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Search of human proteins with 28875786
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|28875786 FCH and double SH3 domains 1 [Homo sapiens]
(690 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|28875786 FCH and double SH3 domains 1 [Homo sapiens] 1379 0.0
gi|182765466 FCH and double SH3 domains 2 [Homo sapiens] 447 e-125
gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo sapi... 82 1e-15
gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a ... 73 8e-13
gi|11342676 thyroid hormone receptor interactor 10 [Homo sapiens] 73 8e-13
gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b ... 72 2e-12
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 70 7e-12
gi|156071465 Rho GTPase activating protein 4 [Homo sapiens] 68 2e-11
gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a... 68 3e-11
gi|112363096 SLIT-ROBO Rho GTPase activating protein 2 isoform b... 68 3e-11
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 62 2e-09
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 62 2e-09
gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens] 60 5e-09
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens] 60 5e-09
gi|5453754 NCK adaptor protein 1 [Homo sapiens] 59 2e-08
gi|11321634 CD2-associated protein [Homo sapiens] 59 2e-08
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 58 3e-08
gi|41581463 formin binding protein 1-like isoform 2 [Homo sapiens] 57 6e-08
gi|68348709 formin binding protein 1-like isoform 1 [Homo sapiens] 56 1e-07
gi|44662836 breast cancer anti-estrogen resistance 1 [Homo sapiens] 56 1e-07
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 55 2e-07
gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens] 55 2e-07
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 55 2e-07
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 55 2e-07
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 55 2e-07
gi|239745060 PREDICTED: similar to breast cancer anti-estrogen r... 55 3e-07
gi|38524622 formin binding protein 1 [Homo sapiens] 55 3e-07
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ... 54 4e-07
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s... 54 4e-07
gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Hom... 54 5e-07
>gi|28875786 FCH and double SH3 domains 1 [Homo sapiens]
Length = 690
Score = 1379 bits (3568), Expect = 0.0
Identities = 690/690 (100%), Positives = 690/690 (100%)
Query: 1 MQPPPRKVKPAQEVKLRFLEQLSILQTWQQREADLLEDIRSYSKQRAAIEREYGQALQKL 60
MQPPPRKVKPAQEVKLRFLEQLSILQTWQQREADLLEDIRSYSKQRAAIEREYGQALQKL
Sbjct: 1 MQPPPRKVKPAQEVKLRFLEQLSILQTWQQREADLLEDIRSYSKQRAAIEREYGQALQKL 60
Query: 61 AGPFLKREGHRSGEMDSRGRTVFGAWRCLLDATVAGGQTRLQASDRYRDLAGGTGRSAKE 120
AGPFLKREGHRSGEMDSRGRTVFGAWRCLLDATVAGGQTRLQASDRYRDLAGGTGRSAKE
Sbjct: 61 AGPFLKREGHRSGEMDSRGRTVFGAWRCLLDATVAGGQTRLQASDRYRDLAGGTGRSAKE 120
Query: 121 QVLRKGTENLQRAQAEVLQSVRELSRSRKLYGQRERVWALAQEKAADVQARLNRSDHGIF 180
QVLRKGTENLQRAQAEVLQSVRELSRSRKLYGQRERVWALAQEKAADVQARLNRSDHGIF
Sbjct: 121 QVLRKGTENLQRAQAEVLQSVRELSRSRKLYGQRERVWALAQEKAADVQARLNRSDHGIF 180
Query: 181 HSRTSLQKLSTKLSAQSAQYSQQLQAARNEYLLNLVATNAHLDHYYQEELPALLKALVSE 240
HSRTSLQKLSTKLSAQSAQYSQQLQAARNEYLLNLVATNAHLDHYYQEELPALLKALVSE
Sbjct: 181 HSRTSLQKLSTKLSAQSAQYSQQLQAARNEYLLNLVATNAHLDHYYQEELPALLKALVSE 240
Query: 241 LSEHLRDPLTSLSHTELEAAEVILEHAHRGEQTTSQVSWEQDLKLFLQEPGVFSPTPPQQ 300
LSEHLRDPLTSLSHTELEAAEVILEHAHRGEQTTSQVSWEQDLKLFLQEPGVFSPTPPQQ
Sbjct: 241 LSEHLRDPLTSLSHTELEAAEVILEHAHRGEQTTSQVSWEQDLKLFLQEPGVFSPTPPQQ 300
Query: 301 FQPAGTDQVCVLEWGAEGVAGKSGLEKEVQRLTSRAARDYKIQNHGHRVLQRLEQRRQQA 360
FQPAGTDQVCVLEWGAEGVAGKSGLEKEVQRLTSRAARDYKIQNHGHRVLQRLEQRRQQA
Sbjct: 301 FQPAGTDQVCVLEWGAEGVAGKSGLEKEVQRLTSRAARDYKIQNHGHRVLQRLEQRRQQA 360
Query: 361 SEREAPSIEQRLQEVRESIRRAQVSQVKGAARLALLQGAGLDVERWLKPAMTQAQDEVEQ 420
SEREAPSIEQRLQEVRESIRRAQVSQVKGAARLALLQGAGLDVERWLKPAMTQAQDEVEQ
Sbjct: 361 SEREAPSIEQRLQEVRESIRRAQVSQVKGAARLALLQGAGLDVERWLKPAMTQAQDEVEQ 420
Query: 421 ERRLSEARLSQRDLSPTAEDAELSDFEECEETGELFEEPAPQALATRALPCPAHVVFRYQ 480
ERRLSEARLSQRDLSPTAEDAELSDFEECEETGELFEEPAPQALATRALPCPAHVVFRYQ
Sbjct: 421 ERRLSEARLSQRDLSPTAEDAELSDFEECEETGELFEEPAPQALATRALPCPAHVVFRYQ 480
Query: 481 AGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFPDLSLPESSQDSDN 540
AGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFPDLSLPESSQDSDN
Sbjct: 481 AGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFPDLSLPESSQDSDN 540
Query: 541 PCGAEPTAFLAQALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGEFGGRVGVFP 600
PCGAEPTAFLAQALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGEFGGRVGVFP
Sbjct: 541 PCGAEPTAFLAQALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGEFGGRVGVFP 600
Query: 601 SLLVEELLGPPGPPELSDPEQMLPSPSPPSFSPPAPTSVLDGPPAPVLPGDKALDFPGFL 660
SLLVEELLGPPGPPELSDPEQMLPSPSPPSFSPPAPTSVLDGPPAPVLPGDKALDFPGFL
Sbjct: 601 SLLVEELLGPPGPPELSDPEQMLPSPSPPSFSPPAPTSVLDGPPAPVLPGDKALDFPGFL 660
Query: 661 DMMAPRLRPMRPPPPPPAKAPDPGHPDPLT 690
DMMAPRLRPMRPPPPPPAKAPDPGHPDPLT
Sbjct: 661 DMMAPRLRPMRPPPPPPAKAPDPGHPDPLT 690
>gi|182765466 FCH and double SH3 domains 2 [Homo sapiens]
Length = 740
Score = 447 bits (1149), Expect = e-125
Identities = 283/732 (38%), Positives = 414/732 (56%), Gaps = 62/732 (8%)
Query: 1 MQPPPRKVKPAQEVKLRFLEQLSILQTWQQREADLLEDIRSYSKQRAAIEREYGQALQKL 60
MQPPPRKVK QE+K +EQ++ LQ Q E DLLED+R++S+++AAIEREY Q +QKL
Sbjct: 1 MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKL 60
Query: 61 AGPFLKRE--GHRSGEMDSRGRTVFGAWRCLLDATVAGGQTRLQASDRYRDLAGG---TG 115
A +LKR+ G ++ + + R+++ W+ L+ T+ Q+R+ + Y++ T
Sbjct: 61 ASQYLKRDWPGVKADDRNDY-RSMYPVWKSFLEGTMQVAQSRMNICENYKNFISEPARTV 119
Query: 116 RSAKEQVLRKGTENLQRAQAEVLQSVRELSRSRKLYGQRERVWALAQEKAADVQARLNRS 175
RS KEQ L++ + L + Q E+ ++V++L++ +K Y + E++ +EKA D++A+ S
Sbjct: 120 RSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKA-DIEAKSKLS 178
Query: 176 DHGIFHSRTSLQKLSTKLSAQSAQYSQQLQAARNEYLLNLVATNAHLDHYYQEELPALLK 235
+F SR SLQK S KL A+ ++ + + ARN+YLL L A NAH D YYQ +L ++K
Sbjct: 179 ---LFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMK 235
Query: 236 ALVSELSEHLRDPLTSLSHTELEAAEVILEHAHRGEQTTSQVSWEQDLKLFLQEPGVFSP 295
AL + +HL+D L + S TELE + + + +S+V + +L+LFLQE VF
Sbjct: 236 ALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQENAVFHK 295
Query: 296 TPPQQFQPAGTDQVCVLEWGAEGVAGKSGLEKEVQRLTSRAARDYKIQNHGHRVLQRLEQ 355
P QFQP +D LE G + L KE ++ +R AR++K H RVL LE
Sbjct: 296 PQPFQFQPCDSDTSRQLE-SETGTTEEHSLNKEARKWATRVAREHKNIVHQQRVLNDLEC 354
Query: 356 RRQQASEREAPSIEQRLQEVRESIRRAQVSQVKGAARLALLQGAGLDVERWLKPAMTQAQ 415
SE+ +EQ++ E RE+IR+A++ ++K ARL LL+ G+ V+ WLK AM Q
Sbjct: 355 HGAAVSEQSRAELEQKIDEARENIRKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVM 414
Query: 416 DEVEQER-RLSEARLSQRDLSPTAEDAELSDFEECEETGELFEEPAPQALAT-RALPCPA 473
+E+E ER A S L D E + EE E+ ++F++ + T R P
Sbjct: 415 EELENERWARPPAVTSNGTLHSLNADTEREEGEEFEDNMDVFDDSSSSPSGTLRNYPLTC 474
Query: 474 HVVFRYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFPD----- 528
VV+ Y+A + DELTI E E LEVIE+GD ++WVKARN+ G+VG+VPE+YL FP
Sbjct: 475 KVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQFPTSNSLL 534
Query: 529 ------LSLPESSQDSDNPCGAE---------PTAFLAQALYSYTGQSAEELSFPEGALI 573
+L S S N AE + +ALY Y GQ+ +ELSFPEGA+I
Sbjct: 535 SMLQSLAALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTDDELSFPEGAII 594
Query: 574 RLLPRAQDGVDDGFWRGEFGGRVGVFPSLLVEEL-LGPPGPPELSDPEQMLPSPSPPSFS 632
R+L + ++ DDGFW GEF GR+GVFPS+LVEEL G Q+ PSP P +
Sbjct: 595 RILNK-ENQDDDGFWEGEFNGRIGVFPSVLVEELSASENGDTPWMREIQISPSPKPHASL 653
Query: 633 PPAPTSVLDGPPAPVLP----------------GDKAL--DFPGFL-------DMMAPRL 667
PP P + D PP+ P +K+L + PGF + +L
Sbjct: 654 PPLP--LYDQPPSSPYPSPDKRSSLYFPRSPSANEKSLHAESPGFSQASRHTPETSYGKL 711
Query: 668 RPMRPPPPPPAK 679
RP+R PPPP +
Sbjct: 712 RPVRAAPPPPTQ 723
>gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo
sapiens]
Length = 1085
Score = 82.4 bits (202), Expect = 1e-15
Identities = 93/364 (25%), Positives = 162/364 (44%), Gaps = 43/364 (11%)
Query: 12 QEVKLRFLEQLSILQTWQQREADLLEDIRSYSKQRAAIEREYGQALQKLAGPFLKR---- 67
+E++ + +EQ L+ + LL+D++ + +++A IE EY + L+KLA F+ +
Sbjct: 22 KEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIETEYSRNLEKLAERFMAKTRST 81
Query: 68 EGHRSGEMDSRGRTVFGAWRCLLDATVAGGQTRLQASDRYRDLAGGTGRSAKE---QVLR 124
+ H+ + D + W LL+ + SD Y + E ++ +
Sbjct: 82 KDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDIYLNNVIMRFMQISEDSTRMFK 141
Query: 125 KGTENLQRAQAEVLQSVRELSRSRKLYG--QRERVWALAQEKAADVQ--ARLNRSDHGIF 180
K E + ++++ + EL K Y E + A ++ K A+ Q ++ RS +F
Sbjct: 142 KSKEIAFQLHEDLMKVLNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQIGRSGDPVF 201
Query: 181 H--------SRTSLQKLSTKLSAQSAQYSQ-QLQA--ARNEYLLNLVATNAHLDHYYQEE 229
H R+S++K+ + A+YS+ +L++ ARNEYLL L ATNA + YY +
Sbjct: 202 HIRLEERHQRRSSVKKIEKMKEKRQAKYSENKLKSIKARNEYLLTLEATNASVFKYYIHD 261
Query: 230 LPALLKALVSELSEHLRDPLTSLSHTELEAAEVILEHAHRG----EQTTSQVSWEQDLKL 285
L L+ +L H L T L A + H G E + D +
Sbjct: 262 LSDLIDC--CDLGYHA--SLNRALRTYLSAEYNLETSRHEGLDIIENAVDNLEPRSDKQR 317
Query: 286 FLQ-EPGVFSPTPPQQFQPAGTDQVCVLEWGAEGVAGKSGLEKEV----QRLTSRAARDY 340
F++ P F P +FQ D+VC V+ + ++ E+ Q+L SR A
Sbjct: 318 FMEMYPAAFCPPMKFEFQSHMGDEVC-------QVSAQQPVQAELMLRYQQLQSRLA-TL 369
Query: 341 KIQN 344
KI+N
Sbjct: 370 KIEN 373
Score = 38.5 bits (88), Expect = 0.021
Identities = 43/163 (26%), Positives = 59/163 (36%), Gaps = 33/163 (20%)
Query: 532 PESSQDSDNPCGAEPTAFLAQALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGE 591
P +S+D P A A + Y G+SA ELSF +GA + L RA + +W G
Sbjct: 736 PHTSEDECEPIEAI-------AKFDYVGRSARELSFKKGASLLLYHRA----SEDWWEGR 784
Query: 592 FGGRVGVFPSLLVEELLGPPGPPELSDPEQMLPSPSPPSFSPPAPTSVLDGPPAPVLPGD 651
G G+ P + Q + + S A + GP
Sbjct: 785 HNGIDGLVPHQYI--------------VVQDMDDTFSDTLSQKADSEASSGPVTEDKSSS 830
Query: 652 KALDFP--GFLDMMAPRLRPMRPPPPP---PAKAPD---PGHP 686
K ++ P D R R PPPP P + D P HP
Sbjct: 831 KDMNSPTDRHPDGYLARQRKRGEPPPPVRRPGRTSDGHCPLHP 873
>gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a
[Homo sapiens]
Length = 1099
Score = 73.2 bits (178), Expect = 8e-13
Identities = 114/501 (22%), Positives = 195/501 (38%), Gaps = 53/501 (10%)
Query: 12 QEVKLRFLEQLSILQTWQQREADLLEDIRSYSKQRAAIEREYGQALQKLAGPF---LKRE 68
+E++ + +EQ L+ + LL+D++ + +++A IE EY ++L+KLA F ++
Sbjct: 22 KEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIELEYSRSLEKLAERFSSKIRSS 81
Query: 69 GHRSGEMDSRGRTVFGAWRCLLDATVAGGQTRLQASDRYRDLAGGTGRSAKEQVLR---K 125
+ D + W +L T + +D + + E V+R K
Sbjct: 82 REHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIFMNNVIVRLSQISEDVIRLFKK 141
Query: 126 GTENLQRAQAEVLQSVRELSRSRKLYG--QRERVWALAQEKAADVQARLNRSDHGIF--- 180
E + E+L+ EL K Y E + A ++ K A+ Q + G
Sbjct: 142 SKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQFNKSGDLSMN 201
Query: 181 --------HSRTSLQKLSTKLSAQSAQYSQ---QLQAARNEYLLNLVATNAHLDHYYQEE 229
R+S++K+ + A+YS+ + ARN+YLLNL ATNA + YY +
Sbjct: 202 LLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKARNDYLLNLAATNAAISKYYIHD 261
Query: 230 LPALLKALVSELSEHLRDPLTSLSHTELEAAEVILEHAHRG----EQTTSQVSWEQDLKL 285
+ L+ +L H L T L A + H G E + D
Sbjct: 262 VSDLIDC--CDLGFHA--SLARTFRTYLSAEYNLETSRHEGLDVIENAVDNLDSRSDKHT 317
Query: 286 FLQEPG-VFSPTPPQQFQPAGTDQVCVLEWGAEGVAGKSGLEKEV----QRLTSRAARDY 340
+ VF P +FQP D+VC V+ + ++ E+ +L SR A
Sbjct: 318 VMDMCNQVFCPPLKFEFQPHMGDEVC-------QVSAQQPVQTELLMRYHQLQSRLA-TL 369
Query: 341 KIQNHG-HRVLQRLEQRRQQASEREAPSIEQRLQEVR--ESIRRAQVSQVKGAARLALLQ 397
KI+N + L Q Q E + Q R ES++ A +A +
Sbjct: 370 KIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETYMSKINIAKRR 429
Query: 398 GAGLDVERWLKPAMTQAQDEVEQERRLSEARLSQRDLSPTAEDAELSDFEECEETGELFE 457
+ E + T+ ++ V +++ + L T + E + EC T
Sbjct: 430 ANQQETEMFY---FTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERA---ECGTTRPPCL 483
Query: 458 EPAPQAL-ATRALPCPAHVVF 477
P PQ + R L +H +F
Sbjct: 484 PPKPQKMRRPRPLSVYSHKLF 504
Score = 36.6 bits (83), Expect = 0.080
Identities = 28/87 (32%), Positives = 39/87 (44%), Gaps = 12/87 (13%)
Query: 521 ERYLNFPDLSLPESSQDSDNPCGAEPTA-------FLAQALYSYTGQSAEELSFPEGALI 573
E Y + P S P + + D+ G EP A A + Y G+S ELSF +GA +
Sbjct: 713 EEYCDSPH-SEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASL 771
Query: 574 RLLPRAQDGVDDGFWRGEFGGRVGVFP 600
L RA + +W G G G+ P
Sbjct: 772 LLYHRA----SEDWWEGRHNGVDGLIP 794
>gi|11342676 thyroid hormone receptor interactor 10 [Homo sapiens]
Length = 545
Score = 73.2 bits (178), Expect = 8e-13
Identities = 117/562 (20%), Positives = 214/562 (38%), Gaps = 87/562 (15%)
Query: 20 EQLSILQTWQQREADLLEDIRSYSKQRAAIEREYGQALQKLAGPFLKREGHRSGEMDSRG 79
+Q +L+ Q DLL+ + K+R +E+ Y + L+ L +L + + + +S+
Sbjct: 9 DQFEVLERHTQWGLDLLDRYVKFVKERTEVEQAYAKQLRSLVKKYLPKRPAKD-DPESKF 67
Query: 80 RTVFGAWRCLLDATVAGGQTRLQASDRYRDLAGGTGRSAKE--QVLRKGTENLQRAQAEV 137
+ L + GQ L A + + + ++E Q + + +RAQ ++
Sbjct: 68 SQQQSFVQILQEVNDFAGQRELVAENLSVRVCLELTKYSQEMKQERKMHFQEGRRAQQQL 127
Query: 138 LQSVRELSRSRKLYGQRERVWALAQEKAADVQARLNRSDHGIFHSRTSLQKLSTKLSAQS 197
++L S++ + + R EKAA RL D I ++ ++K Q+
Sbjct: 128 ENGFKQLENSKRKFERDCR----EAEKAAQTAERL---DQDINATKADVEKAKQ----QA 176
Query: 198 AQYSQQLQAARNEYLLNLVATNAHLDHYYQEELPALLKALVSELSEHLRDPLTS----LS 253
S + ++NEY L N H+Y ++P + L ++ E L + LS
Sbjct: 177 HLRSHMAEESKNEYAAQLQRFNRDQAHFYFSQMPQIFDKL-QDMDERRATRLGAGYGLLS 235
Query: 254 HTELEA-----------------------AEVILEHAHRGEQTTSQVSWEQDLKLFLQEP 290
ELE + V++E G V +E + + P
Sbjct: 236 EAELEVVPIIAKCLEGMKVAANAVDPKNDSHVLIELHKSGFARPGDVEFEDFSQPMNRAP 295
Query: 291 GVFSPTPPQQFQPA--GTDQVCVLEWGAEGVAGKSGLEKEVQRLTSRAARDYKIQNHGHR 348
S P +P G + W G K+ + ++ L R R
Sbjct: 296 SDSSLGTPSDGRPELRGPGRSRTKRWPF-GKKNKTVVTEDFSHLPPEQQRK--------R 346
Query: 349 VLQRLEQR----RQQASEREA-----------------PSIEQRLQEVRESIRRAQVSQV 387
+ Q+LE+R +++ +REA S+E ++ E +I R ++
Sbjct: 347 LQQQLEERSRELQKEVDQREALKKMKDVYEKTPQMGDPASLEPQIAETLSNIERLKLEVQ 406
Query: 388 KGAARLA-----LLQGAGLDVERWLKPAMTQAQDEVEQERRLSEARLSQRDLSPTAEDAE 442
K A LA +L G + R +P A + + + P +E+++
Sbjct: 407 KYEAWLAEAESRVLSNRGDSLSRHARPPDPPASAPPDSSSNSASQDTKESSEEPPSEESQ 466
Query: 443 LSDFEECEETGELFEEPAPQALATRALPCPAHVVFRYQAGREDELTITEGEWLEVIEEGD 502
D E E FEE + C A ++ ++ E +++ EGE L ++EE
Sbjct: 467 --DTPIYTEFDEDFEEEPTSPIGH----CVA--IYHFEGSSEGTISMAEGEDLSLMEEDK 518
Query: 503 ADEWVKARNQHGEVGFVPERYL 524
D W + R + G G+VP YL
Sbjct: 519 GDGWTRVRRKEGGEGYVPTSYL 540
>gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b
[Homo sapiens]
Length = 1075
Score = 72.0 bits (175), Expect = 2e-12
Identities = 79/326 (24%), Positives = 133/326 (40%), Gaps = 31/326 (9%)
Query: 12 QEVKLRFLEQLSILQTWQQREADLLEDIRSYSKQRAAIEREYGQALQKLAGPF---LKRE 68
+E++ + +EQ L+ + LL+D++ + +++A IE EY ++L+KLA F ++
Sbjct: 22 KEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIELEYSRSLEKLAERFSSKIRSS 81
Query: 69 GHRSGEMDSRGRTVFGAWRCLLDATVAGGQTRLQASDRYRDLAGGTGRSAKEQVLR---K 125
+ D + W +L T + +D + + E V+R K
Sbjct: 82 REHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIFMNNVIVRLSQISEDVIRLFKK 141
Query: 126 GTENLQRAQAEVLQSVRELSRSRKLYG--QRERVWALAQEKAADVQARLNRSDHGIF--- 180
E + E+L+ EL K Y E + A ++ K A+ Q + G
Sbjct: 142 SKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQFNKSGDLSMN 201
Query: 181 --------HSRTSLQKLSTKLSAQSAQYSQ---QLQAARNEYLLNLVATNAHLDHYYQEE 229
R+S++K+ + A+YS+ + ARN+YLLNL ATNA + YY +
Sbjct: 202 LLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKARNDYLLNLAATNAAISKYYIHD 261
Query: 230 LPALLKALVSELSEHLRDPLTSLSHTELEAAEVILEHAHRG----EQTTSQVSWEQDLKL 285
+ L+ +L H L T L A + H G E + D
Sbjct: 262 VSDLIDC--CDLGFHA--SLARTFRTYLSAEYNLETSRHEGLDVIENAVDNLDSRSDKHT 317
Query: 286 FLQEPG-VFSPTPPQQFQPAGTDQVC 310
+ VF P +FQP D+VC
Sbjct: 318 VMDMCNQVFCPPLKFEFQPHMGDEVC 343
Score = 36.6 bits (83), Expect = 0.080
Identities = 28/87 (32%), Positives = 39/87 (44%), Gaps = 12/87 (13%)
Query: 521 ERYLNFPDLSLPESSQDSDNPCGAEPTA-------FLAQALYSYTGQSAEELSFPEGALI 573
E Y + P S P + + D+ G EP A A + Y G+S ELSF +GA +
Sbjct: 689 EEYCDSPH-SEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASL 747
Query: 574 RLLPRAQDGVDDGFWRGEFGGRVGVFP 600
L RA + +W G G G+ P
Sbjct: 748 LLYHRA----SEDWWEGRHNGVDGLIP 770
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 70.1 bits (170), Expect = 7e-12
Identities = 51/179 (28%), Positives = 86/179 (48%), Gaps = 18/179 (10%)
Query: 475 VVFRYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFPDLSL--- 531
V+ Y+A +EDEL++ G+ + + A W++ G G PER + +L
Sbjct: 5 VLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFG-GRYGLFPERLVQEIPETLRGS 63
Query: 532 -----PESSQDSDNPCGAEPTAFLAQALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDG 586
P ++ +P + +SY+ + A+EL G ++ ++ ++DG
Sbjct: 64 GEARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKE----IEDG 119
Query: 587 FWRGEFGGRVGVFPSLLVEELLGPPGPPELSDPEQMLPSPSPPSFSPPAPTSV-LDGPP 644
+W G+ G++G FPS VE L GPP L +P+ +PS SP PP +S+ D PP
Sbjct: 120 WWLGKKNGQLGAFPSNFVELL--DSGPPSLGNPD--MPSVSPGPQRPPKLSSLAYDSPP 174
Score = 60.8 bits (146), Expect = 4e-09
Identities = 47/181 (25%), Positives = 80/181 (44%), Gaps = 30/181 (16%)
Query: 475 VVFRYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNF-----PDL 529
V F Y + DEL + GE +E+I+E + W+ +N G++G P ++ P L
Sbjct: 90 VNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKN--GQLGAFPSNFVELLDSGPPSL 147
Query: 530 SLPESSQDSDNPCGAEPTAFLA-----------------QALYSYTGQSAEELSFPEGAL 572
P+ S P + LA + L+ Y ++ +EL+ G +
Sbjct: 148 GNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRGDV 207
Query: 573 IRLLPRAQDGVDDGFWRGEFGGRVGVFPSLLVEELLGPPGPPELSDPEQMLPSPSPPSFS 632
+++L + + D G+W GE GR GVFP + + PP P + P +++ S P
Sbjct: 208 VKVLSKTTE--DKGWWEGECQGRRGVFP----DNFVLPPPPIKKLVPRKVVSRESAPIKE 261
Query: 633 P 633
P
Sbjct: 262 P 262
>gi|156071465 Rho GTPase activating protein 4 [Homo sapiens]
Length = 946
Score = 68.2 bits (165), Expect = 2e-11
Identities = 69/254 (27%), Positives = 118/254 (46%), Gaps = 37/254 (14%)
Query: 12 QEVKLRFLEQLSILQTWQQREADLLEDIRSYSKQRAAIEREYGQALQKLAGPFLKREG-- 69
+E++ + EQL L+ + +LL+++ + ++RA +E EY + L+KLA F R G
Sbjct: 22 KEMRWQLSEQLRCLELQGELRRELLQELAEFMRRRAEVELEYSRGLEKLAERFSSRGGRL 81
Query: 70 -----HRSGEMDSRGRTVFGAWRCLLDATVAGGQTRLQASD--------RYRDLAGGTGR 116
H+S + + W LL T + S+ R +A GR
Sbjct: 82 GSSREHQSFRKEPSLLSPLHCWAVLLQHTRQQSRESAALSEVLAGPLAQRLSHIAEDVGR 141
Query: 117 SAKEQVLRKGTENLQRAQAEVLQSVRELSRSRKLYG--QRERVWALAQEKAADVQ--ARL 172
+++K + Q+ Q E+L+ V EL ++K Y E V A A+ + A+ Q R
Sbjct: 142 -----LVKKSRDLEQQLQDELLEVVSELQTAKKTYQAYHMESVNAEAKLREAERQEEKRA 196
Query: 173 NRS---------DHGIFHSRTSLQK---LSTKLSAQSAQYSQQLQAARNEYLLNLVATNA 220
RS + G ++SL+K L K A+ ++ + ARNEYLL+L + NA
Sbjct: 197 GRSVPTTTAGATEAGPLR-KSSLKKGGRLVEKRQAKFMEHKLKCTKARNEYLLSLASVNA 255
Query: 221 HLDHYYQEELPALL 234
+ +YY ++ L+
Sbjct: 256 AVSNYYLHDVLDLM 269
Score = 44.7 bits (104), Expect = 3e-04
Identities = 28/76 (36%), Positives = 40/76 (52%), Gaps = 9/76 (11%)
Query: 525 NFPDLSLPESSQDSDNPCGAEPTAFLAQALYSYTGQSAEELSFPEGALIRLLPRAQDGVD 584
N P+L +Q+ D E A A ++YTG++A+ELSF G ++RL RA
Sbjct: 730 NEPELEAEMPAQEDDLEGVVE-----AVACFAYTGRTAQELSFRRGDVLRLHERA----S 780
Query: 585 DGFWRGEFGGRVGVFP 600
+WRGE G G+ P
Sbjct: 781 SDWWRGEHNGMRGLIP 796
Score = 35.8 bits (81), Expect = 0.14
Identities = 49/190 (25%), Positives = 67/190 (35%), Gaps = 30/190 (15%)
Query: 477 FRYQAGREDELTITEGEWLEVIEEGDADEWVKARNQH-GEVGFVPERYLNFP---DLSLP 532
F Y EL+ G+ L + E +D W R +H G G +P +Y+ P + +
Sbjct: 755 FAYTGRTAQELSFRRGDVLRLHERASSDWW---RGEHNGMRGLIPHKYITLPAGTEKQVV 811
Query: 533 ESSQDSDNPCGAEPTAFLAQAL-YSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGE 591
+ + G+ P LA L + ++ E P G R L A +
Sbjct: 812 GAGLQTAGESGSSPEGLLASELVHRPEPCTSPEAMGPSGHRRRCLVPASPEQHVEVDKAV 871
Query: 592 FGGRVGVFPSLL----VEELLGPPGPPELSDPEQMLPSPSPPSFSPPAPTS--------V 639
VF LL V + LGP SPSP SP AP S
Sbjct: 872 AQNMDSVFKELLGKTSVRQGLGPAS----------TTSPSPGPRSPKAPPSSRLGRNKGF 921
Query: 640 LDGPPAPVLP 649
GP AP P
Sbjct: 922 SRGPGAPASP 931
>gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a
[Homo sapiens]
Length = 1071
Score = 67.8 bits (164), Expect = 3e-11
Identities = 94/386 (24%), Positives = 160/386 (41%), Gaps = 76/386 (19%)
Query: 12 QEVKLRFLEQLSILQTWQQREADLLEDIRSYSKQRAAIEREYGQALQKLAGPFLKREGHR 71
+E++ + EQ+ L + LL+D++ + +++A IE +Y + L+KLA FL +
Sbjct: 22 KEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTRST 81
Query: 72 SGEMDSRGRTVFG---AWRCLLDATVAGGQTRLQASD--------RYRDLAGGTGRSAKE 120
+ + + V W LL+ + SD R+ ++ +GR
Sbjct: 82 KDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGR---- 137
Query: 121 QVLRKGTENLQRAQAEVLQSVRELSRSRKLYGQRERVWALAQEKAADVQAR--------L 172
+ +K E Q+ Q ++++ + EL K Y AQ K + + + +
Sbjct: 138 -LFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSV 196
Query: 173 NRSDHGIFHS---------------RTSLQKLSTKLSAQSAQYSQ-QLQA--ARNEYLLN 214
+ D S R+S++K+ + A+Y++ +L+A ARNEYLL
Sbjct: 197 KQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLA 256
Query: 215 LVATNAHLDHYYQEELPALL-------------KALVSELSEHLRDPLTSLSHTELEAAE 261
L ATNA + YY +L L+ +AL + LS L L H L+A
Sbjct: 257 LEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAELN--LEQSKHEGLDA-- 312
Query: 262 VILEHAHRGEQTTSQVSWEQDLKLFLQEPGVFSPTPPQQFQPAGTD---QVCVLEWGAEG 318
+E+A TS +L VF P +FQP D Q+C +
Sbjct: 313 --IENAVENLDATSDKQ-----RLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQ----- 360
Query: 319 VAGKSGLEKEVQRLTSRAARDYKIQN 344
+S L + Q+L SR + KI+N
Sbjct: 361 -PVQSELVQRCQQLQSRLS-TLKIEN 384
Score = 42.7 bits (99), Expect = 0.001
Identities = 34/107 (31%), Positives = 50/107 (46%), Gaps = 15/107 (14%)
Query: 530 SLPESSQD-------SDNPCGAEPTAFLAQALYSYTGQSAEELSFPEGALIRLLPRAQDG 582
S+ +S+QD SD+ C EP +A+ + Y G++A ELSF +GA + L RA
Sbjct: 709 SVEDSTQDVTAEHHTSDDEC--EPIEAIAK--FDYVGRTARELSFKKGASLLLYQRA--- 761
Query: 583 VDDGFWRGEFGGRVGVFPSLLVEELLGPPGPPELSDPEQMLPSPSPP 629
D +W G G G+ P + G E S P+ + S P
Sbjct: 762 -SDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVISEP 807
>gi|112363096 SLIT-ROBO Rho GTPase activating protein 2 isoform b
[Homo sapiens]
Length = 836
Score = 67.8 bits (164), Expect = 3e-11
Identities = 94/386 (24%), Positives = 160/386 (41%), Gaps = 76/386 (19%)
Query: 12 QEVKLRFLEQLSILQTWQQREADLLEDIRSYSKQRAAIEREYGQALQKLAGPFLKREGHR 71
+E++ + EQ+ L + LL+D++ + +++A IE +Y + L+KLA FL +
Sbjct: 22 KEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTRST 81
Query: 72 SGEMDSRGRTVFG---AWRCLLDATVAGGQTRLQASD--------RYRDLAGGTGRSAKE 120
+ + + V W LL+ + SD R+ ++ +GR
Sbjct: 82 KDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGR---- 137
Query: 121 QVLRKGTENLQRAQAEVLQSVRELSRSRKLYGQRERVWALAQEKAADVQAR--------L 172
+ +K E Q+ Q ++++ + EL K Y AQ K + + + +
Sbjct: 138 -LFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSV 196
Query: 173 NRSDHGIFHS---------------RTSLQKLSTKLSAQSAQYSQ-QLQA--ARNEYLLN 214
+ D S R+S++K+ + A+Y++ +L+A ARNEYLL
Sbjct: 197 KQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLA 256
Query: 215 LVATNAHLDHYYQEELPALL-------------KALVSELSEHLRDPLTSLSHTELEAAE 261
L ATNA + YY +L L+ +AL + LS L L H L+A
Sbjct: 257 LEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAELN--LEQSKHEGLDA-- 312
Query: 262 VILEHAHRGEQTTSQVSWEQDLKLFLQEPGVFSPTPPQQFQPAGTD---QVCVLEWGAEG 318
+E+A TS +L VF P +FQP D Q+C +
Sbjct: 313 --IENAVENLDATSDKQ-----RLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQ----- 360
Query: 319 VAGKSGLEKEVQRLTSRAARDYKIQN 344
+S L + Q+L SR + KI+N
Sbjct: 361 -PVQSELVQRCQQLQSRLS-TLKIEN 384
Score = 42.7 bits (99), Expect = 0.001
Identities = 34/107 (31%), Positives = 50/107 (46%), Gaps = 15/107 (14%)
Query: 530 SLPESSQD-------SDNPCGAEPTAFLAQALYSYTGQSAEELSFPEGALIRLLPRAQDG 582
S+ +S+QD SD+ C EP +A+ + Y G++A ELSF +GA + L RA
Sbjct: 709 SVEDSTQDVTAEHHTSDDEC--EPIEAIAK--FDYVGRTARELSFKKGASLLLYQRA--- 761
Query: 583 VDDGFWRGEFGGRVGVFPSLLVEELLGPPGPPELSDPEQMLPSPSPP 629
D +W G G G+ P + G E S P+ + S P
Sbjct: 762 -SDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVISEP 807
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 61.6 bits (148), Expect = 2e-09
Identities = 40/138 (28%), Positives = 71/138 (51%), Gaps = 11/138 (7%)
Query: 473 AHVVFRYQAGREDELTITEGEWLEVIEEGDADEW---VKARNQHGEVGFVPERYLNFPDL 529
A V+ Y A ++LT+ G+ + + ++ W ++AR + ++G+ P Y+ L
Sbjct: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKL--L 1136
Query: 530 SLPESSQDSDNPCGAEPTAFLAQAL--YSYTGQSAEELSFPEGALIRLLPRAQDGVDDGF 587
S S P + A + Q + Y YT Q+ +EL+F +G +I +L + D +
Sbjct: 1137 SPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKE----DPDW 1192
Query: 588 WRGEFGGRVGVFPSLLVE 605
W+GE G+VG+FPS V+
Sbjct: 1193 WKGEVNGQVGLFPSNYVK 1210
Score = 45.4 bits (106), Expect = 2e-04
Identities = 40/150 (26%), Positives = 68/150 (45%), Gaps = 17/150 (11%)
Query: 476 VFRYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFPDLSLPESS 535
++ Y++ + +LT +G+ + V ++ D D W + G P Y+ D S +
Sbjct: 1010 MYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTVGD--KAGVFPSNYVRLKD-SEGSGT 1065
Query: 536 QDSDNPCGAEPTAFLAQALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGEFGGR 595
G +P +AQ + SYT E+L+ G LI L+ + G G+W GE R
Sbjct: 1066 AGKTGSLGKKPE--IAQVIASYTATGPEQLTLAPGQLI-LIRKKNPG---GWWEGELQAR 1119
Query: 596 -----VGVFPSLLVEELLGPPGPPELSDPE 620
+G FP+ V+ L PG +++ E
Sbjct: 1120 GKKRQIGWFPANYVKLL--SPGTSKITPTE 1147
Score = 42.7 bits (99), Expect = 0.001
Identities = 34/143 (23%), Positives = 65/143 (45%), Gaps = 22/143 (15%)
Query: 473 AHVVFRYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFPDLSLP 532
A ++ ++A +++ L + + + V+E+ D W Q G+ G+ P+ Y+ +
Sbjct: 918 AQALYPWRAKKDNHLNFNKNDVITVLEQQDM--WWFGEVQ-GQKGWFPKSYVKLISGPIR 974
Query: 533 ES----SQDSDNPCGAEPTAFLAQ----------ALYSYTGQSAEELSFPEGALIRLLPR 578
+S S S++P + A A A+Y+Y +L+F +G +I + +
Sbjct: 975 KSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKK 1034
Query: 579 AQDGVDDGFWRGEFGGRVGVFPS 601
D +W G G + GVFPS
Sbjct: 1035 -----DGDWWTGTVGDKAGVFPS 1052
Score = 42.4 bits (98), Expect = 0.001
Identities = 78/359 (21%), Positives = 144/359 (40%), Gaps = 78/359 (21%)
Query: 333 TSRAARDYKIQNHGHRVLQRLEQRRQQASEREAPS---IEQRLQEVRE-SIRRAQVSQVK 388
++ +R+ +I H LQ+ Q QQ R P + +L++V++ S+ R + +K
Sbjct: 512 STNKSRELRIAEITH--LQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLK 569
Query: 389 GAARLALLQGAGLDVERWLKPAMTQAQDEVEQERRLSEARLSQRDLSPTAEDAELSDFEE 448
A L+ + + + DEVE+E R ++L + D+ + +L + E
Sbjct: 570 RA----------LEAKELARQHLRDQLDEVEKETR---SKLQEIDIF----NNQLKELRE 612
Query: 449 CEETGELFEEPAPQALATRALPCPAHVVFRYQAGREDELTITEGE--WLEVIEEGDADEW 506
+L ++ + +A + ++ + E + E + WLE +++ DE
Sbjct: 613 IHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQ--EDEH 670
Query: 507 VKARNQHGEVGFVPERYLNFPDLSLPESSQDSDNPCG--------------------AE- 545
+ R H E E + D + Q++ + G AE
Sbjct: 671 QRPRKLHEEEKLKREESVKKKD-GEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEK 729
Query: 546 -PTAFLAQ---------ALYSYTGQSAEELSFPEGALIRL----LPRAQDGVDDGFWRGE 591
P AQ ALY + +S +E++ G ++ + + +Q G + G+ GE
Sbjct: 730 GPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTG-EPGWLGGE 788
Query: 592 FGGRVGVFPSLLVEELLGPPGPPELSDPEQMLPSPSPP---SFSPPAPTSVLDGPPAPV 647
G+ G FP+ E++ PE +P+P P S S PAP L PAP+
Sbjct: 789 LKGKTGWFPANYAEKI-----------PENEVPAPVKPVTDSTSAPAPKLALRETPAPL 836
Score = 41.6 bits (96), Expect = 0.002
Identities = 111/528 (21%), Positives = 195/528 (36%), Gaps = 67/528 (12%)
Query: 164 KAADVQARLNRSDHGIFHSRTSLQKLSTKLS--AQSAQYSQQL--QAARNEYLLNLVATN 219
K D++ RL I + S + +++ Q Q SQQ+ + + +LN
Sbjct: 495 KLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQ 554
Query: 220 AHLDHYYQEELPALLKAL-VSELS-EHLRDPLTSL---SHTELEAAEVI------LEHAH 268
+ +++ L L +AL EL+ +HLRD L + + ++L+ ++ L H
Sbjct: 555 VQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIH 614
Query: 269 RGEQTTSQVSWEQD-LKLFLQEPGVFSPTPPQQFQPAGTDQVCVLEWGAEGVAGKSGLEK 327
+Q Q S E + LK QE + Q+ + Q +W E V E
Sbjct: 615 NKQQLQKQKSMEAERLKQKEQERKIIE-LEKQKEEAQRRAQERDKQW-LEHVQQ----ED 668
Query: 328 EVQRLTSRAARDYKIQNHGHRVLQRLEQRRQQASEREAPSIEQRLQEVRESIRRAQVSQV 387
E QR + + + E+ +Q+A ++ Q + + +++ +
Sbjct: 669 EHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAE 728
Query: 388 KGAARLALLQGAGLDVERWLKPAMTQAQDEVE-QERRLSEARLSQRDLSPTAEDAELSDF 446
KG ++ + + R L P +++ DE+ Q + + D S T E L
Sbjct: 729 KGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGG- 787
Query: 447 EECEETGEL----------FEEPAPQALATRALPCPAHVVFRYQ-----AGREDELTITE 491
E +TG E PAP T + PA + + A E + T
Sbjct: 788 ELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTP 847
Query: 492 GEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFPDLSLPESSQDSDNPC-------GA 544
W + + W + N+ E + + P L++P + Q G+
Sbjct: 848 NNWADF-----SSTWPTSTNEKPETDNW-DAWAAQPSLTVPSAGQLRQRSAFTPATATGS 901
Query: 545 EPTAFL----------AQALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGEFGG 594
P+ L AQALY + + L+F + +I +L + D +W GE G
Sbjct: 902 SPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQ-----QDMWWFGEVQG 956
Query: 595 RVGVFPSLLVEELLGPPGPPELSDPEQMLPSPSPPSFSPPAPTSVLDG 642
+ G FP V+ + GP D S + PA V+ G
Sbjct: 957 QKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSG 1004
Score = 36.6 bits (83), Expect = 0.080
Identities = 21/73 (28%), Positives = 36/73 (49%), Gaps = 3/73 (4%)
Query: 452 TGELFEEPAPQALATRALPCPAHVVFRYQAGREDELTITEGEWLEVIEEGDADEWVKARN 511
T ++ P++ A A+ C ++ Y A +DEL +G+ + V+ + D D W N
Sbjct: 1140 TSKITPTEPPKSTALAAV-CQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVN 1198
Query: 512 QHGEVGFVPERYL 524
G+VG P Y+
Sbjct: 1199 --GQVGLFPSNYV 1209
Score = 29.6 bits (65), Expect = 9.8
Identities = 29/114 (25%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 321 GKSGLEKEVQRLTSRAARDYKIQNHGHRVLQRLEQRRQQASEREAP-SIEQRLQEVRESI 379
G LEK Q L + ++ + R Q ++R +Q ER+ +E++L++ RE
Sbjct: 361 GNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELE 420
Query: 380 RRAQVSQVKGAARLALLQGAGLDVERWLKPAMTQAQDEVEQERRLSEARLSQRD 433
R+ + + K R + A ++ER Q ++E ER + L+QR+
Sbjct: 421 RQREEERRKEIER---REAAKRELER---------QRQLEWERNRRQELLNQRN 462
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 61.6 bits (148), Expect = 2e-09
Identities = 40/138 (28%), Positives = 71/138 (51%), Gaps = 11/138 (7%)
Query: 473 AHVVFRYQAGREDELTITEGEWLEVIEEGDADEW---VKARNQHGEVGFVPERYLNFPDL 529
A V+ Y A ++LT+ G+ + + ++ W ++AR + ++G+ P Y+ L
Sbjct: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKL--L 1136
Query: 530 SLPESSQDSDNPCGAEPTAFLAQAL--YSYTGQSAEELSFPEGALIRLLPRAQDGVDDGF 587
S S P + A + Q + Y YT Q+ +EL+F +G +I +L + D +
Sbjct: 1137 SPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKE----DPDW 1192
Query: 588 WRGEFGGRVGVFPSLLVE 605
W+GE G+VG+FPS V+
Sbjct: 1193 WKGEVNGQVGLFPSNYVK 1210
Score = 45.4 bits (106), Expect = 2e-04
Identities = 40/150 (26%), Positives = 68/150 (45%), Gaps = 17/150 (11%)
Query: 476 VFRYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFPDLSLPESS 535
++ Y++ + +LT +G+ + V ++ D D W + G P Y+ D S +
Sbjct: 1010 MYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTVGD--KAGVFPSNYVRLKD-SEGSGT 1065
Query: 536 QDSDNPCGAEPTAFLAQALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGEFGGR 595
G +P +AQ + SYT E+L+ G LI L+ + G G+W GE R
Sbjct: 1066 AGKTGSLGKKPE--IAQVIASYTATGPEQLTLAPGQLI-LIRKKNPG---GWWEGELQAR 1119
Query: 596 -----VGVFPSLLVEELLGPPGPPELSDPE 620
+G FP+ V+ L PG +++ E
Sbjct: 1120 GKKRQIGWFPANYVKLL--SPGTSKITPTE 1147
Score = 42.7 bits (99), Expect = 0.001
Identities = 34/143 (23%), Positives = 65/143 (45%), Gaps = 22/143 (15%)
Query: 473 AHVVFRYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFPDLSLP 532
A ++ ++A +++ L + + + V+E+ D W Q G+ G+ P+ Y+ +
Sbjct: 918 AQALYPWRAKKDNHLNFNKNDVITVLEQQDM--WWFGEVQ-GQKGWFPKSYVKLISGPIR 974
Query: 533 ES----SQDSDNPCGAEPTAFLAQ----------ALYSYTGQSAEELSFPEGALIRLLPR 578
+S S S++P + A A A+Y+Y +L+F +G +I + +
Sbjct: 975 KSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKK 1034
Query: 579 AQDGVDDGFWRGEFGGRVGVFPS 601
D +W G G + GVFPS
Sbjct: 1035 -----DGDWWTGTVGDKAGVFPS 1052
Score = 42.4 bits (98), Expect = 0.001
Identities = 78/359 (21%), Positives = 144/359 (40%), Gaps = 78/359 (21%)
Query: 333 TSRAARDYKIQNHGHRVLQRLEQRRQQASEREAPS---IEQRLQEVRE-SIRRAQVSQVK 388
++ +R+ +I H LQ+ Q QQ R P + +L++V++ S+ R + +K
Sbjct: 512 STNKSRELRIAEITH--LQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLK 569
Query: 389 GAARLALLQGAGLDVERWLKPAMTQAQDEVEQERRLSEARLSQRDLSPTAEDAELSDFEE 448
A L+ + + + DEVE+E R ++L + D+ + +L + E
Sbjct: 570 RA----------LEAKELARQHLRDQLDEVEKETR---SKLQEIDIF----NNQLKELRE 612
Query: 449 CEETGELFEEPAPQALATRALPCPAHVVFRYQAGREDELTITEGE--WLEVIEEGDADEW 506
+L ++ + +A + ++ + E + E + WLE +++ DE
Sbjct: 613 IHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQ--EDEH 670
Query: 507 VKARNQHGEVGFVPERYLNFPDLSLPESSQDSDNPCG--------------------AE- 545
+ R H E E + D + Q++ + G AE
Sbjct: 671 QRPRKLHEEEKLKREESVKKKD-GEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEK 729
Query: 546 -PTAFLAQ---------ALYSYTGQSAEELSFPEGALIRL----LPRAQDGVDDGFWRGE 591
P AQ ALY + +S +E++ G ++ + + +Q G + G+ GE
Sbjct: 730 GPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTG-EPGWLGGE 788
Query: 592 FGGRVGVFPSLLVEELLGPPGPPELSDPEQMLPSPSPP---SFSPPAPTSVLDGPPAPV 647
G+ G FP+ E++ PE +P+P P S S PAP L PAP+
Sbjct: 789 LKGKTGWFPANYAEKI-----------PENEVPAPVKPVTDSTSAPAPKLALRETPAPL 836
Score = 41.6 bits (96), Expect = 0.002
Identities = 111/528 (21%), Positives = 195/528 (36%), Gaps = 67/528 (12%)
Query: 164 KAADVQARLNRSDHGIFHSRTSLQKLSTKLS--AQSAQYSQQL--QAARNEYLLNLVATN 219
K D++ RL I + S + +++ Q Q SQQ+ + + +LN
Sbjct: 495 KLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQ 554
Query: 220 AHLDHYYQEELPALLKAL-VSELS-EHLRDPLTSL---SHTELEAAEVI------LEHAH 268
+ +++ L L +AL EL+ +HLRD L + + ++L+ ++ L H
Sbjct: 555 VQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIH 614
Query: 269 RGEQTTSQVSWEQD-LKLFLQEPGVFSPTPPQQFQPAGTDQVCVLEWGAEGVAGKSGLEK 327
+Q Q S E + LK QE + Q+ + Q +W E V E
Sbjct: 615 NKQQLQKQKSMEAERLKQKEQERKIIE-LEKQKEEAQRRAQERDKQW-LEHVQQ----ED 668
Query: 328 EVQRLTSRAARDYKIQNHGHRVLQRLEQRRQQASEREAPSIEQRLQEVRESIRRAQVSQV 387
E QR + + + E+ +Q+A ++ Q + + +++ +
Sbjct: 669 EHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAE 728
Query: 388 KGAARLALLQGAGLDVERWLKPAMTQAQDEVE-QERRLSEARLSQRDLSPTAEDAELSDF 446
KG ++ + + R L P +++ DE+ Q + + D S T E L
Sbjct: 729 KGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGG- 787
Query: 447 EECEETGEL----------FEEPAPQALATRALPCPAHVVFRYQ-----AGREDELTITE 491
E +TG E PAP T + PA + + A E + T
Sbjct: 788 ELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTP 847
Query: 492 GEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFPDLSLPESSQDSDNPC-------GA 544
W + + W + N+ E + + P L++P + Q G+
Sbjct: 848 NNWADF-----SSTWPTSTNEKPETDNW-DAWAAQPSLTVPSAGQLRQRSAFTPATATGS 901
Query: 545 EPTAFL----------AQALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGEFGG 594
P+ L AQALY + + L+F + +I +L + D +W GE G
Sbjct: 902 SPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQ-----QDMWWFGEVQG 956
Query: 595 RVGVFPSLLVEELLGPPGPPELSDPEQMLPSPSPPSFSPPAPTSVLDG 642
+ G FP V+ + GP D S + PA V+ G
Sbjct: 957 QKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSG 1004
Score = 37.0 bits (84), Expect = 0.061
Identities = 24/88 (27%), Positives = 39/88 (44%), Gaps = 3/88 (3%)
Query: 452 TGELFEEPAPQALATRALPCPAHVVFRYQAGREDELTITEGEWLEVIEEGDADEWVKARN 511
T ++ P++ A A+ C ++ Y A +DEL +G+ + V+ + D D W N
Sbjct: 1140 TSKITPTEPPKSTALAAV-CQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVN 1198
Query: 512 QHGEVGFVPERYLNFPDLSLPESSQDSD 539
G+VG P Y+ P SD
Sbjct: 1199 --GQVGLFPSNYVKLTTDMDPSQQWCSD 1224
Score = 29.6 bits (65), Expect = 9.8
Identities = 29/114 (25%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 321 GKSGLEKEVQRLTSRAARDYKIQNHGHRVLQRLEQRRQQASEREAP-SIEQRLQEVRESI 379
G LEK Q L + ++ + R Q ++R +Q ER+ +E++L++ RE
Sbjct: 361 GNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELE 420
Query: 380 RRAQVSQVKGAARLALLQGAGLDVERWLKPAMTQAQDEVEQERRLSEARLSQRD 433
R+ + + K R + A ++ER Q ++E ER + L+QR+
Sbjct: 421 RQREEERRKEIER---REAAKRELER---------QRQLEWERNRRQELLNQRN 462
>gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]
Length = 752
Score = 60.5 bits (145), Expect = 5e-09
Identities = 91/393 (23%), Positives = 165/393 (41%), Gaps = 41/393 (10%)
Query: 24 ILQTWQQREADLLEDIRSYSKQRAAIEREYGQALQKLAGPFLKREGHRSGEMDSRGRTVF 83
+LQ Q+ E LLE +R + QR +REY L ++ L+ G +S + S +
Sbjct: 15 VLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMS---LQDSGGQSRAI-SPDSPIS 70
Query: 84 GAWRCLLDATVAGGQTRLQASDRYRDLAGGTGRSAKEQVLRKGTENLQRAQAEVLQSVRE 143
+W + T G +RL DL +G +K +L + + L++ +E Q +++
Sbjct: 71 QSWAEITSQT--EGLSRL-LRQHAEDL--NSGPLSKLSLLIRERQQLRKTYSEQWQQLQQ 125
Query: 144 ---LSRSRKLYGQRERVWALAQEKAADVQARLNRSDHGIFHSRTSLQKLSTKLSAQSAQY 200
+ S+ + + + ALA++ A QA+ + S K K + +
Sbjct: 126 ELTKTHSQDIEKLKSQYRALARDSA---QAKRK-------YQEASKDKDRDKAKDKYVRS 175
Query: 201 SQQLQAARNEYLLNLVATNAHLDHYYQEELPALLKALVSELSEHLRDPLTSLSHTELEAA 260
+L A N Y+L + A H H++Q LP LL++L +L E + L + LE +
Sbjct: 176 LWKLFAHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSL-QDLHEEMACILKEILQEYLEIS 234
Query: 261 EVILEHA---HRG-EQTTSQVSWEQDLKLFLQEPGVFSPTPP---------QQFQPAGTD 307
++ + HR +++ E + + FL++ G PP ++ +P
Sbjct: 235 SLVQDEVVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPG 294
Query: 308 QVCVLEWGAEGVAGKSGLEKEVQRLTSRAARDYKIQNHGHRVLQRLEQRRQQASEREAPS 367
++ + E E V + L L ++ Q ++ Q L + RE
Sbjct: 295 ELQLNELTVESV--QHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQ 352
Query: 368 I---EQRLQEVRESIRRAQVSQVKGAARLALLQ 397
+ Q LQE + ++ A SQ K A+ LLQ
Sbjct: 353 LLGKRQVLQEALQGLQVALCSQAKLQAQQELLQ 385
>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
Length = 822
Score = 60.5 bits (145), Expect = 5e-09
Identities = 91/393 (23%), Positives = 165/393 (41%), Gaps = 41/393 (10%)
Query: 24 ILQTWQQREADLLEDIRSYSKQRAAIEREYGQALQKLAGPFLKREGHRSGEMDSRGRTVF 83
+LQ Q+ E LLE +R + QR +REY L ++ L+ G +S + S +
Sbjct: 15 VLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMS---LQDSGGQSRAI-SPDSPIS 70
Query: 84 GAWRCLLDATVAGGQTRLQASDRYRDLAGGTGRSAKEQVLRKGTENLQRAQAEVLQSVRE 143
+W + T G +RL DL +G +K +L + + L++ +E Q +++
Sbjct: 71 QSWAEITSQT--EGLSRL-LRQHAEDL--NSGPLSKLSLLIRERQQLRKTYSEQWQQLQQ 125
Query: 144 ---LSRSRKLYGQRERVWALAQEKAADVQARLNRSDHGIFHSRTSLQKLSTKLSAQSAQY 200
+ S+ + + + ALA++ A QA+ + S K K + +
Sbjct: 126 ELTKTHSQDIEKLKSQYRALARDSA---QAKRK-------YQEASKDKDRDKAKDKYVRS 175
Query: 201 SQQLQAARNEYLLNLVATNAHLDHYYQEELPALLKALVSELSEHLRDPLTSLSHTELEAA 260
+L A N Y+L + A H H++Q LP LL++L +L E + L + LE +
Sbjct: 176 LWKLFAHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSL-QDLHEEMACILKEILQEYLEIS 234
Query: 261 EVILEHA---HRG-EQTTSQVSWEQDLKLFLQEPGVFSPTPP---------QQFQPAGTD 307
++ + HR +++ E + + FL++ G PP ++ +P
Sbjct: 235 SLVQDEVVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPG 294
Query: 308 QVCVLEWGAEGVAGKSGLEKEVQRLTSRAARDYKIQNHGHRVLQRLEQRRQQASEREAPS 367
++ + E E V + L L ++ Q ++ Q L + RE
Sbjct: 295 ELQLNELTVESV--QHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQ 352
Query: 368 I---EQRLQEVRESIRRAQVSQVKGAARLALLQ 397
+ Q LQE + ++ A SQ K A+ LLQ
Sbjct: 353 LLGKRQVLQEALQGLQVALCSQAKLQAQQELLQ 385
>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
Length = 377
Score = 58.9 bits (141), Expect = 2e-08
Identities = 52/185 (28%), Positives = 85/185 (45%), Gaps = 19/185 (10%)
Query: 469 LPCPAHVVFRYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERY----- 523
L PA+V F Y A REDEL++ +G + V+E+ +D W + + +G+VG+ P Y
Sbjct: 107 LNMPAYVKFNYMAEREDELSLIKGTKVIVMEK-CSDGWWRG-SYNGQVGWFPSNYVTEEG 164
Query: 524 ---LNFPDLSLPESSQDSDNPCGAEPTAFLAQALYSYTGQSAEELSFPEGALIRLLPRAQ 580
L SL E N + QALY ++ + EEL+F +G ++ ++ + +
Sbjct: 165 DSPLGDHVGSLSEKLAAVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPE 224
Query: 581 DGVDDGFWR-GEFGGRVGVFPSLLVEELLGPPGPPELSDPEQMLPSPSPPSFSPPAPTSV 639
+ D +W+ + G VG+ P V + P L PSP + P+ T
Sbjct: 225 N--DPEWWKCRKINGMVGLVPKNYVTVMQNNPLTSGLE------PSPPQCDYIRPSLTGK 276
Query: 640 LDGPP 644
G P
Sbjct: 277 FAGNP 281
Score = 57.4 bits (137), Expect = 4e-08
Identities = 45/159 (28%), Positives = 72/159 (45%), Gaps = 36/159 (22%)
Query: 477 FRYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYL------------ 524
F Y A +E EL I + E L +++ D+ W + RN + GFVP Y+
Sbjct: 11 FDYVAQQEQELDIKKNERLWLLD--DSKSWWRVRNSMNKTGFVPSNYVERKNSARKASIV 68
Query: 525 -NFPDL----------SLPESSQDSDNPCGAEPTAFL------AQALYSYTGQSAEELSF 567
N D S+P+S+ +D+ +P L A ++Y + +ELS
Sbjct: 69 KNLKDTLGIGKVKRKPSVPDSASPADDSF-VDPGERLYDLNMPAYVKFNYMAEREDELSL 127
Query: 568 PEGALIRLLPRAQDGVDDGFWRGEFGGRVGVFPSLLVEE 606
+G + ++ + DG +WRG + G+VG FPS V E
Sbjct: 128 IKGTKVIVMEKCSDG----WWRGSYNGQVGWFPSNYVTE 162
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 58.5 bits (140), Expect = 2e-08
Identities = 43/150 (28%), Positives = 68/150 (45%), Gaps = 27/150 (18%)
Query: 552 QALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGEFGGRVGVFP---SLLVEELL 608
+ L++Y G + +EL+F EG +I L+ +++ + G+WRGE G+ GVFP ++ + EL
Sbjct: 275 RTLFAYEGTNEDELTFKEGEIIHLI--SKETGEAGWWRGELNGKEGVFPDNFAVQINELD 332
Query: 609 GPPGPPELSDPEQMLPSPSPP---------SFSP------------PAPTSVLDGPPAPV 647
P+ P P+P P S P P+ + PP
Sbjct: 333 KDFPKPKKPPPPAKAPAPKPELIAAEKKYFSLKPEEKDEKSTLEQKPSKPAAPQVPPKKP 392
Query: 648 LPGDKALDFPGFLDMMAPRLRPMRPPPPPP 677
P KA + + P+ RP +P PPPP
Sbjct: 393 TPPTKASNLLRSSGTVYPK-RPEKPVPPPP 421
Score = 48.5 bits (114), Expect = 2e-05
Identities = 46/190 (24%), Positives = 78/190 (41%), Gaps = 40/190 (21%)
Query: 475 VVFRYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYL-------NFP 527
V + Y A +DELTI GE + +++ + W++ +G G P+ ++ F
Sbjct: 6 VEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEG-ELNGRRGMFPDNFVKEIKRETEFK 64
Query: 528 DLSLPESSQDSDN-------------PCGA------------EPTAFLAQALYSYTGQSA 562
D SLP + N P G + + L+ Y Q+
Sbjct: 65 DDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNE 124
Query: 563 EELSFPEGALIRLLPRAQDGVDDGFWRGEFGGRVGVFPSLLVEEL-LGPPGPPE--LSDP 619
+EL G +I + + V++G+W G ++G+FPS V+EL + G D
Sbjct: 125 DELELKVGDIIDI----NEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDS 180
Query: 620 EQMLPSPSPP 629
E +L P+ P
Sbjct: 181 ETVLAGPTSP 190
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 58.2 bits (139), Expect = 3e-08
Identities = 47/176 (26%), Positives = 75/176 (42%), Gaps = 29/176 (16%)
Query: 473 AHVVFRYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFPDLSL- 531
A V F YQA +DELTI+ GE + I + D W N G G P+ ++ +
Sbjct: 4 AIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQIN--GRRGLFPDNFVREIKKEMK 61
Query: 532 --PESSQDSDNPCGAEPTA--------------------FLAQALYSYTGQSAEELSFPE 569
P +++ + P P+ Q +SY Q+ +EL
Sbjct: 62 KDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKV 121
Query: 570 GALIRLLPRAQDGVDDGFWRGEFGGRVGVFPSLLVEELLGPPGPPELSDPEQMLPS 625
G +I ++ V++G+W G G+ G+FPS ++EL G +S EQ+ S
Sbjct: 122 GDIIEVVGE----VEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKS 173
Score = 52.0 bits (123), Expect = 2e-06
Identities = 44/149 (29%), Positives = 68/149 (45%), Gaps = 15/149 (10%)
Query: 552 QALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGEFGGRVGVFPSLLVEELLGPP 611
+ ++ Y Q+ +EL+ EG ++ L+ + D +D G+W GE GR GVFP V +LL P
Sbjct: 273 KVIFPYEAQNDDELTIKEGDIVTLINK--DCIDVGWWEGELNGRRGVFPDNFV-KLLPPD 329
Query: 612 GPPELSDPEQMLPSPSPPSFSPPAPTS-----VLDGPP--APVLPG----DKALDFPGFL 660
E + P++ P PS P A T+ + PP +LP + + L
Sbjct: 330 FEKEGNRPKKP-PPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKL 388
Query: 661 DMMAPRLRPMRPPPPPPAKAPDPGHPDPL 689
D+ P + + P P P K P L
Sbjct: 389 DLQKPSVPAIPPKKPRPPKTNSLSRPGAL 417
Score = 34.7 bits (78), Expect = 0.30
Identities = 21/67 (31%), Positives = 34/67 (50%), Gaps = 3/67 (4%)
Query: 475 VVFRYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFPDLSLPES 534
V+F Y+A +DELTI EG+ + +I + D +G G P+ NF L P+
Sbjct: 274 VIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPD---NFVKLLPPDF 330
Query: 535 SQDSDNP 541
++ + P
Sbjct: 331 EKEGNRP 337
>gi|41581463 formin binding protein 1-like isoform 2 [Homo sapiens]
Length = 547
Score = 57.0 bits (136), Expect = 6e-08
Identities = 112/571 (19%), Positives = 214/571 (37%), Gaps = 84/571 (14%)
Query: 20 EQLSILQTWQQREADLLEDIRSYSKQRAAIEREYGQALQKLAGPFLKREGHRSGEMDSRG 79
+Q L Q D LE + K+R IE+ Y + L+ L + + + E R
Sbjct: 9 DQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPKRSSKDEE--PRF 66
Query: 80 RTVFGAWRCLLDATVAGGQTRLQASDRYRDLAGGTGRSAKEQVLRKGT--ENLQRAQAEV 137
+ + L + GQ + A + + G R A + + + ++AQ +
Sbjct: 67 TSCVAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLKTERKMHLQEGRKAQQYL 126
Query: 138 LQSVRELSRSRKLYGQRERVWALAQEKAADVQARLNRSDHGIFHSRTSLQKLSTKLSAQS 197
+++ S+K + + R +A Q R D+ ++ ++K +L+ ++
Sbjct: 127 DMCWKQMDNSKKKFERECR-------EAEKAQQSYERLDNDTNATKADVEKAKQQLNLRT 179
Query: 198 AQYSQQLQAARNEYLLNLVATNAHLDHYYQEELPALLKALVSELSEH----LRDPLTSLS 253
+ +NEY L N ++ +P + K L E+ E L + +
Sbjct: 180 HMADEN----KNEYAAQLQNFNGEQHKHFYVVIPQIYKQL-QEMDERRTIKLSECYRGFA 234
Query: 254 HTELEAAEVILEHAHRGEQTTSQVSWEQDLKLFLQE-PGVFSPTPPQQFQPA-------- 304
+E + +I + V +D ++ + F P F+
Sbjct: 235 DSERKVIPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYRTI 294
Query: 305 --GTDQVCVLEWG---AEGVAGKS--------------GLE-----------KEVQRLTS 334
GT E G A+ GK+ LE K++Q+
Sbjct: 295 SDGTISASKQESGKMDAKTTVGKAKGKLWLFGKKPKGPALEDFSHLPPEQRRKKLQQRID 354
Query: 335 RAARDYKIQNHGHRVLQRLEQRRQQASEREAP-SIEQRLQEVRESIRRAQVSQVKGAARL 393
R+ + ++ L +++ ++ + P S++ +L E +I R ++ K A L
Sbjct: 355 ELNRELQKESDQKDALNKMKDVYEKNPQMGDPGSLQPKLAETMNNIDRLRMEIHKNEAWL 414
Query: 394 ALLQGAGLDVERWLKPAMTQAQDEVEQERRLSEARLS----QRDLSPTAEDAELSDFEEC 449
+ ++G R + + V Q R E + Q P + ++F++
Sbjct: 415 SEVEGK--TGGRGDRRHSSDINHLVTQGRESPEGSYTDDANQEVRGPPQQHGHHNEFDD- 471
Query: 450 EETGELFEEPAPQALATRALPCPAH--VVFRYQAGREDELTITEGEWLEVIEEGDADEWV 507
FE+ P LP H ++ + E L + EGE L +IEE D W
Sbjct: 472 -----EFEDDDP-------LPAIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWT 519
Query: 508 KARNQHGEVGFVPERYLNFPDLSLPESSQDS 538
+AR Q+GE G+VP Y+ D++L ++S+ S
Sbjct: 520 RARRQNGEEGYVPTSYI---DVTLEKNSKGS 547
>gi|68348709 formin binding protein 1-like isoform 1 [Homo sapiens]
Length = 551
Score = 55.8 bits (133), Expect = 1e-07
Identities = 111/569 (19%), Positives = 213/569 (37%), Gaps = 84/569 (14%)
Query: 20 EQLSILQTWQQREADLLEDIRSYSKQRAAIEREYGQALQKLAGPFLKREGHRSGEMDSRG 79
+Q L Q D LE + K+R IE+ Y + L+ L + + + E R
Sbjct: 9 DQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPKRSSKDEE--PRF 66
Query: 80 RTVFGAWRCLLDATVAGGQTRLQASDRYRDLAGGTGRSAKEQVLRKGT--ENLQRAQAEV 137
+ + L + GQ + A + + G R A + + + ++AQ +
Sbjct: 67 TSCVAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLKTERKMHLQEGRKAQQYL 126
Query: 138 LQSVRELSRSRKLYGQRERVWALAQEKAADVQARLNRSDHGIFHSRTSLQKLSTKLSAQS 197
+++ S+K + + R +A Q R D+ ++ ++K +L+ ++
Sbjct: 127 DMCWKQMDNSKKKFERECR-------EAEKAQQSYERLDNDTNATKADVEKAKQQLNLRT 179
Query: 198 AQYSQQLQAARNEYLLNLVATNAHLDHYYQEELPALLKALVSELSEH----LRDPLTSLS 253
+ +NEY L N ++ +P + K L E+ E L + +
Sbjct: 180 HMADEN----KNEYAAQLQNFNGEQHKHFYVVIPQIYKQL-QEMDERRTIKLSECYRGFA 234
Query: 254 HTELEAAEVILEHAHRGEQTTSQVSWEQDLKLFLQE-PGVFSPTPPQQFQPA-------- 304
+E + +I + V +D ++ + F P F+
Sbjct: 235 DSERKVIPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYRTI 294
Query: 305 --GTDQVCVLEWG---AEGVAGKS--------------GLE-----------KEVQRLTS 334
GT E G A+ GK+ LE K++Q+
Sbjct: 295 SDGTISASKQESGKMDAKTTVGKAKGKLWLFGKKPKGPALEDFSHLPPEQRRKKLQQRID 354
Query: 335 RAARDYKIQNHGHRVLQRLEQRRQQASEREAP-SIEQRLQEVRESIRRAQVSQVKGAARL 393
R+ + ++ L +++ ++ + P S++ +L E +I R ++ K A L
Sbjct: 355 ELNRELQKESDQKDALNKMKDVYEKNPQMGDPGSLQPKLAETMNNIDRLRMEIHKNEAWL 414
Query: 394 ALLQGAGLDVERWLKPAMTQAQDEVEQERRLSEARLS----QRDLSPTAEDAELSDFEEC 449
+ ++G R + + V Q R E + Q P + ++F++
Sbjct: 415 SEVEGK--TGGRGDRRHSSDINHLVTQGRESPEGSYTDDANQEVRGPPQQHGHHNEFDD- 471
Query: 450 EETGELFEEPAPQALATRALPCPAH--VVFRYQAGREDELTITEGEWLEVIEEGDADEWV 507
FE+ P LP H ++ + E L + EGE L +IEE D W
Sbjct: 472 -----EFEDDDP-------LPAIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWT 519
Query: 508 KARNQHGEVGFVPERYLNFPDLSLPESSQ 536
+AR Q+GE G+VP Y+ D++L ++S+
Sbjct: 520 RARRQNGEEGYVPTSYI---DVTLEKNSK 545
>gi|44662836 breast cancer anti-estrogen resistance 1 [Homo sapiens]
Length = 870
Score = 55.8 bits (133), Expect = 1e-07
Identities = 43/153 (28%), Positives = 70/153 (45%), Gaps = 15/153 (9%)
Query: 550 LAQALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGEFGGRVGVFPSLLVEELLG 609
LA+ALY +S +ELSF +G ++ +L + G+ DG+W GR G+ P ++ L+G
Sbjct: 7 LAKALYDNVAESPDELSFRKGDIMTVLEQDTQGL-DGWWLCSLHGRQGIVPGNRLKILVG 65
Query: 610 ---------PPGPPEL-SDPEQMLPSPSPPS--FSPPAPTSVLDGPPAPVLPGDKALDFP 657
PGPP + P+ L +P+PP+ ++P P + P + L +
Sbjct: 66 MYDKKPAGPGPGPPATPAQPQPGLHAPAPPASQYTPMLPNTYQPQPDSVYLVPTPSKAQQ 125
Query: 658 GFLDMMAPRLRPMRPPPPPPA--KAPDPGHPDP 688
G + P + PP + P HP P
Sbjct: 126 GLYQVPGPSPQFQSPPAKQTSTFSKQTPHHPFP 158
>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 55.1 bits (131), Expect = 2e-07
Identities = 60/212 (28%), Positives = 95/212 (44%), Gaps = 31/212 (14%)
Query: 428 RLSQRDLSPT-AEDAELSDFEECEETGELFEEPAPQALATRA--LPCPAHVVFRYQAGRE 484
+ S RD SPT + DAE PA + A R L PA V F Y A RE
Sbjct: 83 KTSARDASPTPSTDAEY---------------PANGSGADRIYDLNIPAFVKFAYVAERE 127
Query: 485 DELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERY-LNFPDLSLPESSQDSDNPCG 543
DEL++ +G + V+E+ +D W + + +G++G+ P Y L D + ES G
Sbjct: 128 DELSLVKGSRVTVMEK-CSDGWWRG-SYNGQIGWFPSNYVLEEVDEAAAESPSFLSLRKG 185
Query: 544 A-------EPTAFLAQALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGEFG-GR 595
A + Q LY ++ + EEL+F +G + ++ + ++ D +W+ + G+
Sbjct: 186 ASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPEN--DPEWWKCKNARGQ 243
Query: 596 VGVFPSLLVEELLGPPGPPELSDPEQMLPSPS 627
VG+ P V L P P+ PS
Sbjct: 244 VGLVPKNYVVVLSDGPALHPAHAPQISYTGPS 275
Score = 51.2 bits (121), Expect = 3e-06
Identities = 42/161 (26%), Positives = 70/161 (43%), Gaps = 39/161 (24%)
Query: 479 YQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYL-------------N 525
Y A ++ EL I + E L +++ D+ W + RN G+VP Y+ N
Sbjct: 13 YTAQQDQELDIKKNERLWLLD--DSKTWWRVRNAANRTGYVPSNYVERKNSLKKGSLVKN 70
Query: 526 FPDL--------------SLPESSQDSDNPC---GAEPTAFL---AQALYSYTGQSAEEL 565
D + P S D++ P GA+ L A ++Y + +EL
Sbjct: 71 LKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAEREDEL 130
Query: 566 SFPEGALIRLLPRAQDGVDDGFWRGEFGGRVGVFPSLLVEE 606
S +G+ + ++ + DG+WRG + G++G FPS V E
Sbjct: 131 SLVKGSRVTVMEKC----SDGWWRGSYNGQIGWFPSNYVLE 167
>gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 55.1 bits (131), Expect = 2e-07
Identities = 60/212 (28%), Positives = 95/212 (44%), Gaps = 31/212 (14%)
Query: 428 RLSQRDLSPT-AEDAELSDFEECEETGELFEEPAPQALATRA--LPCPAHVVFRYQAGRE 484
+ S RD SPT + DAE PA + A R L PA V F Y A RE
Sbjct: 83 KTSARDASPTPSTDAEY---------------PANGSGADRIYDLNIPAFVKFAYVAERE 127
Query: 485 DELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERY-LNFPDLSLPESSQDSDNPCG 543
DEL++ +G + V+E+ +D W + + +G++G+ P Y L D + ES G
Sbjct: 128 DELSLVKGSRVTVMEK-CSDGWWRG-SYNGQIGWFPSNYVLEEVDEAAAESPSFLSLRKG 185
Query: 544 A-------EPTAFLAQALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGEFG-GR 595
A + Q LY ++ + EEL+F +G + ++ + ++ D +W+ + G+
Sbjct: 186 ASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPEN--DPEWWKCKNARGQ 243
Query: 596 VGVFPSLLVEELLGPPGPPELSDPEQMLPSPS 627
VG+ P V L P P+ PS
Sbjct: 244 VGLVPKNYVVVLSDGPALHPAHAPQISYTGPS 275
Score = 51.2 bits (121), Expect = 3e-06
Identities = 42/161 (26%), Positives = 70/161 (43%), Gaps = 39/161 (24%)
Query: 479 YQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYL-------------N 525
Y A ++ EL I + E L +++ D+ W + RN G+VP Y+ N
Sbjct: 13 YTAQQDQELDIKKNERLWLLD--DSKTWWRVRNAANRTGYVPSNYVERKNSLKKGSLVKN 70
Query: 526 FPDL--------------SLPESSQDSDNPC---GAEPTAFL---AQALYSYTGQSAEEL 565
D + P S D++ P GA+ L A ++Y + +EL
Sbjct: 71 LKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAEREDEL 130
Query: 566 SFPEGALIRLLPRAQDGVDDGFWRGEFGGRVGVFPSLLVEE 606
S +G+ + ++ + DG+WRG + G++G FPS V E
Sbjct: 131 SLVKGSRVTVMEKC----SDGWWRGSYNGQIGWFPSNYVLE 167
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 55.1 bits (131), Expect = 2e-07
Identities = 40/137 (29%), Positives = 65/137 (47%), Gaps = 29/137 (21%)
Query: 479 YQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFPDLSLPESSQDS 538
+ A D+L+ G+ ++++E D+D W + R Q E G P ++
Sbjct: 613 FTAETSDDLSFKRGDRIQILERLDSD-WCRGRLQDRE-GIFPAVFVR------------- 657
Query: 539 DNPCGAEPTAFLA--------QALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRG 590
PC AE + LA +ALY + G++ +ELSF G +I L + VDD + G
Sbjct: 658 --PCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITEL----ESVDDDWMSG 711
Query: 591 EFGGRVGVFPSLLVEEL 607
E G+ G+FP ++ L
Sbjct: 712 ELMGKSGIFPKNYIQFL 728
Score = 54.7 bits (130), Expect = 3e-07
Identities = 40/134 (29%), Positives = 66/134 (49%), Gaps = 8/134 (5%)
Query: 473 AHVVFRYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFPDLSLP 532
A V+ + A + D+L +T GE + ++E+ D D W + N ++G P Y+ + +P
Sbjct: 441 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTD-WYRG-NCRNQIGIFPANYVKVI-IDIP 497
Query: 533 ESSQDSDNPCGAEPT-AFLAQALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGE 591
E + A + Y G+ +ELSF EG +I L ++ V++ + RGE
Sbjct: 498 EGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIIL----KEYVNEEWARGE 553
Query: 592 FGGRVGVFPSLLVE 605
GR G+FP VE
Sbjct: 554 VRGRTGIFPLNFVE 567
Score = 53.9 bits (128), Expect = 5e-07
Identities = 41/162 (25%), Positives = 78/162 (48%), Gaps = 25/162 (15%)
Query: 477 FRYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYL-----------N 525
F Y ++DEL+ +EGE + +++E +EW + + G G P ++ N
Sbjct: 521 FEYIGEQKDELSFSEGEII-ILKEYVNEEWARGEVR-GRTGIFPLNFVEPVEDYPTSGAN 578
Query: 526 FPDLSLPESSQDSDNPCGAEPTAFLAQ---ALYSYTGQSAEELSFPEGALIRLLPRAQDG 582
+P ++ D+ ++ + A+ AL+S+T +++++LSF G I++L R
Sbjct: 579 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILER---- 634
Query: 583 VDDGFWRGEFGGRVGVFPSLLVEELLGPPGPPELSDPEQMLP 624
+D + RG R G+FP++ V P P E ++P
Sbjct: 635 LDSDWCRGRLQDREGIFPAVFVR-----PCPAEAKSMLAIVP 671
Score = 32.3 bits (72), Expect = 1.5
Identities = 14/61 (22%), Positives = 33/61 (54%), Gaps = 4/61 (6%)
Query: 551 AQALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGEFGGRVGVFPSLLVEELLGP 610
A L+ + + ++L+ G ++ LL + +D ++RG ++G+FP+ V+ ++
Sbjct: 441 AVVLHDFPAEQVDDLNLTSGEIVYLLEK----IDTDWYRGNCRNQIGIFPANYVKVIIDI 496
Query: 611 P 611
P
Sbjct: 497 P 497
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 55.1 bits (131), Expect = 2e-07
Identities = 40/137 (29%), Positives = 65/137 (47%), Gaps = 29/137 (21%)
Query: 479 YQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFPDLSLPESSQDS 538
+ A D+L+ G+ ++++E D+D W + R Q E G P ++
Sbjct: 649 FTAETSDDLSFKRGDRIQILERLDSD-WCRGRLQDRE-GIFPAVFVR------------- 693
Query: 539 DNPCGAEPTAFLA--------QALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRG 590
PC AE + LA +ALY + G++ +ELSF G +I L + VDD + G
Sbjct: 694 --PCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITEL----ESVDDDWMSG 747
Query: 591 EFGGRVGVFPSLLVEEL 607
E G+ G+FP ++ L
Sbjct: 748 ELMGKSGIFPKNYIQFL 764
Score = 54.7 bits (130), Expect = 3e-07
Identities = 40/134 (29%), Positives = 66/134 (49%), Gaps = 8/134 (5%)
Query: 473 AHVVFRYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFPDLSLP 532
A V+ + A + D+L +T GE + ++E+ D D W + N ++G P Y+ + +P
Sbjct: 477 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTD-WYRG-NCRNQIGIFPANYVKVI-IDIP 533
Query: 533 ESSQDSDNPCGAEPT-AFLAQALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGE 591
E + A + Y G+ +ELSF EG +I L ++ V++ + RGE
Sbjct: 534 EGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIIL----KEYVNEEWARGE 589
Query: 592 FGGRVGVFPSLLVE 605
GR G+FP VE
Sbjct: 590 VRGRTGIFPLNFVE 603
Score = 53.9 bits (128), Expect = 5e-07
Identities = 41/162 (25%), Positives = 78/162 (48%), Gaps = 25/162 (15%)
Query: 477 FRYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYL-----------N 525
F Y ++DEL+ +EGE + +++E +EW + + G G P ++ N
Sbjct: 557 FEYIGEQKDELSFSEGEII-ILKEYVNEEWARGEVR-GRTGIFPLNFVEPVEDYPTSGAN 614
Query: 526 FPDLSLPESSQDSDNPCGAEPTAFLAQ---ALYSYTGQSAEELSFPEGALIRLLPRAQDG 582
+P ++ D+ ++ + A+ AL+S+T +++++LSF G I++L R
Sbjct: 615 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILER---- 670
Query: 583 VDDGFWRGEFGGRVGVFPSLLVEELLGPPGPPELSDPEQMLP 624
+D + RG R G+FP++ V P P E ++P
Sbjct: 671 LDSDWCRGRLQDREGIFPAVFVR-----PCPAEAKSMLAIVP 707
Score = 32.3 bits (72), Expect = 1.5
Identities = 14/61 (22%), Positives = 33/61 (54%), Gaps = 4/61 (6%)
Query: 551 AQALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGEFGGRVGVFPSLLVEELLGP 610
A L+ + + ++L+ G ++ LL + +D ++RG ++G+FP+ V+ ++
Sbjct: 477 AVVLHDFPAEQVDDLNLTSGEIVYLLEK----IDTDWYRGNCRNQIGIFPANYVKVIIDI 532
Query: 611 P 611
P
Sbjct: 533 P 533
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 55.1 bits (131), Expect = 2e-07
Identities = 40/137 (29%), Positives = 65/137 (47%), Gaps = 29/137 (21%)
Query: 479 YQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFPDLSLPESSQDS 538
+ A D+L+ G+ ++++E D+D W + R Q E G P ++
Sbjct: 672 FTAETSDDLSFKRGDRIQILERLDSD-WCRGRLQDRE-GIFPAVFVR------------- 716
Query: 539 DNPCGAEPTAFLA--------QALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRG 590
PC AE + LA +ALY + G++ +ELSF G +I L + VDD + G
Sbjct: 717 --PCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITEL----ESVDDDWMSG 770
Query: 591 EFGGRVGVFPSLLVEEL 607
E G+ G+FP ++ L
Sbjct: 771 ELMGKSGIFPKNYIQFL 787
Score = 54.7 bits (130), Expect = 3e-07
Identities = 40/134 (29%), Positives = 66/134 (49%), Gaps = 8/134 (5%)
Query: 473 AHVVFRYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFPDLSLP 532
A V+ + A + D+L +T GE + ++E+ D D W + N ++G P Y+ + +P
Sbjct: 500 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTD-WYRG-NCRNQIGIFPANYVKVI-IDIP 556
Query: 533 ESSQDSDNPCGAEPT-AFLAQALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGE 591
E + A + Y G+ +ELSF EG +I L ++ V++ + RGE
Sbjct: 557 EGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIIL----KEYVNEEWARGE 612
Query: 592 FGGRVGVFPSLLVE 605
GR G+FP VE
Sbjct: 613 VRGRTGIFPLNFVE 626
Score = 53.9 bits (128), Expect = 5e-07
Identities = 41/162 (25%), Positives = 78/162 (48%), Gaps = 25/162 (15%)
Query: 477 FRYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYL-----------N 525
F Y ++DEL+ +EGE + +++E +EW + + G G P ++ N
Sbjct: 580 FEYIGEQKDELSFSEGEII-ILKEYVNEEWARGEVR-GRTGIFPLNFVEPVEDYPTSGAN 637
Query: 526 FPDLSLPESSQDSDNPCGAEPTAFLAQ---ALYSYTGQSAEELSFPEGALIRLLPRAQDG 582
+P ++ D+ ++ + A+ AL+S+T +++++LSF G I++L R
Sbjct: 638 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILER---- 693
Query: 583 VDDGFWRGEFGGRVGVFPSLLVEELLGPPGPPELSDPEQMLP 624
+D + RG R G+FP++ V P P E ++P
Sbjct: 694 LDSDWCRGRLQDREGIFPAVFVR-----PCPAEAKSMLAIVP 730
Score = 32.3 bits (72), Expect = 1.5
Identities = 14/61 (22%), Positives = 33/61 (54%), Gaps = 4/61 (6%)
Query: 551 AQALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGEFGGRVGVFPSLLVEELLGP 610
A L+ + + ++L+ G ++ LL + +D ++RG ++G+FP+ V+ ++
Sbjct: 500 AVVLHDFPAEQVDDLNLTSGEIVYLLEK----IDTDWYRGNCRNQIGIFPANYVKVIIDI 555
Query: 611 P 611
P
Sbjct: 556 P 556
>gi|239745060 PREDICTED: similar to breast cancer anti-estrogen
resistance 1 [Homo sapiens]
Length = 353
Score = 54.7 bits (130), Expect = 3e-07
Identities = 43/153 (28%), Positives = 69/153 (45%), Gaps = 15/153 (9%)
Query: 550 LAQALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGEFGGRVGVFPSLLVEELLG 609
LA+ALY +S +ELSF +G ++ +L + G+ DG+W GR G+ P ++ L+G
Sbjct: 7 LAKALYDNVAESPDELSFRKGDIMTVLEQDTQGL-DGWWLCSLHGRQGIMPGNHLKILVG 65
Query: 610 ---------PPGPPEL-SDPEQMLPSPSPPS--FSPPAPTSVLDGPPAPVLPGDKALDFP 657
PGPP + P+ L +P PP+ ++P P + P + L +
Sbjct: 66 MYDKKPAGPGPGPPATPAQPQPGLHAPVPPASQYTPMLPNTYQPQPDSVYLVPTPSKAQQ 125
Query: 658 GFLDMMAPRLRPMRPPPPPPA--KAPDPGHPDP 688
G + P + PP + P HP P
Sbjct: 126 GLYQVPGPSPQFQSPPAKQTSTFSKQTPHHPFP 158
>gi|38524622 formin binding protein 1 [Homo sapiens]
Length = 617
Score = 54.7 bits (130), Expect = 3e-07
Identities = 46/184 (25%), Positives = 83/184 (45%), Gaps = 31/184 (16%)
Query: 367 SIEQRLQEVRESIRRAQVSQVKGAARLALLQG------------AGLDVERWLKPAMTQA 414
S++ +L EV ++I + +V K A LA ++G +GL + A
Sbjct: 453 SLDHKLAEVSQNIEKLRVETQKFEAWLAEVEGRLPARSEQARRQSGLYDSQNPPTVNNCA 512
Query: 415 QDEVEQERRLSEARLSQRDLSPTAEDAELSDFEECEETGELFEEPAPQALATRALPCPAH 474
QD + +E + + ++ A D + +F++ EEP P +AL
Sbjct: 513 QDRESPDGSYTEEQSQESEMKVLATDFD-DEFDD--------EEPLPAIGTCKAL----- 558
Query: 475 VVFRYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFPDLSLPES 534
+ ++ E +++ EGE L VIEE D W + R E G+VP Y+ ++ L ++
Sbjct: 559 --YTFEGQNEGTISVVEGETLYVIEEDKGDGWTRIRRNEDEEGYVPTSYV---EVCLDKN 613
Query: 535 SQDS 538
++DS
Sbjct: 614 AKDS 617
>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
sapiens]
Length = 671
Score = 54.3 bits (129), Expect = 4e-07
Identities = 60/226 (26%), Positives = 93/226 (41%), Gaps = 23/226 (10%)
Query: 473 AHVVFRYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFPDLSLP 532
A + F +QA ELT+ +G+ + + +E D + W++ + HG +G P Y+ L
Sbjct: 385 ARLKFDFQAQSPKELTLQKGDIVYIHKEVDKN-WLEGEH-HGRLGIFPANYVEV--LPAD 440
Query: 533 ESSQDSDNPCGAEPTAFLAQALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGEF 592
E + P A A Y++ G ELSF +G I L+ + + +G G
Sbjct: 441 EIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGT- 499
Query: 593 GGRVGVFPSLLVEELLGP-----------PGPPELSDPEQMLPSPSPPS-FSPPAPTSVL 640
GR G+FP+ V+ P P P L+ + PS PS PA L
Sbjct: 500 -GRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDL 558
Query: 641 DGPPAPVLPGDKALDFPGFLDMMAPRLRPMRPPPPPPAKAPDPGHP 686
G +P G FP P+ + + P P + + P HP
Sbjct: 559 GGQTSPRRTG---FSFP--TQEPRPQTQNLGTPGPALSHSRGPSHP 599
Score = 37.7 bits (86), Expect = 0.036
Identities = 50/220 (22%), Positives = 84/220 (38%), Gaps = 13/220 (5%)
Query: 406 WLKPAMTQAQDEVEQERRLSEARLSQRDLSPTAEDAELSDFEECEETGELFEEPAPQALA 465
W + + Q E+E +R + + P+ L + E E + EL ++ +A+
Sbjct: 237 WTEESWNQFLQELETGQRPKKPLVDDPGEKPSQPIEVLLERELAELSAELDKDL--RAIE 294
Query: 466 TRALPCPAHVVFRYQAGREDELTITEGEWLEVIEE----GDADEWVKARNQHGEVGFVPE 521
TR LP P +A + W G A + G F+
Sbjct: 295 TR-LPSPKSSPAPRRAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGR 353
Query: 522 RYLNFPDLSL-PESSQDSDNPCGAEPTAFLAQAL-YSYTGQSAEELSFPEGALIRLLPRA 579
R +P + P +S +P E A L + + QS +EL+ +G ++ +
Sbjct: 354 RDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYI---- 409
Query: 580 QDGVDDGFWRGEFGGRVGVFPSLLVEELLGPPGPPELSDP 619
VD + GE GR+G+FP+ VE L P + P
Sbjct: 410 HKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPP 449
Score = 31.2 bits (69), Expect = 3.4
Identities = 14/53 (26%), Positives = 29/53 (54%)
Query: 472 PAHVVFRYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYL 524
P +++Y+ EDEL + EG+ ++V+++ D +V + + G P Y+
Sbjct: 616 PYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 668
>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
sapiens]
Length = 329
Score = 54.3 bits (129), Expect = 4e-07
Identities = 60/226 (26%), Positives = 93/226 (41%), Gaps = 23/226 (10%)
Query: 473 AHVVFRYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFPDLSLP 532
A + F +QA ELT+ +G+ + + +E D + W++ + HG +G P Y+ L
Sbjct: 43 ARLKFDFQAQSPKELTLQKGDIVYIHKEVDKN-WLEGEH-HGRLGIFPANYVEV--LPAD 98
Query: 533 ESSQDSDNPCGAEPTAFLAQALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGEF 592
E + P A A Y++ G ELSF +G I L+ + + +G G
Sbjct: 99 EIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGT- 157
Query: 593 GGRVGVFPSLLVEELLGP-----------PGPPELSDPEQMLPSPSPPS-FSPPAPTSVL 640
GR G+FP+ V+ P P P L+ + PS PS PA L
Sbjct: 158 -GRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDL 216
Query: 641 DGPPAPVLPGDKALDFPGFLDMMAPRLRPMRPPPPPPAKAPDPGHP 686
G +P G FP P+ + + P P + + P HP
Sbjct: 217 GGQTSPRRTG---FSFP--TQEPRPQTQNLGTPGPALSHSRGPSHP 257
Score = 36.6 bits (83), Expect = 0.080
Identities = 25/89 (28%), Positives = 40/89 (44%), Gaps = 5/89 (5%)
Query: 532 PESSQDSDNPCGAEPTAFLAQAL-YSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRG 590
P +S +P E A L + + QS +EL+ +G ++ + VD + G
Sbjct: 23 PSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYI----HKEVDKNWLEG 78
Query: 591 EFGGRVGVFPSLLVEELLGPPGPPELSDP 619
E GR+G+FP+ VE L P + P
Sbjct: 79 EHHGRLGIFPANYVEVLPADEIPKPIKPP 107
Score = 31.2 bits (69), Expect = 3.4
Identities = 14/53 (26%), Positives = 29/53 (54%)
Query: 472 PAHVVFRYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYL 524
P +++Y+ EDEL + EG+ ++V+++ D +V + + G P Y+
Sbjct: 274 PYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 326
>gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Homo
sapiens]
Length = 1188
Score = 53.9 bits (128), Expect = 5e-07
Identities = 38/95 (40%), Positives = 47/95 (49%), Gaps = 17/95 (17%)
Query: 609 GP-PGPPE-LSDPEQMLPSPSPPSFSPPAPTSVLDGPPAPVL-----PGDKALDFPGFLD 661
GP PGPP+ +S+P P PSPPS +PP P +L+ PP P + P +AL P L
Sbjct: 145 GPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLS 204
Query: 662 MMA----PRLRPMRP------PPPPPAKAPDPGHP 686
+ P P P PPPPP AP P P
Sbjct: 205 SPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAP 239
Score = 35.0 bits (79), Expect = 0.23
Identities = 31/98 (31%), Positives = 37/98 (37%), Gaps = 15/98 (15%)
Query: 601 SLLVEELLGPPGPPELSDPEQMLPSPSPPSFS-PPAPTSVLDGPPAPVLPGDKALDFPGF 659
S+ V+E P E + + P PPSF PA D P P PG+ P
Sbjct: 314 SIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPA- 372
Query: 660 LDMMAPRL---------RPMRPPPPPPAKAPDPGHPDP 688
+PRL R PPP PP P P P P
Sbjct: 373 ----SPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPP 406
Score = 33.9 bits (76), Expect = 0.52
Identities = 31/86 (36%), Positives = 35/86 (40%), Gaps = 14/86 (16%)
Query: 595 RVGVFPSLLVEELLGPPGPPELSDPEQMLPSPSPPSFSPPAPTSVLDGPPAPVLPGDKAL 654
R+G S E PP P L P LP P+PP PPA PP P KA
Sbjct: 375 RLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPP--LPPA------APPLPC--AQKAA 424
Query: 655 DFP-GFL---DMMAPRLRPMRPPPPP 676
P GF +P L+P PP P
Sbjct: 425 HPPAGFTKTPKSSSPALKPKPNPPSP 450
Score = 33.5 bits (75), Expect = 0.68
Identities = 25/81 (30%), Positives = 34/81 (41%), Gaps = 4/81 (4%)
Query: 610 PPGPPE--LSDPEQMLPSPSPPSFSPPAPTSVLDGPPAPVLPGDKALDFPGFLDMMAPRL 667
PP PP L+ P +P+P+PP+ + P PP V + G A R
Sbjct: 216 PPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNG-RQAEATRA 274
Query: 668 RPMRPPPPPPAKAPDPGHPDP 688
P R P P A P +P+P
Sbjct: 275 SPPRSPAEPKGSALGP-NPEP 294
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.132 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,985,847
Number of Sequences: 37866
Number of extensions: 1764333
Number of successful extensions: 21735
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 327
Number of HSP's successfully gapped in prelim test: 1014
Number of HSP's that attempted gapping in prelim test: 11820
Number of HSP's gapped (non-prelim): 7155
length of query: 690
length of database: 18,247,518
effective HSP length: 109
effective length of query: 581
effective length of database: 14,120,124
effective search space: 8203792044
effective search space used: 8203792044
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.