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Search of human proteins with 30795231
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|30795231 brain abundant, membrane attached signal protein 1
[Homo sapiens]
(227 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|30795231 brain abundant, membrane attached signal protein 1 [... 445 e-125
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 85 6e-17
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 79 3e-15
gi|153070260 myristoylated alanine-rich protein kinase C substra... 75 5e-14
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 75 6e-14
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 74 1e-13
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 74 1e-13
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 74 1e-13
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 74 1e-13
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 74 1e-13
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 74 1e-13
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 74 1e-13
gi|33286446 opioid growth factor receptor [Homo sapiens] 68 7e-12
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 68 7e-12
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 68 7e-12
gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo sap... 66 2e-11
gi|194248057 growth associated protein 43 isoform 1 [Homo sapiens] 66 2e-11
gi|4503911 growth associated protein 43 isoform 2 [Homo sapiens] 66 2e-11
gi|210032580 SET domain containing 1B [Homo sapiens] 65 4e-11
gi|163965366 nascent polypeptide-associated complex alpha subuni... 65 4e-11
gi|189181724 proteoglycan 4 isoform D [Homo sapiens] 63 2e-10
gi|189181722 proteoglycan 4 isoform C [Homo sapiens] 63 2e-10
gi|189181720 proteoglycan 4 isoform B [Homo sapiens] 63 2e-10
gi|67190163 proteoglycan 4 isoform A [Homo sapiens] 63 2e-10
gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo sap... 63 2e-10
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 62 3e-10
gi|42518068 trans-golgi network protein 2 [Homo sapiens] 62 3e-10
gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens] 62 4e-10
gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithora... 60 2e-09
gi|157738619 smoothelin-like 1 [Homo sapiens] 60 2e-09
>gi|30795231 brain abundant, membrane attached signal protein 1
[Homo sapiens]
Length = 227
Score = 445 bits (1144), Expect = e-125
Identities = 227/227 (100%), Positives = 227/227 (100%)
Query: 1 MGGKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQ 60
MGGKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQ
Sbjct: 1 MGGKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQ 60
Query: 61 DAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAP 120
DAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAP
Sbjct: 61 DAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAP 120
Query: 121 KAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAA 180
KAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAA
Sbjct: 121 KAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAA 180
Query: 181 PSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
PSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVKE
Sbjct: 181 PSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 84.7 bits (208), Expect = 6e-17
Identities = 64/210 (30%), Positives = 95/210 (45%), Gaps = 14/210 (6%)
Query: 20 KEKDKKAEGAATEEEGTPKESE--------PQAAAEPAEAKEGKEKPDQDAEGKAEEKEG 71
+EK+ K E EE G +E+E P A + KE K ++A+ AE K
Sbjct: 474 EEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSP 533
Query: 72 EKDAAAAKEEAPKAEPEKTEGAAEAKAEP-PKAPEQEQA-APGPAAGGEAPK--AAEAAA 127
EK+ A + E E K+ EAK+ P K+PE+E+A +P E K A E A
Sbjct: 534 EKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAK 593
Query: 128 APAESAAPAAGEEPSKEEGE-PKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKET 186
+PAE+ +P + P KEE + P + ++P A+ +P P EA K
Sbjct: 594 SPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAK 653
Query: 187 PAATEAPSSTPKAQGPA-ASAEEPKPVEAP 215
E S KA+ P A A+ P+ ++P
Sbjct: 654 SPEKEEAKSPEKAKSPVKAEAKSPEKAKSP 683
Score = 80.9 bits (198), Expect = 8e-16
Identities = 70/224 (31%), Positives = 112/224 (50%), Gaps = 26/224 (11%)
Query: 14 VNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEK 73
V +E +E++K+A+ EEEG +E + AE E + ++ A + E K K
Sbjct: 466 VTEEVTEEEEKEAK----EEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVK 521
Query: 74 DAAAAKEEAPKAEPEKTEGAAEAKA-EPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAES 132
+ A + EA E E+ + AE K+ E K+P +E+A P A ++P+ E A +PAE
Sbjct: 522 EEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEA--KSPE-KEEAKSPAEV 578
Query: 133 AAPAAGEEPSKEE----GEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEA-APSSKETP 187
+P + P+KEE E K E +P +E KS PA P EA +P+ ++P
Sbjct: 579 KSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKS---PAEAKSPVKEEAKSPAEVKSP 635
Query: 188 AATEAPS-----STPKAQGP----AASAEEPK-PVEAPAANSDQ 221
++P+ S KA+ P A S E+ K PV+A A + ++
Sbjct: 636 EKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEK 679
Score = 77.8 bits (190), Expect = 7e-15
Identities = 70/214 (32%), Positives = 101/214 (47%), Gaps = 24/214 (11%)
Query: 17 EKAKEKDKKAEGAATEEEGTPKES---EPQAAAEPAEAKE-------GKEKPDQDAEGKA 66
E+A +K+A+ EE +P E+ E + A PAE K KE+ E K+
Sbjct: 507 EEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKS 566
Query: 67 EEKEGEKDAAAAK--EEAPKAEPEKTEGAAEAKA-EPPKAPEQEQAAPGPAAGGEAPKAA 123
EKE K A K E+A E+ + AEAK+ E K+P +E+ A PA K
Sbjct: 567 PEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEE-AKSPAEAKSPVK-- 623
Query: 124 EAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEA-APS 182
E A +PAE +P + P+KEE K E +P +E KS P P +EA +P
Sbjct: 624 EEAKSPAEVKSPEKAKSPTKEEA--KSPEKAKSPEKEEAKS---PEKAKSPVKAEAKSPE 678
Query: 183 SKETPAATEAPSSTPKAQGPA-ASAEEPKPVEAP 215
++P EA S KA+ P A+ P+ ++P
Sbjct: 679 KAKSPVKAEA-KSPEKAKSPVKEEAKSPEKAKSP 711
Score = 73.9 bits (180), Expect = 1e-13
Identities = 71/231 (30%), Positives = 107/231 (46%), Gaps = 32/231 (13%)
Query: 18 KAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAA 77
K++EK K E +E+E E + + E E +EK ++ EGK EE+ GE++ A
Sbjct: 439 KSEEKIKVVE--KSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGK-EEEGGEEEEAE 495
Query: 78 AKEEAPKAEPEKTEGAAEAKAEPP-----------KAPEQEQA-APGPAAGGEAPK--AA 123
EE K+ P + + E +A+ P K+PE+E+A +P E K A
Sbjct: 496 GGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAK 555
Query: 124 EAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDG---APASDSKPGSSEA- 179
E A +P E+ +P +E +K E K E +PA +E KS +P P EA
Sbjct: 556 EEAKSPPEAKSPE--KEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAK 613
Query: 180 APSSKETPAATEAPS-----STPKAQGP----AASAEEPKPVEAPAANSDQ 221
+P+ ++P EA S S KA+ P A S E+ K E A S +
Sbjct: 614 SPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPE 664
Score = 73.6 bits (179), Expect = 1e-13
Identities = 64/237 (27%), Positives = 104/237 (43%), Gaps = 19/237 (8%)
Query: 4 KLSKKKKGYNVNDEKAKEKDK---KAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQ 60
K +K++ + + K+ EK K K E + E +P++ E ++ AE ++ K +
Sbjct: 531 KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKE 590
Query: 61 DAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKA-------EPPKAPEQEQAAPGP 113
+A+ AE K EK + KEEA K+ EAK+ E K+P +E+A
Sbjct: 591 EAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPE 650
Query: 114 AAGG---EAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPAS 170
A E K+ E A +P ++ A + + S + E K E +P +E KS P
Sbjct: 651 KAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKS---PEK 707
Query: 171 DSKPGSSEA-APSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVK 226
P EA +P ++P EA TP+ E P +A + +T+ VK
Sbjct: 708 AKSPVKEEAKSPEKAKSPVKEEA--KTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVK 762
Score = 73.6 bits (179), Expect = 1e-13
Identities = 74/238 (31%), Positives = 95/238 (39%), Gaps = 38/238 (15%)
Query: 17 EKAKEKDKKAEGAAT---EEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEK 73
EKAK D K+ A T EE +P + P+ A P KE+ + K+ KE
Sbjct: 754 EKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPV-----KEEVKSPEKAKSPLKE--- 805
Query: 74 DAAAAKEEAPKAEPEKTEGAAEAK------AEPPKAPEQEQAAPGP------------AA 115
DA A ++E PK E K+ E K EPPK E+E+A P A
Sbjct: 806 DAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAP 865
Query: 116 GGEAPK-AAEAAAAPAESAAPAAGEEPSKEEGEPKK---TEAPAAPAAQETKSDGAP--- 168
EAPK E PA + E KEE E KK T APA E K D P
Sbjct: 866 KKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEK 925
Query: 169 --ASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVT 224
+ +P ++A SK AP + A EE EA A D+T++
Sbjct: 926 TEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLS 983
Score = 68.9 bits (167), Expect = 3e-12
Identities = 66/216 (30%), Positives = 94/216 (43%), Gaps = 26/216 (12%)
Query: 24 KKAEGAATEEEGTPKESE-PQAAAEPA--EAK---EGKEKPDQDAEGKAEEKEGEKDAAA 77
+KA+ A EE +P E++ P+ A P EAK E K ++A+ AE K EK +
Sbjct: 582 EKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSP 641
Query: 78 AKEEAPKAE----PEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPA--E 131
KEEA E PEK E + KA+ P E + + K+ E A +P E
Sbjct: 642 TKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEE 701
Query: 132 SAAPAAGEEPSKEEGE-PKKTEAPA-----------APAAQETKSDGAPASDSKPGSSEA 179
+ +P + P KEE + P+K ++P +P +E KS S K + +
Sbjct: 702 AKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDV 761
Query: 180 APSSKETPAATEAPSSTPKAQGPAAS--AEEPKPVE 213
+TPA EA S K A S EE K E
Sbjct: 762 KSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPE 797
Score = 68.6 bits (166), Expect = 4e-12
Identities = 72/261 (27%), Positives = 104/261 (39%), Gaps = 40/261 (15%)
Query: 4 KLSKKKKGYNVNDEKAKEKDK---KAEGAATEEEGTPKESE---PQAAAEPAEAKEGKEK 57
K +K K + K+ EK K KAE + E+ +P + E P+ A P + +E K
Sbjct: 661 KSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVK-EEAKSP 719
Query: 58 PDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGG 117
+ K E K EK + KEEA PEK + +AK K+PE + A A
Sbjct: 720 EKAKSPVKEEAKTPEKAKSPVKEEAKS--PEKAKSPEKAKTLDVKSPEAKTPAKEEARSP 777
Query: 118 -------------EAPKAAEAAAAPAESAAPAAGEE---------PSKEEGEPKKTEAPA 155
E K+ E A +P + A A +E P KEE +P++ +
Sbjct: 778 ADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKE 837
Query: 156 AP-AAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAAS--------A 206
P A+E K+ P ++ K S + KE P P + P S A
Sbjct: 838 PPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEA 897
Query: 207 EEPKPVEAPAANSDQTVTVKE 227
E+ K V P + V VKE
Sbjct: 898 EDKKKVPTPEKEAPAKVEVKE 918
Score = 66.2 bits (160), Expect = 2e-11
Identities = 61/228 (26%), Positives = 94/228 (41%), Gaps = 27/228 (11%)
Query: 4 KLSKKKKGYNVNDEKAKEKD---KKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQ 60
K +K K D KA EK+ K+ + +EE P+E + + + AE ++ P
Sbjct: 794 KSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATP-- 851
Query: 61 DAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAP 120
K EEK+ K A K+EAPK + E+ + A K + K +++ A
Sbjct: 852 ----KTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPE 907
Query: 121 KAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAP--------AAPAAQETKSDGAPASDS 172
K A A E A P E +K+E + K + P AAP ++TK + A +
Sbjct: 908 KEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEE 967
Query: 173 KPGSSEAA----------PSSKETPAATEAPSSTPKAQGPAASAEEPK 210
KP + A PS + A ++ S+ K P A E K
Sbjct: 968 KPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDK 1015
Score = 62.4 bits (150), Expect = 3e-10
Identities = 66/226 (29%), Positives = 97/226 (42%), Gaps = 30/226 (13%)
Query: 20 KEKDKKAEGAATEEEGTPKESE---PQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAA 76
+E AE + E+ +P + E P+ A P E +E K + KAE K EK +
Sbjct: 624 EEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSP-EKEEAKSPEKAKSPVKAEAKSPEKAKS 682
Query: 77 AAKEEAPKAEPEKTEGAAEAKA-EPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPA--ESA 133
K EA E K+ EAK+ E K+P +E+A K+ E A +P E+
Sbjct: 683 PVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEA-----------KSPEKAKSPVKEEAK 731
Query: 134 APAAGEEPSKEEGE-PKKTEAPAAPAAQETKSDGA--PASDSKPGSSEAAPSSKETPAAT 190
P + P KEE + P+K ++P + KS A PA + ++ P ++P
Sbjct: 732 TPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKE 791
Query: 191 EAPS-----STPKAQGPAASAEEPK--PVEAPAANSD--QTVTVKE 227
E S S K A E PK V++P + Q V VKE
Sbjct: 792 EVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKE 837
Score = 48.5 bits (114), Expect = 5e-06
Identities = 41/150 (27%), Positives = 63/150 (42%), Gaps = 15/150 (10%)
Query: 7 KKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKA 66
+K K V +K + +DKK T E+ P + E + A+P E E +K DA+ K
Sbjct: 883 EKPKESKVEAKKEEAEDKKK--VPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKE 940
Query: 67 EEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAA 126
K EK KE AP+ + + K E K PE++ A + + E +
Sbjct: 941 PSKPAEK-----KEAAPEKK--------DTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPS 987
Query: 127 AAPAESAAPAAGEEPSKEEGEPKKTEAPAA 156
AE A ++ + + K TE AA
Sbjct: 988 KPKAEKAEKSSSTDQKDSKPPEKATEDKAA 1017
Score = 46.2 bits (108), Expect = 2e-05
Identities = 35/103 (33%), Positives = 54/103 (52%), Gaps = 8/103 (7%)
Query: 16 DEKAKEKD----KKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEG 71
D K KEK K+ + A +E P E + +AA E + KE K K ++ + K E K
Sbjct: 919 DAKPKEKTEVAKKEPDDAKAKEPSKPAEKK-EAAPEKKDTKEEKAKKPEE-KPKTEAKAK 976
Query: 72 EKDAAAAKEEA-PKAEP-EKTEGAAEAKAEPPKAPEQEQAAPG 112
E D +KE + PKAE EK+ + ++PP+ +++AA G
Sbjct: 977 EDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKG 1019
Score = 41.6 bits (96), Expect = 6e-04
Identities = 47/170 (27%), Positives = 68/170 (40%), Gaps = 33/170 (19%)
Query: 65 KAEEK-----EGEKDAAAAKEEAPKAE-PEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGE 118
K+EEK + EK+ +E+ + + E+ E +A+ + E+E A GGE
Sbjct: 439 KSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGE 498
Query: 119 APKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSE 178
E + PAE AA P KE P K EA + PA P E
Sbjct: 499 E----ETKSPPAEEAA-----SPEKEAKSPVKEEAKS------------PAEAKSPEKEE 537
Query: 179 A-APSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
A +P+ ++P ++P A+ A S E K E A S V E
Sbjct: 538 AKSPAEVKSPEKAKSP-----AKEEAKSPPEAKSPEKEEAKSPAEVKSPE 582
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 79.0 bits (193), Expect = 3e-15
Identities = 64/199 (32%), Positives = 93/199 (46%), Gaps = 14/199 (7%)
Query: 32 EEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTE 91
+ +G P+A E EG E P+ AEG A+E EGE + EAP+AE
Sbjct: 1828 QSDGAEGIEAPEAEGEAQPESEGVEAPE--AEGDAQEAEGEAQPESEDVEAPEAE----- 1880
Query: 92 GAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAES--AAPAAGE-EPSKEEGEP 148
G A+ ++E + PE E + G EAP+A + A ES A GE EP E E
Sbjct: 1881 GEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEA 1940
Query: 149 KKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEE 208
++ E A A +T+ + + +S+ EA P S++ A E T +A+G A E
Sbjct: 1941 QEAEEAAQEAEGQTQPE-SEVIESQEAEEEAQPESEDV-EALEVEVETQEAEGEA--QPE 1996
Query: 209 PKPVEAPAANSDQTVTVKE 227
+ VEAP A + +E
Sbjct: 1997 SEDVEAPEAEGEMQEAEEE 2015
Score = 77.4 bits (189), Expect = 9e-15
Identities = 58/209 (27%), Positives = 100/209 (47%), Gaps = 15/209 (7%)
Query: 16 DEKAKEKDKKAEGAATEEEGTPKE--SEPQAAAEPAEAKEGKEKPDQDA-EGKAEEKEGE 72
+++A+ + + E TE E P+ +E Q A E A+ EG+ +P+ + E + E+E +
Sbjct: 1912 EKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQ 1971
Query: 73 KDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAES 132
++ + + E ++ EG A+ ++E +APE E EA + A+ + E+
Sbjct: 1972 PESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQ------EAEEEAQPESDGVEA 2025
Query: 133 AAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEA 192
+ GEE + EGE +KTE A P +SDG A +++ + EA +E
Sbjct: 2026 QPKSEGEEAQEVEGETQKTEGDAQP-----ESDGVEAPEAEEEAQEAEGEVQEAEGEAHP 2080
Query: 193 PSSTPKAQGPAASAE-EPKPVEAPAANSD 220
S AQ A+ E + VEAP A +
Sbjct: 2081 ESEDVDAQEAEGEAQPESEGVEAPEAEGE 2109
Score = 74.3 bits (181), Expect = 8e-14
Identities = 75/229 (32%), Positives = 107/229 (46%), Gaps = 31/229 (13%)
Query: 16 DEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDA 75
+E+A+ + + E E E E E Q +E EA E E Q+AE EE + E D
Sbjct: 1967 EEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEA-EGEMQEAE---EEAQPESDG 2022
Query: 76 AAAK-----EEAPKAEPE--KTEGAAEAKA---EPPKAPEQEQAAPGPA--AGGEAPKAA 123
A+ EEA + E E KTEG A+ ++ E P+A E+ Q A G A GEA +
Sbjct: 2023 VEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPES 2082
Query: 124 E---AAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPAS---DSKPGSS 177
E A A E+ + G E + EGE +K E AP ET+ + P S ++
Sbjct: 2083 EDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAP---ETEGEAQPESEGIEAPEAEG 2139
Query: 178 EAAPSSKETPAATEAPSSTPKAQGPAA--SAEEPKP----VEAPAANSD 220
EA P S+ A + P+++G A + EE +P VEAP A +
Sbjct: 2140 EAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGE 2188
Score = 72.8 bits (177), Expect = 2e-13
Identities = 68/217 (31%), Positives = 103/217 (47%), Gaps = 28/217 (12%)
Query: 17 EKAKEKDKKAEGAATEE----EGTPKESEPQAAAEPAEAKEGKEKPD------QDAEGKA 66
++ + + +K EG A E E E E Q A + EG+ P+ Q+AEG+A
Sbjct: 2035 QEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEA 2094
Query: 67 EEKEGEKDAAAAKEEAPKA---EPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAA 123
+ + +A A+ EA KA E +TEG A+ ++E +APE E A + G EA + A
Sbjct: 2095 QPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEA-QDA 2153
Query: 124 EAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSS 183
E A P ES A E + + E + EAP A + +S+G A +++ EA P
Sbjct: 2154 EGEAQP-ESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAE---GEAQPEL 2209
Query: 184 KETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSD 220
+ EAP + +AQ EP+ VE P A +
Sbjct: 2210 E----GVEAPEAEEEAQ------PEPEGVETPEAEGE 2236
Score = 72.0 bits (175), Expect = 4e-13
Identities = 65/208 (31%), Positives = 98/208 (47%), Gaps = 23/208 (11%)
Query: 14 VNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPD------QDAEGKAE 67
V +A+ + +KAEG E T E++P++ A EG+ +P+ QDAEG+A+
Sbjct: 2101 VEAPEAEGEAQKAEGIEAPE--TEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQ 2158
Query: 68 EKEGEKDAAAAKEEAPK----AEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAA 123
+ +A A+EEA E + EG A+ ++E +APE E A G EAP+A
Sbjct: 2159 PESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAE 2218
Query: 124 EAAAAPAE--SAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAP 181
E A E A GE + EGE T+ + Q + DG S+ SS P
Sbjct: 2219 EEAQPEPEGVETPEAEGEAQPESEGE---TQGEKKGSPQVSLGDG--QSEEASESSSPVP 2273
Query: 182 SSKETPAAT---EAPSSTPKAQ-GPAAS 205
+ TP + + P P +Q GP++S
Sbjct: 2274 EDRPTPPPSPGGDTPHQRPGSQTGPSSS 2301
Score = 70.5 bits (171), Expect = 1e-12
Identities = 69/242 (28%), Positives = 104/242 (42%), Gaps = 45/242 (18%)
Query: 14 VNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAK-----EGKEKPD-----QDAE 63
V +A+E+ ++AEG E EG A+ AE + EG E P+ Q AE
Sbjct: 2055 VEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAE 2114
Query: 64 G-KAEEKEGEKDAAAAKEEAPKAEPEK-----------TEGAAEAKAEPPKAPEQEQAAP 111
G +A E EGE + EAP+AE E EG A+ ++E +A E E+ A
Sbjct: 2115 GIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQ 2174
Query: 112 GPAAGGEAPKAAEAAAAPAES--AAPAAGEEPSKEEG------------EPKKTEAPAAP 157
G EAP+A A +E A A GE + EG EP+ E P A
Sbjct: 2175 PELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAE 2234
Query: 158 AAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAA 217
+ +S+G + K GS + + ++ A+E+ S P+ + P P +P
Sbjct: 2235 GEAQPESEGETQGEKK-GSPQVSLGDGQSEEASESSSPVPE--------DRPTPPPSPGG 2285
Query: 218 NS 219
++
Sbjct: 2286 DT 2287
Score = 68.9 bits (167), Expect = 3e-12
Identities = 63/215 (29%), Positives = 90/215 (41%), Gaps = 33/215 (15%)
Query: 24 KKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDA---EGKAEEKEGEKDAAAAKE 80
++AE AA E EG + ++ AE + E D +A E + +E EGE +
Sbjct: 1941 QEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDV 2000
Query: 81 EAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAES-------- 132
EAP+AE E E EA+ PE + P + GE + E E
Sbjct: 2001 EAPEAEGEMQEAEEEAQ------PESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDG 2054
Query: 133 -AAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATE 191
AP A EE + EGE ++ E A P +++ D++ EA P S E A E
Sbjct: 2055 VEAPEAEEEAQEAEGEVQEAEGEAHPESEDV--------DAQEAEGEAQPES-EGVEAPE 2105
Query: 192 APSSTPKAQG---PAASAE---EPKPVEAPAANSD 220
A KA+G P E E + +EAP A +
Sbjct: 2106 AEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGE 2140
Score = 65.9 bits (159), Expect = 3e-11
Identities = 58/215 (26%), Positives = 95/215 (44%), Gaps = 11/215 (5%)
Query: 16 DEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAK-EGK---EKPDQDAEGKAEEKEG 71
D+ K + + + A E EG SE A +E EA+ EG+ E+ + +G E
Sbjct: 1755 DKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNL 1814
Query: 72 EKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAE 131
+ +AAA ++ P + + EG +AE PE E P A G+A +A E A P E
Sbjct: 1815 QGEAAAGGDQDP-GQSDGAEGIEAPEAEGEAQPESE-GVEAPEAEGDAQEA-EGEAQP-E 1870
Query: 132 SAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATE 191
S A E + + E + E P A + +S+GA A +++ EA P ++ A
Sbjct: 1871 SEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAE---KEAQPETESVEALET 1927
Query: 192 APSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVK 226
P+++G A E EA ++ ++
Sbjct: 1928 EGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIE 1962
Score = 65.1 bits (157), Expect = 5e-11
Identities = 67/216 (31%), Positives = 94/216 (43%), Gaps = 26/216 (12%)
Query: 19 AKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAA 78
A+E + +A+ + + E E E Q +E E E + + ++EG AE E EK+A
Sbjct: 1860 AQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEG-AEAPEAEKEA--- 1915
Query: 79 KEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAG 138
+ E E +TEG E ++E +A E E+AA A G P++ + AE A
Sbjct: 1916 QPETESVEALETEGEDEPESEGAEAQEAEEAAQ-EAEGQTQPESEVIESQEAEEEAQPES 1974
Query: 139 E---------EPSKEEG----EPKKTEAPAAPA-AQETKSDGAPASDSKPGSSEAAPSSK 184
E E + EG E + EAP A QE + + P SD EA P S
Sbjct: 1975 EDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESD----GVEAQPKS- 2029
Query: 185 ETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSD 220
E A E T K +G A E VEAP A +
Sbjct: 2030 EGEEAQEVEGETQKTEGDA--QPESDGVEAPEAEEE 2063
Score = 58.5 bits (140), Expect = 4e-09
Identities = 50/173 (28%), Positives = 74/173 (42%), Gaps = 11/173 (6%)
Query: 18 KAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEG-KAEEKEGEKDAA 76
+A E + +A+ + E E E Q +E EA+E +E+ + EG +A E EGE
Sbjct: 2133 EAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPE 2192
Query: 77 AAKEEAPKAEPE---KTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESA 133
+ EAP+AE E + EG +AE PE E P A GEA +E +
Sbjct: 2193 SEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPE-GVETPEAEGEAQPESEGETQGEKKG 2251
Query: 134 APAAG-----EEPSKEEGEPKKTEAPAAPAAQETKSDGA-PASDSKPGSSEAA 180
+P E + E P + P P + + P S + P SS A+
Sbjct: 2252 SPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRAS 2304
Score = 53.1 bits (126), Expect = 2e-07
Identities = 52/186 (27%), Positives = 71/186 (38%), Gaps = 26/186 (13%)
Query: 3 GKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDA 62
G+ + +G D + E ++EG +E E E Q E EA E + + ++
Sbjct: 2139 GEAQPESEGVEAQDAEG-EAQPESEGIEAQEA----EEEAQPELEGVEAPEAEGEAQPES 2193
Query: 63 EG-KAEEKEGEKDAAAAKEEAPKAEPE---KTEGAAEAKAEPPKAPEQEQAAPGPAAGGE 118
EG +A E EGE EAP+AE E + EG +AE PE E G
Sbjct: 2194 EGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQG------ 2247
Query: 119 APKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSE 178
E +P S EE S E P + P P S G +PGS
Sbjct: 2248 -----EKKGSPQVSLGDGQSEEAS-ESSSPVPEDRPTPP-----PSPGGDTPHQRPGSQT 2296
Query: 179 AAPSSK 184
SS+
Sbjct: 2297 GPSSSR 2302
Score = 52.0 bits (123), Expect = 4e-07
Identities = 53/220 (24%), Positives = 87/220 (39%), Gaps = 13/220 (5%)
Query: 1 MGGKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQ 60
MG K+ +++ +++ + +G A E ++P + A+ G
Sbjct: 1676 MGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLS 1735
Query: 61 DAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAP 120
G E ++GE +++ PK + EG A A+ K E +A GEA
Sbjct: 1736 QGPGVDEGEDGEGSQRLNRDKDPKL--GEAEGDAMAQEREGKTHNSETSAGSEL--GEAE 1791
Query: 121 KAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAA 180
+ E + E+ +G E + + EA A +SDGA ++ EA
Sbjct: 1792 QEGEGISERGETGGQGSGHEDNLQ------GEAAAGGDQDPGQSDGAEGIEAPEAEGEAQ 1845
Query: 181 PSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSD 220
P S E A EA +A+G A E + VEAP A +
Sbjct: 1846 PES-EGVEAPEAEGDAQEAEGEA--QPESEDVEAPEAEGE 1882
Score = 52.0 bits (123), Expect = 4e-07
Identities = 47/214 (21%), Positives = 84/214 (39%), Gaps = 17/214 (7%)
Query: 4 KLSKKKKGYNVNDEKAKEKDKKAEGAATE-------EEGTPKESEPQAAAEPAEAKEGKE 56
++ ++K+G + + E A+ K T E G + E EG +
Sbjct: 1691 QILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQ 1750
Query: 57 KPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAG 116
+ ++D + K E EG+ A A+E K +T +E E EQ G +
Sbjct: 1751 RLNRDKDPKLGEAEGD---AMAQEREGKTHNSETSAGSE-------LGEAEQEGEGISER 1800
Query: 117 GEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGS 176
GE + A A G++ + + EAP A + +S+G A +++ +
Sbjct: 1801 GETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDA 1860
Query: 177 SEAAPSSKETPAATEAPSSTPKAQGPAASAEEPK 210
EA ++ EAP + +AQ + E P+
Sbjct: 1861 QEAEGEAQPESEDVEAPEAEGEAQPESEDVETPE 1894
Score = 47.0 bits (110), Expect = 1e-05
Identities = 49/188 (26%), Positives = 78/188 (41%), Gaps = 11/188 (5%)
Query: 16 DEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDA 75
+E E+D + + A++ E E+ Q + E KEG E + + +A + E K
Sbjct: 1272 NEDEAERDSEEQRASSNLEQLA-ENTVQEEVQLEETKEGTE--GEGLQEEAVQLEETKTE 1328
Query: 76 AAAKEEAPKAEPEK-TEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAA 134
+EE + E K TEG E + E E+ + G E + E P
Sbjct: 1329 EGLQEEGVQLEETKETEG--EGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQ 1386
Query: 135 PAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSE----AAPSSKETPA-A 189
A EE KEEG P++ ++ + DG + + P E A+ S++ PA
Sbjct: 1387 GEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEG 1446
Query: 190 TEAPSSTP 197
TE P+ P
Sbjct: 1447 TEEPTEPP 1454
Score = 44.3 bits (103), Expect = 9e-05
Identities = 51/202 (25%), Positives = 76/202 (37%), Gaps = 34/202 (16%)
Query: 21 EKDKKAEGAATEEEGTPKESEPQAAAEP-----AEAKEGKEKPDQDAEGKAEEKEGEKDA 75
E+ K+ EG +EE E + E + +E KE P+ +G+A E EG K+
Sbjct: 1339 EETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALE-EGLKEE 1397
Query: 76 AAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAP 135
+E + + + + K P QE+ A G A +AE P
Sbjct: 1398 GLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEA------GRASASAEPC--------P 1443
Query: 136 AAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSS 195
A G E E EP + P+A E +S S+ P ++ P AT
Sbjct: 1444 AEGTE---EPTEPPSHLSETDPSASERQS-----------GSQLEPGLEKPPGATMMGQE 1489
Query: 196 TPKAQGPAASAEEPKPVEAPAA 217
+AQ +AE V AA
Sbjct: 1490 HTQAQPTQGAAERSSSVACSAA 1511
Score = 42.0 bits (97), Expect = 4e-04
Identities = 47/192 (24%), Positives = 73/192 (38%), Gaps = 31/192 (16%)
Query: 20 KEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAK 79
+E+ + + G P+ SEP+++ P ++G + A+ AE K G
Sbjct: 445 RERCSQDSASPASSTGLPEGSEPESSCCPRTPEDGVDSASPSAQIGAERKAG-------- 496
Query: 80 EEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGE-APKAAEAAAAPAESAAPAAG 138
+ E P GP GG P+A A ++S+A
Sbjct: 497 ---------------GSLGEDPGLCIDGAGLGGPEQGGRLTPRARSEEGASSDSSASTGS 541
Query: 139 EEPSKE-EGEPK--KTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSS 195
E S E G P+ +A A + QE G PAS P S ++ S + A T+
Sbjct: 542 HEGSSEWGGRPQGCPGKARAETSQQEASEGGDPAS---PALSLSSLRSDDLQAETQG-QG 597
Query: 196 TPKAQGPAASAE 207
T +A G A + E
Sbjct: 598 TEQATGAAVTRE 609
Score = 32.3 bits (72), Expect = 0.34
Identities = 36/173 (20%), Positives = 67/173 (38%), Gaps = 21/173 (12%)
Query: 6 SKKKKGYNVNDEKAK-EKDKKAEGAATEEEGTPKESE---PQAAAEPAEAKEGKEKPDQD 61
+K+ +G +E+A+ E+ ++ G +EEG E P+ + +EG ++
Sbjct: 1341 TKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLP 1400
Query: 62 AEGKAEEKE-----------GEKDAAAAKEEAPKA----EPEKTEGAAEAKAEPPKAPEQ 106
EG +E ++D +EEA +A EP EG E P E
Sbjct: 1401 EEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSET 1460
Query: 107 EQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAA 159
+ +A +G + E +P+ +G +++ + A AA
Sbjct: 1461 DPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPT--QGAAERSSSVACSAA 1511
Score = 29.6 bits (65), Expect = 2.2
Identities = 40/183 (21%), Positives = 65/183 (35%), Gaps = 35/183 (19%)
Query: 35 GTPKESEPQAAAEPAE------AKEGKEKPDQDAEGKAEEK--------EGEKDAAAAKE 80
G+P+E Q P+ ++ + G +EEK +G+++A+
Sbjct: 886 GSPQEGTRQPGPTPSPGPNSGASRRSSASQGAGSRGLSEEKTLRSGGGPQGQEEASGVSP 945
Query: 81 EA-PKAEPEKTEGAAEAKAEPPKAP-----EQEQAAPGPAAGG-EAPKAAEAAAAPAESA 133
+ P++ PE E P+ P E G A GG P+ E
Sbjct: 946 SSLPRSSPEAV--VREWLDNIPEEPILMTYELADETTGAAGGGLRGPEVDPGDDHSLEGL 1003
Query: 134 APAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGA--PASDSKPGSSEAAPSSKETPAATE 191
A EG+P Q+ + +GA +SD+ P S E P +E
Sbjct: 1004 GEPAQAGQQSLEGDP----------GQDPEPEGALLGSSDTGPQSGEGVPQGAAPEGVSE 1053
Query: 192 APS 194
AP+
Sbjct: 1054 APA 1056
>gi|153070260 myristoylated alanine-rich protein kinase C substrate
[Homo sapiens]
Length = 332
Score = 75.1 bits (183), Expect = 5e-14
Identities = 80/234 (34%), Positives = 103/234 (44%), Gaps = 47/234 (20%)
Query: 21 EKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEK------PDQDAEGKAEE------ 68
EK+ AEG A E G+P +E +AA+ + K + P + K ++
Sbjct: 104 EKEAPAEGEAAEP-GSPTAAEGEAASAASSTSSPKAEDGATPSPSNETPKKKKKRFSFKK 162
Query: 69 ---------KEGEKDAAAAKE-EAPKAEPEKTE---GAAEAKAEPPKAPEQEQAAPGP-- 113
K+ +K+A E EAP AE K E GAA A AE A ++ AAPG
Sbjct: 163 SFKLSGFSFKKNKKEAGEGGEAEAPAAEGGKDEAAGGAAAAAAEAGAASGEQAAAPGEEA 222
Query: 114 ------AAGGEAPKAAEAAAAPAESAAPA-----AGEEPSKEEGEPKKTEAPAAPAAQET 162
AAGG+ +A AA A PA A EEPSK E E K EA A+ AA E
Sbjct: 223 AAGEEGAAGGDPQEAKPQEAAVAPEKPPASDETKAAEEPSKVE-EKKAEEAGASAAACEA 281
Query: 163 KSDGAPASDSKPGSSEAAPSSKETPAATEAPS--STPKAQGPAASAEEPKPVEA 214
S P + P EAAP+ E PAA A S + P + + E P EA
Sbjct: 282 PSAAGPGA---PPEQEAAPA--EEPAAAAASSACAAPSQEAQPECSPEAPPAEA 330
Score = 68.6 bits (166), Expect = 4e-12
Identities = 79/269 (29%), Positives = 112/269 (41%), Gaps = 51/269 (18%)
Query: 1 MGGKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKES---EPQAAAEPAEAKEGKEK 57
MG + SK E A E+ +A A++ + +E+ + A PA A+ G K
Sbjct: 1 MGAQFSKTA----AKGEAAAERPGEAAVASSPSKANGQENGHVKVNGDASPAAAESGA-K 55
Query: 58 PDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAP-EQEQAAPGPAAG 116
+ A G A + E+ AAA A + EK E AA A E +P E+E A G AA
Sbjct: 56 EELQANGSAPAADKEEPAAAGSGAASPSAAEKGEPAAAAAPEAGASPVEKEAPAEGEAAE 115
Query: 117 GEAPKAAEAAAAPAES--AAPAA--GEEPS------------------------------ 142
+P AAE AA A S ++P A G PS
Sbjct: 116 PGSPTAAEGEAASAASSTSSPKAEDGATPSPSNETPKKKKKRFSFKKSFKLSGFSFKKNK 175
Query: 143 KEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSE----AAPSSKETPAATEAPSSTPK 198
KE GE + EAPAA ++ + GA A+ ++ G++ AAP + A P+
Sbjct: 176 KEAGEGGEAEAPAAEGGKDEAAGGAAAAAAEAGAASGEQAAAPGEEAAAGEEGAAGGDPQ 235
Query: 199 AQGPAASAEEPKPVEAPAANSDQTVTVKE 227
P +A P E P A SD+T +E
Sbjct: 236 EAKPQEAAVAP---EKPPA-SDETKAAEE 260
Score = 65.1 bits (157), Expect = 5e-11
Identities = 64/189 (33%), Positives = 84/189 (44%), Gaps = 28/189 (14%)
Query: 4 KLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAE 63
K S K G++ K KE + E A EG E+ AAA AEA G +Q A
Sbjct: 161 KKSFKLSGFSFKKNK-KEAGEGGEAEAPAAEGGKDEAAGGAAAAAAEA--GAASGEQAAA 217
Query: 64 GKAEEKEGEKDAAA-----AKEEAPKAEPEKTEGAAEAKA--EPPKAPEQE-QAAPGPAA 115
E GE+ AA AK + PEK + E KA EP K E++ + A AA
Sbjct: 218 PGEEAAAGEEGAAGGDPQEAKPQEAAVAPEKPPASDETKAAEEPSKVEEKKAEEAGASAA 277
Query: 116 GGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPG 175
EAP AA A P + AAPA E PAA AA + + AP+ +++P
Sbjct: 278 ACEAPSAAGPGAPPEQEAAPA---------------EEPAAAAA--SSACAAPSQEAQPE 320
Query: 176 SSEAAPSSK 184
S AP ++
Sbjct: 321 CSPEAPPAE 329
Score = 55.1 bits (131), Expect = 5e-08
Identities = 52/161 (32%), Positives = 65/161 (40%), Gaps = 29/161 (18%)
Query: 2 GGKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQD 61
G + + G ++ A ++ A G G P+E++PQ AA
Sbjct: 199 GAAAAAAEAGAASGEQAAAPGEEAAAGEEGAAGGDPQEAKPQEAA--------------- 243
Query: 62 AEGKAEEKEGEKDAAAAKEEAPKAEPEKTE--GAAEAKAEPPKAPEQEQAAPGPAAGGEA 119
A EK D A EE K E +K E GA+ A E P A A PG EA
Sbjct: 244 ---VAPEKPPASDETKAAEEPSKVEEKKAEEAGASAAACEAPSA-----AGPGAPPEQEA 295
Query: 120 PKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQ 160
A E AAA A SA A PS+E EAP A AA+
Sbjct: 296 APAEEPAAAAASSACAA----PSQEAQPECSPEAPPAEAAE 332
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 74.7 bits (182), Expect = 6e-14
Identities = 64/258 (24%), Positives = 111/258 (43%), Gaps = 40/258 (15%)
Query: 8 KKKGYNVNDEKAKEKDKKAEGAATEEEGTPKES----EPQAAAEPAEAKEGKEKPDQDAE 63
KKK + + E + E++++ +G ++ P + +AAA+ +E+ +E D D E
Sbjct: 79 KKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDE 138
Query: 64 GKAEEKEGEK----DAAAAKEEAPKAEPEKTEGAAEAKAEPPK----------APEQEQA 109
+++ +K A AAK KA+ ++ + ++ EPPK Q +A
Sbjct: 139 EDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKA 198
Query: 110 APGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEE----GEPKKT--------EAPAAP 157
P PA APK A AA + S++ ++ EE PKKT +AP
Sbjct: 199 PPKPARA--APKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKA 256
Query: 158 AAQETKSDGAPASDS--------KPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEP 209
A T+ + S KP ++ P S P + P + Q P + E+
Sbjct: 257 ATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQ 316
Query: 210 KPVEAPAANSDQTVTVKE 227
+PVE+ +SD++ + E
Sbjct: 317 QPVESSEDSSDESDSSSE 334
Score = 60.5 bits (145), Expect = 1e-09
Identities = 58/218 (26%), Positives = 84/218 (38%), Gaps = 35/218 (16%)
Query: 18 KAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAE--------EK 69
+A K + A++ + S + E A A K P + KA K
Sbjct: 204 RAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRK 263
Query: 70 EGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAP 129
+ +++ EE + +P K + + PP AP P + G + PK A P
Sbjct: 264 SSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPP-----PKKSLGTQPPKKAVEKQQP 318
Query: 130 AESAAPAAGEEPSKEEGEPK----------KTEAPAAPAAQETKSDGAPASDSKPGSSEA 179
ES+ ++ E S E E K T+ P A A E+ SD +SDS +
Sbjct: 319 VESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSD---SSDSDSSEDDE 375
Query: 180 APSSKETPAATEAPSSTPKAQGPAASAEEP--KPVEAP 215
APS PA T SS PA + + P KP AP
Sbjct: 376 APSK---PAGTTKNSSNK----PAVTTKSPAVKPAAAP 406
Score = 57.4 bits (137), Expect = 1e-08
Identities = 56/203 (27%), Positives = 82/203 (40%), Gaps = 30/203 (14%)
Query: 48 PAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPE-- 105
P K K+ D+E +EE+E + A K P G A AKA + E
Sbjct: 73 PVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEES 132
Query: 106 -----QEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKK---------- 150
+E P G P+ A+AA AP + A + + S E EP K
Sbjct: 133 SDDDDEEDQKKQPVQKGVKPQ-AKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVT 191
Query: 151 ----TEAPAAP--AAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPK----AQ 200
T+AP P AA + + A +S S SS ++ S+E AA + PK A+
Sbjct: 192 VKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAK 251
Query: 201 GPAASAEEP--KPVEAPAANSDQ 221
P +A P K + ++SD+
Sbjct: 252 APVKAATTPTRKSSSSEDSSSDE 274
Score = 55.5 bits (132), Expect = 4e-08
Identities = 60/225 (26%), Positives = 98/225 (43%), Gaps = 39/225 (17%)
Query: 11 GYNVNDEKAKEKDKKAEGAATEEEGTPK---ESEPQAAAEPA------EAKEGKEKPDQD 61
G + KA + E +++EEE T K ++P+A A+ A +A +G D
Sbjct: 413 GQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSD 472
Query: 62 AEGKAEEKEGEKDAAAAKEEAPK-----AEPEKTEGAAEAKAEPPKAP-------EQEQA 109
++ + E+E EK + +A ++ P+ A P K A + KAE + E+E+
Sbjct: 473 SDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEK 532
Query: 110 APGPAAGG-EAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAP 168
G + +APKA +A A++ A + S+EE E KK A + K
Sbjct: 533 LKGKGSPRPQAPKANGTSALTAQNGKAA---KNSEEEEEEKKKAAVVVSKSGSLK----- 584
Query: 169 ASDSKPGSSEAAPSSKETPAA----TEAPSSTPKAQGPAASAEEP 209
K +EAA + ETP A + P++ PK + A P
Sbjct: 585 ----KRKQNEAAKEA-ETPQAKKIKLQTPNTFPKRKKGEKRASSP 624
Score = 51.6 bits (122), Expect = 5e-07
Identities = 56/248 (22%), Positives = 100/248 (40%), Gaps = 40/248 (16%)
Query: 17 EKAKEKDKKAEGA--ATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKD 74
+KA EK + E + +++E + E E + + +K + P ++ + D
Sbjct: 310 KKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSD 369
Query: 75 AAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPG--PAAGGEAPKAAEAAAAPAES 132
++ +EAP T+ ++ A K+P + AA P GG+ +A ++ +E
Sbjct: 370 SSE-DDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEE 428
Query: 133 AAPAAGEEPSKEEGEPKKTEAPAA-----PAAQETKSDGAPASDSKPGSSE--------- 178
+ ++ EE +K+ K +A A PA Q + +SDS SSE
Sbjct: 429 ESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKS 488
Query: 179 ------------AAPSSKETPAATEAPSSTPKAQGPAASAEE--------PKPVEAPAAN 218
AAPS + +A SS + ++ EE P+P +AP AN
Sbjct: 489 AVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRP-QAPKAN 547
Query: 219 SDQTVTVK 226
+T +
Sbjct: 548 GTSALTAQ 555
Score = 49.3 bits (116), Expect = 3e-06
Identities = 43/169 (25%), Positives = 72/169 (42%), Gaps = 21/169 (12%)
Query: 65 KAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAE 124
K E++ + + AK+ KA +E ++E +E+ GP A A A
Sbjct: 62 KVPERKLQANGPVAKKAKKKASSSDSEDSSE----------EEEEVQGPPAKKAAVPAKR 111
Query: 125 AAAAPAESAAPA----AGEEPSKEEGEPKKTEAPAAPAAQ-ETKSDGAPASDSKPGSSEA 179
P ++AA A + EE S ++ E + + P + + K+ AP +K S++
Sbjct: 112 VGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDS 171
Query: 180 APSSKETPAATEAPSSTP---KAQ---GPAASAEEPKPVEAPAANSDQT 222
SS++ P + P TP KAQ P + PK AA+S +
Sbjct: 172 DSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSS 220
Score = 49.3 bits (116), Expect = 3e-06
Identities = 53/247 (21%), Positives = 102/247 (41%), Gaps = 43/247 (17%)
Query: 9 KKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQ-AAAEPAEAKEGKEKPDQDAEGKAE 67
KK + + + + + A ++ GT K S + A + A + P Q G +
Sbjct: 356 KKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQK 415
Query: 68 EKEGEKDAAAAKEEAPKAEPEKT-------------------------EGAAEAKAEPPK 102
+ D+++++EE+ +E EKT +G+ ++ ++
Sbjct: 416 LLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDS 475
Query: 103 APEQEQ----------AAPGPAAGGEAP-KAAEAAAAPAESAAPAAGEEPSKEEGEPKKT 151
+ +E+ P AGG AP K A A AES+ ++ ++ S+EE E K
Sbjct: 476 SSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEE--KL 533
Query: 152 EAPAAPAAQETKSDGAPASDSKPG----SSEAAPSSKETPAATEAPSSTPKAQGPAASAE 207
+ +P Q K++G A ++ G +SE K+ A + S + K + +A+
Sbjct: 534 KGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAK 593
Query: 208 EPKPVEA 214
E + +A
Sbjct: 594 EAETPQA 600
Score = 47.8 bits (112), Expect = 8e-06
Identities = 46/218 (21%), Positives = 76/218 (34%), Gaps = 32/218 (14%)
Query: 37 PKES----EPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEG 92
PK+S P+ A E + E E +++ +EE++ A + K P K
Sbjct: 300 PKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAA 359
Query: 93 AAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAG-------------- 138
+ + + + E ++A PA + A + + PAA
Sbjct: 360 ESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTR 419
Query: 139 ---------EEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEA-----APSSK 184
E S EE + KK A P A + PA + GS ++ + SS+
Sbjct: 420 KADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSE 479
Query: 185 ETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQT 222
E T + K Q A A KP A ++ +
Sbjct: 480 EEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESS 517
Score = 34.7 bits (78), Expect = 0.069
Identities = 30/111 (27%), Positives = 54/111 (48%), Gaps = 16/111 (14%)
Query: 6 SKKKKGYNVN----DEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPA-EAKEGKEKPDQ 60
+KK K + N D+ ++E+++K +G +G+P+ P+A A A+ GK
Sbjct: 509 AKKGKAESSNSSSSDDSSEEEEEKLKG-----KGSPRPQAPKANGTSALTAQNGK----- 558
Query: 61 DAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAP 111
A +EE+E EK AA + ++ + A +AE P+A + + P
Sbjct: 559 -AAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTP 608
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 73.9 bits (180), Expect = 1e-13
Identities = 63/206 (30%), Positives = 94/206 (45%), Gaps = 12/206 (5%)
Query: 18 KAKEKDKKAEGAATEEEGTP-KESEP----QAAAEPAEAKEGKEKPDQDAEGKAEE-KEG 71
KA EK + A+ +GTP K + P +A A ++ K GK P++D+E +EE +
Sbjct: 215 KASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGK--PEEDSESSSEESSDS 272
Query: 72 EKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAE 131
E++ AAK KT A A P K ++ AAP P G P A+A A E
Sbjct: 273 EEETPAAKALLQAKASGKTSQVGAASA-PAKESPRKGAAPAP-PGKTGPAVAKAQAGKRE 330
Query: 132 SAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATE 191
+ ++ EE EE P +A + A + ++ APA +S + AP K PAA +
Sbjct: 331 EDSQSSSEESDSEEEAP--AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 388
Query: 192 APSSTPKAQGPAASAEEPKPVEAPAA 217
+ ++S E EA AA
Sbjct: 389 VQVGKQEEDSRSSSEESDSDREALAA 414
Score = 63.9 bits (154), Expect = 1e-10
Identities = 57/206 (27%), Positives = 80/206 (38%), Gaps = 21/206 (10%)
Query: 20 KEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAK 79
K K AE +A + E E A A AK G Q A+ +E+ D +
Sbjct: 155 KSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQ-ADSSSEDTSSSSDETDVE 213
Query: 80 EEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGE 139
+A + + +A AK P K A P P P A A A+ ++ P
Sbjct: 214 VKASEKILQVRAASAPAKGTPGKG-----ATPAP------PGKAGAVASQTKAGKPEEDS 262
Query: 140 EPSKEEGEPKKTEAPAAPAAQETKSDG---------APASDSKPGSSEAAPSSKETPAAT 190
E S EE + E PAA A + K+ G APA +S + AP K PA
Sbjct: 263 ESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVA 322
Query: 191 EAPSSTPKAQGPAASAEEPKPVEAPA 216
+A + + ++S E EAPA
Sbjct: 323 KAQAGKREEDSQSSSEESDSEEEAPA 348
Score = 60.8 bits (146), Expect = 9e-10
Identities = 59/220 (26%), Positives = 90/220 (40%), Gaps = 25/220 (11%)
Query: 9 KKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEE 68
K G V KA +K+ + ++EEE +E AAA PA+ K +K A A
Sbjct: 669 KTGPTVTQVKA---EKQEDSESSEEESDSEE----AAASPAQVKTSVKKTQAKANPAAAR 721
Query: 69 KEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQA-APGPAA----GGEAPKAA 123
K +A + A + + + P + P+ A GPA+ G AA
Sbjct: 722 APSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAA 781
Query: 124 EAAAAPAESAAPAAGEEPSKEE----------GEPKKTEAPAAPAAQETKSDGAPASDSK 173
+A P E + + E S+EE G+ + A APA + + AP K
Sbjct: 782 QAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGK 841
Query: 174 PGSSEAAPSSKETPAATEAPSSTPKAQGPAA--SAEEPKP 211
G S AA + K+ + + + S + PAA SA+ KP
Sbjct: 842 TGPS-AAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKP 880
Score = 54.3 bits (129), Expect = 8e-08
Identities = 61/208 (29%), Positives = 91/208 (43%), Gaps = 34/208 (16%)
Query: 2 GGKLSKKKKGYNVNDEKAK-------EKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEG 54
G S+ K G D ++ E++ A A + + + K S+ AA+ PA
Sbjct: 247 GAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPA----- 301
Query: 55 KEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPA 114
KE P +G A G+ A AK +A K E + + E+ +E E+A
Sbjct: 302 KESP---RKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE-------EEAPAQAK 351
Query: 115 AGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKP 174
G+AP+ AA+APA+ +P G P+ P+KT PAA Q K + DS+
Sbjct: 352 PSGKAPQ-VRAASAPAKE-SPRKGAAPA----PPRKT-GPAAAQVQVGKQE----EDSR- 399
Query: 175 GSSEAAPSSKETPAATEAPSSTPKAQGP 202
SSE + S +E AA A P + P
Sbjct: 400 SSSEESDSDREALAAMNAAQVKPLGKSP 427
Score = 50.1 bits (118), Expect = 2e-06
Identities = 59/238 (24%), Positives = 90/238 (37%), Gaps = 44/238 (18%)
Query: 18 KAKEKDKKAEGAATEEEGTPKESE---PQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKD 74
KA K + A+ + +P++ P PA AK K ++D++ +EE + E++
Sbjct: 286 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEE 345
Query: 75 AAAAKEEAPKAEPEKTEGAAEAKAEPPK-APEQEQAAPGPAAGG---------------E 118
A A + + KA P+ +A AK P K A GPAA E
Sbjct: 346 APAQAKPSGKA-PQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEE 404
Query: 119 APKAAEAAAAPAESAAPAAGEEPSKEEGE--------------PKKTEAPAAPAAQETKS 164
+ EA AA + G+ P + P PA P+AQ K
Sbjct: 405 SDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKW 464
Query: 165 DGAPASDSKPGSSEAAPSSK-ETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQ 221
+ DS+ S E++ SS E P A P + + + KP +PA Q
Sbjct: 465 E----EDSESSSEESSDSSDGEVPTAV-----APAQEKSLGNILQAKPTSSPAKGPPQ 513
Score = 48.9 bits (115), Expect = 4e-06
Identities = 52/225 (23%), Positives = 89/225 (39%), Gaps = 30/225 (13%)
Query: 22 KDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEE 81
+ +KAE A + + S+P + +E +E +E E KA + +++ +
Sbjct: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAET----AKATPRLASTNSSVLGAD 116
Query: 82 APKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGE-- 139
P + EK AKAE KA + + P PA G + +P +SA P+A
Sbjct: 117 LPSSMKEK------AKAETEKAGKTGNSMPHPATGKTVANLL-SGKSPRKSAEPSANTTL 169
Query: 140 -EPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSE----------------AAPS 182
++EEG A A P + + D+ S E A+
Sbjct: 170 VSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAP 229
Query: 183 SKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
+K TP P+ KA A+ + KP E ++S+++ +E
Sbjct: 230 AKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEE 274
Score = 48.1 bits (113), Expect = 6e-06
Identities = 52/210 (24%), Positives = 83/210 (39%), Gaps = 23/210 (10%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEG--EKDAAAAKEEA----------P 83
+P + PQ A P + EKP ++E E + ++A AA A
Sbjct: 506 SPAKGPPQKAG-PVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQT 564
Query: 84 KAEPEKTEGAAEAKAEP----PKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGE 139
KA P+KT A AK P +AP + A PA G +P A PAE ++ +
Sbjct: 565 KACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA--GSSPAVAGGTQRPAEDSSSSEES 622
Query: 140 EPSKEEGEPKKT--EAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTP 197
+ +E+ T +A + + K+ P S + K P T+ +
Sbjct: 623 DSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAE-- 680
Query: 198 KAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
K + +S EE EA A+ + +VK+
Sbjct: 681 KQEDSESSEEESDSEEAAASPAQVKTSVKK 710
Score = 47.4 bits (111), Expect = 1e-05
Identities = 57/252 (22%), Positives = 96/252 (38%), Gaps = 50/252 (19%)
Query: 2 GGKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEK---- 57
G ++K + G D ++ ++ +E A + P PQ A A AKE K
Sbjct: 318 GPAVAKAQAGKREEDSQSSSEESDSEEEAPAQ-AKPSGKAPQVRAASAPAKESPRKGAAP 376
Query: 58 -----------------PDQDAEGKAEEKEGEKDAAAAKEEA--------PKAEPEKTEG 92
++D+ +EE + +++A AA A P+ +P T G
Sbjct: 377 APPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMG 436
Query: 93 AAE-AKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS-------KE 144
K P P + A A G+ + +E+++ ES+ + GE P+ K
Sbjct: 437 MGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE--ESSDSSDGEVPTAVAPAQEKS 494
Query: 145 EG---EPKKTEAPA-------APAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPS 194
G + K T +PA P A + K++ + S + S+E PAA A
Sbjct: 495 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQ 554
Query: 195 STPKAQGPAASA 206
+ P + P A
Sbjct: 555 AKPALKIPQTKA 566
Score = 47.4 bits (111), Expect = 1e-05
Identities = 49/187 (26%), Positives = 85/187 (45%), Gaps = 18/187 (9%)
Query: 44 AAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKA 103
A + PA A G ++P +D+ +EE + E++ +A+ +A + P K
Sbjct: 599 AGSSPAVAG-GTQRPAEDSSS-SEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG 656
Query: 104 PEQEQAAP------GPAAGG-EAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAA 156
+ AP GP +A K ++ ++ ES + A P++ + KKT+A A
Sbjct: 657 SLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKAN 716
Query: 157 PAAQETKSDGAPASDSKPGS--SEAAPSSKETPAATEAP-----SSTPKAQGPAASAEEP 209
PAA ++ A + S PG + AA + + +P+ + P +ST A+GPA+
Sbjct: 717 PAA--ARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVG 774
Query: 210 KPVEAPA 216
K V A
Sbjct: 775 KAVATAA 781
Score = 45.4 bits (106), Expect = 4e-05
Identities = 42/174 (24%), Positives = 65/174 (37%), Gaps = 18/174 (10%)
Query: 58 PDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEK--------TEGAAEAKAEPPKAPEQEQA 109
P G + KE + + K+E P + K T+ A + A+ + A
Sbjct: 956 PKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVA 1015
Query: 110 APGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPA 169
P++G ++ A +P ++ A G ++ PK E A A E+ D +
Sbjct: 1016 RTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRK---PKLPEVQQATKAPESSDDSEDS 1072
Query: 170 SDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTV 223
SDS GS E E P + S GP S E E A +S+ V
Sbjct: 1073 SDSSSGSEE----DGEGP---QGAKSAHTLVGPTPSRTETLVEETAAESSEDDV 1119
Score = 40.0 bits (92), Expect = 0.002
Identities = 46/215 (21%), Positives = 92/215 (42%), Gaps = 13/215 (6%)
Query: 15 NDEKAKEKDKKAEGAAT--EEEGTPKESEPQAAAEPAEAKEGKEK----PDQDAEGKAEE 68
+ E++ +++K A T + + K + +AA+ P + G+ P + +
Sbjct: 618 SSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQV 677
Query: 69 K-EGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGG--EAPKAAEA 125
K E ++D+ +++EE+ E + + + +A AA P+A G AP
Sbjct: 678 KAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVT 737
Query: 126 AAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDG-APASDSKPGSSEAAPSSK 184
AAA A+ +P+ + P + T PA+ + A A+ ++ G E + SS+
Sbjct: 738 AAAQAKQRSPSKVKPPVR--NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSE 795
Query: 185 ETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANS 219
E + E + + + P+ + + APA S
Sbjct: 796 EESDSEEEAETLAQVK-PSGKTHQIRAALAPAKES 829
Score = 39.7 bits (91), Expect = 0.002
Identities = 46/187 (24%), Positives = 71/187 (37%), Gaps = 21/187 (11%)
Query: 27 EGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAE 86
+ T + PK E Q A + E+ + E + G E+ EG + A +A
Sbjct: 1041 QAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPT- 1099
Query: 87 PEKTEGAAEAKAEPPKAPEQEQAAPGPA--AGGEAPKAAEAAAAPAESAAPAAGEEPSKE 144
P +TE E A ++ E + AP + +G P PA S A A
Sbjct: 1100 PSRTETLVEETAA--ESSEDDVVAPSQSLLSGYMTP-----GLTPANSQASKA------- 1145
Query: 145 EGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTP-KAQGPA 203
PK +P+ + K D ++KP A S +T A +TP K++ P
Sbjct: 1146 --TPKLDSSPSVSSTLAAKDDPDGKQEAKP-QQAAGMLSPKTGGKEAASGTTPQKSRKPK 1202
Query: 204 ASAEEPK 210
A P+
Sbjct: 1203 KGAGNPQ 1209
Score = 33.5 bits (75), Expect = 0.15
Identities = 16/47 (34%), Positives = 27/47 (57%)
Query: 4 KLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAE 50
K KKK D++ KEK KKA+ A+T++ +P + + + + AE
Sbjct: 1363 KKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAE 1409
Score = 33.1 bits (74), Expect = 0.20
Identities = 41/186 (22%), Positives = 71/186 (38%), Gaps = 10/186 (5%)
Query: 23 DKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEA 82
+ +A A + + +P S AA + + K+ E Q A G K G K+AA+
Sbjct: 1139 NSQASKATPKLDSSPSVSSTLAAKDDPDGKQ--EAKPQQAAGMLSPKTGGKEAASGTTPQ 1196
Query: 83 PKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAE------SAAPA 136
+P+K G +A ++ + P EA A E
Sbjct: 1197 KSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVD 1256
Query: 137 AGEEPSKEEGEPKKTEAPA-APAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSS 195
+E S++ E +K + PAA+ +S + G EA+ S ++T ++ +
Sbjct: 1257 TTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEG-GEASVSPEKTSTTSKGKAK 1315
Query: 196 TPKAQG 201
KA G
Sbjct: 1316 RDKASG 1321
Score = 33.1 bits (74), Expect = 0.20
Identities = 34/146 (23%), Positives = 55/146 (37%), Gaps = 6/146 (4%)
Query: 50 EAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQA 109
E+++ K DQ A K+ +K A EA PEKT ++ KA+ KA +
Sbjct: 1267 ESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEA-SVSPEKTSTTSKGKAKRDKASGDVKE 1325
Query: 110 APGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS-----KEEGEPKKTEAPAAPAAQETKS 164
G + G E + G + S KE+ + K + ++ K+
Sbjct: 1326 KKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKA 1385
Query: 165 DGAPASDSKPGSSEAAPSSKETPAAT 190
A DS+ S + K+T T
Sbjct: 1386 KKASTKDSESPSQKKKKKKKKTAEQT 1411
Score = 31.2 bits (69), Expect = 0.76
Identities = 27/106 (25%), Positives = 47/106 (44%), Gaps = 8/106 (7%)
Query: 3 GKLSKKKKGYNVNDEKAKEKDKKAEGAATE-EEGTPKESEPQAAAEPAEAKEGKEKPDQD 61
GK + K +V ++K K ++GA E EE K + + K KEK D
Sbjct: 1312 GKAKRDKASGDVKEKKGKGS-LGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSD 1370
Query: 62 AEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQE 107
K +EK+ + K++A KA + +E ++ K + K ++
Sbjct: 1371 KRKKDKEKKEK------KKKAKKASTKDSESPSQKKKKKKKKTAEQ 1410
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 73.9 bits (180), Expect = 1e-13
Identities = 63/206 (30%), Positives = 94/206 (45%), Gaps = 12/206 (5%)
Query: 18 KAKEKDKKAEGAATEEEGTP-KESEP----QAAAEPAEAKEGKEKPDQDAEGKAEE-KEG 71
KA EK + A+ +GTP K + P +A A ++ K GK P++D+E +EE +
Sbjct: 292 KASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGK--PEEDSESSSEESSDS 349
Query: 72 EKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAE 131
E++ AAK KT A A P K ++ AAP P G P A+A A E
Sbjct: 350 EEETPAAKALLQAKASGKTSQVGAASA-PAKESPRKGAAPAP-PGKTGPAVAKAQAGKRE 407
Query: 132 SAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATE 191
+ ++ EE EE P +A + A + ++ APA +S + AP K PAA +
Sbjct: 408 EDSQSSSEESDSEEEAP--AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 465
Query: 192 APSSTPKAQGPAASAEEPKPVEAPAA 217
+ ++S E EA AA
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAA 491
Score = 72.0 bits (175), Expect = 4e-13
Identities = 62/228 (27%), Positives = 90/228 (39%), Gaps = 30/228 (13%)
Query: 19 AKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKA----EEKEGEKD 74
+ +D + T+ EG P Q A KE + A GK + +G
Sbjct: 198 SSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGAL 257
Query: 75 AAAAKEEAPKAEPEKTEGAAEAKAEPP-------KAPE---QEQAAPGPAAGGEA----- 119
A + + P+ E E +E +E++ E P KA E Q +AA PA G
Sbjct: 258 PPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATP 317
Query: 120 --PKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDG---------AP 168
P A A A+ ++ P E S EE + E PAA A + K+ G AP
Sbjct: 318 APPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAP 377
Query: 169 ASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPA 216
A +S + AP K PA +A + + ++S E EAPA
Sbjct: 378 AKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPA 425
Score = 62.4 bits (150), Expect = 3e-10
Identities = 70/242 (28%), Positives = 96/242 (39%), Gaps = 52/242 (21%)
Query: 20 KEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAK 79
K K AE +A + E E A A AK G Q A+ +E+ D
Sbjct: 155 KSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQ-ADSSSEDTSSSSDETDV- 212
Query: 80 EEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEA-PKAAEAAAAPAESAAPAAG 138
E P +P + + ++ + E P +AAP P G+ P+ A PA+ A
Sbjct: 213 EGKPSVKPAQVKASSVSTKESPA----RKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEE 268
Query: 139 EEPSKEEGEPKKTEAPA-------------------APA-------------------AQ 160
E S EEG + EAPA APA A
Sbjct: 269 ESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVAS 328
Query: 161 ETKSDGAPASDSKPGSSEAAPSSKETPAA---TEAPSSTPKAQGPAASA---EEPKPVEA 214
+TK+ G P DS+ S E++ S +ETPAA +A +S +Q AASA E P+ A
Sbjct: 329 QTKA-GKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387
Query: 215 PA 216
PA
Sbjct: 388 PA 389
Score = 60.8 bits (146), Expect = 9e-10
Identities = 59/220 (26%), Positives = 90/220 (40%), Gaps = 25/220 (11%)
Query: 9 KKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEE 68
K G V KA +K+ + ++EEE +E AAA PA+ K +K A A
Sbjct: 746 KTGPTVTQVKA---EKQEDSESSEEESDSEE----AAASPAQVKTSVKKTQAKANPAAAR 798
Query: 69 KEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQA-APGPAA----GGEAPKAA 123
K +A + A + + + P + P+ A GPA+ G AA
Sbjct: 799 APSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAA 858
Query: 124 EAAAAPAESAAPAAGEEPSKEE----------GEPKKTEAPAAPAAQETKSDGAPASDSK 173
+A P E + + E S+EE G+ + A APA + + AP K
Sbjct: 859 QAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGK 918
Query: 174 PGSSEAAPSSKETPAATEAPSSTPKAQGPAA--SAEEPKP 211
G S AA + K+ + + + S + PAA SA+ KP
Sbjct: 919 TGPS-AAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKP 957
Score = 54.3 bits (129), Expect = 8e-08
Identities = 61/208 (29%), Positives = 91/208 (43%), Gaps = 34/208 (16%)
Query: 2 GGKLSKKKKGYNVNDEKAK-------EKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEG 54
G S+ K G D ++ E++ A A + + + K S+ AA+ PA
Sbjct: 324 GAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPA----- 378
Query: 55 KEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPA 114
KE P +G A G+ A AK +A K E + + E+ +E E+A
Sbjct: 379 KESP---RKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE-------EEAPAQAK 428
Query: 115 AGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKP 174
G+AP+ AA+APA+ +P G P+ P+KT PAA Q K + DS+
Sbjct: 429 PSGKAPQ-VRAASAPAKE-SPRKGAAPA----PPRKT-GPAAAQVQVGKQE----EDSR- 476
Query: 175 GSSEAAPSSKETPAATEAPSSTPKAQGP 202
SSE + S +E AA A P + P
Sbjct: 477 SSSEESDSDREALAAMNAAQVKPLGKSP 504
Score = 50.1 bits (118), Expect = 2e-06
Identities = 59/238 (24%), Positives = 90/238 (37%), Gaps = 44/238 (18%)
Query: 18 KAKEKDKKAEGAATEEEGTPKESE---PQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKD 74
KA K + A+ + +P++ P PA AK K ++D++ +EE + E++
Sbjct: 363 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEE 422
Query: 75 AAAAKEEAPKAEPEKTEGAAEAKAEPPK-APEQEQAAPGPAAGG---------------E 118
A A + + KA P+ +A AK P K A GPAA E
Sbjct: 423 APAQAKPSGKA-PQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEE 481
Query: 119 APKAAEAAAAPAESAAPAAGEEPSKEEGE--------------PKKTEAPAAPAAQETKS 164
+ EA AA + G+ P + P PA P+AQ K
Sbjct: 482 SDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKW 541
Query: 165 DGAPASDSKPGSSEAAPSSK-ETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQ 221
+ DS+ S E++ SS E P A P + + + KP +PA Q
Sbjct: 542 E----EDSESSSEESSDSSDGEVPTAV-----APAQEKSLGNILQAKPTSSPAKGPPQ 590
Score = 48.5 bits (114), Expect = 5e-06
Identities = 45/191 (23%), Positives = 76/191 (39%), Gaps = 26/191 (13%)
Query: 58 PDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEA--------------KAEPPKA 103
P G + KE + + K+E P + + G A K PK
Sbjct: 1033 PKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKL 1092
Query: 104 PEQEQAAPGPAAGGEAPKAAEAAAAP---------AESAAPAAGEEPSKEEGEPKKTEAP 154
PE +QA P + ++ ++++++ A+SA G PS+ E ++T A
Sbjct: 1093 PEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAE 1152
Query: 155 AAPAAQETKSDGAPASDSKPGSSEA-APSSKETPAATEAP--SSTPKAQGPAASAEEPKP 211
++ S + PG + A + +SK TP +P SST A+ +E KP
Sbjct: 1153 SSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKP 1212
Query: 212 VEAPAANSDQT 222
+A S +T
Sbjct: 1213 QQAAGMLSPKT 1223
Score = 48.1 bits (113), Expect = 6e-06
Identities = 52/210 (24%), Positives = 83/210 (39%), Gaps = 23/210 (10%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEG--EKDAAAAKEEA----------P 83
+P + PQ A P + EKP ++E E + ++A AA A
Sbjct: 583 SPAKGPPQKAG-PVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQT 641
Query: 84 KAEPEKTEGAAEAKAEP----PKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGE 139
KA P+KT A AK P +AP + A PA G +P A PAE ++ +
Sbjct: 642 KACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA--GSSPAVAGGTQRPAEDSSSSEES 699
Query: 140 EPSKEEGEPKKT--EAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTP 197
+ +E+ T +A + + K+ P S + K P T+ +
Sbjct: 700 DSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAE-- 757
Query: 198 KAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
K + +S EE EA A+ + +VK+
Sbjct: 758 KQEDSESSEEESDSEEAAASPAQVKTSVKK 787
Score = 47.4 bits (111), Expect = 1e-05
Identities = 57/252 (22%), Positives = 96/252 (38%), Gaps = 50/252 (19%)
Query: 2 GGKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEK---- 57
G ++K + G D ++ ++ +E A + P PQ A A AKE K
Sbjct: 395 GPAVAKAQAGKREEDSQSSSEESDSEEEAPAQ-AKPSGKAPQVRAASAPAKESPRKGAAP 453
Query: 58 -----------------PDQDAEGKAEEKEGEKDAAAAKEEA--------PKAEPEKTEG 92
++D+ +EE + +++A AA A P+ +P T G
Sbjct: 454 APPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMG 513
Query: 93 AAE-AKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS-------KE 144
K P P + A A G+ + +E+++ ES+ + GE P+ K
Sbjct: 514 MGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE--ESSDSSDGEVPTAVAPAQEKS 571
Query: 145 EG---EPKKTEAPA-------APAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPS 194
G + K T +PA P A + K++ + S + S+E PAA A
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQ 631
Query: 195 STPKAQGPAASA 206
+ P + P A
Sbjct: 632 AKPALKIPQTKA 643
Score = 47.4 bits (111), Expect = 1e-05
Identities = 49/187 (26%), Positives = 85/187 (45%), Gaps = 18/187 (9%)
Query: 44 AAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKA 103
A + PA A G ++P +D+ +EE + E++ +A+ +A + P K
Sbjct: 676 AGSSPAVAG-GTQRPAEDSSS-SEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG 733
Query: 104 PEQEQAAP------GPAAGG-EAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAA 156
+ AP GP +A K ++ ++ ES + A P++ + KKT+A A
Sbjct: 734 SLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKAN 793
Query: 157 PAAQETKSDGAPASDSKPGS--SEAAPSSKETPAATEAP-----SSTPKAQGPAASAEEP 209
PAA ++ A + S PG + AA + + +P+ + P +ST A+GPA+
Sbjct: 794 PAA--ARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVG 851
Query: 210 KPVEAPA 216
K V A
Sbjct: 852 KAVATAA 858
Score = 45.1 bits (105), Expect = 5e-05
Identities = 44/211 (20%), Positives = 78/211 (36%), Gaps = 5/211 (2%)
Query: 14 VNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEG-KEKPDQDAEGKAEEKEGE 72
++ ++ E++++AE A + TP+ + ++ A+ KEK + E +
Sbjct: 82 ISTSESSEEEEEAE--AETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSM 139
Query: 73 KDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEA-PKAAEAAAAPAE 131
A K A + +AE A E E+ PA G A P A A +
Sbjct: 140 PHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSS 199
Query: 132 SAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGS-SEAAPSSKETPAAT 190
S ++ + + EG+P A ++ TK A + PG + P K
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPP 259
Query: 191 EAPSSTPKAQGPAASAEEPKPVEAPAANSDQ 221
+ P+ + ++ EAPA Q
Sbjct: 260 AKRAKKPEEESESSEEGSESEEEAPAGTRSQ 290
Score = 44.3 bits (103), Expect = 9e-05
Identities = 57/224 (25%), Positives = 90/224 (40%), Gaps = 52/224 (23%)
Query: 22 KDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEE 81
+ +KAE A + + S+P + +E +E +E E KA + +++ +
Sbjct: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAET----AKATPRLASTNSSVLGAD 116
Query: 82 APKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEP 141
P + EK AKAE KA + + P PA G + A +P EP
Sbjct: 117 LPSSMKEK------AKAETEKAGKTGNSMPHPATG-------KTVANLLSGKSPRKSAEP 163
Query: 142 S---------KEEGEPKKTEAPAAPA------AQETKSDGAPASDS---------KPGSS 177
S +EEG A A P A + D + +SD KP
Sbjct: 164 SANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQV 223
Query: 178 EAAP-SSKETPAATEAPSS------TPKAQG----PAASAEEPK 210
+A+ S+KE+PA AP+ TP+ +G PA A++P+
Sbjct: 224 KASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPE 267
Score = 41.2 bits (95), Expect = 7e-04
Identities = 46/211 (21%), Positives = 80/211 (37%), Gaps = 12/211 (5%)
Query: 11 GYNVNDEKAKEKD-KKAEGAATEEE---GTPKESEPQAAAEPAEAKEGKEKP---DQDAE 63
G + + E ++ D KK EG AT+ + GT + PQ+ + A+ KP +
Sbjct: 1039 GASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQA 1098
Query: 64 GKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAA 123
KA E + + ++ + + E +GA A P + + A +
Sbjct: 1099 TKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDV 1158
Query: 124 EAAAAPAESAAPAAGEEPSKEEGE---PKKTEAPAAPAAQETKSDGAPASDSKPGSSEAA 180
A + S G P+ + PK +P+ + K D ++KP A
Sbjct: 1159 VAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKP-QQAAG 1217
Query: 181 PSSKETPAATEAPSSTP-KAQGPAASAEEPK 210
S +T A +TP K++ P A P+
Sbjct: 1218 MLSPKTGGKEAASGTTPQKSRKPKKGAGNPQ 1248
Score = 40.4 bits (93), Expect = 0.001
Identities = 60/277 (21%), Positives = 89/277 (32%), Gaps = 73/277 (26%)
Query: 10 KGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEK 69
K + + A K+ +GAA P P+ A+ GK+ D + + +
Sbjct: 892 KTHQIRAALAPAKESPRKGAAPT---------PPGKTGPSAAQAGKQD-DSGSSSEESDS 941
Query: 70 EGEKDAAAAKEEAPK------------AEPEKTEGAAEAKAEPPKAPEQEQAA------- 110
+GE AA + K A P T A+A + P KA E A
Sbjct: 942 DGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSES 1001
Query: 111 -------------PGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPA-- 155
PG A AP S A A+ + S + KK E PA
Sbjct: 1002 EDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQ 1061
Query: 156 -----------APAAQETKSDG-----------------AP-ASDSKPGSSEAAPSSKET 186
+P + ++ G AP +SD SS+++ S+E
Sbjct: 1062 VDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEED 1121
Query: 187 PAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTV 223
+ S GP S E E A +S+ V
Sbjct: 1122 GEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDV 1158
Score = 40.0 bits (92), Expect = 0.002
Identities = 46/215 (21%), Positives = 92/215 (42%), Gaps = 13/215 (6%)
Query: 15 NDEKAKEKDKKAEGAAT--EEEGTPKESEPQAAAEPAEAKEGKEK----PDQDAEGKAEE 68
+ E++ +++K A T + + K + +AA+ P + G+ P + +
Sbjct: 695 SSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQV 754
Query: 69 K-EGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGG--EAPKAAEA 125
K E ++D+ +++EE+ E + + + +A AA P+A G AP
Sbjct: 755 KAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVT 814
Query: 126 AAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDG-APASDSKPGSSEAAPSSK 184
AAA A+ +P+ + P + T PA+ + A A+ ++ G E + SS+
Sbjct: 815 AAAQAKQRSPSKVKPPVR--NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSE 872
Query: 185 ETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANS 219
E + E + + + P+ + + APA S
Sbjct: 873 EESDSEEEAETLAQVK-PSGKTHQIRAALAPAKES 906
Score = 33.5 bits (75), Expect = 0.15
Identities = 16/47 (34%), Positives = 27/47 (57%)
Query: 4 KLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAE 50
K KKK D++ KEK KKA+ A+T++ +P + + + + AE
Sbjct: 1402 KKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAE 1448
Score = 33.1 bits (74), Expect = 0.20
Identities = 41/186 (22%), Positives = 71/186 (38%), Gaps = 10/186 (5%)
Query: 23 DKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEA 82
+ +A A + + +P S AA + + K+ E Q A G K G K+AA+
Sbjct: 1178 NSQASKATPKLDSSPSVSSTLAAKDDPDGKQ--EAKPQQAAGMLSPKTGGKEAASGTTPQ 1235
Query: 83 PKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAE------SAAPA 136
+P+K G +A ++ + P EA A E
Sbjct: 1236 KSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVD 1295
Query: 137 AGEEPSKEEGEPKKTEAPA-APAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSS 195
+E S++ E +K + PAA+ +S + G EA+ S ++T ++ +
Sbjct: 1296 TTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEG-GEASVSPEKTSTTSKGKAK 1354
Query: 196 TPKAQG 201
KA G
Sbjct: 1355 RDKASG 1360
Score = 33.1 bits (74), Expect = 0.20
Identities = 34/146 (23%), Positives = 55/146 (37%), Gaps = 6/146 (4%)
Query: 50 EAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQA 109
E+++ K DQ A K+ +K A EA PEKT ++ KA+ KA +
Sbjct: 1306 ESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEA-SVSPEKTSTTSKGKAKRDKASGDVKE 1364
Query: 110 APGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS-----KEEGEPKKTEAPAAPAAQETKS 164
G + G E + G + S KE+ + K + ++ K+
Sbjct: 1365 KKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKA 1424
Query: 165 DGAPASDSKPGSSEAAPSSKETPAAT 190
A DS+ S + K+T T
Sbjct: 1425 KKASTKDSESPSQKKKKKKKKTAEQT 1450
Score = 31.2 bits (69), Expect = 0.76
Identities = 27/106 (25%), Positives = 47/106 (44%), Gaps = 8/106 (7%)
Query: 3 GKLSKKKKGYNVNDEKAKEKDKKAEGAATE-EEGTPKESEPQAAAEPAEAKEGKEKPDQD 61
GK + K +V ++K K ++GA E EE K + + K KEK D
Sbjct: 1351 GKAKRDKASGDVKEKKGKGS-LGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSD 1409
Query: 62 AEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQE 107
K +EK+ + K++A KA + +E ++ K + K ++
Sbjct: 1410 KRKKDKEKKEK------KKKAKKASTKDSESPSQKKKKKKKKTAEQ 1449
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 73.9 bits (180), Expect = 1e-13
Identities = 63/206 (30%), Positives = 94/206 (45%), Gaps = 12/206 (5%)
Query: 18 KAKEKDKKAEGAATEEEGTP-KESEP----QAAAEPAEAKEGKEKPDQDAEGKAEE-KEG 71
KA EK + A+ +GTP K + P +A A ++ K GK P++D+E +EE +
Sbjct: 292 KASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGK--PEEDSESSSEESSDS 349
Query: 72 EKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAE 131
E++ AAK KT A A P K ++ AAP P G P A+A A E
Sbjct: 350 EEETPAAKALLQAKASGKTSQVGAASA-PAKESPRKGAAPAP-PGKTGPAVAKAQAGKRE 407
Query: 132 SAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATE 191
+ ++ EE EE P +A + A + ++ APA +S + AP K PAA +
Sbjct: 408 EDSQSSSEESDSEEEAP--AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 465
Query: 192 APSSTPKAQGPAASAEEPKPVEAPAA 217
+ ++S E EA AA
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAA 491
Score = 72.0 bits (175), Expect = 4e-13
Identities = 62/228 (27%), Positives = 90/228 (39%), Gaps = 30/228 (13%)
Query: 19 AKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKA----EEKEGEKD 74
+ +D + T+ EG P Q A KE + A GK + +G
Sbjct: 198 SSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGAL 257
Query: 75 AAAAKEEAPKAEPEKTEGAAEAKAEPP-------KAPE---QEQAAPGPAAGGEA----- 119
A + + P+ E E +E +E++ E P KA E Q +AA PA G
Sbjct: 258 PPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATP 317
Query: 120 --PKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDG---------AP 168
P A A A+ ++ P E S EE + E PAA A + K+ G AP
Sbjct: 318 APPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAP 377
Query: 169 ASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPA 216
A +S + AP K PA +A + + ++S E EAPA
Sbjct: 378 AKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPA 425
Score = 62.4 bits (150), Expect = 3e-10
Identities = 70/242 (28%), Positives = 96/242 (39%), Gaps = 52/242 (21%)
Query: 20 KEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAK 79
K K AE +A + E E A A AK G Q A+ +E+ D
Sbjct: 155 KSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQ-ADSSSEDTSSSSDETDV- 212
Query: 80 EEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEA-PKAAEAAAAPAESAAPAAG 138
E P +P + + ++ + E P +AAP P G+ P+ A PA+ A
Sbjct: 213 EGKPSVKPAQVKASSVSTKESPA----RKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEE 268
Query: 139 EEPSKEEGEPKKTEAPA-------------------APA-------------------AQ 160
E S EEG + EAPA APA A
Sbjct: 269 ESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVAS 328
Query: 161 ETKSDGAPASDSKPGSSEAAPSSKETPAA---TEAPSSTPKAQGPAASA---EEPKPVEA 214
+TK+ G P DS+ S E++ S +ETPAA +A +S +Q AASA E P+ A
Sbjct: 329 QTKA-GKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387
Query: 215 PA 216
PA
Sbjct: 388 PA 389
Score = 60.8 bits (146), Expect = 9e-10
Identities = 59/220 (26%), Positives = 90/220 (40%), Gaps = 25/220 (11%)
Query: 9 KKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEE 68
K G V KA +K+ + ++EEE +E AAA PA+ K +K A A
Sbjct: 746 KTGPTVTQVKA---EKQEDSESSEEESDSEE----AAASPAQVKTSVKKTQAKANPAAAR 798
Query: 69 KEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQA-APGPAA----GGEAPKAA 123
K +A + A + + + P + P+ A GPA+ G AA
Sbjct: 799 APSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAA 858
Query: 124 EAAAAPAESAAPAAGEEPSKEE----------GEPKKTEAPAAPAAQETKSDGAPASDSK 173
+A P E + + E S+EE G+ + A APA + + AP K
Sbjct: 859 QAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGK 918
Query: 174 PGSSEAAPSSKETPAATEAPSSTPKAQGPAA--SAEEPKP 211
G S AA + K+ + + + S + PAA SA+ KP
Sbjct: 919 TGPS-AAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKP 957
Score = 54.3 bits (129), Expect = 8e-08
Identities = 61/208 (29%), Positives = 91/208 (43%), Gaps = 34/208 (16%)
Query: 2 GGKLSKKKKGYNVNDEKAK-------EKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEG 54
G S+ K G D ++ E++ A A + + + K S+ AA+ PA
Sbjct: 324 GAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPA----- 378
Query: 55 KEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPA 114
KE P +G A G+ A AK +A K E + + E+ +E E+A
Sbjct: 379 KESP---RKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE-------EEAPAQAK 428
Query: 115 AGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKP 174
G+AP+ AA+APA+ +P G P+ P+KT PAA Q K + DS+
Sbjct: 429 PSGKAPQ-VRAASAPAKE-SPRKGAAPA----PPRKT-GPAAAQVQVGKQE----EDSR- 476
Query: 175 GSSEAAPSSKETPAATEAPSSTPKAQGP 202
SSE + S +E AA A P + P
Sbjct: 477 SSSEESDSDREALAAMNAAQVKPLGKSP 504
Score = 50.1 bits (118), Expect = 2e-06
Identities = 59/238 (24%), Positives = 90/238 (37%), Gaps = 44/238 (18%)
Query: 18 KAKEKDKKAEGAATEEEGTPKESE---PQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKD 74
KA K + A+ + +P++ P PA AK K ++D++ +EE + E++
Sbjct: 363 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEE 422
Query: 75 AAAAKEEAPKAEPEKTEGAAEAKAEPPK-APEQEQAAPGPAAGG---------------E 118
A A + + KA P+ +A AK P K A GPAA E
Sbjct: 423 APAQAKPSGKA-PQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEE 481
Query: 119 APKAAEAAAAPAESAAPAAGEEPSKEEGE--------------PKKTEAPAAPAAQETKS 164
+ EA AA + G+ P + P PA P+AQ K
Sbjct: 482 SDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKW 541
Query: 165 DGAPASDSKPGSSEAAPSSK-ETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQ 221
+ DS+ S E++ SS E P A P + + + KP +PA Q
Sbjct: 542 E----EDSESSSEESSDSSDGEVPTAV-----APAQEKSLGNILQAKPTSSPAKGPPQ 590
Score = 48.1 bits (113), Expect = 6e-06
Identities = 52/210 (24%), Positives = 83/210 (39%), Gaps = 23/210 (10%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEG--EKDAAAAKEEA----------P 83
+P + PQ A P + EKP ++E E + ++A AA A
Sbjct: 583 SPAKGPPQKAG-PVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQT 641
Query: 84 KAEPEKTEGAAEAKAEP----PKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGE 139
KA P+KT A AK P +AP + A PA G +P A PAE ++ +
Sbjct: 642 KACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA--GSSPAVAGGTQRPAEDSSSSEES 699
Query: 140 EPSKEEGEPKKT--EAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTP 197
+ +E+ T +A + + K+ P S + K P T+ +
Sbjct: 700 DSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAE-- 757
Query: 198 KAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
K + +S EE EA A+ + +VK+
Sbjct: 758 KQEDSESSEEESDSEEAAASPAQVKTSVKK 787
Score = 47.4 bits (111), Expect = 1e-05
Identities = 57/252 (22%), Positives = 96/252 (38%), Gaps = 50/252 (19%)
Query: 2 GGKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEK---- 57
G ++K + G D ++ ++ +E A + P PQ A A AKE K
Sbjct: 395 GPAVAKAQAGKREEDSQSSSEESDSEEEAPAQ-AKPSGKAPQVRAASAPAKESPRKGAAP 453
Query: 58 -----------------PDQDAEGKAEEKEGEKDAAAAKEEA--------PKAEPEKTEG 92
++D+ +EE + +++A AA A P+ +P T G
Sbjct: 454 APPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMG 513
Query: 93 AAE-AKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS-------KE 144
K P P + A A G+ + +E+++ ES+ + GE P+ K
Sbjct: 514 MGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE--ESSDSSDGEVPTAVAPAQEKS 571
Query: 145 EG---EPKKTEAPA-------APAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPS 194
G + K T +PA P A + K++ + S + S+E PAA A
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQ 631
Query: 195 STPKAQGPAASA 206
+ P + P A
Sbjct: 632 AKPALKIPQTKA 643
Score = 47.4 bits (111), Expect = 1e-05
Identities = 49/187 (26%), Positives = 85/187 (45%), Gaps = 18/187 (9%)
Query: 44 AAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKA 103
A + PA A G ++P +D+ +EE + E++ +A+ +A + P K
Sbjct: 676 AGSSPAVAG-GTQRPAEDSSS-SEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG 733
Query: 104 PEQEQAAP------GPAAGG-EAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAA 156
+ AP GP +A K ++ ++ ES + A P++ + KKT+A A
Sbjct: 734 SLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKAN 793
Query: 157 PAAQETKSDGAPASDSKPGS--SEAAPSSKETPAATEAP-----SSTPKAQGPAASAEEP 209
PAA ++ A + S PG + AA + + +P+ + P +ST A+GPA+
Sbjct: 794 PAA--ARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVG 851
Query: 210 KPVEAPA 216
K V A
Sbjct: 852 KAVATAA 858
Score = 45.1 bits (105), Expect = 5e-05
Identities = 44/211 (20%), Positives = 78/211 (36%), Gaps = 5/211 (2%)
Query: 14 VNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEG-KEKPDQDAEGKAEEKEGE 72
++ ++ E++++AE A + TP+ + ++ A+ KEK + E +
Sbjct: 82 ISTSESSEEEEEAE--AETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSM 139
Query: 73 KDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEA-PKAAEAAAAPAE 131
A K A + +AE A E E+ PA G A P A A +
Sbjct: 140 PHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSS 199
Query: 132 SAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGS-SEAAPSSKETPAAT 190
S ++ + + EG+P A ++ TK A + PG + P K
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPP 259
Query: 191 EAPSSTPKAQGPAASAEEPKPVEAPAANSDQ 221
+ P+ + ++ EAPA Q
Sbjct: 260 AKRAKKPEEESESSEEGSESEEEAPAGTRSQ 290
Score = 45.1 bits (105), Expect = 5e-05
Identities = 33/167 (19%), Positives = 60/167 (35%), Gaps = 8/167 (4%)
Query: 58 PDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEK--------TEGAAEAKAEPPKAPEQEQA 109
P G + KE + + K+E P + K T+ A + A+ + A
Sbjct: 1033 PKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVA 1092
Query: 110 APGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPA 169
P++G ++ A +P ++ A G ++ P+ +A AP + + D + +
Sbjct: 1093 RTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDS 1152
Query: 170 SDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPA 216
S E +K PS T A+ V AP+
Sbjct: 1153 SSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPS 1199
Score = 45.1 bits (105), Expect = 5e-05
Identities = 43/169 (25%), Positives = 68/169 (40%), Gaps = 12/169 (7%)
Query: 27 EGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKE---GEKDAAAAKEEAP 83
+ T + PK E Q A + E+ + E + G E+ E G K A
Sbjct: 1118 QAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPS 1177
Query: 84 KAEPEKTEGAAEAKAEPPKAPEQE----QAAPG-PAAGGEAPKAA-EAAAAPAESAAPAA 137
+ E E AAE+ + AP Q PG A +A KA + ++P+ S+ AA
Sbjct: 1178 RTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAA 1237
Query: 138 GEEP-SKEEGEPKKTEAPAAP--AAQETKSDGAPASDSKPGSSEAAPSS 183
++P K+E +P++ +P +E S P KP P +
Sbjct: 1238 KDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQA 1286
Score = 44.3 bits (103), Expect = 9e-05
Identities = 57/224 (25%), Positives = 90/224 (40%), Gaps = 52/224 (23%)
Query: 22 KDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEE 81
+ +KAE A + + S+P + +E +E +E E KA + +++ +
Sbjct: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAET----AKATPRLASTNSSVLGAD 116
Query: 82 APKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEP 141
P + EK AKAE KA + + P PA G + A +P EP
Sbjct: 117 LPSSMKEK------AKAETEKAGKTGNSMPHPATG-------KTVANLLSGKSPRKSAEP 163
Query: 142 S---------KEEGEPKKTEAPAAPA------AQETKSDGAPASDS---------KPGSS 177
S +EEG A A P A + D + +SD KP
Sbjct: 164 SANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQV 223
Query: 178 EAAP-SSKETPAATEAPSS------TPKAQG----PAASAEEPK 210
+A+ S+KE+PA AP+ TP+ +G PA A++P+
Sbjct: 224 KASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPE 267
Score = 40.0 bits (92), Expect = 0.002
Identities = 46/215 (21%), Positives = 92/215 (42%), Gaps = 13/215 (6%)
Query: 15 NDEKAKEKDKKAEGAAT--EEEGTPKESEPQAAAEPAEAKEGKEK----PDQDAEGKAEE 68
+ E++ +++K A T + + K + +AA+ P + G+ P + +
Sbjct: 695 SSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQV 754
Query: 69 K-EGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGG--EAPKAAEA 125
K E ++D+ +++EE+ E + + + +A AA P+A G AP
Sbjct: 755 KAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVT 814
Query: 126 AAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDG-APASDSKPGSSEAAPSSK 184
AAA A+ +P+ + P + T PA+ + A A+ ++ G E + SS+
Sbjct: 815 AAAQAKQRSPSKVKPPVR--NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSE 872
Query: 185 ETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANS 219
E + E + + + P+ + + APA S
Sbjct: 873 EESDSEEEAETLAQVK-PSGKTHQIRAALAPAKES 906
Score = 33.5 bits (75), Expect = 0.15
Identities = 16/47 (34%), Positives = 27/47 (57%)
Query: 4 KLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAE 50
K KKK D++ KEK KKA+ A+T++ +P + + + + AE
Sbjct: 1439 KKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAE 1485
Score = 33.1 bits (74), Expect = 0.20
Identities = 34/146 (23%), Positives = 55/146 (37%), Gaps = 6/146 (4%)
Query: 50 EAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQA 109
E+++ K DQ A K+ +K A EA PEKT ++ KA+ KA +
Sbjct: 1343 ESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEA-SVSPEKTSTTSKGKAKRDKASGDVKE 1401
Query: 110 APGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS-----KEEGEPKKTEAPAAPAAQETKS 164
G + G E + G + S KE+ + K + ++ K+
Sbjct: 1402 KKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKA 1461
Query: 165 DGAPASDSKPGSSEAAPSSKETPAAT 190
A DS+ S + K+T T
Sbjct: 1462 KKASTKDSESPSQKKKKKKKKTAEQT 1487
Score = 31.2 bits (69), Expect = 0.76
Identities = 27/106 (25%), Positives = 47/106 (44%), Gaps = 8/106 (7%)
Query: 3 GKLSKKKKGYNVNDEKAKEKDKKAEGAATE-EEGTPKESEPQAAAEPAEAKEGKEKPDQD 61
GK + K +V ++K K ++GA E EE K + + K KEK D
Sbjct: 1388 GKAKRDKASGDVKEKKGKGS-LGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSD 1446
Query: 62 AEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQE 107
K +EK+ + K++A KA + +E ++ K + K ++
Sbjct: 1447 KRKKDKEKKEK------KKKAKKASTKDSESPSQKKKKKKKKTAEQ 1486
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
[Homo sapiens]
Length = 1411
Score = 73.9 bits (180), Expect = 1e-13
Identities = 63/206 (30%), Positives = 94/206 (45%), Gaps = 12/206 (5%)
Query: 18 KAKEKDKKAEGAATEEEGTP-KESEP----QAAAEPAEAKEGKEKPDQDAEGKAEE-KEG 71
KA EK + A+ +GTP K + P +A A ++ K GK P++D+E +EE +
Sbjct: 215 KASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGK--PEEDSESSSEESSDS 272
Query: 72 EKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAE 131
E++ AAK KT A A P K ++ AAP P G P A+A A E
Sbjct: 273 EEETPAAKALLQAKASGKTSQVGAASA-PAKESPRKGAAPAP-PGKTGPAVAKAQAGKRE 330
Query: 132 SAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATE 191
+ ++ EE EE P +A + A + ++ APA +S + AP K PAA +
Sbjct: 331 EDSQSSSEESDSEEEAP--AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 388
Query: 192 APSSTPKAQGPAASAEEPKPVEAPAA 217
+ ++S E EA AA
Sbjct: 389 VQVGKQEEDSRSSSEESDSDREALAA 414
Score = 63.9 bits (154), Expect = 1e-10
Identities = 57/206 (27%), Positives = 80/206 (38%), Gaps = 21/206 (10%)
Query: 20 KEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAK 79
K K AE +A + E E A A AK G Q A+ +E+ D +
Sbjct: 155 KSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQ-ADSSSEDTSSSSDETDVE 213
Query: 80 EEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGE 139
+A + + +A AK P K A P P P A A A+ ++ P
Sbjct: 214 VKASEKILQVRAASAPAKGTPGKG-----ATPAP------PGKAGAVASQTKAGKPEEDS 262
Query: 140 EPSKEEGEPKKTEAPAAPAAQETKSDG---------APASDSKPGSSEAAPSSKETPAAT 190
E S EE + E PAA A + K+ G APA +S + AP K PA
Sbjct: 263 ESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVA 322
Query: 191 EAPSSTPKAQGPAASAEEPKPVEAPA 216
+A + + ++S E EAPA
Sbjct: 323 KAQAGKREEDSQSSSEESDSEEEAPA 348
Score = 60.8 bits (146), Expect = 9e-10
Identities = 59/220 (26%), Positives = 90/220 (40%), Gaps = 25/220 (11%)
Query: 9 KKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEE 68
K G V KA +K+ + ++EEE +E AAA PA+ K +K A A
Sbjct: 669 KTGPTVTQVKA---EKQEDSESSEEESDSEE----AAASPAQVKTSVKKTQAKANPAAAR 721
Query: 69 KEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQA-APGPAA----GGEAPKAA 123
K +A + A + + + P + P+ A GPA+ G AA
Sbjct: 722 APSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAA 781
Query: 124 EAAAAPAESAAPAAGEEPSKEE----------GEPKKTEAPAAPAAQETKSDGAPASDSK 173
+A P E + + E S+EE G+ + A APA + + AP K
Sbjct: 782 QAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGK 841
Query: 174 PGSSEAAPSSKETPAATEAPSSTPKAQGPAA--SAEEPKP 211
G S AA + K+ + + + S + PAA SA+ KP
Sbjct: 842 TGPS-AAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKP 880
Score = 54.3 bits (129), Expect = 8e-08
Identities = 61/208 (29%), Positives = 91/208 (43%), Gaps = 34/208 (16%)
Query: 2 GGKLSKKKKGYNVNDEKAK-------EKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEG 54
G S+ K G D ++ E++ A A + + + K S+ AA+ PA
Sbjct: 247 GAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPA----- 301
Query: 55 KEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPA 114
KE P +G A G+ A AK +A K E + + E+ +E E+A
Sbjct: 302 KESP---RKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE-------EEAPAQAK 351
Query: 115 AGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKP 174
G+AP+ AA+APA+ +P G P+ P+KT PAA Q K + DS+
Sbjct: 352 PSGKAPQ-VRAASAPAKE-SPRKGAAPA----PPRKT-GPAAAQVQVGKQE----EDSR- 399
Query: 175 GSSEAAPSSKETPAATEAPSSTPKAQGP 202
SSE + S +E AA A P + P
Sbjct: 400 SSSEESDSDREALAAMNAAQVKPLGKSP 427
Score = 50.1 bits (118), Expect = 2e-06
Identities = 59/238 (24%), Positives = 90/238 (37%), Gaps = 44/238 (18%)
Query: 18 KAKEKDKKAEGAATEEEGTPKESE---PQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKD 74
KA K + A+ + +P++ P PA AK K ++D++ +EE + E++
Sbjct: 286 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEE 345
Query: 75 AAAAKEEAPKAEPEKTEGAAEAKAEPPK-APEQEQAAPGPAAGG---------------E 118
A A + + KA P+ +A AK P K A GPAA E
Sbjct: 346 APAQAKPSGKA-PQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEE 404
Query: 119 APKAAEAAAAPAESAAPAAGEEPSKEEGE--------------PKKTEAPAAPAAQETKS 164
+ EA AA + G+ P + P PA P+AQ K
Sbjct: 405 SDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKW 464
Query: 165 DGAPASDSKPGSSEAAPSSK-ETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQ 221
+ DS+ S E++ SS E P A P + + + KP +PA Q
Sbjct: 465 E----EDSESSSEESSDSSDGEVPTAV-----APAQEKSLGNILQAKPTSSPAKGPPQ 513
Score = 48.9 bits (115), Expect = 4e-06
Identities = 52/225 (23%), Positives = 89/225 (39%), Gaps = 30/225 (13%)
Query: 22 KDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEE 81
+ +KAE A + + S+P + +E +E +E E KA + +++ +
Sbjct: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAET----AKATPRLASTNSSVLGAD 116
Query: 82 APKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGE-- 139
P + EK AKAE KA + + P PA G + +P +SA P+A
Sbjct: 117 LPSSMKEK------AKAETEKAGKTGNSMPHPATGKTVANLL-SGKSPRKSAEPSANTTL 169
Query: 140 -EPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSE----------------AAPS 182
++EEG A A P + + D+ S E A+
Sbjct: 170 VSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAP 229
Query: 183 SKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
+K TP P+ KA A+ + KP E ++S+++ +E
Sbjct: 230 AKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEE 274
Score = 48.1 bits (113), Expect = 6e-06
Identities = 52/210 (24%), Positives = 83/210 (39%), Gaps = 23/210 (10%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEG--EKDAAAAKEEA----------P 83
+P + PQ A P + EKP ++E E + ++A AA A
Sbjct: 506 SPAKGPPQKAG-PVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQT 564
Query: 84 KAEPEKTEGAAEAKAEP----PKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGE 139
KA P+KT A AK P +AP + A PA G +P A PAE ++ +
Sbjct: 565 KACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA--GSSPAVAGGTQRPAEDSSSSEES 622
Query: 140 EPSKEEGEPKKT--EAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTP 197
+ +E+ T +A + + K+ P S + K P T+ +
Sbjct: 623 DSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAE-- 680
Query: 198 KAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
K + +S EE EA A+ + +VK+
Sbjct: 681 KQEDSESSEEESDSEEAAASPAQVKTSVKK 710
Score = 47.4 bits (111), Expect = 1e-05
Identities = 57/252 (22%), Positives = 96/252 (38%), Gaps = 50/252 (19%)
Query: 2 GGKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEK---- 57
G ++K + G D ++ ++ +E A + P PQ A A AKE K
Sbjct: 318 GPAVAKAQAGKREEDSQSSSEESDSEEEAPAQ-AKPSGKAPQVRAASAPAKESPRKGAAP 376
Query: 58 -----------------PDQDAEGKAEEKEGEKDAAAAKEEA--------PKAEPEKTEG 92
++D+ +EE + +++A AA A P+ +P T G
Sbjct: 377 APPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMG 436
Query: 93 AAE-AKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS-------KE 144
K P P + A A G+ + +E+++ ES+ + GE P+ K
Sbjct: 437 MGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE--ESSDSSDGEVPTAVAPAQEKS 494
Query: 145 EG---EPKKTEAPA-------APAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPS 194
G + K T +PA P A + K++ + S + S+E PAA A
Sbjct: 495 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQ 554
Query: 195 STPKAQGPAASA 206
+ P + P A
Sbjct: 555 AKPALKIPQTKA 566
Score = 47.4 bits (111), Expect = 1e-05
Identities = 49/187 (26%), Positives = 85/187 (45%), Gaps = 18/187 (9%)
Query: 44 AAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKA 103
A + PA A G ++P +D+ +EE + E++ +A+ +A + P K
Sbjct: 599 AGSSPAVAG-GTQRPAEDSSS-SEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG 656
Query: 104 PEQEQAAP------GPAAGG-EAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAA 156
+ AP GP +A K ++ ++ ES + A P++ + KKT+A A
Sbjct: 657 SLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKAN 716
Query: 157 PAAQETKSDGAPASDSKPGS--SEAAPSSKETPAATEAP-----SSTPKAQGPAASAEEP 209
PAA ++ A + S PG + AA + + +P+ + P +ST A+GPA+
Sbjct: 717 PAA--ARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVG 774
Query: 210 KPVEAPA 216
K V A
Sbjct: 775 KAVATAA 781
Score = 45.1 bits (105), Expect = 5e-05
Identities = 33/167 (19%), Positives = 60/167 (35%), Gaps = 8/167 (4%)
Query: 58 PDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEK--------TEGAAEAKAEPPKAPEQEQA 109
P G + KE + + K+E P + K T+ A + A+ + A
Sbjct: 956 PKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVA 1015
Query: 110 APGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPA 169
P++G ++ A +P ++ A G ++ P+ +A AP + + D + +
Sbjct: 1016 RTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDS 1075
Query: 170 SDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPA 216
S E +K PS T A+ V AP+
Sbjct: 1076 SSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPS 1122
Score = 45.1 bits (105), Expect = 5e-05
Identities = 43/169 (25%), Positives = 68/169 (40%), Gaps = 12/169 (7%)
Query: 27 EGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKE---GEKDAAAAKEEAP 83
+ T + PK E Q A + E+ + E + G E+ E G K A
Sbjct: 1041 QAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPS 1100
Query: 84 KAEPEKTEGAAEAKAEPPKAPEQE----QAAPG-PAAGGEAPKAA-EAAAAPAESAAPAA 137
+ E E AAE+ + AP Q PG A +A KA + ++P+ S+ AA
Sbjct: 1101 RTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAA 1160
Query: 138 GEEP-SKEEGEPKKTEAPAAP--AAQETKSDGAPASDSKPGSSEAAPSS 183
++P K+E +P++ +P +E S P KP P +
Sbjct: 1161 KDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQA 1209
Score = 40.0 bits (92), Expect = 0.002
Identities = 46/215 (21%), Positives = 92/215 (42%), Gaps = 13/215 (6%)
Query: 15 NDEKAKEKDKKAEGAAT--EEEGTPKESEPQAAAEPAEAKEGKEK----PDQDAEGKAEE 68
+ E++ +++K A T + + K + +AA+ P + G+ P + +
Sbjct: 618 SSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQV 677
Query: 69 K-EGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGG--EAPKAAEA 125
K E ++D+ +++EE+ E + + + +A AA P+A G AP
Sbjct: 678 KAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVT 737
Query: 126 AAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDG-APASDSKPGSSEAAPSSK 184
AAA A+ +P+ + P + T PA+ + A A+ ++ G E + SS+
Sbjct: 738 AAAQAKQRSPSKVKPPVR--NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSE 795
Query: 185 ETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANS 219
E + E + + + P+ + + APA S
Sbjct: 796 EESDSEEEAETLAQVK-PSGKTHQIRAALAPAKES 829
Score = 33.5 bits (75), Expect = 0.15
Identities = 16/47 (34%), Positives = 27/47 (57%)
Query: 4 KLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAE 50
K KKK D++ KEK KKA+ A+T++ +P + + + + AE
Sbjct: 1362 KKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAE 1408
Score = 33.1 bits (74), Expect = 0.20
Identities = 34/146 (23%), Positives = 55/146 (37%), Gaps = 6/146 (4%)
Query: 50 EAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQA 109
E+++ K DQ A K+ +K A EA PEKT ++ KA+ KA +
Sbjct: 1266 ESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEA-SVSPEKTSTTSKGKAKRDKASGDVKE 1324
Query: 110 APGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS-----KEEGEPKKTEAPAAPAAQETKS 164
G + G E + G + S KE+ + K + ++ K+
Sbjct: 1325 KKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKA 1384
Query: 165 DGAPASDSKPGSSEAAPSSKETPAAT 190
A DS+ S + K+T T
Sbjct: 1385 KKASTKDSESPSQKKKKKKKKTAEQT 1410
Score = 31.2 bits (69), Expect = 0.76
Identities = 27/106 (25%), Positives = 47/106 (44%), Gaps = 8/106 (7%)
Query: 3 GKLSKKKKGYNVNDEKAKEKDKKAEGAATE-EEGTPKESEPQAAAEPAEAKEGKEKPDQD 61
GK + K +V ++K K ++GA E EE K + + K KEK D
Sbjct: 1311 GKAKRDKASGDVKEKKGKGS-LGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSD 1369
Query: 62 AEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQE 107
K +EK+ + K++A KA + +E ++ K + K ++
Sbjct: 1370 KRKKDKEKKEK------KKKAKKASTKDSESPSQKKKKKKKKTAEQ 1409
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 73.9 bits (180), Expect = 1e-13
Identities = 63/206 (30%), Positives = 94/206 (45%), Gaps = 12/206 (5%)
Query: 18 KAKEKDKKAEGAATEEEGTP-KESEP----QAAAEPAEAKEGKEKPDQDAEGKAEE-KEG 71
KA EK + A+ +GTP K + P +A A ++ K GK P++D+E +EE +
Sbjct: 292 KASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGK--PEEDSESSSEESSDS 349
Query: 72 EKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAE 131
E++ AAK KT A A P K ++ AAP P G P A+A A E
Sbjct: 350 EEETPAAKALLQAKASGKTSQVGAASA-PAKESPRKGAAPAP-PGKTGPAVAKAQAGKRE 407
Query: 132 SAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATE 191
+ ++ EE EE P +A + A + ++ APA +S + AP K PAA +
Sbjct: 408 EDSQSSSEESDSEEEAP--AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 465
Query: 192 APSSTPKAQGPAASAEEPKPVEAPAA 217
+ ++S E EA AA
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAA 491
Score = 72.0 bits (175), Expect = 4e-13
Identities = 62/228 (27%), Positives = 90/228 (39%), Gaps = 30/228 (13%)
Query: 19 AKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKA----EEKEGEKD 74
+ +D + T+ EG P Q A KE + A GK + +G
Sbjct: 198 SSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGAL 257
Query: 75 AAAAKEEAPKAEPEKTEGAAEAKAEPP-------KAPE---QEQAAPGPAAGGEA----- 119
A + + P+ E E +E +E++ E P KA E Q +AA PA G
Sbjct: 258 PPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATP 317
Query: 120 --PKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDG---------AP 168
P A A A+ ++ P E S EE + E PAA A + K+ G AP
Sbjct: 318 APPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAP 377
Query: 169 ASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPA 216
A +S + AP K PA +A + + ++S E EAPA
Sbjct: 378 AKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPA 425
Score = 62.4 bits (150), Expect = 3e-10
Identities = 70/242 (28%), Positives = 96/242 (39%), Gaps = 52/242 (21%)
Query: 20 KEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAK 79
K K AE +A + E E A A AK G Q A+ +E+ D
Sbjct: 155 KSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQ-ADSSSEDTSSSSDETDV- 212
Query: 80 EEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEA-PKAAEAAAAPAESAAPAAG 138
E P +P + + ++ + E P +AAP P G+ P+ A PA+ A
Sbjct: 213 EGKPSVKPAQVKASSVSTKESPA----RKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEE 268
Query: 139 EEPSKEEGEPKKTEAPA-------------------APA-------------------AQ 160
E S EEG + EAPA APA A
Sbjct: 269 ESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVAS 328
Query: 161 ETKSDGAPASDSKPGSSEAAPSSKETPAA---TEAPSSTPKAQGPAASA---EEPKPVEA 214
+TK+ G P DS+ S E++ S +ETPAA +A +S +Q AASA E P+ A
Sbjct: 329 QTKA-GKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387
Query: 215 PA 216
PA
Sbjct: 388 PA 389
Score = 60.8 bits (146), Expect = 9e-10
Identities = 59/220 (26%), Positives = 90/220 (40%), Gaps = 25/220 (11%)
Query: 9 KKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEE 68
K G V KA +K+ + ++EEE +E AAA PA+ K +K A A
Sbjct: 746 KTGPTVTQVKA---EKQEDSESSEEESDSEE----AAASPAQVKTSVKKTQAKANPAAAR 798
Query: 69 KEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQA-APGPAA----GGEAPKAA 123
K +A + A + + + P + P+ A GPA+ G AA
Sbjct: 799 APSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAA 858
Query: 124 EAAAAPAESAAPAAGEEPSKEE----------GEPKKTEAPAAPAAQETKSDGAPASDSK 173
+A P E + + E S+EE G+ + A APA + + AP K
Sbjct: 859 QAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGK 918
Query: 174 PGSSEAAPSSKETPAATEAPSSTPKAQGPAA--SAEEPKP 211
G S AA + K+ + + + S + PAA SA+ KP
Sbjct: 919 TGPS-AAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKP 957
Score = 54.3 bits (129), Expect = 8e-08
Identities = 61/208 (29%), Positives = 91/208 (43%), Gaps = 34/208 (16%)
Query: 2 GGKLSKKKKGYNVNDEKAK-------EKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEG 54
G S+ K G D ++ E++ A A + + + K S+ AA+ PA
Sbjct: 324 GAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPA----- 378
Query: 55 KEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPA 114
KE P +G A G+ A AK +A K E + + E+ +E E+A
Sbjct: 379 KESP---RKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE-------EEAPAQAK 428
Query: 115 AGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKP 174
G+AP+ AA+APA+ +P G P+ P+KT PAA Q K + DS+
Sbjct: 429 PSGKAPQ-VRAASAPAKE-SPRKGAAPA----PPRKT-GPAAAQVQVGKQE----EDSR- 476
Query: 175 GSSEAAPSSKETPAATEAPSSTPKAQGP 202
SSE + S +E AA A P + P
Sbjct: 477 SSSEESDSDREALAAMNAAQVKPLGKSP 504
Score = 50.1 bits (118), Expect = 2e-06
Identities = 59/238 (24%), Positives = 90/238 (37%), Gaps = 44/238 (18%)
Query: 18 KAKEKDKKAEGAATEEEGTPKESE---PQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKD 74
KA K + A+ + +P++ P PA AK K ++D++ +EE + E++
Sbjct: 363 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEE 422
Query: 75 AAAAKEEAPKAEPEKTEGAAEAKAEPPK-APEQEQAAPGPAAGG---------------E 118
A A + + KA P+ +A AK P K A GPAA E
Sbjct: 423 APAQAKPSGKA-PQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEE 481
Query: 119 APKAAEAAAAPAESAAPAAGEEPSKEEGE--------------PKKTEAPAAPAAQETKS 164
+ EA AA + G+ P + P PA P+AQ K
Sbjct: 482 SDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKW 541
Query: 165 DGAPASDSKPGSSEAAPSSK-ETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQ 221
+ DS+ S E++ SS E P A P + + + KP +PA Q
Sbjct: 542 E----EDSESSSEESSDSSDGEVPTAV-----APAQEKSLGNILQAKPTSSPAKGPPQ 590
Score = 48.1 bits (113), Expect = 6e-06
Identities = 52/210 (24%), Positives = 83/210 (39%), Gaps = 23/210 (10%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEG--EKDAAAAKEEA----------P 83
+P + PQ A P + EKP ++E E + ++A AA A
Sbjct: 583 SPAKGPPQKAG-PVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQT 641
Query: 84 KAEPEKTEGAAEAKAEP----PKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGE 139
KA P+KT A AK P +AP + A PA G +P A PAE ++ +
Sbjct: 642 KACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA--GSSPAVAGGTQRPAEDSSSSEES 699
Query: 140 EPSKEEGEPKKT--EAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTP 197
+ +E+ T +A + + K+ P S + K P T+ +
Sbjct: 700 DSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAE-- 757
Query: 198 KAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
K + +S EE EA A+ + +VK+
Sbjct: 758 KQEDSESSEEESDSEEAAASPAQVKTSVKK 787
Score = 47.4 bits (111), Expect = 1e-05
Identities = 57/252 (22%), Positives = 96/252 (38%), Gaps = 50/252 (19%)
Query: 2 GGKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEK---- 57
G ++K + G D ++ ++ +E A + P PQ A A AKE K
Sbjct: 395 GPAVAKAQAGKREEDSQSSSEESDSEEEAPAQ-AKPSGKAPQVRAASAPAKESPRKGAAP 453
Query: 58 -----------------PDQDAEGKAEEKEGEKDAAAAKEEA--------PKAEPEKTEG 92
++D+ +EE + +++A AA A P+ +P T G
Sbjct: 454 APPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMG 513
Query: 93 AAE-AKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS-------KE 144
K P P + A A G+ + +E+++ ES+ + GE P+ K
Sbjct: 514 MGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE--ESSDSSDGEVPTAVAPAQEKS 571
Query: 145 EG---EPKKTEAPA-------APAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPS 194
G + K T +PA P A + K++ + S + S+E PAA A
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQ 631
Query: 195 STPKAQGPAASA 206
+ P + P A
Sbjct: 632 AKPALKIPQTKA 643
Score = 47.4 bits (111), Expect = 1e-05
Identities = 49/187 (26%), Positives = 85/187 (45%), Gaps = 18/187 (9%)
Query: 44 AAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKA 103
A + PA A G ++P +D+ +EE + E++ +A+ +A + P K
Sbjct: 676 AGSSPAVAG-GTQRPAEDSSS-SEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG 733
Query: 104 PEQEQAAP------GPAAGG-EAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAA 156
+ AP GP +A K ++ ++ ES + A P++ + KKT+A A
Sbjct: 734 SLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKAN 793
Query: 157 PAAQETKSDGAPASDSKPGS--SEAAPSSKETPAATEAP-----SSTPKAQGPAASAEEP 209
PAA ++ A + S PG + AA + + +P+ + P +ST A+GPA+
Sbjct: 794 PAA--ARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVG 851
Query: 210 KPVEAPA 216
K V A
Sbjct: 852 KAVATAA 858
Score = 45.4 bits (106), Expect = 4e-05
Identities = 52/210 (24%), Positives = 85/210 (40%), Gaps = 37/210 (17%)
Query: 11 GYNVNDEKAKEKD-KKAEGAATEEE---GTPKESEPQA---------------------A 45
G + + E ++ D KK EG AT+ + GT + PQ+ A
Sbjct: 1039 GASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQA 1098
Query: 46 AEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKT---EGAAEAKAEPPK 102
+ E+ + E + G E+ EG + A +A P +T E AAE+ +
Sbjct: 1099 TKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVV 1158
Query: 103 APEQE----QAAPG-PAAGGEAPKAA-EAAAAPAESAAPAAGEEP-SKEEGEPKKTEAPA 155
AP Q PG A +A KA + ++P+ S+ AA ++P K+E +P++
Sbjct: 1159 APSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGML 1218
Query: 156 AP--AAQETKSDGAPASDSKPGSSEAAPSS 183
+P +E S P KP P +
Sbjct: 1219 SPKTGGKEAASGTTPQKSRKPKKGAGNPQA 1248
Score = 45.1 bits (105), Expect = 5e-05
Identities = 44/211 (20%), Positives = 78/211 (36%), Gaps = 5/211 (2%)
Query: 14 VNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEG-KEKPDQDAEGKAEEKEGE 72
++ ++ E++++AE A + TP+ + ++ A+ KEK + E +
Sbjct: 82 ISTSESSEEEEEAE--AETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSM 139
Query: 73 KDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEA-PKAAEAAAAPAE 131
A K A + +AE A E E+ PA G A P A A +
Sbjct: 140 PHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSS 199
Query: 132 SAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGS-SEAAPSSKETPAAT 190
S ++ + + EG+P A ++ TK A + PG + P K
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPP 259
Query: 191 EAPSSTPKAQGPAASAEEPKPVEAPAANSDQ 221
+ P+ + ++ EAPA Q
Sbjct: 260 AKRAKKPEEESESSEEGSESEEEAPAGTRSQ 290
Score = 44.3 bits (103), Expect = 9e-05
Identities = 57/224 (25%), Positives = 90/224 (40%), Gaps = 52/224 (23%)
Query: 22 KDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEE 81
+ +KAE A + + S+P + +E +E +E E KA + +++ +
Sbjct: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAET----AKATPRLASTNSSVLGAD 116
Query: 82 APKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEP 141
P + EK AKAE KA + + P PA G + A +P EP
Sbjct: 117 LPSSMKEK------AKAETEKAGKTGNSMPHPATG-------KTVANLLSGKSPRKSAEP 163
Query: 142 S---------KEEGEPKKTEAPAAPA------AQETKSDGAPASDS---------KPGSS 177
S +EEG A A P A + D + +SD KP
Sbjct: 164 SANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQV 223
Query: 178 EAAP-SSKETPAATEAPSS------TPKAQG----PAASAEEPK 210
+A+ S+KE+PA AP+ TP+ +G PA A++P+
Sbjct: 224 KASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPE 267
Score = 40.0 bits (92), Expect = 0.002
Identities = 46/215 (21%), Positives = 92/215 (42%), Gaps = 13/215 (6%)
Query: 15 NDEKAKEKDKKAEGAAT--EEEGTPKESEPQAAAEPAEAKEGKEK----PDQDAEGKAEE 68
+ E++ +++K A T + + K + +AA+ P + G+ P + +
Sbjct: 695 SSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQV 754
Query: 69 K-EGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGG--EAPKAAEA 125
K E ++D+ +++EE+ E + + + +A AA P+A G AP
Sbjct: 755 KAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVT 814
Query: 126 AAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDG-APASDSKPGSSEAAPSSK 184
AAA A+ +P+ + P + T PA+ + A A+ ++ G E + SS+
Sbjct: 815 AAAQAKQRSPSKVKPPVR--NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSE 872
Query: 185 ETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANS 219
E + E + + + P+ + + APA S
Sbjct: 873 EESDSEEEAETLAQVK-PSGKTHQIRAALAPAKES 906
Score = 38.1 bits (87), Expect = 0.006
Identities = 39/198 (19%), Positives = 67/198 (33%), Gaps = 18/198 (9%)
Query: 37 PKESEPQAAAEPAEAKEG----KEKPDQDAEGKAEEKEGEKDAAAAKE-----------E 81
P S AA PA+A+ K + + + + ++D A +
Sbjct: 964 PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 1023
Query: 82 APKAEPEKTEGAAEAKAEPPKAPEQ---EQAAPGPAAGGEAPKAAEAAAAPAESAAPAAG 138
P A P A+ A A K + + GPA ++ A +P ++ A G
Sbjct: 1024 MPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKG 1083
Query: 139 EEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPK 198
++ P+ +A AP + + D + +S E +K PS T
Sbjct: 1084 TNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTET 1143
Query: 199 AQGPAASAEEPKPVEAPA 216
A+ V AP+
Sbjct: 1144 LVEETAAESSEDDVVAPS 1161
Score = 33.5 bits (75), Expect = 0.15
Identities = 16/47 (34%), Positives = 27/47 (57%)
Query: 4 KLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAE 50
K KKK D++ KEK KKA+ A+T++ +P + + + + AE
Sbjct: 1401 KKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAE 1447
Score = 33.1 bits (74), Expect = 0.20
Identities = 34/146 (23%), Positives = 55/146 (37%), Gaps = 6/146 (4%)
Query: 50 EAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQA 109
E+++ K DQ A K+ +K A EA PEKT ++ KA+ KA +
Sbjct: 1305 ESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEA-SVSPEKTSTTSKGKAKRDKASGDVKE 1363
Query: 110 APGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS-----KEEGEPKKTEAPAAPAAQETKS 164
G + G E + G + S KE+ + K + ++ K+
Sbjct: 1364 KKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKA 1423
Query: 165 DGAPASDSKPGSSEAAPSSKETPAAT 190
A DS+ S + K+T T
Sbjct: 1424 KKASTKDSESPSQKKKKKKKKTAEQT 1449
Score = 31.2 bits (69), Expect = 0.76
Identities = 27/106 (25%), Positives = 47/106 (44%), Gaps = 8/106 (7%)
Query: 3 GKLSKKKKGYNVNDEKAKEKDKKAEGAATE-EEGTPKESEPQAAAEPAEAKEGKEKPDQD 61
GK + K +V ++K K ++GA E EE K + + K KEK D
Sbjct: 1350 GKAKRDKASGDVKEKKGKGS-LGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSD 1408
Query: 62 AEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQE 107
K +EK+ + K++A KA + +E ++ K + K ++
Sbjct: 1409 KRKKDKEKKEK------KKKAKKASTKDSESPSQKKKKKKKKTAEQ 1448
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 73.9 bits (180), Expect = 1e-13
Identities = 63/206 (30%), Positives = 94/206 (45%), Gaps = 12/206 (5%)
Query: 18 KAKEKDKKAEGAATEEEGTP-KESEP----QAAAEPAEAKEGKEKPDQDAEGKAEE-KEG 71
KA EK + A+ +GTP K + P +A A ++ K GK P++D+E +EE +
Sbjct: 292 KASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGK--PEEDSESSSEESSDS 349
Query: 72 EKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAE 131
E++ AAK KT A A P K ++ AAP P G P A+A A E
Sbjct: 350 EEETPAAKALLQAKASGKTSQVGAASA-PAKESPRKGAAPAP-PGKTGPAVAKAQAGKRE 407
Query: 132 SAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATE 191
+ ++ EE EE P +A + A + ++ APA +S + AP K PAA +
Sbjct: 408 EDSQSSSEESDSEEEAP--AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 465
Query: 192 APSSTPKAQGPAASAEEPKPVEAPAA 217
+ ++S E EA AA
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAA 491
Score = 72.0 bits (175), Expect = 4e-13
Identities = 62/228 (27%), Positives = 90/228 (39%), Gaps = 30/228 (13%)
Query: 19 AKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKA----EEKEGEKD 74
+ +D + T+ EG P Q A KE + A GK + +G
Sbjct: 198 SSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGAL 257
Query: 75 AAAAKEEAPKAEPEKTEGAAEAKAEPP-------KAPE---QEQAAPGPAAGGEA----- 119
A + + P+ E E +E +E++ E P KA E Q +AA PA G
Sbjct: 258 PPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATP 317
Query: 120 --PKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDG---------AP 168
P A A A+ ++ P E S EE + E PAA A + K+ G AP
Sbjct: 318 APPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAP 377
Query: 169 ASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPA 216
A +S + AP K PA +A + + ++S E EAPA
Sbjct: 378 AKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPA 425
Score = 62.4 bits (150), Expect = 3e-10
Identities = 70/242 (28%), Positives = 96/242 (39%), Gaps = 52/242 (21%)
Query: 20 KEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAK 79
K K AE +A + E E A A AK G Q A+ +E+ D
Sbjct: 155 KSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQ-ADSSSEDTSSSSDETDV- 212
Query: 80 EEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEA-PKAAEAAAAPAESAAPAAG 138
E P +P + + ++ + E P +AAP P G+ P+ A PA+ A
Sbjct: 213 EGKPSVKPAQVKASSVSTKESPA----RKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEE 268
Query: 139 EEPSKEEGEPKKTEAPA-------------------APA-------------------AQ 160
E S EEG + EAPA APA A
Sbjct: 269 ESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVAS 328
Query: 161 ETKSDGAPASDSKPGSSEAAPSSKETPAA---TEAPSSTPKAQGPAASA---EEPKPVEA 214
+TK+ G P DS+ S E++ S +ETPAA +A +S +Q AASA E P+ A
Sbjct: 329 QTKA-GKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387
Query: 215 PA 216
PA
Sbjct: 388 PA 389
Score = 59.7 bits (143), Expect = 2e-09
Identities = 57/220 (25%), Positives = 89/220 (40%), Gaps = 30/220 (13%)
Query: 9 KKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEE 68
K G V KA +K+ + ++EEE +E AAA PA+ K +K A A
Sbjct: 746 KTGPTVTQVKA---EKQEDSESSEEESDSEE----AAASPAQVKTSVKKTQAKANPAAAR 798
Query: 69 KEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQA-APGPAA----GGEAPKAA 123
K +A + A + + + P + P+ A GPA+ G AA
Sbjct: 799 APSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAA 858
Query: 124 EAAAAPAESAAPAAGEEPSKEE----------GEPKKTEAPAAPAAQETKSDGAPASDSK 173
+A P E + + E S+EE G+ + A APA + + AP K
Sbjct: 859 QAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGK 918
Query: 174 PGSS--------EAAPSSKETPAATEAPSSTPKAQGPAAS 205
G S ++ SS+E+ + EAP++ AQ +S
Sbjct: 919 TGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQDQESS 958
Score = 54.3 bits (129), Expect = 8e-08
Identities = 61/208 (29%), Positives = 91/208 (43%), Gaps = 34/208 (16%)
Query: 2 GGKLSKKKKGYNVNDEKAK-------EKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEG 54
G S+ K G D ++ E++ A A + + + K S+ AA+ PA
Sbjct: 324 GAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPA----- 378
Query: 55 KEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPA 114
KE P +G A G+ A AK +A K E + + E+ +E E+A
Sbjct: 379 KESP---RKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE-------EEAPAQAK 428
Query: 115 AGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKP 174
G+AP+ AA+APA+ +P G P+ P+KT PAA Q K + DS+
Sbjct: 429 PSGKAPQ-VRAASAPAKE-SPRKGAAPA----PPRKT-GPAAAQVQVGKQE----EDSR- 476
Query: 175 GSSEAAPSSKETPAATEAPSSTPKAQGP 202
SSE + S +E AA A P + P
Sbjct: 477 SSSEESDSDREALAAMNAAQVKPLGKSP 504
Score = 50.1 bits (118), Expect = 2e-06
Identities = 59/238 (24%), Positives = 90/238 (37%), Gaps = 44/238 (18%)
Query: 18 KAKEKDKKAEGAATEEEGTPKESE---PQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKD 74
KA K + A+ + +P++ P PA AK K ++D++ +EE + E++
Sbjct: 363 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEE 422
Query: 75 AAAAKEEAPKAEPEKTEGAAEAKAEPPK-APEQEQAAPGPAAGG---------------E 118
A A + + KA P+ +A AK P K A GPAA E
Sbjct: 423 APAQAKPSGKA-PQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEE 481
Query: 119 APKAAEAAAAPAESAAPAAGEEPSKEEGE--------------PKKTEAPAAPAAQETKS 164
+ EA AA + G+ P + P PA P+AQ K
Sbjct: 482 SDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKW 541
Query: 165 DGAPASDSKPGSSEAAPSSK-ETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQ 221
+ DS+ S E++ SS E P A P + + + KP +PA Q
Sbjct: 542 E----EDSESSSEESSDSSDGEVPTAV-----APAQEKSLGNILQAKPTSSPAKGPPQ 590
Score = 48.1 bits (113), Expect = 6e-06
Identities = 52/210 (24%), Positives = 83/210 (39%), Gaps = 23/210 (10%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEG--EKDAAAAKEEA----------P 83
+P + PQ A P + EKP ++E E + ++A AA A
Sbjct: 583 SPAKGPPQKAG-PVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQT 641
Query: 84 KAEPEKTEGAAEAKAEP----PKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGE 139
KA P+KT A AK P +AP + A PA G +P A PAE ++ +
Sbjct: 642 KACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA--GSSPAVAGGTQRPAEDSSSSEES 699
Query: 140 EPSKEEGEPKKT--EAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTP 197
+ +E+ T +A + + K+ P S + K P T+ +
Sbjct: 700 DSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAE-- 757
Query: 198 KAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
K + +S EE EA A+ + +VK+
Sbjct: 758 KQEDSESSEEESDSEEAAASPAQVKTSVKK 787
Score = 47.4 bits (111), Expect = 1e-05
Identities = 57/252 (22%), Positives = 96/252 (38%), Gaps = 50/252 (19%)
Query: 2 GGKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEK---- 57
G ++K + G D ++ ++ +E A + P PQ A A AKE K
Sbjct: 395 GPAVAKAQAGKREEDSQSSSEESDSEEEAPAQ-AKPSGKAPQVRAASAPAKESPRKGAAP 453
Query: 58 -----------------PDQDAEGKAEEKEGEKDAAAAKEEA--------PKAEPEKTEG 92
++D+ +EE + +++A AA A P+ +P T G
Sbjct: 454 APPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMG 513
Query: 93 AAE-AKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS-------KE 144
K P P + A A G+ + +E+++ ES+ + GE P+ K
Sbjct: 514 MGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSE--ESSDSSDGEVPTAVAPAQEKS 571
Query: 145 EG---EPKKTEAPA-------APAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPS 194
G + K T +PA P A + K++ + S + S+E PAA A
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQ 631
Query: 195 STPKAQGPAASA 206
+ P + P A
Sbjct: 632 AKPALKIPQTKA 643
Score = 47.4 bits (111), Expect = 1e-05
Identities = 49/187 (26%), Positives = 85/187 (45%), Gaps = 18/187 (9%)
Query: 44 AAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKA 103
A + PA A G ++P +D+ +EE + E++ +A+ +A + P K
Sbjct: 676 AGSSPAVAG-GTQRPAEDSSS-SEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG 733
Query: 104 PEQEQAAP------GPAAGG-EAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAA 156
+ AP GP +A K ++ ++ ES + A P++ + KKT+A A
Sbjct: 734 SLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKAN 793
Query: 157 PAAQETKSDGAPASDSKPGS--SEAAPSSKETPAATEAP-----SSTPKAQGPAASAEEP 209
PAA ++ A + S PG + AA + + +P+ + P +ST A+GPA+
Sbjct: 794 PAA--ARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVG 851
Query: 210 KPVEAPA 216
K V A
Sbjct: 852 KAVATAA 858
Score = 45.1 bits (105), Expect = 5e-05
Identities = 44/211 (20%), Positives = 78/211 (36%), Gaps = 5/211 (2%)
Query: 14 VNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEG-KEKPDQDAEGKAEEKEGE 72
++ ++ E++++AE A + TP+ + ++ A+ KEK + E +
Sbjct: 82 ISTSESSEEEEEAE--AETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSM 139
Query: 73 KDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEA-PKAAEAAAAPAE 131
A K A + +AE A E E+ PA G A P A A +
Sbjct: 140 PHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSS 199
Query: 132 SAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGS-SEAAPSSKETPAAT 190
S ++ + + EG+P A ++ TK A + PG + P K
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPP 259
Query: 191 EAPSSTPKAQGPAASAEEPKPVEAPAANSDQ 221
+ P+ + ++ EAPA Q
Sbjct: 260 AKRAKKPEEESESSEEGSESEEEAPAGTRSQ 290
Score = 44.3 bits (103), Expect = 9e-05
Identities = 57/224 (25%), Positives = 90/224 (40%), Gaps = 52/224 (23%)
Query: 22 KDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEE 81
+ +KAE A + + S+P + +E +E +E E KA + +++ +
Sbjct: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAET----AKATPRLASTNSSVLGAD 116
Query: 82 APKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEP 141
P + EK AKAE KA + + P PA G + A +P EP
Sbjct: 117 LPSSMKEK------AKAETEKAGKTGNSMPHPATG-------KTVANLLSGKSPRKSAEP 163
Query: 142 S---------KEEGEPKKTEAPAAPA------AQETKSDGAPASDS---------KPGSS 177
S +EEG A A P A + D + +SD KP
Sbjct: 164 SANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQV 223
Query: 178 EAAP-SSKETPAATEAPSS------TPKAQG----PAASAEEPK 210
+A+ S+KE+PA AP+ TP+ +G PA A++P+
Sbjct: 224 KASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPE 267
Score = 40.0 bits (92), Expect = 0.002
Identities = 46/215 (21%), Positives = 92/215 (42%), Gaps = 13/215 (6%)
Query: 15 NDEKAKEKDKKAEGAAT--EEEGTPKESEPQAAAEPAEAKEGKEK----PDQDAEGKAEE 68
+ E++ +++K A T + + K + +AA+ P + G+ P + +
Sbjct: 695 SSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQV 754
Query: 69 K-EGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGG--EAPKAAEA 125
K E ++D+ +++EE+ E + + + +A AA P+A G AP
Sbjct: 755 KAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVT 814
Query: 126 AAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDG-APASDSKPGSSEAAPSSK 184
AAA A+ +P+ + P + T PA+ + A A+ ++ G E + SS+
Sbjct: 815 AAAQAKQRSPSKVKPPVR--NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSE 872
Query: 185 ETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANS 219
E + E + + + P+ + + APA S
Sbjct: 873 EESDSEEEAETLAQVK-PSGKTHQIRAALAPAKES 906
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 73.6 bits (179), Expect = 1e-13
Identities = 51/182 (28%), Positives = 78/182 (42%), Gaps = 8/182 (4%)
Query: 7 KKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGK-EKPDQDAEGK 65
+KK+ +EK +E+ + EG E EG +E E E E +EGK E+ +++ EG+
Sbjct: 775 RKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGE 834
Query: 66 AEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQ--EQAAPGPAAGGEAPKAA 123
EE+EGE +EE + E E+ EG E + E + E+ E G GE
Sbjct: 835 GEEEEGE-----GEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEE 889
Query: 124 EAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSS 183
E E GEE + EGE ++ E +E + +G G
Sbjct: 890 EGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGE 949
Query: 184 KE 185
+E
Sbjct: 950 EE 951
Score = 64.7 bits (156), Expect = 6e-11
Identities = 54/209 (25%), Positives = 84/209 (40%), Gaps = 15/209 (7%)
Query: 10 KGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAK------EGK-EKPDQDA 62
+G V + K + ++++ EG EEEG +E E + E E K EG+ E+ ++
Sbjct: 815 EGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEG 874
Query: 63 EGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQA-APGPAAG--GEA 119
EG+ EE+EGE + EE + E E+ EG E + E E+E+ G G GE
Sbjct: 875 EGEGEEEEGEGEG----EEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEG 930
Query: 120 PKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEA 179
E E EE + EGE ++ E + +G + + G E
Sbjct: 931 EGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEG 990
Query: 180 APSSKETPAATEAPSSTPKAQGPAASAEE 208
E E + +G EE
Sbjct: 991 EEEEGEEEGEEEG-EGEEEGEGEGEEEEE 1018
Score = 60.5 bits (145), Expect = 1e-09
Identities = 52/194 (26%), Positives = 79/194 (40%), Gaps = 12/194 (6%)
Query: 20 KEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPD---QDAEGKAEEKEGE--KD 74
KE++++ E EE G +E E E E KEG+ K + ++ EG+ E++EGE K+
Sbjct: 721 KERNQEMEEGGEEEHGEGEEEEGDREEE--EEKEGEGKEEGEGEEVEGEREKEEGERKKE 778
Query: 75 AAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAA 134
A KEE K E E +G E + + E+E+ G GGE + + E
Sbjct: 779 ERAGKEE--KGEEEGDQGEGEEEETEGRGEEKEEG--GEVEGGEV-EEGKGEREEEEEEG 833
Query: 135 PAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPS 194
EE EE E + E +E +G + + G E E E
Sbjct: 834 EGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEG 893
Query: 195 STPKAQGPAASAEE 208
+ +G EE
Sbjct: 894 EGEEEEGEGEGEEE 907
Score = 60.5 bits (145), Expect = 1e-09
Identities = 46/186 (24%), Positives = 78/186 (41%), Gaps = 15/186 (8%)
Query: 3 GKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPK----------ESEPQAAAEPAEAK 52
GK ++++ E+ + + ++ EG EEEG K E E + E +
Sbjct: 822 GKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEE 881
Query: 53 EGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPG 112
EG+ + +++ EG+ EE+EGE + +E + E E+ EG E + E + +E+ G
Sbjct: 882 EGEGEGEEEGEGEGEEEEGEGE--GEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEG 939
Query: 113 PAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDS 172
GE E E GE +EEGE + E +E + +G
Sbjct: 940 EGEDGEGEGEEEEGEWEGEE---EEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGE 996
Query: 173 KPGSSE 178
+ G E
Sbjct: 997 EEGEEE 1002
Score = 59.3 bits (142), Expect = 3e-09
Identities = 46/193 (23%), Positives = 80/193 (41%), Gaps = 14/193 (7%)
Query: 7 KKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAE---PAEAKEGKEKPDQDAE 63
++++G +E+ +E + + EG E EG +E E + E E +EG+ + +++ E
Sbjct: 850 EEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGE 909
Query: 64 GKAEEKEGE--------KDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAA 115
G+ EE+EGE + +EE + E E EG E + + E+E G
Sbjct: 910 GEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEE 969
Query: 116 GGEAPKAAEAAAAPAESAAPA---AGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDS 172
G + E E GEE +EEGE ++ +E + +G +
Sbjct: 970 GEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEE 1029
Query: 173 KPGSSEAAPSSKE 185
G E +E
Sbjct: 1030 GEGEGEEEEGEEE 1042
Score = 58.9 bits (141), Expect = 3e-09
Identities = 55/211 (26%), Positives = 84/211 (39%), Gaps = 8/211 (3%)
Query: 3 GKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDA 62
G+ ++ +G +E E +++ EG EEEG K E E +E E +D
Sbjct: 885 GEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDG 944
Query: 63 EGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKA 122
EG+ EE+EGE + +EE + E E+ EG E + + E+E G GE +
Sbjct: 945 EGEGEEEEGEWE---GEEEEGEGEGEE-EGEGEGEEGEGEGEEEEGEGEGEEEEGE-EEG 999
Query: 123 AEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPS 182
E E EE + EGE + E +E + +G K G E
Sbjct: 1000 EEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEG--EEREKEGEGEENRR 1057
Query: 183 SKETPAATEAP-SSTPKAQGPAASAEEPKPV 212
++E E T + + EE K V
Sbjct: 1058 NREEEEEEEGKYQETGEEENERQDGEEYKKV 1088
Score = 57.4 bits (137), Expect = 1e-08
Identities = 50/200 (25%), Positives = 78/200 (39%), Gaps = 9/200 (4%)
Query: 16 DEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKE--GKEKPDQDAEGKAEEKEG-- 71
+E+ KE + K EG E EG ++ E + E KE G+E+ DQ EG+ EE EG
Sbjct: 747 EEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQ-GEGEEEETEGRG 805
Query: 72 -EKDAAAAKE--EAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAA 128
EK+ E E + + E+ E E + E + +E+ G GE E
Sbjct: 806 EEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEG 865
Query: 129 PAESAAPAAGEEPSKEEGEPK-KTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETP 187
E E +EEGE + + E +E + +G + + E +E
Sbjct: 866 EGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEG 925
Query: 188 AATEAPSSTPKAQGPAASAE 207
E + +G E
Sbjct: 926 EEGEGEGEEEEGEGEGEDGE 945
Score = 50.1 bits (118), Expect = 2e-06
Identities = 52/204 (25%), Positives = 78/204 (38%), Gaps = 15/204 (7%)
Query: 18 KAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAA 77
+ +E++ + EG E EG +E E + E E + +E + EG+ E +E E +
Sbjct: 931 EGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEG 990
Query: 78 AKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAA 137
+EE + E+ EG E + E + E+E G G E E E
Sbjct: 991 EEEEGEEEGEEEGEGEEEGEGEGEE--EEEGEVEGEVEGEEGEGEGE------EEEGEEE 1042
Query: 138 GEEPSKE-EGEP----KKTEAPAAPAAQETKSDGAPASDSKPGS--SEAAPSSKETPAAT 190
GEE KE EGE ++ E QET + D + S+ S K T
Sbjct: 1043 GEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKT 1102
Query: 191 EAPSSTPKAQGPAASAEEPKPVEA 214
S QG PV++
Sbjct: 1103 YQKKSVTNTQGNGKEQRSKMPVQS 1126
Score = 48.5 bits (114), Expect = 5e-06
Identities = 51/215 (23%), Positives = 77/215 (35%), Gaps = 9/215 (4%)
Query: 15 NDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEG-KEKPD---QDAEGKAEEKE 70
+DE+ + ++K EGA + +E E +A E + G KEK + D KAE E
Sbjct: 580 SDEEVEIPEEK-EGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSE 638
Query: 71 GEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGG-EAPKAAEAAAAP 129
G+ + E+ P+ + T + AE + E+E+ G E P E A
Sbjct: 639 GKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAE 698
Query: 130 AESAAPAAGEE---PSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKET 186
E GEE +E+G K+ +E +G + E KE
Sbjct: 699 KEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEE 758
Query: 187 PAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQ 221
E K +G E E DQ
Sbjct: 759 GEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQ 793
Score = 43.5 bits (101), Expect = 1e-04
Identities = 47/220 (21%), Positives = 79/220 (35%), Gaps = 28/220 (12%)
Query: 16 DEKAKEKDKKAEGA---ATEEEGTPKESEPQAAAEPAEAKEGKEKPD------QDAEGKA 66
D+ E ++ EG A +EE ++ E Q E + + KE+ ++ G+
Sbjct: 680 DKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQ-KERNQEMEEGGEEEHGEG 738
Query: 67 EEKEGEKDAAAAKE-------EAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEA 119
EE+EG+++ KE E + E E+ + E K E E++ G GE
Sbjct: 739 EEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEE 798
Query: 120 PKAAEAAAAPAESAAPAAGE--------EPSKEEGEPKKTEAPAAP---AAQETKSDGAP 168
+ E GE E +EEGE ++ E +E + +G
Sbjct: 799 EETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKG 858
Query: 169 ASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEE 208
+ + G E E E + +G EE
Sbjct: 859 EEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEE 898
Score = 41.2 bits (95), Expect = 7e-04
Identities = 28/108 (25%), Positives = 51/108 (47%), Gaps = 4/108 (3%)
Query: 7 KKKKGYNVNDEKAKEKDKKAEGAATEE-EGTPKESEPQAAAEPAEAKEGK---EKPDQDA 62
++++G +E+ E++ + EG EE EG +E E E +EG+ E+ + +
Sbjct: 982 EEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEE 1041
Query: 63 EGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAA 110
EG+ EKEGE + E + E K + E + E E ++ +
Sbjct: 1042 EGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVS 1089
Score = 38.9 bits (89), Expect = 0.004
Identities = 47/201 (23%), Positives = 74/201 (36%), Gaps = 22/201 (10%)
Query: 14 VNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAE-EKEGE 72
V++ KAK + +G +GT +E A E +E EK +G+ E E+ GE
Sbjct: 636 VSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKD----KGRGEMERPGE 691
Query: 73 KDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAES 132
+ KE A K E +K +G + + E + ++E+ G E E E
Sbjct: 692 GE----KELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREE 747
Query: 133 AAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEA 192
GE + EGE + E K +G + + G E K +
Sbjct: 748 EEEKEGEGKEEGEGEEVEGE--------REKEEGERKKEERAGKEE-----KGEEEGDQG 794
Query: 193 PSSTPKAQGPAASAEEPKPVE 213
+ +G EE VE
Sbjct: 795 EGEEEETEGRGEEKEEGGEVE 815
Score = 33.5 bits (75), Expect = 0.15
Identities = 35/166 (21%), Positives = 59/166 (35%), Gaps = 9/166 (5%)
Query: 20 KEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAK 79
K+K ++ G T++ + + E +E KEGK ++G + A +
Sbjct: 522 KQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSD 581
Query: 80 EEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEA-------AAAPAES 132
EE PE+ EGA ++K + E E G + E A +E
Sbjct: 582 EEV--EIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEG 639
Query: 133 AAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSE 178
A + GE EG T + A+ + + + G E
Sbjct: 640 KAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGE 685
Score = 30.8 bits (68), Expect = 0.99
Identities = 21/82 (25%), Positives = 41/82 (50%), Gaps = 2/82 (2%)
Query: 17 EKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGE-KDA 75
E +E++ + EG EEG E E + E E +E + + +++ + EE+E E K
Sbjct: 1012 EGEEEEEGEVEGEVEGEEG-EGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQ 1070
Query: 76 AAAKEEAPKAEPEKTEGAAEAK 97
+EE + + E+ + ++ K
Sbjct: 1071 ETGEEENERQDGEEYKKVSKIK 1092
>gi|33286446 opioid growth factor receptor [Homo sapiens]
Length = 677
Score = 67.8 bits (164), Expect = 7e-12
Identities = 64/234 (27%), Positives = 92/234 (39%), Gaps = 23/234 (9%)
Query: 1 MGGKLSKKKKGYNVNDEKAKEKDKKAEGAATE--------EEGTPKESEPQAAAEPAEAK 52
+G +++ K + DE A + A G A G PK + E E
Sbjct: 447 LGARVADKVRKRRKVDEGAGDSAAVASGGAQTLALAGSPAPSGHPKAGHSENGVE--EDT 504
Query: 53 EGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEG---AAEAKAEPPKAPEQEQA 109
EG+ P + G E G A A +E P P +T G A A EP ++P +
Sbjct: 505 EGRTGPKEGTPGSPSETPGPSPAGPAGDE-PAESPSETPGPRPAGPAGDEPAESPSE--- 560
Query: 110 APGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPA 169
PGP G P E A +P+E+ P+ P+++E +E P A + A +
Sbjct: 561 TPGPRPAG--PAGDEPAESPSETPGPSPAG-PTRDEPAESPSETPGPRPAGPAGDEPAES 617
Query: 170 SDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTV 223
PG A P+ E PA E+PS TP + +EP A D V
Sbjct: 618 PSETPGPRPAGPAGDE-PA--ESPSETPGPSPAGPTRDEPAKAGEAAELQDAEV 668
Score = 50.8 bits (120), Expect = 9e-07
Identities = 53/189 (28%), Positives = 72/189 (38%), Gaps = 26/189 (13%)
Query: 15 NDEKAKEKDKKAEGAATEEEGTPKESEPQ--------AAAEPAEAKEGKEKP-------D 59
+ E E+D EG +EGTP A EPAE+ P D
Sbjct: 495 HSENGVEED--TEGRTGPKEGTPGSPSETPGPSPAGPAGDEPAESPSETPGPRPAGPAGD 552
Query: 60 QDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEA 119
+ AE +E G + A A +E P P +T G + A + E PGP G
Sbjct: 553 EPAESPSETP-GPRPAGPAGDE-PAESPSETPGPSPAGPTRDEPAESPSETPGPRPAG-- 608
Query: 120 PKAAEAAAAPAESAAP----AAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPG 175
P E A +P+E+ P AG+EP++ E +PA P E G A
Sbjct: 609 PAGDEPAESPSETPGPRPAGPAGDEPAESPSE-TPGPSPAGPTRDEPAKAGEAAELQDAE 667
Query: 176 SSEAAPSSK 184
+A S K
Sbjct: 668 VESSAKSGK 676
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 67.8 bits (164), Expect = 7e-12
Identities = 60/227 (26%), Positives = 96/227 (42%), Gaps = 17/227 (7%)
Query: 16 DEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEK-- 73
++K ++K+ E A EEE K+S +A A + +EG+++ ++ E + EE EG K
Sbjct: 487 EKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSD 546
Query: 74 ---DAAAAKE-EAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAP 129
+ + KE + K E E+ EG EA+AE +A +E+ + A K A A
Sbjct: 547 QAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAK 606
Query: 130 AESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKE---- 185
E A P E K+ P +P ++ KS + + G S S E
Sbjct: 607 VEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGK 666
Query: 186 -----TPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
+P +A S PK+ P A+ V ++ VKE
Sbjct: 667 SPVSKSPVEEKAKSPVPKS--PVEEAKSKAEVGKGEQKEEEEKEVKE 711
Score = 65.1 bits (157), Expect = 5e-11
Identities = 54/204 (26%), Positives = 91/204 (44%), Gaps = 14/204 (6%)
Query: 14 VNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEP----AEAKEGKEKPDQDAEGKAEEK 69
+ +E A ++ + AA E+E P+ E + AA+ A A E KE+ + E + +E+
Sbjct: 476 ITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEE 535
Query: 70 EGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPK----AAEA 125
E E+D A ++A + EK EG++E + + E E A G A + K +E
Sbjct: 536 EEEEDEGAKSDQAEEGGSEK-EGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEE 594
Query: 126 AAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKE 185
A E A A E+P K K+ P +P ++ KS + + G S S E
Sbjct: 595 VATKEELVADAKVEKPEK-----AKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVE 649
Query: 186 TPAATEAPSSTPKAQGPAASAEEP 209
+ P S + +G + ++ P
Sbjct: 650 EKGKSPVPKSPVEEKGKSPVSKSP 673
Score = 65.1 bits (157), Expect = 5e-11
Identities = 60/212 (28%), Positives = 89/212 (41%), Gaps = 39/212 (18%)
Query: 24 KKAEGAATEEEGTPKESEPQAAAEPAEAKEG-KEKPDQDAEGKAEEKEGEKDAAAAKEEA 82
K+ EG EEEG +E E A+ +A+EG EK + + E++EGE +A A EEA
Sbjct: 521 KEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEA 580
Query: 83 PKAEPEKTEGAAE-------------------AKAEPPKAPEQEQAAPGPAAGGEAPKAA 123
E +K E +E AK+ PK+P +E+ G++P
Sbjct: 581 EAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEK--------GKSPVPK 632
Query: 124 EAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSS 183
+S P + P +E+G K+ P +P ++ KS P S S +P
Sbjct: 633 SPVEEKGKSPVP---KSPVEEKG---KSPVPKSPVEEKGKS---PVSKSPVEEKAKSPVP 683
Query: 184 KETPAATEAPSSTPKAQGPAASAEEPKPVEAP 215
K EA S +G EE + EAP
Sbjct: 684 KS--PVEEAKSKAEVGKGEQKEEEEKEVKEAP 713
Score = 60.8 bits (146), Expect = 9e-10
Identities = 57/221 (25%), Positives = 96/221 (43%), Gaps = 16/221 (7%)
Query: 16 DEKAKEKDKKAEGAATEEEGTPK--------ESEPQAAAEPAEAKEGKEKPDQDAEGKAE 67
DE AK D+ EG + +E + K E+E +A E AEAKE K K ++ +E A
Sbjct: 540 DEGAKS-DQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEK-KVEEKSEEVAT 597
Query: 68 EKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQA-APGPAAGGEAPKAAEAA 126
++E DA K E K+ K+ + K+ PK+P +E+ +P P + E +
Sbjct: 598 KEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVP 657
Query: 127 AAPAESAAPA-AGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKE 185
+P E + + P +E+ + ++P A + + + + + AP ++
Sbjct: 658 KSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEK 717
Query: 186 TPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVK 226
E P P+ + AE P EA A T +VK
Sbjct: 718 VEKKEEKPKDVPEKK----KAESPVKEEAVAEVVTITKSVK 754
Score = 59.3 bits (142), Expect = 3e-09
Identities = 48/167 (28%), Positives = 78/167 (46%), Gaps = 27/167 (16%)
Query: 63 EGKAEEKEGEKDAA--AAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAP 120
E K E+++ E + A A EE + E+ + AAE K E P+A E+E A
Sbjct: 459 ETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVA----------- 507
Query: 121 KAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAA 180
A +P ++ AP EE ++E E + E +E + +GA + ++ G SE
Sbjct: 508 ----AKKSPVKATAPEVKEEEGEKEEEEGQEE-------EEEEDEGAKSDQAEEGGSEKE 556
Query: 181 PSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
SS++ E + +A+G A A+E K VE S++ T +E
Sbjct: 557 GSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVE---EKSEEVATKEE 600
Score = 56.6 bits (135), Expect = 2e-08
Identities = 58/241 (24%), Positives = 99/241 (41%), Gaps = 33/241 (13%)
Query: 3 GKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAE--PAEAKEGKE---- 56
G+ ++++ ++A+E + EG++ +EEG +E E +A AE AEAKE K+
Sbjct: 532 GQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEK 591
Query: 57 ------KPDQDAEGKAEEKEGEKDAAAAK---------------EEAPKAEPEKTEGAAE 95
K + A+ K E+ E K EE K+ K+ +
Sbjct: 592 SEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEK 651
Query: 96 AKAEPPKAPEQEQA-APGPAAGGEAPKAAEAAAAPAESAAPAA--GEEPSKEEGEPKKTE 152
K+ PK+P +E+ +P + E + +P E A A G+ KEE E + E
Sbjct: 652 GKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKE 711
Query: 153 APAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPV 212
AP ++ + + K S P +E A + + K + EE KP+
Sbjct: 712 APKEEKVEKKEEKPKDVPEKKKAES---PVKEEAVAEVVTITKSVKVHLEKETKEEGKPL 768
Query: 213 E 213
+
Sbjct: 769 Q 769
Score = 53.5 bits (127), Expect = 1e-07
Identities = 58/216 (26%), Positives = 88/216 (40%), Gaps = 18/216 (8%)
Query: 5 LSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAE---AKEGKEKPDQD 61
+S K + V K K + K E E + ++SE + A A KE+ +
Sbjct: 432 ISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEA 491
Query: 62 AEGKAEEKEGEKDAAAAKEEAPKAE-PEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAP 120
AE K EE E E++ AAK+ KA PE E E + E + E+E+ E
Sbjct: 492 AEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEE--------DEGA 543
Query: 121 KAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSE-- 178
K+ +A +E + EE +EEGE TEA A E K + S+ +++
Sbjct: 544 KSDQAEEGGSEKEGSSEKEEGEQEEGE---TEAEAEGEEAEAKEEKKVEEKSEEVATKEE 600
Query: 179 -AAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVE 213
A + E P ++P + S PVE
Sbjct: 601 LVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVE 636
Score = 46.2 bits (108), Expect = 2e-05
Identities = 50/187 (26%), Positives = 75/187 (40%), Gaps = 34/187 (18%)
Query: 16 DEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEK--------PDQDAEGKAE 67
+EK K K+ + PK + P +EK P ++A+ KAE
Sbjct: 636 EEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAE 695
Query: 68 EKEGEKDAAAAKE--EAPKAEPEKTEGAAEAKAEPPK-APEQEQAAPGPAAGGEAPKAAE 124
+GE+ KE EAPK E E K E PK PE+++A E+P E
Sbjct: 696 VGKGEQKEEEEKEVKEAPKEEK------VEKKEEKPKDVPEKKKA--------ESPVKEE 741
Query: 125 AAA--APAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPS 182
A A + E+ +KEEG+P + E +E + G + GS + A
Sbjct: 742 AVAEVVTITKSVKVHLEKETKEEGKPLQQE-------KEKEKAGGEGGSEEEGSDKGAKG 794
Query: 183 SKETPAA 189
S++ A
Sbjct: 795 SRKEDIA 801
Score = 44.7 bits (104), Expect = 7e-05
Identities = 55/249 (22%), Positives = 88/249 (35%), Gaps = 34/249 (13%)
Query: 8 KKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAE 67
++KG + + E+ K+ + + E K P++ E A++K K +Q E + E
Sbjct: 649 EEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKE 708
Query: 68 EKEGEKDAAAAK-EEAPKAEPEKTEGAAEAKAEP------------------------PK 102
KE K+ K EE PK PEK + + K E P
Sbjct: 709 VKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPL 768
Query: 103 APEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQE- 161
E+E+ G G E + + A + GE KEE E + E + ++
Sbjct: 769 QQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKG 828
Query: 162 ---TKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAAN 218
D +PA + K G S+E T+ G A+ K V
Sbjct: 829 VVTNGLDLSPADEKKGGD-----KSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKV 883
Query: 219 SDQTVTVKE 227
+ T +E
Sbjct: 884 EEHEETFEE 892
Score = 38.1 bits (87), Expect = 0.006
Identities = 30/113 (26%), Positives = 50/113 (44%), Gaps = 2/113 (1%)
Query: 5 LSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPA--EAKEGKEKPDQDA 62
L K+ K ++ KEK+K +EEEG+ K ++ + A EGKE+ +Q+
Sbjct: 757 LEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQET 816
Query: 63 EGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAA 115
+ K +E EK + A+ +K +E K K E+ + G A
Sbjct: 817 KEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGA 869
Score = 36.6 bits (83), Expect = 0.018
Identities = 28/107 (26%), Positives = 41/107 (38%), Gaps = 16/107 (14%)
Query: 7 KKKKGYNVNDEKAKEKDKKAEGAA----------------TEEEGTPKESEPQAAAEPAE 50
K++K +V ++K E K E A T+EEG P + E + E
Sbjct: 721 KEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGE 780
Query: 51 AKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAK 97
+E D+ A+G +E KEE + EK G E K
Sbjct: 781 GGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEK 827
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 67.8 bits (164), Expect = 7e-12
Identities = 60/227 (26%), Positives = 96/227 (42%), Gaps = 17/227 (7%)
Query: 16 DEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEK-- 73
++K ++K+ E A EEE K+S +A A + +EG+++ ++ E + EE EG K
Sbjct: 111 EKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSD 170
Query: 74 ---DAAAAKE-EAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAP 129
+ + KE + K E E+ EG EA+AE +A +E+ + A K A A
Sbjct: 171 QAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAK 230
Query: 130 AESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKE---- 185
E A P E K+ P +P ++ KS + + G S S E
Sbjct: 231 VEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGK 290
Query: 186 -----TPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
+P +A S PK+ P A+ V ++ VKE
Sbjct: 291 SPVSKSPVEEKAKSPVPKS--PVEEAKSKAEVGKGEQKEEEEKEVKE 335
Score = 65.1 bits (157), Expect = 5e-11
Identities = 54/204 (26%), Positives = 91/204 (44%), Gaps = 14/204 (6%)
Query: 14 VNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEP----AEAKEGKEKPDQDAEGKAEEK 69
+ +E A ++ + AA E+E P+ E + AA+ A A E KE+ + E + +E+
Sbjct: 100 ITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEE 159
Query: 70 EGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPK----AAEA 125
E E+D A ++A + EK EG++E + + E E A G A + K +E
Sbjct: 160 EEEEDEGAKSDQAEEGGSEK-EGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEE 218
Query: 126 AAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKE 185
A E A A E+P K K+ P +P ++ KS + + G S S E
Sbjct: 219 VATKEELVADAKVEKPEK-----AKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVE 273
Query: 186 TPAATEAPSSTPKAQGPAASAEEP 209
+ P S + +G + ++ P
Sbjct: 274 EKGKSPVPKSPVEEKGKSPVSKSP 297
Score = 65.1 bits (157), Expect = 5e-11
Identities = 60/212 (28%), Positives = 89/212 (41%), Gaps = 39/212 (18%)
Query: 24 KKAEGAATEEEGTPKESEPQAAAEPAEAKEG-KEKPDQDAEGKAEEKEGEKDAAAAKEEA 82
K+ EG EEEG +E E A+ +A+EG EK + + E++EGE +A A EEA
Sbjct: 145 KEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEA 204
Query: 83 PKAEPEKTEGAAE-------------------AKAEPPKAPEQEQAAPGPAAGGEAPKAA 123
E +K E +E AK+ PK+P +E+ G++P
Sbjct: 205 EAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEK--------GKSPVPK 256
Query: 124 EAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSS 183
+S P + P +E+G K+ P +P ++ KS P S S +P
Sbjct: 257 SPVEEKGKSPVP---KSPVEEKG---KSPVPKSPVEEKGKS---PVSKSPVEEKAKSPVP 307
Query: 184 KETPAATEAPSSTPKAQGPAASAEEPKPVEAP 215
K EA S +G EE + EAP
Sbjct: 308 KS--PVEEAKSKAEVGKGEQKEEEEKEVKEAP 337
Score = 60.8 bits (146), Expect = 9e-10
Identities = 57/221 (25%), Positives = 96/221 (43%), Gaps = 16/221 (7%)
Query: 16 DEKAKEKDKKAEGAATEEEGTPK--------ESEPQAAAEPAEAKEGKEKPDQDAEGKAE 67
DE AK D+ EG + +E + K E+E +A E AEAKE K K ++ +E A
Sbjct: 164 DEGAKS-DQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEK-KVEEKSEEVAT 221
Query: 68 EKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQA-APGPAAGGEAPKAAEAA 126
++E DA K E K+ K+ + K+ PK+P +E+ +P P + E +
Sbjct: 222 KEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVP 281
Query: 127 AAPAESAAPA-AGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKE 185
+P E + + P +E+ + ++P A + + + + + AP ++
Sbjct: 282 KSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEK 341
Query: 186 TPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVK 226
E P P+ + AE P EA A T +VK
Sbjct: 342 VEKKEEKPKDVPEKK----KAESPVKEEAVAEVVTITKSVK 378
Score = 59.3 bits (142), Expect = 3e-09
Identities = 48/167 (28%), Positives = 78/167 (46%), Gaps = 27/167 (16%)
Query: 63 EGKAEEKEGEKDAA--AAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAP 120
E K E+++ E + A A EE + E+ + AAE K E P+A E+E A
Sbjct: 83 ETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVA----------- 131
Query: 121 KAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAA 180
A +P ++ AP EE ++E E + E +E + +GA + ++ G SE
Sbjct: 132 ----AKKSPVKATAPEVKEEEGEKEEEEGQEE-------EEEEDEGAKSDQAEEGGSEKE 180
Query: 181 PSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVKE 227
SS++ E + +A+G A A+E K VE S++ T +E
Sbjct: 181 GSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVE---EKSEEVATKEE 224
Score = 56.6 bits (135), Expect = 2e-08
Identities = 58/241 (24%), Positives = 99/241 (41%), Gaps = 33/241 (13%)
Query: 3 GKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAE--PAEAKEGKE---- 56
G+ ++++ ++A+E + EG++ +EEG +E E +A AE AEAKE K+
Sbjct: 156 GQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEK 215
Query: 57 ------KPDQDAEGKAEEKEGEKDAAAAK---------------EEAPKAEPEKTEGAAE 95
K + A+ K E+ E K EE K+ K+ +
Sbjct: 216 SEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEK 275
Query: 96 AKAEPPKAPEQEQA-APGPAAGGEAPKAAEAAAAPAESAAPAA--GEEPSKEEGEPKKTE 152
K+ PK+P +E+ +P + E + +P E A A G+ KEE E + E
Sbjct: 276 GKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKE 335
Query: 153 APAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPV 212
AP ++ + + K S P +E A + + K + EE KP+
Sbjct: 336 APKEEKVEKKEEKPKDVPEKKKAES---PVKEEAVAEVVTITKSVKVHLEKETKEEGKPL 392
Query: 213 E 213
+
Sbjct: 393 Q 393
Score = 53.5 bits (127), Expect = 1e-07
Identities = 58/216 (26%), Positives = 88/216 (40%), Gaps = 18/216 (8%)
Query: 5 LSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAE---AKEGKEKPDQD 61
+S K + V K K + K E E + ++SE + A A KE+ +
Sbjct: 56 ISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEA 115
Query: 62 AEGKAEEKEGEKDAAAAKEEAPKAE-PEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAP 120
AE K EE E E++ AAK+ KA PE E E + E + E+E+ E
Sbjct: 116 AEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEE--------DEGA 167
Query: 121 KAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSE-- 178
K+ +A +E + EE +EEGE TEA A E K + S+ +++
Sbjct: 168 KSDQAEEGGSEKEGSSEKEEGEQEEGE---TEAEAEGEEAEAKEEKKVEEKSEEVATKEE 224
Query: 179 -AAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVE 213
A + E P ++P + S PVE
Sbjct: 225 LVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVE 260
Score = 46.2 bits (108), Expect = 2e-05
Identities = 50/187 (26%), Positives = 75/187 (40%), Gaps = 34/187 (18%)
Query: 16 DEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEK--------PDQDAEGKAE 67
+EK K K+ + PK + P +EK P ++A+ KAE
Sbjct: 260 EEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAE 319
Query: 68 EKEGEKDAAAAKE--EAPKAEPEKTEGAAEAKAEPPK-APEQEQAAPGPAAGGEAPKAAE 124
+GE+ KE EAPK E E K E PK PE+++A E+P E
Sbjct: 320 VGKGEQKEEEEKEVKEAPKEEK------VEKKEEKPKDVPEKKKA--------ESPVKEE 365
Query: 125 AAA--APAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPS 182
A A + E+ +KEEG+P + E +E + G + GS + A
Sbjct: 366 AVAEVVTITKSVKVHLEKETKEEGKPLQQE-------KEKEKAGGEGGSEEEGSDKGAKG 418
Query: 183 SKETPAA 189
S++ A
Sbjct: 419 SRKEDIA 425
Score = 44.7 bits (104), Expect = 7e-05
Identities = 55/249 (22%), Positives = 88/249 (35%), Gaps = 34/249 (13%)
Query: 8 KKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAE 67
++KG + + E+ K+ + + E K P++ E A++K K +Q E + E
Sbjct: 273 EEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKE 332
Query: 68 EKEGEKDAAAAK-EEAPKAEPEKTEGAAEAKAEP------------------------PK 102
KE K+ K EE PK PEK + + K E P
Sbjct: 333 VKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPL 392
Query: 103 APEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQE- 161
E+E+ G G E + + A + GE KEE E + E + ++
Sbjct: 393 QQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKG 452
Query: 162 ---TKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAAN 218
D +PA + K G S+E T+ G A+ K V
Sbjct: 453 VVTNGLDLSPADEKKGGD-----KSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKV 507
Query: 219 SDQTVTVKE 227
+ T +E
Sbjct: 508 EEHEETFEE 516
Score = 38.1 bits (87), Expect = 0.006
Identities = 30/113 (26%), Positives = 50/113 (44%), Gaps = 2/113 (1%)
Query: 5 LSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPA--EAKEGKEKPDQDA 62
L K+ K ++ KEK+K +EEEG+ K ++ + A EGKE+ +Q+
Sbjct: 381 LEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQET 440
Query: 63 EGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAA 115
+ K +E EK + A+ +K +E K K E+ + G A
Sbjct: 441 KEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGA 493
Score = 36.6 bits (83), Expect = 0.018
Identities = 28/107 (26%), Positives = 41/107 (38%), Gaps = 16/107 (14%)
Query: 7 KKKKGYNVNDEKAKEKDKKAEGAA----------------TEEEGTPKESEPQAAAEPAE 50
K++K +V ++K E K E A T+EEG P + E + E
Sbjct: 345 KEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGE 404
Query: 51 AKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAK 97
+E D+ A+G +E KEE + EK G E K
Sbjct: 405 GGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEK 451
>gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo
sapiens]
Length = 2462
Score = 66.2 bits (160), Expect = 2e-11
Identities = 60/221 (27%), Positives = 87/221 (39%), Gaps = 16/221 (7%)
Query: 16 DEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDA 75
+ A+ K KKA AA+EE P E + E + +E+ ++AE +
Sbjct: 676 ERNARRKKKKAPAAASEEAAFPPVVEDEEM-EASGVSGNEEEMVEEAEATVNNSSDTESI 734
Query: 76 AAAKEEAPK------AEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAP 129
+ EA K +P T GA PP P ++ AP E A+EA AP
Sbjct: 735 PSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPT-----EPTPASEATGAP 789
Query: 130 AESAAPAAGEEPSKE-EGEPKKTEAPAAPAAQETKSDGAPASDS---KPGSSEAAPSSKE 185
AP + P E K+ E AAP +E + PA++ G +E S+
Sbjct: 790 TPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSEC 849
Query: 186 TPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVK 226
T A E P+ A+ A+AE E S + T K
Sbjct: 850 TEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAK 890
Score = 52.8 bits (125), Expect = 2e-07
Identities = 61/223 (27%), Positives = 93/223 (41%), Gaps = 31/223 (13%)
Query: 20 KEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKP------DQDAEGKAEEKEGEK 73
+EK+++ A EEG +E +P AA E A E+P ++ EG A+ K+ E
Sbjct: 808 EEKEEETAAAPPVEEG--EEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEA 865
Query: 74 DAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAP-------GPAAGGEAPK-AAEA 125
A A E A KAE ++ A+ AP+ ++ A GG+ + +
Sbjct: 866 -AEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPR 924
Query: 126 AAAPAESAAPAAGEEPSKE-EGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSK 184
+ + P A P K + + K A A P Q TK P D+ P ++ AP +
Sbjct: 925 PSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAP--TKPAPPAP 982
Query: 185 ETPA-------ATEAPSSTPKAQ----GPAASAEEPKPVEAPA 216
P A + P S+P+ + P A E KPV PA
Sbjct: 983 PPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPA 1025
Score = 36.2 bits (82), Expect = 0.024
Identities = 28/141 (19%), Positives = 62/141 (43%), Gaps = 10/141 (7%)
Query: 5 LSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEG 64
L+KK + Y + + + G + +++ ++ + Q +P +EK +++ E
Sbjct: 472 LTKKNENY----KSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEK 527
Query: 65 KAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKA-- 122
+AE++E + + KE+ K + + T G + E + ++ A G ++
Sbjct: 528 EAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMA 587
Query: 123 ----AEAAAAPAESAAPAAGE 139
+E A P +SA A+ E
Sbjct: 588 NEANSEEAITPQQSAELASME 608
Score = 28.5 bits (62), Expect = 4.9
Identities = 28/104 (26%), Positives = 36/104 (34%), Gaps = 4/104 (3%)
Query: 33 EEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEG 92
E+ P + P A P + + P Q + A + E P P
Sbjct: 970 EDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFP---AF 1026
Query: 93 AAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAP-AESAAP 135
AAEA+ P P P P E KA+ A P A S AP
Sbjct: 1027 AAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAP 1070
>gi|194248057 growth associated protein 43 isoform 1 [Homo sapiens]
Length = 274
Score = 66.2 bits (160), Expect = 2e-11
Identities = 53/184 (28%), Positives = 79/184 (42%), Gaps = 9/184 (4%)
Query: 7 KKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGK-EKPDQDAEGK 65
KK KG +D +A E + + A +G K+ E AE A A K ++P + E
Sbjct: 85 KKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETP 144
Query: 66 AEEKEGEKDAAA--AKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAA 123
+EEK+GE DAA A +AP + EK A A + A E PK A
Sbjct: 145 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQA 204
Query: 124 EAAAAPAESAA--PAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAP 181
+ AA +AA PAA + +K +P ++ A + ++ ++KP S
Sbjct: 205 DVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEA----VDETKPKESARQD 260
Query: 182 SSKE 185
KE
Sbjct: 261 EGKE 264
Score = 60.8 bits (146), Expect = 9e-10
Identities = 62/189 (32%), Positives = 82/189 (43%), Gaps = 33/189 (17%)
Query: 55 KEKPDQDAEGKAEEKEGEKDAAAAKEEAP--------KAEPEKTEGAAEAKAEPPKAPEQ 106
K DQ E + E + AA K +A K + EK + A+AE K E
Sbjct: 49 KNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEA 108
Query: 107 EQAAPGPAAGGEAPKAAEAAAAPAESAAP----AAGEEPSKE---EGEPKKTE-APAAPA 158
A G GE AEAA PA + P AGE PS+E EG+ + AP APA
Sbjct: 109 P-VADGVEKKGEGTTTAEAA--PATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPA 165
Query: 159 AQETKSDGAPASDSKPGSSEAAPSSK-------------ETPAA-TEAPSSTPKAQGPAA 204
+ E K+ A + S++ +PSSK + PAA T A ++TP A+ AA
Sbjct: 166 SSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAA 225
Query: 205 SAEEPKPVE 213
A P E
Sbjct: 226 KATAQPPTE 234
>gi|4503911 growth associated protein 43 isoform 2 [Homo sapiens]
Length = 238
Score = 66.2 bits (160), Expect = 2e-11
Identities = 53/184 (28%), Positives = 79/184 (42%), Gaps = 9/184 (4%)
Query: 7 KKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGK-EKPDQDAEGK 65
KK KG +D +A E + + A +G K+ E AE A A K ++P + E
Sbjct: 49 KKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETP 108
Query: 66 AEEKEGEKDAAA--AKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAA 123
+EEK+GE DAA A +AP + EK A A + A E PK A
Sbjct: 109 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQA 168
Query: 124 EAAAAPAESAA--PAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAP 181
+ AA +AA PAA + +K +P ++ A + ++ ++KP S
Sbjct: 169 DVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEA----VDETKPKESARQD 224
Query: 182 SSKE 185
KE
Sbjct: 225 EGKE 228
Score = 60.8 bits (146), Expect = 9e-10
Identities = 62/189 (32%), Positives = 82/189 (43%), Gaps = 33/189 (17%)
Query: 55 KEKPDQDAEGKAEEKEGEKDAAAAKEEAP--------KAEPEKTEGAAEAKAEPPKAPEQ 106
K DQ E + E + AA K +A K + EK + A+AE K E
Sbjct: 13 KNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEA 72
Query: 107 EQAAPGPAAGGEAPKAAEAAAAPAESAAP----AAGEEPSKE---EGEPKKTE-APAAPA 158
A G GE AEAA PA + P AGE PS+E EG+ + AP APA
Sbjct: 73 P-VADGVEKKGEGTTTAEAA--PATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPA 129
Query: 159 AQETKSDGAPASDSKPGSSEAAPSSK-------------ETPAA-TEAPSSTPKAQGPAA 204
+ E K+ A + S++ +PSSK + PAA T A ++TP A+ AA
Sbjct: 130 SSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAA 189
Query: 205 SAEEPKPVE 213
A P E
Sbjct: 190 KATAQPPTE 198
>gi|210032580 SET domain containing 1B [Homo sapiens]
Length = 1923
Score = 65.5 bits (158), Expect = 4e-11
Identities = 58/226 (25%), Positives = 92/226 (40%), Gaps = 21/226 (9%)
Query: 10 KGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEK 69
KG V A+ + + G E+E +E E E AE +E +E D D +E
Sbjct: 1015 KGVGVRRRPARPLELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDES 1074
Query: 70 EGEKDAAAAKEEAPK----AEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEA 125
E + + A E + K ++ E+T +KAE + E +++ ++ +P ++E
Sbjct: 1075 ENDDEDTALSEASEKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSE- 1133
Query: 126 AAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSD--------GAPASDSKPGSS 177
E A EE +EE E E+ A+ ++ + D GAPA DS G
Sbjct: 1134 ----DEEEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDSL-GME 1188
Query: 178 EAAPSSKETPAATEAPS---STPKAQGPAASAEEPKPVEAPAANSD 220
E E A E PS P G A+ +P E P + +
Sbjct: 1189 EEVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQE 1234
Score = 50.1 bits (118), Expect = 2e-06
Identities = 57/223 (25%), Positives = 79/223 (35%), Gaps = 25/223 (11%)
Query: 15 NDEKAKEKDKKAEGAATEEEGTPK-----ESEPQAAAEPAEAKEGKEKPDQDAEGKA--- 66
+ E + + EEE + E E + AE + A G E +QD E A
Sbjct: 1118 SSEFESSSESSPSSSEDEEEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAP 1177
Query: 67 ----------EEKEGEKDAAAAKEEAPKA--EPEKTEGAAEA--KAEPPKAPEQEQAAPG 112
EE+ + A A EE P EP G E EPP+ P Q G
Sbjct: 1178 GAPAVDSLGMEEEVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQ--EG 1235
Query: 113 PAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDS 172
P A E A P S A + E P P P + P+
Sbjct: 1236 AMLLSPEPPAKEVEARPPLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPPP 1295
Query: 173 KPGSSEAA-PSSKETPAATEAPSSTPKAQGPAASAEEPKPVEA 214
+P +++A+ PS P A + P TP G A ++ + V A
Sbjct: 1296 EPETTDASHPSVPPEPLAEDHPPHTPGLCGSLAKSQSTETVPA 1338
Score = 49.7 bits (117), Expect = 2e-06
Identities = 53/221 (23%), Positives = 85/221 (38%), Gaps = 24/221 (10%)
Query: 6 SKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGK 65
S+K +G + +E KAE ++ E E E + + P+ +++ +++ +
Sbjct: 1087 SEKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSED-----EEEVVAR 1141
Query: 66 AEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEA 125
EE+E E++ A+E A PE E E A P AP + + G E E
Sbjct: 1142 EEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVD------SLGMEEEVDIET 1195
Query: 126 AAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGA-------PASDSK---PG 175
A E P+ +EP G + ++ P +GA PA + + P
Sbjct: 1196 EAVAPEER-PSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPPL 1254
Query: 176 SSEAAPSSKETPAATEAPSSTP-KAQGPAASAEEPKPVEAP 215
S E AP + E P P Q P P+P P
Sbjct: 1255 SPERAP-EHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPP 1294
Score = 39.7 bits (91), Expect = 0.002
Identities = 49/243 (20%), Positives = 83/243 (34%), Gaps = 35/243 (14%)
Query: 5 LSKKKKGYNVNDEKAKEKDK----------KAEGAATEEEGTP--------------KES 40
L+ K G + ++++ K KD+ K EG E G K
Sbjct: 908 LTPVKSGEHKDEDRPKPKDRIASCLLESWGKGEGLGYEGLGLGIGLRGAIRLPSFKVKRK 967
Query: 41 EPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEP 100
EP + K + D E + E+E ++D A E K +P K G A P
Sbjct: 968 EPPDTTSSGDQKRLRPSTSVDEEDEESERERDRDMADTPCELAKRDP-KGVGVRRRPARP 1026
Query: 101 PKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQ 160
+ + + E E A E ++ S + E + + A +
Sbjct: 1027 LELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDEDTALSEA 1086
Query: 161 ETKSDG----------APASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPK 210
K +G + SSE++ SS+ ++ +PSS+ + A EE +
Sbjct: 1087 SEKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVAREEEEE 1146
Query: 211 PVE 213
E
Sbjct: 1147 EEE 1149
Score = 30.4 bits (67), Expect = 1.3
Identities = 27/96 (28%), Positives = 34/96 (35%), Gaps = 11/96 (11%)
Query: 100 PPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAA 159
PP AA G GE +A A P A P A E+P G P P
Sbjct: 409 PPPEEPTATAAFGARDSGEFRRAP--APPPLPPAEPLAKEKPGTPPG-------PPPPDT 459
Query: 160 QETKSDGAPAS--DSKPGSSEAAPSSKETPAATEAP 193
+ G P +P S P+ + +PA E P
Sbjct: 460 NSMELGGRPTFGWSPEPCDSPGTPTLESSPAGPEKP 495
Score = 30.0 bits (66), Expect = 1.7
Identities = 39/189 (20%), Positives = 61/189 (32%), Gaps = 42/189 (22%)
Query: 20 KEKDKKAEGAATEEEGTPKESEPQAAA--EPAEAKEGKEKPDQDAEG------KAEEKEG 71
+E D + E A EE + + P EPA+++E E+P EG + KE
Sbjct: 1189 EEVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKEV 1248
Query: 72 EKDAAAAKEEAPK---------------------------------AEPEKTEGAAEAKA 98
E + E AP+ EPE T+ + +
Sbjct: 1249 EARPPLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPPPEPETTDASHPSVP 1308
Query: 99 EPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAP-AAP 157
P A + PG ++ E A P +G P+ +P + P
Sbjct: 1309 PEPLAEDHPPHTPGLCGSLAKSQSTETVPATPGGEPPLSGGSSGLSLSSPQVPGSPFSYP 1368
Query: 158 AAQETKSDG 166
A + S G
Sbjct: 1369 APSPSLSSG 1377
>gi|163965366 nascent polypeptide-associated complex alpha subunit
isoform a [Homo sapiens]
Length = 2078
Score = 65.5 bits (158), Expect = 4e-11
Identities = 63/199 (31%), Positives = 82/199 (41%), Gaps = 26/199 (13%)
Query: 36 TPKESEPQAAAEPAEAK----EGKEKPDQDAEGKAEEKEGEKDAAAAKEEAP-----KAE 86
+PK + +A P K KE P KEG A A ++AP +
Sbjct: 860 SPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGP--ATPAPKQAPALSMTSSS 917
Query: 87 PEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEG 146
P+K A A P +P + A PAA +PK A +P + P A PS + G
Sbjct: 918 PKKAR-ATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGG 976
Query: 147 E--PKKTEAPAAPAAQETKSDGAPASDSKPGS----SEAAPSSKETPAATEAP--SSTPK 198
P AP PAA G PA+ S G+ + PS K +PAAT P +STP
Sbjct: 977 PATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPP 1036
Query: 199 AQGPAASAEEPKPVEAPAA 217
A P P P +PAA
Sbjct: 1037 AATP------PSPKGSPAA 1049
Score = 61.6 bits (148), Expect = 5e-10
Identities = 64/224 (28%), Positives = 86/224 (38%), Gaps = 25/224 (11%)
Query: 14 VNDEKAKEKDKKAEGAATEEEG--TPKESEP---QAAAEPAEAKEGKEKPDQ--DAEGKA 66
++ +KA EGAAT +G TP P + A + K G P D A
Sbjct: 1410 LSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPA 1469
Query: 67 EEKEGEKDAAAAKEEAPKAEPEKTE------GAAEAKAEPPKAPEQEQAAPGPAAGGEAP 120
K+ A K+ A + P+K GA A P +P++ A P AP
Sbjct: 1470 VTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAP 1529
Query: 121 ------KAAEAAAAPAESAAPAAGEEPS--KEEGEPKKTEAPAAPAAQETKSDGAPASDS 172
K A AP E+ P A PS K P EAPA P+++E S A
Sbjct: 1530 TATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVT--- 1586
Query: 173 KPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPA 216
P + + APS KE S +PK + P P + PA
Sbjct: 1587 -PSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPA 1629
Score = 61.2 bits (147), Expect = 7e-10
Identities = 59/191 (30%), Positives = 75/191 (39%), Gaps = 21/191 (10%)
Query: 37 PKESEPQAAAEPAEAKEGKEKP-DQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKT--EGA 93
PKE+ + KEG P + A + K A A APK P +GA
Sbjct: 882 PKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATP--APKGIPASPSPKGA 939
Query: 94 AEAKAEPPKAPEQEQAAPG-------PAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEG 146
A P +P+ A P PAA +PK A +P + P A PS + G
Sbjct: 940 PTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGG 999
Query: 147 --EPKKTEAPAAPAAQETKSDGAPASDSKP-GSS----EAAPSSKETPAATEAPSSTPKA 199
P AP PA G+PA+ P G+S PS K +PAAT P P
Sbjct: 1000 PATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTT 1059
Query: 200 QGPAASAEEPK 210
PAA+ PK
Sbjct: 1060 --PAATLPSPK 1068
Score = 55.8 bits (133), Expect = 3e-08
Identities = 54/200 (27%), Positives = 73/200 (36%), Gaps = 22/200 (11%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPK---AEPEKTEG 92
+PK + AA P K G P +G AA +PK A P
Sbjct: 1213 SPKGAPTTPAATPPSPKGGLATPSP---------KGAPTTPAATPPSPKGGPATPPPKGA 1263
Query: 93 AAEAKAEPPK-----APEQEQAAPGPAA-GGEAPKAAEAAAAPAESAAPAAGEEPSKE-- 144
A PP A + AP PA +PK A + P + P A PS +
Sbjct: 1264 PTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGS 1323
Query: 145 EGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQ-GPA 203
G P AP PA G P + SS+ P++ + P++TP + GPA
Sbjct: 1324 PGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPA 1383
Query: 204 ASAEEPKPVEA-PAANSDQT 222
+ PK A P+ D T
Sbjct: 1384 MTPPSPKRGPAIPSPKGDPT 1403
Score = 53.9 bits (128), Expect = 1e-07
Identities = 47/182 (25%), Positives = 62/182 (34%), Gaps = 9/182 (4%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE 95
+PK + AA P K G P +PK P
Sbjct: 935 SPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPP 994
Query: 96 AKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTE--- 152
+ P P + A PA +PK + AA + A+ P +G P T
Sbjct: 995 SPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPK 1054
Query: 153 -APAAPAAQETKSDGAPASDSKPGS---SEAAPSSKETPAATEAPSSTPKAQGPAASAEE 208
AP PAA G PA+ S G+ A P S + AT +P P PAA+
Sbjct: 1055 GAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAP--MPPAATPPS 1112
Query: 209 PK 210
PK
Sbjct: 1113 PK 1114
Score = 49.7 bits (117), Expect = 2e-06
Identities = 56/215 (26%), Positives = 79/215 (36%), Gaps = 29/215 (13%)
Query: 27 EGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAE 86
EG AT PK++ P + + K+ + P + +G AA +PK
Sbjct: 898 EGPATP---APKQA-PALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGG 953
Query: 87 PE--KTEGAAEAKAEPPKAPEQEQAAPGP-------AAGGEAPKAAEAAAAPAESAAPAA 137
P + A A P +P+ A P P AA +PK A +P + P A
Sbjct: 954 PATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPA 1013
Query: 138 GEEPSKEEGEPKKTEAPAA----PAAQETKSDGAPASDSKPGSSEAAP-----SSKETPA 188
PS + G P T P PAA G+PA+ P + P S K PA
Sbjct: 1014 VTPPSPK-GSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPA 1072
Query: 189 ------ATEAPSSTPKAQGPAASAEEPKPVEAPAA 217
A P++TP + + PK P A
Sbjct: 1073 TPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPA 1107
Score = 49.3 bits (116), Expect = 3e-06
Identities = 57/193 (29%), Positives = 73/193 (37%), Gaps = 31/193 (16%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPE--KTEGA 93
+PK + AA P K G P +G AA +PK P +GA
Sbjct: 958 SPKWAPTPPAATPPSPKGGPATPSP---------KGAPTPPAATPPSPKGGPATPSPKGA 1008
Query: 94 AEAKAEPPKAPEQEQAAPG--------PAAGGEAPKAAEAAAAPAESAAPA--AGEEPSK 143
A P +P+ AA PAA +PK + AA P AP A PS
Sbjct: 1009 PTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGS-PAATPLPKGAPTTPAATLPSP 1067
Query: 144 EEG--EPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQG 201
+ G P AP PAA G PA+ S G A TP + + +TP +G
Sbjct: 1068 KGGPATPSLKGAPTPPAATPPSPKGGPATPSPKG---APMPPAATPPSPKGGLATPPHKG 1124
Query: 202 ----PAASAEEPK 210
PAA+ PK
Sbjct: 1125 APTTPAATPPSPK 1137
Score = 49.3 bits (116), Expect = 3e-06
Identities = 56/203 (27%), Positives = 69/203 (33%), Gaps = 21/203 (10%)
Query: 27 EGAATEEEGTPKESEPQAAAEP----AEAKEGKEKPDQDAEGKAEE-KEGEKDAAAAKEE 81
+GA T TP + AA P A P A +G AA
Sbjct: 1006 KGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLP 1065
Query: 82 APKAEPE--KTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAA-----AAPAESAA 134
+PK P +GA A P +P+ A P P P A + A P A
Sbjct: 1066 SPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGA 1125
Query: 135 PA--AGEEPSKEEG--EPKKTEAPAAPAAQETKSDG---APASDSKPGSSEAAPSSKETP 187
P A PS + G P AP PAA G P P + A P S +
Sbjct: 1126 PTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGG 1185
Query: 188 AATEAPSSTPKAQGPAASAEEPK 210
AT +P P PAA+ PK
Sbjct: 1186 LATPSPKGAPTT--PAATPPSPK 1206
Score = 47.8 bits (112), Expect = 8e-06
Identities = 51/197 (25%), Positives = 71/197 (36%), Gaps = 27/197 (13%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKA--EPEKTEGA 93
+PK + AA P K G P +G AA +PK +GA
Sbjct: 1190 SPKGAPTTPAATPPSPKGGLATPSP---------KGAPTTPAATPPSPKGGLATPSPKGA 1240
Query: 94 AEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAA-----AAPAESAAP-AAGEEPSKEEGE 147
A P +P+ A P P P A + A P AP A P +G
Sbjct: 1241 PTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGG 1300
Query: 148 PKKTE---APAAPAAQETKSDGAPASDSKPGS----SEAAPSSKETPAATEAPSSTPKAQ 200
P + AP PAA G+P + G+ + PS K TP P++TP ++
Sbjct: 1301 PATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPT---LPATTPSSK 1357
Query: 201 GPAASAEEPKPVEAPAA 217
G + + PAA
Sbjct: 1358 GGPTTPSSKEGPTPPAA 1374
Score = 47.4 bits (111), Expect = 1e-05
Identities = 53/206 (25%), Positives = 72/206 (34%), Gaps = 32/206 (15%)
Query: 37 PKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKA--EPEKTEGAA 94
PK + AA P K G P +G AA +PK +GA
Sbjct: 1168 PKGAPTTPAATPPSPKGGLATPSP---------KGAPTTPAATPPSPKGGLATPSPKGAP 1218
Query: 95 EAKAEPPKAPEQEQAAPGP-------AAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEG- 146
A P +P+ A P P AA +PK A P + P A PS + G
Sbjct: 1219 TTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGL 1278
Query: 147 -EPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQG---- 201
P AP G PA+ S P + P++ TP + + TP +G
Sbjct: 1279 ATPPHKGAPNPAVVTPPSPKGGPAT-SPPKGAPTPPAA--TPPSPKGSPGTPPPKGAPTP 1335
Query: 202 PAASAEEPK-----PVEAPAANSDQT 222
PA + PK P P++ T
Sbjct: 1336 PAVTPPSPKGTPTLPATTPSSKGGPT 1361
Score = 47.0 bits (110), Expect = 1e-05
Identities = 40/164 (24%), Positives = 53/164 (32%), Gaps = 12/164 (7%)
Query: 37 PKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKT--EGAA 94
PK + AA P K G P +G + A +PK P + +GA
Sbjct: 1260 PKGAPTPPAATPPSLKGGLATPPH---------KGAPNPAVVTPPSPKGGPATSPPKGAP 1310
Query: 95 EAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAP 154
A P +P+ P P G P A + PA P E P
Sbjct: 1311 TPPAATPPSPKGSPGTP-PPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGP 1369
Query: 155 AAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPK 198
PAA + G + P A PS K P + +PK
Sbjct: 1370 TPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPK 1413
Score = 46.6 bits (109), Expect = 2e-05
Identities = 41/147 (27%), Positives = 57/147 (38%), Gaps = 16/147 (10%)
Query: 87 PEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEG 146
P+KT K E P P ++A+ PA P + A +P E P A PS +E
Sbjct: 1558 PKKTPAIPTPK-EAPATPSSKEASSPPAV---TPSTYKGAPSPKELLIPPAVTSPSPKEA 1613
Query: 147 ---------EPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTP 197
P+K A AP T P+S +S A+ + K +A P
Sbjct: 1614 PTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLP 1673
Query: 198 KAQGPAASAEEPKPVEAPAANSDQTVT 224
+GP A E + APA S +T
Sbjct: 1674 AKKGPTALKE---VLVAPAPESTPIIT 1697
Score = 45.8 bits (107), Expect = 3e-05
Identities = 53/191 (27%), Positives = 66/191 (34%), Gaps = 35/191 (18%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKA--EPEKTEGA 93
+PK + AA P K G P +G AA +PK +GA
Sbjct: 1098 SPKGAPMPPAATPPSPKGGLATPPH---------KGAPTTPAATPPSPKGGLATPPPKGA 1148
Query: 94 AEAKAEPPKAPEQEQAAPGP-------AAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEG 146
A P +P+ A P P AA +PK A +P + A PS + G
Sbjct: 1149 PTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGG 1208
Query: 147 --EPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAA 204
P AP PAA + P A PS K P A +PK GPA
Sbjct: 1209 LATPSPKGAPTTPAA----------TPPSPKGGLATPSPKGAPTTPAATPPSPKG-GPAT 1257
Query: 205 SAEEPKPVEAP 215
P P AP
Sbjct: 1258 ----PPPKGAP 1264
Score = 45.4 bits (106), Expect = 4e-05
Identities = 51/189 (26%), Positives = 63/189 (33%), Gaps = 20/189 (10%)
Query: 34 EGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKE--EAPKAEPEKTE 91
+G+P P+ A P K +G ++KE P A P
Sbjct: 1321 KGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKG 1380
Query: 92 GAAEAKAEP---PKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEP 148
G A P P P + PA +PK A A E AA PSK + P
Sbjct: 1381 GPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAAT-----PSKGDLTP 1435
Query: 149 KKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPK-AQGPAASAE 207
PA APA+ S P A PSSK P +PK P A
Sbjct: 1436 --------PAVTPVSLKKAPAT-SAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVAT 1486
Query: 208 EPKPVEAPA 216
P +APA
Sbjct: 1487 SSSPKKAPA 1495
Score = 44.3 bits (103), Expect = 9e-05
Identities = 46/167 (27%), Positives = 60/167 (35%), Gaps = 23/167 (13%)
Query: 70 EGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPE----QEQAAPGPAAGGEAPKAAEA 125
+G KD+ A P+ GA A P +P+ + P P+ P E
Sbjct: 844 QGSKDSPATTHSPTPPSPK---GAPTPSAVTPLSPKGVTLPPKETPTPSVVN-LPFPKEG 899
Query: 126 AAAPAESAAPA---AGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPS 182
A PA APA P K P PA+P+ + + A A+ P A PS
Sbjct: 900 PATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPA-ATPPSPKGGPATPS 958
Query: 183 SKETPAATEAPSSTPKAQGPAA----------SAEEPKPVEAPAANS 219
K P A +PK GPA +A P P PA S
Sbjct: 959 PKWAPTPPAATPPSPKG-GPATPSPKGAPTPPAATPPSPKGGPATPS 1004
Score = 38.9 bits (89), Expect = 0.004
Identities = 49/182 (26%), Positives = 67/182 (36%), Gaps = 30/182 (16%)
Query: 42 PQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPP 101
PQ P K+G PD G +A+ E + + K A PP
Sbjct: 803 PQTKRPPT--KKGSAGPDTPI-GNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPP 859
Query: 102 KAPEQEQAAPGPAAGGE-APKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQ 160
+ AP P+A +PK P E+ P+ P +EG PA PA +
Sbjct: 860 SP----KGAPTPSAVTPLSPKGV--TLPPKETPTPSVVNLPFPKEG-------PATPAPK 906
Query: 161 ETKSDGAPA---SDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAA 217
+ APA + S P + A P+ K PA S +PK +A P P PA
Sbjct: 907 Q-----APALSMTSSSPKKARATPAPKGIPA-----SPSPKGAPTPPAATPPSPKGGPAT 956
Query: 218 NS 219
S
Sbjct: 957 PS 958
Score = 38.1 bits (87), Expect = 0.006
Identities = 45/207 (21%), Positives = 73/207 (35%), Gaps = 15/207 (7%)
Query: 24 KKAEGAATEEEGTPKESEPQAAAEPA---EAKEGKEKPDQDAEGKAEEKEGEKDAAAAKE 80
KK T +E S +A++ PA +G P + A K+A
Sbjct: 1559 KKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPA 1618
Query: 81 EAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEE 140
P + PEK K P P P++ ++P + + + P A +
Sbjct: 1619 VTPPS-PEKGPATPAPKGTPTSPPVT------PSSLKDSPTSPASVTCKMGATVPQASKG 1671
Query: 141 PSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQ 200
++G E APA + T AP + SS +P PS+ ++
Sbjct: 1672 LPAKKGPTALKEVLVAPAPESTPIITAPTRK----GPQTKKSSATSPPICPDPSAKNGSK 1727
Query: 201 GPAASAEEPKPVEAPAANSDQTVTVKE 227
GP S P P+ +S +T K+
Sbjct: 1728 GP-LSTVAPAPLLPVQKDSSKTAKGKD 1753
Score = 35.0 bits (79), Expect = 0.053
Identities = 27/121 (22%), Positives = 46/121 (38%), Gaps = 6/121 (4%)
Query: 90 TEGAAEAKAEPPKAPEQEQAAPGPAAG-GEAPKAAEAAAAPAESAAPAAGEEPSKEEGEP 148
T A + P + P ++ A A+ G A++ + S +P P+K
Sbjct: 757 TSALAPVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTK----- 811
Query: 149 KKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEE 208
K + P P + + P +S + SK++PA T +P+ P SA
Sbjct: 812 KGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVT 871
Query: 209 P 209
P
Sbjct: 872 P 872
Score = 33.9 bits (76), Expect = 0.12
Identities = 40/197 (20%), Positives = 67/197 (34%), Gaps = 24/197 (12%)
Query: 39 ESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKA 98
+S P + PA G +K D + A E++ + ++G A
Sbjct: 732 KSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLA 791
Query: 99 EPP-----------KAPEQEQAAPGP---AAGGEAPKAAEAAAAPAESAAPAAGEEPSKE 144
+ P K P ++ + GP +P + A+ E++ G + S
Sbjct: 792 DSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDS-- 849
Query: 145 EGEPKKTEAPAAPAAQETKSDGA-----PASDSKPGSSEAAPSSKETPAATEAPSSTPKA 199
P T +P P+ + + A P + P PS P E P++
Sbjct: 850 ---PATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPK 906
Query: 200 QGPAASAEEPKPVEAPA 216
Q PA S P +A A
Sbjct: 907 QAPALSMTSSSPKKARA 923
>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
Length = 1270
Score = 63.2 bits (152), Expect = 2e-10
Identities = 56/220 (25%), Positives = 79/220 (35%), Gaps = 13/220 (5%)
Query: 10 KGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEK 69
K N D E + T + T E++ + +GKEK E ++ EK
Sbjct: 122 KPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEK 181
Query: 70 EGEKDAAAAK----EEAPKAEPEKTEGAAEAKAEPPKAPEQEQAA-----PGPAAGGEAP 120
KD A + PKAE A EP +E A+ P P AP
Sbjct: 182 TSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAP 241
Query: 121 KAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGS-SEA 179
+ A +AP +EP+ + P PA TK + S P + E
Sbjct: 242 TTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEP 301
Query: 180 APSSKETPAAT---EAPSSTPKAQGPAASAEEPKPVEAPA 216
AP++ + PA T E +TPK P E + PA
Sbjct: 302 APTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPA 341
Score = 55.8 bits (133), Expect = 3e-08
Identities = 54/203 (26%), Positives = 68/203 (33%), Gaps = 23/203 (11%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE 95
TPKE P EPA + P KE + PK EP T
Sbjct: 212 TPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPK-EPAPTTTKEP 270
Query: 96 AKAEPPKAPEQEQAAPGPAAGGEAPKAA-EAAAAPAESAAPAAGEEPSKEEGEPKKTEAP 154
A P + P P AP E A + AP +EP+ + P
Sbjct: 271 APTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTP 330
Query: 155 AAPA------AQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEE 208
PA A T + AP + KP AP++ + PA T TPK P + +E
Sbjct: 331 KEPAPTTKEPAPTTPKEPAPTAPKKP-----APTTPKEPAPT-----TPKEPAP-TTTKE 379
Query: 209 PKPV----EAPAANSDQTVTVKE 227
P P AP T KE
Sbjct: 380 PSPTTPKEPAPTTTKSAPTTTKE 402
Score = 55.1 bits (131), Expect = 5e-08
Identities = 57/199 (28%), Positives = 75/199 (37%), Gaps = 26/199 (13%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAP----KAEPEKTE 91
TPK+ P EPA KE + A E KE AP K P E
Sbjct: 438 TPKKPAPTTPKEPAPTTP-KEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPE 496
Query: 92 GAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS----KEEG- 146
A E P E+ AP E A ++AAP +EP+ KE
Sbjct: 497 KLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAP 556
Query: 147 ---------EPKKTEAPAAP--AAQETKSDGAPASDSKPGSSEAAPSSKETPAAT---EA 192
PK+T AP P A T + AP + KP E AP++ + P +T +
Sbjct: 557 TTPKEPAPTTPKET-APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKP 615
Query: 193 PSSTPKAQGPAASAEEPKP 211
+TPK P + +EP P
Sbjct: 616 APTTPKGTAP-TTPKEPAP 633
Score = 54.7 bits (130), Expect = 6e-08
Identities = 55/205 (26%), Positives = 69/205 (33%), Gaps = 13/205 (6%)
Query: 17 EKAKEKDKKAEGAATEEEG--TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKD 74
E A KK +E TPKE P EP+ + P KE
Sbjct: 347 EPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPT 406
Query: 75 AAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAA 134
+ PK EP T A P + P P E AP +
Sbjct: 407 TTKSAPTTPK-EPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 465
Query: 135 PAAGEEPSKEEGEPKKTEAPAAPA--AQETKSDGAPASDSKPGSS---EAAPSSKETPAA 189
PA PK+T AP P T AP + KP + E AP++ E P
Sbjct: 466 PAPTTPKEPAPTTPKET-APTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTP 524
Query: 190 T---EAPSSTPKAQGPAASAEEPKP 211
T E +TPKA P + +EP P
Sbjct: 525 TTPEEPAPTTPKAAAP-NTPKEPAP 548
Score = 54.3 bits (129), Expect = 8e-08
Identities = 49/203 (24%), Positives = 73/203 (35%), Gaps = 17/203 (8%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKA-------EPE 88
TPKE P EPA KE +G A E K+ APK EP
Sbjct: 550 TPKEPAPTTPKEPAPTTP-KETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPT 608
Query: 89 KTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPA--ESAAPAAGEEPSKEEG 146
T A P P P E AP + AP ++P+ +E
Sbjct: 609 STTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKEL 668
Query: 147 EPKKTEAPAAPAAQE----TKSDGAPASDSKPGSS---EAAPSSKETPAATEAPSSTPKA 199
P T+ P + + + T + AP + +P + + AP++ ETP T + STP
Sbjct: 669 APTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTT 728
Query: 200 QGPAASAEEPKPVEAPAANSDQT 222
+ + P +++ T
Sbjct: 729 TKEPTTIHKSPDESTPELSAEPT 751
Score = 53.9 bits (128), Expect = 1e-07
Identities = 49/181 (27%), Positives = 71/181 (39%), Gaps = 15/181 (8%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE 95
TPKE P EPA + P KE + PK EP T
Sbjct: 258 TPKEPAPTTTKEPAPTTPKEPAP-------TTTKEPAPTTTKSAPTTPK-EPAPTTPKKP 309
Query: 96 AKAEPPKAPEQEQAAPGPAAGGE-APKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAP 154
A P + P P E AP E A + AP A ++P+ + P
Sbjct: 310 APTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTP 369
Query: 155 AAPAAQETKSDGAPASDSKPG--SSEAAPSSKETPAATEAPSS--TPKAQGPAASAEEPK 210
PA TK + +P + +P ++++AP++ + PA T S+ TPK P + +EP
Sbjct: 370 KEPAPTTTK-EPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTT-KEPA 427
Query: 211 P 211
P
Sbjct: 428 P 428
Score = 52.8 bits (125), Expect = 2e-07
Identities = 56/220 (25%), Positives = 75/220 (34%), Gaps = 32/220 (14%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKT---EG 92
TPKE P EP + P KE A EP T E
Sbjct: 313 TPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEP 372
Query: 93 AAEAKAEP-PKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKT 151
A EP P P++ P P AP + A +AP +EPS +
Sbjct: 373 APTTTKEPSPTTPKE----PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP 428
Query: 152 EAPAAPA-------AQETKSDGAPASDSKPG---SSEAAPSSKETPAAT---EAPSSTPK 198
P PA A T + AP + +P + + AP++ + PA T E +TPK
Sbjct: 429 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPK 488
Query: 199 AQGPA-------ASAEEPKPVE----APAANSDQTVTVKE 227
P + E+P P AP + T T E
Sbjct: 489 KLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE 528
Score = 52.8 bits (125), Expect = 2e-07
Identities = 50/194 (25%), Positives = 72/194 (37%), Gaps = 27/194 (13%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE 95
TPKE P EPA + P E +G KE AP
Sbjct: 542 TPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTA-PTTLKEPAPTT---------- 590
Query: 96 AKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPA 155
PK P ++ AP + + A + AP +EP+ K AP
Sbjct: 591 -----PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAP---TTPKEPAPT 642
Query: 156 AP--AAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPS---STPKAQGPAASAEEPK 210
P A T + AP + KP E AP++ + P +T + +TPK P + +EP
Sbjct: 643 TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAP-TTPKEPA 701
Query: 211 PV--EAPAANSDQT 222
P + PA + +T
Sbjct: 702 PTTPKKPAPTTPET 715
Score = 51.6 bits (122), Expect = 5e-07
Identities = 67/250 (26%), Positives = 86/250 (34%), Gaps = 48/250 (19%)
Query: 17 EKAKEKDKKAEGAATEEEG--TPKESEPQAAAEPAEAKEGKEKPDQDAEG------KAEE 68
E A KK +E TPKE P +PA + P E K
Sbjct: 433 EPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTP 492
Query: 69 KEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEP-PKAPEQEQAAPGPAAGGEAPKAAEAAA 127
EK A E+ PE E A EP P PE+ AA PK E A
Sbjct: 493 TTPEKLAPTTPEKPAPTTPE--ELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPK--EPAP 548
Query: 128 APAESAAPAAGEEPSKEEGEPKKTEAPAAP--AAQETKSDGAPASDSKPGSSEAAPSSKE 185
+ AP +EP+ PK+T AP P A T + AP + KP E AP++ +
Sbjct: 549 TTPKEPAPTTPKEPAPTT--PKET-APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 605
Query: 186 TPAAT---------------------------EAPSSTPKAQGPAASAEEPKPV--EAPA 216
P +T E +TPK P + +EP P + PA
Sbjct: 606 EPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAP-TTLKEPAPTTPKKPA 664
Query: 217 ANSDQTVTVK 226
T K
Sbjct: 665 PKELAPTTTK 674
Score = 50.8 bits (120), Expect = 9e-07
Identities = 55/215 (25%), Positives = 76/215 (35%), Gaps = 17/215 (7%)
Query: 8 KKKGYNVNDEKAKEKDKKAEGAATEEEG-TPKESEPQAAAEPAEAKEGKEKPDQDAEGKA 66
K+ E A K+ T+E T +S P EPA K P E A
Sbjct: 260 KEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKE-PA 318
Query: 67 EEKEGEKDAAAAKEEAPKA-EPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEA 125
E KE AP EP T A P K P P E
Sbjct: 319 PTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTK 378
Query: 126 AAAPAESAAPAAGEEPSKEEGEPKKTEAPA---APAAQETKSDGAPASDSKPGSS---EA 179
+P PA P+ + P T+ PA +A T + +P + +P + E
Sbjct: 379 EPSPTTPKEPA----PTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEP 434
Query: 180 APSSKETPAAT---EAPSSTPKAQGPAASAEEPKP 211
AP++ + PA T E +TPK P + ++P P
Sbjct: 435 APTTPKKPAPTTPKEPAPTTPKEPAP-TTTKKPAP 468
Score = 42.7 bits (99), Expect = 3e-04
Identities = 48/206 (23%), Positives = 74/206 (35%), Gaps = 21/206 (10%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKA-EPEKTEGAA 94
TPK + P EPA KE +G A E K+ APK P T+G
Sbjct: 619 TPKGTAPTTPKEPAPTTP-KEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPT 677
Query: 95 EAKAEPPKAPEQEQAAPG----PAAGGEAPKAAEAAAAP----AESAAPAAGEEP----- 141
++ P ++ AP PA A P +E + P +EP
Sbjct: 678 STTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHK 737
Query: 142 SKEEGEPKKTEAPAAPAAQET-KSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQ 200
S +E P+ + P A + + K G P + + AA + T A + +
Sbjct: 738 SPDESTPELSAEPTPKALENSPKEPGVPTT-----KTPAATKPEMTTTAKDKTTERDLRT 792
Query: 201 GPAASAEEPKPVEAPAANSDQTVTVK 226
P + PK + A +++T K
Sbjct: 793 TPETTTAAPKMTKETATTTEKTTESK 818
Score = 33.9 bits (76), Expect = 0.12
Identities = 42/190 (22%), Positives = 62/190 (32%), Gaps = 18/190 (9%)
Query: 34 EGTPK--ESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEE---APKAEPE 88
E TPK E+ P+ P KP+ K +K E+D E APK E
Sbjct: 749 EPTPKALENSPKEPGVPTTKTPAATKPEMTTTAK--DKTTERDLRTTPETTTAAPKMTKE 806
Query: 89 K-------TEGAAEAKAEPPKAPEQEQAAPGPAAGGE----APKAAEAAAAPAESAAPAA 137
TE A + + P + APK +
Sbjct: 807 TATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNK 866
Query: 138 GEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTP 197
EE +K + ++A + TK+ P S KP + K TP + S+ P
Sbjct: 867 PEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMP 926
Query: 198 KAQGPAASAE 207
+ + AE
Sbjct: 927 ELNPTSRIAE 936
>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
Length = 1311
Score = 63.2 bits (152), Expect = 2e-10
Identities = 56/220 (25%), Positives = 79/220 (35%), Gaps = 13/220 (5%)
Query: 10 KGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEK 69
K N D E + T + T E++ + +GKEK E ++ EK
Sbjct: 163 KPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEK 222
Query: 70 EGEKDAAAAK----EEAPKAEPEKTEGAAEAKAEPPKAPEQEQAA-----PGPAAGGEAP 120
KD A + PKAE A EP +E A+ P P AP
Sbjct: 223 TSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAP 282
Query: 121 KAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGS-SEA 179
+ A +AP +EP+ + P PA TK + S P + E
Sbjct: 283 TTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEP 342
Query: 180 APSSKETPAAT---EAPSSTPKAQGPAASAEEPKPVEAPA 216
AP++ + PA T E +TPK P E + PA
Sbjct: 343 APTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPA 382
Score = 55.8 bits (133), Expect = 3e-08
Identities = 54/203 (26%), Positives = 68/203 (33%), Gaps = 23/203 (11%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE 95
TPKE P EPA + P KE + PK EP T
Sbjct: 253 TPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPK-EPAPTTTKEP 311
Query: 96 AKAEPPKAPEQEQAAPGPAAGGEAPKAA-EAAAAPAESAAPAAGEEPSKEEGEPKKTEAP 154
A P + P P AP E A + AP +EP+ + P
Sbjct: 312 APTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTP 371
Query: 155 AAPA------AQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEE 208
PA A T + AP + KP AP++ + PA T TPK P + +E
Sbjct: 372 KEPAPTTKEPAPTTPKEPAPTAPKKP-----APTTPKEPAPT-----TPKEPAP-TTTKE 420
Query: 209 PKPV----EAPAANSDQTVTVKE 227
P P AP T KE
Sbjct: 421 PSPTTPKEPAPTTTKSAPTTTKE 443
Score = 55.1 bits (131), Expect = 5e-08
Identities = 57/199 (28%), Positives = 75/199 (37%), Gaps = 26/199 (13%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAP----KAEPEKTE 91
TPK+ P EPA KE + A E KE AP K P E
Sbjct: 479 TPKKPAPTTPKEPAPTTP-KEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPE 537
Query: 92 GAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS----KEEG- 146
A E P E+ AP E A ++AAP +EP+ KE
Sbjct: 538 KLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAP 597
Query: 147 ---------EPKKTEAPAAP--AAQETKSDGAPASDSKPGSSEAAPSSKETPAAT---EA 192
PK+T AP P A T + AP + KP E AP++ + P +T +
Sbjct: 598 TTPKEPAPTTPKET-APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKP 656
Query: 193 PSSTPKAQGPAASAEEPKP 211
+TPK P + +EP P
Sbjct: 657 APTTPKGTAP-TTPKEPAP 674
Score = 54.7 bits (130), Expect = 6e-08
Identities = 55/205 (26%), Positives = 69/205 (33%), Gaps = 13/205 (6%)
Query: 17 EKAKEKDKKAEGAATEEEG--TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKD 74
E A KK +E TPKE P EP+ + P KE
Sbjct: 388 EPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPT 447
Query: 75 AAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAA 134
+ PK EP T A P + P P E AP +
Sbjct: 448 TTKSAPTTPK-EPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 506
Query: 135 PAAGEEPSKEEGEPKKTEAPAAPA--AQETKSDGAPASDSKPGSS---EAAPSSKETPAA 189
PA PK+T AP P T AP + KP + E AP++ E P
Sbjct: 507 PAPTTPKEPAPTTPKET-APTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTP 565
Query: 190 T---EAPSSTPKAQGPAASAEEPKP 211
T E +TPKA P + +EP P
Sbjct: 566 TTPEEPAPTTPKAAAP-NTPKEPAP 589
Score = 54.3 bits (129), Expect = 8e-08
Identities = 49/203 (24%), Positives = 73/203 (35%), Gaps = 17/203 (8%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKA-------EPE 88
TPKE P EPA KE +G A E K+ APK EP
Sbjct: 591 TPKEPAPTTPKEPAPTTP-KETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPT 649
Query: 89 KTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPA--ESAAPAAGEEPSKEEG 146
T A P P P E AP + AP ++P+ +E
Sbjct: 650 STTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKEL 709
Query: 147 EPKKTEAPAAPAAQE----TKSDGAPASDSKPGSS---EAAPSSKETPAATEAPSSTPKA 199
P T+ P + + + T + AP + +P + + AP++ ETP T + STP
Sbjct: 710 APTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTT 769
Query: 200 QGPAASAEEPKPVEAPAANSDQT 222
+ + P +++ T
Sbjct: 770 TKEPTTIHKSPDESTPELSAEPT 792
Score = 53.9 bits (128), Expect = 1e-07
Identities = 49/181 (27%), Positives = 71/181 (39%), Gaps = 15/181 (8%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE 95
TPKE P EPA + P KE + PK EP T
Sbjct: 299 TPKEPAPTTTKEPAPTTPKEPAP-------TTTKEPAPTTTKSAPTTPK-EPAPTTPKKP 350
Query: 96 AKAEPPKAPEQEQAAPGPAAGGE-APKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAP 154
A P + P P E AP E A + AP A ++P+ + P
Sbjct: 351 APTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTP 410
Query: 155 AAPAAQETKSDGAPASDSKPG--SSEAAPSSKETPAATEAPSS--TPKAQGPAASAEEPK 210
PA TK + +P + +P ++++AP++ + PA T S+ TPK P + +EP
Sbjct: 411 KEPAPTTTK-EPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTT-KEPA 468
Query: 211 P 211
P
Sbjct: 469 P 469
Score = 52.8 bits (125), Expect = 2e-07
Identities = 56/220 (25%), Positives = 75/220 (34%), Gaps = 32/220 (14%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKT---EG 92
TPKE P EP + P KE A EP T E
Sbjct: 354 TPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEP 413
Query: 93 AAEAKAEP-PKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKT 151
A EP P P++ P P AP + A +AP +EPS +
Sbjct: 414 APTTTKEPSPTTPKE----PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP 469
Query: 152 EAPAAPA-------AQETKSDGAPASDSKPG---SSEAAPSSKETPAAT---EAPSSTPK 198
P PA A T + AP + +P + + AP++ + PA T E +TPK
Sbjct: 470 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPK 529
Query: 199 AQGPA-------ASAEEPKPVE----APAANSDQTVTVKE 227
P + E+P P AP + T T E
Sbjct: 530 KLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE 569
Score = 52.8 bits (125), Expect = 2e-07
Identities = 50/194 (25%), Positives = 72/194 (37%), Gaps = 27/194 (13%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE 95
TPKE P EPA + P E +G KE AP
Sbjct: 583 TPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTA-PTTLKEPAPTT---------- 631
Query: 96 AKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPA 155
PK P ++ AP + + A + AP +EP+ K AP
Sbjct: 632 -----PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAP---TTPKEPAPT 683
Query: 156 AP--AAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPS---STPKAQGPAASAEEPK 210
P A T + AP + KP E AP++ + P +T + +TPK P + +EP
Sbjct: 684 TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAP-TTPKEPA 742
Query: 211 PV--EAPAANSDQT 222
P + PA + +T
Sbjct: 743 PTTPKKPAPTTPET 756
Score = 51.6 bits (122), Expect = 5e-07
Identities = 67/250 (26%), Positives = 86/250 (34%), Gaps = 48/250 (19%)
Query: 17 EKAKEKDKKAEGAATEEEG--TPKESEPQAAAEPAEAKEGKEKPDQDAEG------KAEE 68
E A KK +E TPKE P +PA + P E K
Sbjct: 474 EPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTP 533
Query: 69 KEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEP-PKAPEQEQAAPGPAAGGEAPKAAEAAA 127
EK A E+ PE E A EP P PE+ AA PK E A
Sbjct: 534 TTPEKLAPTTPEKPAPTTPE--ELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPK--EPAP 589
Query: 128 APAESAAPAAGEEPSKEEGEPKKTEAPAAP--AAQETKSDGAPASDSKPGSSEAAPSSKE 185
+ AP +EP+ PK+T AP P A T + AP + KP E AP++ +
Sbjct: 590 TTPKEPAPTTPKEPAPTT--PKET-APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 646
Query: 186 TPAAT---------------------------EAPSSTPKAQGPAASAEEPKPV--EAPA 216
P +T E +TPK P + +EP P + PA
Sbjct: 647 EPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAP-TTLKEPAPTTPKKPA 705
Query: 217 ANSDQTVTVK 226
T K
Sbjct: 706 PKELAPTTTK 715
Score = 50.8 bits (120), Expect = 9e-07
Identities = 55/215 (25%), Positives = 76/215 (35%), Gaps = 17/215 (7%)
Query: 8 KKKGYNVNDEKAKEKDKKAEGAATEEEG-TPKESEPQAAAEPAEAKEGKEKPDQDAEGKA 66
K+ E A K+ T+E T +S P EPA K P E A
Sbjct: 301 KEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKE-PA 359
Query: 67 EEKEGEKDAAAAKEEAPKA-EPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEA 125
E KE AP EP T A P K P P E
Sbjct: 360 PTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTK 419
Query: 126 AAAPAESAAPAAGEEPSKEEGEPKKTEAPA---APAAQETKSDGAPASDSKPGSS---EA 179
+P PA P+ + P T+ PA +A T + +P + +P + E
Sbjct: 420 EPSPTTPKEPA----PTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEP 475
Query: 180 APSSKETPAAT---EAPSSTPKAQGPAASAEEPKP 211
AP++ + PA T E +TPK P + ++P P
Sbjct: 476 APTTPKKPAPTTPKEPAPTTPKEPAP-TTTKKPAP 509
Score = 42.7 bits (99), Expect = 3e-04
Identities = 48/206 (23%), Positives = 74/206 (35%), Gaps = 21/206 (10%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKA-EPEKTEGAA 94
TPK + P EPA KE +G A E K+ APK P T+G
Sbjct: 660 TPKGTAPTTPKEPAPTTP-KEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPT 718
Query: 95 EAKAEPPKAPEQEQAAPG----PAAGGEAPKAAEAAAAP----AESAAPAAGEEP----- 141
++ P ++ AP PA A P +E + P +EP
Sbjct: 719 STTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHK 778
Query: 142 SKEEGEPKKTEAPAAPAAQET-KSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQ 200
S +E P+ + P A + + K G P + + AA + T A + +
Sbjct: 779 SPDESTPELSAEPTPKALENSPKEPGVPTT-----KTPAATKPEMTTTAKDKTTERDLRT 833
Query: 201 GPAASAEEPKPVEAPAANSDQTVTVK 226
P + PK + A +++T K
Sbjct: 834 TPETTTAAPKMTKETATTTEKTTESK 859
Score = 33.9 bits (76), Expect = 0.12
Identities = 42/190 (22%), Positives = 62/190 (32%), Gaps = 18/190 (9%)
Query: 34 EGTPK--ESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEE---APKAEPE 88
E TPK E+ P+ P KP+ K +K E+D E APK E
Sbjct: 790 EPTPKALENSPKEPGVPTTKTPAATKPEMTTTAK--DKTTERDLRTTPETTTAAPKMTKE 847
Query: 89 K-------TEGAAEAKAEPPKAPEQEQAAPGPAAGGE----APKAAEAAAAPAESAAPAA 137
TE A + + P + APK +
Sbjct: 848 TATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNK 907
Query: 138 GEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTP 197
EE +K + ++A + TK+ P S KP + K TP + S+ P
Sbjct: 908 PEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMP 967
Query: 198 KAQGPAASAE 207
+ + AE
Sbjct: 968 ELNPTSRIAE 977
>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
Length = 1363
Score = 63.2 bits (152), Expect = 2e-10
Identities = 56/220 (25%), Positives = 79/220 (35%), Gaps = 13/220 (5%)
Query: 10 KGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEK 69
K N D E + T + T E++ + +GKEK E ++ EK
Sbjct: 215 KPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEK 274
Query: 70 EGEKDAAAAK----EEAPKAEPEKTEGAAEAKAEPPKAPEQEQAA-----PGPAAGGEAP 120
KD A + PKAE A EP +E A+ P P AP
Sbjct: 275 TSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAP 334
Query: 121 KAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGS-SEA 179
+ A +AP +EP+ + P PA TK + S P + E
Sbjct: 335 TTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEP 394
Query: 180 APSSKETPAAT---EAPSSTPKAQGPAASAEEPKPVEAPA 216
AP++ + PA T E +TPK P E + PA
Sbjct: 395 APTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPA 434
Score = 55.8 bits (133), Expect = 3e-08
Identities = 54/203 (26%), Positives = 68/203 (33%), Gaps = 23/203 (11%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE 95
TPKE P EPA + P KE + PK EP T
Sbjct: 305 TPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPK-EPAPTTTKEP 363
Query: 96 AKAEPPKAPEQEQAAPGPAAGGEAPKAA-EAAAAPAESAAPAAGEEPSKEEGEPKKTEAP 154
A P + P P AP E A + AP +EP+ + P
Sbjct: 364 APTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTP 423
Query: 155 AAPA------AQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEE 208
PA A T + AP + KP AP++ + PA T TPK P + +E
Sbjct: 424 KEPAPTTKEPAPTTPKEPAPTAPKKP-----APTTPKEPAPT-----TPKEPAP-TTTKE 472
Query: 209 PKPV----EAPAANSDQTVTVKE 227
P P AP T KE
Sbjct: 473 PSPTTPKEPAPTTTKSAPTTTKE 495
Score = 55.1 bits (131), Expect = 5e-08
Identities = 57/199 (28%), Positives = 75/199 (37%), Gaps = 26/199 (13%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAP----KAEPEKTE 91
TPK+ P EPA KE + A E KE AP K P E
Sbjct: 531 TPKKPAPTTPKEPAPTTP-KEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPE 589
Query: 92 GAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS----KEEG- 146
A E P E+ AP E A ++AAP +EP+ KE
Sbjct: 590 KLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAP 649
Query: 147 ---------EPKKTEAPAAP--AAQETKSDGAPASDSKPGSSEAAPSSKETPAAT---EA 192
PK+T AP P A T + AP + KP E AP++ + P +T +
Sbjct: 650 TTPKEPAPTTPKET-APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKP 708
Query: 193 PSSTPKAQGPAASAEEPKP 211
+TPK P + +EP P
Sbjct: 709 APTTPKGTAP-TTPKEPAP 726
Score = 54.7 bits (130), Expect = 6e-08
Identities = 55/205 (26%), Positives = 69/205 (33%), Gaps = 13/205 (6%)
Query: 17 EKAKEKDKKAEGAATEEEG--TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKD 74
E A KK +E TPKE P EP+ + P KE
Sbjct: 440 EPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPT 499
Query: 75 AAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAA 134
+ PK EP T A P + P P E AP +
Sbjct: 500 TTKSAPTTPK-EPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 558
Query: 135 PAAGEEPSKEEGEPKKTEAPAAPA--AQETKSDGAPASDSKPGSS---EAAPSSKETPAA 189
PA PK+T AP P T AP + KP + E AP++ E P
Sbjct: 559 PAPTTPKEPAPTTPKET-APTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTP 617
Query: 190 T---EAPSSTPKAQGPAASAEEPKP 211
T E +TPKA P + +EP P
Sbjct: 618 TTPEEPAPTTPKAAAP-NTPKEPAP 641
Score = 54.3 bits (129), Expect = 8e-08
Identities = 49/203 (24%), Positives = 73/203 (35%), Gaps = 17/203 (8%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKA-------EPE 88
TPKE P EPA KE +G A E K+ APK EP
Sbjct: 643 TPKEPAPTTPKEPAPTTP-KETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPT 701
Query: 89 KTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPA--ESAAPAAGEEPSKEEG 146
T A P P P E AP + AP ++P+ +E
Sbjct: 702 STTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKEL 761
Query: 147 EPKKTEAPAAPAAQE----TKSDGAPASDSKPGSS---EAAPSSKETPAATEAPSSTPKA 199
P T+ P + + + T + AP + +P + + AP++ ETP T + STP
Sbjct: 762 APTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTT 821
Query: 200 QGPAASAEEPKPVEAPAANSDQT 222
+ + P +++ T
Sbjct: 822 TKEPTTIHKSPDESTPELSAEPT 844
Score = 53.9 bits (128), Expect = 1e-07
Identities = 49/181 (27%), Positives = 71/181 (39%), Gaps = 15/181 (8%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE 95
TPKE P EPA + P KE + PK EP T
Sbjct: 351 TPKEPAPTTTKEPAPTTPKEPAP-------TTTKEPAPTTTKSAPTTPK-EPAPTTPKKP 402
Query: 96 AKAEPPKAPEQEQAAPGPAAGGE-APKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAP 154
A P + P P E AP E A + AP A ++P+ + P
Sbjct: 403 APTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTP 462
Query: 155 AAPAAQETKSDGAPASDSKPG--SSEAAPSSKETPAATEAPSS--TPKAQGPAASAEEPK 210
PA TK + +P + +P ++++AP++ + PA T S+ TPK P + +EP
Sbjct: 463 KEPAPTTTK-EPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTT-KEPA 520
Query: 211 P 211
P
Sbjct: 521 P 521
Score = 52.8 bits (125), Expect = 2e-07
Identities = 56/220 (25%), Positives = 75/220 (34%), Gaps = 32/220 (14%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKT---EG 92
TPKE P EP + P KE A EP T E
Sbjct: 406 TPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEP 465
Query: 93 AAEAKAEP-PKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKT 151
A EP P P++ P P AP + A +AP +EPS +
Sbjct: 466 APTTTKEPSPTTPKE----PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP 521
Query: 152 EAPAAPA-------AQETKSDGAPASDSKPG---SSEAAPSSKETPAAT---EAPSSTPK 198
P PA A T + AP + +P + + AP++ + PA T E +TPK
Sbjct: 522 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPK 581
Query: 199 AQGPA-------ASAEEPKPVE----APAANSDQTVTVKE 227
P + E+P P AP + T T E
Sbjct: 582 KLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE 621
Score = 52.8 bits (125), Expect = 2e-07
Identities = 50/194 (25%), Positives = 72/194 (37%), Gaps = 27/194 (13%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE 95
TPKE P EPA + P E +G KE AP
Sbjct: 635 TPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTA-PTTLKEPAPTT---------- 683
Query: 96 AKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPA 155
PK P ++ AP + + A + AP +EP+ K AP
Sbjct: 684 -----PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAP---TTPKEPAPT 735
Query: 156 AP--AAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPS---STPKAQGPAASAEEPK 210
P A T + AP + KP E AP++ + P +T + +TPK P + +EP
Sbjct: 736 TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAP-TTPKEPA 794
Query: 211 PV--EAPAANSDQT 222
P + PA + +T
Sbjct: 795 PTTPKKPAPTTPET 808
Score = 51.6 bits (122), Expect = 5e-07
Identities = 67/250 (26%), Positives = 86/250 (34%), Gaps = 48/250 (19%)
Query: 17 EKAKEKDKKAEGAATEEEG--TPKESEPQAAAEPAEAKEGKEKPDQDAEG------KAEE 68
E A KK +E TPKE P +PA + P E K
Sbjct: 526 EPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTP 585
Query: 69 KEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEP-PKAPEQEQAAPGPAAGGEAPKAAEAAA 127
EK A E+ PE E A EP P PE+ AA PK E A
Sbjct: 586 TTPEKLAPTTPEKPAPTTPE--ELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPK--EPAP 641
Query: 128 APAESAAPAAGEEPSKEEGEPKKTEAPAAP--AAQETKSDGAPASDSKPGSSEAAPSSKE 185
+ AP +EP+ PK+T AP P A T + AP + KP E AP++ +
Sbjct: 642 TTPKEPAPTTPKEPAPTT--PKET-APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 698
Query: 186 TPAAT---------------------------EAPSSTPKAQGPAASAEEPKPV--EAPA 216
P +T E +TPK P + +EP P + PA
Sbjct: 699 EPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAP-TTLKEPAPTTPKKPA 757
Query: 217 ANSDQTVTVK 226
T K
Sbjct: 758 PKELAPTTTK 767
Score = 50.8 bits (120), Expect = 9e-07
Identities = 55/215 (25%), Positives = 76/215 (35%), Gaps = 17/215 (7%)
Query: 8 KKKGYNVNDEKAKEKDKKAEGAATEEEG-TPKESEPQAAAEPAEAKEGKEKPDQDAEGKA 66
K+ E A K+ T+E T +S P EPA K P E A
Sbjct: 353 KEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKE-PA 411
Query: 67 EEKEGEKDAAAAKEEAPKA-EPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEA 125
E KE AP EP T A P K P P E
Sbjct: 412 PTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTK 471
Query: 126 AAAPAESAAPAAGEEPSKEEGEPKKTEAPA---APAAQETKSDGAPASDSKPGSS---EA 179
+P PA P+ + P T+ PA +A T + +P + +P + E
Sbjct: 472 EPSPTTPKEPA----PTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEP 527
Query: 180 APSSKETPAAT---EAPSSTPKAQGPAASAEEPKP 211
AP++ + PA T E +TPK P + ++P P
Sbjct: 528 APTTPKKPAPTTPKEPAPTTPKEPAP-TTTKKPAP 561
Score = 42.7 bits (99), Expect = 3e-04
Identities = 48/206 (23%), Positives = 74/206 (35%), Gaps = 21/206 (10%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKA-EPEKTEGAA 94
TPK + P EPA KE +G A E K+ APK P T+G
Sbjct: 712 TPKGTAPTTPKEPAPTTP-KEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPT 770
Query: 95 EAKAEPPKAPEQEQAAPG----PAAGGEAPKAAEAAAAP----AESAAPAAGEEP----- 141
++ P ++ AP PA A P +E + P +EP
Sbjct: 771 STTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHK 830
Query: 142 SKEEGEPKKTEAPAAPAAQET-KSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQ 200
S +E P+ + P A + + K G P + + AA + T A + +
Sbjct: 831 SPDESTPELSAEPTPKALENSPKEPGVPTT-----KTPAATKPEMTTTAKDKTTERDLRT 885
Query: 201 GPAASAEEPKPVEAPAANSDQTVTVK 226
P + PK + A +++T K
Sbjct: 886 TPETTTAAPKMTKETATTTEKTTESK 911
Score = 33.9 bits (76), Expect = 0.12
Identities = 42/190 (22%), Positives = 62/190 (32%), Gaps = 18/190 (9%)
Query: 34 EGTPK--ESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEE---APKAEPE 88
E TPK E+ P+ P KP+ K +K E+D E APK E
Sbjct: 842 EPTPKALENSPKEPGVPTTKTPAATKPEMTTTAK--DKTTERDLRTTPETTTAAPKMTKE 899
Query: 89 K-------TEGAAEAKAEPPKAPEQEQAAPGPAAGGE----APKAAEAAAAPAESAAPAA 137
TE A + + P + APK +
Sbjct: 900 TATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNK 959
Query: 138 GEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTP 197
EE +K + ++A + TK+ P S KP + K TP + S+ P
Sbjct: 960 PEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMP 1019
Query: 198 KAQGPAASAE 207
+ + AE
Sbjct: 1020 ELNPTSRIAE 1029
>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
Length = 1404
Score = 63.2 bits (152), Expect = 2e-10
Identities = 56/220 (25%), Positives = 79/220 (35%), Gaps = 13/220 (5%)
Query: 10 KGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEK 69
K N D E + T + T E++ + +GKEK E ++ EK
Sbjct: 256 KPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEK 315
Query: 70 EGEKDAAAAK----EEAPKAEPEKTEGAAEAKAEPPKAPEQEQAA-----PGPAAGGEAP 120
KD A + PKAE A EP +E A+ P P AP
Sbjct: 316 TSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAP 375
Query: 121 KAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGS-SEA 179
+ A +AP +EP+ + P PA TK + S P + E
Sbjct: 376 TTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEP 435
Query: 180 APSSKETPAAT---EAPSSTPKAQGPAASAEEPKPVEAPA 216
AP++ + PA T E +TPK P E + PA
Sbjct: 436 APTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPA 475
Score = 55.8 bits (133), Expect = 3e-08
Identities = 54/203 (26%), Positives = 68/203 (33%), Gaps = 23/203 (11%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE 95
TPKE P EPA + P KE + PK EP T
Sbjct: 346 TPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPK-EPAPTTTKEP 404
Query: 96 AKAEPPKAPEQEQAAPGPAAGGEAPKAA-EAAAAPAESAAPAAGEEPSKEEGEPKKTEAP 154
A P + P P AP E A + AP +EP+ + P
Sbjct: 405 APTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTP 464
Query: 155 AAPA------AQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEE 208
PA A T + AP + KP AP++ + PA T TPK P + +E
Sbjct: 465 KEPAPTTKEPAPTTPKEPAPTAPKKP-----APTTPKEPAPT-----TPKEPAP-TTTKE 513
Query: 209 PKPV----EAPAANSDQTVTVKE 227
P P AP T KE
Sbjct: 514 PSPTTPKEPAPTTTKSAPTTTKE 536
Score = 55.1 bits (131), Expect = 5e-08
Identities = 57/199 (28%), Positives = 75/199 (37%), Gaps = 26/199 (13%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAP----KAEPEKTE 91
TPK+ P EPA KE + A E KE AP K P E
Sbjct: 572 TPKKPAPTTPKEPAPTTP-KEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPE 630
Query: 92 GAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPS----KEEG- 146
A E P E+ AP E A ++AAP +EP+ KE
Sbjct: 631 KLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAP 690
Query: 147 ---------EPKKTEAPAAP--AAQETKSDGAPASDSKPGSSEAAPSSKETPAAT---EA 192
PK+T AP P A T + AP + KP E AP++ + P +T +
Sbjct: 691 TTPKEPAPTTPKET-APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKP 749
Query: 193 PSSTPKAQGPAASAEEPKP 211
+TPK P + +EP P
Sbjct: 750 APTTPKGTAP-TTPKEPAP 767
Score = 54.7 bits (130), Expect = 6e-08
Identities = 55/205 (26%), Positives = 69/205 (33%), Gaps = 13/205 (6%)
Query: 17 EKAKEKDKKAEGAATEEEG--TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKD 74
E A KK +E TPKE P EP+ + P KE
Sbjct: 481 EPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPT 540
Query: 75 AAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAA 134
+ PK EP T A P + P P E AP +
Sbjct: 541 TTKSAPTTPK-EPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 599
Query: 135 PAAGEEPSKEEGEPKKTEAPAAPA--AQETKSDGAPASDSKPGSS---EAAPSSKETPAA 189
PA PK+T AP P T AP + KP + E AP++ E P
Sbjct: 600 PAPTTPKEPAPTTPKET-APTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTP 658
Query: 190 T---EAPSSTPKAQGPAASAEEPKP 211
T E +TPKA P + +EP P
Sbjct: 659 TTPEEPAPTTPKAAAP-NTPKEPAP 682
Score = 54.3 bits (129), Expect = 8e-08
Identities = 49/203 (24%), Positives = 73/203 (35%), Gaps = 17/203 (8%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKA-------EPE 88
TPKE P EPA KE +G A E K+ APK EP
Sbjct: 684 TPKEPAPTTPKEPAPTTP-KETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPT 742
Query: 89 KTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPA--ESAAPAAGEEPSKEEG 146
T A P P P E AP + AP ++P+ +E
Sbjct: 743 STTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKEL 802
Query: 147 EPKKTEAPAAPAAQE----TKSDGAPASDSKPGSS---EAAPSSKETPAATEAPSSTPKA 199
P T+ P + + + T + AP + +P + + AP++ ETP T + STP
Sbjct: 803 APTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTT 862
Query: 200 QGPAASAEEPKPVEAPAANSDQT 222
+ + P +++ T
Sbjct: 863 TKEPTTIHKSPDESTPELSAEPT 885
Score = 53.9 bits (128), Expect = 1e-07
Identities = 49/181 (27%), Positives = 71/181 (39%), Gaps = 15/181 (8%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE 95
TPKE P EPA + P KE + PK EP T
Sbjct: 392 TPKEPAPTTTKEPAPTTPKEPAP-------TTTKEPAPTTTKSAPTTPK-EPAPTTPKKP 443
Query: 96 AKAEPPKAPEQEQAAPGPAAGGE-APKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAP 154
A P + P P E AP E A + AP A ++P+ + P
Sbjct: 444 APTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTP 503
Query: 155 AAPAAQETKSDGAPASDSKPG--SSEAAPSSKETPAATEAPSS--TPKAQGPAASAEEPK 210
PA TK + +P + +P ++++AP++ + PA T S+ TPK P + +EP
Sbjct: 504 KEPAPTTTK-EPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTT-KEPA 561
Query: 211 P 211
P
Sbjct: 562 P 562
Score = 52.8 bits (125), Expect = 2e-07
Identities = 56/220 (25%), Positives = 75/220 (34%), Gaps = 32/220 (14%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKT---EG 92
TPKE P EP + P KE A EP T E
Sbjct: 447 TPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEP 506
Query: 93 AAEAKAEP-PKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKT 151
A EP P P++ P P AP + A +AP +EPS +
Sbjct: 507 APTTTKEPSPTTPKE----PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP 562
Query: 152 EAPAAPA-------AQETKSDGAPASDSKPG---SSEAAPSSKETPAAT---EAPSSTPK 198
P PA A T + AP + +P + + AP++ + PA T E +TPK
Sbjct: 563 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPK 622
Query: 199 AQGPA-------ASAEEPKPVE----APAANSDQTVTVKE 227
P + E+P P AP + T T E
Sbjct: 623 KLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE 662
Score = 52.8 bits (125), Expect = 2e-07
Identities = 50/194 (25%), Positives = 72/194 (37%), Gaps = 27/194 (13%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE 95
TPKE P EPA + P E +G KE AP
Sbjct: 676 TPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTA-PTTLKEPAPTT---------- 724
Query: 96 AKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPA 155
PK P ++ AP + + A + AP +EP+ K AP
Sbjct: 725 -----PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAP---TTPKEPAPT 776
Query: 156 AP--AAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPS---STPKAQGPAASAEEPK 210
P A T + AP + KP E AP++ + P +T + +TPK P + +EP
Sbjct: 777 TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAP-TTPKEPA 835
Query: 211 PV--EAPAANSDQT 222
P + PA + +T
Sbjct: 836 PTTPKKPAPTTPET 849
Score = 51.6 bits (122), Expect = 5e-07
Identities = 67/250 (26%), Positives = 86/250 (34%), Gaps = 48/250 (19%)
Query: 17 EKAKEKDKKAEGAATEEEG--TPKESEPQAAAEPAEAKEGKEKPDQDAEG------KAEE 68
E A KK +E TPKE P +PA + P E K
Sbjct: 567 EPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTP 626
Query: 69 KEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEP-PKAPEQEQAAPGPAAGGEAPKAAEAAA 127
EK A E+ PE E A EP P PE+ AA PK E A
Sbjct: 627 TTPEKLAPTTPEKPAPTTPE--ELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPK--EPAP 682
Query: 128 APAESAAPAAGEEPSKEEGEPKKTEAPAAP--AAQETKSDGAPASDSKPGSSEAAPSSKE 185
+ AP +EP+ PK+T AP P A T + AP + KP E AP++ +
Sbjct: 683 TTPKEPAPTTPKEPAPTT--PKET-APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 739
Query: 186 TPAAT---------------------------EAPSSTPKAQGPAASAEEPKPV--EAPA 216
P +T E +TPK P + +EP P + PA
Sbjct: 740 EPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAP-TTLKEPAPTTPKKPA 798
Query: 217 ANSDQTVTVK 226
T K
Sbjct: 799 PKELAPTTTK 808
Score = 50.8 bits (120), Expect = 9e-07
Identities = 55/215 (25%), Positives = 76/215 (35%), Gaps = 17/215 (7%)
Query: 8 KKKGYNVNDEKAKEKDKKAEGAATEEEG-TPKESEPQAAAEPAEAKEGKEKPDQDAEGKA 66
K+ E A K+ T+E T +S P EPA K P E A
Sbjct: 394 KEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKE-PA 452
Query: 67 EEKEGEKDAAAAKEEAPKA-EPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEA 125
E KE AP EP T A P K P P E
Sbjct: 453 PTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTK 512
Query: 126 AAAPAESAAPAAGEEPSKEEGEPKKTEAPA---APAAQETKSDGAPASDSKPGSS---EA 179
+P PA P+ + P T+ PA +A T + +P + +P + E
Sbjct: 513 EPSPTTPKEPA----PTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEP 568
Query: 180 APSSKETPAAT---EAPSSTPKAQGPAASAEEPKP 211
AP++ + PA T E +TPK P + ++P P
Sbjct: 569 APTTPKKPAPTTPKEPAPTTPKEPAP-TTTKKPAP 602
Score = 42.7 bits (99), Expect = 3e-04
Identities = 48/206 (23%), Positives = 74/206 (35%), Gaps = 21/206 (10%)
Query: 36 TPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKA-EPEKTEGAA 94
TPK + P EPA KE +G A E K+ APK P T+G
Sbjct: 753 TPKGTAPTTPKEPAPTTP-KEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPT 811
Query: 95 EAKAEPPKAPEQEQAAPG----PAAGGEAPKAAEAAAAP----AESAAPAAGEEP----- 141
++ P ++ AP PA A P +E + P +EP
Sbjct: 812 STTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHK 871
Query: 142 SKEEGEPKKTEAPAAPAAQET-KSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQ 200
S +E P+ + P A + + K G P + + AA + T A + +
Sbjct: 872 SPDESTPELSAEPTPKALENSPKEPGVPTT-----KTPAATKPEMTTTAKDKTTERDLRT 926
Query: 201 GPAASAEEPKPVEAPAANSDQTVTVK 226
P + PK + A +++T K
Sbjct: 927 TPETTTAAPKMTKETATTTEKTTESK 952
Score = 33.9 bits (76), Expect = 0.12
Identities = 42/190 (22%), Positives = 62/190 (32%), Gaps = 18/190 (9%)
Query: 34 EGTPK--ESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEE---APKAEPE 88
E TPK E+ P+ P KP+ K +K E+D E APK E
Sbjct: 883 EPTPKALENSPKEPGVPTTKTPAATKPEMTTTAK--DKTTERDLRTTPETTTAAPKMTKE 940
Query: 89 K-------TEGAAEAKAEPPKAPEQEQAAPGPAAGGE----APKAAEAAAAPAESAAPAA 137
TE A + + P + APK +
Sbjct: 941 TATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNK 1000
Query: 138 GEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTP 197
EE +K + ++A + TK+ P S KP + K TP + S+ P
Sbjct: 1001 PEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMP 1060
Query: 198 KAQGPAASAE 207
+ + AE
Sbjct: 1061 ELNPTSRIAE 1070
>gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo
sapiens]
Length = 2524
Score = 63.2 bits (152), Expect = 2e-10
Identities = 67/237 (28%), Positives = 92/237 (38%), Gaps = 31/237 (13%)
Query: 16 DEKAKEKDKKAEGAATEEEGTP---KESEPQAAA---------EPAEA--KEGKEKPDQD 61
+ A+ K KKA AA+EE P ++ E +A+ E AEA G E P +
Sbjct: 676 ERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEALHASGNEVPRGE 735
Query: 62 AEGKAE-------EKEGEKDAAAAKEEAPKA-EPEKTEGAAEAKAEPPKAPEQEQAAPGP 113
G A E AAK+ +P T GA PP P ++ AP
Sbjct: 736 CSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPT- 794
Query: 114 AAGGEAPKAAEAAAAPAESAAPAAGEEPSKE-EGEPKKTEAPAAPAAQETKSDGAPASDS 172
E A+EA AP AP + P E K+ E AAP +E + PA++
Sbjct: 795 ----EPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEE 850
Query: 173 ---KPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVK 226
G +E S+ T A E P+ A+ A+AE E S + T K
Sbjct: 851 LAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAK 907
Score = 49.3 bits (116), Expect = 3e-06
Identities = 71/258 (27%), Positives = 90/258 (34%), Gaps = 79/258 (30%)
Query: 34 EGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKA----EEKEGEKDAAAAKEEAPKAEPEK 89
E P +EP A+E A P + EEKE E AA EE + +P
Sbjct: 788 EDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPA 847
Query: 90 TEGAA--EAKAEPPKAPE-QEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEE------ 140
E A KAE P E E+A GPA G K AEAA A AE A A +E
Sbjct: 848 AEELAVDTGKAEEPVKSECTEEAEEGPAKG----KDAEAAEATAEGALKAEKKEGGSGRA 903
Query: 141 -PSKEEGEPKKTEAPAAPAAQE----------------------TKSDGAPASDSKP--- 174
+K G P+ +++ A +A E T A AS KP
Sbjct: 904 TTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDL 963
Query: 175 --------------------GSSEAAPSSKETPA------------ATEAPSSTPKAQG- 201
+AAP+ PA A + P S+P+ +
Sbjct: 964 KQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSR 1023
Query: 202 ---PAASAEEPKPVEAPA 216
P A E KPV PA
Sbjct: 1024 SPAPPADKEAEKPVFFPA 1041
Score = 45.8 bits (107), Expect = 3e-05
Identities = 49/170 (28%), Positives = 67/170 (39%), Gaps = 29/170 (17%)
Query: 70 EGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAP 129
E E++A K++AP A A+E A PP ++E A G +G E EA A
Sbjct: 674 EKERNARRKKKKAPAA-------ASEEAAFPPVVEDEEMEASG-VSGNEEEMVEEAEALH 725
Query: 130 A--------ESAAPAAGEEPSKEEGEPKK-TEA--------PAAPAAQETKSDGAPASDS 172
A E + PA S E P TEA P PA +DG P
Sbjct: 726 ASGNEVPRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPAT--LGADGPPPGPP 783
Query: 173 KPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQT 222
P + ++ TPA+ + TP P+ SA P PV ++T
Sbjct: 784 TPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSA--PPPVVPKEEKEEET 831
Score = 36.2 bits (82), Expect = 0.024
Identities = 28/141 (19%), Positives = 62/141 (43%), Gaps = 10/141 (7%)
Query: 5 LSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEG 64
L+KK + Y + + + G + +++ ++ + Q +P +EK +++ E
Sbjct: 472 LTKKNENY----KSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEK 527
Query: 65 KAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKA-- 122
+AE++E + + KE+ K + + T G + E + ++ A G ++
Sbjct: 528 EAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMA 587
Query: 123 ----AEAAAAPAESAAPAAGE 139
+E A P +SA A+ E
Sbjct: 588 NEANSEEAITPQQSAELASME 608
Score = 28.5 bits (62), Expect = 4.9
Identities = 28/104 (26%), Positives = 36/104 (34%), Gaps = 4/104 (3%)
Query: 33 EEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEG 92
E+ P + P A P + + P Q + A + E P P
Sbjct: 986 EDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFP---AF 1042
Query: 93 AAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAP-AESAAP 135
AAEA+ P P P P E KA+ A P A S AP
Sbjct: 1043 AAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAP 1086
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 62.4 bits (150), Expect = 3e-10
Identities = 64/216 (29%), Positives = 89/216 (41%), Gaps = 30/216 (13%)
Query: 13 NVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGE 72
+V +++ K++ + A E + +P+AA E KE K KP E K EEKE
Sbjct: 601 SVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKP----EDKKEEKEKP 656
Query: 73 KDAAAAKE--------EAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAE 124
K A KE E PK E K E E K E K P++E P PK +
Sbjct: 657 KKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETP------PKEVK 710
Query: 125 AAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSS--EAAPS 182
E +E KEE EPKK E P ++ K P S++K ++ P
Sbjct: 711 KEVKKEEK------KEVKKEEKEPKK-EIKKLP--KDAKKSSTPLSEAKKPAALKPKVPK 761
Query: 183 SKETPAATEAPSSTPKAQGP-AASAEEPKPVEAPAA 217
+E+ + PK +G +E K EA AA
Sbjct: 762 KEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAA 797
Score = 53.1 bits (126), Expect = 2e-07
Identities = 58/209 (27%), Positives = 92/209 (44%), Gaps = 15/209 (7%)
Query: 8 KKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAK---EGKEKPDQDAEG 64
+K+ +V + AKEK K E E+ ++ +P+ E K + +EKP ++
Sbjct: 622 EKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVK 681
Query: 65 KAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAE 124
K +KE +K+ ++ K E E E K E K ++E+ P + PK A+
Sbjct: 682 KEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEI-KKLPKDAK 740
Query: 125 AAAAP-AESAAPAA--GEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPG-SSEAA 180
++ P +E+ PAA + P KEE K + A P K G K G ++EA
Sbjct: 741 KSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKP-----KEKGKIKVIKKEGKAAEAV 795
Query: 181 PSSKETPAATEAPSSTP--KAQGPAASAE 207
++ T A T A + A GPA E
Sbjct: 796 AAAVGTGATTAAVMAAAGIAAIGPAKELE 824
Score = 49.7 bits (117), Expect = 2e-06
Identities = 45/188 (23%), Positives = 79/188 (42%), Gaps = 5/188 (2%)
Query: 16 DEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKE-KPDQDAEGKAEEKEGEKD 74
++K +EK+K + A +E+ TP + E + E + + KE K ++ E K E K+
Sbjct: 647 EDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPP 706
Query: 75 AAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESA- 133
KE + + E + E K E K P+ + + P + + P A + E +
Sbjct: 707 KEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESV 766
Query: 134 ---APAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAAT 190
+ AAG+ K + + K E AA A GA + + AA + A
Sbjct: 767 KKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAE 826
Query: 191 EAPSSTPK 198
+ S+P+
Sbjct: 827 RSLMSSPE 834
Score = 46.6 bits (109), Expect = 2e-05
Identities = 58/243 (23%), Positives = 90/243 (37%), Gaps = 39/243 (16%)
Query: 4 KLSKKKKGYNVNDEKA--KEKDKKAEGAATEEEG-----------TPKESEPQAAAEPAE 50
K + G+ + E +EK + E EE+G +P E E A AE
Sbjct: 925 KFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADA 984
Query: 51 AKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAA 110
K + + +AEE + D A K EA ++E E E E KAE + E E
Sbjct: 985 YIREKRESVASGDDRAEE---DMDEAIEKGEAEQSEEEADE---EDKAEDAREEEYEP-- 1036
Query: 111 PGPAAGGEAPKAAEAAAAPAESAAPAAGEE--------PSKEEGEPKKTEAPAAPAAQET 162
E +A + A + AA A G E P+K+ G PA+ ET
Sbjct: 1037 -------EKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDET 1089
Query: 163 KSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEE---PKPVEAPAANS 219
G+ + + +E A + ST + +E P+ V + N+
Sbjct: 1090 LPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNN 1149
Query: 220 DQT 222
++T
Sbjct: 1150 EET 1152
Score = 44.3 bits (103), Expect = 9e-05
Identities = 44/209 (21%), Positives = 76/209 (36%), Gaps = 17/209 (8%)
Query: 27 EGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAE 86
E A E + +E A+ A+E ++ + E + E+E +++ A + E
Sbjct: 976 ESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYE 1035
Query: 87 PEKTEGAAEAKAEPPKAPE----QEQ----AAPGPAAGGEAPKAAEAAA-----APAESA 133
PEK E A KA E +EQ P G ++P A++ P S
Sbjct: 1036 PEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSE 1095
Query: 134 APAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAP 193
+ A + E +P++ A + + P + + S + TE+P
Sbjct: 1096 SEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESP 1155
Query: 194 S----STPKAQGPAASAEEPKPVEAPAAN 218
S + K + S E KP + N
Sbjct: 1156 SQEFVNITKYESSLYSQEYSKPADVTPLN 1184
Score = 43.9 bits (102), Expect = 1e-04
Identities = 60/248 (24%), Positives = 98/248 (39%), Gaps = 39/248 (15%)
Query: 5 LSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEG 64
+ K++K +K +K+ K E ++ KE+ P+ + + +E KE ++ E
Sbjct: 669 IKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEP 728
Query: 65 KAEEKEGEKDA-------------AAAKEEAPKAEPE-----------KTEGAAEAKAEP 100
K E K+ KDA AA K + PK E K +G + +
Sbjct: 729 KKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKE 788
Query: 101 PKAPEQEQAAPGPAAGGEAPKAAEAAAA-------PAESAAPAAGEEPSKEEGEPKKTEA 153
KA E AA G A A AA AA AE + ++ E+ +K+ E K E
Sbjct: 789 GKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEV 848
Query: 154 PAAPAAQ---ETKSDGAPASDSKPGSSEAAPSSKE-TPAATEAPS---STPKAQGPA-AS 205
+ E D +++P + +E T E+P +T + +G +
Sbjct: 849 DVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQT 908
Query: 206 AEEPKPVE 213
EE +PVE
Sbjct: 909 PEELEPVE 916
Score = 43.9 bits (102), Expect = 1e-04
Identities = 55/233 (23%), Positives = 92/233 (39%), Gaps = 35/233 (15%)
Query: 19 AKEKDKKAEGAATEEEGTPK------------ESEPQAAAEPAEAKEGKEKPDQDAEGKA 66
++E +++E T+ G P E+ P + +E A ++ + P + E +
Sbjct: 2112 SEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPS 2171
Query: 67 EEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAA 126
+ D+ E P +KT +PP AP Q+++ P P + EA
Sbjct: 2172 ITADANIDSEDESETIPT---DKT--VTYKHMDPPPAPVQDRS-PSPRHPDVSMVDPEAL 2225
Query: 127 AAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAP---ASDSKPG-------- 175
A E A ++ KE+ + KK ++ KSDG A+ KP
Sbjct: 2226 AI--EQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDK 2283
Query: 176 -SSEAAPSSKETPAATEAPSSTPK---AQGPAASAEEPKPVEAPAANSDQTVT 224
S A+P KE+ P++TP+ A+G E A A+ S +T T
Sbjct: 2284 VSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTAT 2336
Score = 43.5 bits (101), Expect = 1e-04
Identities = 49/190 (25%), Positives = 76/190 (40%), Gaps = 32/190 (16%)
Query: 22 KDKKAEGAATEEEGTPKESEPQAA----AEPAEAKEGKEKPDQ-----DAEGKAE----- 67
KD K + E+E KE+EP A E K E PD+ + EG+ E
Sbjct: 852 KDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEE 911
Query: 68 ----EKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQ----------AAPGP 113
EK+G D ++E E G E KAE +A E E+ + P
Sbjct: 912 LEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSP 971
Query: 114 AAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEG----EPKKTEAPAAPAAQETKSDGAPA 169
E+ KA A + + A+G++ ++E+ E + E A +E K++ A
Sbjct: 972 TEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDARE 1031
Query: 170 SDSKPGSSEA 179
+ +P EA
Sbjct: 1032 EEYEPEKMEA 1041
Score = 41.2 bits (95), Expect = 7e-04
Identities = 51/211 (24%), Positives = 79/211 (37%), Gaps = 27/211 (12%)
Query: 21 EKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKE 80
EK K E ++E+ K+ +P E KE P ++ + + EK A K
Sbjct: 575 EKPPKVE---SKEKVMVKKDKPIKTETKPSVTE-KEVPSKEEPSPVKAEVAEKQATDVK- 629
Query: 81 EAPKAEPEK-----TEGAAEAKAEPPKAPEQEQAA---PGPAAGGEAPKAAEAAAAPAES 132
PKA EK T+ E K E + P++E A P E PK E +
Sbjct: 630 --PKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKE 687
Query: 133 AAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEA 192
+EP KE K E P +E K + + K E KE +
Sbjct: 688 IKKEEKKEPKKE----VKKETPPKEVKKEVKKE-----EKKEVKKEEKEPKKE---IKKL 735
Query: 193 PSSTPKAQGPAASAEEPKPVEAPAANSDQTV 223
P K+ P + A++P ++ +++V
Sbjct: 736 PKDAKKSSTPLSEAKKPAALKPKVPKKEESV 766
Score = 39.7 bits (91), Expect = 0.002
Identities = 42/140 (30%), Positives = 60/140 (42%), Gaps = 21/140 (15%)
Query: 18 KAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAA 77
KA +KD K E T++ GT +S + P + +GK KP + A KE +
Sbjct: 2233 KALKKDLK-EKTKTKKPGTKTKS-----SSPVKKSDGKSKPLAASPKPAGLKESSDKVSR 2286
Query: 78 AKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAA 137
A P+K E + E A+P PE +AA G E AA A+A+ + A A
Sbjct: 2287 V------ASPKKKE-SVEKAAKPTTTPE-VKAARGEEKDKETKNAANASASKSAKTATAG 2338
Query: 138 GEEPSKEEGEPKKTEAPAAP 157
G K T++ A P
Sbjct: 2339 -------PGTTKTTKSSAVP 2351
Score = 37.7 bits (86), Expect = 0.008
Identities = 29/92 (31%), Positives = 35/92 (38%), Gaps = 8/92 (8%)
Query: 131 ESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAAT 190
ES PAA PSK + K E P + K S E K+ P T
Sbjct: 543 ESLKPAAKPLPSKSVRKESKEETPEVTKVNHVE------KPPKVESKEKVMVKKDKPIKT 596
Query: 191 EAPSSTPKAQGPAASAEEPKPVEAPAANSDQT 222
E S + + P S EEP PV+A A T
Sbjct: 597 ETKPSVTEKEVP--SKEEPSPVKAEVAEKQAT 626
Score = 33.1 bits (74), Expect = 0.20
Identities = 39/185 (21%), Positives = 74/185 (40%), Gaps = 16/185 (8%)
Query: 21 EKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEK-PDQ---DAEGKAEEKEGEKDAA 76
+ + ++E T++ T K +P A P + + + PD D E A E+ K
Sbjct: 2179 DSEDESETIPTDKTVTYKHMDPPPA--PVQDRSPSPRHPDVSMVDPEALAIEQNLGK--- 2233
Query: 77 AAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQ----AAPGPAAGGEAPKAAEAAAAPAES 132
A K++ + K G + P K + + A+P PA E+ A+P +
Sbjct: 2234 ALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKK 2293
Query: 133 AAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEA 192
+ E+ +K P+ A +ETK+ ++ ++ A P + +T ++
Sbjct: 2294 ESV---EKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKSSAV 2350
Query: 193 PSSTP 197
P P
Sbjct: 2351 PPGLP 2355
>gi|42518068 trans-golgi network protein 2 [Homo sapiens]
Length = 437
Score = 62.4 bits (150), Expect = 3e-10
Identities = 52/205 (25%), Positives = 88/205 (42%), Gaps = 13/205 (6%)
Query: 28 GAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQD-AEGKAEEKEGEKDAAAAKEEAPKAE 86
G +T+ P+ + + AEA+ ++ P++ AE K ++ K A AK + K
Sbjct: 51 GGSTKSHPEPQTPKDSPSKSSAEAQTPEDTPNKSGAEAKTQKDSSNKSGAEAKTQ--KGS 108
Query: 87 PEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEE--PSKE 144
K+ A+ + E P + G +A +P S A A ++ PSK
Sbjct: 109 TSKSGSEAQTTKDSTSKSHPELQTPKDSTGKSGAEAQTPEDSPNRSGAEAKTQKDSPSKS 168
Query: 145 EGEPKKT-EAPAAPAAQ-ETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGP 202
E + T + P A +T DG+ SK G+ + P K+ P + A TPK
Sbjct: 169 GSEAQTTKDVPNKSGADGQTPKDGS----SKSGAEDQTP--KDVPNKSGAEKQTPKDGSN 222
Query: 203 AASAEEPKPVEAPAANSDQTVTVKE 227
+ AEE P++ P+ + + T K+
Sbjct: 223 KSGAEEQGPIDGPSKSGAEEQTSKD 247
Score = 48.1 bits (113), Expect = 6e-06
Identities = 49/233 (21%), Positives = 92/233 (39%), Gaps = 26/233 (11%)
Query: 8 KKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEG-KA 66
++ G + + K + ++ E TP+++ ++ AE K+ K +A+ K
Sbjct: 48 QRPGGSTKSHPEPQTPKDSPSKSSAEAQTPEDTPNKSGAEAKTQKDSSNKSGAEAKTQKG 107
Query: 67 EEKEGEKDAAAAKEEAPKAEPE-----KTEGAAEAKAEPPK-------APEQEQAAPGPA 114
+ +A K+ K+ PE + G + A+A+ P+ A + Q
Sbjct: 108 STSKSGSEAQTTKDSTSKSHPELQTPKDSTGKSGAEAQTPEDSPNRSGAEAKTQKDSPSK 167
Query: 115 AGGEAPKAAEAA-AAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSK 173
+G EA + + A+ P G S E + K + A ++T DG+ +K
Sbjct: 168 SGSEAQTTKDVPNKSGADGQTPKDGSSKSGAEDQTPKDVPNKSGAEKQTPKDGS----NK 223
Query: 174 PGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEP------KPVEAPAANSD 220
G+ E P + P+ + A T K E+P KP+ P+ N +
Sbjct: 224 SGAEEQGPI--DGPSKSGAEEQTSKDSPNKVVPEQPSRKDHSKPISNPSDNKE 274
Score = 47.0 bits (110), Expect = 1e-05
Identities = 47/202 (23%), Positives = 76/202 (37%), Gaps = 17/202 (8%)
Query: 42 PQAAAEPAEAKEGKEKPDQ---DAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKA 98
P A E + +E +P ++ G + + + PK P K+ A+
Sbjct: 19 PLLATESVKQEEAGVRPSAGNVSTHPSLSQRPGGSTKSHPEPQTPKDSPSKSSAEAQTPE 78
Query: 99 EPPK---APEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGE---PK--- 149
+ P A + Q +G EA K + + + + S A + SK E PK
Sbjct: 79 DTPNKSGAEAKTQKDSSNKSGAEA-KTQKGSTSKSGSEAQTTKDSTSKSHPELQTPKDST 137
Query: 150 -KTEAPAAPAAQETKSDGAPA---SDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAAS 205
K+ A A GA A DS S A ++K+ P + A TPK +
Sbjct: 138 GKSGAEAQTPEDSPNRSGAEAKTQKDSPSKSGSEAQTTKDVPNKSGADGQTPKDGSSKSG 197
Query: 206 AEEPKPVEAPAANSDQTVTVKE 227
AE+ P + P + + T K+
Sbjct: 198 AEDQTPKDVPNKSGAEKQTPKD 219
Score = 45.1 bits (105), Expect = 5e-05
Identities = 42/182 (23%), Positives = 76/182 (41%), Gaps = 21/182 (11%)
Query: 22 KDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAE--EKEGEKDAAAAK 79
KD ++ A E+ TPK+ ++ AE K+G K + +G + K G ++ + K
Sbjct: 190 KDGSSKSGA--EDQTPKDVPNKSGAEKQTPKDGSNKSGAEEQGPIDGPSKSGAEEQTS-K 246
Query: 80 EEAPKAEPEKTEGAAEAKA--------EPPKAPEQEQAAPGPAA-------GGEAPKAAE 124
+ K PE+ +K E PKA + A G + GE
Sbjct: 247 DSPNKVVPEQPSRKDHSKPISNPSDNKELPKADTNQLADKGKLSPHAFKTESGEETDLIS 306
Query: 125 AAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGS-SEAAPSS 183
+S+ P EP + E + E + P ++ K G+ +S+++ G+ S++ S
Sbjct: 307 PPQEEVKSSEPTEDVEPKEAEDDDTGPEEGSPPKEEKEKMSGSASSENREGTLSDSTGSE 366
Query: 184 KE 185
K+
Sbjct: 367 KD 368
Score = 43.5 bits (101), Expect = 1e-04
Identities = 47/235 (20%), Positives = 89/235 (37%), Gaps = 17/235 (7%)
Query: 3 GKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEP-----------AEA 51
G +K +KG + K + + E TPK+S ++ AE AEA
Sbjct: 99 GAEAKTQKGSTSKSGSEAQTTKDSTSKSHPELQTPKDSTGKSGAEAQTPEDSPNRSGAEA 158
Query: 52 KEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAP 111
K K+ P + +A+ + + + A + PK K+ + + P E+ P
Sbjct: 159 KTQKDSPSKSG-SEAQTTKDVPNKSGADGQTPKDGSSKSGAEDQTPKDVPNKSGAEKQTP 217
Query: 112 GPAAGGEAPKAAEAAAAPAESAA--PAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPA 169
+ + P++S A + + P+K E + + P + + + P
Sbjct: 218 KDGSNKSGAEEQGPIDGPSKSGAEEQTSKDSPNKVVPEQPSRKDHSKPISNPSDNKELPK 277
Query: 170 SDSK--PGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQT 222
+D+ + +P + +T + E +P Q S+E + VE A D T
Sbjct: 278 ADTNQLADKGKLSPHAFKTESGEETDLISP-PQEEVKSSEPTEDVEPKEAEDDDT 331
Score = 35.0 bits (79), Expect = 0.053
Identities = 38/174 (21%), Positives = 66/174 (37%), Gaps = 29/174 (16%)
Query: 33 EEGTPKESEPQAAAEP-----------AEAKEGKEKPDQDAEGKAEEKEGEKDAA--AAK 79
E+ TPK+ ++ AE AE + K+ P++ + K+ K + +
Sbjct: 213 EKQTPKDGSNKSGAEEQGPIDGPSKSGAEEQTSKDSPNKVVPEQPSRKDHSKPISNPSDN 272
Query: 80 EEAPKAEPE-------------KTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAA 126
+E PKA+ KTE E P P++E + P E +A +
Sbjct: 273 KELPKADTNQLADKGKLSPHAFKTESGEETDLISP--PQEEVKSSEPTEDVEPKEAEDDD 330
Query: 127 AAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAA 180
P E + P +E + E + + K D P + S GS+E++
Sbjct: 331 TGPEEGSPPKEEKEKMSGSASSENREGTLSDSTGSEKDDLYP-NGSGNGSAESS 383
>gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]
Length = 825
Score = 62.0 bits (149), Expect = 4e-10
Identities = 63/211 (29%), Positives = 94/211 (44%), Gaps = 24/211 (11%)
Query: 26 AEGAATE-EEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAE---EKEGEKDAAAAKEE 81
AE A TE + PKE+ + A+ + E P + +A +E + A A+ +
Sbjct: 450 AEEAPTEFQSPLPKETTAEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEAHAEVQ 509
Query: 82 APKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAA--APAESAAPAAG- 138
+P AE E EA AE E A A ++P + E +A APAE +P+A
Sbjct: 510 SPLAEETTAE---EASAEIQLLAAIEAPADETPAEAQSPLSEETSAEEAPAEVQSPSAKG 566
Query: 139 ----------EEPSKEEGEPKKTEAP-AAPAAQETKSDGAPASDSKPGSSEAAPSSKETP 187
+ PS EE ++ A AA E ++ APA + +P +E AP+ + P
Sbjct: 567 VSIEEAPLELQPPSGEETTAEEASAAIQLLAATEASAEEAPA-EVQPPPAEEAPAEVQPP 625
Query: 188 AATEAPSST--PKAQGPAASAEEPKPVEAPA 216
A EAP+ P A+ A + P EAPA
Sbjct: 626 PAEEAPAEVQPPPAEEAPAEVQPPPAEEAPA 656
Score = 61.6 bits (148), Expect = 5e-10
Identities = 66/222 (29%), Positives = 92/222 (41%), Gaps = 31/222 (13%)
Query: 22 KDKKAEGAATEEEGTPKESEPQAAAEPAEAKE--GKEKPDQDA----------EGKAEEK 69
K+ AE A+ E + +EP A PAEA+ +E ++A E AEE
Sbjct: 463 KETTAEEASAEIQ-LLAATEPPADETPAEARSPLSEETSAEEAHAEVQSPLAEETTAEEA 521
Query: 70 EGEKDAAAAKEEAPKAEPEKTEG--AAEAKAEPPKAPEQEQAAPG-----------PAAG 116
E AA E P + + + E AE A Q +A G P +G
Sbjct: 522 SAEIQLLAAIEAPADETPAEAQSPLSEETSAEEAPAEVQSPSAKGVSIEEAPLELQPPSG 581
Query: 117 GEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGS 176
E +AA +A A+ EE E P EAPA Q ++ APA + +P
Sbjct: 582 EETTAEEASAAIQLLAATEASAEEAPAEVQPPPAEEAPAE--VQPPPAEEAPA-EVQPPP 638
Query: 177 SEAAPSSKETPAATEAPSST--PKAQGPAASAEEPKPVEAPA 216
+E AP+ + P A EAP+ P A+ A + P EAPA
Sbjct: 639 AEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPA 680
Score = 57.8 bits (138), Expect = 8e-09
Identities = 67/223 (30%), Positives = 100/223 (44%), Gaps = 28/223 (12%)
Query: 14 VNDEKAKEKDKKAEGAATEEEGTPKESEPQ-----AAAEPAEAKEGKEKPDQDAEGKAEE 68
+++E + E+ + EE T +E+ + A PA+ + + E AEE
Sbjct: 495 LSEETSAEEAHAEVQSPLAEETTAEEASAEIQLLAAIEAPADETPAEAQSPLSEETSAEE 554
Query: 69 KEGEKDAAAAK----EEAP-KAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAA 123
E + +AK EEAP + +P E E AE A Q AA A+ EAP
Sbjct: 555 APAEVQSPSAKGVSIEEAPLELQPPSGE---ETTAEEASAAIQLLAAT-EASAEEAPAEV 610
Query: 124 E---AAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAA 180
+ A APAE P A E P++ + P + EAPA Q ++ APA + +P +E A
Sbjct: 611 QPPPAEEAPAEVQPPPAEEAPAEVQPPPAE-EAPAE--VQPPPAEEAPA-EVQPPPAEEA 666
Query: 181 PSSKETPAATEAPS---STPKAQGP----AASAEEPKPVEAPA 216
P+ + P A EAP+ S P + P A+ P + PA
Sbjct: 667 PAEVQPPPAEEAPAEVQSLPAEETPIEETLAAVHSPPADDVPA 709
Score = 56.6 bits (135), Expect = 2e-08
Identities = 57/206 (27%), Positives = 85/206 (41%), Gaps = 32/206 (15%)
Query: 42 PQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE---AKA 98
P A P+E + P + + E GE + +A++ + +P EGA E AK
Sbjct: 353 PSAEESPSEEPPAEILPPPAEKSPSVELLGEIRSPSAQKAPIEVQPLPAEGALEEAPAKV 412
Query: 99 EPPKAPEQEQAAPGPAAGGEAPKA------------AEAAAAPAESAAPAAGEEPSKEEG 146
EPP E+ A P EAP+ A AP E +P E ++E
Sbjct: 413 EPPTV-EETLADVQPLLPEEAPREEARELQLSTAMETPAEEAPTEFQSPLPKETTAEEAS 471
Query: 147 ---------EPKKTEAPA---APAAQETKSDGAPASDSKP----GSSEAAPSSKETPAAT 190
EP E PA +P ++ET ++ A A P ++E A + + AA
Sbjct: 472 AEIQLLAATEPPADETPAEARSPLSEETSAEEAHAEVQSPLAEETTAEEASAEIQLLAAI 531
Query: 191 EAPSSTPKAQGPAASAEEPKPVEAPA 216
EAP+ A+ + +EE EAPA
Sbjct: 532 EAPADETPAEAQSPLSEETSAEEAPA 557
Score = 52.0 bits (123), Expect = 4e-07
Identities = 58/204 (28%), Positives = 83/204 (40%), Gaps = 13/204 (6%)
Query: 13 NVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEP-AEAKEGKEKPDQDAEGKAEEKEG 71
+ + A+ + A+G + EE P E +P + E AE + E AEE
Sbjct: 551 SAEEAPAEVQSPSAKGVSIEE--APLELQPPSGEETTAEEASAAIQLLAATEASAEEAPA 608
Query: 72 EKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAE 131
E A+E + +P E A A+ +PP A E+ A P EAP AE PAE
Sbjct: 609 EVQPPPAEEAPAEVQPPPAE-EAPAEVQPPPA-EEAPAEVQPPPAEEAP--AEVQPPPAE 664
Query: 132 SAAPAAGEEPSKEEGEPKKTEAPA--APAAQETKSDGAPASDSKPGSSEAAPSSKETPAA 189
APA + P EE + PA P + + +P +D P + EA+ PA
Sbjct: 665 E-APAEVQPPPAEEAPAEVQSLPAEETPIEETLAAVHSPPADDVP-AEEASVDKHSPPAD 722
Query: 190 TEAPSSTPKAQGPAASAEEPKPVE 213
P G A++ P P E
Sbjct: 723 LLLTEEFP--IGEASAEVSPPPSE 744
Score = 50.4 bits (119), Expect = 1e-06
Identities = 54/197 (27%), Positives = 79/197 (40%), Gaps = 16/197 (8%)
Query: 18 KAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAA 77
+A + AE + E T E P P+ E+ + + + E+ ++A+A
Sbjct: 532 EAPADETPAEAQSPLSEETSAEEAPAEVQSPSAKGVSIEEAPLELQPPSGEETTAEEASA 591
Query: 78 AKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAA 137
A + E E AE +PP A E+ A P EAP AE PAE A PA
Sbjct: 592 AIQLLAATEASAEEAPAEV--QPPPA-EEAPAEVQPPPAEEAP--AEVQPPPAEEA-PAE 645
Query: 138 GEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSS----KETPAATEAP 193
+ P EE + PA A E + P ++ P ++ P+ +ET AA +P
Sbjct: 646 VQPPPAEEAPAEVQPPPAEEAPAEVQ---PPPAEEAPAEVQSLPAEETPIEETLAAVHSP 702
Query: 194 SSTPKAQGPAASAEEPK 210
P PA A K
Sbjct: 703 ---PADDVPAEEASVDK 716
Score = 49.3 bits (116), Expect = 3e-06
Identities = 53/192 (27%), Positives = 71/192 (36%), Gaps = 10/192 (5%)
Query: 16 DEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDA 75
DE E + EE + P A E + +P E AEE
Sbjct: 536 DETPAEAQSPLSEETSAEEAPAEVQSPSAKGVSIEEAPLELQPPSGEETTAEEASAAIQL 595
Query: 76 AAAKEEAPKAEPEKTEGA----AEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAE 131
AA E + + P + + A A+ +PP A E+ A P EAP AE PAE
Sbjct: 596 LAATEASAEEAPAEVQPPPAEEAPAEVQPPPA-EEAPAEVQPPPAEEAP--AEVQPPPAE 652
Query: 132 SAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATE 191
A PA + P EE + PA A E +S PA ++ + AA S
Sbjct: 653 EA-PAEVQPPPAEEAPAEVQPPPAEEAPAEVQS--LPAEETPIEETLAAVHSPPADDVPA 709
Query: 192 APSSTPKAQGPA 203
+S K PA
Sbjct: 710 EEASVDKHSPPA 721
Score = 48.9 bits (115), Expect = 4e-06
Identities = 49/194 (25%), Positives = 76/194 (39%), Gaps = 15/194 (7%)
Query: 33 EEGTPKESEPQAAAEPAEAKE--GKEKPD--QDAEGKAEEKEGEK---DAAAAKEEAPKA 85
+EG+ + A EP ++ K +P ++A KAE + E+ + EE P A
Sbjct: 244 QEGSAVKKVASAEIEPPSTEKFPAKIQPPLVEEATAKAEPRPAEETHVQVQPSTEETPDA 303
Query: 86 EPEKTEGAAEAKAEPPKAPE----QEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEP 141
E K +PP A E + A P + E+P A SA + EEP
Sbjct: 304 EAATAVAENSVKVQPPPAEEAPLVEFPAEIQPPSAEESPSVELLAEILPPSAEESPSEEP 363
Query: 142 SKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQG 201
E P ++P+ E +S A + + A + +E PA E P+ +
Sbjct: 364 PAEILPPPAEKSPSVELLGEIRSPSAQKAPIEVQPLPAEGALEEAPAKVEPPT----VEE 419
Query: 202 PAASAEEPKPVEAP 215
A + P EAP
Sbjct: 420 TLADVQPLLPEEAP 433
Score = 47.8 bits (112), Expect = 8e-06
Identities = 49/196 (25%), Positives = 74/196 (37%), Gaps = 20/196 (10%)
Query: 16 DEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDA 75
+E E+ A E + +E+ + PAE + +P E AE + +
Sbjct: 582 EETTAEEASAAIQLLAATEASAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEE 641
Query: 76 AAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESA-- 133
A A+ + P AE A A+ +PP A E+ A P EAP AE + PAE
Sbjct: 642 APAEVQPPPAE------EAPAEVQPPPA-EEAPAEVQPPPAEEAP--AEVQSLPAEETPI 692
Query: 134 --------APAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKE 185
+P A + P+ EE K PA E G +++ P SE P +
Sbjct: 693 EETLAAVHSPPADDVPA-EEASVDKHSPPADLLLTEEFPIGEASAEVSPPPSEQTPEDEA 751
Query: 186 TPAATEAPSSTPKAQG 201
+P+ G
Sbjct: 752 LVENVSTEFQSPQVAG 767
Score = 45.1 bits (105), Expect = 5e-05
Identities = 50/180 (27%), Positives = 69/180 (38%), Gaps = 28/180 (15%)
Query: 67 EEKEGEKDAAAAKEEAPKAE--PEKTEGA----AEAKAEPPKA--------PEQEQAAPG 112
+E K A+A+ E P E P K + A AKAEP A P E+
Sbjct: 244 QEGSAVKKVASAEIEPPSTEKFPAKIQPPLVEEATAKAEPRPAEETHVQVQPSTEETPDA 303
Query: 113 PAAGGEAPKAAEAAAAPAESAA----PAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAP 168
AA A + + PAE A PA + PS EE + A P + E P
Sbjct: 304 EAATAVAENSVKVQPPPAEEAPLVEFPAEIQPPSAEESPSVELLAEILPPSAEESPSEEP 363
Query: 169 ASDSKPGSSEAAPSSK-----ETPAATEAPSSTPKAQGPAASAE-----EPKPVEAPAAN 218
++ P +E +PS + +P+A +AP A E EP VE A+
Sbjct: 364 PAEILPPPAEKSPSVELLGEIRSPSAQKAPIEVQPLPAEGALEEAPAKVEPPTVEETLAD 423
Score = 44.7 bits (104), Expect = 7e-05
Identities = 58/224 (25%), Positives = 82/224 (36%), Gaps = 19/224 (8%)
Query: 13 NVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGE 72
+V + + E+ AE A E + K P A P + +P E + E E
Sbjct: 290 HVQVQPSTEETPDAEAATAVAENSVKVQPPPAEEAPLVEFPAEIQPPSAEESPSVELLAE 349
Query: 73 KDAAAAKE---EAPKAE----PEKTEGAAEAKAE-----PPKAPEQEQAAPGPAAGGEAP 120
+A+E E P AE P + + E E KAP + Q P A EAP
Sbjct: 350 ILPPSAEESPSEEPPAEILPPPAEKSPSVELLGEIRSPSAQKAPIEVQPLPAEGALEEAP 409
Query: 121 KAAEAAAAPAESA--APAAGEEPSKEEGEPKKT----EAPAAPAAQETKSDGAPASDSKP 174
E A P EE +EE + E PA A E +S + ++
Sbjct: 410 AKVEPPTVEETLADVQPLLPEEAPREEARELQLSTAMETPAEEAPTEFQSPLPKETTAEE 469
Query: 175 GSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEP-KPVEAPAA 217
S+E + P A E P+ SAEE V++P A
Sbjct: 470 ASAEIQLLAATEPPADETPAEARSPLSEETSAEEAHAEVQSPLA 513
Score = 44.7 bits (104), Expect = 7e-05
Identities = 55/193 (28%), Positives = 79/193 (40%), Gaps = 15/193 (7%)
Query: 26 AEGAATEEEGTPKESEPQAAAEPAEAKEG---KEKPDQDAEGKAEEKEGEKDAAAAKEEA 82
AEGA E P + EP E + +E P ++A E A A E
Sbjct: 401 AEGALEE---APAKVEPPTVEETLADVQPLLPEEAPREEARELQLSTAMETPAEEAPTEF 457
Query: 83 PKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAA--APAESAAPAAGEE 140
P++T A EA AE E A A +P + E +A A AE +P A E
Sbjct: 458 QSPLPKETT-AEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEAHAEVQSPLAEET 516
Query: 141 PSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAA-----TEAPSS 195
++E + A A ET ++ A + S+ S+E AP+ ++P+A EAP
Sbjct: 517 TAEEASAEIQLLAAIEAPADETPAE-AQSPLSEETSAEEAPAEVQSPSAKGVSIEEAPLE 575
Query: 196 TPKAQGPAASAEE 208
G +AEE
Sbjct: 576 LQPPSGEETTAEE 588
Score = 44.7 bits (104), Expect = 7e-05
Identities = 50/203 (24%), Positives = 77/203 (37%), Gaps = 14/203 (6%)
Query: 6 SKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKE--SEPQAAAEPAEAKEGKEKPDQDAE 63
S KG ++ + + + E EE + + +A+AE A A+ +P E
Sbjct: 561 SPSAKGVSIEEAPLELQPPSGEETTAEEASAAIQLLAATEASAEEAPAEV---QPPPAEE 617
Query: 64 GKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAA 123
AE + + A A+ + P AE A A+ +PP A E+ A P EAP A
Sbjct: 618 APAEVQPPPAEEAPAEVQPPPAE------EAPAEVQPPPA-EEAPAEVQPPPAEEAP--A 668
Query: 124 EAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSS 183
E PAE A P++E + A +P A + ++ A P +
Sbjct: 669 EVQPPPAEEAPAEVQSLPAEETPIEETLAAVHSPPADDVPAEEASVDKHSPPADLLLTEE 728
Query: 184 KETPAATEAPSSTPKAQGPAASA 206
A+ S P Q P A
Sbjct: 729 FPIGEASAEVSPPPSEQTPEDEA 751
Score = 37.4 bits (85), Expect = 0.011
Identities = 53/226 (23%), Positives = 82/226 (36%), Gaps = 35/226 (15%)
Query: 32 EEEGTPKESEPQAAAEPAEAKEGKEKPD---QDAEGK--AEEKEGEKDAAAAKEEAPKAE 86
E++ ESE + P ++ K K D + GK A E + A + EE +
Sbjct: 154 EQQTYFSESEIVVISRP-DSSSTKSKEDALKHKSSGKIFASEHPEFQPATNSNEEIGQKN 212
Query: 87 PEKTEGAAEAKAEPPKAPE----QEQAAPGPAAGGEAPKAAEAAAAP-------AESAAP 135
+T E K PP E +E P G K A A P A+ P
Sbjct: 213 ISRTSFTQETKKGPPVLLEDELREEVTVPVVQEGSAVKKVASAEIEPPSTEKFPAKIQPP 272
Query: 136 AAGEEPSKEEGEP-KKTEAPAAPAAQETKSDGAPASDSK-------PGSSEAA------- 180
E +K E P ++T P+ +ET A + ++ P + EA
Sbjct: 273 LVEEATAKAEPRPAEETHVQVQPSTEETPDAEAATAVAENSVKVQPPPAEEAPLVEFPAE 332
Query: 181 ---PSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTV 223
PS++E+P+ P + + S E P + P A +V
Sbjct: 333 IQPPSAEESPSVELLAEILPPSAEESPSEEPPAEILPPPAEKSPSV 378
>gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 1 [Homo sapiens]
Length = 559
Score = 60.1 bits (144), Expect = 2e-09
Identities = 49/208 (23%), Positives = 89/208 (42%), Gaps = 15/208 (7%)
Query: 21 EKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKE 80
+K K + G+ + + K S+P KE +E+P +D+E K+ KE E++ A + +
Sbjct: 173 KKTKPSHGSKDANKESSKTSKPHKVT-----KEHRERPRKDSESKSSSKELEREQAKSSK 227
Query: 81 EAPKAEPEKTEGAAEAKAEPPKAP--EQEQAAPGPAAGGEAPKAAEAAAAP----AESAA 134
+ + E E KA PPKA E + A +PK P A S
Sbjct: 228 DTSRKLGEGRL-PKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKR 286
Query: 135 PAAGEEPSKEEGEPKKTEAP---AAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATE 191
PA + P + KK+ + +AP S + SD KP +++ ++ A +E
Sbjct: 287 PATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESE 346
Query: 192 APSSTPKAQGPAASAEEPKPVEAPAANS 219
+ + +++E+ ++ +A S
Sbjct: 347 PREAKKALEVEESNSEDEASFKSESAQS 374
Score = 47.4 bits (111), Expect = 1e-05
Identities = 50/220 (22%), Positives = 97/220 (44%), Gaps = 18/220 (8%)
Query: 6 SKKKKGYNVNDEKAKE--KDKKAEGAATEEEGTPKESEPQAAAEPAEA---KEGKEKPDQ 60
SK K + V E + KD +++ ++ E E +S + + E KE K P +
Sbjct: 189 SKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPK 248
Query: 61 DA--EGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE--AKAEPPKAPEQEQ----AAPG 112
A E K KE + ++ + K P P +++ A A+ PK ++Q +
Sbjct: 249 AAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGS 308
Query: 113 PAAGGEAPKAAEAAA----APAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAP 168
+A G +P+ + +++ PA+ + GE+ K E EP++ + ++ + +
Sbjct: 309 RSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEK-VKAESEPREAKKALEVEESNSEDEASF 367
Query: 169 ASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEE 208
S+S S + SS ++ + ++ S +QGP S E
Sbjct: 368 KSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVE 407
Score = 42.4 bits (98), Expect = 3e-04
Identities = 31/189 (16%), Positives = 77/189 (40%), Gaps = 10/189 (5%)
Query: 20 KEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEK------ 73
K+K ++G+ + +P+ S + ++ AK+ + + ++E +E +K
Sbjct: 299 KQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEE 358
Query: 74 ----DAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAP 129
D A+ K E+ ++ P + ++++ ++ P Q + + E ++ E+
Sbjct: 359 SNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDD 418
Query: 130 AESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAA 189
+ S AAG+ + +++ + +A + P KP + S + +P +
Sbjct: 419 SSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPES 478
Query: 190 TEAPSSTPK 198
P K
Sbjct: 479 CSKPEKILK 487
Score = 36.6 bits (83), Expect = 0.018
Identities = 31/176 (17%), Positives = 70/176 (39%), Gaps = 10/176 (5%)
Query: 3 GKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDA 62
G + + +D+K + G + E P+E++ E + +++ + A
Sbjct: 313 GTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESA 372
Query: 63 EGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPE--QEQAAPGPAAGGEAP 120
+ D+++ + P ++G + E ++ E ++ ++ G A G+
Sbjct: 373 QSSPSNSSSSSDSSSDSDFEP--SQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTN 430
Query: 121 KAAEA--AAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKP 174
++ + + +ES A PS+E P+K P + + +P S SKP
Sbjct: 431 PGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNS----KVSGRRSPESCSKP 482
>gi|157738619 smoothelin-like 1 [Homo sapiens]
Length = 512
Score = 60.1 bits (144), Expect = 2e-09
Identities = 55/205 (26%), Positives = 82/205 (40%), Gaps = 13/205 (6%)
Query: 20 KEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEG--EKDAAA 77
++++ K+E EE+ + SE Q A E E +K D + K E K E+DA
Sbjct: 132 RKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEEDAKT 191
Query: 78 AKEEAP------KAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAE 131
A +E EP++ EAKAE KA +++A P + P E A A+
Sbjct: 192 ASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEP----KEPDGKEEAKHGAK 247
Query: 132 SAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATE 191
A A E EE EP ++ GA S P +P+ + +T+
Sbjct: 248 EEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGHNLSTD 307
Query: 192 APSSTPKAQGPAA-SAEEPKPVEAP 215
A G + SA E P + P
Sbjct: 308 GLGPDCVASGQTSPSASESSPSDVP 332
Score = 60.1 bits (144), Expect = 2e-09
Identities = 62/219 (28%), Positives = 99/219 (45%), Gaps = 45/219 (20%)
Query: 16 DEKAKEKDKKAEGAATEEEGTPKE--SEPQAAAEPAEAK----------EGKEKPDQDAE 63
+ KA +++ A+ A+ EE G KE +EP+ A EAK E K +P ++ +
Sbjct: 179 EPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEP-KEPD 237
Query: 64 GKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAE-----AKAEP-------PKAPEQEQAAP 111
GK E K G K+ A AKEEA AE + +E + EP P +PE+ +P
Sbjct: 238 GKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESP 297
Query: 112 ------------GP---AAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEP-KKTEAPA 155
GP A+G +P A+E++ + + P + K+E P ++ APA
Sbjct: 298 TGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPA 357
Query: 156 APAAQETKSDGAPASDSKPGSSEAAPSS--KETPAATEA 192
P ++ A K G + + P++ + T AA A
Sbjct: 358 RPRGP--RAQNRKAIVDKFGGAASGPTALFRNTKAAGAA 394
Score = 58.2 bits (139), Expect = 6e-09
Identities = 56/228 (24%), Positives = 84/228 (36%), Gaps = 27/228 (11%)
Query: 17 EKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEG-KEKPDQDAEGKAEEKEGEKDA 75
+KA+EK+ K E + + EP+A E +AK +E+ Q E E KE D
Sbjct: 155 QKAEEKEAKPESGQKADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDE 214
Query: 76 AAAKE-------EAPKAEPEKTEG----------AAEAKAEPPKAPEQEQAAPGPAAGGE 118
A E + KAEP++ +G A+AK E A E E +P +
Sbjct: 215 EAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQD 274
Query: 119 APKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSE 178
K E A S+ E P+ EG T+ D + + P +SE
Sbjct: 275 VEKEPEGGAGVIPSSPEEWPESPT-GEGHNLSTDG--------LGPDCVASGQTSPSASE 325
Query: 179 AAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVK 226
++PS S K + P P P A + + + K
Sbjct: 326 SSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPRGPRAQNRKAIVDK 373
Score = 56.2 bits (134), Expect = 2e-08
Identities = 57/210 (27%), Positives = 86/210 (40%), Gaps = 16/210 (7%)
Query: 17 EKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAA 76
E KE +K E +E T ++ E ++ EP EA+E KE + KAEEKE + ++
Sbjct: 111 ELKKEDGEKEETTVGSQEMTGRKEETKS--EPKEAEE-KESTLASEKQKAEEKEAKPESG 167
Query: 77 AAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPA 136
++A + +K E A + E K QE+ E + A A AES
Sbjct: 168 ---QKADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAV 224
Query: 137 AGEEPSKEEGEPKKTEAPAAPAAQE--TKSDGAPASDSKPGSSEAAPSSKETPAATEAPS 194
+E E EP E A +E K + A +++PGS PS ++ + P
Sbjct: 225 VEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGS----PSEEQEQDVEKEPE 280
Query: 195 STPKAQGPAASAEEPKPVEAPAANSDQTVT 224
G S+ E P E+P T
Sbjct: 281 G---GAGVIPSSPEEWP-ESPTGEGHNLST 306
Score = 53.1 bits (126), Expect = 2e-07
Identities = 58/231 (25%), Positives = 92/231 (39%), Gaps = 29/231 (12%)
Query: 6 SKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGK 65
+K G +N+ E K+ + A + + E E + + +DAE +
Sbjct: 52 TKGTAGKAINEGPPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAE 111
Query: 66 AEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQE-------QAAPGPAAGGE 118
++++GEK EE E T E K+EP +A E+E Q A A E
Sbjct: 112 LKKEDGEK------EETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPE 165
Query: 119 APKAAEA---------AAAPAESAAPAAGEEPSKEE---GEPKKTEAPAAPAAQETKS-- 164
+ + A+A A E A A+ EE + + EPK+ A+ K+
Sbjct: 166 SGQKADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVV 225
Query: 165 -DGAPASDSKP-GSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVE 213
D A A +P G EA +KE A E +A+ + S E+ + VE
Sbjct: 226 EDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVE 276
Score = 45.8 bits (107), Expect = 3e-05
Identities = 54/228 (23%), Positives = 91/228 (39%), Gaps = 42/228 (18%)
Query: 18 KAKEKDKKAEGAATEEEGT--PKESEPQAAAEPAEAKE-----------------GKEKP 58
+A+EK ++ EG +E+ T P P+ + A A+E GK++
Sbjct: 14 EAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGPPTESGKQEK 73
Query: 59 DQDAEGKAEEKEGEKDA-----------AAAKEEAPKAEPEKTEGAAE----AKAEPPKA 103
+G + E +GE + A KE+A +AE +K +G E E
Sbjct: 74 APAEDGMSAELQGEANGLDEVKVESQREAGGKEDA-EAELKKEDGEKEETTVGSQEMTGR 132
Query: 104 PEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETK 163
E+ ++ P A E+ A+E A + A P +G++ + + + P A +
Sbjct: 133 KEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPE------PKATVEE 186
Query: 164 SDGAPASDSKPGS-SEAAPSSKETPAATEAPSSTPKAQGPAASAEEPK 210
D AS + G E + KE EA + + KA + EPK
Sbjct: 187 EDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPK 234
Score = 42.7 bits (99), Expect = 3e-04
Identities = 41/170 (24%), Positives = 62/170 (36%), Gaps = 6/170 (3%)
Query: 54 GKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGP 113
G+ +A K E+KEG+ PE + G A A+ A + P P
Sbjct: 7 GESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGP-P 65
Query: 114 AAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSK 173
G+ KA AE A G + K E + + A E K + ++
Sbjct: 66 TESGKQEKAPAEDGMSAELQGEANGLDEVKVESQ--REAGGKEDAEAELKKEDGEKEETT 123
Query: 174 PGSSEAAPSSKET---PAATEAPSSTPKAQGPAASAEEPKPVEAPAANSD 220
GS E +ET P E ST ++ A +E KP A+++
Sbjct: 124 VGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADAN 173
Score = 33.5 bits (75), Expect = 0.15
Identities = 28/124 (22%), Positives = 50/124 (40%), Gaps = 11/124 (8%)
Query: 15 NDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKD 74
++E+ ++ +K+ EG A +P+E E PD A G+
Sbjct: 268 SEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGHNLSTDGLGPDCVASGQT-------- 319
Query: 75 AAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAA 134
+ +A E +P P+ + + + KAPE+ +AP G P+A A +
Sbjct: 320 SPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPRG---PRAQNRKAIVDKFGG 376
Query: 135 PAAG 138
A+G
Sbjct: 377 AASG 380
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.287 0.110 0.283
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,700,729
Number of Sequences: 37866
Number of extensions: 767228
Number of successful extensions: 24856
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1498
Number of HSP's successfully gapped in prelim test: 2083
Number of HSP's that attempted gapping in prelim test: 6242
Number of HSP's gapped (non-prelim): 12066
length of query: 227
length of database: 18,247,518
effective HSP length: 99
effective length of query: 128
effective length of database: 14,498,784
effective search space: 1855844352
effective search space used: 1855844352
T: 11
A: 40
X1: 17 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 45 (21.8 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.