Guide to the Human Genome
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Name: PAPPA Sequence: fasta or formatted (1627aa) NCBI GI: 38045915
Description:

pregnancy-associated plasma protein A preproprotein

Referenced in:

Growth Hormone and Related Hormones
Additional Interaction Domain Families
Ovary, Uterus and Placenta

Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             6.1         99           3
 C cysteine            5.2         84           2
 D aspartate           6.3        102           3
 E glutamate           5.2         85           3
 F phenylalanine       3.6         58           2
 G glycine             7.0        114           2
 H histidine           3.7         61           2
 I isoleucine          3.7         60           2
 K lysine              3.7         61           2
 L leucine             7.7        126           3
 M methionine          1.5         24           1
 N asparagine          4.2         68           2
 P proline             7.1        115           7
 Q glutamine           5.1         83           2
 R arginine            5.0         82           3
 S serine              8.1        131           3
 T threonine           5.4         88           2
 V valine              6.3        103           2
 W tryptophan          1.8         30           1
 Y tyrosine            3.3         53           2
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   pregnancy-associated plasma protein A preproprotein ... 
PAPPA2                0.428   pappalysin 2 isoform 1 
PAPPA2                0.163   pappalysin 2 isoform 2 
SELP                  0.020   selectin P precursor 
SELE                  0.019   selectin E precursor 
SVEP1                 0.017   polydom 
CSMD1                 0.017   CUB and Sushi multiple domains 1 
CSMD2                 0.015   CUB and Sushi multiple domains 2 
SRPX2                 0.014   sushi-repeat-containing protein, X-linked 2 
CSMD3                 0.013   CUB and Sushi multiple domains 3 isoform 2 
CSMD3                 0.013   CUB and Sushi multiple domains 3 isoform 3 
CSMD3                 0.013   CUB and Sushi multiple domains 3 isoform 1 
CR1                   0.013   complement receptor 1 isoform S precursor 
CR1                   0.013   complement receptor 1 isoform F precursor 
CR2                   0.011   complement component (3d/Epstein Barr virus) recepto...
C4BPA                 0.011   complement component 4 binding protein, alpha chain p...
CR2                   0.011   complement component (3d/Epstein Barr virus) recepto...
CD55                  0.010   decay accelerating factor for complement isoform 2 ...
CD55                  0.010   decay accelerating factor for complement isoform 1 p...
CFH                   0.010   complement factor H isoform a precursor 
F13B                  0.010   coagulation factor XIII B subunit precursor 
CR1L                  0.010   complement component (3b/4b) receptor 1-like 
SRPX                  0.009   sushi-repeat-containing protein, X-linked 
CFHR1                 0.009   complement factor H-related 1 
LOC100293069          0.009   PREDICTED: similar to complement factor H-related 1...
CFH                   0.009   complement factor H isoform b precursor 
MEGF6                 0.009   EGF-like-domain, multiple 3 
CFHR2                 0.008   H factor (complement)-like 3 
SELL                  0.008   selectin L precursor 
C2                    0.007   complement component 2 isoform 1 preproprotein [Homo...
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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