Search of human proteins with 24497497

Search of human proteins with 24497497

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|24497497 solute carrier family 22 member 7 isoform a [Homo
sapiens]
         (546 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa...  1087   0.0  
gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa...  1082   0.0  
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa...   382   e-106
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa...   380   e-105
gi|24497499 solute carrier family 22 member 8 [Homo sapiens]          353   2e-97
gi|238814326 solute carrier family 22, member 20 [Homo sapiens]       347   2e-95
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa...   331   1e-90
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa...   328   8e-90
gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]          314   2e-85
gi|166064021 solute carrier family 22 (organic anion transporter...   309   5e-84
gi|8923870 solute carrier family 22 member 11 [Homo sapiens]          295   6e-80
gi|211059435 solute carrier family 22, member 24 [Homo sapiens]       291   8e-79
gi|148664184 solute carrier family 22, member 10 [Homo sapiens]       265   6e-71
gi|4507005 solute carrier family 22 member 5 [Homo sapiens]           263   4e-70
gi|11415038 solute carrier family 22 member 3 [Homo sapiens]          259   6e-69
gi|153791484 putative UST1-like organic anion transporter [Homo ...   258   1e-68
gi|42542386 solute carrier family 22 (organic anion/cation trans...   258   1e-68
gi|31542327 solute carrier family 22, member 16 [Homo sapiens]        257   2e-68
gi|24497490 solute carrier family 22 member 4 [Homo sapiens]          246   5e-65
gi|166197673 solute carrier family 22, member 15 [Homo sapiens]       242   7e-64
gi|4507001 solute carrier family 22 member 2 [Homo sapiens]           234   2e-61
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap...   226   3e-59
gi|157426885 organic cation transporter like 4 [Homo sapiens]         205   8e-53
gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]          197   3e-50
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa...   180   3e-45
gi|213021148 SVOP-like isoform 1 [Homo sapiens]                       138   1e-32
gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1...   136   6e-32
gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6...   133   4e-31
gi|24308167 SV2 related protein [Homo sapiens]                        130   2e-30
gi|63999576 solute carrier family 22, member 17 isoform b [Homo ...   124   2e-28

>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
           sapiens]
          Length = 546

 Score = 1087 bits (2811), Expect = 0.0
 Identities = 546/546 (100%), Positives = 546/546 (100%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60
           MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH
Sbjct: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60

Query: 61  QDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYD 120
           QDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYD
Sbjct: 61  QDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYD 120

Query: 121 HSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVST 180
           HSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVST
Sbjct: 121 HSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVST 180

Query: 181 LVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWTG 240
           LVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWTG
Sbjct: 181 LVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWTG 240

Query: 241 GVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHCA 300
           GVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHCA
Sbjct: 241 GVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHCA 300

Query: 301 RLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFSYY 360
           RLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFSYY
Sbjct: 301 RLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFSYY 360

Query: 361 GLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTRLL 420
           GLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTRLL
Sbjct: 361 GLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTRLL 420

Query: 421 VSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLAPL 480
           VSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLAPL
Sbjct: 421 VSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLAPL 480

Query: 481 AALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQEEEMP 540
           AALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQEEEMP
Sbjct: 481 AALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQEEEMP 540

Query: 541 MKQVQN 546
           MKQVQN
Sbjct: 541 MKQVQN 546


>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
           sapiens]
          Length = 548

 Score = 1082 bits (2798), Expect = 0.0
 Identities = 546/548 (99%), Positives = 546/548 (99%), Gaps = 2/548 (0%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60
           MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH
Sbjct: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60

Query: 61  QDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYD 120
           QDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYD
Sbjct: 61  QDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYD 120

Query: 121 HSEFSSTIATE--WDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYV 178
           HSEFSSTIATE  WDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYV
Sbjct: 121 HSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYV 180

Query: 179 STLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFW 238
           STLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFW
Sbjct: 181 STLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFW 240

Query: 239 TGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLH 298
           TGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLH
Sbjct: 241 TGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLH 300

Query: 299 CARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFS 358
           CARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFS
Sbjct: 301 CARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFS 360

Query: 359 YYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTR 418
           YYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTR
Sbjct: 361 YYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTR 420

Query: 419 LLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLA 478
           LLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLA
Sbjct: 421 LLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLA 480

Query: 479 PLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQEEE 538
           PLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQEEE
Sbjct: 481 PLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQEEE 540

Query: 539 MPMKQVQN 546
           MPMKQVQN
Sbjct: 541 MPMKQVQN 548


>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
           sapiens]
          Length = 563

 Score =  382 bits (982), Expect = e-106
 Identities = 215/548 (39%), Positives = 311/548 (56%), Gaps = 12/548 (2%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60
           M F +LL+QVGG G FQ   V L+ LP +L+  H  L  F AA+P H C  P A AN S 
Sbjct: 1   MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR-PPADANLS- 58

Query: 61  QDVWLEAHLPREPDGTLSSCLRFAYPQ-ALPNTTLGEERQSRGELEDEPATVPCSQGWEY 119
           ++  LE  LPR+  G   SCLRF  PQ  LP    G E    G      AT PC+ GW Y
Sbjct: 59  KNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLN-GTEANGTG------ATEPCTDGWIY 111

Query: 120 DHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVS 179
           D+S F STI TEWDLVC  + L + A + +  GVL+GA+ FGYL+DR GRR++L++ Y+ 
Sbjct: 112 DNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQ 171

Query: 180 TLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWT 239
           T V G  +A + ++ ++   R L+G ALAG ++  M L +EW+ +  R   G L    ++
Sbjct: 172 TAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYS 231

Query: 240 GGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHC 299
            G  LLA V Y +  WR L L V+ P     +  W+  ESARW  + G +    R L   
Sbjct: 232 LGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRV 291

Query: 300 ARLNGRPVCEDSFSQEAVSKVAAGERVVRR--PSYLDLFRTPRLRHISLCCVVVWFGVNF 357
           AR+NG+       S E +      E  + +   S ++L R P LRH+ LC  ++WF  +F
Sbjct: 292 ARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSF 351

Query: 358 SYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGT 417
           +YYGL +D+ G G+++Y  Q++FGAV+LP+KL+ +L +   GRR  Q   LL   +    
Sbjct: 352 AYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILL 411

Query: 418 RLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSL 477
             ++  D     T LAV+GK    A+F   +L+T ELYPT++RQTGMG+ + + R+G  +
Sbjct: 412 NGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIV 471

Query: 478 APLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQEE 537
           +PL ++   ++ S+P   YG + + A+   +LLPET    LP+T+QD+E + APT  +  
Sbjct: 472 SPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAG 531

Query: 538 EMPMKQVQ 545
             P K  Q
Sbjct: 532 IYPRKGKQ 539


>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
           sapiens]
          Length = 550

 Score =  380 bits (975), Expect = e-105
 Identities = 211/541 (39%), Positives = 309/541 (57%), Gaps = 12/541 (2%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60
           M F +LL+QVGG G FQ   V L+ LP +L+  H  L  F AA+P H C  P A AN S 
Sbjct: 1   MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR-PPADANLS- 58

Query: 61  QDVWLEAHLPREPDGTLSSCLRFAYPQ-ALPNTTLGEERQSRGELEDEPATVPCSQGWEY 119
           ++  LE  LPR+  G   SCLRF  PQ  LP    G E    G      AT PC+ GW Y
Sbjct: 59  KNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLN-GTEANGTG------ATEPCTDGWIY 111

Query: 120 DHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVS 179
           D+S F STI TEWDLVC  + L + A + +  GVL+GA+ FGYL+DR GRR++L++ Y+ 
Sbjct: 112 DNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQ 171

Query: 180 TLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWT 239
           T V G  +A + ++ ++   R L+G ALAG ++  M L +EW+ +  R   G L    ++
Sbjct: 172 TAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYS 231

Query: 240 GGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHC 299
            G  LLA V Y +  WR L L V+ P     +  W+  ESARW  + G +    R L   
Sbjct: 232 LGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRV 291

Query: 300 ARLNGRPVCEDSFSQEAVSKVAAGERVVRR--PSYLDLFRTPRLRHISLCCVVVWFGVNF 357
           AR+NG+       S E +      E  + +   S ++L R P LRH+ LC  ++WF  +F
Sbjct: 292 ARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSF 351

Query: 358 SYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGT 417
           +YYGL +D+ G G+++Y  Q++FGAV+LP+KL+ +L +   GRR  Q   LL   +    
Sbjct: 352 AYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILL 411

Query: 418 RLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSL 477
             ++  D     T LAV+GK    A+F   +L+T ELYPT++RQTGMG+ + + R+G  +
Sbjct: 412 NGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIV 471

Query: 478 APLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQEE 537
           +PL ++   ++ S+P   YG + + A+   +LLPET    LP+T+QD+E +    + Q++
Sbjct: 472 SPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRKGKQTRQQQ 531

Query: 538 E 538
           E
Sbjct: 532 E 532


>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
          Length = 542

 Score =  353 bits (907), Expect = 2e-97
 Identities = 203/540 (37%), Positives = 289/540 (53%), Gaps = 22/540 (4%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60
           M F E+L++VG  G FQ  +VA+L LP + +  H LL IF AA P H C     P + + 
Sbjct: 1   MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCR----PPHNAS 56

Query: 61  QDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYD 120
              W+   LP  P+G    CLRF +P   PN +L  + Q   E        PC  GW Y+
Sbjct: 57  TGPWV---LPMGPNGKPERCLRFVHP---PNASLPNDTQRAME--------PCLDGWVYN 102

Query: 121 HSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVST 180
            ++ S  I TEWDLVC    L   A + F AG+L+G +  G LSDRFGRR +L  +Y+  
Sbjct: 103 STKDS--IVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLL 160

Query: 181 LVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWTG 240
              G  +A S ++ ++ + R L G  ++G T+  + L +EW+    R +        +T 
Sbjct: 161 AASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTF 220

Query: 241 GVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHCA 300
           G  +L  + Y I  WRWL L V++P     LS WW PES RWL+  G   +A + L   A
Sbjct: 221 GQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVA 280

Query: 301 RLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYL--DLFRTPRLRHISLCCVVVWFGVNFS 358
             NG+    +  S E +      E  + +  Y   DLFR P LR ++ C  + WF   F+
Sbjct: 281 VFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFA 340

Query: 359 YYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTR 418
           YY L++ V   G+N+Y  Q++FG V++P+K +  LS+ Y GR  TQA  LL    A    
Sbjct: 341 YYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILAL 400

Query: 419 LLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLA 478
             V  D+++  TVLAV GK    ++F+  +L+TSELYPTV+RQTGMG++ L  R+G  ++
Sbjct: 401 TFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVS 460

Query: 479 PLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQEEE 538
           PL  +   V   +P + YG  ALL    AL LPET    LPETI+D+E  S      ++E
Sbjct: 461 PLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQE 520


>gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
          Length = 555

 Score =  347 bits (890), Expect = 2e-95
 Identities = 211/558 (37%), Positives = 294/558 (52%), Gaps = 24/558 (4%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60
           M F +LL+ +G  G FQL + ALL LP  LL  H  L  F AAVP H C  P      S 
Sbjct: 1   MAFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPANHTEAST 60

Query: 61  QD--VWLEAHLPREPDGTLSSCLRFAYPQ---ALPNTTLGEERQSRGELEDEPATVPCSQ 115
            D   WL A +P +  G    C RF  PQ     PN+++              AT  C  
Sbjct: 61  NDSGAWLRATIPLDQLGAPEPCRRFTKPQWALLSPNSSI-----------PGAATEGCKD 109

Query: 116 GWEYDHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLV 175
           GW Y+ S F STI  EWDLVCE + L   A + + AGVLVGA  FG L+DR G +  L+ 
Sbjct: 110 GWVYNRSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVW 169

Query: 176 AYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSS 235
           +Y+     G A+A   S+  + + R L G   +G  +  + L +EW+    RTVAG+L  
Sbjct: 170 SYLQLAASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLG 229

Query: 236 TFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRY 295
             +T G ++LA V YLIR WR L  A++ P     L  WW+PES+RWLL  G  + A + 
Sbjct: 230 YSFTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQN 289

Query: 296 LLHCARLNGRPVCEDSFSQEAVSKVAAGE--RVVRRPSYLDLFRTPRLRHISLCCVVVWF 353
           L   A +NGR    +  ++E +S     E   V    S LDLFRTP +R ++ C +V+WF
Sbjct: 290 LQKVAAMNGRKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWF 349

Query: 354 GVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTAL 413
             + +YYGL++D+   GL++Y  Q LFG +  P+ L+   ++ Y GRR T A  L+   L
Sbjct: 350 SNSVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGL 409

Query: 414 AFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRL 473
                + V    +   T  A +GK    ++F   YLFT ELYPT +RQ GMG  ++  RL
Sbjct: 410 MVIANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARL 469

Query: 474 GGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERK----S 529
           GG  APL   L      LP +++G  A+LA     +L ETR   L ETI  +ER+    S
Sbjct: 470 GGLTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERRVKEGS 529

Query: 530 APTSLQE--EEMPMKQVQ 545
           +   ++E  EE+ ++Q++
Sbjct: 530 SKKHVEEKSEEISLQQLR 547


>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
           sapiens]
          Length = 519

 Score =  331 bits (848), Expect = 1e-90
 Identities = 201/548 (36%), Positives = 283/548 (51%), Gaps = 56/548 (10%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60
           M F +LL+QVGG G FQ   V L+ LP +L+  H  L  F AA+P H C  P A AN S 
Sbjct: 1   MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR-PPADANLS- 58

Query: 61  QDVWLEAHLPREPDGTLSSCLRFAYPQ-ALPNTTLGEERQSRGELEDEPATVPCSQGWEY 119
           ++  LE  LPR+  G   SCLRF  PQ  LP    G E    G      AT PC+ GW Y
Sbjct: 59  KNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLN-GTEANGTG------ATEPCTDGWIY 111

Query: 120 DHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVS 179
           D+S F STI TEWDLVC  + L + A + +  GVL+GA+ FGYL+DR GRR++L++ Y+ 
Sbjct: 112 DNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQ 171

Query: 180 TLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWT 239
           T V G  +A + ++ ++   R L+G ALAG ++  M L +EW+ +  R   G L    ++
Sbjct: 172 TAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYS 231

Query: 240 GGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHC 299
            G  LLA V Y +  WR L L V+ P     +  W+  ESARW  + G +    R L   
Sbjct: 232 LGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRV 291

Query: 300 ARLNGRPVCEDSFSQEAVSKVAAGERVVRR--PSYLDLFRTPRLRHISLCCVVVWFGVNF 357
           AR+NG+       S E +      E  + +   S ++L R P LRH+ LC  ++WF  +F
Sbjct: 292 ARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSF 351

Query: 358 SYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGT 417
           +YYGL +D+ G G+++Y  Q++FGAV+LP+KL+ +L +   GRR  Q   LL   +    
Sbjct: 352 AYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILL 411

Query: 418 RLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSL 477
             ++  D     T LAV+GK    A+F   +L+T ELYPT++R                 
Sbjct: 412 NGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR----------------- 454

Query: 478 APLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQEE 537
                                         +LLPET    LP+T+QD+E + APT  +  
Sbjct: 455 ---------------------------AVTVLLPETLGQPLPDTVQDLESRWAPTQKEAG 487

Query: 538 EMPMKQVQ 545
             P K  Q
Sbjct: 488 IYPRKGKQ 495


>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
           sapiens]
          Length = 506

 Score =  328 bits (841), Expect = 8e-90
 Identities = 197/541 (36%), Positives = 281/541 (51%), Gaps = 56/541 (10%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60
           M F +LL+QVGG G FQ   V L+ LP +L+  H  L  F AA+P H C  P A AN S 
Sbjct: 1   MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR-PPADANLS- 58

Query: 61  QDVWLEAHLPREPDGTLSSCLRFAYPQ-ALPNTTLGEERQSRGELEDEPATVPCSQGWEY 119
           ++  LE  LPR+  G   SCLRF  PQ  LP    G E    G      AT PC+ GW Y
Sbjct: 59  KNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLN-GTEANGTG------ATEPCTDGWIY 111

Query: 120 DHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVS 179
           D+S F STI TEWDLVC  + L + A + +  GVL+GA+ FGYL+DR GRR++L++ Y+ 
Sbjct: 112 DNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQ 171

Query: 180 TLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWT 239
           T V G  +A + ++ ++   R L+G ALAG ++  M L +EW+ +  R   G L    ++
Sbjct: 172 TAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYS 231

Query: 240 GGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHC 299
            G  LLA V Y +  WR L L V+ P     +  W+  ESARW  + G +    R L   
Sbjct: 232 LGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRV 291

Query: 300 ARLNGRPVCEDSFSQEAVSKVAAGERVVRR--PSYLDLFRTPRLRHISLCCVVVWFGVNF 357
           AR+NG+       S E +      E  + +   S ++L R P LRH+ LC  ++WF  +F
Sbjct: 292 ARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSF 351

Query: 358 SYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGT 417
           +YYGL +D+ G G+++Y  Q++FGAV+LP+KL+ +L +   GRR  Q   LL   +    
Sbjct: 352 AYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILL 411

Query: 418 RLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSL 477
             ++  D     T LAV+GK    A+F   +L+T ELYPT++R                 
Sbjct: 412 NGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR----------------- 454

Query: 478 APLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQEE 537
                                         +LLPET    LP+T+QD+E +    + Q++
Sbjct: 455 ---------------------------AVTVLLPETLGQPLPDTVQDLESRKGKQTRQQQ 487

Query: 538 E 538
           E
Sbjct: 488 E 488


>gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]
          Length = 553

 Score =  314 bits (804), Expect = 2e-85
 Identities = 200/544 (36%), Positives = 284/544 (52%), Gaps = 25/544 (4%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALP---GAPAN 57
           M F ELL+ VGG G FQ+     L +  + L    +L  F AAVP+HRC  P    + A 
Sbjct: 1   MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60

Query: 58  FS-----HQDVWLEAHLPREPDGTLSSCLRFAYPQAL---PNTTLGEERQSRGELEDEPA 109
            S       +  L   +P  P+     C RF  PQ     PN T             E  
Sbjct: 61  ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSW--------SEAD 112

Query: 110 TVPCSQGWEYDHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGR 169
           T PC  GW YD S F+STI  +W+LVC+   L   A + + AG+LVGA A G  SDRFGR
Sbjct: 113 TEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGR 172

Query: 170 RRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTV 229
           R +L  +Y+   V+G A+A + ++ ++ + R L   A+AG  +    L +EW     R +
Sbjct: 173 RLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPL 232

Query: 230 AGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHV 289
              L+S  ++ G  L A V Y +RDW  L L V++P     L  WW+ ESARWLLT G +
Sbjct: 233 VMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRL 292

Query: 290 KEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRP--SYLDLFRTPRLRHISLC 347
               + L   A +NG+   +D+ + E +      E  + +P  S   L R P LR  +  
Sbjct: 293 DWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCI 352

Query: 348 CVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGT 407
             + WF   F+++GL+LD+  LG N++  Q+  G V++P+K+   L + + GRR T A +
Sbjct: 353 STLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAAS 412

Query: 408 LLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLT 467
           LL   L      LV  +M +  + LAV+G     AAFT   +++SEL+PTVLR T +GL 
Sbjct: 413 LLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLG 472

Query: 468 ALVGRLGGSLAPLAALL--DGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDV 525
            +  R G  L PL  LL   G W  LP L YG + +L+   ALLLPET+   LP+TIQDV
Sbjct: 473 QMAARGGAILGPLVRLLGVHGPW--LPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDV 530

Query: 526 ERKS 529
           + ++
Sbjct: 531 QNQA 534


>gi|166064021 solute carrier family 22 (organic anion transporter),
           member 13 [Homo sapiens]
          Length = 551

 Score =  309 bits (791), Expect = 5e-84
 Identities = 190/533 (35%), Positives = 284/533 (53%), Gaps = 16/533 (3%)

Query: 3   FEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQD 62
           F ++L ++G FG FQ++ + LL +   L P +F   +F+     H CA+     +  +  
Sbjct: 4   FVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFNLS 63

Query: 63  V--WLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYD 120
               L   +P +  G    CL F  P A  N +L +    R        T PC  GWEY 
Sbjct: 64  AAEQLVLSVPLDTAGHPEPCLMFRPPPA--NASLQDILSHRFN-----ETQPCDMGWEYP 116

Query: 121 HSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVST 180
            +   S +  E++LVC++K L     + F AG+LVG + FG L DR GR+  +L   +  
Sbjct: 117 ENRLPS-LKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLF 175

Query: 181 LVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWTG 240
            ++GLA+A   S+ ++   R    +A+AG +   + L  EW+    RT A VL+   ++ 
Sbjct: 176 TLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSL 235

Query: 241 GVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHCA 300
           G M+LA + Y  R+WR L +  T P        W +PESARWLLT+G + EA + +   A
Sbjct: 236 GQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAA 295

Query: 301 RLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFSYY 360
            +N R +  +  +Q    K             LDLFR P+LR ++L    VWF  +  YY
Sbjct: 296 SVNRRKLSPELMNQLVPEKTGPSGNA------LDLFRHPQLRKVTLIIFCVWFVDSLGYY 349

Query: 361 GLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTRLL 420
           GLSL V   GL+VY TQL+FGAVE+P++      ++  GR+ +Q GTL+   L     + 
Sbjct: 350 GLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIF 409

Query: 421 VSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLAPL 480
           + +D+    T+LAV+GK  + AAFT +Y++++EL+PT+LRQTGMGL  +  R+GG L PL
Sbjct: 410 IPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPL 469

Query: 481 AALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTS 533
             LL     +LP L YG + ++A     LLPET    L +T+QD+E    P S
Sbjct: 470 VILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLELGPHPRS 522


>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
          Length = 550

 Score =  295 bits (756), Expect = 6e-80
 Identities = 187/540 (34%), Positives = 273/540 (50%), Gaps = 18/540 (3%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRC---ALPGAPAN 57
           M F +LLEQ GG G FQ   V    LP +++P   LL  F AA+P HRC    L    A 
Sbjct: 1   MAFSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAV 60

Query: 58  FSHQD--VWLEAHLPREPDGTLSSCLRFAYPQAL---PNTTLGEERQSRGELEDEPATVP 112
            ++      L   +P  P+     C RF  PQ     PN T             E  T P
Sbjct: 61  STNMTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATATSW--------SEADTEP 112

Query: 113 CSQGWEYDHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRL 172
           C  GW YD S F+STI  +WDLVC  +GL   + + F +G+LVG+  +G LS RFGR+ +
Sbjct: 113 CVDGWVYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPM 172

Query: 173 LLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGV 232
           L    +   V G ++  + ++V++   R +    +AG  +  + L +EW     R V   
Sbjct: 173 LSWCCLQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMT 232

Query: 233 LSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEA 292
           +    ++ G   L  + + +RDWR L LA ++P     L  WW+PESARWL+ +G   +A
Sbjct: 233 VVGCAFSAGQAALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQA 292

Query: 293 HRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRP-SYLDLFRTPRLRHISLCCVVV 351
            + L   AR+NG    ++   +  +S V       + P S LDLF  P LR  S   +VV
Sbjct: 293 LQELRKVARINGHKEAKNLTIEVLMSSVKEEVASAKEPRSVLDLFCVPVLRWRSCAMLVV 352

Query: 352 WFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGT 411
            F +  SYYGL  D+  LG +++  Q LFGAV+   +    L + + GRR  QAG+    
Sbjct: 353 NFSLLISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMA 412

Query: 412 ALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVG 471
            LA    +LV  D+++   V AV+GK     + T   ++ +EL+PT +R T  G+   VG
Sbjct: 413 GLAILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVG 472

Query: 472 RLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTAL-LLPETRQAQLPETIQDVERKSA 530
           RLG  + PL  +       LP L YG I++ ++   L  LPET+   LP+TIQD+E + +
Sbjct: 473 RLGAMMGPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDLESQKS 532


>gi|211059435 solute carrier family 22, member 24 [Homo sapiens]
          Length = 551

 Score =  291 bits (746), Expect = 8e-79
 Identities = 188/564 (33%), Positives = 278/564 (49%), Gaps = 33/564 (5%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALP-------- 52
           MGF+ LL+QVGG G FQ+  +A   +  +LL  + +L  F A  P+HRC +P        
Sbjct: 1   MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS 60

Query: 53  -GAPANFSHQDVWLEAHLPREPDGTLSSCLRFAYPQ--------ALPNTTLGEERQSRGE 103
                  S  D+ L   +P + +     C RF +PQ          PNT           
Sbjct: 61  DNDTGTLSKDDL-LRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNT----------- 108

Query: 104 LEDEPATVPCSQGWEYDHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYL 163
             +EP T PC  GW YD S F STI TEWDLVCE + L     + F AG L+G + +G+L
Sbjct: 109 --NEPDTEPCVDGWVYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHL 166

Query: 164 SDRFGRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLD 223
           SDR GR+ +  + ++   +    +A + +++++ I R L G +          L LEW  
Sbjct: 167 SDRVGRKIICKLCFLQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTL 226

Query: 224 VEHRTVAGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWL 283
              R++  ++    ++ G MLL  + + I+DW  L L V+ P     LS W + ESARWL
Sbjct: 227 PRSRSMTIMVLLCSYSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWL 286

Query: 284 LTQGHVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGE--RVVRRPSYLDLFRTPRL 341
           +    + E  + L   A +NG+   E++ + E V      E   V  + S   LFR P+L
Sbjct: 287 IINNQLDEGLKELRRVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKL 346

Query: 342 RHISLCCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRR 401
           R        V F +   +YGL L++  LG NV   Q+L GAV   ++ +  L++ + GRR
Sbjct: 347 RMRVFGLCFVRFAITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRR 406

Query: 402 LTQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQ 461
           ++Q        L       +  +M+    VLA +G     AA  +A +  +EL PT+LR 
Sbjct: 407 ISQILFTFPVGLFILVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRS 466

Query: 462 TGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPET 521
           T  G+ A+ GR G +LAPL   L      LP ++YG   +LA    LLLPETR   LP T
Sbjct: 467 TVAGINAVSGRTGAALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNT 526

Query: 522 IQDVERKSAPTSLQEEEMPMKQVQ 545
           IQDVE +    ++++E+  MK  Q
Sbjct: 527 IQDVENEKDSRNIKQEDTCMKVTQ 550


>gi|148664184 solute carrier family 22, member 10 [Homo sapiens]
          Length = 541

 Score =  265 bits (678), Expect = 6e-71
 Identities = 169/539 (31%), Positives = 264/539 (48%), Gaps = 17/539 (3%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCAL--------P 52
           M FEELL QVGG G FQ+ ++  +    +LL  H LL  F AA+P HRC +         
Sbjct: 1   MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS 60

Query: 53  GAPANFSHQDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVP 112
           G       +D  L   +P + +     C RF +PQ       G    +      E  T P
Sbjct: 61  GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHST-----SEADTEP 115

Query: 113 CSQGWEYDHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRL 172
           C  GW YD S F STI T+WDLVC+ + L          G+LVG +  G++SDRFGRR +
Sbjct: 116 CVDGWVYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFI 175

Query: 173 LLVAYVSTLVLGLASAASVSYVMFAITRTLTG-SALAGFTIIVMPLELEWLDVEHRTVAG 231
           L    +   +    +A + ++ ++ + R L G S++   +   +P+  EW+    + +  
Sbjct: 176 LRWCLLQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPIT-EWIRPNSKALVV 234

Query: 232 VLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKE 291
           +LSS   + G ++L  + Y+ RDW+ L +  ++P     L   W+ ESARWL+    + E
Sbjct: 235 ILSSGALSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDE 294

Query: 292 AHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGE--RVVRRPSYLDLFRTPRLRHISLCCV 349
             + L   AR NG    E++ + E V      E      + +  DLFR P +R      V
Sbjct: 295 GLKALRKVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILV 354

Query: 350 VVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLL 409
            + F     +YG  +++  +G N++  Q+L+GAV L  + L  L++ + GRR++Q   + 
Sbjct: 355 FLRFANTIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMF 414

Query: 410 GTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTAL 469
              L+      V  +M++    LA +G   S A F++  +   EL PTVLR    G+   
Sbjct: 415 LVGLSILANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLT 474

Query: 470 VGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERK 528
             R+G +LAPL   L   + +LP + YG   ++      LLPET+   LP+TI+DVE +
Sbjct: 475 ASRIGAALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQ 533


>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
          Length = 557

 Score =  263 bits (671), Expect = 4e-70
 Identities = 177/536 (33%), Positives = 267/536 (49%), Gaps = 24/536 (4%)

Query: 3   FEELLEQVGGFGPFQLRNVALLALPRVLLPLHF--LLPIFLAAVPAHRCALPGAPANFSH 60
           ++E+   +G +GPFQ   +    L   ++P  F  L  +FL A P HRC +P A AN S 
Sbjct: 4   YDEVTAFLGEWGPFQ--RLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDA-ANLS- 59

Query: 61  QDVWLEAHLP---REPDGTLSSCLRFAYPQALPNTTLGEERQ---SRGELEDEPATVPCS 114
              W    +P   R+      SC R+        + LG E       G+LE E     C 
Sbjct: 60  -SAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQES----CL 114

Query: 115 QGWEYDHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLL 174
            GWE+    + STI TEW+LVCE         + FF GVL+G+   G LSDRFGR+ +L 
Sbjct: 115 DGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLF 174

Query: 175 VAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLS 234
           V              S ++ MF +   L G       +    L  E L    R +   L 
Sbjct: 175 VTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLG 234

Query: 235 -STFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAH 293
              F+  G M+L L  Y IRDWR LL+A+T+P    +   W++PES RWL++QG  +EA 
Sbjct: 235 VCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAE 294

Query: 294 RYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWF 353
             +   A+ NG  V    F    +  +++ ++  +  + LDL RT  +R +++  +++W 
Sbjct: 295 VIIRKAAKANGIVVPSTIFDPSELQDLSSKKQ--QSHNILDLLRTWNIRMVTIMSIMLWM 352

Query: 354 GVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLL--GT 411
            ++  Y+GLSLD   L  +++    L   VE+P+ +L +L ++Y  RR + A  L   G+
Sbjct: 353 TISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGS 412

Query: 412 ALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVG 471
            L F    LV  D+   +TVL ++GK    AAF+  Y++T+ELYPTV+R  G+G+++   
Sbjct: 413 VLLF--MQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTAS 470

Query: 472 RLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVER 527
           RLG  L+P    L      LP +  G + +L A   L LPE+    LP+TI  + R
Sbjct: 471 RLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLR 526


>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
          Length = 556

 Score =  259 bits (661), Expect = 6e-69
 Identities = 176/545 (32%), Positives = 264/545 (48%), Gaps = 22/545 (4%)

Query: 3   FEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHR-CALPGAPA----- 56
           F+E L++VG FG FQ R   LL L  V     F+  +FL   P H  C  P A A     
Sbjct: 4   FDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERC 63

Query: 57  NFSHQDVW---LEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEP----A 109
            +S ++ W     A    EP      C R+    A  + +          L   P     
Sbjct: 64  GWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSAP 123

Query: 110 TVPCSQGWEYDHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGR 169
            VPC  GW Y  ++  STI +E+DLVC    +          G L GA   GY +DR+GR
Sbjct: 124 LVPCRGGWRY--AQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGR 181

Query: 170 RRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTV 229
             + L++ +   V G+  A + ++ +F I R L G    G  +    +  E +  + R +
Sbjct: 182 IVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRI 241

Query: 230 AGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHV 289
            G++   F+T G+++L  + Y I +W+ + LA+TLP    +L  W VPES RWL+T+   
Sbjct: 242 VGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKG 301

Query: 290 KEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCV 349
            +A + L   A+ NG+      +     S++   +  V  PS+LDL RTP++R  +L  +
Sbjct: 302 DKALQILRRIAKCNGK------YLSSNYSEITVTDEEVSNPSFLDLVRTPQMRKCTLILM 355

Query: 350 VVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLL 409
             WF     Y GL + +  +G N+Y    + G VELP  LL+ L++   GRRL  A + +
Sbjct: 356 FAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNI 415

Query: 410 GTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTAL 469
              +A      +   +    T +A +G+     AF   YL  SELYPT LR  G+ L + 
Sbjct: 416 VAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSG 475

Query: 470 VGRLGGSLAP-LAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERK 528
           +   GG +AP L   L  VWL LP + +G +A +  G  +LLPET+   LPET+ DVE+ 
Sbjct: 476 LCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKL 535

Query: 529 SAPTS 533
            +P S
Sbjct: 536 GSPHS 540


>gi|153791484 putative UST1-like organic anion transporter [Homo
           sapiens]
          Length = 547

 Score =  258 bits (659), Expect = 1e-68
 Identities = 171/546 (31%), Positives = 262/546 (47%), Gaps = 31/546 (5%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRC--------ALP 52
           M F++LL+QVGG G FQ+  +  L +  V++     L  F A +  HRC         +P
Sbjct: 1   MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP 60

Query: 53  GAPANFSHQDVWLEAHLPREPDGTLSSCLRFAYPQ--------ALPNTTLGEERQSRGEL 104
                   QD  L   +P + +     C RF +PQ          PNT+           
Sbjct: 61  DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTS----------- 109

Query: 105 EDEPATVPCSQGWEYDHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLS 164
             EP T PC  GW YD S F STI T+WDLVCE + LN  A   F AG++VG   +G+LS
Sbjct: 110 --EPDTEPCVDGWVYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLS 167

Query: 165 DRFGRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDV 224
           DRFGR+ +L  +Y+   ++G  +A + + +++   R L G+A     +  + L +EW+  
Sbjct: 168 DRFGRKFVLRWSYLQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITH 227

Query: 225 EHRTVAGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLL 284
           +   +A  L+    + G + L  + ++IRD   L L ++ PC    L   W+ ESARWL+
Sbjct: 228 QFCAMALTLTLCAASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLI 287

Query: 285 TQGHVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAG--ERVVRRPSYLDLFRTPRLR 342
                +E  + L   A  NG    ED  + E +        E   ++ S  +L R P + 
Sbjct: 288 INNKPEEGLKELRKAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNIC 347

Query: 343 HISLCCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRL 402
                   V F     ++GL+L +  LG NV+  Q LFGAV L +  +   ++ +  RRL
Sbjct: 348 KRICFLSFVRFASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRL 407

Query: 403 TQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQT 462
           +Q   +   A      + V  +M++   VLA +G   +    T +    +EL P+++R  
Sbjct: 408 SQMLLMFLLATCLLAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGR 467

Query: 463 GMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETI 522
             G+T     +GG+LA L  +L      LP + YG  A+L+    LLLPETR   L ++I
Sbjct: 468 ATGITGNFANIGGALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSI 527

Query: 523 QDVERK 528
           QDVE +
Sbjct: 528 QDVENE 533


>gi|42542386 solute carrier family 22 (organic anion/cation
           transporter), member 9 [Homo sapiens]
          Length = 553

 Score =  258 bits (658), Expect = 1e-68
 Identities = 178/567 (31%), Positives = 269/567 (47%), Gaps = 40/567 (7%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRC--------ALP 52
           M F++LL   G    FQ+     L++  V   LHF+L  F A +P HRC         + 
Sbjct: 1   MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVS 60

Query: 53  GAPANFSHQDVWLEAHLPREPDGTLSSCLRFAYPQ--------ALPNTTLGEERQSRGEL 104
                   QD  L   +P + +     C RF +PQ          PNT       S  ++
Sbjct: 61  DNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNT-------SDADM 113

Query: 105 EDEPATVPCSQGWEYDHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLS 164
           E      PC  GW YD   FSSTI TEWDLVC+ + L   A   F AG++VG +  G+LS
Sbjct: 114 E------PCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLS 167

Query: 165 DRFGRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDV 224
           DRFGRR +L   Y+   ++G  +A + +++++   R L+G A        + L  EW   
Sbjct: 168 DRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEW--A 225

Query: 225 EHRTVAGVLSSTFWTGGVMLLALVG--YLIRDWRWLLLAVTLPCAPGILSLWWVPESARW 282
            HR  A  ++      G+  + L G  + IRDW  L L V++P     L+  W+ ESARW
Sbjct: 226 THRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARW 285

Query: 283 LLTQGHVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVV---RRPSYLDLFRTP 339
           L+     +E  + L   A  +G     D+ + E +      E      ++PS  ++   P
Sbjct: 286 LIINNKPEEGLKELRKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMP 345

Query: 340 RL-RHISLCCVVVWFGVNF-SYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRY 397
            + + ISL     +   NF +Y+GL+L V  LG NV+  Q LFGAV L +  +   +++Y
Sbjct: 346 NICKRISLLSFTRF--ANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKY 403

Query: 398 AGRRLTQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPT 457
             RR +Q   +   A+     + V  +M++   VLA +G   S  A T A+   +E+ PT
Sbjct: 404 MNRRASQMLLMFLLAICLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPT 463

Query: 458 VLRQTGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQ 517
           ++R   MG+ A    + G+LAPL  +L      LP + YG    ++    LLLPETR   
Sbjct: 464 IIRARAMGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKP 523

Query: 518 LPETIQDVERKSAPTSLQEEEMPMKQV 544
           L +TIQD + +       ++E P  +V
Sbjct: 524 LFDTIQDEKNERKDPREPKQEDPRVEV 550


>gi|31542327 solute carrier family 22, member 16 [Homo sapiens]
          Length = 577

 Score =  257 bits (657), Expect = 2e-68
 Identities = 168/539 (31%), Positives = 266/539 (49%), Gaps = 17/539 (3%)

Query: 3   FEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQD 62
           FE + + VG FG FQ     + A   +   +H+L  +F+   P H C  PG   N S   
Sbjct: 6   FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPG---NVSQVV 62

Query: 63  VWLEAHLPREPDGTLSSCLRFAYPQA-LPNTTLGE-ERQSRGELEDEPAT---------- 110
               ++   E  G L S  +  Y    L N  + E  R SR + E+  +           
Sbjct: 63  FHNHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKE 122

Query: 111 VPCSQGWEYDHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRR 170
            PC  G+ YD + + ST  T+W+LVC++K L       F  GVL+G+V FGY SDR GRR
Sbjct: 123 FPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRR 182

Query: 171 RLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVA 230
            +L     S  + G+A+A +V Y  F   R       +G+ ++     +E++ ++ RT A
Sbjct: 183 VVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWA 242

Query: 231 GVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVK 290
            V   +F+  G +L+AL GYL+R W    + ++    P IL  W +PE+  WLL++G  +
Sbjct: 243 SVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYE 302

Query: 291 EAHRYLLHCARLNGRPVCE--DSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCC 348
           EA + +   A+ N    C+  +  S +    V+     V++ +   LF    +   +L  
Sbjct: 303 EAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTV 362

Query: 349 VVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTL 408
            ++WF  +  +Y  SL+   LG N Y    L G VE+P+   V +++   GRR   A +L
Sbjct: 363 WLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSL 422

Query: 409 LGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTA 468
             +ALA G  +++         V A++GK    AAF   YL+T+ELYPT++R   +G  +
Sbjct: 423 FCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGS 482

Query: 469 LVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVER 527
           +V RL   LAP +  L  +W+ +P+L  G +ALL+    L LPET   +L  T ++  +
Sbjct: 483 MVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAAK 541


>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
          Length = 551

 Score =  246 bits (627), Expect = 5e-65
 Identities = 177/559 (31%), Positives = 266/559 (47%), Gaps = 39/559 (6%)

Query: 3   FEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQD 62
           ++E++  +G +GPFQ     LL+   +    + +  +FLA  P HRC +P A AN S   
Sbjct: 4   YDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDA-ANLS--S 60

Query: 63  VWLEAHLP---REPDGTLSSCLRFAYPQALPNTTLGEERQ---SRGELEDEPATVPCSQG 116
            W    +P   R+      SC R+        + LG E       G+LE E     C  G
Sbjct: 61  AWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQES----CLDG 116

Query: 117 WEYDHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVA 176
           WE+    + ST+ TEW+LVCE        ++ FF GVL+G+   G LSDRFGR+ +L   
Sbjct: 117 WEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFAT 176

Query: 177 YVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLS-S 235
                        S+S+ MF +   + G       ++   L  E L    R +   L   
Sbjct: 177 MAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVC 236

Query: 236 TFWTGGVMLLALVGYLIRDWRWLLLAVTLP---CAPGILSLWW-VPESARWLLTQGHVKE 291
           TF+  G MLL L  Y IRDWR LLLA+T+P   C P    LWW +PES RWL++Q   +E
Sbjct: 237 TFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVP----LWWFIPESPRWLISQRRFRE 292

Query: 292 AHRYLLHCARLNGRPVCEDSF-SQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVV 350
           A   +   A++N   V    F S E ++ +   +  +     LDLFRT  +  +++  ++
Sbjct: 293 AEDIIQKAAKMNNIAVPAVIFDSVEELNPLKQQKAFI-----LDLFRTRNIAIMTIMSLL 347

Query: 351 VWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLL- 409
           +W   +  Y+ LSLD   L  + Y    L   +E+P+ +  +L +R   RR   A  L  
Sbjct: 348 LWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFW 407

Query: 410 -GTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTA 468
            G  L F    LV  D    S  L ++GK    +AF+  Y+FT+ELYPT++R   +G+T+
Sbjct: 408 GGGVLLF--IQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTS 465

Query: 469 LVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVER- 527
              R+G  +AP    L      LP +  G + +L     L  PE+    LPET++ +++ 
Sbjct: 466 TASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKV 525

Query: 528 ------KSAPTSLQEEEMP 540
                 K    S++ EE P
Sbjct: 526 KWFRSGKKTRDSMETEENP 544


>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
          Length = 547

 Score =  242 bits (617), Expect = 7e-64
 Identities = 183/539 (33%), Positives = 267/539 (49%), Gaps = 55/539 (10%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60
           M  EE  + VG  G +Q+    LLA   VLL L+        A  A   AL GA  ++ H
Sbjct: 1   MEVEEAFQAVGEMGIYQMYLCFLLA---VLLQLY-------VATEAILIALVGATPSY-H 49

Query: 61  QDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWE-Y 119
            D+                       + LPN + G   QS GE +     +  + G E +
Sbjct: 50  WDL----------------------AELLPNQSHGN--QSAGEDQAFGDWLLTANGSEIH 85

Query: 120 DHSEFSST---IATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVA 176
            H  FSS+   IA+EW L+  +     AAS+FFF+GV VG ++FG LSDRFGR+++ L  
Sbjct: 86  KHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTG 145

Query: 177 YVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSST 236
           +   ++  +A+  S SY  FA+TR L G    G +++   L  E +   +  +AG +   
Sbjct: 146 FALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGL 205

Query: 237 FWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYL 296
           F+  G+   AL+GY IR WR L + V L      L   ++PES RWL +QG + EA   L
Sbjct: 206 FFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEAL 265

Query: 297 LHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRP-SYLDLFRTPRLRHISLCCVVVWFGV 355
              A+ N +  C  S +  A        R  R   S+LDLFR   L   +L  + +WF  
Sbjct: 266 YLIAKRNRKLKCTFSLTHPA-------NRSCRETGSFLDLFRYRVLLGHTLILMFIWFVC 318

Query: 356 NFSYYGLSLDVSGLGLNVYQTQLLFGAVELPS-KLLVYL-SVRYAGRRLTQAGTLL--GT 411
           +  YYGL+L    LG ++Y    L G +E+PS  L +YL + ++ GR+ T +  L   G 
Sbjct: 319 SLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGL 378

Query: 412 ALAFGTRLLVSSDMKSWSTV----LAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLT 467
           A      L    D   ++ V    L+++GK    AAF   Y++TSELYPTV+R  G+G  
Sbjct: 379 ACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTC 438

Query: 468 ALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVE 526
           ++  R+GG +AP    L  V  SLP + +G   L +   +LLLPET  + L ET  D++
Sbjct: 439 SMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQ 497


>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
          Length = 555

 Score =  234 bits (597), Expect = 2e-61
 Identities = 163/551 (29%), Positives = 259/551 (47%), Gaps = 17/551 (3%)

Query: 4   EELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQDV 63
           +++LE  G F  FQ +   LLAL        ++  +FL   P HRC  PG  A  S +  
Sbjct: 6   DDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGV-AELSLRCG 64

Query: 64  WLEAH-----LPRE-PDGTLS--SCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQ 115
           W  A      +P   P G  S   C R+            +   S           PC  
Sbjct: 65  WSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCRD 124

Query: 116 GWEYDHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLV 175
           GW Y+     S+I TE++LVC    +     +    G  +G+++ GY++DRFGR+  LL 
Sbjct: 125 GWVYETP--GSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLT 182

Query: 176 AYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSS 235
             +     G+  A S +Y    I R + G       +I   L  E++   +R   G+   
Sbjct: 183 TVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQ 242

Query: 236 TFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRY 295
             +T G+++LA V Y +  WRWL   V LP    +L  W +PES RWL++Q    EA R 
Sbjct: 243 VAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAMRI 302

Query: 296 LLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGV 355
           + H A+ NG+ +   +  Q    +   G+++   PS+LDL RTP++R  ++  +  WF  
Sbjct: 303 IKHIAKKNGKSL--PASLQRLRLEEETGKKL--NPSFLDLVRTPQIRKHTMILMYNWFTS 358

Query: 356 NFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAF 415
           +  Y GL + +   G N+Y        VE P+  ++ L++   GRR   A + +    A 
Sbjct: 359 SVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAAC 418

Query: 416 GTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGG 475
              + +  D++    +++ +G+     A+    L  +ELYPT +R  G+ + + +  +GG
Sbjct: 419 LASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGG 478

Query: 476 SLAP-LAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSL 534
            + P L   L  +WL LP + +G + L+A G  LLLPET+   LPETI++ E    P   
Sbjct: 479 IITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRK- 537

Query: 535 QEEEMPMKQVQ 545
            +E+M   QVQ
Sbjct: 538 NKEKMIYLQVQ 548


>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
           sapiens]
          Length = 554

 Score =  226 bits (577), Expect = 3e-59
 Identities = 167/549 (30%), Positives = 252/549 (45%), Gaps = 37/549 (6%)

Query: 4   EELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQDV 63
           +++LEQVG  G FQ +   +L L         +  +FL   P H C  PG  A  S +  
Sbjct: 5   DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGV-AELSQRCG 63

Query: 64  WLEAH--------LPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQ 115
           W  A         L    +  L  C R+         +  +   S           PC  
Sbjct: 64  WSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQD 123

Query: 116 GWEYDHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLV 175
           GW YD     S+I TE++LVC          +   AG L G++  GY +DRFGR+  LL 
Sbjct: 124 GWVYDTP--GSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLG 181

Query: 176 AYVSTLVLGLASAASVSYVMFAITRTLTGSA-----LAGFTIIVMPLELEWLDVEHRTVA 230
             +   V G+  A S +Y+   + R L G       +AG+T+I      E++    R   
Sbjct: 182 TVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLIT-----EFVGSGSRRTV 236

Query: 231 GVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVK 290
            ++    +T G++ L  + Y +  WRWL LAV+LP    +L  W VPES RWLL+Q    
Sbjct: 237 AIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNT 296

Query: 291 EAHRYLLHCARLNGRPVCED----SFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISL 346
           EA + + H A+ NG+    D    S  ++   K++        PS+ DLFRTPRLR  + 
Sbjct: 297 EAIKIMDHIAQKNGKLPPADLKMLSLEEDVTEKLS--------PSFADLFRTPRLRKRTF 348

Query: 347 CCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAG 406
             + +WF  +  Y GL L +     N+Y   L    VE+P   +  +++   GR    A 
Sbjct: 349 ILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAM 408

Query: 407 TLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGL 466
           + L    A    + +S D+   + ++  +G+     A     L  +ELYPT +R  G+ +
Sbjct: 409 SNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMV 468

Query: 467 TALVGRLGGSLAPLAAL-LDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDV 525
            + +  +GG + P     L  VW +LP + +  + LLAAG  LLLPET+   LPET++D 
Sbjct: 469 CSSLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDA 528

Query: 526 E---RKSAP 531
           E   RK+ P
Sbjct: 529 ENLGRKAKP 537


>gi|157426885 organic cation transporter like 4 [Homo sapiens]
          Length = 594

 Score =  205 bits (522), Expect = 8e-53
 Identities = 157/539 (29%), Positives = 260/539 (48%), Gaps = 38/539 (7%)

Query: 3   FEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH-- 60
           F  LL+ VG FG FQ R VAL  +P ++         F+       C      A   H  
Sbjct: 52  FANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPHLS 111

Query: 61  QDVWLEAHLPREPDGTLSSCLRFA-YPQALPNTTLGEERQSRGELEDEPATVPCSQGWEY 119
           +   L   +P+ P+G+  +C  +   P  L +         +  L D   T  C  GW Y
Sbjct: 112 KAEQLNLTIPQAPNGSFLTCFMYLPVPWNLDSII-------QFGLND---TDTCQDGWIY 161

Query: 120 DHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVS 179
             ++  S I  E+DLVC  +     A   F AG+ +G++ F  ++D+ GR   +L++ + 
Sbjct: 162 PDAKKRSLI-NEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLG 220

Query: 180 TLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWT 239
            ++ G  +A   S+ ++   R     ++ G+ I  + L  EWL  EHR  A +L   F+ 
Sbjct: 221 LIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFA 280

Query: 240 GGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHC 299
            G +LL  + Y +  W+ L L   +   P I  +W +PES RWL+ +G VKEA + L + 
Sbjct: 281 VGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYA 340

Query: 300 ARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFSY 359
           A +N + +         + ++    + V R S LD  +  +L  ++L    VWF V+++Y
Sbjct: 341 ASVNKKTI-----PSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTY 395

Query: 360 YGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTAL------ 413
           + LSL +  LG++V+   ++   +E+P++L     ++  GR+ + A TLL   +      
Sbjct: 396 FTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLL 455

Query: 414 -----AFGTRL----LVSSDMKSWSTVLAVMGKAFSEAAFTTA-YLFTSELYPTVLRQTG 463
                  G RL      ++++KS  T+L +M + FS AA  T  +L+T+EL PTVLR TG
Sbjct: 456 FLPEGEDGLRLKWPRCPATELKS-MTILVLMLREFSLAATVTVFFLYTAELLPTVLRATG 514

Query: 464 MGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETI 522
           +GL +L    G  L+    ++      LP      +A++A   + LLPETR   L E++
Sbjct: 515 LGLVSLASVAGAILS--LTIISQTPSLLPIFLCCVLAIVAFSLSSLLPETRDQPLSESL 571


>gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]
          Length = 332

 Score =  197 bits (500), Expect = 3e-50
 Identities = 118/315 (37%), Positives = 172/315 (54%), Gaps = 6/315 (1%)

Query: 219 LEWLDVEHRTVAGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPE 278
           +EW     R +   L+S  ++ G  L A V Y +RDW  L L V++P     L  WW+ E
Sbjct: 1   MEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAE 60

Query: 279 SARWLLTQGHVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRP--SYLDLF 336
           SARWLLT G +    + L   A +NG+   +D+ + E +      E  + +P  S   L 
Sbjct: 61  SARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLL 120

Query: 337 RTPRLRHISLCCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVR 396
           R P LR  +    + WF   F+++GL+LD+  LG N++  Q+  G V++P+K+   L + 
Sbjct: 121 RMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLS 180

Query: 397 YAGRRLTQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYP 456
           + GRR T A +LL   L      LV  +M +  + LAV+G     AAFT   +++SEL+P
Sbjct: 181 HLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFP 240

Query: 457 TVLRQTGMGLTALVGRLGGSLAPLAALL--DGVWLSLPKLTYGGIALLAAGTALLLPETR 514
           TVLR T +GL  +  R G  L PL  LL   G W  LP L YG + +L+   ALLLPET+
Sbjct: 241 TVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPW--LPLLVYGTVPVLSGLAALLLPETQ 298

Query: 515 QAQLPETIQDVERKS 529
              LP+TIQDV+ ++
Sbjct: 299 SLPLPDTIQDVQNQA 313


>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
           sapiens]
          Length = 506

 Score =  180 bits (456), Expect = 3e-45
 Identities = 138/477 (28%), Positives = 209/477 (43%), Gaps = 33/477 (6%)

Query: 4   EELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQDV 63
           +++LEQVG  G FQ +   +L L         +  +FL   P H C  PG  A  S +  
Sbjct: 5   DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGV-AELSQRCG 63

Query: 64  WLEAH--------LPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQ 115
           W  A         L    +  L  C R+         +  +   S           PC  
Sbjct: 64  WSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQD 123

Query: 116 GWEYDHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLV 175
           GW YD     S+I TE++LVC          +   AG L G++  GY +DRFGR+  LL 
Sbjct: 124 GWVYDTP--GSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLG 181

Query: 176 AYVSTLVLGLASAASVSYVMFAITRTLTGSA-----LAGFTIIVMPLELEWLDVEHRTVA 230
             +   V G+  A S +Y+   + R L G       +AG+T+I      E++    R   
Sbjct: 182 TVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLIT-----EFVGSGSRRTV 236

Query: 231 GVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVK 290
            ++    +T G++ L  + Y +  WRWL LAV+LP    +L  W VPES RWLL+Q    
Sbjct: 237 AIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNT 296

Query: 291 EAHRYLLHCARLNGRPVCED----SFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISL 346
           EA + + H A+ NG+    D    S  ++   K++        PS+ DLFRTPRLR  + 
Sbjct: 297 EAIKIMDHIAQKNGKLPPADLKMLSLEEDVTEKLS--------PSFADLFRTPRLRKRTF 348

Query: 347 CCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAG 406
             + +WF  +  Y GL L +     N+Y   L    VE+P   +  +++   GR    A 
Sbjct: 349 ILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAM 408

Query: 407 TLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTG 463
           + L    A    + +S D+   + ++  +G+     A     L  +ELYPT +   G
Sbjct: 409 SNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVSGVG 465


>gi|213021148 SVOP-like isoform 1 [Homo sapiens]
          Length = 492

 Score =  138 bits (347), Expect = 1e-32
 Identities = 115/436 (26%), Positives = 206/436 (47%), Gaps = 57/436 (13%)

Query: 125 SSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLG 184
           S  I  EW L   Q  L    +T  F G +V ++ FG L+DR+GR ++LL++++      
Sbjct: 72  SPVIRCEWQLENWQVAL---VTTMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFS 128

Query: 185 LASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFW-TGGVM 243
           L ++ + SY+ F   RT+ G  ++G +  ++ ++ E+L  ++R     LS  FW  G ++
Sbjct: 129 LLTSFAPSYIWFVFLRTMVGCGVSGHSQGLI-IKTEFLPTKYRGYMLPLSQVFWLAGSLL 187

Query: 244 LLALVGYLIR--DWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHCAR 301
           ++ L   +I    WRWL+   ++P    I++  ++PESAR+ ++ G+ + A   L   A+
Sbjct: 188 IIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAK 247

Query: 302 LNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFSYYG 361
           +N   + E    +  + K         R  + DL     LR  +L   V+W G++F+YYG
Sbjct: 248 MNRSVMPEGKLVEPVLEK---------RGRFADLLDAKYLR-TTLQIWVIWLGISFAYYG 297

Query: 362 LSLDVSGL----------------------------------GLNVYQTQLLFGAVELPS 387
           + L  + L                                    + Y+T ++    E+  
Sbjct: 298 VILASAELLERDLVCGSKSDSAVVVTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIAL 357

Query: 388 KLLVYLSVRYAGRRLTQAGTLLGTALAFGTRLLVSSDMKSWSTV-LAVMGKAFSEAAFTT 446
             L  L + + GRRL+ + T+  TAL F   LL++    S   +    M +A   A F T
Sbjct: 358 NPLNILGINFLGRRLSLSITMGCTALFF---LLLNICTSSAGLIGFLFMLRALVAANFNT 414

Query: 447 AYLFTSELYPTVLRQTGMGLTALVGRLGGSLAP-LAALLDGVWLSLPKLTYGGIALLAAG 505
            Y++T+E+YPT +R  GMG +  + R+G  +AP ++ +L    +      +  + ++ A 
Sbjct: 415 VYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAI 474

Query: 506 TALLLP-ETRQAQLPE 520
           +A  LP ET+   L +
Sbjct: 475 SAFTLPIETKGRALQQ 490


>gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1
           [Homo sapiens]
          Length = 558

 Score =  136 bits (342), Expect = 6e-32
 Identities = 122/413 (29%), Positives = 185/413 (44%), Gaps = 24/413 (5%)

Query: 132 WDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAASV 191
           W+LVC               G L+G V  G   DRFGRR + + + V T  LG + A + 
Sbjct: 119 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 178

Query: 192 SYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWTGGVMLLALVGYL 251
           S+    + R L G  LAG  + +    LE  D  HR    + +  F   G +LL  +  L
Sbjct: 179 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 238

Query: 252 IRDWRWLLLAVTLPCAPGILSLWW-----VPESARWLLTQGHVKEAHRYLLHCARLNGRP 306
           ++DWR  LL        G+L L+W      PES  WLL  G V  A + L   A  +G  
Sbjct: 239 VQDWR--LLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVG 296

Query: 307 VCEDSFSQEAVSK------VAAGERVVRRPSYLDLFRTPRLRHISLCC---VVVWFGVNF 357
             + S  + +++       ++A     R  S L L RT       L      +V  G+  
Sbjct: 297 PGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRA 356

Query: 358 SYY-GLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRR-LTQAGTLLGTALAF 415
           S+   L+  V       Y    L   +E  + + + L+    GRR +   GT++ T LA 
Sbjct: 357 SFRRSLAPQVP----TFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMV-TGLAS 411

Query: 416 GTRLLVSSDMKSWSTV-LAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLG 474
              L  +  +  W+ + L+V+G   S A    + LF +E++PTV+R  G+GL    G LG
Sbjct: 412 LLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLG 471

Query: 475 GSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVER 527
            +  PL  L       L ++ +  +A+LA    LLLPE+R   LP+++QD +R
Sbjct: 472 QAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADR 524


>gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6
           [Homo sapiens]
          Length = 560

 Score =  133 bits (335), Expect = 4e-31
 Identities = 152/547 (27%), Positives = 224/547 (40%), Gaps = 52/547 (9%)

Query: 6   LLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCA-----LPGAPANFSH 60
           +L   GGFG  +    +   +P ++L L       L A PA  C      LP A      
Sbjct: 7   VLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA-LRALR 65

Query: 61  QDVWLEAHLPR-EPDGTLSSCLRFAY--PQALPNTTLGEERQSRGELEDEPATVPCSQGW 117
               L+A +PR  P    S CL      P  L   T                  P    W
Sbjct: 66  GPALLDAAIPRLGPTRAASPCLPLGVLSPSYLAPLT----------------RAPRPSSW 109

Query: 118 EYDHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAY 177
               S   +     W+LVC               G L+G V  G   DRFGRR + + + 
Sbjct: 110 A---SCSGAAAGPTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASL 166

Query: 178 VSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTF 237
           V T  LG + A + S+    + R L G  LAG  + +    LE  D  HR    + +  F
Sbjct: 167 VLTTGLGASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLF 226

Query: 238 WTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWW-----VPESARWLLTQGHVKEA 292
              G +LL  +  L++DWR  LL        G+L L+W      PES  WLL  G V  A
Sbjct: 227 SVVGTLLLPGLAALVQDWR--LLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARA 284

Query: 293 HRYLLHCARLNGRPVCEDSFSQEA------VSKVAAGERVVRRPSYLDLFRTP---RLRH 343
            + L   A  +G    + S  + +      ++ ++A     R  S L L RT    R   
Sbjct: 285 RKILWRFAEASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGL 344

Query: 344 ISLCCVVVWFGVNFSY-YGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRR- 401
           I     +V  G+  S+   L+  V       Y    L   +E  + + + L+    GRR 
Sbjct: 345 ILGFSSLVGGGIRASFRRSLAPQVP----TFYLPYFLEAGLEAAALVFLLLTADCCGRRP 400

Query: 402 LTQAGTLLGTALAFGTRLLVSSDMKSWSTV-LAVMGKAFSEAAFTTAYLFTSELYPTVLR 460
           +   GT++ T LA    L  +  +  W+ + L+V+G   S A    + LF +E++PTV+R
Sbjct: 401 VLLLGTMV-TGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIR 459

Query: 461 QTGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPE 520
             G+GL    G LG +   L  L       L ++ +  +A+LA    LLLPE+R   LP+
Sbjct: 460 GAGLGLVLGAGFLGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQ 519

Query: 521 TIQDVER 527
           ++QD +R
Sbjct: 520 SLQDADR 526


>gi|24308167 SV2 related protein [Homo sapiens]
          Length = 548

 Score =  130 bits (328), Expect = 2e-30
 Identities = 121/425 (28%), Positives = 185/425 (43%), Gaps = 52/425 (12%)

Query: 131 EWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAAS 190
           EW L   Q  L    ++  F G++  +  +G +SD++GR+  L ++ + TL  G+ SA +
Sbjct: 114 EWRLPSWQVAL---LTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFA 170

Query: 191 VSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWTGGVMLLALVGY 250
             Y    + R L G  + G    V  L  E+L ++ R    +L   FW  G +   ++  
Sbjct: 171 PVYSWILVLRGLVGFGIGGVPQSVT-LYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAV 229

Query: 251 LIRD---WRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHCARLNGRPV 307
            +     WRWLL+   +P     +  +W+PESAR+ +  G+ ++A   L   A  NG P+
Sbjct: 230 FVMPSLGWRWLLILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENGAPM 289

Query: 308 CEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFSYYGLSL--- 364
                    + K+    R   R    DLF TP  R  +L    +WF   FSYYGL L   
Sbjct: 290 --------PLGKLIIS-RQEDRGKMRDLF-TPHFRWTTLLLWFIWFSNAFSYYGLVLLTT 339

Query: 365 ------DVSGLGLNV------------------YQTQLLFGAVELPSKLLVYLSVRYAGR 400
                 DV G+                      Y   L     E P  L+    +   GR
Sbjct: 340 ELFQAGDVCGISSRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGR 399

Query: 401 RLTQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLR 460
           + T A  L     +F + LL     ++  T+L  + +AF    F  AY++T E+YPT  R
Sbjct: 400 KKTMA--LCFVIFSFCSLLLFICVGRNVLTLLLFIARAFISGGFQAAYVYTPEVYPTATR 457

Query: 461 QTGMGLTALVGRLGGSLAPLAA---LLDGVWLSLPKLTYGGIALLAAGTALLLP-ETRQA 516
             G+G  + + R+G  + P  A   L   V+L+L    Y G  LLAA  +  LP ET+  
Sbjct: 458 ALGLGTCSGMARVGALITPFIAQVMLESSVYLTL--AVYSGCCLLAALASCFLPIETKGR 515

Query: 517 QLPET 521
            L E+
Sbjct: 516 GLQES 520


>gi|63999576 solute carrier family 22, member 17 isoform b [Homo
           sapiens]
          Length = 520

 Score =  124 bits (311), Expect = 2e-28
 Identities = 121/441 (27%), Positives = 192/441 (43%), Gaps = 26/441 (5%)

Query: 113 CSQGWEYDHSEFSSTIAT-EWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRR 171
           C + W+Y+     +T A  +WDLVC+           F  G   G +  GY +DRFGRR 
Sbjct: 70  CLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRG 129

Query: 172 LLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAG 231
           ++L+        G+  AA+ S       R L G  LAG  + V  + LE  D   R    
Sbjct: 130 IVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVA 189

Query: 232 VLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLW--WVPESARWLLTQGHV 289
           +       GG  L   +  + +DWR+L   +T PC   +   W     ESARWL+ +  +
Sbjct: 190 LAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKRQI 249

Query: 290 KEAH---RYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISL 346
           +EA    R L    R +G+ + E+  +QEA+  +   E     P+         L + ++
Sbjct: 250 EEAQSVLRILAERNRPHGQMLGEE--AQEALQDL---ENTCPLPATSSFSFASLLNYRNI 304

Query: 347 CCVVVWFG-VNFSYYGL-----SLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGR 400
              ++  G  NF  + +      +   G   + Y   LL       + + + ++V   GR
Sbjct: 305 WKNLLILGFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGR 364

Query: 401 RLTQAGTLLGTALAFGTRLLVSSDM-----KSWSTVLAVMGKAFSEAAFTTAYLFTSELY 455
           R    G LL +    G   LV   +     ++  T  +V+G   S+AA   + L  +E+ 
Sbjct: 365 R----GILLLSMTLTGIASLVLLGLWDYLNEAAITTFSVLGLFSSQAAAILSTLLAAEVI 420

Query: 456 PTVLRQTGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQ 515
           PT +R  G+GL   +G LGG   P   L  G    L  +     ALL   + +LLPET++
Sbjct: 421 PTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKR 480

Query: 516 AQLPETIQDVERKSAPTSLQE 536
             LPE ++D E    P+ L++
Sbjct: 481 KLLPEVLRDGELCRRPSLLRQ 501


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.137    0.422 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,150,847
Number of Sequences: 37866
Number of extensions: 906421
Number of successful extensions: 2281
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 49
Number of HSP's successfully gapped in prelim test: 29
Number of HSP's that attempted gapping in prelim test: 2093
Number of HSP's gapped (non-prelim): 96
length of query: 546
length of database: 18,247,518
effective HSP length: 107
effective length of query: 439
effective length of database: 14,195,856
effective search space: 6231980784
effective search space used: 6231980784
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.