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Search of human proteins with 253735778
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|253735778 Rho/Rac guanine nucleotide exchange factor 2
isoform 2 [Homo sapiens]
(985 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isofor... 1933 0.0
gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isofor... 1928 0.0
gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isoofor... 1884 0.0
gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens] 585 e-167
gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens] 585 e-167
gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens] 581 e-165
gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens] 514 e-145
gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isofo... 467 e-131
gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isofor... 466 e-131
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 185 2e-46
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 185 2e-46
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo... 171 3e-42
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [... 168 3e-41
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [... 168 3e-41
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [... 168 3e-41
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 88 5e-17
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 88 5e-17
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 81 4e-15
gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens] 77 8e-14
gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens] 77 8e-14
gi|163792208 Rho guanine exchange factor 16 [Homo sapiens] 73 1e-12
gi|38373682 pleckstrin homology domain containing family G membe... 73 1e-12
gi|111154084 pleckstrin homology domain containing family G memb... 73 1e-12
gi|111154088 pleckstrin homology domain containing family G memb... 73 1e-12
gi|111154080 pleckstrin homology domain containing family G memb... 73 1e-12
gi|111154078 pleckstrin homology domain containing family G memb... 73 1e-12
gi|222080070 pleckstrin homology domain-containing family G memb... 72 3e-12
gi|222080068 pleckstrin homology domain-containing family G memb... 72 3e-12
gi|222080066 pleckstrin homology domain-containing family G memb... 72 3e-12
gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 ... 69 2e-11
>gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isoform 2
[Homo sapiens]
Length = 985
Score = 1933 bits (5007), Expect = 0.0
Identities = 985/985 (100%), Positives = 985/985 (100%)
Query: 1 MSRIESLTRARIDRSRELASKTREKEKMKEAKDARYTNGHLFTTISVSGMTMCYACNKSI 60
MSRIESLTRARIDRSRELASKTREKEKMKEAKDARYTNGHLFTTISVSGMTMCYACNKSI
Sbjct: 1 MSRIESLTRARIDRSRELASKTREKEKMKEAKDARYTNGHLFTTISVSGMTMCYACNKSI 60
Query: 61 TAKEALICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLKNNTALQSVSLRSKTTIRERP 120
TAKEALICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLKNNTALQSVSLRSKTTIRERP
Sbjct: 61 TAKEALICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLKNNTALQSVSLRSKTTIRERP 120
Query: 121 SSAIYPSDSFRQSLLGSRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRRILSQSTDSLNM 180
SSAIYPSDSFRQSLLGSRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRRILSQSTDSLNM
Sbjct: 121 SSAIYPSDSFRQSLLGSRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRRILSQSTDSLNM 180
Query: 181 RNRTLSVESLIDEEVIYSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIY 240
RNRTLSVESLIDEEVIYSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIY
Sbjct: 181 RNRTLSVESLIDEEVIYSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIY 240
Query: 241 ELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERR 300
ELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERR
Sbjct: 241 ELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERR 300
Query: 301 RQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKR 360
RQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKR
Sbjct: 301 RQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKR 360
Query: 361 FQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGL 420
FQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGL
Sbjct: 361 FQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGL 420
Query: 421 VKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGREELLRRKLIHDGCLLW 480
VKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGREELLRRKLIHDGCLLW
Sbjct: 421 VKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGREELLRRKLIHDGCLLW 480
Query: 481 KTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLDKPSVVSLQNLIVRDIANQEKGMFLI 540
KTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLDKPSVVSLQNLIVRDIANQEKGMFLI
Sbjct: 481 KTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLDKPSVVSLQNLIVRDIANQEKGMFLI 540
Query: 541 SAAPPEMYEVHTASRDDRSTWIRVIQQSVRTCPSREDFPLIETEDEAYLRRIKMELQQKD 600
SAAPPEMYEVHTASRDDRSTWIRVIQQSVRTCPSREDFPLIETEDEAYLRRIKMELQQKD
Sbjct: 541 SAAPPEMYEVHTASRDDRSTWIRVIQQSVRTCPSREDFPLIETEDEAYLRRIKMELQQKD 600
Query: 601 RALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSESLESPRGERLLQDAIRE 660
RALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSESLESPRGERLLQDAIRE
Sbjct: 601 RALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSESLESPRGERLLQDAIRE 660
Query: 661 VEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSPGVTANGEARTFNGSIELCRADSDS 720
VEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSPGVTANGEARTFNGSIELCRADSDS
Sbjct: 661 VEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSPGVTANGEARTFNGSIELCRADSDS 720
Query: 721 SQRDRNGNQLRSPQEEALQRLVNLYGLLHGLQAAVAQQDTLMEARFPEGPERREKLCRAN 780
SQRDRNGNQLRSPQEEALQRLVNLYGLLHGLQAAVAQQDTLMEARFPEGPERREKLCRAN
Sbjct: 721 SQRDRNGNQLRSPQEEALQRLVNLYGLLHGLQAAVAQQDTLMEARFPEGPERREKLCRAN 780
Query: 781 SRDGEAGRAGAAPVAPEKQATELALLQRQHALLQEELRRCRRLGEERATEAGSLEARLRE 840
SRDGEAGRAGAAPVAPEKQATELALLQRQHALLQEELRRCRRLGEERATEAGSLEARLRE
Sbjct: 781 SRDGEAGRAGAAPVAPEKQATELALLQRQHALLQEELRRCRRLGEERATEAGSLEARLRE 840
Query: 841 SEQARALLEREAEEARRQLAALGQTEPLPAEAPWARRPVDPRRRSLPAGDALYLSFNPPQ 900
SEQARALLEREAEEARRQLAALGQTEPLPAEAPWARRPVDPRRRSLPAGDALYLSFNPPQ
Sbjct: 841 SEQARALLEREAEEARRQLAALGQTEPLPAEAPWARRPVDPRRRSLPAGDALYLSFNPPQ 900
Query: 901 PSRGTDRLDLPVTTRSVHRNFEDRERQELGSPEERLQDSSDPDTGSEEEGSSRLSPPHSP 960
PSRGTDRLDLPVTTRSVHRNFEDRERQELGSPEERLQDSSDPDTGSEEEGSSRLSPPHSP
Sbjct: 901 PSRGTDRLDLPVTTRSVHRNFEDRERQELGSPEERLQDSSDPDTGSEEEGSSRLSPPHSP 960
Query: 961 RDFTRMQDIPEETESRDGEAVASES 985
RDFTRMQDIPEETESRDGEAVASES
Sbjct: 961 RDFTRMQDIPEETESRDGEAVASES 985
>gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isoform 1
[Homo sapiens]
Length = 986
Score = 1928 bits (4995), Expect = 0.0
Identities = 985/986 (99%), Positives = 985/986 (99%), Gaps = 1/986 (0%)
Query: 1 MSRIESLTRARIDRSRELASKTREKEKMKEAKDARYTNGHLFTTISVSGMTMCYACNKSI 60
MSRIESLTRARIDRSRELASKTREKEKMKEAKDARYTNGHLFTTISVSGMTMCYACNKSI
Sbjct: 1 MSRIESLTRARIDRSRELASKTREKEKMKEAKDARYTNGHLFTTISVSGMTMCYACNKSI 60
Query: 61 TAKEALICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLKNNTALQSVSLRSKTTIRERP 120
TAKEALICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLKNNTALQSVSLRSKTTIRERP
Sbjct: 61 TAKEALICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLKNNTALQSVSLRSKTTIRERP 120
Query: 121 SSAIYPSDSFRQSLLGSRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRRILSQSTDSLNM 180
SSAIYPSDSFRQSLLGSRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRRILSQSTDSLNM
Sbjct: 121 SSAIYPSDSFRQSLLGSRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRRILSQSTDSLNM 180
Query: 181 RNRTLSVESLIDE-EVIYSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVI 239
RNRTLSVESLIDE EVIYSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVI
Sbjct: 181 RNRTLSVESLIDEAEVIYSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVI 240
Query: 240 YELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLER 299
YELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLER
Sbjct: 241 YELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLER 300
Query: 300 RRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDK 359
RRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDK
Sbjct: 301 RRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDK 360
Query: 360 RFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTALG 419
RFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTALG
Sbjct: 361 RFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTALG 420
Query: 420 LVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGREELLRRKLIHDGCLL 479
LVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGREELLRRKLIHDGCLL
Sbjct: 421 LVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGREELLRRKLIHDGCLL 480
Query: 480 WKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLDKPSVVSLQNLIVRDIANQEKGMFL 539
WKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLDKPSVVSLQNLIVRDIANQEKGMFL
Sbjct: 481 WKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLDKPSVVSLQNLIVRDIANQEKGMFL 540
Query: 540 ISAAPPEMYEVHTASRDDRSTWIRVIQQSVRTCPSREDFPLIETEDEAYLRRIKMELQQK 599
ISAAPPEMYEVHTASRDDRSTWIRVIQQSVRTCPSREDFPLIETEDEAYLRRIKMELQQK
Sbjct: 541 ISAAPPEMYEVHTASRDDRSTWIRVIQQSVRTCPSREDFPLIETEDEAYLRRIKMELQQK 600
Query: 600 DRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSESLESPRGERLLQDAIR 659
DRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSESLESPRGERLLQDAIR
Sbjct: 601 DRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSESLESPRGERLLQDAIR 660
Query: 660 EVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSPGVTANGEARTFNGSIELCRADSD 719
EVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSPGVTANGEARTFNGSIELCRADSD
Sbjct: 661 EVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSPGVTANGEARTFNGSIELCRADSD 720
Query: 720 SSQRDRNGNQLRSPQEEALQRLVNLYGLLHGLQAAVAQQDTLMEARFPEGPERREKLCRA 779
SSQRDRNGNQLRSPQEEALQRLVNLYGLLHGLQAAVAQQDTLMEARFPEGPERREKLCRA
Sbjct: 721 SSQRDRNGNQLRSPQEEALQRLVNLYGLLHGLQAAVAQQDTLMEARFPEGPERREKLCRA 780
Query: 780 NSRDGEAGRAGAAPVAPEKQATELALLQRQHALLQEELRRCRRLGEERATEAGSLEARLR 839
NSRDGEAGRAGAAPVAPEKQATELALLQRQHALLQEELRRCRRLGEERATEAGSLEARLR
Sbjct: 781 NSRDGEAGRAGAAPVAPEKQATELALLQRQHALLQEELRRCRRLGEERATEAGSLEARLR 840
Query: 840 ESEQARALLEREAEEARRQLAALGQTEPLPAEAPWARRPVDPRRRSLPAGDALYLSFNPP 899
ESEQARALLEREAEEARRQLAALGQTEPLPAEAPWARRPVDPRRRSLPAGDALYLSFNPP
Sbjct: 841 ESEQARALLEREAEEARRQLAALGQTEPLPAEAPWARRPVDPRRRSLPAGDALYLSFNPP 900
Query: 900 QPSRGTDRLDLPVTTRSVHRNFEDRERQELGSPEERLQDSSDPDTGSEEEGSSRLSPPHS 959
QPSRGTDRLDLPVTTRSVHRNFEDRERQELGSPEERLQDSSDPDTGSEEEGSSRLSPPHS
Sbjct: 901 QPSRGTDRLDLPVTTRSVHRNFEDRERQELGSPEERLQDSSDPDTGSEEEGSSRLSPPHS 960
Query: 960 PRDFTRMQDIPEETESRDGEAVASES 985
PRDFTRMQDIPEETESRDGEAVASES
Sbjct: 961 PRDFTRMQDIPEETESRDGEAVASES 986
>gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isooform 3
[Homo sapiens]
Length = 958
Score = 1884 bits (4881), Expect = 0.0
Identities = 958/958 (100%), Positives = 958/958 (100%)
Query: 28 MKEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCT 87
MKEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCT
Sbjct: 1 MKEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCT 60
Query: 88 KVKQKQQKAALLKNNTALQSVSLRSKTTIRERPSSAIYPSDSFRQSLLGSRRGRSSLSLA 147
KVKQKQQKAALLKNNTALQSVSLRSKTTIRERPSSAIYPSDSFRQSLLGSRRGRSSLSLA
Sbjct: 61 KVKQKQQKAALLKNNTALQSVSLRSKTTIRERPSSAIYPSDSFRQSLLGSRRGRSSLSLA 120
Query: 148 KSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEEVIYSELMSDFEMD 207
KSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEEVIYSELMSDFEMD
Sbjct: 121 KSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEEVIYSELMSDFEMD 180
Query: 208 EKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEE 267
EKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEE
Sbjct: 181 EKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEE 240
Query: 268 LHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSG 327
LHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSG
Sbjct: 241 LHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSG 300
Query: 328 PSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVT 387
PSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVT
Sbjct: 301 PSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVT 360
Query: 388 QRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNR 447
QRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNR
Sbjct: 361 QRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNR 420
Query: 448 MDPRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQ 507
MDPRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQ
Sbjct: 421 MDPRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQ 480
Query: 508 KYIFPTLDKPSVVSLQNLIVRDIANQEKGMFLISAAPPEMYEVHTASRDDRSTWIRVIQQ 567
KYIFPTLDKPSVVSLQNLIVRDIANQEKGMFLISAAPPEMYEVHTASRDDRSTWIRVIQQ
Sbjct: 481 KYIFPTLDKPSVVSLQNLIVRDIANQEKGMFLISAAPPEMYEVHTASRDDRSTWIRVIQQ 540
Query: 568 SVRTCPSREDFPLIETEDEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGG 627
SVRTCPSREDFPLIETEDEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGG
Sbjct: 541 SVRTCPSREDFPLIETEDEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGG 600
Query: 628 SGMALPTLPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLE 687
SGMALPTLPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLE
Sbjct: 601 SGMALPTLPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLE 660
Query: 688 PDSGGNTSPGVTANGEARTFNGSIELCRADSDSSQRDRNGNQLRSPQEEALQRLVNLYGL 747
PDSGGNTSPGVTANGEARTFNGSIELCRADSDSSQRDRNGNQLRSPQEEALQRLVNLYGL
Sbjct: 661 PDSGGNTSPGVTANGEARTFNGSIELCRADSDSSQRDRNGNQLRSPQEEALQRLVNLYGL 720
Query: 748 LHGLQAAVAQQDTLMEARFPEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALLQ 807
LHGLQAAVAQQDTLMEARFPEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALLQ
Sbjct: 721 LHGLQAAVAQQDTLMEARFPEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALLQ 780
Query: 808 RQHALLQEELRRCRRLGEERATEAGSLEARLRESEQARALLEREAEEARRQLAALGQTEP 867
RQHALLQEELRRCRRLGEERATEAGSLEARLRESEQARALLEREAEEARRQLAALGQTEP
Sbjct: 781 RQHALLQEELRRCRRLGEERATEAGSLEARLRESEQARALLEREAEEARRQLAALGQTEP 840
Query: 868 LPAEAPWARRPVDPRRRSLPAGDALYLSFNPPQPSRGTDRLDLPVTTRSVHRNFEDRERQ 927
LPAEAPWARRPVDPRRRSLPAGDALYLSFNPPQPSRGTDRLDLPVTTRSVHRNFEDRERQ
Sbjct: 841 LPAEAPWARRPVDPRRRSLPAGDALYLSFNPPQPSRGTDRLDLPVTTRSVHRNFEDRERQ 900
Query: 928 ELGSPEERLQDSSDPDTGSEEEGSSRLSPPHSPRDFTRMQDIPEETESRDGEAVASES 985
ELGSPEERLQDSSDPDTGSEEEGSSRLSPPHSPRDFTRMQDIPEETESRDGEAVASES
Sbjct: 901 ELGSPEERLQDSSDPDTGSEEEGSSRLSPPHSPRDFTRMQDIPEETESRDGEAVASES 958
>gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]
Length = 2817
Score = 585 bits (1507), Expect = e-167
Identities = 371/908 (40%), Positives = 550/908 (60%), Gaps = 59/908 (6%)
Query: 1 MSRIESLTRARIDRSRELASKTREKEKMKEA--------KDARYTNGHLFTTISVSGMTM 52
+SR S + ++ S++ K +EK+K+KE KD + NGH F++I V G
Sbjct: 1749 VSRTFSYIKNKMSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPIS 1808
Query: 53 CYACNKSITAKEALICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLKNNTA-LQSVSLR 111
C C K T K+A C C+ +H C+++LA+C KVK KQ K +L ++T+ L +V +R
Sbjct: 1809 CSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMR 1868
Query: 112 SKTTI-RERPSSAIYPSDSFRQS-LLGSRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRR 169
+K + +ERP SA+ D + + +RR + S+SL+KSVS NI G NDE+ +
Sbjct: 1869 NKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWK 1928
Query: 170 ILSQSTDSLNMRNRTL-SVESLIDE----EVIYSELMSDFEMDEKDFAADSWSLAVDSSF 224
LS STDSLN ++ S ESL DE ++ +L+ DFE++ K A+SWS +DS F
Sbjct: 1929 FLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKF 1988
Query: 225 LQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDE 284
L+Q KK+V+K+Q+VIYEL+QTE HHVRTLKIM+ ++ GM+ +L E +V+ LFPC+DE
Sbjct: 1989 LKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDE 2048
Query: 285 LSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRH 344
L IH++F ++LER++++L S +NF+I R+GD+L++QFSG +AE++ KTY +FC +H
Sbjct: 2049 LISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQH 2108
Query: 345 SKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHS 404
++++ +K+LYA+DKRFQ F++K +V++R G+ ECILLVTQRITKYP+L RILQ +
Sbjct: 2109 NQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCT 2168
Query: 405 HGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGR 464
E E++DL +L LVK+++ VD + EK RL EIY + D ++ + F +
Sbjct: 2169 KDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAK 2228
Query: 465 EELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLD-KPSVVSLQ 523
E+L R+KL+ DG + K A GR K+V +L+TD+LVFLQEKDQKYIF +LD K +V+SL+
Sbjct: 2229 EDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLK 2288
Query: 524 NLIVRDIANQEKGMFLIS--AAPPEMYEVHTASRDDRSTWIRVIQQSVRTCPSREDFPL- 580
LIVR++A++EKG+FLIS PEM EVH +S+++R++WI++IQ ++ T ED +
Sbjct: 2289 KLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIP 2348
Query: 581 IETEDEAYL-----RRIKMELQQKDRALVELLREKVGLFAEMTHFQA--EEDGGSGMALP 633
E E+E + R +K +L QKD+ ++ LL EK +F +M ED P
Sbjct: 2349 SENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPED-----CSP 2403
Query: 634 T-LPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGP-GVELLLTPREP--------- 682
T PR LFRS + E+ +G L++ AI EVE L+ L+ G G L T P
Sbjct: 2404 THSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPV 2463
Query: 683 ALPLEPDS-GGNTSPGVTAN--GEARTFNGSIELCRADSDSSQRDRNGN-----QLRSPQ 734
+LP ++ GG S + A+ GE + +L R +SDS + + GN L+
Sbjct: 2464 SLPRRAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTESDSGLK-KGGNANLVFMLKRNS 2522
Query: 735 EEALQRLVNLYGLLHGLQAAVAQQDTLMEARFPEGPERREKLCRANSRDGEAGRAGAAPV 794
E+ +Q +V+LY LL LQ V QQD+ +E + ER L R+ SR
Sbjct: 2523 EQVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSER--ALTRSLSRPSSLIEQ-EKQR 2579
Query: 795 APEKQATELALLQRQHALLQEELRRCRRLGEERATEAGSLEA----RLRESEQARALLER 850
+ EKQ +LA LQ+Q A EE RR R E R E EA R E +Q + LE+
Sbjct: 2580 SLEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEK 2639
Query: 851 EAEEARRQ 858
E EE +++
Sbjct: 2640 EREELQQK 2647
>gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]
Length = 2813
Score = 585 bits (1507), Expect = e-167
Identities = 371/908 (40%), Positives = 550/908 (60%), Gaps = 59/908 (6%)
Query: 1 MSRIESLTRARIDRSRELASKTREKEKMKEA--------KDARYTNGHLFTTISVSGMTM 52
+SR S + ++ S++ K +EK+K+KE KD + NGH F++I V G
Sbjct: 1745 VSRTFSYIKNKMSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPIS 1804
Query: 53 CYACNKSITAKEALICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLKNNTA-LQSVSLR 111
C C K T K+A C C+ +H C+++LA+C KVK KQ K +L ++T+ L +V +R
Sbjct: 1805 CSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMR 1864
Query: 112 SKTTI-RERPSSAIYPSDSFRQS-LLGSRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRR 169
+K + +ERP SA+ D + + +RR + S+SL+KSVS NI G NDE+ +
Sbjct: 1865 NKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWK 1924
Query: 170 ILSQSTDSLNMRNRTL-SVESLIDE----EVIYSELMSDFEMDEKDFAADSWSLAVDSSF 224
LS STDSLN ++ S ESL DE ++ +L+ DFE++ K A+SWS +DS F
Sbjct: 1925 FLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKF 1984
Query: 225 LQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDE 284
L+Q KK+V+K+Q+VIYEL+QTE HHVRTLKIM+ ++ GM+ +L E +V+ LFPC+DE
Sbjct: 1985 LKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDE 2044
Query: 285 LSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRH 344
L IH++F ++LER++++L S +NF+I R+GD+L++QFSG +AE++ KTY +FC +H
Sbjct: 2045 LISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQH 2104
Query: 345 SKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHS 404
++++ +K+LYA+DKRFQ F++K +V++R G+ ECILLVTQRITKYP+L RILQ +
Sbjct: 2105 NQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCT 2164
Query: 405 HGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGR 464
E E++DL +L LVK+++ VD + EK RL EIY + D ++ + F +
Sbjct: 2165 KDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAK 2224
Query: 465 EELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLD-KPSVVSLQ 523
E+L R+KL+ DG + K A GR K+V +L+TD+LVFLQEKDQKYIF +LD K +V+SL+
Sbjct: 2225 EDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLK 2284
Query: 524 NLIVRDIANQEKGMFLIS--AAPPEMYEVHTASRDDRSTWIRVIQQSVRTCPSREDFPL- 580
LIVR++A++EKG+FLIS PEM EVH +S+++R++WI++IQ ++ T ED +
Sbjct: 2285 KLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIP 2344
Query: 581 IETEDEAYL-----RRIKMELQQKDRALVELLREKVGLFAEMTHFQA--EEDGGSGMALP 633
E E+E + R +K +L QKD+ ++ LL EK +F +M ED P
Sbjct: 2345 SENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPED-----CSP 2399
Query: 634 T-LPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGP-GVELLLTPREP--------- 682
T PR LFRS + E+ +G L++ AI EVE L+ L+ G G L T P
Sbjct: 2400 THSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPV 2459
Query: 683 ALPLEPDS-GGNTSPGVTAN--GEARTFNGSIELCRADSDSSQRDRNGN-----QLRSPQ 734
+LP ++ GG S + A+ GE + +L R +SDS + + GN L+
Sbjct: 2460 SLPRRAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTESDSGLK-KGGNANLVFMLKRNS 2518
Query: 735 EEALQRLVNLYGLLHGLQAAVAQQDTLMEARFPEGPERREKLCRANSRDGEAGRAGAAPV 794
E+ +Q +V+LY LL LQ V QQD+ +E + ER L R+ SR
Sbjct: 2519 EQVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSER--ALTRSLSRPSSLIEQ-EKQR 2575
Query: 795 APEKQATELALLQRQHALLQEELRRCRRLGEERATEAGSLEA----RLRESEQARALLER 850
+ EKQ +LA LQ+Q A EE RR R E R E EA R E +Q + LE+
Sbjct: 2576 SLEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEK 2635
Query: 851 EAEEARRQ 858
E EE +++
Sbjct: 2636 EREELQQK 2643
>gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]
Length = 1058
Score = 581 bits (1497), Expect = e-165
Identities = 368/894 (41%), Positives = 543/894 (60%), Gaps = 59/894 (6%)
Query: 15 SRELASKTREKEKMKEA--------KDARYTNGHLFTTISVSGMTMCYACNKSITAKEAL 66
S++ K +EK+K+KE KD + NGH F++I V G C C K T K+A
Sbjct: 4 SKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNKDAY 63
Query: 67 ICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLKNNTA-LQSVSLRSKTTI-RERPSSAI 124
C C+ +H C+++LA+C KVK KQ K +L ++T+ L +V +R+K + +ERP SA+
Sbjct: 64 TCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPSQPKERPRSAV 123
Query: 125 YPSDSFRQS-LLGSRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNR 183
D + + +RR + S+SL+KSVS NI G NDE+ + LS STDSLN ++
Sbjct: 124 LLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNKISK 183
Query: 184 TL-SVESLIDE----EVIYSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDV 238
S ESL DE ++ +L+ DFE++ K A+SWS +DS FL+Q KK+V+K+Q+V
Sbjct: 184 VNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKKDVVKRQEV 243
Query: 239 IYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLE 298
IYEL+QTE HHVRTLKIM+ ++ GM+ +L E +V+ LFPC+DEL IH++F ++LE
Sbjct: 244 IYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQRILE 303
Query: 299 RRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARD 358
R++++L S +NF+I R+GD+L++QFSG +AE++ KTY +FC +H++++ +K+LYA+D
Sbjct: 304 RKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKD 363
Query: 359 KRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTAL 418
KRFQ F++K +V++R G+ ECILLVTQRITKYP+L RILQ + E E++DL +L
Sbjct: 364 KRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSL 423
Query: 419 GLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGREELLRRKLIHDGCL 478
LVK+++ VD + EK RL EIY + D ++ + F +E+L R+KL+ DG +
Sbjct: 424 SLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRDGSV 483
Query: 479 LWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLD-KPSVVSLQNLIVRDIANQEKGM 537
K A GR K+V +L+TD+LVFLQEKDQKYIF +LD K +V+SL+ LIVR++A++EKG+
Sbjct: 484 FLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHEEKGL 543
Query: 538 FLIS--AAPPEMYEVHTASRDDRSTWIRVIQQSVRTCPSREDFPL-IETEDEAYL----- 589
FLIS PEM EVH +S+++R++WI++IQ ++ T ED + E E+E +
Sbjct: 544 FLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPSENEEEKKMLDTRA 603
Query: 590 RRIKMELQQKDRALVELLREKVGLFAEMTHFQA--EEDGGSGMALPT-LPRGLFRSESLE 646
R +K +L QKD+ ++ LL EK +F +M ED PT PR LFRS + E
Sbjct: 604 RELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPED-----CSPTHSPRVLFRSNTEE 658
Query: 647 SPRGERLLQDAIREVEGLKDLLVGP-GVELLLTPREP---------ALPLEPDS-GGNTS 695
+ +G L++ AI EVE L+ L+ G G L T P +LP ++ GG S
Sbjct: 659 ALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFDS 718
Query: 696 PGVTAN--GEARTFNGSIELCRADSDSSQRDRNGN-----QLRSPQEEALQRLVNLYGLL 748
+ A+ GE + +L R +SDS + + GN L+ E+ +Q +V+LY LL
Sbjct: 719 HQMNASKGGEKEEGDDGQDLRRTESDSGLK-KGGNANLVFMLKRNSEQVVQSVVHLYELL 777
Query: 749 HGLQAAVAQQDTLMEARFPEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALLQR 808
LQ V QQD+ +E + ER L R+ SR + EKQ +LA LQ+
Sbjct: 778 SALQGVVLQQDSYIEDQKLVLSER--ALTRSLSRPSSLIEQ-EKQRSLEKQRQDLANLQK 834
Query: 809 QHALLQEELRRCRRLGEERATEAGSLEA----RLRESEQARALLEREAEEARRQ 858
Q A EE RR R E R E EA R E +Q + LE+E EE +++
Sbjct: 835 QQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQK 888
>gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens]
Length = 1651
Score = 514 bits (1325), Expect = e-145
Identities = 334/890 (37%), Positives = 489/890 (54%), Gaps = 65/890 (7%)
Query: 15 SRELASKTREKEKMKEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVT 74
+R + + + K K K+AKD N H F + SG+ C C+K++ KE+L C CN
Sbjct: 628 NRMTSPRNKSKTKSKDAKDKEKLNRHQFAPGTFSGVLQCLVCDKTLLGKESLQCSNCNAN 687
Query: 75 IHNRCKDTLANCTKVKQKQQKAALLKNNTALQSVSLRSKTTIRERPSSAIYPSDSFRQSL 134
+H CKD CTK + Q+K K T L + S R +P +++PS S L
Sbjct: 688 VHKGCKDAAPACTK--KFQEKYNKNKPQTILGNSSFRDIP----QPGLSLHPSSSVPVGL 741
Query: 135 LGSRRGRSSL--SLAKSVSTTNI------AGHFNDESPLGLRRILSQSTDSLNMRNRTLS 186
RR L++SV T + A ES R S S + L + S
Sbjct: 742 PTGRRETVGQVHPLSRSVPGTTLESFRRSATSLESESDHNSCRSRSHSDELLQSMGSSPS 801
Query: 187 VESLIDEEVIYSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTE 246
ES I E+V+ S L SD D ++F A+SWSL VD SF + +K+V+K+QDVI+EL+QTE
Sbjct: 802 TESFIMEDVVDSSLWSDLSSDAQEFEAESWSLVVDPSFCNRQEKDVIKRQDVIFELMQTE 861
Query: 247 LHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCP 306
+HH++TL IM+ +FR GM EEL L+ V +FPC+DEL +IH F + ERR+++ C
Sbjct: 862 MHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKERRQES-CA 920
Query: 307 GSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIR 366
GS RNFVI R+GD+L+ QFS +A +M K Y EFC H +A+ L+KEL ++K+FQ FI+
Sbjct: 921 GSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKEL-QQNKKFQNFIK 979
Query: 367 KVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLS 426
+ +R G+ ECILLVTQRITKYP+L+ RILQ++ EE +DL AL L+K++++
Sbjct: 980 LRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLIKDMIA 1039
Query: 427 NVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGREELL--RRKLIHDGCLLWKTAT 484
VD + + EK + EI N+++ + T + F ++ L+ R L++DG + WKTAT
Sbjct: 1040 TVDLKVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQALMSEERTLLYDGLVYWKTAT 1099
Query: 485 GRFKDVLVLLMTDVLVFLQEKDQKYIFPTLD-KPSVVSLQNLIVRDIANQEKGMFLISA- 542
GRFKD+L LL+TDVL+FLQEKDQKYIF +D KPSV+SLQ LI R++AN+E+GMFLISA
Sbjct: 1100 GRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPSVISLQKLIAREVANEERGMFLISAS 1159
Query: 543 -APPEMYEVHTASRDDRSTWIRVIQQSVRTCPSREDFPLIETEDE--------AYLRRIK 593
A PEMYE+HT S+++R+ W+R IQQ+V +CP + E++++ A +++ +
Sbjct: 1160 SAGPEMYEIHTNSKEERNNWMRRIQQAVESCPEEKGGRTSESDEDKRKAEARVAKIQQCQ 1219
Query: 594 MELQQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSESLESPRGERL 653
L +D+ + L EK+ ++AE+ ED + P L + + E P+ L
Sbjct: 1220 EILTNQDQQICAYLEEKLHIYAELGELSGFED------VHLEPHLLIKPDPGEPPQAASL 1273
Query: 654 LQDAIREVEGLKDLLVGPGVELLLTPREPA---------LPLEPDSGGNTSPGVTANGEA 704
L A++E E L+ + + + E + L G T+ VT E
Sbjct: 1274 LAAALKEAESLQVAVKASQMGAVSQSCEDSCGDSVLADTLSSHDVPGSPTASLVTGGREG 1333
Query: 705 RTFNG------SIELCRADSDSSQRDRNGNQLRSPQEEALQRLVNLYGLLHGLQAAVAQQ 758
R + + A SD+ ++ N S Q E +Q + NL LL+ LQAA+ Q
Sbjct: 1334 RGCSDVDPGIQGVVTDLAVSDAGEKVECRNFPGSSQSEIIQAIQNLTRLLYSLQAALTIQ 1393
Query: 759 DTLME-----ARFPEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELA-LLQRQHAL 812
D+ +E + EG + R + R ++Q ELA + Q QH L
Sbjct: 1394 DSHIEIHRLVLQQQEGLSLGHSILRGGPLQDQKSRDA------DRQHEELANVHQLQHQL 1447
Query: 813 LQEE---LRRCRRLGEERATEAGSLEARLRESEQARALLEREAEEARRQL 859
QE+ LRRC + +AT L+ R RE + LL R E QL
Sbjct: 1448 QQEQRRWLRRCEQQQRAQATRESWLQERERECQSQEELLLRSRGELDLQL 1497
>gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isoform
b [Homo sapiens]
Length = 1173
Score = 467 bits (1201), Expect = e-131
Identities = 306/823 (37%), Positives = 459/823 (55%), Gaps = 79/823 (9%)
Query: 99 LKNNTALQSVSLRSKTTIRERPSSAIYPSDSFRQSLLGSRRGRSSLSLAKSVSTTN---I 155
L N+ L SV+ K R S P+ S + S++G + + + T I
Sbjct: 124 LSTNSVLASVTASLKEHPRGTLLSDGSPALSRNVGMTVSQKGGPQPTPSPAGPGTQLGPI 183
Query: 156 AGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEEVIYSELMSDFEMDEKDFAADS 215
G DE+ + + DSL++ + + ES+ E+ + L S+ E D +F A+S
Sbjct: 184 TGEM-DEADSAFLKFKQTADDSLSLTSP--NTESIFVEDPYTASLRSEIESDGHEFEAES 240
Query: 216 WSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVV 275
WSLAVD+++ ++ K+EV+K+QDV+YEL+QTE+HHVRTLKIM +++ + EEL +
Sbjct: 241 WSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAI 300
Query: 276 QGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCK 335
LFPC D+L + H+ FL++L ERR+++L GS RN+VI ++GDLL+ QFSG + E+M +
Sbjct: 301 GRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKE 360
Query: 336 TYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPL 395
Y FCS H++A+ YK L ++K+FQ I+K+ ++++R GVQECILLVTQRITKYP+
Sbjct: 361 KYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPV 420
Query: 396 LISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTP 455
L+ RI+Q++ E+ +DLT AL L+K+++S VD + + EKG RL+EI +MD ++ +
Sbjct: 421 LVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSK 480
Query: 456 VPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLD 515
+ F +E++L+R+L +G L WKT +GR KD+L +L+TDVL+ LQEKDQKY+F ++D
Sbjct: 481 LKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVD 540
Query: 516 -KPSVVSLQNLIVRDIANQEKGMFLISAA--PPEMYEVHTASRDDRSTWIRVIQQSVRTC 572
KP V+SLQ LIVR++AN+EK MFLISA+ PEMYE++T+S++DR+ W+ IQ++V +C
Sbjct: 541 SKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESC 600
Query: 573 PSREDFPLIETEDE--------AYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEE 624
P E+ P E+E LR + L KD+ + + L EK ++ EM E
Sbjct: 601 PDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGLE 660
Query: 625 DGGSGMALPTLPRGLFR-SESLESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPA 683
D LP PRGLFR + E+ +GE +L+ A+ E+EG++ L+ A
Sbjct: 661 D------LPQ-PRGLFRGGDPSETLQGELILKSAMSEIEGIQ--------SLICRQLGSA 705
Query: 684 LPLEPDSGGNTSPGVTAN-------GEARTFNGSIELCRADSDSSQRDRN---------- 726
D G +T P A + T NGS + + +D RD
Sbjct: 706 NGQAEDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKL 765
Query: 727 ------GNQLRSPQ------------------EEALQRLVNLYGLLHGLQAAVAQQDTLM 762
G+ SPQ E +QR+ L LL LQA +A QD+ +
Sbjct: 766 SDSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYV 825
Query: 763 EARFPEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALLQRQHALLQEELRRCRR 822
E + + REK R S G EKQ E A L++ + L+ E +R R
Sbjct: 826 ETQ-RAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWER 884
Query: 823 LGEERATEAGSLEARLRESE----QARALLEREAEEARRQLAA 861
+ + E ARL+E E Q R LE+E E RQ A
Sbjct: 885 ERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQA 927
>gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isoform a
[Homo sapiens]
Length = 1015
Score = 466 bits (1200), Expect = e-131
Identities = 291/758 (38%), Positives = 435/758 (57%), Gaps = 75/758 (9%)
Query: 161 DESPLGLRRILSQSTDSLNMRNRTLSVESLIDEEVIYSELMSDFEMDEKDFAADSWSLAV 220
DE+ + + DSL++ + + ES+ E+ + L S+ E D +F A+SWSLAV
Sbjct: 30 DEADSAFLKFKQTADDSLSLTSP--NTESIFVEDPYTASLRSEIESDGHEFEAESWSLAV 87
Query: 221 DSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFP 280
D+++ ++ K+EV+K+QDV+YEL+QTE+HHVRTLKIM +++ + EEL + LFP
Sbjct: 88 DAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFP 147
Query: 281 CVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEF 340
C D+L + H+ FL++L ERR+++L GS RN+VI ++GDLL+ QFSG + E+M + Y F
Sbjct: 148 CADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVF 207
Query: 341 CSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRI 400
CS H++A+ YK L ++K+FQ I+K+ ++++R GVQECILLVTQRITKYP+L+ RI
Sbjct: 208 CSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERI 267
Query: 401 LQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKG 460
+Q++ E+ +DLT AL L+K+++S VD + + EKG RL+EI +MD ++ + +
Sbjct: 268 IQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSKLKNGL 327
Query: 461 PFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLD-KPSV 519
F +E++L+R+L +G L WKT +GR KD+L +L+TDVL+ LQEKDQKY+F ++D KP V
Sbjct: 328 TFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVDSKPPV 387
Query: 520 VSLQNLIVRDIANQEKGMFLISAA--PPEMYEVHTASRDDRSTWIRVIQQSVRTCPSRED 577
+SLQ LIVR++AN+EK MFLISA+ PEMYE++T+S++DR+ W+ IQ++V +CP E+
Sbjct: 388 ISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESCPDEEE 447
Query: 578 FPLIETEDE--------AYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGGSG 629
P E+E LR + L KD+ + + L EK ++ EM ED
Sbjct: 448 GPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGLED---- 503
Query: 630 MALPTLPRGLFR-SESLESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEP 688
LP PRGLFR + E+ +GE +L+ A+ E+EG++ L+ A
Sbjct: 504 --LPQ-PRGLFRGGDPSETLQGELILKSAMSEIEGIQ--------SLICRQLGSANGQAE 552
Query: 689 DSGGNTSPGVTAN-------GEARTFNGSIELCRADSDSSQRDRN--------------- 726
D G +T P A + T NGS + + +D RD
Sbjct: 553 DGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKLSDSDI 612
Query: 727 -GNQLRSPQ------------------EEALQRLVNLYGLLHGLQAAVAQQDTLMEARFP 767
G+ SPQ E +QR+ L LL LQA +A QD+ +E +
Sbjct: 613 PGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVETQ-R 671
Query: 768 EGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALLQRQHALLQEELRRCRRLGEER 827
+ REK R S G EKQ E A L++ + L+ E +R R + +
Sbjct: 672 AAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWERERQWQ 731
Query: 828 ATEAGSLEARLRESE----QARALLEREAEEARRQLAA 861
E ARL+E E Q R LE+E E RQ A
Sbjct: 732 HQELERAGARLQEREGEARQLRERLEQERAELERQRQA 769
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
[Homo sapiens]
Length = 1562
Score = 185 bits (470), Expect = 2e-46
Identities = 128/453 (28%), Positives = 231/453 (50%), Gaps = 38/453 (8%)
Query: 137 SRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEEVI 196
+R +S+ S S+ST ++ +P RR S + SL TL L D+
Sbjct: 686 TRLHQSASSSTSSLSTRSLENPTPPFTPKMGRR--SIESPSLGFCTDTLLPHLLEDDLGQ 743
Query: 197 YSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIM 256
S+L E + A +W V + + + +Q+VI EL TE H+RTL+++
Sbjct: 744 LSDL-------EPEPDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVL 796
Query: 257 TRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHR 316
+F M +E + + LFP + EL +IH + + + R + +I
Sbjct: 797 DLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLREEGP--------IIKE 848
Query: 317 LGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKR 376
+ DL++++F GP+ E++ + ++FCS S AL+L K ++ RFQ F+++ +R
Sbjct: 849 ISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRR 908
Query: 377 HGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLE 436
+++ I+ QR+TKYPLL+ I++H+ G E + L A +E+L V+E + Q E
Sbjct: 909 LQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTE 968
Query: 437 KGARLQEIYNRMD----PRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLV 492
RL+ R+D RA P+ + F +L RK+IH+G L W+ + + D+ V
Sbjct: 969 NRHRLEGYQKRLDATALERASNPLAAE--FKSLDLTTRKMIHEGPLTWRISKDKTLDLHV 1026
Query: 493 LLMTDVLVFLQEKDQKYIFPTLDKPS------------VVSLQNLIVRDIANQEKGMFLI 540
LL+ D+LV LQ++D+K + K + V+ L +++R +A ++ F+I
Sbjct: 1027 LLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFII 1086
Query: 541 SAA---PPEMYEVHTASRDDRSTWIRVIQQSVR 570
+ PP++YE+ + D++TW+ +++++VR
Sbjct: 1087 CTSKLGPPQIYELVALTSSDKNTWMELLEEAVR 1119
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
[Homo sapiens]
Length = 1522
Score = 185 bits (470), Expect = 2e-46
Identities = 128/453 (28%), Positives = 231/453 (50%), Gaps = 38/453 (8%)
Query: 137 SRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEEVI 196
+R +S+ S S+ST ++ +P RR S + SL TL L D+
Sbjct: 646 TRLHQSASSSTSSLSTRSLENPTPPFTPKMGRR--SIESPSLGFCTDTLLPHLLEDDLGQ 703
Query: 197 YSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIM 256
S+L E + A +W V + + + +Q+VI EL TE H+RTL+++
Sbjct: 704 LSDL-------EPEPDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVL 756
Query: 257 TRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHR 316
+F M +E + + LFP + EL +IH + + + R + +I
Sbjct: 757 DLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLREEGP--------IIKE 808
Query: 317 LGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKR 376
+ DL++++F GP+ E++ + ++FCS S AL+L K ++ RFQ F+++ +R
Sbjct: 809 ISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRR 868
Query: 377 HGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLE 436
+++ I+ QR+TKYPLL+ I++H+ G E + L A +E+L V+E + Q E
Sbjct: 869 LQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTE 928
Query: 437 KGARLQEIYNRMD----PRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLV 492
RL+ R+D RA P+ + F +L RK+IH+G L W+ + + D+ V
Sbjct: 929 NRHRLEGYQKRLDATALERASNPLAAE--FKSLDLTTRKMIHEGPLTWRISKDKTLDLHV 986
Query: 493 LLMTDVLVFLQEKDQKYIFPTLDKPS------------VVSLQNLIVRDIANQEKGMFLI 540
LL+ D+LV LQ++D+K + K + V+ L +++R +A ++ F+I
Sbjct: 987 LLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFII 1046
Query: 541 SAA---PPEMYEVHTASRDDRSTWIRVIQQSVR 570
+ PP++YE+ + D++TW+ +++++VR
Sbjct: 1047 CTSKLGPPQIYELVALTSSDKNTWMELLEEAVR 1079
>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
sapiens]
Length = 1544
Score = 171 bits (433), Expect = 3e-42
Identities = 138/546 (25%), Positives = 248/546 (45%), Gaps = 56/546 (10%)
Query: 107 SVSLRSKTTIRERPSSAIYPSDSFRQSLLGS----RRGRSSLSLAKSVSTTNIAGHFNDE 162
S LR E + P++S G+ G+ + + +K V T+ G D
Sbjct: 643 SAKLRQSGLANEGTDAGYLPANSMSSVASGASFSQEGGKENDTGSKQVGETSAPGDTLDG 702
Query: 163 SPLGLRRILSQSTDSLN-MRNRTLSVESLID----------EEVIYSELMSDFEMDEKDF 211
+P L + L+ ++ VE + + + V + E S+ E E D
Sbjct: 703 TPRTLNTVFDFPPPPLDQVQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFENDL 762
Query: 212 AAD--SWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELH 269
D +W V L K +K+Q+VI EL TE HVRTLK++ ++F + E
Sbjct: 763 ETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGI 822
Query: 270 LEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPS 329
L P ++ +F ++++ +H Q+ R++ VI ++G+ L++ FSGP
Sbjct: 823 LSPSELRKIFSNLEDILQLHIGLNEQMKAVRKR------NETSVIDQIGEDLLTWFSGPG 876
Query: 330 AEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQR 389
E++ + FCS AL++ K +D RFQ F++ + +R +++ I QR
Sbjct: 877 EEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQR 936
Query: 390 ITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMD 449
+TKYPLL+ I +++ ER+ + A +++L+ V++ + + E RL++ R+D
Sbjct: 937 LTKYPLLLDNIAKYTEW-PTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLD 995
Query: 450 PRA--QTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQ 507
+ + P +L +RK+IH+G L+WK + D+ LL+ D+LV LQ++D
Sbjct: 996 TSSLKLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDD 1055
Query: 508 KYIFPTLDK------------PSVVSLQNLIVRDIANQEKGMFLISAAP--PEMYEVHTA 553
+ + K V+ L ++VR +A K +F+IS + ++YE+
Sbjct: 1056 RLVLRCHSKILASTADSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQ 1115
Query: 554 SRDDRSTWIRVI--------QQSVRTCPSREDFPLIETEDEAYLRRIKME--------LQ 597
+ +++ W +I +QS + P + P DE ++K E LQ
Sbjct: 1116 TVSEKTVWQDLICRMAASVKEQSTKPIPLPQSTPGEGDNDEEDPSKLKEEQHGISVTGLQ 1175
Query: 598 QKDRAL 603
DR L
Sbjct: 1176 SPDRDL 1181
>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1
[Homo sapiens]
Length = 927
Score = 168 bits (425), Expect = 3e-41
Identities = 142/528 (26%), Positives = 245/528 (46%), Gaps = 65/528 (12%)
Query: 216 WSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVV 275
W V L K +K+Q+VI EL+ TE HVR L+++ LF M E L +
Sbjct: 413 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 472
Query: 276 QGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCK 335
Q +FP +DEL ++H+ FL +L++RR+++ ++I +GD+L+++F G K
Sbjct: 473 QNIFPSLDELIEVHSLFLDRLMKRRQES-------GYLIEEIGDVLLARFDGAEGSWFQK 525
Query: 336 TYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPL 395
S FCSR S AL+ K +D RF F+++ +R +++ I QR+TKYPL
Sbjct: 526 ISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPL 585
Query: 396 LISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMD--PRAQ 453
L+ I Q++ ER+ + A +E+L +V++ + +E RL++ R+D Q
Sbjct: 586 LLQSIGQNTEE-PTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQ 644
Query: 454 TPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIF-- 511
+ P F ++ ++KL+H+G L W+ + +V VLL+ D+L+ LQ +D++ +
Sbjct: 645 SSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKS 704
Query: 512 ------PTLDKPS----VVSLQNLIVRDIANQEKGMFLISAAPPE--MYEVHTASRDDRS 559
PT D + V+ L + + R++A K +++ E +YE+ + +R
Sbjct: 705 HSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERK 764
Query: 560 TWIRVIQQSV--------------RTCPSREDFPLIETED-----------EAYLRRIKM 594
W +I ++ R PS PL+ + + +A RI
Sbjct: 765 NWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILS 824
Query: 595 EL------QQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSESLESP 648
+L + + LR+ + L + F AEED G+G P G+ L
Sbjct: 825 DLLPFCRPGPEGQLAATALRKVLSL--KQLLFPAEEDNGAGP--PRDGDGVPGGGPLSPA 880
Query: 649 RGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSP 696
R + + ++ + E +K L E L PL GGN+ P
Sbjct: 881 RTQEIQENLLSLEETMKQL------EELEEEFCRLRPLLSQLGGNSVP 922
>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3
[Homo sapiens]
Length = 879
Score = 168 bits (425), Expect = 3e-41
Identities = 142/528 (26%), Positives = 245/528 (46%), Gaps = 65/528 (12%)
Query: 216 WSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVV 275
W V L K +K+Q+VI EL+ TE HVR L+++ LF M E L +
Sbjct: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 424
Query: 276 QGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCK 335
Q +FP +DEL ++H+ FL +L++RR+++ ++I +GD+L+++F G K
Sbjct: 425 QNIFPSLDELIEVHSLFLDRLMKRRQES-------GYLIEEIGDVLLARFDGAEGSWFQK 477
Query: 336 TYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPL 395
S FCSR S AL+ K +D RF F+++ +R +++ I QR+TKYPL
Sbjct: 478 ISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPL 537
Query: 396 LISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMD--PRAQ 453
L+ I Q++ ER+ + A +E+L +V++ + +E RL++ R+D Q
Sbjct: 538 LLQSIGQNTEE-PTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQ 596
Query: 454 TPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIF-- 511
+ P F ++ ++KL+H+G L W+ + +V VLL+ D+L+ LQ +D++ +
Sbjct: 597 SSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKS 656
Query: 512 ------PTLDKPS----VVSLQNLIVRDIANQEKGMFLISAAPPE--MYEVHTASRDDRS 559
PT D + V+ L + + R++A K +++ E +YE+ + +R
Sbjct: 657 HSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERK 716
Query: 560 TWIRVIQQSV--------------RTCPSREDFPLIETED-----------EAYLRRIKM 594
W +I ++ R PS PL+ + + +A RI
Sbjct: 717 NWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILS 776
Query: 595 EL------QQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSESLESP 648
+L + + LR+ + L + F AEED G+G P G+ L
Sbjct: 777 DLLPFCRPGPEGQLAATALRKVLSL--KQLLFPAEEDNGAGP--PRDGDGVPGGGPLSPA 832
Query: 649 RGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSP 696
R + + ++ + E +K L E L PL GGN+ P
Sbjct: 833 RTQEIQENLLSLEETMKQL------EELEEEFCRLRPLLSQLGGNSVP 874
>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2
[Homo sapiens]
Length = 912
Score = 168 bits (425), Expect = 3e-41
Identities = 142/528 (26%), Positives = 245/528 (46%), Gaps = 65/528 (12%)
Query: 216 WSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVV 275
W V L K +K+Q+VI EL+ TE HVR L+++ LF M E L +
Sbjct: 398 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 457
Query: 276 QGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCK 335
Q +FP +DEL ++H+ FL +L++RR+++ ++I +GD+L+++F G K
Sbjct: 458 QNIFPSLDELIEVHSLFLDRLMKRRQES-------GYLIEEIGDVLLARFDGAEGSWFQK 510
Query: 336 TYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPL 395
S FCSR S AL+ K +D RF F+++ +R +++ I QR+TKYPL
Sbjct: 511 ISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPL 570
Query: 396 LISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMD--PRAQ 453
L+ I Q++ ER+ + A +E+L +V++ + +E RL++ R+D Q
Sbjct: 571 LLQSIGQNTEE-PTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQ 629
Query: 454 TPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIF-- 511
+ P F ++ ++KL+H+G L W+ + +V VLL+ D+L+ LQ +D++ +
Sbjct: 630 SSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKS 689
Query: 512 ------PTLDKPS----VVSLQNLIVRDIANQEKGMFLISAAPPE--MYEVHTASRDDRS 559
PT D + V+ L + + R++A K +++ E +YE+ + +R
Sbjct: 690 HSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERK 749
Query: 560 TWIRVIQQSV--------------RTCPSREDFPLIETED-----------EAYLRRIKM 594
W +I ++ R PS PL+ + + +A RI
Sbjct: 750 NWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILS 809
Query: 595 EL------QQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSESLESP 648
+L + + LR+ + L + F AEED G+G P G+ L
Sbjct: 810 DLLPFCRPGPEGQLAATALRKVLSL--KQLLFPAEEDNGAGP--PRDGDGVPGGGPLSPA 865
Query: 649 RGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSP 696
R + + ++ + E +K L E L PL GGN+ P
Sbjct: 866 RTQEIQENLLSLEETMKQL------EELEEEFCRLRPLLSQLGGNSVP 907
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 87.8 bits (216), Expect = 5e-17
Identities = 93/356 (26%), Positives = 160/356 (44%), Gaps = 47/356 (13%)
Query: 234 KQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFL 293
K+Q I+ELIQTE ++ L+++ +F+ M E L G + +F EL +T+ L
Sbjct: 1182 KRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLL 1241
Query: 294 SQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKE 353
L R++ + +GD+L ++ S A Y FCS L ++
Sbjct: 1242 KALRVRKKTG-----GEKMPVQMIGDILAAELSHMQA------YIRFCSCQLNGAALLQQ 1290
Query: 354 LYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQD 413
D F++F++K+ K + +L QRIT+YPLLI IL+++ +
Sbjct: 1291 KTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSS 1350
Query: 414 LTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGREELL----- 468
L AL +EL S V+EG+ + E RL+ I Q V +G E+L+
Sbjct: 1351 LKLALERAEELCSQVNEGVREKENSDRLEWI--------QAHVQCEGL--AEQLIFNSLT 1400
Query: 469 ----RRKLIHDGCLLWKTATGR------FKDVLVLLMTDVLVFLQEKDQKYIFPTLDK-- 516
RKL+H G L+KT + + F D L LL V F + +F +
Sbjct: 1401 NCLGPRKLLHSG-KLYKTKSNKELHGFLFNDFL-LLTYMVKQFAVSSGSEKLFSSKSNAQ 1458
Query: 517 ----PSVVSLQNLIVR--DIANQEKGMFLISAAPPEMYEVHTASRDDRSTWIRVIQ 566
+ + L ++V+ + ++ +F IS +Y + T + ++R+ W++ I+
Sbjct: 1459 FKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHI-DRVYTLRTDNINERTAWVQKIK 1513
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 87.8 bits (216), Expect = 5e-17
Identities = 93/356 (26%), Positives = 160/356 (44%), Gaps = 47/356 (13%)
Query: 234 KQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFL 293
K+Q I+ELIQTE ++ L+++ +F+ M E L G + +F EL +T+ L
Sbjct: 1209 KRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLL 1268
Query: 294 SQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKE 353
L R++ + +GD+L ++ S A Y FCS L ++
Sbjct: 1269 KALRVRKKTG-----GEKMPVQMIGDILAAELSHMQA------YIRFCSCQLNGAALLQQ 1317
Query: 354 LYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQD 413
D F++F++K+ K + +L QRIT+YPLLI IL+++ +
Sbjct: 1318 KTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSS 1377
Query: 414 LTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGREELL----- 468
L AL +EL S V+EG+ + E RL+ I Q V +G E+L+
Sbjct: 1378 LKLALERAEELCSQVNEGVREKENSDRLEWI--------QAHVQCEGL--AEQLIFNSLT 1427
Query: 469 ----RRKLIHDGCLLWKTATGR------FKDVLVLLMTDVLVFLQEKDQKYIFPTLDK-- 516
RKL+H G L+KT + + F D L LL V F + +F +
Sbjct: 1428 NCLGPRKLLHSG-KLYKTKSNKELHGFLFNDFL-LLTYMVKQFAVSSGSEKLFSSKSNAQ 1485
Query: 517 ----PSVVSLQNLIVR--DIANQEKGMFLISAAPPEMYEVHTASRDDRSTWIRVIQ 566
+ + L ++V+ + ++ +F IS +Y + T + ++R+ W++ I+
Sbjct: 1486 FKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHI-DRVYTLRTDNINERTAWVQKIK 1540
Score = 33.5 bits (75), Expect = 1.0
Identities = 41/161 (25%), Positives = 67/161 (41%), Gaps = 26/161 (16%)
Query: 718 SDSSQRDRNGNQLR--SPQEEALQRLVNLYGLLHGL--------------QAAVAQQDTL 761
S S+ D NQL+ + + LQ L++L L+ L Q A+ Q +
Sbjct: 608 SKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKI 667
Query: 762 MEARFPEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALLQRQHALLQEELRRCR 821
+ E +R +L + + EA R KQ E + L +EE + +
Sbjct: 668 KRDKLKEIERKRLELMQKKKLEDEAARKA-------KQGKENLWKEN---LRKEEEEKQK 717
Query: 822 RLGEERATEAGSLEARLRESEQARALLEREAEEARRQLAAL 862
RL EE+ E E R E +Q + +AEE +R+ A++
Sbjct: 718 RLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASV 758
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 81.3 bits (199), Expect = 4e-15
Identities = 59/211 (27%), Positives = 101/211 (47%), Gaps = 11/211 (5%)
Query: 234 KQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFL 293
K+Q I+ELI TE ++V L+++T +F+ ++E L V +F EL + + L
Sbjct: 1237 KRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIMCNIKLL 1296
Query: 294 SQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKE 353
L R++ S + +GD+L +Q + Y FCSR L ++
Sbjct: 1297 KALRVRKKM-----SGEKMPVKMIGDILSAQLPH------MQPYIRFCSRQLNGAALIQQ 1345
Query: 354 LYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQD 413
F++F++++ K + IL QR+T+YPL+I IL+++ +
Sbjct: 1346 KTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSH 1405
Query: 414 LTTALGLVKELLSNVDEGIYQLEKGARLQEI 444
L AL +EL S V+EG+ + E RL+ I
Sbjct: 1406 LKHALEKAEELCSQVNEGVREKENSDRLEWI 1436
>gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
Length = 725
Score = 77.0 bits (188), Expect = 8e-14
Identities = 86/392 (21%), Positives = 169/392 (43%), Gaps = 43/392 (10%)
Query: 188 ESLIDEEV--IYSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQT 245
E +D +V + + +D ++ E+ + ++ A + L QH K + EL+ T
Sbjct: 110 EMALDSQVPKVTPQEEADSDVGEEPDSENTPQKADKDAGLAQHSGP-QKLLHIAQELLHT 168
Query: 246 ELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALC 305
E +V+ L ++ ++F T L + + P V+ G+F + + H +FL L+ R
Sbjct: 169 EETYVKRLHLLDQVFCT-RLTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTR----- 222
Query: 306 PGSTRNFVIH-RLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQF 364
T + + RLGD+L K Y E+ +A+ L R F+
Sbjct: 223 --ITEEWDTNPRLGDIL------QKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDV 274
Query: 365 IRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKEL 424
+ + + V +Q +L QR+ +Y LL+ L+ +R+D +L L+
Sbjct: 275 VHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTA 334
Query: 425 LSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGREELLR--RKLIHDGCLLWKT 482
++ + I ++EK +L E+Y ++ G E+++ +LI +G + +
Sbjct: 335 ANHSNAAIRKVEKMHKLLEVYEQLG-------------GEEDIVNPANELIKEGQIQKLS 381
Query: 483 A-TGRFKDVLVLLMTDVLVF----LQEKDQKYIFPTLDKPSVVSLQNLIVRDIANQEKGM 537
A G +D + L ++++ L+ QK F +K + LQ V+DI
Sbjct: 382 AKNGTPQDRHLFLFNSMILYCVPKLRLMGQK--FSVREKMDISGLQ---VQDIVKPNTAH 436
Query: 538 FLISAAPPEMYEVHTASRDDRSTWIRVIQQSV 569
I E+ T + +++ WI++IQ ++
Sbjct: 437 TFIITGRKRSLELQTRTEEEKKEWIQIIQATI 468
>gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
Length = 725
Score = 77.0 bits (188), Expect = 8e-14
Identities = 86/392 (21%), Positives = 169/392 (43%), Gaps = 43/392 (10%)
Query: 188 ESLIDEEV--IYSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQT 245
E +D +V + + +D ++ E+ + ++ A + L QH K + EL+ T
Sbjct: 110 EMALDSQVPKVTPQEEADSDVGEEPDSENTPQKADKDAGLAQHSGP-QKLLHIAQELLHT 168
Query: 246 ELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALC 305
E +V+ L ++ ++F T L + + P V+ G+F + + H +FL L+ R
Sbjct: 169 EETYVKRLHLLDQVFCT-RLTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTR----- 222
Query: 306 PGSTRNFVIH-RLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQF 364
T + + RLGD+L K Y E+ +A+ L R F+
Sbjct: 223 --ITEEWDTNPRLGDIL------QKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDV 274
Query: 365 IRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKEL 424
+ + + V +Q +L QR+ +Y LL+ L+ +R+D +L L+
Sbjct: 275 VHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTA 334
Query: 425 LSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGREELLR--RKLIHDGCLLWKT 482
++ + I ++EK +L E+Y ++ G E+++ +LI +G + +
Sbjct: 335 ANHSNAAIRKVEKMHKLLEVYEQLG-------------GEEDIVNPANELIKEGQIQKLS 381
Query: 483 A-TGRFKDVLVLLMTDVLVF----LQEKDQKYIFPTLDKPSVVSLQNLIVRDIANQEKGM 537
A G +D + L ++++ L+ QK F +K + LQ V+DI
Sbjct: 382 AKNGTPQDRHLFLFNSMILYCVPKLRLMGQK--FSVREKMDISGLQ---VQDIVKPNTAH 436
Query: 538 FLISAAPPEMYEVHTASRDDRSTWIRVIQQSV 569
I E+ T + +++ WI++IQ ++
Sbjct: 437 TFIITGRKRSLELQTRTEEEKKEWIQIIQATI 468
>gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]
Length = 709
Score = 73.2 bits (178), Expect = 1e-12
Identities = 88/425 (20%), Positives = 177/425 (41%), Gaps = 53/425 (12%)
Query: 220 VDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQ--- 276
V+ L Q E K+Q+ ++E++ +E + +L I+ F L+ L V Q
Sbjct: 270 VELGILDQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEF----LQSKELRATVTQMEH 325
Query: 277 -GLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCK 335
LF + ++ RF L +R + + ++ + D+L AE+
Sbjct: 326 HHLFSNILDVLGASQRFFEDLEQRHKAQV--------LVEDISDILEEH-----AEKHFH 372
Query: 336 TYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPL 395
Y +CS + ++L + + F++ +R++ R + ++L QR+T+ PL
Sbjct: 373 PYIAYCSNEVYQQRTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPL 432
Query: 396 LISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTP 455
L+ + + G E + + AL + +L+ +EG +++E+ ++ ++ ++D
Sbjct: 433 LMDTLCLKTQGHSERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKVKS 492
Query: 456 VPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDV------LVLLMTDVLVFLQEK-DQK 508
+P R L+ G L TG F+ + + L DVLV ++K ++
Sbjct: 493 LPLIS-------ASRWLLKRGELFLVEETGLFRKIASRPTCYLFLFNDVLVVTKKKSEES 545
Query: 509 YIFPTLDKPSVVSLQNLIVRDIANQEKGMFLISAAPP-------------EMYEVHTASR 555
Y+ + + + ++ + ++ G S P E + + S
Sbjct: 546 YMVQDYAQMNHIQVEKIEPSELPLPGGGNRSSSVPHPFQVTLLRNSEGRQEQLLLSSDSA 605
Query: 556 DDRSTWIRVIQQSVRT---CPSREDFPLIETEDEAYLRRI-KMELQQKDRALVELLREKV 611
DR+ WI + S R S+ D P +E + ++ ++ LQQ D LV L +E
Sbjct: 606 SDRARWIVALTHSERQWQGLSSKGDLPQVEITKAFFAKQADEVTLQQADVVLV-LQQEDG 664
Query: 612 GLFAE 616
L+ E
Sbjct: 665 WLYGE 669
>gi|38373682 pleckstrin homology domain containing family G member 5
isoform a [Homo sapiens]
Length = 1006
Score = 72.8 bits (177), Expect = 1e-12
Identities = 116/542 (21%), Positives = 213/542 (39%), Gaps = 109/542 (20%)
Query: 214 DSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLF--------RTGML 265
DSW +D ++ + QQ+ ++EL+ TE ++R L+++ LF +G+L
Sbjct: 318 DSWRELIDGH--EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLL 375
Query: 266 EELHLEPGVVQGLFPCVDELSDIHTRF----LSQLLERRRQALCPGSTRNFVIHRLGDLL 321
E+ E LF + E++ +H R ++ +LE+ R R + + GD L
Sbjct: 376 CEVEAER-----LFSNIPEIAQLHRRLWASVMAPVLEKAR--------RTRALLQPGDFL 422
Query: 322 --ISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGV 379
F + K Y +C ++ + L + F+ +I + +R +
Sbjct: 423 KGFKMFGS-----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKL 477
Query: 380 QECILLVTQRITKYPLLISRILQHSHGIEEER--QDLTTALGLVKELLSNVDEGIYQLEK 437
+ + QR+TKYPLL+ +L+ + EE R + + +G V+ + +V+ + Q ++
Sbjct: 478 SDMLAKPHQRLTKYPLLLKSVLRKT---EEPRAKEAVVAMIGSVERFIHHVNACMRQRQE 534
Query: 438 GARLQEIYNRMDP---------------------RAQTPVPGKGPFGREELLRRKLIHDG 476
RL + +R+D P+PG P EE R+L+ +G
Sbjct: 535 RQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASP---EE--TRQLLLEG 589
Query: 477 CLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLDKPSVVSLQNLIVRDIANQEKG 536
L K DV L TD+L+ + + + P +V ++ R++ ++ G
Sbjct: 590 SLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLV--DKIVCREL--RDPG 645
Query: 537 MFLI-----SAAPPEMYEVHTASRDDRSTWIRVI-------QQSVRTCPSREDFPLIETE 584
FL+ + Y + + W+ I QQ P PL E
Sbjct: 646 SFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLE 705
Query: 585 DEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSES 644
+E + + E ++++ + E+ G S + PT+ R +S
Sbjct: 706 EEEDEQEEEEEEEEEEE-------------------EGEDSGTSAASSPTIMR-----KS 741
Query: 645 LESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSPGVTANGEA 704
SP + D E L ++V PG + L +P + P S TS TA+
Sbjct: 742 SGSPDSQHCASDG--STETLAMVVVEPG-DTLSSPEFDSGPFSSQS-DETSLSTTASSAT 797
Query: 705 RT 706
T
Sbjct: 798 PT 799
>gi|111154084 pleckstrin homology domain containing family G member
5 isoform b [Homo sapiens]
Length = 1083
Score = 72.8 bits (177), Expect = 1e-12
Identities = 116/542 (21%), Positives = 213/542 (39%), Gaps = 109/542 (20%)
Query: 214 DSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLF--------RTGML 265
DSW +D ++ + QQ+ ++EL+ TE ++R L+++ LF +G+L
Sbjct: 395 DSWRELIDGH--EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLL 452
Query: 266 EELHLEPGVVQGLFPCVDELSDIHTRF----LSQLLERRRQALCPGSTRNFVIHRLGDLL 321
E+ E LF + E++ +H R ++ +LE+ R R + + GD L
Sbjct: 453 CEVEAER-----LFSNIPEIAQLHRRLWASVMAPVLEKAR--------RTRALLQPGDFL 499
Query: 322 --ISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGV 379
F + K Y +C ++ + L + F+ +I + +R +
Sbjct: 500 KGFKMFGS-----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKL 554
Query: 380 QECILLVTQRITKYPLLISRILQHSHGIEEER--QDLTTALGLVKELLSNVDEGIYQLEK 437
+ + QR+TKYPLL+ +L+ + EE R + + +G V+ + +V+ + Q ++
Sbjct: 555 SDMLAKPHQRLTKYPLLLKSVLRKT---EEPRAKEAVVAMIGSVERFIHHVNACMRQRQE 611
Query: 438 GARLQEIYNRMDP---------------------RAQTPVPGKGPFGREELLRRKLIHDG 476
RL + +R+D P+PG P EE R+L+ +G
Sbjct: 612 RQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASP---EE--TRQLLLEG 666
Query: 477 CLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLDKPSVVSLQNLIVRDIANQEKG 536
L K DV L TD+L+ + + + P +V ++ R++ ++ G
Sbjct: 667 SLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLV--DKIVCREL--RDPG 722
Query: 537 MFLI-----SAAPPEMYEVHTASRDDRSTWIRVI-------QQSVRTCPSREDFPLIETE 584
FL+ + Y + + W+ I QQ P PL E
Sbjct: 723 SFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLE 782
Query: 585 DEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSES 644
+E + + E ++++ + E+ G S + PT+ R +S
Sbjct: 783 EEEDEQEEEEEEEEEEE-------------------EGEDSGTSAASSPTIMR-----KS 818
Query: 645 LESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSPGVTANGEA 704
SP + D E L ++V PG + L +P + P S TS TA+
Sbjct: 819 SGSPDSQHCASDG--STETLAMVVVEPG-DTLSSPEFDSGPFSSQS-DETSLSTTASSAT 874
Query: 705 RT 706
T
Sbjct: 875 PT 876
>gi|111154088 pleckstrin homology domain containing family G member
5 isoform a [Homo sapiens]
Length = 1006
Score = 72.8 bits (177), Expect = 1e-12
Identities = 116/542 (21%), Positives = 213/542 (39%), Gaps = 109/542 (20%)
Query: 214 DSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLF--------RTGML 265
DSW +D ++ + QQ+ ++EL+ TE ++R L+++ LF +G+L
Sbjct: 318 DSWRELIDGH--EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLL 375
Query: 266 EELHLEPGVVQGLFPCVDELSDIHTRF----LSQLLERRRQALCPGSTRNFVIHRLGDLL 321
E+ E LF + E++ +H R ++ +LE+ R R + + GD L
Sbjct: 376 CEVEAER-----LFSNIPEIAQLHRRLWASVMAPVLEKAR--------RTRALLQPGDFL 422
Query: 322 --ISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGV 379
F + K Y +C ++ + L + F+ +I + +R +
Sbjct: 423 KGFKMFGS-----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKL 477
Query: 380 QECILLVTQRITKYPLLISRILQHSHGIEEER--QDLTTALGLVKELLSNVDEGIYQLEK 437
+ + QR+TKYPLL+ +L+ + EE R + + +G V+ + +V+ + Q ++
Sbjct: 478 SDMLAKPHQRLTKYPLLLKSVLRKT---EEPRAKEAVVAMIGSVERFIHHVNACMRQRQE 534
Query: 438 GARLQEIYNRMDP---------------------RAQTPVPGKGPFGREELLRRKLIHDG 476
RL + +R+D P+PG P EE R+L+ +G
Sbjct: 535 RQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASP---EE--TRQLLLEG 589
Query: 477 CLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLDKPSVVSLQNLIVRDIANQEKG 536
L K DV L TD+L+ + + + P +V ++ R++ ++ G
Sbjct: 590 SLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLV--DKIVCREL--RDPG 645
Query: 537 MFLI-----SAAPPEMYEVHTASRDDRSTWIRVI-------QQSVRTCPSREDFPLIETE 584
FL+ + Y + + W+ I QQ P PL E
Sbjct: 646 SFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLE 705
Query: 585 DEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSES 644
+E + + E ++++ + E+ G S + PT+ R +S
Sbjct: 706 EEEDEQEEEEEEEEEEE-------------------EGEDSGTSAASSPTIMR-----KS 741
Query: 645 LESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSPGVTANGEA 704
SP + D E L ++V PG + L +P + P S TS TA+
Sbjct: 742 SGSPDSQHCASDG--STETLAMVVVEPG-DTLSSPEFDSGPFSSQS-DETSLSTTASSAT 797
Query: 705 RT 706
T
Sbjct: 798 PT 799
>gi|111154080 pleckstrin homology domain containing family G member
5 isoform a [Homo sapiens]
Length = 1006
Score = 72.8 bits (177), Expect = 1e-12
Identities = 116/542 (21%), Positives = 213/542 (39%), Gaps = 109/542 (20%)
Query: 214 DSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLF--------RTGML 265
DSW +D ++ + QQ+ ++EL+ TE ++R L+++ LF +G+L
Sbjct: 318 DSWRELIDGH--EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLL 375
Query: 266 EELHLEPGVVQGLFPCVDELSDIHTRF----LSQLLERRRQALCPGSTRNFVIHRLGDLL 321
E+ E LF + E++ +H R ++ +LE+ R R + + GD L
Sbjct: 376 CEVEAER-----LFSNIPEIAQLHRRLWASVMAPVLEKAR--------RTRALLQPGDFL 422
Query: 322 --ISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGV 379
F + K Y +C ++ + L + F+ +I + +R +
Sbjct: 423 KGFKMFGS-----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKL 477
Query: 380 QECILLVTQRITKYPLLISRILQHSHGIEEER--QDLTTALGLVKELLSNVDEGIYQLEK 437
+ + QR+TKYPLL+ +L+ + EE R + + +G V+ + +V+ + Q ++
Sbjct: 478 SDMLAKPHQRLTKYPLLLKSVLRKT---EEPRAKEAVVAMIGSVERFIHHVNACMRQRQE 534
Query: 438 GARLQEIYNRMDP---------------------RAQTPVPGKGPFGREELLRRKLIHDG 476
RL + +R+D P+PG P EE R+L+ +G
Sbjct: 535 RQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASP---EE--TRQLLLEG 589
Query: 477 CLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLDKPSVVSLQNLIVRDIANQEKG 536
L K DV L TD+L+ + + + P +V ++ R++ ++ G
Sbjct: 590 SLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLV--DKIVCREL--RDPG 645
Query: 537 MFLI-----SAAPPEMYEVHTASRDDRSTWIRVI-------QQSVRTCPSREDFPLIETE 584
FL+ + Y + + W+ I QQ P PL E
Sbjct: 646 SFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLE 705
Query: 585 DEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSES 644
+E + + E ++++ + E+ G S + PT+ R +S
Sbjct: 706 EEEDEQEEEEEEEEEEE-------------------EGEDSGTSAASSPTIMR-----KS 741
Query: 645 LESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSPGVTANGEA 704
SP + D E L ++V PG + L +P + P S TS TA+
Sbjct: 742 SGSPDSQHCASDG--STETLAMVVVEPG-DTLSSPEFDSGPFSSQS-DETSLSTTASSAT 797
Query: 705 RT 706
T
Sbjct: 798 PT 799
>gi|111154078 pleckstrin homology domain containing family G member
5 isoform c [Homo sapiens]
Length = 1062
Score = 72.8 bits (177), Expect = 1e-12
Identities = 116/542 (21%), Positives = 213/542 (39%), Gaps = 109/542 (20%)
Query: 214 DSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLF--------RTGML 265
DSW +D ++ + QQ+ ++EL+ TE ++R L+++ LF +G+L
Sbjct: 374 DSWRELIDGH--EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLL 431
Query: 266 EELHLEPGVVQGLFPCVDELSDIHTRF----LSQLLERRRQALCPGSTRNFVIHRLGDLL 321
E+ E LF + E++ +H R ++ +LE+ R R + + GD L
Sbjct: 432 CEVEAER-----LFSNIPEIAQLHRRLWASVMAPVLEKAR--------RTRALLQPGDFL 478
Query: 322 --ISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGV 379
F + K Y +C ++ + L + F+ +I + +R +
Sbjct: 479 KGFKMFGS-----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKL 533
Query: 380 QECILLVTQRITKYPLLISRILQHSHGIEEER--QDLTTALGLVKELLSNVDEGIYQLEK 437
+ + QR+TKYPLL+ +L+ + EE R + + +G V+ + +V+ + Q ++
Sbjct: 534 SDMLAKPHQRLTKYPLLLKSVLRKT---EEPRAKEAVVAMIGSVERFIHHVNACMRQRQE 590
Query: 438 GARLQEIYNRMDP---------------------RAQTPVPGKGPFGREELLRRKLIHDG 476
RL + +R+D P+PG P EE R+L+ +G
Sbjct: 591 RQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASP---EE--TRQLLLEG 645
Query: 477 CLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLDKPSVVSLQNLIVRDIANQEKG 536
L K DV L TD+L+ + + + P +V ++ R++ ++ G
Sbjct: 646 SLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLV--DKIVCREL--RDPG 701
Query: 537 MFLI-----SAAPPEMYEVHTASRDDRSTWIRVI-------QQSVRTCPSREDFPLIETE 584
FL+ + Y + + W+ I QQ P PL E
Sbjct: 702 SFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLE 761
Query: 585 DEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSES 644
+E + + E ++++ + E+ G S + PT+ R +S
Sbjct: 762 EEEDEQEEEEEEEEEEE-------------------EGEDSGTSAASSPTIMR-----KS 797
Query: 645 LESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSPGVTANGEA 704
SP + D E L ++V PG + L +P + P S TS TA+
Sbjct: 798 SGSPDSQHCASDG--STETLAMVVVEPG-DTLSSPEFDSGPFSSQS-DETSLSTTASSAT 853
Query: 705 RT 706
T
Sbjct: 854 PT 855
>gi|222080070 pleckstrin homology domain-containing family G member
6 isoform b [Homo sapiens]
Length = 758
Score = 71.6 bits (174), Expect = 3e-12
Identities = 108/422 (25%), Positives = 176/422 (41%), Gaps = 78/422 (18%)
Query: 226 QQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELH---LEPGVVQGLFPCV 282
++ +E+ QQ+ ++EL+ TEL +VR LKIMT L G+L L + LF V
Sbjct: 121 KEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNV 180
Query: 283 DELSDIHTRFLSQLL-ERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFC 341
L H F ++L + G + + + G L Q P Y ++C
Sbjct: 181 PSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHP--------YVQYC 232
Query: 342 SRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQE-CILLVT--QRITKYPLLIS 398
R + + +E + F F++ + KR G Q C LL+ QRITKYPLL+
Sbjct: 233 LRVKQTMAYAREQQETNPLFHAFVQWCEKH---KRSGRQMLCDLLIKPHQRITKYPLLLH 289
Query: 399 RILQHSHGIEEERQDLTTAL-----GLVKELLSNVDEGIYQLEKGARLQEI--YNRMDPR 451
+L+ S E Q+ A+ ++ + V +G Q A Q I Y ++P
Sbjct: 290 AVLKRSP--EARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPP 347
Query: 452 AQTPVPGKGPFGREELL----------RRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVF 501
+ PF +L R+L+ +G + K DV + L +DVL
Sbjct: 348 SDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVL-- 405
Query: 502 LQEKDQKYIFPTLDKPSVV----SLQNLIVRDIANQEKGMFL-------ISAAPPEMYEV 550
L K Q+ DK V+ L+ L+ + + + + + +S+A V
Sbjct: 406 LVTKPQR----KADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSA----LLV 457
Query: 551 HTASRDDRSTWIRVIQQSVRTCPSREDFPLIETEDEAYLRRIKME--LQQKDRALVELLR 608
H S DR+ W+ QQ+ +A L+++K E +QQK R L+ L R
Sbjct: 458 HCPSPTDRAQWLEKTQQA-----------------QAALQKLKAEEYVQQK-RELLTLYR 499
Query: 609 EK 610
++
Sbjct: 500 DQ 501
>gi|222080068 pleckstrin homology domain-containing family G member
6 isoform a [Homo sapiens]
Length = 790
Score = 71.6 bits (174), Expect = 3e-12
Identities = 108/422 (25%), Positives = 176/422 (41%), Gaps = 78/422 (18%)
Query: 226 QQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELH---LEPGVVQGLFPCV 282
++ +E+ QQ+ ++EL+ TEL +VR LKIMT L G+L L + LF V
Sbjct: 153 KEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNV 212
Query: 283 DELSDIHTRFLSQLL-ERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFC 341
L H F ++L + G + + + G L Q P Y ++C
Sbjct: 213 PSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHP--------YVQYC 264
Query: 342 SRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQE-CILLVT--QRITKYPLLIS 398
R + + +E + F F++ + KR G Q C LL+ QRITKYPLL+
Sbjct: 265 LRVKQTMAYAREQQETNPLFHAFVQWCEKH---KRSGRQMLCDLLIKPHQRITKYPLLLH 321
Query: 399 RILQHSHGIEEERQDLTTAL-----GLVKELLSNVDEGIYQLEKGARLQEI--YNRMDPR 451
+L+ S E Q+ A+ ++ + V +G Q A Q I Y ++P
Sbjct: 322 AVLKRSP--EARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPP 379
Query: 452 AQTPVPGKGPFGREELL----------RRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVF 501
+ PF +L R+L+ +G + K DV + L +DVL
Sbjct: 380 SDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVL-- 437
Query: 502 LQEKDQKYIFPTLDKPSVV----SLQNLIVRDIANQEKGMFL-------ISAAPPEMYEV 550
L K Q+ DK V+ L+ L+ + + + + + +S+A V
Sbjct: 438 LVTKPQR----KADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSA----LLV 489
Query: 551 HTASRDDRSTWIRVIQQSVRTCPSREDFPLIETEDEAYLRRIKME--LQQKDRALVELLR 608
H S DR+ W+ QQ+ +A L+++K E +QQK R L+ L R
Sbjct: 490 HCPSPTDRAQWLEKTQQA-----------------QAALQKLKAEEYVQQK-RELLTLYR 531
Query: 609 EK 610
++
Sbjct: 532 DQ 533
>gi|222080066 pleckstrin homology domain-containing family G member
6 isoform a [Homo sapiens]
Length = 790
Score = 71.6 bits (174), Expect = 3e-12
Identities = 108/422 (25%), Positives = 176/422 (41%), Gaps = 78/422 (18%)
Query: 226 QQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELH---LEPGVVQGLFPCV 282
++ +E+ QQ+ ++EL+ TEL +VR LKIMT L G+L L + LF V
Sbjct: 153 KEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNV 212
Query: 283 DELSDIHTRFLSQLL-ERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFC 341
L H F ++L + G + + + G L Q P Y ++C
Sbjct: 213 PSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHP--------YVQYC 264
Query: 342 SRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQE-CILLVT--QRITKYPLLIS 398
R + + +E + F F++ + KR G Q C LL+ QRITKYPLL+
Sbjct: 265 LRVKQTMAYAREQQETNPLFHAFVQWCEKH---KRSGRQMLCDLLIKPHQRITKYPLLLH 321
Query: 399 RILQHSHGIEEERQDLTTAL-----GLVKELLSNVDEGIYQLEKGARLQEI--YNRMDPR 451
+L+ S E Q+ A+ ++ + V +G Q A Q I Y ++P
Sbjct: 322 AVLKRSP--EARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPP 379
Query: 452 AQTPVPGKGPFGREELL----------RRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVF 501
+ PF +L R+L+ +G + K DV + L +DVL
Sbjct: 380 SDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVL-- 437
Query: 502 LQEKDQKYIFPTLDKPSVV----SLQNLIVRDIANQEKGMFL-------ISAAPPEMYEV 550
L K Q+ DK V+ L+ L+ + + + + + +S+A V
Sbjct: 438 LVTKPQR----KADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSA----LLV 489
Query: 551 HTASRDDRSTWIRVIQQSVRTCPSREDFPLIETEDEAYLRRIKME--LQQKDRALVELLR 608
H S DR+ W+ QQ+ +A L+++K E +QQK R L+ L R
Sbjct: 490 HCPSPTDRAQWLEKTQQA-----------------QAALQKLKAEEYVQQK-RELLTLYR 531
Query: 609 EK 610
++
Sbjct: 532 DQ 533
>gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2
[Homo sapiens]
Length = 532
Score = 69.3 bits (168), Expect = 2e-11
Identities = 52/216 (24%), Positives = 102/216 (47%), Gaps = 19/216 (8%)
Query: 216 WSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVV 275
WS D Q + +K+Q+ I+EL Q E + LK+ + + ML+ + +
Sbjct: 110 WSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQEL 169
Query: 276 QGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCK 335
+F +D L +H LSQL + R+ GST + +G +L+
Sbjct: 170 NQIFGTLDSLIPLHEELLSQLRDVRKP---DGSTEH-----VGPILVGWL------PCLS 215
Query: 336 TYSEFCSRH--SKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKY 393
+Y +CS +KAL +K+ +D R Q F+++ ++ + + + R+ KY
Sbjct: 216 SYDSYCSNQVAAKALLDHKK---QDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKY 272
Query: 394 PLLISRILQHSHGIEEERQDLTTALGLVKELLSNVD 429
PLL+ IL+H+ ++Q L A+ +++ +++ ++
Sbjct: 273 PLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEIN 308
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,632,124
Number of Sequences: 37866
Number of extensions: 1825494
Number of successful extensions: 9065
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 91
Number of HSP's successfully gapped in prelim test: 266
Number of HSP's that attempted gapping in prelim test: 8078
Number of HSP's gapped (non-prelim): 1028
length of query: 985
length of database: 18,247,518
effective HSP length: 112
effective length of query: 873
effective length of database: 14,006,526
effective search space: 12227697198
effective search space used: 12227697198
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.