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Search of human proteins with 30795121
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|30795121 F-box and WD repeat domain containing 8 isoform 2
[Homo sapiens]
(532 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|30795121 F-box and WD repeat domain containing 8 isoform 2 [H... 1090 0.0
gi|30795123 F-box and WD repeat domain containing 8 isoform 1 [H... 1040 0.0
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 89 1e-17
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 89 1e-17
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 89 1e-17
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 66 9e-11
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 66 9e-11
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 57 4e-08
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 57 4e-08
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 57 4e-08
gi|23199987 WD repeat domain 5B [Homo sapiens] 53 8e-07
gi|16554629 WD repeat domain 5 [Homo sapiens] 50 7e-06
gi|16554627 WD repeat domain 5 [Homo sapiens] 50 7e-06
gi|118402584 F-box and WD repeat domain containing 2 [Homo sapiens] 48 3e-05
gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens] 48 3e-05
gi|15812198 F-box only protein 2 [Homo sapiens] 48 3e-05
gi|21536371 telomerase-associated protein 1 [Homo sapiens] 46 7e-05
gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens] 45 1e-04
gi|26665869 WD repeat domain 51B [Homo sapiens] 45 2e-04
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 45 2e-04
gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens] 44 3e-04
gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens] 44 3e-04
gi|118150678 epithelial cell transforming sequence 2 oncogene-li... 44 4e-04
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 44 5e-04
gi|27312027 F-box only protein 16 [Homo sapiens] 44 5e-04
gi|66932902 SREBF chaperone protein [Homo sapiens] 43 6e-04
gi|55743075 angio-associated, migratory cell protein [Homo sapiens] 43 8e-04
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 43 8e-04
gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens] 42 0.001
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 41 0.003
>gi|30795121 F-box and WD repeat domain containing 8 isoform 2 [Homo
sapiens]
Length = 532
Score = 1090 bits (2819), Expect = 0.0
Identities = 532/532 (100%), Positives = 532/532 (100%)
Query: 1 MDDYSLDEFRRRWQEELAQAQAPKKRRRPEAAERRARRPENEMNDVPFFDIQLPYELAIN 60
MDDYSLDEFRRRWQEELAQAQAPKKRRRPEAAERRARRPENEMNDVPFFDIQLPYELAIN
Sbjct: 1 MDDYSLDEFRRRWQEELAQAQAPKKRRRPEAAERRARRPENEMNDVPFFDIQLPYELAIN 60
Query: 61 IFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSSISDYSCWKLIFQECRA 120
IFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSSISDYSCWKLIFQECRA
Sbjct: 61 IFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSSISDYSCWKLIFQECRA 120
Query: 121 KEHMLRTNWKNRKGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPF 180
KEHMLRTNWKNRKGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPF
Sbjct: 121 KEHMLRTNWKNRKGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPF 180
Query: 181 LESEDEEDEPGMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDARIQALA 240
LESEDEEDEPGMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDARIQALA
Sbjct: 181 LESEDEEDEPGMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDARIQALA 240
Query: 241 LSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVAVAAAGD 300
LSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVAVAAAGD
Sbjct: 241 LSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVAVAAAGD 300
Query: 301 LMYLLKAEDSARTLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLEAGRRLL 360
LMYLLKAEDSARTLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLEAGRRLL
Sbjct: 301 LMYLLKAEDSARTLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLEAGRRLL 360
Query: 361 KLGNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDW 420
KLGNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDW
Sbjct: 361 KLGNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDW 420
Query: 421 KIVSGGEEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSF 480
KIVSGGEEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSF
Sbjct: 421 KIVSGGEEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSF 480
Query: 481 TTHRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAMATHYYDLALAFPYNHV 532
TTHRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAMATHYYDLALAFPYNHV
Sbjct: 481 TTHRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAMATHYYDLALAFPYNHV 532
>gi|30795123 F-box and WD repeat domain containing 8 isoform 1 [Homo
sapiens]
Length = 598
Score = 1040 bits (2688), Expect = 0.0
Identities = 528/598 (88%), Positives = 529/598 (88%), Gaps = 66/598 (11%)
Query: 1 MDDYSLDEFRRRWQEELAQAQAPKKR----------RRPEA--------------AER-- 34
MDDYSLDEFRRRWQEELAQAQAPKKR RRPE A+R
Sbjct: 1 MDDYSLDEFRRRWQEELAQAQAPKKRRRPEAAERRARRPEVGSGRGEQASGDPALAQRLL 60
Query: 35 ---------RARRPE-------------------------------NEMNDVPFFDIQLP 54
RA R E NEMNDVPFFDIQLP
Sbjct: 61 EGAGRPPAARATRAEGQDVASRSRSPLAREGAGGGEQLVDQLIRDLNEMNDVPFFDIQLP 120
Query: 55 YELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSSISDYSCWKLI 114
YELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSSISDYSCWKLI
Sbjct: 121 YELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSSISDYSCWKLI 180
Query: 115 FQECRAKEHMLRTNWKNRKGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTW 174
FQECRAKEHMLRTNWKNRKGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTW
Sbjct: 181 FQECRAKEHMLRTNWKNRKGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTW 240
Query: 175 DYVAPFLESEDEEDEPGMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDA 234
DYVAPFLESEDEEDEPGMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDA
Sbjct: 241 DYVAPFLESEDEEDEPGMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDA 300
Query: 235 RIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVA 294
RIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVA
Sbjct: 301 RIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVA 360
Query: 295 VAAAGDLMYLLKAEDSARTLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLE 354
VAAAGDLMYLLKAEDSARTLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLE
Sbjct: 361 VAAAGDLMYLLKAEDSARTLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLE 420
Query: 355 AGRRLLKLGNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSA 414
AGRRLLKLGNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSA
Sbjct: 421 AGRRLLKLGNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSA 480
Query: 415 VQMDDWKIVSGGEEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRN 474
VQMDDWKIVSGGEEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRN
Sbjct: 481 VQMDDWKIVSGGEEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRN 540
Query: 475 ADLDSFTTHRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAMATHYYDLALAFPYNHV 532
ADLDSFTTHRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAMATHYYDLALAFPYNHV
Sbjct: 541 ADLDSFTTHRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAMATHYYDLALAFPYNHV 598
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 89.0 bits (219), Expect = 1e-17
Identities = 96/435 (22%), Positives = 181/435 (41%), Gaps = 56/435 (12%)
Query: 53 LPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQEG-----HLPDSSISD 107
LP ELA+ + +L+ K+L + AQ + W+++AED +LW C++EG H+ +
Sbjct: 166 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIK 225
Query: 108 ----YSCWKLIFQECRAKEHMLRTNWKNRKGAVSE---LEHVPDTVLCDVHSHDGVVIAG 160
+S WK + ++H + TNW R+G + L+ D V+ + +++G
Sbjct: 226 PGFIHSPWKSAY----IRQHRIDTNW--RRGELKSPKVLKGHDDHVITCLQFCGNRIVSG 279
Query: 161 YTSGDVRVWDTRTWDYVAPFLESEDEEDEPGMQPNVSFVRINSSLAVAAYEDGFLNIWDL 220
++VW T + + G V ++ ++ ++ D L +W+
Sbjct: 280 SDDNTLKVWSAVTGKCLRTLV---------GHTGGVWSSQMRDNIIISGSTDRTLKVWNA 330
Query: 221 RTGKYPVHRFEHDARIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQ 280
TG+ + H + ++ + L + + A V + + + VQ
Sbjct: 331 ETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQ 390
Query: 281 YLEIVPETRRYPVAVAAAGDLMYLLKAEDSARTL--LYAHGPPVTCLDVSANQVAFGVQG 338
Y + RR V+ A D M + ++ L L H V L V G
Sbjct: 391 Y-----DGRR---VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSL- 441
Query: 339 LGWVYEGSKILVYSLEAGRRLLKLGNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDLRS 398
+ I V+ +E G + L + + L D N++VSGN D V+I D+++
Sbjct: 442 ------DTSIRVWDVETGNCIHTLTGHQSLTSGMELKD---NILVSGNADSTVKIWDIKT 492
Query: 399 GNIALSL---SAHQLRVSAVQMDDWKIVSGGEEGLVSVWDYRMNQKLWEVY------SGH 449
G +L + HQ V+ +Q + +++ ++G V +WD + + + + SG
Sbjct: 493 GQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGG 552
Query: 450 PVQHISFSSHSLITA 464
V I S+ L+ A
Sbjct: 553 VVWRIRASNTKLVCA 567
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 89.0 bits (219), Expect = 1e-17
Identities = 96/435 (22%), Positives = 181/435 (41%), Gaps = 56/435 (12%)
Query: 53 LPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQEG-----HLPDSSISD 107
LP ELA+ + +L+ K+L + AQ + W+++AED +LW C++EG H+ +
Sbjct: 284 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIK 343
Query: 108 ----YSCWKLIFQECRAKEHMLRTNWKNRKGAVSE---LEHVPDTVLCDVHSHDGVVIAG 160
+S WK + ++H + TNW R+G + L+ D V+ + +++G
Sbjct: 344 PGFIHSPWKSAY----IRQHRIDTNW--RRGELKSPKVLKGHDDHVITCLQFCGNRIVSG 397
Query: 161 YTSGDVRVWDTRTWDYVAPFLESEDEEDEPGMQPNVSFVRINSSLAVAAYEDGFLNIWDL 220
++VW T + + G V ++ ++ ++ D L +W+
Sbjct: 398 SDDNTLKVWSAVTGKCLRTLV---------GHTGGVWSSQMRDNIIISGSTDRTLKVWNA 448
Query: 221 RTGKYPVHRFEHDARIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQ 280
TG+ + H + ++ + L + + A V + + + VQ
Sbjct: 449 ETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQ 508
Query: 281 YLEIVPETRRYPVAVAAAGDLMYLLKAEDSARTL--LYAHGPPVTCLDVSANQVAFGVQG 338
Y + RR V+ A D M + ++ L L H V L V G
Sbjct: 509 Y-----DGRR---VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSL- 559
Query: 339 LGWVYEGSKILVYSLEAGRRLLKLGNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDLRS 398
+ I V+ +E G + L + + L D N++VSGN D V+I D+++
Sbjct: 560 ------DTSIRVWDVETGNCIHTLTGHQSLTSGMELKD---NILVSGNADSTVKIWDIKT 610
Query: 399 GNIALSL---SAHQLRVSAVQMDDWKIVSGGEEGLVSVWDYRMNQKLWEVY------SGH 449
G +L + HQ V+ +Q + +++ ++G V +WD + + + + SG
Sbjct: 611 GQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGG 670
Query: 450 PVQHISFSSHSLITA 464
V I S+ L+ A
Sbjct: 671 VVWRIRASNTKLVCA 685
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 89.0 bits (219), Expect = 1e-17
Identities = 96/435 (22%), Positives = 181/435 (41%), Gaps = 56/435 (12%)
Query: 53 LPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQEG-----HLPDSSISD 107
LP ELA+ + +L+ K+L + AQ + W+++AED +LW C++EG H+ +
Sbjct: 204 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIK 263
Query: 108 ----YSCWKLIFQECRAKEHMLRTNWKNRKGAVSE---LEHVPDTVLCDVHSHDGVVIAG 160
+S WK + ++H + TNW R+G + L+ D V+ + +++G
Sbjct: 264 PGFIHSPWKSAY----IRQHRIDTNW--RRGELKSPKVLKGHDDHVITCLQFCGNRIVSG 317
Query: 161 YTSGDVRVWDTRTWDYVAPFLESEDEEDEPGMQPNVSFVRINSSLAVAAYEDGFLNIWDL 220
++VW T + + G V ++ ++ ++ D L +W+
Sbjct: 318 SDDNTLKVWSAVTGKCLRTLV---------GHTGGVWSSQMRDNIIISGSTDRTLKVWNA 368
Query: 221 RTGKYPVHRFEHDARIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQ 280
TG+ + H + ++ + L + + A V + + + VQ
Sbjct: 369 ETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQ 428
Query: 281 YLEIVPETRRYPVAVAAAGDLMYLLKAEDSARTL--LYAHGPPVTCLDVSANQVAFGVQG 338
Y + RR V+ A D M + ++ L L H V L V G
Sbjct: 429 Y-----DGRR---VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSL- 479
Query: 339 LGWVYEGSKILVYSLEAGRRLLKLGNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDLRS 398
+ I V+ +E G + L + + L D N++VSGN D V+I D+++
Sbjct: 480 ------DTSIRVWDVETGNCIHTLTGHQSLTSGMELKD---NILVSGNADSTVKIWDIKT 530
Query: 399 GNIALSL---SAHQLRVSAVQMDDWKIVSGGEEGLVSVWDYRMNQKLWEVY------SGH 449
G +L + HQ V+ +Q + +++ ++G V +WD + + + + SG
Sbjct: 531 GQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGG 590
Query: 450 PVQHISFSSHSLITA 464
V I S+ L+ A
Sbjct: 591 VVWRIRASNTKLVCA 605
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 65.9 bits (159), Expect = 9e-11
Identities = 76/404 (18%), Positives = 143/404 (35%), Gaps = 88/404 (21%)
Query: 57 LAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQ-------------------- 96
+A NI YLD K L V K W + D +LW +L ++
Sbjct: 156 IAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQY 215
Query: 97 --EGHLPDSSISDYSCWKLIFQECRAKEHMLRTNWKNRKGAVSELEHVPDT---VLCDVH 151
+ PD + S ++ ++ + + +NW+ + ++ + +T V C +
Sbjct: 216 LFKNKPPDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYC-LQ 274
Query: 152 SHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDEPGMQPNVSFVRINSSLAVAAYE 211
D +++G +++WD T E + G +V ++ + + +
Sbjct: 275 YDDQKIVSGLRDNTIKIWDKNT---------LECKRILTGHTGSVLCLQYDERVIITGSS 325
Query: 212 DGFLNIWDLRTGKYPVHRFEHDARIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAA 271
D + +WD+ TG+ H + L L ++ + T S W +A+
Sbjct: 326 DSTVRVWDVNTGEMLNTLIHHCEAV--LHLRFNNGMMVTCS-------KDRSIAVWDMAS 376
Query: 272 EFEVPKLVQYLEIVPETRRYPVAVAAAGDLMYLLKAEDSARTLLYAHGPPVTCLDVSANQ 331
++ + R +L H V +D
Sbjct: 377 PTDI----------------------------------TLRRVLVGHRAAVNVVDFDDKY 402
Query: 332 VAFGVQGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDFTCVNLSDSPPNLMVSGNMDGRV 391
+ V G I V++ + L R C+ D L+VSG+ D +
Sbjct: 403 I---VSASG----DRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD---RLVVSGSSDNTI 452
Query: 392 RIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGGEEGLVSVWD 435
R+ D+ G L H+ V ++ D+ +IVSG +G + VWD
Sbjct: 453 RLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWD 496
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 65.9 bits (159), Expect = 9e-11
Identities = 76/404 (18%), Positives = 143/404 (35%), Gaps = 88/404 (21%)
Query: 57 LAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQ-------------------- 96
+A NI YLD K L V K W + D +LW +L ++
Sbjct: 192 IAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQY 251
Query: 97 --EGHLPDSSISDYSCWKLIFQECRAKEHMLRTNWKNRKGAVSELEHVPDT---VLCDVH 151
+ PD + S ++ ++ + + +NW+ + ++ + +T V C +
Sbjct: 252 LFKNKPPDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYC-LQ 310
Query: 152 SHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDEPGMQPNVSFVRINSSLAVAAYE 211
D +++G +++WD T E + G +V ++ + + +
Sbjct: 311 YDDQKIVSGLRDNTIKIWDKNT---------LECKRILTGHTGSVLCLQYDERVIITGSS 361
Query: 212 DGFLNIWDLRTGKYPVHRFEHDARIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAA 271
D + +WD+ TG+ H + L L ++ + T S W +A+
Sbjct: 362 DSTVRVWDVNTGEMLNTLIHHCEAV--LHLRFNNGMMVTCS-------KDRSIAVWDMAS 412
Query: 272 EFEVPKLVQYLEIVPETRRYPVAVAAAGDLMYLLKAEDSARTLLYAHGPPVTCLDVSANQ 331
++ + R +L H V +D
Sbjct: 413 PTDI----------------------------------TLRRVLVGHRAAVNVVDFDDKY 438
Query: 332 VAFGVQGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDFTCVNLSDSPPNLMVSGNMDGRV 391
+ V G I V++ + L R C+ D L+VSG+ D +
Sbjct: 439 I---VSASG----DRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD---RLVVSGSSDNTI 488
Query: 392 RIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGGEEGLVSVWD 435
R+ D+ G L H+ V ++ D+ +IVSG +G + VWD
Sbjct: 489 RLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWD 532
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 57.0 bits (136), Expect = 4e-08
Identities = 77/420 (18%), Positives = 163/420 (38%), Gaps = 71/420 (16%)
Query: 57 LAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQ-----------------EGH 99
+A NI YLD + L V K W+ + + +LW +L ++ + +
Sbjct: 131 IAENILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQY 190
Query: 100 LPDSSISD---YSCWKLIFQECRAKEHMLRTNWKNRKGAVSELEHVPDT---VLCDVHSH 153
L + +D S ++ ++ + + +NW+ + + ++ + V C +
Sbjct: 191 LFKNRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYC-LQYD 249
Query: 154 DGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDEPGMQPNVSFVRINSSLAVAAYEDG 213
D +I+G +++WD + + + G +V ++ + + V D
Sbjct: 250 DEKIISGLRDNSIKIWDKTSLECLKVLT---------GHTGSVLCLQYDERVIVTGSSDS 300
Query: 214 FLNIWDLRTGKYPVHRFEHDARIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEF 273
+ +WD+ TG+ H+ + L S + V W +A+
Sbjct: 301 TVRVWDVNTGEVLNTLIHHNEAVLHLRFS---------NGLMVTCSKDRSIAVWDMASAT 351
Query: 274 EVPK---LVQY---LEIVPETRRYPVAVAAAGDLMYLLKAEDSARTL--LYAHGPPVTCL 325
++ LV + + +V +Y V+A+GD + + + + L H + CL
Sbjct: 352 DITLRRVLVGHRAAVNVVDFDDKY--IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACL 409
Query: 326 DVSANQVAFGVQGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDFTCVNLSDSPPNLMVSG 385
V G + I ++ +E G L L C+ + +VSG
Sbjct: 410 QYRDRLVVSGSSD-------NTIRLWDIECGACLRVLEGHEELVRCIRFDNKR---IVSG 459
Query: 386 NMDGRVRIHDLRSG--------NIAL-SLSAHQLRVSAVQMDDWKIVSGGEEGLVSVWDY 436
DG++++ DL++ + L +L H RV +Q D+++I+S + + +WD+
Sbjct: 460 AYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDF 519
Score = 41.2 bits (95), Expect = 0.002
Identities = 30/119 (25%), Positives = 52/119 (43%), Gaps = 5/119 (4%)
Query: 382 MVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGGEEGLVSVWDYRMNQK 441
++SG D ++I D S L+ H V +Q D+ IV+G + V VWD +
Sbjct: 253 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEV 312
Query: 442 L-WEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRR----HRGLIRAYEF 495
L ++ V H+ FS+ ++T + + + + T RR HR + +F
Sbjct: 313 LNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF 371
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 57.0 bits (136), Expect = 4e-08
Identities = 77/420 (18%), Positives = 163/420 (38%), Gaps = 71/420 (16%)
Query: 57 LAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQ-----------------EGH 99
+A NI YLD + L V K W+ + + +LW +L ++ + +
Sbjct: 97 IAENILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQY 156
Query: 100 LPDSSISD---YSCWKLIFQECRAKEHMLRTNWKNRKGAVSELEHVPDT---VLCDVHSH 153
L + +D S ++ ++ + + +NW+ + + ++ + V C +
Sbjct: 157 LFKNRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYC-LQYD 215
Query: 154 DGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDEPGMQPNVSFVRINSSLAVAAYEDG 213
D +I+G +++WD + + + G +V ++ + + V D
Sbjct: 216 DEKIISGLRDNSIKIWDKTSLECLKVLT---------GHTGSVLCLQYDERVIVTGSSDS 266
Query: 214 FLNIWDLRTGKYPVHRFEHDARIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEF 273
+ +WD+ TG+ H+ + L S + V W +A+
Sbjct: 267 TVRVWDVNTGEVLNTLIHHNEAVLHLRFS---------NGLMVTCSKDRSIAVWDMASAT 317
Query: 274 EVPK---LVQY---LEIVPETRRYPVAVAAAGDLMYLLKAEDSARTL--LYAHGPPVTCL 325
++ LV + + +V +Y V+A+GD + + + + L H + CL
Sbjct: 318 DITLRRVLVGHRAAVNVVDFDDKY--IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACL 375
Query: 326 DVSANQVAFGVQGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDFTCVNLSDSPPNLMVSG 385
V G + I ++ +E G L L C+ + +VSG
Sbjct: 376 QYRDRLVVSGSSD-------NTIRLWDIECGACLRVLEGHEELVRCIRFDNKR---IVSG 425
Query: 386 NMDGRVRIHDLRSG--------NIAL-SLSAHQLRVSAVQMDDWKIVSGGEEGLVSVWDY 436
DG++++ DL++ + L +L H RV +Q D+++I+S + + +WD+
Sbjct: 426 AYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDF 485
Score = 41.2 bits (95), Expect = 0.002
Identities = 30/119 (25%), Positives = 52/119 (43%), Gaps = 5/119 (4%)
Query: 382 MVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGGEEGLVSVWDYRMNQK 441
++SG D ++I D S L+ H V +Q D+ IV+G + V VWD +
Sbjct: 219 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEV 278
Query: 442 L-WEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRR----HRGLIRAYEF 495
L ++ V H+ FS+ ++T + + + + T RR HR + +F
Sbjct: 279 LNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF 337
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 57.0 bits (136), Expect = 4e-08
Identities = 77/420 (18%), Positives = 163/420 (38%), Gaps = 71/420 (16%)
Query: 57 LAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQ-----------------EGH 99
+A NI YLD + L V K W+ + + +LW +L ++ + +
Sbjct: 118 IAENILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQY 177
Query: 100 LPDSSISD---YSCWKLIFQECRAKEHMLRTNWKNRKGAVSELEHVPDT---VLCDVHSH 153
L + +D S ++ ++ + + +NW+ + + ++ + V C +
Sbjct: 178 LFKNRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYC-LQYD 236
Query: 154 DGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDEPGMQPNVSFVRINSSLAVAAYEDG 213
D +I+G +++WD + + + G +V ++ + + V D
Sbjct: 237 DEKIISGLRDNSIKIWDKTSLECLKVLT---------GHTGSVLCLQYDERVIVTGSSDS 287
Query: 214 FLNIWDLRTGKYPVHRFEHDARIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEF 273
+ +WD+ TG+ H+ + L S + V W +A+
Sbjct: 288 TVRVWDVNTGEVLNTLIHHNEAVLHLRFS---------NGLMVTCSKDRSIAVWDMASAT 338
Query: 274 EVPK---LVQY---LEIVPETRRYPVAVAAAGDLMYLLKAEDSARTL--LYAHGPPVTCL 325
++ LV + + +V +Y V+A+GD + + + + L H + CL
Sbjct: 339 DITLRRVLVGHRAAVNVVDFDDKY--IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACL 396
Query: 326 DVSANQVAFGVQGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDFTCVNLSDSPPNLMVSG 385
V G + I ++ +E G L L C+ + +VSG
Sbjct: 397 QYRDRLVVSGSSD-------NTIRLWDIECGACLRVLEGHEELVRCIRFDNKR---IVSG 446
Query: 386 NMDGRVRIHDLRSG--------NIAL-SLSAHQLRVSAVQMDDWKIVSGGEEGLVSVWDY 436
DG++++ DL++ + L +L H RV +Q D+++I+S + + +WD+
Sbjct: 447 AYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDF 506
Score = 41.2 bits (95), Expect = 0.002
Identities = 30/119 (25%), Positives = 52/119 (43%), Gaps = 5/119 (4%)
Query: 382 MVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGGEEGLVSVWDYRMNQK 441
++SG D ++I D S L+ H V +Q D+ IV+G + V VWD +
Sbjct: 240 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEV 299
Query: 442 L-WEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRR----HRGLIRAYEF 495
L ++ V H+ FS+ ++T + + + + T RR HR + +F
Sbjct: 300 LNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF 358
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 52.8 bits (125), Expect = 8e-07
Identities = 46/176 (26%), Positives = 81/176 (46%), Gaps = 20/176 (11%)
Query: 336 VQGLGWVYEGSKIL---------VYSLEAGRRLLKLGNVLRDFTCVNLSDSPPNLMVSGN 386
+ + W + S+++ ++ + +G+ L L C N + P NL++SG+
Sbjct: 86 ISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNP-PSNLIISGS 144
Query: 387 MDGRVRIHDLRSGNIALSLSAHQLRVSAVQMD--DWKIVSGGEEGLVSVWDYRMNQKLWE 444
D V+I ++++G +LSAH VSAV + IVSG +GL +WD Q L
Sbjct: 145 FDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKT 204
Query: 445 VY--SGHPVQHISFSSHS--LITANVPYQTVM----RNADLDSFTTHRRHRGLIRA 492
+ PV + FS + ++TA + + R L ++T H+ + I A
Sbjct: 205 LVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFA 260
Score = 31.6 bits (70), Expect = 1.9
Identities = 21/79 (26%), Positives = 36/79 (45%), Gaps = 11/79 (13%)
Query: 148 CDVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDEPGMQPNVSFVRIN--SSL 205
C+ + ++I+G V++W+ +T L++ +P VS V N SL
Sbjct: 131 CNFNPPSNLIISGSFDETVKIWEVKT----GKCLKTLSAHSDP-----VSAVHFNCSGSL 181
Query: 206 AVAAYEDGFLNIWDLRTGK 224
V+ DG IWD +G+
Sbjct: 182 IVSGSYDGLCRIWDAASGQ 200
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 49.7 bits (117), Expect = 7e-06
Identities = 43/153 (28%), Positives = 66/153 (43%), Gaps = 11/153 (7%)
Query: 350 VYSLEAGRRLLKLGNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQ 409
++ + +G+ L L C N + NL+VSG+ D VRI D+++G +L AH
Sbjct: 113 IWDVSSGKCLKTLKGHSNYVFCCNFNPQS-NLIVSGSFDESVRIWDVKTGKCLKTLPAHS 171
Query: 410 LRVSAVQM--DDWKIVSGGEEGLVSVWDYRMNQKLWEVY--SGHPVQHISFSSHSLITAN 465
VSAV D IVS +GL +WD Q L + PV + FS +
Sbjct: 172 DPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILA 231
Query: 466 VPYQTVMRNAD------LDSFTTHRRHRGLIRA 492
++ D L ++T H+ + I A
Sbjct: 232 ATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFA 264
Score = 35.0 bits (79), Expect = 0.17
Identities = 21/79 (26%), Positives = 34/79 (43%), Gaps = 11/79 (13%)
Query: 148 CDVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDEPGMQPNVSFVRIN--SSL 205
C+ + ++++G VR+WD +T + P VS V N SL
Sbjct: 135 CNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL---------PAHSDPVSAVHFNRDGSL 185
Query: 206 AVAAYEDGFLNIWDLRTGK 224
V++ DG IWD +G+
Sbjct: 186 IVSSSYDGLCRIWDTASGQ 204
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 49.7 bits (117), Expect = 7e-06
Identities = 43/153 (28%), Positives = 66/153 (43%), Gaps = 11/153 (7%)
Query: 350 VYSLEAGRRLLKLGNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQ 409
++ + +G+ L L C N + NL+VSG+ D VRI D+++G +L AH
Sbjct: 113 IWDVSSGKCLKTLKGHSNYVFCCNFNPQS-NLIVSGSFDESVRIWDVKTGKCLKTLPAHS 171
Query: 410 LRVSAVQM--DDWKIVSGGEEGLVSVWDYRMNQKLWEVY--SGHPVQHISFSSHSLITAN 465
VSAV D IVS +GL +WD Q L + PV + FS +
Sbjct: 172 DPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILA 231
Query: 466 VPYQTVMRNAD------LDSFTTHRRHRGLIRA 492
++ D L ++T H+ + I A
Sbjct: 232 ATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFA 264
Score = 35.0 bits (79), Expect = 0.17
Identities = 21/79 (26%), Positives = 34/79 (43%), Gaps = 11/79 (13%)
Query: 148 CDVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDEPGMQPNVSFVRIN--SSL 205
C+ + ++++G VR+WD +T + P VS V N SL
Sbjct: 135 CNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL---------PAHSDPVSAVHFNRDGSL 185
Query: 206 AVAAYEDGFLNIWDLRTGK 224
V++ DG IWD +G+
Sbjct: 186 IVSSSYDGLCRIWDTASGQ 204
>gi|118402584 F-box and WD repeat domain containing 2 [Homo sapiens]
Length = 454
Score = 47.8 bits (112), Expect = 3e-05
Identities = 57/279 (20%), Positives = 112/279 (40%), Gaps = 33/279 (11%)
Query: 53 LPYELAINIFQYLDRKELGRCAQVSKTW-KVIAEDEVLWYRLCQQEGHLPDSSISDYSCW 111
LP EL+ + ++LD + L C VSK W KVI+ +W C+ G D S+ D W
Sbjct: 60 LPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTACKNLGWQIDDSVQDALHW 119
Query: 112 KLIFQECRAKEHMLRTNWKNRKGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDT 171
K ++ + + L + ++ + H + ++ DG++ G ++WD
Sbjct: 120 KKVYLKAILRMKQLEDHEAFETSSL--IGH--SARVYALYYKDGLLCTGSDDLSAKLWDV 175
Query: 172 RTWDYVAPFLESEDEEDEPGMQPNV-SFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRF 230
T V G+Q + + V+ + V D + W+ +G H
Sbjct: 176 STGQCVY------------GIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFR 223
Query: 231 EHDARIQALALSQD-DATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLE----IV 285
H + ++ + + D V+ ++ F V + W ++A + L + E +V
Sbjct: 224 GHTGAVFSVDYNDELDILVSGSADFTVKV--------WALSAGTCLNTLTGHTEWVTKVV 275
Query: 286 PETRRYPVAVAAAGDLMYLLKAEDSARTLLYAHGPPVTC 324
+ + + + GD Y+L + D ++ G + C
Sbjct: 276 LQKCKVKSLLHSPGD--YILLSADKYEIKIWPIGREINC 312
Score = 32.7 bits (73), Expect = 0.85
Identities = 22/88 (25%), Positives = 41/88 (46%), Gaps = 13/88 (14%)
Query: 381 LMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGGEEGLVSVWDYRMNQ 440
L+ +G+ D ++ D+ +G + H +AV+ D+ K+V+G + V+ W++
Sbjct: 160 LLCTGSDDLSAKLWDVSTGQCVYGIQTHTC--AAVKFDEQKLVTGSFDNTVACWEWS--- 214
Query: 441 KLWEVYSGHPVQHISFSSHSLITANVPY 468
SG QH F H+ +V Y
Sbjct: 215 ------SGARTQH--FRGHTGAVFSVDY 234
>gi|16306582 F-box and leucine-rich repeat protein 2 [Homo
sapiens]
Length = 423
Score = 47.8 bits (112), Expect = 3e-05
Identities = 22/50 (44%), Positives = 30/50 (60%)
Query: 44 NDVPFFDIQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRL 93
ND + +LP EL + IF +LD L RCAQ+SK W ++A D W R+
Sbjct: 6 NDEGLINKKLPKELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRI 55
>gi|15812198 F-box only protein 2 [Homo sapiens]
Length = 296
Score = 47.8 bits (112), Expect = 3e-05
Identities = 30/119 (25%), Positives = 53/119 (44%), Gaps = 8/119 (6%)
Query: 15 EELAQAQAPKKRRRPEAAERRARRPENEMND-----VPFFDIQLPYELAINIFQYLDRKE 69
E + Q + +PE A RPE++ + + D +LP L + + L E
Sbjct: 8 ESVGQPEEASPEEQPEEASAEEERPEDQQEEEAAAAAAYLD-ELPEPLLLRVLAALPAAE 66
Query: 70 LGR-CAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSSI-SDYSCWKLIFQECRAKEHMLR 126
L + C V WK + + LW CQQEG +P+ + + W+ + + + ++LR
Sbjct: 67 LVQACRLVCLRWKELVDGAPLWLLKCQQEGLVPEGGVEEERDHWQQFYFLSKRRRNLLR 125
>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
Length = 2627
Score = 46.2 bits (108), Expect = 7e-05
Identities = 89/394 (22%), Positives = 138/394 (35%), Gaps = 70/394 (17%)
Query: 160 GYTSGDVRVWDTRTWDYVAPFLESEDEEDEPGMQPNVSFVRINSSLAVAAYEDGFLNIWD 219
G +G V + D RTW E++ G + + ++ DG L +WD
Sbjct: 1694 GTANGTVYLLDLRTWQ--------EEKSVVSGCDGISACLFLSDDTLFLTAFDGLLELWD 1745
Query: 220 LRTGKYPVHRFEHDARIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLV 279
L+ G + H +I LS D +AT + L G Q+A + PK +
Sbjct: 1746 LQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRG--QLAFQHTYPKSL 1803
Query: 280 QYLEIVPETRRYPVAVAAAGDLMYLLKAEDSARTLLYAHGPPVTCLDVSANQVAFGVQGL 339
+ PE + A + + + L G P + A V GV +
Sbjct: 1804 NCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDL----GAPGASIRTLAFNVPGGVVAV 1859
Query: 340 G--------WVY--------------------------------EGSKILVYSLEAGRRL 359
G W + E K+ V+S GR
Sbjct: 1860 GRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPR 1919
Query: 360 LKLGNV-LRDFTCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMD 418
LG++ L V LS + V DG +RI+ + SG+ A + VSA+
Sbjct: 1920 GHLGSLSLSPALSVALSPDGDRVAVGYRADG-IRIYKISSGSQGAQGQALDVAVSALAWL 1978
Query: 419 DWKI-VSGGEEGLVSVWDYR--MNQKLWEVYS-GHPVQHISFSSHSLITANV-------P 467
K+ VSG E+G + W + Q LW + PV ++ S L +A+ P
Sbjct: 1979 SPKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWP 2038
Query: 468 YQTVMRNADLDSF---TTHRRHRGLIRAYEFAVD 498
Q + R + F T R H G + F+ D
Sbjct: 2039 RQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTD 2072
Score = 45.1 bits (105), Expect = 2e-04
Identities = 43/140 (30%), Positives = 59/140 (42%), Gaps = 18/140 (12%)
Query: 306 KAED-SARTLLYAHGPPVTCLDVSANQVAFGVQG-----LGWVYEGSK--ILVYSLEAGR 357
KAED T L H PV+C S + + G L W K +L++S A
Sbjct: 2047 KAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACH 2106
Query: 358 RLLKLGNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQM 417
R G C D NL++S + DG V + D SG HQ VSAV
Sbjct: 2107 RDWVTG-------CAWTKD---NLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAA 2156
Query: 418 DDWKIVSGGEEGLVSVWDYR 437
+ +VS +G + VWD++
Sbjct: 2157 VEEHVVSVSRDGTLKVWDHQ 2176
Score = 30.0 bits (66), Expect = 5.5
Identities = 62/260 (23%), Positives = 101/260 (38%), Gaps = 42/260 (16%)
Query: 197 SFVRINSSLAVAAYEDGFLNIWDLRTGKYPV--HRFE--HDARIQALALSQDDATVATAS 252
SF SLA D L WD+RT K PV H F H + A ++D+ ++ +S
Sbjct: 2068 SFSTDGGSLATGG-RDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSS 2126
Query: 253 AFDVVMLSPNEEGYWQIAAEFEVPKLVQYL------EIVPETRRYPVAVAAAGDLMYLLK 306
V + P E G +L Q+L V + V+V+ G L +
Sbjct: 2127 DGSVGLWDP-ESG----------QRLGQFLGHQSAVSAVAAVEEHVVSVSRDGTLK-VWD 2174
Query: 307 AEDSARTLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYS--LEAGRRLLKLGN 364
+ T + AH P++ + A G GS++LV + L+ RL
Sbjct: 2175 HQGVELTSIPAHSGPISHCAAAMEPRAAG-------QPGSELLVVTVGLDGATRLWHPLL 2227
Query: 365 VLRDFTCVNLS--------DSPPNLMVSGNMDGRVRIHDL--RSGNIALSLSAHQLRVSA 414
V + T + S LM++ + DG VR+ + + + + S+ + A
Sbjct: 2228 VCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVA 2287
Query: 415 VQMDDWKIVSGGEEGLVSVW 434
D VSG + G + +W
Sbjct: 2288 WAPDGSMAVSGNQAGELILW 2307
Score = 30.0 bits (66), Expect = 5.5
Identities = 19/66 (28%), Positives = 28/66 (42%), Gaps = 9/66 (13%)
Query: 154 DGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDEPGMQPNVSFVRINSSLAVAAYEDG 213
D ++I+ + G V +WD + + FL G Q VS V V+ DG
Sbjct: 2118 DNLLISCSSDGSVGLWDPESGQRLGQFL---------GHQSAVSAVAAVEEHVVSVSRDG 2168
Query: 214 FLNIWD 219
L +WD
Sbjct: 2169 TLKVWD 2174
>gi|27734755 F-box and leucine-rich repeat protein 20 [Homo
sapiens]
Length = 436
Score = 45.4 bits (106), Expect = 1e-04
Identities = 22/50 (44%), Positives = 30/50 (60%)
Query: 44 NDVPFFDIQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRL 93
+D + +LP EL + IF +LD L RCAQVS+ W V+A D W R+
Sbjct: 19 SDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRI 68
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 45.1 bits (105), Expect = 2e-04
Identities = 68/245 (27%), Positives = 100/245 (40%), Gaps = 25/245 (10%)
Query: 232 HDARIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRY 291
H A I +L LS + +ATAS +ML W + V + ++V +
Sbjct: 17 HKAAITSLDLSPNGKQLATASWDTFLML-------WNFKPHARAYRYVGHKDVVTSVQFS 69
Query: 292 P---VAVAAAGDLMYLLKAEDSARTL--LYAHGPPVTCLDVSANQVAFGVQGLGWVYEGS 346
P + +A+ D L D AH PV +D SA+ Q L E
Sbjct: 70 PHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADG-----QFLATASEDK 124
Query: 347 KILVYSLEAGRRLLKLGNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLS 406
I V+S+ R L L C S L+VS + D ++I D + + S
Sbjct: 125 SIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDG-RLIVSCSEDKTIKIWDTTNKQCVNNFS 183
Query: 407 AHQLRVSAVQMDDWK--IVSGGEEGLVSVWDYRMNQKL--WEVYSGHPVQHISF--SSHS 460
+ V + I S G + V VWD R+N+ L ++V+SG V ISF S +
Sbjct: 184 DSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSG-GVNCISFHPSGNY 242
Query: 461 LITAN 465
LITA+
Sbjct: 243 LITAS 247
Score = 32.0 bits (71), Expect = 1.4
Identities = 27/109 (24%), Positives = 42/109 (38%), Gaps = 8/109 (7%)
Query: 146 VLCDVHSHDGVVIAGYTSGD-VRVWDTRTWDYVAPFLESEDEEDEPGMQPNVSFVRINSS 204
V C S DG +I + +++WDT V F D G V F +
Sbjct: 147 VRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNF------SDSVGFANFVDFNPSGTC 200
Query: 205 LAVAAYEDGFLNIWDLRTGKYPVHRFEHDARIQALALSQDDATVATASA 253
+A A D + +WD+R K H H + ++ + TAS+
Sbjct: 201 IASAG-SDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASS 248
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 44.7 bits (104), Expect = 2e-04
Identities = 39/142 (27%), Positives = 62/142 (43%), Gaps = 6/142 (4%)
Query: 348 ILVYSLEAGRRLLKLGNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSA 407
+ V+ E G R+ +L + P L+ +G+ DG V++ D+R A+
Sbjct: 133 VAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRK-KAAIQTFQ 191
Query: 408 HQLRVSAVQMDDW--KIVSGGEEGLVSVWDYRMNQKLWEVYSGH--PVQHISFSSHSLIT 463
+ +V AV +D +I+SGG + + VWD R N KL GH V +S SS
Sbjct: 192 NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQN-KLTYTMRGHADSVTGLSLSSEGSYL 250
Query: 464 ANVPYQTVMRNADLDSFTTHRR 485
+ +R D+ F R
Sbjct: 251 LSNAMDNTVRVWDVRPFAPKER 272
Score = 29.3 bits (64), Expect = 9.4
Identities = 27/119 (22%), Positives = 47/119 (39%), Gaps = 28/119 (23%)
Query: 130 KNRKGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDE 189
K GAV EL + D ++ + T V VWD+ T + V
Sbjct: 106 KGHSGAVMELHYNTD---------GSMLFSASTDKTVAVWDSETGERVKR---------- 146
Query: 190 PGMQPNVSFV------RINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDARIQALALS 242
++ + SFV R L +DG + +WD+R K + F++ ++ A+ +
Sbjct: 147 --LKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRK-KAAIQTFQNTYQVLAVTFN 202
>gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens]
Length = 1051
Score = 44.3 bits (103), Expect = 3e-04
Identities = 34/102 (33%), Positives = 51/102 (50%), Gaps = 5/102 (4%)
Query: 348 ILVYSLEAGRRLLKLGNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSA 407
I + L++G G TC++L N +VSG D +V++ D+ +G L
Sbjct: 477 IRYWDLKSGVCTRIFGGHQGTITCMDLCK---NRLVSGGRDCQVKVWDVDTGK-CLKTFR 532
Query: 408 HQLRVSAVQMDDWKIVSGGEEGLVSVWDYRMNQKLWEVYSGH 449
H+ + A +++D IVS E GLV VW M Q L + SGH
Sbjct: 533 HKDPILATRINDTYIVSSCERGLVKVWHIAMAQ-LVKTLSGH 573
Score = 41.6 bits (96), Expect = 0.002
Identities = 27/117 (23%), Positives = 53/117 (45%), Gaps = 11/117 (9%)
Query: 318 HGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDFTCVNLSDS 377
H +TC+D+ N++ G + ++ V+ ++ G+ LK ++D+
Sbjct: 494 HQGTITCMDLCKNRLVSGGRDC-------QVKVWDVDTGK-CLKTFRHKDPILATRINDT 545
Query: 378 PPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGGEEGLVSVW 434
+VS G V++ + + +LS H+ V + D W ++SG +GLV W
Sbjct: 546 ---YIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAW 599
Score = 40.0 bits (92), Expect = 0.005
Identities = 19/56 (33%), Positives = 31/56 (55%)
Query: 380 NLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGGEEGLVSVWD 435
N ++SG+ D +R DL+SG HQ ++ + + ++VSGG + V VWD
Sbjct: 466 NFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWD 521
Score = 31.6 bits (70), Expect = 1.9
Identities = 14/33 (42%), Positives = 20/33 (60%)
Query: 53 LPYELAINIFQYLDRKELGRCAQVSKTWKVIAE 85
LP L+ I + LDR L +CA VS+ W +A+
Sbjct: 281 LPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQ 313
>gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens]
Length = 752
Score = 44.3 bits (103), Expect = 3e-04
Identities = 34/102 (33%), Positives = 51/102 (50%), Gaps = 5/102 (4%)
Query: 348 ILVYSLEAGRRLLKLGNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSA 407
I + L++G G TC++L N +VSG D +V++ D+ +G L
Sbjct: 477 IRYWDLKSGVCTRIFGGHQGTITCMDLCK---NRLVSGGRDCQVKVWDVDTGK-CLKTFR 532
Query: 408 HQLRVSAVQMDDWKIVSGGEEGLVSVWDYRMNQKLWEVYSGH 449
H+ + A +++D IVS E GLV VW M Q L + SGH
Sbjct: 533 HKDPILATRINDTYIVSSCERGLVKVWHIAMAQ-LVKTLSGH 573
Score = 41.6 bits (96), Expect = 0.002
Identities = 27/117 (23%), Positives = 53/117 (45%), Gaps = 11/117 (9%)
Query: 318 HGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDFTCVNLSDS 377
H +TC+D+ N++ G + ++ V+ ++ G+ LK ++D+
Sbjct: 494 HQGTITCMDLCKNRLVSGGRDC-------QVKVWDVDTGK-CLKTFRHKDPILATRINDT 545
Query: 378 PPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGGEEGLVSVW 434
+VS G V++ + + +LS H+ V + D W ++SG +GLV W
Sbjct: 546 ---YIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAW 599
Score = 40.0 bits (92), Expect = 0.005
Identities = 19/56 (33%), Positives = 31/56 (55%)
Query: 380 NLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGGEEGLVSVWD 435
N ++SG+ D +R DL+SG HQ ++ + + ++VSGG + V VWD
Sbjct: 466 NFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWD 521
Score = 31.6 bits (70), Expect = 1.9
Identities = 14/33 (42%), Positives = 20/33 (60%)
Query: 53 LPYELAINIFQYLDRKELGRCAQVSKTWKVIAE 85
LP L+ I + LDR L +CA VS+ W +A+
Sbjct: 281 LPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQ 313
>gi|118150678 epithelial cell transforming sequence 2 oncogene-like
[Homo sapiens]
Length = 904
Score = 43.9 bits (102), Expect = 4e-04
Identities = 25/72 (34%), Positives = 37/72 (51%), Gaps = 2/72 (2%)
Query: 49 FDIQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQEG-HLP-DSSIS 106
F LP +++ IF +L K+L AQVS WK + E + LW C + G LP + +
Sbjct: 77 FSTVLPRFISLYIFSFLSPKDLCAAAQVSWPWKFLTEQDCLWMPKCVKFGWFLPYTPTDN 136
Query: 107 DYSCWKLIFQEC 118
+Y WK + C
Sbjct: 137 EYGAWKRHYIAC 148
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 43.5 bits (101), Expect = 5e-04
Identities = 37/148 (25%), Positives = 69/148 (46%), Gaps = 11/148 (7%)
Query: 348 ILVYSLEAGRRLLKLGNVLRDFTCVNLSDSPPNLMVS-GNMDGRVRIHDLRSGNIALSLS 406
+ ++ L G ++L L + ++ TC L SP L ++ G DG +RI L SG ++ +
Sbjct: 47 VFIWDLRKGEKILILQGLKQEVTC--LCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFN 104
Query: 407 AHQLRVSAVQMDD--WKIVSGGEEGLVSVWDYRMNQKLWEVYSGH--PVQHISFSSHSLI 462
H+ ++ ++ D ++ SG ++ + VWD L+ + GH + F +
Sbjct: 105 GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRL-KGHKDAITQALFLREKNL 163
Query: 463 TANVPYQTVMRNADLDS---FTTHRRHR 487
T+++ DLD+ F T HR
Sbjct: 164 LVTSGKDTMVKWWDLDTQHCFKTMVGHR 191
Score = 37.0 bits (84), Expect = 0.045
Identities = 18/59 (30%), Positives = 33/59 (55%), Gaps = 2/59 (3%)
Query: 382 MVSGNMDGRVRIHDLRSGNIALSLSAHQ--LRVSAVQMDDWKIVSGGEEGLVSVWDYRM 438
+V G G+++++DL SGN+ ++ AH L ++ D V+GG + V WD+ +
Sbjct: 469 VVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFEL 527
Score = 30.0 bits (66), Expect = 5.5
Identities = 36/158 (22%), Positives = 63/158 (39%), Gaps = 17/158 (10%)
Query: 150 VHSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDEPGMQPNVSFVRI-------- 201
+ +HDG + + S D R + T D F + E +DE Q +S +
Sbjct: 492 IDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDED 551
Query: 202 --------NSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDARIQALALSQDDATVATASA 253
N L + D + I+ + T K+ + + H + + +S D A +AT SA
Sbjct: 552 VLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSA 611
Query: 254 FDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRY 291
V + + G + F V YL+ VP++ +
Sbjct: 612 DRNVKIWGLDFGDCH-KSLFAHDDSVMYLQFVPKSHLF 648
>gi|27312027 F-box only protein 16 [Homo sapiens]
Length = 292
Score = 43.5 bits (101), Expect = 5e-04
Identities = 21/46 (45%), Positives = 28/46 (60%)
Query: 49 FDIQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLC 94
F +LP L++ IF +LD + L RCAQV WK +AE + LW C
Sbjct: 88 FTTKLPRVLSLYIFSFLDPRSLCRCAQVCWHWKNLAELDQLWMLKC 133
>gi|66932902 SREBF chaperone protein [Homo sapiens]
Length = 1279
Score = 43.1 bits (100), Expect = 6e-04
Identities = 32/133 (24%), Positives = 60/133 (45%), Gaps = 9/133 (6%)
Query: 313 TLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDFTCV 372
T+ AH P+T L +A ++ G Q + V+ LE L L T V
Sbjct: 1073 TVPCAHQKPITALKAAAGRLVTGSQD-------HTLRVFRLEDSCCLFTLQGHSGAITTV 1125
Query: 373 NLSDSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGGEEGLVS 432
+ + ++ SG DG + + D+ +G+ + AH+ V+++ ++S G + L+S
Sbjct: 1126 YIDQTM--VLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLIS 1183
Query: 433 VWDYRMNQKLWEV 445
+WD K + +
Sbjct: 1184 IWDRSTGIKFYSI 1196
Score = 36.2 bits (82), Expect = 0.077
Identities = 16/67 (23%), Positives = 35/67 (52%), Gaps = 1/67 (1%)
Query: 382 MVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIV-SGGEEGLVSVWDYRMNQ 440
+V+G+ D +R+ L +L H ++ V +D ++ SGG++G + +WD
Sbjct: 1092 LVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDVLTGS 1151
Query: 441 KLWEVYS 447
++ V++
Sbjct: 1152 RVSHVFA 1158
>gi|55743075 angio-associated, migratory cell protein [Homo sapiens]
Length = 434
Score = 42.7 bits (99), Expect = 8e-04
Identities = 38/146 (26%), Positives = 55/146 (37%), Gaps = 38/146 (26%)
Query: 144 DTVLCDVHSHDGVVIA-GYTSGDVRVWDTRT----------------WDYVAPFLESEDE 186
D+V C SHD ++A G SG ++VW T W AP L +
Sbjct: 135 DSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSFEAGDLEWMEWHPRAPVLLAGTA 194
Query: 187 EDE----------------PGMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRF 230
+ P V + AV YEDG + IWDL+ G P+H
Sbjct: 195 DGNTWMWKVPNGDCKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGS-PIHVL 253
Query: 231 E----HDARIQALALSQDDATVATAS 252
+ H + +A +QD + + T S
Sbjct: 254 KGTEGHQGPLTCVAANQDGSLILTGS 279
Score = 38.1 bits (87), Expect = 0.020
Identities = 28/113 (24%), Positives = 49/113 (43%), Gaps = 5/113 (4%)
Query: 340 GWVYEGSKILVYSLEAGRRLLKLGNVLRDFT--CVNLSDSPPNLMVSGNMDGRVRIHDLR 397
GWV E + +V S+E G ++ L + CV+L L V+G D + + L
Sbjct: 64 GWVLEPQEGVVGSME-GPDDSEVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLS 122
Query: 398 SGNIALSLSAHQLRVSAVQM--DDWKIVSGGEEGLVSVWDYRMNQKLWEVYSG 448
G + + H+ V+ D + +G GL+ VW +++W +G
Sbjct: 123 DGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSFEAG 175
Score = 34.7 bits (78), Expect = 0.22
Identities = 17/41 (41%), Positives = 22/41 (53%)
Query: 212 DGFLNIWDLRTGKYPVHRFEHDARIQALALSQDDATVATAS 252
DG + +WD RTG+ H A I ALS+D + V T S
Sbjct: 379 DGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTS 419
Score = 30.4 bits (67), Expect = 4.2
Identities = 44/209 (21%), Positives = 80/209 (38%), Gaps = 28/209 (13%)
Query: 203 SSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDARIQALALSQDDATVATASAFDVVMLSPN 262
++LAV ED +W L G+ H + S D VAT ++ +
Sbjct: 104 NTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKV--- 160
Query: 263 EEGYWQIAAEFEVPKL----VQYLEIVPETRRYPVAVAAAGD-LMYLLKAEDSARTLLYA 317
WQ+ + EV ++++E P R PV +A D ++ K +
Sbjct: 161 ----WQVDTKEEVWSFEAGDLEWMEWHP---RAPVLLAGTADGNTWMWKVPNGDCKTFQG 213
Query: 318 HGPPVTCLDV--SANQVAFGVQGLGWVYEGSKILVYSLEAGRRLLKLGNV---LRDFTCV 372
P TC V + G YE I ++ L+ G + L TCV
Sbjct: 214 PNCPATCGRVLPDGKRAVVG-------YEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCV 266
Query: 373 NLSDSPPNLMVSGNMDGRVRIHDLRSGNI 401
++ +L+++G++D + ++ +G +
Sbjct: 267 -AANQDGSLILTGSVDCQAKLVSATTGKV 294
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 42.7 bits (99), Expect = 8e-04
Identities = 65/285 (22%), Positives = 108/285 (37%), Gaps = 27/285 (9%)
Query: 157 VIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDEPGMQPNVSFVRI-NSSLAVAAYEDGFL 215
V + G VR+WDT E G +V+ +R L +A +D +
Sbjct: 219 VASSSKDGSVRIWDTTA---------GRCERILTGHTQSVTCLRWGGDGLLYSASQDRTI 269
Query: 216 NIWDLRTGKYPVHRFEHDARIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEV 275
+W G H + +ALS D A AF+ S N + E +
Sbjct: 270 KVWRAHDGVLCRTLQGHGHWVNTMALSTDYA--LRTGAFEPAEASVNPQDLQGSLQELKE 327
Query: 276 PKLVQYLEIVPETRRYPVAVAAAGDLMYLLKAED-SARTLLYAHGPPVTCLDVSANQVAF 334
L +Y + + V+ + L AED T + H NQV F
Sbjct: 328 RALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGH-------QALINQVLF 380
Query: 335 GVQG--LGWVYEGSKILVYSLEAGRRLLKL-GNVLRDFTCVNLSDSPPNLMVSGNMDGRV 391
+ I ++ G+ L L G+V + +DS L+VSG+ D +
Sbjct: 381 SPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADS--RLLVSGSSDSTL 438
Query: 392 RIHDLRSGNIALSLSAHQLRVSAVQM--DDWKIVSGGEEGLVSVW 434
++ D+++ +A+ L H V AV D ++ SGG++ + +W
Sbjct: 439 KVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 33.5 bits (75), Expect = 0.50
Identities = 23/74 (31%), Positives = 35/74 (47%), Gaps = 9/74 (12%)
Query: 381 LMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDWK-----IVSGGEEGLVSVWD 435
++ S + D +++ D R+G SL H V+AV W +VSG + + VWD
Sbjct: 386 IVASASFDKSIKLWDGRTGKYLASLRGH---VAAVYQIAWSADSRLLVSGSSDSTLKVWD 442
Query: 436 YRMNQKLWEVYSGH 449
+ QKL GH
Sbjct: 443 VKA-QKLAMDLPGH 455
Score = 30.8 bits (68), Expect = 3.2
Identities = 18/70 (25%), Positives = 33/70 (47%), Gaps = 2/70 (2%)
Query: 382 MVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQM--DDWKIVSGGEEGLVSVWDYRMN 439
+ SG+ D VR DL + + H+ V ++ D K+ SG + G + +WD
Sbjct: 129 LASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTG 188
Query: 440 QKLWEVYSGH 449
+++ +GH
Sbjct: 189 KQVGRTLAGH 198
Score = 29.6 bits (65), Expect = 7.2
Identities = 23/100 (23%), Positives = 42/100 (42%), Gaps = 17/100 (17%)
Query: 156 VVIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDEPGMQPNVSFV-----RINSSLAVAAY 210
+V + +++WD RT Y+A ++ +V+ V +S L V+
Sbjct: 386 IVASASFDKSIKLWDGRTGKYLA------------SLRGHVAAVYQIAWSADSRLLVSGS 433
Query: 211 EDGFLNIWDLRTGKYPVHRFEHDARIQALALSQDDATVAT 250
D L +WD++ K + H + A+ S D VA+
Sbjct: 434 SDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVAS 473
>gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens]
Length = 491
Score = 42.0 bits (97), Expect = 0.001
Identities = 24/76 (31%), Positives = 35/76 (46%), Gaps = 4/76 (5%)
Query: 15 EELAQAQAPKKRRRPEAAERRARRPENEMNDVPFFDIQLPYELAINIFQYLDRKELGRCA 74
E +A +P R R A RP+ E + +LP + IF +L +L RCA
Sbjct: 83 ETVAMVHSPPPTRLTHPLIRLASRPQKEQASID----RLPDHSMVQIFSFLPTNQLCRCA 138
Query: 75 QVSKTWKVIAEDEVLW 90
+V + W +A D LW
Sbjct: 139 RVCRRWYNLAWDPRLW 154
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 40.8 bits (94), Expect = 0.003
Identities = 29/127 (22%), Positives = 58/127 (45%), Gaps = 8/127 (6%)
Query: 376 DSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDWK--IVSGGEEGLVSV 433
++P L+V+G+ G +R+ DL + I +L H+ + ++ + + SG ++ + +
Sbjct: 72 NTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKL 131
Query: 434 WDYRMNQKLWEVYSGH--PVQHISFSSHSLITANVPYQTVMRNADLDS---FTTHRRHRG 488
WD R ++ Y GH V+ + FS A+ ++ DL + + H G
Sbjct: 132 WDIRRKGCVFR-YRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTG 190
Query: 489 LIRAYEF 495
+ EF
Sbjct: 191 PVNVVEF 197
Score = 33.9 bits (76), Expect = 0.38
Identities = 27/111 (24%), Positives = 48/111 (43%), Gaps = 9/111 (8%)
Query: 150 VHSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDEPGMQPNVSFVRINSSLAVAA 209
+++ + +++AG SG +RVWD + + + P FV S
Sbjct: 71 LNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGS------ 124
Query: 210 YEDGFLNIWDLRTGKYPVHRFE-HDARIQALALSQDDATVATASAFDVVML 259
+D + +WD+R K V R+ H ++ L S D +A+A+ V L
Sbjct: 125 -QDTNIKLWDIRR-KGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKL 173
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,597,115
Number of Sequences: 37866
Number of extensions: 883835
Number of successful extensions: 3585
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 77
Number of HSP's successfully gapped in prelim test: 121
Number of HSP's that attempted gapping in prelim test: 3016
Number of HSP's gapped (non-prelim): 547
length of query: 532
length of database: 18,247,518
effective HSP length: 107
effective length of query: 425
effective length of database: 14,195,856
effective search space: 6033238800
effective search space used: 6033238800
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.