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Search of human proteins with 38348280
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38348280 SH2 domain containing 6 [Homo sapiens]
(175 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38348280 SH2 domain containing 6 [Homo sapiens] 368 e-102
gi|166235901 B-cell linker isoform 2 [Homo sapiens] 104 4e-23
gi|7019535 B-cell linker isoform 1 [Homo sapiens] 104 4e-23
gi|5031855 lymphocyte cytosolic protein 2 [Homo sapiens] 73 1e-13
gi|193083221 mast cell immunoreceptor signal transducer [Homo sa... 70 9e-13
gi|4503787 fyn-related kinase [Homo sapiens] 46 2e-05
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 45 2e-05
gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit... 44 9e-05
gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [... 40 0.001
gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2 ... 40 0.001
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ... 40 0.001
gi|224926824 SH2B adaptor protein 1 isoform 2 [Homo sapiens] 40 0.001
gi|224926830 SH2B adaptor protein 1 isoform 3 [Homo sapiens] 40 0.001
gi|224926828 SH2B adaptor protein 1 isoform 2 [Homo sapiens] 40 0.001
gi|224926826 SH2B adaptor protein 1 isoform 1 [Homo sapiens] 40 0.001
gi|224926822 SH2B adaptor protein 1 isoform 2 [Homo sapiens] 40 0.001
gi|224586793 src homology 2 domain-containing transforming prote... 39 0.002
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa... 39 0.002
gi|222537752 Src homology 2 domain containing transforming prote... 37 0.007
gi|208609985 SH2 domain containing 3A [Homo sapiens] 37 0.007
gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo ... 37 0.011
gi|169790811 SHC (Src homology 2 domain containing) transforming... 37 0.011
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ... 37 0.011
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [... 37 0.011
gi|157168329 formin 1 [Homo sapiens] 36 0.015
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] 36 0.015
gi|128485756 hexaribonucleotide binding protein 3 [Homo sapiens] 36 0.015
gi|91208437 GEM interacting protein [Homo sapiens] 36 0.015
gi|150378503 leiomodin 2 (cardiac) [Homo sapiens] 35 0.033
gi|38683860 insulin receptor substrate 2 [Homo sapiens] 35 0.043
>gi|38348280 SH2 domain containing 6 [Homo sapiens]
Length = 175
Score = 368 bits (944), Expect = e-102
Identities = 175/175 (100%), Positives = 175/175 (100%)
Query: 1 MYASSYPPPPQLSPRSHLCPPPPHPTPPQLNNLLLLEGRKSSLPSVAPTGSASAAEDSDL 60
MYASSYPPPPQLSPRSHLCPPPPHPTPPQLNNLLLLEGRKSSLPSVAPTGSASAAEDSDL
Sbjct: 1 MYASSYPPPPQLSPRSHLCPPPPHPTPPQLNNLLLLEGRKSSLPSVAPTGSASAAEDSDL 60
Query: 61 LTQPWYSGNCDRYAVESALLHLQKDGAYTVRPSSGPHGSQPFTLAVLLRGRVFNIPIRRL 120
LTQPWYSGNCDRYAVESALLHLQKDGAYTVRPSSGPHGSQPFTLAVLLRGRVFNIPIRRL
Sbjct: 61 LTQPWYSGNCDRYAVESALLHLQKDGAYTVRPSSGPHGSQPFTLAVLLRGRVFNIPIRRL 120
Query: 121 DGGRHYALGREGRNREELFSSVAAMVQHFMWHPLPLVDRHSGSRELTCLLFPTKP 175
DGGRHYALGREGRNREELFSSVAAMVQHFMWHPLPLVDRHSGSRELTCLLFPTKP
Sbjct: 121 DGGRHYALGREGRNREELFSSVAAMVQHFMWHPLPLVDRHSGSRELTCLLFPTKP 175
>gi|166235901 B-cell linker isoform 2 [Homo sapiens]
Length = 433
Score = 104 bits (259), Expect = 4e-23
Identities = 52/132 (39%), Positives = 83/132 (62%), Gaps = 2/132 (1%)
Query: 43 LPSVAPTGSASAAEDSDLLTQPWYSGNCDRYAVESALLHLQKDGAYTVRPSSGPHGSQPF 102
LPS + + S + +++ +L +PWY+G CDR + E AL KDG++ +R SSG QP+
Sbjct: 302 LPSFS-SNSTISEQEAGVLCKPWYAGACDRKSAEEALHRSNKDGSFLIRKSSGHDSKQPY 360
Query: 103 TLAVLLRGRVFNIPIRRLDGGRHYALGREGRNREELFSSVAAMVQHFMWHPLPLVDRHSG 162
TL V RV+NIP+R ++ + YALGR+ +N EE F SVA ++++ PL L+D +
Sbjct: 361 TLVVFFNKRVYNIPVRFIEATKQYALGRK-KNGEEYFGSVAEIIRNHQHSPLVLIDSQNN 419
Query: 163 SRELTCLLFPTK 174
+++ T L + K
Sbjct: 420 TKDSTRLKYAVK 431
>gi|7019535 B-cell linker isoform 1 [Homo sapiens]
Length = 456
Score = 104 bits (259), Expect = 4e-23
Identities = 52/132 (39%), Positives = 83/132 (62%), Gaps = 2/132 (1%)
Query: 43 LPSVAPTGSASAAEDSDLLTQPWYSGNCDRYAVESALLHLQKDGAYTVRPSSGPHGSQPF 102
LPS + + S + +++ +L +PWY+G CDR + E AL KDG++ +R SSG QP+
Sbjct: 325 LPSFS-SNSTISEQEAGVLCKPWYAGACDRKSAEEALHRSNKDGSFLIRKSSGHDSKQPY 383
Query: 103 TLAVLLRGRVFNIPIRRLDGGRHYALGREGRNREELFSSVAAMVQHFMWHPLPLVDRHSG 162
TL V RV+NIP+R ++ + YALGR+ +N EE F SVA ++++ PL L+D +
Sbjct: 384 TLVVFFNKRVYNIPVRFIEATKQYALGRK-KNGEEYFGSVAEIIRNHQHSPLVLIDSQNN 442
Query: 163 SRELTCLLFPTK 174
+++ T L + K
Sbjct: 443 TKDSTRLKYAVK 454
>gi|5031855 lymphocyte cytosolic protein 2 [Homo sapiens]
Length = 533
Score = 73.2 bits (178), Expect = 1e-13
Identities = 49/145 (33%), Positives = 72/145 (49%), Gaps = 2/145 (1%)
Query: 21 PPPHPTPPQLNNLLLLEGRKSSLPSVAPTGSASAAEDSDLLTQPWYSGNCDRYAVESALL 80
PP P + EGR LP S AE+ + L + WY R E+AL
Sbjct: 378 PPYFSQGPSNRPPIRAEGRNFPLPLPNKPRPPSPAEEENSLNEEWYVSYITRPEAEAALR 437
Query: 81 HLQKDGAYTVRPSSGPHGSQPFTLAVLLRGRVFNIPIRRLDGGRHYALGREGRNREELFS 140
+ +DG + VR SS + P+ L VL + +V+NI IR + Y LG R +E+ F
Sbjct: 438 KINQDGTFLVRDSSKKTTTNPYVLMVLYKDKVYNIQIRYQKESQVYLLGTGLRGKED-FL 496
Query: 141 SVAAMVQHFMWHPLPLVD-RHSGSR 164
SV+ ++ +F PL L+D ++ GSR
Sbjct: 497 SVSDIIDYFRKMPLLLIDGKNRGSR 521
>gi|193083221 mast cell immunoreceptor signal transducer [Homo
sapiens]
Length = 428
Score = 70.1 bits (170), Expect = 9e-13
Identities = 36/104 (34%), Positives = 57/104 (54%), Gaps = 1/104 (0%)
Query: 55 AEDSDLLTQPWYSGNCDRYAVESALLHLQKDGAYTVRPSSGPHGSQPFTLAVLLRGRVFN 114
++ D+ WY G R AVE A + KDG++ VR S +P+ LAV +V+N
Sbjct: 299 SDRKDVQHNEWYIGEYSRQAVEEAFMKENKDGSFLVRDCSTKSKEEPYVLAVFYENKVYN 358
Query: 115 IPIRRLDGGRHYALGREGRNREELFSSVAAMVQHFMWHPLPLVD 158
+ IR L+ + +ALG G +E F SV +++H+ P+ L+D
Sbjct: 359 VKIRFLERNQQFALG-TGLRGDEKFDSVEDIIEHYKNFPIILID 401
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 45.8 bits (107), Expect = 2e-05
Identities = 35/114 (30%), Positives = 52/114 (45%), Gaps = 11/114 (9%)
Query: 37 EGRKSSLPSVAPTGSASAAEDSDLLTQPWYSGNCDRYAVESALLHLQ-KDGAYTVRPSSG 95
+G L P S AED L +PW+ G R E LL+ + K G++ +R S
Sbjct: 90 DGSSQQLQGYIP--SNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESES 147
Query: 96 PHGSQPFTLAVLLRGRVFNIPIRRLDGGRHYALGREGRNREELFSSVAAMVQHF 149
G F+L+VL V + I+RLD G + R +FS++ V H+
Sbjct: 148 QKGE--FSLSVLDGAVVKHYRIKRLDEGGFFL------TRRRIFSTLNEFVSHY 193
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 45.4 bits (106), Expect = 2e-05
Identities = 27/93 (29%), Positives = 44/93 (47%), Gaps = 10/93 (10%)
Query: 62 TQPWYSGNCDRYAVESALLHLQKDGAYTVRPSSGPHGSQPFTLAVLLRGRVFNIPIRRLD 121
++PWY + R E L+ + +DGA+ +R GS + + RG+V + I R
Sbjct: 643 SKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKR---EGSDSYAITFRARGKVKHCRINR-- 697
Query: 122 GGRHYALGREGRNREELFSSVAAMVQHFMWHPL 154
GRH+ LG F S+ +V ++ H L
Sbjct: 698 DGRHFVLGTSA-----YFESLVELVSYYEKHSL 725
>gi|158631203 dual adaptor of phosphotyrosine and
3-phosphoinositides [Homo sapiens]
Length = 280
Score = 43.5 bits (101), Expect = 9e-05
Identities = 37/123 (30%), Positives = 55/123 (44%), Gaps = 17/123 (13%)
Query: 35 LLEGRKSSLPSVAPTGSASAAEDSDLLTQPWYSGNCDRYAVESALLHLQKDGAYTVRPSS 94
LLEG K S + S S E L WY GN R+A E+ LL DG+Y +R S+
Sbjct: 6 LLEG-KMSTQDPSDLWSRSDGEAELLQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSN 64
Query: 95 GPHGSQPFTLAVLLRGRVFNIPIRRLDGGRHYALGREGRNRE---ELFSSVAAMVQHFMW 151
G ++++ +R D +H+ + G + + FSS+ V+HF
Sbjct: 65 ETTG-------------LYSLSVRAKDSVKHFHVEYTGYSFKFGFNEFSSLKDFVKHFAN 111
Query: 152 HPL 154
PL
Sbjct: 112 QPL 114
>gi|33356177 protein tyrosine phosphatase, non-receptor type 11
[Homo sapiens]
Length = 593
Score = 40.0 bits (92), Expect = 0.001
Identities = 32/107 (29%), Positives = 53/107 (49%), Gaps = 9/107 (8%)
Query: 60 LLTQPWYSGNCDRYAVESALLHLQKDGAYTVRPSSGPHGSQPFTLAVLLRGRVFNIPIRR 119
+ ++ W+ N E+ LL DG++ RPS G FTL+V G V +I I+
Sbjct: 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGD--FTLSVRRNGAVTHIKIQ- 57
Query: 120 LDGGRHYALGREGRNREELFSSVAAMVQHFMWHPLPLVDRHSGSREL 166
+ G +Y L E F+++A +VQ++M H L +++ EL
Sbjct: 58 -NTGDYYDL-----YGGEKFATLAELVQYYMEHHGQLKEKNGDVIEL 98
>gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 287
Score = 40.0 bits (92), Expect = 0.001
Identities = 38/141 (26%), Positives = 58/141 (41%), Gaps = 16/141 (11%)
Query: 35 LLEGRKSSLPSVAPTGSASAAEDSDLLTQPWYSGNCDRYAVESALLHLQKDGAYTVRPSS 94
L G PS A + D QPWY+G +R E+ L++ + + Y VR +
Sbjct: 82 LASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGAMERLQAETELIN-RVNSTYLVRHRT 140
Query: 95 GPHGSQPFTLAVLLRGRVFNIPIRRLDGGRHYALGREGRNREELFSSVAAMVQHFMWHPL 154
G + +++ +I I DG H A R+ F S+ +V+++ H L
Sbjct: 141 KESGE--YAISIKYNNEAKHIKILTRDGFFHIAENRK-------FKSLMELVEYYKHHSL 191
Query: 155 PLVDRHSGSREL-TCLLFPTK 174
G R L T L FP K
Sbjct: 192 -----KEGFRTLDTTLQFPYK 207
>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 847
Score = 40.0 bits (92), Expect = 0.001
Identities = 38/141 (26%), Positives = 58/141 (41%), Gaps = 16/141 (11%)
Query: 35 LLEGRKSSLPSVAPTGSASAAEDSDLLTQPWYSGNCDRYAVESALLHLQKDGAYTVRPSS 94
L G PS A + D QPWY+G +R E+ L++ + + Y VR +
Sbjct: 642 LASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGAMERLQAETELIN-RVNSTYLVRHRT 700
Query: 95 GPHGSQPFTLAVLLRGRVFNIPIRRLDGGRHYALGREGRNREELFSSVAAMVQHFMWHPL 154
G + +++ +I I DG H A R+ F S+ +V+++ H L
Sbjct: 701 KESGE--YAISIKYNNEAKHIKILTRDGFFHIAENRK-------FKSLMELVEYYKHHSL 751
Query: 155 PLVDRHSGSREL-TCLLFPTK 174
G R L T L FP K
Sbjct: 752 -----KEGFRTLDTTLQFPYK 767
>gi|224926824 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
Length = 671
Score = 39.7 bits (91), Expect = 0.001
Identities = 40/154 (25%), Positives = 58/154 (37%), Gaps = 28/154 (18%)
Query: 7 PPPPQLSPRSHLCPPPPHPTPPQLNNLLLLEGRKSSLPSVAPTGSASAAEDSDLLTQPWY 66
PP + P S P PP TP L +G P G D L PW+
Sbjct: 482 PPTGTVHPLS--APYPPLDTPETATGSFLFQGE--------PEGGEG---DQPLSGYPWF 528
Query: 67 SGNCDRYAVESALLH--LQKDGAYTVRPSSGPHGSQPFTLAVLLRGRVFNIPIRRLDGGR 124
G R +L G + VR S G + L +G+ ++ +
Sbjct: 529 HGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGE--YVLTFNFQGKAKHLRL------- 579
Query: 125 HYALGREGRNREE--LFSSVAAMVQHFMWHPLPL 156
+L EG+ R + F S+ M++HF HP+PL
Sbjct: 580 --SLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPL 611
>gi|224926830 SH2B adaptor protein 1 isoform 3 [Homo sapiens]
Length = 683
Score = 39.7 bits (91), Expect = 0.001
Identities = 40/154 (25%), Positives = 58/154 (37%), Gaps = 28/154 (18%)
Query: 7 PPPPQLSPRSHLCPPPPHPTPPQLNNLLLLEGRKSSLPSVAPTGSASAAEDSDLLTQPWY 66
PP + P S P PP TP L +G P G D L PW+
Sbjct: 482 PPTGTVHPLS--APYPPLDTPETATGSFLFQGE--------PEGGEG---DQPLSGYPWF 528
Query: 67 SGNCDRYAVESALLH--LQKDGAYTVRPSSGPHGSQPFTLAVLLRGRVFNIPIRRLDGGR 124
G R +L G + VR S G + L +G+ ++ +
Sbjct: 529 HGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGE--YVLTFNFQGKAKHLRL------- 579
Query: 125 HYALGREGRNREE--LFSSVAAMVQHFMWHPLPL 156
+L EG+ R + F S+ M++HF HP+PL
Sbjct: 580 --SLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPL 611
>gi|224926828 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
Length = 671
Score = 39.7 bits (91), Expect = 0.001
Identities = 40/154 (25%), Positives = 58/154 (37%), Gaps = 28/154 (18%)
Query: 7 PPPPQLSPRSHLCPPPPHPTPPQLNNLLLLEGRKSSLPSVAPTGSASAAEDSDLLTQPWY 66
PP + P S P PP TP L +G P G D L PW+
Sbjct: 482 PPTGTVHPLS--APYPPLDTPETATGSFLFQGE--------PEGGEG---DQPLSGYPWF 528
Query: 67 SGNCDRYAVESALLH--LQKDGAYTVRPSSGPHGSQPFTLAVLLRGRVFNIPIRRLDGGR 124
G R +L G + VR S G + L +G+ ++ +
Sbjct: 529 HGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGE--YVLTFNFQGKAKHLRL------- 579
Query: 125 HYALGREGRNREE--LFSSVAAMVQHFMWHPLPL 156
+L EG+ R + F S+ M++HF HP+PL
Sbjct: 580 --SLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPL 611
>gi|224926826 SH2B adaptor protein 1 isoform 1 [Homo sapiens]
Length = 756
Score = 39.7 bits (91), Expect = 0.001
Identities = 40/154 (25%), Positives = 58/154 (37%), Gaps = 28/154 (18%)
Query: 7 PPPPQLSPRSHLCPPPPHPTPPQLNNLLLLEGRKSSLPSVAPTGSASAAEDSDLLTQPWY 66
PP + P S P PP TP L +G P G D L PW+
Sbjct: 482 PPTGTVHPLS--APYPPLDTPETATGSFLFQGE--------PEGGEG---DQPLSGYPWF 528
Query: 67 SGNCDRYAVESALLH--LQKDGAYTVRPSSGPHGSQPFTLAVLLRGRVFNIPIRRLDGGR 124
G R +L G + VR S G + L +G+ ++ +
Sbjct: 529 HGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGE--YVLTFNFQGKAKHLRL------- 579
Query: 125 HYALGREGRNREE--LFSSVAAMVQHFMWHPLPL 156
+L EG+ R + F S+ M++HF HP+PL
Sbjct: 580 --SLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPL 611
>gi|224926822 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
Length = 671
Score = 39.7 bits (91), Expect = 0.001
Identities = 40/154 (25%), Positives = 58/154 (37%), Gaps = 28/154 (18%)
Query: 7 PPPPQLSPRSHLCPPPPHPTPPQLNNLLLLEGRKSSLPSVAPTGSASAAEDSDLLTQPWY 66
PP + P S P PP TP L +G P G D L PW+
Sbjct: 482 PPTGTVHPLS--APYPPLDTPETATGSFLFQGE--------PEGGEG---DQPLSGYPWF 528
Query: 67 SGNCDRYAVESALLH--LQKDGAYTVRPSSGPHGSQPFTLAVLLRGRVFNIPIRRLDGGR 124
G R +L G + VR S G + L +G+ ++ +
Sbjct: 529 HGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGE--YVLTFNFQGKAKHLRL------- 579
Query: 125 HYALGREGRNREE--LFSSVAAMVQHFMWHPLPL 156
+L EG+ R + F S+ M++HF HP+PL
Sbjct: 580 --SLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPL 611
>gi|224586793 src homology 2 domain-containing transforming protein
C3 [Homo sapiens]
Length = 594
Score = 39.3 bits (90), Expect = 0.002
Identities = 45/185 (24%), Positives = 76/185 (41%), Gaps = 29/185 (15%)
Query: 2 YASSYPPPPQL----------SPRSHLCPPPPHPTPPQLNNLLLLEGRKSSLPSVAPTG- 50
Y ++ PPQ SPR L P + L + + +S+ ++P
Sbjct: 424 YVNTQQIPPQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISPVSP 483
Query: 51 -SASAAEDSDLLTQPWYSGNCDRYAVESALLHLQKDGAYTVRPSSGPHGSQPFTLAVLLR 109
+ A +L + WY G R E L +KDG + VR S+ GS F L +
Sbjct: 484 RAPDAKMLEELQAETWYQGEMSRKEAEGLL---EKDGDFLVRKSTTNPGS--FVLTGMHN 538
Query: 110 GRVFNIPIRRLDGGRHYALGREGRNREELFSSVAAMVQHFMWHPLPLVDRHSGSRELTCL 169
G+ ++ + +G R ++ +F S++ ++ H + LP+V S EL CL
Sbjct: 539 GQAKHLLLVDPEGTI--------RTKDRVFDSISHLINHHLESSLPIV---SAGSEL-CL 586
Query: 170 LFPTK 174
P +
Sbjct: 587 QQPVE 591
>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
sapiens]
Length = 2715
Score = 39.3 bits (90), Expect = 0.002
Identities = 30/96 (31%), Positives = 35/96 (36%), Gaps = 17/96 (17%)
Query: 8 PPPQLSPRSHLCPPPPHPTPPQLNNLLLLEGRKSSLPSVAPTGSASAAEDSDLLTQPWYS 67
PPP SP LCPPPP P P LPS P + E+S P
Sbjct: 418 PPPSTSPPPPLCPPPPPPVSP------------PPLPSPPPPPAQEEQEES---PPPVVP 462
Query: 68 GNCDRYAVESALLHLQKDGAYTVRPSSGPHGSQPFT 103
C R L Q+ R +GP G+ P T
Sbjct: 463 ATCSRKRGRPPLTPSQRAEREAAR--AGPEGTSPPT 496
Score = 29.6 bits (65), Expect = 1.4
Identities = 17/42 (40%), Positives = 20/42 (47%), Gaps = 10/42 (23%)
Query: 7 PPPPQLSPRSHLCPPPPHPTPPQLNNLLLLEGRKSSLPSVAP 48
PPPP +SP PP P P PP E ++ S P V P
Sbjct: 431 PPPPPVSP-----PPLPSPPPPPAQ-----EEQEESPPPVVP 462
>gi|222537752 Src homology 2 domain containing transforming protein
D [Homo sapiens]
Length = 340
Score = 37.4 bits (85), Expect = 0.007
Identities = 43/135 (31%), Positives = 56/135 (41%), Gaps = 29/135 (21%)
Query: 48 PTGSASAAEDSD----LLTQPWYSGNCDRYAVESALLHLQKDGAYTVRPSSGPHGSQPFT 103
P S AE D L QPW+ G +R ES LL L K+G+Y VR S + P
Sbjct: 219 PPRSPQPAERVDPALPLEKQPWFHGPLNRADAES-LLSLCKEGSYLVRLSE----TNPQD 273
Query: 104 LAVLLRGRVFNIPIRRLDGGRHYALGREGRNREEL------FSSVAAMVQHFMWHPLPLV 157
++ LR G H R N+ L F SV +V H+ PLP+
Sbjct: 274 CSLSLRSS---------QGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPV- 323
Query: 158 DRHSGSRELTCLLFP 172
G+ L LL+P
Sbjct: 324 ---QGAEHL-ALLYP 334
>gi|208609985 SH2 domain containing 3A [Homo sapiens]
Length = 576
Score = 37.4 bits (85), Expect = 0.007
Identities = 33/105 (31%), Positives = 49/105 (46%), Gaps = 12/105 (11%)
Query: 56 EDSDLLTQPWYSGNCDRYAVESALLHLQKDGAYTVRPSSGPHGSQPFTLAVLLRGRVFNI 115
+ DL QPWY G R E+ LQ++G + VR +SG G P ++ RG +
Sbjct: 6 DGEDLAGQPWYHGLLSRQKAEAL---LQQNGDFLVR-ASGSRGGNP-VISCRWRGSALHF 60
Query: 116 PIRRL----DGGRHYALGREGRNREELFSSVAAMVQHFMWHPLPL 156
+ R+ GR AL + +E F S+ A+V +M PL
Sbjct: 61 EVFRVALRPRPGRPTAL---FQLEDEQFPSIPALVHSYMTGRRPL 102
>gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo
sapiens]
Length = 475
Score = 36.6 bits (83), Expect = 0.011
Identities = 39/170 (22%), Positives = 62/170 (36%), Gaps = 38/170 (22%)
Query: 8 PPPQLSPRSHLCPPPPHPTPPQLNNLLLLEG-------RKSSLPSVAPTGSASAAEDSDL 60
P P+ SP+ L P +L+ + G + PS + A + L
Sbjct: 316 PEPEDSPKKDLFDMRPFEDALKLHECSVAAGVTAAPLPLEDQWPSPPTRRAPVAPTEEQL 375
Query: 61 LTQPWYSGNCDRYAVESALLHLQKDGAYTVRPS---------SGPHGSQPFTLAVLLRGR 111
+PWY G R A E L+ DG + VR S +G H QP L ++
Sbjct: 376 RQEPWYHGRMSRRAAERM---LRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEG 432
Query: 112 VFNIPIRRLDGGRHYALGREGRNREELFSSVAAMVQHFMWHPLPLVDRHS 161
V R ++ LF S++ ++ H + + P+V S
Sbjct: 433 VV-------------------RTKDVLFESISHLIDHHLQNGQPIVAAES 463
>gi|169790811 SHC (Src homology 2 domain containing) transforming
protein 2 [Homo sapiens]
Length = 582
Score = 36.6 bits (83), Expect = 0.011
Identities = 39/170 (22%), Positives = 62/170 (36%), Gaps = 38/170 (22%)
Query: 8 PPPQLSPRSHLCPPPPHPTPPQLNNLLLLEG-------RKSSLPSVAPTGSASAAEDSDL 60
P P+ SP+ L P +L+ + G + PS + A + L
Sbjct: 423 PEPEDSPKKDLFDMRPFEDALKLHECSVAAGVTAAPLPLEDQWPSPPTRRAPVAPTEEQL 482
Query: 61 LTQPWYSGNCDRYAVESALLHLQKDGAYTVRPS---------SGPHGSQPFTLAVLLRGR 111
+PWY G R A E L+ DG + VR S +G H QP L ++
Sbjct: 483 RQEPWYHGRMSRRAAERM---LRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEG 539
Query: 112 VFNIPIRRLDGGRHYALGREGRNREELFSSVAAMVQHFMWHPLPLVDRHS 161
V R ++ LF S++ ++ H + + P+V S
Sbjct: 540 VV-------------------RTKDVLFESISHLIDHHLQNGQPIVAAES 570
>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 878
Score = 36.6 bits (83), Expect = 0.011
Identities = 29/127 (22%), Positives = 54/127 (42%), Gaps = 14/127 (11%)
Query: 48 PTGSASAAEDSDLLTQPWYSGNCDRYAVESALLHLQKDGAYTVRPSSGPHGSQPFTLAVL 107
P S + + D PW++GN +R ++ LL G Y +R P ++ F +++
Sbjct: 656 PPISRPPSREIDYTAYPWFAGNMERQQTDN-LLKSHASGTYLIR--ERPAEAERFAISIK 712
Query: 108 LRGRVFNIPIRRLDGGRHYALGREGRNREELFSSVAAMVQHFMWHPLPLVDRHSGSRELT 167
V +I + D H ++ F S+ +V+++ H L + S + T
Sbjct: 713 FNDEVKHIKVVEKDNWIHITEAKK-------FDSLLELVEYYQCHSL----KESFKQLDT 761
Query: 168 CLLFPTK 174
L +P K
Sbjct: 762 TLKYPYK 768
>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 839
Score = 36.6 bits (83), Expect = 0.011
Identities = 29/127 (22%), Positives = 54/127 (42%), Gaps = 14/127 (11%)
Query: 48 PTGSASAAEDSDLLTQPWYSGNCDRYAVESALLHLQKDGAYTVRPSSGPHGSQPFTLAVL 107
P S + + D PW++GN +R ++ LL G Y +R P ++ F +++
Sbjct: 646 PPISRPPSREIDYTAYPWFAGNMERQQTDN-LLKSHASGTYLIR--ERPAEAERFAISIK 702
Query: 108 LRGRVFNIPIRRLDGGRHYALGREGRNREELFSSVAAMVQHFMWHPLPLVDRHSGSRELT 167
V +I + D H ++ F S+ +V+++ H L + S + T
Sbjct: 703 FNDEVKHIKVVEKDNWIHITEAKK-------FDSLLELVEYYQCHSL----KESFKQLDT 751
Query: 168 CLLFPTK 174
L +P K
Sbjct: 752 TLKYPYK 758
>gi|157168329 formin 1 [Homo sapiens]
Length = 1196
Score = 36.2 bits (82), Expect = 0.015
Identities = 15/26 (57%), Positives = 16/26 (61%)
Query: 7 PPPPQLSPRSHLCPPPPHPTPPQLNN 32
PPPP L P S PPPP P PP N+
Sbjct: 685 PPPPPLPPPSSAGPPPPPPPPPLPNS 710
Score = 26.9 bits (58), Expect = 9.0
Identities = 12/24 (50%), Positives = 13/24 (54%)
Query: 4 SSYPPPPQLSPRSHLCPPPPHPTP 27
S PP P +S L PPPP P P
Sbjct: 666 SPAPPMPPVSAGPPLPPPPPPPPP 689
>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
Length = 1047
Score = 36.2 bits (82), Expect = 0.015
Identities = 32/103 (31%), Positives = 37/103 (35%), Gaps = 2/103 (1%)
Query: 12 LSPRSHLCPPPPHPTPPQLNNLLLLEGRKSSLPSVAPTGSASAAEDSDLLTQPWYSGNCD 71
L P P PP P P L L SL A + T WY G D
Sbjct: 128 LGPGGGFPPLPPPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQWYHGKLD 187
Query: 72 RYAVESALLHLQKDGAYTVRPSSGPHGSQPFTLAVLLRGRVFN 114
R E L K G+Y +R S GS F L+ L + V N
Sbjct: 188 RTIAEERLRQAGKSGSYLIRESDRRPGS--FVLSFLSQMNVVN 228
>gi|128485756 hexaribonucleotide binding protein 3 [Homo sapiens]
Length = 312
Score = 36.2 bits (82), Expect = 0.015
Identities = 35/130 (26%), Positives = 47/130 (36%), Gaps = 13/130 (10%)
Query: 4 SSYPPPPQLSPRSHLCPPPPHPTPPQLNNLLLLEGRKSSLPSVAPTGSASAAEDSDLLTQ 63
+ YPPPPQ + PPPPHPT + +L + A T S+ TQ
Sbjct: 8 AQYPPPPQNGIPAEYAPPPPHPTQDYSGQTPVPTEHGMTLYTPAQTHPEQPG--SEASTQ 65
Query: 64 PWYSGNCDRYAVESALLHLQKDGAYTVRPSSGPHGSQPFTLAVLLRGRVFNIPIRRLDGG 123
P E+A + + + PS QP L V NIP R D
Sbjct: 66 PIAGTQTVPQTDEAA-----QTDSQPLHPSDPTEKQQPKRL------HVSNIPFRFRDPD 114
Query: 124 RHYALGREGR 133
G+ G+
Sbjct: 115 LRQMFGQFGK 124
>gi|91208437 GEM interacting protein [Homo sapiens]
Length = 970
Score = 36.2 bits (82), Expect = 0.015
Identities = 30/96 (31%), Positives = 40/96 (41%), Gaps = 4/96 (4%)
Query: 4 SSYPPPPQLSPRSHLCPPPPHPTP-PQLNNLLLLEGRKSSLPSVAPTGSASAAEDSDLLT 62
SS PPPP L P S PP P P + LE ++ P+ PT + ED T
Sbjct: 783 SSQPPPPHLDPDSQ--PPVLASDPGPDPQHHSTLEQHPTATPTEIPTPQSDQREDVAEDT 840
Query: 63 QPWYSGNCDRYAVESALLHLQKDGAYTVRPSSGPHG 98
+ G E +LL Q G ++ +P P G
Sbjct: 841 KDG-GGEVSSQGPEDSLLGTQSRGHFSRQPVKYPRG 875
>gi|150378503 leiomodin 2 (cardiac) [Homo sapiens]
Length = 547
Score = 35.0 bits (79), Expect = 0.033
Identities = 14/24 (58%), Positives = 14/24 (58%)
Query: 7 PPPPQLSPRSHLCPPPPHPTPPQL 30
PPPP P S PPPP P PP L
Sbjct: 426 PPPPPPPPSSQRLPPPPPPPPPPL 449
Score = 28.1 bits (61), Expect = 4.1
Identities = 12/23 (52%), Positives = 13/23 (56%)
Query: 7 PPPPQLSPRSHLCPPPPHPTPPQ 29
PPPP S R PPPP P P+
Sbjct: 429 PPPPPSSQRLPPPPPPPPPPLPE 451
>gi|38683860 insulin receptor substrate 2 [Homo sapiens]
Length = 1338
Score = 34.7 bits (78), Expect = 0.043
Identities = 15/27 (55%), Positives = 16/27 (59%)
Query: 7 PPPPQLSPRSHLCPPPPHPTPPQLNNL 33
PP P SP S L PPPP P P +L L
Sbjct: 1018 PPRPSASPSSSLQPPPPPPAPGELYRL 1044
Score = 26.9 bits (58), Expect = 9.0
Identities = 14/34 (41%), Positives = 19/34 (55%)
Query: 20 PPPPHPTPPQLNNLLLLEGRKSSLPSVAPTGSAS 53
PPPP P PP + L G++ S S + +GS S
Sbjct: 460 PPPPGPHPPLPHPLHHGPGQRPSSGSASASGSPS 493
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.431
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,606,857
Number of Sequences: 37866
Number of extensions: 548609
Number of successful extensions: 6682
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 237
Number of HSP's successfully gapped in prelim test: 233
Number of HSP's that attempted gapping in prelim test: 4337
Number of HSP's gapped (non-prelim): 2027
length of query: 175
length of database: 18,247,518
effective HSP length: 95
effective length of query: 80
effective length of database: 14,650,248
effective search space: 1172019840
effective search space used: 1172019840
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 58 (26.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.