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Search of human proteins with 122937257
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|122937257 thrombospondin, type I, domain containing 7B [Homo
sapiens]
(1577 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|122937257 thrombospondin, type I, domain containing 7B [Homo ... 3434 0.0
gi|150170672 thrombospondin, type I, domain containing 7A [Homo ... 1766 0.0
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 177 7e-44
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 163 1e-39
gi|110347423 spondin 1, extracellular matrix protein [Homo sapiens] 144 9e-34
gi|134031945 SCO-spondin [Homo sapiens] 143 1e-33
gi|118572606 hemicentin 1 [Homo sapiens] 112 4e-24
gi|147904700 semaphorin 5A [Homo sapiens] 103 1e-21
gi|223718260 ADAMTS-like 2 precursor [Homo sapiens] 102 3e-21
gi|41281450 ADAMTS-like 2 precursor [Homo sapiens] 102 3e-21
gi|169174934 PREDICTED: similar to ADAMTS-like 2 [Homo sapiens] 102 3e-21
gi|91982767 semaphorin 5B isoform 1 [Homo sapiens] 101 7e-21
gi|94536854 thrombospondin, type I, domain containing 4 [Homo sa... 97 2e-19
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 93 2e-18
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 90 2e-17
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 89 3e-17
gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo s... 89 3e-17
gi|115387099 brain-specific angiogenesis inhibitor 2 [Homo sapiens] 87 2e-16
gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens] 80 2e-14
gi|4505737 complement factor properdin precursor [Homo sapiens] 77 2e-13
gi|223671861 complement factor properdin precursor [Homo sapiens] 77 2e-13
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 76 2e-13
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 75 4e-13
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 75 4e-13
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 75 4e-13
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 75 4e-13
gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [... 75 5e-13
gi|40317626 thrombospondin 1 precursor [Homo sapiens] 75 7e-13
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 74 1e-12
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 73 2e-12
>gi|122937257 thrombospondin, type I, domain containing 7B [Homo
sapiens]
Length = 1577
Score = 3434 bits (8904), Expect = 0.0
Identities = 1577/1577 (100%), Positives = 1577/1577 (100%)
Query: 1 MHNTADEVVLYHKLAGPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKER 60
MHNTADEVVLYHKLAGPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKER
Sbjct: 1 MHNTADEVVLYHKLAGPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKER 60
Query: 61 SCFRVCDWHSDLFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNR 120
SCFRVCDWHSDLFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNR
Sbjct: 61 SCFRVCDWHSDLFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNR 120
Query: 121 TVVANEICEHFALQPPTEQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPL 180
TVVANEICEHFALQPPTEQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPL
Sbjct: 121 TVVANEICEHFALQPPTEQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPL 180
Query: 181 FGGLQCPNLTESRACDAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNS 240
FGGLQCPNLTESRACDAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNS
Sbjct: 181 FGGLQCPNLTESRACDAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNS 240
Query: 241 DSNERVTFKHQSYKAHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSC 300
DSNERVTFKHQSYKAHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSC
Sbjct: 241 DSNERVTFKHQSYKAHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSC 300
Query: 301 IMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVE 360
IMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVE
Sbjct: 301 IMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVE 360
Query: 361 GELLQQCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAA 420
GELLQQCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAA
Sbjct: 361 GELLQQCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAA 420
Query: 421 LRAKEVSRPVEKALCVGPAPLPSQLCNIPCSTDCIVSSWSAWGLCIHENCHDPQGKKGFR 480
LRAKEVSRPVEKALCVGPAPLPSQLCNIPCSTDCIVSSWSAWGLCIHENCHDPQGKKGFR
Sbjct: 421 LRAKEVSRPVEKALCVGPAPLPSQLCNIPCSTDCIVSSWSAWGLCIHENCHDPQGKKGFR 480
Query: 481 TRQRHVLMESTGPAGHCPHLVESVPCEDPMCYRWLASEGICFPDHGKCGLGHRILKAVCQ 540
TRQRHVLMESTGPAGHCPHLVESVPCEDPMCYRWLASEGICFPDHGKCGLGHRILKAVCQ
Sbjct: 481 TRQRHVLMESTGPAGHCPHLVESVPCEDPMCYRWLASEGICFPDHGKCGLGHRILKAVCQ 540
Query: 541 NDRGEDVSGSLCPVPPPPERKSCEIPCRMDCVLSEWTEWSSCSQSCSNKNSDGKQTRSRT 600
NDRGEDVSGSLCPVPPPPERKSCEIPCRMDCVLSEWTEWSSCSQSCSNKNSDGKQTRSRT
Sbjct: 541 NDRGEDVSGSLCPVPPPPERKSCEIPCRMDCVLSEWTEWSSCSQSCSNKNSDGKQTRSRT 600
Query: 601 ILALAGEGGKPCPPSQALQEHRLCNDHSCMQLHWETSPWGPCSEDTLVTALNATIGWNGE 660
ILALAGEGGKPCPPSQALQEHRLCNDHSCMQLHWETSPWGPCSEDTLVTALNATIGWNGE
Sbjct: 601 ILALAGEGGKPCPPSQALQEHRLCNDHSCMQLHWETSPWGPCSEDTLVTALNATIGWNGE 660
Query: 661 ATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPETVRPCFLPCKKDCIVTAFSEWTPCPR 720
ATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPETVRPCFLPCKKDCIVTAFSEWTPCPR
Sbjct: 661 ATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPETVRPCFLPCKKDCIVTAFSEWTPCPR 720
Query: 721 MCQAGNATVKQSRYRIIIQEAANGGQECPDTLYEERECEDVSLCPVYRWKPQKWSPCILV 780
MCQAGNATVKQSRYRIIIQEAANGGQECPDTLYEERECEDVSLCPVYRWKPQKWSPCILV
Sbjct: 721 MCQAGNATVKQSRYRIIIQEAANGGQECPDTLYEERECEDVSLCPVYRWKPQKWSPCILV 780
Query: 781 PESVWQGITGSSEACGKGLQTRAVSCISDDNRSAEMMECLKQTNGMPLLVQECTVPCRED 840
PESVWQGITGSSEACGKGLQTRAVSCISDDNRSAEMMECLKQTNGMPLLVQECTVPCRED
Sbjct: 781 PESVWQGITGSSEACGKGLQTRAVSCISDDNRSAEMMECLKQTNGMPLLVQECTVPCRED 840
Query: 841 CTFTAWSKFTPCSTNCEATKSRRRQLTGKSRKKEKCQDSDLYPLVETELCPCDEFISQPY 900
CTFTAWSKFTPCSTNCEATKSRRRQLTGKSRKKEKCQDSDLYPLVETELCPCDEFISQPY
Sbjct: 841 CTFTAWSKFTPCSTNCEATKSRRRQLTGKSRKKEKCQDSDLYPLVETELCPCDEFISQPY 900
Query: 901 GNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSDKNGRPVDPSFCSSSGYIQE 960
GNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSDKNGRPVDPSFCSSSGYIQE
Sbjct: 901 GNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSDKNGRPVDPSFCSSSGYIQE 960
Query: 961 KCVIPCPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHE 1020
KCVIPCPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHE
Sbjct: 961 KCVIPCPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHE 1020
Query: 1021 AVPCYSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCN 1080
AVPCYSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCN
Sbjct: 1021 AVPCYSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCN 1080
Query: 1081 QDEIPPETQSCSLMCPNECVMSEWGLWSKCPQSCDPHTMQRRTRHLLRPSLNSRTCAEDS 1140
QDEIPPETQSCSLMCPNECVMSEWGLWSKCPQSCDPHTMQRRTRHLLRPSLNSRTCAEDS
Sbjct: 1081 QDEIPPETQSCSLMCPNECVMSEWGLWSKCPQSCDPHTMQRRTRHLLRPSLNSRTCAEDS 1140
Query: 1141 QVQPCLLNENCFQFQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHN 1200
QVQPCLLNENCFQFQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHN
Sbjct: 1141 QVQPCLLNENCFQFQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHN 1200
Query: 1201 LEKPQRMSIPCLVECVVNCQLSGWTAWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPTE 1260
LEKPQRMSIPCLVECVVNCQLSGWTAWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPTE
Sbjct: 1201 LEKPQRMSIPCLVECVVNCQLSGWTAWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPTE 1260
Query: 1261 LTQEKTCPVTPCYSWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALC 1320
LTQEKTCPVTPCYSWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALC
Sbjct: 1261 LTQEKTCPVTPCYSWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALC 1320
Query: 1321 GEMPFQDSILKQLCSVPCPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQSF 1380
GEMPFQDSILKQLCSVPCPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQSF
Sbjct: 1321 GEMPFQDSILKQLCSVPCPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQSF 1380
Query: 1381 ENQDSCPQQVLETRPCTGGKCYHYTWKASLWNNNERTVWCQRSDGVNVTGGCSPQARPAA 1440
ENQDSCPQQVLETRPCTGGKCYHYTWKASLWNNNERTVWCQRSDGVNVTGGCSPQARPAA
Sbjct: 1381 ENQDSCPQQVLETRPCTGGKCYHYTWKASLWNNNERTVWCQRSDGVNVTGGCSPQARPAA 1440
Query: 1441 IRQCIPACRKPFSYCTQGGVCGCEKGYTEIMKSNGFLDYCMKVPGSEDKKADVKNLSGKN 1500
IRQCIPACRKPFSYCTQGGVCGCEKGYTEIMKSNGFLDYCMKVPGSEDKKADVKNLSGKN
Sbjct: 1441 IRQCIPACRKPFSYCTQGGVCGCEKGYTEIMKSNGFLDYCMKVPGSEDKKADVKNLSGKN 1500
Query: 1501 RPVNSKIHDIFKGWSLQPLDPDGRVKIWVYGVSGGAFLIMIFLIFTSYLVCKKPKPHQST 1560
RPVNSKIHDIFKGWSLQPLDPDGRVKIWVYGVSGGAFLIMIFLIFTSYLVCKKPKPHQST
Sbjct: 1501 RPVNSKIHDIFKGWSLQPLDPDGRVKIWVYGVSGGAFLIMIFLIFTSYLVCKKPKPHQST 1560
Query: 1561 PPQQKPLTLAYDGDLDM 1577
PPQQKPLTLAYDGDLDM
Sbjct: 1561 PPQQKPLTLAYDGDLDM 1577
>gi|150170672 thrombospondin, type I, domain containing 7A [Homo
sapiens]
Length = 1657
Score = 1766 bits (4574), Expect = 0.0
Identities = 815/1612 (50%), Positives = 1072/1612 (66%), Gaps = 46/1612 (2%)
Query: 5 ADEVVLYHKLAGPWGRCTGD-CGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCF 63
A+ LY GPWGRC GD CGPGG+Q+RAVWC HV+GWT+ +NC ++ RP +++CF
Sbjct: 53 AEAPTLYLWKTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCF 112
Query: 64 RVCDWHSDLFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVV 123
+VCDWH +L+ W + W+ C V ++ KP EC+ + G+Q R + CIQK
Sbjct: 113 KVCDWHKELYDWRLGPWNQCQPV-ISKSLEKP--LECIKGEEGIQVREIACIQKDKDIPA 169
Query: 124 ANEICEHFALQPPTEQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGG 183
+ ICE+F +P EQACLIPC +DC+VSEF WS CSK CG LQHRTR V+APP FGG
Sbjct: 170 EDIICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGG 229
Query: 184 LQCPNLTESRACDAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDSN 243
CPNLTE + C S P EE +SL VGPWS C +PH +++ + R + + +
Sbjct: 230 SGCPNLTEFQVCQ---SSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKD 286
Query: 244 ERVTFK------------HQSYKAHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQD 291
K +++ + +K W I+IGYQTR+V C G+ A LS C Q+
Sbjct: 287 RSKGVKDPEARELIKKKRNRNRQNRQENKYWDIQIGYQTREVMCINKTGKAADLSFCQQE 346
Query: 292 SFPLTVQSCIMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPEL 351
P+T QSC++ K+C+ S+WS WSPCSKTC G R R+R ++ IG KECPE
Sbjct: 347 KLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEF 406
Query: 352 LEKEACIVEGELLQQCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYC 411
EKE C+ +G+ + C Y WRT+EW EC+V LL QQD +CGGGIQTREVYC
Sbjct: 407 EEKEPCLSQGDGVVPCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYC 466
Query: 412 AQS----VPAAAALRAKEVSRPVEKALCVGPAPLPSQLCNIPCSTDCIVSSWSAWGLCIH 467
Q+ + + + KE S+P++ LC GP P +QLC+IPC T+C VS WSAWG C +
Sbjct: 467 VQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHIPCPTECEVSPWSAWGPCTY 526
Query: 468 ENCHDPQGKKGFRTRQRHVLMESTGPAG---HCPHLVESVPCEDPMCYRWLASE-GICFP 523
ENC+D QGKKGF+ R+R + E TG +G +CPHL+E++PCE+P CY W A G C P
Sbjct: 527 ENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEP 586
Query: 524 DHGK-CGLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSCEIPCRMDCVLSEWTEWSSC 582
D+GK CG G ++ + VC N GE+V LC P +C+ PC DCVLS W+ WSSC
Sbjct: 587 DNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSC 646
Query: 583 SQSCSNKNSDGKQTRSRTILALAGE-GGKPCPPSQALQEHRLCNDHSCMQLHWETSPWGP 641
S +CS K ++GKQ R+R+ILA AGE GG CP S ALQE R CN+H C HW+T PWG
Sbjct: 647 SHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVYHWQTGPWGQ 706
Query: 642 CSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPETVRPCFL 701
C EDT V++ N T WNGEA+C VG+QTR+V CV+ +VGQV K+CP+S RPETVRPC L
Sbjct: 707 CIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLL 766
Query: 702 PCKKDCIVTAFSEWTPCPRMCQAGNATV-KQSRYRIIIQEAANGGQECPDTLYEERECED 760
PCKKDCIVT +S+WT CP C+ G++++ KQSR+R+IIQ ANGG++C D LYEE+ CE
Sbjct: 767 PCKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEA 826
Query: 761 VSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCISDDNRSAEMMECL 820
C YRWK KW C LVP SV Q G+ E CG G Q RA++C D A + ECL
Sbjct: 827 PQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECL 886
Query: 821 KQTNGMPLLVQECTVPCREDCTFTAWSKFTPCSTNCEATKSRRRQLTGKSRKKEKCQDSD 880
+ +P L Q C +PC++DC T+WSKF+ C+ +C A ++R+R L GKS+KKEKC++S
Sbjct: 887 QYAGPVPALTQACQIPCQDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSH 946
Query: 881 LYPLVETELCPCDEFISQPYGNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACS 940
LYPL+ET+ CPCD++ +QP GNWSDCILPEG+ E G++VQ D KECG+G R++A+AC
Sbjct: 947 LYPLIETQYCPCDKYNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACY 1006
Query: 941 DKNGRPVDPSFCSSSGYIQEKCVIPCPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKP 1000
D+NGR V+ S C+S GYI+E C+IPCP DCKLS+WS+W CS SCG GV++RSKWL+EKP
Sbjct: 1007 DQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKP 1066
Query: 1001 YNGGRPCPKLDLKNQAQVHEAVPCYSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRK 1060
YNGGRPCPKLD NQAQV+E VPC+S+CNQY WV E WS CK+ CG G Q+RK
Sbjct: 1067 YNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRK 1126
Query: 1061 IRCV-NTADGEGGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEWGLWSKCPQSCDPHTM 1119
+RC+ NTADG V+ LC+ +E+P ++ C L CP +CV+SEWG W++C C+ +
Sbjct: 1127 VRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSF 1186
Query: 1120 QRRTRHLLR-PSLNSRTCAEDSQVQPCLLNENCFQFQYNLTEWSTCQLSENAPCGQGVRT 1178
++R+ +R P+ R+C + +PC LN+NC+ + YN+T+WSTCQLSE A CG G++T
Sbjct: 1187 RQRSADPIRQPADEGRSCPNAVEKEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKT 1246
Query: 1179 RLLSCVCSDGKPVSMDQCEQHNLEKPQRMSIPCLVECVVNCQLSGWTAWTECSQTCGHGG 1238
R+L CV SDGK V + CE LEK +M+ C+VEC VNCQLS W+ W+ECSQTCG G
Sbjct: 1247 RMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTG 1306
Query: 1239 RMSRTRFIIMPTQGEGRPCPTELTQEKTCPVTPCYSWVLGNWSACKLEGGDCGEGVQIRS 1298
+M R R + P QG+GRPCP+ + Q K CPV PCY W G WS C+++ CGEG + R+
Sbjct: 1307 KMIRRRTVTQPFQGDGRPCPSLMDQSKPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRN 1366
Query: 1299 LSCMVHSGSISHAAGRVEDALCGEMPF-----QDSILKQLCSVPCPGDCHLTEWSEWSTC 1353
+SC+V GS + V++ C ++ ++ +L++ CS PCPGDC+L +WS WS C
Sbjct: 1367 ISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQPCPGDCYLKDWSSWSLC 1426
Query: 1354 ELTCIDGRSFETVGRQSRSRTFIIQSFENQDSCPQQVLETRPCTGGKCYHYTWKASLWNN 1413
+LTC++G G Q RSR IIQ ENQ CP+Q+LET+ C G+CY Y W AS W
Sbjct: 1427 QLTCVNGEDLGFGGIQVRSRPVIIQELENQHLCPEQMLETKSCYDGQCYEYKWMASAWKG 1486
Query: 1414 NERTVWCQRSDGVNVTGGCSPQARPAAIRQCIPACRKPFSYCTQGGVCGCEKGYTEIMKS 1473
+ RTVWCQRSDG+NVTGGC ++P A R C P C +P SYC++ C CE+GYTE+M S
Sbjct: 1487 SSRTVWCQRSDGINVTGGCLVMSQPDADRSCNPPCSQPHSYCSETKTCHCEEGYTEVMSS 1546
Query: 1474 NGFLDYC-----MKVPGSEDKKADVKNLSGKNRPVNSKIHDIFKG--WSLQPLDPDGRVK 1526
N L+ C + +P EDK+ DVK S P + +G W LQP PDGR+K
Sbjct: 1547 NSTLEQCTLIPVVVLPTMEDKRGDVKT-SRAVHPTQPSSNPAGRGRTWFLQPFGPDGRLK 1605
Query: 1527 IWVYGVSGGAFLIMIFLIFTSYLVCKKP-KPHQSTPPQQKPLTLAYDGDLDM 1577
WVYGV+ GAF+++IF++ YL CKKP KP + + KPLTLAYDGD DM
Sbjct: 1606 TWVYGVAAGAFVLLIFIVSMIYLACKKPKKPQRRQNNRLKPLTLAYDGDADM 1657
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 177 bits (449), Expect = 7e-44
Identities = 217/969 (22%), Positives = 331/969 (34%), Gaps = 252/969 (26%)
Query: 457 SSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHCP---HLVESVPCEDPMCYR 513
+S W C + C + +K TR+ L S P H+ E PC R
Sbjct: 882 NSHGPWQAC-SKPCQGERKRKLVCTRESDQLTVSDQRCDRLPQPGHITE--PCGTDCDLR 938
Query: 514 W-LASEGICFPDHGKCGLGHRILKAVCQ-----NDRGEDVSGSLCPVPPPPERKSCEIPC 567
W +AS C +CGLG+R L C + + E V C P P + C
Sbjct: 939 WHVASRSEC---SAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNRE---KC 992
Query: 568 RMDCVLSEW--TEWSSCSQSCSN------------------------------------- 588
+C W + W+ CS+SC
Sbjct: 993 SGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVTIQRCSEFP 1052
Query: 589 ----KNSD--------GKQTRSRTILALAGE---GGKPCPPSQALQEHRLCNDHSCMQLH 633
K+ D GK + R + GE + C P + C C
Sbjct: 1053 CPQWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPECAS-- 1110
Query: 634 WETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCV-KSHVGQVMTKRCPDSTR 692
W+ PWG CS TCG G Q R V C+ +++ V C +TR
Sbjct: 1111 WQAGPWGQCS-----------------VTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATR 1153
Query: 693 PETVRPCFLPC---------KKDCIVTA------FSEWTPCPRMCQAGNATVKQSRYRII 737
P + C LP + +A F WTPC C G +R R +
Sbjct: 1154 PTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKG------TRMRYV 1207
Query: 738 IQEAANGG---QECPDTLYEERECEDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEA 794
NG + TL E+ S+ P +WK WS C S
Sbjct: 1208 SCRDENGSVADESACATLPRPVAKEECSVTPCGQWKALDWSSC--------------SVT 1253
Query: 795 CGKGLQTRAVSCISDDNRSAEMMECLKQTNGMPLLVQECTVPCREDCTFTAWSKFTPCST 854
CG+G TR V C++ + + EC + +P Q+C++ +PC
Sbjct: 1254 CGQGRATRQVMCVNYSDHVIDRSEC--DQDYIPETDQDCSM--------------SPCPQ 1297
Query: 855 NCEATKSRRRQLTGKSRKKEKCQDSDLYPLVETELCPCDEFISQPYGNWSDCILPEGRRE 914
+ + + + S T + +++ + P+G
Sbjct: 1298 RTPDSGLAQHPFQNEDYRPRSASPS------RTHVLGGNQWRTGPWG------------- 1338
Query: 915 PHRGLRVQADSKECGEGLRFRAVACSDKNGRPVDPSFCSSSGYIQEKCVI-PCPFDCKLS 973
A S C G + R V C D+NG + Q C PCP
Sbjct: 1339 --------ACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCP------ 1384
Query: 974 DWS--SWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHEAVPCYSECNQY 1031
W+ +WG C+ CG G+R R L + G P L ++ + P +CN +
Sbjct: 1385 QWAYGNWGECTKLCGGGIRTR---LVVCQRSNGERFPDLS----CEILDKPPDREQCNTH 1437
Query: 1032 S------WVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIP 1085
+ W WSSC ++ CG G + R + C+ +G ++S+ C P
Sbjct: 1438 ACPHDAAWSTGPWSSCSVS-------CGRGHKQRNVYCMAK---DGSHLESDYCKHLAKP 1487
Query: 1086 PETQSCSLMCPNECVMSEWGLWSKCPQSCDPHTMQRRTRHLLRPSLNSRTCAEDSQVQPC 1145
+ C C + G WS+C SC QR + + + A +++ P
Sbjct: 1488 HGHRKCR---GGRCPKWKAGAWSQCSVSCGRGVQQRH----VGCQIGTHKIARETECNPY 1540
Query: 1146 LLNEN--------CFQFQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCE 1197
E+ C + + EW C + CG+G R R + CV + V +C+
Sbjct: 1541 TRPESERDCQGPRCPLYTWRAEEWQECTKT----CGEGSRYRKVVCVDDNKNEVHGARCD 1596
Query: 1198 --QHNLEKPQRMSIPCLVECVVNCQLSGWTAWTECSQTCGHGGRMSRTRFIIMPTQGEGR 1255
+ +++ PC + W+ECS TCG G + + T E
Sbjct: 1597 VSKRPVDRESCSLQPCEYVWITG-------EWSECSVTCGKGYKQRLVSCSEIYTGKENY 1649
Query: 1256 PCPTELTQEKTCPVT------PCY--------SWVLGNWSACKLEGGDCGEGVQIRSLSC 1301
+ T CP T PCY +W +GNW +C + CG GV RS+ C
Sbjct: 1650 EYSYQTTIN--CPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVS---CGVGVMQRSVQC 1704
Query: 1302 MVHSGSISH 1310
+ + SH
Sbjct: 1705 LTNEDQPSH 1713
Score = 157 bits (396), Expect = 1e-37
Identities = 214/907 (23%), Positives = 327/907 (36%), Gaps = 213/907 (23%)
Query: 266 IGYQTRQVSC---TRSDGQNAMLS--LCLQDSFPLTVQSCIMPKDCETSQW--SSWSPCS 318
+GY+T + C +R DG+ + C P + C +C T W S+W+ CS
Sbjct: 953 LGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKC--SGECNTGGWRYSAWTECS 1010
Query: 319 KTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEGEL-LQQCPRY---SWRT 374
K+C G+ R+ N ++ ++L+ C + ++ +Q+C + W++
Sbjct: 1011 KSCDGGTQRR--RAICVNTRN----------DVLDDSKCTHQEKVTIQRCSEFPCPQWKS 1058
Query: 375 SEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKAL 434
+W EC V+ CG G + R+V+C ++P
Sbjct: 1059 GDWSECLVT----------------CGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQT 1102
Query: 435 CVGPAPLPSQL-----CNIPC-------STDCIVSSWSAWGLCIHENCHDPQGKKGFRTR 482
C P Q C++ C + CI+ ++ + + +N + + T
Sbjct: 1103 CQQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMS---VVDDNDCNAATRP---TD 1156
Query: 483 QRHVLMESTGPAGHCPHLVESVPCEDPMCYRWLASEGICFPDHGKCGLGHRILKAVCQND 542
+ + S P P S +R+ G P CG G R+ C+++
Sbjct: 1157 TQDCELPSCHPPPAAPETRRSTYSAPRTQWRF----GSWTPCSATCGKGTRMRYVSCRDE 1212
Query: 543 RGEDVSGSLCP-VPPPPERKSCEI-PCRMDCVLSEWT--EWSSCSQSCSNKN-------- 590
G S C +P P ++ C + PC +W +WSSCS +C
Sbjct: 1213 NGSVADESACATLPRPVAKEECSVTPC------GQWKALDWSSCSVTCGQGRATRQVMCV 1266
Query: 591 --SDGKQTRSRTILALAGEGGK-----PCP---PSQALQEHRLCND------------HS 628
SD RS E + PCP P L +H N+ H
Sbjct: 1267 NYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHV 1326
Query: 629 CMQLHWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCP 688
W T PWG CS +TC G Q R V C + C
Sbjct: 1327 LGGNQWRTGPWGACS-----------------STCAGGSQRRVVVCQDEN--GYTANDCV 1367
Query: 689 DSTRPETVRPCFL-PCKKDCIVTAFSEWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQE 747
+ +P+ R C PC + A+ W C ++C G T R+++ + +NG +
Sbjct: 1368 ERIKPDEQRACESGPCPQ----WAYGNWGECTKLCGGGIRT------RLVVCQRSNG-ER 1416
Query: 748 CPDTLYE------ERECEDVSLCPV-YRWKPQKWSPCILVPESVWQGITGSSEACGKGLQ 800
PD E +RE + CP W WS C S +CG+G +
Sbjct: 1417 FPDLSCEILDKPPDREQCNTHACPHDAAWSTGPWSSC--------------SVSCGRGHK 1462
Query: 801 TRAVSCISDDNRSAEMMEC--LKQTNGMPLLVQECTVPCREDCTFTAWSKFTPCSTNCEA 858
R V C++ D E C L + +G ++C AWS+ CS +C
Sbjct: 1463 QRNVYCMAKDGSHLESDYCKHLAKPHGH----RKCRGGRCPKWKAGAWSQ---CSVSCGR 1515
Query: 859 TKSRRRQLTGKSRKKEKCQDSDLYPLVETELCPCDEFISQPYGNWSDCILPEGRREPHRG 918
G ++ CQ ETE P S+ DC P R
Sbjct: 1516 ---------GVQQRHVGCQIGTHKIARETECNPYTRPESE-----RDCQGPRCPLYTWRA 1561
Query: 919 LRVQADSKECGEGLRFRAVACSDKNGRPVDPSFC--SSSGYIQEKCVI-PCPFDCKLSDW 975
Q +K CGEG R+R V C D N V + C S +E C + PC + +W
Sbjct: 1562 EEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEYVWITGEW 1621
Query: 976 SSWGSCSSSCGIGVRIR---------SKWLKEKPYNGGRPCPKLDLKNQAQVHEAVPCY- 1025
S CS +CG G + R K E Y CP Q PCY
Sbjct: 1622 S---ECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCP------GTQPPSVHPCYL 1672
Query: 1026 SECN-QYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEI 1084
+C +W V +W SC S+ CG G R ++C+ D S+LC+ D
Sbjct: 1673 RDCPVSATWRVGNWGSC-------SVSCGVGVMQRSVQCLTNED-----QPSHLCHTDLK 1720
Query: 1085 PPETQSC 1091
P E ++C
Sbjct: 1721 PEERKTC 1727
Score = 137 bits (345), Expect = 8e-32
Identities = 211/909 (23%), Positives = 331/909 (36%), Gaps = 186/909 (20%)
Query: 390 DPHWHVTG-----PVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKALCVGPAPLPSQ 444
D WHV CG G +T ++YCA+ R + V+ C P PS
Sbjct: 936 DLRWHVASRSECSAQCGLGYRTLDIYCAK------YSRLDGKTEKVDDGFC-SSHPKPSN 988
Query: 445 LCNIPCSTDCIVSSW--SAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPH--L 500
CS +C W SAW C Q ++ R+ +++ + C H
Sbjct: 989 --REKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDS----KCTHQEK 1042
Query: 501 VESVPCEDPMCYRWLASE-GICFPDHGKCGLGHRILKAVCQNDRGED-VSGSLC-PVPPP 557
V C + C +W + + C CG GH+ + CQ GED ++ +C P P
Sbjct: 1043 VTIQRCSEFPCPQWKSGDWSECLV---TCGKGHKHRQVWCQ--FGEDRLNDRMCDPETKP 1097
Query: 558 PERKSCEIPCRMDCVLSEWTEWSSCSQSCSNKNSDGKQTRS-----RTILALAGEGG--- 609
++C+ P +C + W CS +C G Q R+ T +++ +
Sbjct: 1098 TSMQTCQQP---ECASWQAGPWGQCSVTC----GQGYQLRAVKCIIGTYMSVVDDNDCNA 1150
Query: 610 ------------KPCPPSQALQEHRLCNDHSCMQLHWETSPWGPCSEDTLVTALNATIGW 657
C P A E R + +S + W W PCS
Sbjct: 1151 ATRPTDTQDCELPSCHPPPAAPETRR-STYSAPRTQWRFGSWTPCS-------------- 1195
Query: 658 NGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPETVRPCFL-PCKKDCIVTAFSEWT 716
ATCG G + R V C + C RP C + PC + +W+
Sbjct: 1196 ---ATCGKGTRMRYVSCRDENGSVADESACATLPRPVAKEECSVTPCGQ----WKALDWS 1248
Query: 717 PCPRMCQAGNAT--VKQSRYRIIIQEAANGGQE-CPDTLYEERECEDVSLCPVYR----- 768
C C G AT V Y + + + Q+ P+T +++C +S CP
Sbjct: 1249 SCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPET---DQDC-SMSPCPQRTPDSGL 1304
Query: 769 ---------WKPQKWSPC---ILVPESVWQGITGS-SEACGKGLQTRAVSCISDDNRSAE 815
++P+ SP +L G G+ S C G Q R V C ++ +A
Sbjct: 1305 AQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTAN 1364
Query: 816 MMECLKQTNGMPLLVQEC-TVPCREDCTFTAWSKFTPCSTNCEATKSRRRQLTGKSRKKE 874
+C+++ P + C + PC + A+ + C+ C R + +S +
Sbjct: 1365 --DCVERIK--PDEQRACESGPCPQ----WAYGNWGECTKLCGGGIRTRLVVCQRSNGER 1416
Query: 875 ----KCQDSDLYPLVE---TELCPCDEFISQPYGNWSDCILPEGRREPHRGLRVQADSKE 927
C+ D P E T CP D S G WS C S
Sbjct: 1417 FPDLSCEILDKPPDREQCNTHACPHDAAWST--GPWSSC------------------SVS 1456
Query: 928 CGEGLRFRAVACSDKNGRPVDPSFCS--SSGYIQEKCVIPCPFDCKLSDWSSWGSCSSSC 985
CG G + R V C K+G ++ +C + + KC C +W CS SC
Sbjct: 1457 CGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKC---RGGRCPKWKAGAWSQCSVSC 1513
Query: 986 GIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHEAVPCYS-ECNQYSWVVEHWSSCKIN 1044
G GV+ R + + R + + + C C Y+W E W C
Sbjct: 1514 GRGVQQRHVGCQIGTHKIAR---ETECNPYTRPESERDCQGPRCPLYTWRAEEWQEC--- 1567
Query: 1045 NELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEW 1104
+ CG G++ RK+ CV D V C+ + P + +SCSL P E V
Sbjct: 1568 ----TKTCGEGSRYRKVVCV---DDNKNEVHGARCDVSKRPVDRESCSLQ-PCEYVWIT- 1618
Query: 1105 GLWSKCPQSC------------DPHTMQRRTRHLLRPSLNSRTCAEDSQVQPCLLNENCF 1152
G WS+C +C + +T + + + ++N + V PC L +
Sbjct: 1619 GEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINC-PGTQPPSVHPCYLRDCPV 1677
Query: 1153 QFQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHNLEKPQRMSIPCL 1212
+ + W +C +S CG GV R + C+ ++ +P + C H KP+
Sbjct: 1678 SATWRVGNWGSCSVS----CGVGVMQRSVQCLTNEDQPSHL--C--HTDLKPEERK---T 1726
Query: 1213 VECVVNCQL 1221
V NC+L
Sbjct: 1727 CRNVYNCEL 1735
Score = 135 bits (339), Expect = 4e-31
Identities = 210/912 (23%), Positives = 310/912 (33%), Gaps = 220/912 (24%)
Query: 631 QLHWET-SPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVK-SHVGQVMTKRCP 688
Q +W + PW CS+ G + R++ C + S V +RC
Sbjct: 878 QFYWNSHGPWQACSKPCQ------------------GERKRKLVCTRESDQLTVSDQRCD 919
Query: 689 DSTRPETV-RPCFLPCKKDCIVTAFSEWTPCPRMCQAGNATV-----KQSRYRIIIQEAA 742
+P + PC C V + SE C C G T+ K SR ++
Sbjct: 920 RLPQPGHITEPCGTDCDLRWHVASRSE---CSAQCGLGYRTLDIYCAKYSRLDGKTEKVD 976
Query: 743 NGGQECPDTLYEERECEDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTR 802
+G +C C W+ W+ C S++C G Q R
Sbjct: 977 DGFCSSHPKPSNREKCSGE--CNTGGWRYSAWTEC--------------SKSCDGGTQRR 1020
Query: 803 AVSCISDDNRSAEMMECLKQTNGMPLLVQECT-VPCREDCTFTAWSK--FTPCSTNCEAT 859
C++ N + +C Q + +Q C+ PC + W ++ C C
Sbjct: 1021 RAICVNTRNDVLDDSKCTHQEK---VTIQRCSEFPCPQ------WKSGDWSECLVTCGKG 1071
Query: 860 KSRRRQLT--GKSRKKEKCQDSDLYPLVETELCPCDEFISQPYGNWSDCILPEGRREPHR 917
R+ G+ R ++ D + P + C E S G W C
Sbjct: 1072 HKHRQVWCQFGEDRLNDRMCDPETKP-TSMQTCQQPECASWQAGPWGQC----------- 1119
Query: 918 GLRVQADSKECGEGLRFRAVAC-----------SDKNG--RPVDPSFCSSSGYIQEKCVI 964
S CG+G + RAV C +D N RP D C C
Sbjct: 1120 -------SVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPS-----CHP 1167
Query: 965 P--------CPFDCKLSDW--SSWGSCSSSCGIGVRIRSKWLKEKPYNGG----RPCPKL 1010
P + + W SW CS++CG G R+R ++ + NG C L
Sbjct: 1168 PPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMR--YVSCRDENGSVADESACATL 1225
Query: 1011 DLKNQAQVHEAVPCYSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGE 1070
+ PC W WSSC S+ CG G +R++ CVN +D
Sbjct: 1226 PRPVAKEECSVTPCGQ------WKALDWSSC-------SVTCGQGRATRQVMCVNYSDH- 1271
Query: 1071 GGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEWGLWSKCPQSCDPHTMQRRTRHLLRPS 1130
+D + C+QD IP Q CS+ S CPQ + +H +
Sbjct: 1272 --VIDRSECDQDYIPETDQDCSM--------------SPCPQRTPDSGL---AQHPFQNE 1312
Query: 1131 LNSRTCAEDSQVQPCLLNENCFQFQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSDGKP 1190
A S+ +L N Q+ W C ++ C G + R++ VC D
Sbjct: 1313 DYRPRSASPSRTH--VLGGN----QWRTGPWGAC----SSTCAGGSQRRVV--VCQDENG 1360
Query: 1191 VSMDQCEQHNLEKPQRM--SIPCLVECVVNCQLSGWTAWTECSQTCGHGGRMSRTRFIIM 1248
+ + C + QR S PC N W EC++ CG G RTR ++
Sbjct: 1361 YTANDCVERIKPDEQRACESGPCPQWAYGN--------WGECTKLCGGG---IRTRLVVC 1409
Query: 1249 P-TQGE----------GRPCPTELTQEKTCPVTPCYSWVLGNWSACKLEGGDCGEGVQIR 1297
+ GE +P E CP +W G WS+C + CG G + R
Sbjct: 1410 QRSNGERFPDLSCEILDKPPDREQCNTHACPHDA--AWSTGPWSSCSVS---CGRGHKQR 1464
Query: 1298 SLSCMVHSGSISHAAGRVEDALCGEMPFQDSILKQLCSVPCPGD-CHLTEWSEWSTCELT 1356
++ CM GS +E C + K C G C + WS C ++
Sbjct: 1465 NVYCMAKDGS------HLESDYCKHLAKPHGHRK------CRGGRCPKWKAGAWSQCSVS 1512
Query: 1357 CIDGRSFETVGRQSRSRTFIIQSFENQDSCPQQVLETRPCTGGKCYHYTWKASLW----- 1411
C G VG Q + ++ N + P+ R C G +C YTW+A W
Sbjct: 1513 CGRGVQQRHVGCQIGTHKIARETECNPYTRPES---ERDCQGPRCPLYTWRAEEWQECTK 1569
Query: 1412 ----NNNERTVWCQRSDGVNVTGG-CSPQARPAAIRQCIPACRKPFSYCTQGGVCG---- 1462
+ R V C + V G C RP C +P Y G
Sbjct: 1570 TCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESC---SLQPCEYVWITGEWSECSV 1626
Query: 1463 -CEKGYTEIMKS 1473
C KGY + + S
Sbjct: 1627 TCGKGYKQRLVS 1638
Score = 128 bits (322), Expect = 4e-29
Identities = 165/658 (25%), Positives = 246/658 (37%), Gaps = 142/658 (21%)
Query: 922 QADSKECGEGLRFRAVACSDKNGR-PVDPSFCS---SSGYIQEKCVIPCPFDCKLSDW-- 975
QA SK C +G R R + C+ ++ + V C G+I E PC DC L W
Sbjct: 888 QACSKPC-QGERKRKLVCTRESDQLTVSDQRCDRLPQPGHITE----PCGTDCDLR-WHV 941
Query: 976 SSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLD---LKNQAQVHEAVPCYSECNQYS 1032
+S CS+ CG+G R + + G+ K+D + + C ECN
Sbjct: 942 ASRSECSAQCGLGYRTLDIYCAKYSRLDGKT-EKVDDGFCSSHPKPSNREKCSGECNTGG 1000
Query: 1033 WVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQSCS 1092
W W+ C S C GGTQ R+ CVNT + +D + C E +
Sbjct: 1001 WRYSAWTEC-------SKSCDGGTQRRRAICVNTRND---VLDDSKCTHQEKVTIQRCSE 1050
Query: 1093 LMCPNECVMSEW--GLWSKCPQSCDP-HTMQRRTRHLLRPSLNSRTCAEDSQ---VQPCL 1146
CP +W G WS+C +C H ++ LN R C +++ +Q C
Sbjct: 1051 FPCP------QWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQ 1104
Query: 1147 LNENCFQFQYNLTEWSTCQLSENAPCGQGVRTRLLSCV------------CSDG-KPVSM 1193
E C +Q W C ++ CGQG + R + C+ C+ +P
Sbjct: 1105 QPE-CASWQAG--PWGQCSVT----CGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDT 1157
Query: 1194 DQCEQHNLEKPQRMSIPCLVECVVNCQLSGWT--AWTECSQTCGHGGRMS----RTRFII 1247
CE + P + P + + W +WT CS TCG G RM R
Sbjct: 1158 QDCELPSCHPPP--AAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGS 1215
Query: 1248 MPTQGEGRPCPTELTQEKTCPVTPCYSWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSG- 1306
+ + P + +E+ C VTPC W +WS+C + CG+G R + C+ +S
Sbjct: 1216 VADESACATLPRPVAKEE-CSVTPCGQWKALDWSSCSV---TCGQGRATRQVMCVNYSDH 1271
Query: 1307 -------------------SISHAAGRVEDALCGEMPFQDSILKQLCSVPCPGDCHLTEW 1347
S+S R D+ + PFQ+ + + P H+
Sbjct: 1272 VIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSA--SPSRTHVLGG 1329
Query: 1348 SEWST-----CELTCIDGRSFETVGRQSRSRTFIIQSFEN---QDSCPQQVL--ETRPCT 1397
++W T C TC G S+ R + Q EN + C +++ E R C
Sbjct: 1330 NQWRTGPWGACSSTCAGG---------SQRRVVVCQD-ENGYTANDCVERIKPDEQRACE 1379
Query: 1398 GGKCYHYTWKASLWNN---------NERTVWCQRSDGVNVTG-GCSPQARPAAIRQC-IP 1446
G C W W R V CQRS+G C +P QC
Sbjct: 1380 SGPCPQ--WAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTH 1437
Query: 1447 AC-------RKPFSYCTQGGVCGCEKGYTEIMKSNGFLDYCMKVPGSEDKKADVKNLS 1497
AC P+S C+ C +G+ + YCM GS + K+L+
Sbjct: 1438 ACPHDAAWSTGPWSSCS----VSCGRGHKQRNV------YCMAKDGSHLESDYCKHLA 1485
Score = 110 bits (275), Expect = 1e-23
Identities = 192/838 (22%), Positives = 283/838 (33%), Gaps = 201/838 (23%)
Query: 18 WGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFRVCDWHSDLFQWEV 77
W C+ C GG Q R C + S C + +R C QW+
Sbjct: 1006 WTECSKSCD-GGTQRRRAICVNTRNDVLDDSKCTHQEKVTIQRCSEFPCP------QWKS 1058
Query: 78 SDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHFALQPPT 137
DW C+ VT G +HR V C + + + +C+ +P +
Sbjct: 1059 GDWSECL----------------VTCGKGHKHRQVWC--QFGEDRLNDRMCDP-ETKPTS 1099
Query: 138 EQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQ------CPNLTE 191
Q C P +C + PW CS CG+ Q R I + T+
Sbjct: 1100 MQTCQQP---ECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTD 1156
Query: 192 SRACDAPISC---PLGEE--EYTFSL-----KVGPWSKC--------RLPHLKEINPSGR 233
++ C+ P SC P E T+S + G W+ C R+ ++ + +G
Sbjct: 1157 TQDCELP-SCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGS 1215
Query: 234 TVLDFNSDSNERVTFKHQ-------SYKAHHHSK-SWAIEIGYQTRQVSCTRSDGQNAML 285
+ + R K + +KA S S G TRQV C
Sbjct: 1216 VADESACATLPRPVAKEECSVTPCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDR 1275
Query: 286 SLCLQDSFPLTVQSCIM-----------------------PKDCETS--------QWSS- 313
S C QD P T Q C M P+ S QW +
Sbjct: 1276 SECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTG 1335
Query: 314 -WSPCSKTCRSGSLLPGFRSRSRNVKHMAIGG--GKECPELLEKEACIVEGELLQQCPRY 370
W CS TC G S+ R V G +C E ++ + E + P
Sbjct: 1336 PWGACSSTCAGG-------SQRRVVVCQDENGYTANDCVERIKPD----EQRACESGPCP 1384
Query: 371 SWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQS-VPAAAALRAKEVSRP 429
W W EC +CGGGI+TR V C +S L + + +P
Sbjct: 1385 QWAYGNWGECT----------------KLCGGGIRTRLVVCQRSNGERFPDLSCEILDKP 1428
Query: 430 VEKALCVGPAPLPSQLCNIPCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLME 489
++ C A C D +AW +C G +G + R + + +
Sbjct: 1429 PDREQCNTHA----------CPHD------AAWSTGPWSSCSVSCG-RGHKQRNVYCMAK 1471
Query: 490 --STGPAGHCPHLVE---SVPCEDPMCYRWLASEGICFPDHGKCGLGHRILKAVCQNDRG 544
S + +C HL + C C +W A G CG G + CQ
Sbjct: 1472 DGSHLESDYCKHLAKPHGHRKCRGGRCPKWKA--GAWSQCSVSCGRGVQQRHVGCQIGTH 1529
Query: 545 EDVSGSLC-PVPPPPERKSCEIPCRMDCVLSEW--TEWSSCSQSCSNKNSDGKQTRSRTI 601
+ + C P P + C+ P C L W EW C+++C G+ +R R +
Sbjct: 1530 KIARETECNPYTRPESERDCQGP---RCPLYTWRAEEWQECTKTC------GEGSRYRKV 1580
Query: 602 LALAGE----GGKPCPPSQALQEHRLCNDHSCMQLHWETSPWGPCSEDTLVTALNATIGW 657
+ + G C S+ + C+ C + W T W CS
Sbjct: 1581 VCVDDNKNEVHGARCDVSKRPVDRESCSLQPC-EYVWITGEWSECS-------------- 1625
Query: 658 NGEATCGVGIQTRRVFCVKSHVGQ-------VMTKRCPDSTRPETVRPCFLPCKKDCIVT 710
TCG G + R V C + + G+ T CP T+P +V PC+L +DC V+
Sbjct: 1626 ---VTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCP-GTQPPSVHPCYL---RDCPVS 1678
Query: 711 A---FSEWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQECPDTLYEERE-CEDVSLC 764
A W C C G V Q + + E D EER+ C +V C
Sbjct: 1679 ATWRVGNWGSCSVSCGVG---VMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVYNC 1733
Score = 85.5 bits (210), Expect = 4e-16
Identities = 106/452 (23%), Positives = 161/452 (35%), Gaps = 91/452 (20%)
Query: 16 GPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFRVCDWHSDLFQW 75
GPWG C+ C GG Q R V C +G+T++ +C E +P ++R+C QW
Sbjct: 1335 GPWGACSSTCA-GGSQRRVVVCQDENGYTAN--DCVERIKPDEQRACES-----GPCPQW 1386
Query: 76 EVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHFALQP 135
+W C + G++ R+V C Q+ N + CE P
Sbjct: 1387 AYGNWGECTKL----------------CGGGIRTRLVVC-QRSNGERFPDLSCEILDKPP 1429
Query: 136 PTEQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFG------------- 182
EQ CP D S PWS+CS CG+ H+ R V G
Sbjct: 1430 DREQCNTHACPHDAAWSTG-PWSSCSVSCGR--GHKQRNVYCMAKDGSHLESDYCKHLAK 1486
Query: 183 --------GLQCPNLTESRACDAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGRT 234
G +CP +SC G ++ ++G ++ E NP R
Sbjct: 1487 PHGHRKCRGGRCPKWKAGAWSQCSVSCGRGVQQRHVGCQIGTH---KIARETECNPYTRP 1543
Query: 235 VLDFNSDSNERVTFKHQSYKAHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFP 294
+ + + ++ + +K+ G + R+V C + + C P
Sbjct: 1544 ESERDCQGPRCPLYTWRAEEWQECTKTCG--EGSRYRKVVCVDDNKNEVHGARCDVSKRP 1601
Query: 295 LTVQSCIMPKDCETSQW--SSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELL 352
+ +SC + + CE W WS CS TC G + R V I GKE E
Sbjct: 1602 VDRESCSL-QPCE-YVWITGEWSECSVTCGKG-------YKQRLVSCSEIYTGKENYEYS 1652
Query: 353 EKEACIVEGE--------LLQQCP-RYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGG 403
+ G L+ CP +WR W C VS CG G
Sbjct: 1653 YQTTINCPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVS----------------CGVG 1696
Query: 404 IQTREVYCAQSVPAAAALRAKEVSRPVEKALC 435
+ R V C + + L ++ +P E+ C
Sbjct: 1697 VMQRSVQCLTNEDQPSHLCHTDL-KPEERKTC 1727
Score = 58.9 bits (141), Expect = 4e-08
Identities = 52/213 (24%), Positives = 76/213 (35%), Gaps = 33/213 (15%)
Query: 15 AGPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFRVCDWHSDLFQ 74
AG W +C+ CG GVQ R V C + + C RP ER C L+
Sbjct: 1503 AGAWSQCSVSCG-RGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGP---RCPLYT 1558
Query: 75 WEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHFALQ 134
W +W C T G ++R V C+ N+ V C+
Sbjct: 1559 WRAEEWQECT----------------KTCGEGSRYRKVVCVDD-NKNEVHGARCDVSKRP 1601
Query: 135 PPTEQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPNLTESRA 194
E L PC + E WS CS CGK ++ R V ++ G + +
Sbjct: 1602 VDRESCSLQPCEYVWITGE---WSECSVTCGK--GYKQRLVSCSEIYTGKENYEYSYQTT 1656
Query: 195 CDAPIS-------CPLGEEEYTFSLKVGPWSKC 220
+ P + C L + + + +VG W C
Sbjct: 1657 INCPGTQPPSVHPCYLRDCPVSATWRVGNWGSC 1689
Score = 50.1 bits (118), Expect = 2e-05
Identities = 46/171 (26%), Positives = 61/171 (35%), Gaps = 33/171 (19%)
Query: 10 LYHKLAGPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSC-FRVCDW 68
LY A W CT CG G + R V C + H + C S RP SC + C+
Sbjct: 1556 LYTWRAEEWQECTKTCGEGS-RYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCE- 1613
Query: 69 HSDLFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQ----KLNRTVVA 124
+ W +W C VT G + R+V C + K N
Sbjct: 1614 ----YVWITGEWSEC----------------SVTCGKGYKQRLVSCSEIYTGKENYEYSY 1653
Query: 125 NEICEHFALQPPTEQACLIPCPRDCVVS---EFLPWSNCSKGCGKKLQHRT 172
QPP+ C + RDC VS W +CS CG + R+
Sbjct: 1654 QTTINCPGTQPPSVHPCYL---RDCPVSATWRVGNWGSCSVSCGVGVMQRS 1701
Score = 36.6 bits (83), Expect = 0.20
Identities = 37/147 (25%), Positives = 63/147 (42%), Gaps = 37/147 (25%)
Query: 894 EFISQPYGNWSDCILPEGRREPHRGLRVQAD------SKEC----GEG-------LRFRA 936
EF+ YG +C+L E P+ L VQ +K+C G G ++ R
Sbjct: 485 EFLDTGYG---ECLLNEPESRPYP-LPVQLPGILYNVNKQCELIFGPGSQVCPYMMQCRR 540
Query: 937 VACSDKNGRP----------VDPSFCSSSGYIQEKCVIPCPFDCKLSD-----WSSWGSC 981
+ C++ NG D + C + + +P D ++D WS +G+C
Sbjct: 541 LWCNNVNGVHKGCRTQHTPWADGTECEPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTC 600
Query: 982 SSSCGIGVRIRSKWL-KEKPYNGGRPC 1007
S +CG G++ + + +P NGG+ C
Sbjct: 601 SRTCGGGIKTAIRECNRPEPKNGGKYC 627
Score = 31.2 bits (69), Expect = 8.3
Identities = 21/88 (23%), Positives = 33/88 (37%), Gaps = 11/88 (12%)
Query: 1185 CSDGKPVSMDQCEQHNLEKPQRMSIPCLVECVVNCQLSGWTAWTECSQTCGHGGRMSRTR 1244
C GK C P+ M +P V + W+ + CS+TCG G + +
Sbjct: 566 CEPGKHCKYGFCV------PKEMDVP-----VTDGSWGSWSPFGTCSRTCGGGIKTAIRE 614
Query: 1245 FIIMPTQGEGRPCPTELTQEKTCPVTPC 1272
+ G+ C + K+C PC
Sbjct: 615 CNRPEPKNGGKYCVGRRMKFKSCNTEPC 642
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 163 bits (412), Expect = 1e-39
Identities = 227/972 (23%), Positives = 357/972 (36%), Gaps = 203/972 (20%)
Query: 432 KALCVGPAPLPS--QLCNIPCSTDCIVSSWSAWGLCIHENCHDP-QGKKGFRTRQRHVLM 488
+ LCVG P NIP + +W +G E C QG + H
Sbjct: 821 QVLCVGNLYNPDVHYSFNIPLEERSDMFTWDPYGPW--EGCTKMCQGLQRRNITCIHKSD 878
Query: 489 ESTGPAGHCPHL----VESVPCEDPMCYRW-LASEGICFPDHGKCGLGHRILKAVCQN-- 541
S C HL + C RW + + C +CG G+R L C
Sbjct: 879 HSVVSDKECDHLPLPSFVTQSCNTDCELRWHVIGKSEC---SSQCGQGYRTLDIHCMKYS 935
Query: 542 ---DRGEDVSGSLC--PVPPPPERKSCEIPCRMDCVLSEW--TEWSSCSQSCSNKNSDGK 594
+ V C + PP + C +CV + W +EWS CS+SC G+
Sbjct: 936 IHEGQTVQVDDHYCGDQLKPPTQEL-----CHGNCVFTRWHYSEWSQCSRSCGG----GE 986
Query: 595 QTRSRTILALAGE--GGKPCPP-SQALQEHRLCNDHSCMQLHWETSPWGPCSEDTLVTAL 651
++R + G C S+ +E+ CN+ SC W S W C
Sbjct: 987 RSRESYCMNNFGHRLADNECQELSRVTREN--CNEFSCPS--WAASEWSECL-------- 1034
Query: 652 NATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPETVRPCFLPCKKDCIVTA 711
TCG G + R+V+C + +V + C ST+PE++ PC L C
Sbjct: 1035 ---------VTCGKGTKQRQVWC-QLNVDHLSDGFCNSSTKPESLSPCEL---HTCASWQ 1081
Query: 712 FSEWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQECPDTLYEERECEDVSLCPVYRWKP 771
W PC C G Y++ + N E + E+ EC + S +P
Sbjct: 1082 VGPWGPCTTTCGHG--------YQMRDVKCVN---ELASAVLEDTECHEAS-------RP 1123
Query: 772 QKWSPCILVPESV-------------------WQ--GITGSSEACGKGLQTRAVSCISDD 810
C+L P S W+ T S +CG+G Q R VSC
Sbjct: 1124 SDRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDAL 1183
Query: 811 NRSAEMMECLKQTNGMPLLVQECTVPCREDCTFTAWSK--FTPCSTNCEATKSRRRQLTG 868
+R A+ C P + +C PC E W ++PCS +C K+ R+ L
Sbjct: 1184 DRIADESYCAHLPR--PAEIWDCFTPCGE------WQAGDWSPCSASCGHGKTTRQVLCM 1235
Query: 869 KSRKK--EKCQDSDLYPLVETEL----CPC--DEFISQPY-----------------GNW 903
+ E D ++ PL+E E CP F S P N
Sbjct: 1236 NYHQPIDENYCDPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNE 1295
Query: 904 SDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSDKNGRPVDPSFCSSSGYIQEKCV 963
+ + P R R + S C GL+ RAV C D+NG+ S+C ++ E +
Sbjct: 1296 NQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSA--SYCDAASKPPE--L 1351
Query: 964 IPC-PFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHEAV 1022
C P C ++ +WG CS +CG G++ R + P ++ + ++
Sbjct: 1352 QQCGPGPCPQWNYGNWGECSQTCGGGIKSRLVICQ-------FPNGQILEDHNCEIVNKP 1404
Query: 1023 PCYSECNQY------SWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDS 1076
P +C+ + SW E W+SC S CG G + R++ C++ + ++
Sbjct: 1405 PSVIQCHMHACPADVSWHQEPWTSC-------SASCGKGRKYREVFCIDQFQRK---LED 1454
Query: 1077 NLCNQDEIPPETQSC-SLMCPNECVMSEWGLWSKCPQSCDPHTMQRRTRHLLR--PSLNS 1133
C+Q + PP ++C S+ CP+ S W++C +C QR L+ +
Sbjct: 1455 TNCSQVQKPPTHKACRSVRCPSWKANS----WNECSVTCGSGVQQRDVYCRLKGVGQVVE 1510
Query: 1134 RTCAEDSQVQPC----LLNENCFQFQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSDGK 1189
C D +PC +++C Q + C S C + + + C + +
Sbjct: 1511 EMC--DQSTRPCSQRRCWSQDCVQHKGMERGRLNCSTS----CERKDSHQRMECTDNQIR 1564
Query: 1190 PVS--MDQCEQHNLEKPQRMSIPCLVECVVNCQLSGWTAWTECSQTCGHGGRMSRTRFII 1247
V+ + +L + PC VV S +C+ CG R T
Sbjct: 1565 QVNEIVYNSSTISLTSKNCRNPPCNY-IVVTADSS------QCANNCGFSYRQRITYCTE 1617
Query: 1248 MPTQGEGRPCPTELTQEKTCPVTP-------------CYSWVLGNWSACKLEGGDCGEGV 1294
+P+ + + + CPV P +W +G WS C + CG G+
Sbjct: 1618 IPSTKKHKLHRLRPIVYQECPVVPSSQVYQCINSCLHLATWKVGKWSKCSV---TCGIGI 1674
Query: 1295 QIRSLSCMVHSG 1306
R + C+ G
Sbjct: 1675 MKRQVKCITKHG 1686
Score = 120 bits (301), Expect = 1e-26
Identities = 192/791 (24%), Positives = 280/791 (35%), Gaps = 165/791 (20%)
Query: 657 WNGEATCGVGIQTRRVFCV-KSHVGQVMTKRCPDSTRPETV-RPCFLPCKKDCIVTAFSE 714
W G G+Q R + C+ KS V K C P V + C C+ V SE
Sbjct: 856 WEGCTKMCQGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTDCELRWHVIGKSE 915
Query: 715 WTPCPRMCQAGNATVKQSRYRIIIQEAAN---GGQECPDTLYEERECEDVSLCPVYRWKP 771
C C G T+ + I E C D L + C RW
Sbjct: 916 ---CSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNCVFTRWHY 972
Query: 772 QKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCISDDNRSAEMMECLKQTNGMPLLVQ 831
+WS C S +CG G ++R C+++ EC Q
Sbjct: 973 SEWSQC--------------SRSCGGGERSRESYCMNNFGHRLADNEC-----------Q 1007
Query: 832 ECTVPCREDC---TFTAW--SKFTPCSTNC-EATKSRRR--QLTGKSRKKEKCQDSDLYP 883
E + RE+C + +W S+++ C C + TK R+ QL C S
Sbjct: 1008 ELSRVTRENCNEFSCPSWAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTK-- 1065
Query: 884 LVETELCPCD--EFISQPYGNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSD 941
L PC+ S G W C + CG G + R V C +
Sbjct: 1066 --PESLSPCELHTCASWQVGPWGPC------------------TTTCGHGYQMRDVKCVN 1105
Query: 942 KNGRPV-DPSFC--SSSGYIQEKCVI-PCPFDCKL-------------SDW--SSWGSCS 982
+ V + + C +S ++ CV+ PC F KL + W SW CS
Sbjct: 1106 ELASAVLEDTECHEASRPSDRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCS 1165
Query: 983 SSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHEAVPCYSECNQYSWVVEHWSSCK 1042
SCG G + R ++ L A++ + C++ C + W WS C
Sbjct: 1166 VSCGRGTQARYVSCRDALDRIADESYCAHLPRPAEIWD---CFTPCGE--WQAGDWSPC- 1219
Query: 1043 INNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQSCSLM-CPNECVM 1101
S CG G +R++ C+N +D N C+ + P Q CSL CP
Sbjct: 1220 ------SASCGHGKTTRQVLCMNYHQ----PIDENYCDPEVRPLMEQECSLAACPPA--- 1266
Query: 1102 SEWGLWSKCPQSCDPHTMQRRTRHLLRPSLNSRTCAEDSQVQPCLLNENCFQFQYNLTEW 1161
S P S + T L L E+ V P + Q+ W
Sbjct: 1267 -----HSHFPSSPVQPSYYLSTNLPLTQKLEDN---ENQVVHPSVRGN-----QWRTGPW 1313
Query: 1162 STCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHNLEKPQRMSIPCLVECVVN-CQ 1220
+C S C G++ R + VC D S C+ + KP P L +C C
Sbjct: 1314 GSCSSS----CSGGLQHRAV--VCQDENGQSASYCDAAS--KP-----PELQQCGPGPCP 1360
Query: 1221 LSGWTAWTECSQTCGHGGRMSRTRFIIMPTQG--EGRPC-----PTELTQ--EKTCPVTP 1271
+ W ECSQTCG GG SR P E C P + Q CP
Sbjct: 1361 QWNYGNWGECSQTCG-GGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPAD- 1418
Query: 1272 CYSWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSILK 1331
SW W++C CG+G + R + C I ++ED C ++ + K
Sbjct: 1419 -VSWHQEPWTSC---SASCGKGRKYREVFC------IDQFQRKLEDTNCSQVQ-KPPTHK 1467
Query: 1332 QLCSVPCPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQSFENQDSCPQQVL 1391
SV CP + + W+ C +TC G V + + ++ ++ C Q
Sbjct: 1468 ACRSVRCPS----WKANSWNECSVTCGSGVQQRDVYCRLKGVGQVV-----EEMCDQ--- 1515
Query: 1392 ETRPCTGGKCY 1402
TRPC+ +C+
Sbjct: 1516 STRPCSQRRCW 1526
Score = 116 bits (291), Expect = 1e-25
Identities = 229/1003 (22%), Positives = 336/1003 (33%), Gaps = 238/1003 (23%)
Query: 70 SDLFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICE 129
SD+F W+ PY E C GLQ R + CI K + +VV+++ C+
Sbjct: 845 SDMFTWD----------PYGPWE------GCTKMCQGLQRRNITCIHKSDHSVVSDKECD 888
Query: 130 HFALQPPTEQACLIPCP-RDCVVSEFLPWSNCSKG-------CGKKLQHRTRAVIAPPLF 181
H L Q+C C R V+ + S C +G C K H + V +
Sbjct: 889 HLPLPSFVTQSCNTDCELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHY 948
Query: 182 GGLQCPNLTESRACDAPISCPLGEEEYTFSLKVGPWSKC--------RLPHLKEINPSGR 233
G Q T+ C +C Y+ WS+C R +N G
Sbjct: 949 CGDQLKPPTQE-LCHG--NCVFTRWHYS------EWSQCSRSCGGGERSRESYCMNNFGH 999
Query: 234 TVLDFNSDSNERVT------FKHQSYKAHHHSKSWAI-EIGYQTRQVSCTR-----SDGQ 281
+ D RVT F S+ A S+ G + RQV C SDG
Sbjct: 1000 RLADNECQELSRVTRENCNEFSCPSWAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDG- 1058
Query: 282 NAMLSLCLQDSFPLTVQSCIMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMA 341
C + P ++ C + C + Q W PC+ TC G + + N A
Sbjct: 1059 -----FCNSSTKPESLSPCEL-HTCASWQVGPWGPCTTTCGHGYQMRDVKCV--NELASA 1110
Query: 342 IGGGKECPELL---EKEACIV---------EGELLQQC---PRYSWRTSEWKECQVSLLL 386
+ EC E ++++C++ E LL WR W C VS
Sbjct: 1111 VLEDTECHEASRPSDRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVS--- 1167
Query: 387 EQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAA-ALRAKEVSRPVEKALCVGPAPLPSQL 445
CG G Q R V C ++ A + RP E C P
Sbjct: 1168 -------------CGRGTQARYVSCRDALDRIADESYCAHLPRPAEIWDCFTPCGEWQAG 1214
Query: 446 CNIPCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVESVP 505
PCS C + LC+ N H P + + + LME CP P
Sbjct: 1215 DWSPCSASCGHGKTTRQVLCM--NYHQPIDEN-YCDPEVRPLMEQECSLAACPPAHSHFP 1271
Query: 506 CEDPMCYRWLASE------------GICFPD----------HGKC------GLGHRILKA 537
+L++ + P G C GL HR +
Sbjct: 1272 SSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAV-- 1329
Query: 538 VCQNDRGEDVSGSLCPVPP-PPERKSCEI-PCRMDCVLSEWT--EWSSCSQSCSNKNSDG 593
VCQ++ G+ S S C PPE + C PC +W W CSQ+C G
Sbjct: 1330 VCQDENGQ--SASYCDAASKPPELQQCGPGPC------PQWNYGNWGECSQTC------G 1375
Query: 594 KQTRSRTILALAGEGGKPCPPSQALQEHRL-----------CNDHSC-MQLHWETSPWGP 641
+SR ++ P Q L++H C+ H+C + W PW
Sbjct: 1376 GGIKSRLVIC-------QFPNGQILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTS 1428
Query: 642 CSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPETVRPCFL 701
CS A+CG G + R VFC+ ++ C +P T + C
Sbjct: 1429 CS-----------------ASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACR- 1470
Query: 702 PCKKDCIVTAFSEWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQECPDTLYEERECEDV 761
C + W C C +G V+Q R + GQ + EE +
Sbjct: 1471 --SVRCPSWKANSWNECSVTCGSG---VQQ---RDVYCRLKGVGQ-----VVEEMCDQST 1517
Query: 762 SLCPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCISDDNRSAEMMECLK 821
C R WS + + + +G S +C + + + C DN+ ++ E +
Sbjct: 1518 RPCSQRRC----WSQDCVQHKGMERGRLNCSTSCERKDSHQRMECT--DNQIRQVNEIVY 1571
Query: 822 QTNGMPLLVQECTVPCREDCTFTAWSKFTPCSTNCEATKSRRRQLTGKSRKKEKCQDSDL 881
++ + L + C P TA S + C+ NC + +R + +K + L
Sbjct: 1572 NSSTISLTSKNCRNPPCNYIVVTADS--SQCANNCGFSYRQRITYCTEIPSTKKHKLHRL 1629
Query: 882 YPLVETELCP-------------CDEFISQPYGNWSDCILPEGRREPHRGLRVQADSKEC 928
P+V E CP C + G WS C S C
Sbjct: 1630 RPIVYQE-CPVVPSSQVYQCINSCLHLATWKVGKWSKC------------------SVTC 1670
Query: 929 GEGLRFRAVACSDKNGRPVDPSFCSSSGYIQEKCVIPCPFDCK 971
G G+ R V C K+G D Q+KC DCK
Sbjct: 1671 GIGIMKRQVKCITKHGLSSDLCLNHLKPGAQKKCYAN---DCK 1710
Score = 116 bits (291), Expect = 1e-25
Identities = 211/928 (22%), Positives = 321/928 (34%), Gaps = 249/928 (26%)
Query: 267 GYQTRQVSCTR---SDGQNAMLS--LCLQDSFPLTVQSCIMPKDCETSQW--SSWSPCSK 319
GY+T + C + +GQ + C P T + C +C ++W S WS CS+
Sbjct: 923 GYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELC--HGNCVFTRWHYSEWSQCSR 980
Query: 320 TCRSGSLLPGFRSRS----RNVKHMAIGGGKECPEL--LEKEACIVEGELLQQCPRYSWR 373
+C G RSR N H EC EL + +E C E CP SW
Sbjct: 981 SCGGGE-----RSRESYCMNNFGHRL--ADNECQELSRVTRENC---NEF--SCP--SWA 1026
Query: 374 TSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKA 433
SEW EC V+ CG G + R+V+C +V + ++P +
Sbjct: 1027 ASEWSECLVT----------------CGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLS 1070
Query: 434 LC---------VGPAPLPSQLCNIPCSTDCIVSSWSAWGLCIHE---------NCHDPQG 475
C VGP PC+T C C++E CH+
Sbjct: 1071 PCELHTCASWQVGPWG--------PCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASR 1122
Query: 476 KKGFRTRQRHVLMESTGPAGHCPHLVESVPCEDPMCYRWLASEGICFPDHGKCGLGHRIL 535
RQ VL + + L+ +V + +R G P CG G +
Sbjct: 1123 PSD---RQSCVLTPCSFISKLETALLPTVLIKKMAQWR----HGSWTPCSVSCGRGTQAR 1175
Query: 536 KAVCQNDRGEDVSGSLCP-VPPPPERKSCEIPCRMDCVLSEWT--EWSSCSQSCSNKNSD 592
C++ S C +P P E C PC EW +WS CS SC +
Sbjct: 1176 YVSCRDALDRIADESYCAHLPRPAEIWDCFTPC------GEWQAGDWSPCSASCGH---- 1225
Query: 593 GKQTRSRTIL------------------------------ALAGEGGKPCPPSQALQEH- 621
GK TR + A + P PS L +
Sbjct: 1226 GKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNL 1285
Query: 622 ---RLCNDHSCMQLH-------WETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRR 671
+ D+ +H W T PWG CS ++C G+Q R
Sbjct: 1286 PLTQKLEDNENQVVHPSVRGNQWRTGPWGSCS-----------------SSCSGGLQHRA 1328
Query: 672 VFCVKSHVGQVMTKRCPDSTRPETVRPCFL-PCKKDCIVTAFSEWTPCPRMCQAGNATVK 730
V C + GQ C +++P ++ C PC + + W C + C G
Sbjct: 1329 VVCQDEN-GQ-SASYCDAASKPPELQQCGPGPCPQ----WNYGNWGECSQTCGGG----- 1377
Query: 731 QSRYRIIIQEAANGGQECPDTLYEERECEDVS-----------LCPV-YRWKPQKWSPCI 778
+ R++I + NG + E+ CE V+ CP W + W+ C
Sbjct: 1378 -IKSRLVICQFPNG------QILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSC- 1429
Query: 779 LVPESVWQGITGSSEACGKGLQTRAVSCISDDNRSAEMMECLKQTNGMPLLVQECTVPCR 838
S +CGKG + R V CI R E C Q P +V C
Sbjct: 1430 -------------SASCGKGRKYREVFCIDQFQRKLEDTNC-SQVQKPPTHKACRSVRC- 1474
Query: 839 EDCTFTAW--SKFTPCSTNCEATKSRRRQLTGKSRKKEKCQDSDLYPLVETELCPCDEFI 896
+W + + CS C + G ++ C+ + +VE E+C
Sbjct: 1475 -----PSWKANSWNECSVTCGS---------GVQQRDVYCRLKGVGQVVE-EMCDQSTRP 1519
Query: 897 SQPYGNWS-DCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSDKNGRPVDPSFCSSS 955
WS DC+ +G + K+ + + C+D R V+ +SS
Sbjct: 1520 CSQRRCWSQDCVQHKGMERGRLNCSTSCERKDSHQRME-----CTDNQIRQVNEIVYNSS 1574
Query: 956 --GYIQEKCVIP-CPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKL-- 1010
+ C P C + +D S C+++CG R R + E P +L
Sbjct: 1575 TISLTSKNCRNPPCNYIVVTADSSQ---CANNCGFSYRQRITYCTEIPSTKKHKLHRLRP 1631
Query: 1011 ------DLKNQAQVHEAVPCYSEC-NQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRC 1063
+ +QV++ C + C + +W V WS C S+ CG G R+++C
Sbjct: 1632 IVYQECPVVPSSQVYQ---CINSCLHLATWKVGKWSKC-------SVTCGIGIMKRQVKC 1681
Query: 1064 VNTADGEGGAVDSNLCNQDEIPPETQSC 1091
+ T G + S+LC P + C
Sbjct: 1682 I-TKHG----LSSDLCLNHLKPGAQKKC 1704
Score = 98.2 bits (243), Expect = 6e-20
Identities = 190/867 (21%), Positives = 290/867 (33%), Gaps = 235/867 (27%)
Query: 440 PLPSQLCNIPCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPH 499
PLPS + C+TDC + W + C G+ G+RT H + S H
Sbjct: 891 PLPSFVTQ-SCNTDCELR----WHVIGKSECSSQCGQ-GYRTLDIHCMKYSI-------H 937
Query: 500 LVESVPCEDPMCYRWLA--SEGICFPDHGKC-----------------GLGHRILKAVCQ 540
++V +D C L ++ +C HG C G G R ++ C
Sbjct: 938 EGQTVQVDDHYCGDQLKPPTQELC---HGNCVFTRWHYSEWSQCSRSCGGGERSRESYCM 994
Query: 541 NDRGEDVSGSLCPVPPPPERKSCEIPCRMDCVLSEWTEWSSCSQSCSNKNSDGKQTRSRT 600
N+ G ++ + C R++C C +EWS C +C GK T+ R
Sbjct: 995 NNFGHRLADNECQELSRVTRENCN---EFSCPSWAASEWSECLVTC------GKGTKQRQ 1045
Query: 601 I---LALAGEGGKPCPPSQALQEHRLCNDHSCMQLHWETSPWGPCS-------------- 643
+ L + C S + C H+C W+ PWGPC+
Sbjct: 1046 VWCQLNVDHLSDGFCNSSTKPESLSPCELHTCAS--WQVGPWGPCTTTCGHGYQMRDVKC 1103
Query: 644 ---------EDT------------------------LVTALNATI-----------GWNG 659
EDT L TAL T+ W
Sbjct: 1104 VNELASAVLEDTECHEASRPSDRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTP 1163
Query: 660 -EATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPETVRPCFLPCKKDCIVTAFSEWTPC 718
+CG G Q R V C + C RP + CF PC + +W+PC
Sbjct: 1164 CSVSCGRGTQARYVSCRDALDRIADESYCAHLPRPAEIWDCFTPCGE----WQAGDWSPC 1219
Query: 719 PRMCQAGNAT--VKQSRYRIIIQEAANGGQECPDTLYEERECEDVSLCPVYRWKPQK-WS 775
C G T V Y I E + P E+EC + P + P
Sbjct: 1220 SASCGHGKTTRQVLCMNYHQPIDENYCDPEVRP---LMEQECSLAACPPAHSHFPSSPVQ 1276
Query: 776 PCILVPESV----------------------WQ-GITGS-SEACGKGLQTRAVSCISDDN 811
P + ++ W+ G GS S +C GLQ RAV C ++
Sbjct: 1277 PSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQDENG 1336
Query: 812 RSAEMMECLKQTNGMPLLVQECTV-PCREDCTFTAWSKFTPCSTNCEATKSRRRQL---- 866
+SA + + P +Q+C PC + + W + CS C R +
Sbjct: 1337 QSASYCDAASK----PPELQQCGPGPCPQ-WNYGNWGE---CSQTCGGGIKSRLVICQFP 1388
Query: 867 TGKSRKKEKCQDSDLYPLV---ETELCPCDEFISQPYGNWSDCILPEGRREPHRGLRVQA 923
G+ + C+ + P V CP D +S W+ C
Sbjct: 1389 NGQILEDHNCEIVNKPPSVIQCHMHACPAD--VSWHQEPWTSC----------------- 1429
Query: 924 DSKECGEGLRFRAVACSDKNGRPVDPSFCSSSGYIQEKCVIPCPFDCKLSDW--SSWGSC 981
S CG+G ++R V C D+ R ++ + CS +Q+ + W +SW C
Sbjct: 1430 -SASCGKGRKYREVFCIDQFQRKLEDTNCSQ---VQKPPTHKACRSVRCPSWKANSWNEC 1485
Query: 982 SSSCGIGVRIRSKWLKEKPYN---------GGRPCPKLDLKNQAQVHEA------VPCYS 1026
S +CG GV+ R + + K RPC + +Q V + C +
Sbjct: 1486 SVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGMERGRLNCST 1545
Query: 1027 EC-------------NQYSWVVEH-WSSCKINNELRSLR-------------------CG 1053
C NQ V E ++S I+ ++ R CG
Sbjct: 1546 SCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVTADSSQCANNCG 1605
Query: 1054 GGTQSRKIRCVNTADGEGGAVDS-NLCNQDEIPPETQSCSLMCPNECV-MSEW--GLWSK 1109
+ R C + + E P S C N C+ ++ W G WSK
Sbjct: 1606 FSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQCINSCLHLATWKVGKWSK 1665
Query: 1110 CPQSCDPHTMQRRTRHLLRPSLNSRTC 1136
C +C M+R+ + + + L+S C
Sbjct: 1666 CSVTCGIGIMKRQVKCITKHGLSSDLC 1692
Score = 86.3 bits (212), Expect = 2e-16
Identities = 176/777 (22%), Positives = 258/777 (33%), Gaps = 177/777 (22%)
Query: 16 GPWGRCTGDCGPGGVQSRAVWCFH-VDGWTSHLSNCGESNRPPKERSCFRV-CDWHSDL- 72
GPWG CT CG G Q R V C + + + C E++RP +SC C + S L
Sbjct: 1083 GPWGPCTTTCGHG-YQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFISKLE 1141
Query: 73 ------------FQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNR 120
QW W C V+ G Q R V C L+R
Sbjct: 1142 TALLPTVLIKKMAQWRHGSWTPC----------------SVSCGRGTQARYVSCRDALDR 1185
Query: 121 TVVANEICEHFALQPPTEQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPL 180
+ C H +P C PC + WS CS CG TR V+
Sbjct: 1186 -IADESYCAHLP-RPAEIWDCFTPCGE----WQAGDWSPCSASCGHG--KTTRQVLC--- 1234
Query: 181 FGGLQCPNLTESRACDAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPS----GRTVL 236
+ + CD + PL E+E SL P + P + PS L
Sbjct: 1235 ---MNYHQPIDENYCDPEVR-PLMEQEC--SLAACPPAHSHFPS-SPVQPSYYLSTNLPL 1287
Query: 237 DFNSDSNERVTFKHQSYKAHHH------SKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQ 290
+ NE H S + + S S + G Q R V C +GQ+A S C
Sbjct: 1288 TQKLEDNENQVV-HPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSA--SYCDA 1344
Query: 291 DSFPLTVQSCIMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGG----GK 346
S P +Q C P C + +W CS+TC G +SR V G
Sbjct: 1345 ASKPPELQQC-GPGPCPQWNYGNWGECSQTCGGGI-------KSRLVICQFPNGQILEDH 1396
Query: 347 ECPELLEKEACIVEGELLQQCPR-YSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQ 405
C E++ K +++ + CP SW W C S CG G +
Sbjct: 1397 NC-EIVNKPPSVIQCHM-HACPADVSWHQEPWTSCSAS----------------CGKGRK 1438
Query: 406 TREVYCAQSVPAAAALRAKEVSRPVEKALCVGPAPLPSQLCNIPCSTDCIVSSWSAWGLC 465
REV+C + R +E C SQ+ P C +W
Sbjct: 1439 YREVFCID-----------QFQRKLEDTNC-------SQVQKPPTHKACRSVRCPSWKAN 1480
Query: 466 IHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVESVPCEDPMCYR--WLASEGICFP 523
C G G + R + ++ G + PC C+ + +G+
Sbjct: 1481 SWNECSVTCG-SGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGM--- 1536
Query: 524 DHGKCGLGH------------------RILKAVCQNDRGEDVSGSLCPVPPPP--ERKSC 563
+ G+ R + + N ++ C PP +
Sbjct: 1537 ERGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVTAD 1596
Query: 564 EIPCRMDCVLSEWTEWSSCSQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHRL 623
C +C S + C++ S K K R R I+ + CP + Q ++
Sbjct: 1597 SSQCANNCGFSYRQRITYCTEIPSTKKH--KLHRLRPIVY------QECPVVPSSQVYQC 1648
Query: 624 CNDHSCMQL-HWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQV 682
N SC+ L W+ W CS TCG+GI R+V C+ H +
Sbjct: 1649 IN--SCLHLATWKVGKWSKCS-----------------VTCGIGIMKRQVKCITKH--GL 1687
Query: 683 MTKRCPDSTRPETVRPCFLPCKKDCIVTAFSEWTPCPRMCQAGNATVKQSRYRIIIQ 739
+ C + +P + C+ DC +T C + Q N K Y + I+
Sbjct: 1688 SSDLCLNHLKPGAQKKCY---ANDC-----KSFTTCKEI-QVKNHIRKDGDYYLNIK 1735
Score = 68.6 bits (166), Expect = 5e-11
Identities = 175/777 (22%), Positives = 248/777 (31%), Gaps = 196/777 (25%)
Query: 15 AGPWGRCTGDCGPGGVQSRAVWC-FHVDGWTSHLSN--CGESNRPPKERSCFRVCDWHSD 71
A W C CG G Q R VWC +VD HLS+ C S +P C+ H+
Sbjct: 1027 ASEWSECLVTCGKGTKQ-RQVWCQLNVD----HLSDGFCNSSTKPES----LSPCELHT- 1076
Query: 72 LFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHF 131
W+V W C T HG Q R V+C+ +L V+ + C H
Sbjct: 1077 CASWQVGPWGPCT----------------TTCGHGYQMRDVKCVNELASAVLEDTEC-HE 1119
Query: 132 ALQPPTEQAC-LIPCP-RDCVVSEFLP--------------WSNCSKGCGKKLQHRTRAV 175
A +P Q+C L PC + + LP W+ CS CG+ Q R +
Sbjct: 1120 ASRPSDRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSC 1179
Query: 176 ------IAPPLFGGLQCPNLTESRACDAPISCPLGEEEYTFSLKVGPWSKCRLP--HLKE 227
IA + P E C P + G WS C H K
Sbjct: 1180 RDALDRIADESYCA-HLPRPAEIWDCFTPCG----------EWQAGDWSPCSASCGHGK- 1227
Query: 228 INPSGRTVLDFN---------SDSNERVTFKHQSY-----KAHHHSKSWAIEIGYQTRQV 273
+ R VL N D R + + AH H S ++ Y
Sbjct: 1228 ---TTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYL--- 1281
Query: 274 SCTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSR 333
N L+ L+D+ V + T W S CS +C G
Sbjct: 1282 ------STNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGS---CSSSCSGG--------- 1323
Query: 334 SRNVKHMAIGGGKECPELLEKEACIVEGELLQQC---PRYSWRTSEWKECQVSLLLEQQD 390
++H A+ E + + LQQC P W W EC
Sbjct: 1324 ---LQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCPQWNYGNWGEC---------- 1370
Query: 391 PHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKALCVGPAPLPSQLCNIPC 450
CGGGI++R V C P L V P Q C
Sbjct: 1371 ------SQTCGGGIKSRLVIC--QFPNGQILEDHNCE-------IVNKPPSVIQCHMHAC 1415
Query: 451 STDCIVSSW--SAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVESVP--- 505
D SW W C + ++ F Q +E T +C V+ P
Sbjct: 1416 PADV---SWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDT----NCSQ-VQKPPTHK 1467
Query: 506 -CEDPMCYRWLA-SEGICFPDHGKCGLGHRILKAVCQNDRGEDVSGSLCPVPPPP-ERKS 562
C C W A S C CG G + C+ V +C P ++
Sbjct: 1468 ACRSVRCPSWKANSWNEC---SVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRR 1524
Query: 563 CEIPCRMDCVLSEWTEWS--SCSQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQALQE 620
C DCV + E +CS SC K+S + C +Q Q
Sbjct: 1525 C---WSQDCVQHKGMERGRLNCSTSCERKDSHQRM---------------ECTDNQIRQV 1566
Query: 621 HRLCNDHSCMQLHWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFC-----V 675
+ + + S + L + PC+ +VTA ++ N CG + R +C
Sbjct: 1567 NEIVYNSSTISLTSKNCRNPPCNY-IVVTADSSQCANN----CGFSYRQRITYCTEIPST 1621
Query: 676 KSH----VGQVMTKRCPDSTRPETVRPCFLPCKKDCIVTA---FSEWTPCPRMCQAG 725
K H + ++ + CP + + C C+ A +W+ C C G
Sbjct: 1622 KKHKLHRLRPIVYQECPVVPSSQVYQ-----CINSCLHLATWKVGKWSKCSVTCGIG 1673
Score = 59.3 bits (142), Expect = 3e-08
Identities = 66/266 (24%), Positives = 105/266 (39%), Gaps = 58/266 (21%)
Query: 1227 WTECSQTCGHGGRMSRT------RFIIMPTQGEGRPCPTELTQEKTCPVTPCYSWVLGNW 1280
W C++ C R + T ++ + + P P+ +TQ +C W +
Sbjct: 856 WEGCTKMCQGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQ--SCNTDCELRWHVIGK 913
Query: 1281 SACKLEGGDCGEGVQIRSLSCM---VHSGSISHAAGRVEDALCGEMPFQDSILKQLCSVP 1337
S C + CG+G + + CM +H G +V+D CG+ LK
Sbjct: 914 SECSSQ---CGQGYRTLDIHCMKYSIHEGQTV----QVDDHYCGDQ------LKPPTQEL 960
Query: 1338 CPGDCHLTEW--SEWSTCELTCIDGRSFETVGRQSRSR-TFIIQSFENQ---DSCPQQVL 1391
C G+C T W SEWS C +C G RSR ++ + +F ++ + C +
Sbjct: 961 CHGNCVFTRWHYSEWSQCSRSC---------GGGERSRESYCMNNFGHRLADNECQELSR 1011
Query: 1392 ETRP-CTGGKCYHYTWKASLWNN---------NERTVWCQRSDGVNVTGGCSPQARPAAI 1441
TR C C +W AS W+ +R VWCQ + G C+ +P ++
Sbjct: 1012 VTRENCNEFSCP--SWAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESL 1069
Query: 1442 RQC-IPACRK----PFSYCTQGGVCG 1462
C + C P+ CT CG
Sbjct: 1070 SPCELHTCASWQVGPWGPCTT--TCG 1093
Score = 34.3 bits (77), Expect = 0.98
Identities = 26/99 (26%), Positives = 39/99 (39%), Gaps = 28/99 (28%)
Query: 916 HRGLRVQ----ADSKECGEGLRFRAVACSDKNG--RPVDPSFCSSSGYIQEKCVIPCPFD 969
H+G Q AD +CG G+ R C +K RPV+ +
Sbjct: 518 HKGCFTQHVPPADGTDCGPGMHCRHGLCVNKETETRPVNGEW------------------ 559
Query: 970 CKLSDWSSWGSCSSSCGIGVRIRSKWL-KEKPYNGGRPC 1007
W + SCS +CG G+ ++ + +P NGG C
Sbjct: 560 ---GPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYC 595
Score = 32.7 bits (73), Expect = 2.8
Identities = 19/55 (34%), Positives = 30/55 (54%), Gaps = 3/55 (5%)
Query: 156 PWSNCSKGCGKKLQHRTRAVIAP-PLFGGLQC-PNLTESRACDAPISCPLGEEEY 208
P+S+CS+ CG ++ TR P P GG C + R+C+ SCP G +++
Sbjct: 564 PYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTD-SCPKGTQDF 617
>gi|110347423 spondin 1, extracellular matrix protein [Homo sapiens]
Length = 807
Score = 144 bits (362), Expect = 9e-34
Identities = 127/434 (29%), Positives = 190/434 (43%), Gaps = 92/434 (21%)
Query: 959 QEKCVIPCPFDCKLSDWSSWGSCSSS-CGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQ 1017
+EK P C S+WS W +CSSS C G R+R + LK + + PCP
Sbjct: 432 EEKDEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQ-LDLSVPCP--------D 482
Query: 1018 VHEAVPCY---------SECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTAD 1068
+ PC S C W+ WS C I+ CG G +SR+ R V
Sbjct: 483 TQDFQPCMGPGCSDEDGSTCTMSEWIT--WSPCSIS-------CGMGMRSRE-RYVKQFP 532
Query: 1069 GEGGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEWGLWSKCPQSCDPHTMQRRTRHLLR 1128
E G+V + + E + CS P+ C+M+EWG W +C +C +R +
Sbjct: 533 -EDGSVCTLPTEETEKCTVNEECS---PSSCLMTEWGEWDECSATCGMGMKKRHRMIKMN 588
Query: 1129 PSLNSRTCAEDSQVQPCLLNENCFQFQYNL---TEWSTCQLSENAPCGQGVRT--RLLSC 1183
P+ S AE SQ + C++ E C L +EWS C ++ CG+G+RT R+L
Sbjct: 589 PADGSMCKAETSQAEKCMMPE-CHTIPCLLSPWSEWSDCSVT----CGKGMRTRQRMLKS 643
Query: 1184 VCSDGKPVSMDQCEQHNLEKPQRMSIPCLVECVVNCQLSGWTAWTECSQTCGHGGRMSRT 1243
+ G C + +LE+ ++ +P EC ++C+L+ W+ W+EC+++CG G + RT
Sbjct: 644 LAELG------DCNE-DLEQVEKCMLP---ECPIDCELTEWSQWSECNKSCGK-GHVIRT 692
Query: 1244 RFIIMPTQGEGRPCPTELTQEKTCPVTPCYSWVLGNWSACKLEGGDCGEGVQIRSLSCMV 1303
R I M Q G PCP E Q K C + C L N S KL + E
Sbjct: 693 RMIQMEPQFGGAPCP-ETVQRKKCRIRKC----LRNPSIQKLRWREARE----------- 736
Query: 1304 HSGSISHAAGRVEDALCGEMPFQDSILKQLCSVPCPGDCHLTEWSEWSTCELTCIDG--R 1361
S + ++++ GE PG C + W+ WS C C G
Sbjct: 737 -----SRRSEQLKEESEGEQ--------------FPG-CRMRPWTAWSECTKLCGGGIQE 776
Query: 1362 SFETVGRQSRSRTF 1375
+ TV ++ +S F
Sbjct: 777 RYMTVKKRFKSSQF 790
Score = 109 bits (272), Expect = 2e-23
Identities = 107/453 (23%), Positives = 177/453 (39%), Gaps = 105/453 (23%)
Query: 839 EDCTFTAWSKFTPCSTN-CEATKS-RRRQLTGKSRKKEKCQDS-DLYPLV-------ETE 888
E C ++ WS ++ CS++ C+ K R+R L + C D+ D P + +
Sbjct: 441 ETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGS 500
Query: 889 LCPCDEFISQPYGNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSDKNGRPVD 948
C E+I+ WS C S CG G+R R P D
Sbjct: 501 TCTMSEWIT-----WSPC------------------SISCGMGMRSRERYVKQF---PED 534
Query: 949 PSFCSSSGYIQEKCVIP---CPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKPYNGGR 1005
S C+ EKC + P C +++W W CS++CG+G++ R + +K P +G
Sbjct: 535 GSVCTLPTEETEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIKMNPADGSM 594
Query: 1006 PCPKLDLKNQAQVHEAVPCYS-ECNQYSWVVE---HWSSCKINNELRSLRCGGGTQSRKI 1061
C +A+ +A C EC+ ++ WS C S+ CG G ++R+
Sbjct: 595 -C-------KAETSQAEKCMMPECHTIPCLLSPWSEWSDC-------SVTCGKGMRTRQR 639
Query: 1062 RCVNTAD-GEGGAVDSNLCNQDEIPPETQSCSLM-CPNECVMSEWGLWSKCPQSCDPHTM 1119
+ A+ G+ CN+D + + C L CP +C ++EW WS+C +SC +
Sbjct: 640 MLKSLAELGD--------CNEDL--EQVEKCMLPECPIDCELTEWSQWSECNKSCGKGHV 689
Query: 1120 QRRTRHLLRPSLNSRTCAEDSQVQPCLLNENCFQFQYNLTEWSTCQLSENAPCGQGVRTR 1179
R + P C E Q + C + + C + P Q +R R
Sbjct: 690 IRTRMIQMEPQFGGAPCPETVQRKKCRIRK-CLR----------------NPSIQKLRWR 732
Query: 1180 LLSCVCSDGKPVSMDQCEQHNLEKPQRMSIPCLVECVVNCQLSGWTAWTECSQTCGHGGR 1239
E + +++ E C++ WTAW+EC++ CG GG
Sbjct: 733 -----------------EARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCG-GGI 774
Query: 1240 MSRTRFIIMPTQGEGRPCPTELTQEKTCPVTPC 1272
R + + + + + C V PC
Sbjct: 775 QERYMTVKKRFKSSQFTSCKDKKEIRACNVHPC 807
Score = 105 bits (263), Expect = 3e-22
Identities = 108/461 (23%), Positives = 175/461 (37%), Gaps = 123/461 (26%)
Query: 707 CIVTAFSEWTPCPRM-CQAGNATVKQSRYRIIIQEAANGGQECPDTLYEEREC------- 758
CI + +S W+ C C G K+ R R++ + + CPDT + + C
Sbjct: 443 CIYSNWSPWSACSSSTCDKG----KRMRQRML-KAQLDLSVPCPDT-QDFQPCMGPGCSD 496
Query: 759 EDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRA--VSCISDDNRSAEM 816
ED S C + W WSPC S +CG G+++R V +D
Sbjct: 497 EDGSTCTMSEWIT--WSPC--------------SISCGMGMRSRERYVKQFPEDGSV--- 537
Query: 817 MECLKQTNGMPLLVQECTV--PCR-EDCTFTAWSKFTPCSTNCEATKSRRRQL-----TG 868
C T ++CTV C C T W ++ CS C +R ++
Sbjct: 538 --CTLPTEE----TEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIKMNPAD 591
Query: 869 KSRKKEKCQDSDLYPLVETELCPCDEFISQPYGNWSDCILP--EGRREPHRGLRVQADSK 926
S K + ++ + E PC + P+ WSDC + +G R R L+ A+
Sbjct: 592 GSMCKAETSQAEKCMMPECHTIPC---LLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELG 648
Query: 927 ECGEGLRFRAVACSDKNGRPVDPSFCSSSGYIQEKCVIP-CPFDCKLSDWSSWGSCSSSC 985
+C E L EKC++P CP DC+L++WS W C+ SC
Sbjct: 649 DCNEDLEQ------------------------VEKCMLPECPIDCELTEWSQWSECNKSC 684
Query: 986 GIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHEAVPCYSECNQYSWVVEHWSSCKINN 1045
G G IR++ ++ +P GG PCP+ + + ++ + C N
Sbjct: 685 GKGHVIRTRMIQMEPQFGGAPCPETVQRKKCRIRK--------------------CLRNP 724
Query: 1046 ELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEWG 1105
++ LR +SR+ + + EG ++ P C M W
Sbjct: 725 SIQKLRWREARESRRSEQLK-EESEG----------EQFP------------GCRMRPWT 761
Query: 1106 LWSKCPQSCDPHTMQRRTRHLLR-PSLNSRTCAEDSQVQPC 1145
WS+C + C +R R S +C + +++ C
Sbjct: 762 AWSECTKLCGGGIQERYMTVKKRFKSSQFTSCKDKKEIRAC 802
Score = 102 bits (254), Expect = 3e-21
Identities = 88/324 (27%), Positives = 133/324 (41%), Gaps = 61/324 (18%)
Query: 1096 PNECVMSEWGLWSKCPQS-CDPHTMQRRTRHLLRPSLN-SRTCAEDSQVQPCLL------ 1147
P C+ S W WS C S CD +R + +L+ L+ S C + QPC+
Sbjct: 440 PETCIYSNWSPWSACSSSTCDKG--KRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDE 497
Query: 1148 -NENCFQFQYNLTEWSTCQLSENAPCGQGVRTR--LLSCVCSDGKPVSMDQCEQHNLEKP 1204
C ++ WS C +S CG G+R+R + DG ++ P
Sbjct: 498 DGSTCTMSEW--ITWSPCSIS----CGMGMRSRERYVKQFPEDGSVCTL----------P 541
Query: 1205 QRMSIPCLV--ECVVN-CQLSGWTAWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPTEL 1261
+ C V EC + C ++ W W ECS TCG G M + +I +G C E
Sbjct: 542 TEETEKCTVNEECSPSSCLMTEWGEWDECSATCGMG--MKKRHRMIKMNPADGSMCKAET 599
Query: 1262 TQEKTCPVTPCYS--WVLGNWSACKLEGGDCGEGVQIRS--LSCMVHSGSISHAAGRVED 1317
+Q + C + C++ +L WS CG+G++ R L + G + +VE
Sbjct: 600 SQAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEK 659
Query: 1318 ALCGEMPFQDSILKQLCSVPCPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFII 1377
+ E CP DC LTEWS+WS C +C G+ G R+R +
Sbjct: 660 CMLPE---------------CPIDCELTEWSQWSECNKSC--GK-----GHVIRTRMIQM 697
Query: 1378 QSFENQDSCPQQVLETRPCTGGKC 1401
+ CP+ V + + C KC
Sbjct: 698 EPQFGGAPCPETV-QRKKCRIRKC 720
Score = 102 bits (254), Expect = 3e-21
Identities = 109/419 (26%), Positives = 166/419 (39%), Gaps = 89/419 (21%)
Query: 454 CIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVESVPCEDPMCY- 512
CI S+WS W C C KG R RQR +L + CP + PC P C
Sbjct: 443 CIYSNWSPWSACSSSTCD-----KGKRMRQR-MLKAQLDLSVPCPDTQDFQPCMGPGCSD 496
Query: 513 ----RWLASEGICF-PDHGKCGLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSCEI-- 565
SE I + P CG+G R + + + GS+C +P E + C +
Sbjct: 497 EDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPED---GSVCTLPTE-ETEKCTVNE 552
Query: 566 PCR-MDCVLSEWTEWSSCSQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHRL- 623
C C+++EW EW CS +C G + R R I +G C + E +
Sbjct: 553 ECSPSSCLMTEWGEWDECSATCGM----GMKKRHRMIKMNPADGSM-CKAETSQAEKCMM 607
Query: 624 --CNDHSCMQLHWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTR-RVFCVKSHVG 680
C+ C+ W S W CS TCG G++TR R+ + +G
Sbjct: 608 PECHTIPCLLSPW--SEWSDCS-----------------VTCGKGMRTRQRMLKSLAELG 648
Query: 681 QVMTKRCPDSTRPETVRPCFLP-CKKDCIVTAFSEWTPCPRMCQAGNATVKQSRYRIIIQ 739
C + E V C LP C DC +T +S+W+ C + C G+ R R+I
Sbjct: 649 D-----CNEDL--EQVEKCMLPECPIDCELTEWSQWSECNKSCGKGHVI----RTRMIQM 697
Query: 740 EAANGGQECPDTLYEE----RECEDVSLCPVYRWKP----------------QKWSPCIL 779
E GG CP+T+ + R+C RW+ +++ C +
Sbjct: 698 EPQFGGAPCPETVQRKKCRIRKCLRNPSIQKLRWREARESRRSEQLKEESEGEQFPGCRM 757
Query: 780 VPESVWQGITGSSEACGKGLQTRAVSCISDDNRSAEMMECLKQTNGMPLLVQECTV-PC 837
P + W T + CG G+Q R ++ + +S++ C + ++ C V PC
Sbjct: 758 RPWTAWSECT---KLCGGGIQERYMT-VKKRFKSSQFTSCKDKKE-----IRACNVHPC 807
Score = 86.7 bits (213), Expect = 2e-16
Identities = 109/429 (25%), Positives = 162/429 (37%), Gaps = 93/429 (21%)
Query: 303 PKDCETSQWSSWSPCSK-TCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEG 361
P+ C S WS WS CS TC G R R R +K + CP+ + + C+ G
Sbjct: 440 PETCIYSNWSPWSACSSSTCDKGK-----RMRQRMLKAQ-LDLSVPCPDTQDFQPCMGPG 493
Query: 362 ---ELLQQCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAA 418
E C W T W C +S CG G+++RE Y Q
Sbjct: 494 CSDEDGSTCTMSEWIT--WSPCSIS----------------CGMGMRSRERYVKQF---- 531
Query: 419 AALRAKEVSRPVEKALCVGPAPLPSQLCNI--PCS-TDCIVSSWSAWGLCIHENCHDPQG 475
P + ++C P ++ C + CS + C+++ W W C C
Sbjct: 532 ----------PEDGSVCTLPTE-ETEKCTVNEECSPSSCLMTEWGEWDEC-SATCG---- 575
Query: 476 KKGFRTRQRHVLMESTGPAGHCPHLVESVPCEDPMCYR--WLASEGICFPDHG-KCGLG- 531
G + R R + M + ++ C P C+ L S + D CG G
Sbjct: 576 -MGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGM 634
Query: 532 ---HRILKAVCQ-NDRGEDVSGSLCPVPPPPERKSCEIP-CRMDCVLSEWTEWSSCSQSC 586
R+LK++ + D ED+ + + C +P C +DC L+EW++WS C++SC
Sbjct: 635 RTRQRMLKSLAELGDCNEDLE----------QVEKCMLPECPIDCELTEWSQWSECNKSC 684
Query: 587 SNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHRL---CNDHSCMQLHWETSPWGPCS 643
G R+R I GG PCP + ++ R+ + S +L W + S
Sbjct: 685 GK----GHVIRTRMIQMEPQFGGAPCPETVQRKKCRIRKCLRNPSIQKLRWREARESRRS 740
Query: 644 EDTLVTA---------LNATIGWNGEAT--CGVGIQTRRVFCVKSHVGQVMTKRCPD--S 690
E + + W+ E T CG GIQ R VK C D
Sbjct: 741 EQLKEESEGEQFPGCRMRPWTAWS-ECTKLCGGGIQ-ERYMTVKKRFKSSQFTSCKDKKE 798
Query: 691 TRPETVRPC 699
R V PC
Sbjct: 799 IRACNVHPC 807
Score = 81.6 bits (200), Expect = 5e-15
Identities = 102/487 (20%), Positives = 163/487 (33%), Gaps = 122/487 (25%)
Query: 146 PRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPNLTESRACDAPISCPLGE 205
P C+ S + PWS CS K + + ++ L + CP+ + + C P
Sbjct: 440 PETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDG 499
Query: 206 EEYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDSNERVTFKHQSYKAHHHSKSWAIE 265
T S + WS C + +
Sbjct: 500 STCTMSEWI-TWSPCSI----------------------------------------SCG 518
Query: 266 IGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCETSQWSSWSPCSKTCRSGS 325
+G ++R+ + ++ +L +++ TV P C ++W W CS TC
Sbjct: 519 MGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCLMTEWGEWDECSATCGM-- 576
Query: 326 LLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEGELLQQCPRYSWRTSEWKECQVSLL 385
G + R R +K G E + E C++ C W SEW +C V+
Sbjct: 577 ---GMKKRHRMIKMNPADGSMCKAETSQAEKCMMPECHTIPCLLSPW--SEWSDCSVT-- 629
Query: 386 LEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAAL-RAKEVSRPVEKALCVGPAPLPSQ 444
CG G++TR+ + + + A L E VEK
Sbjct: 630 --------------CGKGMRTRQ----RMLKSLAELGDCNEDLEQVEK------------ 659
Query: 445 LCNIP-CSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVES 503
C +P C DC ++ WS W C +++C KG R R + ME CP V+
Sbjct: 660 -CMLPECPIDCELTEWSQWSEC-NKSC-----GKGHVIRTRMIQMEPQFGGAPCPETVQR 712
Query: 504 VPCEDPMCYRWLASEGICFPDHGKCGLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSC 563
C C R + + + + + + R + + + GE G
Sbjct: 713 KKCRIRKCLRNPSIQKLRWREARE----SRRSEQLKEESEGEQFPG-------------- 754
Query: 564 EIPCRMDCVLSEWTEWSSCSQSCSNKNSDGKQTRSRTI-LALAGEGGKPCPPSQALQEHR 622
C + WT WS C++ C G Q R T+ C +E R
Sbjct: 755 -------CRMRPWTAWSECTKLCGG----GIQERYMTVKKRFKSSQFTSCKDK---KEIR 800
Query: 623 LCNDHSC 629
CN H C
Sbjct: 801 ACNVHPC 807
Score = 75.1 bits (183), Expect = 5e-13
Identities = 81/315 (25%), Positives = 128/315 (40%), Gaps = 70/315 (22%)
Query: 139 QACLIPCPRD-----CVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPNLTESR 193
Q C+ P D C +SE++ WS CS CG ++ R R V P G + E+
Sbjct: 487 QPCMGPGCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETE 546
Query: 194 ACD-----APISCPLGEEEYTFSLKVGPWSKC---------RLPHLKEINPSGRTVLDFN 239
C +P SC + E G W +C + + ++NP+ ++
Sbjct: 547 KCTVNEECSPSSCLMTE--------WGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAE 598
Query: 240 SDSNERVTFKH-------QSYKAHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDS 292
+ E+ S + S G +TRQ R A L C +D
Sbjct: 599 TSQAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQ----RMLKSLAELGDCNEDL 654
Query: 293 FPLTVQSCIMPK---DCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECP 349
V+ C++P+ DCE ++WS WS C+K+C G ++ R+R ++ GG CP
Sbjct: 655 --EQVEKCMLPECPIDCELTEWSQWSECNKSCGKGHVI-----RTRMIQMEPQFGGAPCP 707
Query: 350 ELLEKEACIVEGELLQQCPRY-SWRTSEWKECQVSLLLEQ--------QDP--------H 392
E ++++ C +++C R S + W+E + S EQ Q P
Sbjct: 708 ETVQRKKC-----RIRKCLRNPSIQKLRWREARESRRSEQLKEESEGEQFPGCRMRPWTA 762
Query: 393 WHVTGPVCGGGIQTR 407
W +CGGGIQ R
Sbjct: 763 WSECTKLCGGGIQER 777
Score = 60.1 bits (144), Expect = 2e-08
Identities = 51/183 (27%), Positives = 72/183 (39%), Gaps = 35/183 (19%)
Query: 16 GPWGRCTGDCGPG-GVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFRVCDWHSDLFQ 74
G W C+ CG G + R + DG S C ++ E+ C L
Sbjct: 565 GEWDECSATCGMGMKKRHRMIKMNPADG-----SMC-KAETSQAEKCMMPECHTIPCLLS 618
Query: 75 -WEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHFAL 133
W S+W C VT G++ R R ++ L NE E
Sbjct: 619 PW--SEWSDC----------------SVTCGKGMRTRQ-RMLKSLAELGDCNEDLEQV-- 657
Query: 134 QPPTEQACLIP-CPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPNLTES 192
+ C++P CP DC ++E+ WS C+K CGK RTR + P FGG CP +
Sbjct: 658 -----EKCMLPECPIDCELTEWSQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQR 712
Query: 193 RAC 195
+ C
Sbjct: 713 KKC 715
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 143 bits (361), Expect = 1e-33
Identities = 334/1462 (22%), Positives = 470/1462 (32%), Gaps = 387/1462 (26%)
Query: 78 SDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVAN--EICEHFALQP 135
S+W C + + R C T QHG C + + E C +A
Sbjct: 3415 SEWTMCSQPCRGQTRSRSRACACPTPQHG----GAPCTGEAGEAGAQHQREACPSYAT-- 3468
Query: 136 PTEQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPL-FGGLQCP-NLTESR 193
CP D + PWS C G+ HR+RA PP GG CP N T+SR
Sbjct: 3469 ---------CPVDGAWGPWGPWSPCDMCLGQ--SHRSRACSRPPTPEGGRPCPGNHTQSR 3517
Query: 194 AC-DAPISC----------PLGEEEYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDS 242
C + C P G+ + P S C+ P P+ L S
Sbjct: 3518 PCQENSTQCTDCGGGQSLHPCGQPCPRSCQDLSPGSVCQ-PGSVGCQPTCGCPLGQLSQD 3576
Query: 243 NERVTFKH---------------QSYKAHHHSKSW-AIEIGYQTRQVSCTRSDGQNAMLS 286
V H QS A SW ++E G +
Sbjct: 3577 GLCVPPAHCRCQYQPGAMGIPENQSRSAGSRFSSWESLEPG--------------EVVTG 3622
Query: 287 LCLQDSFPLTVQSCIMPKDC-ETSQWSSWSP---CSKTCRSGSLLPGFRSRSRNVKHMAI 342
C + + C DC + WSSW P CS +C G L RSR
Sbjct: 3623 PCDNCTCVAGILQCQEVPDCPDPGVWSSWGPWEDCSVSCGGGEQL-----RSRRCARPPC 3677
Query: 343 GG----GKECPELLEKEACIVEGELLQQ------CPRYSWRTSEWKECQVSLLLEQQDPH 392
G + C + +EA G L ++ CP ++ QV E +
Sbjct: 3678 PGPARQSRTCSTQVCREAGCPAGRLYRECQPGEGCPFSCAHVTQ----QVGCFSEGCEEG 3733
Query: 393 WHVTGPVCGGGIQTREVYCAQSVPAA-AALRAKEVSRPV-EKALCVGPA-------PLPS 443
H C G + C Q P A +E+ + + +GP L +
Sbjct: 3734 CH-----CPEGTFQHRLACVQECPCVLTAWLLQELGATIGDPGQPLGPGDELDSGQTLRT 3788
Query: 444 QLCNIPCS--------TDCIVSS-----WSAWGLCIHENCHDPQGKKGFRTRQRHVLMES 490
N C+ DC + WS WG C +C G G RTR R ++
Sbjct: 3789 SCGNCSCAHGKLSCSLDDCFEADGGFGPWSPWGPC-SRSC----GGLGTRTRSRQCVLTM 3843
Query: 491 TGPAGH-CPHLVESVPCEDPMC---------------------YRWLASEGICFPDHGKC 528
+G C + + C P C W C D +
Sbjct: 3844 PTLSGQGCRGPRQDLECPSPDCPGAEGSTVEPVTGLPGGWGPWSSWSPCSRSC-TDPARP 3902
Query: 529 GLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSCEIP-CRM-DCVLSEWTEWSSCSQSC 586
R + G+ + C +P E C P C +C + W W CS+SC
Sbjct: 3903 AWRSRTRLCLANCTMGDPLQERPCNLPSCTELPVCPGPGCGAGNCSWTSWAPWEPCSRSC 3962
Query: 587 SNKNSDGKQTRSRTILALAGEGGKPCPP-SQALQEHRLCNDHSC-MQLHWET-SPWGPCS 643
G+Q R R G GG CP A QE R CN +C + W SPW C
Sbjct: 3963 ----GVGQQRRLRAYRP-PGPGGHWCPNILTAYQERRFCNLRACPVPGGWSRWSPWSWC- 4016
Query: 644 EDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPETVRPCF-LP 702
+ +CG G R C P + R C +P
Sbjct: 4017 ----------------DRSCGGGQSLRSRSCSSP---PSKNGGAPCAGERHQARLCNPMP 4057
Query: 703 CKKDC-----IVTAFSEWTPCPRMCQAGNATVKQSRYRIIIQ--EAANGGQECP-DTLYE 754
C+ C +VT + CPR C + I+ Q + G CP +L +
Sbjct: 4058 CEAGCPAGMEVVTCANR---CPRRC-------SDLQEGIVCQDDQVCQKGCRCPKGSLEQ 4107
Query: 755 ERECEDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCISDDNRSA 814
+ C + C + W+P + +AC
Sbjct: 4108 DGGCVPIGHCDCTDAQGHSWAPG-----------SQHQDACN------------------ 4138
Query: 815 EMMECLKQTNGMPLLVQECTVPCREDCTFTAWSKFTPCSTNC--EATKSRRRQLTGKSRK 872
C Q + Q C P C ++ WS ++PCS +C +SR R T S
Sbjct: 4139 ---NCSCQAGQLSCTAQPCPPPTH--CAWSHWSAWSPCSHSCGPRGQQSRFRSSTSGSWA 4193
Query: 873 KEKCQDSDLYPLVETELCPCDEFISQPYGNWSDCILPEGRREPHRGLRVQADSKECGEGL 932
E C++ +++ PC + P C+ +G R R DS GE
Sbjct: 4194 PE-CREE------QSQSQPCPQPSCPPL-----CL--QGTRS-----RTLGDSWLQGECQ 4234
Query: 933 RFRAVACSDKNGRPVDPSFCSSSGYIQE--KCVIPCPFDCKLSDWSSWGSCSSSCGIGVR 990
R CS C+ G I E +C +P + WSSW C SCG G +
Sbjct: 4235 R-----CS-----------CTPEGVICEDTECAVPEAWTL----WSSWSDCPVSCGGGNQ 4274
Query: 991 IRSKWLK-EKPYNGGRPCPKLDLKNQAQVHEAVPCYSECNQYSWVVEHWSSCKINNELRS 1049
+R++ + P++ PC D + + Q PC SW W C S
Sbjct: 4275 VRTRACRAAAPHHRSPPCLGPDTQTRQQ-----PCPGLLEACSW--GPWGPC-------S 4320
Query: 1050 LRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQSC-SLMCPNECVMSEWGLWS 1108
CG G SR C A CN + +TQ C S CP ECV S W W+
Sbjct: 4321 RSCGPGLASRSGSCPCLM-----AKADPTCNSTFLHLDTQGCYSGPCPEECVWSSWSSWT 4375
Query: 1109 KCPQSCDPHTMQRRTRHLLRPSLNSRTCAE----DSQVQPCLLNENCFQFQYNLT-EWST 1163
+C SC +Q+R RH S +R A D +PCL++ NC + E+
Sbjct: 4376 RC--SCRV-LVQQRYRHQGPASRGARAGAPCTRLDGHFRPCLIS-NCSEDSCTPPFEFHA 4431
Query: 1164 CQLSENAPCGQGVRTRLLSCVCSDGKP------------------VSMDQCE-------- 1197
C +PC T L +C D P + ++C
Sbjct: 4432 C----GSPCAGLCATHLSHQLCQDLPPCQPGCYCPKGLLEQAGGCIPPEECNCWHTSAAG 4487
Query: 1198 -QHNLEKPQRMSIPCL-VEC--------VVNCQ----LSGWTAWTEC------------S 1231
L R+ + C EC CQ LS W+ W+ C S
Sbjct: 4488 AGMTLAPGDRLQLGCKECECRRGELHCTSQGCQGLLPLSEWSEWSPCGPCLPPSALAPAS 4547
Query: 1232 QTCGH------------------GGRMSRTRFIIMPTQGE---GRP--CPTELTQEKTCP 1268
+T R R + P G G P C L+Q++ CP
Sbjct: 4548 RTALEEHWLRDPTGLSPTLAPLLASEQHRHRLCLDPATGRPWTGAPHLCTAPLSQQRLCP 4607
Query: 1269 -----VTPCYSWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISH---AAGRVEDALC 1320
C + G WS C++ C G ++R G A C
Sbjct: 4608 DPGACPDSCQWSLWGPWSPCQV---PCSGGFRLRWREAEALCGGGCREPWAQESCNGGPC 4664
Query: 1321 GEMPFQDSILKQLCSVPCPGDC 1342
E QD++ C+ CP C
Sbjct: 4665 PECEAQDTVFTLDCANQCPHSC 4686
Score = 138 bits (347), Expect = 5e-32
Identities = 317/1360 (23%), Positives = 453/1360 (33%), Gaps = 331/1360 (24%)
Query: 138 EQACLIP-CPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFG-GLQCPN-LTESRA 194
E+ CL+ C R + PWS+CS+ CG L+ RTRA PP G G C +
Sbjct: 3241 EEPCLLQGCDRAGGWGPWGPWSHCSRSCGGGLRSRTRACDQPPPQGLGDYCEGPRAQGEV 3300
Query: 195 CDAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEIN---------------PSGRTVLDFN 239
C A + CP+ +++ +S C P + + P G+ +
Sbjct: 3301 CQA-LPCPVTN---CTAIEGAEYSPCGPPCPRSCDDLVHCVWRCQPGCYCPPGQVL---- 3352
Query: 240 SDSNERVTFKHQSYKAHHHSKSWAIEIGYQTRQ-VSCTRSDGQNAMLSLCLQDSFPLTVQ 298
SN + + H + G + R DG N CL+ T
Sbjct: 3353 -SSNGAICVQPG------HCSCLDLLTGQRHHPGARLARPDGCNHCT--CLEGRLNCTDL 3403
Query: 299 SCIMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSR-----NVKHMAIGGGKECPELLE 353
C +P WS W+ CS+ CR + RSRSR +H GG C
Sbjct: 3404 PCPVPGGW--CPWSEWTMCSQPCRGQT-----RSRSRACACPTPQH----GGAPCTGEAG 3452
Query: 354 KEACIVEGELLQQCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQ 413
+ + E CP Y+ C V D W GP +
Sbjct: 3453 EAGAQHQREA---CPSYA-------TCPV-------DGAWGPWGP-----------WSPC 3484
Query: 414 SVPAAAALRAKEVSRPVEKALCVGPAPLP-SQLCNIPCSTDCIVSSWSAWGLCIHENCHD 472
+ + R++ SRP G P P + + PC + + G +H C
Sbjct: 3485 DMCLGQSHRSRACSRPPTPE---GGRPCPGNHTQSRPCQENSTQCTDCGGGQSLHP-CGQ 3540
Query: 473 PQGKKGFRTRQRHVLMESTGPAGHCPHLVESVPCEDPMC---YRWLASEGICFPD-HGKC 528
P + + P C SV C+ P C L+ +G+C P H +C
Sbjct: 3541 PCPRS----------CQDLSPGSVCQP--GSVGCQ-PTCGCPLGQLSQDGLCVPPAHCRC 3587
Query: 529 GL--GHRILKAVCQNDRGEDVSG--SLCP---VPPPPERKSC--------EIP-CRMDCV 572
G + G S SL P V P + +C E+P C V
Sbjct: 3588 QYQPGAMGIPENQSRSAGSRFSSWESLEPGEVVTGPCDNCTCVAGILQCQEVPDCPDPGV 3647
Query: 573 LSEWTEWSSCSQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHRLCNDHSCMQL 632
S W W CS SC G+Q RSR PCP ++ R C+ C +
Sbjct: 3648 WSSWGPWEDCSVSCGG----GEQLRSRRCAR------PPCPGPA--RQSRTCSTQVCRE- 3694
Query: 633 HWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTR 692
C L G T++V C G CP+ T
Sbjct: 3695 -------AGCPAGRLYRECQPGEG----CPFSCAHVTQQVGCFSE--GCEEGCHCPEGTF 3741
Query: 693 PETVRPCFLPCKKDCIVTAFSEWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQECPDTL 752
+ C C C++TA+ + Q AT+ + + + GQ +
Sbjct: 3742 QHRLA-CVQECP--CVLTAW--------LLQELGATIGDPGQPLGPGDELDSGQTLRTSC 3790
Query: 753 ------YEERECE-------DVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACGK-G 798
+ + C D P W P W PC S +CG G
Sbjct: 3791 GNCSCAHGKLSCSLDDCFEADGGFGP---WSP--WGPC--------------SRSCGGLG 3831
Query: 799 LQTRAVSCISDDNRSAEMMECLKQTNGMPLLVQECTVPCREDCT---------------- 842
+TR+ C+ M Q P EC P DC
Sbjct: 3832 TRTRSRQCV------LTMPTLSGQGCRGPRQDLECPSP---DCPGAEGSTVEPVTGLPGG 3882
Query: 843 FTAWSKFTPCSTNCE-----ATKSRRRQLTGKSRKKEKCQDS--DLYPLVETELCP---- 891
+ WS ++PCS +C A +SR R + Q+ +L E +CP
Sbjct: 3883 WGPWSSWSPCSRSCTDPARPAWRSRTRLCLANCTMGDPLQERPCNLPSCTELPVCPGPGC 3942
Query: 892 -CDEFISQPYGNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSDKNGRPVDPS 950
+ W C S+ CG G + R A RP P
Sbjct: 3943 GAGNCSWTSWAPWEPC------------------SRSCGVGQQRRLRAY-----RPPGPG 3979
Query: 951 --FCSS--SGYIQEK-CVI-PCPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKPY-NG 1003
+C + + Y + + C + CP S WS W C SCG G +RS+ P NG
Sbjct: 3980 GHWCPNILTAYQERRFCNLRACPVPGGWSRWSPWSWCDRSCGGGQSLRSRSCSSPPSKNG 4039
Query: 1004 GRPCPKLDLKNQAQVHEAVPCYSECNQYSWVVEHWSSCKIN-NEL-------------RS 1049
G PC ++QA++ +PC + C VV + C ++L +
Sbjct: 4040 GAPCA--GERHQARLCNPMPCEAGCPAGMEVVTCANRCPRRCSDLQEGIVCQDDQVCQKG 4097
Query: 1050 LRCGGGTQSRKIRCV-----NTADGEG-----GAVDSNLCNQDEIPPETQSCSLM-CP-- 1096
RC G+ + CV + D +G G+ + CN SC+ CP
Sbjct: 4098 CRCPKGSLEQDGGCVPIGHCDCTDAQGHSWAPGSQHQDACNNCSCQAGQLSCTAQPCPPP 4157
Query: 1097 NECVMSEWGLWSKCPQSCDPHTMQRRTRHLLRPSLNSRTCAEDSQVQPCLLNENCFQFQY 1156
C S W WS C SC P Q R R S E SQ QPC
Sbjct: 4158 THCAWSHWSAWSPCSHSCGPRGQQSRFRSSTSGSWAPECREEQSQSQPC----------- 4206
Query: 1157 NLTEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHNLEKPQRMSIPCL-VEC 1215
Q S C QG R+R L G +C++ + + C EC
Sbjct: 4207 -------PQPSCPPLCLQGTRSRTL------GDSWLQGECQRCSCTPE---GVICEDTEC 4250
Query: 1216 VVNCQLSGWTAWTECSQTCGHGGRMSRTRFI-IMPTQGEGRPC--PTELTQEKTCP-VTP 1271
V + W++W++C +CG GG RTR PC P T+++ CP +
Sbjct: 4251 AVPEAWTLWSSWSDCPVSCG-GGNQVRTRACRAAAPHHRSPPCLGPDTQTRQQPCPGLLE 4309
Query: 1272 CYSWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSILK 1331
SW G W C CG G+ RS SC D C F +
Sbjct: 4310 ACSW--GPWGPC---SRSCGPGLASRSGSCPCLMAK--------ADPTCNS-TFLHLDTQ 4355
Query: 1332 QLCSVPCPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSR 1371
S PCP +C + WS W+ C + + + G SR
Sbjct: 4356 GCYSGPCPEECVWSSWSSWTRCSCRVLVQQRYRHQGPASR 4395
Score = 125 bits (315), Expect = 2e-28
Identities = 302/1340 (22%), Positives = 417/1340 (31%), Gaps = 373/1340 (27%)
Query: 305 DCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECP-ELLEKEACIVEGEL 363
DC + WS WS CS++C G R ++ GG CP + ++C V
Sbjct: 2500 DCVLAPWSVWSSCSRSCGLGLTF----QRQELLRPPLPGG--SCPRDRFRSQSCFV---- 2549
Query: 364 LQQCP-RYSWRTSE-WKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAAL 421
Q CP +W E W C VS CGGG Q+R+ C P
Sbjct: 2550 -QACPVAGAWAMWEAWGPCSVS----------------CGGGHQSRQRSCVDPPPKNGGA 2592
Query: 422 RAKEVSRPVEKALC------------VGPAPLPSQLCN----IPCSTDCI--VSSWSAWG 463
S+ E+A C +G + + LC PC C+ ++ S G
Sbjct: 2593 PCPGASQ--ERAPCGLQPCSGGTDCELGRVYVSADLCQKGLVPPCPPSCLDPKANRSCSG 2650
Query: 464 LCIHENCHDPQGKKGFRTRQRHVLMESTG--PAGHCPHLVESV-----------PCEDPM 510
C+ E C P G +L+ T P CP LV C +
Sbjct: 2651 HCV-EGCRCPPG----------LLLHDTRCLPLSECPCLVGEELKWPGVSFLLGNCSQCV 2699
Query: 511 CYRWLASEGICFPDHG--KCGLGHRILKAVCQNDRGEDVSGSLCPVPPPP---------- 558
C + E +C P CG A C G V PP
Sbjct: 2700 CEK---GELLCQPGGCPLPCGWSAWSSWAPCDRSCGSGVRARFRSPSNPPAAWGGAPCEG 2756
Query: 559 ---ERKSCEIPCRMDCV-LSEWTEWSSCSQSC-SNKNSDGKQTRSRTILALAGEGGKPCP 613
E + C C + + WT WSSCSQSC + G ++RSR L G
Sbjct: 2757 DRQELQGCHTVCGTEVFGWTPWTSWSSCSQSCLAPGGGPGWRSRSR----LCPSPGDSSC 2812
Query: 614 PSQALQEHRLCNDHSC-MQLHWET-SPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRR 671
P A QE C+ C + W +PW CS A C GIQTR
Sbjct: 2813 PGDATQEEP-CSPPVCPVPSIWGLWAPWSTCS-----------------APCDGGIQTRG 2854
Query: 672 VFCVKSHVGQVMTKRCPDSTRPETVRPCFLPCKKDCIVTA----FSEWTPCPRMCQAGNA 727
C G TR +PC C ++ + + E PCPR+C
Sbjct: 2855 RSCSSLAPGDTTCPGPHSQTRDCNTQPCTAQCPENMLFRSAEQCHQEGGPCPRLCLTQGP 2914
Query: 728 TVKQSRYRIIIQEAANGGQECPDTLY-EERECEDVSLCPVYRWKPQKWSPCILVPESVWQ 786
++ + + G CP L+ C S C PC L +
Sbjct: 2915 GIECTGF-------CAPGCTCPPGLFLHNASCLPRSQC-----------PCQLHGQLYAS 2956
Query: 787 GITGSSEACGKGLQTRAVSCISDDNRSAEMMECLKQTNGMPLLVQECTVPCREDCTFTAW 846
G ++C +C+S M C + C C ++ W
Sbjct: 2957 GAMARLDSCNN------CTCVSG------KMACTSER-------------CPVACGWSPW 2991
Query: 847 SKFTPCSTNCEATKSRRRQLTGKSRKK----EKCQDSDLYPLVETELC---PCDEFISQP 899
+ ++ CS +C RRR G + +CQ P +E E C PC
Sbjct: 2992 TLWSLCSCSCN-VGIRRRFRAGTAPPAAFGGAECQG----PTMEAEFCSLRPCPG-PGGE 3045
Query: 900 YGNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSDKNGRPVDPSFCSSSGYIQ 959
+G WS C +P CG G R R R S S
Sbjct: 3046 WGPWSPCSVP------------------CGGGYRNRT--------RGSSRSLMEFSTCGL 3079
Query: 960 EKCVIPCPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPK--LDLKNQAQ 1017
+ C P P C W C+ + + + + G CP L L N
Sbjct: 3080 QPCAGPVPGMCPRD--KQWLDCAQGPASCAELSAPRGTNQTCHPGCHCPSGMLLLNNVCV 3137
Query: 1018 VHEAVPCYSECNQY---SWVVEHWSSCKINNEL------------------------RSL 1050
+ PC E + Y S VV +C + L S
Sbjct: 3138 PTQDCPCAHEGHLYPPGSTVVRPCENCSCVSGLIANCSSWPCAEGEPTWSPWTPWSQCSA 3197
Query: 1051 RCGGGTQSRKIRCVNTADGEGG--------AVDSNLCNQDEIPPETQSCSLM-CPNECVM 1101
CG R C + A + LC+ E E + C L C
Sbjct: 3198 SCGPARCHRHRFCARSPSAVPSTVAPLPLPATPTPLCSGPE--AEEEPCLLQGCDRAGGW 3255
Query: 1102 SEWGLWSKCPQSCDPHTMQRRTRHLLRPSLNSRTCAEDSQVQPCLLNENCFQFQYNLTEW 1161
WG WS C +SC ++ RTR +P D P E C +T
Sbjct: 3256 GPWGPWSHCSRSCG-GGLRSRTRACDQPPPQG---LGDYCEGPRAQGEVCQALPCPVTNC 3311
Query: 1162 STCQLSENAPCGQGVRTR---LLSCV--------CSDGKPVSMDQC-------------- 1196
+ + +E +PCG L+ CV C G+ +S +
Sbjct: 3312 TAIEGAEYSPCGPPCPRSCDDLVHCVWRCQPGCYCPPGQVLSSNGAICVQPGHCSCLDLL 3371
Query: 1197 --EQHN----LEKPQRMSIPCLVECVVNCQ---------LSGWTAWTECSQTCGHGGRMS 1241
++H+ L +P + +E +NC W+ WT CSQ C G S
Sbjct: 3372 TGQRHHPGARLARPDGCNHCTCLEGRLNCTDLPCPVPGGWCPWSEWTMCSQPC-RGQTRS 3430
Query: 1242 RTRFIIMPT-QGEGRPCPTELTQE------------KTCPVTPCYS-WVLGNWSACKL-- 1285
R+R PT Q G PC E + TCPV + W G WS C +
Sbjct: 3431 RSRACACPTPQHGGAPCTGEAGEAGAQHQREACPSYATCPVDGAWGPW--GPWSPCDMCL 3488
Query: 1286 ---------------EGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSIL 1330
EGG G +S C +S + G CG+
Sbjct: 3489 GQSHRSRACSRPPTPEGGRPCPGNHTQSRPCQENSTQCTDCGGGQSLHPCGQ-------- 3540
Query: 1331 KQLCSVPCPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQSFENQDSCPQQV 1390
PCP C + S S C+ +VG Q CP
Sbjct: 3541 ------PCPRSCQ--DLSPGSVCQP--------GSVGCQPTC------------GCPLGQ 3572
Query: 1391 LETR----PCTGGKCYHYTWKASLWNNNERTV------WCQRSDGVNVTGGCSPQARPAA 1440
L P +C + + N R+ W G VTG C A
Sbjct: 3573 LSQDGLCVPPAHCRCQYQPGAMGIPENQSRSAGSRFSSWESLEPGEVVTGPCDNCTCVAG 3632
Query: 1441 IRQC--IPACRKPFSYCTQG 1458
I QC +P C P + + G
Sbjct: 3633 ILQCQEVPDCPDPGVWSSWG 3652
Score = 125 bits (315), Expect = 2e-28
Identities = 308/1384 (22%), Positives = 433/1384 (31%), Gaps = 408/1384 (29%)
Query: 156 PWSNCSKGCGKKLQHRTRA---VIAPPLFGGLQCPNLTESRACDAPISCPLGEEEYTFSL 212
PW CS+ CG L RTR+ V+ P G C + C +P CP G E T
Sbjct: 3819 PWGPCSRSCGG-LGTRTRSRQCVLTMPTLSGQGCRGPRQDLECPSP-DCP-GAEGSTVEP 3875
Query: 213 KVG------PWSKCRLPHLKEINPSGRTVLDFNSDSNERVTFKHQSYKAHHHSKSWAIEI 266
G PWS +P R+ D R ++ ++
Sbjct: 3876 VTGLPGGWGPWSSW--------SPCSRSCTD-----PARPAWRSRT-------------- 3908
Query: 267 GYQTRQVSCTRSDG-QNAMLSLCLQDSFPLTVQSCIMPKDCETSQWSSWSPCSKTCRSGS 325
+ +CT D Q +L P+ +C + W+ W PCS++C G
Sbjct: 3909 --RLCLANCTMGDPLQERPCNLPSCTELPVCPGPGCGAGNCSWTSWAPWEPCSRSCGVG- 3965
Query: 326 LLPGFRSRSRNVKHMAIGGGKECPELL----EKEACIVEGELLQQCP-RYSW-RTSEWKE 379
+ R GG CP +L E+ C L+ CP W R S W
Sbjct: 3966 -----QQRRLRAYRPPGPGGHWCPNILTAYQERRFCN-----LRACPVPGGWSRWSPWSW 4015
Query: 380 CQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEK---ALCV 436
C S CGGG +LR++ S P K A C
Sbjct: 4016 CDRS----------------CGGG---------------QSLRSRSCSSPPSKNGGAPCA 4044
Query: 437 GPAPLPSQLCN-IPCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAG 495
G ++LCN +PC C P G ME A
Sbjct: 4045 GERH-QARLCNPMPCEAGC------------------PAG------------MEVVTCAN 4073
Query: 496 HCPH----LVESVPCEDP-MCYRW-------LASEGICFP-DHGKC----------GLGH 532
CP L E + C+D +C + L +G C P H C G H
Sbjct: 4074 RCPRRCSDLQEGIVCQDDQVCQKGCRCPKGSLEQDGGCVPIGHCDCTDAQGHSWAPGSQH 4133
Query: 533 RILKAVCQNDRGEDVSGSLCPVPPPPERKSCEIPCRMDCVLSEWTEWSSCSQSCSNKNSD 592
+ C G+ +S + P PPP C S W+ WS CS SC +
Sbjct: 4134 QDACNNCSCQAGQ-LSCTAQPCPPPTH-----------CAWSHWSAWSPCSHSCGPR--- 4178
Query: 593 GKQTRSRTILALAGEGGKPCPPSQALQEHRLCNDHSCMQLHWETSPWGPCSEDTLVTALN 652
G+Q+R R+ + +G C Q+ + + C SC L C + T L
Sbjct: 4179 GQQSRFRS--STSGSWAPECREEQS--QSQPCPQPSCPPL---------CLQGTRSRTLG 4225
Query: 653 ATIGW-NGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPETVRPCFLPCKKDCIVTA 711
+ W GE +RC S PE V C T
Sbjct: 4226 DS--WLQGEC-----------------------QRC--SCTPEGVICEDTECAVPEAWTL 4258
Query: 712 FSEWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQECPDTLYEERECEDVSLCPVYRWKP 771
+S W+ CP C GN V+ R + PDT ++ C L W P
Sbjct: 4259 WSSWSDCPVSCGGGNQ-VRTRACRAAAPHHRSPPCLGPDTQTRQQPCP--GLLEACSWGP 4315
Query: 772 QKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCISDDNRSAEMMECLKQTNG--MPLL 829
W PC S +CG GL +R+ SC M + N + L
Sbjct: 4316 --WGPC--------------SRSCGPGLASRSGSC------PCLMAKADPTCNSTFLHLD 4353
Query: 830 VQEC-TVPCREDCTFTAWSKFTPCSTNCEATKSRRRQ---------------LTGKSRKK 873
Q C + PC E+C +++WS +T CS + R Q L G R
Sbjct: 4354 TQGCYSGPCPEECVWSSWSSWTRCSCRVLVQQRYRHQGPASRGARAGAPCTRLDGHFRPC 4413
Query: 874 --EKCQDSDLYPLVETELC---------------------PCDEFISQPYG---NWSDCI 907
C + P E C PC P G CI
Sbjct: 4414 LISNCSEDSCTPPFEFHACGSPCAGLCATHLSHQLCQDLPPCQPGCYCPKGLLEQAGGCI 4473
Query: 908 LPEGRREPHRGLRVQADSKECGEGLRFRAVACSDKNGRPVDPSFCSSSGYIQEKCVIPCP 967
PE H + G+ L+ C + G C+S G C
Sbjct: 4474 PPEECNCWHTSAAGAGMTLAPGDRLQLGCKECECRRGE----LHCTSQG---------CQ 4520
Query: 968 FDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHEAVPCYSE 1027
LS+WS W C P + P + L+
Sbjct: 4521 GLLPLSEWSEWSPCGPCL--------------PPSALAPASRTALE-------------- 4552
Query: 1028 CNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLC----NQDE 1083
EHW Q R C++ A G +LC +Q
Sbjct: 4553 --------EHWLRDPTGLSPTLAPLLASEQHRHRLCLDPATGRPWTGAPHLCTAPLSQQR 4604
Query: 1084 IPPETQSCSLMCPNECVMSEWGLWSKCPQSCDPHTMQR-RTRHLL----------RPSLN 1132
+ P+ +C P+ C S WG WS C C R R L + S N
Sbjct: 4605 LCPDPGAC----PDSCQWSLWGPWSPCQVPCSGGFRLRWREAEALCGGGCREPWAQESCN 4660
Query: 1133 SRTCAEDSQVQPCLLNENCF-QFQYNLTE-WSTCQLSENAPCGQGVRTRLLSCVCSDGKP 1190
C E + Q + +C Q ++ + W Q + PC G R V DG+
Sbjct: 4661 GGPCPE-CEAQDTVFTLDCANQCPHSCADLWDRVQCLQG-PCRPGCRCPPGQLV-QDGRC 4717
Query: 1191 VSMDQCE--------QHNLEKPQRMSIPCLVECVVN---------CQLSG-WTAWTECSQ 1232
V + C L Q + + C VN C + G W+AW+ CS
Sbjct: 4718 VPISSCRCGLPSANASWELAPAQAVQLDCQNCTCVNESLVCPHQECPVLGPWSAWSSCSA 4777
Query: 1233 TCGHGGRMSRTRFI-----IMPTQGEG---------RPCPTELTQE--KTCPVT-PCYSW 1275
CG GG M R R + P Q + +PCP + C + PC W
Sbjct: 4778 PCG-GGTMERHRTCEGGPGVAPCQAQDTEQRQECNLQPCPECPPGQVLSACATSCPCLCW 4836
Query: 1276 VLGNWSACKLE----GGDCGEGVQIRSLSCMVHSG------SISHAAGRVEDALCGEMPF 1325
L + C E G C G + + +C+ + S+ + E+P
Sbjct: 4837 HLQPGAICVQEPCQPGCGCPGGQLLHNGTCVPPTACPCTQHSLPWGLTLTLEEQAQELPP 4896
Query: 1326 QDSILKQLCSVPCPG--------DCHLTEWSEW--------STCELTCIDGRSFETVGRQ 1369
+ + C G DC + W CE TC++ + +T
Sbjct: 4897 GTVLTRNCTRCVCHGGAFSCSLVDCQVPPGETWQQVAPGELGLCEQTCLEMNATKTQSNC 4956
Query: 1370 SRSR 1373
S +R
Sbjct: 4957 SSAR 4960
Score = 124 bits (312), Expect = 6e-28
Identities = 307/1430 (21%), Positives = 453/1430 (31%), Gaps = 401/1430 (28%)
Query: 148 DCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCP-NLTESRACDAPISCPLGEE 206
DCV++ + WS+CS+ CG L + + ++ PPL GG CP + S++C +CP+
Sbjct: 2500 DCVLAPWSVWSSCSRSCGLGLTFQRQELLRPPLPGG-SCPRDRFRSQSCFVQ-ACPV--- 2554
Query: 207 EYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDSNERVTFKHQSYKAHHHSKSWAIEI 266
G W+ ++ G
Sbjct: 2555 -------AGAWAMWEAWGPCSVSCGG---------------------------------- 2573
Query: 267 GYQTRQVSCTRSDGQN--AMLSLCLQDSFPLTVQSCIMPKDCETS---------QWSSWS 315
G+Q+RQ SC +N A Q+ P +Q C DCE Q
Sbjct: 2574 GHQSRQRSCVDPPPKNGGAPCPGASQERAPCGLQPCSGGTDCELGRVYVSADLCQKGLVP 2633
Query: 316 PCSKTCR--------SGSLLPGFRSRSRNVKH-MAIGGGKECPELLEKE----------- 355
PC +C SG + G R + H ECP L+ +E
Sbjct: 2634 PCPPSCLDPKANRSCSGHCVEGCRCPPGLLLHDTRCLPLSECPCLVGEELKWPGVSFLLG 2693
Query: 356 ---ACIVE-GELLQQ---CP-RYSWRT-SEWKECQVSLLLEQQDPHWHVTGPVCGGGIQT 406
C+ E GELL Q CP W S W C S CG G++
Sbjct: 2694 NCSQCVCEKGELLCQPGGCPLPCGWSAWSSWAPCDRS----------------CGSGVRA 2737
Query: 407 REVYCAQSVPAAAALRAKEVSRPVEKALCVGPAPLPSQLCNIPCSTDCI-VSSWSAWGLC 465
R + + S P AA A C G Q C+ C T+ + W++W C
Sbjct: 2738 R--FRSPSNPPAA----------WGGAPCEGDRQ-ELQGCHTVCGTEVFGWTPWTSWSSC 2784
Query: 466 IHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVESVPCEDPMC------YRWLASEG 519
++C P G G+R+R R L S G + + PC P+C W
Sbjct: 2785 -SQSCLAPGGGPGWRSRSR--LCPSPGDSSCPGDATQEEPCSPPVCPVPSIWGLWAPWST 2841
Query: 520 ICFPDHGKCGLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSCEIPCRMDCVLSE---- 575
P G R ++ D + CP P R PC C +
Sbjct: 2842 CSAPCDGGIQTRGRSCSSLAPGD-------TTCPGPHSQTRDCNTQPCTAQCPENMLFRS 2894
Query: 576 ----WTEWSSCSQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHRLCNDHSC-M 630
E C + C + + T G CPP L C
Sbjct: 2895 AEQCHQEGGPCPRLCLTQGPGIECTGFCA-------PGCTCPPGLFLHNASCLPRSQCPC 2947
Query: 631 QLHWETSPWG------PCSEDTLVTALNA--------TIGWNG-------EATCGVGIQT 669
QLH + G C+ T V+ A GW+ +C VGI+
Sbjct: 2948 QLHGQLYASGAMARLDSCNNCTCVSGKMACTSERCPVACGWSPWTLWSLCSCSCNVGIR- 3006
Query: 670 RRVFCVKSHVGQVMTKRCPDSTRPE---TVRPCFLPCKKDCIVTAFSEWTPCPRMCQAGN 726
RR + C T ++RPC P + + W+PC C G
Sbjct: 3007 RRFRAGTAPPAAFGGAECQGPTMEAEFCSLRPCPGPGGE------WGPWSPCSVPCGGGY 3060
Query: 727 ATVKQSRYRIIIQEAANGGQECPDTLYEERECEDVSLCPVYRWKPQKWSPCILVPESVWQ 786
+ R +++ + G Q C + +CP + ++W C P S +
Sbjct: 3061 RNRTRGSSRSLMEFSTCGLQPCAGPV--------PGMCP----RDKQWLDCAQGPASCAE 3108
Query: 787 --GITGSSEACGKG--------------LQTRAVSCISDDN---------RSAEMMECLK 821
G+++ C G + T+ C + + R E C+
Sbjct: 3109 LSAPRGTNQTCHPGCHCPSGMLLLNNVCVPTQDCPCAHEGHLYPPGSTVVRPCENCSCVS 3168
Query: 822 QTNGMPLLVQECTV-PCRE-DCTFTAWSKFTPCSTNCEATKSRRRQLTGKSRKKEKCQDS 879
L+ C+ PC E + T++ W+ ++ CS +C + R + +S +
Sbjct: 3169 G------LIANCSSWPCAEGEPTWSPWTPWSQCSASCGPARCHRHRFCARSPSAVPSTVA 3222
Query: 880 DL-YPLVETELCPCDEFISQ--------------PYGNWSDCILPEGRREPHRGLRVQAD 924
L P T LC E + P+G WS C
Sbjct: 3223 PLPLPATPTPLCSGPEAEEEPCLLQGCDRAGGWGPWGPWSHC------------------ 3264
Query: 925 SKECGEGLRFRAVACSDKNGRPVDPSFCSSSGYIQEKC-VIPCPF-DCKLSDWSSWGSCS 982
S+ CG GLR R AC + + +C E C +PCP +C + + + C
Sbjct: 3265 SRSCGGGLRSRTRACDQPPPQGLG-DYCEGPRAQGEVCQALPCPVTNCTAIEGAEYSPCG 3323
Query: 983 SSC--GIGVRIRSKWLKEK----------PYNGG---RP--CPKLDLKNQAQVHEA---- 1021
C + W + NG +P C LDL + H
Sbjct: 3324 PPCPRSCDDLVHCVWRCQPGCYCPPGQVLSSNGAICVQPGHCSCLDLLTGQRHHPGARLA 3383
Query: 1022 -------------------VPCYSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIR 1062
+PC W W+ C S C G T+SR
Sbjct: 3384 RPDGCNHCTCLEGRLNCTDLPCPVPGGWCPW--SEWTMC-------SQPCRGQTRSRSRA 3434
Query: 1063 CVNTADGEGGAVDSNLCNQDEIPPETQSCS--LMCPNECVMSEWGLWSKCPQSCDPHTMQ 1120
C GGA + + + ++C CP + WG WS C
Sbjct: 3435 CACPTPQHGGAPCTGEAGEAGAQHQREACPSYATCPVDGAWGPWGPWSPCDMCLG---QS 3491
Query: 1121 RRTRHLLRP------------SLNSRTCAEDS----------QVQPCLLNENCFQFQYNL 1158
R+R RP SR C E+S + PC + C + +L
Sbjct: 3492 HRSRACSRPPTPEGGRPCPGNHTQSRPCQENSTQCTDCGGGQSLHPC--GQPCPRSCQDL 3549
Query: 1159 TEWSTCQLSE-------NAPCGQ----GVRTRLLSCVC-----SDGKPVSMDQ------C 1196
+ S CQ P GQ G+ C C + G P + +
Sbjct: 3550 SPGSVCQPGSVGCQPTCGCPLGQLSQDGLCVPPAHCRCQYQPGAMGIPENQSRSAGSRFS 3609
Query: 1197 EQHNLEKPQRMSIPC----LVECVVNCQ----------LSGWTAWTECSQTCGHGGRMSR 1242
+LE + ++ PC V ++ CQ S W W +CS +CG G ++
Sbjct: 3610 SWESLEPGEVVTGPCDNCTCVAGILQCQEVPDCPDPGVWSSWGPWEDCSVSCGGGEQLRS 3669
Query: 1243 TRFIIMPTQG---EGRPCPTELTQEKTCPVTPCYSWVLGNWSACKLEGGDC--GEGVQIR 1297
R P G + R C T++ +E CP Y +C GEG
Sbjct: 3670 RRCARPPCPGPARQSRTCSTQVCREAGCPAGRLYR--------------ECQPGEGCPFS 3715
Query: 1298 SLSCMVHSGSISHAAGRVEDALCGEMPFQDSILKQLCSVPCPGDCHLTEW 1347
G S G E C E FQ + C CP C LT W
Sbjct: 3716 CAHVTQQVGCFSE--GCEEGCHCPEGTFQHRL---ACVQECP--CVLTAW 3758
Score = 124 bits (311), Expect = 7e-28
Identities = 134/520 (25%), Positives = 191/520 (36%), Gaps = 95/520 (18%)
Query: 969 DCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHEAVPCYSEC 1028
DC L+ WS W SCS SCG+G+ + + L P GG CP+ ++Q+ +A P
Sbjct: 2500 DCVLAPWSVWSSCSRSCGLGLTFQRQELLRPPLPGG-SCPRDRFRSQSCFVQACPVAG-- 2556
Query: 1029 NQYSWVV-EHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPE 1087
+W + E W C S+ CGGG QSR+ CV+ GGA +Q+ P
Sbjct: 2557 ---AWAMWEAWGPC-------SVSCGGGHQSRQRSCVDPPPKNGGAPCPG-ASQERAPCG 2605
Query: 1088 TQSCSLMCPNE-------CVMSEWGLWSKCPQSC-DPHTMQRRTRHLLRPSLNSRTCAED 1139
Q CS E + + GL CP SC DP + + H C E
Sbjct: 2606 LQPCSGGTDCELGRVYVSADLCQKGLVPPCPPSCLDPKANRSCSGH----------CVEG 2655
Query: 1140 SQVQPCLLNENCFQFQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQH 1199
+ P LL + + C PC G + G + C Q
Sbjct: 2656 CRCPPGLLLHD-----------TRCLPLSECPCLVGEELKW------PGVSFLLGNCSQC 2698
Query: 1200 NLEKPQRMSIPCLVECVVNCQLSGWTAWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPT 1259
EK + + P C + C S W++W C ++CG G R P G PC
Sbjct: 2699 VCEKGELLCQP--GGCPLPCGWSAWSSWAPCDRSCGSGVRARFRSPSNPPAAWGGAPCEG 2756
Query: 1260 ELTQEKTCPVTPCYSWVLG-----NWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGR 1314
+ + + C T C + V G +WS+C G G RS S + S S G
Sbjct: 2757 DRQELQGCH-TVCGTEVFGWTPWTSWSSCSQSCLAPGGGPGWRSRSRLCPSPGDSSCPG- 2814
Query: 1315 VEDALCGEMPFQDSILKQLCSVP-CPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSR 1373
D+ ++ CS P CP W+ WSTC C G +T GR S
Sbjct: 2815 ------------DATQEEPCSPPVCPVPSIWGLWAPWSTCSAPCDGG--IQTRGRSCSSL 2860
Query: 1374 TFIIQSFENQDSCPQQVLETRPCTGGKCYHYTWKASLWNNNER---------TVWCQRSD 1424
+CP +TR C C + L+ + E+ + +
Sbjct: 2861 A------PGDTTCPGPHSQTRDCNTQPCTAQCPENMLFRSAEQCHQEGGPCPRLCLTQGP 2914
Query: 1425 GVNVTGGCSPQARPAAIRQCIPACRKPFSYCTQGGVCGCE 1464
G+ TG C+P C P + C C C+
Sbjct: 2915 GIECTGFCAPGC------TCPPGLFLHNASCLPRSQCPCQ 2948
Score = 122 bits (306), Expect = 3e-27
Identities = 321/1427 (22%), Positives = 450/1427 (31%), Gaps = 348/1427 (24%)
Query: 138 EQACLIP-CPRDCVVSEFLPWSNCSKGCGKKLQHRTRAV--IAPPLFGGLQCPNL-TESR 193
E+ C P CP + + PWS CS C +Q R R+ +AP G CP +++R
Sbjct: 2819 EEPCSPPVCPVPSIWGLWAPWSTCSAPCDGGIQTRGRSCSSLAP---GDTTCPGPHSQTR 2875
Query: 194 ACDAP---ISCP---LGEEEYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDS----N 243
C+ CP L + GP + L I +G +
Sbjct: 2876 DCNTQPCTAQCPENMLFRSAEQCHQEGGPCPRLCLTQGPGIECTGFCAPGCTCPPGLFLH 2935
Query: 244 ERVTFKHQSYKAHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMP 303
H + +A G R SC C+ T + C P
Sbjct: 2936 NASCLPRSQCPCQLHGQLYAS--GAMARLDSCNNCT--------CVSGKMACTSERC--P 2983
Query: 304 KDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEGEL 363
C S W+ WS CS +C G R R+ A GG + +E E C
Sbjct: 2984 VACGWSPWTLWSLCSCSCNVGIRR---RFRAGTAPPAAFGGAECQGPTMEAEFCS----- 3035
Query: 364 LQQCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRA 423
L+ CP W C V CGGG + R ++S+ +
Sbjct: 3036 LRPCPGPGGEWGPWSPCSVP----------------CGGGYRNRTRGSSRSLMEFSTCGL 3079
Query: 424 KEVSRPVEKALCVGPAPLPSQL--CNIPCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRT 481
+ + PV G P Q C ++ +S+ H CH P G
Sbjct: 3080 QPCAGPVP-----GMCPRDKQWLDCAQGPASCAELSAPRGTNQTCHPGCHCPSG---MLL 3131
Query: 482 RQRHVLMESTGPAGHCPHLVESV-----PCEDPMCYRWLASEGICFPD------------ 524
+ P H HL PCE+ C L + +P
Sbjct: 3132 LNNVCVPTQDCPCAHEGHLYPPGSTVVRPCENCSCVSGLIANCSSWPCAEGEPTWSPWTP 3191
Query: 525 ----HGKCGLGHRILKAVCQNDRGEDVSGSLCPVPPP---------PERKSCEIPCRMDC 571
CG C V ++ P+P P PE + E PC +
Sbjct: 3192 WSQCSASCGPARCHRHRFCARSPSA-VPSTVAPLPLPATPTPLCSGPEAE--EEPCLLQG 3248
Query: 572 V-----LSEWTEWSSCSQSCSNKNSDGKQTRSRTILALAGEG-GKPCPPSQALQEHRLCN 625
W WS CS+SC G ++R+R +G G C +A E +C
Sbjct: 3249 CDRAGGWGPWGPWSHCSRSCGG----GLRSRTRACDQPPPQGLGDYCEGPRAQGE--VCQ 3302
Query: 626 DHSCMQLHW------ETSPWGP-C--SEDTLVTALNATIGWNGEATC------------G 664
C + E SP GP C S D LV + W + C
Sbjct: 3303 ALPCPVTNCTAIEGAEYSPCGPPCPRSCDDLVHCV-----WRCQPGCYCPPGQVLSSNGA 3357
Query: 665 VGIQTRRVFCVKSHVGQVMTKRCPDS--TRPETVRPCF----------LPCKKDCIVTAF 712
+ +Q C+ GQ + P + RP+ C LPC +
Sbjct: 3358 ICVQPGHCSCLDLLTGQ---RHHPGARLARPDGCNHCTCLEGRLNCTDLPCPVPGGWCPW 3414
Query: 713 SEWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQECPDTLYE-----ERE-CEDVSLCPV 766
SEWT C + C+ T +SR +GG C E +RE C + CPV
Sbjct: 3415 SEWTMCSQPCRG--QTRSRSR-ACACPTPQHGGAPCTGEAGEAGAQHQREACPSYATCPV 3471
Query: 767 Y-RWKPQ-KWSPCILVPESVWQGITGSSEACGK-----------GLQTRAVSCISDDNRS 813
W P WSPC + G + S AC + G T++ C S
Sbjct: 3472 DGAWGPWGPWSPC-----DMCLGQSHRSRACSRPPTPEGGRPCPGNHTQSRPC---QENS 3523
Query: 814 AEMMECLKQTNGMPLLVQECTVPCREDCT-FTAWSKFTPCSTNCEATKSRRRQLTGKSRK 872
+ +C G + C PC C + S P S C+ T
Sbjct: 3524 TQCTDC-----GGGQSLHPCGQPCPRSCQDLSPGSVCQPGSVGCQPT------------- 3565
Query: 873 KEKCQDSDLYPLVETELCPCDEFISQPYGNWSD---CILPEGRREPHR-GLRVQADSKEC 928
C C P G S C+ P R ++ G +++
Sbjct: 3566 -----------------CGC------PLGQLSQDGLCVPPAHCRCQYQPGAMGIPENQSR 3602
Query: 929 GEGLRF---RAVACSDKNGRPVDPSFCSSSGYIQEKCVIPCPFDCKLSDWSSWGSCSSSC 985
G RF ++ + P D C + G +Q + V CP S W W CS SC
Sbjct: 3603 SAGSRFSSWESLEPGEVVTGPCDNCTCVA-GILQCQEVPDCPDPGVWSSWGPWEDCSVSC 3661
Query: 986 GIGVRIRSKWLKEKPYNGGRP--------------CPKLDLKNQAQVHEAVPCYSECNQY 1031
G G ++RS+ P G CP L + Q E P C
Sbjct: 3662 GGGEQLRSRRCARPPCPGPARQSRTCSTQVCREAGCPAGRLYRECQPGEGCPF--SCAHV 3719
Query: 1032 SWVVEHWSS-CKINNELRSLRCGGGTQSRKIRCVNTAD---------------------- 1068
+ V +S C+ C GT ++ CV
Sbjct: 3720 TQQVGCFSEGCE-----EGCHCPEGTFQHRLACVQECPCVLTAWLLQELGATIGDPGQPL 3774
Query: 1069 GEGGAVDSNL-----CNQDEIPPETQSCSLMCPNECVMSE-----WGLWSKCPQSCDPHT 1118
G G +DS C SCSL ++C ++ W W C +SC
Sbjct: 3775 GPGDELDSGQTLRTSCGNCSCAHGKLSCSL---DDCFEADGGFGPWSPWGPCSRSCGGLG 3831
Query: 1119 MQRRTRH--LLRPSLNSRTCAEDSQVQPCLLNENCFQFQYNLTE--------------WS 1162
+ R+R L P+L+ + C Q C + +C + + E WS
Sbjct: 3832 TRTRSRQCVLTMPTLSGQGCRGPRQDLECP-SPDCPGAEGSTVEPVTGLPGGWGPWSSWS 3890
Query: 1163 TCQLSENAPCGQGVRTRLLSCV--CSDGKPVSMDQCEQHNLEKPQRMSIPCLVECVV-NC 1219
C S P R+R C+ C+ G P+ C NL + + C NC
Sbjct: 3891 PCSRSCTDPARPAWRSRTRLCLANCTMGDPLQERPC---NLPSCTELPVCPGPGCGAGNC 3947
Query: 1220 QLSGWTAWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPTELT--QEK------TCPVTP 1271
+ W W CS++CG G + R R P G G CP LT QE+ CPV
Sbjct: 3948 SWTSWAPWEPCSRSCGVG-QQRRLRAYRPPGPG-GHWCPNILTAYQERRFCNLRACPVPG 4005
Query: 1272 CYSWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSILK 1331
+S WS CG G +RS SC S S G
Sbjct: 4006 GWS----RWSPWSWCDRSCGGGQSLRSRSC---SSPPSKNGG------------------ 4040
Query: 1332 QLCSVPCPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQ 1378
PC G+ H CE C G T + R +Q
Sbjct: 4041 ----APCAGERHQARLCNPMPCEAGCPAGMEVVTCANRCPRRCSDLQ 4083
Score = 99.0 bits (245), Expect = 3e-20
Identities = 206/913 (22%), Positives = 293/913 (32%), Gaps = 243/913 (26%)
Query: 516 ASEGICFPDHGKCGLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSCEIPCRMDCVLSE 575
AS +C P CG G + + C + P + S E C +DCVL+
Sbjct: 2459 ASRALCSPSQLSCGSGECLS------------AERRCDLRPDCQDGSDEDGC-VDCVLAP 2505
Query: 576 WTEWSSCSQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHRLCNDHSC----MQ 631
W+ WSSCS+SC + +Q R L G CP + + C +C
Sbjct: 2506 WSVWSSCSRSCGLGLTFQRQELLRPPLP-----GGSCPRDRFRSQS--CFVQACPVAGAW 2558
Query: 632 LHWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDST 691
WE WGPCS +CG G Q+R+ CV CP ++
Sbjct: 2559 AMWEA--WGPCS-----------------VSCGGGHQSRQRSCVDPPPKNGGAP-CPGAS 2598
Query: 692 RPETVRPCFL-PCK--KDC-----IVTA----FSEWTPCPRMCQAGNATVKQSRYRIIIQ 739
+ PC L PC DC V+A PCP C A R
Sbjct: 2599 QERA--PCGLQPCSGGTDCELGRVYVSADLCQKGLVPPCPPSCLDPKAN------RSCSG 2650
Query: 740 EAANGGQECPDTLYEERECEDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGL 799
G + P L + C +S C PC++ E W G++ C +
Sbjct: 2651 HCVEGCRCPPGLLLHDTRCLPLSEC-----------PCLVGEELKWPGVSFLLGNCSQ-- 2697
Query: 800 QTRAVSCISDDNRSAEMMECLKQTNGMPLLVQECTVPCREDCTFTAWSKFTPCSTNC-EA 858
C+ E E L Q G PL C ++AWS + PC +C
Sbjct: 2698 ------CV------CEKGELLCQPGGCPL-----------PCGWSAWSSWAPCDRSCGSG 2734
Query: 859 TKSRRRQLTGKSRK--KEKCQDSDLYPLVETELCPCDEFISQPYGNWS----DCILPEGR 912
++R R + C+ +C + F P+ +WS C+ P G
Sbjct: 2735 VRARFRSPSNPPAAWGGAPCEGDRQELQGCHTVCGTEVFGWTPWTSWSSCSQSCLAPGG- 2793
Query: 913 REPHRGLRVQADSKECGEGLRFRAVACSDKNGRPVDPSFCSSSGYIQEKCVIP-CPFDCK 971
G G R R+ C P D S C +E C P CP
Sbjct: 2794 ----------------GPGWRSRSRLCPS----PGDSS-CPGDATQEEPCSPPVCPVPSI 2832
Query: 972 LSDWSSWGSCSSSCGIGVRIRSKWLK---------------------------------- 997
W+ W +CS+ C G++ R +
Sbjct: 2833 WGLWAPWSTCSAPCDGGIQTRGRSCSSLAPGDTTCPGPHSQTRDCNTQPCTAQCPENMLF 2892
Query: 998 ---EKPYNGGRPCPKLDLKNQAQVHEAVPCYSECNQYSWVVEHWSSCKINNELRSLRCGG 1054
E+ + G PCP+L L + C C + H +SC L +C
Sbjct: 2893 RSAEQCHQEGGPCPRLCLTQGPGIECTGFCAPGCTCPPGLFLHNASC-----LPRSQCPC 2947
Query: 1055 GTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQSC-SLMCPNECVMSEWGLWSKCPQS 1113
+ A G +DS CN +C S CP C S W LWS C S
Sbjct: 2948 QLHGQLY-----ASGAMARLDS--CNNCTCVSGKMACTSERCPVACGWSPWTLWSLCSCS 3000
Query: 1114 CDPHTMQRRTRHLLRP--SLNSRTC------AEDSQVQPCLLNENCFQFQYNLTEWSTCQ 1165
C+ ++RR R P + C AE ++PC WS C
Sbjct: 3001 CNV-GIRRRFRAGTAPPAAFGGAECQGPTMEAEFCSLRPCPGPGG------EWGPWSPC- 3052
Query: 1166 LSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHNLEKPQRMSIPCLVECVVNCQLSGWT 1225
+ PCG G R R + G S+ + L+ PC C
Sbjct: 3053 ---SVPCGGGYRNR------TRGSSRSLMEFSTCGLQ-------PCAGPVPGMCPRD--K 3094
Query: 1226 AWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPTELTQEKTCPVTPCYSWVLGNWSACKL 1285
W +C+Q +S R G + C P C S +L + C
Sbjct: 3095 QWLDCAQGPASCAELSAPR-------GTNQTCH---------PGCHCPSGMLLLNNVC-- 3136
Query: 1286 EGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSILKQLCSVPC-PGDCHL 1344
V + C H G + + G C ++ S PC G+
Sbjct: 3137 --------VPTQDCPC-AHEGHL-YPPGSTVVRPCENCSCVSGLIANCSSWPCAEGEPTW 3186
Query: 1345 TEWSEWSTCELTC 1357
+ W+ WS C +C
Sbjct: 3187 SPWTPWSQCSASC 3199
Score = 96.3 bits (238), Expect = 2e-19
Identities = 326/1510 (21%), Positives = 473/1510 (31%), Gaps = 409/1510 (27%)
Query: 145 CPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPL-FGGLQCP-NLTESRACDAPISCP 202
CP C S + W+ C + CG ++ R R+ PP +GG C + E + C
Sbjct: 2712 CPLPCGWSAWSSWAPCDRSCGSGVRARFRSPSNPPAAWGGAPCEGDRQELQGCHTVC--- 2768
Query: 203 LGEEEYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDSNERVTFKHQSYKAHHHSKSW 262
G E + ++ PW+ + P G
Sbjct: 2769 -GTEVFGWT----PWTSWSSCSQSCLAPGGGP---------------------------- 2795
Query: 263 AIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCETSQWSSWSPCSKTCR 322
G+++R C S G ++ Q+ P + C +P W+ WS CS C
Sbjct: 2796 ----GWRSRSRLCP-SPGDSSCPGDATQEE-PCSPPVCPVPSIW--GLWAPWSTCSAPCD 2847
Query: 323 SG---------------SLLPGFRSRSRNVKHMAIGGGKECPELL---EKEACIVEGELL 364
G + PG S++R+ +CPE + E C EG
Sbjct: 2848 GGIQTRGRSCSSLAPGDTTCPGPHSQTRDCNTQPCTA--QCPENMLFRSAEQCHQEGG-- 2903
Query: 365 QQCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAK 424
CPR EC + G C G+ C L +
Sbjct: 2904 -PCPRLCLTQGPGIECT----------GFCAPGCTCPPGLFLHNASCLPRSQCPCQLHGQ 2952
Query: 425 EVSRPVEKAL-------CV-GPAPLPSQLCNIPCSTDCIVSSWSAWGLCIHENCHDPQGK 476
+ L CV G S+ C + C S W+ W LC +C
Sbjct: 2953 LYASGAMARLDSCNNCTCVSGKMACTSERCPVACGW----SPWTLWSLC---SC---SCN 3002
Query: 477 KGFRTRQRHVLMESTGPAGHCPHLVESVPCEDPMCYRWLASEGICFPDHGK--------- 527
G R R R T P P C+ P S C G+
Sbjct: 3003 VGIRRRFR----AGTAP----PAAFGGAECQGPTMEAEFCSLRPCPGPGGEWGPWSPCSV 3054
Query: 528 -CGLGHRILKAVCQNDRGEDVS---GSLCPVPPPPERKSCEIPCRMDCVLSEWTEWSSCS 583
CG G+R RG S S C + P C P C + +W C+
Sbjct: 3055 PCGGGYR------NRTRGSSRSLMEFSTCGLQP------CAGPVPGMCPRDK--QWLDCA 3100
Query: 584 Q---SCSNKNSDGKQTRSRTILALAGEG----GKPCPPSQ----ALQEH---------RL 623
Q SC+ ++ ++ G C P+Q A + H R
Sbjct: 3101 QGPASCAELSAPRGTNQTCHPGCHCPSGMLLLNNVCVPTQDCPCAHEGHLYPPGSTVVRP 3160
Query: 624 CNDHSCMQ-LHWETSPWGPCSEDTLVTALNATIGWNG-EATCGVGIQTRRVFCVKSHVGQ 681
C + SC+ L S W PC+E + W+ A+CG R FC +S
Sbjct: 3161 CENCSCVSGLIANCSSW-PCAEGE--PTWSPWTPWSQCSASCGPARCHRHRFCARS---- 3213
Query: 682 VMTKRCPDSTRPETVRPCFLPC------------KKDCIVTA---------FSEWTPCPR 720
S P TV P LP ++ C++ + W+ C R
Sbjct: 3214 -------PSAVPSTVAPLPLPATPTPLCSGPEAEEEPCLLQGCDRAGGWGPWGPWSHCSR 3266
Query: 721 MCQAGNATVKQSRYRIIIQEAANG-GQECPDTLYEERECEDVSLCPVYRW---KPQKWSP 776
C G +SR R Q G G C + C+ + CPV + ++SP
Sbjct: 3267 SCGGG----LRSRTRACDQPPPQGLGDYCEGPRAQGEVCQALP-CPVTNCTAIEGAEYSP 3321
Query: 777 C-ILVPES-------VWQGITGSSEACGKGLQTRAVSCISDDNRSA-EMMECLKQTNGMP 827
C P S VW+ G G+ L + C+ + S +++ + G
Sbjct: 3322 CGPPCPRSCDDLVHCVWRCQPGCYCPPGQVLSSNGAICVQPGHCSCLDLLTGQRHHPGAR 3381
Query: 828 LL----VQECT----------VPCREDCTFTAWSKFTPCSTNCEA-TKSRRRQL------ 866
L CT +PC + WS++T CS C T+SR R
Sbjct: 3382 LARPDGCNHCTCLEGRLNCTDLPCPVPGGWCPWSEWTMCSQPCRGQTRSRSRACACPTPQ 3441
Query: 867 ------TGKSRKKEKCQDSDLYPLVETELCPCDEFISQPYGNWSDCIL------------ 908
TG++ + + P T CP D P+G WS C +
Sbjct: 3442 HGGAPCTGEAGEAGAQHQREACPSYAT--CPVDGAWG-PWGPWSPCDMCLGQSHRSRACS 3498
Query: 909 ----PEGRREPHRGLRVQA--------DSKECGEGLRFRAV------ACSDKNGRPV--- 947
PEG R P G Q+ +CG G +C D + V
Sbjct: 3499 RPPTPEGGR-PCPGNHTQSRPCQENSTQCTDCGGGQSLHPCGQPCPRSCQDLSPGSVCQP 3557
Query: 948 -----DPSFCSSSGYIQEK--CVIPCPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKP 1000
P+ G + + CV P C+ + + S G R S E
Sbjct: 3558 GSVGCQPTCGCPLGQLSQDGLCVPPAHCRCQYQPGAMGIPENQSRSAGSRFSSWESLEPG 3617
Query: 1001 YNGGRPCPKLD-LKNQAQVHEAVPCYSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSR 1059
PC + Q E C SW W C ++ CGGG Q R
Sbjct: 3618 EVVTGPCDNCTCVAGILQCQEVPDCPDPGVWSSW--GPWEDCSVS-------CGGGEQLR 3668
Query: 1060 KIRCVNTADGEGGAVDSNLCNQDEIPPETQSC-SLMCPNECVMSEWGLWSKCPQSCDPHT 1118
RC G A S C+ TQ C CP + E CP SC T
Sbjct: 3669 SRRCARPPC-PGPARQSRTCS-------TQVCREAGCPAGRLYRECQPGEGCPFSCAHVT 3720
Query: 1119 MQRRTRHLLRPSLNSRTCAEDSQVQPCLLNENCFQFQYNLTEWSTCQLS----------- 1167
Q C + + C E FQ + + C L+
Sbjct: 3721 QQVG-------------CFSEGCEEGCHCPEGTFQHRLACVQECPCVLTAWLLQELGATI 3767
Query: 1168 ----------ENAPCGQGVRTRLLSCVCSDGK-PVSMDQCEQHNLEKPQRMSIPCLVECV 1216
+ GQ +RT +C C+ GK S+D C +
Sbjct: 3768 GDPGQPLGPGDELDSGQTLRTSCGNCSCAHGKLSCSLDDCFE------------------ 3809
Query: 1217 VNCQLSGWTAWTECSQTCGHGGRMSRTR--FIIMPT-QGEGRPCPTELTQEKTCPVTPCY 1273
+ W+ W CS++CG G +R+R + MPT G+G P Q+ CP C
Sbjct: 3810 ADGGFGPWSPWGPCSRSCGGLGTRTRSRQCVLTMPTLSGQGCRGP---RQDLECPSPDCP 3866
Query: 1274 SWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALC-GEMPFQDSILKQ 1332
+ + G G G C + A R LC D + ++
Sbjct: 3867 G--AEGSTVEPVTGLPGGWGPWSSWSPCSRSCTDPARPAWRSRTRLCLANCTMGDPLQER 3924
Query: 1333 LCSVP-------CP------GDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTF---- 1375
C++P CP G+C T W+ W C +C VG+Q R R +
Sbjct: 3925 PCNLPSCTELPVCPGPGCGAGNCSWTSWAPWEPCSRSC-------GVGQQRRLRAYRPPG 3977
Query: 1376 --------IIQSFENQDSCPQQVLETRPCTGGKCYHYTWKASLWNNNERTVWCQRSDGVN 1427
I+ +++ + C L P GG W+ WC RS G
Sbjct: 3978 PGGHWCPNILTAYQERRFCN---LRACPVPGG-----------WSRWSPWSWCDRSCG-- 4021
Query: 1428 VTGGCSPQAR 1437
GG S ++R
Sbjct: 4022 --GGQSLRSR 4029
Score = 78.2 bits (191), Expect = 6e-14
Identities = 201/914 (21%), Positives = 276/914 (30%), Gaps = 261/914 (28%)
Query: 145 CPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLF-GGLQCPNLT-ESRACD---API 199
CP S + PWS C + CG R+R+ +PP GG C ++R C+
Sbjct: 4001 CPVPGGWSRWSPWSWCDRSCGGGQSLRSRSCSSPPSKNGGAPCAGERHQARLCNPMPCEA 4060
Query: 200 SCPLGEEEYTFS---------LKVGPWSK--------CRLPHLKEINPSGRTVLDFNSDS 242
CP G E T + L+ G + CR P + G V + D
Sbjct: 4061 GCPAGMEVVTCANRCPRRCSDLQEGIVCQDDQVCQKGCRCPK-GSLEQDGGCVPIGHCDC 4119
Query: 243 NERVTFKHQSYKAHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIM 302
+ A HS WA +Q +C+ GQ T Q C
Sbjct: 4120 TD----------AQGHS--WAPGSQHQDACNNCSCQAGQ-----------LSCTAQPCPP 4156
Query: 303 PKDCETSQWSSWSPCSKTC------------RSGSLLPGFR------------------- 331
P C S WS+WSPCS +C SGS P R
Sbjct: 4157 PTHCAWSHWSAWSPCSHSCGPRGQQSRFRSSTSGSWAPECREEQSQSQPCPQPSCPPLCL 4216
Query: 332 --SRSRNVKHMAIGGGKECPELLEKEACIVEGELLQ--QC--PRYSWRTSEWKECQVSL- 384
+RSR + + G EC ++ +C EG + + +C P S W +C VS
Sbjct: 4217 QGTRSRTLGDSWLQG--EC----QRCSCTPEGVICEDTECAVPEAWTLWSSWSDCPVSCG 4270
Query: 385 --------LLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKALCV 436
PH H + P G QTR+ C + A + SR L
Sbjct: 4271 GGNQVRTRACRAAAPH-HRSPPCLGPDTQTRQQPCPGLLEACSWGPWGPCSRSCGPGLAS 4329
Query: 437 GPAPLPSQL------CNI-------------PCSTDCIVSSWSAWGLCIHENCHDPQGK- 476
P + CN PC +C+ SSWS+W C + +
Sbjct: 4330 RSGSCPCLMAKADPTCNSTFLHLDTQGCYSGPCPEECVWSSWSSWTRCSCRVLVQQRYRH 4389
Query: 477 KGFRTRQRHVLMESTGPAGHC-PHLVESVPCEDPMCYRWLASEGICFPDHGKCG--LGHR 533
+G +R T GH P L+ + C + C P G C L H+
Sbjct: 4390 QGPASRGARAGAPCTRLDGHFRPCLISN--CSEDSCTPPFEFHACGSPCAGLCATHLSHQ 4447
Query: 534 ILKAV--------CQNDRGEDVSGSLCPVPPPPERKSC---------------------- 563
+ + + C E G + PPE +C
Sbjct: 4448 LCQDLPPCQPGCYCPKGLLEQAGGCI-----PPEECNCWHTSAAGAGMTLAPGDRLQLGC 4502
Query: 564 -EIPCR---MDCV---------LSEWTEWSSCSQSCSNKNSDGKQTRSRTILALAGEGGK 610
E CR + C LSEW+EWS C
Sbjct: 4503 KECECRRGELHCTSQGCQGLLPLSEWSEWSPCG--------------------------- 4535
Query: 611 PCPPSQALQEHRLCNDHSCMQLHWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTR 670
PC P AL + ++ HW P T L+ T+ A Q R
Sbjct: 4536 PCLPPSALAPA----SRTALEEHWLRDP----------TGLSPTL-----APLLASEQHR 4576
Query: 671 RVFCVKSHVGQVMTKRCPDSTRP-ETVRPCFLP--CKKDCIVTAFSEWTPCPRMCQAGNA 727
C+ G+ T T P R C P C C + + W+PC C G
Sbjct: 4577 HRLCLDPATGRPWTGAPHLCTAPLSQQRLCPDPGACPDSCQWSLWGPWSPCQVPCSGGFR 4636
Query: 728 TVKQSRYRII--------IQEAANGGQECPDTLYEERECEDVSLCPVYRWKPQKWSPCIL 779
+ + QE+ NGG CP ECE Q C
Sbjct: 4637 LRWREAEALCGGGCREPWAQESCNGGP-CP-------ECEAQDTVFTLDCANQCPHSCA- 4687
Query: 780 VPESVWQGITGSSEACGKGLQTRAVSCISDDNRSAEMMEC------------LKQTNGMP 827
+W + C G + + D R + C L +
Sbjct: 4688 ---DLWDRVQCLQGPCRPGCRCPPGQLVQD-GRCVPISSCRCGLPSANASWELAPAQAVQ 4743
Query: 828 LLVQECTV-------PCREDCTFTAWSKFTPCSTNCEATKSRRRQLTGKSRKKEKCQDSD 880
L Q CT P +E WS ++ CS C R + CQ D
Sbjct: 4744 LDCQNCTCVNESLVCPHQECPVLGPWSAWSSCSAPCGGGTMERHRTCEGGPGVAPCQAQD 4803
Query: 881 LYPLVETELCPCDE 894
E L PC E
Sbjct: 4804 TEQRQECNLQPCPE 4817
Score = 66.6 bits (161), Expect = 2e-10
Identities = 138/566 (24%), Positives = 186/566 (32%), Gaps = 118/566 (20%)
Query: 139 QACLIP-CPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVI-APPLFGGLQCPNLTESRA-- 194
Q+C + CP + + W CS CG Q R R+ + PP GG CP ++ RA
Sbjct: 2545 QSCFVQACPVAGAWAMWEAWGPCSVSCGGGHQSRQRSCVDPPPKNGGAPCPGASQERAPC 2604
Query: 195 ----CDAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDSNERVTFKH 250
C C LG + L C+ + PS LD ++ +
Sbjct: 2605 GLQPCSGGTDCELGRVYVSADL-------CQKGLVPPCPPS---CLDPKANRS------- 2647
Query: 251 QSYKAHHHSKSWAIEIGYQTRQVSC-------------TRSDGQNAMLSLCLQ---DSFP 294
+ H + G C + G + +L C Q +
Sbjct: 2648 ---CSGHCVEGCRCPPGLLLHDTRCLPLSECPCLVGEELKWPGVSFLLGNCSQCVCEKGE 2704
Query: 295 LTVQSCIMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECP-ELLE 353
L Q P C S WSSW+PC ++C SG + FRS S A GG C + E
Sbjct: 2705 LLCQPGGCPLPCGWSAWSSWAPCDRSCGSG-VRARFRSPS---NPPAAWGGAPCEGDRQE 2760
Query: 354 KEAC--IVEGELLQQCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGG-------GI 404
+ C + E+ P W + W C S L P W +C G
Sbjct: 2761 LQGCHTVCGTEVFGWTP---W--TSWSSCSQSCLAPGGGPGWRSRSRLCPSPGDSSCPGD 2815
Query: 405 QTREVYCAQ---SVPAAAALRA--KEVSRPVEKAL----------------CVGPAPLPS 443
T+E C+ VP+ L A S P + + C GP
Sbjct: 2816 ATQEEPCSPPVCPVPSIWGLWAPWSTCSAPCDGGIQTRGRSCSSLAPGDTTCPGPHSQTR 2875
Query: 444 QLCNIPCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTG---PAGHCPHL 500
PC+ C + E CH G + +E TG P CP
Sbjct: 2876 DCNTQPCTAQCPENMLFRSA----EQCHQEGGPCPRLCLTQGPGIECTGFCAPGCTCP-- 2929
Query: 501 VESVPCEDPMCYRWLASEGICFP-DHGKCGLGHRILKAVCQNDRGEDVSGSLCPVPPPPE 559
P + AS C P C L H L A R + + C
Sbjct: 2930 --------PGLFLHNAS---CLPRSQCPCQL-HGQLYASGAMARLDSCNNCTC----VSG 2973
Query: 560 RKSCEIP-CRMDCVLSEWTEWSSCSQSCSNKNSDGKQTRSRTILA-LAGEGGKPCPPSQA 617
+ +C C + C S WT WS CS SC + G + R R A A GG C
Sbjct: 2974 KMACTSERCPVACGWSPWTLWSLCSCSC----NVGIRRRFRAGTAPPAAFGGAEC--QGP 3027
Query: 618 LQEHRLCNDHSCMQLHWETSPWGPCS 643
E C+ C E PW PCS
Sbjct: 3028 TMEAEFCSLRPCPGPGGEWGPWSPCS 3053
Score = 60.5 bits (145), Expect = 1e-08
Identities = 77/313 (24%), Positives = 113/313 (36%), Gaps = 63/313 (20%)
Query: 975 WSSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHEAVPCYSECNQYSWV 1034
WS WG CS +CG + RS+ + CP + ++QA A P E + +S
Sbjct: 1700 WSPWGPCSRTCGPWGQGRSRRCSPLGLLVLQNCPGPEHQSQACFTAACPVDGEWSTWS-- 1757
Query: 1035 VEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEG--GAVDSNLCNQDEIPPETQSCS 1092
WS C S C G T +R+ +C + +G A+ L + + P Q
Sbjct: 1758 --PWSVC-------SEPCRG-TMTRQRQCHSPQNGGRTCAALPGGLHSTRQTKPCPQDG- 1806
Query: 1093 LMCPNECVMSE--WGLWSKCPQSCDPHTMQRRTRHLLRPSLNSRTCAEDSQVQPCLLNEN 1150
CPN E + + CP +CD + Q TC D PC +
Sbjct: 1807 --CPNATCSGELMFQPCAPCPLTCDDISGQV-------------TCPPD---WPCG-SPG 1847
Query: 1151 CFQFQYN-LTEWSTCQLSENAPC---------GQGVRTRLLSCVCSDGKPVSMDQCEQHN 1200
C+ + L C PC GQ ++ C+C DG+P +C +
Sbjct: 1848 CWCPEGQVLGSEGWCVWPRQCPCLVDGARYWPGQRIKADCQLCICQDGRP---RRCRLNP 1904
Query: 1201 LEKPQRMSIPCLVECVVNCQLSGWTAWTECSQTCGHGGRMSRTRFIIMP-TQGEGRPCPT 1259
+C V+C S W+ W +C CG R P G GR C
Sbjct: 1905 -------------DCAVDCGWSSWSPWAKCLGPCGSQSIQWSFRSSNNPRPSGRGRQCRG 1951
Query: 1260 ELTQEKTCPVTPC 1272
+ + C PC
Sbjct: 1952 IHRKARRCQTEPC 1964
Score = 54.7 bits (130), Expect = 7e-07
Identities = 43/164 (26%), Positives = 64/164 (39%), Gaps = 27/164 (16%)
Query: 1217 VNCQLSGWTAWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPTELTQEKTCPVTPC---Y 1273
V+C L+ W+ W+ CS++CG G R + P G CP + + ++C V C
Sbjct: 2499 VDCVLAPWSVWSSCSRSCGLGLTFQRQELLRPPLPGGS--CPRDRFRSQSCFVQACPVAG 2556
Query: 1274 SWVLGN-WSACKLEGGDCGEGVQIRSLSCM---VHSGSISHAAGRVEDALCGEMPFQDS- 1328
+W + W C + CG G Q R SC+ +G E A CG P
Sbjct: 2557 AWAMWEAWGPCSV---SCGGGHQSRQRSCVDPPPKNGGAPCPGASQERAPCGLQPCSGGT 2613
Query: 1329 --------ILKQLCS----VPCPGDCHLTEWSEWSTCELTCIDG 1360
+ LC PCP C + +C C++G
Sbjct: 2614 DCELGRVYVSADLCQKGLVPPCPPSC--LDPKANRSCSGHCVEG 2655
Score = 50.8 bits (120), Expect = 1e-05
Identities = 77/332 (23%), Positives = 105/332 (31%), Gaps = 87/332 (26%)
Query: 769 WKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCISDDNRSAEMMECLKQTNGMPL 828
W P W PC S CG Q R+ C S + L+ G
Sbjct: 1700 WSP--WGPC--------------SRTCGPWGQGRSRRC------SPLGLLVLQNCPGPEH 1737
Query: 829 LVQEC-TVPCREDCTFTAWSKFTPCSTNCEATKSRRRQLTGKSRKKEKCQ--DSDLYPLV 885
Q C T C D ++ WS ++ CS C T +R+RQ C L+
Sbjct: 1738 QSQACFTAACPVDGEWSTWSPWSVCSEPCRGTMTRQRQCHSPQNGGRTCAALPGGLHSTR 1797
Query: 886 ETELCP------------------------CDEFISQ-------PYGNWSDCILPEGRRE 914
+T+ CP CD+ Q P G+ C PEG+
Sbjct: 1798 QTKPCPQDGCPNATCSGELMFQPCAPCPLTCDDISGQVTCPPDWPCGS-PGCWCPEGQVL 1856
Query: 915 PHRGLRVQADSKEC---------GEGLRFRAVACSDKNGRPVDPSFCSSSGYIQEKCVI- 964
G V C G+ ++ C ++GRP +C +
Sbjct: 1857 GSEGWCVWPRQCPCLVDGARYWPGQRIKADCQLCICQDGRP-------------RRCRLN 1903
Query: 965 -PCPFDCKLSDWSSWGSCSSSCG---IGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHE 1020
C DC S WS W C CG I RS +P GR C + K + E
Sbjct: 1904 PDCAVDCGWSSWSPWAKCLGPCGSQSIQWSFRSS-NNPRPSGRGRQCRGIHRKARRCQTE 1962
Query: 1021 AVPCYSECNQYSWVVEHW--SSCKINNELRSL 1050
Q V E W C++ L +L
Sbjct: 1963 PCEGCEHQGQVHRVGERWHGGPCRVCQCLHNL 1994
Score = 49.7 bits (117), Expect = 2e-05
Identities = 83/360 (23%), Positives = 114/360 (31%), Gaps = 100/360 (27%)
Query: 544 GEDVSGSLCPVPPPPERKSCEIPCRMDCVLSEWTEWSSCSQSCSNKNSDGKQTRSRTILA 603
G+ G V P PE + C W+ W CS++C Q RSR
Sbjct: 1675 GQPDCGRPGQVGPSPEEQGCG-------AWGPWSPWGPCSRTC----GPWGQGRSRRCSP 1723
Query: 604 LAGEGGKPCPPSQALQEHRLCNDHSC-MQLHWET-SPWGPCSE---DTLVTALNATIGWN 658
L + CP + + + C +C + W T SPW CSE T+ N
Sbjct: 1724 LGLLVLQNCPGPE--HQSQACFTAACPVDGEWSTWSPWSVCSEPCRGTMTRQRQCHSPQN 1781
Query: 659 GEATCGV---GIQTRRVFCVKSHVGQVMTKRCPDSTRPETVRPCFLPCKKDCIVTAFSEW 715
G TC G+ + R TK CP P C + + F
Sbjct: 1782 GGRTCAALPGGLHSTR-----------QTKPCPQDGCPNAT------CSGELM---FQPC 1821
Query: 716 TPCPRMCQ--AGNATVKQSRYRIIIQEAANGGQECPD--TLYEERECEDVSLCPVYRWKP 771
PCP C +G T + G CP+ L E C W
Sbjct: 1822 APCPLTCDDISGQVTCPPD------WPCGSPGCWCPEGQVLGSEGWCV---------WPR 1866
Query: 772 QKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCISDDNRSAEMMECLKQTNGMPLLVQ 831
Q PC++ W G+ ++ CI D R L
Sbjct: 1867 Q--CPCLVDGARYWP---------GQRIKADCQLCICQDGRPRRCR-----------LNP 1904
Query: 832 ECTVPCREDCTFTAWSKFTPC--------------STNCEATKSRRRQLTGKSRKKEKCQ 877
+C V DC +++WS + C S+N R RQ G RK +CQ
Sbjct: 1905 DCAV----DCGWSSWSPWAKCLGPCGSQSIQWSFRSSNNPRPSGRGRQCRGIHRKARRCQ 1960
Score = 47.0 bits (110), Expect = 1e-04
Identities = 51/192 (26%), Positives = 66/192 (34%), Gaps = 45/192 (23%)
Query: 303 PKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPEL----------- 351
P D E S WS WS CS+ CR G +R R H GG+ C L
Sbjct: 1748 PVDGEWSTWSPWSVCSEPCR------GTMTRQRQC-HSPQNGGRTCAALPGGLHSTRQTK 1800
Query: 352 -LEKEAC---IVEGELLQQ----CPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVC--- 400
++ C GEL+ Q CP S C P W P C
Sbjct: 1801 PCPQDGCPNATCSGELMFQPCAPCPLTCDDISGQVTC---------PPDWPCGSPGCWCP 1851
Query: 401 GGGIQTREVYCAQS------VPAAAALRAKEVSRPVEKALCVGPAPLPSQLCNIPCSTDC 454
G + E +C V A + + + +C P +L N C+ DC
Sbjct: 1852 EGQVLGSEGWCVWPRQCPCLVDGARYWPGQRIKADCQLCICQDGRPRRCRL-NPDCAVDC 1910
Query: 455 IVSSWSAWGLCI 466
SSWS W C+
Sbjct: 1911 GWSSWSPWAKCL 1922
Score = 45.4 bits (106), Expect = 4e-04
Identities = 64/263 (24%), Positives = 88/263 (33%), Gaps = 57/263 (21%)
Query: 1136 CAEDSQVQPCLLNENCFQFQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQ 1195
C QV P + C + + W C + P GQG R CS + +
Sbjct: 1679 CGRPGQVGPSPEEQGCGAWG-PWSPWGPCSRT-CGPWGQGRSRR-----CSPLGLLVLQN 1731
Query: 1196 CEQHNLEKPQRMSIPCLVE-CVVNCQLSGWTAWTECSQTCGHGGRMSRTRFIIMPTQG-- 1252
C P+ S C C V+ + S W+ W+ CS+ C G M+R R P G
Sbjct: 1732 CPG-----PEHQSQACFTAACPVDGEWSTWSPWSVCSEPCR--GTMTRQRQCHSPQNGGR 1784
Query: 1253 -------------EGRPCPTELTQEKTC-------PVTPCY--------------SWVLG 1278
+ +PCP + TC P PC W G
Sbjct: 1785 TCAALPGGLHSTRQTKPCPQDGCPNATCSGELMFQPCAPCPLTCDDISGQVTCPPDWPCG 1844
Query: 1279 NWSACKLEG---GDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSILKQLCS 1335
+ EG G G V R C+V + G+ A C QD ++
Sbjct: 1845 SPGCWCPEGQVLGSEGWCVWPRQCPCLVDGAR--YWPGQRIKADCQLCICQDGRPRRCRL 1902
Query: 1336 VP-CPGDCHLTEWSEWSTCELTC 1357
P C DC + WS W+ C C
Sbjct: 1903 NPDCAVDCGWSSWSPWAKCLGPC 1925
Score = 43.1 bits (100), Expect = 0.002
Identities = 74/302 (24%), Positives = 97/302 (32%), Gaps = 94/302 (31%)
Query: 311 WSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECP------ELLEKEACIVEGELL 364
WS W PCS+TC P + RSR + + + CP + AC V+GE
Sbjct: 1700 WSPWGPCSRTCG-----PWGQGRSRRCSPLGLLVLQNCPGPEHQSQACFTAACPVDGE-- 1752
Query: 365 QQCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYC---AQSVPAAAAL 421
W T W W V C G TR+ C AAL
Sbjct: 1753 -------WST--WSP-------------WSVCSEPC-RGTMTRQRQCHSPQNGGRTCAAL 1789
Query: 422 RAKEVSRPVEKALCVGPAPLPSQLC-NIPCSTDCIVSSWSAWGLCIHENCHDPQGKKGFR 480
S K P P C N CS + + + L C D G+
Sbjct: 1790 PGGLHSTRQTK-------PCPQDGCPNATCSGELMFQPCAPCPL----TCDDISGQV--- 1835
Query: 481 TRQRHVLMESTGPAGHCPHLVESVPCEDPMCY----RWLASEG--------ICFPDHGKC 528
CP PC P C+ + L SEG C D +
Sbjct: 1836 ---------------TCP---PDWPCGSPGCWCPEGQVLGSEGWCVWPRQCPCLVDGARY 1877
Query: 529 GLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSCEIPCRMDCVLSEWTEWSSCSQSCSN 588
G RI KA CQ +D C + P C +DC S W+ W+ C C +
Sbjct: 1878 WPGQRI-KADCQLCICQDGRPRRCRLNP---------DCAVDCGWSSWSPWAKCLGPCGS 1927
Query: 589 KN 590
++
Sbjct: 1928 QS 1929
Score = 37.7 bits (86), Expect = 0.088
Identities = 94/397 (23%), Positives = 133/397 (33%), Gaps = 106/397 (26%)
Query: 139 QACLIP-CPRDCVVSEFLPWSNCSKGCGKKL---------QHRTRAVIAPPLFGGLQ--- 185
QAC CP D S + PWS CS+ C + Q+ R A P GGL
Sbjct: 1740 QACFTAACPVDGEWSTWSPWSVCSEPCRGTMTRQRQCHSPQNGGRTCAALP--GGLHSTR 1797
Query: 186 ---------CPNLTES-----RACDAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPS 231
CPN T S + C AP CPL ++ + + P C P P
Sbjct: 1798 QTKPCPQDGCPNATCSGELMFQPC-AP--CPLTCDDISGQVTCPPDWPCGSPGCW--CPE 1852
Query: 232 GRTVLDFNSDSNERVTFKHQSYKAHHHSKSWAIEIGYQTRQVSCTRSDGQ-------NAM 284
G+ + S+ W + RQ C + A
Sbjct: 1853 GQVL----------------------GSEGWCV----WPRQCPCLVDGARYWPGQRIKAD 1886
Query: 285 LSLCL-QDSFPLTVQ---SCIMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHM 340
LC+ QD P + C + DC S WS W+ C C S S+ FRS S N +
Sbjct: 1887 CQLCICQDGRPRRCRLNPDCAV--DCGWSSWSPWAKCLGPCGSQSIQWSFRS-SNNPR-- 1941
Query: 341 AIGGGKECPELLEK---------EACIVEGELLQQCPRYSWRTSEWKECQVSLLLEQQDP 391
G G++C + K E C +G++ + R W + CQ L
Sbjct: 1942 PSGRGRQCRGIHRKARRCQTEPCEGCEHQGQVHRVGER--WHGGPCRVCQCLHNLTAHCS 1999
Query: 392 HWHVTGPVCGGGI---QTREVYCAQSVPAAAALRAKEVSRPVEKALCVGPAPLPSQLCNI 448
+ G G + T E C ++P ++ V+ AP PS
Sbjct: 2000 PYCPLGSCPQGWVLVEGTGESCCHCALPGE--------NQTVQPMATPAAAPAPSPQIRF 2051
Query: 449 PCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRH 485
P +T + S + C+ P G G H
Sbjct: 2052 PLATYILPPS--------GDPCYSPLGLAGLAEGSLH 2080
Score = 36.2 bits (82), Expect = 0.26
Identities = 30/89 (33%), Positives = 38/89 (42%), Gaps = 13/89 (14%)
Query: 136 PTEQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPNLT-ESRA 194
P EQ C P + PW CS+ CG Q R+R L CP +S+A
Sbjct: 1689 PEEQGCGAWGP-------WSPWGPCSRTCGPWGQGRSRRCSPLGLLVLQNCPGPEHQSQA 1741
Query: 195 CDAPISCPLGEEEYTFSLKVGPWSKCRLP 223
C +CP+ E T+S PWS C P
Sbjct: 1742 C-FTAACPVDGEWSTWS----PWSVCSEP 1765
Score = 34.7 bits (78), Expect = 0.75
Identities = 62/248 (25%), Positives = 76/248 (30%), Gaps = 58/248 (23%)
Query: 1169 NAPCGQGVRT----RLLSCV--CSDGKPVSMDQCEQ-HNLEKPQRMSIPCLVECVVNCQL 1221
+APC +G +L V C DG D C L P R +PC N
Sbjct: 1607 HAPCARGPHCVSPEQLCDGVRQCPDGSDEGPDACGGLPALGGPNRTGLPCPEYTCPNGTC 1666
Query: 1222 SGWTAWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPTELTQEKTCPVTPCYSWVLGNWS 1281
G+ + CG G++ P P E C +W G WS
Sbjct: 1667 IGFQLVCDGQPDCGRPGQVG--------------PSPEE---------QGCGAW--GPWS 1701
Query: 1282 ACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSILKQLC-SVPCPG 1340
CG Q RS C G + C Q Q C + CP
Sbjct: 1702 PWGPCSRTCGPWGQGRSRRCS--------PLGLLVLQNCPGPEHQS----QACFTAACPV 1749
Query: 1341 DCHLTEWSEWSTCELTCIDGRSFETVGRQSRS-----RTFI-----IQSFENQDSCPQQV 1390
D + WS WS C C R T RQ S RT + S CPQ
Sbjct: 1750 DGEWSTWSPWSVCSEPC---RGTMTRQRQCHSPQNGGRTCAALPGGLHSTRQTKPCPQDG 1806
Query: 1391 LETRPCTG 1398
C+G
Sbjct: 1807 CPNATCSG 1814
Score = 33.5 bits (75), Expect = 1.7
Identities = 37/143 (25%), Positives = 49/143 (34%), Gaps = 40/143 (27%)
Query: 1331 KQLCSVP--CPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRS------RTFIIQSFEN 1382
++LC P CP C + W WS C++ C G F R++ + R Q N
Sbjct: 4603 QRLCPDPGACPDSCQWSLWGPWSPCQVPCSGG--FRLRWREAEALCGGGCREPWAQESCN 4660
Query: 1383 QDSCP----QQVLETRPCTGGKCYHYTWKASLWNNNERTVWCQRSDGVNVTGGCSPQARP 1438
CP Q + T C +C H A LW+ V C +
Sbjct: 4661 GGPCPECEAQDTVFTLDC-ANQCPHSC--ADLWDR----VQCLQG--------------- 4698
Query: 1439 AAIRQCIPACRKPFSYCTQGGVC 1461
C P CR P Q G C
Sbjct: 4699 ----PCRPGCRCPPGQLVQDGRC 4717
Score = 31.2 bits (69), Expect = 8.3
Identities = 51/199 (25%), Positives = 68/199 (34%), Gaps = 47/199 (23%)
Query: 16 GPWGRCTGDCGPGGVQSRAVWCFHV--------DGWTSHLSNCGESNRPPKERSCFRVCD 67
GPWG C+ CGP G+ SR+ C + + HL G + P C C
Sbjct: 4314 GPWGPCSRSCGP-GLASRSGSCPCLMAKADPTCNSTFLHLDTQGCYSGP-----CPEECV 4367
Query: 68 WHSDLFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQ--HRMVRCIQKLNRTVVAN 125
W S W S W C R V+ R A G + R +++N
Sbjct: 4368 WSS----W--SSWTRC----SCRVLVQQRYRHQGPASRGARAGAPCTRLDGHFRPCLISN 4417
Query: 126 EICEHFALQPPTE-QACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGL 184
C + PP E AC P C+ C L H+ + PP G
Sbjct: 4418 --CSEDSCTPPFEFHACGSP---------------CAGLCATHLSHQLCQDL-PPCQPGC 4459
Query: 185 QCPN--LTESRACDAPISC 201
CP L ++ C P C
Sbjct: 4460 YCPKGLLEQAGGCIPPEEC 4478
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 112 bits (279), Expect = 4e-24
Identities = 107/365 (29%), Positives = 145/365 (39%), Gaps = 49/365 (13%)
Query: 922 QADSKECGEGLRFRAVACSD----KNGRPVDPSFCSSSGYIQEKCVI-PCPFDCKLSDWS 976
+A S CG+G++ R+ C+ G+P C S C PCP D S+WS
Sbjct: 4539 RACSVTCGKGIQKRSRLCNQPLPANGGKP-----CQGSDLEMRNCQNKPCPVDGSWSEWS 4593
Query: 977 SWGSCSSSCGIGVRIRSKWLKEKPY-NGGRPCPKLDLKNQAQVHEAVPCYSECNQYSWVV 1035
W C+ SCG G + R++ +GGRPC + + + PC +W
Sbjct: 4594 LWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAV--EIIMCNIRPCPVHGAWSAW-- 4649
Query: 1036 EHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQSCSLMC 1095
+ W +C S CG GTQ+R C N GG+ Q ++ E C
Sbjct: 4650 QPWGTC-------SESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERN-----C 4697
Query: 1096 PNECVMSEWGLWSKCPQSCDPHTMQRRTRHLLRP--SLNSRTCAEDSQVQPCLLNENCFQ 1153
P + W WS C SC QR TR P R C E S VQ N +
Sbjct: 4698 PIHGKWATWASWSACSVSCGGGARQR-TRGCSDPVPQYGGRKC-EGSDVQSDFCNSDPCP 4755
Query: 1154 FQYNLTEWS---TCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHNLEKPQRMSIP 1210
N + WS TC + C G R +C D P S P
Sbjct: 4756 THGNWSPWSGWGTCSRT----CNGGQMRRYRTC---DNPPPSNGG---RACGGPDSQIQR 4805
Query: 1211 CLVE-CVVNCQLSGWTAWTECSQTCGHGGRMSRTRFI--IMPTQGEGRPCPTELTQEKTC 1267
C + C V+ W +W++CS +CG GG +R R +P +G GRPCP + TQ C
Sbjct: 4806 CNTDMCPVDGSWGSWHSWSQCSASCG-GGEKTRKRLCDHPVPVKG-GRPCPGDTTQVTRC 4863
Query: 1268 PVTPC 1272
V C
Sbjct: 4864 NVQAC 4868
Score = 106 bits (265), Expect = 2e-22
Identities = 102/360 (28%), Positives = 141/360 (39%), Gaps = 69/360 (19%)
Query: 843 FTAWSKFTPCSTNCEATKSRRRQLTGK---SRKKEKCQDSDLYPL-VETELCPCDEFISQ 898
F+ WS + CS C +R +L + + + CQ SDL + + CP D
Sbjct: 4532 FSQWSAWRACSVTCGKGIQKRSRLCNQPLPANGGKPCQGSDLEMRNCQNKPCPVD----- 4586
Query: 899 PYGNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSDKN----GRPVDPSFCSS 954
G+WS+ L E ++ CG G + R C++ + GRP C
Sbjct: 4587 --GSWSEWSLWE------------ECTRSCGRGNQTRTRTCNNPSVQHGGRP-----CEG 4627
Query: 955 SGYIQEKCVI-PCPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKE-KPYNGGRPCPKLDL 1012
+ C I PCP S W WG+CS SCG G + R++ P GG C
Sbjct: 4628 NAVEIIMCNIRPCPVHGAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCD--GA 4685
Query: 1013 KNQAQVHEAVPCYSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADG--- 1069
+ Q QV C +W WS+C S+ CGGG + R C +
Sbjct: 4686 ETQMQVCNERNCPIHGKWATWA--SWSAC-------SVSCGGGARQRTRGCSDPVPQYGG 4736
Query: 1070 ---EGGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEWGLWSKCPQSCDPHTMQR-RTRH 1125
EG V S+ CN D CP S W W C ++C+ M+R RT
Sbjct: 4737 RKCEGSDVQSDFCNSDP-----------CPTHGNWSPWSGWGTCSRTCNGGQMRRYRTCD 4785
Query: 1126 LLRPSLNSRTC-AEDSQVQPCLLNENCFQFQY-NLTEWSTCQLSENAPCGQGVRTRLLSC 1183
PS R C DSQ+Q C + + + WS C +A CG G +TR C
Sbjct: 4786 NPPPSNGGRACGGPDSQIQRCNTDMCPVDGSWGSWHSWSQC----SASCGGGEKTRKRLC 4841
Score = 100 bits (249), Expect = 1e-20
Identities = 103/378 (27%), Positives = 148/378 (39%), Gaps = 62/378 (16%)
Query: 783 SVWQGITGSSEACGKGLQTRAVSCISDDNRSAEMMECLKQTNGMPLLVQEC-TVPCREDC 841
S W S CGKG+Q R+ C + K G L ++ C PC D
Sbjct: 4533 SQWSAWRACSVTCGKGIQKRSRLCNQPLPANGG-----KPCQGSDLEMRNCQNKPCPVDG 4587
Query: 842 TFTAWSKFTPCSTNC-EATKSRRRQLTGKS-RKKEKCQDSDLYPLVETELCPCDEFISQP 899
+++ WS + C+ +C ++R R S + + + + ++ + PC
Sbjct: 4588 SWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPC-----PV 4642
Query: 900 YGNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSDKNGRPV-DPSFCSSSGYI 958
+G WS P G S+ CG+G + RA C+ N P S+C +
Sbjct: 4643 HGAWS-AWQPWG-----------TCSESCGKGTQTRARLCN--NPPPAFGGSYCDGAETQ 4688
Query: 959 QEKC-VIPCPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEK-PYNGGRPCPKLDLKNQA 1016
+ C CP K + W+SW +CS SCG G R R++ + P GGR C D+ Q+
Sbjct: 4689 MQVCNERNCPIHGKWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGSDV--QS 4746
Query: 1017 QVHEAVPCYSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAV-- 1074
+ PC + N W W +C S C GG R C N GG
Sbjct: 4747 DFCNSDPCPTHGNWSPW--SGWGTC-------SRTCNGGQMRRYRTCDNPPPSNGGRACG 4797
Query: 1075 --DSNL--CNQDEIPPETQSCSLMCPNECVMSEWGLWSKCPQSC--DPHTMQRRTRHLLR 1128
DS + CN D MCP + W WS+C SC T +R H +
Sbjct: 4798 GPDSQIQRCNTD-----------MCPVDGSWGSWHSWSQCSASCGGGEKTRKRLCDHPV- 4845
Query: 1129 PSLNSRTCAED-SQVQPC 1145
P R C D +QV C
Sbjct: 4846 PVKGGRPCPGDTTQVTRC 4863
Score = 95.1 bits (235), Expect = 5e-19
Identities = 96/346 (27%), Positives = 131/346 (37%), Gaps = 73/346 (21%)
Query: 1038 WSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQSC-SLMCP 1096
W +C S+ CG G Q R C GG C ++ E ++C + CP
Sbjct: 4538 WRAC-------SVTCGKGIQKRSRLCNQPLPANGGKP----CQGSDL--EMRNCQNKPCP 4584
Query: 1097 NECVMSEWGLWSKCPQSCDPHTMQRRTRHLLRPSLN--SRTCAEDS------QVQPCLLN 1148
+ SEW LW +C +SC Q RTR PS+ R C ++ ++PC ++
Sbjct: 4585 VDGSWSEWSLWEECTRSCGRGN-QTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPCPVH 4643
Query: 1149 ENCFQFQYNLTEWSTCQLSENAPCGQGVRTRLLSC----------VCSDGKPVSMDQCEQ 1198
+Q W TC S CG+G +TR C C DG M C +
Sbjct: 4644 GAWSAWQ----PWGTCSES----CGKGTQTRARLCNNPPPAFGGSYC-DGAETQMQVCNE 4694
Query: 1199 HNLEKPQRMSIPCLVECVVNCQLSGWTAWTECSQTCGHGGRMSRTRFIIMPT-QGEGRPC 1257
N C ++ + + W +W+ CS +CG GG RTR P Q GR C
Sbjct: 4695 RN--------------CPIHGKWATWASWSACSVSCG-GGARQRTRGCSDPVPQYGGRKC 4739
Query: 1258 PTELTQEKTCPVTPCYSWVLGNWSACKLEGG---DCGEGVQIRSLSCMVHSGSISHAAGR 1314
Q C PC + GNWS G C G R +C GR
Sbjct: 4740 EGSDVQSDFCNSDPCPTH--GNWSPWSGWGTCSRTCNGGQMRRYRTC---DNPPPSNGGR 4794
Query: 1315 VEDALCGEMPFQDSILKQLCSVPCPGDCHLTEWSEWSTCELTCIDG 1360
CG DS +++ + CP D W WS C +C G
Sbjct: 4795 A----CGG---PDSQIQRCNTDMCPVDGSWGSWHSWSQCSASCGGG 4833
Score = 93.6 bits (231), Expect = 1e-18
Identities = 97/361 (26%), Positives = 133/361 (36%), Gaps = 64/361 (17%)
Query: 662 TCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPETVRPCF-LPCKKDCIVTAFSEWTPCPR 720
TCG GIQ R C + K C S +R C PC D + +S W C R
Sbjct: 4544 TCGKGIQKRSRLC-NQPLPANGGKPCQGSDLE--MRNCQNKPCPVDGSWSEWSLWEECTR 4600
Query: 721 MCQAGNATVKQSRYRIIIQEAANGGQECPDTLYEERECEDVSLCPVYRWKPQKWSPCILV 780
C GN T ++ +Q +GG+ C E C ++ CPV+ WS
Sbjct: 4601 SCGRGNQTRTRTCNNPSVQ---HGGRPCEGNAVEIIMC-NIRPCPVHG----AWS----- 4647
Query: 781 PESVWQGITGSSEACGKGLQTRAVSCISD---------DNRSAEMMECLKQTNGMPLLVQ 831
WQ SE+CGKG QTRA C + D +M C ++
Sbjct: 4648 ---AWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERN-------- 4696
Query: 832 ECTVPCREDCTFTAWSKFTPCSTNCEATKSRRRQLTGKSRKK---EKCQDSDLYPLVETE 888
C + W+ ++ CS +C +R + + KC+ SD V+++
Sbjct: 4697 -----CPIHGKWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGSD----VQSD 4747
Query: 889 LCPCDEFISQPYGNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSDKNGRPVD 948
C D +GNWS P G S+ C G R C +
Sbjct: 4748 FCNSDP--CPTHGNWS----------PWSGW--GTCSRTCNGGQMRRYRTCDNPPPSNGG 4793
Query: 949 PSFCSSSGYIQEKCVIPCPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEK-PYNGGRPC 1007
+ IQ CP D W SW CS+SCG G + R + P GGRPC
Sbjct: 4794 RACGGPDSQIQRCNTDMCPVDGSWGSWHSWSQCSASCGGGEKTRKRLCDHPVPVKGGRPC 4853
Query: 1008 P 1008
P
Sbjct: 4854 P 4854
Score = 79.0 bits (193), Expect = 3e-14
Identities = 72/274 (26%), Positives = 115/274 (41%), Gaps = 43/274 (15%)
Query: 1102 SEWGLWSKCPQSCDPHTMQR-RTRHLLRPSLNSRTC-AEDSQVQPCLLNENCFQFQYNLT 1159
S+W W C +C +R R + P+ + C D +++ C N+ C + +
Sbjct: 4533 SQWSAWRACSVTCGKGIQKRSRLCNQPLPANGGKPCQGSDLEMRNCQ-NKPC-PVDGSWS 4590
Query: 1160 EWSTCQLSENAPCGQGVRTRLLSC----VCSDGKPVSMDQCEQHNLEKPQRMSIPCLVE- 1214
EWS + + CG+G +TR +C V G+P CE + +E I C +
Sbjct: 4591 EWSLWEECTRS-CGRGNQTRTRTCNNPSVQHGGRP-----CEGNAVE-----IIMCNIRP 4639
Query: 1215 CVVNCQLSGWTAWTECSQTCGHGGRMSRTRFIIMPTQG------EGRPCPTELTQEKTCP 1268
C V+ S W W CS++CG G + +R R P +G ++ E+ CP
Sbjct: 4640 CPVHGAWSAWQPWGTCSESCGKGTQ-TRARLCNNPPPAFGGSYCDGAETQMQVCNERNCP 4698
Query: 1269 VTPCYSWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDS 1328
+ ++ +WSAC + CG G + R+ C S + GR +
Sbjct: 4699 IHGKWA-TWASWSACSVS---CGGGARQRTRGC---SDPVPQYGGRKCEG--------SD 4743
Query: 1329 ILKQLC-SVPCPGDCHLTEWSEWSTCELTCIDGR 1361
+ C S PCP + + WS W TC TC G+
Sbjct: 4744 VQSDFCNSDPCPTHGNWSPWSGWGTCSRTCNGGQ 4777
Score = 76.3 bits (186), Expect = 2e-13
Identities = 73/275 (26%), Positives = 103/275 (37%), Gaps = 62/275 (22%)
Query: 1161 WSTCQLSENAPCGQGVRTRLLSC----VCSDGKPVSMDQCEQHNLE-KPQRMSIPCLVEC 1215
W C ++ CG+G++ R C + GKP E N + KP C
Sbjct: 4538 WRACSVT----CGKGIQKRSRLCNQPLPANGGKPCQGSDLEMRNCQNKP----------C 4583
Query: 1216 VVNCQLSGWTAWTECSQTCGHGGRMSRTRFIIMPT-QGEGRPCPTELTQEKTCPVTPCYS 1274
V+ S W+ W EC+++CG G + +RTR P+ Q GRPC + C + PC
Sbjct: 4584 PVDGSWSEWSLWEECTRSCGRGNQ-TRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPCP- 4641
Query: 1275 WVLGNWSACKLEGG---DCGEGVQIRSLSCM----VHSGSISHAAGRVEDALCGEMPFQD 1327
V G WSA + G CG+G Q R+ C GS A + +C E
Sbjct: 4642 -VHGAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGA-ETQMQVCNERN--- 4696
Query: 1328 SILKQLCSVPCPGDCHLTEWSEWSTCELTCIDGRSFET---------VGRQSRSRTFIIQ 1378
CP W+ WS C ++C G T G + + +
Sbjct: 4697 ----------CPIHGKWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGSDVQS 4746
Query: 1379 SFENQDSCPQQ---------VLETRPCTGGKCYHY 1404
F N D CP +R C GG+ Y
Sbjct: 4747 DFCNSDPCPTHGNWSPWSGWGTCSRTCNGGQMRRY 4781
Score = 72.0 bits (175), Expect = 4e-12
Identities = 114/424 (26%), Positives = 147/424 (34%), Gaps = 132/424 (31%)
Query: 309 SQWSSWSPCSKTCRSGSLLPGFRSRSRNVKH-MAIGGGKECP------ELLEKEACIVEG 361
SQWS+W CS TC G + RSR + GGK C + + C V+G
Sbjct: 4533 SQWSAWRACSVTCGK-----GIQKRSRLCNQPLPANGGKPCQGSDLEMRNCQNKPCPVDG 4587
Query: 362 ELLQQCPRYSW-RTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAA 420
SW S W+EC S CG G QTR C
Sbjct: 4588 ---------SWSEWSLWEECTRS----------------CGRGNQTRTRTCNNP------ 4616
Query: 421 LRAKEVSRPVEKALCVGPAPLPSQLCNI-PCSTDCIVSSWSAWGLCIHENCHDPQGKKGF 479
+ RP C G A + +CNI PC S+W WG C E+C KG
Sbjct: 4617 -SVQHGGRP-----CEGNA-VEIIMCNIRPCPVHGAWSAWQPWGTC-SESC-----GKGT 4663
Query: 480 RTRQRHVLMESTGPAGHCPHLVESVPCEDPMCYRWLASEGICFPDHGK------------ 527
+TR R L + PA + C+ + +E C P HGK
Sbjct: 4664 QTRAR--LCNNPPPAFGGSY------CDGAETQMQVCNERNC-PIHGKWATWASWSACSV 4714
Query: 528 -CGLGHRILKAVCQND---------RGEDVSGSLCPVPPPPERKSCEIPCRMDCVLSEWT 577
CG G R C + G DV C P P + S W+
Sbjct: 4715 SCGGGARQRTRGCSDPVPQYGGRKCEGSDVQSDFCNSDPCPTHGN----------WSPWS 4764
Query: 578 EWSSCSQSCSNKNSDGKQTRSRTI-LALAGEGGKPC--PPSQALQEHRLCNDHSC-MQLH 633
W +CS++C+ G+ R RT GG+ C P SQ + CN C +
Sbjct: 4765 GWGTCSRTCNG----GQMRRYRTCDNPPPSNGGRACGGPDSQI----QRCNTDMCPVDGS 4816
Query: 634 WET-SPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKR-CPDST 691
W + W CS A+CG G +TR+ C H V R CP T
Sbjct: 4817 WGSWHSWSQCS-----------------ASCGGGEKTRKRLC--DHPVPVKGGRPCPGDT 4857
Query: 692 RPET 695
T
Sbjct: 4858 TQVT 4861
Score = 65.9 bits (159), Expect = 3e-10
Identities = 111/484 (22%), Positives = 156/484 (32%), Gaps = 154/484 (31%)
Query: 152 SEFLPWSNCSKGCGKKLQHRTRAVIAP-PLFGGLQCPNL-TESRACDAPISCPLGEEEYT 209
S++ W CS CGK +Q R+R P P GG C E R C CP+
Sbjct: 4533 SQWSAWRACSVTCGKGIQKRSRLCNQPLPANGGKPCQGSDLEMRNCQNK-PCPVDGSWSE 4591
Query: 210 FSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDSNERVTFKHQSYKAHHHSKSWAIEIGYQ 269
+SL W +C GR N+ T + H +
Sbjct: 4592 WSL----WEEC-------TRSCGR--------GNQTRTRTCNNPSVQHGGRP-------- 4624
Query: 270 TRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCETSQWSSWSPCSKTCRSGSLLPG 329
+G + +C ++ C P S W W CS++C G+
Sbjct: 4625 --------CEGNAVEIIMC-------NIRPC--PVHGAWSAWQPWGTCSESCGKGTQT-- 4665
Query: 330 FRSRSRNVKHMAIGGGKECPELLEKEACIVEGELLQQCPRY-SWRT-SEWKECQVSLLLE 387
R+R N A GG + + C + CP + W T + W C VS
Sbjct: 4666 -RARLCNNPPPAFGGSYCDGAETQMQVCNE-----RNCPIHGKWATWASWSACSVS---- 4715
Query: 388 QQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKALCVGPAPLPSQLCN 447
CGGG + R C+ VP + C G + + S CN
Sbjct: 4716 ------------CGGGARQRTRGCSDPVPQYGGRK------------CEG-SDVQSDFCN 4750
Query: 448 I-PCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVESVPC 506
PC T S WS WG C C+ Q ++ +RT C
Sbjct: 4751 SDPCPTHGNWSPWSGWGTC-SRTCNGGQMRR-YRT------------------------C 4784
Query: 507 EDPMCYRWLASEGICFPDHGKCGLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSCEIP 566
++P P +G G C P ++
Sbjct: 4785 DNPP------------PSNG----------------------GRACGGPDSQIQRCNTDM 4810
Query: 567 CRMDCVLSEWTEWSSCSQSCSNKNSDGKQTRSRTI-LALAGEGGKPCPPSQALQEHRLCN 625
C +D W WS CS SC G++TR R + +GG+PC P Q R CN
Sbjct: 4811 CPVDGSWGSWHSWSQCSASCGG----GEKTRKRLCDHPVPVKGGRPC-PGDTTQVTR-CN 4864
Query: 626 DHSC 629
+C
Sbjct: 4865 VQAC 4868
Score = 64.7 bits (156), Expect = 7e-10
Identities = 83/361 (22%), Positives = 122/361 (33%), Gaps = 73/361 (20%)
Query: 18 WGRCTGDCGPGGVQSRAVWCFH---------VDGWTSHLSNCGESNRPPKERSCFRVCDW 68
W C+ CG G +Q R+ C G + NC N+P C
Sbjct: 4538 WRACSVTCGKG-IQKRSRLCNQPLPANGGKPCQGSDLEMRNC--QNKP---------CPV 4585
Query: 69 HSDLFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEIC 128
+W + W C + + RT + QHG C
Sbjct: 4586 DGSWSEWSL--WEECTRSCGRGNQTRTRTCNNPSVQHG------------------GRPC 4625
Query: 129 EHFALQPPTEQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAV-IAPPLFGGLQCP 187
E A++ + PCP S + PW CS+ CGK Q R R PP FGG C
Sbjct: 4626 EGNAVE--IIMCNIRPCPVHGAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCD 4683
Query: 188 NL-TESRACDAPISCPLGEEEYTFSLKVGPWSKCR-----------------LPHLKEIN 229
T+ + C+ +CP+ + T++ WS C +P
Sbjct: 4684 GAETQMQVCNER-NCPIHGKWATWA----SWSACSVSCGGGARQRTRGCSDPVPQYGGRK 4738
Query: 230 PSGRTVLDFNSDSNERVTFKHQSYKAHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCL 289
G V +S+ T + S + + S G R +C N +
Sbjct: 4739 CEGSDVQSDFCNSDPCPTHGNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGG 4798
Query: 290 QDSFPLTVQSCIMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKH-MAIGGGKEC 348
DS + + P D W SWS CS +C G ++R R H + + GG+ C
Sbjct: 4799 PDSQIQRCNTDMCPVDGSWGSWHSWSQCSASCGGGE-----KTRKRLCDHPVPVKGGRPC 4853
Query: 349 P 349
P
Sbjct: 4854 P 4854
Score = 42.0 bits (97), Expect = 0.005
Identities = 40/133 (30%), Positives = 55/133 (41%), Gaps = 23/133 (17%)
Query: 1280 WSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSIL--KQLCSVP 1337
WSA + CG+G+Q RS C + + G+ P Q S L + + P
Sbjct: 4535 WSAWRACSVTCGKGIQKRSRLC---NQPLPANGGK---------PCQGSDLEMRNCQNKP 4582
Query: 1338 CPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQSFENQD-SCPQQVLETRPC 1396
CP D +EWS W C +C GR G Q+R+RT S ++ C +E C
Sbjct: 4583 CPVDGSWSEWSLWEECTRSC--GR-----GNQTRTRTCNNPSVQHGGRPCEGNAVEIIMC 4635
Query: 1397 TGGKC-YHYTWKA 1408
C H W A
Sbjct: 4636 NIRPCPVHGAWSA 4648
Score = 40.4 bits (93), Expect = 0.014
Identities = 48/195 (24%), Positives = 63/195 (32%), Gaps = 55/195 (28%)
Query: 17 PWGRCTGDCGPGGVQSRAVWC---------FHVDGWTSHLSNCGESNRPPKERSCFRVCD 67
PWG C+ CG G Q+RA C + DG + + C E N C
Sbjct: 4651 PWGTCSESCGKG-TQTRARLCNNPPPAFGGSYCDGAETQMQVCNERN-----------CP 4698
Query: 68 WHSDLFQWEVSDWHHCVLVPYARGEVKPRTAECV--TAQHGLQHRMVRCIQKLNRTVVAN 125
H W + W C + G + RT C Q+G + K + V +
Sbjct: 4699 IHGKWATW--ASWSACSVS--CGGGARQRTRGCSDPVPQYGGR--------KCEGSDVQS 4746
Query: 126 EICEHFALQPPTEQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQ 185
+ C PCP S + W CS+ C R R PP G
Sbjct: 4747 DFCNSD------------PCPTHGNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNG-- 4792
Query: 186 CPNLTESRACDAPIS 200
RAC P S
Sbjct: 4793 ------GRACGGPDS 4801
>gi|147904700 semaphorin 5A [Homo sapiens]
Length = 1074
Score = 103 bits (257), Expect = 1e-21
Identities = 99/375 (26%), Positives = 149/375 (39%), Gaps = 69/375 (18%)
Query: 975 WSSWGSCSSSCGIGVRIRSKWLKEK-PYNGGRPCPKLDLKNQAQVHEAVPCYSECNQYSW 1033
W+SW CS++CGIG ++R + P +GGR C + + + +E + C W
Sbjct: 601 WTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQN-REERYCNEHLLCPPHMFWTGW 659
Query: 1034 VVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQSCSL 1093
W C + +CGGG Q+R+ C N D G V+ CN +
Sbjct: 660 --GPWERC-------TAQCGGGIQARRRICENGPDCAGCNVEYQSCNTNP---------- 700
Query: 1094 MCPNECVMSEWGLWSKCPQSCDPHTMQRRTRHLL-------------RPSLNSRTCAEDS 1140
CP + W W+ S + ++R R+ R + R C+ D
Sbjct: 701 -CPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDG 759
Query: 1141 QVQPCLLNENCFQF----QYNL----------TEWSTCQLSENAPCGQGVRTRLLSCVCS 1186
C + F +Y+ T WS C + C +G+R R C
Sbjct: 760 -TSGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQC----SRDCSRGIRNRKRVCNNP 814
Query: 1187 DGKPVSMDQCEQHNLEKPQRMSIPCLVECVVNCQLSGWTAWTECSQTCGHGGRMSRTRFI 1246
+ K M C +LE + +PC V+ V +C W+ WT+CS TCG GG RTR
Sbjct: 815 EPKYGGMP-CLGPSLEYQECNILPCPVDGVWSC----WSPWTKCSATCG-GGHYMRTRSC 868
Query: 1247 IMPTQGEGRP-CPTELTQEKTCPVTPC-YSW-VLGNWSACKLEGGDCGEGVQIRSLSCMV 1303
P G C T+E C PC SW +WS C+ GVQ+R+ C++
Sbjct: 869 SNPAPAYGGDICLGLHTEEALCNTQPCPESWSEWSDWSECE------ASGVQVRARQCIL 922
Query: 1304 HSGSISHAAGRVEDA 1318
S +G ++
Sbjct: 923 LFPMGSQCSGNTTES 937
Score = 93.2 bits (230), Expect = 2e-18
Identities = 141/559 (25%), Positives = 189/559 (33%), Gaps = 137/559 (24%)
Query: 907 ILPEGRREPHRGLRVQADSKECGEGLRFRAVACSDKN------------------GRPVD 948
+ PE RREP R L++ GLR V K G V
Sbjct: 450 LFPERRREPIRSLQILHSQSVLFVGLREHVVKIPLKRCQFYRTRSTCIGAQDPYCGWDVV 509
Query: 949 PSFCSS-----SGYIQEKCVIPCP-----FDCKLSDWSSWGSCSSSCGIGV-----RIRS 993
C+S S E+ + CP D WS W C+ + G V R RS
Sbjct: 510 MKKCTSLEESLSMTQWEQSISACPTRNLTVDGHFGVWSPWTPCTHTDGSAVGSCLCRTRS 569
Query: 994 KWLKEKPYNGGRPC--PKLDLKNQAQVHEAVPCYSECNQYSWVVEHWSSCKINNELRSLR 1051
P GG C P +++ N C W WS C S
Sbjct: 570 -CDSPAPQCGGWQCEGPGMEIAN---------CSRNGGWTPWT--SWSPC-------STT 610
Query: 1052 CGGGTQSRKIRCVNTADGEGGAV------DSNLCNQDEIPPETQSCSLMCPNECVMSEWG 1105
CG G Q R+ C N GG V + CN+ L+CP + WG
Sbjct: 611 CGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEH----------LLCPPHMFWTGWG 660
Query: 1106 LWSKCPQSCDPHTMQRRTRHLLRPSLNSRTCAE-DSQVQPCLLNENCFQFQYNL--TEWS 1162
W +C C RR R N CA + + Q C N C + + T W+
Sbjct: 661 PWERCTAQCGGGIQARR-----RICENGPDCAGCNVEYQSCNTNP-CPELKKTTPWTPWT 714
Query: 1163 TCQLSENA---------PCGQGV---------RTRLLSCVC-SDGKPVSMDQCEQHNLEK 1203
+S+N C + R R+ C SDG + +
Sbjct: 715 PVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDGTSGCSTDGLSGDFLR 774
Query: 1204 PQRMSIPCLVECVVNCQLSGWTAWTECSQTCGHGGRMSRTRFIIMP-TQGEGRPCPTELT 1262
R S VN S WT+W++CS+ C G R +R R P + G PC
Sbjct: 775 AGRYSAH-----TVNGAWSAWTSWSQCSRDCSRGIR-NRKRVCNNPEPKYGGMPCLGPSL 828
Query: 1263 QEKTCPVTPC-YSWVLGNWSACKLEGGDCGEGVQIRSLSCM----VHSGSISHAAGRVED 1317
+ + C + PC V WS CG G +R+ SC + G I E+
Sbjct: 829 EYQECNILPCPVDGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGL-HTEE 887
Query: 1318 ALCGEMPFQDSILKQLCSVPCPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFII 1377
ALC P +S +EWS+WS CE + G Q R+R I+
Sbjct: 888 ALCNTQPCPES---------------WSEWSDWSECEAS----------GVQVRARQCIL 922
Query: 1378 QSFENQDSCPQQVLETRPC 1396
F C E+RPC
Sbjct: 923 -LFPMGSQCSGNTTESRPC 940
Score = 83.6 bits (205), Expect = 1e-15
Identities = 88/361 (24%), Positives = 140/361 (38%), Gaps = 43/361 (11%)
Query: 703 CKKDCIVTAFSEWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQECPDTLYEERECEDVS 762
C ++ T ++ W+PC C G ++S +GG+ C EER C +
Sbjct: 592 CSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSN---PTPRHGGRVCVGQNREERYCNEHL 648
Query: 763 LCPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCISDDNRSAEMMECLKQ 822
LCP + + W P W+ T CG G+Q R C + + +
Sbjct: 649 LCPPHMFWTG-WGP--------WERCTAQ---CGGGIQARRRICENGPDCA--------- 687
Query: 823 TNGMPLLVQEC-TVPCREDCTFTAWSKFTPCSTNCEATKSRRR-QLTGKSRKKEKCQDSD 880
G + Q C T PC E T W+ +TP + + +R + T K+R +
Sbjct: 688 --GCNVEYQSCNTNPCPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEV 745
Query: 881 LYPLVETELCPCDEFISQPYGNWSDCILPEGRREPHRGLRVQAD-------SKECGEGLR 933
+E C D S L GR H + S++C G+R
Sbjct: 746 GRQRIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIR 805
Query: 934 FRAVACSDKNGRPVDPSFCSSSGYIQEKCVIPCPFDCKLSDWSSWGSCSSSCGIGVRIRS 993
R C++ + S QE ++PCP D S WS W CS++CG G +R+
Sbjct: 806 NRKRVCNNPEPKYGGMPCLGPSLEYQECNILPCPVDGVWSCWSPWTKCSATCGGGHYMRT 865
Query: 994 KWLKE-KPYNGGRPCPKLDLKNQAQVHEAVPCYSECNQYSWVVEHWSSCKINN-ELRSLR 1051
+ P GG C L L + + PC +++S WS C+ + ++R+ +
Sbjct: 866 RSCSNPAPAYGGDIC--LGLHTEEALCNTQPCPESWSEWS----DWSECEASGVQVRARQ 919
Query: 1052 C 1052
C
Sbjct: 920 C 920
Score = 78.6 bits (192), Expect = 5e-14
Identities = 108/460 (23%), Positives = 155/460 (33%), Gaps = 81/460 (17%)
Query: 712 FSEWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQECPDTLYEERECEDVSLCPVYRWKP 771
+S WTPC + + GG +C E C W P
Sbjct: 546 WSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGPGMEIANCSRNG-----GWTP 600
Query: 772 -QKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCISDDNRSAEMMECLKQTNGMPLLV 830
WSPC S CG G Q R SC + R + C+ Q
Sbjct: 601 WTSWSPC--------------STTCGIGFQVRQRSCSNPTPRHGGRV-CVGQNREERYCN 645
Query: 831 QECTVPCREDCTFTAWSKFTPCSTNCEATKSRRRQLTGKSRKKEKCQDSDLYPLVETELC 890
+ C +T W + C+ C RR++ C VE + C
Sbjct: 646 EHLL--CPPHMFWTGWGPWERCTAQCGGGIQARRRICENGPDCAGCN-------VEYQSC 696
Query: 891 ---PCDEFI-SQPYGNWSDCILPEGRREPHRGLRVQADSKECGEGL------RFRAVACS 940
PC E + P+ W+ + + + R ++ L R CS
Sbjct: 697 NTNPCPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCS 756
Query: 941 DKNGRPVDPSFCSSSG----YIQEKCVIPCPFDCKLSDWSSWGSCSSSCGIGVRIRSKWL 996
S CS+ G +++ + S W+SW CS C G+R R +
Sbjct: 757 SDG-----TSGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVC 811
Query: 997 KE-KPYNGGRPC--PKLDLKNQAQVHEAVPCYSECNQYSWVVEHWSSCKINNELRSLRCG 1053
+P GG PC P L+ Y ECN V+ SC S CG
Sbjct: 812 NNPEPKYGGMPCLGPSLE-------------YQECNILPCPVDGVWSCWSPWTKCSATCG 858
Query: 1054 GGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQSCSLM-CPNECVMSEWGLWSKCPQ 1112
GG R C N A GG + L ++ + C+ CP SEW WS+C
Sbjct: 859 GGHYMRTRSCSNPAPAYGGDICLGLHTEEAL------CNTQPCPES--WSEWSDWSECEA 910
Query: 1113 SCDPHTMQRRTRH--LLRPSLNSRTCAEDSQVQPCLLNEN 1150
S +Q R R LL P + S+ ++ +PC+ + N
Sbjct: 911 S----GVQVRARQCILLFP-MGSQCSGNTTESRPCVFDSN 945
Score = 72.4 bits (176), Expect = 3e-12
Identities = 99/397 (24%), Positives = 143/397 (36%), Gaps = 69/397 (17%)
Query: 539 CQNDRGEDVSGSLCPV----PPPPERKS--CEIP------CRMDCVLSEWTEWSSCSQSC 586
C + G V LC P P+ CE P C + + WT WS CS +C
Sbjct: 552 CTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGPGMEIANCSRNGGWTPWTSWSPCSTTC 611
Query: 587 SNKNSDGKQTRSRTIL-ALAGEGGKPCPPSQALQEHRLCNDHSCMQLHWETSPWGPCSED 645
G Q R R+ GG+ C +E R CN+H H + WGP
Sbjct: 612 ----GIGFQVRQRSCSNPTPRHGGRVCVGQN--REERYCNEHLLCPPHMFWTGWGPWERC 665
Query: 646 TLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPET-VRPCFL-PC 703
T A CG GIQ RR C + PD + C PC
Sbjct: 666 T--------------AQCGGGIQARRRIC----------ENGPDCAGCNVEYQSCNTNPC 701
Query: 704 KKDCIVTAFSEWTPCPRMCQAGNATVKQSRY----RIIIQEAANGGQECPDTLYEERE-- 757
+ T ++ WTP + G ++ RY R+ G++ + Y +
Sbjct: 702 PELKKTTPWTPWTPV-NISDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDGT 760
Query: 758 --CEDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCISDDNRSAE 815
C L + + + + S W + S C +G++ R C + + +
Sbjct: 761 SGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGG 820
Query: 816 MMECLKQTNGMPLLVQECTV-PCREDCTFTAWSKFTPCSTNCEATKSRRRQLTGKSRKKE 874
M CL G L QEC + PC D ++ WS +T CS C R T
Sbjct: 821 -MPCL----GPSLEYQECNILPCPVDGVWSCWSPWTKCSATCGGGHYMR---TRSCSNPA 872
Query: 875 KCQDSDLYPLVETE--LC---PCDEFISQPYGNWSDC 906
D+ + TE LC PC E S+ + +WS+C
Sbjct: 873 PAYGGDICLGLHTEEALCNTQPCPESWSE-WSDWSEC 908
Score = 63.2 bits (152), Expect = 2e-09
Identities = 104/420 (24%), Positives = 135/420 (32%), Gaps = 115/420 (27%)
Query: 275 CTRSDGQNAMLSLCLQDSFPLTVQSC---------IMPKDCETS----QWSSWSPCSKTC 321
CT +DG LC S C + +C + W+SWSPCS TC
Sbjct: 552 CTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGPGMEIANCSRNGGWTPWTSWSPCSTTC 611
Query: 322 RSGSLLPGFRSRSRNVKHMAIG-GGKECPELLEKEACIVEGELLQQCPRYSWRTS--EWK 378
G F+ R R+ + GG+ C +E E L CP + + T W+
Sbjct: 612 GIG-----FQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLL---CPPHMFWTGWGPWE 663
Query: 379 ECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKALCVGP 438
C CGGGIQ R C A
Sbjct: 664 RCTAQ----------------CGGGIQARRRICENGPDCAGC------------------ 689
Query: 439 APLPSQLCNI-PCSTDCIVSSWSAWG-LCIHEN---------------CHDPQGKKGFRT 481
+ Q CN PC + W+ W + I +N DP + R
Sbjct: 690 -NVEYQSCNTNPCPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQ 748
Query: 482 RQRHVLMESTGPAG---------------HCPHLVESVPCEDPMCYRWLA--SEGICFPD 524
R S G +G + H V W A S C D
Sbjct: 749 RIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSAHTVNGA---------WSAWTSWSQCSRD 799
Query: 525 HGKCGLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSCEI-PCRMDCVLSEWTEWSSCS 583
C G R K VC N E G + + P E + C I PC +D V S W+ W+ CS
Sbjct: 800 ---CSRGIRNRKRVCNNP--EPKYGGMPCLGPSLEYQECNILPCPVDGVWSCWSPWTKCS 854
Query: 584 QSCSNKNSDGKQTRSRTILALA-GEGGKPCPPSQALQEHRLCNDHSCMQLHWETSPWGPC 642
+C G R+R+ A GG C E LCN C + E S W C
Sbjct: 855 ATCGG----GHYMRTRSCSNPAPAYGGDICLGLHT--EEALCNTQPCPESWSEWSDWSEC 908
Score = 55.5 bits (132), Expect = 4e-07
Identities = 87/369 (23%), Positives = 123/369 (33%), Gaps = 100/369 (27%)
Query: 145 CPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAP-PLFGGLQCPNLT-ESRACDAPISCP 202
C R+ + + WS CS CG Q R R+ P P GG C E R C+ + CP
Sbjct: 592 CSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLLCP 651
Query: 203 LGEEEYTFSLKVGPWSKCR----------------------------------LPHLKEI 228
+ F GPW +C P LK+
Sbjct: 652 ----PHMFWTGWGPWERCTAQCGGGIQARRRICENGPDCAGCNVEYQSCNTNPCPELKKT 707
Query: 229 NP----SGRTVLDFNSDSNERVTFKHQSYKAHHHSKSWAIEIGYQTRQVSCTRSDGQNAM 284
P + + D +R + ++ A + +E+G Q ++ SDG +
Sbjct: 708 TPWTPWTPVNISDNGGHYEQRFRYTCKARLADPN----LLEVGRQRIEMRYCSSDGTSGC 763
Query: 285 LSLCLQDSFPLTVQSCIMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIG- 343
+ L F + + S W+SWS CS+ C G R+R R +
Sbjct: 764 STDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSR-----GIRNRKRVCNNPEPKY 818
Query: 344 GGKEC--PELLEKEA----CIVEGELLQQCPRYSWRTSEWKECQVSLLLEQQDPHWHVTG 397
GG C P L +E C V+G + C W S W +C +
Sbjct: 819 GGMPCLGPSLEYQECNILPCPVDG--VWSC----W--SPWTKCSAT-------------- 856
Query: 398 PVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKALCVGPAPLPSQLCNI-PCSTDCIV 456
CGGG R C+ PA +C+G LCN PC
Sbjct: 857 --CGGGHYMRTRSCSNPAPAYGG------------DICLG-LHTEEALCNTQPCPESW-- 899
Query: 457 SSWSAWGLC 465
S WS W C
Sbjct: 900 SEWSDWSEC 908
Score = 51.2 bits (121), Expect = 8e-06
Identities = 83/304 (27%), Positives = 109/304 (35%), Gaps = 65/304 (21%)
Query: 1162 STCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHNLEKPQRMSIPCLVECVVNCQL 1221
STC +++ CG V ++ S + +SM Q EQ P R V+
Sbjct: 494 STCIGAQDPYCGWDV---VMKKCTSLEESLSMTQWEQSISACPTR-------NLTVDGHF 543
Query: 1222 SGWTAWTECSQTCGH--GGRMSRTRFIIMPT-QGEGRPCPTELTQEKTCPVTPCYS-WVL 1277
W+ WT C+ T G G + RTR P Q G C + C ++ W
Sbjct: 544 GVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGPGMEIANCSRNGGWTPWT- 602
Query: 1278 GNWSACKLEGGDCGEGVQIRSLSCMV----HSGSISHAAGRVEDALCGEMPFQDSILKQL 1333
+WS C CG G Q+R SC H G + R E+ C E
Sbjct: 603 -SWSPCSTT---CGIGFQVRQRSCSNPTPRHGGRVCVGQNR-EERYCNE----------- 646
Query: 1334 CSVPCPGDCHLTEWSEWSTCELTCIDG----RSFETVGRQSRSRTFIIQSFENQDSCPQQ 1389
+ CP T W W C C G R G QS N + CP +
Sbjct: 647 -HLLCPPHMFWTGWGPWERCTAQCGGGIQARRRICENGPDCAGCNVEYQSC-NTNPCP-E 703
Query: 1390 VLETRPCT----------GG---KCYHYTWKASLWNNNERTVWCQR-------SDGVNVT 1429
+ +T P T GG + + YT KA L + N V QR SDG T
Sbjct: 704 LKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDG---T 760
Query: 1430 GGCS 1433
GCS
Sbjct: 761 SGCS 764
Score = 50.8 bits (120), Expect = 1e-05
Identities = 102/485 (21%), Positives = 164/485 (33%), Gaps = 91/485 (18%)
Query: 840 DCTFTAWSKFTPCS-TNCEATKSRRRQLTGKSRKKEKCQDSDLY-PLVETELCPCDEFIS 897
D F WS +TPC+ T+ A S + +C P +E C + +
Sbjct: 540 DGHFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGPGMEIANCSRNGGWT 599
Query: 898 QPYGNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSD---KNGRPVDPSFCSS 954
P+ +WS C S CG G + R +CS+ ++G V
Sbjct: 600 -PWTSWSPC------------------STTCGIGFQVRQRSCSNPTPRHGGRVCVGQNRE 640
Query: 955 SGYIQEKCVIPCPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKPYNGG---------- 1004
Y E + CP + W W C++ CG G++ R + + P G
Sbjct: 641 ERYCNEHLL--CPPHMFWTGWGPWERCTAQCGGGIQARRRICENGPDCAGCNVEYQSCNT 698
Query: 1005 RPCPKLDLKNQAQVHEAVPCYSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCV 1064
PCP +LK P N + +CK +L G + C
Sbjct: 699 NPCP--ELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYC- 755
Query: 1065 NTADGEGGAVDSNLCNQDEIPPETQSCSLMCPNEC--VMSEWGLWSKCPQSCDPHTMQRR 1122
++DG G C+ D + + + S W WS+C + C R+
Sbjct: 756 -SSDGTSG------CSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRK 808
Query: 1123 T-----------RHLLRPSLNSRTCAEDSQVQPCLLNE--NCFQFQYNLTEWSTCQLSEN 1169
L PSL + C + PC ++ +C+ + W+ C +
Sbjct: 809 RVCNNPEPKYGGMPCLGPSLEYQEC----NILPCPVDGVWSCW------SPWTKC----S 854
Query: 1170 APCGQGVRTRLLSCVCSDGKPVSMDQCEQHNLEKPQRMSIPCLVECVVNCQLSGWTAWTE 1229
A CG G R SC + D C + E+ + PC W+ W++
Sbjct: 855 ATCGGGHYMRTRSC-SNPAPAYGGDICLGLHTEEALCNTQPC---------PESWSEWSD 904
Query: 1230 CSQTCGHGGRMSRTR--FIIMPTQGEGRPCPTELTQEKTCPVTPCYSWVLGNWSACKLEG 1287
S+ C G R R ++ P G C T+ + C + + + +E
Sbjct: 905 WSE-CEASGVQVRARQCILLFPM---GSQCSGNTTESRPCVFDSNFIPEVSVARSSSVEE 960
Query: 1288 GDCGE 1292
CGE
Sbjct: 961 KRCGE 965
Score = 47.4 bits (111), Expect = 1e-04
Identities = 64/273 (23%), Positives = 94/273 (34%), Gaps = 45/273 (16%)
Query: 145 CPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQ----------CPNLTESRA 194
CP + + PW C+ CG +Q R R P G CP L ++
Sbjct: 650 CPPHMFWTGWGPWERCTAQCGGGIQARRRICENGPDCAGCNVEYQSCNTNPCPELKKTTP 709
Query: 195 CDAPISCPLGEEEYTFSLKVGPWSKCRL--PHLKEINPSGRTVLDFNSDSNERVTFKHQS 252
+ + + + K RL P+L E+ + +SD + S
Sbjct: 710 WTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDGTSGCSTDGLS 769
Query: 253 --------YKAHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSL----------CLQDSFP 294
Y AH + +W+ + C+R + CL S
Sbjct: 770 GDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPS-- 827
Query: 295 LTVQSCIM---PKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIG-GGKECPE 350
L Q C + P D S WS W+ CS TC G + R+R+ + A GG C
Sbjct: 828 LEYQECNILPCPVDGVWSCWSPWTKCSATCGGGHYM-----RTRSCSNPAPAYGGDICLG 882
Query: 351 LLEKEACIVEGELLQQCPRYSWRTSEWKECQVS 383
L +EA Q CP S+W EC+ S
Sbjct: 883 LHTEEALCNT----QPCPESWSEWSDWSECEAS 911
Score = 46.6 bits (109), Expect = 2e-04
Identities = 32/85 (37%), Positives = 42/85 (49%), Gaps = 10/85 (11%)
Query: 139 QAC-LIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAP-PLFGGLQCPNL-TESRAC 195
Q C ++PCP D V S + PW+ CS CG RTR+ P P +GG C L TE C
Sbjct: 831 QECNILPCPVDGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALC 890
Query: 196 DAPISCPLGEEEYTFSLKVGPWSKC 220
+ CP E++ WS+C
Sbjct: 891 NTQ-PCPESWSEWS------DWSEC 908
Score = 43.5 bits (101), Expect = 0.002
Identities = 122/557 (21%), Positives = 181/557 (32%), Gaps = 172/557 (30%)
Query: 268 YQTRQVSCTRSD---GQNAMLSLC--LQDSFPLT-----VQSCI---MPKDCETSQWSSW 314
Y+TR D G + ++ C L++S +T + +C + D WS W
Sbjct: 490 YRTRSTCIGAQDPYCGWDVVMKKCTSLEESLSMTQWEQSISACPTRNLTVDGHFGVWSPW 549
Query: 315 SPCSKTCRS--GSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEGELLQQCPRYSW 372
+PC+ T S GS L R+RS + GG + C G + C R
Sbjct: 550 TPCTHTDGSAVGSCL--CRTRSCDSPAPQCGGWQ----------CEGPGMEIANCSRNGG 597
Query: 373 RT--SEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPV 430
T + W C + CG G Q R+ C+ P
Sbjct: 598 WTPWTSWSPCSTT----------------CGIGFQVRQRSCSNPTPRHGG---------- 631
Query: 431 EKALCVGPAPLPSQLCN--IPCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQR---- 484
+CVG + CN + C + W W C Q G + R+R
Sbjct: 632 --RVCVG-QNREERYCNEHLLCPPHMFWTGWGPWERC------TAQCGGGIQARRRICEN 682
Query: 485 -------HVLMESTGPAGHCPHLVESVPCED-------------PMCYRWLASEGICFPD 524
+V +S CP L ++ P +R+ + P+
Sbjct: 683 GPDCAGCNVEYQSCN-TNPCPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPN 741
Query: 525 HGKCGLGHRILKAVCQND-----RGEDVSGSLCPVPPPPERKSCEIPCRMDCVLSEWTEW 579
+ G RI C +D + +SG R ++ S WT W
Sbjct: 742 LLEVG-RQRIEMRYCSSDGTSGCSTDGLSGDFL-------RAGRYSAHTVNGAWSAWTSW 793
Query: 580 SSCSQSCSNKNSDGKQTRSRTILALAGE-GGKPC-PPSQALQEHRLCNDHSC-MQLHWET 636
S CS+ CS G + R R + GG PC PS QE CN C + W
Sbjct: 794 SQCSRDCSR----GIRNRKRVCNNPEPKYGGMPCLGPSLEYQE---CNILPCPVDGVWSC 846
Query: 637 -SPWGPCSEDTLVTALNATIGWNGEATCGVG--IQTRRV----------FCVKSHVGQVM 683
SPW CS ATCG G ++TR C+ H + +
Sbjct: 847 WSPWTKCS-----------------ATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEAL 889
Query: 684 --TKRCPDSTRPETVRPCFLPCKKDCIVTAFSEWTPCPRMCQAGNATVKQSRYRIIIQEA 741
T+ CP+S +SEW+ C+A V+ + ++
Sbjct: 890 CNTQPCPES---------------------WSEWSDWSE-CEASGVQVRARQCILLFPM- 926
Query: 742 ANGGQECPDTLYEEREC 758
G +C E R C
Sbjct: 927 ---GSQCSGNTTESRPC 940
Score = 32.3 bits (72), Expect = 3.7
Identities = 13/22 (59%), Positives = 15/22 (68%), Gaps = 1/22 (4%)
Query: 16 GPWGRCTGDCGPGGVQSRAVWC 37
GPW RCT CG GG+Q+R C
Sbjct: 660 GPWERCTAQCG-GGIQARRRIC 680
>gi|223718260 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 102 bits (254), Expect = 3e-21
Identities = 110/386 (28%), Positives = 158/386 (40%), Gaps = 70/386 (18%)
Query: 976 SSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKL--DLKNQAQVHEAVPCYSECNQYSW 1033
SS CS++C GV S + Y+G L VHE C Q W
Sbjct: 571 SSHEPCSATCTTGVM--SAYAMCVRYDGVEVDDSYCDALTRPEPVHEF--CAGRECQPRW 626
Query: 1034 VVEHWSSCKINNELRSLRCGGGTQSRKIRCVNT-ADGEGGAVDSNLCNQDEI--PPETQS 1090
WS C S CG G Q R +RC + G +V S+LC E P E ++
Sbjct: 627 ETSSWSEC-------SRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKT 679
Query: 1091 C-SLMCPNECVMSEWGLWSKCPQSCDPHTMQRRTRHLLRPSLNSRTCAEDSQVQPCLLNE 1149
C + C + MSEW S+C C ++ R +R S + + C D +P + +
Sbjct: 680 CRNPACGPQWEMSEW---SECTAKCGERSVVTRD---IRCSEDEKLC--DPNTRP-VGEK 730
Query: 1150 NCF----QFQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHNLEKPQ 1205
NC Q+ +++W C S CGQG R + C SDG+ V QC+ KP
Sbjct: 731 NCTGPPCDRQWTVSDWGPCSGS----CGQGRTIRHVYCKTSDGRVVPESQCQMET--KPL 784
Query: 1206 RMSIPCLVECVVNCQLSGWTA--WTECSQTCGHGGRMSRTRFIIMPTQGEGRP------- 1256
+ PC + NC + W A W C+ TCG G + R ++ G+P
Sbjct: 785 AIH-PCGDK---NCP-AHWLAQDWERCNTTCGRG---VKKRLVLCMELANGKPQTRSGPE 836
Query: 1257 --CPTELTQEKTCPVTPCYSWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGR 1314
+ +E TC PC+ W WS C CG GV++R + C + G+
Sbjct: 837 CGLAKKPPEESTCFERPCFKWYTSPWSECT---KTCGVGVRMRDVKC--YQGT------- 884
Query: 1315 VEDALCGEMPFQDSILKQLCSV-PCP 1339
D + G P + +Q C + PCP
Sbjct: 885 --DIVRGCDPLVKPVGRQACDLQPCP 908
Score = 85.5 bits (210), Expect = 4e-16
Identities = 106/429 (24%), Positives = 151/429 (35%), Gaps = 107/429 (24%)
Query: 301 IMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVE 360
+ P D + SS PCS TC +G + + + V++ + + L + + E
Sbjct: 560 VSPADMYRWKLSSHEPCSATCTTGVM----SAYAMCVRYDGVEVDDSYCDALTRPEPVHE 615
Query: 361 GELLQQC-PRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYC-------A 412
++C PR W TS W EC CG G Q R V C
Sbjct: 616 FCAGRECQPR--WETSSWSEC----------------SRTCGEGYQFRVVRCWKMLSPGF 657
Query: 413 QSVPAAAALRAKEVSRPVEKALCVGPAPLPSQLCNIPCSTDCIVSSWSAWGLCIHENCHD 472
S + A E RP E+ C PA C +S WS C
Sbjct: 658 DSSVYSDLCEAAEAVRPEERKTCRNPA----------CGPQWEMSEWS--------ECTA 699
Query: 473 PQGKKGFRTR------QRHVLMESTGPAGHCPHLVESVPCEDPMCYR-WLASEGICFPDH 525
G++ TR + +T P G C P C R W S+ P
Sbjct: 700 KCGERSVVTRDIRCSEDEKLCDPNTRPVG-------EKNCTGPPCDRQWTVSD--WGPCS 750
Query: 526 GKCGLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSCEI-PCRMDCVLSEW--TEWSSC 582
G CG G I C+ G V S C + E K I PC + W +W C
Sbjct: 751 GSCGQGRTIRHVYCKTSDGRVVPESQCQM----ETKPLAIHPCGDKNCPAHWLAQDWERC 806
Query: 583 SQSCSNKNSDGKQTRSRTILALAGEGGKP-------CPPSQALQEHRLCNDHSCMQLHWE 635
+ +C G+ + R +L + GKP C ++ E C + C + W
Sbjct: 807 NTTC------GRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFK--WY 858
Query: 636 TSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPET 695
TSPW C++ TCGVG++ R V C + G + + C +P
Sbjct: 859 TSPWSECTK-----------------TCGVGVRMRDVKC---YQGTDIVRGCDPLVKPVG 898
Query: 696 VRPCFL-PC 703
+ C L PC
Sbjct: 899 RQACDLQPC 907
Score = 81.3 bits (199), Expect = 7e-15
Identities = 85/366 (23%), Positives = 124/366 (33%), Gaps = 64/366 (17%)
Query: 759 EDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCISDDNRSAEMME 818
+ VS +YRWK PC S C G+ + C+ D +
Sbjct: 558 QGVSPADMYRWKLSSHEPC--------------SATCTTGVMSAYAMCVRYDGVEVDDSY 603
Query: 819 CLKQTNGMPLLVQECTVPCREDCTFTAWSKFTPCSTNCEATKSRRRQLTGK--------S 870
C T P+ C+ ++WS+ CS C R K S
Sbjct: 604 CDALTRPEPVHEFCAGRECQPRWETSSWSE---CSRTCGEGYQFRVVRCWKMLSPGFDSS 660
Query: 871 RKKEKCQDSDLYPLVETELCPCDEFISQ-PYGNWSDCILPEGRREP-HRGLRVQADSKEC 928
+ C+ ++ E + C Q WS+C G R R +R D K C
Sbjct: 661 VYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLC 720
Query: 929 GEGLRFRAVACSDKNGRPVDPSFCSSSGYIQEKCVIPCPFDCKLSDWSSWGSCSSSCGIG 988
D N RPV C+ PC +SDW G CS SCG G
Sbjct: 721 ------------DPNTRPVGEKNCTGP---------PCDRQWTVSDW---GPCSGSCGQG 756
Query: 989 VRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHEAVPCYSECNQYSWVVEHWSSCKINNELR 1048
IR + K + GR P+ + + + PC + W+ + W C
Sbjct: 757 RTIRHVYCKT---SDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTT---- 809
Query: 1049 SLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEWGLWS 1108
CG G + R + C+ A+G+ C + PPE +C C WS
Sbjct: 810 ---CGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTC---FERPCFKWYTSPWS 863
Query: 1109 KCPQSC 1114
+C ++C
Sbjct: 864 ECTKTC 869
Score = 76.3 bits (186), Expect = 2e-13
Identities = 93/379 (24%), Positives = 132/379 (34%), Gaps = 94/379 (24%)
Query: 449 PCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVESVP--- 505
PCS C SA+ +C+ R V ++ + +C L P
Sbjct: 575 PCSATCTTGVMSAYAMCV---------------RYDGVEVDDS----YCDALTRPEPVHE 615
Query: 506 -CEDPMCY-RWLASE-GICFPDHGKCGLGHRILKAVCQNDRGEDVS--GSLCPVPP---P 557
C C RW S C G+ G R+++ G D S LC P
Sbjct: 616 FCAGRECQPRWETSSWSECSRTCGE-GYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRP 674
Query: 558 PERKSCEIP-CRMDCVLSEWTEWSSCSQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQ 616
ERK+C P C +SEW+E C+ C ++ + R E K C P+
Sbjct: 675 EERKTCRNPACGPQWEMSEWSE---CTAKCGERSVVTRDIR-------CSEDEKLCDPNT 724
Query: 617 ALQEHRLCNDHSCMQLHWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVK 676
+ C C + W S WGPCS +CG G R V+C
Sbjct: 725 RPVGEKNCTGPPCDR-QWTVSDWGPCS-----------------GSCGQGRTIRHVYCKT 766
Query: 677 SHVGQVMTKRCPDSTRPETVRPCFLPCKKDCIVTAFS-EWTPCPRMCQAGNATVKQSRYR 735
S V +C T+P + PC K+C + +W C C G +
Sbjct: 767 SDGRVVPESQCQMETKPLAIHPC---GDKNCPAHWLAQDWERCNTTCGRG-----VKKRL 818
Query: 736 IIIQEAANG------GQEC--PDTLYEERECEDVSLCPVYRWKPQKWSPCILVPESVWQG 787
++ E ANG G EC EE C + P ++W WS C
Sbjct: 819 VLCMELANGKPQTRSGPECGLAKKPPEESTCFE---RPCFKWYTSPWSEC---------- 865
Query: 788 ITGSSEACGKGLQTRAVSC 806
++ CG G++ R V C
Sbjct: 866 ----TKTCGVGVRMRDVKC 880
Score = 73.9 bits (180), Expect = 1e-12
Identities = 110/454 (24%), Positives = 159/454 (35%), Gaps = 119/454 (26%)
Query: 21 CTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFRVCDWHSDLFQWEVSDW 80
C+ C G V S C DG S C RP C +WE S W
Sbjct: 576 CSATCTTG-VMSAYAMCVRYDGVEVDDSYCDALTRP---EPVHEFCAGRECQPRWETSSW 631
Query: 81 HHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNR---TVVANEICEHF-ALQPP 136
C T G Q R+VRC + L+ + V +++CE A++P
Sbjct: 632 SECSR----------------TCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPE 675
Query: 137 TEQACLIP-CPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPNLTESRAC 195
+ C P C +SE WS C+ CG+ R+V+ ++C + + C
Sbjct: 676 ERKTCRNPACGPQWEMSE---WSECTAKCGE------RSVVT----RDIRCSE--DEKLC 720
Query: 196 DAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGR--TVLDFNSDSNERVTFKHQSY 253
D P + P+GE+ T GP P R TV D+ S
Sbjct: 721 D-PNTRPVGEKNCT-----GP-------------PCDRQWTVSDWGPCSG---------- 751
Query: 254 KAHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCETSQW-- 311
+ G R V C SDG+ S C ++ PL + C K+C + W
Sbjct: 752 ---------SCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPC-GDKNC-PAHWLA 800
Query: 312 SSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIV-----EGELLQQ 366
W C+ TC G + R V M + GK P+ C + E +
Sbjct: 801 QDWERCNTTCGRG-------VKKRLVLCMELANGK--PQTRSGPECGLAKKPPEESTCFE 851
Query: 367 CPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEV 426
P + W TS W EC CG G++ R+V C Q +
Sbjct: 852 RPCFKWYTSPWSECT----------------KTCGVGVRMRDVKCYQGTDIVRG--CDPL 893
Query: 427 SRPVEKALC-VGPAPL--PSQLCNIPCSTDCIVS 457
+PV + C + P P P C T+C ++
Sbjct: 894 VKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALA 927
Score = 65.5 bits (158), Expect = 4e-10
Identities = 98/424 (23%), Positives = 151/424 (35%), Gaps = 111/424 (26%)
Query: 634 WETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRP 693
W+ S PCS ATC G+ + CV+ +V C TRP
Sbjct: 568 WKLSSHEPCS-----------------ATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRP 610
Query: 694 ETVRPCFLPCKKDCIVTAFSEWTPCPRMCQAG------------NATVKQSRYRIIIQEA 741
E V F ++ S W+ C R C G + S Y + + A
Sbjct: 611 EPVHE-FCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAA 669
Query: 742 ANGGQECPDTLYEERECEDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACG-KGLQ 800
E E + C + + P +W+ +WS C + CG + +
Sbjct: 670 EAVRPE------ERKTCRNPACGP--QWEMSEWSEC--------------TAKCGERSVV 707
Query: 801 TRAVSCISDDNRSAEMMECLKQTNGMPLLVQECT-VPCREDCTFTAWSKFTPCSTNCEAT 859
TR + C D+ L N P+ + CT PC T + W PCS +C
Sbjct: 708 TRDIRCSEDEK--------LCDPNTRPVGEKNCTGPPCDRQWTVSDWG---PCSGSCGQG 756
Query: 860 KSRR----RQLTGKSRKKEKCQDSDLYPLVETELCPCDE------FISQPYGNWSDCILP 909
++ R + G+ + +CQ + PL + PC + +++Q +W C
Sbjct: 757 RTIRHVYCKTSDGRVVPESQCQ-METKPLA---IHPCGDKNCPAHWLAQ---DWERC--- 806
Query: 910 EGRREPHRGLRVQADSKECGEGLRFRAVACSD-KNGRPVDPSFCSSSGYIQEKCVIPCPF 968
+ CG G++ R V C + NG+P S G ++ F
Sbjct: 807 ---------------NTTCGRGVKKRLVLCMELANGKPQTRSG-PECGLAKKPPEESTCF 850
Query: 969 DCKLSDW--SSWGSCSSSCGIGVRIRSKWLKEKPYNGG---RPCPKLDLKNQAQVHEAVP 1023
+ W S W C+ +CG+GVR+R K Y G R C L Q + P
Sbjct: 851 ERPCFKWYTSPWSECTKTCGVGVRMRD----VKCYQGTDIVRGCDPLVKPVGRQACDLQP 906
Query: 1024 CYSE 1027
C +E
Sbjct: 907 CPTE 910
Score = 62.4 bits (150), Expect = 3e-09
Identities = 88/358 (24%), Positives = 124/358 (34%), Gaps = 89/358 (24%)
Query: 257 HHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCETS-QWSSWS 315
H S G + C R DG S C + P V ++C+ + SSWS
Sbjct: 573 HEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWS 632
Query: 316 PCSKTCRSG----------SLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEGELLQ 365
CS+TC G L PGF S + + E E++ C
Sbjct: 633 ECSRTCGEGYQFRVVRCWKMLSPGFDSS----VYSDLCEAAEAVRPEERKTC------RN 682
Query: 366 QCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCG-GGIQTREVYCAQSVPAAAALRAK 424
W SEW EC CG + TR++ C++
Sbjct: 683 PACGPQWEMSEWSECTAK----------------CGERSVVTRDIRCSEDEKL-----CD 721
Query: 425 EVSRPVEKALCVGPAPLPSQLCNIPCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQR 484
+RPV + C GP PC VS WG C G G R
Sbjct: 722 PNTRPVGEKNCTGP----------PCDRQWTVSD---WGPC--------SGSCGQGRTIR 760
Query: 485 HVLMESTG----PAGHCPHLVESV---PCEDPMC-YRWLASE-GICFPDHGKCGLGHRIL 535
HV +++ P C + + PC D C WLA + C + CG G +
Sbjct: 761 HVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERC---NTTCGRGVKKR 817
Query: 536 KAVCQ---NDRGEDVSGSLCPV-PPPPERKSC-EIPCRMDCVLSEW--TEWSSCSQSC 586
+C N + + SG C + PPE +C E PC +W + WS C+++C
Sbjct: 818 LVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC------FKWYTSPWSECTKTC 869
Score = 57.8 bits (138), Expect = 8e-08
Identities = 83/339 (24%), Positives = 128/339 (37%), Gaps = 64/339 (18%)
Query: 1154 FQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHNLEKPQRMSIPCLV 1213
+++ L+ C +A C GV + CV DG V C+ L +P+ + C
Sbjct: 566 YRWKLSSHEPC----SATCTTGVMSAYAMCVRYDGVEVDDSYCDA--LTRPEPVHEFCAG 619
Query: 1214 -ECVVNCQLSGWTAWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPTELTQ--------- 1263
EC + S +W+ECS+TCG G + R M + G ++L +
Sbjct: 620 RECQPRWETS---SWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEE 676
Query: 1264 EKTCPVTPCY-SWVLGNWSACKLEGGDCGE-GVQIRSLSCMVHSGSISHAAGRVEDALCG 1321
KTC C W + WS C + CGE V R + C ++ LC
Sbjct: 677 RKTCRNPACGPQWEMSEWSECTAK---CGERSVVTRDIRCSE------------DEKLCD 721
Query: 1322 EMPFQDSILKQLCSVPCPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQSFE 1381
P + ++ C+ P P D T S+W C +C GR+ V ++ + +S
Sbjct: 722 --PNTRPVGEKNCTGP-PCDRQWTV-SDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQC 777
Query: 1382 NQDSCPQQVLETRPCTGGKCYHYTWKASLWNN---------NERTVWC-QRSDGVNVTGG 1431
++ P L PC C + W A W +R V C + ++G T
Sbjct: 778 QMETKP---LAIHPCGDKNCPAH-WLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRS 833
Query: 1432 ---CS-----PQARPAAIRQCIPACRKPFSYCTQGGVCG 1462
C P+ R C P+S CT+ CG
Sbjct: 834 GPECGLAKKPPEESTCFERPCFKWYTSPWSECTK--TCG 870
Score = 55.5 bits (132), Expect = 4e-07
Identities = 52/192 (27%), Positives = 71/192 (36%), Gaps = 40/192 (20%)
Query: 18 WGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCF-RVCDWHSDLFQWE 76
WG C+G CG G R V+C DG S C +P C + C H W
Sbjct: 746 WGPCSGSCGQGRT-IRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAH-----WL 799
Query: 77 VSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICE-HFALQP 135
DW C T G++ R+V C++ N E A +P
Sbjct: 800 AQDWERCN----------------TTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKP 843
Query: 136 PTEQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPNLTE-SRA 194
P E C R C PWS C+K CG ++ R ++C T+ R
Sbjct: 844 PEESTCF---ERPCFKWYTSPWSECTKTCGVGVRMR-----------DVKCYQGTDIVRG 889
Query: 195 CDAPISCPLGEE 206
CD P+ P+G +
Sbjct: 890 CD-PLVKPVGRQ 900
Score = 51.6 bits (122), Expect = 6e-06
Identities = 44/153 (28%), Positives = 62/153 (40%), Gaps = 33/153 (21%)
Query: 1 MHNTADEVVLYHKLAGPWGRCTGDCGPGGVQSRAVWCFHVDG---WTSHLSNCGESNRPP 57
+H D+ H LA W RC CG GV+ R V C + T CG + +PP
Sbjct: 786 IHPCGDKNCPAHWLAQDWERCNTTCG-RGVKKRLVLCMELANGKPQTRSGPECGLAKKPP 844
Query: 58 KERSCF-RVCDWHSDLFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQ 116
+E +CF R C F+W S W C T G++ R V+C Q
Sbjct: 845 EESTCFERPC------FKWYTSPWSECT----------------KTCGVGVRMRDVKCYQ 882
Query: 117 KLNRTVVANEICEHFALQPPTEQAC-LIPCPRD 148
+ + + ++P QAC L PCP +
Sbjct: 883 GTDIVRGCDPL-----VKPVGRQACDLQPCPTE 910
Score = 44.7 bits (104), Expect = 7e-04
Identities = 41/156 (26%), Positives = 62/156 (39%), Gaps = 38/156 (24%)
Query: 18 WGRCTGDCGPGGVQSRAVWCFHV------DGWTSHLSNCGESNRPPKERSCFRVCDWHSD 71
W C+ CG G Q R V C+ + S L E+ RP + ++C
Sbjct: 631 WSECSRTCGEG-YQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGP-- 687
Query: 72 LFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHF 131
QWE+S+W C TA+C + + R +RC + ++C+
Sbjct: 688 --QWEMSEWSEC-------------TAKC--GERSVVTRDIRCSED-------EKLCDP- 722
Query: 132 ALQPPTEQACL-IPCPRDCVVSEFLPWSNCSKGCGK 166
+P E+ C PC R VS+ W CS CG+
Sbjct: 723 NTRPVGEKNCTGPPCDRQWTVSD---WGPCSGSCGQ 755
Score = 37.7 bits (86), Expect = 0.088
Identities = 48/210 (22%), Positives = 72/210 (34%), Gaps = 31/210 (14%)
Query: 1273 YSWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSILKQ 1332
Y W L + C C GV C+ + G V+D+ C + + + +
Sbjct: 566 YRWKLSSHEPCS---ATCTTGVMSAYAMCVRYDGV------EVDDSYCDALTRPEPVHEF 616
Query: 1333 LCSVPCPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQSFEN---QDSCPQ- 1388
C E S WS C TC +G F V R + F++ D C
Sbjct: 617 CAGRECQPRW---ETSSWSECSRTCGEGYQFRVV----RCWKMLSPGFDSSVYSDLCEAA 669
Query: 1389 ---QVLETRPCTGGKCYHYTWKASLWNN-----NERTVWCQRSDGVNVTGGCSPQARPAA 1440
+ E + C C W+ S W+ ER+V + C P RP
Sbjct: 670 EAVRPEERKTCRNPAC-GPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVG 728
Query: 1441 IRQCI-PACRKPFSYCTQGGVCG-CEKGYT 1468
+ C P C + ++ G G C +G T
Sbjct: 729 EKNCTGPPCDRQWTVSDWGPCSGSCGQGRT 758
Score = 33.1 bits (74), Expect = 2.2
Identities = 15/56 (26%), Positives = 28/56 (50%), Gaps = 3/56 (5%)
Query: 575 EWTEWSSCSQSC-SNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHRLCNDHSC 629
EWT+W++CS+SC S + + ++ G G + C + + ++LC C
Sbjct: 52 EWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTS--KRYQLCRVQEC 105
Score = 32.0 bits (71), Expect = 4.9
Identities = 19/54 (35%), Positives = 26/54 (48%), Gaps = 6/54 (11%)
Query: 1224 WTAWTECSQTCGHGGRMSRTRFIIMPTQ----GEG-RPCPTELTQEKTCPVTPC 1272
WT WT CS++CG GG S+ R + + G G R C + + C V C
Sbjct: 53 WTKWTACSRSCG-GGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQEC 105
>gi|41281450 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 102 bits (254), Expect = 3e-21
Identities = 110/386 (28%), Positives = 158/386 (40%), Gaps = 70/386 (18%)
Query: 976 SSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKL--DLKNQAQVHEAVPCYSECNQYSW 1033
SS CS++C GV S + Y+G L VHE C Q W
Sbjct: 571 SSHEPCSATCTTGVM--SAYAMCVRYDGVEVDDSYCDALTRPEPVHEF--CAGRECQPRW 626
Query: 1034 VVEHWSSCKINNELRSLRCGGGTQSRKIRCVNT-ADGEGGAVDSNLCNQDEI--PPETQS 1090
WS C S CG G Q R +RC + G +V S+LC E P E ++
Sbjct: 627 ETSSWSEC-------SRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKT 679
Query: 1091 C-SLMCPNECVMSEWGLWSKCPQSCDPHTMQRRTRHLLRPSLNSRTCAEDSQVQPCLLNE 1149
C + C + MSEW S+C C ++ R +R S + + C D +P + +
Sbjct: 680 CRNPACGPQWEMSEW---SECTAKCGERSVVTRD---IRCSEDEKLC--DPNTRP-VGEK 730
Query: 1150 NCF----QFQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHNLEKPQ 1205
NC Q+ +++W C S CGQG R + C SDG+ V QC+ KP
Sbjct: 731 NCTGPPCDRQWTVSDWGPCSGS----CGQGRTIRHVYCKTSDGRVVPESQCQMET--KPL 784
Query: 1206 RMSIPCLVECVVNCQLSGWTA--WTECSQTCGHGGRMSRTRFIIMPTQGEGRP------- 1256
+ PC + NC + W A W C+ TCG G + R ++ G+P
Sbjct: 785 AIH-PCGDK---NCP-AHWLAQDWERCNTTCGRG---VKKRLVLCMELANGKPQTRSGPE 836
Query: 1257 --CPTELTQEKTCPVTPCYSWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGR 1314
+ +E TC PC+ W WS C CG GV++R + C + G+
Sbjct: 837 CGLAKKPPEESTCFERPCFKWYTSPWSECT---KTCGVGVRMRDVKC--YQGT------- 884
Query: 1315 VEDALCGEMPFQDSILKQLCSV-PCP 1339
D + G P + +Q C + PCP
Sbjct: 885 --DIVRGCDPLVKPVGRQACDLQPCP 908
Score = 85.5 bits (210), Expect = 4e-16
Identities = 106/429 (24%), Positives = 151/429 (35%), Gaps = 107/429 (24%)
Query: 301 IMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVE 360
+ P D + SS PCS TC +G + + + V++ + + L + + E
Sbjct: 560 VSPADMYRWKLSSHEPCSATCTTGVM----SAYAMCVRYDGVEVDDSYCDALTRPEPVHE 615
Query: 361 GELLQQC-PRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYC-------A 412
++C PR W TS W EC CG G Q R V C
Sbjct: 616 FCAGRECQPR--WETSSWSEC----------------SRTCGEGYQFRVVRCWKMLSPGF 657
Query: 413 QSVPAAAALRAKEVSRPVEKALCVGPAPLPSQLCNIPCSTDCIVSSWSAWGLCIHENCHD 472
S + A E RP E+ C PA C +S WS C
Sbjct: 658 DSSVYSDLCEAAEAVRPEERKTCRNPA----------CGPQWEMSEWS--------ECTA 699
Query: 473 PQGKKGFRTR------QRHVLMESTGPAGHCPHLVESVPCEDPMCYR-WLASEGICFPDH 525
G++ TR + +T P G C P C R W S+ P
Sbjct: 700 KCGERSVVTRDIRCSEDEKLCDPNTRPVG-------EKNCTGPPCDRQWTVSD--WGPCS 750
Query: 526 GKCGLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSCEI-PCRMDCVLSEW--TEWSSC 582
G CG G I C+ G V S C + E K I PC + W +W C
Sbjct: 751 GSCGQGRTIRHVYCKTSDGRVVPESQCQM----ETKPLAIHPCGDKNCPAHWLAQDWERC 806
Query: 583 SQSCSNKNSDGKQTRSRTILALAGEGGKP-------CPPSQALQEHRLCNDHSCMQLHWE 635
+ +C G+ + R +L + GKP C ++ E C + C + W
Sbjct: 807 NTTC------GRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFK--WY 858
Query: 636 TSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPET 695
TSPW C++ TCGVG++ R V C + G + + C +P
Sbjct: 859 TSPWSECTK-----------------TCGVGVRMRDVKC---YQGTDIVRGCDPLVKPVG 898
Query: 696 VRPCFL-PC 703
+ C L PC
Sbjct: 899 RQACDLQPC 907
Score = 81.3 bits (199), Expect = 7e-15
Identities = 85/366 (23%), Positives = 124/366 (33%), Gaps = 64/366 (17%)
Query: 759 EDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCISDDNRSAEMME 818
+ VS +YRWK PC S C G+ + C+ D +
Sbjct: 558 QGVSPADMYRWKLSSHEPC--------------SATCTTGVMSAYAMCVRYDGVEVDDSY 603
Query: 819 CLKQTNGMPLLVQECTVPCREDCTFTAWSKFTPCSTNCEATKSRRRQLTGK--------S 870
C T P+ C+ ++WS+ CS C R K S
Sbjct: 604 CDALTRPEPVHEFCAGRECQPRWETSSWSE---CSRTCGEGYQFRVVRCWKMLSPGFDSS 660
Query: 871 RKKEKCQDSDLYPLVETELCPCDEFISQ-PYGNWSDCILPEGRREP-HRGLRVQADSKEC 928
+ C+ ++ E + C Q WS+C G R R +R D K C
Sbjct: 661 VYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLC 720
Query: 929 GEGLRFRAVACSDKNGRPVDPSFCSSSGYIQEKCVIPCPFDCKLSDWSSWGSCSSSCGIG 988
D N RPV C+ PC +SDW G CS SCG G
Sbjct: 721 ------------DPNTRPVGEKNCTGP---------PCDRQWTVSDW---GPCSGSCGQG 756
Query: 989 VRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHEAVPCYSECNQYSWVVEHWSSCKINNELR 1048
IR + K + GR P+ + + + PC + W+ + W C
Sbjct: 757 RTIRHVYCKT---SDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTT---- 809
Query: 1049 SLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEWGLWS 1108
CG G + R + C+ A+G+ C + PPE +C C WS
Sbjct: 810 ---CGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTC---FERPCFKWYTSPWS 863
Query: 1109 KCPQSC 1114
+C ++C
Sbjct: 864 ECTKTC 869
Score = 76.3 bits (186), Expect = 2e-13
Identities = 93/379 (24%), Positives = 132/379 (34%), Gaps = 94/379 (24%)
Query: 449 PCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVESVP--- 505
PCS C SA+ +C+ R V ++ + +C L P
Sbjct: 575 PCSATCTTGVMSAYAMCV---------------RYDGVEVDDS----YCDALTRPEPVHE 615
Query: 506 -CEDPMCY-RWLASE-GICFPDHGKCGLGHRILKAVCQNDRGEDVS--GSLCPVPP---P 557
C C RW S C G+ G R+++ G D S LC P
Sbjct: 616 FCAGRECQPRWETSSWSECSRTCGE-GYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRP 674
Query: 558 PERKSCEIP-CRMDCVLSEWTEWSSCSQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQ 616
ERK+C P C +SEW+E C+ C ++ + R E K C P+
Sbjct: 675 EERKTCRNPACGPQWEMSEWSE---CTAKCGERSVVTRDIR-------CSEDEKLCDPNT 724
Query: 617 ALQEHRLCNDHSCMQLHWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVK 676
+ C C + W S WGPCS +CG G R V+C
Sbjct: 725 RPVGEKNCTGPPCDR-QWTVSDWGPCS-----------------GSCGQGRTIRHVYCKT 766
Query: 677 SHVGQVMTKRCPDSTRPETVRPCFLPCKKDCIVTAFS-EWTPCPRMCQAGNATVKQSRYR 735
S V +C T+P + PC K+C + +W C C G +
Sbjct: 767 SDGRVVPESQCQMETKPLAIHPC---GDKNCPAHWLAQDWERCNTTCGRG-----VKKRL 818
Query: 736 IIIQEAANG------GQEC--PDTLYEERECEDVSLCPVYRWKPQKWSPCILVPESVWQG 787
++ E ANG G EC EE C + P ++W WS C
Sbjct: 819 VLCMELANGKPQTRSGPECGLAKKPPEESTCFE---RPCFKWYTSPWSEC---------- 865
Query: 788 ITGSSEACGKGLQTRAVSC 806
++ CG G++ R V C
Sbjct: 866 ----TKTCGVGVRMRDVKC 880
Score = 73.9 bits (180), Expect = 1e-12
Identities = 110/454 (24%), Positives = 159/454 (35%), Gaps = 119/454 (26%)
Query: 21 CTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFRVCDWHSDLFQWEVSDW 80
C+ C G V S C DG S C RP C +WE S W
Sbjct: 576 CSATCTTG-VMSAYAMCVRYDGVEVDDSYCDALTRP---EPVHEFCAGRECQPRWETSSW 631
Query: 81 HHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNR---TVVANEICEHF-ALQPP 136
C T G Q R+VRC + L+ + V +++CE A++P
Sbjct: 632 SECSR----------------TCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPE 675
Query: 137 TEQACLIP-CPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPNLTESRAC 195
+ C P C +SE WS C+ CG+ R+V+ ++C + + C
Sbjct: 676 ERKTCRNPACGPQWEMSE---WSECTAKCGE------RSVVT----RDIRCSE--DEKLC 720
Query: 196 DAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGR--TVLDFNSDSNERVTFKHQSY 253
D P + P+GE+ T GP P R TV D+ S
Sbjct: 721 D-PNTRPVGEKNCT-----GP-------------PCDRQWTVSDWGPCSG---------- 751
Query: 254 KAHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCETSQW-- 311
+ G R V C SDG+ S C ++ PL + C K+C + W
Sbjct: 752 ---------SCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPC-GDKNC-PAHWLA 800
Query: 312 SSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIV-----EGELLQQ 366
W C+ TC G + R V M + GK P+ C + E +
Sbjct: 801 QDWERCNTTCGRG-------VKKRLVLCMELANGK--PQTRSGPECGLAKKPPEESTCFE 851
Query: 367 CPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEV 426
P + W TS W EC CG G++ R+V C Q +
Sbjct: 852 RPCFKWYTSPWSECT----------------KTCGVGVRMRDVKCYQGTDIVRG--CDPL 893
Query: 427 SRPVEKALC-VGPAPL--PSQLCNIPCSTDCIVS 457
+PV + C + P P P C T+C ++
Sbjct: 894 VKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALA 927
Score = 65.5 bits (158), Expect = 4e-10
Identities = 98/424 (23%), Positives = 151/424 (35%), Gaps = 111/424 (26%)
Query: 634 WETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRP 693
W+ S PCS ATC G+ + CV+ +V C TRP
Sbjct: 568 WKLSSHEPCS-----------------ATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRP 610
Query: 694 ETVRPCFLPCKKDCIVTAFSEWTPCPRMCQAG------------NATVKQSRYRIIIQEA 741
E V F ++ S W+ C R C G + S Y + + A
Sbjct: 611 EPVHE-FCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAA 669
Query: 742 ANGGQECPDTLYEERECEDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACG-KGLQ 800
E E + C + + P +W+ +WS C + CG + +
Sbjct: 670 EAVRPE------ERKTCRNPACGP--QWEMSEWSEC--------------TAKCGERSVV 707
Query: 801 TRAVSCISDDNRSAEMMECLKQTNGMPLLVQECT-VPCREDCTFTAWSKFTPCSTNCEAT 859
TR + C D+ L N P+ + CT PC T + W PCS +C
Sbjct: 708 TRDIRCSEDEK--------LCDPNTRPVGEKNCTGPPCDRQWTVSDWG---PCSGSCGQG 756
Query: 860 KSRR----RQLTGKSRKKEKCQDSDLYPLVETELCPCDE------FISQPYGNWSDCILP 909
++ R + G+ + +CQ + PL + PC + +++Q +W C
Sbjct: 757 RTIRHVYCKTSDGRVVPESQCQ-METKPLA---IHPCGDKNCPAHWLAQ---DWERC--- 806
Query: 910 EGRREPHRGLRVQADSKECGEGLRFRAVACSD-KNGRPVDPSFCSSSGYIQEKCVIPCPF 968
+ CG G++ R V C + NG+P S G ++ F
Sbjct: 807 ---------------NTTCGRGVKKRLVLCMELANGKPQTRSG-PECGLAKKPPEESTCF 850
Query: 969 DCKLSDW--SSWGSCSSSCGIGVRIRSKWLKEKPYNGG---RPCPKLDLKNQAQVHEAVP 1023
+ W S W C+ +CG+GVR+R K Y G R C L Q + P
Sbjct: 851 ERPCFKWYTSPWSECTKTCGVGVRMRD----VKCYQGTDIVRGCDPLVKPVGRQACDLQP 906
Query: 1024 CYSE 1027
C +E
Sbjct: 907 CPTE 910
Score = 62.4 bits (150), Expect = 3e-09
Identities = 88/358 (24%), Positives = 124/358 (34%), Gaps = 89/358 (24%)
Query: 257 HHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCETS-QWSSWS 315
H S G + C R DG S C + P V ++C+ + SSWS
Sbjct: 573 HEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWS 632
Query: 316 PCSKTCRSG----------SLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEGELLQ 365
CS+TC G L PGF S + + E E++ C
Sbjct: 633 ECSRTCGEGYQFRVVRCWKMLSPGFDSS----VYSDLCEAAEAVRPEERKTC------RN 682
Query: 366 QCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCG-GGIQTREVYCAQSVPAAAALRAK 424
W SEW EC CG + TR++ C++
Sbjct: 683 PACGPQWEMSEWSECTAK----------------CGERSVVTRDIRCSEDEKL-----CD 721
Query: 425 EVSRPVEKALCVGPAPLPSQLCNIPCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQR 484
+RPV + C GP PC VS WG C G G R
Sbjct: 722 PNTRPVGEKNCTGP----------PCDRQWTVSD---WGPC--------SGSCGQGRTIR 760
Query: 485 HVLMESTG----PAGHCPHLVESV---PCEDPMC-YRWLASE-GICFPDHGKCGLGHRIL 535
HV +++ P C + + PC D C WLA + C + CG G +
Sbjct: 761 HVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERC---NTTCGRGVKKR 817
Query: 536 KAVCQ---NDRGEDVSGSLCPV-PPPPERKSC-EIPCRMDCVLSEW--TEWSSCSQSC 586
+C N + + SG C + PPE +C E PC +W + WS C+++C
Sbjct: 818 LVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC------FKWYTSPWSECTKTC 869
Score = 57.8 bits (138), Expect = 8e-08
Identities = 83/339 (24%), Positives = 128/339 (37%), Gaps = 64/339 (18%)
Query: 1154 FQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHNLEKPQRMSIPCLV 1213
+++ L+ C +A C GV + CV DG V C+ L +P+ + C
Sbjct: 566 YRWKLSSHEPC----SATCTTGVMSAYAMCVRYDGVEVDDSYCDA--LTRPEPVHEFCAG 619
Query: 1214 -ECVVNCQLSGWTAWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPTELTQ--------- 1263
EC + S +W+ECS+TCG G + R M + G ++L +
Sbjct: 620 RECQPRWETS---SWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEE 676
Query: 1264 EKTCPVTPCY-SWVLGNWSACKLEGGDCGE-GVQIRSLSCMVHSGSISHAAGRVEDALCG 1321
KTC C W + WS C + CGE V R + C ++ LC
Sbjct: 677 RKTCRNPACGPQWEMSEWSECTAK---CGERSVVTRDIRCSE------------DEKLCD 721
Query: 1322 EMPFQDSILKQLCSVPCPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQSFE 1381
P + ++ C+ P P D T S+W C +C GR+ V ++ + +S
Sbjct: 722 --PNTRPVGEKNCTGP-PCDRQWTV-SDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQC 777
Query: 1382 NQDSCPQQVLETRPCTGGKCYHYTWKASLWNN---------NERTVWC-QRSDGVNVTGG 1431
++ P L PC C + W A W +R V C + ++G T
Sbjct: 778 QMETKP---LAIHPCGDKNCPAH-WLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRS 833
Query: 1432 ---CS-----PQARPAAIRQCIPACRKPFSYCTQGGVCG 1462
C P+ R C P+S CT+ CG
Sbjct: 834 GPECGLAKKPPEESTCFERPCFKWYTSPWSECTK--TCG 870
Score = 55.5 bits (132), Expect = 4e-07
Identities = 52/192 (27%), Positives = 71/192 (36%), Gaps = 40/192 (20%)
Query: 18 WGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCF-RVCDWHSDLFQWE 76
WG C+G CG G R V+C DG S C +P C + C H W
Sbjct: 746 WGPCSGSCGQGRT-IRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAH-----WL 799
Query: 77 VSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICE-HFALQP 135
DW C T G++ R+V C++ N E A +P
Sbjct: 800 AQDWERCN----------------TTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKP 843
Query: 136 PTEQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPNLTE-SRA 194
P E C R C PWS C+K CG ++ R ++C T+ R
Sbjct: 844 PEESTCF---ERPCFKWYTSPWSECTKTCGVGVRMR-----------DVKCYQGTDIVRG 889
Query: 195 CDAPISCPLGEE 206
CD P+ P+G +
Sbjct: 890 CD-PLVKPVGRQ 900
Score = 51.6 bits (122), Expect = 6e-06
Identities = 44/153 (28%), Positives = 62/153 (40%), Gaps = 33/153 (21%)
Query: 1 MHNTADEVVLYHKLAGPWGRCTGDCGPGGVQSRAVWCFHVDG---WTSHLSNCGESNRPP 57
+H D+ H LA W RC CG GV+ R V C + T CG + +PP
Sbjct: 786 IHPCGDKNCPAHWLAQDWERCNTTCG-RGVKKRLVLCMELANGKPQTRSGPECGLAKKPP 844
Query: 58 KERSCF-RVCDWHSDLFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQ 116
+E +CF R C F+W S W C T G++ R V+C Q
Sbjct: 845 EESTCFERPC------FKWYTSPWSECT----------------KTCGVGVRMRDVKCYQ 882
Query: 117 KLNRTVVANEICEHFALQPPTEQAC-LIPCPRD 148
+ + + ++P QAC L PCP +
Sbjct: 883 GTDIVRGCDPL-----VKPVGRQACDLQPCPTE 910
Score = 44.7 bits (104), Expect = 7e-04
Identities = 41/156 (26%), Positives = 62/156 (39%), Gaps = 38/156 (24%)
Query: 18 WGRCTGDCGPGGVQSRAVWCFHV------DGWTSHLSNCGESNRPPKERSCFRVCDWHSD 71
W C+ CG G Q R V C+ + S L E+ RP + ++C
Sbjct: 631 WSECSRTCGEG-YQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGP-- 687
Query: 72 LFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHF 131
QWE+S+W C TA+C + + R +RC + ++C+
Sbjct: 688 --QWEMSEWSEC-------------TAKC--GERSVVTRDIRCSED-------EKLCDP- 722
Query: 132 ALQPPTEQACL-IPCPRDCVVSEFLPWSNCSKGCGK 166
+P E+ C PC R VS+ W CS CG+
Sbjct: 723 NTRPVGEKNCTGPPCDRQWTVSD---WGPCSGSCGQ 755
Score = 37.7 bits (86), Expect = 0.088
Identities = 48/210 (22%), Positives = 72/210 (34%), Gaps = 31/210 (14%)
Query: 1273 YSWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSILKQ 1332
Y W L + C C GV C+ + G V+D+ C + + + +
Sbjct: 566 YRWKLSSHEPCS---ATCTTGVMSAYAMCVRYDGV------EVDDSYCDALTRPEPVHEF 616
Query: 1333 LCSVPCPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQSFEN---QDSCPQ- 1388
C E S WS C TC +G F V R + F++ D C
Sbjct: 617 CAGRECQPRW---ETSSWSECSRTCGEGYQFRVV----RCWKMLSPGFDSSVYSDLCEAA 669
Query: 1389 ---QVLETRPCTGGKCYHYTWKASLWNN-----NERTVWCQRSDGVNVTGGCSPQARPAA 1440
+ E + C C W+ S W+ ER+V + C P RP
Sbjct: 670 EAVRPEERKTCRNPAC-GPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVG 728
Query: 1441 IRQCI-PACRKPFSYCTQGGVCG-CEKGYT 1468
+ C P C + ++ G G C +G T
Sbjct: 729 EKNCTGPPCDRQWTVSDWGPCSGSCGQGRT 758
Score = 33.1 bits (74), Expect = 2.2
Identities = 15/56 (26%), Positives = 28/56 (50%), Gaps = 3/56 (5%)
Query: 575 EWTEWSSCSQSC-SNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHRLCNDHSC 629
EWT+W++CS+SC S + + ++ G G + C + + ++LC C
Sbjct: 52 EWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTS--KRYQLCRVQEC 105
Score = 32.0 bits (71), Expect = 4.9
Identities = 19/54 (35%), Positives = 26/54 (48%), Gaps = 6/54 (11%)
Query: 1224 WTAWTECSQTCGHGGRMSRTRFIIMPTQ----GEG-RPCPTELTQEKTCPVTPC 1272
WT WT CS++CG GG S+ R + + G G R C + + C V C
Sbjct: 53 WTKWTACSRSCG-GGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQEC 105
>gi|169174934 PREDICTED: similar to ADAMTS-like 2 [Homo sapiens]
Length = 660
Score = 102 bits (254), Expect = 3e-21
Identities = 110/386 (28%), Positives = 158/386 (40%), Gaps = 70/386 (18%)
Query: 976 SSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKL--DLKNQAQVHEAVPCYSECNQYSW 1033
SS CS++C GV S + Y+G L VHE C Q W
Sbjct: 280 SSHEPCSATCTTGVM--SAYAMCVRYDGVEVDDSYCDALTRPEPVHEF--CAGRECQPRW 335
Query: 1034 VVEHWSSCKINNELRSLRCGGGTQSRKIRCVNT-ADGEGGAVDSNLCNQDEI--PPETQS 1090
WS C S CG G Q R +RC + G +V S+LC E P E ++
Sbjct: 336 ETSSWSEC-------SRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKT 388
Query: 1091 C-SLMCPNECVMSEWGLWSKCPQSCDPHTMQRRTRHLLRPSLNSRTCAEDSQVQPCLLNE 1149
C + C + MSEW S+C C ++ R +R S + + C D +P + +
Sbjct: 389 CRNPACGPQWEMSEW---SECTAKCGERSVVTRD---IRCSEDEKLC--DPNTRP-VGEK 439
Query: 1150 NCF----QFQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHNLEKPQ 1205
NC Q+ +++W C S CGQG R + C SDG+ V QC+ KP
Sbjct: 440 NCTGPPCDRQWTVSDWGPCSGS----CGQGRTIRHVYCKTSDGRVVPESQCQMET--KPL 493
Query: 1206 RMSIPCLVECVVNCQLSGWTA--WTECSQTCGHGGRMSRTRFIIMPTQGEGRP------- 1256
+ PC + NC + W A W C+ TCG G + R ++ G+P
Sbjct: 494 AIH-PCGDK---NCP-AHWLAQDWERCNTTCGRG---VKKRLVLCMELANGKPQTRSGPE 545
Query: 1257 --CPTELTQEKTCPVTPCYSWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGR 1314
+ +E TC PC+ W WS C CG GV++R + C + G+
Sbjct: 546 CGLAKKPPEESTCFERPCFKWYTSPWSECT---KTCGVGVRMRDVKC--YQGT------- 593
Query: 1315 VEDALCGEMPFQDSILKQLCSV-PCP 1339
D + G P + +Q C + PCP
Sbjct: 594 --DIVRGCDPLVKPVGRQACDLQPCP 617
Score = 85.5 bits (210), Expect = 4e-16
Identities = 106/429 (24%), Positives = 151/429 (35%), Gaps = 107/429 (24%)
Query: 301 IMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVE 360
+ P D + SS PCS TC +G + + + V++ + + L + + E
Sbjct: 269 VSPADMYRWKLSSHEPCSATCTTGVM----SAYAMCVRYDGVEVDDSYCDALTRPEPVHE 324
Query: 361 GELLQQC-PRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYC-------A 412
++C PR W TS W EC CG G Q R V C
Sbjct: 325 FCAGRECQPR--WETSSWSEC----------------SRTCGEGYQFRVVRCWKMLSPGF 366
Query: 413 QSVPAAAALRAKEVSRPVEKALCVGPAPLPSQLCNIPCSTDCIVSSWSAWGLCIHENCHD 472
S + A E RP E+ C PA C +S WS C
Sbjct: 367 DSSVYSDLCEAAEAVRPEERKTCRNPA----------CGPQWEMSEWS--------ECTA 408
Query: 473 PQGKKGFRTR------QRHVLMESTGPAGHCPHLVESVPCEDPMCYR-WLASEGICFPDH 525
G++ TR + +T P G C P C R W S+ P
Sbjct: 409 KCGERSVVTRDIRCSEDEKLCDPNTRPVG-------EKNCTGPPCDRQWTVSD--WGPCS 459
Query: 526 GKCGLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSCEI-PCRMDCVLSEW--TEWSSC 582
G CG G I C+ G V S C + E K I PC + W +W C
Sbjct: 460 GSCGQGRTIRHVYCKTSDGRVVPESQCQM----ETKPLAIHPCGDKNCPAHWLAQDWERC 515
Query: 583 SQSCSNKNSDGKQTRSRTILALAGEGGKP-------CPPSQALQEHRLCNDHSCMQLHWE 635
+ +C G+ + R +L + GKP C ++ E C + C + W
Sbjct: 516 NTTC------GRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFK--WY 567
Query: 636 TSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPET 695
TSPW C++ TCGVG++ R V C + G + + C +P
Sbjct: 568 TSPWSECTK-----------------TCGVGVRMRDVKC---YQGTDIVRGCDPLVKPVG 607
Query: 696 VRPCFL-PC 703
+ C L PC
Sbjct: 608 RQACDLQPC 616
Score = 81.3 bits (199), Expect = 7e-15
Identities = 85/366 (23%), Positives = 124/366 (33%), Gaps = 64/366 (17%)
Query: 759 EDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCISDDNRSAEMME 818
+ VS +YRWK PC S C G+ + C+ D +
Sbjct: 267 QGVSPADMYRWKLSSHEPC--------------SATCTTGVMSAYAMCVRYDGVEVDDSY 312
Query: 819 CLKQTNGMPLLVQECTVPCREDCTFTAWSKFTPCSTNCEATKSRRRQLTGK--------S 870
C T P+ C+ ++WS+ CS C R K S
Sbjct: 313 CDALTRPEPVHEFCAGRECQPRWETSSWSE---CSRTCGEGYQFRVVRCWKMLSPGFDSS 369
Query: 871 RKKEKCQDSDLYPLVETELCPCDEFISQ-PYGNWSDCILPEGRREP-HRGLRVQADSKEC 928
+ C+ ++ E + C Q WS+C G R R +R D K C
Sbjct: 370 VYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLC 429
Query: 929 GEGLRFRAVACSDKNGRPVDPSFCSSSGYIQEKCVIPCPFDCKLSDWSSWGSCSSSCGIG 988
D N RPV C+ PC +SDW G CS SCG G
Sbjct: 430 ------------DPNTRPVGEKNCTGP---------PCDRQWTVSDW---GPCSGSCGQG 465
Query: 989 VRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHEAVPCYSECNQYSWVVEHWSSCKINNELR 1048
IR + K + GR P+ + + + PC + W+ + W C
Sbjct: 466 RTIRHVYCKT---SDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTT---- 518
Query: 1049 SLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEWGLWS 1108
CG G + R + C+ A+G+ C + PPE +C C WS
Sbjct: 519 ---CGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTC---FERPCFKWYTSPWS 572
Query: 1109 KCPQSC 1114
+C ++C
Sbjct: 573 ECTKTC 578
Score = 76.3 bits (186), Expect = 2e-13
Identities = 93/379 (24%), Positives = 132/379 (34%), Gaps = 94/379 (24%)
Query: 449 PCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVESVP--- 505
PCS C SA+ +C+ R V ++ + +C L P
Sbjct: 284 PCSATCTTGVMSAYAMCV---------------RYDGVEVDDS----YCDALTRPEPVHE 324
Query: 506 -CEDPMCY-RWLASE-GICFPDHGKCGLGHRILKAVCQNDRGEDVS--GSLCPVPP---P 557
C C RW S C G+ G R+++ G D S LC P
Sbjct: 325 FCAGRECQPRWETSSWSECSRTCGE-GYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRP 383
Query: 558 PERKSCEIP-CRMDCVLSEWTEWSSCSQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQ 616
ERK+C P C +SEW+E C+ C ++ + R E K C P+
Sbjct: 384 EERKTCRNPACGPQWEMSEWSE---CTAKCGERSVVTRDIR-------CSEDEKLCDPNT 433
Query: 617 ALQEHRLCNDHSCMQLHWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVK 676
+ C C + W S WGPCS +CG G R V+C
Sbjct: 434 RPVGEKNCTGPPCDR-QWTVSDWGPCS-----------------GSCGQGRTIRHVYCKT 475
Query: 677 SHVGQVMTKRCPDSTRPETVRPCFLPCKKDCIVTAFS-EWTPCPRMCQAGNATVKQSRYR 735
S V +C T+P + PC K+C + +W C C G +
Sbjct: 476 SDGRVVPESQCQMETKPLAIHPC---GDKNCPAHWLAQDWERCNTTCGRG-----VKKRL 527
Query: 736 IIIQEAANG------GQEC--PDTLYEERECEDVSLCPVYRWKPQKWSPCILVPESVWQG 787
++ E ANG G EC EE C + P ++W WS C
Sbjct: 528 VLCMELANGKPQTRSGPECGLAKKPPEESTCFE---RPCFKWYTSPWSEC---------- 574
Query: 788 ITGSSEACGKGLQTRAVSC 806
++ CG G++ R V C
Sbjct: 575 ----TKTCGVGVRMRDVKC 589
Score = 73.9 bits (180), Expect = 1e-12
Identities = 110/454 (24%), Positives = 159/454 (35%), Gaps = 119/454 (26%)
Query: 21 CTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFRVCDWHSDLFQWEVSDW 80
C+ C G V S C DG S C RP C +WE S W
Sbjct: 285 CSATCTTG-VMSAYAMCVRYDGVEVDDSYCDALTRP---EPVHEFCAGRECQPRWETSSW 340
Query: 81 HHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNR---TVVANEICEHF-ALQPP 136
C T G Q R+VRC + L+ + V +++CE A++P
Sbjct: 341 SECSR----------------TCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPE 384
Query: 137 TEQACLIP-CPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPNLTESRAC 195
+ C P C +SE WS C+ CG+ R+V+ ++C + + C
Sbjct: 385 ERKTCRNPACGPQWEMSE---WSECTAKCGE------RSVVT----RDIRCSE--DEKLC 429
Query: 196 DAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGR--TVLDFNSDSNERVTFKHQSY 253
D P + P+GE+ T GP P R TV D+ S
Sbjct: 430 D-PNTRPVGEKNCT-----GP-------------PCDRQWTVSDWGPCSG---------- 460
Query: 254 KAHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCETSQW-- 311
+ G R V C SDG+ S C ++ PL + C K+C + W
Sbjct: 461 ---------SCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPC-GDKNC-PAHWLA 509
Query: 312 SSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIV-----EGELLQQ 366
W C+ TC G + R V M + GK P+ C + E +
Sbjct: 510 QDWERCNTTCGRG-------VKKRLVLCMELANGK--PQTRSGPECGLAKKPPEESTCFE 560
Query: 367 CPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEV 426
P + W TS W EC CG G++ R+V C Q +
Sbjct: 561 RPCFKWYTSPWSECT----------------KTCGVGVRMRDVKCYQGTDIVRG--CDPL 602
Query: 427 SRPVEKALC-VGPAPL--PSQLCNIPCSTDCIVS 457
+PV + C + P P P C T+C ++
Sbjct: 603 VKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALA 636
Score = 65.5 bits (158), Expect = 4e-10
Identities = 98/424 (23%), Positives = 151/424 (35%), Gaps = 111/424 (26%)
Query: 634 WETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRP 693
W+ S PCS ATC G+ + CV+ +V C TRP
Sbjct: 277 WKLSSHEPCS-----------------ATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRP 319
Query: 694 ETVRPCFLPCKKDCIVTAFSEWTPCPRMCQAG------------NATVKQSRYRIIIQEA 741
E V F ++ S W+ C R C G + S Y + + A
Sbjct: 320 EPVHE-FCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAA 378
Query: 742 ANGGQECPDTLYEERECEDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACG-KGLQ 800
E E + C + + P +W+ +WS C + CG + +
Sbjct: 379 EAVRPE------ERKTCRNPACGP--QWEMSEWSEC--------------TAKCGERSVV 416
Query: 801 TRAVSCISDDNRSAEMMECLKQTNGMPLLVQECT-VPCREDCTFTAWSKFTPCSTNCEAT 859
TR + C D+ L N P+ + CT PC T + W PCS +C
Sbjct: 417 TRDIRCSEDEK--------LCDPNTRPVGEKNCTGPPCDRQWTVSDWG---PCSGSCGQG 465
Query: 860 KSRR----RQLTGKSRKKEKCQDSDLYPLVETELCPCDE------FISQPYGNWSDCILP 909
++ R + G+ + +CQ + PL + PC + +++Q +W C
Sbjct: 466 RTIRHVYCKTSDGRVVPESQCQ-METKPLA---IHPCGDKNCPAHWLAQ---DWERC--- 515
Query: 910 EGRREPHRGLRVQADSKECGEGLRFRAVACSD-KNGRPVDPSFCSSSGYIQEKCVIPCPF 968
+ CG G++ R V C + NG+P S G ++ F
Sbjct: 516 ---------------NTTCGRGVKKRLVLCMELANGKPQTRSG-PECGLAKKPPEESTCF 559
Query: 969 DCKLSDW--SSWGSCSSSCGIGVRIRSKWLKEKPYNGG---RPCPKLDLKNQAQVHEAVP 1023
+ W S W C+ +CG+GVR+R K Y G R C L Q + P
Sbjct: 560 ERPCFKWYTSPWSECTKTCGVGVRMRD----VKCYQGTDIVRGCDPLVKPVGRQACDLQP 615
Query: 1024 CYSE 1027
C +E
Sbjct: 616 CPTE 619
Score = 62.4 bits (150), Expect = 3e-09
Identities = 88/358 (24%), Positives = 124/358 (34%), Gaps = 89/358 (24%)
Query: 257 HHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCETS-QWSSWS 315
H S G + C R DG S C + P V ++C+ + SSWS
Sbjct: 282 HEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWS 341
Query: 316 PCSKTCRSG----------SLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEGELLQ 365
CS+TC G L PGF S + + E E++ C
Sbjct: 342 ECSRTCGEGYQFRVVRCWKMLSPGFDSS----VYSDLCEAAEAVRPEERKTC------RN 391
Query: 366 QCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCG-GGIQTREVYCAQSVPAAAALRAK 424
W SEW EC CG + TR++ C++
Sbjct: 392 PACGPQWEMSEWSECTAK----------------CGERSVVTRDIRCSEDEKL-----CD 430
Query: 425 EVSRPVEKALCVGPAPLPSQLCNIPCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQR 484
+RPV + C GP PC VS WG C G G R
Sbjct: 431 PNTRPVGEKNCTGP----------PCDRQWTVSD---WGPC--------SGSCGQGRTIR 469
Query: 485 HVLMESTG----PAGHCPHLVESV---PCEDPMC-YRWLASE-GICFPDHGKCGLGHRIL 535
HV +++ P C + + PC D C WLA + C + CG G +
Sbjct: 470 HVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERC---NTTCGRGVKKR 526
Query: 536 KAVCQ---NDRGEDVSGSLCPV-PPPPERKSC-EIPCRMDCVLSEW--TEWSSCSQSC 586
+C N + + SG C + PPE +C E PC +W + WS C+++C
Sbjct: 527 LVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC------FKWYTSPWSECTKTC 578
Score = 57.8 bits (138), Expect = 8e-08
Identities = 83/339 (24%), Positives = 128/339 (37%), Gaps = 64/339 (18%)
Query: 1154 FQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHNLEKPQRMSIPCLV 1213
+++ L+ C +A C GV + CV DG V C+ L +P+ + C
Sbjct: 275 YRWKLSSHEPC----SATCTTGVMSAYAMCVRYDGVEVDDSYCDA--LTRPEPVHEFCAG 328
Query: 1214 -ECVVNCQLSGWTAWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPTELTQ--------- 1263
EC + S +W+ECS+TCG G + R M + G ++L +
Sbjct: 329 RECQPRWETS---SWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEE 385
Query: 1264 EKTCPVTPCY-SWVLGNWSACKLEGGDCGE-GVQIRSLSCMVHSGSISHAAGRVEDALCG 1321
KTC C W + WS C + CGE V R + C ++ LC
Sbjct: 386 RKTCRNPACGPQWEMSEWSECTAK---CGERSVVTRDIRCSE------------DEKLCD 430
Query: 1322 EMPFQDSILKQLCSVPCPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQSFE 1381
P + ++ C+ P P D T S+W C +C GR+ V ++ + +S
Sbjct: 431 --PNTRPVGEKNCTGP-PCDRQWTV-SDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQC 486
Query: 1382 NQDSCPQQVLETRPCTGGKCYHYTWKASLWNN---------NERTVWC-QRSDGVNVTGG 1431
++ P L PC C + W A W +R V C + ++G T
Sbjct: 487 QMETKP---LAIHPCGDKNCPAH-WLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRS 542
Query: 1432 ---CS-----PQARPAAIRQCIPACRKPFSYCTQGGVCG 1462
C P+ R C P+S CT+ CG
Sbjct: 543 GPECGLAKKPPEESTCFERPCFKWYTSPWSECTK--TCG 579
Score = 55.5 bits (132), Expect = 4e-07
Identities = 52/192 (27%), Positives = 71/192 (36%), Gaps = 40/192 (20%)
Query: 18 WGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCF-RVCDWHSDLFQWE 76
WG C+G CG G R V+C DG S C +P C + C H W
Sbjct: 455 WGPCSGSCGQGRT-IRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAH-----WL 508
Query: 77 VSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICE-HFALQP 135
DW C T G++ R+V C++ N E A +P
Sbjct: 509 AQDWERCN----------------TTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKP 552
Query: 136 PTEQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPNLTE-SRA 194
P E C R C PWS C+K CG ++ R ++C T+ R
Sbjct: 553 PEESTCF---ERPCFKWYTSPWSECTKTCGVGVRMR-----------DVKCYQGTDIVRG 598
Query: 195 CDAPISCPLGEE 206
CD P+ P+G +
Sbjct: 599 CD-PLVKPVGRQ 609
Score = 51.6 bits (122), Expect = 6e-06
Identities = 44/153 (28%), Positives = 62/153 (40%), Gaps = 33/153 (21%)
Query: 1 MHNTADEVVLYHKLAGPWGRCTGDCGPGGVQSRAVWCFHVDG---WTSHLSNCGESNRPP 57
+H D+ H LA W RC CG GV+ R V C + T CG + +PP
Sbjct: 495 IHPCGDKNCPAHWLAQDWERCNTTCG-RGVKKRLVLCMELANGKPQTRSGPECGLAKKPP 553
Query: 58 KERSCF-RVCDWHSDLFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQ 116
+E +CF R C F+W S W C T G++ R V+C Q
Sbjct: 554 EESTCFERPC------FKWYTSPWSECT----------------KTCGVGVRMRDVKCYQ 591
Query: 117 KLNRTVVANEICEHFALQPPTEQAC-LIPCPRD 148
+ + + ++P QAC L PCP +
Sbjct: 592 GTDIVRGCDPL-----VKPVGRQACDLQPCPTE 619
Score = 44.7 bits (104), Expect = 7e-04
Identities = 41/156 (26%), Positives = 62/156 (39%), Gaps = 38/156 (24%)
Query: 18 WGRCTGDCGPGGVQSRAVWCFHV------DGWTSHLSNCGESNRPPKERSCFRVCDWHSD 71
W C+ CG G Q R V C+ + S L E+ RP + ++C
Sbjct: 340 WSECSRTCGEG-YQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGP-- 396
Query: 72 LFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHF 131
QWE+S+W C TA+C + + R +RC + ++C+
Sbjct: 397 --QWEMSEWSEC-------------TAKC--GERSVVTRDIRCSED-------EKLCDP- 431
Query: 132 ALQPPTEQACL-IPCPRDCVVSEFLPWSNCSKGCGK 166
+P E+ C PC R VS+ W CS CG+
Sbjct: 432 NTRPVGEKNCTGPPCDRQWTVSD---WGPCSGSCGQ 464
Score = 37.7 bits (86), Expect = 0.088
Identities = 48/210 (22%), Positives = 72/210 (34%), Gaps = 31/210 (14%)
Query: 1273 YSWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSILKQ 1332
Y W L + C C GV C+ + G V+D+ C + + + +
Sbjct: 275 YRWKLSSHEPCS---ATCTTGVMSAYAMCVRYDGV------EVDDSYCDALTRPEPVHEF 325
Query: 1333 LCSVPCPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQSFEN---QDSCPQ- 1388
C E S WS C TC +G F V R + F++ D C
Sbjct: 326 CAGRECQPRW---ETSSWSECSRTCGEGYQFRVV----RCWKMLSPGFDSSVYSDLCEAA 378
Query: 1389 ---QVLETRPCTGGKCYHYTWKASLWNN-----NERTVWCQRSDGVNVTGGCSPQARPAA 1440
+ E + C C W+ S W+ ER+V + C P RP
Sbjct: 379 EAVRPEERKTCRNPAC-GPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVG 437
Query: 1441 IRQCI-PACRKPFSYCTQGGVCG-CEKGYT 1468
+ C P C + ++ G G C +G T
Sbjct: 438 EKNCTGPPCDRQWTVSDWGPCSGSCGQGRT 467
>gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]
Length = 1151
Score = 101 bits (251), Expect = 7e-21
Identities = 102/350 (29%), Positives = 132/350 (37%), Gaps = 53/350 (15%)
Query: 975 WSSWGSCSSSCGIGVRIRSKWLKEK-PYNGGRPCPKLDLKNQAQVHEAVPCYSECNQYSW 1033
WSSW CS+SCGIG ++R + P +GGR C + + +E PC SW
Sbjct: 670 WSSWALCSTSCGIGFQVRQRSCSNPAPRHGGRICVGKS-REERFCNENTPCPVPIFWASW 728
Query: 1034 VVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIP------PE 1087
WS C N CGGG QSR+ C N G V+ CN + P P
Sbjct: 729 --GSWSKCSSN-------CGGGMQSRRRACENGNSCLGCGVEFKTCNPEGCPEVRRNTPW 779
Query: 1088 TQSCSLMCPNECVMSEWGLWSKC-PQSCDPHTMQ---RRTRHLLRPSLNSRTCAEDSQVQ 1143
T + E C DPH +Q RRT P+ S +C D+ V+
Sbjct: 780 TPWLPVNVTQGGARQEQRFRFTCRAPLADPHGLQFGRRRTETRTCPADGSGSCDTDALVE 839
Query: 1144 PCLLNENCFQFQYN-----LTEWSTCQLSENAPCGQGVRTRLLSCVCSD----GKPVSMD 1194
L + + + WS+C + C G R R +C + G P D
Sbjct: 840 VLLRSGSTSPHTVSGGWAAWGPWSSC----SRDCELGFRVRKRTCTNPEPRNGGLPCVGD 895
Query: 1195 QCEQHNLEKPQRMSIPCLVECVVNCQLSGWTAWTECSQTCGHGGRMSRTRFIIMPTQGEG 1254
E + PQ C V S WT+W+ CS +CG GG RTR P G
Sbjct: 896 AAEYQDC-NPQ--------ACPVRGAWSCWTSWSPCSASCG-GGHYQRTRSCTSPAPSPG 945
Query: 1255 RP-CPTELTQEKTCPVTPC-YSW-VLGNWSACKLEGGDCGEGVQIRSLSC 1301
C T+E C C W WS C +G Q RS C
Sbjct: 946 EDICLGLHTEEALCATQACPEGWSPWSEWSKC------TDDGAQSRSRHC 989
Score = 82.4 bits (202), Expect = 3e-15
Identities = 136/560 (24%), Positives = 190/560 (33%), Gaps = 139/560 (24%)
Query: 907 ILPEGRREPHRGLRVQADSKECGEGLR-------FRAVACSDKNGRPV---DPSFCSSSG 956
+LP GRREP R LR+ ++ GLR A G + DP +C G
Sbjct: 519 VLPPGRREPLRSLRILHSARALFVGLRDGVLRVPLERCAAYRSQGACLGARDP-YCGWDG 577
Query: 957 YIQEKC---------------VIPCPF-----DCKLSDWSSWGSC-------SSSCGIGV 989
Q++C + CP D WS W C S SC
Sbjct: 578 K-QQRCSTLEDSSNMSLWTQNITACPVRNVTRDGGFGPWSPWQPCEHLDGDNSGSCLCRA 636
Query: 990 RIRSKWLKEKPYNGGRPC--PKLDLKNQAQVHEAVPCYSECNQYSWVVEHWSSCKINNEL 1047
R +P GG C P + + N ++ P S W+ C
Sbjct: 637 RSCD---SPRPRCGGLDCLGPAIHIANCSRNGAWTPWSS-----------WALC------ 676
Query: 1048 RSLRCGGGTQSRKIRCVNTADGEGGAV------DSNLCNQDEIPPETQSCSLMCPNECVM 1101
S CG G Q R+ C N A GG + + CN+ + CP
Sbjct: 677 -STSCGIGFQVRQRSCSNPAPRHGGRICVGKSREERFCNE----------NTPCPVPIFW 725
Query: 1102 SEWGLWSKCPQSCDPHTMQRRTRHLLRPSLNSRTCAEDSQVQPCLLNENCFQFQYNLTEW 1161
+ WG WSKC +C RR R N +C E C + + N T W
Sbjct: 726 ASWGSWSKCSSNCGGGMQSRR-----RACENGNSCLGCGVEFKTCNPEGCPEVRRN-TPW 779
Query: 1162 STCQLSENAPCGQGVRTRLLSCVC----SDGKPVSMDQCEQHNLEKPQRMSIPCLVECVV 1217
T L N G + + C +D + + P S C + +V
Sbjct: 780 -TPWLPVNVTQGGARQEQRFRFTCRAPLADPHGLQFGRRRTETRTCPADGSGSCDTDALV 838
Query: 1218 NCQL-----------SGWTA---WTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPTELTQ 1263
L GW A W+ CS+ C G R+ + + G PC + +
Sbjct: 839 EVLLRSGSTSPHTVSGGWAAWGPWSSCSRDCELGFRVRKRTCTNPEPRNGGLPCVGDAAE 898
Query: 1264 -----EKTCPVTPCYS-WVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVED 1317
+ CPV +S W +WS C CG G R+ SC S A ED
Sbjct: 899 YQDCNPQACPVRGAWSCWT--SWSPC---SASCGGGHYQRTRSC------TSPAPSPGED 947
Query: 1318 ALCGEMPFQDSILKQLCSV-PCPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFI 1376
+C + +++ LC+ CP + WSEWS C G QSRSR
Sbjct: 948 -ICLGLHTEEA----LCATQACPEG--WSPWSEWSKC----------TDDGAQSRSR-HC 989
Query: 1377 IQSFENQDSCPQQVLETRPC 1396
+ +C ++RPC
Sbjct: 990 EELLPGSSACAGNSSQSRPC 1009
Score = 76.3 bits (186), Expect = 2e-13
Identities = 98/411 (23%), Positives = 144/411 (35%), Gaps = 56/411 (13%)
Query: 703 CKKDCIVTAFSEWTPCPRMCQAGNATVKQSRYRIIIQEAA-NGGQECPDTLYEERECEDV 761
C ++ T +S W C C G Q R R A +GG+ C EER C +
Sbjct: 661 CSRNGAWTPWSSWALCSTSCGIGF----QVRQRSCSNPAPRHGGRICVGKSREERFCNEN 716
Query: 762 SLCPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCISDDNRSAEMMECLK 821
+ CPV P W+ W + S CG G+Q+R +C + ++ CL
Sbjct: 717 TPCPV----PIFWAS--------WGSWSKCSSNCGGGMQSRRRACENGNS-------CL- 756
Query: 822 QTNGMPLLVQECTVP-CREDCTFTAWSKFTPCS-TNCEATKSRRRQLTGKSRKKEKCQDS 879
G + + C C E T W+ + P + T A + +R + T ++ +
Sbjct: 757 ---GCGVEFKTCNPEGCPEVRRNTPWTPWLPVNVTQGGARQEQRFRFTCRAPLADPHGLQ 813
Query: 880 DLYPLVETELCPCDEFISQPYGNWSDCILPEGRREPHRGLRVQAD-------SKECGEGL 932
ET CP D S + +L G PH A S++C G
Sbjct: 814 FGRRRTETRTCPADGSGSCDTDALVEVLLRSGSTSPHTVSGGWAAWGPWSSCSRDCELGF 873
Query: 933 RFRAVACSDKNGRPVDPSFCSSSGYIQEKCVIPCPFDCKLSDWSSWGSCSSSCGIGVRIR 992
R R C++ R + Q+ CP S W+SW CS+SCG G
Sbjct: 874 RVRKRTCTNPEPRNGGLPCVGDAAEYQDCNPQACPVRGAWSCWTSWSPCSASCGGG---- 929
Query: 993 SKWLKEKPYNGGRPCPKLDLKNQAQVHEAVPCYSECNQYSWVVEHWSSCKINNELRSLRC 1052
+ + + P P D+ EA+ C + WS C
Sbjct: 930 -HYQRTRSCTSPAPSPGEDICLGLHTEEALCATQACPEGWSPWSEWSKC----------T 978
Query: 1053 GGGTQSRKIRCVNTADGE----GGAVDSNLCNQDEIPPETQSCSLMCPNEC 1099
G QSR C G G + S C EIP + S+ +C
Sbjct: 979 DDGAQSRSRHCEELLPGSSACAGNSSQSRPCPYSEIPVILPASSMEEATDC 1029
Score = 69.7 bits (169), Expect = 2e-11
Identities = 112/467 (23%), Positives = 158/467 (33%), Gaps = 111/467 (23%)
Query: 459 WSAWGLCIH-------------ENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVESVP 505
WS W C H +C P+ + G ++ GPA H +
Sbjct: 615 WSPWQPCEHLDGDNSGSCLCRARSCDSPRPRCGG--------LDCLGPAIHIAN------ 660
Query: 506 CEDPMCYRWLASEGICFPDHGKCGLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSCE- 564
C + +S +C CG+G ++ + C N G +C V E + C
Sbjct: 661 CSRNGAWTPWSSWALCSTS---CGIGFQVRQRSCSNPAPRH-GGRIC-VGKSREERFCNE 715
Query: 565 -IPCRMDCVLSEWTEWSSCSQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHRL 623
PC + + W WS CS +C G Q+R R A E G C E +
Sbjct: 716 NTPCPVPIFWASWGSWSKCSSNCGG----GMQSRRR-----ACENGNSCLGCGV--EFKT 764
Query: 624 CNDHSCMQLHWET--SPWGPCSEDTLVTALNATIGWNGEATCGV------GIQ-----TR 670
CN C ++ T +PW P + VT A TC G+Q T
Sbjct: 765 CNPEGCPEVRRNTPWTPWLPVN----VTQGGARQEQRFRFTCRAPLADPHGLQFGRRRTE 820
Query: 671 RVFCVKSHVGQVMTKRCPD------STRPETVRPCFLPCKKDCIVTAFSEWTPCPRMCQA 724
C G T + ST P TV + A+ W+ C R C+
Sbjct: 821 TRTCPADGSGSCDTDALVEVLLRSGSTSPHTVSGGW---------AAWGPWSSCSRDCEL 871
Query: 725 GNATVKQSRYRIIIQEAANGGQECPDTLYEERECEDVSLCPVY-RWKP-QKWSPCILVPE 782
G K++ E NGG C E ++C + CPV W WSPC
Sbjct: 872 GFRVRKRT---CTNPEPRNGGLPCVGDAAEYQDC-NPQACPVRGAWSCWTSWSPC----- 922
Query: 783 SVWQGITGSSEACGKGLQTRAVSCISDDNRSAEMMECLKQTNGMPLLVQECTVPCREDCT 842
S +CG G R SC S E + CL L T C E
Sbjct: 923 ---------SASCGGGHYQRTRSCTSPAPSPGEDI-CLGLHTEEALC---ATQACPEG-- 967
Query: 843 FTAWSKFTPC--------STNCEATKSRRRQLTGKSRKKEKCQDSDL 881
++ WS+++ C S +CE G S + C S++
Sbjct: 968 WSPWSEWSKCTDDGAQSRSRHCEELLPGSSACAGNSSQSRPCPYSEI 1014
Score = 66.2 bits (160), Expect = 2e-10
Identities = 111/484 (22%), Positives = 167/484 (34%), Gaps = 103/484 (21%)
Query: 820 LKQTNGMPLLVQECTV-PCRE---DCTFTAWSKFTPCS----TNCEATKSRRRQLTGKSR 871
L+ ++ M L Q T P R D F WS + PC N + R R
Sbjct: 585 LEDSSNMSLWTQNITACPVRNVTRDGGFGPWSPWQPCEHLDGDNSGSCLCRARSCDSP-- 642
Query: 872 KKEKCQDSD-LYPLVETELCPCDEFISQPYGNWSDCILPEGRREPHRGLRVQADSKECGE 930
+ +C D L P + C + + P+ +W+ C S CG
Sbjct: 643 -RPRCGGLDCLGPAIHIANCSRNGAWT-PWSSWALC------------------STSCGI 682
Query: 931 GLRFRAVACSDKN---------GRPVDPSFCSSSGYIQEKCVIPCPFDCKLSDWSSWGSC 981
G + R +CS+ G+ + FC+ + PCP + W SW C
Sbjct: 683 GFQVRQRSCSNPAPRHGGRICVGKSREERFCNEN--------TPCPVPIFWASWGSWSKC 734
Query: 982 SSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHEAVPCYSECNQYS-WVVEHWSS 1040
SS+CG G++ R + G C ++ + E P ++ W+ + +
Sbjct: 735 SSNCGGGMQSR-----RRACENGNSCLGCGVEFKTCNPEGCPEVRRNTPWTPWLPVNVTQ 789
Query: 1041 CKINNELR-------SLRCGGGTQSRKIRCVN---TADGEGG----AVDSNLCNQDEIPP 1086
E R L G Q + R ADG G A+ L P
Sbjct: 790 GGARQEQRFRFTCRAPLADPHGLQFGRRRTETRTCPADGSGSCDTDALVEVLLRSGSTSP 849
Query: 1087 ETQSCSLMCPNECVMSEWGLWSKCPQSCD-PHTMQRRTRHLLRPSLNSRTCAED-SQVQP 1144
T S + WG WS C + C+ +++RT P C D ++ Q
Sbjct: 850 HTVSGG--------WAAWGPWSSCSRDCELGFRVRKRTCTNPEPRNGGLPCVGDAAEYQD 901
Query: 1145 CLLNENCFQFQYNL-TEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHNLEK 1203
C + ++ T WS C +A CG G R SC P D C + E+
Sbjct: 902 CNPQACPVRGAWSCWTSWSPC----SASCGGGHYQRTRSCTSPAPSP-GEDICLGLHTEE 956
Query: 1204 PQRMSIPCLVECVVNCQLSGWTAWTECSQTCGHGGRMSRTRFI--IMP-------TQGEG 1254
C GW+ W+E S+ C G SR+R ++P +
Sbjct: 957 ---------ALCATQACPEGWSPWSEWSK-CTDDGAQSRSRHCEELLPGSSACAGNSSQS 1006
Query: 1255 RPCP 1258
RPCP
Sbjct: 1007 RPCP 1010
Score = 58.9 bits (141), Expect = 4e-08
Identities = 140/606 (23%), Positives = 195/606 (32%), Gaps = 168/606 (27%)
Query: 267 GYQTRQVSC-TRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCETSQWSSWSPCSKT--CRS 323
G+ +Q C T D N +SL Q+ V++ + +D WS W PC S
Sbjct: 574 GWDGKQQRCSTLEDSSN--MSLWTQNITACPVRN--VTRDGGFGPWSPWQPCEHLDGDNS 629
Query: 324 GSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEGELLQQCPRYSWRT--SEWKECQ 381
GS L R+RS + GG C+ + C R T S W C
Sbjct: 630 GSCL--CRARSCDSPRPRCGG----------LDCLGPAIHIANCSRNGAWTPWSSWALCS 677
Query: 382 VSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKALCVGPAPL 441
S CG G Q R+ C+ P +CVG +
Sbjct: 678 TS----------------CGIGFQVRQRSCSNPAPRHGG------------RICVGKS-R 708
Query: 442 PSQLC--NIPCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQR-----------HVLM 488
+ C N PC +SW +W C NC G ++R+R V
Sbjct: 709 EERFCNENTPCPVPIFWASWGSWSKC-SSNCGG-----GMQSRRRACENGNSCLGCGVEF 762
Query: 489 ESTGPAGHCPHLVESVP-------------CEDPMCYRWLASEGICFPDHGKCGLGHRIL 535
++ P G CP + + P +R+ + P HG R
Sbjct: 763 KTCNPEG-CPEVRRNTPWTPWLPVNVTQGGARQEQRFRFTCRAPLADP-HGLQFGRRRTE 820
Query: 536 KAVCQNDRGEDVSGSLCPVPPPPE---RKSCEIPCRMDCVLSEWTEWSSCSQSCSNKNSD 592
C D SGS C E R P + + W WSSCS+ C
Sbjct: 821 TRTCP----ADGSGS-CDTDALVEVLLRSGSTSPHTVSGGWAAWGPWSSCSRDCEL---- 871
Query: 593 GKQTRSRTIL-ALAGEGGKPCPPSQALQEHRLCNDHSC-MQLHWET-SPWGPCSED---- 645
G + R RT GG PC A E++ CN +C ++ W + W PCS
Sbjct: 872 GFRVRKRTCTNPEPRNGGLPCVGDAA--EYQDCNPQACPVRGAWSCWTSWSPCSASCGGG 929
Query: 646 --TLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPETVRPCFLPC 703
+ + GE C +G+ T C T+ CP+ P
Sbjct: 930 HYQRTRSCTSPAPSPGEDIC-LGLHTEEALCA--------TQACPEGWSP---------- 970
Query: 704 KKDCIVTAFSEWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQECPDTLYEERECEDVSL 763
+SEW+ C + +SR+ +E G C + R C
Sbjct: 971 --------WSEWSKC-----TDDGAQSRSRH---CEELLPGSSACAGNSSQSRPC----- 1009
Query: 764 CPVYRWKPQKWSPCILVPESVWQG------------ITGSSEACGKGLQTRAV--SCISD 809
P P IL S+ + TG S G GL T AV SC
Sbjct: 1010 -------PYSEIPVILPASSMEEATDCAGFNLIHLVATGISCFLGSGLLTLAVYLSCQHC 1062
Query: 810 DNRSAE 815
+S E
Sbjct: 1063 QRQSQE 1068
Score = 57.0 bits (136), Expect = 1e-07
Identities = 90/361 (24%), Positives = 130/361 (36%), Gaps = 99/361 (27%)
Query: 144 PCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPNL-TESRACDAPISCP 202
PCP + + WS CS CG +Q R RA G C E + C+ P CP
Sbjct: 718 PCPVPIFWASWGSWSKCSSNCGGGMQSRRRACE-----NGNSCLGCGVEFKTCN-PEGCP 771
Query: 203 LGEEEYTFSLKVGPWSK-----------------CRLPHLKEINPSG------RTVL--- 236
E + PW CR P +P G RT
Sbjct: 772 ----EVRRNTPWTPWLPVNVTQGGARQEQRFRFTCRAPLA---DPHGLQFGRRRTETRTC 824
Query: 237 ------DFNSDSNERVTFKHQSYKAHHHSKSWAI-----------EIGYQTRQVSCTRSD 279
++D+ V + S H S WA E+G++ R+ +CT +
Sbjct: 825 PADGSGSCDTDALVEVLLRSGSTSPHTVSGGWAAWGPWSSCSRDCELGFRVRKRTCTNPE 884
Query: 280 GQNAMLSLCLQDSFPLTVQSCIMPKDCET----SQWSSWSPCSKTCRSGSLLPGFRSRSR 335
+N L C+ D+ Q C P+ C S W+SWSPCS +C G R+R
Sbjct: 885 PRNGGLP-CVGDA--AEYQDC-NPQACPVRGAWSCWTSWSPCSASCGGGHY-----QRTR 935
Query: 336 NVKHMAIGGGKE-CPELLEKEACIVEGELLQQCPRYSWRTSEWKECQVSLLLEQQDPHWH 394
+ A G++ C L +EA Q CP SEW +C
Sbjct: 936 SCTSPAPSPGEDICLGLHTEEALCA----TQACPEGWSPWSEWSKC-------------- 977
Query: 395 VTGPVCGGGIQTREVYCAQSVPAAAALRA-KEVSRPVEKALCVGPAPLPSQLCNIPCSTD 453
G Q+R +C + +P ++A SRP + P LP+ ++ +TD
Sbjct: 978 -----TDDGAQSRSRHCEELLPGSSACAGNSSQSRPCPYSEI--PVILPAS--SMEEATD 1028
Query: 454 C 454
C
Sbjct: 1029 C 1029
Score = 50.1 bits (118), Expect = 2e-05
Identities = 96/395 (24%), Positives = 127/395 (32%), Gaps = 96/395 (24%)
Query: 261 SWAI-----EIGYQTRQVSCTRS---DGQNAMLSLCLQDSFPLTVQSCIMPKDCETSQWS 312
SWA+ IG+Q RQ SC+ G + ++ F C +P + W
Sbjct: 672 SWALCSTSCGIGFQVRQRSCSNPAPRHGGRICVGKSREERFCNENTPCPVP--IFWASWG 729
Query: 313 SWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPEL-LEKEACIVEGELLQQCPRYS 371
SWS CS C G +SR R A G C +E + C EG CP
Sbjct: 730 SWSKCSSNCGG-----GMQSRRR-----ACENGNSCLGCGVEFKTCNPEG-----CPEVR 774
Query: 372 WRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVE 431
R + W W GG Q + P A + R E
Sbjct: 775 -RNTPWTP-------------WLPVNVTQGGARQEQRFRFTCRAPLADPHGLQFGRRRTE 820
Query: 432 KALCVGPAPLPSQLCNIPCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMEST 491
C PA C TD +V VL+ S
Sbjct: 821 TRTC--PADGSGS-----CDTDALV----------------------------EVLLRSG 845
Query: 492 GPAGHCPHLVESVPCEDPMCYRWLASEGICFPDHGKCGLGHRILKAVCQNDRGEDVSGSL 551
+ PH V W A+ G C LG R+ K C N E +G L
Sbjct: 846 STS---PHTVSG---------GW-AAWGPWSSCSRDCELGFRVRKRTCTNP--EPRNGGL 890
Query: 552 CPVPPPPERKSCE-IPCRMDCVLSEWTEWSSCSQSCSNKNSDGKQTRSRTILALAGEGGK 610
V E + C C + S WT WS CS SC G R+R+ + A G+
Sbjct: 891 PCVGDAAEYQDCNPQACPVRGAWSCWTSWSPCSASCGG----GHYQRTRSCTSPAPSPGE 946
Query: 611 PCPPSQALQEHRLCNDHSCMQLHWETSPWGPCSED 645
+E LC +C + S W C++D
Sbjct: 947 DICLGLHTEE-ALCATQACPEGWSPWSEWSKCTDD 980
Score = 49.3 bits (116), Expect = 3e-05
Identities = 93/413 (22%), Positives = 133/413 (32%), Gaps = 115/413 (27%)
Query: 145 CPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAP-PLFGGLQCPNLT-ESRACDAPISCP 202
C R+ + + W+ CS CG Q R R+ P P GG C + E R C+ CP
Sbjct: 661 CSRNGAWTPWSSWALCSTSCGIGFQVRQRSCSNPAPRHGGRICVGKSREERFCNENTPCP 720
Query: 203 LGEEEYTFSLKVGPWSKCRL-----------------------PHLKEINPSG------- 232
+ F G WSKC K NP G
Sbjct: 721 VP----IFWASWGSWSKCSSNCGGGMQSRRRACENGNSCLGCGVEFKTCNPEGCPEVRRN 776
Query: 233 --------RTVLDFNSDSNERVTFKHQSYKAHHHSKSWAIEIGYQTRQVSCTRSDGQ--- 281
V + +R F ++ A H ++ G + + +DG
Sbjct: 777 TPWTPWLPVNVTQGGARQEQRFRFTCRAPLADPH----GLQFGRRRTETRTCPADGSGSC 832
Query: 282 --NAMLSLCLQ--DSFPLTVQSCIMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNV 337
+A++ + L+ + P TV + W WS CS+ C GFR R R
Sbjct: 833 DTDALVEVLLRSGSTSPHTVSG-------GWAAWGPWSSCSRDCEL-----GFRVRKRTC 880
Query: 338 KH-MAIGGGKEC-PELLEKEACIVEGELLQQCP-RYSWRT-SEWKECQVSLLLEQQDPHW 393
+ GG C + E + C Q CP R +W + W C S
Sbjct: 881 TNPEPRNGGLPCVGDAAEYQDCNP-----QACPVRGAWSCWTSWSPCSAS---------- 925
Query: 394 HVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKALCVGPAPLPSQLCNIPCSTD 453
CGGG R C P+ + E+ALC +Q C
Sbjct: 926 ------CGGGHYQRTRSCTSPAPSPGEDIC--LGLHTEEALCA------TQACPEGW--- 968
Query: 454 CIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVESVPC 506
S WS W C + G ++R RH G + + +S PC
Sbjct: 969 ---SPWSEWSKCTDD---------GAQSRSRHCEELLPGSSACAGNSSQSRPC 1009
>gi|94536854 thrombospondin, type I, domain containing 4 [Homo
sapiens]
Length = 1018
Score = 96.7 bits (239), Expect = 2e-19
Identities = 89/336 (26%), Positives = 135/336 (40%), Gaps = 58/336 (17%)
Query: 1049 SLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIP-PETQSCSLM-CPNECVMSEWGL 1106
S CG G+Q RCV+ + E + C+ P PE + C++ CP + G
Sbjct: 630 STTCGKGSQYPIFRCVHRSTHE--EAPESYCDSSMKPTPEEEPCNIFPCP---AFWDIGE 684
Query: 1107 WSKCPQSCDPHTMQRRT--------RHLLRPSLNSRTCAEDSQVQPCLLNENCFQFQYNL 1158
WS+C ++C R+ R L + + C L + C ++Q
Sbjct: 685 WSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQL-KICSEWQIR- 742
Query: 1159 TEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHNLEKPQRMSIPCLVECVVN 1218
T+W++C + PCG G RTR + CV + G V ++C +P + + C +
Sbjct: 743 TDWTSCSV----PCGVGQRTRDVKCVSNIGDVVDDEECNMKL--RPNDIENCDMGPCAKS 796
Query: 1219 CQLSGWTAWTECSQTCGHGGRMSRTRFII--------MPTQGEGRPCPTELTQEKTCPVT 1270
L+ W+ CS CG G RTR ++ +P +G G P E T P T
Sbjct: 797 WFLTEWSE--RCSAECGAG---VRTRSVVCMTNHVSSLPLEGCGNNRPAEATPCDNGPCT 851
Query: 1271 PCYSWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSIL 1330
W G+WS C +E CG G Q R + C+ + E + + P Q S
Sbjct: 852 GKVEWFAGSWSQCSIE---CGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQS-- 906
Query: 1331 KQLCSVPCPGDCHL----TEW--SEWSTCELTCIDG 1360
CHL +W +EWS C +C G
Sbjct: 907 -----------CHLKPCGAKWFSTEWSMCSKSCQGG 931
Score = 93.2 bits (230), Expect = 2e-18
Identities = 109/405 (26%), Positives = 147/405 (36%), Gaps = 82/405 (20%)
Query: 787 GITGSSEACGKGLQTRAVSCISDDNRSAEMMECLKQTNGMPLLVQE-CTV-PCREDCTFT 844
G T S CGKG Q C+ E E ++ P +E C + PC
Sbjct: 625 GTTECSTTCGKGSQYPIFRCVHRSTHE-EAPESYCDSSMKPTPEEEPCNIFPCPAFWDIG 683
Query: 845 AWSKFTPCSTNCEATKSRRRQLTGK-------SRKKEKCQDSDLYPLVET-ELCPCDEFI 896
WS+ CS C R+ L + + + +CQ + T +L C E+
Sbjct: 684 EWSE---CSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICSEW- 739
Query: 897 SQPYGNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSDKNGRPVDPSFCSSS- 955
Q +W+ C +P CG G R R V C G VD C+
Sbjct: 740 -QIRTDWTSCSVP------------------CGVGQRTRDVKCVSNIGDVVDDEECNMKL 780
Query: 956 --GYIQEKCVIPCPFDCKLSDWSSWGSCSSSCGIGVRIRS-----KWLKEKPYNG---GR 1005
I+ + PC L++WS CS+ CG GVR RS + P G R
Sbjct: 781 RPNDIENCDMGPCAKSWFLTEWSE--RCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNR 838
Query: 1006 PCPKLDLKNQAQVHEAVPCYSE--CNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRC 1063
P EA PC + + W WS C S+ CG GTQ R++ C
Sbjct: 839 PA------------EATPCDNGPCTGKVEWFAGSWSQC-------SIECGSGTQQREVIC 879
Query: 1064 VNTADGEGGAVDSNLCNQDEIPPETQSCSLM-CPNECVMSEWGLWSKCPQSCDPHTMQRR 1122
V +D + C+ E PP QSC L C + +E WS C +SC R
Sbjct: 880 VRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGAKWFSTE---WSMCSKSCQGGFRVRE 936
Query: 1123 TRHLLRPSLNSRTC--------AEDSQVQPCL--LNENCFQFQYN 1157
R L S C E Q C+ ++ENC YN
Sbjct: 937 VRCLSDDMTLSNLCDPQLKPEERESCNPQDCVPEVDENCKDKYYN 981
Score = 90.1 bits (222), Expect = 2e-17
Identities = 98/416 (23%), Positives = 162/416 (38%), Gaps = 52/416 (12%)
Query: 905 DCILPEGRREPHRG-------LRVQADSKECGEGLRFRAVACSDKNGRPVDP-SFCSSSG 956
D ++P + P R L S CG+G ++ C ++ P S+C SS
Sbjct: 603 DNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSM 662
Query: 957 YI---QEKC-VIPCPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDL 1012
+E C + PCP + +WS CS +CG+G++ R ++ N
Sbjct: 663 KPTPEEEPCNIFPCPAFWDIGEWSE---CSKTCGLGMQHRQVLCRQVYANRSLTVQPYRC 719
Query: 1013 KNQAQVHEAVPCYSE-CNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEG 1071
++ + C + C+++ + W+SC S+ CG G ++R ++CV+ G
Sbjct: 720 QHLEKPETTSTCQLKICSEWQ-IRTDWTSC-------SVPCGVGQRTRDVKCVSNI---G 768
Query: 1072 GAVDSNLCNQDEIPPETQSCSL-MCPNECVMSEWGLWSKCPQSCDPHTMQRR----TRHL 1126
VD CN P + ++C + C ++EW +C C R T H+
Sbjct: 769 DVVDDEECNMKLRPNDIENCDMGPCAKSWFLTEWS--ERCSAECGAGVRTRSVVCMTNHV 826
Query: 1127 LRPSLNSRTCAEDSQVQPCLLNENCFQFQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCS 1186
L ++ PC + ++ WS C + CG G + R + CV
Sbjct: 827 SSLPLEGCGNNRPAEATPCDNGPCTGKVEWFAGSWSQCSIE----CGSGTQQREVICVRK 882
Query: 1187 DGKPVS-MDQCEQHNLEKPQRMSIPCLVECVVNCQLSGW--TAWTECSQTCGHGGRMSRT 1243
+ +D E LEKP P C + + W T W+ CS++C G R+
Sbjct: 883 NADTFEVLDPSECSFLEKP-----PSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREV 937
Query: 1244 RFIIMPTQGEGRPCPTELTQE--KTCPVTPCYSWVLGNWSACKLEGGDCGEGVQIR 1297
R + C +L E ++C C V N CK + +C VQ R
Sbjct: 938 R-CLSDDMTLSNLCDPQLKPEERESCNPQDCVPEVDEN---CKDKYYNCNVVVQAR 989
Score = 78.6 bits (192), Expect = 5e-14
Identities = 113/437 (25%), Positives = 167/437 (38%), Gaps = 98/437 (22%)
Query: 436 VGPAPLP---------SQLCNIPCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHV 486
V PAP P QL CST C S C+H + H+
Sbjct: 606 VPPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEE------------- 652
Query: 487 LMESTGPAGHCPHLVESVPCEDPMCYRWLASEGICFPDHGK-------CGLGHRILKAVC 539
P +C ++ P E+P C + F D G+ CGLG + + +C
Sbjct: 653 -----APESYCDSSMKPTPEEEP-CNIFPCP---AFWDIGEWSECSKTCGLGMQHRQVLC 703
Query: 540 QN---DRGEDVSGSLCPVPPPPERKSCEIPCRMDCVLSEW---TEWSSCSQSCSNKNSDG 593
+ +R V C PE S C++ + SEW T+W+SCS C G
Sbjct: 704 RQVYANRSLTVQPYRCQHLEKPETTST---CQLK-ICSEWQIRTDWTSCSVPCGV----G 755
Query: 594 KQTRSRTILALAGEGGKPCPPSQALQEHRLCNDHSC-MQLH---WETSPWGPCSEDTLVT 649
++TR ++ G+ + +D C M+L E GPC++ +T
Sbjct: 756 QRTRDVKCVSNIGD---------------VVDDEECNMKLRPNDIENCDMGPCAKSWFLT 800
Query: 650 ALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPETVRPCFL-PCKKDCI 708
+ A CG G++TR V C+ +HV + + C + RP PC PC
Sbjct: 801 EWSERCS----AECGAGVRTRSVVCMTNHVSSLPLEGC-GNNRPAEATPCDNGPCTGKVE 855
Query: 709 VTAFSEWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQECPDTLYEERECEDVSLCPVYR 768
A S W+ C C +G Q R I +++ A DT E D S C +
Sbjct: 856 WFAGS-WSQCSIECGSGT----QQREVICVRKNA-------DTF----EVLDPSECS-FL 898
Query: 769 WKPQKWSPCILVP-ESVWQGITGS--SEACGKGLQTRAVSCISDDNRSAEMME-CLKQTN 824
KP C L P + W S S++C G + R V C+SDD + + + LK
Sbjct: 899 EKPPSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEE 958
Query: 825 GMPLLVQECTVPCREDC 841
Q+C E+C
Sbjct: 959 RESCNPQDCVPEVDENC 975
Score = 76.3 bits (186), Expect = 2e-13
Identities = 90/334 (26%), Positives = 130/334 (38%), Gaps = 54/334 (16%)
Query: 1139 DSQVQPCLLNENCFQFQ----YNLTEWSTCQLSENAPCGQGVRTRLLSC---VCSDGKPV 1191
DS ++P E C F +++ EWS C + CG G++ R + C + V
Sbjct: 659 DSSMKPTPEEEPCNIFPCPAFWDIGEWSECSKT----CGLGMQHRQVLCRQVYANRSLTV 714
Query: 1192 SMDQCEQHNLEKPQRMSIPCLVECVVNCQLSGW---TAWTECSQTCGHGGRMSRTRFII- 1247
+C+ +LEKP+ S L C S W T WT CS CG G R + +
Sbjct: 715 QPYRCQ--HLEKPETTSTCQLKIC------SEWQIRTDWTSCSVPCGVGQRTRDVKCVSN 766
Query: 1248 MPTQGEGRPCPTELTQE--KTCPVTPCY-SWVLGNWSA-CKLEGGDCGEGVQIRSLSCMV 1303
+ + C +L + C + PC SW L WS C E CG GV+ RS+ CM
Sbjct: 767 IGDVVDDEECNMKLRPNDIENCDMGPCAKSWFLTEWSERCSAE---CGAGVRTRSVVCMT 823
Query: 1304 HSGSISHAAGRVEDALCGEMPFQDSILKQLCSVPCPGDCHLTEW--SEWSTCELTCIDG- 1360
+ S G + P + PC G EW WS C + C G
Sbjct: 824 NHVSSLPLEGCGNNRPAEATPCDNG--------PCTGK---VEWFAGSWSQCSIECGSGT 872
Query: 1361 RSFETVGRQSRSRTFIIQSFEN----QDSCPQQVLETRPCTGGKCYHYTW----KASLWN 1412
+ E + + + TF + + QQ +PC G K + W K+
Sbjct: 873 QQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPC-GAKWFSTEWSMCSKSCQGG 931
Query: 1413 NNERTVWCQRSDGVNVTGGCSPQARPAAIRQCIP 1446
R V C SD + ++ C PQ +P C P
Sbjct: 932 FRVREVRCL-SDDMTLSNLCDPQLKPEERESCNP 964
Score = 67.0 bits (162), Expect = 1e-10
Identities = 94/406 (23%), Positives = 141/406 (34%), Gaps = 86/406 (21%)
Query: 97 TAEC-VTAQHGLQHRMVRCIQKLNRTVVANEICEHFALQPPTEQAC-LIPCPRDCVVSEF 154
T EC T G Q+ + RC+ + C+ P E+ C + PCP + E
Sbjct: 626 TTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAFWDIGE- 684
Query: 155 LPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPNLTESRACDAPISCPLGEEEYTFSLKV 214
WS CSK CG +QHR + C + +R SL V
Sbjct: 685 --WSECSKTCGLGMQHRQ-----------VLCRQVYANR-----------------SLTV 714
Query: 215 GPWSKCRLPHLKEINPSGRTVLDFNSDSNERVTFKHQSYKAHHHSKSWAIEIGYQTRQVS 274
P+ R HL++ + L S+ R + S S +G +TR V
Sbjct: 715 QPY---RCQHLEKPETTSTCQLKICSEWQIRTDWT---------SCSVPCGVGQRTRDVK 762
Query: 275 CTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCETSQWSSWSP-CSKTCRSGSLLPGFRSR 333
C + G C P +++C M ++ + WS CS C +G
Sbjct: 763 CVSNIGDVVDDEECNMKLRPNDIENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCM 822
Query: 334 SRNVKHMAIGGGKECPELLEKEACIVEGELLQQCP-RYSWRTSEWKECQVSLLLEQQDPH 392
+ +V + + G C EA + C + W W +C +
Sbjct: 823 TNHVSSLPLEG---CGNNRPAEATPCDN---GPCTGKVEWFAGSWSQCSIE--------- 867
Query: 393 WHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKALCVGPAPLPSQLCNI-PCS 451
CG G Q REV C + EV P E + P Q C++ PC
Sbjct: 868 -------CGSGTQQREVICVRK-----NADTFEVLDPSECSFL--EKPPSQQSCHLKPCG 913
Query: 452 TDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHC 497
+ WS +C ++C QG GFR R+ L + + C
Sbjct: 914 AKWFSTEWS---MC-SKSC---QG--GFRVREVRCLSDDMTLSNLC 950
Score = 58.9 bits (141), Expect = 4e-08
Identities = 85/335 (25%), Positives = 124/335 (37%), Gaps = 69/335 (20%)
Query: 314 WSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEGELLQQCPRYSWR 373
WS CSKTC G R C L + E L+ C + R
Sbjct: 685 WSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPET--TSTCQLKICSEWQIR 742
Query: 374 TSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKA 433
T +W C V CG G +TR+V C ++ +V E
Sbjct: 743 T-DWTSCSVP----------------CGVGQRTRDVKCVSNI--------GDVVDDEECN 777
Query: 434 LCVGPAPLPSQLCNI-PCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQ-----RHVL 487
+ + P + + C++ PC+ ++ WS E C G G RTR HV
Sbjct: 778 MKLRPNDIEN--CDMGPCAKSWFLTEWS-------ERCSAECG-AGVRTRSVVCMTNHV- 826
Query: 488 MESTGPAGHCPH--LVESVPCEDPMC---YRWLASEGICFPDHGKCGLGHRILKAVC--- 539
S+ P C + E+ PC++ C W A G +CG G + + +C
Sbjct: 827 --SSLPLEGCGNNRPAEATPCDNGPCTGKVEWFA--GSWSQCSIECGSGTQQREVICVRK 882
Query: 540 QNDRGEDVSGSLCP-VPPPPERKSCEI-PCRMDCVLSEW--TEWSSCSQSCSNKNSDGKQ 595
D E + S C + PP ++SC + PC ++W TEWS CS+SC G +
Sbjct: 883 NADTFEVLDPSECSFLEKPPSQQSCHLKPCG-----AKWFSTEWSMCSKSCQG----GFR 933
Query: 596 TRSRTILALAGEGGKPCPPSQALQEHRLCNDHSCM 630
R L+ C P +E CN C+
Sbjct: 934 VREVRCLSDDMTLSNLCDPQLKPEERESCNPQDCV 968
Score = 51.6 bits (122), Expect = 6e-06
Identities = 86/358 (24%), Positives = 131/358 (36%), Gaps = 94/358 (26%)
Query: 16 GPWGRCTGDCGPGGVQSRAVWCFHV---DGWTSHLSNCGESNRPPKERSC-FRVCDWHSD 71
G W C+ CG G+Q R V C V T C +P +C ++C
Sbjct: 683 GEWSECSKTCGL-GMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICS---- 737
Query: 72 LFQWEV-SDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEH 130
+W++ +DW C V G + R V+C+ + VV +E C +
Sbjct: 738 --EWQIRTDWTSC----------------SVPCGVGQRTRDVKCVSNIG-DVVDDEEC-N 777
Query: 131 FALQPPTEQAC-LIPCPRDCVVSEFLPWS-NCSKGCGKKLQHR-----TRAVIAPPLFGG 183
L+P + C + PC + ++E WS CS CG ++ R T V + PL G
Sbjct: 778 MKLRPNDIENCDMGPCAKSWFLTE---WSERCSAECGAGVRTRSVVCMTNHVSSLPLEG- 833
Query: 184 LQCPNLTESRACDAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDSN 243
C N + A G+ E+ G WS+C
Sbjct: 834 --CGNNRPAEATPCDNGPCTGKVEWF----AGSWSQC----------------------- 864
Query: 244 ERVTFKHQSYKAHHHSKSWAIEIGYQTRQVSCTRSDGQNAML---SLCLQDSFPLTVQSC 300
S G Q R+V C R + + S C P + QSC
Sbjct: 865 -----------------SIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSC 907
Query: 301 IMPKDCETSQWSS-WSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEAC 357
+ K C +S+ WS CSK+C+ G + R S ++ + + PE E+E+C
Sbjct: 908 HL-KPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPE--ERESC 962
Score = 50.8 bits (120), Expect = 1e-05
Identities = 82/323 (25%), Positives = 121/323 (37%), Gaps = 64/323 (19%)
Query: 266 IGYQTRQVSCTRSDGQNAMLSL----CLQDSFPLTVQSCIMPKDCETSQWSSWSPCSKTC 321
+G Q RQV C R N L++ C P T +C + E + W+ CS C
Sbjct: 694 LGMQHRQVLC-RQVYANRSLTVQPYRCQHLEKPETTSTCQLKICSEWQIRTDWTSCSVPC 752
Query: 322 RSGSLLPGFRSRSRNVKHMAIGGG----KECPELLEKEACIVEGELLQQCPRYSWRTSEW 377
G R+R+VK ++ G +EC L +E + C + SW +EW
Sbjct: 753 -------GVGQRTRDVKCVSNIGDVVDDEECNMKLRPND--IENCDMGPCAK-SWFLTEW 802
Query: 378 KE-CQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKALCV 436
E C CG G++TR V C + ++ L +RP E C
Sbjct: 803 SERCSAE----------------CGAGVRTRSVVCMTNHVSSLPLEGCGNNRPAEATPC- 845
Query: 437 GPAPLPSQLCNIPCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGH 496
N PC T + +W C E Q ++ R+ E P+
Sbjct: 846 ---------DNGPC-TGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPS-E 894
Query: 497 CPHLVESVPCED-----PMCYRWLASE-GICFPDHGKCGLGHRILKAVCQNDRGEDVSGS 550
C L E P + P +W ++E +C C G R+ + C +D + +
Sbjct: 895 CSFL-EKPPSQQSCHLKPCGAKWFSTEWSMC---SKSCQGGFRVREVRCLSD--DMTLSN 948
Query: 551 LC-PVPPPPERKSCEIPCRMDCV 572
LC P P ER+SC DCV
Sbjct: 949 LCDPQLKPEERESCN---PQDCV 968
Score = 44.7 bits (104), Expect = 7e-04
Identities = 39/142 (27%), Positives = 63/142 (44%), Gaps = 28/142 (19%)
Query: 1228 TECSQTCGHGGRMSRTRFIIMPTQGEGRP--CPTEL---TQEKTCPVTPCYS-WVLGNWS 1281
TECS TCG G + R + T E C + + +E+ C + PC + W +G WS
Sbjct: 627 TECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAFWDIGEWS 686
Query: 1282 ACKLEGGDCGEGVQIRSLSC--MVHSGSISHAAGRVEDALCGEMPFQDSILK-QLCSVPC 1338
C CG G+Q R + C + + S++ R + E P S + ++CS
Sbjct: 687 EC---SKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHL---EKPETTSTCQLKICS--- 737
Query: 1339 PGDCHLTEW---SEWSTCELTC 1357
EW ++W++C + C
Sbjct: 738 -------EWQIRTDWTSCSVPC 752
Score = 44.7 bits (104), Expect = 7e-04
Identities = 37/140 (26%), Positives = 60/140 (42%), Gaps = 33/140 (23%)
Query: 15 AGPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHL---SNCGESNRPPKERSC-FRVCDWHS 70
AG W +C+ +CG G Q R V C + T + S C +PP ++SC + C
Sbjct: 858 AGSWSQCSIECG-SGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCG--- 913
Query: 71 DLFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEH 130
+W ++W C + Q G + R VRC L+ + + +C+
Sbjct: 914 --AKWFSTEWSMC----------------SKSCQGGFRVREVRC---LSDDMTLSNLCDP 952
Query: 131 FALQPPTEQACLIPCPRDCV 150
L+P ++C P+DCV
Sbjct: 953 -QLKPEERESC---NPQDCV 968
Score = 33.5 bits (75), Expect = 1.7
Identities = 28/98 (28%), Positives = 41/98 (41%), Gaps = 20/98 (20%)
Query: 551 LCPVPPPPERKSCEIPCRMDC--------------VLSEWTEWSSCSQSCSNKNSDGKQT 596
+CP P RK +P RM V W WS+CS+SCS + QT
Sbjct: 23 VCPQPSTQHRK---VPQRMAAEGAPEDDGGGGAPGVWGAWGPWSACSRSCSGGVME--QT 77
Query: 597 RSRTILALAGEGG-KPCPPSQALQEHRLCNDHSCMQLH 633
R + GG +P P++A +H + + + LH
Sbjct: 78 RPCLPRSYRLRGGQRPGAPARAFADHVVSAVRTSVPLH 115
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 92.8 bits (229), Expect = 2e-18
Identities = 131/575 (22%), Positives = 200/575 (34%), Gaps = 148/575 (25%)
Query: 509 PMCYRWLASEGICFPDHGKCGLGHRILKAVCQNDRGEDV-SGSLCP-----VPPPPERKS 562
P+ +RW ++ FP CG G+++ A C + R V + C + P P+ +
Sbjct: 296 PIIHRWRETD--FFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQE 353
Query: 563 CEI-------------PCRMDCVLSEW--TEWSSCSQSCSNKNSDGKQTRSRTILALAGE 607
C + P + L W T W++CS SC G Q+R+ + + +
Sbjct: 354 CNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGG----GIQSRAVSCVEEDIQ 409
Query: 608 GGKP------CPPSQALQEHRLCNDHSCMQLHWETSPWGPCSEDTLVTALNATIGWNGEA 661
G C + + + CN C + W W PC+
Sbjct: 410 GHVTSVEEWKCMYTPKMPIAQPCNIFDCPK--WLAQEWSPCT-----------------V 450
Query: 662 TCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPETVRPCFLPC-----KKDCIVTAFSEWT 716
TCG G++ R V C+ H G + T C T+P C +P K+ V A W
Sbjct: 451 TCGQGLRYRVVLCI-DHRG-MHTGGCSPKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWF 508
Query: 717 PCPRMCQAGNATVKQSRYRIIIQEAAN--------GGQ----ECPDTLYEERECEDVSLC 764
+ + G A ++ + I EA + G Q C L + D+ +
Sbjct: 509 KQAQELEEGAAVSEEPSF---IPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPID 565
Query: 765 PVYRWKPQKWSPCILVPES---------------------------VWQGITGSSEACGK 797
KP C P S ++G T SE+CG
Sbjct: 566 ECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGG 625
Query: 798 GLQTRAVSCISDDNRSAEMMECLKQTNGMPLLVQECTV-PCREDCTFTAWSKFTPCSTNC 856
G+Q VSC++ R + P L++ C + PC WS PCS C
Sbjct: 626 GVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARWEIGKWS---PCSLTC 682
Query: 857 EATKSRRRQLTGKSRKKEKCQDSDLYPLVETELC---------PCDEFISQPY---GNWS 904
R +E + ++ ELC C+ F P W
Sbjct: 683 GVGLQTRDVFCSHLLSREMNET----VILADELCRQPKPSTVQACNRFNCPPAWYPAQWQ 738
Query: 905 DCILPEGRREPHRGLRVQADSKECGEGLRFRAVAC----SDKNGRPVDPSFCSSSGYIQE 960
C S+ CG G++ R V C +D + + +FCS+S +
Sbjct: 739 PC------------------SRTCGGGVQKREVLCKQRMADGSFLELPETFCSAS---KP 777
Query: 961 KCVIPCPFDCKLSDW--SSWGSCSSSCGIGVRIRS 993
C C D S+W S W CS+SCG G + RS
Sbjct: 778 ACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRS 812
Score = 91.7 bits (226), Expect = 5e-18
Identities = 133/580 (22%), Positives = 198/580 (34%), Gaps = 178/580 (30%)
Query: 766 VYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCIS-DDNRSAEMMECLKQTN 824
++RW+ + PC S CG G Q + C NR C
Sbjct: 298 IHRWRETDFFPC--------------SATCGGGYQLTSAECYDLRSNRVVADQYCHYYPE 343
Query: 825 GM---PLLVQECTV-PCREDCTFTA------------W--SKFTPCSTNC------EATK 860
+ P L QEC + PC + W + +T CS++C A
Sbjct: 344 NIKPKPKL-QECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVS 402
Query: 861 SRRRQLTGKSRKKE--KCQDSDLYPLVET-ELCPCDEFISQPYGNWSDCILPEGRREPHR 917
+ G E KC + P+ + + C ++++Q WS C +
Sbjct: 403 CVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPKWLAQ---EWSPCTVT-------- 451
Query: 918 GLRVQADSKECGEGLRFRAVACSDKNGRPVDPSFCSSSGYIQEKCVIPCP---------F 968
CG+GLR+R V C D G + +I+E+C++P P
Sbjct: 452 ----------CGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECIVPTPCYKPKEKLPV 501
Query: 969 DCKLSDW---------------------SSWGSCSSSCGIGVRIR----------SKWLK 997
+ KL W +W +C+ +CG+G ++R S+ +
Sbjct: 502 EAKLP-WFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVA 560
Query: 998 EKPYN---GGRPCPKLDLKNQAQVHEAVPCYSECNQ-------------------YSWVV 1035
+ P + G +P + + A PC E + Y W
Sbjct: 561 DLPIDECEGPKPASQ-------RACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEY 613
Query: 1036 EHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPET-QSCSL- 1093
E ++ C S CGGG Q + C+N E + NLC PP+ +SC+L
Sbjct: 614 EGFTKC-------SESCGGGVQEAVVSCLNKQTRE--PAEENLCVTSRRPPQLLKSCNLD 664
Query: 1094 MCPNECVMSEWGLWSKCPQSCDPHTMQRRT--RHLLRPSLNSRTCAED--------SQVQ 1143
CP E G WS C +C R HLL +N D S VQ
Sbjct: 665 PCPARW---EIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQ 721
Query: 1144 PCLLNENCFQFQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHNLEK 1203
C NC Y +W C + CG GV+ R + C + LE
Sbjct: 722 ACN-RFNCPPAWYP-AQWQPCSRT----CGGGVQKREVLC--------KQRMADGSFLEL 767
Query: 1204 PQRMSIPCLVECVVNCQL----SGW--TAWTECSQTCGHG 1237
P+ C C+ S W + WTECS +CG G
Sbjct: 768 PETFCSASKPACQQACKKDDCPSEWLLSDWTECSTSCGEG 807
Score = 75.1 bits (183), Expect = 5e-13
Identities = 116/499 (23%), Positives = 174/499 (34%), Gaps = 121/499 (24%)
Query: 10 LYHKL----AGPWGRCTGDCGPGGVQSRAVWCFHVD--GWTSHLS--NCGESNRPPKERS 61
LYH L A PW C+ CG GG+QSRAV C D G + + C + + P +
Sbjct: 373 LYHPLPRWEATPWTACSSSCG-GGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQP 431
Query: 62 CFRVCDWHSDLFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRT 121
C D +W +W C VT GL++R+V CI
Sbjct: 432 CNIF-----DCPKWLAQEWSPCT----------------VTCGQGLRYRVVLCIDHRGMH 470
Query: 122 VVANEICEHFALQPPTEQACLIPCP------------------------RDCVVSE---F 154
C +P ++ C++P P VSE F
Sbjct: 471 TGG---CSP-KTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSF 526
Query: 155 LP--WSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPNLT--ESRACDAPI-SCPLGEEEYT 209
+P WS C+ CG Q R ++C L D PI C +
Sbjct: 527 IPEAWSACTVTCGVGTQVRI-----------VRCQVLLSFSQSVADLPIDECEGPKPASQ 575
Query: 210 FSLKVGPWSKCRLPHLKEINPSGRTVLDFN-SDSNERVTFKHQSYKAHHHSKSWAIEIGY 268
+ GP S + E NP L D +E ++++ + S G
Sbjct: 576 RACYAGPCS----GEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGG----GV 627
Query: 269 QTRQVSC-TRSDGQNAMLSLCLQDSF-PLTVQSCIMPKDCETSQWSSWSPCSKTCRSGSL 326
Q VSC + + A +LC+ P ++SC + + WSPCS TC
Sbjct: 628 QEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCG---- 683
Query: 327 LPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEGELLQQCPRY----SWRTSEWKECQV 382
G ++R H+ E L ++ + +Q C R+ +W ++W+ C
Sbjct: 684 -VGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPPAWYPAQWQPC-- 740
Query: 383 SLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKALCVGPAPLP 442
CGGG+Q REV C Q + + L E C P
Sbjct: 741 --------------SRTCGGGVQKREVLCKQRMADGSFLELPE-------TFCSASKPAC 779
Query: 443 SQLC-NIPCSTDCIVSSWS 460
Q C C ++ ++S W+
Sbjct: 780 QQACKKDDCPSEWLLSDWT 798
Score = 74.7 bits (182), Expect = 7e-13
Identities = 199/897 (22%), Positives = 300/897 (33%), Gaps = 227/897 (25%)
Query: 16 GPWGRCTGDCGPGGVQS--RAVWCFHVDGWTSHLSNCGESNRPPKERSCFRV--CDWHSD 71
GPW C+ CG G S R + +G C + PP E FR C H+D
Sbjct: 40 GPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPP-EAGDFRAQQCSAHND 98
Query: 72 L-FQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEH 130
+ + +W +P + P + +C Q + + +L V+ C
Sbjct: 99 VKHHGQFYEW-----LPVSNDPDNPCSLKC-------QAKGTTLVVELAPKVLDGTRCYT 146
Query: 131 FALQPPTEQAC-LIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPNL 189
+L C ++ C D + + NC G R L G L
Sbjct: 147 ESLDMCISGLCQIVGC--DHQLGSTVKEDNCGVCNGDGSTCR--------LVRGQYKSQL 196
Query: 190 TESRACDAPISCPLGEEEYTFSLKVGPWSKCRLPHLK------EINPSGRTVLDFNSDSN 243
+ +++ D ++ P G LK L+ ++ +G ++D +S
Sbjct: 197 SATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDF 256
Query: 244 ERVTFKHQSYKAHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMP 303
++ K A + + ++I R+ G S TVQ
Sbjct: 257 QKFPDKEILRMAGPLTADFIVKI----------RNSG-----------SADSTVQFIFYQ 295
Query: 304 KDCETSQWSSWSPCSKTCRSGSLLPG---FRSRSRNVK-----HMAIGGGKECPELLE-- 353
+ + + PCS TC G L + RS V H K P+L E
Sbjct: 296 PIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECN 355
Query: 354 KEAC--------IVEGELLQQCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQ 405
+ C I+ +L PR W + W C S CGGGIQ
Sbjct: 356 LDPCPASDGYKQIMPYDLYHPLPR--WEATPWTACSSS----------------CGGGIQ 397
Query: 406 TREVYCAQSVPAAAALRAKEVSRPVEKALCVGPAPLP-SQLCNI------------PCST 452
+R V C + ++ S VE+ C+ +P +Q CNI PC+
Sbjct: 398 SRAVSCVEE-----DIQGHVTS--VEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTV 450
Query: 453 DCIVSSWSAWGLCI-HENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVESVPCEDPMC 511
C LCI H H G +T+ H+ E P C E +P E +
Sbjct: 451 TCGQGLRYRVVLCIDHRGMHT--GGCSPKTKP-HIKEECIVPTP-CYKPKEKLPVEAKLP 506
Query: 512 YRWLASE---GICFPDHGK------------CGLGHRILKAVCQ-----NDRGEDVSGSL 551
+ A E G + CG+G ++ CQ + D+
Sbjct: 507 WFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDE 566
Query: 552 CPVPPPPERKSCEI-PCRMDCV----------------LSEWTEW-----SSCSQSCSNK 589
C P P +++C PC + E +W + CS+SC
Sbjct: 567 CEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGG 626
Query: 590 NSDG------KQTRSRTILALAGEGGKPCPPSQALQEHRLCNDHSCMQLHWETSPWGPCS 643
+ KQTR L +P Q L+ CN C WE W PCS
Sbjct: 627 VQEAVVSCLNKQTREPAEENLCVTSRRP---PQLLKS---CNLDPC-PARWEIGKWSPCS 679
Query: 644 EDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHV-------GQVMTKRCPDSTRPETV 696
TCGVG+QTR VFC SH+ ++ +P TV
Sbjct: 680 -----------------LTCGVGLQTRDVFC--SHLLSREMNETVILADELCRQPKPSTV 720
Query: 697 RPCFLPCKKDCIVTAF-SEWTPCPRMCQAGNATVKQSRYRIIIQEAANGG-QECPDTLYE 754
+ C + +C + ++W PC R C G Q R + Q A+G E P+T
Sbjct: 721 QAC---NRFNCPPAWYPAQWQPCSRTCGGG----VQKREVLCKQRMADGSFLELPETFCS 773
Query: 755 ERE--CEDVSL---CPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSC 806
+ C+ CP W W+ C S +CG+G QTR+ C
Sbjct: 774 ASKPACQQACKKDDCP-SEWLLSDWTEC--------------STSCGEGTQTRSAIC 815
Score = 66.6 bits (161), Expect = 2e-10
Identities = 116/539 (21%), Positives = 180/539 (33%), Gaps = 137/539 (25%)
Query: 1006 PCPKLDLKNQAQVHEAVPCYSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVN 1065
PCP D Q ++ W W++C S CGGG QSR + CV
Sbjct: 358 PCPASDGYKQIMPYDLYHPLPR-----WEATPWTAC-------SSSCGGGIQSRAVSCVE 405
Query: 1066 T-ADGEGGAVDSNLCNQDEIPPETQSCSLM-CPNECVMSEWGLWSKCPQSCDPHTMQRRT 1123
G +V+ C P Q C++ CP WS C +C R
Sbjct: 406 EDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPKWLAQE----WSPCTVTCGQGLRYRVV 461
Query: 1124 RHLLRPSLNSRTCAEDSQV---QPCLLNENCFQFQYNLT--------------------- 1159
+ +++ C+ ++ + C++ C++ + L
Sbjct: 462 LCIDHRGMHTGGCSPKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVS 521
Query: 1160 --------EWSTCQLSENAPCGQGVRTRLLSCV----------------CSDGKPVSMDQ 1195
WS C ++ CG G + R++ C C KP S
Sbjct: 522 EEPSFIPEAWSACTVT----CGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRA 577
Query: 1196 CEQHNLEKPQRMSIPCLVECVVNCQLSG-----------WTAWTECSQTCGHGGRMSRTR 1244
C P IP + G + +T+CS++CG G + +
Sbjct: 578 C----YAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVS 633
Query: 1245 FIIMPTQ--GEGRPCPTELTQE---KTCPVTPCYS-WVLGNWSACKLEGGDCGEGVQIRS 1298
+ T+ E C T K+C + PC + W +G WS C L CG G+Q R
Sbjct: 634 CLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSL---TCGVGLQTRD 690
Query: 1299 LSCMVHSGSISHAAGRVEDALCGEMPFQDSILKQLCSVPCPGDCHLTE-------W--SE 1349
+ C SH R EM + +LC P P W ++
Sbjct: 691 VFC-------SHLLSR-------EMNETVILADELCRQPKPSTVQACNRFNCPPAWYPAQ 736
Query: 1350 WSTCELTCIDG-RSFETVGRQSRSRTFIIQSFENQDSCPQQVLETRPCTGGKCYHYTWKA 1408
W C TC G + E + +Q + ++ E S + + + C C W
Sbjct: 737 WQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQ-QACKKDDC-PSEWLL 794
Query: 1409 SLW---------NNNERTVWCQR------SDGVNVTGGCSPQARPAAIRQCIPA-CRKP 1451
S W R+ C++ S VN T C P ++IR C+ A C +P
Sbjct: 795 SDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNST-LCPPLPFSSSIRPCMLATCARP 852
Score = 60.1 bits (144), Expect = 2e-08
Identities = 116/493 (23%), Positives = 162/493 (32%), Gaps = 145/493 (29%)
Query: 14 LAGPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFRVCDWHSDL- 72
LA W CT CG G ++ R V C +D H C +P + C +
Sbjct: 441 LAQEWSPCTVTCGQG-LRYRVVLC--IDHRGMHTGGCSPKTKPHIKEECIVPTPCYKPKE 497
Query: 73 -------FQW--EVSDWHHCVLVPYARGEVKPRTAEC-VTAQHGLQHRMVRC--IQKLNR 120
W + + V + + C VT G Q R+VRC + ++
Sbjct: 498 KLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQ 557
Query: 121 TVVANEICEHFALQPPTEQACLI-PCPRDCVVSEFLP----------------------- 156
+V I E +P +++AC PC + + EF P
Sbjct: 558 SVADLPIDECEGPKPASQRACYAGPCSGE--IPEFNPDETDGLFGGLQDFDELYDWEYEG 615
Query: 157 WSNCSKGCGKKLQH--------RTRAVIAPPL-FGGLQCPNLTESRACDAPISCPLGEEE 207
++ CS+ CG +Q +TR L + P L +S D CP E
Sbjct: 616 FTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDP---CPARWE- 671
Query: 208 YTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDSNERVTFKHQSYKAHHHSKSWAIEIG 267
+G WS C L +G
Sbjct: 672 ------IGKWSPCSL----------------------------------------TCGVG 685
Query: 268 YQTRQVSCT----RSDGQNAMLS--LCLQDSFPLTVQSCIMPKDCETSQW-SSWSPCSKT 320
QTR V C+ R + +L+ LC Q P TVQ+C +C + + + W PCS+T
Sbjct: 686 LQTRDVFCSHLLSREMNETVILADELCRQPK-PSTVQACNR-FNCPPAWYPAQWQPCSRT 743
Query: 321 CRSGSLLPGFRSRSRNVKHMAIGGGKECPELL---EKEACIVEGELLQQCPRYSWRTSEW 377
C G + R MA G E PE K AC + CP W S+W
Sbjct: 744 CGGGVQKREVLCKQR----MADGSFLELPETFCSASKPAC-QQACKKDDCPS-EWLLSDW 797
Query: 378 KECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKALCVG 437
EC S CG G QTR C + + +S V LC
Sbjct: 798 TECSTS----------------CGEGTQTRSAICRKMLKTG-------LSTVVNSTLC-- 832
Query: 438 PAPLPSQLCNIPC 450
PLP PC
Sbjct: 833 -PPLPFSSSIRPC 844
Score = 59.7 bits (143), Expect = 2e-08
Identities = 110/493 (22%), Positives = 165/493 (33%), Gaps = 99/493 (20%)
Query: 267 GYQTRQVSCTRSDGQNAMLSL----CLQDSFPLTVQSCIMPKDCETSQWSSWSPCSKTCR 322
G Q+R VSC D Q + S+ C+ Q C + DC WSPC+ TC
Sbjct: 395 GIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNI-FDCPKWLAQEWSPCTVTCG 453
Query: 323 SGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEG------ELLQQCPRYSWRTSE 376
G H K P + KE CIV E L + W +
Sbjct: 454 QGLRYRVVLCIDHRGMHTGGCSPKTKPHI--KEECIVPTPCYKPKEKLPVEAKLPW-FKQ 510
Query: 377 WKECQVSLLLEQQDPH----WHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEK 432
+E + + ++ W CG G Q R V C + + ++ P+++
Sbjct: 511 AQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSV----ADLPIDE 566
Query: 433 ALCVGPAPLPSQLCNI-PCS----------TDCIVSS---------WSAWGLC------- 465
C GP P + C PCS TD + W G
Sbjct: 567 --CEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCG 624
Query: 466 --IHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVESVPCEDPMCYRWLASEGICFP 523
+ E K+ + ++ + S P P L++S DP RW G P
Sbjct: 625 GGVQEAVVSCLNKQTREPAEENLCVTSRRP----PQLLKSCNL-DPCPARW--EIGKWSP 677
Query: 524 DHGKCGLGHRILKAVCQN----DRGEDV--SGSLCPVPPPPERKSCEIPCRMDCVLSEW- 576
CG+G + C + + E V + LC P P ++C R +C + +
Sbjct: 678 CSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACN---RFNCPPAWYP 734
Query: 577 TEWSSCSQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHRLCNDHSCMQ----L 632
+W CS++C G Q R +G P + +C +
Sbjct: 735 AQWQPCSRTCGG----GVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDDCPS 790
Query: 633 HWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFC---VKSHVGQVMTKR-CP 688
W S W CS +CG G QTR C +K+ + V+ CP
Sbjct: 791 EWLLSDWTECS-----------------TSCGEGTQTRSAICRKMLKTGLSTVVNSTLCP 833
Query: 689 DSTRPETVRPCFL 701
++RPC L
Sbjct: 834 PLPFSSSIRPCML 846
Score = 54.3 bits (129), Expect = 9e-07
Identities = 51/170 (30%), Positives = 64/170 (37%), Gaps = 44/170 (25%)
Query: 18 WGRCTGDC-GPG-GVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCF-RVCDWHSDLFQ 74
WG+C G C GP VQ R V+C DG T C RP ++C+ C H
Sbjct: 1615 WGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACSVH----- 1669
Query: 75 WEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHFALQ 134
W VS W C TA C +G Q R V C+ V +C + +
Sbjct: 1670 WRVSLWTLC-------------TATC--GNYGFQSRRVECVHARTNKAVPEHLCS-WGPR 1713
Query: 135 PPTEQAC-LIPCP----RD-------------CVVSEFLPWSNCSKGCGK 166
P Q C + PC RD C +S+F S C CGK
Sbjct: 1714 PANWQRCNITPCENMECRDTTRYCEKVKQLKLCQLSQFK--SRCCGTCGK 1761
Score = 52.8 bits (125), Expect = 3e-06
Identities = 72/307 (23%), Positives = 108/307 (35%), Gaps = 58/307 (18%)
Query: 580 SSCSQSCSNKNSDGKQTR---SRTILALAGEGGKPCPPSQALQEHRLCNDHSCMQLHWET 636
++CS SC N+ + R + T + A GK P Q + CN C W
Sbjct: 1497 ATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIA----CNRRDCPS-RWMV 1551
Query: 637 SPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPETV 696
+ W C+ +CG G+QTRRV C K + T D
Sbjct: 1552 TSWSACTR-----------------SCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAK 1594
Query: 697 RPC-FLPCKKD-CIVTAFSEWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQECPDTLYE 754
RP C + C+ AFS W C C + V+ + ++ E L
Sbjct: 1595 RPVDTQACNQQLCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPR 1654
Query: 755 ERECEDV--SLCPVYRWKPQKWSPCILVPESVWQGITGSSEACGK-GLQTRAVSCISDDN 811
++ C V+ W+ W+ C + CG G Q+R V C+
Sbjct: 1655 PVSTQNCWSEACSVH-WRVSLWTLC--------------TATCGNYGFQSRRVECVHART 1699
Query: 812 RSAEMMECLKQTNGMPLLVQECTV-PCRE-DCTFTAWSKFTPCSTNCEATKSRRRQLTGK 869
A + E L P Q C + PC +C T + CE K ++ +L
Sbjct: 1700 NKA-VPEHLCSWGPRPANWQRCNITPCENMECRDT--------TRYCE--KVKQLKLCQL 1748
Query: 870 SRKKEKC 876
S+ K +C
Sbjct: 1749 SQFKSRC 1755
Score = 51.6 bits (122), Expect = 6e-06
Identities = 60/221 (27%), Positives = 85/221 (38%), Gaps = 47/221 (21%)
Query: 365 QQCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAK 424
+ CP W + W C S CGGG+QTR V C + L+A
Sbjct: 1543 RDCPS-RWMVTSWSACTRS----------------CGGGVQTRRVTCQK-------LKAS 1578
Query: 425 EVSRPVEKALC--VGPAPLPSQLCNIPCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTR 482
+S PV +C V P+ +Q CN C+ ++S+WG C + C P +
Sbjct: 1579 GISTPVSNDMCTQVAKRPVDTQACN---QQLCVEWAFSSWGQC-NGPCIGPH----LAVQ 1630
Query: 483 QRHVLMES----TGPAGHC---PHLVESVPCEDPMC-YRWLAS-EGICFPDHGKCGLGHR 533
R V ++ T P+ C P V + C C W S +C G G R
Sbjct: 1631 HRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACSVHWRVSLWTLCTATCGNYGFQSR 1690
Query: 534 ILKAVCQNDRGEDVSGSLCPVPPPPER-KSCEI-PC-RMDC 571
++ V + V LC P P + C I PC M+C
Sbjct: 1691 RVECV-HARTNKAVPEHLCSWGPRPANWQRCNITPCENMEC 1730
Score = 50.4 bits (119), Expect = 1e-05
Identities = 69/268 (25%), Positives = 103/268 (38%), Gaps = 57/268 (21%)
Query: 1031 YSWVVEHWSSCKINNELRSLRCGG-GTQSRKIRC------VNTADGEGG---AVDSNLCN 1080
Y W V+ ++C S CG G Q ++RC VN A G AV CN
Sbjct: 1489 YWWSVDRLATC-------SASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACN 1541
Query: 1081 QDEIPPETQSCSLMCPNECVMSEWGLWSKCPQSCDPHTMQRR-TRHLLRPSLNSRTCAED 1139
+ + CP+ +++ W S C +SC RR T L+ S S + D
Sbjct: 1542 RRD-----------CPSRWMVTSW---SACTRSCGGGVQTRRVTCQKLKASGISTPVSND 1587
Query: 1140 SQVQPC---LLNENCFQ---FQYNLTEWSTCQLSENAPC---GQGVRTRLLSCVCSDGKP 1190
Q + + C Q ++ + W C N PC V+ R + C DG
Sbjct: 1588 MCTQVAKRPVDTQACNQQLCVEWAFSSWGQC----NGPCIGPHLAVQHRQVFCQTRDGIT 1643
Query: 1191 VSMDQCEQHNLEKPQRMSIPCLVECVVNCQLSGWTAWTECSQTCGHGGRMSRTRFIIMPT 1250
+ +QC L +P C V+ ++S WT C+ TCG+ G SR +
Sbjct: 1644 LPSEQCSA--LPRPVSTQNCWSEACSVHWRVS---LWTLCTATCGNYGFQSRRVECVHAR 1698
Query: 1251 QGEGRP---C---PTELTQEKTCPVTPC 1272
+ P C P ++ C +TPC
Sbjct: 1699 TNKAVPEHLCSWGPRPANWQR-CNITPC 1725
Score = 48.5 bits (114), Expect = 5e-05
Identities = 56/219 (25%), Positives = 81/219 (36%), Gaps = 50/219 (22%)
Query: 568 RMDCVLSEW--TEWSSCSQSCSNKNSDGKQTRSRTILALAGEG-GKPCPPSQALQ----- 619
R DC S W T WS+C++SC G QTR T L G P Q
Sbjct: 1542 RRDCP-SRWMVTSWSACTRSCGG----GVQTRRVTCQKLKASGISTPVSNDMCTQVAKRP 1596
Query: 620 -EHRLCNDHSCMQLHWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSH 678
+ + CN C++ W S WG C+ + L +Q R+VFC
Sbjct: 1597 VDTQACNQQLCVE--WAFSSWGQCNGPCIGPHL--------------AVQHRQVFCQTRD 1640
Query: 679 VGQVMTKRCPDSTRPETVRPCFLPCKKDCIV-TAFSEWTPCPRMCQAGNATVKQSRY--- 734
+ +++C RP + + C+ + C V S WT C C GN + R
Sbjct: 1641 GITLPSEQCSALPRPVSTQNCW---SEACSVHWRVSLWTLCTATC--GNYGFQSRRVECV 1695
Query: 735 -----RIIIQEAANGG------QECPDTLYEERECEDVS 762
+ + + + G Q C T E EC D +
Sbjct: 1696 HARTNKAVPEHLCSWGPRPANWQRCNITPCENMECRDTT 1734
Score = 43.5 bits (101), Expect = 0.002
Identities = 53/206 (25%), Positives = 79/206 (38%), Gaps = 32/206 (15%)
Query: 21 CTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFRVCDWHSDLFQWEVSDW 80
C+ CG GVQ + C ++ + ++C RP + C+ +W V+ W
Sbjct: 1499 CSASCGNRGVQQPRLRCL-LNSTEVNPAHCAGKVRPAVQPIA---CNRRDCPSRWMVTSW 1554
Query: 81 HHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNR----TVVANEICEHFALQPP 136
C T C G+Q R V C QKL T V+N++C A +P
Sbjct: 1555 SAC-------------TRSC---GGGVQTRRVTC-QKLKASGISTPVSNDMCTQVAKRPV 1597
Query: 137 TEQACLIPCPRDCVVSEFLPWSNCSKGC-GKKLQHRTRAVIAPPLFGGLQCPNLTESRAC 195
QAC + CV F W C+ C G L + R V G+ P+ + A
Sbjct: 1598 DTQAC---NQQLCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTR-DGITLPS-EQCSAL 1652
Query: 196 DAPISCP-LGEEEYTFSLKVGPWSKC 220
P+S E + +V W+ C
Sbjct: 1653 PRPVSTQNCWSEACSVHWRVSLWTLC 1678
Score = 43.1 bits (100), Expect = 0.002
Identities = 55/214 (25%), Positives = 82/214 (38%), Gaps = 29/214 (13%)
Query: 920 RVQADSKECGE-GLRFRAVACSDKNGRPVDPSFCSSSGYIQEKCVIPCPFDCKLSDW--S 976
R+ S CG G++ + C N V+P+ C+ + + DC S W +
Sbjct: 1495 RLATCSASCGNRGVQQPRLRCL-LNSTEVNPAHCAGKVRPAVQPIACNRRDCP-SRWMVT 1552
Query: 977 SWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHEAVPCYSECNQ---YSW 1033
SW +C+ SCG GV+ R ++ +G D+ QV + CNQ W
Sbjct: 1553 SWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDM--CTQVAKRPVDTQACNQQLCVEW 1610
Query: 1034 VVEHWSSCK---INNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQS 1090
W C I L Q R++ C T DG + S C+ P TQ+
Sbjct: 1611 AFSSWGQCNGPCIGPHL-------AVQHRQVFC-QTRDGI--TLPSEQCSALPRPVSTQN 1660
Query: 1091 CSLMCPNECVMSEW--GLWSKCPQSCDPHTMQRR 1122
C +E W LW+ C +C + Q R
Sbjct: 1661 CW----SEACSVHWRVSLWTLCTATCGNYGFQSR 1690
Score = 42.4 bits (98), Expect = 0.004
Identities = 41/154 (26%), Positives = 60/154 (38%), Gaps = 30/154 (19%)
Query: 18 WGRCTGDCGPGGVQSRAVWC--FHVDGWTSHLSN--CGE-SNRPPKERSC-FRVCDWHSD 71
W CT CG GGVQ+R V C G ++ +SN C + + RP ++C ++C
Sbjct: 1554 WSACTRSCG-GGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC----- 1607
Query: 72 LFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHF 131
+W S W C C+ +QHR V C Q + + +E C
Sbjct: 1608 -VEWAFSSWGQC-------------NGPCIGPHLAVQHRQVFC-QTRDGITLPSEQCSAL 1652
Query: 132 ALQPPTEQACLIPCPRDCVVSEFLPWSNCSKGCG 165
T+ C VS W+ C+ CG
Sbjct: 1653 PRPVSTQNCWSEACSVHWRVS---LWTLCTATCG 1683
Score = 40.0 bits (92), Expect = 0.018
Identities = 48/214 (22%), Positives = 79/214 (36%), Gaps = 39/214 (18%)
Query: 1161 WSTCQLSE-NAPCG-QGVRTRLLSCVCSDGKPVSMDQCEQHNLEKPQRMSIPCLVECVVN 1218
WS +L+ +A CG +GV+ L C+ + + V+ C +P I C +
Sbjct: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTE-VNPAHCA--GKVRPAVQPIACNRR---D 1544
Query: 1219 CQLSGW--TAWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPTELTQE--------KTCP 1268
C S W T+W+ C+++CG G + R + G P ++ + + C
Sbjct: 1545 CP-SRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACN 1603
Query: 1269 VTPCYSWVLGNWSACKLEGGDC---GEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPF 1325
C W +W C G C VQ R + C G + C +P
Sbjct: 1604 QQLCVEWAFSSWGQC---NGPCIGPHLAVQHRQVFCQTRDGI------TLPSEQCSALP- 1653
Query: 1326 QDSILKQLCSVPCPGDCHLTEW--SEWSTCELTC 1357
+ + + C + W S W+ C TC
Sbjct: 1654 -----RPVSTQNCWSEACSVHWRVSLWTLCTATC 1682
Score = 38.1 bits (87), Expect = 0.068
Identities = 23/88 (26%), Positives = 36/88 (40%), Gaps = 18/88 (20%)
Query: 570 DCVLSEWTEWSSCSQSC------------SNKNSDGKQTRSRTILALAGEGGKPCPPSQA 617
D + W WS CS++C S+K+ +G+ R RT CPP
Sbjct: 33 DGLWDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTC------SNVDCPPEAG 86
Query: 618 LQEHRLCNDHSCMQLHWETSPWGPCSED 645
+ C+ H+ ++ H + W P S D
Sbjct: 87 DFRAQQCSAHNDVKHHGQFYEWLPVSND 114
Score = 34.7 bits (78), Expect = 0.75
Identities = 25/98 (25%), Positives = 32/98 (32%), Gaps = 20/98 (20%)
Query: 3 NTADEVVLYHKLAGPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSC 62
N E H W CT CG G QSR V C H +N+ E
Sbjct: 1660 NCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVH-----------ARTNKAVPE--- 1705
Query: 63 FRVCDWHSDLFQWEVSDWHHCVLVPYARGEVKPRTAEC 100
+C W ++W C + P E + T C
Sbjct: 1706 -HLCSWGP-----RPANWQRCNITPCENMECRDTTRYC 1737
Score = 33.9 bits (76), Expect = 1.3
Identities = 47/197 (23%), Positives = 77/197 (39%), Gaps = 43/197 (21%)
Query: 304 KDCETSQW--SSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEG 361
+DC S+W +SWS C+++C G ++R V C +L K + I
Sbjct: 1543 RDCP-SRWMVTSWSACTRSCGGG-------VQTRRV---------TCQKL--KASGISTP 1583
Query: 362 ELLQQCPRYSWRTSEWKECQVSLLLEQQDPHW-HVTGPVCGG--GIQTREVYCAQSVPAA 418
C + + R + + C L +E W GP G +Q R+V+C
Sbjct: 1584 VSNDMCTQVAKRPVDTQACNQQLCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQ------ 1637
Query: 419 AALRAKEVSRPVEKALCVGPAPLPSQLC-NIPCSTDCIVSSWSAWGLCIHENCHDPQGKK 477
++ P E+ + P P+ +Q C + CS VS W+ C G
Sbjct: 1638 ---TRDGITLPSEQCSAL-PRPVSTQNCWSEACSVHWRVSLWTL--------CTATCGNY 1685
Query: 478 GFRTRQRHVLMESTGPA 494
GF++R+ + T A
Sbjct: 1686 GFQSRRVECVHARTNKA 1702
Score = 32.7 bits (73), Expect = 2.8
Identities = 19/60 (31%), Positives = 25/60 (41%), Gaps = 12/60 (20%)
Query: 1038 WSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPE-----TQSCS 1092
WS C S CGGG RC+++ EG + C+ + PPE Q CS
Sbjct: 42 WSEC-------SRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCS 94
Score = 32.3 bits (72), Expect = 3.7
Identities = 15/49 (30%), Positives = 21/49 (42%), Gaps = 6/49 (12%)
Query: 1224 WTAWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPTELTQEKTCPVTPC 1272
W W+ECS+TCG G S R + + C + +TC C
Sbjct: 39 WGPWSECSRTCGGGASYSLRRCL------SSKSCEGRNIRYRTCSNVDC 81
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 89.7 bits (221), Expect = 2e-17
Identities = 92/348 (26%), Positives = 134/348 (38%), Gaps = 65/348 (18%)
Query: 776 PCILVPESVWQGITGS-SEACGKGLQTRAVSCISDDNRSAEMMECLKQTNGM--PLLVQE 832
P P W + S +CG G C+ D N C +T + P +
Sbjct: 869 PATKRPAYTWSIVQSECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNA 928
Query: 833 CTVPCREDCTFTAWSKFTPCSTNCEA-TKSRRRQLTGKSR-KKEKCQDSDLYPL-VETEL 889
+ P + +++ CS C +SR+ Q K +KE+ L P+ T++
Sbjct: 929 FSCPA-----YWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQV 983
Query: 890 CPCDEFISQPY---GNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSDKNGRP 946
C+ P G WS C SK CG G+R R + C
Sbjct: 984 QACNSHACPPQWSLGPWSQC------------------SKTCGRGVRKRELLCKGSAAET 1025
Query: 947 VDPSFCSS--SGYIQEKCVIP-CPFDCKLSDW--SSWGSCSSSCGIGVRIRSKWLKEKPY 1001
+ S C+S +QE CV+ CP + +L W SSW CS++CG+GVR R EK +
Sbjct: 1026 LPESQCTSLPRPELQEGCVLGRCPKNSRLQ-WVASSWSECSATCGLGVRKREMKCSEKGF 1084
Query: 1002 NG------GRPC-----PKLDLKNQAQVHEAVPCYSECNQYS-WVVEHWSSCKINNELRS 1049
G R C P LDL+ A P + N + W W C +
Sbjct: 1085 QGKLITFPERRCRNIKKPNLDLEETCN-RRACPAHPVYNMVAGWYSLPWQQCTVT----- 1138
Query: 1050 LRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQSCSL-MCP 1096
CGGG Q+R + CV S+ C + PP ++C+ CP
Sbjct: 1139 --CGGGVQTRSVHCVQQGR------PSSSCLLHQKPPVLRACNTNFCP 1178
Score = 80.1 bits (196), Expect = 2e-14
Identities = 82/348 (23%), Positives = 118/348 (33%), Gaps = 90/348 (25%)
Query: 505 PCEDPMCYRWLASEGICFPDHGKCGLGHRILKAVCQNDRGEDVSGSLCPVPPPP--ERKS 562
P Y W + C CG G+ +KA+C D+ V+ S C P E K
Sbjct: 869 PATKRPAYTWSIVQSECSVS---CGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKI 925
Query: 563 CEIPCRMDCVLSEWT--EWSSCSQSCSNKNSDGK---------QTRSRTILALAGEGGKP 611
C C + W EWS+CS++C+ K Q + +L
Sbjct: 926 CNA---FSCP-AYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSL------- 974
Query: 612 CPPSQALQEHRLCNDHSCMQLHWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRR 671
CP S Q + CN H+C W PW CS+ TCG G++ R
Sbjct: 975 CPVSTPTQV-QACNSHACPP-QWSLGPWSQCSK-----------------TCGRGVRKRE 1015
Query: 672 VFCVKSHVGQVMTKRCPDSTRPETVRPCFL-PCKKDC-IVTAFSEWTPCPRMCQAGNATV 729
+ C S + +C RPE C L C K+ + S W+ C C G
Sbjct: 1016 LLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLG---- 1071
Query: 730 KQSRYRIIIQEAANGGQECPDTLYEERECEDVS-------------LCP-------VYRW 769
R + + G + + ER C ++ CP V W
Sbjct: 1072 ----VRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGW 1127
Query: 770 KPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCISDDNRSAEMM 817
W C + CG G+QTR+V C+ S+ +
Sbjct: 1128 YSLPWQQCTV--------------TCGGGVQTRSVHCVQQGRPSSSCL 1161
Score = 54.7 bits (130), Expect = 7e-07
Identities = 65/267 (24%), Positives = 103/267 (38%), Gaps = 40/267 (14%)
Query: 1131 LNSRTCAEDSQ--VQPCLLNENCFQFQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSDG 1188
+NS C+ ++ +P + N + EWSTC + C G ++R + CV
Sbjct: 908 VNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKA----CAGGQQSRKIQCV--QK 961
Query: 1189 KPVSMDQCEQHNLEKPQRMSIPCLVE-CVVNCQLSGWTA--WTECSQTCGHGGRMSRTRF 1245
KP ++ H+L +S P V+ C + W+ W++CS+TCG G R +
Sbjct: 962 KPFQKEEAVLHSLCP---VSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVR--KREL 1016
Query: 1246 IIMPTQGEGRP------CPTELTQE----KTCPVTPCYSWVLGNWSACKLEGGDCGEGVQ 1295
+ + E P P QE CP WV +WS C CG GV+
Sbjct: 1017 LCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSEC---SATCGLGVR 1073
Query: 1296 IRSLSCM---VHSGSISHAAGRVEDALCGEMPFQDSILKQLCSVPCPGDCHLTEWSE--W 1350
R + C I+ R + + +++ ++ C P + W W
Sbjct: 1074 KREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAH-PVYNMVAGWYSLPW 1132
Query: 1351 STCELTCIDGRSFETV-----GRQSRS 1372
C +TC G +V GR S S
Sbjct: 1133 QQCTVTCGGGVQTRSVHCVQQGRPSSS 1159
Score = 52.0 bits (123), Expect = 5e-06
Identities = 73/293 (24%), Positives = 106/293 (36%), Gaps = 69/293 (23%)
Query: 267 GYQTRQVSCTRS---DGQNAMLSLCLQDSFPLTVQSCIMPKDCETSQWS--SWSPCSKTC 321
G Q+R++ C + + A+L S P VQ+C QWS WS CSKTC
Sbjct: 950 GQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQAC--NSHACPPQWSLGPWSQCSKTC 1007
Query: 322 RSGSLLPGFRSRSRNVKHMAIG--GGKECPELLEKEACIVEGELLQQCP---RYSWRTSE 376
G R R K A +C L E + EG +L +CP R W S
Sbjct: 1008 GR-----GVRKRELLCKGSAAETLPESQCTSLPRPE--LQEGCVLGRCPKNSRLQWVASS 1060
Query: 377 WKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKALCV 436
W EC + CG G++ RE+ C++ + K ++ P + +
Sbjct: 1061 WSECSAT----------------CGLGVRKREMKCSEK-----GFQGKLITFPERRCRNI 1099
Query: 437 GPAPLP-SQLCN-IPCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPA 494
L + CN C + + + W + C G G +TR H + + P+
Sbjct: 1100 KKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCG-GGVQTRSVHCVQQGR-PS 1157
Query: 495 GHCPHLVESVP-----C-----------EDPMC---YRWLASEGICFPDHGKC 528
C L+ P C EDP C + W P HG C
Sbjct: 1158 SSC--LLHQKPPVLRACNTNFCPAPEKREDPSCVDFFNWCH----LVPQHGVC 1204
Score = 49.3 bits (116), Expect = 3e-05
Identities = 77/323 (23%), Positives = 109/323 (33%), Gaps = 78/323 (24%)
Query: 21 CTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFRVCDWHSDLFQWEVSDW 80
C+ CG G + +A+ C + S C +P E ++C+ S W +W
Sbjct: 885 CSVSCGGGYINVKAI-CLRDQNTQVNSSFCSAKTKPVTEP---KICNAFSCPAYWMPGEW 940
Query: 81 HHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKL---NRTVVANEICEHFALQPPT 137
C + C Q Q R ++C+QK V + +C + PT
Sbjct: 941 STC-------------SKACAGGQ---QSRKIQCVQKKPFQKEEAVLHSLCP---VSTPT 981
Query: 138 E-QACLI-PCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPNLTESRAC 195
+ QAC CP + PWS CSK CG+ ++ R L G L ES+
Sbjct: 982 QVQACNSHACPPQWSLG---PWSQCSKTCGRGVRKREL------LCKGSAAETLPESQCT 1032
Query: 196 DAP-----ISCPLGEEEYTFSLK--VGPWSKC----------RLPHLKEINPSGRTV--- 235
P C LG L+ WS+C R E G+ +
Sbjct: 1033 SLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFP 1092
Query: 236 -----------LDFNSDSNERVTFKHQSYK--AHHHSKSW-----AIEIGYQTRQVSCTR 277
LD N R H Y A +S W G QTR V C +
Sbjct: 1093 ERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQ 1152
Query: 278 SDGQNAMLSLCLQDSFPLTVQSC 300
Q S CL P +++C
Sbjct: 1153 ---QGRPSSSCLLHQKPPVLRAC 1172
Score = 47.0 bits (110), Expect = 1e-04
Identities = 45/168 (26%), Positives = 62/168 (36%), Gaps = 29/168 (17%)
Query: 16 GPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSC-FRVCDWHSDLFQ 74
GPW +C+ CG GV+ R + C T S C RP + C C +S L Q
Sbjct: 998 GPWSQCSKTCG-RGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRL-Q 1055
Query: 75 WEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMV-----RCIQKLNRTVVANEICE 129
W S W C A + R E ++ G Q +++ RC + E C
Sbjct: 1056 WVASSWSEC----SATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCN 1111
Query: 130 HFALQPPTEQACLIPCPRDCVVSEF-----LPWSNCSKGCGKKLQHRT 172
A CP V + LPW C+ CG +Q R+
Sbjct: 1112 RRA------------CPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRS 1147
Score = 44.3 bits (103), Expect = 0.001
Identities = 83/348 (23%), Positives = 113/348 (32%), Gaps = 121/348 (34%)
Query: 367 CPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEV 426
CP Y W EW C + C GG Q+R++ C Q P +
Sbjct: 931 CPAY-WMPGEWSTCSKA----------------CAGGQQSRKIQCVQKKPF-------QK 966
Query: 427 SRPVEKALCVGPAPLPSQLCNIPCSTDCIVSSWS--AWGLCIHENCHDPQGKKGFRTRQR 484
V +LC P Q CN + WS W C + C G R+R
Sbjct: 967 EEAVLHSLCPVSTPTQVQACN----SHACPPQWSLGPWSQC-SKTC-------GRGVRKR 1014
Query: 485 HVLME----STGPAGHC-----PHLVESV---PCEDPMCYRWLASE-GICFPDHGKCGLG 531
+L + T P C P L E C +W+AS C CGLG
Sbjct: 1015 ELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSEC---SATCGLG 1071
Query: 532 HRILKAVCQNDRGEDVSGSLCPVPPPPERKSCEIPCRMDCVLSEWTEWSSCSQSCSNKNS 591
R + C + G L PER+ CR + N
Sbjct: 1072 VRKREMKCSE---KGFQGKLITF---PERR-----CR----------------NIKKPNL 1104
Query: 592 DGKQTRSRTILALAGEGGKPCPPSQALQEHRLCNDHSCMQLHWETSPWGPCSEDTLVTAL 651
D ++T +R + CP H + N M W + PW C+
Sbjct: 1105 DLEETCNR----------RACP------AHPVYN----MVAGWYSLPWQQCT-------- 1136
Query: 652 NATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPETVRPC 699
TCG G+QTR V CV+ G+ + C +P +R C
Sbjct: 1137 ---------VTCGGGVQTRSVHCVQQ--GR-PSSSCLLHQKPPVLRAC 1172
Score = 40.0 bits (92), Expect = 0.018
Identities = 18/56 (32%), Positives = 26/56 (46%)
Query: 1217 VNCQLSGWTAWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPTELTQEKTCPVTPC 1272
++ Q S W+ W+ECS+TCG G + Q G CP + C + PC
Sbjct: 588 IHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPC 643
Score = 39.3 bits (90), Expect = 0.030
Identities = 45/205 (21%), Positives = 73/205 (35%), Gaps = 45/205 (21%)
Query: 267 GYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCETSQW--SSWSPCSKTCRSG 324
GY + C R S C + P+T C + W WS CSK C G
Sbjct: 892 GYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCP-AYWMPGEWSTCSKACAGG 950
Query: 325 SLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEGELLQQCPRYS----WRTSEWKEC 380
+SR ++ + ++ +L + +Q C ++ W W +C
Sbjct: 951 -------QQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQC 1003
Query: 381 QVSLLLEQQDPHWHVTGPVCGGGIQTREVYC----AQSVPAAAALRAKEVSRPVEKALCV 436
CG G++ RE+ C A+++P + + + RP + CV
Sbjct: 1004 ----------------SKTCGRGVRKRELLCKGSAAETLPES---QCTSLPRPELQEGCV 1044
Query: 437 -GPAPLPSQLCNIPCSTDCIVSSWS 460
G P S+L + SSWS
Sbjct: 1045 LGRCPKNSRL-------QWVASSWS 1062
Score = 38.9 bits (89), Expect = 0.040
Identities = 18/45 (40%), Positives = 23/45 (51%), Gaps = 1/45 (2%)
Query: 965 PCPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKE-KPYNGGRPCP 1008
P P + S WS W CS +CG GV+ + + KP GG CP
Sbjct: 585 PRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCP 629
Score = 31.6 bits (70), Expect = 6.3
Identities = 39/172 (22%), Positives = 58/172 (33%), Gaps = 41/172 (23%)
Query: 157 WSNCSKGCGKKLQHRTRA---VIAPPLFGGLQCPNLTESRACDAPISCPLGEEEYTFSLK 213
WS+CS+ KK +A V P G + P+ + DA C ++ F K
Sbjct: 474 WSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQC-----KWQFGAK 528
Query: 214 VGPWSKCRLPHLKEINPSGRTVLDFNSDSNERVTFKHQSYKAHHHSKSWAIEIGYQTRQV 273
C L +K+I S W +G++
Sbjct: 529 A---KLCSLGFVKDICKS-----------------------------LWCHRVGHRCETK 556
Query: 274 SCTRSDGQNAMLSL-CLQDSFPLTVQSCIMPKDCETSQWSSWSPCSKTCRSG 324
++G LS+ C Q + P + S WS WS CS+TC G
Sbjct: 557 FMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGG 608
Score = 31.6 bits (70), Expect = 6.3
Identities = 15/37 (40%), Positives = 21/37 (56%), Gaps = 1/37 (2%)
Query: 152 SEFLPWSNCSKGCGKKLQHRTRAVIAP-PLFGGLQCP 187
S + WS CS+ CG ++ + R P P +GGL CP
Sbjct: 593 SAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCP 629
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 89.4 bits (220), Expect = 3e-17
Identities = 126/545 (23%), Positives = 200/545 (36%), Gaps = 133/545 (24%)
Query: 849 FTPCSTNCEATKSRR------RQLTGKSRKKE--KCQDSDLYPLVET-ELCPCDEFISQP 899
+T CS +C RR + G+ + E KC + +++T L C ++I+
Sbjct: 427 WTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCPKWIAM- 485
Query: 900 YGNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSDKNGRPVDPSFCSSSGYIQ 959
WS C + CG GLR+R V C + G V +I+
Sbjct: 486 --EWSQCTVT------------------CGRGLRYRVVLCINHRGEHVGGCNPQLKLHIK 525
Query: 960 EKCVIPCPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVH 1019
E+CVIP P C S V + WLK QAQ
Sbjct: 526 EECVIPIP--CYKPKEKS----------PVEAKLPWLK-----------------QAQEL 556
Query: 1020 EAVPCYSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRC--VNTADGEGGAVDSN 1077
E +E + +++ E WS+C S CG G Q R+++C + T +
Sbjct: 557 EETRIATE--EPTFIPEPWSAC-------STTCGPGVQVREVKCRVLLTFTQTETELPEE 607
Query: 1078 LCNQDEIPPETQSCSLMCPNECVMS-----------------EWGLWSKCPQSCDPHTMQ 1120
C ++P E + C L +E S E+ ++ C +C +
Sbjct: 608 ECEGPKLPTE-RPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQE 666
Query: 1121 R-------RTRHLLRPSLNSRTCAEDSQVQPCLLNENCFQFQYNLTEWSTCQLSENAPCG 1173
+T+ + SL + Q C N ++++ W C +A CG
Sbjct: 667 AIAVCLHIQTQQTVNDSLCDMVHRPPAMSQAC--NTEPCPPRWHVGSWGPC----SATCG 720
Query: 1174 QGVRTRLLSCVCSDGKPVSMDQCEQHNLEKPQRMSIPCLVECVVNCQLSGW--TAWTECS 1231
G++TR + C+ P ++C EKP + +C GW W +CS
Sbjct: 721 VGIQTRDVYCLHPGETPAPPEECRD---EKPHALQACNQFDCP-----PGWHIEEWQQCS 772
Query: 1232 QTCGHGGRMSRTRFIIMPTQGEGRPCPTELTQ------EKTCPVTPCYSWV-LGNWSACK 1284
+TCG G + R + T G EL Q K+C T C + +G+WS C
Sbjct: 773 RTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCS 832
Query: 1285 LEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSILKQLCSVPCPGDCHL 1344
+ CG G+Q R C + A GR +P + + + L +P C +
Sbjct: 833 V---SCGVGIQRRKQVCQRLA-----AKGR-------RIPLSEMMCRDLPGLPLVRSCQM 877
Query: 1345 TEWSE 1349
E S+
Sbjct: 878 PECSK 882
Score = 72.4 bits (176), Expect = 3e-12
Identities = 129/598 (21%), Positives = 203/598 (33%), Gaps = 148/598 (24%)
Query: 611 PCPPSQALQEHRLCNDHSCMQLHWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTR 670
PCP S +E + DH WE +PW CS +CG GIQ R
Sbjct: 400 PCPSSDGFKEI-MPYDHFQPLPRWEHNPWTACS-----------------VSCGGGIQRR 441
Query: 671 RVFCVKS----HVGQVMTKRCPDSTRPETVRPCFLPCKKDCIVTAFSEWTPCPRMCQAGN 726
CV+ + QV +C + +P+ ++ C L DC EW+ C C G
Sbjct: 442 SFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNL---FDCPKWIAMEWSQCTVTCGRG- 497
Query: 727 ATVKQSRYRIII----QEAANGGQECPDTLYEERECEDVSLCPVYRWKPQKWSP------ 776
RYR+++ + GG L+ + EC + P+ +KP++ SP
Sbjct: 498 -----LRYRVVLCINHRGEHVGGCNPQLKLHIKEEC----VIPIPCYKPKEKSPVEAKLP 548
Query: 777 -------------CILVPESVWQGITGSSEACGKGLQTRAVSCI-------SDDNRSAEM 816
P + + + S CG G+Q R V C ++ E
Sbjct: 549 WLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEE 608
Query: 817 MECLKQTNGMPLLVQECT---------VPCREDCTFT---AWSKFTPCSTNCEATKSRRR 864
E K P L++ C +P ED T ++ FTPC+ C
Sbjct: 609 CEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAI 668
Query: 865 QLTGKSRKKEKCQDS---------DLYPLVETELCPCDEFISQPYGNWSDCIL------- 908
+ + ++ DS + TE CP + G+W C
Sbjct: 669 AVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHV----GSWGPCSATCGVGIQ 724
Query: 909 ---------------PEGRRE--PHR-----------GLRV---QADSKECGEGLRFRAV 937
PE R+ PH G + Q S+ CG G + R V
Sbjct: 725 TRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRV 784
Query: 938 AC----SDKNGRPVDPSFCSSSGYIQEKCVI--PCPFDCKLSDWSSWGSCSSSCGIGVRI 991
C +D + + C K CP + DWS CS SCG+G++
Sbjct: 785 TCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDWSK---CSVSCGVGIQ- 840
Query: 992 RSKWLKEKPYNGGRPCPKLDLKNQAQVHEAVPCYSECNQYSWVVEHWSSCKINNELRSLR 1051
R K + ++ GR P ++ + +P C KI +E+++
Sbjct: 841 RRKQVCQRLAAKGRRIPLSEM--MCRDLPGLPLVRSCQMP-------ECSKIKSEMKTKL 891
Query: 1052 CGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEWGLWSK 1109
G Q ++ V E ++ + ++ + P T S + CP W K
Sbjct: 892 GEQGPQILSVQRVYIQTREEKRINLTIGSRAYLLPNT-SVIIKCPVRRFQKSLIQWEK 948
Score = 69.7 bits (169), Expect = 2e-11
Identities = 142/612 (23%), Positives = 205/612 (33%), Gaps = 160/612 (26%)
Query: 310 QW--SSWSPCSKTCRSGSLLPGFRSRSRNVK--------HMAIGGGKECPELLE--KEAC 357
QW + + PC+ TC G L +K H K P+L E + C
Sbjct: 342 QWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPC 401
Query: 358 --------IVEGELLQQCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREV 409
I+ + Q PR W + W C VS CGGGIQ R
Sbjct: 402 PSSDGFKEIMPYDHFQPLPR--WEHNPWTACSVS----------------CGGGIQRRSF 443
Query: 410 YCAQSVPAAAALRAKEVSRPVEKALCV-GPAPLPSQLCNIPCSTDCIVSSWSAWG----- 463
C + L+ VE+ C+ P P Q CN+ I WS
Sbjct: 444 VCVEESMHGEILQ-------VEEWKCMYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGR 496
Query: 464 -------LCI-HENCH----DPQGKKGFRTRQRHVL-------MESTGPAGHCPHLVES- 503
LCI H H +PQ K ++ V+ E + P L ++
Sbjct: 497 GLRYRVVLCINHRGEHVGGCNPQLK--LHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQ 554
Query: 504 ------VPCEDPMCYR--WLASEGICFPDHGKCGLGHRILKAVCQNDRG---EDVSGSLC 552
+ E+P W A C P + R+L Q + E+ G
Sbjct: 555 ELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKL 614
Query: 553 PVPPP---------PERKSCEIPCRMDCVLS---EWTEWSSCSQSCSNKNSDGK------ 594
P P P + +IP D + E+ ++ C+ +C + +
Sbjct: 615 PTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHI 674
Query: 595 QTRSRTILALAGEGGKPCPPSQALQEHRLCNDHSCMQLHWETSPWGPCSEDTLVTALNAT 654
QT+ +L +P SQA CN C W WGPCS
Sbjct: 675 QTQQTVNDSLCDMVHRPPAMSQA------CNTEPCPP-RWHVGSWGPCS----------- 716
Query: 655 IGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPETVRPCFLPCKKDCIV-TAFS 713
ATCGVGIQTR V+C+ + C D +P ++ C + DC
Sbjct: 717 ------ATCGVGIQTRDVYCLHPGETPAPPEECRDE-KPHALQAC---NQFDCPPGWHIE 766
Query: 714 EWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQ--ECPDTLYEERECEDVSLCPVYRWKP 771
EW C R C G Q+R R+ ++ G D L + + C P
Sbjct: 767 EWQQCSRTCGGGT----QNR-RVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPP 821
Query: 772 Q----KWSPCILVPESVWQGITGSSEACGKGLQTRAVSC--ISDDNRSAEMMECL-KQTN 824
WS C S +CG G+Q R C ++ R + E + +
Sbjct: 822 HLAVGDWSKC--------------SVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLP 867
Query: 825 GMPLLVQECTVP 836
G+P LV+ C +P
Sbjct: 868 GLP-LVRSCQMP 878
Score = 67.4 bits (163), Expect = 1e-10
Identities = 145/606 (23%), Positives = 223/606 (36%), Gaps = 138/606 (22%)
Query: 21 CTGDCGPGGVQSRAVWCFHV-------DGWTSHLSNCGESNRP-PKERSCFRVCDWHSDL 72
CT CG GG Q + C + D + + E+ +P PK + C SD
Sbjct: 351 CTVTCG-GGYQLNSAECVDIRLKRVVPDHYCHYYP---ENVKPKPKLKECSMDPCPSSDG 406
Query: 73 FQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKL--NRTVVANEICEH 130
F+ E+ + H P R E P TA V+ G+Q R C+++ + E
Sbjct: 407 FK-EIMPYDH--FQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCM 463
Query: 131 FALQPPTEQAC-LIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVI---APPLFGGLQC 186
+A +P Q C L CP+ + WS C+ CG+ L++R I + G
Sbjct: 464 YAPKPKVMQTCNLFDCPKWIAME----WSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQ 519
Query: 187 PNLTESRACDAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDSNERV 246
L C PI C +E+ K LP LK+ T + + E
Sbjct: 520 LKLHIKEECVIPIPCYKPKEKSPVEAK--------LPWLKQAQELEETRI-----ATEEP 566
Query: 247 TFKHQSYKAHHHSKSWAIEIGYQTRQVSC------TRSDGQ---------------NAML 285
TF + + A S G Q R+V C T+++ + +L
Sbjct: 567 TFIPEPWSA----CSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLL 622
Query: 286 SLCLQDSFPLTVQSCI-MPKDCETS---QWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMA 341
C D P + + I +P+D ET+ +++ ++PC+ TC G + + +A
Sbjct: 623 EAC--DESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGG-----------HQEAIA 669
Query: 342 IGGGKECPELLEKEACIVEGELLQQCPRYSWRTSEWKECQVSLLLEQQDPHWHV--TGP- 398
+ + + + C +++ + P S + C E P WHV GP
Sbjct: 670 VCLHIQTQQTVNDSLC----DMVHRPPAMS------QACNT----EPCPPRWHVGSWGPC 715
Query: 399 --VCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKALCVGPAPLPSQLCN-IPCSTDCI 455
CG GIQTR+VYC L E P E+ C P Q CN C
Sbjct: 716 SATCGVGIQTRDVYC---------LHPGETPAPPEE--CRDEKPHALQACNQFDCPPGWH 764
Query: 456 VSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVESVPCEDP------ 509
+ W C G T+ R V G +L + + C+ P
Sbjct: 765 IEEWQQ----CSRTC-------GGGTQNRRVTCRQLLTDGSFLNLSDEL-CQGPKASSHK 812
Query: 510 MCYRWLASEGICFPDHGK----CGLGHRILKAVCQ----NDRGEDVSGSLC-PVPPPPER 560
C R + D K CG+G + K VCQ R +S +C +P P
Sbjct: 813 SCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLV 872
Query: 561 KSCEIP 566
+SC++P
Sbjct: 873 RSCQMP 878
Score = 67.4 bits (163), Expect = 1e-10
Identities = 88/350 (25%), Positives = 124/350 (35%), Gaps = 93/350 (26%)
Query: 513 RWLASEGICFPDHGKCGLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSCEIPCRMDCV 572
RW S + H K IL+A D +G PPP E
Sbjct: 1388 RWPESRIVFLQGHKKY-----ILQATNTRTNSNDPTGE----PPPQEP------------ 1426
Query: 573 LSEWTEWSSCSQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEH--------RLC 624
E WS CS +C + + + R + ++A E S+AL +H C
Sbjct: 1427 FWEPGNWSHCSATCGHLGA--RIQRPQCVMANGQE------VSEALCDHLQKPLAGFEPC 1478
Query: 625 NDHSCMQLHWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVG---Q 681
N C W TS W CS +CG G +R+V C ++ Q
Sbjct: 1479 NIRDC-PARWFTSVWSQCS-----------------VSCGEGYHSRQVTCKRTKANGTVQ 1520
Query: 682 VMTKR-CPDSTRPETVRPCF-LPCKKDCIVTAFSEWTP---CPRMCQAGNATVKQSRYRI 736
V++ R C RP +PCF PC +W P CP C G A Q R+
Sbjct: 1521 VVSPRACAPKDRPLGRKPCFGHPCV---------QWEPGNRCPGRCM-GRAVRMQQRHTA 1570
Query: 737 IIQEAANGGQECPDTLYEERECEDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACG 796
+++ + R C C V W W PC + ACG
Sbjct: 1571 CQHNSSDSNCDDRKRPTLRRNCTS-GACDVC-WHTGPWKPC--------------TAACG 1614
Query: 797 KGLQTRAVSCISDDN-RSAEMMECLKQTNGMPLLVQECTVP-CREDCTFT 844
+G Q+R V CI + + C+++ P+ + C P C DCT T
Sbjct: 1615 RGFQSRKVDCIHTRSCKPVAKRHCVQKKK--PISWRHCLGPSCDRDCTDT 1662
Score = 64.7 bits (156), Expect = 7e-10
Identities = 111/504 (22%), Positives = 158/504 (31%), Gaps = 123/504 (24%)
Query: 267 GYQTRQVSCTRSDGQNAMLSL----CLQDSFPLTVQSCIMPKDCETSQWSSWSPCSKTCR 322
G Q R C +L + C+ P +Q+C + DC WS C+ TC
Sbjct: 437 GIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNL-FDCPKWIAMEWSQCTVTCG 495
Query: 323 SGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEGELLQQCPRYSWRTSEWKECQV 382
G + +H +GG +L KE C++ P Y + E ++
Sbjct: 496 RGLRYRVVLCINHRGEH--VGGCNPQLKLHIKEECVIP------IPCYKPKEKSPVEAKL 547
Query: 383 SLLLEQQDPH---------------WHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVS 427
L + Q+ W CG G+Q REV C E
Sbjct: 548 PWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCR----VLLTFTQTETE 603
Query: 428 RPVEKALCVGPA-----------------------PLPSQLCNI---------PCSTDCI 455
P E+ C GP PLP PC+ C+
Sbjct: 604 LPEEE--CEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCV 661
Query: 456 VSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVESVPCEDPMCYRW- 514
A +C+H +T+Q + +S H P + +P RW
Sbjct: 662 GGHQEAIAVCLH-----------IQTQQ--TVNDSLCDMVHRPPAMSQACNTEPCPPRWH 708
Query: 515 LASEGICFPDHGKCGLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSCEIPCRMDCVLS 574
+ S G C CG+G + C + C P ++C + DC
Sbjct: 709 VGSWGPC---SATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACN---QFDCP-P 761
Query: 575 EW--TEWSSCSQSCSNKNSDGKQTRSRTILALAGEGG------KPCPPSQALQEHRLCND 626
W EW CS++C G Q R T L +G + C +A H+ C
Sbjct: 762 GWHIEEWQQCSRTCGG----GTQNRRVTCRQLLTDGSFLNLSDELCQGPKA-SSHKSCAR 816
Query: 627 HSCMQLHWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFC----VKSHVGQV 682
C H W CS +CGVGIQ R+ C K +
Sbjct: 817 TDCPP-HLAVGDWSKCS-----------------VSCGVGIQRRKQVCQRLAAKGRRIPL 858
Query: 683 MTKRCPDSTRPETVRPCFLP-CKK 705
C D VR C +P C K
Sbjct: 859 SEMMCRDLPGLPLVRSCQMPECSK 882
Score = 64.3 bits (155), Expect = 9e-10
Identities = 110/495 (22%), Positives = 160/495 (32%), Gaps = 142/495 (28%)
Query: 17 PWGRCTGDCGPGGVQSRAVWC---------FHVDGWTSHLSNCGESNRPPKERSCFRVCD 67
PW C+ CG GG+Q R+ C V+ W C + +P ++C
Sbjct: 426 PWTACSVSCG-GGIQRRSFVCVEESMHGEILQVEEW-----KCMYAPKPKVMQTCNLF-- 477
Query: 68 WHSDLFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEI 127
D +W +W C VT GL++R+V CI V
Sbjct: 478 ---DCPKWIAMEWSQCT----------------VTCGRGLRYRVVLCINHRGEHVGG--- 515
Query: 128 CEHFALQPPTEQACLIPCP------------------------RDCVVSE---FL--PWS 158
C L+ ++ C+IP P + +E F+ PWS
Sbjct: 516 CNP-QLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWS 574
Query: 159 NCSKGCGKKLQHRTRAVIAPPLFGGLQCPNLTESRACDAPISCPLGEEEYTFSLKVGPWS 218
CS CG +Q R V L Q C+ P K+
Sbjct: 575 ACSTTCGPGVQ--VREVKCRVLLTFTQTETELPEEECEGP--------------KLPTER 618
Query: 219 KCRLPHLKEINPSGRTVLDFNSDSNERVTFKHQSYK------AHHHSKSWAIEIGYQTRQ 272
C L E S + DS +++ + H ++ A+ + QT+Q
Sbjct: 619 PCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQ 678
Query: 273 VSCTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCETSQW--SSWSPCSKTCRSGSLLPGF 330
T +D SLC P + + C +W SW PCS TC G
Sbjct: 679 ---TVND------SLCDMVHRPPAMSQACNTEPC-PPRWHVGSWGPCSATC-------GV 721
Query: 331 RSRSRNVKHMAIGGGKECPELLEKEACIVEGELLQQCPRY----SWRTSEWKECQVSLLL 386
++R+V + G PE E + LQ C ++ W EW++C
Sbjct: 722 GIQTRDVYCLHPGETPAPPEECRDE----KPHALQACNQFDCPPGWHIEEWQQC------ 771
Query: 387 EQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKALCVGPAPLPSQLC 446
CGGG Q R V C Q + + L + LC GP + C
Sbjct: 772 ----------SRTCGGGTQNRRVTCRQLLTDGSFLNLSD-------ELCQGPKASSHKSC 814
Query: 447 -NIPCSTDCIVSSWS 460
C V WS
Sbjct: 815 ARTDCPPHLAVGDWS 829
Score = 61.2 bits (147), Expect = 7e-09
Identities = 59/241 (24%), Positives = 96/241 (39%), Gaps = 51/241 (21%)
Query: 977 SWGSCSSSCG-IGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHEAV------------P 1023
+W CS++CG +G RI+ P+ + N +V EA+ P
Sbjct: 1432 NWSHCSATCGHLGARIQR--------------PQCVMANGQEVSEALCDHLQKPLAGFEP 1477
Query: 1024 CYSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNT-ADGEGGAVDSNLCNQD 1082
C W WS C ++ CG G SR++ C T A+G V C
Sbjct: 1478 CNIRDCPARWFTSVWSQCSVS-------CGEGYHSRQVTCKRTKANGTVQVVSPRACAPK 1530
Query: 1083 EIPPETQSCSLMCPNECVMSEWGLWSKCPQSCDPHTMQRRTRHLLRPSLNSRTCAEDSQV 1142
+ P + C + CV +W ++CP C ++ + RH +S + +D +
Sbjct: 1531 DRPLGRKPCF---GHPCV--QWEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRK- 1584
Query: 1143 QPCLLNENCFQFQ----YNLTEWSTCQLSENAPCGQGVRTRLLSCVCSDG-KPVSMDQCE 1197
+P L NC ++ W C A CG+G ++R + C+ + KPV+ C
Sbjct: 1585 RPTL-RRNCTSGACDVCWHTGPWKPC----TAACGRGFQSRKVDCIHTRSCKPVAKRHCV 1639
Query: 1198 Q 1198
Q
Sbjct: 1640 Q 1640
Score = 53.1 bits (126), Expect = 2e-06
Identities = 44/165 (26%), Positives = 63/165 (38%), Gaps = 41/165 (24%)
Query: 16 GPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKE-----RSCFRVCDWHS 70
G WG C+ CG G +Q+R V+C H GE+ PP+E + C+
Sbjct: 710 GSWGPCSATCGVG-IQTRDVYCLHP----------GETPAPPEECRDEKPHALQACNQFD 758
Query: 71 DLFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVAN---EI 127
W + +W C T G Q+R V C Q L N E+
Sbjct: 759 CPPGWHIEEWQQCSR----------------TCGGGTQNRRVTCRQLLTDGSFLNLSDEL 802
Query: 128 CEHFALQPPTEQACL-IPCPRDCVVSEFLPWSNCSKGCGKKLQHR 171
C+ + + ++C CP V + WS CS CG +Q R
Sbjct: 803 CQ--GPKASSHKSCARTDCPPHLAVGD---WSKCSVSCGVGIQRR 842
Score = 49.7 bits (117), Expect = 2e-05
Identities = 127/590 (21%), Positives = 202/590 (34%), Gaps = 133/590 (22%)
Query: 74 QWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHFAL 133
QW +D+ C VT G Q C+ + VV + C ++
Sbjct: 342 QWRQTDFFPCT----------------VTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPE 385
Query: 134 ----QPPTEQACLIPCPRDCVVSEFLP--------------WSNCSKGCGKKLQHRTRAV 175
+P ++ + PCP E +P W+ CS CG +Q R+
Sbjct: 386 NVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVC 445
Query: 176 IAPPLFGGLQCPNLTESRACDAP-----ISCPLGEEEYTFSLKVGPWSKCRLPHLKEINP 230
+ + G + + E + AP +C L + +++ WS+C + + +
Sbjct: 446 VEESMHG--EILQVEEWKCMYAPKPKVMQTCNLFDCPKWIAME---WSQCTVTCGRGLR- 499
Query: 231 SGRTVLDFNSDSNERVTFKHQSYKAHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQ 290
R VL N E V + K H + Y+ ++ S + + L+
Sbjct: 500 -YRVVLCIN-HRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELE 557
Query: 291 DSFPLTVQSCIMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPE 350
++ T + +P+ WS CS TC G + R VK + +
Sbjct: 558 ETRIATEEPTFIPE--------PWSACSTTCGPG-------VQVREVKCRVLLTFTQTET 602
Query: 351 LLEKEACIVEGE--------LLQQCPRYSWRTSEWKECQVSLLLEQQDPH-WHVTG---- 397
L +E C EG LL+ C + +E + L + + + W G
Sbjct: 603 ELPEEEC--EGPKLPTERPCLLEACD----ESPASRELDIPLPEDSETTYDWEYAGFTPC 656
Query: 398 -PVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKALC--VGPAPLPSQLCNI-PCSTD 453
C GG Q C + + V +LC V P SQ CN PC
Sbjct: 657 TATCVGGHQEAIAVCLHI----------QTQQTVNDSLCDMVHRPPAMSQACNTEPCPPR 706
Query: 454 CIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLM--ESTGPAGHC----PHLVESVPCE 507
V SW C G G +TR + L E+ P C PH +++
Sbjct: 707 WHVGSWGP--------CSATCG-VGIQTRDVYCLHPGETPAPPEECRDEKPHALQA---- 753
Query: 508 DPMCYRWLASEGICFPDHGK----CGLGHRILKAVCQNDRGE----DVSGSLCPVPPPPE 559
C ++ G + + CG G + + C+ + ++S LC P
Sbjct: 754 ---CNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASS 810
Query: 560 RKSCEIPCRMDCVLS-EWTEWSSCSQSCSNKNSDGKQTRSRTILALAGEG 608
KSC R DC +WS CS SC G Q R + LA +G
Sbjct: 811 HKSC---ARTDCPPHLAVGDWSKCSVSC----GVGIQRRKQVCQRLAAKG 853
Score = 47.8 bits (112), Expect = 9e-05
Identities = 59/237 (24%), Positives = 89/237 (37%), Gaps = 31/237 (13%)
Query: 1227 WTECSQTCGH-GGRMSRTRFIIMPTQGEGRPCPTELTQE----KTCPVTPCYS-WVLGNW 1280
W+ CS TCGH G R+ R + ++ Q L + + C + C + W W
Sbjct: 1433 WSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPARWFTSVW 1492
Query: 1281 SACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSILKQLCSVPCPG 1340
S C + CGEG R ++C + A G V+ +D + L PC G
Sbjct: 1493 SQCSV---SCGEGYHSRQVTC-----KRTKANGTVQVVSPRACAPKD---RPLGRKPCFG 1541
Query: 1341 DCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQSFENQDSCPQQVLET--RPCTG 1398
+W + C C+ GR+ + + R Q + +C + T R CT
Sbjct: 1542 H-PCVQWEPGNRCPGRCM-GRAV-----RMQQRHTACQHNSSDSNCDDRKRPTLRRNCTS 1594
Query: 1399 GKCYHYTWKASLWNNNERTVWCQRS-DGVNVTGGCSPQARPAAIRQCIPACRKPFSY 1454
G C W W T C R V + +P A R C+ +KP S+
Sbjct: 1595 GAC-DVCWHTGPW--KPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQK-KKPISW 1647
Score = 47.0 bits (110), Expect = 1e-04
Identities = 57/219 (26%), Positives = 87/219 (39%), Gaps = 46/219 (21%)
Query: 1161 WSTCQLSENAPCGQ-GVRTRLLSCVCSDGKPVSMDQCEQHNLEKPQRMSIPCLVECVVNC 1219
WS C +A CG G R + CV ++G+ VS C+ +L+KP PC + +C
Sbjct: 1433 WSHC----SATCGHLGARIQRPQCVMANGQEVSEALCD--HLQKPLAGFEPCNIR---DC 1483
Query: 1220 QLSGWTA-WTECSQTCGHG----------GRMSRTRFIIMPTQGEGRPCPTELTQEKTCP 1268
+T+ W++CS +CG G + + T ++ P + P K C
Sbjct: 1484 PARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRP---LGRKPCF 1540
Query: 1269 VTPCYSWVLGNWSACKLEGGDCGEGV--QIRSLSCMVHSGSISHAAGRVEDALCGEMPFQ 1326
PC W GN + G G V Q R +C H+ S S+ R +
Sbjct: 1541 GHPCVQWEPGN----RCPGRCMGRAVRMQQRHTACQ-HNSSDSNCDDR-----------K 1584
Query: 1327 DSILKQLCSVPCPGDCHLTEWSEWSTCELTCIDGRSFET 1365
L++ C+ C T W C C GR F++
Sbjct: 1585 RPTLRRNCTSGACDVCWHT--GPWKPCTAAC--GRGFQS 1619
Score = 45.8 bits (107), Expect = 3e-04
Identities = 99/457 (21%), Positives = 166/457 (36%), Gaps = 122/457 (26%)
Query: 1049 SLRCGGGTQSRKIRCVNTADGEGGAVDSNLCN----QDEIPPETQSCSL-MCPNECVMSE 1103
++ CGGG Q CV+ V + C+ + P+ + CS+ CP+ E
Sbjct: 352 TVTCGGGYQLNSAECVDIRLKR--VVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKE 409
Query: 1104 ------------W--GLWSKCPQSCDPHTMQRRTRHLLRPSLNSRTCAEDSQVQP--CL- 1146
W W+ C SC +QRR+ + S++ E QV+ C+
Sbjct: 410 IMPYDHFQPLPRWEHNPWTACSVSCGGG-IQRRSFVCVEESMHG----EILQVEEWKCMY 464
Query: 1147 -----LNENCFQF---QYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVS--MDQC 1196
+ + C F ++ EWS C ++ CG+G+R R++ C+ G+ V Q
Sbjct: 465 APKPKVMQTCNLFDCPKWIAMEWSQCTVT----CGRGLRYRVVLCINHRGEHVGGCNPQL 520
Query: 1197 EQHNLEKPQRMSIPCLV---ECVVNCQLSGWTA---------------------WTECSQ 1232
+ H +++ + IPC + V +L W W+ CS
Sbjct: 521 KLH-IKEECVIPIPCYKPKEKSPVEAKLP-WLKQAQELEETRIATEEPTFIPEPWSACST 578
Query: 1233 TCGHGGRMSRTRFIIMPT-----------QGEGRPCPTELT-QEKTCPVTPC-------- 1272
TCG G ++ + ++ T + EG PTE + C +P
Sbjct: 579 TCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPASRELDIPL 638
Query: 1273 -------YSWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPF 1325
Y W ++ C C G Q +++ +H V D+LC +M
Sbjct: 639 PEDSETTYDWEYAGFTPCT---ATCVGGHQ-EAIAVCLHI----QTQQTVNDSLC-DMVH 689
Query: 1326 QDSILKQLCSV-PCPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQSFENQD 1384
+ + Q C+ PCP H+ W C TC VG Q+R + + E
Sbjct: 690 RPPAMSQACNTEPCPPRWHV---GSWGPCSATC-------GVGIQTRD-VYCLHPGET-P 737
Query: 1385 SCPQQVLETRPCTGGKCYHYT----WKASLWNNNERT 1417
+ P++ + +P C + W W RT
Sbjct: 738 APPEECRDEKPHALQACNQFDCPPGWHIEEWQQCSRT 774
Score = 44.7 bits (104), Expect = 7e-04
Identities = 67/257 (26%), Positives = 102/257 (39%), Gaps = 50/257 (19%)
Query: 75 WEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHFALQ 134
WE +W HC +A C G + + +C+ N V+ +C+H LQ
Sbjct: 1428 WEPGNWSHC-------------SATC--GHLGARIQRPQCVMA-NGQEVSEALCDH--LQ 1469
Query: 135 PPTEQACLIPCP-RDCVVSEFLP-WSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPNLTES 192
P A PC RDC F WS CS CG+ R G +Q +
Sbjct: 1470 KPL--AGFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQ---VVSP 1524
Query: 193 RACDAPISCPLGEEEYTF--SLKVGPWSKC------RLPHLKEINPS-GRTVLDFNSDSN 243
RAC AP PLG + ++ P ++C R +++ + + D N D
Sbjct: 1525 RAC-APKDRPLGRKPCFGHPCVQWEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDR 1583
Query: 244 ERVTFKHQ----SYKAHHHSKSW-----AIEIGYQTRQVSC--TRSDGQNAMLSLCLQDS 292
+R T + + H+ W A G+Q+R+V C TRS A C+Q
Sbjct: 1584 KRPTLRRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRH-CVQKK 1642
Query: 293 FPLTVQSCIMP---KDC 306
P++ + C+ P +DC
Sbjct: 1643 KPISWRHCLGPSCDRDC 1659
Score = 43.5 bits (101), Expect = 0.002
Identities = 45/139 (32%), Positives = 52/139 (37%), Gaps = 34/139 (24%)
Query: 17 PWGRCTGDCGPGGV--QSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFR-VCD--WHSD 71
P RC G C V Q R C H S SNC + RP R+C CD WH+
Sbjct: 1549 PGNRCPGRCMGRAVRMQQRHTACQH----NSSDSNCDDRKRPTLRRNCTSGACDVCWHT- 1603
Query: 72 LFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHF 131
G KP TA C G Q R V CI + VA C
Sbjct: 1604 -------------------GPWKPCTAAC---GRGFQSRKVDCIHTRSCKPVAKRHCVQ- 1640
Query: 132 ALQPPTEQACLIP-CPRDC 149
+P + + CL P C RDC
Sbjct: 1641 KKKPISWRHCLGPSCDRDC 1659
Score = 42.0 bits (97), Expect = 0.005
Identities = 53/213 (24%), Positives = 76/213 (35%), Gaps = 43/213 (20%)
Query: 1275 WVLGNWSACKLEGGDCGE-GVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSILKQL 1333
W GNWS C CG G +I+ C++ +G V +ALC D + K L
Sbjct: 1428 WEPGNWSHC---SATCGHLGARIQRPQCVMANGQ------EVSEALC------DHLQKPL 1472
Query: 1334 CSV-PCP-GDCHLTEW--SEWSTCELTCIDGRSFETVGRQSRSRTFIIQSFENQDSCPQ- 1388
PC DC W S WS C ++C +G V + +Q + P+
Sbjct: 1473 AGFEPCNIRDCP-ARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKD 1531
Query: 1389 QVLETRPCTGGKCYHY--------TWKASLWNNNERTVWCQRSDGVNVTGGCSPQARPAA 1440
+ L +PC G C + +R CQ + C + RP
Sbjct: 1532 RPLGRKPCFGHPCVQWEPGNRCPGRCMGRAVRMQQRHTACQHNSS---DSNCDDRKRPTL 1588
Query: 1441 IRQCIP-AC-----RKPFSYCTQGGVCGCEKGY 1467
R C AC P+ CT C +G+
Sbjct: 1589 RRNCTSGACDVCWHTGPWKPCT----AACGRGF 1617
Score = 42.0 bits (97), Expect = 0.005
Identities = 52/244 (21%), Positives = 82/244 (33%), Gaps = 66/244 (27%)
Query: 258 HSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCETSQWSS-WSP 316
H + +G + ++ C ++GQ +LC PL +DC ++S WS
Sbjct: 1435 HCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPARWFTSVWSQ 1494
Query: 317 CSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEGELLQQCPRYSWRTSE 376
CS +C G + SR K G +++ AC + L + P + +
Sbjct: 1495 CSVSCGEG-----YHSRQVTCKRTKANG---TVQVVSPRACAPKDRPLGRKPCFGHPCVQ 1546
Query: 377 WK-------ECQVSLLLEQQ-------------------------------DPHWHVTGP 398
W+ C + QQ D WH TGP
Sbjct: 1547 WEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGACDVCWH-TGP 1605
Query: 399 ------VCGGGIQTREVYC--AQSVPAAAALRAKEVSRPVEKALCVGPAPLPSQLCNIPC 450
CG G Q+R+V C +S A + +P+ C+GP+ C
Sbjct: 1606 WKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPS----------C 1655
Query: 451 STDC 454
DC
Sbjct: 1656 DRDC 1659
Score = 41.6 bits (96), Expect = 0.006
Identities = 60/259 (23%), Positives = 79/259 (30%), Gaps = 90/259 (34%)
Query: 901 GNWSDCILPEGRREPHRGLRVQADSKECGE-GLRFRAVACSDKNGRPVDPSFCSSSGYIQ 959
GNWS C S CG G R + C NG+ V + C ++Q
Sbjct: 1431 GNWSHC------------------SATCGHLGARIQRPQCVMANGQEVSEALCD---HLQ 1469
Query: 960 EKCV--IPCPF-DCKLSDWSS-WGSCSSSCGIGVRIRSKWLKEKPYNG------------ 1003
+ PC DC ++S W CS SCG G R K NG
Sbjct: 1470 KPLAGFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAP 1529
Query: 1004 -----------GRPCPKLDLKNQA------------QVHEAVP----------------- 1023
G PC + + N+ Q H A
Sbjct: 1530 KDRPLGRKPCFGHPCVQWEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLR 1589
Query: 1024 --CYSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQ 1081
C S W W C + CG G QSRK+ C++T + V C Q
Sbjct: 1590 RNCTSGACDVCWHTGPWKPC-------TAACGRGFQSRKVDCIHTRSCK--PVAKRHCVQ 1640
Query: 1082 DEIPPETQSC-SLMCPNEC 1099
+ P + C C +C
Sbjct: 1641 KKKPISWRHCLGPSCDRDC 1659
Score = 35.0 bits (79), Expect = 0.57
Identities = 33/134 (24%), Positives = 47/134 (35%), Gaps = 33/134 (24%)
Query: 313 SWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELL----EKEACIVEGELLQQCP 368
+WS CS TC G + G+E E L +K E ++ CP
Sbjct: 1432 NWSHCSATC-------GHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCP 1484
Query: 369 RYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQ-----SVPAAAALRA 423
W TS W +C VS CG G +R+V C + +V +
Sbjct: 1485 A-RWFTSVWSQCSVS----------------CGEGYHSRQVTCKRTKANGTVQVVSPRAC 1527
Query: 424 KEVSRPVEKALCVG 437
RP+ + C G
Sbjct: 1528 APKDRPLGRKPCFG 1541
Score = 34.7 bits (78), Expect = 0.75
Identities = 17/49 (34%), Positives = 23/49 (46%), Gaps = 6/49 (12%)
Query: 1224 WTAWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPTELTQEKTCPVTPC 1272
W W++CS+TCG G S R + GR C + + KTC C
Sbjct: 81 WGDWSDCSRTCGGGASYSLRRCL------TGRNCEGQNIRYKTCSNHDC 123
Score = 34.7 bits (78), Expect = 0.75
Identities = 30/105 (28%), Positives = 38/105 (36%), Gaps = 26/105 (24%)
Query: 16 GPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFRVCDWHSDLFQW 75
GPW CT CG G QSR V C H S +P +R C + +
Sbjct: 1604 GPWKPCTAACG-RGFQSRKVDCIHT-----------RSCKPVAKRHCVQ---------KK 1642
Query: 76 EVSDWHHCVLVPYARGEVKPRTAECVTAQH----GLQHRMVRCIQ 116
+ W HC L P + T C+ +H L RC Q
Sbjct: 1643 KPISWRHC-LGPSCDRDCTDTTHYCMFVKHLNLCSLDRYKQRCCQ 1686
Score = 33.9 bits (76), Expect = 1.3
Identities = 20/78 (25%), Positives = 30/78 (38%), Gaps = 10/78 (12%)
Query: 304 KDCETSQWSSWSPCSKTCRSGS------LLPGFRSRSRNVKHMAIGGGKECP---ELLEK 354
KD W WS CS+TC G+ L G +N+++ +CP E
Sbjct: 74 KDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTC-SNHDCPPDAEDFRA 132
Query: 355 EACIVEGELLQQCPRYSW 372
+ C ++ Q Y W
Sbjct: 133 QQCSAYNDVQYQGHYYEW 150
Score = 31.2 bits (69), Expect = 8.3
Identities = 15/52 (28%), Positives = 22/52 (42%), Gaps = 7/52 (13%)
Query: 1038 WSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQ 1089
WS C S CGGG RC+ + EG + C+ + PP+ +
Sbjct: 84 WSDC-------SRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAE 128
>gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
sapiens]
Length = 1074
Score = 89.0 bits (219), Expect = 3e-17
Identities = 86/331 (25%), Positives = 123/331 (37%), Gaps = 56/331 (16%)
Query: 423 AKEVSRPVEKALCVGPAPLPSQLCNIPCSTDCIVSSWSA--WGLCIHENCHDPQGKKGFR 480
++E +++ C A P+ PC W A W C +C + +
Sbjct: 693 SRESGEELDERSCAAGARPPAS--PEPCHGTPCPPYWEAGEWTSC-SRSCGPGTQHRQLQ 749
Query: 481 TRQRHVLMESTGPAGHCPHLVE---SVPCEDPMCYRWLASE--GICFPDHGKCGLGHRIL 535
RQ S+ P C HL + C+ +C W C +CG G R
Sbjct: 750 CRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQCSV---RCGRGQRSR 806
Query: 536 KAVCQNDRGEDVSGSLCPV--PPPPERKSCEI-PCRMDCVLSEWTEWSSCSQSCSNKNSD 592
+ C + G++VS C P PP R++C++ PC S+W+ S CS C
Sbjct: 807 QVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWS--SKCSAECGT---- 860
Query: 593 GKQTRSRTILAL----------AGEG-GKPCPPSQALQEHRLCNDHSCMQL-HWETSPWG 640
G Q RS L AG G G+ CP + R C+ C + W T PWG
Sbjct: 861 GIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCERTWRWYTGPWG 920
Query: 641 PCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVK---SHVGQVMTKRCPDSTRPETVR 697
CS + CG G Q R + CV + C RP ++
Sbjct: 921 ECSSE-----------------CGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQ 963
Query: 698 PCFLPCKKDCIVTAFSEWTPCPRMCQAGNAT 728
PC +D + + W+PC R CQ G T
Sbjct: 964 PCQGQACQDRWFS--TPWSPCSRSCQGGTQT 992
Score = 84.7 bits (208), Expect = 6e-16
Identities = 103/398 (25%), Positives = 140/398 (35%), Gaps = 74/398 (18%)
Query: 781 PESVWQ--GITGSSEACGKGLQTRAVSCISDDNRSAEMMECLKQTNGMPLLVQECTVPCR 838
P + W+ G + S +CGKG+ CIS ++ E+ E P E PC
Sbjct: 664 PAAYWKRVGHSACSASCGKGVWRPIFLCISRES-GEELDERSCAAGARPPASPE---PCH 719
Query: 839 EDCTFTAWS--KFTPCSTNC-EATKSRRRQLT------GKSRKKEKCQDSDLYPLVET-E 888
W ++T CS +C T+ R+ Q G S E+C + ++ +
Sbjct: 720 GTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQ 779
Query: 889 LCPCDEF-ISQPYGNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSDKNGRPV 947
L C + + P WS C S CG G R R V C NG V
Sbjct: 780 LRLCGHWEVGSP---WSQC------------------SVRCGRGQRSRQVRCVGNNGDEV 818
Query: 948 DPSFCSS---SGYIQEKCVI-PCPFDCKLSDWSSWGSCSSSCGIGVRIRS---------- 993
C+S +E C + PC SDWSS CS+ CG G++ RS
Sbjct: 819 SEQECASGPPQPPSREACDMGPCTTAWFHSDWSS--KCSAECGTGIQRRSVVCLGSGAAL 876
Query: 994 -KWLKEKPYNGGRPCPKLDLKNQAQVHEAVPCYSECNQYSWVVEHWSSCKINNELRSLRC 1052
E G+ CP + PC + W W C S C
Sbjct: 877 GPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCE---RTWRWYTGPWGEC-------SSEC 926
Query: 1053 GGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEW--GLWSKC 1110
G GTQ R I CV+ E + C+ PP Q C + W WS C
Sbjct: 927 GSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQ----GQACQDRWFSTPWSPC 982
Query: 1111 PQSCDPHTMQRRTRHLLRPSLNSRTC---AEDSQVQPC 1145
+SC T R + L S C S+ +PC
Sbjct: 983 SRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPC 1020
Score = 77.4 bits (189), Expect = 1e-13
Identities = 108/456 (23%), Positives = 152/456 (33%), Gaps = 111/456 (24%)
Query: 967 PFDCKLSDWSSWG--SCSSSCGIGV---------RIRSKWLKEKPYNGGRPCPKLDLKNQ 1015
P + W G +CS+SCG GV R + L E+ G P
Sbjct: 660 PLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPA------ 713
Query: 1016 AQVHEAVPCY-SECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAV 1074
PC+ + C Y W W+SC S CG GTQ R+++C G G +V
Sbjct: 714 ----SPEPCHGTPCPPY-WEAGEWTSC-------SRSCGPGTQHRQLQCRQEFGGGGSSV 761
Query: 1075 DSNLCNQDEIPPETQSCSL-MCPNECVMSEWGLWSKCPQSCDPHTMQRRTRHLLR--PSL 1131
C P TQSC L +C + V S WS+C C R+ R + +
Sbjct: 762 PPERCGHLPRPNITQSCQLRLCGHWEVGSP---WSQCSVRCGRGQRSRQVRCVGNNGDEV 818
Query: 1132 NSRTCAEDSQVQPCLLNENCFQFQYNLTEWSTCQLSE--NAPCGQGVRTRLLSCVCSDGK 1189
+ + CA P E C T W S +A CG G++ R + C+ S G
Sbjct: 819 SEQECASGPPQPPS--REAC-DMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLGS-GA 874
Query: 1190 PVSMDQCEQHNLEKPQRMSIPCLVECVVNCQLSGWTAWTECSQTCGHGGRMSRTRFIIMP 1249
+ Q E A Q+C G R
Sbjct: 875 ALGPGQGE----------------------------AGAGTGQSCPTGSR---------- 896
Query: 1250 TQGEGRPCPTELTQEKTCPVTPCYSWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSIS 1309
P ++ P + W G W C E CG G Q R + C+ G+
Sbjct: 897 --------PPDMRACSLGPCERTWRWYTGPWGECSSE---CGSGTQRRDIICVSKLGTEF 945
Query: 1310 HAAGRVEDALCGEMPFQDSILKQLCSVPCPGDCHLTEW--SEWSTCELTCIDGRSFETVG 1367
+ + C +P ++ PC G W + WS C +C G V
Sbjct: 946 NV---TSPSNCSHLPRPPAL------QPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQ 996
Query: 1368 RQSRSRTFIIQSFENQDSCPQQVLET--RPCTGGKC 1401
S ++T CP Q+ + RPC C
Sbjct: 997 CLSTNQTL-------STRCPPQLRPSRKRPCNSQPC 1025
Score = 72.0 bits (175), Expect = 4e-12
Identities = 89/332 (26%), Positives = 120/332 (36%), Gaps = 91/332 (27%)
Query: 15 AGPWGRCTGDCGPGGVQSRAVWC---FHVDGWTSHLSNCGESNRPPKERSC-FRVCDWHS 70
AG W C+ CGP G Q R + C F G + CG RP +SC R+C
Sbjct: 729 AGEWTSCSRSCGP-GTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCG--- 784
Query: 71 DLFQWEV-SDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICE 129
WEV S W C V G + R VRC+ N V+ + C
Sbjct: 785 ---HWEVGSPWSQC----------------SVRCGRGQRSRQVRCVGN-NGDEVSEQECA 824
Query: 130 HFALQPPTEQAC-LIPCPRDCVVSEFLPWSNCSKGCGKKLQHR------TRAVIAP---- 178
QPP+ +AC + PC S++ S CS CG +Q R + A + P
Sbjct: 825 SGPPQPPSREACDMGPCTTAWFHSDWS--SKCSAECGTGIQRRSVVCLGSGAALGPGQGE 882
Query: 179 -PLFGGLQCPNLTESRACDAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGRTVLD 237
G CP T SR D +C LG E T+ GPW +C
Sbjct: 883 AGAGTGQSCP--TGSRPPDMR-ACSLGPCERTWRWYTGPWGEC----------------- 922
Query: 238 FNSDSNERVTFKHQSYKAHHHSKSWAIEIGYQTRQVSCTRSDGQNAML---SLCLQDSFP 294
S G Q R + C G + S C P
Sbjct: 923 -----------------------SSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRP 959
Query: 295 LTVQSCIMPKDCETSQWSS-WSPCSKTCRSGS 325
+Q C + C+ +S+ WSPCS++C+ G+
Sbjct: 960 PALQPC-QGQACQDRWFSTPWSPCSRSCQGGT 990
Score = 70.1 bits (170), Expect = 2e-11
Identities = 95/384 (24%), Positives = 150/384 (39%), Gaps = 60/384 (15%)
Query: 1108 SKCPQSCDPHTMQRRTRHLLRPS---LNSRTCAEDSQV----QPCLLNENCFQFQYNLTE 1160
S C SC + + R S L+ R+CA ++ +PC C + + E
Sbjct: 674 SACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCH-GTPCPPY-WEAGE 731
Query: 1161 WSTCQLSENAPCGQGVRTRLLSC---VCSDGKPVSMDQCEQHNLEKPQRMSIPCLVECVV 1217
W++C S CG G + R L C G V ++C +L +P ++ C +
Sbjct: 732 WTSCSRS----CGPGTQHRQLQCRQEFGGGGSSVPPERCG--HLPRPN-ITQSCQLRLCG 784
Query: 1218 NCQLSGWTAWTECSQTCGHGGRMSRTRFI----IMPTQGEGRPCPTELTQEKTCPVTPCY 1273
+ ++ + W++CS CG G R + R + ++ E P + + C + PC
Sbjct: 785 HWEVG--SPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCT 842
Query: 1274 S-WVLGNWSA-CKLEGGDCGEGVQIRSLSCM-----VHSGSISHAAGRVEDALCGEMPFQ 1326
+ W +WS+ C E CG G+Q RS+ C+ + G AG + G P
Sbjct: 843 TAWFHSDWSSKCSAE---CGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPD 899
Query: 1327 DSILKQLCSVPCPGDCHLT-EW--SEWSTCELTCIDGRSFETVGRQSRSRT-FIIQSFEN 1382
+ CS+ G C T W W C C G + S+ T F + S N
Sbjct: 900 ----MRACSL---GPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSN 952
Query: 1383 QDSCPQQVLETRPCTGGKCYHYTWKASLWN---------NNERTVWCQRSDGVNVTGGCS 1433
P+ +PC G C W ++ W+ R V C S ++ C
Sbjct: 953 CSHLPRPP-ALQPCQGQACQD-RWFSTPWSPCSRSCQGGTQTREVQC-LSTNQTLSTRCP 1009
Query: 1434 PQARPAAIRQC--IPACRKPFSYC 1455
PQ RP+ R C P ++P C
Sbjct: 1010 PQLRPSRKRPCNSQPCSQRPDDQC 1033
Score = 69.3 bits (168), Expect = 3e-11
Identities = 104/407 (25%), Positives = 144/407 (35%), Gaps = 91/407 (22%)
Query: 266 IGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIM-------PKDCETSQ----WSS- 313
+G+ SC + + L + + L +SC P+ C + W +
Sbjct: 671 VGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAG 730
Query: 314 -WSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEGELLQQCPRYSW 372
W+ CS++C PG + R + GGG P E C G L
Sbjct: 731 EWTSCSRSCG-----PGTQHRQLQCRQEFGGGGSSVPP----ERC---GHLP-------- 770
Query: 373 RTSEWKECQVSLLLEQQDPHWHVTGPV------CGGGIQTREVYCAQSVPAAAALRAKEV 426
R + + CQ+ L HW V P CG G ++R+V C + EV
Sbjct: 771 RPNITQSCQLRLC-----GHWEVGSPWSQCSVRCGRGQRSRQVRCVGN-------NGDEV 818
Query: 427 SRPVEKALCVGPAPLPS-QLCNI-PCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQR 484
S E+ GP PS + C++ PC+T S WS+ C E Q +
Sbjct: 819 S---EQECASGPPQPPSREACDMGPCTTAWFHSDWSS--KCSAECGTGIQRRSVVCLGSG 873
Query: 485 HVLMESTGPAG-----HCP--------HLVESVPCEDPMCYRWLASE-GICFPDHGKCGL 530
L G AG CP PCE +RW G C +CG
Sbjct: 874 AALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCE--RTWRWYTGPWGEC---SSECGS 928
Query: 531 GHRILKAVCQNDRGED---VSGSLCP-VPPPPERKSCEIPCRMDCVLSEW--TEWSSCSQ 584
G + +C + G + S S C +P PP + PC+ W T WS CS+
Sbjct: 929 GTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQ----PCQGQACQDRWFSTPWSPCSR 984
Query: 585 SCSNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHRLCNDHSCMQ 631
SC G QTR L+ CPP R CN C Q
Sbjct: 985 SCQG----GTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPCSQ 1027
Score = 65.9 bits (159), Expect = 3e-10
Identities = 108/448 (24%), Positives = 148/448 (33%), Gaps = 122/448 (27%)
Query: 438 PAPLPSQLCNIPCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHC 497
PA ++ + CS C W LCI + G +R + PA
Sbjct: 664 PAAYWKRVGHSACSASCGKGVWRPIFLCISR-------ESGEELDERSCAAGARPPAS-- 714
Query: 498 PHLVESVPCEDPM-CYRWLASEGICFPDHGKCGLGHRILKAVCQNDRGEDVSGSLCP--- 553
P PC W + C P G HR L+ C+ + G GS P
Sbjct: 715 PEPCHGTPCPPYWEAGEWTSCSRSCGP-----GTQHRQLQ--CRQEFGG--GGSSVPPER 765
Query: 554 ---VPPPPERKSCEIPCRMDCVLSEW---TEWSSCSQSCSNKNSDGKQTRSRTILALAGE 607
+P P +SC++ + W + WS CS C G+ RSR + +
Sbjct: 766 CGHLPRPNITQSCQLR-----LCGHWEVGSPWSQCSVRC------GRGQRSRQVRCVGNN 814
Query: 608 G----------GKPCPPSQALQEHRLCNDHSCMQLHWETSPWGP-CSEDTLVTALNATIG 656
G G P PPS+ C+ C W S W CS
Sbjct: 815 GDEVSEQECASGPPQPPSR-----EACDMGPCTTA-WFHSDWSSKCS------------- 855
Query: 657 WNGEATCGVGIQTRRVFCVKS---------HVGQVMTKRCPDSTRPETVRPCFL-PCKKD 706
A CG GIQ R V C+ S G + CP +RP +R C L PC++
Sbjct: 856 ----AECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCERT 911
Query: 707 CIVTAFSEWTPCPRMCQAGNATVKQSRYRIIIQEAAN-----GGQEC-----PDTLY--E 754
W C C +G Q R I + + C P L +
Sbjct: 912 WRWYT-GPWGECSSECGSGT----QRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQ 966
Query: 755 ERECEDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCIS-DDNRS 813
+ C+D RW WSPC S +C G QTR V C+S + S
Sbjct: 967 GQACQD-------RWFSTPWSPC--------------SRSCQGGTQTREVQCLSTNQTLS 1005
Query: 814 AEMMECLKQTNGMPLLVQECTVPCREDC 841
L+ + P Q C+ + C
Sbjct: 1006 TRCPPQLRPSRKRPCNSQPCSQRPDDQC 1033
Score = 50.1 bits (118), Expect = 2e-05
Identities = 85/376 (22%), Positives = 122/376 (32%), Gaps = 84/376 (22%)
Query: 106 GLQHRMVRCIQKLNRTVVANEICEHFALQPPTEQACL-IPCPRDCVVSEFLPWSNCSKGC 164
G+ + CI + + + C A P + + C PCP E W++CS+ C
Sbjct: 683 GVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGE---WTSCSRSC 739
Query: 165 GKKLQHRT----------RAVIAPPLFGGLQCPNLTESRACDAPISCPLGEEEYTFSLKV 214
G QHR + + P G L PN+T+ SC L +V
Sbjct: 740 GPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQ--------SCQL---RLCGHWEV 788
Query: 215 G-PWSKC--------RLPHLKEINPSGRTVLDFNSDSNERVTFKHQSYKAHHHSKSW--- 262
G PWS+C R ++ + +G V + S ++ + +W
Sbjct: 789 GSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHS 848
Query: 263 --------AIEIGYQTRQVSCTRS-----DGQN----AMLSLCLQDSFPLTVQSCIMPKD 305
G Q R V C S GQ C S P +++C +
Sbjct: 849 DWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPC 908
Query: 306 CETSQW--SSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEGEL 363
T +W W CS C SG+ S+ + C L A
Sbjct: 909 ERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPA------- 961
Query: 364 LQQCPRYS----WRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAA 419
LQ C + W ++ W C S C GG QTREV C S
Sbjct: 962 LQPCQGQACQDRWFSTPWSPCSRS----------------CQGGTQTREVQCL-STNQTL 1004
Query: 420 ALRAKEVSRPVEKALC 435
+ R RP K C
Sbjct: 1005 STRCPPQLRPSRKRPC 1020
Score = 47.8 bits (112), Expect = 9e-05
Identities = 45/180 (25%), Positives = 69/180 (38%), Gaps = 35/180 (19%)
Query: 20 RCTGDCGPGGVQSRAVWCF---------HVDGWTSHLSNCGESNRPPKERSC-FRVCDWH 69
+C+ +CG G +Q R+V C + +C +RPP R+C C+
Sbjct: 853 KCSAECGTG-IQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCE-- 909
Query: 70 SDLFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNR--TVVANEI 127
++W W C ++EC + G Q R + C+ KL V +
Sbjct: 910 -RTWRWYTGPWGEC-------------SSECGS---GTQRRDIICVSKLGTEFNVTSPSN 952
Query: 128 CEHFALQPPTEQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCP 187
C H +PP Q C +D S PWS CS+ C Q R ++ +CP
Sbjct: 953 CSHLP-RPPALQPCQGQACQDRWFST--PWSPCSRSCQGGTQTREVQCLSTNQTLSTRCP 1009
Score = 42.7 bits (99), Expect = 0.003
Identities = 45/168 (26%), Positives = 60/168 (35%), Gaps = 30/168 (17%)
Query: 13 KLAGPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFRVCDWHSDL 72
++ PW +C+ CG G +SR V C +G C P R CD
Sbjct: 787 EVGSPWSQCSVRCGRGQ-RSRQVRCVGNNGDEVSEQECASGPPQPPSREA---CDMGPCT 842
Query: 73 FQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQ--------KLNRTVVA 124
W SDW +AEC T G+Q R V C+ +
Sbjct: 843 TAWFHSDWS------------SKCSAECGT---GIQRRSVVCLGSGAALGPGQGEAGAGT 887
Query: 125 NEICEHFALQPPTEQACLI-PCPRDCVVSEFLPWSNCSKGCGKKLQHR 171
+ C + +PP +AC + PC R PW CS CG Q R
Sbjct: 888 GQSCPTGS-RPPDMRACSLGPCERTWRWYTG-PWGECSSECGSGTQRR 933
Score = 42.7 bits (99), Expect = 0.003
Identities = 39/164 (23%), Positives = 64/164 (39%), Gaps = 23/164 (14%)
Query: 16 GPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHL---SNCGESNRPPKERSCFRVCDWHSDL 72
GPWG C+ +CG G Q R + C G ++ SNC RPP + C +
Sbjct: 917 GPWGECSSECG-SGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPP----ALQPCQGQACQ 971
Query: 73 FQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHFA 132
+W + W C +G + R +C++ L R ++ + ++ C
Sbjct: 972 DRWFSTPWSPC--SRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPCS--- 1026
Query: 133 LQPPTEQA------C-LIPCPRDCVVSEFLPWSNCSKGCGKKLQ 169
Q P +Q C L+ R CV + + C + C L+
Sbjct: 1027 -QRPDDQCKDSSPHCPLVVQARLCVYPYYT--ATCCRSCAHVLE 1067
Score = 32.7 bits (73), Expect = 2.8
Identities = 11/20 (55%), Positives = 14/20 (70%)
Query: 975 WSSWGSCSSSCGIGVRIRSK 994
W W SCS CG+GV+ RS+
Sbjct: 50 WVQWASCSQPCGVGVQRRSR 69
>gi|115387099 brain-specific angiogenesis inhibitor 2 [Homo sapiens]
Length = 1585
Score = 86.7 bits (213), Expect = 2e-16
Identities = 80/295 (27%), Positives = 115/295 (38%), Gaps = 52/295 (17%)
Query: 1161 WSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHNLEKPQRMSIPC--LVECVVN 1218
WS C L+ CGQG++ R SCV S + P R + PC C V+
Sbjct: 318 WSVCSLT----CGQGLQVRTRSCVSSPYGTLCSG---------PLRETRPCNNSATCPVH 364
Query: 1219 CQLSGWTAWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPTELTQEKTCPVTPC---YSW 1275
W +W+ CS++CG G R SR R + P G G+ C Q K C + C W
Sbjct: 365 GVWEEWGSWSLCSRSCGRGSR-SRMRTCVPPQHG-GKACEGPELQTKLCSMAACPVEGQW 422
Query: 1276 V-LGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSILKQLC 1334
+ G W C C G Q RS C V + + G + D ++
Sbjct: 423 LEWGPWGPCST---SCANGTQQRSRKCSVAGPAWATCTGALTDT------------RECS 467
Query: 1335 SVPCPG-DCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQSFENQD-SCPQQVLE 1392
++ CP D W+ WS C TC G Q R R + Q+ Q C E
Sbjct: 468 NLECPATDSKWGPWNAWSLCSKTC-------DTGWQRRFR--MCQATGTQGYPCEGTGEE 518
Query: 1393 TRPCTGGKC--YHYTWKASLWNNNERTVWCQRSDGVNVTGGCSPQARPAAIRQCI 1445
+PC+ +C +H + W + + G + C P A +A R+C+
Sbjct: 519 VKPCSEKRCPAFHEMCRDEY---VMLMTWKKAAAGEIIYNKCPPNASGSASRRCL 570
Score = 72.4 bits (176), Expect = 3e-12
Identities = 77/308 (25%), Positives = 102/308 (33%), Gaps = 93/308 (30%)
Query: 969 DCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHEAVPCYSEC 1028
D +WS W CS +CG G+++R++ PY G C + E PC +
Sbjct: 309 DPAAEEWSPWSVCSLTCGQGLQVRTRSCVSSPY--GTLC-------SGPLRETRPCNNSA 359
Query: 1029 N-QYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPE 1087
V E W S L S CG G++SR CV G C E+ +
Sbjct: 360 TCPVHGVWEEWGSW----SLCSRSCGRGSRSRMRTCVPPQHG------GKACEGPEL--Q 407
Query: 1088 TQSCSL-MCPNECVMSEWGLWSKCPQSCDPHTMQRRTRHLLRPSLNSRTCAEDSQVQPCL 1146
T+ CS+ CP E EWG W C SC T QR SR C+
Sbjct: 408 TKLCSMAACPVEGQWLEWGPWGPCSTSCANGTQQR-----------SRKCSVAGPA---- 452
Query: 1147 LNENCFQFQYNLTEWSTC--QLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHNLEKP 1204
W+TC L++ C L C +D K
Sbjct: 453 --------------WATCTGALTDTRECSN------LECPATDSK--------------- 477
Query: 1205 QRMSIPCLVECVVNCQLSGWTAWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPTELTQE 1264
W AW+ CS+TC G R + T +G PC +
Sbjct: 478 ----------------WGPWNAWSLCSKTCDTG--WQRRFRMCQATGTQGYPCEGTGEEV 519
Query: 1265 KTCPVTPC 1272
K C C
Sbjct: 520 KPCSEKRC 527
Score = 68.6 bits (166), Expect = 5e-11
Identities = 65/227 (28%), Positives = 86/227 (37%), Gaps = 32/227 (14%)
Query: 925 SKECGEGLRFRAVAC-SDKNGRPVDPSFCSSSGYIQEKC--VIPCPFDCKLSDWSSWGSC 981
S CG+GL+ R +C S G + CS C CP +W SW C
Sbjct: 322 SLTCGQGLQVRTRSCVSSPYG-----TLCSGPLRETRPCNNSATCPVHGVWEEWGSWSLC 376
Query: 982 SSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHEAVPCYSECNQYSWVVEHWSSC 1041
S SCG G R R + P +GG+ C +L Q ++ C E W W C
Sbjct: 377 SRSCGRGSRSRMRTCVP-PQHGGKACEGPEL--QTKLCSMAACPVEGQWLEW--GPWGPC 431
Query: 1042 KINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQSCS-LMCP-NEC 1099
S C GTQ R +C + G A + +T+ CS L CP +
Sbjct: 432 -------STSCANGTQQRSRKC--SVAGPAWATCTGALT------DTRECSNLECPATDS 476
Query: 1100 VMSEWGLWSKCPQSCDPHTMQRRTRHLLRPSLNSRTC-AEDSQVQPC 1145
W WS C ++CD QRR R C +V+PC
Sbjct: 477 KWGPWNAWSLCSKTCDT-GWQRRFRMCQATGTQGYPCEGTGEEVKPC 522
Score = 64.3 bits (155), Expect = 9e-10
Identities = 63/246 (25%), Positives = 91/246 (36%), Gaps = 58/246 (23%)
Query: 1224 WTAWTECSQTCGHGGRMSRTRFIIMPTQG--------EGRPCPTELTQEKTCPVTPCY-S 1274
W+ W+ CS TCG G ++ RTR + G E RPC TCPV +
Sbjct: 315 WSPWSVCSLTCGQGLQV-RTRSCVSSPYGTLCSGPLRETRPC----NNSATCPVHGVWEE 369
Query: 1275 WVLGNWSACKLEGGDCGEGVQIRSLSCM--VHSGSISHAAGRVEDALCGEMPFQDSILKQ 1332
W G+WS C CG G + R +C+ H G + +
Sbjct: 370 W--GSWSLC---SRSCGRGSRSRMRTCVPPQHGGKACEG---------------PELQTK 409
Query: 1333 LCSV-PCPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQSFENQDSCPQQVL 1391
LCS+ CP + EW W C +C + G Q RSR + +C +
Sbjct: 410 LCSMAACPVEGQWLEWGPWGPCSTSCAN-------GTQQRSRKCSVAG-PAWATCTGALT 461
Query: 1392 ETRPCTGGKCYHYTWKASLWN------NNERTVWCQRSDGVNVTG-------GCSPQARP 1438
+TR C+ +C K WN T W +R TG G + +P
Sbjct: 462 DTRECSNLECPATDSKWGPWNAWSLCSKTCDTGWQRRFRMCQATGTQGYPCEGTGEEVKP 521
Query: 1439 AAIRQC 1444
+ ++C
Sbjct: 522 CSEKRC 527
Score = 63.2 bits (152), Expect = 2e-09
Identities = 75/257 (29%), Positives = 99/257 (38%), Gaps = 69/257 (26%)
Query: 267 GYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCETSQWSSWSPCSKTCRSGSL 326
G Q R SC S + S L+++ P S P +W SWS CS++C GS
Sbjct: 328 GLQVRTRSCVSSP-YGTLCSGPLRETRPCN-NSATCPVHGVWEEWGSWSLCSRSCGRGS- 384
Query: 327 LPGFRSRSRNV---KHMAIGGGKEC--PELLEK----EACIVEGELLQQCPRYSWRTSEW 377
RSR R +H GGK C PEL K AC VEG+ L+ P W
Sbjct: 385 ----RSRMRTCVPPQH----GGKACEGPELQTKLCSMAACPVEGQWLEWGP--------W 428
Query: 378 KECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKALCVG 437
C S C G Q R C+ + PA A C G
Sbjct: 429 GPCSTS----------------CANGTQQRSRKCSVAGPAWAT--------------CTG 458
Query: 438 PAPLPSQLCNIPC-STDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGH 496
+ N+ C +TD W+AW LC + C D ++ FR + ++TG G+
Sbjct: 459 ALTDTRECSNLECPATDSKWGPWNAWSLC-SKTC-DTGWQRRFR------MCQATGTQGY 510
Query: 497 -CPHLVESV-PCEDPMC 511
C E V PC + C
Sbjct: 511 PCEGTGEEVKPCSEKRC 527
Score = 59.3 bits (142), Expect = 3e-08
Identities = 77/313 (24%), Positives = 114/313 (36%), Gaps = 60/313 (19%)
Query: 570 DCVLSEWTEWSSCSQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHRLCNDHSC 629
D EW+ WS CS +C G Q R+R+ ++ G C S L+E R CN+ +
Sbjct: 309 DPAAEEWSPWSVCSLTC----GQGLQVRTRS--CVSSPYGTLC--SGPLRETRPCNNSAT 360
Query: 630 MQLH--WET-SPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKR 686
+H WE W CS +CG G ++R CV G K
Sbjct: 361 CPVHGVWEEWGSWSLCSR-----------------SCGRGSRSRMRTCVPPQHG---GKA 400
Query: 687 CPDSTRPETVRPCFLPCKKDCIVTAFSEWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQ 746
C + +T C + + W PC C N T ++SR + A
Sbjct: 401 C-EGPELQTKLCSMAACPVEGQWLEWGPWGPCSTSC--ANGTQQRSRKCSV---AGPAWA 454
Query: 747 ECPDTLYEERECEDVSLCPV--YRWKP-QKWSPCILVPESVWQGITGSSEACGKGLQTRA 803
C L + REC ++ CP +W P WS C ++ WQ +A G T+
Sbjct: 455 TCTGALTDTRECSNLE-CPATDSKWGPWNAWSLCSKTCDTGWQRRFRMCQATG----TQG 509
Query: 804 VSCISDDNRSAEMMECLKQTNGMPLLVQECTVPCREDCTFTAWSK-------FTPCSTNC 856
C + E+ C ++ P + C E W K + C N
Sbjct: 510 YPC---EGTGEEVKPCSEKR--CPAFHEMCR---DEYVMLMTWKKAAAGEIIYNKCPPNA 561
Query: 857 EATKSRRRQLTGK 869
+ SRR L+ +
Sbjct: 562 SGSASRRCLLSAQ 574
Score = 58.5 bits (140), Expect = 5e-08
Identities = 63/248 (25%), Positives = 95/248 (38%), Gaps = 50/248 (20%)
Query: 528 CGLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSCE--IPCRMDCVLSEWTEWSSCSQS 585
CG G ++ C + G+LC P E + C C + V EW WS CS+S
Sbjct: 325 CGQGLQVRTRSCVSSP----YGTLCS-GPLRETRPCNNSATCPVHGVWEEWGSWSLCSRS 379
Query: 586 CSNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHRLCNDHSC-MQLHW-ETSPWGPCS 643
C G ++R RT + GGK C + + +LC+ +C ++ W E PWGPCS
Sbjct: 380 CGR----GSRSRMRTCVP-PQHGGKACEGPEL--QTKLCSMAACPVEGQWLEWGPWGPCS 432
Query: 644 ----EDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPETVRPC 699
T + ++ ATC + T+ C + P T
Sbjct: 433 TSCANGTQQRSRKCSVAGPAWATCTGALTD--------------TRECSNLECPAT---- 474
Query: 700 FLPCKKDCIVTAFSEWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQECPDTLYEERECE 759
D ++ W+ C + C G Q R+R + Q G C T E + C
Sbjct: 475 ------DSKWGPWNAWSLCSKTCDTG----WQRRFR-MCQATGTQGYPCEGTGEEVKPCS 523
Query: 760 DVSLCPVY 767
+ CP +
Sbjct: 524 E-KRCPAF 530
Score = 54.3 bits (129), Expect = 9e-07
Identities = 53/194 (27%), Positives = 78/194 (40%), Gaps = 25/194 (12%)
Query: 148 DCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPNLTESRACDAPISCPLGE-- 205
D E+ PWS CS CG+ LQ RTR+ ++ P +G L L E+R C+ +CP+
Sbjct: 309 DPAAEEWSPWSVCSLTCGQGLQVRTRSCVSSP-YGTLCSGPLRETRPCNNSATCPVHGVW 367
Query: 206 EEYTFSLKVGPWSKCRLPHLKEINPSGRTVL----DFNSDSNERVTFKHQSYKAHHHSKS 261
EE+ G WS C + RT + + + K S A
Sbjct: 368 EEW------GSWSLCSRSCGRGSRSRMRTCVPPQHGGKACEGPELQTKLCSMAACPVEGQ 421
Query: 262 W-----------AIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCETSQ 310
W + G Q R C+ + A + L D+ + C D +
Sbjct: 422 WLEWGPWGPCSTSCANGTQQRSRKCSVAGPAWATCTGALTDTRECSNLEC-PATDSKWGP 480
Query: 311 WSSWSPCSKTCRSG 324
W++WS CSKTC +G
Sbjct: 481 WNAWSLCSKTCDTG 494
Score = 53.1 bits (126), Expect = 2e-06
Identities = 63/299 (21%), Positives = 110/299 (36%), Gaps = 52/299 (17%)
Query: 785 WQGITGSSEACGKGLQTRAVSCISDDNRSAEMMECLKQTNGMPLLVQECTVPCREDCT-- 842
W + S CG+GLQ R SC+S + L++T PC T
Sbjct: 315 WSPWSVCSLTCGQGLQVRTRSCVSSPYGTL-CSGPLRETR-----------PCNNSATCP 362
Query: 843 ----FTAWSKFTPCSTNC-EATKSRRRQLTGKSRKKEKCQDSDLY-PLVETELCPCD-EF 895
+ W ++ CS +C ++SR R + C+ +L L CP + ++
Sbjct: 363 VHGVWEEWGSWSLCSRSCGRGSRSRMRTCVPPQHGGKACEGPELQTKLCSMAACPVEGQW 422
Query: 896 ISQPYGNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSDKNGRPVDPSFCSSS 955
+ +G W C S C G + R+ CS P++ + +
Sbjct: 423 LE--WGPWGPC------------------STSCANGTQQRSRKCS-----VAGPAWATCT 457
Query: 956 GYI---QEKCVIPCP-FDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLD 1011
G + +E + CP D K W++W CS +C G + R + + + G PC
Sbjct: 458 GALTDTRECSNLECPATDSKWGPWNAWSLCSKTCDTGWQRRFR-MCQATGTQGYPCEGTG 516
Query: 1012 LKNQAQVHEAVPCYSE-CNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADG 1069
+ + + P + E C ++ W + + + S RC+ +A G
Sbjct: 517 EEVKPCSEKRCPAFHEMCRDEYVMLMTWKKAAAGEIIYNKCPPNASGSASRRCLLSAQG 575
Score = 52.0 bits (123), Expect = 5e-06
Identities = 70/267 (26%), Positives = 93/267 (34%), Gaps = 53/267 (19%)
Query: 393 WHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKALCVGPAPLPSQLCN--IPC 450
W V CG G+Q R C VS P LC GP ++ CN C
Sbjct: 318 WSVCSLTCGQGLQVRTRSC--------------VSSPYG-TLCSGPLR-ETRPCNNSATC 361
Query: 451 STDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRH-VLMESTGPAGHCPHLVESVPCEDP 509
+ W +W LC +C +G R+R R V + G A P L + C
Sbjct: 362 PVHGVWEEWGSWSLC-SRSCG-----RGSRSRMRTCVPPQHGGKACEGPELQTKL-CSMA 414
Query: 510 MCY---RWLASEGICFPDHGKCGLGHRILKAVCQNDRGEDVSG---SLCPVPPPPERKSC 563
C +WL G P C G + Q R V+G + C R+
Sbjct: 415 ACPVEGQWL-EWGPWGPCSTSCANGTQ------QRSRKCSVAGPAWATCTGALTDTRECS 467
Query: 564 EIPC-RMDCVLSEWTEWSSCSQSCSNKNSDGKQTRSRTILALA---------GEGGKPCP 613
+ C D W WS CS++C G Q R R A GE KPC
Sbjct: 468 NLECPATDSKWGPWNAWSLCSKTCDT----GWQRRFRMCQATGTQGYPCEGTGEEVKPCS 523
Query: 614 PSQALQEHRLCNDHSCMQLHWETSPWG 640
+ H +C D M + W+ + G
Sbjct: 524 EKRCPAFHEMCRDEYVMLMTWKKAAAG 550
Score = 47.0 bits (110), Expect = 1e-04
Identities = 58/225 (25%), Positives = 84/225 (37%), Gaps = 48/225 (21%)
Query: 4 TADEVVLYHKLAG--------PWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNR 55
+ADE LY G PW C+ CG G +Q R C + + + C R
Sbjct: 296 SADEPGLYMAQTGDPAAEEWSPWSVCSLTCGQG-LQVRTRSCVS----SPYGTLCSGPLR 350
Query: 56 PPKERSCFRVCDWHSDLFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCI 115
+ + C H +W W C RG + R CV QHG
Sbjct: 351 ETRPCNNSATCPVHGVWEEW--GSWSLCSR-SCGRGS-RSRMRTCVPPQHG--------- 397
Query: 116 QKLNRTVVANEICEHFALQPPTEQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTR-A 174
+ CE LQ T+ + CP + E+ PW CS C Q R+R
Sbjct: 398 ---------GKACEGPELQ--TKLCSMAACPVEGQWLEWGPWGPCSTSCANGTQQRSRKC 446
Query: 175 VIAPPLFGGLQCPN-LTESRACDAPISCPLGEEEYTFSLKVGPWS 218
+A P + C LT++R C + + CP + ++ GPW+
Sbjct: 447 SVAGPAWA--TCTGALTDTREC-SNLECPATDSKW------GPWN 482
Score = 38.1 bits (87), Expect = 0.068
Identities = 35/122 (28%), Positives = 46/122 (37%), Gaps = 35/122 (28%)
Query: 1340 GDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQSFENQDSCPQQVLETRPCTGG 1399
GD EWS WS C LTC G Q R+R+ + + C + ETRPC
Sbjct: 308 GDPAAEEWSPWSVCSLTC-------GQGLQVRTRSCVSSPYGT--LCSGPLRETRPCNNS 358
Query: 1400 KC--YHYTWKASLWNNNERTVW--CQRSDGVNVTGGCSPQARPAAIRQCIP------ACR 1449
H W+ W + W C RS G + + +R C+P AC
Sbjct: 359 ATCPVHGVWEE--WGS-----WSLCSRSCG---------RGSRSRMRTCVPPQHGGKACE 402
Query: 1450 KP 1451
P
Sbjct: 403 GP 404
>gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens]
Length = 1522
Score = 80.1 bits (196), Expect = 2e-14
Identities = 86/315 (27%), Positives = 123/315 (39%), Gaps = 76/315 (24%)
Query: 573 LSEWTEWSSCSQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHRLCNDHSCMQL 632
+ EW++WS+CS +C G Q R+RT ++ G C S L+E R+CN+ + +
Sbjct: 294 VEEWSQWSTCSVTC----GQGSQVRTRTCVS---PYGTHC--SGPLRESRVCNNTALCPV 344
Query: 633 H--WET-SPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPD 689
H WE SPW CS TCG G +TR C G + C
Sbjct: 345 HGVWEEWSPWSLCS-----------------FTCGRGQRTRTRSCTPPQYG---GRPCEG 384
Query: 690 STRPET-VRPCFLP-CKKDCIVTAFSEWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQE 747
PET +PC + C D +S W+ C C N T ++SR AA+GG E
Sbjct: 385 ---PETHHKPCNIALCPVDGQWQEWSSWSQCSVTC--SNGTQQRSRQ---CTAAAHGGSE 436
Query: 748 CPDTLYEERECEDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCI 807
C E REC + +W + W +G S++C G + R +C
Sbjct: 437 CRGPWAESRECYNPECTANGQW-------------NQWGHWSGCSKSCDGGWERRIRTCQ 483
Query: 808 SD-------DNRSAEMMECLKQTNGMPLLVQECTVPCREDCTFT-AWSK-------FTPC 852
+ E+ C +Q P + C ED + W + F C
Sbjct: 484 GAVITGQQCEGTGEEVRRCSEQRCPAPYEI------CPEDYLMSMVWKRTPAGDLAFNQC 537
Query: 853 STNCEATKSRRRQLT 867
N T SRR L+
Sbjct: 538 PLNATGTTSRRCSLS 552
Score = 79.3 bits (194), Expect = 3e-14
Identities = 73/251 (29%), Positives = 98/251 (39%), Gaps = 49/251 (19%)
Query: 1159 TEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHNLEKPQRMSIPC--LVECV 1216
++WSTC ++ CGQG + R +CV G S P R S C C
Sbjct: 298 SQWSTCSVT----CGQGSQVRTRTCVSPYGTHCS----------GPLRESRVCNNTALCP 343
Query: 1217 VNCQLSGWTAWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPTELTQEKTCPVTPC---- 1272
V+ W+ W+ CS TCG G R +RTR P G GRPC T K C + C
Sbjct: 344 VHGVWEEWSPWSLCSFTCGRGQR-TRTRSCTPPQYG-GRPCEGPETHHKPCNIALCPVDG 401
Query: 1273 --YSWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSIL 1330
W +WS C + C G Q RS C + S G P+ +S
Sbjct: 402 QWQEW--SSWSQCSVT---CSNGTQQRSRQCTAAAHGGSECRG----------PWAES-- 444
Query: 1331 KQLCSVPCPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQSFENQDSCPQQV 1390
++ + C + +W WS C +C DG G + R RT Q C
Sbjct: 445 RECYNPECTANGQWNQWGHWSGCSKSC-DG------GWERRIRTCQGAVITGQ-QCEGTG 496
Query: 1391 LETRPCTGGKC 1401
E R C+ +C
Sbjct: 497 EEVRRCSEQRC 507
Score = 66.6 bits (161), Expect = 2e-10
Identities = 72/278 (25%), Positives = 103/278 (37%), Gaps = 64/278 (23%)
Query: 709 VTAFSEWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQECPDTLYEERECEDVSLCPVYR 768
V +S+W+ C C G+ Q R R + G C L E R C + +LCPV+
Sbjct: 294 VEEWSQWSTCSVTCGQGS----QVRTRTCVSPY---GTHCSGPLRESRVCNNTALCPVHG 346
Query: 769 -WKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCISDD--NRSAEMMECLKQTNG 825
W ++WSP L S CG+G +TR SC R E E T+
Sbjct: 347 VW--EEWSPWSL-----------CSFTCGRGQRTRTRSCTPPQYGGRPCEGPE----THH 389
Query: 826 MPLLVQECTVPCREDCTFTAWSKFTPCSTNC-EATKSRRRQLTGKSRKKEKCQDSDLYPL 884
P + C V D + WS ++ CS C T+ R RQ T + +C+ P
Sbjct: 390 KPCNIALCPV----DGQWQEWSSWSQCSVTCSNGTQQRSRQCTAAAHGGSECRG----PW 441
Query: 885 VETELCPCDEFIS----QPYGNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACS 940
E+ C E + +G+WS C SK C G R C
Sbjct: 442 AESRECYNPECTANGQWNQWGHWSGC------------------SKSCDGGWERRIRTC- 482
Query: 941 DKNGRPVDPSFCSSSGYIQEKCV---IPCPFDCKLSDW 975
G + C +G +C P P++ D+
Sbjct: 483 --QGAVITGQQCEGTGEEVRRCSEQRCPAPYEICPEDY 518
Score = 66.6 bits (161), Expect = 2e-10
Identities = 68/282 (24%), Positives = 106/282 (37%), Gaps = 66/282 (23%)
Query: 846 WSKFTPCSTNC-EATKSRRR--------QLTGKSRKKEKCQDSDLYPLVETELCPCDEFI 896
WS+++ CS C + ++ R R +G R+ C + T LCP +
Sbjct: 297 WSQWSTCSVTCGQGSQVRTRTCVSPYGTHCSGPLRESRVCNN--------TALCPVHG-V 347
Query: 897 SQPYGNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSDKN--GRPVDPSFCSS 954
+ + WS C S CG G R R +C+ GRP C
Sbjct: 348 WEEWSPWSLC------------------SFTCGRGQRTRTRSCTPPQYGGRP-----CEG 384
Query: 955 SGYIQEKCVIP-CPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLK 1013
+ C I CP D + +WSSW CS +C G + RS+ + GG C +
Sbjct: 385 PETHHKPCNIALCPVDGQWQEWSSWSQCSVTCSNGTQQRSRQCTAAAH-GGSECRGPWAE 443
Query: 1014 NQAQVHEAVPCYSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRC----VNTADG 1069
++ + + NQ+ HWS C S C GG + R C +
Sbjct: 444 SRECYNPECTANGQWNQWG----HWSGC-------SKSCDGGWERRIRTCQGAVITGQQC 492
Query: 1070 EGGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEWGLWSKCP 1111
EG + C++ P + +CP + +MS +W + P
Sbjct: 493 EGTGEEVRRCSEQRCPAPYE----ICPEDYLMSM--VWKRTP 528
Score = 63.2 bits (152), Expect = 2e-09
Identities = 72/262 (27%), Positives = 101/262 (38%), Gaps = 53/262 (20%)
Query: 1098 ECVMSEWGLWSKCPQSCDPHTMQRRTR--------HLLRPSLNSRTCAEDSQVQPCLLNE 1149
E + EW WS C +C + Q RTR H P SR C + C ++
Sbjct: 291 ESGVEEWSQWSTCSVTCGQGS-QVRTRTCVSPYGTHCSGPLRESRVC---NNTALCPVHG 346
Query: 1150 NCFQFQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSD--GKPVSMDQCEQHNLEKPQRM 1207
++ + WS C + CG+G RTR SC G+P E P+
Sbjct: 347 VWEEW----SPWSLCSFT----CGRGQRTRTRSCTPPQYGGRPC----------EGPETH 388
Query: 1208 SIPCLVE-CVVNCQLSGWTAWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPTELTQEKT 1266
PC + C V+ Q W++W++CS TC + G R+R G G C + +
Sbjct: 389 HKPCNIALCPVDGQWQEWSSWSQCSVTCSN-GTQQRSRQCTAAAHG-GSECRGPWAESRE 446
Query: 1267 CPVTPCYS---W-VLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGE 1322
C C + W G+WS C + D G +IR+ V +G G E C E
Sbjct: 447 CYNPECTANGQWNQWGHWSGCS-KSCDGGWERRIRTCQGAVITGQQCEGTGE-EVRRCSE 504
Query: 1323 MPFQDSILKQLCSVP---CPGD 1341
Q C P CP D
Sbjct: 505 ---------QRCPAPYEICPED 517
Score = 63.2 bits (152), Expect = 2e-09
Identities = 71/265 (26%), Positives = 99/265 (37%), Gaps = 52/265 (19%)
Query: 528 CGLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSCEIP--CRMDCVLSEWTEWSSCSQS 585
CG G ++ C + G SG P E + C C + V EW+ WS CS +
Sbjct: 307 CGQGSQVRTRTCVSPYGTHCSG------PLRESRVCNNTALCPVHGVWEEWSPWSLCSFT 360
Query: 586 CSNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHRLCNDHSC-MQLHW-ETSPWGPCS 643
C G++TR+R+ GG+PC + H+ CN C + W E S W CS
Sbjct: 361 CGR----GQRTRTRSCTP-PQYGGRPCEGPET--HHKPCNIALCPVDGQWQEWSSWSQCS 413
Query: 644 EDTLVTALNATIGWNGEATCGVGIQTRRVFC-VKSHVGQVMTKRCPDSTRPETVRPCFLP 702
TC G Q R C +H G +S R C+ P
Sbjct: 414 -----------------VTCSNGTQQRSRQCTAAAHGGSECRGPWAES------RECYNP 450
Query: 703 -CKKDCIVTAFSEWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQECPDTLYEERECEDV 761
C + + W+ C + C G + R R Q A GQ+C T E R C +
Sbjct: 451 ECTANGQWNQWGHWSGCSKSCDGG----WERRIR-TCQGAVITGQQCEGTGEEVRRCSE- 504
Query: 762 SLCPVYRWKPQKWSPCILVPESVWQ 786
CP P + P + VW+
Sbjct: 505 QRCPA----PYEICPEDYLMSMVWK 525
Score = 61.2 bits (147), Expect = 7e-09
Identities = 52/182 (28%), Positives = 71/182 (39%), Gaps = 30/182 (16%)
Query: 1224 WTAWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPTELTQEKTCPVT---PCYSWVLGNW 1280
W+ W+ CS TCG G ++ RTR + P G C L + + C T P + V W
Sbjct: 297 WSQWSTCSVTCGQGSQV-RTRTCVSPY---GTHCSGPLRESRVCNNTALCPVHG-VWEEW 351
Query: 1281 SACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSILKQLCSVP-CP 1339
S L CG G + R+ SC + E P C++ CP
Sbjct: 352 SPWSLCSFTCGRGQRTRTRSCTPPQ----YGGRPCEGPETHHKP---------CNIALCP 398
Query: 1340 GDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQSFENQDSCPQQVLETRPCTGG 1399
D EWS WS C +TC + G Q RSR + + C E+R C
Sbjct: 399 VDGQWQEWSSWSQCSVTCSN-------GTQQRSRQCTAAAHGGSE-CRGPWAESRECYNP 450
Query: 1400 KC 1401
+C
Sbjct: 451 EC 452
Score = 58.9 bits (141), Expect = 4e-08
Identities = 58/231 (25%), Positives = 83/231 (35%), Gaps = 36/231 (15%)
Query: 972 LSDWSSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHEAVPCYSECNQY 1031
+ +WS W +CS +CG G ++R++ PY G C L+ + C
Sbjct: 294 VEEWSQWSTCSVTCGQGSQVRTRTC-VSPY--GTHCSG-PLRESRVCNNTALCPVHGVWE 349
Query: 1032 SWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADG----EGGAVDSNLCNQDEIPPE 1087
W WS C S CG G ++R C G EG CN
Sbjct: 350 EW--SPWSLC-------SFTCGRGQRTRTRSCTPPQYGGRPCEGPETHHKPCN------- 393
Query: 1088 TQSCSLMCPNECVMSEWGLWSKCPQSCDPHTMQRRTRHLLRPSLNSRTCAEDSQVQPCLL 1147
+CP + EW WS+C +C T QR + S ++ + C
Sbjct: 394 ----IALCPVDGQWQEWSSWSQCSVTCSNGTQQRSRQCTAAAHGGSECRGPWAESRECYN 449
Query: 1148 NENCFQFQYN-LTEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCE 1197
E Q+N WS C S C G R+ +C G ++ QCE
Sbjct: 450 PECTANGQWNQWGHWSGCSKS----CDGGWERRIRTC---QGAVITGQQCE 493
Score = 58.2 bits (139), Expect = 6e-08
Identities = 75/301 (24%), Positives = 100/301 (33%), Gaps = 85/301 (28%)
Query: 151 VSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPN-LTESRACDAPISCPLGE--EE 207
V E+ WS CS CG+ Q RTR ++P G C L ESR C+ CP+ EE
Sbjct: 294 VEEWSQWSTCSVTCGQGSQVRTRTCVSP---YGTHCSGPLRESRVCNNTALCPVHGVWEE 350
Query: 208 YTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDSNERVTFKHQSYKAHHHSKSWAIEIG 267
++ PWS C S+ G
Sbjct: 351 WS------PWSLC----------------------------------------SFTCGRG 364
Query: 268 YQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCETSQWSSWSPCSKTCRSGSLL 327
+TR SCT P + C P D + +WSSWS CS TC +G+
Sbjct: 365 QRTRTRSCTPPQYGGRPCEGPETHHKPCNIALC--PVDGQWQEWSSWSQCSVTCSNGT-- 420
Query: 328 PGFRSRSRNVKHMAIGGGKECPELLEKEACIVEGELLQQCPRYSWRTSEWKECQVSLLLE 387
+ RSR A GG + E C +C +W
Sbjct: 421 ---QQRSRQCTAAAHGGSECRGPWAESREC-----YNPECT----ANGQW---------- 458
Query: 388 QQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALR--AKEVSRPVEKALCVGPAPLPSQL 445
Q HW C GG + R C +V +EV R E+ P P ++
Sbjct: 459 NQWGHWSGCSKSCDGGWERRIRTCQGAVITGQQCEGTGEEVRRCSEQR-----CPAPYEI 513
Query: 446 C 446
C
Sbjct: 514 C 514
Score = 49.7 bits (117), Expect = 2e-05
Identities = 54/181 (29%), Positives = 68/181 (37%), Gaps = 33/181 (18%)
Query: 528 CGLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSCEIP-CRMDCVLSEWTEWSSCSQSC 586
CG G R C + G C P K C I C +D EW+ WS CS +C
Sbjct: 361 CGRGQRTRTRSCTPPQ---YGGRPCE-GPETHHKPCNIALCPVDGQWQEWSSWSQCSVTC 416
Query: 587 SNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHRLCNDHSC-MQLHW-ETSPWGPCS- 643
SN G Q RSR A A GG C A E R C + C W + W CS
Sbjct: 417 SN----GTQQRSRQCTA-AAHGGSECRGPWA--ESRECYNPECTANGQWNQWGHWSGCSK 469
Query: 644 ------EDTLVTALNATIGWNGEATCGVGIQTRRV----------FCVKSHVGQVMTKRC 687
E + T A I G+ G G + RR C + ++ ++ KR
Sbjct: 470 SCDGGWERRIRTCQGAVI--TGQQCEGTGEEVRRCSEQRCPAPYEICPEDYLMSMVWKRT 527
Query: 688 P 688
P
Sbjct: 528 P 528
Score = 44.7 bits (104), Expect = 7e-04
Identities = 58/253 (22%), Positives = 85/253 (33%), Gaps = 78/253 (30%)
Query: 76 EVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHFALQP 135
E S W C + +V+ RT H C L + +C + AL
Sbjct: 296 EWSQWSTCSVTCGQGSQVRTRTCVSPYGTH--------CSGPLRES----RVCNNTAL-- 341
Query: 136 PTEQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPN-LTESRA 194
CP V E+ PWS CS CG+ + RTR+ PP +GG C T +
Sbjct: 342 ---------CPVHGVWEEWSPWSLCSFTCGRGQRTRTRS-CTPPQYGGRPCEGPETHHKP 391
Query: 195 CDAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDSNERVTFKHQSYK 254
C+ + CP+ + +S WS+C
Sbjct: 392 CNIAL-CPVDGQWQEWS----SWSQC---------------------------------- 412
Query: 255 AHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMPK---DCETSQW 311
S G Q R CT + + +S + C P+ + + +QW
Sbjct: 413 ------SVTCSNGTQQRSRQCTAAAHGGSECRGPWAES-----RECYNPECTANGQWNQW 461
Query: 312 SSWSPCSKTCRSG 324
WS CSK+C G
Sbjct: 462 GHWSGCSKSCDGG 474
Score = 39.7 bits (91), Expect = 0.023
Identities = 53/204 (25%), Positives = 69/204 (33%), Gaps = 49/204 (24%)
Query: 310 QWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECP-ELLEKEACIVEGELLQQCP 368
+WS WS CS TC GS + R+R+ + G C L E C
Sbjct: 296 EWSQWSTCSVTCGQGSQV---RTRTCVSPY-----GTHCSGPLRESRVC----------- 336
Query: 369 RYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSR 428
+ C V + E+ P W + CG G +TR C + R
Sbjct: 337 ------NNTALCPVHGVWEEWSP-WSLCSFTCGRGQRTRTRSCTP---------PQYGGR 380
Query: 429 PVEKALCVGPAPLPSQLCNIP-CSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVL 487
P C GP + CNI C D WS+W C + Q + T H
Sbjct: 381 P-----CEGP-ETHHKPCNIALCPVDGQWQEWSSWSQCSVTCSNGTQQRSRQCTAAAHGG 434
Query: 488 MESTGPAGHCPHLVESVPCEDPMC 511
E GP ES C +P C
Sbjct: 435 SECRGP------WAESRECYNPEC 452
Score = 33.9 bits (76), Expect = 1.3
Identities = 12/26 (46%), Positives = 16/26 (61%)
Query: 1340 GDCHLTEWSEWSTCELTCIDGRSFET 1365
G+ + EWS+WSTC +TC G T
Sbjct: 290 GESGVEEWSQWSTCSVTCGQGSQVRT 315
>gi|4505737 complement factor properdin precursor [Homo sapiens]
Length = 469
Score = 76.6 bits (187), Expect = 2e-13
Identities = 91/366 (24%), Positives = 135/366 (36%), Gaps = 51/366 (13%)
Query: 776 PCILVPESVWQGITGSSEACGKGLQTRAVSCISDDNR-SAEMMECLKQTNGMPLLVQECT 834
PC S+W S C +G Q R C+ + + S ++ + Q+C
Sbjct: 74 PCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQC- 132
Query: 835 VPCREDCTFTAWSKFTPCSTNC-EATKSRRRQLTGKSRKKEKCQDSDLYPLVETELCPCD 893
C E ++ W + PCS C + T++RRR + KC E+E C
Sbjct: 133 --CPEMGGWSGWGPWEPCSVTCSKGTRTRRRAC---NHPAPKCGGHCPGQAQESEACDTQ 187
Query: 894 EFIS-----QPYGNWSDCILP--EGRREPHRGLRVQADSKECGEGLRFRAVACSDK-NGR 945
+ +G W+ C G EP + S++C A S K G+
Sbjct: 188 QVCPTHGAWATWGPWTPCSASCHGGPHEPK-----ETRSRKCS------APEPSQKPPGK 236
Query: 946 PVDPSFCSSSGYIQEKC--VIPCPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEK-PYN 1002
P C Y Q +C + PCP W C +CG+G + + P +
Sbjct: 237 P-----CPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQH 291
Query: 1003 GGRPCPKLDLKNQAQVHEAVPCYSECNQYSWVVEHWSSCKINNELRSLRCG--GGTQSRK 1060
GG C D + AVPC + SW WS C I ++S+ C G QSR
Sbjct: 292 GGPFCAG-DATRTHICNTAVPCPVDGEWDSW--GEWSPC-IRRNMKSISCQEIPGQQSRG 347
Query: 1061 IRCVNTADGEGGAVDSNLCNQDEIPPETQSCSLM--CPNECVMSEWGLWSKCPQSCDPHT 1118
C G D + C + + + C + CP + SEW W C C P+
Sbjct: 348 RTC------RGRKFDGHRCAGQQ--QDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNP 399
Query: 1119 MQRRTR 1124
+ R R
Sbjct: 400 TRARQR 405
Score = 75.9 bits (185), Expect = 3e-13
Identities = 103/378 (27%), Positives = 135/378 (35%), Gaps = 66/378 (17%)
Query: 288 CLQDSFPLTVQSCIMPKDCET---SQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGG 344
CL +F +S + + C + S WS+W+PCS TC GS L R R R V
Sbjct: 57 CLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQL---RYR-RCVGWNGQCS 112
Query: 345 GKECPELLEKEACIVEGELLQQCPRY-SWR-TSEWKECQVSLLLEQQDPHWHVTGPVCGG 402
GK P LE + E + Q CP W W+ C V+ C
Sbjct: 113 GKVAPGTLEWQLQACEDQ--QCCPEMGGWSGWGPWEPCSVT----------------CSK 154
Query: 403 GIQTREVYCAQSVPAAAALRAKEVSRPVEKALCVGPAPLPSQLCNIP--CSTDCIVSSWS 460
G +TR C P C G A S+ C+ C T ++W
Sbjct: 155 GTRTRRRACNHPAPKCG-------------GHCPGQAQ-ESEACDTQQVCPTHGAWATWG 200
Query: 461 AWGLCIHENCH-DPQGKKGFRTRQRHVLMESTGPAGH-CPHLVES-------VPCEDPMC 511
W C +CH P K R+R+ S P G CP L PC P+
Sbjct: 201 PWTPC-SASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPC--PVA 257
Query: 512 YRWLASEGICFPDHGKCGLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSCE--IPCRM 569
W G P CGLG + + C N G C C +PC +
Sbjct: 258 GGW-GPWGPVSPCPVTCGLGQTMEQRTC-NHPVPQHGGPFC-AGDATRTHICNTAVPCPV 314
Query: 570 DCVLSEWTEWSSC----SQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHRLCN 625
D W EWS C +S S + G+Q+R RT +G + C Q H
Sbjct: 315 DGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHR-CAGQQQDIRHCYSI 373
Query: 626 DHSCMQLHW-ETSPWGPC 642
H ++ W E S WG C
Sbjct: 374 QHCPLKGSWSEWSTWGLC 391
Score = 70.9 bits (172), Expect = 9e-12
Identities = 102/407 (25%), Positives = 147/407 (36%), Gaps = 69/407 (16%)
Query: 1071 GGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEWGLWSK---CPQSCDPHTMQRRTRHLL 1127
GG + C + +S L P C W LWS C +C + R R +
Sbjct: 49 GGVSVEDCCLNTAFAYQKRSGGLCQP--CRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVG 106
Query: 1128 RPSLNSRTCAEDS---QVQPCLLNENCFQFQ--YNLTEWSTCQLSENAPCGQGVRTRLLS 1182
S A + Q+Q C + C + W C ++ C +G RTR +
Sbjct: 107 WNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVT----CSKGTRTRRRA 162
Query: 1183 CVCSDGKPVSMDQCEQHNLEKPQRMSIPCLVE--CVVNCQLSGWTAWTECSQTCGHGG-- 1238
C P +C H + Q S C + C + + W WT CS +C HGG
Sbjct: 163 C----NHPAP--KCGGHCPGQAQE-SEACDTQQVCPTHGAWATWGPWTPCSASC-HGGPH 214
Query: 1239 --RMSRTRFIIMPTQGE---GRPCPTELTQEKTCP-VTPCYSWVLGNW------SACKLE 1286
+ +R+R P + G+PCP +++ C + PC V G W S C +
Sbjct: 215 EPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCP--VAGGWGPWGPVSPCPVT 272
Query: 1287 GGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSILKQLCS--VPCPGDCHL 1344
CG G + +C +H + C D+ +C+ VPCP D
Sbjct: 273 ---CGLGQTMEQRTC-------NHPVPQHGGPFCAG----DATRTHICNTAVPCPVDGEW 318
Query: 1345 TEWSEWSTCELTCIDGRSFETV-GRQSRSRTFIIQSFENQDSCPQQVLETRPCTGGKCYH 1403
W EWS C + S + + G+QSR RT + F+ C Q + R C H
Sbjct: 319 DSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGH-RCAGQQQDIRHCY--SIQH 375
Query: 1404 YTWKASLWNNNERTVWCQRSDGVNVTGGCSPQARPAAIRQCIPACRK 1450
K S W + S C P A R C P K
Sbjct: 376 CPLKGS---------WSEWSTWGLCMPPCGPNPTRARQRLCTPLLPK 413
Score = 67.0 bits (162), Expect = 1e-10
Identities = 92/385 (23%), Positives = 126/385 (32%), Gaps = 90/385 (23%)
Query: 629 CMQLHWET-SPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRC 687
C W S W PCS TC G Q R CV + GQ C
Sbjct: 75 CRSPRWSLWSTWAPCS-----------------VTCSEGSQLRYRRCVGWN-GQ-----C 111
Query: 688 PDSTRPETVRPCFLPCK-KDCIV-----TAFSEWTPCPRMCQAGNATVKQSRYRIIIQEA 741
P T+ C+ + C + + W PC C G T R R A
Sbjct: 112 SGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRT----RRRACNHPA 167
Query: 742 ANGGQECPDTLYEERECEDVSLCPVY----RWKPQKWSPCILVPESVWQGITGSSEACGK 797
G CP E C+ +CP + W P W+PC S +C
Sbjct: 168 PKCGGHCPGQAQESEACDTQQVCPTHGAWATWGP--WTPC--------------SASCHG 211
Query: 798 G----LQTRAVSCISDDNRSAEMMECLKQTNGMPLLVQECT--VPCREDCTFTAWSKFTP 851
G +TR+ C + + K G+ + CT PC + W +P
Sbjct: 212 GPHEPKETRSRKCSAPEPSQKPPG---KPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSP 268
Query: 852 CSTNCEATKSRRRQLTGKSRKKEK----CQDSDLYPLVETEL-CPCD-EFISQPYGNWSD 905
C C ++ ++ + D+ + T + CP D E+ S +G WS
Sbjct: 269 CPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDS--WGEWSP 326
Query: 906 CILPEGRREPHRGLRVQADSKECGE--GLRFRAVACSDKNGRPVDPSFCSSSGYIQEKC- 962
CI R S C E G + R C GR D C+ C
Sbjct: 327 CI------------RRNMKSISCQEIPGQQSRGRTC---RGRKFDGHRCAGQQQDIRHCY 371
Query: 963 -VIPCPFDCKLSDWSSWGSCSSSCG 986
+ CP S+WS+WG C CG
Sbjct: 372 SIQHCPLKGSWSEWSTWGLCMPPCG 396
Score = 60.1 bits (144), Expect = 2e-08
Identities = 99/430 (23%), Positives = 139/430 (32%), Gaps = 93/430 (21%)
Query: 852 CSTNCEATKSRRRQLTGKSRKKEKC--QDSDLYPLVETELC-PCDEFISQPYGNWSDCIL 908
C T E + + + L G E C + Y LC PC + W+ C +
Sbjct: 32 CFTQYEESSGKCKGLLGGGVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSV 91
Query: 909 P--EGRREPHR---GLRVQADSKECGEGLRFRAVACSDKNGRPVDPSFCSSSGYIQEKCV 963
EG + +R G Q K L ++ AC D ++C
Sbjct: 92 TCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACED------------------QQC- 132
Query: 964 IPCPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHEAVP 1023
CP S W W CS +C G R R + G CP QAQ EA
Sbjct: 133 --CPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCP-----GQAQESEACD 185
Query: 1024 CYSECNQY-SWVV-EHWSSCKINNELRSLRCGGG------TQSRKIRCVNTADGEGGAVD 1075
C + +W W+ C S C GG T+SRK + G
Sbjct: 186 TQQVCPTHGAWATWGPWTPC-------SASCHGGPHEPKETRSRKCSAPEPSQKPPGKPC 238
Query: 1076 SNLCNQDE----IPPETQSCSLMCPNECVMSEWGLWSKCPQSCD-PHTMQRRTRHLLRPS 1130
L + +PP CP WG S CP +C TM++RT + P
Sbjct: 239 PGLAYEQRRCTGLPP--------CPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQ 290
Query: 1131 LNSRTCAED-------SQVQPCLLNENCFQFQYNLTEWSTCQLSENAPCGQGVRTRLLSC 1183
CA D + PC ++ + EWS C +R + S
Sbjct: 291 HGGPFCAGDATRTHICNTAVPCPVDGEWDSW----GEWSPC-----------IRRNMKSI 335
Query: 1184 VC-------SDGKPVSMDQCEQHNLEKPQRMSIPC--LVECVVNCQLSGWTAWTECSQTC 1234
C S G+ + + H Q+ C + C + S W+ W C C
Sbjct: 336 SCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPC 395
Query: 1235 GHGGRMSRTR 1244
G +R R
Sbjct: 396 GPNPTRARQR 405
Score = 52.4 bits (124), Expect = 3e-06
Identities = 84/354 (23%), Positives = 120/354 (33%), Gaps = 70/354 (19%)
Query: 101 VTAQHGLQHRMVRCIQ---KLNRTVVANEICEHFALQPPTEQACLIPCPRDCVVSEFLPW 157
VT G Q R RC+ + + V + + LQ +Q C CP S + PW
Sbjct: 91 VTCSEGSQLRYRRCVGWNGQCSGKVAPGTL--EWQLQACEDQQC---CPEMGGWSGWGPW 145
Query: 158 SNCSKGCGKKLQHRTRAVIAPPLFGGLQCP-NLTESRACDAPISCPLGEEEYTFSLKVGP 216
CS C K + R RA P G CP ES ACD CP T+ GP
Sbjct: 146 EPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATW----GP 201
Query: 217 WSKCRL-----PHLKEINPSGRTVLDFNSDSNERVTFKHQSYKAHH--------HSKSW- 262
W+ C PH + S + S +Y+ + W
Sbjct: 202 WTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWG 261
Query: 263 ----------AIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIM--PKDCETSQ 310
+G Q +C Q+ C D+ + + + P D E
Sbjct: 262 PWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGG-PFCAGDATRTHICNTAVPCPVDGEWDS 320
Query: 311 WSSWSPC------SKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEGELL 364
W WSPC S +C+ +PG +SR R + G + + + C +
Sbjct: 321 WGEWSPCIRRNMKSISCQE---IPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCY----SI 373
Query: 365 QQCP-RYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCG-GGIQTREVYCAQSVP 416
Q CP + SW SEW W + P CG + R+ C +P
Sbjct: 374 QHCPLKGSW--SEWST-------------WGLCMPPCGPNPTRARQRLCTPLLP 412
Score = 37.7 bits (86), Expect = 0.088
Identities = 64/314 (20%), Positives = 102/314 (32%), Gaps = 69/314 (21%)
Query: 16 GPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFRVCDWHSDLFQW 75
GPW C+ C G ++R C H +C + + +VC H W
Sbjct: 143 GPWEPCSVTCSKG-TRTRRRACNHPAPKCG--GHCPGQAQESEACDTQQVCPTHGAWATW 199
Query: 76 EVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQH-RMVRCIQKLNRTVVANEICEHFALQ 134
G P +A C H + R +C + C A +
Sbjct: 200 ---------------GPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYE 244
Query: 135 PPTEQAC--LIPCPRDCVVSEFLPWSNCSK-----GCGKKLQHRTRAVIAPPLFGGLQCP 187
++ C L PCP V + PW S G G+ ++ RT P G
Sbjct: 245 ---QRRCTGLPPCP---VAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAG 298
Query: 188 NLTESRACDAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDSNERVT 247
+ T + C+ + CP+ E ++ G WS C ++K I + + + T
Sbjct: 299 DATRTHICNTAVPCPVDGEWDSW----GEWSPCIRRNMKSI-----SCQEIPGQQSRGRT 349
Query: 248 FKHQSYKAHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCE 307
+ + + H R GQ + C ++Q C P
Sbjct: 350 CRGRKFDGH--------------------RCAGQQQDIRHC------YSIQHC--PLKGS 381
Query: 308 TSQWSSWSPCSKTC 321
S+WS+W C C
Sbjct: 382 WSEWSTWGLCMPPC 395
>gi|223671861 complement factor properdin precursor [Homo sapiens]
Length = 469
Score = 76.6 bits (187), Expect = 2e-13
Identities = 91/366 (24%), Positives = 135/366 (36%), Gaps = 51/366 (13%)
Query: 776 PCILVPESVWQGITGSSEACGKGLQTRAVSCISDDNR-SAEMMECLKQTNGMPLLVQECT 834
PC S+W S C +G Q R C+ + + S ++ + Q+C
Sbjct: 74 PCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQC- 132
Query: 835 VPCREDCTFTAWSKFTPCSTNC-EATKSRRRQLTGKSRKKEKCQDSDLYPLVETELCPCD 893
C E ++ W + PCS C + T++RRR + KC E+E C
Sbjct: 133 --CPEMGGWSGWGPWEPCSVTCSKGTRTRRRAC---NHPAPKCGGHCPGQAQESEACDTQ 187
Query: 894 EFIS-----QPYGNWSDCILP--EGRREPHRGLRVQADSKECGEGLRFRAVACSDK-NGR 945
+ +G W+ C G EP + S++C A S K G+
Sbjct: 188 QVCPTHGAWATWGPWTPCSASCHGGPHEPK-----ETRSRKCS------APEPSQKPPGK 236
Query: 946 PVDPSFCSSSGYIQEKC--VIPCPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEK-PYN 1002
P C Y Q +C + PCP W C +CG+G + + P +
Sbjct: 237 P-----CPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQH 291
Query: 1003 GGRPCPKLDLKNQAQVHEAVPCYSECNQYSWVVEHWSSCKINNELRSLRCG--GGTQSRK 1060
GG C D + AVPC + SW WS C I ++S+ C G QSR
Sbjct: 292 GGPFCAG-DATRTHICNTAVPCPVDGEWDSW--GEWSPC-IRRNMKSISCQEIPGQQSRG 347
Query: 1061 IRCVNTADGEGGAVDSNLCNQDEIPPETQSCSLM--CPNECVMSEWGLWSKCPQSCDPHT 1118
C G D + C + + + C + CP + SEW W C C P+
Sbjct: 348 RTC------RGRKFDGHRCAGQQ--QDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNP 399
Query: 1119 MQRRTR 1124
+ R R
Sbjct: 400 TRARQR 405
Score = 75.9 bits (185), Expect = 3e-13
Identities = 103/378 (27%), Positives = 135/378 (35%), Gaps = 66/378 (17%)
Query: 288 CLQDSFPLTVQSCIMPKDCET---SQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGG 344
CL +F +S + + C + S WS+W+PCS TC GS L R R R V
Sbjct: 57 CLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQL---RYR-RCVGWNGQCS 112
Query: 345 GKECPELLEKEACIVEGELLQQCPRY-SWR-TSEWKECQVSLLLEQQDPHWHVTGPVCGG 402
GK P LE + E + Q CP W W+ C V+ C
Sbjct: 113 GKVAPGTLEWQLQACEDQ--QCCPEMGGWSGWGPWEPCSVT----------------CSK 154
Query: 403 GIQTREVYCAQSVPAAAALRAKEVSRPVEKALCVGPAPLPSQLCNIP--CSTDCIVSSWS 460
G +TR C P C G A S+ C+ C T ++W
Sbjct: 155 GTRTRRRACNHPAPKCG-------------GHCPGQAQ-ESEACDTQQVCPTHGAWATWG 200
Query: 461 AWGLCIHENCH-DPQGKKGFRTRQRHVLMESTGPAGH-CPHLVES-------VPCEDPMC 511
W C +CH P K R+R+ S P G CP L PC P+
Sbjct: 201 PWTPC-SASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPC--PVA 257
Query: 512 YRWLASEGICFPDHGKCGLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSCE--IPCRM 569
W G P CGLG + + C N G C C +PC +
Sbjct: 258 GGW-GPWGPVSPCPVTCGLGQTMEQRTC-NHPVPQHGGPFC-AGDATRTHICNTAVPCPV 314
Query: 570 DCVLSEWTEWSSC----SQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHRLCN 625
D W EWS C +S S + G+Q+R RT +G + C Q H
Sbjct: 315 DGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHR-CAGQQQDIRHCYSI 373
Query: 626 DHSCMQLHW-ETSPWGPC 642
H ++ W E S WG C
Sbjct: 374 QHCPLKGSWSEWSTWGLC 391
Score = 70.9 bits (172), Expect = 9e-12
Identities = 102/407 (25%), Positives = 147/407 (36%), Gaps = 69/407 (16%)
Query: 1071 GGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEWGLWSK---CPQSCDPHTMQRRTRHLL 1127
GG + C + +S L P C W LWS C +C + R R +
Sbjct: 49 GGVSVEDCCLNTAFAYQKRSGGLCQP--CRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVG 106
Query: 1128 RPSLNSRTCAEDS---QVQPCLLNENCFQFQ--YNLTEWSTCQLSENAPCGQGVRTRLLS 1182
S A + Q+Q C + C + W C ++ C +G RTR +
Sbjct: 107 WNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVT----CSKGTRTRRRA 162
Query: 1183 CVCSDGKPVSMDQCEQHNLEKPQRMSIPCLVE--CVVNCQLSGWTAWTECSQTCGHGG-- 1238
C P +C H + Q S C + C + + W WT CS +C HGG
Sbjct: 163 C----NHPAP--KCGGHCPGQAQE-SEACDTQQVCPTHGAWATWGPWTPCSASC-HGGPH 214
Query: 1239 --RMSRTRFIIMPTQGE---GRPCPTELTQEKTCP-VTPCYSWVLGNW------SACKLE 1286
+ +R+R P + G+PCP +++ C + PC V G W S C +
Sbjct: 215 EPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCP--VAGGWGPWGPVSPCPVT 272
Query: 1287 GGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSILKQLCS--VPCPGDCHL 1344
CG G + +C +H + C D+ +C+ VPCP D
Sbjct: 273 ---CGLGQTMEQRTC-------NHPVPQHGGPFCAG----DATRTHICNTAVPCPVDGEW 318
Query: 1345 TEWSEWSTCELTCIDGRSFETV-GRQSRSRTFIIQSFENQDSCPQQVLETRPCTGGKCYH 1403
W EWS C + S + + G+QSR RT + F+ C Q + R C H
Sbjct: 319 DSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGH-RCAGQQQDIRHCY--SIQH 375
Query: 1404 YTWKASLWNNNERTVWCQRSDGVNVTGGCSPQARPAAIRQCIPACRK 1450
K S W + S C P A R C P K
Sbjct: 376 CPLKGS---------WSEWSTWGLCMPPCGPNPTRARQRLCTPLLPK 413
Score = 67.0 bits (162), Expect = 1e-10
Identities = 92/385 (23%), Positives = 126/385 (32%), Gaps = 90/385 (23%)
Query: 629 CMQLHWET-SPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRC 687
C W S W PCS TC G Q R CV + GQ C
Sbjct: 75 CRSPRWSLWSTWAPCS-----------------VTCSEGSQLRYRRCVGWN-GQ-----C 111
Query: 688 PDSTRPETVRPCFLPCK-KDCIV-----TAFSEWTPCPRMCQAGNATVKQSRYRIIIQEA 741
P T+ C+ + C + + W PC C G T R R A
Sbjct: 112 SGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRT----RRRACNHPA 167
Query: 742 ANGGQECPDTLYEERECEDVSLCPVY----RWKPQKWSPCILVPESVWQGITGSSEACGK 797
G CP E C+ +CP + W P W+PC S +C
Sbjct: 168 PKCGGHCPGQAQESEACDTQQVCPTHGAWATWGP--WTPC--------------SASCHG 211
Query: 798 G----LQTRAVSCISDDNRSAEMMECLKQTNGMPLLVQECT--VPCREDCTFTAWSKFTP 851
G +TR+ C + + K G+ + CT PC + W +P
Sbjct: 212 GPHEPKETRSRKCSAPEPSQKPPG---KPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSP 268
Query: 852 CSTNCEATKSRRRQLTGKSRKKEK----CQDSDLYPLVETEL-CPCD-EFISQPYGNWSD 905
C C ++ ++ + D+ + T + CP D E+ S +G WS
Sbjct: 269 CPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDS--WGEWSP 326
Query: 906 CILPEGRREPHRGLRVQADSKECGE--GLRFRAVACSDKNGRPVDPSFCSSSGYIQEKC- 962
CI R S C E G + R C GR D C+ C
Sbjct: 327 CI------------RRNMKSISCQEIPGQQSRGRTC---RGRKFDGHRCAGQQQDIRHCY 371
Query: 963 -VIPCPFDCKLSDWSSWGSCSSSCG 986
+ CP S+WS+WG C CG
Sbjct: 372 SIQHCPLKGSWSEWSTWGLCMPPCG 396
Score = 60.1 bits (144), Expect = 2e-08
Identities = 99/430 (23%), Positives = 139/430 (32%), Gaps = 93/430 (21%)
Query: 852 CSTNCEATKSRRRQLTGKSRKKEKC--QDSDLYPLVETELC-PCDEFISQPYGNWSDCIL 908
C T E + + + L G E C + Y LC PC + W+ C +
Sbjct: 32 CFTQYEESSGKCKGLLGGGVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSV 91
Query: 909 P--EGRREPHR---GLRVQADSKECGEGLRFRAVACSDKNGRPVDPSFCSSSGYIQEKCV 963
EG + +R G Q K L ++ AC D ++C
Sbjct: 92 TCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACED------------------QQC- 132
Query: 964 IPCPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHEAVP 1023
CP S W W CS +C G R R + G CP QAQ EA
Sbjct: 133 --CPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCP-----GQAQESEACD 185
Query: 1024 CYSECNQY-SWVV-EHWSSCKINNELRSLRCGGG------TQSRKIRCVNTADGEGGAVD 1075
C + +W W+ C S C GG T+SRK + G
Sbjct: 186 TQQVCPTHGAWATWGPWTPC-------SASCHGGPHEPKETRSRKCSAPEPSQKPPGKPC 238
Query: 1076 SNLCNQDE----IPPETQSCSLMCPNECVMSEWGLWSKCPQSCD-PHTMQRRTRHLLRPS 1130
L + +PP CP WG S CP +C TM++RT + P
Sbjct: 239 PGLAYEQRRCTGLPP--------CPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQ 290
Query: 1131 LNSRTCAED-------SQVQPCLLNENCFQFQYNLTEWSTCQLSENAPCGQGVRTRLLSC 1183
CA D + PC ++ + EWS C +R + S
Sbjct: 291 HGGPFCAGDATRTHICNTAVPCPVDGEWDSW----GEWSPC-----------IRRNMKSI 335
Query: 1184 VC-------SDGKPVSMDQCEQHNLEKPQRMSIPC--LVECVVNCQLSGWTAWTECSQTC 1234
C S G+ + + H Q+ C + C + S W+ W C C
Sbjct: 336 SCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPC 395
Query: 1235 GHGGRMSRTR 1244
G +R R
Sbjct: 396 GPNPTRARQR 405
Score = 52.4 bits (124), Expect = 3e-06
Identities = 84/354 (23%), Positives = 120/354 (33%), Gaps = 70/354 (19%)
Query: 101 VTAQHGLQHRMVRCIQ---KLNRTVVANEICEHFALQPPTEQACLIPCPRDCVVSEFLPW 157
VT G Q R RC+ + + V + + LQ +Q C CP S + PW
Sbjct: 91 VTCSEGSQLRYRRCVGWNGQCSGKVAPGTL--EWQLQACEDQQC---CPEMGGWSGWGPW 145
Query: 158 SNCSKGCGKKLQHRTRAVIAPPLFGGLQCP-NLTESRACDAPISCPLGEEEYTFSLKVGP 216
CS C K + R RA P G CP ES ACD CP T+ GP
Sbjct: 146 EPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATW----GP 201
Query: 217 WSKCRL-----PHLKEINPSGRTVLDFNSDSNERVTFKHQSYKAHH--------HSKSW- 262
W+ C PH + S + S +Y+ + W
Sbjct: 202 WTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWG 261
Query: 263 ----------AIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIM--PKDCETSQ 310
+G Q +C Q+ C D+ + + + P D E
Sbjct: 262 PWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGG-PFCAGDATRTHICNTAVPCPVDGEWDS 320
Query: 311 WSSWSPC------SKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEGELL 364
W WSPC S +C+ +PG +SR R + G + + + C +
Sbjct: 321 WGEWSPCIRRNMKSISCQE---IPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCY----SI 373
Query: 365 QQCP-RYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCG-GGIQTREVYCAQSVP 416
Q CP + SW SEW W + P CG + R+ C +P
Sbjct: 374 QHCPLKGSW--SEWST-------------WGLCMPPCGPNPTRARQRLCTPLLP 412
Score = 37.7 bits (86), Expect = 0.088
Identities = 64/314 (20%), Positives = 102/314 (32%), Gaps = 69/314 (21%)
Query: 16 GPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFRVCDWHSDLFQW 75
GPW C+ C G ++R C H +C + + +VC H W
Sbjct: 143 GPWEPCSVTCSKG-TRTRRRACNHPAPKCG--GHCPGQAQESEACDTQQVCPTHGAWATW 199
Query: 76 EVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQH-RMVRCIQKLNRTVVANEICEHFALQ 134
G P +A C H + R +C + C A +
Sbjct: 200 ---------------GPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYE 244
Query: 135 PPTEQAC--LIPCPRDCVVSEFLPWSNCSK-----GCGKKLQHRTRAVIAPPLFGGLQCP 187
++ C L PCP V + PW S G G+ ++ RT P G
Sbjct: 245 ---QRRCTGLPPCP---VAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAG 298
Query: 188 NLTESRACDAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDSNERVT 247
+ T + C+ + CP+ E ++ G WS C ++K I + + + T
Sbjct: 299 DATRTHICNTAVPCPVDGEWDSW----GEWSPCIRRNMKSI-----SCQEIPGQQSRGRT 349
Query: 248 FKHQSYKAHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCE 307
+ + + H R GQ + C ++Q C P
Sbjct: 350 CRGRKFDGH--------------------RCAGQQQDIRHC------YSIQHC--PLKGS 381
Query: 308 TSQWSSWSPCSKTC 321
S+WS+W C C
Sbjct: 382 WSEWSTWGLCMPPC 395
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif, 6
preproprotein [Homo sapiens]
Length = 1117
Score = 76.3 bits (186), Expect = 2e-13
Identities = 73/275 (26%), Positives = 102/275 (37%), Gaps = 53/275 (19%)
Query: 1031 YSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQS 1090
++W + WS C S C GG Q +++ C D V +N C+ D PPE Q
Sbjct: 842 FTWNHQPWSEC-------SATCAGGVQRQEVVCKRLDDNS--IVQNNYCDPDSKPPENQR 892
Query: 1091 CSLMCPNECVMSEW--GLWSKCPQSCDPHTMQRRTRHLL---------RPSLNSRTCAED 1139
C E EW G W +C ++CD RTR +L +L+ C
Sbjct: 893 A---CNTEPCPPEWFIGDWLECSKTCDG---GMRTRAVLCIRKIGPSEEETLDYSGCLTH 946
Query: 1140 SQVQPCLLNENCFQFQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSD-GKPVSMDQCEQ 1198
V+ N Q+ +WS C CG G + R++ C SD K QC
Sbjct: 947 RPVEKEPCNNQSCPPQWVALDWSEC----TPKCGPGFKHRIVLCKSSDLSKTFPAAQC-- 1000
Query: 1199 HNLEKPQRMSIPCLVECVV-NCQLSGWTA--WTECSQTCGHGGRMSRTRFIIMPTQGEG- 1254
P+ P + C + C W W +CS CG G +M + + Q
Sbjct: 1001 -----PEESKPPVRIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSD 1055
Query: 1255 -----RPCPTELTQEKTCPVTPCYSWVLGNWSACK 1284
RP P+ E C TP + N CK
Sbjct: 1056 CLETVRP-PSMQQCESKCDSTP-----ISNTEECK 1084
Score = 55.8 bits (133), Expect = 3e-07
Identities = 50/194 (25%), Positives = 73/194 (37%), Gaps = 32/194 (16%)
Query: 17 PWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSN-CGESNRPPKERSCFRVCDWHSDLFQW 75
PW C+ C GGVQ + V C +D + +N C ++PP+ + R C+ +W
Sbjct: 848 PWSECSATCA-GGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQ---RACNTEPCPPEW 903
Query: 76 EVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHFALQP 135
+ DW C T G++ R V CI+K+ +
Sbjct: 904 FIGDWLEC----------------SKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHR 947
Query: 136 PTEQACLIPCPRDCVVSEF--LPWSNCSKGCGKKLQHRTRAVIAPPL---FGGLQCPNLT 190
P E+ PC ++ L WS C+ CG +HR + L F QCP
Sbjct: 948 PVEKE---PCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCP--- 1001
Query: 191 ESRACDAPISCPLG 204
E I C LG
Sbjct: 1002 EESKPPVRIRCSLG 1015
Score = 54.7 bits (130), Expect = 7e-07
Identities = 52/202 (25%), Positives = 74/202 (36%), Gaps = 44/202 (21%)
Query: 528 CGLGHRILKAVCQNDRG----EDVSGSLCPVPPPPERKSCEIPCRMDCVLSEWT--EWSS 581
C G R +C G E + S C P E++ PC +W +WS
Sbjct: 915 CDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKE----PCNNQSCPPQWVALDWSE 970
Query: 582 CSQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHR-----LCNDHSCMQLHWET 636
C+ C G + R +L + + K P +Q +E + C+ C W T
Sbjct: 971 CTPKC------GPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVT 1024
Query: 637 SPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPETV 696
WG CS A CG+G Q R V C+ S+ GQ + C ++ RP
Sbjct: 1025 GDWGQCS-----------------AQCGLGQQMRTVQCL-SYTGQA-SSDCLETVRP--- 1062
Query: 697 RPCFLPCKKDCIVTAFSEWTPC 718
P C+ C T S C
Sbjct: 1063 -PSMQQCESKCDSTPISNTEEC 1083
Score = 53.9 bits (128), Expect = 1e-06
Identities = 60/270 (22%), Positives = 94/270 (34%), Gaps = 57/270 (21%)
Query: 579 WSSCSQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHRLCNDHSCMQLHWETSP 638
WS CS +C+ + R + P S+ + R CN C W
Sbjct: 849 WSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPP-EWFIGD 907
Query: 639 WGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDS----TRPE 694
W CS+ TC G++TR V C++ +G + S RP
Sbjct: 908 WLECSK-----------------TCDGGMRTRAVLCIRK-IGPSEEETLDYSGCLTHRPV 949
Query: 695 TVRPC-FLPCKKDCIVTAFSEWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQECPDTLY 753
PC C + +W+ C C G ++RI++ ++++ + P
Sbjct: 950 EKEPCNNQSCPPQWVAL---DWSECTPKCGPG------FKHRIVLCKSSDLSKTFPAAQC 1000
Query: 754 EERECEDVSL------CPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCI 807
E V + CP RW W C S CG G Q R V C+
Sbjct: 1001 PEESKPPVRIRCSLGRCPPPRWVTGDWGQC--------------SAQCGLGQQMRTVQCL 1046
Query: 808 SDDNRSAEMMECLKQTNGMPLLVQECTVPC 837
S +++ +CL+ P +Q+C C
Sbjct: 1047 SYTGQASS--DCLETVR--PPSMQQCESKC 1072
Score = 52.4 bits (124), Expect = 3e-06
Identities = 64/270 (23%), Positives = 97/270 (35%), Gaps = 71/270 (26%)
Query: 370 YSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRP 429
++W W EC + C GG+Q +EV C + + +
Sbjct: 842 FTWNHQPWSECSAT----------------CAGGVQRQEVVC----------KRLDDNSI 875
Query: 430 VEKALCVGPAPLP--SQLCNI-PCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTR---- 482
V+ C + P + CN PC + + W L + C G RTR
Sbjct: 876 VQNNYCDPDSKPPENQRACNTEPCPPEWFIGDW----LECSKTCDG-----GMRTRAVLC 926
Query: 483 ------QRHVLMESTGPAGHCPHLVESVPCEDPMC-YRWLASE-GICFPDHGKCGLGHRI 534
++ +G H P VE PC + C +W+A + C P KCG G +
Sbjct: 927 IRKIGPSEEETLDYSGCLTHRP--VEKEPCNNQSCPPQWVALDWSECTP---KCGPGFKH 981
Query: 535 LKAVCQ-NDRGEDVSGSLCP-VPPPPERKSCEIPCRMDCVLSEWT--EWSSCSQSCSNKN 590
+C+ +D + + CP PP R C + C W +W CS C
Sbjct: 982 RIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLG---RCPPPRWVTGDWGQCSAQCGL-- 1036
Query: 591 SDGKQTRSRTILALAGEGGKPC-----PPS 615
G+Q R+ L+ G+ C PPS
Sbjct: 1037 --GQQMRTVQCLSYTGQASSDCLETVRPPS 1064
Score = 50.1 bits (118), Expect = 2e-05
Identities = 69/273 (25%), Positives = 99/273 (36%), Gaps = 68/273 (24%)
Query: 314 WSPCSKTCRSG----SLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEGELLQQCPR 369
WS CS TC G ++ + V++ + PE + AC E CP
Sbjct: 849 WSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPE--NQRACNTE-----PCPP 901
Query: 370 YSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRP 429
W +W EC C GG++TR V C + +
Sbjct: 902 -EWFIGDWLEC----------------SKTCDGGMRTRAVLCIRKI-------GPSEEET 937
Query: 430 VEKALCVGPAPLPSQLCNIPCSTDCIVSSWSA--WGLCIHENCHDPQGKKGFRTRQRHVL 487
++ + C+ P+ + PC+ W A W C P+ GF + R VL
Sbjct: 938 LDYSGCLTHRPVEKE----PCNNQSCPPQWVALDWSEC------TPKCGPGF--KHRIVL 985
Query: 488 MES-----TGPAGHCPHLVESVP-----CEDPMC--YRWLASE-GICFPDHGKCGLGHRI 534
+S T PA CP ES P C C RW+ + G C +CGLG ++
Sbjct: 986 CKSSDLSKTFPAAQCPE--ESKPPVRIRCSLGRCPPPRWVTGDWGQC---SAQCGLGQQM 1040
Query: 535 LKAVCQNDRGEDVSGSLCPVPPPPERKSCEIPC 567
C + G+ S L V PP + CE C
Sbjct: 1041 RTVQCLSYTGQASSDCLETV-RPPSMQQCESKC 1072
Score = 47.8 bits (112), Expect = 9e-05
Identities = 64/295 (21%), Positives = 100/295 (33%), Gaps = 61/295 (20%)
Query: 767 YRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCISDDNRSAEMMECLKQTNGM 826
+ W Q WS C S C G+Q + V C D+ S +
Sbjct: 842 FTWNHQPWSEC--------------SATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKP 887
Query: 827 PLLVQEC-TVPCREDCTFTAWSKFTPCSTNCEATKSRRRQLTGKS---RKKEKCQDSDLY 882
P + C T PC + W + CS C+ R L + ++E S
Sbjct: 888 PENQRACNTEPCPPEWFIGDWLE---CSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCL 944
Query: 883 PLVETELCPCDEFISQPYG---NWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVAC 939
E PC+ P +WS+C + +CG G + R V C
Sbjct: 945 THRPVEKEPCNNQSCPPQWVALDWSEC------------------TPKCGPGFKHRIVLC 986
Query: 940 SDKNGRPVDPSFCSSSGYIQEKCVIPCPFDCKLSD-----W--SSWGSCSSSCGIGVRIR 992
D S + E+ P C L W WG CS+ CG+G ++R
Sbjct: 987 KSS-----DLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMR 1041
Query: 993 SKWLKEKPYNGGRPCPKLDLKNQAQVHEAVPCYSECNQYSWVVEHWSSCKINNEL 1047
+ ++ Y G L+ + + C S+C+ S + + CK N++
Sbjct: 1042 T--VQCLSYTGQASSDCLETVRPPSMQQ---CESKCD--STPISNTEECKDVNKV 1089
Score = 47.8 bits (112), Expect = 9e-05
Identities = 54/243 (22%), Positives = 81/243 (33%), Gaps = 40/243 (16%)
Query: 1227 WTECSQTCGHGGRMSRT-------RFIIMPTQGEGRPCPTELTQEKTCPVTPC-YSWVLG 1278
W+ECS TC G + I+ + P E ++ C PC W +G
Sbjct: 849 WSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPE--NQRACNTEPCPPEWFIG 906
Query: 1279 NWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSILKQLCSVPC 1338
+W C C G++ R++ C+ G L P + PC
Sbjct: 907 DWLEC---SKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLT-HRPVEKE--------PC 954
Query: 1339 PGDCHLTEW--SEWSTCELTCIDGRSFETVGRQSR--SRTFIIQSFENQDSCPQQVLETR 1394
+W +WS C C G V +S S+TF + P ++
Sbjct: 955 NNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRI---- 1010
Query: 1395 PCTGGKCYHYTWKASLW---------NNNERTVWCQRSDGVNVTGGCSPQARPAAIRQCI 1445
C+ G+C W W RTV C G + C RP +++QC
Sbjct: 1011 RCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTG-QASSDCLETVRPPSMQQCE 1069
Query: 1446 PAC 1448
C
Sbjct: 1070 SKC 1072
Score = 43.1 bits (100), Expect = 0.002
Identities = 47/161 (29%), Positives = 63/161 (39%), Gaps = 28/161 (17%)
Query: 16 GPWGRCTGDCGPGGVQSRAVWCFHVDGWTSH--LSNCGESNRPPKERSCFRVCDWHSDLF 73
G W C+ C GG+++RAV C G + L G P E+ C+ S
Sbjct: 906 GDWLECSKTCD-GGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKE---PCNNQSCPP 961
Query: 74 QWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQK-LNRTVVANEICEHFA 132
QW DW C T +C G +HR+V C L++T A + E
Sbjct: 962 QWVALDWSEC-------------TPKCGP---GFKHRIVLCKSSDLSKTFPAAQCPEES- 1004
Query: 133 LQPPTEQACLIP-CPRDCVVSEFLPWSNCSKGCGKKLQHRT 172
+PP C + CP V+ W CS CG Q RT
Sbjct: 1005 -KPPVRIRCSLGRCPPPRWVTG--DWGQCSAQCGLGQQMRT 1042
Score = 42.7 bits (99), Expect = 0.003
Identities = 22/54 (40%), Positives = 28/54 (51%), Gaps = 3/54 (5%)
Query: 14 LAGPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFRVCD 67
+ G WG+C+ CG G Q R V C G S S+C E+ RPP + C CD
Sbjct: 1023 VTGDWGQCSAQCGL-GQQMRTVQCLSYTGQAS--SDCLETVRPPSMQQCESKCD 1073
Score = 41.2 bits (95), Expect = 0.008
Identities = 38/137 (27%), Positives = 54/137 (39%), Gaps = 23/137 (16%)
Query: 1148 NENCFQFQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMD-------QCEQHN 1200
+E C +FQY T + C G R L C+ + V+ C+ N
Sbjct: 487 DEQC-RFQYGAT---------SRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGN 536
Query: 1201 LEKPQRMSIPCLVECVVNCQLSG----WTAWTECSQTCGHGGRMSRTRFIIMPT-QGEGR 1255
+EK C+ + G W+ W ECS+TCG GG S R P G G+
Sbjct: 537 IEKGWCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCG-GGVSSSLRHCDSPAPSGGGK 595
Query: 1256 PCPTELTQEKTCPVTPC 1272
C E + ++C PC
Sbjct: 596 YCLGERKRYRSCNTDPC 612
Score = 40.0 bits (92), Expect = 0.018
Identities = 49/182 (26%), Positives = 64/182 (35%), Gaps = 44/182 (24%)
Query: 267 GYQTRQVSCTRSDGQNAMLSL----CLQ----DSFPLTVQSCIMPKDCETSQWSS--WSP 316
G +TR V C R G + +L CL + P QSC QW + WS
Sbjct: 918 GMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSC-------PPQWVALDWSE 970
Query: 317 CSKTCRSGSLLPGFRSRSRNVKHMAIGG---GKECPELLEKEACIVEGELLQQCPRYSWR 373
C+ C PGF+ R K + +CPE E + + L +CP W
Sbjct: 971 CTPKCG-----PGFKHRIVLCKSSDLSKTFPAAQCPE--ESKPPVRIRCSLGRCPPPRWV 1023
Query: 374 TSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKA 433
T +W +C CG G Q R V C S A+ E RP
Sbjct: 1024 TGDWGQCSAQ----------------CGLGQQMRTVQCL-SYTGQASSDCLETVRPPSMQ 1066
Query: 434 LC 435
C
Sbjct: 1067 QC 1068
Score = 37.0 bits (84), Expect = 0.15
Identities = 30/102 (29%), Positives = 40/102 (39%), Gaps = 17/102 (16%)
Query: 923 ADSKECGEGLRFRAVACSDKNGRPVDPSFCSSSGYI------------QEKCVI----PC 966
A S++C G R + C K+ R V S ++ G + Q CV P
Sbjct: 496 ATSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTWPQ 555
Query: 967 PFDCKLSDWSSWGSCSSSCGIGVRIRSKWL-KEKPYNGGRPC 1007
D WS WG CS +CG GV + P GG+ C
Sbjct: 556 SIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYC 597
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 75.5 bits (184), Expect = 4e-13
Identities = 113/438 (25%), Positives = 164/438 (37%), Gaps = 93/438 (21%)
Query: 925 SKECGEGLRFRAVACSDKNGRP-VDPSFCSSSGYIQ---EKCVI-PCPFDCKLSDWSSWG 979
S CG GLR+ +C D+ + V+ C S E CV+ PCP + D+ G
Sbjct: 665 SVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDF---G 721
Query: 980 SCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHEAVPCYSECNQY----SWVV 1035
CS+SCG G+R R E + + P + AQ + CN W V
Sbjct: 722 PCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQ--QPAVALETCNPQPCPARWEV 779
Query: 1036 EHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQSC-SLM 1094
SSC + G G CV ADG V + DE P + C +
Sbjct: 780 SEPSSC-------TSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMS 832
Query: 1095 CP-----------NECVMSEWG----------LWS----KCPQSCDPHTMQRR---TRHL 1126
CP E S WG +W+ C SC M+ R
Sbjct: 833 CPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSA 892
Query: 1127 LRPSLNSRTCA---------EDSQVQPCLLNENCFQFQYNLTEWSTCQLSENAPCGQGVR 1177
LR + C E Q PC ++QY L + C +S CG+GV
Sbjct: 893 LRVPVQEELCGLASKPGSRREVCQAVPCPA-----RWQYKL---AACSVS----CGRGVV 940
Query: 1178 TRLLSCVCS----DGKPVSMD-QCEQHNLEKPQRMSIPCLVECVVNCQLSGWTAWTECSQ 1232
R+L C + DG+ + +D QC+ L +P+ L C ++ + CS
Sbjct: 941 RRILYCARAHGEDDGEEILLDTQCQ--GLPRPEPQEACSLEPCPPRWKV---MSLGPCSA 995
Query: 1233 TCGHGGRMSRTRFIIMPTQGEG-----RPCPTELTQEKT--CPVTPC-YSWVLGNWSACK 1284
+CG G R+ + QG+ C + E + C + C Y W +G W C
Sbjct: 996 SCGL-GTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECS 1054
Query: 1285 LEGGDCGEGVQIRSLSCM 1302
+ CG+G+Q R +C+
Sbjct: 1055 V---SCGDGIQRRRDTCL 1069
Score = 55.1 bits (131), Expect = 5e-07
Identities = 123/498 (24%), Positives = 164/498 (32%), Gaps = 93/498 (18%)
Query: 691 TRPETVRPCFLPCKKDCIVTAFSEWTPCPRMCQAGNATVK-----QSRYRIIIQEAANGG 745
TRP+ F P + V A PC C AG V Q+R ++ G
Sbjct: 638 TRPDITFTYFQPKPRQAWVWAAVRG-PCSVSCGAGLRWVNYSCLDQARKELVETVQCQGS 696
Query: 746 QECPDTLYEERECEDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVS 805
Q+ P E + CP Y W + PC S +CG GL+ R V
Sbjct: 697 QQPPAW----PEACVLEPCPPY-WAVGDFGPC--------------SASCGGGLRERPVR 737
Query: 806 CISDDNRSAEMMECLKQTNG--MPLLVQECTVPCREDCTFTAWSKFTPCSTNCEATKSRR 863
C+ + + + G P + E P + C W P S C +
Sbjct: 738 CVEAQGSLLKTLPPARCRAGAQQPAVALETCNP--QPCP-ARWEVSEPSS--CTSAGG-- 790
Query: 864 RQLTGKSRKKEKC---QDSDLYPLVE-----TELCPCDE---FISQP--YGNWSDCILPE 910
G + + E C D P+ E E P E +S P +G+ E
Sbjct: 791 ---AGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGE 847
Query: 911 GRREPHRGLRVQAD------------SKECGEGLRFRAVACSDKNGR-PVDPSFC---SS 954
P +R A S CG GL C D R PV C S
Sbjct: 848 KAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASK 907
Query: 955 SGYIQEKC-VIPCPFDCKLSDWS-SWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDL 1012
G +E C +PCP + W +CS SCG GV R + +G ++ L
Sbjct: 908 PGSRREVCQAVPCP-----ARWQYKLAACSVSCGRGVVRRILYCARA--HGEDDGEEILL 960
Query: 1013 KNQAQ----VHEAVPCYSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTAD 1068
Q Q C E W V C S CG GT R + CV
Sbjct: 961 DTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPC-------SASCGLGTARRSVACVQLDQ 1013
Query: 1069 GEGGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEW--GLWSKCPQSCDPHTMQRRTRHL 1126
G+ VD C P + C + +C W G W +C SC +QRR
Sbjct: 1014 GQDVEVDEAACAALVRPEASVPCLIA---DCTY-RWHVGTWMECSVSCG-DGIQRRRDTC 1068
Query: 1127 LRPSLNSRTCAEDSQVQP 1144
L P + A+ Q P
Sbjct: 1069 LGPQAQAPVPADFCQHLP 1086
Score = 55.1 bits (131), Expect = 5e-07
Identities = 103/472 (21%), Positives = 159/472 (33%), Gaps = 109/472 (23%)
Query: 303 PKDCETSQWSSW-SPCSKTCRSGSLLPGF----RSRSRNVKHMAIGGGKECPELLEKEAC 357
PK + W++ PCS +C +G + ++R V+ + G ++ P EAC
Sbjct: 649 PKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAW--PEAC 706
Query: 358 IVEGELLQQCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPA 417
++E CP Y W ++ C S CGGG++ R V C ++ +
Sbjct: 707 VLE-----PCPPY-WAVGDFGPCSAS----------------CGGGLRERPVRCVEAQGS 744
Query: 418 A------AALRAKEVSRPVEKALCVGPAPLPSQ------------------LCNIPC--S 451
A RA V C P P P++ L N C
Sbjct: 745 LLKTLPPARCRAGAQQPAVALETC-NPQPCPARWEVSEPSSCTSAGGAGLALENETCVPG 803
Query: 452 TDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVESVPCEDPMC 511
D + + + + E P+ G +++T P S+
Sbjct: 804 ADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAA 863
Query: 512 YRWLASEGICFPDHGKCGLGHRILKAVCQNDRGE-DVSGSLCPVPPPP--ERKSCE-IPC 567
+ W + G C CG G L+ +C + V LC + P R+ C+ +PC
Sbjct: 864 HVWTPAAGSCSVS---CGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPC 920
Query: 568 RMDCVLSEWT-EWSSCSQSCSN---------KNSDGKQTRSRTILALAGEGGKPCPPSQA 617
+ W + ++CS SC + G+ +L +G P +A
Sbjct: 921 P-----ARWQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEA 975
Query: 618 LQEHRLCNDHSCMQLHWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKS 677
C+ C W+ GPCS A+CG+G R V CV+
Sbjct: 976 ------CSLEPCPP-RWKVMSLGPCS-----------------ASCGLGTARRSVACVQL 1011
Query: 678 HVGQ---VMTKRCPDSTRPETVRPCFLPCKKDCIVT-AFSEWTPCPRMCQAG 725
GQ V C RPE PC + DC W C C G
Sbjct: 1012 DQGQDVEVDEAACAALVRPEASVPCLI---ADCTYRWHVGTWMECSVSCGDG 1060
Score = 44.3 bits (103), Expect = 0.001
Identities = 56/248 (22%), Positives = 90/248 (36%), Gaps = 53/248 (21%)
Query: 637 SPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVG-QVMTKRCPDSTRPET 695
SPWG + + +CG G+ R C+ S + V + C +++P +
Sbjct: 851 SPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGS 910
Query: 696 VRPCFLPCKKDCIVTAFSEWTPCPRMCQAGNATVKQSRYRIIIQE----AANGGQECPDT 751
R + PCP Q A S R +++ A G++ +
Sbjct: 911 RREV-------------CQAVPCPARWQYKLAACSVSCGRGVVRRILYCARAHGEDDGEE 957
Query: 752 LYEERECE-----------DVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQ 800
+ + +C+ + CP RWK PC S +CG G
Sbjct: 958 ILLDTQCQGLPRPEPQEACSLEPCPP-RWKVMSLGPC--------------SASCGLGTA 1002
Query: 801 TRAVSCIS-DDNRSAEMMECLKQTNGMPLLVQECTVPCR-EDCTFTAW--SKFTPCSTNC 856
R+V+C+ D + E+ E L+ E +VPC DCT+ W + CS +C
Sbjct: 1003 RRSVACVQLDQGQDVEVDEAACAA----LVRPEASVPCLIADCTY-RWHVGTWMECSVSC 1057
Query: 857 EATKSRRR 864
RRR
Sbjct: 1058 GDGIQRRR 1065
Score = 41.6 bits (96), Expect = 0.006
Identities = 93/419 (22%), Positives = 139/419 (33%), Gaps = 91/419 (21%)
Query: 16 GPWGRCTGDCGPGGVQSRAVWCFHVDGW---TSHLSNCGESNRPPKERSCFRVCDWHSDL 72
G +G C+ CG GG++ R V C G T + C + P C+
Sbjct: 718 GDFGPCSASCG-GGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAV--ALETCNPQPCP 774
Query: 73 FQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHFA 132
+WEVS+ C A ++ T CV GL+ +
Sbjct: 775 ARWEVSEPSSCTSAGGAGLALENET--CVPGADGLEAPVT-------------------- 812
Query: 133 LQPPTEQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFG----GLQCPN 188
+ P +P P CV +C G G L + AP +G G Q +
Sbjct: 813 -EGPGSVDEKLPAPEPCV------GMSCPPGWGH-LDATSAGEKAPSPWGSIRTGAQAAH 864
Query: 189 LTESRACDAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDSNERVTF 248
+ A +SC G E F S R+P +E+ + + R
Sbjct: 865 VWTPAAGSCSVSCGRGLMELRFLCMD---SALRVPVQEELCGLA------SKPGSRREVC 915
Query: 249 KHQSYKAHHHSKSWAIEI----GYQTRQVSCTRS----DGQNAMLSL-CLQDSFPLTVQS 299
+ A K A + G R + C R+ DG+ +L C P ++
Sbjct: 916 QAVPCPARWQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEA 975
Query: 300 CIMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKE-------CPELL 352
C + + S PCS +C G + R+V + + G++ C L+
Sbjct: 976 CSLEPCPPRWKVMSLGPCSASC-------GLGTARRSVACVQLDQGQDVEVDEAACAALV 1028
Query: 353 EKEACIVEGELLQQCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYC 411
EA + L+ C Y W W EC VS CG GIQ R C
Sbjct: 1029 RPEASVPC--LIADCT-YRWHVGTWMECSVS----------------CGDGIQRRRDTC 1068
Score = 38.9 bits (89), Expect = 0.040
Identities = 37/158 (23%), Positives = 57/158 (36%), Gaps = 34/158 (21%)
Query: 662 TCGVGIQTRRVFCVKSHVGQ-----VMTKRCPDSTRPETVRPCFL-PCKKDCIVTAFSEW 715
+CG G+ R ++C ++H ++ +C RPE C L PC V +
Sbjct: 934 SCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLG-- 991
Query: 716 TPCPRMCQAGNATVKQSRYR------IIIQEAANGGQECPDTLYEERECEDVSLCPVYRW 769
PC C G A + + + + EAA C + E + YRW
Sbjct: 992 -PCSASCGLGTARRSVACVQLDQGQDVEVDEAA-----CAALVRPEASVPCLIADCTYRW 1045
Query: 770 KPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCI 807
W C S +CG G+Q R +C+
Sbjct: 1046 HVGTWMEC--------------SVSCGDGIQRRRDTCL 1069
Score = 35.8 bits (81), Expect = 0.34
Identities = 23/54 (42%), Positives = 27/54 (50%), Gaps = 6/54 (11%)
Query: 975 WSSWGS---CSSSCGIGVRIRSKWLKE-KPYNGGRPCPKLDLKNQAQVHEAVPC 1024
WSSWG CS SCG GV R + +P GGR C DL QA++ C
Sbjct: 356 WSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADL--QAEMCNTQAC 407
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 75.5 bits (184), Expect = 4e-13
Identities = 113/438 (25%), Positives = 164/438 (37%), Gaps = 93/438 (21%)
Query: 925 SKECGEGLRFRAVACSDKNGRP-VDPSFCSSSGYIQ---EKCVI-PCPFDCKLSDWSSWG 979
S CG GLR+ +C D+ + V+ C S E CV+ PCP + D+ G
Sbjct: 696 SVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDF---G 752
Query: 980 SCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHEAVPCYSECNQY----SWVV 1035
CS+SCG G+R R E + + P + AQ + CN W V
Sbjct: 753 PCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQ--QPAVALETCNPQPCPARWEV 810
Query: 1036 EHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQSC-SLM 1094
SSC + G G CV ADG V + DE P + C +
Sbjct: 811 SEPSSC-------TSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMS 863
Query: 1095 CP-----------NECVMSEWG----------LWS----KCPQSCDPHTMQRR---TRHL 1126
CP E S WG +W+ C SC M+ R
Sbjct: 864 CPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSA 923
Query: 1127 LRPSLNSRTCA---------EDSQVQPCLLNENCFQFQYNLTEWSTCQLSENAPCGQGVR 1177
LR + C E Q PC ++QY L + C +S CG+GV
Sbjct: 924 LRVPVQEELCGLASKPGSRREVCQAVPCPA-----RWQYKL---AACSVS----CGRGVV 971
Query: 1178 TRLLSCVCS----DGKPVSMD-QCEQHNLEKPQRMSIPCLVECVVNCQLSGWTAWTECSQ 1232
R+L C + DG+ + +D QC+ L +P+ L C ++ + CS
Sbjct: 972 RRILYCARAHGEDDGEEILLDTQCQ--GLPRPEPQEACSLEPCPPRWKV---MSLGPCSA 1026
Query: 1233 TCGHGGRMSRTRFIIMPTQGEG-----RPCPTELTQEKT--CPVTPC-YSWVLGNWSACK 1284
+CG G R+ + QG+ C + E + C + C Y W +G W C
Sbjct: 1027 SCGL-GTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECS 1085
Query: 1285 LEGGDCGEGVQIRSLSCM 1302
+ CG+G+Q R +C+
Sbjct: 1086 V---SCGDGIQRRRDTCL 1100
Score = 55.1 bits (131), Expect = 5e-07
Identities = 123/498 (24%), Positives = 164/498 (32%), Gaps = 93/498 (18%)
Query: 691 TRPETVRPCFLPCKKDCIVTAFSEWTPCPRMCQAGNATVK-----QSRYRIIIQEAANGG 745
TRP+ F P + V A PC C AG V Q+R ++ G
Sbjct: 669 TRPDITFTYFQPKPRQAWVWAAVRG-PCSVSCGAGLRWVNYSCLDQARKELVETVQCQGS 727
Query: 746 QECPDTLYEERECEDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVS 805
Q+ P E + CP Y W + PC S +CG GL+ R V
Sbjct: 728 QQPPAW----PEACVLEPCPPY-WAVGDFGPC--------------SASCGGGLRERPVR 768
Query: 806 CISDDNRSAEMMECLKQTNG--MPLLVQECTVPCREDCTFTAWSKFTPCSTNCEATKSRR 863
C+ + + + G P + E P + C W P S C +
Sbjct: 769 CVEAQGSLLKTLPPARCRAGAQQPAVALETCNP--QPCP-ARWEVSEPSS--CTSAGG-- 821
Query: 864 RQLTGKSRKKEKC---QDSDLYPLVE-----TELCPCDE---FISQP--YGNWSDCILPE 910
G + + E C D P+ E E P E +S P +G+ E
Sbjct: 822 ---AGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGE 878
Query: 911 GRREPHRGLRVQAD------------SKECGEGLRFRAVACSDKNGR-PVDPSFC---SS 954
P +R A S CG GL C D R PV C S
Sbjct: 879 KAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASK 938
Query: 955 SGYIQEKC-VIPCPFDCKLSDWS-SWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDL 1012
G +E C +PCP + W +CS SCG GV R + +G ++ L
Sbjct: 939 PGSRREVCQAVPCP-----ARWQYKLAACSVSCGRGVVRRILYCARA--HGEDDGEEILL 991
Query: 1013 KNQAQ----VHEAVPCYSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTAD 1068
Q Q C E W V C S CG GT R + CV
Sbjct: 992 DTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPC-------SASCGLGTARRSVACVQLDQ 1044
Query: 1069 GEGGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEW--GLWSKCPQSCDPHTMQRRTRHL 1126
G+ VD C P + C + +C W G W +C SC +QRR
Sbjct: 1045 GQDVEVDEAACAALVRPEASVPCLIA---DCTY-RWHVGTWMECSVSCG-DGIQRRRDTC 1099
Query: 1127 LRPSLNSRTCAEDSQVQP 1144
L P + A+ Q P
Sbjct: 1100 LGPQAQAPVPADFCQHLP 1117
Score = 55.1 bits (131), Expect = 5e-07
Identities = 103/472 (21%), Positives = 159/472 (33%), Gaps = 109/472 (23%)
Query: 303 PKDCETSQWSSW-SPCSKTCRSGSLLPGF----RSRSRNVKHMAIGGGKECPELLEKEAC 357
PK + W++ PCS +C +G + ++R V+ + G ++ P EAC
Sbjct: 680 PKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAW--PEAC 737
Query: 358 IVEGELLQQCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPA 417
++E CP Y W ++ C S CGGG++ R V C ++ +
Sbjct: 738 VLE-----PCPPY-WAVGDFGPCSAS----------------CGGGLRERPVRCVEAQGS 775
Query: 418 A------AALRAKEVSRPVEKALCVGPAPLPSQ------------------LCNIPC--S 451
A RA V C P P P++ L N C
Sbjct: 776 LLKTLPPARCRAGAQQPAVALETC-NPQPCPARWEVSEPSSCTSAGGAGLALENETCVPG 834
Query: 452 TDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVESVPCEDPMC 511
D + + + + E P+ G +++T P S+
Sbjct: 835 ADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAA 894
Query: 512 YRWLASEGICFPDHGKCGLGHRILKAVCQNDRGE-DVSGSLCPVPPPP--ERKSCE-IPC 567
+ W + G C CG G L+ +C + V LC + P R+ C+ +PC
Sbjct: 895 HVWTPAAGSCSVS---CGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPC 951
Query: 568 RMDCVLSEWT-EWSSCSQSCSN---------KNSDGKQTRSRTILALAGEGGKPCPPSQA 617
+ W + ++CS SC + G+ +L +G P +A
Sbjct: 952 P-----ARWQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEA 1006
Query: 618 LQEHRLCNDHSCMQLHWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKS 677
C+ C W+ GPCS A+CG+G R V CV+
Sbjct: 1007 ------CSLEPCPP-RWKVMSLGPCS-----------------ASCGLGTARRSVACVQL 1042
Query: 678 HVGQ---VMTKRCPDSTRPETVRPCFLPCKKDCIVT-AFSEWTPCPRMCQAG 725
GQ V C RPE PC + DC W C C G
Sbjct: 1043 DQGQDVEVDEAACAALVRPEASVPCLI---ADCTYRWHVGTWMECSVSCGDG 1091
Score = 44.3 bits (103), Expect = 0.001
Identities = 56/248 (22%), Positives = 90/248 (36%), Gaps = 53/248 (21%)
Query: 637 SPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVG-QVMTKRCPDSTRPET 695
SPWG + + +CG G+ R C+ S + V + C +++P +
Sbjct: 882 SPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGS 941
Query: 696 VRPCFLPCKKDCIVTAFSEWTPCPRMCQAGNATVKQSRYRIIIQE----AANGGQECPDT 751
R + PCP Q A S R +++ A G++ +
Sbjct: 942 RREV-------------CQAVPCPARWQYKLAACSVSCGRGVVRRILYCARAHGEDDGEE 988
Query: 752 LYEERECE-----------DVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQ 800
+ + +C+ + CP RWK PC S +CG G
Sbjct: 989 ILLDTQCQGLPRPEPQEACSLEPCPP-RWKVMSLGPC--------------SASCGLGTA 1033
Query: 801 TRAVSCIS-DDNRSAEMMECLKQTNGMPLLVQECTVPCR-EDCTFTAW--SKFTPCSTNC 856
R+V+C+ D + E+ E L+ E +VPC DCT+ W + CS +C
Sbjct: 1034 RRSVACVQLDQGQDVEVDEAACAA----LVRPEASVPCLIADCTY-RWHVGTWMECSVSC 1088
Query: 857 EATKSRRR 864
RRR
Sbjct: 1089 GDGIQRRR 1096
Score = 41.6 bits (96), Expect = 0.006
Identities = 93/419 (22%), Positives = 139/419 (33%), Gaps = 91/419 (21%)
Query: 16 GPWGRCTGDCGPGGVQSRAVWCFHVDGW---TSHLSNCGESNRPPKERSCFRVCDWHSDL 72
G +G C+ CG GG++ R V C G T + C + P C+
Sbjct: 749 GDFGPCSASCG-GGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAV--ALETCNPQPCP 805
Query: 73 FQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHFA 132
+WEVS+ C A ++ T CV GL+ +
Sbjct: 806 ARWEVSEPSSCTSAGGAGLALENET--CVPGADGLEAPVT-------------------- 843
Query: 133 LQPPTEQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFG----GLQCPN 188
+ P +P P CV +C G G L + AP +G G Q +
Sbjct: 844 -EGPGSVDEKLPAPEPCV------GMSCPPGWGH-LDATSAGEKAPSPWGSIRTGAQAAH 895
Query: 189 LTESRACDAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDSNERVTF 248
+ A +SC G E F S R+P +E+ + + R
Sbjct: 896 VWTPAAGSCSVSCGRGLMELRFLCMD---SALRVPVQEELCGLA------SKPGSRREVC 946
Query: 249 KHQSYKAHHHSKSWAIEI----GYQTRQVSCTRS----DGQNAMLSL-CLQDSFPLTVQS 299
+ A K A + G R + C R+ DG+ +L C P ++
Sbjct: 947 QAVPCPARWQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEA 1006
Query: 300 CIMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKE-------CPELL 352
C + + S PCS +C G + R+V + + G++ C L+
Sbjct: 1007 CSLEPCPPRWKVMSLGPCSASC-------GLGTARRSVACVQLDQGQDVEVDEAACAALV 1059
Query: 353 EKEACIVEGELLQQCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYC 411
EA + L+ C Y W W EC VS CG GIQ R C
Sbjct: 1060 RPEASVPC--LIADCT-YRWHVGTWMECSVS----------------CGDGIQRRRDTC 1099
Score = 38.9 bits (89), Expect = 0.040
Identities = 37/158 (23%), Positives = 57/158 (36%), Gaps = 34/158 (21%)
Query: 662 TCGVGIQTRRVFCVKSHVGQ-----VMTKRCPDSTRPETVRPCFL-PCKKDCIVTAFSEW 715
+CG G+ R ++C ++H ++ +C RPE C L PC V +
Sbjct: 965 SCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLG-- 1022
Query: 716 TPCPRMCQAGNATVKQSRYR------IIIQEAANGGQECPDTLYEERECEDVSLCPVYRW 769
PC C G A + + + + EAA C + E + YRW
Sbjct: 1023 -PCSASCGLGTARRSVACVQLDQGQDVEVDEAA-----CAALVRPEASVPCLIADCTYRW 1076
Query: 770 KPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCI 807
W C S +CG G+Q R +C+
Sbjct: 1077 HVGTWMEC--------------SVSCGDGIQRRRDTCL 1100
Score = 35.8 bits (81), Expect = 0.34
Identities = 23/54 (42%), Positives = 27/54 (50%), Gaps = 6/54 (11%)
Query: 975 WSSWGS---CSSSCGIGVRIRSKWLKE-KPYNGGRPCPKLDLKNQAQVHEAVPC 1024
WSSWG CS SCG GV R + +P GGR C DL QA++ C
Sbjct: 387 WSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADL--QAEMCNTQAC 438
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 75.5 bits (184), Expect = 4e-13
Identities = 113/438 (25%), Positives = 164/438 (37%), Gaps = 93/438 (21%)
Query: 925 SKECGEGLRFRAVACSDKNGRP-VDPSFCSSSGYIQ---EKCVI-PCPFDCKLSDWSSWG 979
S CG GLR+ +C D+ + V+ C S E CV+ PCP + D+ G
Sbjct: 696 SVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDF---G 752
Query: 980 SCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHEAVPCYSECNQY----SWVV 1035
CS+SCG G+R R E + + P + AQ + CN W V
Sbjct: 753 PCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQ--QPAVALETCNPQPCPARWEV 810
Query: 1036 EHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQSC-SLM 1094
SSC + G G CV ADG V + DE P + C +
Sbjct: 811 SEPSSC-------TSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMS 863
Query: 1095 CP-----------NECVMSEWG----------LWS----KCPQSCDPHTMQRR---TRHL 1126
CP E S WG +W+ C SC M+ R
Sbjct: 864 CPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSA 923
Query: 1127 LRPSLNSRTCA---------EDSQVQPCLLNENCFQFQYNLTEWSTCQLSENAPCGQGVR 1177
LR + C E Q PC ++QY L + C +S CG+GV
Sbjct: 924 LRVPVQEELCGLASKPGSRREVCQAVPCPA-----RWQYKL---AACSVS----CGRGVV 971
Query: 1178 TRLLSCVCS----DGKPVSMD-QCEQHNLEKPQRMSIPCLVECVVNCQLSGWTAWTECSQ 1232
R+L C + DG+ + +D QC+ L +P+ L C ++ + CS
Sbjct: 972 RRILYCARAHGEDDGEEILLDTQCQ--GLPRPEPQEACSLEPCPPRWKV---MSLGPCSA 1026
Query: 1233 TCGHGGRMSRTRFIIMPTQGEG-----RPCPTELTQEKT--CPVTPC-YSWVLGNWSACK 1284
+CG G R+ + QG+ C + E + C + C Y W +G W C
Sbjct: 1027 SCGL-GTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECS 1085
Query: 1285 LEGGDCGEGVQIRSLSCM 1302
+ CG+G+Q R +C+
Sbjct: 1086 V---SCGDGIQRRRDTCL 1100
Score = 55.1 bits (131), Expect = 5e-07
Identities = 123/498 (24%), Positives = 164/498 (32%), Gaps = 93/498 (18%)
Query: 691 TRPETVRPCFLPCKKDCIVTAFSEWTPCPRMCQAGNATVK-----QSRYRIIIQEAANGG 745
TRP+ F P + V A PC C AG V Q+R ++ G
Sbjct: 669 TRPDITFTYFQPKPRQAWVWAAVRG-PCSVSCGAGLRWVNYSCLDQARKELVETVQCQGS 727
Query: 746 QECPDTLYEERECEDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVS 805
Q+ P E + CP Y W + PC S +CG GL+ R V
Sbjct: 728 QQPPAW----PEACVLEPCPPY-WAVGDFGPC--------------SASCGGGLRERPVR 768
Query: 806 CISDDNRSAEMMECLKQTNG--MPLLVQECTVPCREDCTFTAWSKFTPCSTNCEATKSRR 863
C+ + + + G P + E P + C W P S C +
Sbjct: 769 CVEAQGSLLKTLPPARCRAGAQQPAVALETCNP--QPCP-ARWEVSEPSS--CTSAGG-- 821
Query: 864 RQLTGKSRKKEKC---QDSDLYPLVE-----TELCPCDE---FISQP--YGNWSDCILPE 910
G + + E C D P+ E E P E +S P +G+ E
Sbjct: 822 ---AGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGE 878
Query: 911 GRREPHRGLRVQAD------------SKECGEGLRFRAVACSDKNGR-PVDPSFC---SS 954
P +R A S CG GL C D R PV C S
Sbjct: 879 KAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASK 938
Query: 955 SGYIQEKC-VIPCPFDCKLSDWS-SWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDL 1012
G +E C +PCP + W +CS SCG GV R + +G ++ L
Sbjct: 939 PGSRREVCQAVPCP-----ARWQYKLAACSVSCGRGVVRRILYCARA--HGEDDGEEILL 991
Query: 1013 KNQAQ----VHEAVPCYSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTAD 1068
Q Q C E W V C S CG GT R + CV
Sbjct: 992 DTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPC-------SASCGLGTARRSVACVQLDQ 1044
Query: 1069 GEGGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEW--GLWSKCPQSCDPHTMQRRTRHL 1126
G+ VD C P + C + +C W G W +C SC +QRR
Sbjct: 1045 GQDVEVDEAACAALVRPEASVPCLIA---DCTY-RWHVGTWMECSVSCG-DGIQRRRDTC 1099
Query: 1127 LRPSLNSRTCAEDSQVQP 1144
L P + A+ Q P
Sbjct: 1100 LGPQAQAPVPADFCQHLP 1117
Score = 55.1 bits (131), Expect = 5e-07
Identities = 103/472 (21%), Positives = 159/472 (33%), Gaps = 109/472 (23%)
Query: 303 PKDCETSQWSSW-SPCSKTCRSGSLLPGF----RSRSRNVKHMAIGGGKECPELLEKEAC 357
PK + W++ PCS +C +G + ++R V+ + G ++ P EAC
Sbjct: 680 PKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAW--PEAC 737
Query: 358 IVEGELLQQCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPA 417
++E CP Y W ++ C S CGGG++ R V C ++ +
Sbjct: 738 VLE-----PCPPY-WAVGDFGPCSAS----------------CGGGLRERPVRCVEAQGS 775
Query: 418 A------AALRAKEVSRPVEKALCVGPAPLPSQ------------------LCNIPC--S 451
A RA V C P P P++ L N C
Sbjct: 776 LLKTLPPARCRAGAQQPAVALETC-NPQPCPARWEVSEPSSCTSAGGAGLALENETCVPG 834
Query: 452 TDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVESVPCEDPMC 511
D + + + + E P+ G +++T P S+
Sbjct: 835 ADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAA 894
Query: 512 YRWLASEGICFPDHGKCGLGHRILKAVCQNDRGE-DVSGSLCPVPPPP--ERKSCE-IPC 567
+ W + G C CG G L+ +C + V LC + P R+ C+ +PC
Sbjct: 895 HVWTPAAGSCSVS---CGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPC 951
Query: 568 RMDCVLSEWT-EWSSCSQSCSN---------KNSDGKQTRSRTILALAGEGGKPCPPSQA 617
+ W + ++CS SC + G+ +L +G P +A
Sbjct: 952 P-----ARWQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEA 1006
Query: 618 LQEHRLCNDHSCMQLHWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKS 677
C+ C W+ GPCS A+CG+G R V CV+
Sbjct: 1007 ------CSLEPCPP-RWKVMSLGPCS-----------------ASCGLGTARRSVACVQL 1042
Query: 678 HVGQ---VMTKRCPDSTRPETVRPCFLPCKKDCIVT-AFSEWTPCPRMCQAG 725
GQ V C RPE PC + DC W C C G
Sbjct: 1043 DQGQDVEVDEAACAALVRPEASVPCLI---ADCTYRWHVGTWMECSVSCGDG 1091
Score = 44.3 bits (103), Expect = 0.001
Identities = 56/248 (22%), Positives = 90/248 (36%), Gaps = 53/248 (21%)
Query: 637 SPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVG-QVMTKRCPDSTRPET 695
SPWG + + +CG G+ R C+ S + V + C +++P +
Sbjct: 882 SPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGS 941
Query: 696 VRPCFLPCKKDCIVTAFSEWTPCPRMCQAGNATVKQSRYRIIIQE----AANGGQECPDT 751
R + PCP Q A S R +++ A G++ +
Sbjct: 942 RREV-------------CQAVPCPARWQYKLAACSVSCGRGVVRRILYCARAHGEDDGEE 988
Query: 752 LYEERECE-----------DVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQ 800
+ + +C+ + CP RWK PC S +CG G
Sbjct: 989 ILLDTQCQGLPRPEPQEACSLEPCPP-RWKVMSLGPC--------------SASCGLGTA 1033
Query: 801 TRAVSCIS-DDNRSAEMMECLKQTNGMPLLVQECTVPCR-EDCTFTAW--SKFTPCSTNC 856
R+V+C+ D + E+ E L+ E +VPC DCT+ W + CS +C
Sbjct: 1034 RRSVACVQLDQGQDVEVDEAACAA----LVRPEASVPCLIADCTY-RWHVGTWMECSVSC 1088
Query: 857 EATKSRRR 864
RRR
Sbjct: 1089 GDGIQRRR 1096
Score = 41.6 bits (96), Expect = 0.006
Identities = 93/419 (22%), Positives = 139/419 (33%), Gaps = 91/419 (21%)
Query: 16 GPWGRCTGDCGPGGVQSRAVWCFHVDGW---TSHLSNCGESNRPPKERSCFRVCDWHSDL 72
G +G C+ CG GG++ R V C G T + C + P C+
Sbjct: 749 GDFGPCSASCG-GGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAV--ALETCNPQPCP 805
Query: 73 FQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHFA 132
+WEVS+ C A ++ T CV GL+ +
Sbjct: 806 ARWEVSEPSSCTSAGGAGLALENET--CVPGADGLEAPVT-------------------- 843
Query: 133 LQPPTEQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFG----GLQCPN 188
+ P +P P CV +C G G L + AP +G G Q +
Sbjct: 844 -EGPGSVDEKLPAPEPCV------GMSCPPGWGH-LDATSAGEKAPSPWGSIRTGAQAAH 895
Query: 189 LTESRACDAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDSNERVTF 248
+ A +SC G E F S R+P +E+ + + R
Sbjct: 896 VWTPAAGSCSVSCGRGLMELRFLCMD---SALRVPVQEELCGLA------SKPGSRREVC 946
Query: 249 KHQSYKAHHHSKSWAIEI----GYQTRQVSCTRS----DGQNAMLSL-CLQDSFPLTVQS 299
+ A K A + G R + C R+ DG+ +L C P ++
Sbjct: 947 QAVPCPARWQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEA 1006
Query: 300 CIMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKE-------CPELL 352
C + + S PCS +C G + R+V + + G++ C L+
Sbjct: 1007 CSLEPCPPRWKVMSLGPCSASC-------GLGTARRSVACVQLDQGQDVEVDEAACAALV 1059
Query: 353 EKEACIVEGELLQQCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYC 411
EA + L+ C Y W W EC VS CG GIQ R C
Sbjct: 1060 RPEASVPC--LIADCT-YRWHVGTWMECSVS----------------CGDGIQRRRDTC 1099
Score = 38.9 bits (89), Expect = 0.040
Identities = 37/158 (23%), Positives = 57/158 (36%), Gaps = 34/158 (21%)
Query: 662 TCGVGIQTRRVFCVKSHVGQ-----VMTKRCPDSTRPETVRPCFL-PCKKDCIVTAFSEW 715
+CG G+ R ++C ++H ++ +C RPE C L PC V +
Sbjct: 965 SCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLG-- 1022
Query: 716 TPCPRMCQAGNATVKQSRYR------IIIQEAANGGQECPDTLYEERECEDVSLCPVYRW 769
PC C G A + + + + EAA C + E + YRW
Sbjct: 1023 -PCSASCGLGTARRSVACVQLDQGQDVEVDEAA-----CAALVRPEASVPCLIADCTYRW 1076
Query: 770 KPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCI 807
W C S +CG G+Q R +C+
Sbjct: 1077 HVGTWMEC--------------SVSCGDGIQRRRDTCL 1100
Score = 35.8 bits (81), Expect = 0.34
Identities = 23/54 (42%), Positives = 27/54 (50%), Gaps = 6/54 (11%)
Query: 975 WSSWGS---CSSSCGIGVRIRSKWLKE-KPYNGGRPCPKLDLKNQAQVHEAVPC 1024
WSSWG CS SCG GV R + +P GGR C DL QA++ C
Sbjct: 387 WSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADL--QAEMCNTQAC 438
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1 motif,
17 preproprotein [Homo sapiens]
Length = 1095
Score = 75.5 bits (184), Expect = 4e-13
Identities = 72/242 (29%), Positives = 88/242 (36%), Gaps = 55/242 (22%)
Query: 576 WTE--WSSCSQSCSNKNSDGKQTRSRTILALAG-EGGKPCPP-SQALQEHRLCNDHSCMQ 631
WT W CS C + +R + CP S+ + R CN H C Q
Sbjct: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPC-Q 862
Query: 632 LHWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVK-----SHVGQVMTKR 686
W PW PCS ATC G Q R V CV +HV
Sbjct: 863 SRWVAGPWSPCS-----------------ATCEKGFQHREVTCVYQLQNGTHVA-TRPLY 904
Query: 687 CPDSTRPETVRPCFLPCKKDCI-VTAFSEWTPCPRMCQAGNATVKQSRYRIIIQEAANGG 745
CP RP V+ C +DC+ + SEW+ C C G K R + + G
Sbjct: 905 CP-GPRPAAVQSCE---GQDCLSIWEASEWSQCSASC--GKGVWK----RTVACTNSQGK 954
Query: 746 QECPDTLYEERECEDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVS 805
+ E CED S C Y WK WS C S CGKGLQ+R V
Sbjct: 955 CDASTRPRAEEACEDYSGC--YEWKTGDWSTC--------------SSTCGKGLQSRVVQ 998
Query: 806 CI 807
C+
Sbjct: 999 CM 1000
Score = 72.0 bits (175), Expect = 4e-12
Identities = 64/203 (31%), Positives = 84/203 (41%), Gaps = 45/203 (22%)
Query: 505 PCEDPMCYRWLASEGICFPDHGKC--GLGHRILKAVCQNDRGEDVSGS--LCPVPPPPER 560
PC+ RW+A G P C G HR + V Q G V+ CP P P
Sbjct: 860 PCQS----RWVA--GPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAV 913
Query: 561 KSCEIPCRMDCVLSEW--TEWSSCSQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQAL 618
+SCE DC LS W +EWS CS SC GK RT+ +G C S
Sbjct: 914 QSCE---GQDC-LSIWEASEWSQCSASC------GKGVWKRTVACTNSQG--KCDASTRP 961
Query: 619 QEHRLCNDHS-CMQLHWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKS 677
+ C D+S C + W+T W CS +TCG G+Q+R V C+
Sbjct: 962 RAEEACEDYSGCYE--WKTGDWSTCS-----------------STCGKGLQSRVVQCMHK 1002
Query: 678 HVGQVMTKRCPDSTRPETVRPCF 700
G+ CP ++P R C+
Sbjct: 1003 VTGR-HGSECPALSKPAPYRQCY 1024
Score = 69.7 bits (169), Expect = 2e-11
Identities = 65/280 (23%), Positives = 105/280 (37%), Gaps = 54/280 (19%)
Query: 1014 NQAQVHEAVPCYSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGA 1073
N+ +++ P + + + W W C S++CGGG + + C +
Sbjct: 785 NRTAENQSEPEKPQDSLFIWTHSGWEGC-------SVQCGGGERRTIVSCTRIVNKTTTL 837
Query: 1074 VDSNLCNQDEIP-PETQSCSLMCPNECVMSEW--GLWSKCPQSCDPHTMQRRTRHLLRPS 1130
V+ + C Q P P+ + C+L + C S W G WS C +C+ R + +
Sbjct: 838 VNDSDCPQASRPEPQVRRCNL---HPC-QSRWVAGPWSPCSATCEKGFQHREVTCVYQLQ 893
Query: 1131 LNSRTCAED--------SQVQPCLLNENCFQFQYNLTEWSTCQLSENAPCGQGVRTRLLS 1182
+ + VQ C ++C + +EWS C +A CG+GV R ++
Sbjct: 894 NGTHVATRPLYCPGPRPAAVQSCE-GQDCLSI-WEASEWSQC----SASCGKGVWKRTVA 947
Query: 1183 CVCSDGK------PVSMDQCEQHNLEKPQRMSIPCLVECVVNCQLSGWTAWTECSQTCGH 1236
C S GK P + + CE ++ C W+ CS TCG
Sbjct: 948 CTNSQGKCDASTRPRAEEACEDYS-----------------GCYEWKTGDWSTCSSTCGK 990
Query: 1237 GGRMSRTRFIIMPTQGEGRPCPTELTQEKTCPVTPCYSWV 1276
G + + + T G CP K P CY V
Sbjct: 991 GLQSRVVQCMHKVTGRHGSECP---ALSKPAPYRQCYQEV 1027
Score = 62.4 bits (150), Expect = 3e-09
Identities = 62/213 (29%), Positives = 86/213 (40%), Gaps = 47/213 (22%)
Query: 18 WGRCTGDCGPGGVQSRAVWCFHVDGWTSHL---SNCGESNRPPKERSCFRVCDWHSDLFQ 74
W C+ CG GG + V C + T+ L S+C +++RP + R C+ H +
Sbjct: 809 WEGCSVQCG-GGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQ---VRRCNLHPCQSR 864
Query: 75 WEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKL-NRTVVANEICEHFAL 133
W W C T + G QHR V C+ +L N T VA
Sbjct: 865 WVAGPWSPC----------------SATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGP 908
Query: 134 QPPTEQACLIPCPRDCV-VSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPNLTES 192
+P Q+C +DC+ + E WS CS CGK + RT A C N
Sbjct: 909 RPAAVQSCE---GQDCLSIWEASEWSQCSASCGKGVWKRTVA-----------CTN--SQ 952
Query: 193 RACDAPISCPLGE---EEYT--FSLKVGPWSKC 220
CDA + P E E+Y+ + K G WS C
Sbjct: 953 GKCDAS-TRPRAEEACEDYSGCYEWKTGDWSTC 984
Score = 58.9 bits (141), Expect = 4e-08
Identities = 48/155 (30%), Positives = 64/155 (41%), Gaps = 25/155 (16%)
Query: 925 SKECGEGLRFRAVAC--SDKNGRPVD--PSFCSSSGYIQEKCVIPCPFDCKLSDW--SSW 978
S C +G + R V C +NG V P +C + V C LS W S W
Sbjct: 874 SATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGP---RPAAVQSCEGQDCLSIWEASEW 930
Query: 979 GSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHEAVPCYSECNQYSWVVEHW 1038
CS+SCG GV W + + K D + + EA YS C Y W W
Sbjct: 931 SQCSASCGKGV-----WKRTVACTNSQ--GKCDASTRPRAEEACEDYSGC--YEWKTGDW 981
Query: 1039 SSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGA 1073
S+C S CG G QSR ++C++ G G+
Sbjct: 982 STC-------SSTCGKGLQSRVVQCMHKVTGRHGS 1009
Score = 56.2 bits (134), Expect = 2e-07
Identities = 64/274 (23%), Positives = 102/274 (37%), Gaps = 45/274 (16%)
Query: 976 SSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHEAVPCYSECN----QY 1031
S W CS CG G R + + + ++ + Q P CN Q
Sbjct: 807 SGWEGCSVQCGGGER---RTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQS 863
Query: 1032 SWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQSC 1091
WV WS C S C G Q R++ CV L P QSC
Sbjct: 864 RWVAGPWSPC-------SATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSC 916
Query: 1092 SLMCPNECV-MSEWGLWSKCPQSCDPHTMQRR---TRHLLRPSLNSRTCAEDSQVQPCLL 1147
+C+ + E WS+C SC +R T + ++R AE++ C
Sbjct: 917 E---GQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDASTRPRAEEA----CED 969
Query: 1148 NENCFQFQYNLTEWSTCQLSENAPCGQGVRTRLLSCV----------C-SDGKPVSMDQC 1196
C++++ +WSTC ++ CG+G+++R++ C+ C + KP QC
Sbjct: 970 YSGCYEWKTG--DWSTC----SSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQC 1023
Query: 1197 EQ---HNLEKPQRMSIPCLVECVVNCQLSGWTAW 1227
Q ++ ++ P L C WT +
Sbjct: 1024 YQEVCNDRINANTITSPRLAALTYKCTRDQWTVY 1057
Score = 53.9 bits (128), Expect = 1e-06
Identities = 52/219 (23%), Positives = 79/219 (36%), Gaps = 41/219 (18%)
Query: 1154 FQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSM---DQCEQHNLEKPQRMSIP 1210
F + + W C + CG G R ++SC K ++ C Q + +PQ
Sbjct: 802 FIWTHSGWEGCSVQ----CGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQ----- 852
Query: 1211 CLVECVVNCQLSGWTA--WTECSQTCGHGGRMSRTRFIIMPTQGEG---RP--CP-TELT 1262
+ C ++ S W A W+ CS TC G + + G RP CP
Sbjct: 853 -VRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPA 911
Query: 1263 QEKTCPVTPCYS-WVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCG 1321
++C C S W WS C CG+GV R+++C G + + C
Sbjct: 912 AVQSCEGQDCLSIWEASEWSQCS---ASCGKGVWKRTVACTNSQGKCDASTRPRAEEACE 968
Query: 1322 EMPFQDSILKQLCSVPCPGDCHLTEWSEWSTCELTCIDG 1360
+ C+ + +WSTC TC G
Sbjct: 969 DY----------------SGCYEWKTGDWSTCSSTCGKG 991
Score = 51.6 bits (122), Expect = 6e-06
Identities = 46/170 (27%), Positives = 64/170 (37%), Gaps = 36/170 (21%)
Query: 656 GWNG-EATCGVGIQTRRVFC---VKSHVGQVMTKRCPDSTRPET-VRPCFL-PCKKDCIV 709
GW G CG G + V C V V CP ++RPE VR C L PC+ +
Sbjct: 808 GWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVA 867
Query: 710 TAFSEWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQECPDTLY-------EERECEDVS 762
W+PC C+ G Q R + + NG LY + CE
Sbjct: 868 ---GPWSPCSATCEKGF----QHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQD 920
Query: 763 LCPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCISDDNR 812
+ W+ +WS C S +CGKG+ R V+C + +
Sbjct: 921 CLSI--WEASEWSQC--------------SASCGKGVWKRTVACTNSQGK 954
Score = 47.4 bits (111), Expect = 1e-04
Identities = 60/242 (24%), Positives = 93/242 (38%), Gaps = 45/242 (18%)
Query: 784 VW--QGITGSSEACGKGLQTRAVSCISDDNRSAEMM---ECLKQTNGMPLLVQECTV-PC 837
+W G G S CG G + VSC N++ ++ +C + + P V+ C + PC
Sbjct: 803 IWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEP-QVRRCNLHPC 861
Query: 838 REDCTFTAWSKFTPCSTNCEATKSRRR-----QLTGKSRKKEKCQDSDLYPLVETELCPC 892
+ WS PCS CE R QL + + + C
Sbjct: 862 QSRWVAGPWS---PCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEG 918
Query: 893 DEFIS-QPYGNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSDKNGRPVDPSF 951
+ +S WS C S CG+G+ R VAC++ G+
Sbjct: 919 QDCLSIWEASEWSQC------------------SASCGKGVWKRTVACTNSQGK----CD 956
Query: 952 CSSSGYIQEKC--VIPCPFDCKLSDWSSWGSCSSSCGIGVRIR-SKWLKEKPYNGGRPCP 1008
S+ +E C C ++ K DWS +CSS+CG G++ R + + + G CP
Sbjct: 957 ASTRPRAEEACEDYSGC-YEWKTGDWS---TCSSTCGKGLQSRVVQCMHKVTGRHGSECP 1012
Query: 1009 KL 1010
L
Sbjct: 1013 AL 1014
Score = 47.4 bits (111), Expect = 1e-04
Identities = 30/104 (28%), Positives = 43/104 (41%), Gaps = 27/104 (25%)
Query: 15 AGPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFRVCDWHSDLFQ 74
A W +C+ CG G V R V C + G C S RP E +C + +S ++
Sbjct: 927 ASEWSQCSASCGKG-VWKRTVACTNSQG------KCDASTRPRAEEAC----EDYSGCYE 975
Query: 75 WEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKL 118
W+ DW C T GLQ R+V+C+ K+
Sbjct: 976 WKTGDWSTC----------------SSTCGKGLQSRVVQCMHKV 1003
Score = 47.0 bits (110), Expect = 1e-04
Identities = 68/291 (23%), Positives = 91/291 (31%), Gaps = 88/291 (30%)
Query: 72 LFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRT--VVANEICE 129
LF W S W C V G + +V C + +N+T +V + C
Sbjct: 801 LFIWTHSGWEGC----------------SVQCGGGERRTIVSCTRIVNKTTTLVNDSDCP 844
Query: 130 HFALQPPTEQAC-LIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFG------ 182
+ P + C L PC V PWS CS C K QHR + G
Sbjct: 845 QASRPEPQVRRCNLHPCQSRWVAG---PWSPCSATCEKGFQHREVTCVYQLQNGTHVATR 901
Query: 183 GLQCPNLTESRACDAPISCPLGEEEYTFSL-KVGPWSKCRLPHLKEINPSGRTVLDFNSD 241
L CP P + E + S+ + WS+C
Sbjct: 902 PLYCPG-------PRPAAVQSCEGQDCLSIWEASEWSQC--------------------- 933
Query: 242 SNERVTFKHQSYKAHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCI 301
S + G R V+CT S G+ C + P ++C
Sbjct: 934 -------------------SASCGKGVWKRTVACTNSQGK------CDASTRPRAEEACE 968
Query: 302 MPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIG-GGKECPEL 351
C + WS CS TC G +SR H G G ECP L
Sbjct: 969 DYSGCYEWKTGDWSTCSSTCGK-----GLQSRVVQCMHKVTGRHGSECPAL 1014
Score = 46.2 bits (108), Expect = 2e-04
Identities = 29/93 (31%), Positives = 41/93 (44%), Gaps = 8/93 (8%)
Query: 938 ACSDKNGRPVDPSFCSS-----SGYIQEKCVIPCPFDCKLSDWSSWGSCSSSCGIGVRIR 992
+C K P+D + C + +G K IP D S W +W CS +CG G R R
Sbjct: 507 SCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFR 566
Query: 993 SKWLKEKPYN-GGRPCPKLDLKNQAQVHEAVPC 1024
+ P GG CP +++ V E +PC
Sbjct: 567 QRKCDNPPPGPGGTHCPGASVEH--AVCENLPC 597
Score = 45.4 bits (106), Expect = 4e-04
Identities = 42/158 (26%), Positives = 60/158 (37%), Gaps = 28/158 (17%)
Query: 14 LAGPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFRVCDWHSDLF 73
+AGPW C+ C G Q R V C + +H++ P + + C+ L
Sbjct: 866 VAGPWSPCSATCEKG-FQHREVTCVYQLQNGTHVAT-RPLYCPGPRPAAVQSCEGQDCLS 923
Query: 74 QWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHFAL 133
WE S+W C +A C G+ R V C + C+ +
Sbjct: 924 IWEASEWSQC-------------SASC---GKGVWKRTVACTNSQGK-------CDA-ST 959
Query: 134 QPPTEQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHR 171
+P E+AC C + WS CS CGK LQ R
Sbjct: 960 RPRAEEAC--EDYSGCYEWKTGDWSTCSSTCGKGLQSR 995
Score = 45.1 bits (105), Expect = 6e-04
Identities = 51/198 (25%), Positives = 72/198 (36%), Gaps = 41/198 (20%)
Query: 265 EIGYQTRQVSCT---RSDGQNAMLSLCLQDSFPLTVQSCIMPKDCETSQW--SSWSPCSK 319
E G+Q R+V+C ++ A L P VQSC +DC S W S WS CS
Sbjct: 878 EKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSC-EGQDC-LSIWEASEWSQCSA 935
Query: 320 TCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEGELLQQCPRYSWRTSEWKE 379
+C G + K A + +EAC E C Y W+T +W
Sbjct: 936 SCGKGVWKRTVACTNSQGKCDASTRPRA------EEAC----EDYSGC--YEWKTGDWST 983
Query: 380 CQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKALCVGPA 439
C + CG G+Q+R V C V +S+P C
Sbjct: 984 CSST----------------CGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCY--- 1024
Query: 440 PLPSQLCNIPCSTDCIVS 457
++CN + + I S
Sbjct: 1025 ---QEVCNDRINANTITS 1039
Score = 40.8 bits (94), Expect = 0.010
Identities = 18/51 (35%), Positives = 23/51 (45%)
Query: 1222 SGWTAWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPTELTQEKTCPVTPC 1272
S W AW+ CS+TCG G R + + P G CP + C PC
Sbjct: 547 SPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPC 597
Score = 38.9 bits (89), Expect = 0.040
Identities = 23/59 (38%), Positives = 30/59 (50%), Gaps = 5/59 (8%)
Query: 11 YHKLAGPWGRCTGDCGPGGVQSRAVWCFH-VDGWTSHLSNCGESNRPPKERSCFR-VCD 67
Y G W C+ CG G+QSR V C H V G H S C ++P R C++ VC+
Sbjct: 974 YEWKTGDWSTCSSTCGK-GLQSRVVQCMHKVTG--RHGSECPALSKPAPYRQCYQEVCN 1029
Score = 35.8 bits (81), Expect = 0.34
Identities = 29/85 (34%), Positives = 34/85 (40%), Gaps = 15/85 (17%)
Query: 435 CVGPAPLPSQLCNIPCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPA 494
CV P+P + D S W AW +C C G R RQR GP
Sbjct: 532 CVSKTPIPEHV-------DGDWSPWGAWSMC-SRTC-----GTGARFRQRKCDNPPPGPG 578
Query: 495 G-HCPHL-VESVPCEDPMCYRWLAS 517
G HCP VE CE+ C + L S
Sbjct: 579 GTHCPGASVEHAVCENLPCPKGLPS 603
Score = 34.7 bits (78), Expect = 0.75
Identities = 18/49 (36%), Positives = 22/49 (44%), Gaps = 1/49 (2%)
Query: 157 WSNCSKGCGKKLQHRTRAVIAPPLF-GGLQCPNLTESRACDAPISCPLG 204
WS CS+ CG + R R PP GG CP + A + CP G
Sbjct: 552 WSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKG 600
Score = 34.3 bits (77), Expect = 0.98
Identities = 18/46 (39%), Positives = 24/46 (52%), Gaps = 6/46 (13%)
Query: 305 DCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIG-GGKECP 349
D + S W +WS CS+TC +G+ R R R + G GG CP
Sbjct: 543 DGDWSPWGAWSMCSRTCGTGA-----RFRQRKCDNPPPGPGGTHCP 583
Score = 33.9 bits (76), Expect = 1.3
Identities = 22/66 (33%), Positives = 29/66 (43%), Gaps = 7/66 (10%)
Query: 565 IPCRMDCVLSEWTEWSSCSQSCSNKNSDGKQTRSRTI-LALAGEGGKPCPPSQALQEHRL 623
IP +D S W WS CS++C G + R R G GG CP + EH +
Sbjct: 538 IPEHVDGDWSPWGAWSMCSRTCGT----GARFRQRKCDNPPPGPGGTHCPGASV--EHAV 591
Query: 624 CNDHSC 629
C + C
Sbjct: 592 CENLPC 597
>gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [Homo
sapiens]
Length = 1584
Score = 75.1 bits (183), Expect = 5e-13
Identities = 82/336 (24%), Positives = 118/336 (35%), Gaps = 66/336 (19%)
Query: 975 WSSWGSCSSSCGIGVRIRSKWLKEKP----------YNGGRPC------PKLDLKNQAQV 1018
WS WG C+ CG G++ R++ P GR C P +++Q
Sbjct: 267 WSLWGECTRDCGGGLQTRTRTCLPAPGVEGGGCEGVLEEGRQCNREACGPAGRTSSRSQS 326
Query: 1019 HEAVPCY------SECNQYSW--------VVEHWSSCKINNELRSLRCGGGTQSRKIRCV 1064
+ E Q+ + E WS + S CG G Q+R CV
Sbjct: 327 LRSTDARRREELGDELQQFGFPAPQTGDPAAEEWSPWSVC----SSTCGEGWQTRTRFCV 382
Query: 1065 NTADG---EGGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEWGLWSKCPQSCDPHTMQR 1121
+++ G + LCN S +CP EW WS C +C +
Sbjct: 383 SSSYSTQCSGPLREQRLCNN----------SAVCPVHGAWDEWSPWSLCSSTCG-RGFRD 431
Query: 1122 RTRHLLRPSLNSRTC-AEDSQVQPC---LLNENCFQFQYN-LTEWSTCQLSENAPCGQGV 1176
RTR P C + Q + C L +N + WS C +A C QG
Sbjct: 432 RTRTCRPPQFGGNPCEGPEKQTKFCNIALCPGRAVDGNWNEWSSWSAC----SASCSQGR 487
Query: 1177 RTRLLSCVCSDGKPVSMDQCEQHNLEKPQRMSIPCLVECVVNCQLSGWTAWTECSQTCGH 1236
+ R C +G +C+ H +E L +C V+ + W +W CS TCG
Sbjct: 488 QQRTREC---NGPSYGGAECQGHWVETRDCF----LQQCPVDGKWQAWASWGSCSVTCG- 539
Query: 1237 GGRMSRTRFIIMPTQGEGRPCPTELTQEKTCPVTPC 1272
G R R P G G C + + C C
Sbjct: 540 AGSQRRERVCSGPFFG-GAACQGPQDEYRQCGTQRC 574
Score = 72.0 bits (175), Expect = 4e-12
Identities = 89/371 (23%), Positives = 134/371 (36%), Gaps = 71/371 (19%)
Query: 1104 WGLWSKCPQSCDPHTMQRRTRHLLRPSLNSRTCAEDSQVQPCLLNENCFQFQYNLTEWST 1163
W LW +C + C R L P + C + L E
Sbjct: 267 WSLWGECTRDCGGGLQTRTRTCLPAPGVEGGGC------------------EGVLEEGRQ 308
Query: 1164 CQLSENAPCGQ-GVRTRLLSCVCSDGKPVSMDQCEQHNLEKPQRMSIPCLVECVVNCQLS 1222
C P G+ R++ L + + D+ +Q PQ P E
Sbjct: 309 CNREACGPAGRTSSRSQSLRSTDARRREELGDELQQFGFPAPQTGD-PAAEE-------- 359
Query: 1223 GWTAWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPTELTQEKTC---PVTPCY-SWVLG 1278
W+ W+ CS TCG G + +RTRF + + C L +++ C V P + +W
Sbjct: 360 -WSPWSVCSSTCGEGWQ-TRTRFCV--SSSYSTQCSGPLREQRLCNNSAVCPVHGAW--D 413
Query: 1279 NWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSILKQLCSVP- 1337
WS L CG G + R+ +C + G + + C++
Sbjct: 414 EWSPWSLCSSTCGRGFRDRTRTCRPPQFGGNPCEGPEKQT-------------KFCNIAL 460
Query: 1338 CPG---DCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQSFENQDSCPQQVLETR 1394
CPG D + EWS WS C +C + GRQ R+R S+ + C +ETR
Sbjct: 461 CPGRAVDGNWNEWSSWSACSASC-------SQGRQQRTRECNGPSYGGAE-CQGHWVETR 512
Query: 1395 PCTGGKC-YHYTWKA-SLWNNNERT--VWCQRSDGV---NVTGGCSPQARPAAIRQC-IP 1446
C +C W+A + W + T QR + V GG + Q RQC
Sbjct: 513 DCFLQQCPVDGKWQAWASWGSCSVTCGAGSQRRERVCSGPFFGGAACQGPQDEYRQCGTQ 572
Query: 1447 ACRKPFSYCTQ 1457
C +P C +
Sbjct: 573 RCPEPHEICDE 583
Score = 65.9 bits (159), Expect = 3e-10
Identities = 83/373 (22%), Positives = 120/373 (32%), Gaps = 67/373 (17%)
Query: 712 FSEWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQECPDTLYEERECEDVSLCPVYRWK- 770
+S W C R C G Q+R R + G C L E R+C + P R
Sbjct: 267 WSLWGECTRDCGGG----LQTRTRTCLPAPGVEGGGCEGVLEEGRQCNREACGPAGRTSS 322
Query: 771 ---------------------------PQKWSPCILVPESVWQGITGSSEACGKGLQTRA 803
PQ P W + S CG+G QTR
Sbjct: 323 RSQSLRSTDARRREELGDELQQFGFPAPQTGDPAA----EEWSPWSVCSSTCGEGWQTRT 378
Query: 804 VSCISDDNRSAEMMECLKQTNGMPLLVQECTVPCREDCTFTAWSKFTPCSTNC-EATKSR 862
C+S S+ +C L P + WS ++ CS+ C + R
Sbjct: 379 RFCVS----SSYSTQCSGPLREQRLCNNSAVCPVHG--AWDEWSPWSLCSSTCGRGFRDR 432
Query: 863 RRQLTGKSRKKEKCQDSDLYP-LVETELCPCDEFISQPYGNWSDCILPEGRREPHRGLRV 921
R C+ + LCP + + WS
Sbjct: 433 TRTCRPPQFGGNPCEGPEKQTKFCNIALCP-GRAVDGNWNEWSSW--------------- 476
Query: 922 QADSKECGEGLRFRAVACSDKNGRPVDPSFCSSSGYIQEKCVIP-CPFDCKLSDWSSWGS 980
A S C +G + R C NG + C C + CP D K W+SWGS
Sbjct: 477 SACSASCSQGRQQRTREC---NGPSYGGAECQGHWVETRDCFLQQCPVDGKWQAWASWGS 533
Query: 981 CSSSCGIGVRIRSKWLKEKPYNGGRPCP-KLDLKNQAQVHEAVPCYSECNQYSWVVEHWS 1039
CS +CG G + R + + P+ GG C D Q + C++ ++ W
Sbjct: 534 CSVTCGAGSQRRER-VCSGPFFGGAACQGPQDEYRQCGTQRCPEPHEICDEDNFGAVIWK 592
Query: 1040 SCKINNELRSLRC 1052
E+ ++RC
Sbjct: 593 ETPA-GEVAAVRC 604
Score = 65.1 bits (157), Expect = 5e-10
Identities = 91/376 (24%), Positives = 134/376 (35%), Gaps = 103/376 (27%)
Query: 576 WTEWSSCSQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHRLCNDHSCMQLHWE 635
W+ W C++ C G QTR+RT L G G C L+E R CN +C
Sbjct: 267 WSLWGECTRDCGG----GLQTRTRTCLPAPGVEGGGC--EGVLEEGRQCNREAC------ 314
Query: 636 TSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPET 695
P G S + +L +T RR + +G + + P+T
Sbjct: 315 -GPAGRTSSRS--QSLRST-------------DARR----REELGDELQQF--GFPAPQT 352
Query: 696 VRPCFLPCKKDCIVTAFSEWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQECPDTLYEE 755
P +S W+ C C G Q+R R + + + +C L E+
Sbjct: 353 GDPA---------AEEWSPWSVCSSTCGEG----WQTRTRFCVSSSYS--TQCSGPLREQ 397
Query: 756 RECEDVSLCPVY----RWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCISDDN 811
R C + ++CPV+ W P WS C S CG+G + R +C
Sbjct: 398 RLCNNSAVCPVHGAWDEWSP--WSLC--------------SSTCGRGFRDRTRTCRPPQF 441
Query: 812 RSAEMMECLKQTNGMPLLVQECTVPCRE-DCTFTAWSKFTPCSTNC-EATKSRRRQLTGK 869
KQT + + P R D + WS ++ CS +C + + R R+ G
Sbjct: 442 GGNPCEGPEKQTKFCNIAL----CPGRAVDGNWNEWSSWSACSASCSQGRQQRTRECNGP 497
Query: 870 SRKKEKCQDSDLYPLVET-----ELCPCDEFISQPYGNWSDCILPEGRREPHRGLRVQAD 924
S +CQ VET + CP D Q + +W C
Sbjct: 498 SYGGAECQGH----WVETRDCFLQQCPVDG-KWQAWASWGSC------------------ 534
Query: 925 SKECGEGLRFRAVACS 940
S CG G + R CS
Sbjct: 535 SVTCGAGSQRRERVCS 550
Score = 63.9 bits (154), Expect = 1e-09
Identities = 72/291 (24%), Positives = 108/291 (37%), Gaps = 45/291 (15%)
Query: 901 GNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSDKNGRPVDPSFCSSSGYIQE 960
G + +L EGR Q + + CG R + ++ R D G +
Sbjct: 296 GGGCEGVLEEGR---------QCNREACGPAGR---TSSRSQSLRSTDARRREELGDELQ 343
Query: 961 KCVIPCPF--DCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQV 1018
+ P P D +WS W CSS+CG G + R+++ Y+ P L+ Q
Sbjct: 344 QFGFPAPQTGDPAAEEWSPWSVCSSTCGEGWQTRTRFCVSSSYSTQCSGP---LREQRLC 400
Query: 1019 HEAVPCYSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNL 1078
+ + C W WS C S CG G + R C G N
Sbjct: 401 NNSAVCPVHGAWDEW--SPWSLC-------SSTCGRGFRDRTRTCRPPQFG------GNP 445
Query: 1079 CNQDEIPPETQSCSL-MCPNECV---MSEWGLWSKCPQSCDPHTMQRRTRHLLRPSLNSR 1134
C E +T+ C++ +CP V +EW WS C SC Q+RTR PS
Sbjct: 446 CEGPE--KQTKFCNIALCPGRAVDGNWNEWSSWSACSASCS-QGRQQRTRECNGPSYGGA 502
Query: 1135 TC-AEDSQVQPCLLNENCFQFQYNL-TEWSTCQLSENAPCGQGVRTRLLSC 1183
C + + C L + ++ W +C ++ CG G + R C
Sbjct: 503 ECQGHWVETRDCFLQQCPVDGKWQAWASWGSCSVT----CGAGSQRRERVC 549
Score = 63.5 bits (153), Expect = 2e-09
Identities = 90/346 (26%), Positives = 113/346 (32%), Gaps = 102/346 (29%)
Query: 400 CGGGIQTREVYC--AQSVPAAAALRAKEVSRPVEKALCVGPAPLPSQLCNIPCSTDC--- 454
CGGG+QTR C A V E R + C GPA S STD
Sbjct: 277 CGGGLQTRTRTCLPAPGVEGGGCEGVLEEGRQCNREAC-GPAGRTSSRSQSLRSTDARRR 335
Query: 455 --------------------IVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPA 494
WS W +C C + G++TR R + S
Sbjct: 336 EELGDELQQFGFPAPQTGDPAAEEWSPWSVC-SSTCGE-----GWQTRTRFCVSSSY--- 386
Query: 495 GHCPHLVESVPCEDPMCYRWLASEGICFPDHGK-------------CGLGHRILKAVCQN 541
S C P+ + L + P HG CG G R C
Sbjct: 387 --------STQCSGPLREQRLCNNSAVCPVHGAWDEWSPWSLCSSTCGRGFRDRTRTC-- 436
Query: 542 DRGEDVSGSLCPVPPPPERKSCEI---PCR-MDCVLSEWTEWSSCSQSCSNKNSDGKQTR 597
R G+ C P + K C I P R +D +EW+ WS+CS SC S G+Q R
Sbjct: 437 -RPPQFGGNPCE-GPEKQTKFCNIALCPGRAVDGNWNEWSSWSACSASC----SQGRQQR 490
Query: 598 SRTILALAGEGGKPCPPSQALQEHRLCNDHSC-MQLHWET-SPWGPCSEDTLVTALNATI 655
+R GG C E R C C + W+ + WG CS
Sbjct: 491 TRECNG-PSYGGAECQGHWV--ETRDCFLQQCPVDGKWQAWASWGSCS------------ 535
Query: 656 GWNGEATCGVGIQTRRVFCVKSHVG------------QVMTKRCPD 689
TCG G Q R C G Q T+RCP+
Sbjct: 536 -----VTCGAGSQRRERVCSGPFFGGAACQGPQDEYRQCGTQRCPE 576
Score = 58.2 bits (139), Expect = 6e-08
Identities = 75/282 (26%), Positives = 97/282 (34%), Gaps = 58/282 (20%)
Query: 157 WSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPN-LTESRACDAPISCPLGEEEYTFSLKVG 215
W C++ CG LQ RTR + P G C L E R C+ P G
Sbjct: 270 WGECTRDCGGGLQTRTRTCLPAPGVEGGGCEGVLEEGRQCNREACGPAGR---------- 319
Query: 216 PWSKCRLPHLKEINPSGRTVLDFNSDSNERVTFK--HQSYKAHHHSKSWAI-----EIGY 268
+ R L+ + R L D ++ F A W++ G+
Sbjct: 320 --TSSRSQSLRSTDARRREEL---GDELQQFGFPAPQTGDPAAEEWSPWSVCSSTCGEGW 374
Query: 269 QTRQVSCTRSDGQNAMLSLCLQDSFPLTVQ-----SCIMPKDCETSQWSSWSPCSKTCRS 323
QTR C S S Q S PL Q S + P +WS WS CS TC
Sbjct: 375 QTRTRFCVSS-------SYSTQCSGPLREQRLCNNSAVCPVHGAWDEWSPWSLCSSTCGR 427
Query: 324 GSLLPGFRSRSRNVKHMAIGGGK-ECPELLEKEACIVEGELLQQCPRY----SWRT-SEW 377
GFR R+R + GG E PE K I CP +W S W
Sbjct: 428 -----GFRDRTRTCRPPQFGGNPCEGPEKQTKFCNIA------LCPGRAVDGNWNEWSSW 476
Query: 378 KECQVSLLLEQQDPHWHVTGPVCGGG------IQTREVYCAQ 413
C S +Q GP GG ++TR+ + Q
Sbjct: 477 SACSASCSQGRQQRTRECNGPSYGGAECQGHWVETRDCFLQQ 518
Score = 55.8 bits (133), Expect = 3e-07
Identities = 73/310 (23%), Positives = 104/310 (33%), Gaps = 81/310 (26%)
Query: 144 PCPR--DCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPN-LTESRACDAPIS 200
P P+ D E+ PWS CS CG+ Q RTR ++ QC L E R C+
Sbjct: 348 PAPQTGDPAAEEWSPWSVCSSTCGEGWQTRTRFCVSSSY--STQCSGPLREQRLCNNSAV 405
Query: 201 CPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDSNERVTFKHQSYKAHHHSK 260
CP+ +S PWS C + RT N
Sbjct: 406 CPVHGAWDEWS----PWSLCSSTCGRGFRDRTRTCRPPQFGGNP---------------- 445
Query: 261 SWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCETSQWSSWSPCSKT 320
C + Q ++ L + D ++WSSWS CS +
Sbjct: 446 --------------CEGPEKQTKFCNIALCPGRAV---------DGNWNEWSSWSACSAS 482
Query: 321 CRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEGELLQQCP-RYSWRT-SEWK 378
C G + R+R + GG + +E C LQQCP W+ + W
Sbjct: 483 CSQGR-----QQRTRECNGPSYGGAECQGHWVETRDC-----FLQQCPVDGKWQAWASWG 532
Query: 379 ECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRA-KEVSRPVEKALCVG 437
C V+ CG G Q RE C+ AA + ++ R C
Sbjct: 533 SCSVT----------------CGAGSQRRERVCSGPFFGGAACQGPQDEYRQCGTQRC-- 574
Query: 438 PAPLPSQLCN 447
P P ++C+
Sbjct: 575 --PEPHEICD 582
Score = 54.7 bits (130), Expect = 7e-07
Identities = 78/335 (23%), Positives = 110/335 (32%), Gaps = 79/335 (23%)
Query: 13 KLAGPWGRCTGDCGPGGVQSRAVWCFHV-------------DGWTSHLSNCGESNRPPKE 59
KL WG CT DCG GG+Q+R C +G + CG + R
Sbjct: 265 KLWSLWGECTRDCG-GGLQTRTRTCLPAPGVEGGGCEGVLEEGRQCNREACGPAGRTSSR 323
Query: 60 RSCFRVCDWHSDLFQWEVSDWHHCVLVPY------ARGEVKPRTAECVTAQHGLQHRMVR 113
R D + E+ D P A E P + T G Q R
Sbjct: 324 SQSLRSTDARR---REELGDELQQFGFPAPQTGDPAAEEWSPWSVCSSTCGEGWQTRTRF 380
Query: 114 CIQKLNRTVVANEICEHFALQPPTEQAC--LIPCPRDCVVSEFLPWSNCSKGCGKKLQHR 171
C+ T + + E ++ C CP E+ PWS CS CG+ + R
Sbjct: 381 CVSSSYSTQCSGPLRE--------QRLCNNSAVCPVHGAWDEWSPWSLCSSTCGRGFRDR 432
Query: 172 TRAVIAPPLFGGLQCPN-LTESRACDAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINP 230
TR PP FGG C +++ C+ + CP + ++ + WS C
Sbjct: 433 TR-TCRPPQFGGNPCEGPEKQTKFCNIAL-CPGRAVDGNWN-EWSSWSAC---------- 479
Query: 231 SGRTVLDFNSDSNERVTFKHQSYKAHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQ 290
S + G Q R C A
Sbjct: 480 ------------------------------SASCSQGRQQRTRECNGPSYGGAECQGHWV 509
Query: 291 DSFPLTVQSCIMPKDCETSQWSSWSPCSKTCRSGS 325
++ +Q C P D + W+SW CS TC +GS
Sbjct: 510 ETRDCFLQQC--PVDGKWQAWASWGSCSVTCGAGS 542
Score = 50.8 bits (120), Expect = 1e-05
Identities = 81/370 (21%), Positives = 117/370 (31%), Gaps = 79/370 (21%)
Query: 311 WSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLE------KEACIVEGELL 364
WS W C++ C G ++R+R G C +LE +EAC G
Sbjct: 267 WSLWGECTRDCGGG-----LQTRTRTCLPAPGVEGGGCEGVLEEGRQCNREACGPAGRTS 321
Query: 365 QQCPRYSWRTSEWKECQVSLLLEQ--------QDPH------WHVTGPVCGGGIQTREVY 410
+ + +E ++ L+Q DP W V CG G QTR +
Sbjct: 322 SRSQSLRSTDARRRE-ELGDELQQFGFPAPQTGDPAAEEWSPWSVCSSTCGEGWQTRTRF 380
Query: 411 CAQSVPAAAALRAKEVSRPVEKALCVGPAPLPSQLCN--IPCSTDCIVSSWSAWGLCIHE 468
C S + C GP +LCN C WS W LC
Sbjct: 381 CVSSSYSTQ---------------CSGPLR-EQRLCNNSAVCPVHGAWDEWSPWSLC-SS 423
Query: 469 NCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVESVPCEDPMCYRWLASEGICFPDHGKC 528
C +GFR R R G PCE P + +C P
Sbjct: 424 TCG-----RGFRDRTRTCRPPQFG----------GNPCEGPEKQTKFCNIALC-PGRAVD 467
Query: 529 GLGHR-----ILKAVCQNDR--------GEDVSGSLCPVPPPPERKSCEIPCRMDCVLSE 575
G + A C R G G+ C R C +D
Sbjct: 468 GNWNEWSSWSACSASCSQGRQQRTRECNGPSYGGAECQGHWVETRDCFLQQCPVDGKWQA 527
Query: 576 WTEWSSCSQSCSNKNSDGKQTRSRTILALAGEGG-----KPCPPSQALQEHRLCNDHSCM 630
W W SCS +C + ++ S A G + C + + H +C++ +
Sbjct: 528 WASWGSCSVTCGAGSQRRERVCSGPFFGGAACQGPQDEYRQCGTQRCPEPHEICDEDNFG 587
Query: 631 QLHWETSPWG 640
+ W+ +P G
Sbjct: 588 AVIWKETPAG 597
Score = 40.4 bits (93), Expect = 0.014
Identities = 65/269 (24%), Positives = 97/269 (36%), Gaps = 66/269 (24%)
Query: 305 DCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEGELL 364
D +WS WS CS TC G+++R+R ++ +C L ++ +
Sbjct: 354 DPAAEEWSPWSVCSSTCGE-----GWQTRTRFC--VSSSYSTQCSGPLREQRLCNNSAV- 405
Query: 365 QQCPRY-SWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRA 423
CP + +W EW W + CG G + R C
Sbjct: 406 --CPVHGAW--DEWSP-------------WSLCSSTCGRGFRDRTRTC------------ 436
Query: 424 KEVSRPVEKA--LCVGPAPLPSQLCNIPC----STDCIVSSWSAWGLCIHENCHDPQGKK 477
RP + C GP ++ CNI + D + WS+W C +C +
Sbjct: 437 ----RPPQFGGNPCEGPEK-QTKFCNIALCPGRAVDGNWNEWSSWSAC-SASC-----SQ 485
Query: 478 GFRTRQRHVLMESTGPAGHCPHLVESVPC---EDPMCYRW--LASEGICFPDHGKCGLGH 532
G + R R S G A H VE+ C + P+ +W AS G C CG G
Sbjct: 486 GRQQRTRECNGPSYGGAECQGHWVETRDCFLQQCPVDGKWQAWASWGSC---SVTCGAGS 542
Query: 533 RILKAVCQNDRGEDVSGSLCPVPPPPERK 561
+ + VC G G+ C P R+
Sbjct: 543 QRRERVCS---GPFFGGAACQGPQDEYRQ 568
>gi|40317626 thrombospondin 1 precursor [Homo sapiens]
Length = 1170
Score = 74.7 bits (182), Expect = 7e-13
Identities = 80/324 (24%), Positives = 126/324 (38%), Gaps = 78/324 (24%)
Query: 1024 CYSECNQY----SWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLC 1079
CY QY W V+ + C N + T +K+ C C
Sbjct: 318 CYHNGVQYRNNEEWTVDSCTECHCQNSV--------TICKKVSCPIMP-----------C 358
Query: 1080 NQDEIPPETQSCSLMCPNECV---MSEWGLWSKCPQSCDPHTMQRRTRHLLRPSLNSRTC 1136
+ +P + + C P++ S W W+ C SC + +Q+R R SLN+R
Sbjct: 359 SNATVP-DGECCPRCWPSDSADDGWSPWSEWTSCSTSCG-NGIQQRGRSC--DSLNNRCE 414
Query: 1137 AEDSQVQPCLLNENCFQFQYN-----LTEWSTCQLSENAPCGQGVRTRLLSCVCS----D 1187
Q + C + E +F+ + + WS+C ++ CG GV TR+ C +
Sbjct: 415 GSSVQTRTCHIQECDKRFKQDGGWSHWSPWSSCSVT----CGDGVITRIRLCNSPSPQMN 470
Query: 1188 GKPVSMDQCEQHNLEKPQRMSIPCLVECVVNCQLSGWTAWTECSQTCGHGGRMSRTRFII 1247
GKP + E +K C +N W+ W CS TCG GG R+R
Sbjct: 471 GKPCEGEARETKACKKDA---------CPINGGWGPWSPWDICSVTCG-GGVQKRSRLCN 520
Query: 1248 MPT-QGEGRPCPTELTQ-----EKTCPV-----TPCYSWVL------GNWSACKLEGGDC 1290
PT Q G+ C ++T+ ++ CP+ PC++ V G+W G
Sbjct: 521 NPTPQFGGKDCVGDVTENQICNKQDCPIDGCLSNPCFAGVKCTSYPDGSWKCGACPPGYS 580
Query: 1291 GEGVQIRSL--------SCMVHSG 1306
G G+Q + +C H+G
Sbjct: 581 GNGIQCTDVDECKEVPDACFNHNG 604
Score = 55.5 bits (132), Expect = 4e-07
Identities = 80/333 (24%), Positives = 113/333 (33%), Gaps = 78/333 (23%)
Query: 910 EGRREP---HRGLRVQADSK----ECGEGLRFRAVACSDKNGRPVDPSFCSSSGYIQEKC 962
E RR P H G++ + + + C E +V K P+ P CS++ +C
Sbjct: 311 ELRRPPLCYHNGVQYRNNEEWTVDSCTECHCQNSVTICKKVSCPIMP--CSNATVPDGEC 368
Query: 963 VIPC----PFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQV 1018
C D S WS W SCS+SCG G++ R GR C L+ + +
Sbjct: 369 CPRCWPSDSADDGWSPWSEWTSCSTSCGNGIQQR-----------GRSCDSLNNRCEGSS 417
Query: 1019 HEAVPCY-SECNQY-----SWV-VEHWSSCKINNELRSLRCGGGTQSRKIRC------VN 1065
+ C+ EC++ W WSSC S+ CG G +R C +N
Sbjct: 418 VQTRTCHIQECDKRFKQDGGWSHWSPWSSC-------SVTCGDGVITRIRLCNSPSPQMN 470
Query: 1066 TADGEGGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEWGLWSKCPQSCDPHTMQR-RTR 1124
EG A ++ C +D CP W W C +C +R R
Sbjct: 471 GKPCEGEARETKACKKD-----------ACPINGGWGPWSPWDICSVTCGGGVQKRSRLC 519
Query: 1125 HLLRPSLNSRTCA-----------EDSQVQPCLLNENCFQ----FQYNLTEWSTCQLSEN 1169
+ P + C +D + CL N CF Y W
Sbjct: 520 NNPTPQFGGKDCVGDVTENQICNKQDCPIDGCLSNP-CFAGVKCTSYPDGSWKC------ 572
Query: 1170 APCGQGVRTRLLSCVCSDGKPVSMDQCEQHNLE 1202
C G + C D D C HN E
Sbjct: 573 GACPPGYSGNGIQCTDVDECKEVPDACFNHNGE 605
Score = 55.1 bits (131), Expect = 5e-07
Identities = 70/269 (26%), Positives = 94/269 (34%), Gaps = 64/269 (23%)
Query: 574 SEWTEWSSCSQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHRLCNDHSCMQ-- 631
S W+EW+SCS SC N G Q R R+ +L C S + R C+ C +
Sbjct: 383 SPWSEWTSCSTSCGN----GIQQRGRSCDSL----NNRCEGSSV--QTRTCHIQECDKRF 432
Query: 632 ------LHWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTK 685
HW SPW CS TCG G+ TR C S Q+ K
Sbjct: 433 KQDGGWSHW--SPWSSCS-----------------VTCGDGVITRIRLC-NSPSPQMNGK 472
Query: 686 RCPDSTRPETVRPCFLPCKKD-CIVTA----FSEWTPCPRMCQAGNATVKQSRYRIIIQE 740
C R CKKD C + +S W C C G Q R R+
Sbjct: 473 PCEGEARETKA------CKKDACPINGGWGPWSPWDICSVTCGGG----VQKRSRLCNNP 522
Query: 741 AAN-GGQECPDTLYEERECEDVSLCPVYRWKPQ---KWSPCILVPESVWQGITGSSEACG 796
GG++C + E + C CP+ C P+ W+ AC
Sbjct: 523 TPQFGGKDCVGDVTENQICNKQD-CPIDGCLSNPCFAGVKCTSYPDGSWK-----CGACP 576
Query: 797 KGLQTRAVSCISDDNRSAEMMECLKQTNG 825
G + C +D + E+ + NG
Sbjct: 577 PGYSGNGIQC-TDVDECKEVPDACFNHNG 604
Score = 54.3 bits (129), Expect = 9e-07
Identities = 55/210 (26%), Positives = 77/210 (36%), Gaps = 45/210 (21%)
Query: 813 SAEMMECLKQTNGMPLLVQECTVPCREDCTFTAWSKFTPCSTNC-EATKSRRRQLTGKSR 871
S +M C T C D ++ WS++T CST+C + R R +
Sbjct: 352 SCPIMPCSNATVPDGECCPRCWPSDSADDGWSPWSEWTSCSTSCGNGIQQRGRSCDSLN- 410
Query: 872 KKEKCQDSDLYPLVETELC---PCDEFISQPYG-----NWSDCILPEGRREPHRGLRVQA 923
+C+ S V+T C CD+ Q G WS C
Sbjct: 411 --NRCEGSS----VQTRTCHIQECDKRFKQDGGWSHWSPWSSC----------------- 447
Query: 924 DSKECGEGLRFRAVACS----DKNGRPVDPSFCSSSGYIQEKC-VIPCPFDCKLSDWSSW 978
S CG+G+ R C+ NG+P C + C CP + WS W
Sbjct: 448 -SVTCGDGVITRIRLCNSPSPQMNGKP-----CEGEARETKACKKDACPINGGWGPWSPW 501
Query: 979 GSCSSSCGIGVRIRSKWLKE-KPYNGGRPC 1007
CS +CG GV+ RS+ P GG+ C
Sbjct: 502 DICSVTCGGGVQKRSRLCNNPTPQFGGKDC 531
Score = 47.8 bits (112), Expect = 9e-05
Identities = 55/214 (25%), Positives = 74/214 (34%), Gaps = 53/214 (24%)
Query: 1222 SGWTAWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPT-------ELTQEKTCPVTPC-- 1272
S W+ WT CS +CG+G Q GR C + Q +TC + C
Sbjct: 383 SPWSEWTSCSTSCGNG------------IQQRGRSCDSLNNRCEGSSVQTRTCHIQECDK 430
Query: 1273 -----YSWV-LGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQ 1326
W WS+C + CG+GV R C S ++ G+ + E
Sbjct: 431 RFKQDGGWSHWSPWSSCSV---TCGDGVITRIRLCNSPSPQMN---GKPCEGEARE---- 480
Query: 1327 DSILKQLCSVPCPGDCHLTEWSEWSTCELTCIDG-----RSFETVGRQSRSRTFIIQSFE 1381
K CP + WS W C +TC G R Q + + E
Sbjct: 481 ---TKACKKDACPINGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTE 537
Query: 1382 NQ----DSCPQQVLETRPCTGG-KCYHY---TWK 1407
NQ CP + PC G KC Y +WK
Sbjct: 538 NQICNKQDCPIDGCLSNPCFAGVKCTSYPDGSWK 571
Score = 44.3 bits (103), Expect = 0.001
Identities = 55/234 (23%), Positives = 82/234 (35%), Gaps = 65/234 (27%)
Query: 774 WSPCILVPESVWQGITGSSEACGKGLQTRAVSCISDDNR----SAEMMECLKQTNGMPLL 829
WSP W T S +CG G+Q R SC S +NR S + C
Sbjct: 382 WSP--------WSEWTSCSTSCGNGIQQRGRSCDSLNNRCEGSSVQTRTC---------H 424
Query: 830 VQECTVPCREDCTFTAWSKFTPCSTNC--------EATKSRRRQLTGKSRKKEKCQDSDL 881
+QEC ++D ++ WS ++ CS C S Q+ GK + E +
Sbjct: 425 IQECDKRFKQDGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETK-- 482
Query: 882 YPLVETELCPCDEFISQPYGNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSD 941
+ + CP + P+ W C S CG G++ R+ C++
Sbjct: 483 --ACKKDACPINGGWG-PWSPWDIC------------------SVTCGGGVQKRSRLCNN 521
Query: 942 KNGRPVDPSFCSSS--GYIQEKCVIPCPFDCKLSDWSSWGSCSSSCGIGVRIRS 993
P F G + E + C D G S+ C GV+ S
Sbjct: 522 PT-----PQFGGKDCVGDVTENQI------CNKQDCPIDGCLSNPCFAGVKCTS 564
Score = 43.5 bits (101), Expect = 0.002
Identities = 35/117 (29%), Positives = 48/117 (41%), Gaps = 26/117 (22%)
Query: 561 KSCEIPCRMDCVLSEWTEWSSCSQSCSNKNSDGKQTRSRTILALAGE-GGKPCPPSQALQ 619
+ C+ + D S W+ WSSCS +C DG TR R + + + GKPC +
Sbjct: 426 QECDKRFKQDGGWSHWSPWSSCSVTC----GDGVITRIRLCNSPSPQMNGKPC--EGEAR 479
Query: 620 EHRLCNDHSC-MQLHW-ETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFC 674
E + C +C + W SPW CS TCG G+Q R C
Sbjct: 480 ETKACKKDACPINGGWGPWSPWDICS-----------------VTCGGGVQKRSRLC 519
Score = 40.0 bits (92), Expect = 0.018
Identities = 44/158 (27%), Positives = 54/158 (34%), Gaps = 39/158 (24%)
Query: 267 GYQTRQVSC----TRSDGQNAMLSLCLQDSFPLTVQSCI--MPKDCETSQWSSWSPCSKT 320
G Q R SC R +G + C +Q C +D S WS WS CS T
Sbjct: 398 GIQQRGRSCDSLNNRCEGSSVQTRTC-------HIQECDKRFKQDGGWSHWSPWSSCSVT 450
Query: 321 CRSGSLLPGFRSRSRNVKHMAIGGGKECP-ELLEKEACIVEGELLQQCP-RYSWRTSEWK 378
C G + R R N + GK C E E +AC + CP W W
Sbjct: 451 CGDGVIT---RIRLCNSPSPQM-NGKPCEGEARETKACKKDA-----CPINGGW--GPWS 499
Query: 379 ECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVP 416
W + CGGG+Q R C P
Sbjct: 500 P-------------WDICSVTCGGGVQKRSRLCNNPTP 524
Score = 38.1 bits (87), Expect = 0.068
Identities = 46/188 (24%), Positives = 68/188 (36%), Gaps = 29/188 (15%)
Query: 18 WGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFRVCDWHSDLFQWEV 77
W C+ CG G+Q R C D + R + C + W
Sbjct: 388 WTSCSTSCG-NGIQQRGRSC---DSLNNRCEGSSVQTRTCHIQECDKRFKQDGGWSHW-- 441
Query: 78 SDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHFALQPPT 137
S W C VT G+ R+ C + + + CE A + T
Sbjct: 442 SPWSSC----------------SVTCGDGVITRIRLCNSPSPQ--MNGKPCEGEARE--T 481
Query: 138 EQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAP-PLFGGLQC-PNLTESRAC 195
+ CP + + PW CS CG +Q R+R P P FGG C ++TE++ C
Sbjct: 482 KACKKDACPINGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQIC 541
Query: 196 DAPISCPL 203
+ CP+
Sbjct: 542 NKQ-DCPI 548
Score = 35.8 bits (81), Expect = 0.34
Identities = 36/118 (30%), Positives = 49/118 (41%), Gaps = 19/118 (16%)
Query: 105 HGLQHRMVRCIQKLNRTVVANEICEHFALQPPT--EQACLIPCPRDCVVSEFLPWSNCSK 162
+G+Q R C NR CE ++Q T Q C +D S + PWS+CS
Sbjct: 397 NGIQQRGRSCDSLNNR-------CEGSSVQTRTCHIQECDKRFKQDGGWSHWSPWSSCSV 449
Query: 163 GCGKKLQHRTRAVIAP-PLFGGLQCP-NLTESRACDAPISCPLGEEEYTFSLKVGPWS 218
CG + R R +P P G C E++AC +CP+ GPWS
Sbjct: 450 TCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKD-ACPING-------GWGPWS 499
Score = 34.3 bits (77), Expect = 0.98
Identities = 58/259 (22%), Positives = 83/259 (32%), Gaps = 68/259 (26%)
Query: 233 RTVLDFNSDSNERVTFKHQSYKAHHHSKSWAIEIGYQTRQV------SCTRSDGQNAMLS 286
RT++ DS +VT +++ G Q R SCT QN++ +
Sbjct: 288 RTIVTTLQDSIRKVTEENKELANELRRPPLCYHNGVQYRNNEEWTVDSCTECHCQNSV-T 346
Query: 287 LCLQDSFPLTVQSCIMPKDCET--------------SQWSSWSPCSKTCRSGSLLPGFRS 332
+C + S P+ S D E S WS W+ CS +C + G +
Sbjct: 347 ICKKVSCPIMPCSNATVPDGECCPRCWPSDSADDGWSPWSEWTSCSTSCGN-----GIQQ 401
Query: 333 RSRNVKHMAIGGGKECPELLEKEACIVEGELLQQCPRYSWRTSEWKECQVSLLLEQQDPH 392
R G+ C L + EG +Q RT +EC +QD
Sbjct: 402 R-----------GRSCDSLNNR----CEGSSVQT------RTCHIQECDKRF---KQDGG 437
Query: 393 WHVTGP------VCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKALCVGPAPLPSQLC 446
W P CG G+ TR C P + C G A
Sbjct: 438 WSHWSPWSSCSVTCGDGVITRIRLCNSPSP------------QMNGKPCEGEARETKACK 485
Query: 447 NIPCSTDCIVSSWSAWGLC 465
C + WS W +C
Sbjct: 486 KDACPINGGWGPWSPWDIC 504
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 73.6 bits (179), Expect = 1e-12
Identities = 66/223 (29%), Positives = 95/223 (42%), Gaps = 29/223 (13%)
Query: 1031 YSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCN-QDEIPPETQ 1089
YSW W+ C S +C GG+Q + + C N D AV + C+ ++P +
Sbjct: 827 YSWHYAPWTKC-------SAQCAGGSQVQAVECRNQLDSS--AVAPHYCSAHSKLPKRQR 877
Query: 1090 SCSLM-CPNECVMSEWGLWSKCPQSCDPHTMQRRTRHLLRPSLNSRTCAEDS---QVQPC 1145
+C+ CP + V+ G WS C +SCD R R S +DS Q +P
Sbjct: 878 ACNTEPCPPDWVV---GNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPP 934
Query: 1146 LLNENCFQFQYNLTEWSTCQLSENAP-CGQGVRTRLLSCVCSDGKPVSMDQCEQHNLEKP 1204
+L E C EW+ SE P CG G+R R++ C +D + ++ KP
Sbjct: 935 VL-EAC-HGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHR-ATLPPAHCSPAAKP 991
Query: 1205 QRMSIPCLVEC-VVNCQLSGWTA--WTECSQTCGHGGRMSRTR 1244
P + C + C + W A W ECS CG G R R
Sbjct: 992 -----PATMRCNLRRCPPARWVAGEWGECSAQCGVGQRQRSVR 1029
Score = 68.6 bits (166), Expect = 5e-11
Identities = 73/278 (26%), Positives = 97/278 (34%), Gaps = 63/278 (22%)
Query: 846 WSKFTPCSTNCEATKSR-----RRQLTGKSRKKEKCQDSDLYP----LVETELCPCDEFI 896
++ +T CS C R QL + C P TE CP D +
Sbjct: 831 YAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVV 890
Query: 897 SQPYGNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVAC----SDKNGRPVDPSFC 952
GNWS C S+ C G+R R+V C S + +D S C
Sbjct: 891 ----GNWSLC------------------SRSCDAGVRSRSVVCQRRVSAAEEKALDDSAC 928
Query: 953 SSSGY-IQEKCVIP-CPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKL 1010
+ E C P CP + DWS C+ SCG G+R R K + P
Sbjct: 929 PQPRPPVLEACHGPTCPPEWAALDWSE---CTPSCGPGLRHRVVLCKSADHRA--TLPPA 983
Query: 1011 DLKNQAQVHEAVPC-YSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADG 1069
A+ + C C WV W C S +CG G + R +RC + G
Sbjct: 984 HCSPAAKPPATMRCNLRRCPPARWVAGEWGEC-------SAQCGVGQRQRSVRCTSHT-G 1035
Query: 1070 EGGAVDSNLCNQDEIPPETQSCSLMC--------PNEC 1099
+ S+ C + PP TQ C C P EC
Sbjct: 1036 QA----SHECTEALRPPTTQQCEAKCDSPTPGDGPEEC 1069
Score = 68.2 bits (165), Expect = 6e-11
Identities = 53/187 (28%), Positives = 69/187 (36%), Gaps = 40/187 (21%)
Query: 528 CGLGHRILKAVCQND----RGEDVSGSLCPVPPPPERKSCEIPCRMDCVLSEWT--EWSS 581
C G R VCQ + + S CP P PP ++C P EW +WS
Sbjct: 900 CDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPT----CPPEWAALDWSE 955
Query: 582 CSQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHR-----LCNDHSCMQLHWET 636
C+ SC G R R +L + + PP+ + CN C W
Sbjct: 956 CTPSC------GPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPPARWVA 1009
Query: 637 SPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPETV 696
WG CS A CGVG + R V C SH GQ + C ++ RP T
Sbjct: 1010 GEWGECS-----------------AQCGVGQRQRSVRCT-SHTGQA-SHECTEALRPPTT 1050
Query: 697 RPCFLPC 703
+ C C
Sbjct: 1051 QQCEAKC 1057
Score = 65.5 bits (158), Expect = 4e-10
Identities = 63/227 (27%), Positives = 89/227 (39%), Gaps = 34/227 (14%)
Query: 925 SKECGEGLRFRAVACSDK-NGRPVDPSFCSSSGYI---QEKC-VIPCPFDCKLSDWSSWG 979
S +C G + +AV C ++ + V P +CS+ + Q C PCP D + +WS
Sbjct: 838 SAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSL-- 895
Query: 980 SCSSSCGIGVRIRSKWLK------EKPYNGGRPCPKLDLKNQAQVHEAVPCYSECNQYSW 1033
CS SC GVR RS + E+ CP+ + V EA C+ W
Sbjct: 896 -CSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQ----PRPPVLEA--CHGPTCPPEW 948
Query: 1034 VVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQSCSL 1093
WS C + CG G + R + C +AD ++ C+ PP T C+L
Sbjct: 949 AALDWSECTPS-------CGPGLRHRVVLC-KSADHRATLPPAH-CSPAAKPPATMRCNL 999
Query: 1094 MCPNECVMSEW--GLWSKCPQSCDPHTMQRRTRHLLRPSLNSRTCAE 1138
C + W G W +C C QR R S C E
Sbjct: 1000 ---RRCPPARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTE 1043
Score = 62.0 bits (149), Expect = 4e-09
Identities = 61/240 (25%), Positives = 87/240 (36%), Gaps = 48/240 (20%)
Query: 765 PVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCISDDNRSAEMMECLKQTN 824
P Y W W+ C S C G Q +AV C + + SA +
Sbjct: 825 PPYSWHYAPWTKC--------------SAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHS 870
Query: 825 GMPLLVQEC-TVPCREDCTFTAWSKFTPCSTNCEATKSRRRQLTGK--SRKKEKCQDSDL 881
+P + C T PC D WS CS +C+A R + + S +EK D
Sbjct: 871 KLPKRQRACNTEPCPPDWVVGNWSL---CSRSCDAGVRSRSVVCQRRVSAAEEKALDDSA 927
Query: 882 YPLVETELCPCDEFISQPYG----NWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAV 937
P + + P +WS+C + CG GLR R V
Sbjct: 928 CPQPRPPVLEACHGPTCPPEWAALDWSEC------------------TPSCGPGLRHRVV 969
Query: 938 ACSDKNGRP-VDPSFCSSSGYIQEKCVIPCPFD-CKLSDW--SSWGSCSSSCGIGVRIRS 993
C + R + P+ CS + + + C C + W WG CS+ CG+G R RS
Sbjct: 970 LCKSADHRATLPPAHCSPAA--KPPATMRCNLRRCPPARWVAGEWGECSAQCGVGQRQRS 1027
Score = 60.1 bits (144), Expect = 2e-08
Identities = 58/252 (23%), Positives = 92/252 (36%), Gaps = 46/252 (18%)
Query: 1224 WTAWTECSQTCGHGGRMSRTRFIIMPTQGEGRP--CPTELT---QEKTCPVTPCY-SWVL 1277
+ WT+CS C G ++ P C +++ C PC WV+
Sbjct: 831 YAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVV 890
Query: 1278 GNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSILKQLCSVP 1337
GNWS C C GV+ RS+ C + A ++D+ C + + +L+
Sbjct: 891 GNWSLC---SRSCDAGVRSRSVVCQRRVSAAEEKA--LDDSACPQP--RPPVLEACHGPT 943
Query: 1338 CPGDCHLTEWS--EWSTCELTCIDGRSFETVGRQSRSRTFIIQSFENQDSCP-------Q 1388
CP EW+ +WS C +C G R R + +S +++ + P
Sbjct: 944 CP-----PEWAALDWSECTPSC---------GPGLRHRVVLCKSADHRATLPPAHCSPAA 989
Query: 1389 QVLETRPCTGGKCYHYTWKASLW---------NNNERTVWCQRSDGVNVTGGCSPQARPA 1439
+ T C +C W A W +R+V C G + C+ RP
Sbjct: 990 KPPATMRCNLRRCPPARWVAGEWGECSAQCGVGQRQRSVRCTSHTG-QASHECTEALRPP 1048
Query: 1440 AIRQCIPACRKP 1451
+QC C P
Sbjct: 1049 TTQQCEAKCDSP 1060
Score = 56.2 bits (134), Expect = 2e-07
Identities = 61/254 (24%), Positives = 84/254 (33%), Gaps = 46/254 (18%)
Query: 368 PRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVS 427
P YSW + W +C C GG Q + V C + ++A
Sbjct: 825 PPYSWHYAPWTKCSAQ----------------CAGGSQVQAVECRNQLDSSA-------- 860
Query: 428 RPVEKALCVGPAPLP--SQLCNI-PCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQR 484
V C + LP + CN PC D +V +WS LC + + R+
Sbjct: 861 --VAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWS---LCSRSCDAGVRSRSVVCQRRV 915
Query: 485 HVLMESTGPAGHCPHLVESV--PCEDPMC-YRWLASE-GICFPDHGKCGLGHRILKAVCQ 540
E CP V C P C W A + C P G GL HR++
Sbjct: 916 SAAEEKALDDSACPQPRPPVLEACHGPTCPPEWAALDWSECTPSCGP-GLRHRVVLCKSA 974
Query: 541 NDRGEDVSGSLCPVPPPPERKSCEIPCRMDCVLSEWT--EWSSCSQSCSNKNSDGKQTRS 598
+ R P PP C + C + W EW CS C G++ RS
Sbjct: 975 DHRATLPPAHCSPAAKPPATMRCNL---RRCPPARWVAGEWGECSAQC----GVGQRQRS 1027
Query: 599 RTILALAGEGGKPC 612
+ G+ C
Sbjct: 1028 VRCTSHTGQASHEC 1041
Score = 54.7 bits (130), Expect = 7e-07
Identities = 59/272 (21%), Positives = 90/272 (33%), Gaps = 55/272 (20%)
Query: 576 WTEWSSCSQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQAL-QEHRLCNDHSCMQLHW 634
+ W+ CS C+ S + R L + C L + R CN C W
Sbjct: 831 YAPWTKCSAQCAG-GSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPP-DW 888
Query: 635 ETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPE 694
W CS +C G+++R V C + V K DS P+
Sbjct: 889 VVGNWSLCSR-----------------SCDAGVRSRSVVCQR-RVSAAEEKALDDSACPQ 930
Query: 695 TVRPCFLPCKKDCIVTAFS--EWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQECPDTL 752
P C ++ +W+ C C G R+R+++ ++A+ P
Sbjct: 931 PRPPVLEACHGPTCPPEWAALDWSECTPSCGPG------LRHRVVLCKSADHRATLPPAH 984
Query: 753 YEERECEDVSL------CPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSC 806
++ CP RW +W C S CG G + R+V C
Sbjct: 985 CSPAAKPPATMRCNLRRCPPARWVAGEWGEC--------------SAQCGVGQRQRSVRC 1030
Query: 807 ISDDNR-SAEMMECLKQTNGMPLLVQECTVPC 837
S + S E E L+ P Q+C C
Sbjct: 1031 TSHTGQASHECTEALR-----PPTTQQCEAKC 1057
Score = 50.4 bits (119), Expect = 1e-05
Identities = 66/273 (24%), Positives = 95/273 (34%), Gaps = 62/273 (22%)
Query: 311 WSSWSPCSKTCRSGSLLPGFRSR----SRNVKHMAIGGGKECPELLEKEACIVEGELLQQ 366
++ W+ CS C GS + R S V + P+ + AC E
Sbjct: 831 YAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPK--RQRACNTE-----P 883
Query: 367 CPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEV 426
CP W W C S C G+++R V C + V AA
Sbjct: 884 CPP-DWVVGNWSLCSRS----------------CDAGVRSRSVVCQRRVSAAE------- 919
Query: 427 SRPVEKALCVGPAPLPSQLCNIP-CSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRH 485
+ ++ + C P P + C+ P C + WS +C G R R
Sbjct: 920 EKALDDSACPQPRPPVLEACHGPTCPPEWAALDWSE----CTPSC-------GPGLRHRV 968
Query: 486 VLMES-----TGPAGHCPHLVE---SVPCEDPMC--YRWLASE-GICFPDHGKCGLGHRI 534
VL +S T P HC + ++ C C RW+A E G C +CG+G R
Sbjct: 969 VLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPPARWVAGEWGEC---SAQCGVGQRQ 1025
Query: 535 LKAVCQNDRGEDVSGSLCPVPPPPERKSCEIPC 567
C + G+ S PP + CE C
Sbjct: 1026 RSVRCTSHTGQ-ASHECTEALRPPTTQQCEAKC 1057
Score = 47.4 bits (111), Expect = 1e-04
Identities = 42/160 (26%), Positives = 66/160 (41%), Gaps = 30/160 (18%)
Query: 17 PWGRCTGDCGPGGVQSRAVWCFH-VDGWTSHLSNCGESNRPPKERSCFRVCDWHSDLFQW 75
PW +C+ C GG Q +AV C + +D C ++ PK + R C+ W
Sbjct: 833 PWTKCSAQCA-GGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQ---RACNTEPCPPDW 888
Query: 76 EVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRT---VVANEICEHFA 132
V +W C + C G++ R V C ++++ + + C
Sbjct: 889 VVGNWSLC-------------SRSC---DAGVRSRSVVCQRRVSAAEEKALDDSACPQ-- 930
Query: 133 LQPPTEQACLIP-CPRDCVVSEFLPWSNCSKGCGKKLQHR 171
+PP +AC P CP + L WS C+ CG L+HR
Sbjct: 931 PRPPVLEACHGPTCPPEWAA---LDWSECTPSCGPGLRHR 967
Score = 46.2 bits (108), Expect = 2e-04
Identities = 53/218 (24%), Positives = 79/218 (36%), Gaps = 30/218 (13%)
Query: 1271 PCYSWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSIL 1330
P YSW W+ C + C G Q++++ C S V C
Sbjct: 825 PPYSWHYAPWTKCSAQ---CAGGSQVQAVECRNQLDS-----SAVAPHYCSAHSKLPKRQ 876
Query: 1331 KQLCSVPCPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQSFENQDSCPQ-- 1388
+ + PCP D + WS C +C G +V Q R ++ ++ +CPQ
Sbjct: 877 RACNTEPCPPDWVV---GNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDD-SACPQPR 932
Query: 1389 -QVLETRPCTGGKCYHYTWKASLWNN---------NERTVWCQRSD--GVNVTGGCSPQA 1436
VLE C G C W A W+ R V C+ +D CSP A
Sbjct: 933 PPVLEA--CHGPTC-PPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAA 989
Query: 1437 RPAAIRQC-IPACRKPFSYCTQGGVCGCEKGYTEIMKS 1473
+P A +C + C + G C + G + +S
Sbjct: 990 KPPATMRCNLRRCPPARWVAGEWGECSAQCGVGQRQRS 1027
Score = 46.2 bits (108), Expect = 2e-04
Identities = 39/130 (30%), Positives = 53/130 (40%), Gaps = 27/130 (20%)
Query: 18 WGRCTGDCGPGGVQSRAVWCFHVDGW-TSHLSNCGESNRPPKERSC-FRVCDWHSDLFQW 75
W CT CGPG ++ R V C D T ++C + +PP C R C +W
Sbjct: 953 WSECTPSCGPG-LRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCP----PARW 1007
Query: 76 EVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHFALQP 135
+W C +A+C Q + R VRC + T A+ C AL+P
Sbjct: 1008 VAGEWGEC-------------SAQCGVGQ---RQRSVRCT---SHTGQASHECTE-ALRP 1047
Query: 136 PTEQACLIPC 145
PT Q C C
Sbjct: 1048 PTTQQCEAKC 1057
Score = 43.9 bits (102), Expect = 0.001
Identities = 23/54 (42%), Positives = 28/54 (51%), Gaps = 3/54 (5%)
Query: 14 LAGPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFRVCD 67
+AG WG C+ CG G Q R+V C G SH C E+ RPP + C CD
Sbjct: 1008 VAGEWGECSAQCGVGQRQ-RSVRCTSHTGQASH--ECTEALRPPTTQQCEAKCD 1058
Score = 42.0 bits (97), Expect = 0.005
Identities = 40/159 (25%), Positives = 56/159 (35%), Gaps = 20/159 (12%)
Query: 14 LAGPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFRVCDWHSDLF 73
+ G W C+ C GV+SR+V C + +S P C +
Sbjct: 889 VVGNWSLCSRSCD-AGVRSRSVVCQRRVSAAEEKA-LDDSACPQPRPPVLEACHGPTCPP 946
Query: 74 QWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHFAL 133
+W DW C T C GL+HR+V C +R + C A
Sbjct: 947 EWAALDWSEC-------------TPSCGP---GLRHRVVLCKSADHRATLPPAHCSPAAK 990
Query: 134 QPPTEQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRT 172
P T + L CP V+ W CS CG + R+
Sbjct: 991 PPATMRCNLRRCPPARWVAG--EWGECSAQCGVGQRQRS 1027
Score = 34.7 bits (78), Expect = 0.75
Identities = 20/51 (39%), Positives = 27/51 (52%), Gaps = 4/51 (7%)
Query: 1224 WTAWTECSQTCGHGGRMSRTRFI--IMPTQGEGRPCPTELTQEKTCPVTPC 1272
WT W +CS+TCG GG S +R PT G G+ C E + ++C C
Sbjct: 553 WTPWGDCSRTCG-GGVSSSSRHCDSPRPTIG-GKYCLGERRRHRSCNTDDC 601
Score = 33.1 bits (74), Expect = 2.2
Identities = 26/100 (26%), Positives = 40/100 (40%), Gaps = 17/100 (17%)
Query: 925 SKECGEGLRFRAVACSDKNGRPVDPSFCSSSGYIQEKCVIP---------CPF------- 968
S++C G + C K+ R + S ++ G + + I PF
Sbjct: 487 SRQCKYGEVCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPEGV 546
Query: 969 DCKLSDWSSWGSCSSSCGIGVRIRSKWL-KEKPYNGGRPC 1007
D W+ WG CS +CG GV S+ +P GG+ C
Sbjct: 547 DGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYC 586
Score = 32.7 bits (73), Expect = 2.8
Identities = 17/55 (30%), Positives = 27/55 (49%), Gaps = 3/55 (5%)
Query: 156 PWSNCSKGCGKKLQHRTRAVIAP-PLFGGLQC-PNLTESRACDAPISCPLGEEEY 208
PW +CS+ CG + +R +P P GG C R+C+ CP G +++
Sbjct: 555 PWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTD-DCPPGSQDF 608
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif, 7
preproprotein [Homo sapiens]
Length = 1686
Score = 73.2 bits (178), Expect = 2e-12
Identities = 74/250 (29%), Positives = 97/250 (38%), Gaps = 50/250 (20%)
Query: 846 WSKFTPCSTNCEATKSRRRQLTGKSRKKEKCQDSDLYPLVETELCPCDEFISQPYGNWSD 905
WS+ CST C R R ++ P L PC + S GNWS
Sbjct: 1420 WSE---CSTTCGLGAVWRPVRCSSGRDEDCAPAGRPQPARRCHLRPCATWHS---GNWSK 1473
Query: 906 CILPEGRREPHRGLRVQADSKECGEGLRFRAVACSD-KNGRPVDPSFCSSSGYIQEKCVI 964
C S+ CG G R V C D ++ RP+ P C G +
Sbjct: 1474 C------------------SRSCGGGSSVRDVQCVDTRDLRPLRPFHCQP-GPAKPPAHR 1514
Query: 965 PCPFDCKLSDW-SSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQA-QVHEAV 1022
PC LS + SSW CS +CG G + R CP+ L +A + +
Sbjct: 1515 PCGAQPCLSWYTSSWRECSEACGGGEQQRLV-----------TCPEPGLCEEALRPNTTR 1563
Query: 1023 PCYSE-CNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQ 1081
PC + C Q WVV W C S CGGG Q R ++CVNT G DS+ C
Sbjct: 1564 PCNTHPCTQ--WVVGPWGQC-------SGPCGGGVQRRLVKCVNTQTGL-PEEDSDQCGH 1613
Query: 1082 DEIPPETQSC 1091
+ P ++ C
Sbjct: 1614 EAWPESSRPC 1623
Score = 65.5 bits (158), Expect = 4e-10
Identities = 66/250 (26%), Positives = 92/250 (36%), Gaps = 60/250 (24%)
Query: 16 GPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFRVCDWHSDLFQW 75
GPW +CT CG GVQ + V+C +C RP ++ R C +W
Sbjct: 828 GPWTKCTVTCG-RGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQ---RKCSEQPCPARW 883
Query: 76 EVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKL---NRTVVANEICEHFA 132
+W C ++ C GL R V CI+ + ++ + CEH
Sbjct: 884 WAGEWQLC-------------SSSC--GPGGLSRRAVLCIRSVGLDEQSALEPPACEHLP 928
Query: 133 LQPPTEQAC--LIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPNLT 190
+PPTE C +PCP V WS CS CG+ Q R + C N
Sbjct: 929 -RPPTETPCNRHVPCPATWAVGN---WSQCSVTCGEGTQRR-----------NVLCTN-- 971
Query: 191 ESRACDAPISCPLGEE---EYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDSNERVT 247
D + C ++ E T SL + CR P L + P G S S+
Sbjct: 972 -----DTGVPCDEAQQPASEVTCSLPL-----CRWP-LGTLGPEGS-----GSGSSSHEL 1015
Query: 248 FKHQSYKAHH 257
F + HH
Sbjct: 1016 FNEADFIPHH 1025
Score = 63.2 bits (152), Expect = 2e-09
Identities = 47/168 (27%), Positives = 68/168 (40%), Gaps = 31/168 (18%)
Query: 1154 FQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHNLEKPQRMSIPCLV 1213
F ++ W+ C ++ CG+GV+ + + C+ PV + C+ L +P C
Sbjct: 823 FSWHYGPWTKCTVT----CGRGVQRQNVYCLERQAGPVDEEHCDP--LGRPDDQQRKCSE 876
Query: 1214 ECVVNCQLSGWTA-WTECSQTCGHGGRMSRTRFIIM-----------PTQGEGRPCP--- 1258
+ C W W CS +CG GG R I P E P P
Sbjct: 877 Q---PCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTE 933
Query: 1259 TELTQEKTCPVTPCYSWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSG 1306
T + CP T W +GNWS C + CGEG Q R++ C +G
Sbjct: 934 TPCNRHVPCPAT----WAVGNWSQCSV---TCGEGTQRRNVLCTNDTG 974
Score = 63.2 bits (152), Expect = 2e-09
Identities = 59/209 (28%), Positives = 82/209 (39%), Gaps = 59/209 (28%)
Query: 900 YGNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSDKNGRPVDPSFCSSSGY-- 957
YG W+ C + CG G++ + V C ++ PVD C G
Sbjct: 827 YGPWTKCTVT------------------CGRGVQRQNVYCLERQAGPVDEEHCDPLGRPD 868
Query: 958 -IQEKC-VIPCPFDCKLSDW--SSWGSCSSSCGIG-------VRIRSKWLKEKPYNGGRP 1006
Q KC PCP + W W CSSSCG G + IRS L E+
Sbjct: 869 DQQRKCSEQPCP-----ARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPA 923
Query: 1007 CPKLDL-KNQAQVHEAVPCYSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVN 1065
C L + + VPC + +W V +WS C S+ CG GTQ R + C N
Sbjct: 924 CEHLPRPPTETPCNRHVPCPA-----TWAVGNWSQC-------SVTCGEGTQRRNVLCTN 971
Query: 1066 TADGEGGAVDSNL-CNQDEIPPETQSCSL 1093
D+ + C++ + P +CSL
Sbjct: 972 ---------DTGVPCDEAQQPASEVTCSL 991
Score = 60.8 bits (146), Expect = 1e-08
Identities = 71/274 (25%), Positives = 96/274 (35%), Gaps = 83/274 (30%)
Query: 977 SWGSCSSSCGIGVRIR----SKWLKEKPYNGGRPCPKLDLKNQAQVHEAVPCYSECNQYS 1032
+W CS++CG+G R S E GRP P A+ PC +
Sbjct: 1419 NWSECSTTCGLGAVWRPVRCSSGRDEDCAPAGRPQP-------ARRCHLRPC------AT 1465
Query: 1033 WVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEI-PPETQSC 1091
W +WS C S CGGG+ R ++CV+T D + C PP + C
Sbjct: 1466 WHSGNWSKC-------SRSCGGGSSVRDVQCVDTRDLR--PLRPFHCQPGPAKPPAHRPC 1516
Query: 1092 SLMCPNECVMSEWGLWSKCPQSCDPHTMQRRT--------RHLLRPSLNSRTCAEDSQVQ 1143
C+ W +C ++C QR LRP+ +R C
Sbjct: 1517 G---AQPCLSWYTSSWRECSEACGGGEQQRLVTCPEPGLCEEALRPN-TTRPC----NTH 1568
Query: 1144 PCLLNENCFQFQYNLTEWSTCQLSENAPCGQGVRTRLLSCV-CSDGKP-VSMDQCEQHNL 1201
PC Q+ + W C + PCG GV+ RL+ CV G P DQC
Sbjct: 1569 PCT--------QWVVGPWGQC----SGPCGGGVQRRLVKCVNTQTGLPEEDSDQC----- 1611
Query: 1202 EKPQRMSIPCLVECVVNCQLSGWTAWTECSQTCG 1235
G AW E S+ CG
Sbjct: 1612 ---------------------GHEAWPESSRPCG 1624
Score = 58.9 bits (141), Expect = 4e-08
Identities = 45/147 (30%), Positives = 57/147 (38%), Gaps = 31/147 (21%)
Query: 556 PPPERKSCEIPCRMDCVLSEWTE-WSSCSQSCSNKNSDGKQTRSRTILALAGEGGKPCPP 614
P P + PC LS +T W CS++C G+Q R L E G C
Sbjct: 1505 PGPAKPPAHRPCGAQPCLSWYTSSWRECSEACGG----GEQQR----LVTCPEPGL-CEE 1555
Query: 615 SQALQEHRLCNDHSCMQLHWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFC 674
+ R CN H C Q W PWG CS CG G+Q R V C
Sbjct: 1556 ALRPNTTRPCNTHPCTQ--WVVGPWGQCS-----------------GPCGGGVQRRLVKC 1596
Query: 675 VKSHVG--QVMTKRCPDSTRPETVRPC 699
V + G + + +C PE+ RPC
Sbjct: 1597 VNTQTGLPEEDSDQCGHEAWPESSRPC 1623
Score = 55.1 bits (131), Expect = 5e-07
Identities = 52/196 (26%), Positives = 71/196 (36%), Gaps = 34/196 (17%)
Query: 1271 PCYSWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSIL 1330
P +SW G W+ C + CG GVQ +++ C + AG V++ C + D
Sbjct: 821 PVFSWHYGPWTKCTV---TCGRGVQRQNVYC------LERQAGPVDEEHCDPLGRPDDQQ 871
Query: 1331 KQLCSVPCPGDCHLTEW--SEWSTCELTCIDGRSFETVGRQSRSRTFIIQSFENQDSC-- 1386
++ PCP W EW C +C G RS QS +C
Sbjct: 872 RKCSEQPCP-----ARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEH 926
Query: 1387 -PQQVLETRPCTGGKCYHYTWKASLWN---------NNERTVWCQRSDGVNVTGGCSPQA 1436
P+ ET PC TW W+ R V C GV C
Sbjct: 927 LPRPPTET-PCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTGV----PCDEAQ 981
Query: 1437 RPAAIRQC-IPACRKP 1451
+PA+ C +P CR P
Sbjct: 982 QPASEVTCSLPLCRWP 997
Score = 52.0 bits (123), Expect = 5e-06
Identities = 43/180 (23%), Positives = 71/180 (39%), Gaps = 32/180 (17%)
Query: 1031 YSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQS 1090
+SW W+ C + CG G Q + + C+ + + G VD C+ P + Q
Sbjct: 823 FSWHYGPWTKCTVT-------CGRGVQRQNVYCL---ERQAGPVDEEHCDPLGRPDDQQR 872
Query: 1091 CSLMCPNECVMSEW--GLWSKCPQSCDPHTMQRRTRHLLRP-SLNSRTCAEDSQVQ---- 1143
C + + W G W C SC P + RR +R L+ ++ E +
Sbjct: 873 ---KCSEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPR 929
Query: 1144 -----PCLLNENCFQFQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQ 1198
PC + C + + WS C ++ CG+G + R + C G P D+ +Q
Sbjct: 930 PPTETPCNRHVPC-PATWAVGNWSQCSVT----CGEGTQRRNVLCTNDTGVP--CDEAQQ 982
Score = 51.6 bits (122), Expect = 6e-06
Identities = 43/137 (31%), Positives = 51/137 (37%), Gaps = 30/137 (21%)
Query: 15 AGPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLS----NCGESNRPPKERSCFRVCDWHS 70
AG W C+ CGPGG+ RAV C G + C RPP E C R +
Sbjct: 885 AGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPA 944
Query: 71 DLFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEH 130
W V +W C VT G Q R V C N T V C+
Sbjct: 945 ---TWAVGNWSQC----------------SVTCGEGTQRRNVLC---TNDTGVP---CDE 979
Query: 131 FALQPPTEQACLIPCPR 147
A QP +E C +P R
Sbjct: 980 -AQQPASEVTCSLPLCR 995
Score = 51.6 bits (122), Expect = 6e-06
Identities = 30/86 (34%), Positives = 39/86 (45%), Gaps = 13/86 (15%)
Query: 1222 SGWTA--WTECSQTCGHGGRMSRTRFIIMPTQG---EGRPCPTELTQEKTCPVTPCYSWV 1276
+GW A W+ECS TCG G R + GRP P + C + PC +W
Sbjct: 1413 AGWQAGNWSECSTTCGLGAVWRPVRCSSGRDEDCAPAGRPQPA-----RRCHLRPCATWH 1467
Query: 1277 LGNWSACKLEGGDCGEGVQIRSLSCM 1302
GNWS C CG G +R + C+
Sbjct: 1468 SGNWSKC---SRSCGGGSSVRDVQCV 1490
Score = 50.1 bits (118), Expect = 2e-05
Identities = 77/325 (23%), Positives = 112/325 (34%), Gaps = 92/325 (28%)
Query: 579 WSSCSQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHRLCNDHSCMQLHWETSP 638
WS CS +C G R + +G + C P+ Q R C+ C W +
Sbjct: 1420 WSECSTTC------GLGAVWRPVRCSSGRD-EDCAPAGRPQPARRCHLRPCAT--WHSGN 1470
Query: 639 WGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSH-VGQVMTKRC-PDSTRPETV 696
W CS +CG G R V CV + + + C P +P
Sbjct: 1471 WSKCSR-----------------SCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAH 1513
Query: 697 RPCFLPCKKDCIVTAFSEWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQECPDTLYEER 756
RPC + C+ S W C C G + R++ CP E
Sbjct: 1514 RPCGA---QPCLSWYTSSWRECSEACGGGE------QQRLVT---------CP----EPG 1551
Query: 757 ECEDVSLCPVYRWKPQKWSPCILVPESVWQ-GITGS-SEACGKGLQTRAVSCISDDNRSA 814
CE+ +P PC P + W G G S CG G+Q R V C++
Sbjct: 1552 LCEEAL-------RPNTTRPCNTHPCTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQ---- 1600
Query: 815 EMMECLKQTNGMPLLVQECTVPCREDCTFTAWSKFT-PCST-NCEATKSRRRQLTGKS-- 870
G+P +E + + C AW + + PC T +CE + R + S
Sbjct: 1601 ---------TGLP---EEDS----DQCGHEAWPESSRPCGTEDCEPVEPPRCERDRLSFG 1644
Query: 871 -----RKKEKCQDSDLYPLVETELC 890
R +CQ P + T+ C
Sbjct: 1645 FCETLRLLGRCQ----LPTIRTQCC 1665
Score = 47.4 bits (111), Expect = 1e-04
Identities = 59/252 (23%), Positives = 92/252 (36%), Gaps = 54/252 (21%)
Query: 1161 WSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHNLEKPQRMSI--PCLVECVVN 1218
WS C + CG G R + C S G+ + C +P R PC N
Sbjct: 1420 WSECSTT----CGLGAVWRPVRC--SSGRD---EDCAPAGRPQPARRCHLRPCATWHSGN 1470
Query: 1219 CQLSGWTAWTECSQTCGHGGRMSRTRFI----IMPTQG-EGRPCPTELTQEKTCPVTPCY 1273
W++CS++CG G + + + + P + +P P + + C PC
Sbjct: 1471 --------WSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPCL 1522
Query: 1274 SWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSILKQL 1333
SW +W C CG G Q R ++C E LC E + + +
Sbjct: 1523 SWYTSSWREC---SEACGGGEQQRLVTC-------------PEPGLC-EEALRPNTTRPC 1565
Query: 1334 CSVPCPGDCHLTEW--SEWSTCELTCIDGRSFETVGRQSRSRTFIIQSFENQDSCPQQVL 1391
+ PC T+W W C C G V + ++T + + E+ D C +
Sbjct: 1566 NTHPC------TQWVVGPWGQCSGPCGGGVQRRLV-KCVNTQTGLPE--EDSDQCGHEAW 1616
Query: 1392 --ETRPCTGGKC 1401
+RPC C
Sbjct: 1617 PESSRPCGTEDC 1628
Score = 46.2 bits (108), Expect = 2e-04
Identities = 53/211 (25%), Positives = 71/211 (33%), Gaps = 45/211 (21%)
Query: 15 AGPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSC-FRVC-DWHSDL 72
AG W C+ CG G V R V C + +C + RP R C R C WHS
Sbjct: 1417 AGNWSECSTTCGLGAVW-RPVRCS-----SGRDEDCAPAGRPQPARRCHLRPCATWHS-- 1468
Query: 73 FQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHFA 132
+W C + C G R V+C+ + + C+
Sbjct: 1469 -----GNWSKC-------------SRSC---GGGSSVRDVQCVDTRDLRPLRPFHCQPGP 1507
Query: 133 LQPPTEQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPNLTES 192
+PP + C + C+ W CS+ CG Q R P L PN T
Sbjct: 1508 AKPPAHRPC---GAQPCLSWYTSSWRECSEACGGGEQQRLVTCPEPGLCEEALRPNTT-- 1562
Query: 193 RACDAPISCPLGEEEYTFSLKVGPWSKCRLP 223
R C+ VGPW +C P
Sbjct: 1563 RPCNT---------HPCTQWVVGPWGQCSGP 1584
Score = 45.8 bits (107), Expect = 3e-04
Identities = 47/186 (25%), Positives = 66/186 (35%), Gaps = 48/186 (25%)
Query: 634 WETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRP 693
W PW C+ TCG G+Q + V+C++ G V + C RP
Sbjct: 825 WHYGPWTKCT-----------------VTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRP 867
Query: 694 -ETVRPCFLPCKKDCIVTAFS-EWTPCPRMCQAGNAT---VKQSRYRIIIQEAANGGQEC 748
+ R C ++ C ++ EW C C G + V R + +++A C
Sbjct: 868 DDQQRKC---SEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPAC 924
Query: 749 -----PDTLYEERECEDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRA 803
P T E C CP W WS C S CG+G Q R
Sbjct: 925 EHLPRPPT---ETPCNRHVPCPA-TWAVGNWSQC--------------SVTCGEGTQRRN 966
Query: 804 VSCISD 809
V C +D
Sbjct: 967 VLCTND 972
Score = 43.9 bits (102), Expect = 0.001
Identities = 56/227 (24%), Positives = 86/227 (37%), Gaps = 53/227 (23%)
Query: 735 RIIIQEAANGGQECPDTLYEERECEDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEA 794
+++ QE+ N G T++ E D PV+ W W+ C +
Sbjct: 792 QLLFQES-NPGVHYEYTIHREAGGHDEVPPPVFSWHYGPWTKCTV--------------T 836
Query: 795 CGKGLQTRAVSCISDDNRSAEMMECLKQTNGMPLLVQ-ECTVPCREDCTFTAWS-KFTPC 852
CG+G+Q + V C+ + C G P Q +C+ + C W+ ++ C
Sbjct: 837 CGRGVQRQNVYCLERQAGPVDEEHC--DPLGRPDDQQRKCS---EQPCPARWWAGEWQLC 891
Query: 853 STNC-EATKSRRRQLTGKSRKKEKCQDSDLYPLVETEL------CPCDEFISQP----YG 901
S++C SRR L +S + + S L P L PC+ + P G
Sbjct: 892 SSSCGPGGLSRRAVLCIRSVGLD--EQSALEPPACEHLPRPPTETPCNRHVPCPATWAVG 949
Query: 902 NWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSDKNGRPVD 948
NWS C S CGEG + R V C++ G P D
Sbjct: 950 NWSQC------------------SVTCGEGTQRRNVLCTNDTGVPCD 978
Score = 43.5 bits (101), Expect = 0.002
Identities = 43/178 (24%), Positives = 54/178 (30%), Gaps = 50/178 (28%)
Query: 634 WETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRP 693
W+ W CS TCG+G R V C + C + RP
Sbjct: 1415 WQAGNWSECS-----------------TTCGLGAVWRPVRCSSGR-----DEDCAPAGRP 1452
Query: 694 ETVRPCFLPCKKDCIVTAFSEWTPCPRMCQAGNAT-----VKQSRYRIIIQEAANGGQEC 748
+ R C L + C W+ C R C G++ V R + G
Sbjct: 1453 QPARRCHL---RPCATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAK 1509
Query: 749 PDTLYEERECEDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSC 806
P R C P W W C SEACG G Q R V+C
Sbjct: 1510 PPA---HRPC---GAQPCLSWYTSSWREC--------------SEACGGGEQQRLVTC 1547
Score = 43.5 bits (101), Expect = 0.002
Identities = 57/234 (24%), Positives = 78/234 (33%), Gaps = 57/234 (24%)
Query: 310 QWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEGELLQQCPR 369
Q +WS CS TC G++ R S + A G + C
Sbjct: 1416 QAGNWSECSTTCGLGAVWRPVRCSSGRDEDCAPAGRPQPARRCHLRPCA----------- 1464
Query: 370 YSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRP 429
+W + W +C S CGGG R+V C + RP
Sbjct: 1465 -TWHSGNWSKCSRS----------------CGGGSSVRDVQCVDT----------RDLRP 1497
Query: 430 VEKALC-VGPAPLPSQLCNIPCSTD-CIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVL 487
+ C GPA P+ + PC C+ S+W C E C G +QR V
Sbjct: 1498 LRPFHCQPGPAKPPA---HRPCGAQPCLSWYTSSWREC-SEAC-------GGGEQQRLVT 1546
Query: 488 MESTGPAGHCPHLVESVPCEDPMCYRWLASE-GICFPDHGKCGLG--HRILKAV 538
G + PC C +W+ G C G CG G R++K V
Sbjct: 1547 CPEPGLCEEALRPNTTRPCNTHPCTQWVVGPWGQC---SGPCGGGVQRRLVKCV 1597
Score = 42.7 bits (99), Expect = 0.003
Identities = 72/320 (22%), Positives = 108/320 (33%), Gaps = 69/320 (21%)
Query: 216 PWSKCRLPHLKEINPSGRTVLDFNSDSNERVTFKHQSYKAHHHSK-SWAIEIGYQTRQVS 274
P + R+P + + PS L + + ++ ++A + S+ S +G R V
Sbjct: 1382 PANSHRVPETQPLAPS----LAEAGPPADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVR 1437
Query: 275 CTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCETSQWSSWSPCSKTCRSGSLLPGFRS-- 332
C+ ++ C P + C + + C T +WS CS++C GS + +
Sbjct: 1438 CSSGRDED-----CAPAGRPQPARRCHL-RPCATWHSGNWSKCSRSCGGGSSVRDVQCVD 1491
Query: 333 ----RSRNVKHMAIGGGKECPELLEKEACIVEGELLQQCPRYSWRTSEWKECQVSLLLEQ 388
R H G K C + P SW TS W+EC
Sbjct: 1492 TRDLRPLRPFHCQPGPAKPPAH----RPCGAQ-------PCLSWYTSSWRECS------- 1533
Query: 389 QDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKALCVGPAPLPSQLCNI 448
CGGG Q R V C + ALR +RP C P C+
Sbjct: 1534 ---------EACGGGEQQRLVTCPEPGLCEEALR-PNTTRPCNTHPCTQWVVGPWGQCSG 1583
Query: 449 PCS-------TDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLV 501
PC C+ + + E D G + + ES+ P G
Sbjct: 1584 PCGGGVQRRLVKCVNTQTG-----LPEEDSDQCGHEAW--------PESSRPCG----TE 1626
Query: 502 ESVPCEDPMCYRWLASEGIC 521
+ P E P C R S G C
Sbjct: 1627 DCEPVEPPRCERDRLSFGFC 1646
Score = 40.4 bits (93), Expect = 0.014
Identities = 42/183 (22%), Positives = 54/183 (29%), Gaps = 35/183 (19%)
Query: 528 CGLGHRILKAVCQNDRGEDVSGSLCPV---PPPPERKSCEIPCRMDCVLSEWT--EWSSC 582
CG G + C + V C P +RK E PC + W EW C
Sbjct: 837 CGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCP-----ARWWAGEWQLC 891
Query: 583 SQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQALQE---HRLCNDHSCMQLHWETSPW 639
S SC + + L + P + L CN H W W
Sbjct: 892 SSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPATWAVGNW 951
Query: 640 GPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPETVRPC 699
CS TCG G Q R V C C ++ +P + C
Sbjct: 952 SQCS-----------------VTCGEGTQRRNVLCTND-----TGVPCDEAQQPASEVTC 989
Query: 700 FLP 702
LP
Sbjct: 990 SLP 992
Score = 40.4 bits (93), Expect = 0.014
Identities = 22/51 (43%), Positives = 27/51 (52%), Gaps = 3/51 (5%)
Query: 14 LAGPWGRCTGDCGPGGVQSRAVWCFHVD-GWTSHLSN-CGESNRPPKERSC 62
+ GPWG+C+G CG GGVQ R V C + G S+ CG P R C
Sbjct: 1574 VVGPWGQCSGPCG-GGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPC 1623
Score = 39.7 bits (91), Expect = 0.023
Identities = 43/160 (26%), Positives = 55/160 (34%), Gaps = 38/160 (23%)
Query: 15 AGPWGRCTGDCGPGGVQSRAVWCFHV-DGWTSHLSNCGESN-RPPKERSCFRVCDWHSDL 72
+G W +C+ CG GG R V C D +C +PP R C
Sbjct: 1468 SGNWSKCSRSCG-GGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGA-----QPC 1521
Query: 73 FQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHFA 132
W S W C G Q R+V C + +CE A
Sbjct: 1522 LSWYTSSWREC----------------SEACGGGEQQRLVTCPEP--------GLCEE-A 1556
Query: 133 LQPPTEQACLI-PCPRDCVVSEFLPWSNCSKGCGKKLQHR 171
L+P T + C PC + V PW CS CG +Q R
Sbjct: 1557 LRPNTTRPCNTHPCTQWVVG----PWGQCSGPCGGGVQRR 1592
Score = 37.4 bits (85), Expect = 0.12
Identities = 16/51 (31%), Positives = 28/51 (54%)
Query: 1222 SGWTAWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPTELTQEKTCPVTPC 1272
SGW+AW+ CS++CG G + + + + +GR C E + + C + C
Sbjct: 542 SGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQAC 592
Score = 36.2 bits (82), Expect = 0.26
Identities = 23/75 (30%), Positives = 32/75 (42%), Gaps = 6/75 (8%)
Query: 939 CSDKNGRPVDPSFCSSSGYIQEKCVIPCPF-----DCKLSDWSSWGSCSSSCGIGVRIRS 993
C K VD + C + + +P F D S WS+W CS SCG+GV+
Sbjct: 503 CHSKLDAAVDGTRCGENKWCLSGECVPVGFRPEAVDGGWSGWSAWSICSRSCGMGVQSAE 562
Query: 994 KWLKE-KPYNGGRPC 1007
+ + P GR C
Sbjct: 563 RQCTQPTPKYKGRYC 577
Score = 35.8 bits (81), Expect = 0.34
Identities = 58/277 (20%), Positives = 84/277 (30%), Gaps = 97/277 (35%)
Query: 368 PRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVS 427
P +SW W +C V+ CG G+Q + VYC + +
Sbjct: 821 PVFSWHYGPWTKCTVT----------------CGRGVQRQNVYCLE-----------RQA 853
Query: 428 RPVEKALCVGPAPLPSQLCNIPCSTDCIVSSWSA-WGLCIHENCHDPQGKKGFRTRQRHV 486
PV++ C P P C W+ W LC +C G +R+ +
Sbjct: 854 GPVDEEHC-DPLGRPDDQQRKCSEQPCPARWWAGEWQLC-SSSC-----GPGGLSRRAVL 906
Query: 487 LMESTGPAGHCPHLVESVPCEDPMCYRWLASEGICFPDHGKCGLGHRILKAVCQNDRGED 546
+ S G L E E P C +H
Sbjct: 907 CIRSVG-------LDEQSALEPPAC------------EH--------------------- 926
Query: 547 VSGSLCPVPPPPERKSC--EIPCRMDCVLSEWTEWSSCSQSCSNKNSDGKQTRSRTILAL 604
+P PP C +PC + WS CS +C G+ T+ R +L
Sbjct: 927 -------LPRPPTETPCNRHVPCPATWAVG---NWSQCSVTC------GEGTQRRNVLC- 969
Query: 605 AGEGGKPCPPSQALQEHRLCNDHSCMQLHWETSPWGP 641
+ G PC +Q C+ C W GP
Sbjct: 970 TNDTGVPCDEAQQPASEVTCSLPLC---RWPLGTLGP 1003
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.461
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 77,803,971
Number of Sequences: 37866
Number of extensions: 4102412
Number of successful extensions: 12378
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 53
Number of HSP's successfully gapped in prelim test: 49
Number of HSP's that attempted gapping in prelim test: 8665
Number of HSP's gapped (non-prelim): 1538
length of query: 1577
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1461
effective length of database: 13,855,062
effective search space: 20242245582
effective search space used: 20242245582
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.