELSESNTVRMYFVNSE--AILDITDVKVE-DSGSYSCE 3811
Query: 303 GTSSKGSD 310
+ GSD
Sbjct: 3812 AVNDVGSD 3819
Score = 56.2 bits (134), Expect = 5e-08
Identities = 76/302 (25%), Positives = 116/302 (38%), Gaps = 50/302 (16%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
VG SV L C+ G+P + W+ DT +L + TY + +T+
Sbjct: 6092 VGDSVSLQCQVAGTPEITVSWY-----KGDT--------KLRPTPEYRTYFTNNVATLVF 6138
Query: 96 DTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVED-LGSKIL 154
+ + D+G Y C+A N + A R Q L +E +G +
Sbjct: 6139 NKVNINDSGEYTCKAENS-----IGTASSKTVFRIQERQLPPSFARQLKDIEQTVGLPVT 6193
Query: 155 LTCSLNDSATEVTGHRWLKGGVVLKED-----ALPGQKTEFKVDSDD--QWGEYSCVFLP 207
LTC LN SA W + GV+L++D + K+ D G+YSC
Sbjct: 6194 LTCRLNGSAPIQV--CWYRDGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSC-SAS 6250
Query: 208 EPMGTANIQLHGPPR---------VKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKI 258
P+GTA+ R +K V S + GE+A C P+ +I
Sbjct: 6251 NPLGTASSSARLTAREPKKSPFFDIKPV--SIDVIAGESADFECHVTGAQPM------RI 6302
Query: 259 TDSED-KALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLR 317
T S+D K + G + ++ L I + + D GQY C T+ G D L
Sbjct: 6303 TWSKDNKEIRPG--GNYTITCVGNTPHLRILKVG-KGDSGQYTCQATNDVGKDMCSAQLS 6359
Query: 318 VR 319
V+
Sbjct: 6360 VK 6361
Score = 55.5 bits (132), Expect = 8e-08
Identities = 70/289 (24%), Positives = 121/289 (41%), Gaps = 47/289 (16%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
V G+ L C+ GS + W+ +G+ + A DR I + I +
Sbjct: 4126 VNGTCRLDCKIAGSLPMRVSWFKDGK----------EIAASDRYRIAFVEGTASLEIIRV 4175
Query: 96 DTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDL--GSKI 153
D D G + CRA+N + A V+ + V +PG+ +D+ GS +
Sbjct: 4176 DM---NDAGNFTCRATNSVGSKDSSGALIVQ----EPPSFVTKPGS-----KDVLPGSAV 4223
Query: 154 LLTCSLNDSATEVTGHRWLKGGVVL--------KEDALPGQKTEFKVDSDDQWGEYSCVF 205
L + S T +T RW KG L ++AL + V + D G Y+C
Sbjct: 4224 CLKSTFQGS-TPLT-IRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDS-GTYTCKV 4280
Query: 206 LPEPMG---TANIQLHGPPR-VKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDS 261
G +AN+ + P V+ ++ S+ + +G+ L CK PP+ W+ +
Sbjct: 4281 SNVAGGVECSANLFVKEPATFVEKLEPSQLLKKGDATQLACKVTGTPPI-KITWF----A 4335
Query: 262 EDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSD 310
D+ + S+ R +S + + L + ++ +E D G+Y C + GSD
Sbjct: 4336 NDREIKESSKHR--MSFVESTAVLRLTDVGIE-DSGEYMCEAQNEAGSD 4381
Score = 48.1 bits (113), Expect = 1e-05
Identities = 70/294 (23%), Positives = 118/294 (40%), Gaps = 36/294 (12%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
+G V C GS ++ W+ +G L D A L T H +T+ I
Sbjct: 7129 LGFPVAFECRINGSEPLQVSWYKDGV-------LLKDDANLQ------TSFVHNVATLQI 7175
Query: 96 DTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVV---LVLEPGTVFTTVEDLGS- 151
+ G Y C ASN T + K + ++ V L+P +V + + G+
Sbjct: 7176 LQTDQSHIGQYNCSASNPLG----TASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTF 7231
Query: 152 KILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKT--EFKVDSDDQWGEYSCV---FL 206
K +T + T +R ++ G K + T KV D G+Y+C
Sbjct: 7232 KCHVTGTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDA-GQYTCYASNIA 7290
Query: 207 PEPMGTANIQLHGPPR-VKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKA 265
+ +A + + PPR +K ++ S + + E CK P + WYK ++
Sbjct: 7291 GKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKV-LWYK----DETE 7345
Query: 266 LMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVR 319
+ S+ R S E+H NL++E D G Y C ++ GS + +L+V+
Sbjct: 7346 IQESSKFRMSFVDSVAVLEMH--NLSVE-DSGDYTCEAHNAAGSASSSTSLKVK 7396
Score = 48.1 bits (113), Expect = 1e-05
Identities = 62/289 (21%), Positives = 112/289 (38%), Gaps = 50/289 (17%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G SV + C+ GSP + W+ EG +++ G + + T ++++
Sbjct: 7696 GSSVVMECKVYGSPPISVSWFHEG-------NEISSGRK------YQTTLTDNTCALTVN 7742
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLT 156
L E D+G Y C A+N + + V+ + V +P V T G+ + T
Sbjct: 7743 MLEESDSGDYTCIATNMAGSDECSAPLTVR--EPPSFVQKPDPMDVLT-----GTNVTFT 7795
Query: 157 CSLNDSATEVTGHRWLKGGVVLKEDALPGQKTE------------FKVDSDDQWGEYSCV 204
+ T W KG + +PG + F VD+ Q GEY+C+
Sbjct: 7796 SIV--KGTPPFSVSWFKG----SSELVPGDRCNVSLEDSVAELELFDVDT-SQSGEYTCI 7848
Query: 205 FLPE---PMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDS 261
E T ++ + P + + I +G+ +L PP++ W K
Sbjct: 7849 VSNEAGKASCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEGTFTGTPPIS-VTWKK---- 7903
Query: 262 EDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSD 310
+ R +++++ + L I + +E D GQY C ++ G D
Sbjct: 7904 --NGINVTPSQRCNITTTEKSAILEIPSSTVE-DAGQYNCYIENASGKD 7949
Score = 47.8 bits (112), Expect = 2e-05
Identities = 71/309 (22%), Positives = 117/309 (37%), Gaps = 64/309 (20%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
+G L C+ G+P I W+ E +L + ++ +++ I
Sbjct: 7033 IGEPATLQCKVDGTPEIRISWYKEH-------------TKLRSAPAYKMQFKNNVASLVI 7079
Query: 96 DTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLV----LEP---GTVFTTVED 148
+ + D G Y C+A N V V + AV+++ L P + E
Sbjct: 7080 NKVDHSDVGEYSCKADNS-----------VGAVASSAVLVIKARKLPPFFARKLKDVHET 7128
Query: 149 LGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEF-------KVDSDDQ--WG 199
LG + C +N S E W K GV+LK+DA +T F ++ DQ G
Sbjct: 7129 LGFPVAFECRINGS--EPLQVSWYKDGVLLKDDA--NLQTSFVHNVATLQILQTDQSHIG 7184
Query: 200 EYSCVFLPEPMGTAN-------IQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTD 252
+Y+C P+GTA+ + PP S + GE+ C P+
Sbjct: 7185 QYNC-SASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPI-- 7241
Query: 253 WAWYKITDSEDKALM--NGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSD 310
KIT ++D + G+ V ++ + L + + D GQY C ++ G D
Sbjct: 7242 ----KITWAKDNREIRPGGNYKMTLVENTATLTVLKVG----KGDAGQYTCYASNIAGKD 7293
Query: 311 QAIITLRVR 319
L V+
Sbjct: 7294 SCSAQLGVQ 7302
Score = 47.0 bits (110), Expect = 3e-05
Identities = 67/312 (21%), Positives = 116/312 (37%), Gaps = 64/312 (20%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
VG S L C+ G+P + W+ DT +L + + ++ +T+
Sbjct: 7974 VGDSASLQCQLAGTPEIGVSWY-----KGDT--------KLRPTTTYKMHFRNNVATLVF 8020
Query: 96 DTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLE---PGTVFTTVEDL--- 149
+ + D+G Y C+A N V V A + V E P + + D+
Sbjct: 8021 NQVDINDSGEYICKAENS-----------VGEVSASTFLTVQEQKLPPSFSRQLRDVQET 8069
Query: 150 -GSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEF----------KVDSDDQW 198
G ++ C++ S +E W K G LK+ P +T F K D
Sbjct: 8070 VGLPVVFDCAI--SGSEPISVSWYKDGKPLKDS--PNVQTSFLDNTATLNIFKTDRSLA- 8124
Query: 199 GEYSCVFLPEPMGTANIQLH-------GPPRVKAVKSSEHINEGETAMLVCKSESVPPV- 250
G+YSC P+G+A+ PP + GE+A C P+
Sbjct: 8125 GQYSCT-ATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPIK 8183
Query: 251 TDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSD 310
WA + + + +G ++ +S + + L + ++ + D GQY C + G D
Sbjct: 8184 VSWA------KDSREIRSGG--KYQISYLENSAHLTVLKVD-KGDSGQYTCYAVNEVGKD 8234
Query: 311 QAIITLRVRSHL 322
L ++ L
Sbjct: 8235 SCTAQLNIKERL 8246
Score = 45.4 bits (106), Expect = 8e-05
Identities = 67/293 (22%), Positives = 115/293 (39%), Gaps = 40/293 (13%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G S LHC+ GSPV ++ W+ + L + Y ++ + + I
Sbjct: 3752 GESARLHCKLKGSPVIQVTWFKNNK-------------ELSESNTVRMYFVNSEAILDIT 3798
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLT 156
+ ED+G+Y C A ND + + +K + + LEP + G+ LL
Sbjct: 3799 DVKVEDSGSYSCEAVNDVGSDSCSTEIVIK--EPPSFIKTLEPADIVR-----GTNALLQ 3851
Query: 157 CSLNDSAT-EVTGHRWLKGGVVLKEDALPGQKT-----EFKVDSDDQWGEYSCVFLPEPM 210
C ++ + E++ + K K+ L QK+ F +S D GEY CV E
Sbjct: 3852 CEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVCLEIFSFNSADV-GEYECVVANEVG 3910
Query: 211 GTANIQLH----GPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKAL 266
+ H P VK V + G+T L P++ W K +
Sbjct: 3911 KCGCMATHLLKEPPTFVKKVDDLIALG-GQTVTLQAAVRGSEPIS-VTWMKGQE------ 3962
Query: 267 MNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVR 319
+ + + +S S G + L I ++ + G+Y C + GS ++ L V+
Sbjct: 3963 VIREDGKIKMSFSNGVAVLIIPDVQISFG-GKYTCLAENEAGSQTSVGELIVK 4014
Score = 45.1 bits (105), Expect = 1e-04
Identities = 68/323 (21%), Positives = 128/323 (39%), Gaps = 75/323 (23%)
Query: 25 FVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEG----QGPNDTCSQLWDGARLDRVH 80
F+ P QQ +VE G+P +I+W+ + GP C +G+
Sbjct: 5332 FLVKPGRQQAIPDSTVEFKAILKGTPPFKIKWFKDDVELVSGPK--CFIGLEGS------ 5383
Query: 81 IHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPG 140
S +++ ++ TG Y C +ND + T ++LV EP
Sbjct: 5384 ---------TSFLNLYSVDASKTGQYTCHVTNDVGSDSCT-----------TMLLVTEPP 5423
Query: 141 TVFTTVE-----DLGSKILLTCSLNDS---------------ATEVTGHRWLKGGVVLKE 180
+E G L C + S A++ ++ V++
Sbjct: 5424 KFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQM 5483
Query: 181 DALPGQKT-EFKVDSDDQWGEYSC---VFLPEPMGTANIQLHGPPRVKAVKSSEHINEGE 236
+ L + + +F ++ + G SC V + EP ++ PP V+ +K++E
Sbjct: 5484 NNLSTEDSGDFICEAQNPAGSTSCSTKVIVKEPPVFSSF----PPIVETLKNAE------ 5533
Query: 237 TAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADP 296
L C+ PP + WYK DK + S+ ++ ++S + +HI N++ +D
Sbjct: 5534 -VSLECELSGTPPF-EVVWYK-----DKRQLRSSK-KYKIASKNFHTSIHILNVDT-SDI 5584
Query: 297 GQYRCNGTSSKGSDQAIITLRVR 319
G+Y C + GSD + T++++
Sbjct: 5585 GEYHCKAQNEVGSDTCVCTVKLK 5607
Score = 44.7 bits (104), Expect = 1e-04
Identities = 61/259 (23%), Positives = 104/259 (40%), Gaps = 43/259 (16%)
Query: 80 HIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEP 139
+I +Y ++ A T+ + + G Y C+ ND A + VLEP
Sbjct: 7538 NIWISYSENIA-TLQFSRVEPANAGKYTCQIKNDAGMQECF-----------ATLSVLEP 7585
Query: 140 GTVFTTVEDLGSKILLTCSLNDSA--TEVTGHRWLKGGVVLKED---------ALPGQKT 188
T+ E + TC+L + T +W K G L D + G K
Sbjct: 7586 ATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSGLKI 7645
Query: 189 EFKVDSDDQWGEYSCVFLPEPMG----TANIQLHG----PPRVKAVKSSEHINEGETAML 240
SD G YS + P+G TA++Q+ P + +K + ++ G + ++
Sbjct: 7646 INVAPSDS--GVYSFE-VQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLS-GSSVVM 7701
Query: 241 VCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYR 300
CK PP++ +W+ E + +G ++ + + L + N+ E+D G Y
Sbjct: 7702 ECKVYGSPPISV-SWFH----EGNEISSGR--KYQTTLTDNTCALTV-NMLEESDSGDYT 7753
Query: 301 CNGTSSKGSDQAIITLRVR 319
C T+ GSD+ L VR
Sbjct: 7754 CIATNMAGSDECSAPLTVR 7772
Score = 44.3 bits (103), Expect = 2e-04
Identities = 67/303 (22%), Positives = 115/303 (37%), Gaps = 43/303 (14%)
Query: 29 PLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQH 88
P+S G S + C G+ I W + + ++ G + T H
Sbjct: 6277 PVSIDVIAGESADFECHVTGAQPMRITWSKDNK-------EIRPGGNYTITCVGNTPH-- 6327
Query: 89 AASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVED 148
+ I + + D+G Y C+A+ND ++ + VK V LE + V
Sbjct: 6328 ----LRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVK--EPPKFVKKLEA----SKVAK 6377
Query: 149 LGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQK--------TEFKVDSDDQWGE 200
G I L C ++ S W + L E T + ++D G+
Sbjct: 6378 QGESIQLECKISGSPEIKVS--WFRNDSELHESWKYNMSFINSVALLTINEASAEDS-GD 6434
Query: 201 YSCVF---LPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYK 257
Y C + + + + + PP S +G +L C+ PP + W K
Sbjct: 6435 YICEAHNGVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPF-EVVWVK 6493
Query: 258 ITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEA-DPGQYRCNGTSSKGSDQAIITL 316
D+ + S+ +F ++S + LHI LN+EA D G+Y C T+ GSD ++
Sbjct: 6494 -----DRKQVRNSK-KFKITSKHFDTSLHI--LNLEASDVGEYHCKATNEVGSDTCSCSV 6545
Query: 317 RVR 319
+ +
Sbjct: 6546 KFK 6548
Score = 42.4 bits (98), Expect = 7e-04
Identities = 55/291 (18%), Positives = 113/291 (38%), Gaps = 36/291 (12%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G + +L C+ G+P +I W+ + ++ H + + + +
Sbjct: 4314 GDATQLACKVTGTPPIKITWFANDREIKESSK-------------HRMSFVESTAVLRLT 4360
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVK----WVRAQAVVLVLEPGTVFTTVEDLGSK 152
+ ED+G Y C A N+ +H + VK + + + VL+ V E G+
Sbjct: 4361 DVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLAEVAGTP 4420
Query: 153 ILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVFLPE---P 209
D+ +G ++ +++ + Q +F V +D GEY C E
Sbjct: 4421 PFEITWFKDNTILRSGRKY---KTFIQDHLVSLQILKF-VAADA--GEYQCRVTNEVGSS 4474
Query: 210 MGTANIQLHGPPR-VKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMN 268
+ +A + L PP +K ++S+ + G A S+P W + DS++
Sbjct: 4475 ICSARVTLREPPSFIKKIESTSSLRGGTAAFQATLKGSLPITVTW----LKDSDEIT--- 4527
Query: 269 GSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVR 319
+ ++ + L++ + ++ D G+Y C + G + L V+
Sbjct: 4528 -EDDNIRMTFENNVASLYLSGIEVKHD-GKYVCQAKNDAGIQRCSALLSVK 4576
Score = 42.4 bits (98), Expect = 7e-04
Identities = 67/321 (20%), Positives = 121/321 (37%), Gaps = 49/321 (15%)
Query: 20 SGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRV 79
S A F+ P SQ G +V CE G P PEI+W F+ P S +
Sbjct: 33131 SDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEW-FKNNLPISISSNV--------- 33180
Query: 80 HIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEP 139
+ ++ I D+G Y +A N + T + V + LV EP
Sbjct: 33181 ---SISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMV-------LPLVEEP 33230
Query: 140 G--TVFTTVEDLG-------SKILLTCSLND------SATEVTGHRWLKGGVVLKEDALP 184
V T D + ++ S + S++ + +K + +
Sbjct: 33231 SREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSS 33290
Query: 185 GQKTEFKVDSDDQWGEYSCVFLPEPMGTANIQLHG----PPRVKAVKSSEHINEGETAML 240
Q++ ++ S G + L T+ + G PP+++A+ S I+EG+ +
Sbjct: 33291 MQESFVEMSSSSFMGISNMTQLES--STSKMLKAGIRGIPPKIEALPSDISIDEGKVLTV 33348
Query: 241 VCKSESVP-PVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQY 299
C P P W+ + + + + RF + ++ + L I ++ + D G Y
Sbjct: 33349 ACAFTGEPTPEVTWS------CGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQ-DGGLY 33401
Query: 300 RCNGTSSKGSDQAIITLRVRS 320
+ + GSD A + + +RS
Sbjct: 33402 TLSLGNEFGSDSATVNIHIRS 33422
Score = 41.2 bits (95), Expect = 0.002
Identities = 63/296 (21%), Positives = 112/296 (37%), Gaps = 46/296 (15%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G S C+ G+P + W+ DG + + H +T I
Sbjct: 4876 GQSTTFECQITGTPKIRVSWYL-------------DGNEITAIQKHGISFIDGLATFQIS 4922
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLT 156
E++GTY C A ND + +VK + L+P V S + L
Sbjct: 4923 GARVENSGTYVCEARNDAGTASCSIELKVK--EPPTFIRELKPVEVVKY-----SDVELE 4975
Query: 157 CSLNDSAT-EVTGHRWLKGGVVL---KEDALPGQKTEF-----KVDSDDQWGEYSCVFLP 207
C + + EVT WLK + K+ L + + F K D D GEY C+
Sbjct: 4976 CEVTGTPPFEVT---WLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDT-GEYQCIVSN 5031
Query: 208 EPMG---TANIQLHGPPR-VKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSED 263
E + + L PP +K ++++ + + + S PP++ IT +D
Sbjct: 5032 EGGSCSCSTRVALKEPPSFIKKIENTTTVLKSSATFQSTVAGS-PPIS------ITWLKD 5084
Query: 264 KALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVR 319
+++ + ++S + L I +++ G+Y C + G ++ L V+
Sbjct: 5085 DQILD-EDDNVYISFVDSVATLQIRSVD-NGHSGRYTCQAKNESGVERCYAFLLVQ 5138
Score = 40.0 bits (92), Expect = 0.004
Identities = 60/301 (19%), Positives = 117/301 (38%), Gaps = 37/301 (12%)
Query: 29 PLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQH 88
P+S +G S C G+ +I W + + ++ G + T
Sbjct: 7218 PVSVDLALGESGTFKCHVTGTAPIKITWAKDNR-------EIRPGGNYKMTLVENT---- 7266
Query: 89 AASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTV-----F 143
+T+++ + + D G Y C ASN ++ + V+ + LEP + F
Sbjct: 7267 --ATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQ--EPPRFIKKLEPSRIVKQDEF 7322
Query: 144 TTVE-DLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYS 202
T E +G + TE+ + V L E S + G+Y+
Sbjct: 7323 TRYECKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVL-----EMHNLSVEDSGDYT 7377
Query: 203 CVF---LPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKIT 259
C + ++++ PP + +G L C+ + PP +WYK
Sbjct: 7378 CEAHNAAGSASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPF-HVSWYK-- 7434
Query: 260 DSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVR 319
+ + L +G ++ + S + +HI N++ AD G+Y+C T+ GSD + ++ ++
Sbjct: 7435 --DKRELRSGK--KYKIMSENFLTSIHILNVDA-ADIGEYQCKATNDVGSDTCVGSIALK 7489
Query: 320 S 320
+
Sbjct: 7490 A 7490
Score = 39.7 bits (91), Expect = 0.005
Identities = 63/297 (21%), Positives = 118/297 (39%), Gaps = 43/297 (14%)
Query: 25 FVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHAT 84
F + + +G S+ + C+ GS QW+ +G+ + +
Sbjct: 5239 FTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEISTSAK------------YRLV 5286
Query: 85 YHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFT 144
H+ + S + ++ L EDT Y C+ SN + + VK + V + +
Sbjct: 5287 CHERSVS-LEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLVKPGRQQAIPDS 5345
Query: 145 TVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKED-----ALPGQKTEFKVDSDD--Q 197
TVE K +L T +W K V L L G + + S D +
Sbjct: 5346 TVE---FKAIL------KGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASK 5396
Query: 198 WGEYSCVFLPEPMG----TANIQLHGPPR-VKAVKSSEHINEGETAMLVCKSESVPPVTD 252
G+Y+C + +G T + + PP+ VK +++S+ + G+++ L CK P +
Sbjct: 5397 TGQYTC-HVTNDVGSDSCTTMLLVTEPPKFVKKLEASKIVKAGDSSRLECKIAGSPEIR- 5454
Query: 253 WAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGS 309
W++ +E + + F+ S + + + NL+ E D G + C + GS
Sbjct: 5455 VVWFR---NEHELPASDKYRMTFIDSV---AVIQMNNLSTE-DSGDFICEAQNPAGS 5504
Score = 37.4 bits (85), Expect = 0.023
Identities = 65/294 (22%), Positives = 98/294 (33%), Gaps = 56/294 (19%)
Query: 22 AAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHI 81
AA + P S + G S C+ G PVP + W +GQ L AR
Sbjct: 32560 AARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQ-------VLSTSAR------ 32606
Query: 82 HATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGT 141
H ST I ++ D G Y N + ++ R + P
Sbjct: 32607 HQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPP-- 32664
Query: 142 VFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEY 201
V+ ++ S V + +K A+ +T
Sbjct: 32665 ---RVKSPEPRV-------KSPEAVKSPKRVKSPEPSHPKAVSPTET------------- 32701
Query: 202 SCVFLPEPMGTANIQ---LHGPPRVKAVKSSEHINEGETAMLVCKSE-SVPPVTDWAWYK 257
+P T +Q + PP++ +E E A L C E SV + WYK
Sbjct: 32702 ------KPTPTEKVQHLPVSAPPKITQFLKAE--ASKEIAKLTCVVESSVLRAKEVTWYK 32753
Query: 258 ITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQ 311
+ K L +F S+ G EL I NL E+D G+Y C + G+ +
Sbjct: 32754 ----DGKKLKENGHFQFHY-SADGTYELKINNLT-ESDQGEYVCEISGEGGTSK 32801
Score = 37.0 bits (84), Expect = 0.030
Identities = 61/294 (20%), Positives = 113/294 (38%), Gaps = 58/294 (19%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
+G SV L C GS + W+ +G +++ G + +++ ++ T+++
Sbjct: 6754 LGASVVLECRVSGSAPISVGWFQDG-------NEIVSGPKCQ-----SSFSENVC-TLNL 6800
Query: 96 DTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDL----GS 151
L DTG Y C A+N + AV+ V EP + T + + G
Sbjct: 6801 SLLEPSDTGIYTCVAANVAGSD-----------ECSAVLTVQEPPSFEQTPDSVEVLPGM 6849
Query: 152 KILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVD-----------SDDQWGE 200
+ T + T +W KG + +PG+ ++ + G+
Sbjct: 6850 SLTFTSVIR--GTPPFKVKWFKG----SRELVPGESCNISLEDFVTELELFEVQPLESGD 6903
Query: 201 YSCVFLPEPMGTANIQLH----GPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWY 256
YSC+ + G+A+ H P + + G +L PP++ +W
Sbjct: 6904 YSCL-VTNDAGSASCTTHLFVKEPATFVKRLADFSVETGSPIVLEATYTGTPPIS-VSWI 6961
Query: 257 KITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSD 310
K D+ L++ SE R ++ ++ + L I +E D QY C + G D
Sbjct: 6962 K-----DEYLISQSE-RCSITMTEKSTILEILESTIE-DYAQYSCLIENEAGQD 7008
Score = 36.6 bits (83), Expect = 0.039
Identities = 64/285 (22%), Positives = 104/285 (36%), Gaps = 39/285 (13%)
Query: 44 CEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLVEEDT 103
C+ GSP ++ W+ ++T Q R+ V A H S ED+
Sbjct: 7327 CKIGGSPEIKVLWY-----KDETEIQESSKFRMSFVDSVAVLEMHNLSV--------EDS 7373
Query: 104 GTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCSLNDS- 162
G Y C A N + + +VK + + +P + T G+ + L C L +
Sbjct: 7374 GDYTCEAHNAAGSASSSTSLKVK----EPPIFRKKPHPIETL---KGADVHLECELQGTP 7426
Query: 163 ---ATEVTGHRWLKGG---VVLKEDALPGQKTEFKVDSDDQWGEYSCVF---LPEPMGTA 213
+ R L+ G ++ E+ L VD+ D GEY C +
Sbjct: 7427 PFHVSWYKDKRELRSGKKYKIMSENFLTSIHI-LNVDAAD-IGEYQCKATNDVGSDTCVG 7484
Query: 214 NIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESR 273
+I L PPR S G+ L E P++ W+K DK +
Sbjct: 7485 SIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGAEPIS-VVWFK-----DKGEIVRESDN 7538
Query: 274 FFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRV 318
++S S+ + L + A+ G+Y C + G + TL V
Sbjct: 7539 IWISYSENIATLQFSRVE-PANAGKYTCQIKNDAGMQECFATLSV 7582
Score = 36.6 bits (83), Expect = 0.039
Identities = 20/78 (25%), Positives = 37/78 (47%), Gaps = 13/78 (16%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
+G + +L C+ VG P+P+I+W+ G+ L + + T+++
Sbjct: 30546 LGEAAQLSCQIVGRPLPDIKWYRFGK-------------ELIQSRKYKMSSDGRTHTLTV 30592
Query: 96 DTLVEEDTGTYECRASND 113
T +ED G Y C A+N+
Sbjct: 30593 MTEEQEDEGVYTCIATNE 30610
Score = 34.7 bits (78), Expect = 0.15
Identities = 69/330 (20%), Positives = 124/330 (37%), Gaps = 63/330 (19%)
Query: 17 HGASGAAG------------FVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPN 64
H A+G+A F + P + G V L CE G+P + W+ + +
Sbjct: 7381 HNAAGSASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKR--- 7437
Query: 65 DTCSQLWDGARLDRVHIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRN------H 118
+L G + + ++ ++I I + D G Y+C+A+ND +
Sbjct: 7438 ----ELRSGKK------YKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIA 7487
Query: 119 LTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVL 178
L PR + +V + + TT+E G++ + D KG +V
Sbjct: 7488 LKAPPRFVKKLSDISTVVGKEVQLQTTIE--GAEPISVVWFKD-----------KGEIVR 7534
Query: 179 KEDALPGQKTE------FKVDSDDQWGEYSCVFLPEPMGT----ANIQLHGPPRVKAVKS 228
+ D + +E F G+Y+C + G A + + P +
Sbjct: 7535 ESDNIWISYSENIATLQFSRVEPANAGKYTCQ-IKNDAGMQECFATLSVLEPATIVEKPE 7593
Query: 229 SEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIE 288
S + G+T L C P ++ W+K + K L S++++ +S S L I
Sbjct: 7594 SIKVTTGDTCTLECTVAGTPELST-KWFK----DGKELT--SDNKYKISFFNKVSGLKII 7646
Query: 289 NLNMEADPGQYRCNGTSSKGSDQAIITLRV 318
N+ +D G Y + G D +L+V
Sbjct: 7647 NV-APSDSGVYSFEVQNPVGKDSCTASLQV 7675
Score = 34.3 bits (77), Expect = 0.19
Identities = 21/76 (27%), Positives = 35/76 (46%), Gaps = 12/76 (15%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G V HC+ G P+P+I W+ +G+ ++ G R + Q +++ I
Sbjct: 1305 GMGVTFHCKMSGYPLPKIAWYKDGK-------RIKHGER-----YQMDFLQDGRASLRIP 1352
Query: 97 TLVEEDTGTYECRASN 112
++ ED G Y ASN
Sbjct: 1353 VVLPEDEGIYTAFASN 1368
Score = 34.3 bits (77), Expect = 0.19
Identities = 63/291 (21%), Positives = 106/291 (36%), Gaps = 52/291 (17%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
+G S L C+ GS + W+ E +++ GA+ + T T+ +
Sbjct: 5813 LGASCILECKVAGSSPISVAWFHEK-------TKIVSGAK------YQTTFSDNVCTLQL 5859
Query: 96 DTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDL----GS 151
++L D G Y C A+N + +AV+ V EP + E L G
Sbjct: 5860 NSLDSSDMGNYTCVAANVAGSD-----------ECRAVLTVQEPPSFVKEPEPLEVLPGK 5908
Query: 152 KILLTCSLNDSATEVTGHRWLKGGVVLK---------EDALPGQKTEFKVDSDDQWGEYS 202
+ T + T W +G L ED + + F +D Q GEY+
Sbjct: 5909 NVTFTSVIR--GTPPFKVNWFRGARELVKGDRCNIYFEDTV-AELELFNIDI-SQSGEYT 5964
Query: 203 CVF---LPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKIT 259
CV + T + + P S + G++ +L P++ +T
Sbjct: 5965 CVVSNNAGQASCTTRLFVKEPAAFLKRLSDHSVEPGKSIILESTYTGTLPIS------VT 6018
Query: 260 DSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSD 310
+D + SE V++ + L I N + + D GQY C + G D
Sbjct: 6019 WKKDGFNITTSEKCNIVTTEK-TCILEILN-STKRDAGQYSCEIENEAGRD 6067
Score = 33.1 bits (74), Expect = 0.43
Identities = 61/295 (20%), Positives = 105/295 (35%), Gaps = 43/295 (14%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G ++L C GS IQW+ + Q + S+ + ++H + A + I
Sbjct: 4689 GSFIDLECIVAGSHPISIQWFKDDQ--EISASEKYK----------FSFHDNTAF-LEIS 4735
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLT 156
L D+GTY C A+N N + VK + V +P + +D+ +
Sbjct: 4736 QLEGTDSGTYTCSATNKAGHNQCSGHLTVK----EPPYFVEKPQS-----QDVNPNTRVQ 4786
Query: 157 CSLNDSATEVTGHRWLKGGVVLKEDAL-------PGQKTEFKVDSDDQWGEYSCVFLPEP 209
T +W K L A E G Y C L
Sbjct: 4787 LKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQ-LSND 4845
Query: 210 MGT----ANIQLHGPPR-VKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDK 264
+GT A + + PP+ +K + G++ C+ P + +WY + +E
Sbjct: 4846 VGTATSKATLFVKEPPQFIKKPSPVLVLRNGQSTTFECQITGTPKIR-VSWY-LDGNEIT 4903
Query: 265 ALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVR 319
A+ + +S G + I +E + G Y C + G+ I L+V+
Sbjct: 4904 AI-----QKHGISFIDGLATFQISGARVE-NSGTYVCEARNDAGTASCSIELKVK 4952
Score = 33.1 bits (74), Expect = 0.43
Identities = 62/294 (21%), Positives = 118/294 (40%), Gaps = 37/294 (12%)
Query: 25 FVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHAT 84
FV+ P SQ V+L G+ I+W+ + + +L GA +
Sbjct: 4770 FVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDNK-------ELHSGAA------RSV 4816
Query: 85 YHQHAASTISIDTLVEEDTGTYECRASND----PDRNHLTRAPRVKWVRAQAVVLVLEPG 140
+ ++++ + D+GTY C+ SND + L ++++ + VLVL G
Sbjct: 4817 WKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKEPPQFIKKPSPVLVLRNG 4876
Query: 141 TVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGE 200
T + + S E+T + K G+ + Q + +V++ G
Sbjct: 4877 QSTTFECQITGTPKIRVSWYLDGNEITAIQ--KHGISFIDGLATFQISGARVENS---GT 4931
Query: 201 YSCVFLPEPMGTAN----IQLHGPPR-VKAVKSSEHINEGETAMLVCKSESVPPVTDWAW 255
Y C GTA+ +++ PP ++ +K E + + L C+ PP + W
Sbjct: 4932 YVCE-ARNDAGTASCSIELKVKEPPTFIRELKPVEVVKYSDVE-LECEVTGTPPF-EVTW 4988
Query: 256 YKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGS 309
K + E + S ++ ++ LHI + +D G+Y+C ++ GS
Sbjct: 4989 LK-NNREIR-----SSKKYTLTDRVSVFNLHITKCD-PSDTGEYQCIVSNEGGS 5035
Score = 32.7 bits (73), Expect = 0.57
Identities = 22/77 (28%), Positives = 36/77 (46%), Gaps = 9/77 (11%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQL-WDGARLDRVHIHATYHQHAASTISI 95
G V + + G P+P+I+W N+T + D ++ + + + A + +SI
Sbjct: 15413 GEPVHIPADVTGLPMPKIEW-----SKNETVIEKPTDALQITKEEVSRS---EAKTELSI 15464
Query: 96 DTLVEEDTGTYECRASN 112
V ED GTY ASN
Sbjct: 15465 PKAVREDKGTYTVTASN 15481
Score = 32.3 bits (72), Expect = 0.74
Identities = 14/39 (35%), Positives = 20/39 (51%)
Query: 18 GASGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQW 56
G A F+ P+ Q+ GGSV C+ G+P P + W
Sbjct: 1077 GEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYW 1115
Score = 32.3 bits (72), Expect = 0.74
Identities = 61/281 (21%), Positives = 107/281 (38%), Gaps = 42/281 (14%)
Query: 31 SQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAA 90
SQ G VG P PE +W+ G R DR++ + + +
Sbjct: 2086 SQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIE----------RSDRIYWY--WPEDNV 2133
Query: 91 STISIDTLVEEDTGTYECRASN--DPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVED 148
+ I + ED+ + +A N +H + K Q + E V +D
Sbjct: 2134 CELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAK----QLITFTQELQDVVAKEKD 2189
Query: 149 LGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKV--------DSDDQWGE 200
+ C ++ +V +W K G+ + E ++ KV D+ D +
Sbjct: 2190 --TMATFECETSEPFVKV---KWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDA-ED 2243
Query: 201 YSCVFLPEP--MGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKI 258
YSCV + + TA + + G V+ VK + I E+ + P + WY
Sbjct: 2244 YSCVLVEDENVKTTAKLIVEGAV-VEFVKELQDIEVPESYSGELECIVSPENIEGKWYH- 2301
Query: 259 TDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQY 299
D E K S ++ ++S +GR L ++++ E D G+Y
Sbjct: 2302 NDVELK-----SNGKYTITSRRGRQNLTVKDVTKE-DQGEY 2336
Score = 32.3 bits (72), Expect = 0.74
Identities = 27/107 (25%), Positives = 46/107 (42%), Gaps = 8/107 (7%)
Query: 212 TANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSE 271
T + +L P + S++INEG+ + C+ S P + W+K L
Sbjct: 33125 TLSKELSDAPAFISQPRSQNINEGQNVLFTCEI-SGEPSPEIEWFK------NNLPISIS 33177
Query: 272 SRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRV 318
S +S S+ L I N ++ +D G+Y + +G A +L V
Sbjct: 33178 SNVSISRSRNVYSLEIRNASV-SDSGKYTIKAKNFRGQCSATASLMV 33223
Score = 32.0 bits (71), Expect = 0.96
Identities = 35/129 (27%), Positives = 46/129 (35%), Gaps = 32/129 (24%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
GGS +H G P PEI W E +G D+V I + + +SID
Sbjct: 24039 GGSARIHIPFKGRPTPEITWSRE------------EGEFTDKVQIEKGVNY---TQLSID 24083
Query: 97 TLVEEDTGTYECRASNDPDRNHL--------TRAP----RVKWVRAQAVVLVLEPGTVFT 144
D G Y + N T P VK VR + LV EP +
Sbjct: 24084 NCDRNDAGKYILKLENSSGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPII-- 24141
Query: 145 TVEDLGSKI 153
D G+K+
Sbjct: 24142 ---DGGAKV 24147
Score = 31.2 bits (69), Expect = 1.6
Identities = 18/71 (25%), Positives = 33/71 (46%), Gaps = 11/71 (15%)
Query: 42 LHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLVEE 101
L C+ G P P ++W+ +G+ + DG + YHQ + I ++ ++
Sbjct: 30947 LVCKVTGHPKPIVKWYRQGK------EIIADGLKYRIQEFKGGYHQ-----LIIASVTDD 30995
Query: 102 DTGTYECRASN 112
D Y+ RA+N
Sbjct: 30996 DATVYQVRATN 31006
Score = 30.8 bits (68), Expect = 2.1
Identities = 22/89 (24%), Positives = 34/89 (38%), Gaps = 13/89 (14%)
Query: 25 FVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHAT 84
F Q P G V L CE G+P E+ W + D ++
Sbjct: 6460 FTQKPSPVGALKGSDVILQCEISGTPPFEVVW-------------VKDRKQVRNSKKFKI 6506
Query: 85 YHQHAASTISIDTLVEEDTGTYECRASND 113
+H +++ I L D G Y C+A+N+
Sbjct: 6507 TSKHFDTSLHILNLEASDVGEYHCKATNE 6535
Score = 30.8 bits (68), Expect = 2.1
Identities = 22/90 (24%), Positives = 40/90 (44%), Gaps = 15/90 (16%)
Query: 234 EGETAMLVCKSESVPPVTDWAWY----KITDSEDKALMNGSESRFFVSSSQGRSELHIEN 289
EG VCK E+ T WY ++ +SE ++ ++ G + L++++
Sbjct: 31581 EGGHVKYVCKIENYDQSTQVTWYFGVRQLENSE----------KYEITYEDGVAILYVKD 31630
Query: 290 LNMEADPGQYRCNGTSSKGSDQAIITLRVR 319
+ + D G YRC + G D + L V+
Sbjct: 31631 IT-KLDDGTYRCKVVNDYGEDSSYAELFVK 31659
Score = 30.4 bits (67), Expect = 2.8
Identities = 19/85 (22%), Positives = 35/85 (41%), Gaps = 13/85 (15%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
VG + L C+ G+P ++W+ DG L H + S++ I
Sbjct: 5717 VGETCTLECKVAGTPELSVEWY-------------KDGKLLTSSQKHKFSFYNKISSLRI 5763
Query: 96 DTLVEEDTGTYECRASNDPDRNHLT 120
++ +D GTY + N+ ++ T
Sbjct: 5764 LSVERQDAGTYTFQVQNNVGKSSCT 5788
Score = 30.4 bits (67), Expect = 2.8
Identities = 21/78 (26%), Positives = 32/78 (41%), Gaps = 17/78 (21%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQG--PNDTCSQLWDGARLDRVHIHATYHQHAASTIS 94
G V+L C GS IQW G+ P+D CS + + +
Sbjct: 8360 GEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFASG---------------TAVLE 8404
Query: 95 IDTLVEEDTGTYECRASN 112
+ + + D+G Y C+ASN
Sbjct: 8405 LRDVAKADSGDYVCKASN 8422
Score = 30.4 bits (67), Expect = 2.8
Identities = 21/76 (27%), Positives = 35/76 (46%), Gaps = 13/76 (17%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G S ++ + G P+P IQW Q ++T R+ I +T A+++S+
Sbjct: 22558 GESFKVDADIYGKPIPTIQWIKGDQELSNTA----------RLEIKST---DFATSLSVK 22604
Query: 97 TLVEEDTGTYECRASN 112
V D+G Y +A N
Sbjct: 22605 DAVRVDSGNYILKAKN 22620
Score = 30.0 bits (66), Expect = 3.7
Identities = 37/153 (24%), Positives = 58/153 (37%), Gaps = 19/153 (12%)
Query: 161 DSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTA-----NI 215
DSA + + +K L + EF+V ++++ G L P TA +
Sbjct: 30474 DSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFAENETG------LSRPRRTAMSIKTKL 30527
Query: 216 QLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFF 275
P ++ GE A L C+ P+ D WY+ K L+ +SR +
Sbjct: 30528 TSGEAPGIRKEMKDVTTKLGEAAQLSCQIVG-RPLPDIKWYRF----GKELI---QSRKY 30579
Query: 276 VSSSQGRSELHIENLNMEADPGQYRCNGTSSKG 308
SS GR+ + D G Y C T+ G
Sbjct: 30580 KMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVG 30612
Score = 29.3 bits (64), Expect = 6.3
Identities = 62/315 (19%), Positives = 107/315 (33%), Gaps = 53/315 (16%)
Query: 23 AGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIH 82
A ++ P G L C G+P +W+ +G+ D H H
Sbjct: 6645 ARIIEKPEPMTVTTGNPFALECVVTGTPELSAKWFKDGR-----------ELSADSKH-H 6692
Query: 83 ATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTV 142
T+ AS + I D G Y N +++ T + V + +V P +
Sbjct: 6693 ITFINKVAS-LKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHV----SDRIV----PPSF 6743
Query: 143 FTTVED----LGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSD--- 195
++D LG+ ++L C ++ SA G W + G + + G K + +
Sbjct: 6744 IRKLKDVNAILGASVVLECRVSGSAPISVG--WFQDG----NEIVSGPKCQSSFSENVCT 6797
Query: 196 --------DQWGEYSCV---FLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKS 244
G Y+CV +A + + PP + S + G +
Sbjct: 6798 LNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSVI 6857
Query: 245 ESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGT 304
PP W+K + L+ G +S +EL + + + G Y C T
Sbjct: 6858 RGTPPF-KVKWFK----GSRELVPGESCN--ISLEDFVTELELFEV-QPLESGDYSCLVT 6909
Query: 305 SSKGSDQAIITLRVR 319
+ GS L V+
Sbjct: 6910 NDAGSASCTTHLFVK 6924
Score = 28.9 bits (63), Expect = 8.2
Identities = 13/37 (35%), Positives = 20/37 (54%)
Query: 25 FVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQ 61
FV P+S + G + + VG P+PE W+ +GQ
Sbjct: 1459 FVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQ 1495
Score = 28.9 bits (63), Expect = 8.2
Identities = 54/252 (21%), Positives = 89/252 (35%), Gaps = 65/252 (25%)
Query: 72 DGARLDRVHIHATYHQHAAST--ISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVR 129
DG +L + + H +H A T + I+ L E D G Y C S + T ++++
Sbjct: 32754 DGKKL-KENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGG----TSKTNLQFM- 32807
Query: 130 AQAVVLVLEPGTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTE 189
G F ++ + SKI T + TE T R KTE
Sbjct: 32808 ----------GQAFKSIHEKVSKISETKKSDQKTTESTVTR----------------KTE 32841
Query: 190 FKVDSDDQWGEYSCVFLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVP- 248
K PEP+ + + + G ++ A K+ P
Sbjct: 32842 PKA--------------PEPISSKPVIVTG-------LQDTTVSSDSVAKFAVKATGEPR 32880
Query: 249 PVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKG 308
P W + KA+ G ++ +S +G L I + +D G Y C +S G
Sbjct: 32881 PTAIWT------KDGKAITQG--GKYKLSEDKGGFFLEIHKTD-TSDSGLYTCTVKNSAG 32931
Query: 309 SDQAIITLRVRS 320
S + L +++
Sbjct: 32932 SVSSSCKLTIKA 32943
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 57.0 bits (136), Expect = 3e-08
Identities = 80/320 (25%), Positives = 111/320 (34%), Gaps = 56/320 (17%)
Query: 14 LGTHGASGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDG 73
L HG + + P+ + VG +V L C + G P +W P
Sbjct: 3106 LSVHGPPTVSVLPEGPVWVK--VGKAVTLECVSAGEPRSSARWTRISSTP---------- 3153
Query: 74 ARLDRVHIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHL---------TRAPR 124
A+L++ + HA + I + D GTY C A N AP
Sbjct: 3154 AKLEQ-RTYGLMDSHAV--LQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPG 3210
Query: 125 VKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLK-EDAL 183
V+A+ L +E G T L CS S W K L + L
Sbjct: 3211 APQVQAEEAELTVEAGHTAT----------LRCSATGSPAPTI--HWSKLRSPLPWQHRL 3258
Query: 184 PGQKTEFKVDSDDQWGEYSC-VFLPEPMGTANIQLH--GPPRVKAVKSSEHINEGETAML 240
G + G+Y C P A I LH PP V + GET L
Sbjct: 3259 EGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQL 3318
Query: 241 VCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSE-LHIENLNMEADPGQY 299
C + PP+T + W ++ S + R+E LH E E D G+Y
Sbjct: 3319 QCLAHGTPPLT-FQWSRVGSS-------------LPGRATARNELLHFERAAPE-DSGRY 3363
Query: 300 RCNGTSSKGSDQAIITLRVR 319
RC T+ GS +A L V+
Sbjct: 3364 RCRVTNKVGSAEAFAQLLVQ 3383
Score = 44.7 bits (104), Expect = 1e-04
Identities = 80/335 (23%), Positives = 123/335 (36%), Gaps = 69/335 (20%)
Query: 12 ALLGTHGASGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLW 71
A+L HG G V +P Q G +V L+C A G P I W EG L
Sbjct: 1946 AVLHVHGGGGPRVQV-SPERTQVHAGRTVRLYCRAAGVPSATITWRKEG-------GSLP 1997
Query: 72 DGARLDRVHIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQ 131
AR +R I +T+ I + D G Y C A++ T R++ V
Sbjct: 1998 PQARSERTDI---------ATLLIPAITTADAGFYLCVATSPAG----TAQARIQVVVLS 2044
Query: 132 AVVLVLEPGTVFTTVEDL--GSKILLTCSLNDSA-TEVTGHRWLKGGVVLKEDALPGQKT 188
A P + ++ + G + L C + SA +VT +R +GG + + G +
Sbjct: 2045 ASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYR--RGGSLPPHTQVHGSRL 2102
Query: 189 EFKVDSDDQWGEYSCVFL----PEPMGTANIQLHG----------PPRVKAVK---SSEH 231
S GEY C P+ LHG P + ++ SS H
Sbjct: 2103 RLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSH 2162
Query: 232 INEGETAMLVC--KSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIEN 289
+ EG+T L C ++ VT W+K S R + H
Sbjct: 2163 VAEGQTLDLNCVVPGQAHAQVT---WHKRG-----------------GSLPARHQTHGSL 2202
Query: 290 LNME----ADPGQYRCNGTSSKGSDQAIITLRVRS 320
L + AD G+Y C+ + G +A + + + +
Sbjct: 2203 LRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEA 2237
Score = 42.4 bits (98), Expect = 7e-04
Identities = 66/300 (22%), Positives = 115/300 (38%), Gaps = 54/300 (18%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G +V+L C A G+P QW G + AR + +H +
Sbjct: 3313 GETVQLQCLAHGTPPLTFQWSRVGSSLPGRAT-----ARNELLHF--------------E 3353
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTT-------VEDL 149
ED+G Y CR +N V+ + G+ T + +
Sbjct: 3354 RAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSI 3413
Query: 150 GSKILLTCSL-NDSATEVTGHRWLKGGVVLKEDALPGQKTE---FKVDSDDQWGEYSCVF 205
G+ + C++ +D T++ RW K G L PG + ++ + DQ SC
Sbjct: 3414 GASVEFHCAVPSDRGTQL---RWFKEGGQLP----PGHSVQDGVLRIQNLDQ----SC-- 3460
Query: 206 LPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVT-----DWAWYKITD 260
GT Q HGP KA S++ + + ++L+ SV V ++ + D
Sbjct: 3461 ----QGTYICQAHGPWG-KAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGD 3515
Query: 261 SEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRS 320
+ + + Q + I ++ + AD GQYRC T++ G+ Q+ + L V++
Sbjct: 3516 PKPQVTWSKVGGHLRPGIVQSGGVVRIAHVEL-ADAGQYRCTATNAAGTTQSHVLLLVQA 3574
Score = 42.0 bits (97), Expect = 0.001
Identities = 70/312 (22%), Positives = 112/312 (35%), Gaps = 70/312 (22%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G +++L C G ++ W+ G G+ R HQ S + I
Sbjct: 2259 GQTLDLSCVVAGQAHAQVTWYKRG------------GSLPAR-------HQVRGSRLYIF 2299
Query: 97 TLVEEDTGTYECRASNDPDRNHL-----TRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGS 151
D G Y CRASN + + T+ + + + +EP + + V + G
Sbjct: 2300 QASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSS--SQVAE-GQ 2356
Query: 152 KILLTCSL-NDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVFLP--- 207
+ L C + S +VT H+ +GG + G S GEY C L
Sbjct: 2357 TLDLNCVVPGQSHAQVTWHK--RGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSV 2414
Query: 208 ----------EPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVC--KSESVPPVTDWAW 255
EP G+ L P V+ SS + EG+T L C ++ VT W
Sbjct: 2415 PLEASVLVTIEPAGSVPA-LGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVT---W 2470
Query: 256 YKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNM----EADPGQYRCNGTSSKGSDQ 311
+K S R ++H L + AD G+Y C S G+ +
Sbjct: 2471 HKRG-----------------GSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQE 2513
Query: 312 AIITLRVRSHLA 323
A + + ++ L+
Sbjct: 2514 ASVLVTIQQRLS 2525
Score = 39.3 bits (90), Expect = 0.006
Identities = 67/324 (20%), Positives = 117/324 (36%), Gaps = 61/324 (18%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G +++L+C P I W+ G G+ R HQ S + +
Sbjct: 2644 GQTLDLNCVVARQPQAIITWYKRG------------GSLPSR-------HQTHGSHLRLH 2684
Query: 97 TLVEEDTGTYECRASNDPDRNH----LTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSK 152
+ D+G Y CRA+N+ D ++ +P A + + + + V + G
Sbjct: 2685 QMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAE-GET 2743
Query: 153 ILLTCSLNDSA-TEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVFLP---- 207
+ L C + A +VT H+ +GG + G + S GEY C +
Sbjct: 2744 LDLNCVVPGQAHAQVTWHK--RGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGP 2801
Query: 208 ---------EPMGTANIQLHGP---PRVKAVKSSEHINEGETAMLVC--KSESVPPVTDW 253
E G++ + + P P ++ SS + EG+T L C ++ VT
Sbjct: 2802 LEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVT-- 2859
Query: 254 AWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAI 313
W+K + + Q L N AD G+Y C T S G+ +A
Sbjct: 2860 -WHKRGGN-------------LPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEAS 2905
Query: 314 ITLRVRSHLAALWPFLGIVAEVLV 337
+ + + P G+ + +
Sbjct: 2906 VLVTIEPSSPGPIPAPGLAQPIYI 2929
Score = 39.3 bits (90), Expect = 0.006
Identities = 70/270 (25%), Positives = 98/270 (36%), Gaps = 63/270 (23%)
Query: 77 DRVHIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLV 136
D VHI S I+I + GTY C ASN + ++ V V V
Sbjct: 3065 DNVHISPN-----GSIITIVGTRPSNHGTYRCVASN---AYGVAQSVVNLSVHGPPTVSV 3116
Query: 137 LEPGTVFTTVEDLGSKILLTCSLNDSATEV-TGHRWLKGGVVLKEDALPGQKTEFKVDSD 195
L G V+ V G + L C SA E + RW + + A Q+T +DS
Sbjct: 3117 LPEGPVWVKV---GKAVTLECV---SAGEPRSSARWTR---ISSTPAKLEQRTYGLMDSH 3167
Query: 196 ----------DQWGEYSCVFLPEPMGTANIQLH----------GPPRVKAVKSSEHINEG 235
G Y C+ +GTA Q+ G P+V+A ++ + G
Sbjct: 3168 AVLQISSAKPSDAGTYVCL-AQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAG 3226
Query: 236 ETAMLVCKSESVP-PVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNM-- 292
TA L C + P P W+ + S + L + L +
Sbjct: 3227 HTATLRCSATGSPAPTIHWSKLR-------------------SPLPWQHRLEGDTLIIPR 3267
Query: 293 --EADPGQYRCNGTSSKGSDQAIITLRVRS 320
+ D GQY CN TS G +A I L V S
Sbjct: 3268 VAQQDSGQYICNATSPAGHAEATIILHVES 3297
Score = 38.9 bits (89), Expect = 0.008
Identities = 60/254 (23%), Positives = 93/254 (36%), Gaps = 47/254 (18%)
Query: 84 TYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVF 143
++HQ S + + + D+G Y CR + ++ + AV + G
Sbjct: 2769 SHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPP 2828
Query: 144 TTVEDLGSKIL------LTCSLNDSA-TEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDD 196
+E S++ L C + A +VT H+ +GG + + G S
Sbjct: 2829 IRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHK--RGGNLPARHQVHGPLLRLNQVSPA 2886
Query: 197 QWGEYSC-------------VFLPEPMGTANIQLHG---PPRVKAVKSSEHINEGETAML 240
GEYSC + EP I G P ++A SS H+ EG+T L
Sbjct: 2887 DSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEA--SSSHVTEGQTLDL 2944
Query: 241 VC--KSESVPPVTDWAWYKITDS-EDKALMNGSESRFFVSSSQGRSELHIENLNMEADPG 297
C ++ VT WYK S + +GS+ R + S AD G
Sbjct: 2945 NCVVPGQAHAQVT---WYKRGGSLPARHQTHGSQLRLHLVS--------------PADSG 2987
Query: 298 QYRCNGTSSKGSDQ 311
+Y C S G +Q
Sbjct: 2988 EYVCRAASGPGPEQ 3001
Score = 36.6 bits (83), Expect = 0.039
Identities = 62/291 (21%), Positives = 112/291 (38%), Gaps = 50/291 (17%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G +++L+C G ++ W+ G G+ R HQ S + +
Sbjct: 2939 GQTLDLNCVVPGQAHAQVTWYKRG------------GSLPAR-------HQTHGSQLRLH 2979
Query: 97 TLVEEDTGTYECRASNDP----DRNHLTRAPRVKW--VRAQAVVLVLEPGTVFTTVEDLG 150
+ D+G Y CRA++ P + + P + R ++ V+ ++P + +TV+ G
Sbjct: 2980 LVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPS--STVQQ-G 3036
Query: 151 SKILLTCSLNDSATEV-----TGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVF 205
C ++D A + T ++ L+ V + + G G Y CV
Sbjct: 3037 QDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPN---GSIITIVGTRPSNHGTYRCV- 3092
Query: 206 LPEPMGTA----NIQLHGPPRVKAV-KSSEHINEGETAMLVCKSESVPPVTDWAWYKITD 260
G A N+ +HGPP V + + + G+ L C S P + W +I+
Sbjct: 3093 ASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAG-EPRSSARWTRISS 3151
Query: 261 SEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQ 311
+ K E R + + L I + +D G Y C ++ G+ Q
Sbjct: 3152 TPAKL-----EQRTY-GLMDSHAVLQISSAK-PSDAGTYVCLAQNALGTAQ 3195
Score = 35.4 bits (80), Expect = 0.087
Identities = 58/235 (24%), Positives = 83/235 (35%), Gaps = 22/235 (9%)
Query: 93 ISIDTLVEEDTGTYECRASN--DPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLG 150
++I + D GTY C SN D+ T + + VV + P TV+ G
Sbjct: 1825 LTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQL---TVQP-G 1880
Query: 151 SKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSC---VFLP 207
CS S T GG + + + G +Y C
Sbjct: 1881 QLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAG 1940
Query: 208 EPMGTANIQLHGP--PRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKA 265
+ + A + +HG PRV+ ++ G T L C++ VP T W K
Sbjct: 1941 QQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSAT-ITWRK-------- 1991
Query: 266 LMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRS 320
GS S + L I + AD G Y C TS G+ QA I + V S
Sbjct: 1992 -EGGSLPPQARSERTDIATLLIPAIT-TADAGFYLCVATSPAGTAQARIQVVVLS 2044
Score = 35.0 bits (79), Expect = 0.11
Identities = 73/317 (23%), Positives = 120/317 (37%), Gaps = 56/317 (17%)
Query: 12 ALLGTHGASGAAGFVQA-PLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQL 70
+L T +G+ VQ P + + +G SVE HC +++W+ EG QL
Sbjct: 3388 SLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEG-------GQL 3440
Query: 71 WDGARLDRVHIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRA 130
G H + I L + GTY C+A + +A ++A
Sbjct: 3441 PPG------------HSVQDGVLRIQNLDQSCQGTYICQAHGPWGK---AQASAQLVIQA 3485
Query: 131 QAVVLVLEPGTVFTTVEDLGSKILLTC-SLNDSATEVTGHRWLKGGVVLKEDALP--GQK 187
VL+ +V T V +G + C +L D +VT W K G L+ + G
Sbjct: 3486 LPSVLINIRTSVQTVV--VGHAVEFECLALGDPKPQVT---WSKVGGHLRPGIVQSGGVV 3540
Query: 188 TEFKVDSDDQWGEYSCVFLPEPMGTAN----IQLHGPPRVKAVKSSEHINEGETAMLVCK 243
V+ D G+Y C GT + + P++ ++ + G A+ C
Sbjct: 3541 RIAHVELADA-GQYRCT-ATNAAGTTQSHVLLLVQALPQI-SMPQEVRVPAGSAAVFPCI 3597
Query: 244 SESVPPVTDWAWYKITDS--EDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRC 301
+ P D +W K+ S D L N + L + ++ + D G Y C
Sbjct: 3598 ASGY-PTPDISWSKLDGSLPPDSRLEN--------------NMLMLPSVRPQ-DAGTYVC 3641
Query: 302 NGTSSKGSDQAIITLRV 318
T+ +G +A L+V
Sbjct: 3642 TATNRQGKVKAFAHLQV 3658
Score = 33.9 bits (76), Expect = 0.25
Identities = 65/300 (21%), Positives = 89/300 (29%), Gaps = 58/300 (19%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
GGS L C+ GSP P +W G R T +H S +
Sbjct: 1691 GGSHSLRCQVSGSP-PHYFYWSREDG---------------RPVPSGTQQRHQGSELHFP 1734
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSK---- 152
++ D G Y C N N RA+ +V + TVE+ S+
Sbjct: 1735 SVQPSDAGVYICTCRNLHQSN---------TSRAELLVTEAPSKPITVTVEEQRSQSVRP 1785
Query: 153 -----ILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCV--- 204
+ T A + R G + + G T V D G Y C
Sbjct: 1786 GADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDA-GTYVCTGSN 1844
Query: 205 FLPEPMGTANIQLHGPPRVKAVKSSEH-----INEGETAMLVCKSESVP-PVTDWAWYKI 258
GTA + + + A S H + G+ A C + P P +W
Sbjct: 1845 MFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPG 1904
Query: 259 TDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRV 318
KA ++G R D QY C SS G A L V
Sbjct: 1905 GQLPAKAQIHGGILRLPAVE--------------PTDQAQYLCRAHSSAGQQVARAVLHV 1950
Score = 32.3 bits (72), Expect = 0.74
Identities = 73/339 (21%), Positives = 119/339 (35%), Gaps = 61/339 (17%)
Query: 3 AALFVLLGFALLGTHGASGAAGFVQAPLSQQRWVGG-SVELHCEAVGSPVPEIQWWFEGQ 61
A++ V + L G+H + G A V+ S G +++L+C V S P W++
Sbjct: 2514 ASVLVTIQQRLSGSH-SQGVAYPVRIESSSASLANGHTLDLNC-LVASQAPHTITWYKRG 2571
Query: 62 GPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTR 121
G + HQ S + I + D+G Y C SN +
Sbjct: 2572 GSLPS------------------RHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSL 2613
Query: 122 APRVKWVRAQAVVLVLEP----GTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLK-GGV 176
++ + V V P + T VE G + L C + + W K GG
Sbjct: 2614 IVTIQGSGSSHVPSVSPPIRIESSSPTVVE--GQTLDLNCVVARQPQAII--TWYKRGGS 2669
Query: 177 VLKEDALPGQKTEFKVDSDDQWGEYSC-------------VFLPEPMGTANIQLHGPPRV 223
+ G S GEY C V P + +
Sbjct: 2670 LPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPI 2729
Query: 224 KAVKSSEHINEGETAMLVC--KSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQG 281
+ SS H+ EGET L C ++ VT W+K +L + ++R
Sbjct: 2730 RIESSSSHVAEGETLDLNCVVPGQAHAQVT---WHK----RGGSLPSHHQTR-------- 2774
Query: 282 RSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRS 320
S L + +++ AD G+Y C S G +A + + + +
Sbjct: 2775 GSRLRLHHVS-PADSGEYVCRVMGSSGPLEASVLVTIEA 2812
Score = 31.6 bits (70), Expect = 1.3
Identities = 79/341 (23%), Positives = 128/341 (37%), Gaps = 65/341 (19%)
Query: 15 GTHGASGA--AGFVQA----PLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCS 68
GT GA+ A AG Q P S Q G +++L+C G ++ W G
Sbjct: 2327 GTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRG-------- 2378
Query: 69 QLWDGARLDRVHIHATYHQHAASTISIDTLVEEDTGTYECR---ASNDPDRNHLTRAPRV 125
G+ R HQ S + + D+G Y CR +S + + L
Sbjct: 2379 ----GSLPVR-------HQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPA 2427
Query: 126 KWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCSLNDSA-TEVTGHRWLKGGVVLKEDALP 184
V A V + + + V + G + L C + A +VT H+ +GG + +
Sbjct: 2428 GSVPALGVTPTVRIESSSSQVAE-GQTLDLNCLVAGQAHAQVTWHK--RGGSLPARHQVH 2484
Query: 185 GQKTEFKVDSDDQWGEYSC--------------VFLPEPMGTANIQLHGPPRVKAVKSSE 230
G + + GEY C V + + + ++ Q P V+ SS
Sbjct: 2485 GSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYP-VRIESSSA 2543
Query: 231 HINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENL 290
+ G T L C S P T WYK S SR + S+ L I +
Sbjct: 2544 SLANGHTLDLNCLVASQAPHT-ITWYKRGGS--------LPSRHQIVGSR----LRIPQV 2590
Query: 291 NMEADPGQYRCNGTSSKGSDQAIITLRVR----SHLAALWP 327
AD G+Y C+ ++ GS + + + ++ SH+ ++ P
Sbjct: 2591 T-PADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSP 2630
>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
Length = 2623
Score = 57.0 bits (136), Expect = 3e-08
Identities = 75/298 (25%), Positives = 120/298 (40%), Gaps = 40/298 (13%)
Query: 42 LHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLVEE 101
L CEAVG+P+P I W +++ G L + ++ T+SI + +
Sbjct: 1668 LPCEAVGNPLPTIHW-----------TRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQ 1716
Query: 102 DTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCSLND 161
D G Y C ASN +HL V +LE T TV GS + L C
Sbjct: 1717 DRGQYLCSASNLFGTDHL----HVTLSVVSYPPRILERRTKEITVHS-GSTVELKCRAEG 1771
Query: 162 SATEVTGHRW-LKGGVVLKEDALPGQKTEFKVD--------SDDQWGEYSCVFLPEPMG- 211
+ W L V+ E + ++ VD S G Y CV P G
Sbjct: 1772 RPSPTV--TWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCV-ASNPGGQ 1828
Query: 212 ---TANIQLHGPPRVKAVKSSEHI--NEGETAMLVCKSESVPPVTDWAWYKITDSEDKAL 266
IQ+ P V + + I GE+ L C ++ P + ++ ++D +
Sbjct: 1829 DSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPS--VYWVLSDGTEVKP 1886
Query: 267 MNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSHLAA 324
+ + S+ F+ S+ L+I NL +D G Y C TSS GS++ ++ L + + +
Sbjct: 1887 LQFTNSKLFLFSN---GTLYIRNL-ASSDRGTYECIATSSTGSERRVVMLTMEERVTS 1940
Score = 47.8 bits (112), Expect = 2e-05
Identities = 74/315 (23%), Positives = 119/315 (37%), Gaps = 49/315 (15%)
Query: 30 LSQQRWV-----GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHI-HA 83
L Q+R V G S++L C A G+P P + W L DG + + ++
Sbjct: 1845 LEQRRQVIVGTWGESLKLPCTAKGTPQPSVYW------------VLSDGTEVKPLQFTNS 1892
Query: 84 TYHQHAASTISIDTLVEEDTGTYECRASNDPDRNH----LTRAPRVKWVRAQAVVLVLEP 139
+ T+ I L D GTYEC A++ LT RV R +E
Sbjct: 1893 KLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPR-------IEA 1945
Query: 140 GTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDAL-------PGQKTEFKV 192
+ T + G K+LL CS R VV ++ + P
Sbjct: 1946 ASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGS 2005
Query: 193 DSDDQWGEYSCVFLPEPMGTANIQLHGPPRVKAVKSS------EHINEGETAMLVCKSES 246
++ G Y CV MG I +H R+K K + + G+ + CK+
Sbjct: 2006 VTEKDSGVYLCV-ARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASG 2064
Query: 247 VP-PVTDWAWYKIT--DSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNG 303
P P W+ T ++ +A +G +R + + G L+ + + A+ G Y C
Sbjct: 2065 SPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGT--LYFNKVGV-AEEGDYTCYA 2121
Query: 304 TSSKGSDQAIITLRV 318
++ G D+ + L V
Sbjct: 2122 QNTLGKDEMKVHLTV 2136
Score = 41.6 bits (96), Expect = 0.001
Identities = 23/76 (30%), Positives = 31/76 (40%), Gaps = 9/76 (11%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G + +LHC A+G P PEI W T S + H + H T+ I
Sbjct: 2543 GAAFQLHCVALGVPKPEITWEMPDHSLLSTAS---------KERTHGSEQLHLQGTLVIQ 2593
Query: 97 TLVEEDTGTYECRASN 112
D+G Y+C A N
Sbjct: 2594 NPQTSDSGIYKCTAKN 2609
Score = 40.4 bits (93), Expect = 0.003
Identities = 25/84 (29%), Positives = 33/84 (39%), Gaps = 12/84 (14%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G S+ LHC + G P P I+W G +DR I+ Y H T+ I
Sbjct: 2447 GESLSLHCVSDGIPKPNIKWTMPS------------GYVVDRPQINGKYILHDNGTLVIK 2494
Query: 97 TLVEEDTGTYECRASNDPDRNHLT 120
D G Y C+A N +T
Sbjct: 2495 EATAYDRGNYICKAQNSVGHTLIT 2518
Score = 38.1 bits (87), Expect = 0.013
Identities = 70/303 (23%), Positives = 108/303 (35%), Gaps = 48/303 (15%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G +VEL C A G P P + W Q SQ G+R V + T H S
Sbjct: 1760 GSTVELKCRAEGRPSPTVTWILANQTVVSESSQ---GSRQAVVTVDGTLVLHNLSIY--- 1813
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLT 156
D G Y+C ASN ++ L +++ + A V+L + T G + L
Sbjct: 1814 -----DRGFYKCVASNPGGQDSL--LVKIQVIAAPPVILEQRRQVIVGT---WGESLKLP 1863
Query: 157 CSLNDSATEVTGHRW-LKGGVVLKEDALPGQKTEF---------KVDSDDQWGEYSCVFL 206
C+ T W L G +K K + S D+ G Y C+
Sbjct: 1864 CTA--KGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDR-GTYECIAT 1920
Query: 207 PEP-------MGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVP-PVTDWAW--Y 256
M T ++ P A + +N G+ +L C + P P W
Sbjct: 1921 SSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSK 1980
Query: 257 KITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITL 316
+ D + + GS + + S L I ++ E D G Y C + G D ++ +
Sbjct: 1981 AVVDQQHRV---GSWIHVYPNGS-----LFIGSVT-EKDSGVYLCVARNKMGDDLILMHV 2031
Query: 317 RVR 319
+R
Sbjct: 2032 SLR 2034
Score = 35.8 bits (81), Expect = 0.067
Identities = 67/298 (22%), Positives = 107/298 (35%), Gaps = 41/298 (13%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
+G S L+C G+P PEI W PN G R Y + + I
Sbjct: 2351 LGKSTALNCSVDGNPPPEIIWIL----PN--------GTRFSNGPQSYQYLIASNGSFII 2398
Query: 96 DTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILL 155
ED G Y C A N ++ + ++ + + V+L PGTV G + L
Sbjct: 2399 SKTTREDAGKYRCAARNKV--GYIEKLVILE-IGQKPVILTYAPGTVKGIS---GESLSL 2452
Query: 156 TCSLNDSATEVTGHRWLKGGVVLKEDALPGQ-------KTEFKVDSDDQWGEYSCVF--- 205
C ++D + + G V+ + G+ K + G Y C
Sbjct: 2453 HC-VSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNS 2511
Query: 206 LPEPMGTANIQLHG-PPRVKAVKSSEHINE-GETAMLVCKSESVP-PVTDWAW--YKITD 260
+ + T + + PPR+ + G L C + VP P W + +
Sbjct: 2512 VGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLS 2571
Query: 261 SEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRV 318
+ K +GSE + L I+N +D G Y+C + GSD A ++V
Sbjct: 2572 TASKERTHGSEQLHL------QGTLVIQN-PQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
Score = 34.7 bits (78), Expect = 0.15
Identities = 28/97 (28%), Positives = 39/97 (40%), Gaps = 12/97 (12%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G ++ C+A GSPVPEI W + Q D H Y T+ +
Sbjct: 2053 GKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSG-----HRTRRYTLFNNGTLYFN 2107
Query: 97 TLVEEDTGTYECRASN----DPDRNHL---TRAPRVK 126
+ + G Y C A N D + HL T APR++
Sbjct: 2108 KVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIR 2144
Score = 34.3 bits (77), Expect = 0.19
Identities = 23/87 (26%), Positives = 36/87 (41%), Gaps = 14/87 (16%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHI--HATYHQHAASTI 93
VGG+V L+C G P P + W L DG+++ ++ + +
Sbjct: 489 VGGTVGLNCPGQGDPTPHVDW------------LLADGSKVRAPYVSEDGRILIDKSGKL 536
Query: 94 SIDTLVEEDTGTYECRASNDPDRNHLT 120
+ DTG Y C +SN D + LT
Sbjct: 537 ELQMADSFDTGVYHCISSNYDDADILT 563
Score = 32.0 bits (71), Expect = 0.96
Identities = 24/76 (31%), Positives = 33/76 (43%), Gaps = 14/76 (18%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G + L CE G P P+I W ND S +DR Y HA +++I+
Sbjct: 2156 GDTAVLDCEVTGDPKPKIFWLLPS---NDMIS-----FSIDR------YTFHANGSLTIN 2201
Query: 97 TLVEEDTGTYECRASN 112
+ D+G Y C A N
Sbjct: 2202 KVKLLDSGEYVCVARN 2217
>gi|33519481 neural cell adhesion molecule 2 precursor [Homo
sapiens]
Length = 837
Score = 56.2 bits (134), Expect = 5e-08
Identities = 64/295 (21%), Positives = 112/295 (37%), Gaps = 39/295 (13%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G E+ C SP P + W + N+ + + D + A + + I
Sbjct: 129 GEDAEVVCRVSSSPAPAVSWLYH----NEEVTTISDN----------RFAMLANNNLQIL 174
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLT 156
+ + D G Y C + R + + V + + P F + G ++ +
Sbjct: 175 NINKSDEGIYRCEGRVEA-RGEIDFRDIIVIVNVPPAISM--PQKSFNATAERGEEMTFS 231
Query: 157 CSLNDSATEVTGHRWLKGGVVLKED---ALPGQKTEFKVDS--DDQWGEYSCVF---LPE 208
C + S W + G +++E+ L G TE V + + G Y C E
Sbjct: 232 CRASGSPEPAIS--WFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGE 289
Query: 209 PMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITD-----SED 263
A +Q+ P + +K+ G+ LVC +E P+ + W + D D
Sbjct: 290 DEKQAFLQVFVQPHIIQLKNETTYENGQVT-LVCDAEG-EPIPEITWKRAVDGFTFTEGD 347
Query: 264 KALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRV 318
K+L + R V G S LHI+++ + +D G+Y C S G Q + L +
Sbjct: 348 KSL----DGRIEVKGQHGSSSLHIKDVKL-SDSGRYDCEAASRIGGHQKSMYLDI 397
Score = 42.4 bits (98), Expect = 7e-04
Identities = 44/192 (22%), Positives = 79/192 (41%), Gaps = 28/192 (14%)
Query: 25 FVQAPLSQQR----WVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVH 80
FVQ + Q + + G V L C+A G P+PEI W G T D + R+
Sbjct: 299 FVQPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEG---DKSLDGRIE 355
Query: 81 IHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPG 140
+ QH +S++ I + D+G Y+C A+ + + + ++ + +
Sbjct: 356 VKG---QHGSSSLHIKDVKLSDSGRYDCEAA-----SRIGGHQKSMYLDIEYAPKFISNQ 407
Query: 141 TVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKT---------EFK 191
T++ + E G+ I ++C + + W + +VL KT E
Sbjct: 408 TIYYSWE--GNPINISCDVKSNPP--ASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIA 463
Query: 192 VDSDDQWGEYSC 203
SD+ +G Y+C
Sbjct: 464 PTSDNDFGRYNC 475
Score = 38.9 bits (89), Expect = 0.008
Identities = 59/288 (20%), Positives = 105/288 (36%), Gaps = 44/288 (15%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G + C A GSP P I W+ G+ + + G+ + +++
Sbjct: 225 GEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTE---------------LTVR 269
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLT 156
++ D G Y CRA+N + +V +V+ + L E TT E+ G L+
Sbjct: 270 NIINSDGGPYVCRATNKAGEDEKQAFLQV-FVQPHIIQLKNE-----TTYEN-GQVTLVC 322
Query: 157 CSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFK------------VDSDDQWGEYSCV 204
+ + E+T R + G + D + E K V D G Y C
Sbjct: 323 DAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDS-GRYDCE 381
Query: 205 FLPEPMG---TANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDS 261
G + + + P+ + ++ + EG + C +S PP + I
Sbjct: 382 AASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPAS------IHWR 435
Query: 262 EDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGS 309
DK ++ + + S GR + + D G+Y C T+ G+
Sbjct: 436 RDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGT 483
Score = 38.5 bits (88), Expect = 0.010
Identities = 30/96 (31%), Positives = 40/96 (41%), Gaps = 9/96 (9%)
Query: 228 SSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHI 287
S ++ GE+ C + P DW +K + S R V RS L I
Sbjct: 28 SKVELSVGESKFFTCTAIGEPESIDW----YNPQGEKII---STQRVVVQKEGVRSRLTI 80
Query: 288 ENLNMEADPGQYRCNGTSSKGSDQ-AIITLRVRSHL 322
N N+E D G YRC T +KG Q A + L + L
Sbjct: 81 YNANIE-DAGIYRCQATDAKGQTQEATVVLEIYQKL 115
Score = 38.1 bits (87), Expect = 0.013
Identities = 32/133 (24%), Positives = 64/133 (48%), Gaps = 16/133 (12%)
Query: 176 VVLKEDALPGQKTEFKVDSDDQWGEYSCVFLPEP----MGTANIQLHGPPRVKAVKSSEH 231
VV++++ + + T + + +D G Y C T ++++ + V S +
Sbjct: 67 VVVQKEGVRSRLTIYNANIEDA-GIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQE 125
Query: 232 INEGETAMLVCKSESVP-PVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENL 290
+GE A +VC+ S P P W ++ ++ + S++RF + ++ + L I N+
Sbjct: 126 FKQGEDAEVVCRVSSSPAPAVSWLYH------NEEVTTISDNRFAMLAN---NNLQILNI 176
Query: 291 NMEADPGQYRCNG 303
N ++D G YRC G
Sbjct: 177 N-KSDEGIYRCEG 188
>gi|142976733 surface glycoprotein, Ig superfamily member [Homo
sapiens]
Length = 1264
Score = 55.8 bits (133), Expect = 6e-08
Identities = 72/309 (23%), Positives = 117/309 (37%), Gaps = 60/309 (19%)
Query: 40 VELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLV 99
V L C G P P++ W +GQ + G+ R++ H ++ D++
Sbjct: 239 VTLECVVSGVPAPQVYWLKDGQ-------DIAPGSNWRRLYSH----------LATDSVD 281
Query: 100 EEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVED----LGSKILL 155
D+G Y C A N ++ VK+V +V VLE ++ ++D LG+ +
Sbjct: 282 PADSGNYSCMAGN--------KSGDVKYV--TYMVNVLEHASISKGLQDQIVSLGATVHF 331
Query: 156 TCSLNDSATEVTGHRWLKGGVVLKEDA---LPGQKTEFKVDSDDQWGEYSCVF-----LP 207
TC ++ W + A G + + + G Y CV
Sbjct: 332 TCDVH--GNPAPNCTWFHNAQPIHPSARHLTAGNGLKISGVTVEDVGMYQCVADNGIGFM 389
Query: 208 EPMGTANIQLHG--PPRVKAVKSSEHINEGETAMLVCKSESVP-PVTDW--AWYKITDSE 262
G I+ G P + S + +G+ L C + +P PV W + IT
Sbjct: 390 HSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGLITSHP 449
Query: 263 DKALMNGS-------------ESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGS 309
+ L + S E +FV S G S LHI+ + E G+Y C + G+
Sbjct: 450 SQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQE-HAGKYICEAANEHGT 508
Query: 310 DQAIITLRV 318
QA +L V
Sbjct: 509 TQAEASLMV 517
Score = 41.6 bits (96), Expect = 0.001
Identities = 30/99 (30%), Positives = 46/99 (46%), Gaps = 12/99 (12%)
Query: 26 VQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQG-----PNDTC------SQLWDGA 74
+ AP+S + G V L C A G PVP I+ W++ G P+ SQL
Sbjct: 408 ITAPVSAKVADGDFVTLSCNASGLPVPVIR-WYDSHGLITSHPSQVLRSKSRKSQLSRPE 466
Query: 75 RLDRVHIHATYHQHAASTISIDTLVEEDTGTYECRASND 113
L+ ++ Q AS++ I + +E G Y C A+N+
Sbjct: 467 GLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANE 505
Score = 36.2 bits (82), Expect = 0.051
Identities = 50/246 (20%), Positives = 92/246 (37%), Gaps = 31/246 (12%)
Query: 36 VGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISI 95
+G +V C+ G+P P W+ Q +H A H A + + I
Sbjct: 325 LGATVHFTCDVHGNPAPNCTWFHNAQ----------------PIHPSAR-HLTAGNGLKI 367
Query: 96 DTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILL 155
+ ED G Y+C A N H T ++ V++ P V V D G + L
Sbjct: 368 SGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAP--VSAKVAD-GDFVTL 424
Query: 156 TCSLNDSATEVTGHRWLKG-GVVLK--EDALPGQKTEFKVDSDDQWGEYSCVFLPEPMGT 212
+C N S V RW G++ L + + ++ + F+ G
Sbjct: 425 SC--NASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGA 482
Query: 213 ANIQLHGPPRVKAVK-----SSEH-INEGETAMLVCKSESVPPVTDWAWYKITDSEDKAL 266
+++ + + A K ++EH + E +++V E+ ++D++
Sbjct: 483 SSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVVPFETNTKAETVTLPDAAQNDDRSK 542
Query: 267 MNGSES 272
+GSE+
Sbjct: 543 RDGSET 548
Score = 34.3 bits (77), Expect = 0.19
Identities = 30/89 (33%), Positives = 38/89 (42%), Gaps = 19/89 (21%)
Query: 25 FVQAPLSQQRWVGGSVELHCEAVGSPV-PEIQWWFEGQGPNDTCSQLWDGARLDRVHIHA 83
F PLS + +GG V LHC A PV I W L +G LD H
Sbjct: 31 FTSEPLSAVQKLGGPVVLHCSA--QPVTTRISW-------------LHNGKTLDGNLEHV 75
Query: 84 TYHQHAASTISIDTLVEEDTGTYECRASN 112
HQ T++I +L G Y+C A+N
Sbjct: 76 KIHQ---GTLTILSLNSSLLGYYQCLANN 101
>gi|239787787 kin of IRRE like 3 isoform 2 [Homo sapiens]
Length = 600
Score = 54.7 bits (130), Expect = 1e-07
Identities = 77/316 (24%), Positives = 128/316 (40%), Gaps = 57/316 (18%)
Query: 40 VELHCEAVGSP-VPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTL 98
V HC A +P V + +W GQ + +++ R + TY S
Sbjct: 267 VTFHCSAKANPAVTQYRWAKRGQIIKEASGEVY------RTTVDYTYFSEPVS------- 313
Query: 99 VEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCS 158
C +N +L+R V + + EP ++ DLGS + +C+
Sbjct: 314 ---------CEVTNALGSTNLSRTVDVYF----GPRMTTEPQSLLV---DLGSDAIFSCA 357
Query: 159 L--NDSATEVTGHRWLK--GGVVLKEDALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTAN 214
N S T V W+K GVVL + K+ + D+ G+Y C + +G
Sbjct: 358 WTGNPSLTIV----WMKRGSGVVLSNEKTLTLKSVRQEDA----GKYVCRAVVPRVGAGE 409
Query: 215 ----IQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGS 270
+ ++GPP + + ++ +H GE + C S PP AW ++ L +G+
Sbjct: 410 REVTLTVNGPPIISSTQT-QHALHGEKGQIKCFIRSTPPPDRIAW----SWKENVLESGT 464
Query: 271 ESRFFV---SSSQG-RSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSHLAALW 326
R+ V S+ +G S L I N+ Y C +S GSD II R++ + +
Sbjct: 465 SGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEII--RLKEQGSEMK 522
Query: 327 PFLGIVAEVLVLVTII 342
G+ AE + + II
Sbjct: 523 SGAGLEAESVPMAVII 538
>gi|26006461 kin of IRRE like 3 isoform 1 [Homo sapiens]
Length = 778
Score = 54.7 bits (130), Expect = 1e-07
Identities = 77/316 (24%), Positives = 128/316 (40%), Gaps = 57/316 (18%)
Query: 40 VELHCEAVGSP-VPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTL 98
V HC A +P V + +W GQ + +++ R + TY S
Sbjct: 267 VTFHCSAKANPAVTQYRWAKRGQIIKEASGEVY------RTTVDYTYFSEPVS------- 313
Query: 99 VEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCS 158
C +N +L+R V + + EP ++ DLGS + +C+
Sbjct: 314 ---------CEVTNALGSTNLSRTVDVYF----GPRMTTEPQSLLV---DLGSDAIFSCA 357
Query: 159 L--NDSATEVTGHRWLK--GGVVLKEDALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTAN 214
N S T V W+K GVVL + K+ + D+ G+Y C + +G
Sbjct: 358 WTGNPSLTIV----WMKRGSGVVLSNEKTLTLKSVRQEDA----GKYVCRAVVPRVGAGE 409
Query: 215 ----IQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGS 270
+ ++GPP + + ++ +H GE + C S PP AW ++ L +G+
Sbjct: 410 REVTLTVNGPPIISSTQT-QHALHGEKGQIKCFIRSTPPPDRIAW----SWKENVLESGT 464
Query: 271 ESRFFV---SSSQG-RSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSHLAALW 326
R+ V S+ +G S L I N+ Y C +S GSD II R++ + +
Sbjct: 465 SGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEII--RLKEQGSEMK 522
Query: 327 PFLGIVAEVLVLVTII 342
G+ AE + + II
Sbjct: 523 SGAGLEAESVPMAVII 538
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 54.3 bits (129), Expect = 2e-07
Identities = 78/317 (24%), Positives = 118/317 (37%), Gaps = 58/317 (18%)
Query: 18 GASGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLD 77
G+ FV P + + VG SV L C A G P P I W + P
Sbjct: 337 GSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTP-------------- 382
Query: 78 RVHIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVL 137
+ + + + + I +V+ D+G Y C A+N+ D H T A +V L
Sbjct: 383 -LPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHAT---------AFIIVQAL 432
Query: 138 EPGTVFTTVEDLGSKILLTCSLNDSATEVTGH-----RWLKGGVVLKED-----ALPGQK 187
TV T +D ++++ D E G+ W KGG L D G
Sbjct: 433 PQFTV--TPQD---RVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTL 487
Query: 188 TEFKVDSDDQWGEYSC-----VFLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVC 242
V DQ G+Y C + + + +Q P ++ S + G L C
Sbjct: 488 RISGVALHDQ-GQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPC 546
Query: 243 KSESVP-PVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRC 301
S+ P P W +K + +ES F S +G L I ++ AD G+Y C
Sbjct: 547 SSQGEPEPAITW---------NKDGVQVTESGKFHISPEG--FLTINDVG-PADAGRYEC 594
Query: 302 NGTSSKGSDQAIITLRV 318
++ GS + L V
Sbjct: 595 VARNTIGSASVSMVLSV 611
Score = 47.8 bits (112), Expect = 2e-05
Identities = 79/354 (22%), Positives = 124/354 (35%), Gaps = 50/354 (14%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G +V C A G+P PEI W N+ S D +RL+ + T+ I
Sbjct: 260 GNTVYFTCRAEGNPKPEIIWLRN----NNELSMKTD-SRLNLLD---------DGTLMIQ 305
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLT 156
E D G Y+C A N + V++P V G + L
Sbjct: 306 NTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLV---GESVTLE 362
Query: 157 CSLNDSATEVTGH-----RWLKGG-----VVLKEDALPGQKTEFKVDSDDQWGEYSCVF- 205
CS TGH W +G V + + P + GEY+C
Sbjct: 363 CS-------ATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSAT 415
Query: 206 --LPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSE-SVPPVTDWAWYKITDSE 262
+ TA I + P+ + EG+T C+++ + PPV W S
Sbjct: 416 NNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSV 475
Query: 263 DKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSHL 322
D+ R V SS L I + + D GQY C + GS + + L V+ +
Sbjct: 476 DR--------RHLVLSS---GTLRISGVALH-DQGQYECQAVNIIGSQKVVAHLTVQPRV 523
Query: 323 AALWPFLGIVAEVLVLVTIIFIYEKRRKPEDVLDDDDAGSAPLKSSGQHQNDKG 376
++ + V V + + +PE + + G +S H + +G
Sbjct: 524 TPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEG 577
>gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo
sapiens]
Length = 790
Score = 53.5 bits (127), Expect = 3e-07
Identities = 63/239 (26%), Positives = 92/239 (38%), Gaps = 29/239 (12%)
Query: 87 QHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTV 146
Q A ++ I ++ D G Y+C ASN N +TRA VR V + F+
Sbjct: 565 QLADLSLEISGIIPTDGGRYQCVASN---ANGVTRASVWLLVREAPQVSIHTSSQHFSQ- 620
Query: 147 EDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDA---LPGQKTEF-KVDSDDQWGEYS 202
G ++ ++CS + T W + L+ED+ + Q T + + + G YS
Sbjct: 621 ---GVEVKVSCSASGYPTPHIS--WSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYS 675
Query: 203 CVFLPE---PMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKIT 259
C E T + PP V AV + + GE A+LVC++ VPP WY+
Sbjct: 676 CQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPP-PRVIWYR-- 732
Query: 260 DSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRV 318
G +L I E D G Y C + G A I L V
Sbjct: 733 ---------GGLEMILAPEGSSSGKLRIP-AAQERDAGTYTCRAVNELGDASAEIQLAV 781
Score = 45.8 bits (107), Expect = 6e-05
Identities = 49/197 (24%), Positives = 76/197 (38%), Gaps = 44/197 (22%)
Query: 31 SQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAA 90
SQ G V++ C A G P P I W E Q + R+H+ A
Sbjct: 615 SQHFSQGVEVKVSCSASGYPTPHISWSRESQALQED----------SRIHVDAQ------ 658
Query: 91 STISIDTLVEEDTGTYECRASNDPDRN------HLTRAPRVKWVRAQAVVLVLEPGTVFT 144
T+ I + ED G Y C+A+N+ + + T P V V A +V V
Sbjct: 659 GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAV-------- 710
Query: 145 TVEDLGSKILLTCSLNDSATEVTGHR--WLKGG--VVLKEDALPGQKTEFKVDSDDQWGE 200
G + +L C A+ V R W +GG ++L + K + G
Sbjct: 711 -----GEEAVLVC----EASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGT 761
Query: 201 YSCVFLPEPMGTANIQL 217
Y+C + E +G A+ ++
Sbjct: 762 YTCRAVNE-LGDASAEI 777
Score = 33.1 bits (74), Expect = 0.43
Identities = 37/153 (24%), Positives = 62/153 (40%), Gaps = 25/153 (16%)
Query: 181 DALPGQKTEFKVDSDDQW----------GEYSCVFLPEPMGT----ANIQLHGPPRVKAV 226
+A G++ F+ + W G Y C + GT A I + PP
Sbjct: 463 EARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRA-GTGRAKAQIVVTDPPPQLVP 521
Query: 227 KSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELH 286
+ ++ GETA+L C+ V A Y +T D ++ S R + L
Sbjct: 522 APNVTVSPGETAVLSCR------VLGEAPYNLTWVRDWRVLPASTGRV---AQLADLSLE 572
Query: 287 IENLNMEADPGQYRCNGTSSKGSDQAIITLRVR 319
I + + D G+Y+C +++ G +A + L VR
Sbjct: 573 ISGI-IPTDGGRYQCVASNANGVTRASVWLLVR 604
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 52.0 bits (123), Expect = 9e-07
Identities = 69/290 (23%), Positives = 111/290 (38%), Gaps = 38/290 (13%)
Query: 40 VELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLV 99
V++ C+A G P P I W+ + A + V + Q + I LV
Sbjct: 326 VDIPCQAKGVPPPSITWYKD--------------AAVVEVEKLTRFRQRNDGGLQISGLV 371
Query: 100 EEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCSL 159
+DTG ++C A RN ++ ++ + G + +TV D G ++L C
Sbjct: 372 PDDTGMFQCFA-----RNAAGEVQTSTYLAVTSIAPNITRGPLDSTVID-GMSVVLACET 425
Query: 160 N----DSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSD--DQWGEYSCVFLPE---PM 210
+ + T G R L G V P + + G Y+C+
Sbjct: 426 SGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDE 485
Query: 211 GTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVT-DWAWYKITDSEDKALMNG 269
+A++ + R+ + + +G A +VC P VT + W K D A + G
Sbjct: 486 ASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEK-----DGATL-G 539
Query: 270 SESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVR 319
+ES + + S LHI D G Y C S+ G+D LRVR
Sbjct: 540 TESHPRIRLDRNGS-LHISQ-TWSGDIGTYTCRVISAGGNDSRSAHLRVR 587
Score = 34.7 bits (78), Expect = 0.15
Identities = 59/247 (23%), Positives = 94/247 (38%), Gaps = 30/247 (12%)
Query: 91 STISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVR-------AQAVVLVLEPGTVF 143
+T+ I + V D G Y +A ND + ++ T P V A +++ P
Sbjct: 166 NTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKN-- 223
Query: 144 TTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALP-GQKTEFKVDSDDQWGEYS 202
T+V S++ L C N W K GV+L ++ + G Y
Sbjct: 224 TSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYE 283
Query: 203 C------VFLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLV---CKSESVPPVTDW 253
C +P + A + + PP+ VK E E +V C+++ VPP
Sbjct: 284 CEAVLRSSSVPSVVRGAYLSVLEPPQF--VKEPERHITAEMEKVVDIPCQAKGVPP-PSI 340
Query: 254 AWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAI 313
WYK D A++ + F + G L I L + D G ++C ++ G Q
Sbjct: 341 TWYK-----DAAVVEVEKLTRFRQRNDG--GLQISGL-VPDDTGMFQCFARNAAGEVQTS 392
Query: 314 ITLRVRS 320
L V S
Sbjct: 393 TYLAVTS 399
Score = 29.6 bits (65), Expect = 4.8
Identities = 57/251 (22%), Positives = 87/251 (34%), Gaps = 52/251 (20%)
Query: 93 ISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVE----- 147
++I D G YEC A + R+ V V A + VLEP E
Sbjct: 269 LTIPNPTGSDAGYYECEA--------VLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITA 320
Query: 148 DLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSD----------DQ 197
++ + + C W K V++ + L T F+ +D D
Sbjct: 321 EMEKVVDIPCQAK--GVPPPSITWYKDAAVVEVEKL----TRFRQRNDGGLQISGLVPDD 374
Query: 198 WGEYSCVFLPEPMGTANIQLHGP-----PRVKAVKSSEHINEGETAMLVCKSESVP-PVT 251
G + C F G + P + + +G + +L C++ P P
Sbjct: 375 TGMFQC-FARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAI 433
Query: 252 DWAWYKITDSEDKALMNGSES--RF--FVSSSQGRSELHIENLNMEADPGQYRCNGTSSK 307
W ++ L +GS RF S S S HI +D G Y C T+S+
Sbjct: 434 TW------QKGERILASGSVQLPRFTPLESGSLLISPTHI------SDAGTYTCLATNSR 481
Query: 308 GSDQAIITLRV 318
G D+A L V
Sbjct: 482 GVDEASADLVV 492
>gi|4827022 contactin 2 precursor [Homo sapiens]
Length = 1040
Score = 52.0 bits (123), Expect = 9e-07
Identities = 80/302 (26%), Positives = 117/302 (38%), Gaps = 52/302 (17%)
Query: 29 PLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQH 88
P VG V L C A G+PVP I+W + + + S W A
Sbjct: 246 PAETYALVGQQVTLECFAFGNPVPRIKW----RKVDGSLSPQWTTAE------------- 288
Query: 89 AASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVED 148
T+ I ++ ED GTYEC A N R+ T R+ V+AQ L + + T D
Sbjct: 289 --PTLQIPSVSFEDEGTYECEAENSKGRD--TVQGRI-IVQAQPEWLKV----ISDTEAD 339
Query: 149 LGSKILLTCSLNDSATEVTGHRWLKGGVVL----KEDALPGQKTEFKVDSDDQWGEYSCV 204
+GS + C+ RWL+ G L + + L G K+ +D G Y CV
Sbjct: 340 IGSNLRWGCAAAGKPRPTV--RWLRNGEPLASQNRVEVLAGDLRFSKLSLEDS-GMYQCV 396
Query: 205 FLPEPMGT------ANIQLHGPP-RVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYK 257
GT +Q P R+ V+ G ++ C+ + P W K
Sbjct: 397 -AENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAV-VLWSK 454
Query: 258 ITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLR 317
T+ L+N SR V+ L I N++ +D G+Y C + G + L
Sbjct: 455 GTE----ILVN--SSRVTVTPD---GTLIIRNIS-RSDEGKYTCFAENFMGKANSTGILS 504
Query: 318 VR 319
VR
Sbjct: 505 VR 506
>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
sapiens]
Length = 1248
Score = 50.8 bits (120), Expect = 2e-06
Identities = 49/175 (28%), Positives = 71/175 (40%), Gaps = 30/175 (17%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G + L C+A G+PVP +QW E D + L D + +A T+ I
Sbjct: 436 GSTAYLLCKAFGAPVPSVQWLDE-----DGTTVLQD----------ERFFPYANGTLGIR 480
Query: 97 TLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLT 156
L DTG Y C A+ND + + +VK A + P +T+E GS++ T
Sbjct: 481 DLQANDTGRYFCLAANDQNNVTIMANLKVK----DATQITQGPR---STIEKKGSRVTFT 533
Query: 157 CSLNDSATEVTGHRWLKGGVVLKE-------DALPGQKTEFKVDSDDQWGEYSCV 204
C + + W G L+E G+ +D DQ G YSCV
Sbjct: 534 CQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQ-GNYSCV 587
Score = 33.1 bits (74), Expect = 0.43
Identities = 26/76 (34%), Positives = 31/76 (40%), Gaps = 16/76 (21%)
Query: 37 GGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISID 96
G + L C A G P P I+W GP DRV TY H T+ +
Sbjct: 252 GQPLVLECIAEGFPTPTIKW-LRPSGPMPA----------DRV----TYQNHN-KTLQLL 295
Query: 97 TLVEEDTGTYECRASN 112
+ EED G Y C A N
Sbjct: 296 KVGEEDDGEYRCLAEN 311
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,045,483
Number of Sequences: 37866
Number of extensions: 746473
Number of successful extensions: 3983
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 123
Number of HSP's successfully gapped in prelim test: 191
Number of HSP's that attempted gapping in prelim test: 2110
Number of HSP's gapped (non-prelim): 1393
length of query: 385
length of database: 18,247,518
effective HSP length: 104
effective length of query: 281
effective length of database: 14,309,454
effective search space: 4020956574
effective search space used: 4020956574
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.