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Search of human proteins with 239758013
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239758013 PREDICTED: hypothetical protein [Homo sapiens]
(819 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239758013 PREDICTED: hypothetical protein [Homo sapiens] 1626 0.0
gi|239758117 PREDICTED: hypothetical protein [Homo sapiens] 147 5e-35
gi|239758008 PREDICTED: hypothetical protein XP_002346266 [Homo ... 135 2e-31
gi|239753329 PREDICTED: hypothetical protein XP_002345623 [Homo ... 127 4e-29
gi|239758151 PREDICTED: hypothetical protein XP_002346314 [Homo ... 122 1e-27
gi|239741651 PREDICTED: hypothetical protein XP_002342270 [Homo ... 115 2e-25
gi|57864582 hornerin [Homo sapiens] 103 6e-22
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 98 4e-20
gi|60097902 filaggrin [Homo sapiens] 96 1e-19
gi|158854042 hypothetical protein LOC222183 [Homo sapiens] 92 3e-18
gi|239756562 PREDICTED: hypothetical protein [Homo sapiens] 89 1e-17
gi|239754474 PREDICTED: similar to mucin [Homo sapiens] 88 3e-17
gi|239752579 PREDICTED: hypothetical protein XP_002348295 [Homo ... 88 4e-17
gi|239752632 PREDICTED: hypothetical protein XP_002347697 [Homo ... 86 2e-16
gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens] 84 4e-16
gi|239754599 PREDICTED: hypothetical protein [Homo sapiens] 82 2e-15
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens] 80 6e-15
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 77 6e-14
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 77 6e-14
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 77 6e-14
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 77 6e-14
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens] 76 1e-13
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens] 76 1e-13
gi|62122917 filaggrin family member 2 [Homo sapiens] 74 4e-13
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 73 9e-13
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 72 3e-12
gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens] 71 5e-12
gi|239757861 PREDICTED: similar to armadillo repeat containing, ... 70 1e-11
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 70 1e-11
gi|239750574 PREDICTED: hypothetical protein [Homo sapiens] 69 1e-11
>gi|239758013 PREDICTED: hypothetical protein [Homo sapiens]
Length = 819
Score = 1626 bits (4210), Expect = 0.0
Identities = 819/819 (100%), Positives = 819/819 (100%)
Query: 1 MDYRGHRQCNQAAGRAGPGAPLGAALARTPVELAAESAAPALSAAAAGVKILGSGDKKLR 60
MDYRGHRQCNQAAGRAGPGAPLGAALARTPVELAAESAAPALSAAAAGVKILGSGDKKLR
Sbjct: 1 MDYRGHRQCNQAAGRAGPGAPLGAALARTPVELAAESAAPALSAAAAGVKILGSGDKKLR 60
Query: 61 RQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRG 120
RQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRG
Sbjct: 61 RQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRG 120
Query: 121 RKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAA 180
RKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAA
Sbjct: 121 RKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAA 180
Query: 181 GAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRG 240
GAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRG
Sbjct: 181 GAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRG 240
Query: 241 GGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAA 300
GGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAA
Sbjct: 241 GGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAA 300
Query: 301 KGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKK 360
KGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKK
Sbjct: 301 KGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKK 360
Query: 361 QRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPR 420
QRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPR
Sbjct: 361 QRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPR 420
Query: 421 GGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKAS 480
GGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKAS
Sbjct: 421 GGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKAS 480
Query: 481 AAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRV 540
AAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRV
Sbjct: 481 AAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRV 540
Query: 541 GGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKA 600
GGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKA
Sbjct: 541 GGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKA 600
Query: 601 AAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQ 660
AAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQ
Sbjct: 601 AAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQ 660
Query: 661 PRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRL 720
PRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRL
Sbjct: 661 PRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRL 720
Query: 721 GKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKA 780
GKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKA
Sbjct: 721 GKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKA 780
Query: 781 VTAGGQKAAAAGGKKPPRVKSRGGRGQKAAAGGKKPLRR 819
VTAGGQKAAAAGGKKPPRVKSRGGRGQKAAAGGKKPLRR
Sbjct: 781 VTAGGQKAAAAGGKKPPRVKSRGGRGQKAAAGGKKPLRR 819
>gi|239758117 PREDICTED: hypothetical protein [Homo sapiens]
Length = 465
Score = 147 bits (370), Expect = 5e-35
Identities = 126/326 (38%), Positives = 159/326 (48%), Gaps = 72/326 (22%)
Query: 153 RGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRS------GKKPRRRGAKSRGDEDK--- 203
R + A A + +G + + AA A+ +S GK+P + + +R D +
Sbjct: 68 RDSRVTPATALLLLSHRGRAQRRSIQAAAAQEQSTGRGCLGKEPPSQESWTRSDPRRCLS 127
Query: 204 ----KGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAAT-G 258
+ R +SR +TRGG K+ RR K A GAKSR G GKKPQ RRGQKAAT G
Sbjct: 128 QDAVRSGSRVCRSR-PQTRGGGGKQPRRQKAAVAGAKSRGGEGKKPQ---RRGQKAATAG 183
Query: 259 GKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRW 318
KSR G R G KK+RR GQ A AGAKR G
Sbjct: 184 AKSRGGGVRSLGGKKMRR-GQKGA-AGAKRCG---------------------------- 213
Query: 319 GRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGA 378
GGK+PRRRGQKA+K+ + QKAA GVKSRKK R+RG+K AA
Sbjct: 214 --GGKQPRRRGQKASKSGGVRCQT----PQKAAAQGVKSRKKLRQRGQKAAAAGQEAAAG 267
Query: 379 KSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRR-------RG 431
K+ GGG + K RG G KKP +N R R QKA AA G KKP++ R
Sbjct: 268 KTCGGGGE------KHRGGGDKKPLRKNSRWRGQKAAAA-----GGKKPQKAAAAGGERR 316
Query: 432 PKAAKSRGGKSRSGGGKKPRRRGQKA 457
K + + +R+ KKPR RGQ +
Sbjct: 317 KKLRRQKAAVARAKSPKKPRWRGQNS 342
Score = 127 bits (319), Expect = 4e-29
Identities = 135/364 (37%), Positives = 160/364 (43%), Gaps = 108/364 (29%)
Query: 286 AKRRGAATAGEKPAAKGRG--GRGPKSLGGQNPRWGRGGKKPRR-RGQKATKAAAAGTK- 341
A+RR A + + GRG G+ P S W R PRR Q A ++ + +
Sbjct: 87 AQRRSIQAAAAQEQSTGRGCLGKEPPS----QESWTRSD--PRRCLSQDAVRSGSRVCRS 140
Query: 342 ----RGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGD 397
RGGGG+Q PRRQKA+ AGAKSRGG KK
Sbjct: 141 RPQTRGGGGKQ-------------------PRRQKAAVAGAKSRGGEGKK---------- 171
Query: 398 GRKKPRWQNPRRRAQKA--PAAKPRGGGSK----KPRRRGPKAAKSRGGKSRSGGGKKPR 451
P+RR QKA AK RGGG + K RRG K A G R GGGK+PR
Sbjct: 172 ---------PQRRGQKAATAGAKSRGGGVRSLGGKKMRRGQKGA---AGAKRCGGGKQPR 219
Query: 452 RRGQKAR----------QKAAEAGAESRGDKKQGRQKASAA-------------GTKSRG 488
RRGQKA QKAA G +SR +Q QKA+AA G K RG
Sbjct: 220 RRGQKASKSGGVRCQTPQKAAAQGVKSRKKLRQRGQKAAAAGQEAAAGKTCGGGGEKHRG 279
Query: 489 GGLKSHSGKNLWRRGQKAEAAG----EKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSK 544
GG K KN RGQKA AAG +KA AAG + RK+ RRQK AVA AKS K
Sbjct: 280 GGDKKPLRKNSRWRGQKAAAAGGKKPQKAAAAGGER--RKKLRRQKAAVARAKS---PKK 334
Query: 545 SRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGG-------GDKQPGW 597
R R + + G G + R + G+ K GG D+ P W
Sbjct: 335 PRWRGQ--------NSGNGVEGQRSLAFLEFDVEGKVQRKTKIPGGVVKQFVPADQGPLW 386
Query: 598 QKAA 601
QKAA
Sbjct: 387 QKAA 390
Score = 122 bits (306), Expect = 1e-27
Identities = 117/293 (39%), Positives = 138/293 (47%), Gaps = 52/293 (17%)
Query: 469 RGDKKQGRQKASAAGTKSRGGGL--KSHSGKNLWRRGQKAEAAGEKATAAGAK------- 519
RG ++ +A+AA +S G G K + W R + A +G++
Sbjct: 84 RGRAQRRSIQAAAAQEQSTGRGCLGKEPPSQESWTRSDPRRCLSQDAVRSGSRVCRSRPQ 143
Query: 520 --SRGRKQPRRQKPAVAGAKSRVGGSKSRQR--QKAVAAGATSHGGGGNKQSRGGGGNKP 575
G KQPRRQK AVAGAKSR G K QR QKA AGA S GGG R GG K
Sbjct: 144 TRGGGGKQPRRQKAAVAGAKSRGGEGKKPQRRGQKAATAGAKSRGGG----VRSLGGKKM 199
Query: 576 RQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRR 635
R+ GQ AA R GG KQP G S+SG G + QKAA G KSRKK +R
Sbjct: 200 RR-GQKGAAGAKRCGGGKQP----RRRGQKASKSG-GVRCQTPQKAAAQGVKSRKKLRQR 253
Query: 636 GQKDAAAAEKAWA------TGATSRGSGGKQP-----RW--QKPAAAGSES-SAAAAVGQ 681
GQK AAA ++A A G RG G K+P RW QK AAAG + AAA G
Sbjct: 254 GQKAAAAGQEAAAGKTCGGGGEKHRGGGDKKPLRKNSRWRGQKAAAAGGKKPQKAAAAG- 312
Query: 682 EAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGS 734
E RKK RR Q AAV + KKPR G G + + S
Sbjct: 313 -GERRKKLRR----------QKAAVA---RAKSPKKPRWRGQNSGNGVEGQRS 351
Score = 108 bits (269), Expect = 3e-23
Identities = 105/271 (38%), Positives = 135/271 (49%), Gaps = 76/271 (28%)
Query: 53 GSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAG 112
G G K+ RRQKAA G K+R GK+ ++ QKAA AG A++RGGG
Sbjct: 146 GGGGKQPRRQKAAVAGAKSR------GGEGKKPQRRGQKAATAG-AKSRGGG-------- 190
Query: 113 TKSLGGRGRKPRRRGQKAAAT-----GSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVK 167
+SLGG K RRGQK AA G K+PR R QK++ +G GV+
Sbjct: 191 VRSLGG---KKMRRGQKGAAGAKRCGGGKQPRRRGQKASKSG---------------GVR 232
Query: 168 SQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRR 227
Q PQKAAA G KSR KK R+RG K+ G++ A GKT GG
Sbjct: 233 CQ---TPQKAAAQGVKSR--KKLRQRGQKAAA----AGQEAAA----GKTCGG------- 272
Query: 228 PKPAAGGAKSRRGGGKKP--QKQRRRGQK-AATGGKSRVGKSRGGGDKKLRRQGQNAALA 284
GG K R GG KKP + R RGQK AA GGK + GG+++ + + Q AA+A
Sbjct: 273 -----GGEKHRGGGDKKPLRKNSRWRGQKAAAAGGKKPQKAAAAGGERRKKLRRQKAAVA 327
Query: 285 GAKRRGAATAGEKPAAKGR----GGRGPKSL 311
AK + +KP +G+ G G +SL
Sbjct: 328 RAK------SPKKPRWRGQNSGNGVEGQRSL 352
Score = 97.8 bits (242), Expect = 4e-20
Identities = 82/245 (33%), Positives = 109/245 (44%), Gaps = 55/245 (22%)
Query: 616 AWRQKAAGTGAKSRKKP----WRRGQKDAAAAEKAWATGAT-------SRGSGGKQPRWQ 664
A ++++ G G ++ P W R ++ A +G+ +RG GGKQPR Q
Sbjct: 96 AAQEQSTGRGCLGKEPPSQESWTRSDPRRCLSQDAVRSGSRVCRSRPQTRGGGGKQPRRQ 155
Query: 665 KPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPW----QRRGKKPRL 720
K A AG++S KKP+RR K+ G ++ G+ RRG+K
Sbjct: 156 KAAVAGAKSRGGEG--------KKPQRRGQKAATAGAKSRGGGVRSLGGKKMRRGQKGAA 207
Query: 721 GKSRGGGGAKSRGSGGAKSRGSG------------GAKSR------------SGKKAAAS 756
G R GGG + R G S+ G G KSR +G++AAA
Sbjct: 208 GAKRCGGGKQPRRRGQKASKSGGVRCQTPQKAAAQGVKSRKKLRQRGQKAAAAGQEAAAG 267
Query: 757 KSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGG------RGQKAA 810
K+ GGGG K R GG K K GQKAAAAGGKKP + + GG R QKAA
Sbjct: 268 KTCGGGGEKHRGGGDKKPL--RKNSRWRGQKAAAAGGKKPQKAAAAGGERRKKLRRQKAA 325
Query: 811 AGGKK 815
K
Sbjct: 326 VARAK 330
Score = 94.0 bits (232), Expect = 5e-19
Identities = 90/252 (35%), Positives = 112/252 (44%), Gaps = 71/252 (28%)
Query: 586 KTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWR-QKAAGTGAKSRK--------KPWRRG 636
+TRGGG KQP QKAA KSR G+G K R QKAA GAKSR K RRG
Sbjct: 143 QTRGGGGKQPRRQKAAVAGAKSRGGEGKKPQRRGQKAATAGAKSRGGGVRSLGGKKMRRG 202
Query: 637 QKDAAAAEKAWATGATSRGSGGKQPR--WQKPAAAGSE--SSAAAAVGQEAEARKKPRRR 692
QK AA A++ GGKQPR QK + +G + A Q ++RKK R+R
Sbjct: 203 QKGAAGAKRC---------GGGKQPRRRGQKASKSGGVRCQTPQKAAAQGVKSRKKLRQR 253
Query: 693 RAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSG------------GAKSR 740
GQ AA G++ GK+ GGGG K RG G G K+
Sbjct: 254 --------GQKAAAA-------GQEAAAGKTCGGGGEKHRGGGDKKPLRKNSRWRGQKAA 298
Query: 741 GSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVK 800
+GG K +KAAA+ GG +R++ QKAA A K P + +
Sbjct: 299 AAGGKKP---QKAAAA-----GGERRKK--------------LRRQKAAVARAKSPKKPR 336
Query: 801 SRGGRGQKAAAG 812
RG G
Sbjct: 337 WRGQNSGNGVEG 348
Score = 87.4 bits (215), Expect = 5e-17
Identities = 75/192 (39%), Positives = 94/192 (48%), Gaps = 23/192 (11%)
Query: 19 GAPLGAALARTPVELAAESAAPALSAAAAGVKILGSGDKKLRRQKAAAG------GKKAR 72
GA + P ++A + GV+ LG G K R QK AAG GK+ R
Sbjct: 161 GAKSRGGEGKKPQRRGQKAATAGAKSRGGGVRSLG-GKKMRRGQKGAAGAKRCGGGKQPR 219
Query: 73 LRGQKGAVAGKEARQHWQKAAGAGGAENRGGGE--QKAAAAGT-----KSLGGRGRKPRR 125
RGQK + +G Q QKAA G + + QKAAAAG K+ GG G K R
Sbjct: 220 RRGQKASKSGGVRCQTPQKAAAQGVKSRKKLRQRGQKAAAAGQEAAAGKTCGGGGEKHRG 279
Query: 126 RGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKSR 185
G K K RWR QK+AAAG K QKAAAA G + +K ++ AA A+++
Sbjct: 280 GGDKKPL--RKNSRWRGQKAAAAGGKK----PQKAAAAGGERR---KKLRRQKAAVARAK 330
Query: 186 SGKKPRRRGAKS 197
S KKPR RG S
Sbjct: 331 SPKKPRWRGQNS 342
Score = 86.3 bits (212), Expect = 1e-16
Identities = 83/217 (38%), Positives = 109/217 (50%), Gaps = 38/217 (17%)
Query: 629 RKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEA-EARK 687
R + RR + AAA E++ T RG GK+P Q+ + + S + Q+A +
Sbjct: 84 RGRAQRRSIQAAAAQEQS-----TGRGCLGKEPPSQE---SWTRSDPRRCLSQDAVRSGS 135
Query: 688 KPRRRRAKSRGDGG-----QNAAV-GINPWQRRGKKP-RLGKSRGGGGAKSRGSGGAKSR 740
+ R R ++RG GG Q AAV G GKKP R G+ GAKSRG G R
Sbjct: 136 RVCRSRPQTRGGGGKQPRRQKAAVAGAKSRGGEGKKPQRRGQKAATAGAKSRGGG---VR 192
Query: 741 GSGGAKSRSGKKAAA-SKSHGGGGAKRRRG------GGAKSRSGEKAVTAG--------- 784
GG K R G+K AA +K GGG RRRG GG + ++ +KA G
Sbjct: 193 SLGGKKMRRGQKGAAGAKRCGGGKQPRRRGQKASKSGGVRCQTPQKAAAQGVKSRKKLRQ 252
Query: 785 -GQKAAAAGGKKPPRVKSRGGRGQKAAAGG-KKPLRR 819
GQKAAAA G++ K+ GG G+K GG KKPLR+
Sbjct: 253 RGQKAAAA-GQEAAAGKTCGGGGEKHRGGGDKKPLRK 288
>gi|239758008 PREDICTED: hypothetical protein XP_002346266 [Homo
sapiens]
Length = 316
Score = 135 bits (340), Expect = 2e-31
Identities = 120/310 (38%), Positives = 150/310 (48%), Gaps = 83/310 (26%)
Query: 153 RGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRS------GKKPRRRGAKSRGD------ 200
R + A A + +G + + AA A+ RS GK+P R + +R D
Sbjct: 68 RDSRVTPATALLPLSHRGRAQRRSMHAAAAQERSLGRGCLGKEPPNRESWTRSDPRHCIS 127
Query: 201 -EDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQ---KQRRRGQKAA 256
+ + R +SR +TRGG KK RR K AA GAKSR GGKKP+ K RRRGQK+
Sbjct: 128 QDASRSGSRVCRSR-PQTRGGGGKKPRRQKDAAAGAKSR--GGKKPRRGRKPRRRGQKST 184
Query: 257 TGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKG-RGGRGPKSLGGQN 315
G KSRG G KK R+Q KPAA G + G G K ++
Sbjct: 185 AAG----AKSRGEGGKKPRQQ-------------------KPAAAGAKSGLGDK----KS 217
Query: 316 PRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQ--QKAAVVGVKSRKKQRRRGKKPRRQKA 373
RWGR KKP R GQ+A AG GGGG+ QKAA G KS KK RR+ +K +K
Sbjct: 218 RRWGR--KKPGRWGQEAV----AGETCGGGGKKPQKAAAPGAKSHKKPRRQWQKAAAEKV 271
Query: 374 SAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGG--GSKKPRRRG 431
+ AGA+S GG R QKA AA+ + G G KK RRRG
Sbjct: 272 AVAGAESCGG--------------------------RGQKAAAARAKSGGFGGKKQRRRG 305
Query: 432 PKAAKSRGGK 441
+A KSRGG+
Sbjct: 306 QRAPKSRGGR 315
Score = 130 bits (326), Expect = 6e-30
Identities = 124/340 (36%), Positives = 151/340 (44%), Gaps = 109/340 (32%)
Query: 364 RGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGG 423
RG+ RR +AA A+ R G RG K+P P R + + PR
Sbjct: 84 RGRAQRRSMHAAA-AQERSLG----------RGCLGKEP----PNRESWTR--SDPRHCI 126
Query: 424 SKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAG 483
S+ R G + +SR ++R GGGKKPRR QK +AAG
Sbjct: 127 SQDASRSGSRVCRSRP-QTRGGGGKKPRR------------------------QKDAAAG 161
Query: 484 TKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGR--KQPRRQKPAVAGAKSRVG 541
KSRGG RRG+K G+K+TAAGAKSRG K+PR+QKPA AGAKS
Sbjct: 162 AKSRGGKKP--------RRGRKPRRRGQKSTAAGAKSRGEGGKKPRQQKPAAAGAKS--- 210
Query: 542 GSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAA 601
G G+K+SR G KP +WGQ A A +T GGG K+P
Sbjct: 211 -------------------GLGDKKSRRWGRKKPGRWGQEAVAGETCGGGGKKP------ 245
Query: 602 AGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQP 661
QKAA GAKS KKP R+ QK AAAEK GA S G G
Sbjct: 246 -----------------QKAAAPGAKSHKKPRRQWQK--AAAEKVAVAGAESCGGRG--- 283
Query: 662 RWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGG 701
QK AAA ++S Q ++ P KSRG G
Sbjct: 284 --QKAAAARAKSGGFGGKKQRRRGQRAP-----KSRGGRG 316
Score = 108 bits (270), Expect = 2e-23
Identities = 100/261 (38%), Positives = 134/261 (51%), Gaps = 41/261 (15%)
Query: 100 NRGGGEQK---AAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAG 156
+RG +++ AAAA +SLG RG + + + T S +Q ++ +GS+ +
Sbjct: 83 HRGRAQRRSMHAAAAQERSLG-RGCLGKEPPNRESWTRSDPRHCISQDASRSGSRVCRSR 141
Query: 157 AQKAAAAAGVKSQGGEKP--QKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRF 214
Q + GG+KP QK AAAGAKSR GKKP RRG K R ++G++ A
Sbjct: 142 PQ-------TRGGGGKKPRRQKDAAAGAKSRGGKKP-RRGRKPR----RRGQKSTAAG-- 187
Query: 215 GKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKL 274
K+RG KK R+ KPAA GAKS G G K ++ R + G ++ G++ GGG KK
Sbjct: 188 AKSRGEGGKKPRQQKPAAAGAKS--GLGDKKSRRWGRKKPGRWGQEAVAGETCGGGGKK- 244
Query: 275 RRQGQNAALAGAK------RRGAATAGEKPAAKGR---GGRGPKSLGGQNPRWGRGGKKP 325
Q AA GAK R+ A EK A G GGRG K+ + G GGKK
Sbjct: 245 ---PQKAAAPGAKSHKKPRRQWQKAAAEKVAVAGAESCGGRGQKAAAARAKSGGFGGKKQ 301
Query: 326 RRRGQKATKAAAAGTKRGGGG 346
RRRGQ+A K+ RGG G
Sbjct: 302 RRRGQRAPKS------RGGRG 316
Score = 101 bits (251), Expect = 3e-21
Identities = 86/219 (39%), Positives = 109/219 (49%), Gaps = 45/219 (20%)
Query: 599 KAAAGVTKSRS---GDGGKKAWRQKAAGTGAKSR--KKPWRRGQKDAAAAEKAWATGATS 653
++ + V +SR G GGKK RQK A GAKSR KKP RRG+K +K+ A GA S
Sbjct: 132 RSGSRVCRSRPQTRGGGGKKPRRQKDAAAGAKSRGGKKP-RRGRKPRRRGQKSTAAGAKS 190
Query: 654 RGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQR 713
RG GGK+PR QKPAAAG++S KK RR K G GQ A G
Sbjct: 191 RGEGGKKPRQQKPAAAGAKSGLGD---------KKSRRWGRKKPGRWGQEAVAG------ 235
Query: 714 RGKKPRLGKSRGGGGAKSRGSG--GAKSRGSGGAKSRSGKKAAASKSHGGG----GAKRR 767
++ GGGG K + + GAKS R +KAAA K G G + +
Sbjct: 236 --------ETCGGGGKKPQKAAAPGAKSHKK---PRRQWQKAAAEKVAVAGAESCGGRGQ 284
Query: 768 RGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGRG 806
+ A+++SG GG+K G + P KSRGGRG
Sbjct: 285 KAAAARAKSG----GFGGKKQRRRGQRAP---KSRGGRG 316
Score = 98.2 bits (243), Expect = 3e-20
Identities = 100/275 (36%), Positives = 124/275 (45%), Gaps = 54/275 (19%)
Query: 326 RRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGD 385
R R Q+ + AAA +R G +G + ++ PR + A SR G
Sbjct: 84 RGRAQRRSMHAAAAQERSLG----RGCLGKEPPNRESWTRSDPRHCISQDA---SRSGSR 136
Query: 386 KKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGG----GSKKPRRRGPKAAKSRGGK 441
R R G G+K PRR+ A AK RGG +KPRRRG K+ + G K
Sbjct: 137 VCRSRPQTRGGGGKK------PRRQKDAAAGAKSRGGKKPRRGRKPRRRGQKST-AAGAK 189
Query: 442 SRSGGGKKPRRRGQKARQKAAEAGAES-RGDKKQ---GRQKASAAGTKSRGGGLKSHSGK 497
SR GGKKPR +QK A AGA+S GDKK GR+K G ++ G GK
Sbjct: 190 SRGEGGKKPR------QQKPAAAGAKSGLGDKKSRRWGRKKPGRWGQEAVAGETCGGGGK 243
Query: 498 NLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKS--RQRQKAVAAG 555
+KA A GAKS K+PRRQ A K V G++S + QKA AA
Sbjct: 244 K-----------PQKAAAPGAKS--HKKPRRQWQKAAAEKVAVAGAESCGGRGQKAAAAR 290
Query: 556 ATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGG 590
A S G GG KQ R G A K+RGG
Sbjct: 291 AKSGGFGGKKQRRRG-----------QRAPKSRGG 314
Score = 92.8 bits (229), Expect = 1e-18
Identities = 96/281 (34%), Positives = 129/281 (45%), Gaps = 77/281 (27%)
Query: 25 ALARTPVELAAESAAPALSAAAAGVKILGSG---------------DKK--LRRQKAAAG 67
A A P+ + ++ AAAA + LG G D + + + + +G
Sbjct: 75 ATALLPLSHRGRAQRRSMHAAAAQERSLGRGCLGKEPPNRESWTRSDPRHCISQDASRSG 134
Query: 68 GKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRG 127
+ R R Q GK+ R+ AA GA++RGG + + RGRKPRRRG
Sbjct: 135 SRVCRSRPQTRGGGGKKPRRQKDAAA---GAKSRGGKKPR-----------RGRKPRRRG 180
Query: 128 QKAAATGSKK-----PRWRAQKSAAAGSKNRGAGAQKA--------------AAAAGVKS 168
QK+ A G+K + R QK AAAG+K+ G G +K+ A A
Sbjct: 181 QKSTAAGAKSRGEGGKKPRQQKPAAAGAKS-GLGDKKSRRWGRKKPGRWGQEAVAGETCG 239
Query: 169 QGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRP 228
GG+KPQKAAA GAKS KKPRR+ K+ + + ++ GGR +
Sbjct: 240 GGGKKPQKAAAPGAKSH--KKPRRQWQKAAAE--------KVAVAGAESCGGRGQ----- 284
Query: 229 KPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGG 269
K AA AKS GGK KQRRRGQ+A KSRGG
Sbjct: 285 KAAAARAKSGGFGGK---KQRRRGQRAP--------KSRGG 314
Score = 87.0 bits (214), Expect = 6e-17
Identities = 89/249 (35%), Positives = 106/249 (42%), Gaps = 85/249 (34%)
Query: 616 AWRQKAAGTGAKSRKKP----WRRGQKDAAAAEKAWATGAT-------SRGSGGKQPRWQ 664
A ++++ G G ++ P W R ++ A +G+ +RG GGK+PR Q
Sbjct: 96 AAQERSLGRGCLGKEPPNRESWTRSDPRHCISQDASRSGSRVCRSRPQTRGGGGKKPRRQ 155
Query: 665 KPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSR 724
K AAAG AKSRG GKKPR G+
Sbjct: 156 KDAAAG-----------------------AKSRG----------------GKKPRRGRKP 176
Query: 725 GGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAK-SRSGEKAV-- 781
G KS +G AKSRG GG K R K AAA G G K RR G K R G++AV
Sbjct: 177 RRRGQKSTAAG-AKSRGEGGKKPRQQKPAAAGAKSGLGDKKSRRWGRKKPGRWGQEAVAG 235
Query: 782 -TAGG-----QKAAAAGGK--KPPR---------------VKSRGGRGQKAAA------- 811
T GG QKAAA G K K PR +S GGRGQKAAA
Sbjct: 236 ETCGGGGKKPQKAAAPGAKSHKKPRRQWQKAAAEKVAVAGAESCGGRGQKAAAARAKSGG 295
Query: 812 -GGKKPLRR 819
GGKK RR
Sbjct: 296 FGGKKQRRR 304
Score = 79.7 bits (195), Expect = 1e-14
Identities = 62/149 (41%), Positives = 79/149 (53%), Gaps = 20/149 (13%)
Query: 44 AAAAGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGG 103
+ AAG K G G KK R+QK AA G K+ L +K G++ W + A AG E GG
Sbjct: 183 STAAGAKSRGEGGKKPRQQKPAAAGAKSGLGDKKSRRWGRKKPGRWGQEAVAG--ETCGG 240
Query: 104 G---EQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKA 160
G QKAAA G KS +KPRR+ QKAA A+K A AG+++ G QKA
Sbjct: 241 GGKKPQKAAAPGAKS----HKKPRRQWQKAA----------AEKVAVAGAESCGGRGQKA 286
Query: 161 AAA-AGVKSQGGEKPQKAAAAGAKSRSGK 188
AAA A GG+K ++ KSR G+
Sbjct: 287 AAARAKSGGFGGKKQRRRGQRAPKSRGGR 315
>gi|239753329 PREDICTED: hypothetical protein XP_002345623 [Homo
sapiens]
Length = 351
Score = 127 bits (319), Expect = 4e-29
Identities = 106/265 (40%), Positives = 135/265 (50%), Gaps = 54/265 (20%)
Query: 369 RRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPR---WQNPRRRAQKAPAAKP--RGGG 423
R +A+ A A S G G + G +R R PR +Q+ R + ++P RGGG
Sbjct: 83 RSMQATVAKAGSPGRG-RLGKEPRRRESWTRSAPRRCPYQDASRAGSRVCRSRPQNRGGG 141
Query: 424 SKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAG 483
KKPRRRG KAAKSRG GGGKKPR QKAA AGA+ ++ ++A+AAG
Sbjct: 142 DKKPRRRGQKAAKSRG-----GGGKKPR------GQKAAGAGAKKHRKPRRRGERAAAAG 190
Query: 484 TK--SRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVG 541
K + KS G G+K AAG K +PRR++ A AKSR G
Sbjct: 191 GKKLQKAAAAKSRGG------------GGKKTAAAGGK-----KPRRRRGQKA-AKSRGG 232
Query: 542 GSKSRQRQKAVAAGATSHGG-----GGNKQ--------SRGGGGNKPRQWGQTAAAAKTR 588
G K +RQKA G S G GG KQ SRGGGG KP++ AA AK+R
Sbjct: 233 GDKKLERQKAALTGVKSRGDKKPLRGGKKQRERGQNTKSRGGGGEKPQK--AAAAGAKSR 290
Query: 589 GGGDKQPGWQKAAAGVTKSRSGDGG 613
GG ++P QKA AG ++R + G
Sbjct: 291 GGRGEKP--QKAEAGQGQNRRNEVG 313
Score = 124 bits (312), Expect = 3e-28
Identities = 115/309 (37%), Positives = 146/309 (47%), Gaps = 80/309 (25%)
Query: 109 AAAGTKSLGGRGRKPRRRG------------QKAAATGSKKPRWRAQKSAAAGSKNRGAG 156
A AG+ G G++PRRR Q A+ GS+ R R Q K R G
Sbjct: 90 AKAGSPGRGRLGKEPRRRESWTRSAPRRCPYQDASRAGSRVCRSRPQNRGGGDKKPRRRG 149
Query: 157 AQKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGK 216
QKAA + G GG+KP+ AAGA ++ +KPRRRG ++ KK ++ A K
Sbjct: 150 -QKAAKSRG---GGGKKPRGQKAAGAGAKKHRKPRRRGERAAAAGGKKLQKAAA----AK 201
Query: 217 TRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRR 276
+RGG GG K+ GGKKP+ RRRGQKAA KSRGGGDKKL R
Sbjct: 202 SRGG------------GGKKTAAAGGKKPR--RRRGQKAA--------KSRGGGDKKLER 239
Query: 277 QGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAA 336
Q AAL G K RG +KP RGGKK R RGQ TK+
Sbjct: 240 Q--KAALTGVKSRG----DKKPL--------------------RGGKKQRERGQN-TKS- 271
Query: 337 AAGTKRGGGGQ--QKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKR 394
RGGGG+ QKAA G KSR RG+KP++ +A + G + L +
Sbjct: 272 -----RGGGGEKPQKAAAAGAKSRGG---RGEKPQKAEAGQGQNRRNEVGGQHNLALLEC 323
Query: 395 RGDGRKKPR 403
G+ +P+
Sbjct: 324 DVIGKVQPK 332
Score = 119 bits (297), Expect = 1e-26
Identities = 95/245 (38%), Positives = 126/245 (51%), Gaps = 43/245 (17%)
Query: 34 AAESAAPALSAAAAGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAA 93
+A P A+ AG ++ S R Q G KK R RGQK A K+
Sbjct: 113 SAPRRCPYQDASRAGSRVCRS-----RPQNRGGGDKKPRRRGQKAA-----------KSR 156
Query: 94 GAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNR 153
G GG + RG QKAA AG K + RKPRRRG++AAA G KK QK+AAA K+R
Sbjct: 157 GGGGKKPRG---QKAAGAGAK----KHRKPRRRGERAAAAGGKK----LQKAAAA--KSR 203
Query: 154 GAGAQKAAAAAGVKSQG--GEKPQKAAAAGAKSRSGKKPRRRGAKSRGDED--KKGRQRE 209
G G +K AAA G K + G+K K+ G K +K G KSRGD+ + G+++
Sbjct: 204 GGGGKKTAAAGGKKPRRRRGQKAAKSRGGGDKKLERQKAALTGVKSRGDKKPLRGGKKQR 263
Query: 210 AKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGG 269
+ + K+RGG +K + K AA GAKSR G G+KPQK A G+ + ++ G
Sbjct: 264 ERGQNTKSRGGGGEKPQ--KAAAAGAKSRGGRGEKPQK--------AEAGQGQNRRNEVG 313
Query: 270 GDKKL 274
G L
Sbjct: 314 GQHNL 318
Score = 114 bits (286), Expect = 3e-25
Identities = 108/298 (36%), Positives = 137/298 (45%), Gaps = 58/298 (19%)
Query: 248 QRRRGQ----KAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGR 303
QRR Q KA + G+ R+GK + R + A R G+ +P +G
Sbjct: 81 QRRSMQATVAKAGSPGRGRLGKEPRRRESWTRSAPRRCPYQDASRAGSRVCRSRPQNRGG 140
Query: 304 GGRGPKSLGGQNPRW-GRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQR 362
G + P+ G + + G GGKKPR GQKA A G K +K R
Sbjct: 141 GDKKPRRRGQKAAKSRGGGGKKPR--GQKAAGA------------------GAKKHRKPR 180
Query: 363 RRGKKPR----RQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAK 418
RRG++ ++ AA AKSRGGG K K G KKPR RRR QK AAK
Sbjct: 181 RRGERAAAAGGKKLQKAAAAKSRGGGGK------KTAAAGGKKPR----RRRGQK--AAK 228
Query: 419 PRGGGSKKPRRRGPKAA----KSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQ 474
RGGG KK R+ KAA KSRG K GGKK R RGQ + SRG +
Sbjct: 229 SRGGGDKKLERQ--KAALTGVKSRGDKKPLRGGKKQRERGQNTK---------SRGGGGE 277
Query: 475 GRQKASAAGTKSRGG-GLKSHSGKNLWRRGQKAEAAGEKATA-AGAKSRGRKQPRRQK 530
QKA+AAG KSRGG G K + + ++ E G+ A G+ QP+ +K
Sbjct: 278 KPQKAAAAGAKSRGGRGEKPQKAEAGQGQNRRNEVGGQHNLALLECDVIGKVQPKTKK 335
Score = 113 bits (283), Expect = 6e-25
Identities = 124/319 (38%), Positives = 137/319 (42%), Gaps = 107/319 (33%)
Query: 506 AEAAGEKATAAGAKSRGR----KQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGG 561
A+ +AT A A S GR K+PRR++ A R Q A AG S
Sbjct: 80 AQRRSMQATVAKAGSPGRGRLGKEPRRRESWTRSAPRRC------PYQDASRAG--SRVC 131
Query: 562 GGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKA 621
Q+RGGG KPR+ GQ AA K+RGGG GKK QKA
Sbjct: 132 RSRPQNRGGGDKKPRRRGQKAA--KSRGGG---------------------GKKPRGQKA 168
Query: 622 AGTGAKSRKKPWRRGQKDAAAAEKAW--ATGATSRGSGGKQPRWQKPAAAGSESSAAAAV 679
AG GAK +KP RRG++ AAA K A A SRG GGK K AAAG
Sbjct: 169 AGAGAKKHRKPRRRGERAAAAGGKKLQKAAAAKSRGGGGK-----KTAAAGG-------- 215
Query: 680 GQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKS 739
KKPRRRR GQ AA KSRGGG K A +
Sbjct: 216 -------KKPRRRR-------GQKAA----------------KSRGGGDKKLERQKAALT 245
Query: 740 RGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGG---QKAAAAGGKKP 796
G KSR KK GG +R RG KSR G GG QKAAAAG
Sbjct: 246 ----GVKSRGDKKPLR-----GGKKQRERGQNTKSRGG------GGEKPQKAAAAG---- 286
Query: 797 PRVKSRGGRG---QKAAAG 812
KSRGGRG QKA AG
Sbjct: 287 --AKSRGGRGEKPQKAEAG 303
Score = 109 bits (272), Expect = 1e-23
Identities = 106/252 (42%), Positives = 129/252 (51%), Gaps = 55/252 (21%)
Query: 315 NPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRG-KKPRRQKA 373
+P GR GK+PRRR + T++A + + V +SR + R G KKPRR+
Sbjct: 94 SPGRGRLGKEPRRR-ESWTRSAPRRCPYQDASRAGSRVC--RSRPQNRGGGDKKPRRRGQ 150
Query: 374 SAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPK 433
AA KSRGGG KK R K G G KK R PRRR ++A AA G KK ++
Sbjct: 151 KAA--KSRGGGGKKP-RGQKAAGAGAKKHR--KPRRRGERAAAA-----GGKKLQKAA-- 198
Query: 434 AAKSRGG---KSRSGGGKKPRRR-GQKA------------RQKAAEAGAESRGDKKQGR- 476
AAKSRGG K+ + GGKKPRRR GQKA RQKAA G +SRGDKK R
Sbjct: 199 AAKSRGGGGKKTAAAGGKKPRRRRGQKAAKSRGGGDKKLERQKAALTGVKSRGDKKPLRG 258
Query: 477 ---QKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAV 533
Q+ TKSRGGG + QKA AAGAKSRG + + QK
Sbjct: 259 GKKQRERGQNTKSRGGG---------GEKPQKAA-------AAGAKSRGGRGEKPQKAEA 302
Query: 534 AGAKSR---VGG 542
++R VGG
Sbjct: 303 GQGQNRRNEVGG 314
Score = 101 bits (252), Expect = 2e-21
Identities = 91/251 (36%), Positives = 125/251 (49%), Gaps = 61/251 (24%)
Query: 231 AAGGAKSRRGGGKKPQKQ--------RRRGQKAATGGKSRVGKSR----GGGDKKLRRQG 278
A G+ R GK+P+++ RR + A+ SRV +SR GGGDKK RR+G
Sbjct: 90 AKAGSPGRGRLGKEPRRRESWTRSAPRRCPYQDASRAGSRVCRSRPQNRGGGDKKPRRRG 149
Query: 279 QNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKA--- 335
Q AA K RG G+KP + G G K +KPRRRG++A A
Sbjct: 150 QKAA----KSRGGG--GKKPRGQKAAGAGAKK-----------HRKPRRRGERAAAAGGK 192
Query: 336 ----AAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPR--------RQKASAAGAKSRGG 383
AAA RGGGG++ AA G K R+++ ++ K R RQKA+ G KSRG
Sbjct: 193 KLQKAAAAKSRGGGGKKTAAAGGKKPRRRRGQKAAKSRGGGDKKLERQKAALTGVKSRG- 251
Query: 384 GDKKGLREAKRRGDGRKKPRWQNPRRRA------QKAPA--AKPRGGGSKKPRRRGPKAA 435
DKK LR K++ + R QN + R QKA A AK RGG +KP++ +A
Sbjct: 252 -DKKPLRGGKKQ-----RERGQNTKSRGGGGEKPQKAAAAGAKSRGGRGEKPQK--AEAG 303
Query: 436 KSRGGKSRSGG 446
+ + ++ GG
Sbjct: 304 QGQNRRNEVGG 314
Score = 95.9 bits (237), Expect = 1e-19
Identities = 87/233 (37%), Positives = 109/233 (46%), Gaps = 37/233 (15%)
Query: 482 AGTKSRGGGLKSHSGKNLWRRG-------QKAEAAGEKATAAGAKSRGRKQPRRQKPAVA 534
AG+ RG K + W R Q A AG + + ++RG + ++
Sbjct: 92 AGSPGRGRLGKEPRRRESWTRSAPRRCPYQDASRAGSRVCRSRPQNRGGGDKKPRRRGQK 151
Query: 535 GAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSR--GGGGNKPRQWGQTAAAAKTRGGGD 592
AKSR GG K + QKA AGA H + R GG K Q AAAAK+RGGG
Sbjct: 152 AAKSRGGGGKKPRGQKAAGAGAKKHRKPRRRGERAAAAGGKKL----QKAAAAKSRGGGG 207
Query: 593 KQPGWQKAAAGVTKSR----------SGDGGKKAWRQKAAGTGAKSR--KKPWRRGQKDA 640
K + AAAG K R G G KK RQKAA TG KSR KKP R G+K
Sbjct: 208 K----KTAAAGGKKPRRRRGQKAAKSRGGGDKKLERQKAALTGVKSRGDKKPLRGGKK-- 261
Query: 641 AAAEKAWATGATSRGSGGKQPRWQKPAAAGSES-SAAAAVGQEAEARKKPRRR 692
++ SRG GG++P QK AAAG++S Q+AEA + RR
Sbjct: 262 ---QRERGQNTKSRGGGGEKP--QKAAAAGAKSRGGRGEKPQKAEAGQGQNRR 309
Score = 75.9 bits (185), Expect = 1e-13
Identities = 72/167 (43%), Positives = 85/167 (50%), Gaps = 37/167 (22%)
Query: 666 PAAAGSESSAAAAVGQEAEAR--KKPRRRRAKSRGDGGQNAAVGINPWQ---RRGKKPRL 720
PA S + A G R K+PRRR + +R +A P+Q R G +
Sbjct: 79 PAQRRSMQATVAKAGSPGRGRLGKEPRRRESWTR------SAPRRCPYQDASRAGSRVCR 132
Query: 721 GK--SRGGGGAK--SRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRS 776
+ +RGGG K RG AKSRG GG K R G+KAA G GAK+ R R
Sbjct: 133 SRPQNRGGGDKKPRRRGQKAAKSRGGGGKKPR-GQKAA------GAGAKKHR---KPRRR 182
Query: 777 GEKAVTAGG---QKAAAAGGKKPPRVKSRGGRGQK-AAAGGKKPLRR 819
GE+A AGG QKAAAA KSRGG G+K AAAGGKKP RR
Sbjct: 183 GERAAAAGGKKLQKAAAA--------KSRGGGGKKTAAAGGKKPRRR 221
>gi|239758151 PREDICTED: hypothetical protein XP_002346314 [Homo
sapiens]
Length = 321
Score = 122 bits (306), Expect = 1e-27
Identities = 109/287 (37%), Positives = 138/287 (48%), Gaps = 64/287 (22%)
Query: 364 RGKKPRRQ-KASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGG 422
RG+ RR +A+AA +S G G G++ P+W++ R PR
Sbjct: 84 RGQVQRRSMQAAAAQEQSLGRGCL-----------GKEPPKWESSTRSG-------PRRC 125
Query: 423 GSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAA 482
S+ R G + +SR ++R GGGKKPRR QKA+ A
Sbjct: 126 LSQDASRSGSRVCRSRP-QTRGGGGKKPRRG-----------------------QKAATA 161
Query: 483 GTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGG 542
G KSRGGG++S GK + RRGQKA AAGAKS G + QK GA+ R G
Sbjct: 162 GAKSRGGGVRSRGGKKIRRRGQKA-------AAAGAKSCGGGGKKPQKARAVGARRR-GW 213
Query: 543 SKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGD--KQPGWQKA 600
K R+R K AA G +Q G KPR+ GQ AAAA GG+ K+P QKA
Sbjct: 214 KKLRRRGKKAAAAGGEKAGKKLRQQGEKGRKKPRRRGQKAAAA----GGERCKKPRRQKA 269
Query: 601 AAGVTKSRSGDGGKKAWRQ--KAAGTGAKSRKKPWRRGQKDAAAAEK 645
AA KS KK R+ +A GA+SRK P RRGQK AA +
Sbjct: 270 AAVSAKS-----PKKPRRRVLNSARLGAESRKNPQRRGQKSMAAKSR 311
Score = 109 bits (272), Expect = 1e-23
Identities = 114/290 (39%), Positives = 134/290 (46%), Gaps = 75/290 (25%)
Query: 221 RRKKHRRPKPAAGGAKSRRGGG---KKPQK---------QRRRGQKAATGGKSRVGKSR- 267
R + RR AA + G G K+P K +R Q A+ G SRV +SR
Sbjct: 84 RGQVQRRSMQAAAAQEQSLGRGCLGKEPPKWESSTRSGPRRCLSQDASRSG-SRVCRSRP 142
Query: 268 ---GGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKK 324
GGG KK RR GQ AA AGAK RG RGGKK
Sbjct: 143 QTRGGGGKKPRR-GQKAATAGAKSRGGGVRS------------------------RGGKK 177
Query: 325 PRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSR--KKQRRRGKKPRRQKASAAGAKSRG 382
RRRGQKA A A GG QKA VG + R KK RRRGK KA+AA
Sbjct: 178 IRRRGQKAAAAGAKSCGGGGKKPQKARAVGARRRGWKKLRRRGK-----KAAAA------ 226
Query: 383 GGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKS 442
GG+K G + ++ GRKK PRRR QKA AA G KKPRR+ A ++
Sbjct: 227 GGEKAGKKLRQQGEKGRKK-----PRRRGQKAAAA--GGERCKKPRRQKAAAVSAK---- 275
Query: 443 RSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLK 492
KKPRRR +A GAESR + ++ QK+ AA KSR G K
Sbjct: 276 ---SPKKPRRR----VLNSARLGAESRKNPQRRGQKSMAA--KSRVGSGK 316
Score = 103 bits (256), Expect = 8e-22
Identities = 98/273 (35%), Positives = 125/273 (45%), Gaps = 54/273 (19%)
Query: 469 RGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRR 528
RG ++ +A+AA +S G G W + + +G + + SR + R
Sbjct: 84 RGQVQRRSMQAAAAQEQSLGRGCLGKEPPK-W---ESSTRSGPRRCLSQDASRSGSRVCR 139
Query: 529 QKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAA--K 586
+P G GG K R+ QKA AGA S GGG R GG K R+ GQ AAAA K
Sbjct: 140 SRPQTRGG----GGKKPRRGQKAATAGAKSRGGG----VRSRGGKKIRRRGQKAAAAGAK 191
Query: 587 TRGGGDKQP-----------GWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRR 635
+ GGG K+P GW+K K+ + GG+KA + K G K RKKP RR
Sbjct: 192 SCGGGGKKPQKARAVGARRRGWKKLRRRGKKAAAA-GGEKAGK-KLRQQGEKGRKKPRRR 249
Query: 636 GQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAK 695
GQK AAA G K+PR QK AA ++S KKPRRR
Sbjct: 250 GQKAAAAG-----------GERCKKPRRQKAAAVSAKSP------------KKPRRRVLN 286
Query: 696 SRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGG 728
S G ++ NP QRRG+K KSR G G
Sbjct: 287 SARLGAESRK---NP-QRRGQKSMAAKSRVGSG 315
Score = 101 bits (251), Expect = 3e-21
Identities = 84/245 (34%), Positives = 114/245 (46%), Gaps = 42/245 (17%)
Query: 1 MDYRGHRQCNQAAGRAGPGAPLG-AALARTPVELAAESAAPALSAAAAGVKILGSGDKKL 59
+ +RG Q A LG L + P + + + + + GS +
Sbjct: 81 LSHRGQVQRRSMQAAAAQEQSLGRGCLGKEPPKWESSTRSGPRRCLSQDASRSGSRVCRS 140
Query: 60 RRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGE-----QKAAAAGTK 114
R Q GGKK R RGQK A AG ++R GG +RGG + QKAAAAG K
Sbjct: 141 RPQTRGGGGKKPR-RGQKAATAGAKSR--------GGGVRSRGGKKIRRRGQKAAAAGAK 191
Query: 115 SLGGRGRKP----------------RRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQ 158
S GG G+KP RRRG+KAAA G +K + ++ G K Q
Sbjct: 192 SCGGGGKKPQKARAVGARRRGWKKLRRRGKKAAAAGGEKAGKKLRQQGEKGRKKPRRRGQ 251
Query: 159 KAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRR-------GAKSRGDEDKKG-RQREA 210
KAAAA G + +KP++ AA ++S KKPRRR GA+SR + ++G + A
Sbjct: 252 KAAAAGGERC---KKPRRQKAAAVSAKSPKKPRRRVLNSARLGAESRKNPQRRGQKSMAA 308
Query: 211 KSRFG 215
KSR G
Sbjct: 309 KSRVG 313
Score = 95.5 bits (236), Expect = 2e-19
Identities = 95/297 (31%), Positives = 123/297 (41%), Gaps = 87/297 (29%)
Query: 116 LGGRGRKPRRRGQKAAAT---------GSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGV 166
L RG+ RR Q AAA G + P+W + + S R +Q A+ +
Sbjct: 81 LSHRGQVQRRSMQAAAAQEQSLGRGCLGKEPPKWES----STRSGPRRCLSQDASRSGSR 136
Query: 167 KSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHR 226
+ +PQ G K R G+K GAKSRG + +RGG++ + R
Sbjct: 137 VCRS--RPQTRGGGGKKPRRGQKAATAGAKSRGGGVR-------------SRGGKKIRRR 181
Query: 227 RPKPAAGGAKSRRGGGKKPQKQR-------------RRGQKAATGGKSRVGKSRGG---- 269
K AA GAKS GGGKKPQK R RRG+KAA G + GK
Sbjct: 182 GQKAAAAGAKSCGGGGKKPQKARAVGARRRGWKKLRRRGKKAAAAGGEKAGKKLRQQGEK 241
Query: 270 GDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRG 329
G KK RR+GQ AA AG +R KKPRR
Sbjct: 242 GRKKPRRRGQKAAAAGGER---------------------------------CKKPRR-- 266
Query: 330 QKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDK 386
QKA +A K+ +A +G +SRK +RRG+K + AKSR G K
Sbjct: 267 QKAAAVSAKSPKKPRRRVLNSARLGAESRKNPQRRGQK-------SMAAKSRVGSGK 316
Score = 91.3 bits (225), Expect = 3e-18
Identities = 101/288 (35%), Positives = 135/288 (46%), Gaps = 66/288 (22%)
Query: 42 LSAAAAGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENR 101
++ A A + + G + R +AAA +++ RG GKE + W+ + +G R
Sbjct: 72 VTPATALLLLSHRGQVQRRSMQAAAAQEQSLGRG----CLGKEPPK-WESSTRSGP---R 123
Query: 102 GGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAA 161
Q A+ +G++ R P+ RG G KKPR R QK+A AG+K+RG G
Sbjct: 124 RCLSQDASRSGSRVCRSR---PQTRGG-----GGKKPR-RGQKAATAGAKSRGGG----- 169
Query: 162 AAAGVKSQGGEK----PQKAAAAGAKS--RSGKKPRRRGAKSRGDEDKKGRQREAKSRFG 215
V+S+GG+K QKAAAAGAKS GKKP++ A G
Sbjct: 170 ----VRSRGGKKIRRRGQKAAAAGAKSCGGGGKKPQKARA------------------VG 207
Query: 216 KTRGGRRKKHRRPKPAAG------GAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSR-- 267
R G +K RR K AA G K R+ G K +K RRRGQKAA G R K R
Sbjct: 208 ARRRGWKKLRRRGKKAAAAGGEKAGKKLRQQGEKGRKKPRRRGQKAAAAGGERCKKPRRQ 267
Query: 268 ------GGGDKKLRRQGQNAALAGAK-RRGAATAGEKP-AAKGRGGRG 307
KK RR+ N+A GA+ R+ G+K AAK R G G
Sbjct: 268 KAAAVSAKSPKKPRRRVLNSARLGAESRKNPQRRGQKSMAAKSRVGSG 315
Score = 82.0 bits (201), Expect = 2e-15
Identities = 71/202 (35%), Positives = 97/202 (48%), Gaps = 39/202 (19%)
Query: 634 RRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAE-ARKKPRRR 692
RR + AAA E++ G G + P+W+ +G + Q+A + + R
Sbjct: 89 RRSMQAAAAQEQSLGRGCL----GKEPPKWESSTRSGPRR----CLSQDASRSGSRVCRS 140
Query: 693 RAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKK 752
R ++RG GG KKPR G+ GAKSRG GG +SRG + R K
Sbjct: 141 RPQTRGGGG--------------KKPRRGQKAATAGAKSRG-GGVRSRGGKKIRRRGQKA 185
Query: 753 AAA-SKSHGGGGAK--RRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRG------ 803
AAA +KS GGGG K + R GA+ R +K G + AAA G K +++ +G
Sbjct: 186 AAAGAKSCGGGGKKPQKARAVGARRRGWKKLRRRGKKAAAAGGEKAGKKLRQQGEKGRKK 245
Query: 804 --GRGQKAAAGG----KKPLRR 819
RGQKAAA G KKP R+
Sbjct: 246 PRRRGQKAAAAGGERCKKPRRQ 267
Score = 62.0 bits (149), Expect = 2e-09
Identities = 53/172 (30%), Positives = 73/172 (42%), Gaps = 44/172 (25%)
Query: 657 GGKQPRWQKPAAAGSESSAAAAVGQE-----AEARKKPRRRRAKSRGDGGQNAAVGINPW 711
G Q R + AAA +S +G+E + R PRR ++ G
Sbjct: 85 GQVQRRSMQAAAAQEQSLGRGCLGKEPPKWESSTRSGPRRCLSQDASRSGS--------- 135
Query: 712 QRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGG 771
R+ +SR ++RG GG K R G+KAA + + GG R RGG
Sbjct: 136 -------RVCRSR------------PQTRGGGGKKPRRGQKAATAGAKSRGGGVRSRGGK 176
Query: 772 AKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGG----------RGQKAAAGG 813
R G+KA AG K+ GGKKP + ++ G RG+KAAA G
Sbjct: 177 KIRRRGQKAAAAGA-KSCGGGGKKPQKARAVGARRRGWKKLRRRGKKAAAAG 227
>gi|239741651 PREDICTED: hypothetical protein XP_002342270 [Homo
sapiens]
Length = 337
Score = 115 bits (287), Expect = 2e-25
Identities = 102/278 (36%), Positives = 130/278 (46%), Gaps = 51/278 (18%)
Query: 286 AKRRG--AATAGEKPAAKGRGGRGP--KSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTK 341
A+RR AA A E+ + R G+ P + ++ W + R G + ++
Sbjct: 80 AQRRSMRAAAAQERSPGRRRLGKEPLIRESWTRSAPWRCLSQDAGRAGSQV--CGSSPQT 137
Query: 342 RGGGGQ----QKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGD 397
RGGGG+ QKA V+G KSRKK + G QKA+ AGAKS GGG KK
Sbjct: 138 RGGGGKKLQRQKATVMGAKSRKKPQHWG-----QKAATAGAKSPGGGGKK---------- 182
Query: 398 GRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSR--------GGKSRSGGGKK 449
P + P +K AAK RGGG KKPRR P AA ++ G K R GG+K
Sbjct: 183 ----PGQEKPAATGEKTRAAKSRGGGGKKPRREKPAAAGAKNPQKAAAAGAKFREAGGRK 238
Query: 450 PRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKA--E 507
PR RG QKA EAGA+SRG QK +AAG K H GK RRGQ +
Sbjct: 239 PRWRG----QKATEAGAKSRGGGGIKPQKPAAAGA-------KIHGGKKPRRRGQSSGNG 287
Query: 508 AAGEKATA-AGAKSRGRKQPRRQKPAVAGAKSRVGGSK 544
G+ + A G+ Q + K SR GS+
Sbjct: 288 VEGQNSLAFLECDVEGKVQRKTNKDNPRRESSRCTGSQ 325
Score = 110 bits (276), Expect = 4e-24
Identities = 77/163 (47%), Positives = 92/163 (56%), Gaps = 35/163 (21%)
Query: 53 GSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGG-----EQK 107
G G KKL+RQKA G K+R + Q HW + A GA++ GGG ++K
Sbjct: 139 GGGGKKLQRQKATVMGAKSRKKPQ-----------HWGQKAATAGAKSPGGGGKKPGQEK 187
Query: 108 AAAAG-----TKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKA-- 160
AA G KS GG G+KPRR +K AA G+K P QK+AAAG+K R AG +K
Sbjct: 188 PAATGEKTRAAKSRGGGGKKPRR--EKPAAAGAKNP----QKAAAAGAKFREAGGRKPRW 241
Query: 161 ----AAAAGVKSQGGE--KPQKAAAAGAKSRSGKKPRRRGAKS 197
A AG KS+GG KPQK AAAGAK GKKPRRRG S
Sbjct: 242 RGQKATEAGAKSRGGGGIKPQKPAAAGAKIHGGKKPRRRGQSS 284
Score = 106 bits (265), Expect = 8e-23
Identities = 94/285 (32%), Positives = 132/285 (46%), Gaps = 39/285 (13%)
Query: 141 RAQKSA--AAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSR 198
RAQ+ + AA ++ R G ++ ++ + R+G + ++R
Sbjct: 79 RAQRRSMRAAAAQERSPGRRRLGKEPLIRESWTRSAPWRCLSQDAGRAGSQVCGSSPQTR 138
Query: 199 GDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATG 258
G KK ++++A K+R ++ +H K A GAKS GGGKKP +++ AATG
Sbjct: 139 GGGGKKLQRQKATVMGAKSR--KKPQHWGQKAATAGAKSPGGGGKKPGQEK----PAATG 192
Query: 259 GKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRW 318
K+R KSRGGG KK RR + A AGAK +K AA G R
Sbjct: 193 EKTRAAKSRGGGGKKPRR--EKPAAAGAKN------PQKAAAAGAKFR------------ 232
Query: 319 GRGGKKPRRRGQKATKAAAAGTKRGGGG--QQKAAVVGVKSRKKQRRRGKKPRRQKASAA 376
GG+KPR RGQKAT+A A RGGGG QK A G K GKKPRR+ S+
Sbjct: 233 EAGGRKPRWRGQKATEAGA--KSRGGGGIKPQKPAAAGAKI-----HGGKKPRRRGQSSG 285
Query: 377 GAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRG 421
G + E G ++K NPRR + + ++ G
Sbjct: 286 NGVE--GQNSLAFLECDVEGKVQRKTNKDNPRRESSRCTGSQVLG 328
Score = 98.6 bits (244), Expect = 2e-20
Identities = 70/168 (41%), Positives = 86/168 (51%), Gaps = 15/168 (8%)
Query: 603 GVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPR 662
G + G GGKK RQKA GAKSRKKP GQK A A GA S G GGK+P
Sbjct: 132 GSSPQTRGGGGKKLQRQKATVMGAKSRKKPQHWGQKAATA-------GAKSPGGGGKKPG 184
Query: 663 WQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRG--DGGQNAAVGINPWQRRGKKPR- 719
+KPAA G ++ AA + G KKPRR + + G + + AA G + G+KPR
Sbjct: 185 QEKPAATGEKTRAAKSRG---GGGKKPRREKPAAAGAKNPQKAAAAGAKFREAGGRKPRW 241
Query: 720 LGKSRGGGGAKSRGSGGAKSR--GSGGAKSRSGKKAAASKSHGGGGAK 765
G+ GAKSRG GG K + + GAK GKK G G +
Sbjct: 242 RGQKATEAGAKSRGGGGIKPQKPAAAGAKIHGGKKPRRRGQSSGNGVE 289
Score = 98.2 bits (243), Expect = 3e-20
Identities = 89/271 (32%), Positives = 118/271 (43%), Gaps = 75/271 (27%)
Query: 453 RGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEK 512
R Q+ +AA A S G ++ G++ + W R +
Sbjct: 79 RAQRRSMRAAAAQERSPGRRRLGKEPLI----------------RESWTRSAPWRCLSQD 122
Query: 513 ATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGG 572
A AG++ G + ++R GG K QRQKA GA S
Sbjct: 123 AGRAGSQVCG-----------SSPQTRGGGGKKLQRQKATVMGAKSR------------- 158
Query: 573 NKPRQWGQTAAAA--KTRGGGDKQPGWQKAAAG-----VTKSRSGDGGKKAWRQKAAGTG 625
KP+ WGQ AA A K+ GGG K+PG +K AA KSR G GGKK R+K A G
Sbjct: 159 KKPQHWGQKAATAGAKSPGGGGKKPGQEKPAATGEKTRAAKSRGG-GGKKPRREKPAAAG 217
Query: 626 AKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRW--QKPAAAGSESSAA------- 676
AK+ +KA A GA R +GG++PRW QK AG++S
Sbjct: 218 AKN--------------PQKAAAAGAKFREAGGRKPRWRGQKATEAGAKSRGGGGIKPQK 263
Query: 677 -AAVGQEAEARKKPRRRRAKSRGDG--GQNA 704
AA G + KKP RRR +S G+G GQN+
Sbjct: 264 PAAAGAKIHGGKKP-RRRGQSSGNGVEGQNS 293
Score = 96.7 bits (239), Expect = 8e-20
Identities = 89/266 (33%), Positives = 121/266 (45%), Gaps = 36/266 (13%)
Query: 408 RRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAE 467
+RR+ +A AA+ R G RRR K R +RS + + +A + + +
Sbjct: 81 QRRSMRAAAAQERSPG----RRRLGKEPLIRESWTRSAPWRCLSQDAGRAGSQVCGSSPQ 136
Query: 468 SRGD--KKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQ 525
+RG KK RQKA+ G KSR K GQKA AG K+ G K G+++
Sbjct: 137 TRGGGGKKLQRQKATVMGAKSR---------KKPQHWGQKAATAGAKSPGGGGKKPGQEK 187
Query: 526 PRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATS--HGGGGNKQSRGGGGNKPRQWGQ--T 581
P AKSR GG K +R+K AAGA + + R GG KPR GQ T
Sbjct: 188 PAATGEKTRAAKSRGGGGKKPRREKPAAAGAKNPQKAAAAGAKFREAGGRKPRWRGQKAT 247
Query: 582 AAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQ-KAAGTGAKSRK---------- 630
A AK+RGGG +P QK AA K GGKK R+ +++G G + +
Sbjct: 248 EAGAKSRGGGGIKP--QKPAAAGAKIH---GGKKPRRRGQSSGNGVEGQNSLAFLECDVE 302
Query: 631 -KPWRRGQKDAAAAEKAWATGATSRG 655
K R+ KD E + TG+ G
Sbjct: 303 GKVQRKTNKDNPRRESSRCTGSQVLG 328
Score = 72.0 bits (175), Expect = 2e-12
Identities = 74/214 (34%), Positives = 93/214 (43%), Gaps = 66/214 (30%)
Query: 628 SRKKPWRRGQKDAA-AAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEAR 686
+R PWR +DA A + + +RG GGK+ + QK G++S R
Sbjct: 111 TRSAPWRCLSQDAGRAGSQVCGSSPQTRGGGGKKLQRQKATVMGAKS------------R 158
Query: 687 KKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAK 746
KKP+ GQ AA GAKS G GG K G K
Sbjct: 159 KKPQH--------WGQKAATA--------------------GAKSPGGGGKK---PGQEK 187
Query: 747 -SRSGKKAAASKSHGGGGAKRRR--GGGAKSRSGEKAVTAGGQKAAAAGGKKP------- 796
+ +G+K A+KS GGGG K RR A +++ +KA AG K AGG+KP
Sbjct: 188 PAATGEKTRAAKSRGGGGKKPRREKPAAAGAKNPQKAAAAGA-KFREAGGRKPRWRGQKA 246
Query: 797 --PRVKSRGGRG---QKAAA------GGKKPLRR 819
KSRGG G QK AA GGKKP RR
Sbjct: 247 TEAGAKSRGGGGIKPQKPAAAGAKIHGGKKPRRR 280
>gi|57864582 hornerin [Homo sapiens]
Length = 2850
Score = 103 bits (257), Expect = 6e-22
Identities = 168/820 (20%), Positives = 292/820 (35%), Gaps = 99/820 (12%)
Query: 53 GSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEAR--QHWQKAAGAGGAENRGGGEQKAAA 110
GSG Q + G +GQ G+ +G+ + Q + +RG G +++
Sbjct: 1290 GSGHSSAYSQHGSGSGHFCS-QGQHGSTSGQSSTFDQEGSSTGQSSSYGHRGSGSSQSSG 1348
Query: 111 AGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQG 170
G G R R + S + + ++ S G+G+ +++ +S
Sbjct: 1349 YGRHGAGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSS 1408
Query: 171 GEKP---QKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRR 227
+ Q + +G S + R G SRG+ + G + S +G+ G R+
Sbjct: 1409 WQSSGCTQHGSGSGHSSSYEQHGSRSGQSSRGE--RHGSSSGSSSSYGQHGSGSRQ---- 1462
Query: 228 PKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAK 287
+ G + G G+ P R G+ + G+S G G +
Sbjct: 1463 ---SLGHGQHGSGSGQSPSPSR--GRHGSGSGQSSSYSPYGSGS------------GWSS 1505
Query: 288 RRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQ 347
RG +G ++ G G R +S GQ+ +G+ G + +G G
Sbjct: 1506 SRGPYESGSSHSS-GLGHRESRS--GQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCG-- 1560
Query: 348 QKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNP 407
Q A G S Q G ++S G + G G G +R R+ P +
Sbjct: 1561 QHGASSGQSSSHGQHGSGSS----QSSGYGRQGSGSGQSPG--HGQRGSGSRQSPSYGRH 1614
Query: 408 RRRAQKAPAAKPRGGGSKKPRRRGPKAAKS----------RGGKSRSGGGKKPRRRGQKA 457
+ ++ ++ G G + G + S G SG G+ R GQ +
Sbjct: 1615 GSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSS 1674
Query: 458 RQKAAEAGAESR---GDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKAT 514
R + + + S G G +++S G + G G G++ G + +
Sbjct: 1675 RGERHGSSSRSSSRYGQHGSGSRQSSGHGRQGSGSGQSPSRGRHGSGLGHSSSHGQHGSG 1734
Query: 515 AAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGA-TSHGGGGNKQSRGGGGN 573
+ + SRG + R +V G G S Q +G S G G+ + +
Sbjct: 1735 SGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFD 1794
Query: 574 KPRQWGQTAAAAKTRGGGDKQP---GWQKAAAGVTKSR----SGDGGKKAWRQKAAGTGA 626
+ +++ G G Q G Q + +G + SR SG G ++ Q +G+G
Sbjct: 1795 QEGSSTGQSSSHGQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGW 1854
Query: 627 KSRKKPWRRGQKDAAA----AEKAW-ATGATSRGSG-GKQPRWQKPAAAGSESSAAAAVG 680
S G ++ +W ++G T GSG G +++ + +SS G
Sbjct: 1855 SSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGEQHG 1914
Query: 681 QEAEARKKPRRRRAKSR---GDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGA 737
+ + + + SR G G + G +P RG R G G+ S G
Sbjct: 1915 SSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRG--------RHGSGSGQSSSYGP 1966
Query: 738 KSRGSGGAKSRSGKKAAASKSHGGGGAKRRRG-----------GGAKSRSGEKAVTAG-- 784
GSG + SR ++ + S G G + R G G S G+ +G
Sbjct: 1967 YGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSASGQS 2026
Query: 785 ---GQKAAAAG-----GKKPPRVKSRGGRGQKAAAGGKKP 816
GQ A++G G+ G G++ + G+ P
Sbjct: 2027 SSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSP 2066
Score = 99.4 bits (246), Expect = 1e-20
Identities = 163/789 (20%), Positives = 279/789 (35%), Gaps = 80/789 (10%)
Query: 53 GSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEAR--QHWQKAAGAGGAENRGGGEQKAAA 110
GSG Q + G +GQ G+ +G+ + Q + G G ++++
Sbjct: 1760 GSGHSSAYSQHGSGSGHFCS-QGQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSS 1818
Query: 111 AGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKS-- 168
G + G R R + S + + ++ S G+G+ +++ +S
Sbjct: 1819 YGQQGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSS 1878
Query: 169 -QGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRR 227
Q Q + +G S + R G SRG++ G + S +G+ G R+
Sbjct: 1879 WQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGEQH--GSSSGSSSSYGQHGSGSRQ---- 1932
Query: 228 PKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAK 287
+ G + G G+ P R G+ + G+S G G +
Sbjct: 1933 ---SLGHGQHGSGSGQSPSPSR--GRHGSGSGQSSSYGPYGSGS------------GWSS 1975
Query: 288 RRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQ 347
RG +G ++ G G R +S GQ+ +G+ G +A+G G
Sbjct: 1976 SRGPYESGSGHSS-GLGHRESRS--GQSSGYGQHGSSSGHSSTHGQHGSASGQSSSCG-- 2030
Query: 348 QKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNP 407
Q A G S Q G ++S G + G G G +R R+ P +
Sbjct: 2031 QHGASSGQSSSHGQHGSGSS----QSSGYGRQGSGSGQSPG--HGQRGSGSRQSPSYGRH 2084
Query: 408 RRRAQKAPAAKPRGGGSKKPRRRGPKAAKS----------RGGKSRSGGGKKPRRRGQKA 457
+ ++ ++ G G + G + S G SG G+ R GQ +
Sbjct: 2085 GSGSGRSSSSGQHGPGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSS 2144
Query: 458 R--QKAAEAGAESR-GDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKAT 514
R + + +G+ SR G G +++S G + G G G++ G + +
Sbjct: 2145 RGERHGSSSGSSSRYGQHGSGSRQSSGHGRQGSGSGHSPSRGRHGSGSGHSSSHGQHGSG 2204
Query: 515 AAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGA-TSHGGGGNKQSRGGGGN 573
+ + SRG + R +V G G S Q +G S G G+ + +
Sbjct: 2205 SGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFD 2264
Query: 574 KPRQWGQTAAAAKTRGGGDKQP---GWQKAAAGVTKSR----SGDGGKKAWRQKAAGTGA 626
+ +++ G G Q G Q + +G + SR SG G ++ Q +G+G
Sbjct: 2265 QEGSSTGQSSSHGQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGW 2324
Query: 627 KSRKKPWRRGQKDAAA----AEKAW-ATGATSRGSG-GKQPRWQKPAAAGSESSAAAAVG 680
S G ++ +W ++G T GSG G +++ + +SS G
Sbjct: 2325 SSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGERHG 2384
Query: 681 QEAEARKKPRRRRAKSR---GDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGA 737
+ + + + SR G G + G +P SRG G+ S S
Sbjct: 2385 SSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSP----------SPSRGRHGSGSGQSSSY 2434
Query: 738 KSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPP 797
GSG S S + H G R G S G+ ++G G
Sbjct: 2435 SPYGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSG 2494
Query: 798 RVKSRGGRG 806
+ S G G
Sbjct: 2495 QSSSCGQHG 2503
Score = 98.6 bits (244), Expect = 2e-20
Identities = 176/859 (20%), Positives = 307/859 (35%), Gaps = 90/859 (10%)
Query: 6 HRQCNQAAGRAGP-GAPLGAALARTPVELAAESAAPALSAAAAGVKILGSGDKKLRRQKA 64
H ++ + GP G G + +R P E + ++ G + SG Q
Sbjct: 548 HESGSRQSSSYGPHGYGSGRSSSRGPYESGSGHSS------GLGHQESRSGQSSGYGQHG 601
Query: 65 AAGGKKARLRGQKGAVAGKEAR--QHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRK 122
++ G + GQ G+ +G+ + QH + + G G +++ G + G G+
Sbjct: 602 SSSGHSST-HGQHGSTSGQSSSCGQHGATSGQSSSHGQHGSGSSQSSRYGQQG-SGSGQS 659
Query: 123 PRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAA-GVKSQGGEKPQKAAAAG 181
P R G+ + G + + S N G+ ++ G KS G+ +
Sbjct: 660 PSR-GRHGSDFGHSSSYGQHGSGSGWSSSNGPHGSVSGQSSGFGHKSGSGQSSGYSQHGS 718
Query: 182 AKSRSG---KKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKK--HRRPKPAAGGAK 236
S S K R G SR ++ G S +G+ G + H R +G +
Sbjct: 719 GSSHSSGYRKHGSRSGQSSRSEQH--GSSSGLSSSYGQHGSGSHQSSGHGRQGSGSGHSP 776
Query: 237 SRRGGGKKPQKQRRRGQ--------------KAATGGKSRVGKSRGGGDKKLRRQGQNAA 282
SR G GQ ++ +G S G+ G + + G +
Sbjct: 777 SRVRHGSSSGHSSSHGQHGSGTSCSSSCGHYESGSGQASGFGQHESGSGQGYSQHGSASG 836
Query: 283 LAGAKRRGAATAGEKPAA-KGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTK 341
++ R +T+G+ ++ + G S GQ+ R G + ++ G +
Sbjct: 837 HFSSQGRHGSTSGQSSSSGQHDSSSGQSSSYGQHESASHHASGRGRHGSGSGQSPGHGQR 896
Query: 342 RGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKK 401
G GQ + + G+ S+ G G + G G
Sbjct: 897 GSGSGQSPSYGRHGSGSGRSSSSGRHGSGSGQSSGFGHKSSSGQSSGYTQ-HGSGSGHSS 955
Query: 402 PRWQNPRRRAQKAPAAK--PRGGGSKKPRRRGPKAAKSRG-GKSRSGGGKKPRRRGQKAR 458
Q+ R Q + + + G S + G + +S G G+ SG G+ P + R
Sbjct: 956 SYEQHGSRSGQSSRSEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSP--SRGR 1013
Query: 459 QKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGA 518
+ + S G + G +S+ G G G S G R GQ + G+ +++G
Sbjct: 1014 HGSGSGQSSSYGPYRSGSGWSSSRGPYESGSGHSSGLGHRESRSGQ-SSGYGQHGSSSGH 1072
Query: 519 KSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAG-ATSHG--GGGNKQSRGGGGNKP 575
S G G S Q ++G ++SHG G G+ QS G G +
Sbjct: 1073 SS------------THGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQS-SGYGRQG 1119
Query: 576 RQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRR 635
GQ+ + G + P + + +G +S S G + +++G G
Sbjct: 1120 SGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRS-SSSGQHGSGLGESSGFGHHESSS---- 1174
Query: 636 GQKDAAAAEKAWATGATSRGS-GGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRA 694
GQ + + + + ++ G G + + + GS S +++ GQ +
Sbjct: 1175 GQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGSSSHYGQHGSGSR------- 1227
Query: 695 KSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAA 754
+S G G Q + G +P R LG S G GSG +S G +SRSG +
Sbjct: 1228 QSSGHGRQGSGSGHSP-SRGRHGSGLGHSSSHG---QHGSGSGRSSSRGPYESRSGHSSV 1283
Query: 755 ASKSHGGGG-----AKRRRGGGAKSRSGEKAVTAG-----GQKAAAAG-----GKKPPRV 799
+ G G ++ G G G+ T+G Q+ ++ G G +
Sbjct: 1284 FGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSYGHRGSGS 1343
Query: 800 KSRGGRGQKAAAGGKKPLR 818
G G+ A G+ P R
Sbjct: 1344 SQSSGYGRHGAGSGQSPSR 1362
Score = 98.2 bits (243), Expect = 3e-20
Identities = 169/762 (22%), Positives = 281/762 (36%), Gaps = 92/762 (12%)
Query: 54 SGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGT 113
SG Q +A G+ + GQ GA +G+ + H Q G+G +++ G G Q + + +
Sbjct: 2010 SGHSSTHGQHGSASGQSSSC-GQHGASSGQSS-SHGQH--GSGSSQSSGYGRQGSGSGQS 2065
Query: 114 KSLGGRGRKPRRR---GQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKS-Q 169
G RG R+ G+ + +G +S+++G G G S Q
Sbjct: 2066 PGHGQRGSGSRQSPSYGRHGSGSG---------RSSSSGQHGPGLGESSGFGHHESSSGQ 2116
Query: 170 GGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPK 229
Q + +G S G+ R G SRG+ + G + SR+G+ G R+
Sbjct: 2117 SSSYSQHGSGSGHSSGYGQHGSRSGQSSRGE--RHGSSSGSSSRYGQHGSGSRQ------ 2168
Query: 230 PAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRR 289
++G + G G P RG+ + G S G G + +G + +G
Sbjct: 2169 -SSGHGRQGSGSGHSPS----RGRHGSGSGHSSSHGQHGSGSGRSSSRGPYESRSGH--- 2220
Query: 290 GAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQK 349
++ G+ + G G S Q+ G G +GQ + + + T Q+
Sbjct: 2221 -SSVFGQHES-----GSGHSSAYSQH---GSGSGHFCSQGQHGSTSGQSSTF-----DQE 2266
Query: 350 AAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRR 409
+ G S Q G ++S+ G + G G R G G Q+
Sbjct: 2267 GSSTGQSSSHGQHGSGSS----QSSSYGQQGSGSGQSPS-RGRHGSGSGHSSSYGQHGSG 2321
Query: 410 RAQKAPAAKPRGGGSKKPRRRGPKAAKS--RGGKSRSGGGKKPRRRGQKARQKAAEAGAE 467
+ + + G GS + G + S G ++ G G Q + +G
Sbjct: 2322 SGWSSSSGR-HGSGSGQSSGFGHHESSSWQSSGYTQHGSGSG---HSSSYEQHGSRSGQS 2377
Query: 468 SRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAA-GAKSRGRKQP 526
SRG++ G S++ G G + G GQ +G+ + + G G Q
Sbjct: 2378 SRGER-HGSSSGSSSSYGQHGSGSRQSLG-----HGQHGSGSGQSPSPSRGRHGSGSGQS 2431
Query: 527 RRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAK 586
P +G+ G S SR ++ G+ G G+++SR G + Q G ++ +
Sbjct: 2432 SSYSPYGSGS----GWSSSRGPYES---GSGHSSGLGHRESRSGQSSGYGQHGSSSGHSS 2484
Query: 587 TRG------GGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDA 640
T G G G A++G + S G + G+ S + P GQ+ +
Sbjct: 2485 THGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGH-GQRGS 2543
Query: 641 AAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDG 700
+ + + G GSG Q + G S ++ + G
Sbjct: 2544 GSRQSP-SYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSG 2602
Query: 701 -GQNAAVG--INPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKS----RSGKKA 753
GQ+ + + +R G G G+ SR S G +GSG +S R G
Sbjct: 2603 YGQHGSRSGQSSRGERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGQSPSRGRHGSGL 2662
Query: 754 AASKSHG--GGGAKRRRGGGA-KSRSGEKAVTAGGQKAAAAG 792
S SHG G G+ R G +SR G +V GQ + +G
Sbjct: 2663 GHSSSHGQHGSGSGRSSSRGPYESRLGHSSVF--GQHESGSG 2702
Score = 97.8 bits (242), Expect = 4e-20
Identities = 169/762 (22%), Positives = 280/762 (36%), Gaps = 92/762 (12%)
Query: 54 SGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGT 113
SG Q + G+ + GQ GA +G+ + H Q G+G +++ G G Q + + +
Sbjct: 1070 SGHSSTHGQHGSTSGQSSSC-GQHGASSGQSS-SHGQH--GSGSSQSSGYGRQGSGSGQS 1125
Query: 114 KSLGGRGRKPRRR---GQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKS-Q 169
G RG R+ G+ + +G +S+++G G G S Q
Sbjct: 1126 PGHGQRGSGSRQSPSYGRHGSGSG---------RSSSSGQHGSGLGESSGFGHHESSSGQ 1176
Query: 170 GGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPK 229
Q + +G S G+ R G SRG+ + G + S +G+ G R+
Sbjct: 1177 SSSYSQHGSGSGHSSGYGQHGSRSGQSSRGE--RHGSSSGSSSHYGQHGSGSRQ------ 1228
Query: 230 PAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRR 289
++G + G G P RG+ + G S G G + +G + +G
Sbjct: 1229 -SSGHGRQGSGSGHSPS----RGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRSGH--- 1280
Query: 290 GAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQK 349
++ G+ + G G S Q+ G G +GQ + + + T Q+
Sbjct: 1281 -SSVFGQHES-----GSGHSSAYSQH---GSGSGHFCSQGQHGSTSGQSSTF-----DQE 1326
Query: 350 AAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRR 409
+ G S R G ++S G G G R G G Q+
Sbjct: 1327 GSSTGQSSSYGHRGSGSS----QSSGYGRHGAGSGQSPS-RGRHGSGSGHSSSYGQHGSG 1381
Query: 410 RAQKAPAAKPRGGGSKKPRRRGPKAAKS--RGGKSRSGGGKKPRRRGQKARQKAAEAGAE 467
+ + + G GS + G + S G ++ G G Q + +G
Sbjct: 1382 SGWSSSSGR-HGSGSGQSSGFGHHESSSWQSSGCTQHGSGSG---HSSSYEQHGSRSGQS 1437
Query: 468 SRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAA-GAKSRGRKQP 526
SRG++ G S++ G G + G GQ +G+ + + G G Q
Sbjct: 1438 SRGER-HGSSSGSSSSYGQHGSGSRQSLG-----HGQHGSGSGQSPSPSRGRHGSGSGQS 1491
Query: 527 RRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAK 586
P +G+ G S SR ++ G++ G G+++SR G + Q G ++ +
Sbjct: 1492 SSYSPYGSGS----GWSSSRGPYES---GSSHSSGLGHRESRSGQSSGYGQHGSSSGHSS 1544
Query: 587 TRG------GGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDA 640
T G G G A++G + S G + G+ S + P GQ+ +
Sbjct: 1545 THGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGH-GQRGS 1603
Query: 641 AAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDG 700
+ + + G GSG Q + G S ++ + G
Sbjct: 1604 GSRQSP-SYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSG 1662
Query: 701 -GQNAAVG--INPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKS----RSGKKA 753
GQ+ + + +R G R G G+ SR S G +GSG +S R G
Sbjct: 1663 YGQHGSRSGQSSRGERHGSSSRSSSRYGQHGSGSRQSSGHGRQGSGSGQSPSRGRHGSGL 1722
Query: 754 AASKSHG--GGGAKRRRGGGA-KSRSGEKAVTAGGQKAAAAG 792
S SHG G G+ R G +SRSG +V GQ + +G
Sbjct: 1723 GHSSSHGQHGSGSGRSSSRGPYESRSGHSSVF--GQHESGSG 1762
Score = 97.8 bits (242), Expect = 4e-20
Identities = 171/762 (22%), Positives = 286/762 (37%), Gaps = 92/762 (12%)
Query: 54 SGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGT 113
SG Q + G+ + GQ GA +G+ + H Q G+G +++ G G Q + + +
Sbjct: 1540 SGHSSTHGQHGSTSGQSSSC-GQHGASSGQSS-SHGQH--GSGSSQSSGYGRQGSGSGQS 1595
Query: 114 KSLGGRGRKPRRR---GQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKS-Q 169
G RG R+ G+ + +G +S+++G G G S Q
Sbjct: 1596 PGHGQRGSGSRQSPSYGRHGSGSG---------RSSSSGQHGSGLGESSGFGHHESSSGQ 1646
Query: 170 GGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPK 229
Q + +G S G+ R G SRG+ + G + SR+G+ G R+
Sbjct: 1647 SSSYSQHGSGSGHSSGYGQHGSRSGQSSRGE--RHGSSSRSSSRYGQHGSGSRQ------ 1698
Query: 230 PAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRR 289
++G + G G+ P RG+ + G S G G + +G + +G
Sbjct: 1699 -SSGHGRQGSGSGQSPS----RGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRSGH--- 1750
Query: 290 GAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQK 349
++ G+ + G G S Q+ G G +GQ + + + T Q+
Sbjct: 1751 -SSVFGQHES-----GSGHSSAYSQH---GSGSGHFCSQGQHGSTSGQSSTF-----DQE 1796
Query: 350 AAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRR 409
+ G S Q G ++S+ G + G G R G G Q+
Sbjct: 1797 GSSTGQSSSHGQHGSGSS----QSSSYGQQGSGSGQSPS-RGRHGSGSGHSSSYGQHGSG 1851
Query: 410 RAQKAPAAKPRGGGSKKPRRRGPKAAKS--RGGKSRSGGGKKPRRRGQKARQKAAEAGAE 467
+ + + G GS + G + S G ++ G G Q + +G
Sbjct: 1852 SGWSSSSGR-HGSGSGQSSGFGHHESSSWQSSGYTQHGSGSG---HSSSYEQHGSRSGQS 1907
Query: 468 SRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAA-GAKSRGRKQP 526
SRG+ Q S++G+ S G S S ++L GQ +G+ + + G G Q
Sbjct: 1908 SRGE-----QHGSSSGSSSSYGQHGSGSRQSLGH-GQHGSGSGQSPSPSRGRHGSGSGQS 1961
Query: 527 RRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAK 586
P +G+ G S SR ++ G+ G G+++SR G + Q G ++ +
Sbjct: 1962 SSYGPYGSGS----GWSSSRGPYES---GSGHSSGLGHRESRSGQSSGYGQHGSSSGHSS 2014
Query: 587 TRG------GGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDA 640
T G G G A++G + S G + G+ S + P GQ+ +
Sbjct: 2015 THGQHGSASGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGH-GQRGS 2073
Query: 641 AAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDG 700
+ + + G GSG Q G S ++ + G
Sbjct: 2074 GSRQSP-SYGRHGSGSGRSSSSGQHGPGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSG 2132
Query: 701 -GQNAAVG--INPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGG----AKSRSGKKA 753
GQ+ + + +R G G G+ SR S G +GSG ++ R G +
Sbjct: 2133 YGQHGSRSGQSSRGERHGSSSGSSSRYGQHGSGSRQSSGHGRQGSGSGHSPSRGRHGSGS 2192
Query: 754 AASKSHG--GGGAKRRRGGGA-KSRSGEKAVTAGGQKAAAAG 792
S SHG G G+ R G +SRSG +V GQ + +G
Sbjct: 2193 GHSSSHGQHGSGSGRSSSRGPYESRSGHSSVF--GQHESGSG 2232
Score = 84.0 bits (206), Expect = 5e-16
Identities = 132/621 (21%), Positives = 224/621 (36%), Gaps = 89/621 (14%)
Query: 278 GQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAA 337
GQ+ + +G + + GRG G S GQ+P +G+ G + T +
Sbjct: 167 GQHNSYSGQSSSYGEQNSDSHQSSGRGQCGSGS--GQSPNYGQHGSGSGQSSSNDTHGSG 224
Query: 338 AGTKRG-----------------GGGQQKAAVVGVK-SRKKQRRRGKKPRRQKASAAGAK 379
+G G G G ++ G SR Q RG++ R S++
Sbjct: 225 SGQSSGFSQHKSSSGQSSGYSQHGSGSGHSSGYGQHGSRSGQSSRGERHRSSSGSSSSYG 284
Query: 380 SRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKS-- 437
G G ++ L ++ R+ P + + + G GS RG + S
Sbjct: 285 QHGSGSRQSLGHGRQGSGSRQSPSHVRHGSGSGHSSSHGQHGSGSSYSYSRGHYESGSGQ 344
Query: 438 --------RGGKSRSGGGKKPRRRGQKARQ-----------KAAEAGAESRGDKKQGRQK 478
G SG K G + Q + + G+ SR G+ +
Sbjct: 345 TSGFGQHESGSGQSSGYSKHGSGSGHSSSQGQHGSTSGQASSSGQHGSSSRQSSSYGQHE 404
Query: 479 ASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKS 538
+A S G G S GQ+ +G+ + ++G G + P V+G+
Sbjct: 405 --SASRHSSGRGQHSSGSGQSPGHGQRGSGSGQ-SPSSGQHGTGFGRSSSSGPYVSGS-G 460
Query: 539 RVGGSKSRQRQKAVAAGATSHGGG-------GNKQSRGGGGNKPRQWGQTAAAAKT---R 588
G + ++G T HG G G SR G ++ + G +A ++ +
Sbjct: 461 YSSGFGHHESSSEHSSGYTQHGSGSGHSSGHGQHGSRSGQSSRGERQGSSAGSSSSYGQH 520
Query: 589 GGGDKQP-GWQKAAAGVTKSRSGDGGK--KAWRQKAA------GTGAKSRKKPWRRGQKD 639
G G +Q G + +G +S S G+ RQ ++ G+G S + P+ G
Sbjct: 521 GSGSRQSLGHSRHGSGSGQSPSPSRGRHESGSRQSSSYGPHGYGSGRSSSRGPYESGSGH 580
Query: 640 AAAAEKAWATGATSRG-------SGGKQPRWQKPAAAGSESSAA--AAVGQEAEARKKPR 690
++ + S G SG Q + +G SS A ++ + +
Sbjct: 581 SSGLGHQESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGATSGQSSSHGQHG 640
Query: 691 RRRAKSRGDGGQNAAVGINPWQRR-----GKKPRLGK-SRGGGGAKSRGSGGAKSRGSG- 743
++S G Q + G +P + R G G+ G G + S G G+ S S
Sbjct: 641 SGSSQSSRYGQQGSGSGQSPSRGRHGSDFGHSSSYGQHGSGSGWSSSNGPHGSVSGQSSG 700
Query: 744 -GAKSRSGKKAAASK-----SHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPP 797
G KS SG+ + S+ SH G K G SRS + ++G +++ G+
Sbjct: 701 FGHKSGSGQSSGYSQHGSGSSHSSGYRKHGSRSGQSSRSEQHGSSSG---LSSSYGQHGS 757
Query: 798 RVKSRGGRGQKAAAGGKKPLR 818
G G++ + G P R
Sbjct: 758 GSHQSSGHGRQGSGSGHSPSR 778
Score = 80.1 bits (196), Expect = 8e-15
Identities = 169/844 (20%), Positives = 294/844 (34%), Gaps = 97/844 (11%)
Query: 53 GSGDKKLRRQ-KAAAGGKKARLRGQKGAVAGKE-ARQHWQKAAG--AGGAENRGGGEQKA 108
GSG ++ + +G + GQ G+ + +R H++ +G +G ++ G Q
Sbjct: 300 GSGSRQSPSHVRHGSGSGHSSSHGQHGSGSSYSYSRGHYESGSGQTSGFGQHESGSGQ-- 357
Query: 109 AAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKS 168
++G G +GQ + +G +A S GS +R + + +A S
Sbjct: 358 -SSGYSKHGSGSGHSSSQGQHGSTSG------QASSSGQHGSSSRQSSSYGQHESASRHS 410
Query: 169 QGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRP 228
G + Q ++ +G G++ G + G R + S + G
Sbjct: 411 SG--RGQHSSGSGQSPGHGQRGSGSGQSPSSGQHGTGFGRSSSSGPYVSGSGYSSGFGHH 468
Query: 229 KPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKS----RVGKSRGGGDKKLRRQGQNAALA 284
+ ++ + G GQ + G+S R G S G + +
Sbjct: 469 ESSSEHSSGYTQHGSGSGHSSGHGQHGSRSGQSSRGERQGSSAGSSSSYGQHGSGSRQSL 528
Query: 285 GAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAG----- 339
G R G+ + ++GR G + P G+ R ++ ++G
Sbjct: 529 GHSRHGSGSGQSPSPSRGRHESGSRQSSSYGPHGYGSGRSSSRGPYESGSGHSSGLGHQE 588
Query: 340 --TKRGGGGQQKAAVVGVKSRKKQR--RRGKKPR-RQKASAAGAKSRGGGDKKGLREAKR 394
+ + G Q + G S Q G+ Q + +G S G G ++ R
Sbjct: 589 SRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGATSGQSSSHGQHGSGSSQSSR 648
Query: 395 RGDGRKKPRWQNPRRRAQ-----KAPAAKPRGGGSKKPRRRGPKAAKSR-----GGKSRS 444
G + Q+P R + + G GS GP + S G KS S
Sbjct: 649 YGQ-QGSGSGQSPSRGRHGSDFGHSSSYGQHGSGSGWSSSNGPHGSVSGQSSGFGHKSGS 707
Query: 445 GGGKKPRRRGQKARQKAAEAGAESR-GDKKQGRQKASAAGTKSRGG--GLKSHSGKNLWR 501
G + G + + SR G + Q S++G S G G SH R
Sbjct: 708 GQSSGYSQHGSGSSHSSGYRKHGSRSGQSSRSEQHGSSSGLSSSYGQHGSGSHQSSGHGR 767
Query: 502 RGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKS--------RQRQKAVA 553
+G + + + S G Q + S G +S Q +
Sbjct: 768 QG--SGSGHSPSRVRHGSSSGHSSSHGQHGSGTSCSSSCGHYESGSGQASGFGQHESGSG 825
Query: 554 AGATSHG-GGGNKQSRGGGGNKPRQ----------------WGQTAAAAKTRGGGDKQPG 596
G + HG G+ S+G G+ Q +GQ +A+ G +
Sbjct: 826 QGYSQHGSASGHFSSQGRHGSTSGQSSSSGQHDSSSGQSSSYGQHESASHHASGRGRHGS 885
Query: 597 WQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAA----AEKAWATGAT 652
+ G + SG G ++ + +G+G S G ++ + ++G T
Sbjct: 886 GSGQSPGHGQRGSGSGQSPSYGRHGSGSGRSSSSGRHGSGSGQSSGFGHKSSSGQSSGYT 945
Query: 653 SRGSG-GKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSR---GDGGQNAAVGI 708
GSG G +++ + +SS + G + + + + SR G G + G
Sbjct: 946 QHGSGSGHSSSYEQHGSRSGQSSRSEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQ 1005
Query: 709 NPWQRRGK-------KPRLGKSRGGGG-AKSRG---SGGAKSRGSGGAKSRSGKKAAASK 757
+P RG+ G R G G + SRG SG S G G +SRSG+ + +
Sbjct: 1006 SPSPSRGRHGSGSGQSSSYGPYRSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQ 1065
Query: 758 SHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAG-----GKKPPRVKSRGGRGQKAAAG 812
HG G S SG+ ++ GQ A++G G+ G G++ +
Sbjct: 1066 -HGSSSGHSSTHGQHGSTSGQS--SSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGS 1122
Query: 813 GKKP 816
G+ P
Sbjct: 1123 GQSP 1126
Score = 75.9 bits (185), Expect = 1e-13
Identities = 121/602 (20%), Positives = 215/602 (35%), Gaps = 61/602 (10%)
Query: 53 GSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEAR--QHWQKAAGAGGAENRGGGEQKAAA 110
GSG Q + G +GQ G+ +G+ + Q + G G ++++
Sbjct: 2230 GSGHSSAYSQHGSGSGHFCS-QGQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSS 2288
Query: 111 AGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKS-- 168
G + G R R + S + + ++ S G+G+ +++ +S
Sbjct: 2289 YGQQGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSS 2348
Query: 169 -QGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRR 227
Q Q + +G S + R G SRG+ + G + S +G+ G R+
Sbjct: 2349 WQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGE--RHGSSSGSSSSYGQHGSGSRQ---- 2402
Query: 228 PKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAK 287
+ G + G G+ P R G+ + G+S G G +
Sbjct: 2403 ---SLGHGQHGSGSGQSPSPSR--GRHGSGSGQSSSYSPYGSGS------------GWSS 2445
Query: 288 RRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQ 347
RG +G ++ G G R +S GQ+ +G+ G + +G G
Sbjct: 2446 SRGPYESGSGHSS-GLGHRESRS--GQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCG-- 2500
Query: 348 QKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNP 407
Q A G S Q G ++S G + G G G +R R+ P +
Sbjct: 2501 QHGASSGQSSSHGQHGSGSS----QSSGYGRQGSGSGQSPG--HGQRGSGSRQSPSYGRH 2554
Query: 408 RRRAQKAPAAKPRGGGSKKPRRRGPKAAKS----------RGGKSRSGGGKKPRRRGQKA 457
+ ++ ++ G G + G + S G SG G+ R GQ +
Sbjct: 2555 GSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSS 2614
Query: 458 R--QKAAEAGAESR-GDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKAT 514
R + + +G+ S G G +++S G + G G G++ G + +
Sbjct: 2615 RGERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGQSPSRGRHGSGLGHSSSHGQHGSG 2674
Query: 515 AAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAG-ATSHGGGGNKQSRGGG-G 572
+ + SRG + R +V G G S Q +G S G G+ +
Sbjct: 2675 SGRSSSRGPYESRLGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFD 2734
Query: 573 NKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKS------RSGDGGKKAWRQKAAGTGA 626
+ GQ+++ G + G+ + AG +S SG G ++ Q +G+G
Sbjct: 2735 QEGSSTGQSSSYGHRGSGSSQSSGYGRHGAGSGQSLSHGRHGSGSGQSSSYGQHGSGSGQ 2794
Query: 627 KS 628
S
Sbjct: 2795 SS 2796
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 97.8 bits (242), Expect = 4e-20
Identities = 144/664 (21%), Positives = 250/664 (37%), Gaps = 99/664 (14%)
Query: 183 KSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRG-GRRKKHRRPKPAAGGAKSRRGG 241
K + KK + RG +S ++ R++ +K + ++ +++KHR P P KS+R
Sbjct: 186 KQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTP-----KSKR-- 238
Query: 242 GKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAK 301
K K+R+R + KSR D +A+ + R + +A K
Sbjct: 239 -KSKDKKRKRSRSTTPAPKSRRAHRSTSAD--------SASSSDTSRSRSRSAAAKTHTT 289
Query: 302 GRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQ 361
GR P +P GR G+ + T + + +Q ++ K + K+
Sbjct: 290 ALAGRSP------SPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKK 343
Query: 362 RRRGKKPRRQKASAAGAKSRGGGDKKGLRE--AKRRGDGRKKPRWQNPRRRAQKAPAAKP 419
+ +P S + +S G + A+R G G +P P + P ++
Sbjct: 344 EKSATRP-----SPSPERSSTGPEPPAPTPLLAERHG-GSPQPLATTPLSQEPVNPPSE- 396
Query: 420 RGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQG--RQ 477
+ R R P + + +S S P + K + A+ + + G R+
Sbjct: 397 ----ASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHRE 452
Query: 478 KASAAGTKSRGGGL----KSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAV 533
+S+ +K+R G KSHS R G+ + ATA +SR R +R
Sbjct: 453 ISSSPTSKNRSHGRAKRDKSHSHTPSRRMGR----SRSPATAKRGRSRSRTPTKR----- 503
Query: 534 AGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDK 593
G S+SR Q + A G + Q RG R +
Sbjct: 504 -------GHSRSRSPQWRRSRSAQRWGRSRSPQRRG------------------RSRSPQ 538
Query: 594 QPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKK-PWRRGQKDAAAAEKAWATGAT 652
+PGW ++ + RS + ++ T +SR + P RRG+ + + +
Sbjct: 539 RPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPAR---RRSR 595
Query: 653 SRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQ 712
SR ++ R + PA G S A + + P RRR++SR ++
Sbjct: 596 SRTPTRRRSRSRTPARRGRSRSRTPA--RRRSRTRSPVRRRSRSRSPARRSGRSRSRTPA 653
Query: 713 RRGKK-----PRLGKSRGGGGAKSRG---------SGGAKSRGSGGAKSRSGKKAAASKS 758
RRG+ R G+SR A+ G G ++SR +SRS +S
Sbjct: 654 RRGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRS 713
Query: 759 HGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGR---GQKAAAGGKK 815
H +R R G + R + + ++ ++ K R+ SR R ++ A +
Sbjct: 714 HSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRL 773
Query: 816 PLRR 819
LRR
Sbjct: 774 SLRR 777
Score = 90.1 bits (222), Expect = 7e-18
Identities = 129/601 (21%), Positives = 211/601 (35%), Gaps = 103/601 (17%)
Query: 70 KARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPR----R 125
K R R + A K R H +A + + + ++AAA T + GR P R
Sbjct: 243 KKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGR 302
Query: 126 RGQ----------------KAAATGSKKP--------RWRAQKSAAAGS---KNRGAGAQ 158
RG+ + T +K+P + + +KSA S + G +
Sbjct: 303 RGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPE 362
Query: 159 KAAAAAGVKSQGGEKPQKAA--------------AAGAKSRS-GKKPRRRGAKSRGDEDK 203
A + + G PQ A A+ + RS K P + S +
Sbjct: 363 PPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSP 422
Query: 204 KGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKS-- 261
Q SR + PKPA R K R G+ S
Sbjct: 423 PSPQPTKVSRHASS------SPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHT 476
Query: 262 ---RVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRG------PKSLG 312
R+G+SR K R R + + + R GR +S
Sbjct: 477 PSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRS 536
Query: 313 GQNPRWG-------RGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVG-----VKSRKK 360
Q P W RG + RRG+ +++ A RG + A G +R++
Sbjct: 537 PQRPGWSRSRNTQRRGRSRSARRGRSHSRSPAT---RGRSRSRTPARRGRSRSRTPARRR 593
Query: 361 QRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPR 420
R R RR ++ + R R ++ R R++ R ++P RR+ ++ + P
Sbjct: 594 SRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPA 653
Query: 421 GGG---SKKPRRRGPKAAKS---RGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQ 474
G S+ P RRG +++ R G+SRS + P RRG+ + + SR ++
Sbjct: 654 RRGRSRSRTPARRGRSRSRTPARRSGRSRS---RTPARRGRSRSRTPRRGRSRSRSLVRR 710
Query: 475 GRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAG-----EKATAAGAKSRGRKQPRRQ 529
GR + + R G S KN R Q+ + +K+ + +SR PR +
Sbjct: 711 GRSHSRTPQRRGRSG--SSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSK 768
Query: 530 KPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGN---------KQSRGGGGNKPRQWGQ 580
+ + + GS +QK+ S G ++SR P+Q +
Sbjct: 769 AKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSK 828
Query: 581 T 581
T
Sbjct: 829 T 829
Score = 85.5 bits (210), Expect = 2e-16
Identities = 154/784 (19%), Positives = 275/784 (35%), Gaps = 108/784 (13%)
Query: 100 NRGGGEQKAAAAGTKS--LGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGA 157
N E+ AA G + G P+RR ++A + P+ + ++ S++
Sbjct: 128 NEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQ 187
Query: 158 QKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKT 217
+K K G + + ++ + +S KK + R + +K R KS+ K+
Sbjct: 188 KKKKK----KKDRGRRSESSSPRRERKKSSKKKKHRSESE--SKKRKHRSPTPKSK-RKS 240
Query: 218 RGGRRKKHRRPKPAAGGAKSRRG------GGKKPQKQRRRGQKAATGGKSRVGKS----- 266
+ +RK+ R PA ++ R + R R A T + G+S
Sbjct: 241 KDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPAS 300
Query: 267 --RGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKK 324
RG GD G + + A P + KS +P R
Sbjct: 301 GRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTG 360
Query: 325 PRRRGQKATKAAAAGTKRGGGGQQKAAVVGVK----------SRKKQRRRGKKPRRQKAS 374
P A +R GG Q A + S + R K P + S
Sbjct: 361 PEPPAPTPLLA-----ERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQS 415
Query: 375 AAGAKSRGGGDK-KGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPK 433
++ S K R A + K R +P +K R G K +
Sbjct: 416 SSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSH 475
Query: 434 AAKSRGGKSRSGGGKK--------PRRRG-------QKARQKAAEAGAESRGDKKQGRQK 478
R G+SRS K P +RG Q R ++A+ SR +++GR +
Sbjct: 476 TPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSR 535
Query: 479 AS-------AAGTKSRGGGLKSHSGKNLWR----RGQKAEAAGEKATAAGAKSRGRKQPR 527
+ + T+ RG + G++ R RG+ + + +++ R++ R
Sbjct: 536 SPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSR 595
Query: 528 RQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGG---------GNKPRQW 578
+ P ++SR + R R + A + ++SR P +
Sbjct: 596 SRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARR 655
Query: 579 GQTAAAAKTRGGGDK------QPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSR--- 629
G++ + R G + + G ++ + RS + R ++ + R
Sbjct: 656 GRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHS 715
Query: 630 KKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKP 689
+ P RRG+ +++ K + + R P +K + S + ++ +A++R
Sbjct: 716 RTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSL 775
Query: 690 RRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGG---AKSRGSGGAKSRGSGGAK 746
RR + S P Q+ PR +SR G AKSR + +SR S
Sbjct: 776 RRSLSGSSPC----------PKQKSQTPPR--RSRSGSSQPKAKSR-TPPRRSRSSSSPP 822
Query: 747 SRSGKKAAASKSHGG--------GGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPR 798
+ K + +SH G R+G ++ E++VT Q+ + P
Sbjct: 823 PKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTP--QRRSCFESSPDPE 880
Query: 799 VKSR 802
+KSR
Sbjct: 881 LKSR 884
Score = 79.3 bits (194), Expect = 1e-14
Identities = 126/607 (20%), Positives = 223/607 (36%), Gaps = 61/607 (10%)
Query: 116 LGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQ 175
LG R R Q+ S P+ R++ ++ SK K +S+ G P+
Sbjct: 1533 LGQRSRSGS--SQELDVKPSASPQERSESDSSPDSK------AKTRTPLRQRSRSGSSPE 1584
Query: 176 ---KAAAAGAKSRSGKKPRRRG-------AKSRGDEDKKGRQREAKSRFGKTRGGRRKKH 225
K+ + +SRSG P + A+S D + + ++ ++R G K
Sbjct: 1585 VDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKG 1644
Query: 226 RRPKPAAGGAKSRRGGGKKPQKQR--RRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAAL 283
R P P G+ S + P K R RRG +++ K+ KSR ++ R
Sbjct: 1645 RGPSPE--GSSSTESSPEHPPKSRTARRGSRSSPEPKT---KSRTPPRRRSSRSSPELTR 1699
Query: 284 AGAKRRGAATAGEKPAAKGR-GGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKR 342
R + +A P + R R +S +P + RRR ++ ++R
Sbjct: 1700 KARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRR 1759
Query: 343 GGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKP 402
G K R QR R + RR+K + R G + ++RR R +
Sbjct: 1760 GRSPSP-------KPRGLQRSRSRS-RREKTRTTRRRDRSGSSQS---TSRRRQRSRSRS 1808
Query: 403 RWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAA 462
R RR G S+ P R+ SR + RS R+R + A
Sbjct: 1809 RVTRRRRGGS--------GYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAP 1860
Query: 463 EAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRG 522
+ SR R+ S SR +S + RR + + + + + A
Sbjct: 1861 WKRSRSRASPATHRRSRSRTPLISRRRS-RSRTSPVSRRRSRSRTSVTRRRSRSRASPVS 1919
Query: 523 RKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGG--------NKQSRGGGGNK 574
R++ R + P V +SR +R+R ++ T +SR +
Sbjct: 1920 RRRSRSRTPPVTRRRSRSRTPTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITR 1979
Query: 575 PRQWGQTAAAAKTRGGGDKQPGWQKAA----AGVTKSRSGDGGKKAWRQKAAGTGAKSRK 630
R +T+ + R P ++ + + VT+ RS A R+++ +++
Sbjct: 1980 RRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSR---SRTPL 2036
Query: 631 KPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPR 690
P +R + + A + + T R + GK+ + P A S++ ++ + A
Sbjct: 2037 LPRKRSRSRSPLAIRRRSRSRTPRTARGKRSLTRSPPAIRRRSASGSSSDRSRSATPPAT 2096
Query: 691 RRRAKSR 697
R + SR
Sbjct: 2097 RNHSGSR 2103
Score = 77.0 bits (188), Expect = 6e-14
Identities = 98/445 (22%), Positives = 177/445 (39%), Gaps = 62/445 (13%)
Query: 58 KLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLG 117
+ +R K+ + R+ + K R + G + +R +++ +A
Sbjct: 466 RAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSA---QRW 522
Query: 118 GRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKA 177
GR R P+RRG+ + ++P W ++ ++R A + G ++
Sbjct: 523 GRSRSPQRRGRSRSP---QRPGWSRSRNTQRRGRSRSA-------------RRGRSHSRS 566
Query: 178 AAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKS 237
A +SRS RR ++SR ++ R R R ++R R+ R + A
Sbjct: 567 PATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPA----R 622
Query: 238 RRGGGKKPQKQRRRGQK-AATGGKSRVGKSRGGGDKKLR---RQGQNAALAGAKRRGAAT 293
RR + P ++R R + A G+SR G + R R+G++ + A+R G +
Sbjct: 623 RRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSR 682
Query: 294 AGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPR-RRGQKATKAAAAGTKRGGGGQQKAAV 352
+ PA +GR + PR GR + RRG+ ++ + G ++K
Sbjct: 683 S-RTPARRGRS-------RSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKN-- 732
Query: 353 VGVKSRKKQR--RRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQN--PR 408
KSR QR R P +K+ + +SR + +AK R R+ + P+
Sbjct: 733 ---KSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRS--KAKSRLSLRRSLSGSSPCPK 787
Query: 409 RRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAES 468
+++Q P G K + R P +SRS P+ QK++ + ++ + S
Sbjct: 788 QKSQTPPRRSRSGSSQPKAKSRTPPR------RSRSSSSPPPK---QKSKTPSRQSHSSS 838
Query: 469 RGDKKQGRQKASAAGTKSRGGGLKS 493
K +GT R G + S
Sbjct: 839 SPHPK------VKSGTPPRQGSITS 857
Score = 72.4 bits (176), Expect = 2e-12
Identities = 131/657 (19%), Positives = 237/657 (36%), Gaps = 54/657 (8%)
Query: 54 SGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGT 113
S + +R+ + ++ R + A G R + A G + +R +++ +
Sbjct: 543 SRSRNTQRRGRSRSARRGRSHSRSPATRG---RSRSRTPARRGRSRSRTPARRRSRSRTP 599
Query: 114 KSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEK 173
R R P RRG+ + T +++ R R + S++R + + + ++ G
Sbjct: 600 TRRRSRSRTPARRGRSRSRTPARR-RSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRS 658
Query: 174 PQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRG----GRRKKHRRPK 229
+ A +SRS RR G ++GR R R G++R R + H R
Sbjct: 659 RSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTP 718
Query: 230 PAAG--GAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGG-----DKKLRRQGQNAA 282
G G+ S R + ++R R + KSR+ R K R +
Sbjct: 719 QRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRS 778
Query: 283 LAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKR 342
L+G+ + P G PK+ PR R P + + T + + +
Sbjct: 779 LSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSS 838
Query: 343 GGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKP 402
+ VKS R+ + + + R + E K R R
Sbjct: 839 SPHPK-------VKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSC 891
Query: 403 RWQNPRR-RAQKAPAAKPRGGGSKKPRRR---GPKAAKSRGGKSRSGGGKKPRRRGQKAR 458
+P R ++ P P S +P+ + P+ G S S R +++R
Sbjct: 892 SGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSR 951
Query: 459 QKAAEAGAESRGDKKQGRQKASAAGTKSR--GGGLKSHSGKNLWRRGQKAEAAGEKATAA 516
+ + ESR + +S+ TK + +SHSG KA+ T
Sbjct: 952 SVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQ------TPP 1005
Query: 517 GAKSRGRKQPRRQKPAVAGAKSRVGGSKSR-QRQKAVAAGATSHGGGGNKQSRGGGGNKP 575
G G K P Q+ + GS S K+ S+ G + Q +G P
Sbjct: 1006 GPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSP 1065
Query: 576 RQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRR 635
T ++ + R + P Q +KS++ G ++ R + T SR P R+
Sbjct: 1066 DHRSDT-SSPEVRQSHSESPSLQ------SKSQTSPKGGRS-RSSSPVTELASR-SPIRQ 1116
Query: 636 GQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQE----AEARKK 688
+ + +A+ G +Q R+Q +++ + + +GQ AE+++K
Sbjct: 1117 DRGEFSASP------MLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEK 1167
Score = 70.9 bits (172), Expect = 5e-12
Identities = 131/716 (18%), Positives = 270/716 (37%), Gaps = 90/716 (12%)
Query: 105 EQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSK----------NRG 154
E+ ++A+ + G R P RR + ++ G + + + +GS +RG
Sbjct: 1417 ERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRG 1476
Query: 155 AGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQRE---AK 211
++ Q ++ ++ + P+R + S D+K R +
Sbjct: 1477 RSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQR 1536
Query: 212 SRFGKTRGGRRKKHRRP--KPAAGGAKSRRGGGKKPQKQR-RRGQKAATGGKSRVG--KS 266
SR G ++ K P + + + + + P +QR R G KSR+ +S
Sbjct: 1537 SRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRS 1596
Query: 267 RGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPR 326
R G +++ + + A + + + + +P A +S G + + G+ P
Sbjct: 1597 RSGSSPEVKDKPR----AAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSK----GRGPS 1648
Query: 327 RRGQKATKAA---AAGTKRGGGGQQKAAVVGVKSRKKQRRRGKK-----------PRRQK 372
G +T+++ ++ G + + KSR RRR + RR +
Sbjct: 1649 PEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSR 1708
Query: 373 ASAAGAKSRGGGDKKGLR-------------EAKRRGDGRKKPRWQNPRRRAQKAPAAKP 419
++++ ++R + R + RR PR + RR ++P+ KP
Sbjct: 1709 SASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRG-RSPSPKP 1767
Query: 420 RGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKA----AEAGAESRGDKKQG 475
RG + R R K +R + RSG + RR Q++R ++ G +
Sbjct: 1768 RGLQRSRSRSRREKTRTTR-RRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPA 1826
Query: 476 RQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAG 535
RQ++S ++ R G ++ R + + A +++ + + + R+ R + P ++
Sbjct: 1827 RQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRS-RSRTPLISR 1885
Query: 536 AKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQP 595
+SR S +R+ T +SR ++ R +T + R
Sbjct: 1886 RRSRSRTSPVSRRRSRSRTSVTRR----RSRSRASPVSRRRSRSRTPPVTRRR------- 1934
Query: 596 GWQKAAAGVTKSRSGDGGKKAWRQKA-AGTGAKSRKKPWRRGQKDAAAAEKAWATGATSR 654
++ T+ RS R+++ + T +R++ R ++ + T R
Sbjct: 1935 --SRSRTPTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRR 1992
Query: 655 GSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPR-RRRAKSRGD------GGQNAAVG 707
S + R S S + + + +R P RRR++SR + +
Sbjct: 1993 RS---RSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLA 2049
Query: 708 INPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAA--ASKSHGG 761
I RR + R ++ G + +R + R + G+ S + A A+++H G
Sbjct: 2050 I----RRRSRSRTPRTARGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSG 2101
Score = 61.2 bits (147), Expect = 4e-09
Identities = 108/548 (19%), Positives = 203/548 (37%), Gaps = 63/548 (11%)
Query: 6 HRQCNQAAGRAGPGAPLGAALARTPVELAAESAAPALSAAAAGVKILGSGDKKLRRQKAA 65
H ++ A R +P +RTP + ++P L+ A + RR ++A
Sbjct: 1661 HPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKA----------RLSRRSRSA 1710
Query: 66 AGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAG---TKSLGGRGRK 122
+ + R R R+ ++ ++R +++A++ T S GR
Sbjct: 1711 SSSPETRSR------TPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPS 1764
Query: 123 PRRRGQKAAATGSKKPRWRA----QKSAAAGSKNRGAGAQKAAAAAGVKSQGGEK-PQKA 177
P+ RG + + + S++ + R +S ++ S +R ++ + + +GG ++
Sbjct: 1765 PKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRS 1824
Query: 178 AAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKS 237
A SR+ + RR +++ K+ R R + + + +R + A A
Sbjct: 1825 PARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPW-----------KRSRSRASPATH 1873
Query: 238 RRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEK 297
RR + P RRR + + R +SR RR+ ++ A ++RR +
Sbjct: 1874 RRSRSRTPLISRRRSRSRTSPVSRRRSRSR---TSVTRRRSRSRASPVSRRR---SRSRT 1927
Query: 298 PAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKS 357
P R R + R R RRR + T T+R + ++ +
Sbjct: 1928 PPVTRRRSRSRTPTTRRRSR-SRTPPVTRRRSRSRTPPV---TRR----RSRSRTSPITR 1979
Query: 358 RKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAA 417
R+ + R RR+ S +R + +RR R P RRR++
Sbjct: 1980 RRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPA---IRRRSRSRTPL 2036
Query: 418 KPRGGGSKKPRRRGPKA--AKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQG 475
PR K+ R R P A +SR R+ GK+ R A ++ + +G+ S
Sbjct: 2037 LPR----KRSRSRSPLAIRRRSRSRTPRTARGKRSLTRSPPAIRRRSASGSSS-----DR 2087
Query: 476 RQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAG 535
+ A+ T++ G N R + + +S G +P
Sbjct: 2088 SRSATPPATRNHSGSRTPPVALNSSRMSCFSRPSMSPTPLDRCRSPGMLEPLGSSRTPMS 2147
Query: 536 AKSRVGGS 543
+ GGS
Sbjct: 2148 VLQQAGGS 2155
Score = 60.8 bits (146), Expect = 5e-09
Identities = 91/469 (19%), Positives = 168/469 (35%), Gaps = 28/469 (5%)
Query: 366 KKPRRQKASAAGAKSRGGG--------DKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAA 417
+ P R+++S+A + G + G R G G + K
Sbjct: 1412 RTPSRERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPR 1471
Query: 418 KPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQ 477
P G S+ PKA + RS P + + +G+ES D+K +
Sbjct: 1472 TPSRGRSECDSSPEPKALPQTP-RPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVAR 1530
Query: 478 KASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAK 537
+ G +SR G + K +++E+ + A ++ R++ R +K
Sbjct: 1531 --TPLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSK 1588
Query: 538 SRVGGSKSRQ------RQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGG 591
SR+ +SR + K AA G + + + + ++ +++K RG
Sbjct: 1589 SRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPS 1648
Query: 592 DK-QPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATG 650
+ + + KSR+ G ++ + KSR P RR + + +
Sbjct: 1649 PEGSSSTESSPEHPPKSRTARRGSRSSPEPKT----KSRTPPRRRSSRSSPELTRKARLS 1704
Query: 651 ATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINP 710
SR S P + S + + + AE + RRRR+ S + G +P
Sbjct: 1705 RRSR-SASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSP 1763
Query: 711 WQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGG 770
KPR G R ++ + + R G+ + ++ S+S +RR G
Sbjct: 1764 ----SPKPR-GLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGS 1818
Query: 771 GAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGRGQKAAAGGKKPLRR 819
G SRS + ++ G + P + R + + A K+ R
Sbjct: 1819 GYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSR 1867
Score = 55.1 bits (131), Expect = 3e-07
Identities = 99/496 (19%), Positives = 183/496 (36%), Gaps = 55/496 (11%)
Query: 366 KKPRRQKASAAGAKSRGGGD----KKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRG 421
KK R +A+ + S G ++ REAK+ KP + ++P K +
Sbjct: 130 KKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKK 189
Query: 422 GGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESR---GDKKQGRQK 478
KK R R +++ R + +S KK R + ++K +S+ DKK+ R +
Sbjct: 190 KKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSR 249
Query: 479 ASAAGTKS----RGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRR------ 528
++ KS R S S + R ++ AA TA +S RR
Sbjct: 250 STTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAP 309
Query: 529 ---------QKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWG 579
Q+P+ ++ S + K + + ++S G P
Sbjct: 310 FSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTG----PEPPA 365
Query: 580 QTAAAAKTRGGG---------DKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRK 630
T A+ GG ++P + A T+ RS + Q ++ +
Sbjct: 366 PTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSP 425
Query: 631 KPWRRGQKDAAAAEK---AWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARK 687
+P + + +++ E A A G+ S + + A + S + + +
Sbjct: 426 QPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSR 485
Query: 688 KP---RRRRAKSRGDGGQNAAVGINP-WQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSG 743
P +R R++SR + + +P W+R R G+SR + RG + R G
Sbjct: 486 SPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSR---SPQRRGRSRSPQR-PG 541
Query: 744 GAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRG 803
++SR+ ++ S+S G R + RS + G+ + + P R +SR
Sbjct: 542 WSRSRNTQRRGRSRS-ARRGRSHSRSPATRGRSRSRTPARRGRSRS----RTPARRRSRS 596
Query: 804 GRGQKAAAGGKKPLRR 819
+ + + P RR
Sbjct: 597 RTPTRRRSRSRTPARR 612
Score = 54.3 bits (129), Expect = 4e-07
Identities = 91/493 (18%), Positives = 175/493 (35%), Gaps = 34/493 (6%)
Query: 356 KSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAP 415
++R+ ++ + P+ + SR K+ ++ K++ D ++ +PRR +K+
Sbjct: 156 RAREAKQPAPEPPKPYSLVRESSSSRSPTPKQ--KKKKKKKDRGRRSESSSPRRERKKSS 213
Query: 416 AAKPRGGGS--KKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKK 473
K S KK + R P R K + + K+R+ A+S
Sbjct: 214 KKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSD 273
Query: 474 QGRQKASAAGTKSRGGGLKSHS-GKNLWRRGQKAEAAGEKATAA----GAKSRGRKQP-- 526
R ++ +A K+ L S RRG+ E T + + KQP
Sbjct: 274 TSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSS 333
Query: 527 --------RRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQW 578
+++K A + S S + A HGG + +P
Sbjct: 334 PYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNP 393
Query: 579 GQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQK 638
A+ + R ++++ + S K + ++ K P +
Sbjct: 394 PSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREI 453
Query: 639 DAAAAEKAWATGATSRGS------GGKQPRWQKPAAAGSESSAAAAVGQEAEAR-KKPRR 691
++ K + G R + R + PA A S + + +R + P+
Sbjct: 454 SSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQW 513
Query: 692 RRAKSRGDGGQNAAVGINPWQRRGKKPRLGKS-----RGGGGAKSRGSGGAKSRGSGGAK 746
RR++S G++ + R ++P +S RG + RG ++S + G +
Sbjct: 514 RRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRG-R 572
Query: 747 SRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGRG 806
SRS A +S A+RR +R ++ T + + + P R +SR
Sbjct: 573 SRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPA--RRGRSRSRTPARRRSRTRSP 630
Query: 807 QKAAAGGKKPLRR 819
+ + + P RR
Sbjct: 631 VRRRSRSRSPARR 643
Score = 52.0 bits (123), Expect = 2e-06
Identities = 84/457 (18%), Positives = 166/457 (36%), Gaps = 47/457 (10%)
Query: 356 KSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKR---RG--------DGRKKPRW 404
++ ++ R G P + S ++ G G+++ R RG + + P+
Sbjct: 1433 RTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQT 1492
Query: 405 QNPRRRAQKAPAA--------KPRGGGS----KKPRRRGPKAAKSRGGKSRSGGGK---K 449
PR R+ +P + R G +K R P +SR G S+ K
Sbjct: 1493 PRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSAS 1552
Query: 450 PRRRGQKARQKAAEAGAESRGDKKQGRQKASA--AGTKSRGGGLKSHSGKNLWRRGQKAE 507
P+ R + + ++ A++R +Q + S+ +KSR +S SG + + +
Sbjct: 1553 PQERSES--DSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSS-----PEVK 1605
Query: 508 AAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQS 567
A A + S +P+ P +SR G S + + +T +S
Sbjct: 1606 DKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKS 1665
Query: 568 RGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTG-- 625
R R+ +++ KT+ + +++ +T+ + + R ++A +
Sbjct: 1666 RTA-----RRGSRSSPEPKTKSRTPPRRRSSRSSPELTRK-----ARLSRRSRSASSSPE 1715
Query: 626 AKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEA 685
+SR P R ++ E A + ++ R PR + + G S Q + +
Sbjct: 1716 TRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRS 1775
Query: 686 RKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGA 745
R + + R R D ++ QR + R+ + R GG S + +
Sbjct: 1776 RSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSS 1835
Query: 746 KSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVT 782
+ R G+ S ++ +SRS T
Sbjct: 1836 RRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPAT 1872
Score = 37.0 bits (84), Expect = 0.074
Identities = 29/138 (21%), Positives = 59/138 (42%), Gaps = 10/138 (7%)
Query: 123 PRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAA-AG 181
P +R ++++++ S + S+++ S + + + +++++ S P K A
Sbjct: 2600 PAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQAL 2659
Query: 182 AKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKP--------AAG 233
K S KKP +SR R+++S + RR+ +P P G
Sbjct: 2660 PKPASPKKPPPGERRSRSPRKPIDSLRDSRS-LSYSPVERRRPSPQPSPRDQQSSSSERG 2718
Query: 234 GAKSRRGGGKKPQKQRRR 251
+ +RG + P +RRR
Sbjct: 2719 SRRGQRGDSRSPSHKRRR 2736
Score = 33.5 bits (75), Expect = 0.82
Identities = 102/510 (20%), Positives = 169/510 (33%), Gaps = 63/510 (12%)
Query: 286 AKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGG 345
A R A A A R P ++ +PR G + A AA + G G
Sbjct: 2257 ADSRTPAAAAAMNLASPRTAVAPSAVNLADPRTPTA-PAVNLAGARTPAALAALSLTGSG 2315
Query: 346 GQQKAAVVGVKSRKKQRRRGKK---PRRQKASA----AGAKSRGGGDKKGLREAKRRGDG 398
AA SR Q PR A+A AG+++ L A
Sbjct: 2316 TPPTAANYPSSSRTPQAPASANLVGPRSAHATAPVNIAGSRTAAALAPASLTSA------ 2369
Query: 399 RKKPRWQNPRRRAQKAP-AAKPRGGGSKKP------RRRGPKAAKSRGGKSRSGGGKKPR 451
R P + + P +A R G P R R P +A S+ +
Sbjct: 2370 RMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPSAPSQSRMTSERAPSPSS 2429
Query: 452 RRGQKARQ----------KAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKS-------- 493
R GQ Q ++ A S + Q AG++S G +
Sbjct: 2430 RMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGD 2489
Query: 494 HSGK-NLWRRGQKAEAAGEKATAAGAK---SRGRKQPRRQKPAVAGAKSRVGGSKSRQRQ 549
H+G ++ G GE + GA+ + QP +++ +S S S
Sbjct: 2490 HNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAKER------RSSSSSSSSSSSS 2543
Query: 550 KAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRS 609
+ ++ ++S G+ S G + P Q A K P K A +
Sbjct: 2544 SSSSSSSSSSSSSGSSSSDSEGSSLPVQ---PEVALKRVPSPTPAP---KEAVREGRPPE 2597
Query: 610 GDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAA 669
K+ R ++ + + S ++++ + ++ ++S S P KP
Sbjct: 2598 PTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQ 2657
Query: 670 GSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGA 729
A+ E R + R+ S D + ++ +P +RR P+ +
Sbjct: 2658 ALPKPASPKKPPPGERRSRSPRKPIDSLRD---SRSLSYSPVERRRPSPQPSPRDQQSSS 2714
Query: 730 KSRGSGGAKSRGS-GGAKSRSGKKAAASKS 758
RGS RG G ++S S K+ + S
Sbjct: 2715 SERGS----RRGQRGDSRSPSHKRRRETPS 2740
Score = 33.1 bits (74), Expect = 1.1
Identities = 28/151 (18%), Positives = 55/151 (36%), Gaps = 27/151 (17%)
Query: 122 KPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKP------- 174
K +RR ++++ S + S+++ S + + + +++++ S KP
Sbjct: 2602 KRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPK 2661
Query: 175 ----QKAAAAGAKSRSGKKP----------------RRRGAKSRGDEDKKGRQREAKSRF 214
+K +SRS +KP RRR + D++ E SR
Sbjct: 2662 PASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRR 2721
Query: 215 GKTRGGRRKKHRRPKPAAGGAKSRRGGGKKP 245
G+ R H+R + R + P
Sbjct: 2722 GQRGDSRSPSHKRRRETPSPRPMRHRSSRSP 2752
Score = 32.3 bits (72), Expect = 1.8
Identities = 102/563 (18%), Positives = 170/563 (30%), Gaps = 82/563 (14%)
Query: 16 AGPGAPLGAALARTPVELAAESAAPALSAAAAGVKILGSGDKKLRRQKAAAGGKKARLRG 75
A A + A ARTP A + A + + AAA L S R
Sbjct: 2234 AASAAAMNLASARTPAIPTAVNLADSRTPAAAAAMNLAS----------------PRTAV 2277
Query: 76 QKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGS 135
AV + R A GA + AA SL G G P T +
Sbjct: 2278 APSAVNLADPRTPTAPAVNLAGA-------RTPAALAALSLTGSGTPP---------TAA 2321
Query: 136 KKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGA 195
P A A + G + A A + G + A A + + + P GA
Sbjct: 2322 NYPSSSRTPQAPASANLVGPRSAHATAPVNI---AGSRTAAALAPASLTSARMAPALSGA 2378
Query: 196 KSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKA 255
G+T + R P + ++SR + P R GQ
Sbjct: 2379 NLTSPRVPLSAYERVS---GRTSPPLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAP 2435
Query: 256 ATG------GKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPK 309
+ + R D+ Q +AG++ + ++ G G
Sbjct: 2436 SQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAG-DHNGML 2494
Query: 310 SLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPR 369
S+ G+ P A T G QQ +A+ ++ K++R
Sbjct: 2495 SVPAPGVPHSDVGEPP------------AST----GAQQPSALAALQPAKERRSSSSSSS 2538
Query: 370 RQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRR 429
+S++ + S G + G P ++ P+ P
Sbjct: 2539 SSSSSSSSSSSSSSSSSSGSSSSDSEGSSLP----VQPEVALKRVPSPTP---------- 2584
Query: 430 RGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGG 489
PK A G K+ RR + ++ + + S +S++ + S
Sbjct: 2585 -APKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2643
Query: 490 GLKSHSGKNLWRRGQKA--EAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQ 547
S S + + G +A + A K G R + PR+ ++ ++S R+
Sbjct: 2644 --SSSSSPSPAKPGPQALPKPASPKKPPPG--ERRSRSPRKPIDSLRDSRSLSYSPVERR 2699
Query: 548 RQKAVAAGATSHGGGGNKQSRGG 570
R + + SR G
Sbjct: 2700 RPSPQPSPRDQQSSSSERGSRRG 2722
>gi|60097902 filaggrin [Homo sapiens]
Length = 4061
Score = 96.3 bits (238), Expect = 1e-19
Identities = 146/754 (19%), Positives = 269/754 (35%), Gaps = 87/754 (11%)
Query: 64 AAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKP 123
+A +++ R + + G+ A H Q + G E G G Q++A + S GRG
Sbjct: 349 SADSSRQSGTRHAETSSRGQTASSHEQARSSPG--ERHGSGHQQSADSSRHSATGRG--- 403
Query: 124 RRRGQKAAATGSKKPRWRAQKSAAAG-SKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGA 182
+ A + + +Q S + G S+N + AG++ Q ++ + +
Sbjct: 404 --QASSAVSDRGHRGSSGSQASDSEGHSENSDTQSVSGHGKAGLRQQSHQESTRGRSGER 461
Query: 183 KSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGG 242
RSG + + D A R G + GGR+ H + R
Sbjct: 462 SGRSGSSLYQVSTHEQPD--------SAHGRTGTSTGGRQGSHH---------EQARDSS 504
Query: 243 KKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKG 302
+ Q + G SR G+ ++ + R G +G+ + G A+
Sbjct: 505 RHSASQEGQDTIRGHPGSSRGGRQGSHHEQSVNRSGH----SGSHHSHTTSQGRSDASH- 559
Query: 303 RGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQR 362
G+ G + R + + + GT+ G +A+ SR Q
Sbjct: 560 ----------------GQSGSRSASRQTRNEEQSGDGTRHSGSRHHEASSQADSSRHSQV 603
Query: 363 RRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGG 422
+G+ S+ SR G +++ +G RW R A +
Sbjct: 604 GQGQ-------SSGPRTSRNQGSSVS-QDSDSQGHSEDSERWSGSASRNHHGSAQEQSRD 655
Query: 423 GSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAA 482
GS+ PR + R G S R+ G + Q ++ A S + Q S+A
Sbjct: 656 GSRHPRSH----HEDRAGHGHSADSS--RKSGTRHTQNSSSGQAASSHE-----QARSSA 704
Query: 483 GTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGG 542
G + H ++ + Q A+++ T G S + + + + A G
Sbjct: 705 GER--------HGSRH---QLQSADSSRHSGTGHGQASSAVRDSGHRGSSGSQATDSEGH 753
Query: 543 SKSRQRQKAVAAGATSHGGGGNKQS-RGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAA 601
S+ Q G H +++S R G + R+ G T + GW +
Sbjct: 754 SEDSDTQSVSGHGQAGHHQQSHQESARDRSGERSRRSGSFLYQVSTHKQSESSHGWTGPS 813
Query: 602 AGVTKSRSGDGGKKAWRQKAAGTGAKS-RKKPW--RRGQKDAAAAEKAWATGATSRGSGG 658
GV + + + R A+ G + R P RRG++ + + +G +
Sbjct: 814 TGVRQGSHHEQARDNSRHSASQDGQDTIRGHPGSSRRGRQGSHHEQSVDRSGHSGSHHSH 873
Query: 659 KQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKP 718
+ + A+ G S +A + + + R SR G ++ + R +
Sbjct: 874 TTSQGRSDASRGQSGSRSA-----SRTTRNEEQSRDGSRHSGSRHHEASSHADISRHSQA 928
Query: 719 RLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGK-KAAASKSHGGGGAKRRRGGGAKSRSG 777
G+S G ++ +GS ++ S G S + +AS++H G ++ R G RS
Sbjct: 929 GQGQSEGSRTSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSAQEQSRHGSRHPRSH 988
Query: 778 EKAVTAGGQKAAAAGGKKPPRVKSRGGRGQKAAA 811
+ G A ++ P ++ G GQ A++
Sbjct: 989 HEDRAGHGHSADSSRQSGTPHAETSSG-GQAASS 1021
Score = 89.7 bits (221), Expect = 1e-17
Identities = 163/852 (19%), Positives = 304/852 (35%), Gaps = 138/852 (16%)
Query: 60 RRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAA--------A 111
R + ++GG+ A Q + AG+ H Q++A + G G+ +A +
Sbjct: 2953 RHTQTSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGYS 3012
Query: 112 GTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGA------QKAAAAAG 165
G+++ G Q +A G ++ + +A G +G Q +
Sbjct: 3013 GSQASDNEGHSEDSDTQSVSAHGQAGSHQQSHQESARGRSGETSGHSGSFLYQVSTHEQS 3072
Query: 166 VKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKH 225
S G P G++ + R A G + +G G +RGGR+ H
Sbjct: 3073 ESSHGWTGPSTRGRQGSRHEQAQDSSRHSASQYGQDTIRGHP-------GSSRGGRQGYH 3125
Query: 226 RRPKPAAGG--------------AKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSR---G 268
+ G + + RG R + +G SR SR
Sbjct: 3126 HEHSVDSSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDSSRHSVSRHHEA 3185
Query: 269 GGDKKLRR-----QGQNAALAGAKRRGAATAGE-------KPAAKGRGGRGPKSLGGQNP 316
+ R QGQ+ ++R+G++ + + + + + G G
Sbjct: 3186 STHADISRHSQAVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSVQE 3245
Query: 317 RWGRGGKKPRRR-------GQKATKAAAAGTKRG---GGGQQKAAVVGVKSRKKQR---- 362
+ G + PR G A ++ +GT+ GGQ ++ +S +R
Sbjct: 3246 QSRHGSRHPRSHHEDRAGHGHSADRSRQSGTRHAETSSGGQAASSHEQARSSPGERHGSR 3305
Query: 363 --------RRGKKPRRQKASAA------GAKSRGGGDKKGLREAKRR----GDGRKKPRW 404
R PR Q +SA G+ D +G E G G+ P
Sbjct: 3306 HQQSADSSRHSGIPRGQASSAVRDSRHWGSSGSQASDSEGHSEESDTQSVSGHGQAGPHQ 3365
Query: 405 QNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEA 464
Q+ + A+ + GS + + ++S G++R+ G++ ++AR + +
Sbjct: 3366 QSHQESARDRSGGRSGRSGSFLYQVSTHEQSESAHGRTRTSTGRRQGSHHEQARDSSRHS 3425
Query: 465 GAESR--------GDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAA 516
++ G ++GRQ + + R G SH +G+ + G+ +
Sbjct: 3426 ASQEGQDTIRGHPGSSRRGRQGSHYEQSVDRSGHSGSHHSHTT-SQGRSDASRGQ----S 3480
Query: 517 GAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPR 576
G++S R Q R + + G++ S S + + A ++ H G QS G ++
Sbjct: 3481 GSRSASR-QTRNDEQSGDGSRH----SWSHHHEASTQADSSRHSQSGQGQSAGPRTSR-N 3534
Query: 577 QWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRG 636
Q + + ++G + W +A SR+ G A Q G+ + R G
Sbjct: 3535 QGSSVSQDSDSQGHSEDSERWSGSA-----SRNHRGS--AQEQSRDGSRHPTSHHEDRAG 3587
Query: 637 QKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKS 696
+A + + T SGG+ AA S A ++ G+ + + ++
Sbjct: 3588 HGHSAESSRQSGTHHAENSSGGQ--------AASSHEQARSSAGERHGSHHQQSADSSRH 3639
Query: 697 RGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAAS 756
G G A+ + R RG G+++ S G + S G+
Sbjct: 3640 SGIGHGQASSAV----------RDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAGPHQ 3689
Query: 757 KSHGGGGAKRRRGGGAKSRSG---------EKAVTAGGQKAAAAGGKKPPR-VKSRGGRG 806
+SH + R R G RSG E++ +A G+ + GG++ R ++R
Sbjct: 3690 QSH--QESTRGRSAGRSGRSGSFLYQVSTHEQSESAHGRAGPSTGGRQGSRHEQARDSSR 3747
Query: 807 QKAAAGGKKPLR 818
A+ G+ +R
Sbjct: 3748 HSASQEGQDTIR 3759
Score = 89.4 bits (220), Expect = 1e-17
Identities = 158/826 (19%), Positives = 281/826 (34%), Gaps = 88/826 (10%)
Query: 54 SGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGT 113
SG + G+ GQ G+ + +RQ + G+ + G +AA+
Sbjct: 1188 SGHSGSHHSHTTSQGRSDASHGQSGSRSA--SRQTRKDKQSGDGSRHSGSRHHEAASWAD 1245
Query: 114 KSLGGR-------GRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGA-GAQKAAAAAG 165
S + G + R + + S R +GS +R G+ + + G
Sbjct: 1246 SSRHSQVGQEQSSGSRTSRHQGSSVSQDSDSERHSDDSERLSGSASRNHHGSSREQSRDG 1305
Query: 166 VKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKK- 224
+ G + +A+ G + S ++ +S +A+S G+ G R ++
Sbjct: 1306 SRHPGFHQEDRASH-GHSADSSRQSGTHHTESSSHGQAVSSHEQARSSPGERHGSRHQQS 1364
Query: 225 ----------HRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDK-K 273
HR+ A + R G + + + T S G++ K
Sbjct: 1365 ADSSRHSGIGHRQASSAVRDSGHRGSSGSQVTNSEGHSEDSDTQSVSAHGQAGPHQQSHK 1424
Query: 274 LRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKAT 333
+GQ+ +G R ++ G+ S GG R G ++ R + +
Sbjct: 1425 ESARGQSGESSGRSRSFLYQVSSHEQSESTHGQTAPSTGG---RQGSRHEQARNSSRHSA 1481
Query: 334 KAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAK 393
T RG G + G + R G + +S + G R A
Sbjct: 1482 SQDGQDTIRGHPGSSRGGRQGSYHEQSVDRSGHSGYHHSHTTPQGRSDASHGQSGPRSAS 1541
Query: 394 RRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRR 453
R+ R Q ++ G +P R + S+ G+ S G K RR+
Sbjct: 1542 RQ-----------TRNEEQSGDGSRHSGSRHHEPSTRAGSSRHSQVGQGESAGSKTSRRQ 1590
Query: 454 GQKARQKAAEAGAESRGDKKQ---GRQKASAAGTKSRGGGLKSHSGK-NLWRRGQKAEAA 509
G Q G +++ R +A +SR G S + + G AE++
Sbjct: 1591 GSSVSQDRDSEGHSEDSERRSESASRNHYGSAREQSRHGSRNPRSHQEDRASHGHSAESS 1650
Query: 510 GEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGG-----------SKSRQRQKAVAAGATS 558
+ T S G + Q+ A + R G S + +RQ + G +
Sbjct: 1651 RQSGTRHAETSSGGQAASSQEQARSSPGERHGSRHQQSADSSTDSGTGRRQDSSVVGDSG 1710
Query: 559 HGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGG----- 613
+ G Q+ G+ Q+ +A G Q Q++ G + RSG G
Sbjct: 1711 NRGSSGSQASDSEGHSEESDTQSVSAHGQ--AGPHQQSHQESTRGQSGERSGRSGSFLYQ 1768
Query: 614 -------KKAWRQKAAGTGAK--SRKKPWRRGQKDAAAAE-KAWATGATSRGSGGKQPRW 663
+ A + TG + SR + R + +A+ E + G GG+Q
Sbjct: 1769 VSTHEQSESAHGRTGPSTGGRQRSRHEQARDSSRHSASQEGQDTIRGHPGSSRGGRQGSH 1828
Query: 664 QKPAAAGSESSAA------------AAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPW 711
+ + S S + + GQ + R K GDG +++ +
Sbjct: 1829 YEQSVDSSGHSGSHHSHTTSQERSDVSRGQSGSRSVSRQTRNEKQSGDGSRHSGSRHHEA 1888
Query: 712 QRRGKKPR---LGKSRGGGGAKSRGSGGAKSRGS---GGAKSRSGKKAAASKSHGGGGAK 765
R R +G+ + G SR G + S+ S G ++ +AS++H G +
Sbjct: 1889 SSRADSSRHSQVGQGQSSGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHLGSAWE 1948
Query: 766 RRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGRGQKAAA 811
+ R G S + AG +A + + R RGQ A++
Sbjct: 1949 QSRDGSRHPGSHHED-RAGHGHSADSSRQSGTRHTESSSRGQAASS 1993
Score = 86.7 bits (213), Expect = 8e-17
Identities = 148/786 (18%), Positives = 283/786 (36%), Gaps = 75/786 (9%)
Query: 66 AGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRR 125
AG + GQ + K +R+ + +E ++ + + +++ G R+ R
Sbjct: 1568 AGSSRHSQVGQGESAGSKTSRRQGSSVSQDRDSEGHSEDSERRSESASRNHYGSAREQSR 1627
Query: 126 RGQKAAATGSKKPRWR---AQKSAAAGSKNR--GAGAQKAAAAAGVKSQGGEKP----QK 176
G + + + A+ S +G+++ +G Q A++ +S GE+ Q+
Sbjct: 1628 HGSRNPRSHQEDRASHGHSAESSRQSGTRHAETSSGGQAASSQEQARSSPGERHGSRHQQ 1687
Query: 177 AAAAGAKSRSGKKPR--------RRGAKSRGDEDKKGRQREAKSRFGKTRGG---RRKKH 225
+A + S +G++ RG+ D +G E+ ++ G ++ H
Sbjct: 1688 SADSSTDSGTGRRQDSSVVGDSGNRGSSGSQASDSEGHSEESDTQSVSAHGQAGPHQQSH 1747
Query: 226 RRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAG 285
+ G +S R G Q ++A G R G S GG + Q ++++
Sbjct: 1748 QESTRGQSGERSGRSGSFLYQVSTHEQSESAHG---RTGPSTGGRQRSRHEQARDSSRHS 1804
Query: 286 AKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGG 345
A + G T P + RGGR G G T + RG
Sbjct: 1805 ASQEGQDTIRGHPGSS-RGGRQGSHYEQSVDSSGHSGS----HHSHTTSQERSDVSRGQS 1859
Query: 346 GQQKAAVVGVKSRKKQRRRGKK---PRRQKASAAGAKSR----GGGDKKGLREAKRRGDG 398
G + +V +KQ G + R +AS+ SR G G G R ++ +G
Sbjct: 1860 GSR--SVSRQTRNEKQSGDGSRHSGSRHHEASSRADSSRHSQVGQGQSSGPRTSRNQGSS 1917
Query: 399 RKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKAR 458
+ +Q R GS G +SR G G + R +
Sbjct: 1918 VSQDS------DSQGHSEDSERWSGSASRNHLGSAWEQSRDGSRHPGSHHEDRAGHGHSA 1971
Query: 459 QKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGA 518
+ ++G +R + R +A+++ ++R + H + + Q A+++ G
Sbjct: 1972 DSSRQSG--TRHTESSSRGQAASSHEQARSSAGERHGSHH---QLQSADSSRHSGIGHGQ 2026
Query: 519 KSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAG-ATSHGGGGNKQSRGGGGNKPRQ 577
S + + + + A G S+ Q A G A H + +RG G +
Sbjct: 2027 ASSAVRDSGHRGYSGSQASDSEGHSEDSDTQSVSAQGKAGPHQQSHKESARGQSGESSGR 2086
Query: 578 WGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRK------K 631
G T + G + G + D + + R A+ G + + +
Sbjct: 2087 SGSFLYQVSTHEQSESTHGQSAPSTGGRQGSHYDQAQDSSRHSASQEGQDTIRGHPGPSR 2146
Query: 632 PWRRGQKDAAAAEKAWATGA-----TSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEAR 686
R+G + +++ +G+ TS+G R Q + + S + +
Sbjct: 2147 GGRQGSHQEQSVDRSGHSGSHHSHTTSQGRSDAS-RGQSGSRSASRKTYDKEQSGDGSRH 2205
Query: 687 KKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAK 746
A S D +++ VG G+S G ++ RGS ++ S G
Sbjct: 2206 SGSHHHEASSWADSSRHSLVG------------QGQSSGPRTSRPRGSSVSQDSDSEGHS 2253
Query: 747 SRSGKKA-AASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGR 805
S +++ +AS++H G ++ R G RS + G A ++ ++ G
Sbjct: 2254 EDSERRSGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSAESSRQSGTHHAENSSG- 2312
Query: 806 GQKAAA 811
GQ A++
Sbjct: 2313 GQAASS 2318
Score = 85.9 bits (211), Expect = 1e-16
Identities = 180/934 (19%), Positives = 335/934 (35%), Gaps = 164/934 (17%)
Query: 6 HRQCNQAAGRAGPGAPL---GAALARTPVELAAESAAPALSAAAAGVKILGSGDKKLR-- 60
H+Q +Q + R G G+ L + +ES+ + + GV+ GS ++ R
Sbjct: 771 HQQSHQESARDRSGERSRRSGSFLYQVSTHKQSESSH-GWTGPSTGVR-QGSHHEQARDN 828
Query: 61 -RQKAAAGGKKARLRGQKGAVA-GKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGG 118
R A+ G+ +RG G+ G++ H Q +G G +
Sbjct: 829 SRHSASQDGQDT-IRGHPGSSRRGRQGSHHEQSVDRSG----HSGSHHSHTTS------- 876
Query: 119 RGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAA 178
+GR RGQ + + S+ R ++ + GS++ G+ +A++ A + + +
Sbjct: 877 QGRSDASRGQSGSRSASRTTR--NEEQSRDGSRHSGSRHHEASSHADIS-------RHSQ 927
Query: 179 AAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFG------------KTRGGRRKKHR 226
A +S + RR+G+ D D +G +++ G ++R G R
Sbjct: 928 AGQGQSEGSRTSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSAQEQSRHGSRHPRS 987
Query: 227 RPKPAAG---GAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAAL 283
+ AG A S R G + GQ A++ ++R G + ++ ++
Sbjct: 988 HHEDRAGHGHSADSSRQSGTPHAETSSGGQAASSHEQARSSPGERHGSRH-QQSADSSRH 1046
Query: 284 AGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRW------GRGGKKPRRRGQKATKAAA 337
+G RR A++A G G G + G G P ++ + +
Sbjct: 1047 SGIPRRQASSAVRDSGHWGSSGSQASDSEGHSEESDTQSVSGHGQDGPHQQSHQESARDW 1106
Query: 338 AGTKRGGGG---------QQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKG 388
+G + G G +Q + G RR+G + + S+ + S+ G D
Sbjct: 1107 SGGRSGRSGSFIYQVSTHEQSESAHGRTRTSTGRRQGSHHEQARDSSRHSASQEGQDTIR 1166
Query: 389 LREAKRRGDGRKKPRWQN----------------------------PRRRAQKAPAAKPR 420
RRG + Q+ R +++ K
Sbjct: 1167 AHPGSRRGGRQGSHHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRQTRKDKQS 1226
Query: 421 GGGSKKPRRRGPKAAK-------SRGGKSRSGGGKKPRRRGQKARQKAAE---------- 463
G GS+ R +AA S+ G+ +S G + R +G Q +
Sbjct: 1227 GDGSRHSGSRHHEAASWADSSRHSQVGQEQSSGSRTSRHQGSSVSQDSDSERHSDDSERL 1286
Query: 464 AGAESRG----DKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAK 519
+G+ SR ++Q R + G HS + + G + A +
Sbjct: 1287 SGSASRNHHGSSREQSRDGSRHPGFHQEDRASHGHSADSSRQSGTHHTESSSHGQAVSSH 1346
Query: 520 SRGRKQP------RRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGN 573
+ R P R Q+ A + S +G RQ + A + H G Q G+
Sbjct: 1347 EQARSSPGERHGSRHQQSADSSRHSGIG-----HRQASSAVRDSGHRGSSGSQVTNSEGH 1401
Query: 574 KPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSG------------DGGKKAWRQKA 621
Q+ +A G Q +++A G + SG + + Q A
Sbjct: 1402 SEDSDTQSVSAHGQ--AGPHQQSHKESARGQSGESSGRSRSFLYQVSSHEQSESTHGQTA 1459
Query: 622 AGTGAK--SRKKPWRRGQKDAAAAE-KAWATGATSRGSGGKQPRWQKPAAAGSESS---- 674
TG + SR + R + +A+ + + G GG+Q + + + S S
Sbjct: 1460 PSTGGRQGSRHEQARNSSRHSASQDGQDTIRGHPGSSRGGRQGSYHEQSVDRSGHSGYHH 1519
Query: 675 --------AAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPR-----LG 721
+ A+ GQ + R + GDG +++ + R R G
Sbjct: 1520 SHTTPQGRSDASHGQSGPRSASRQTRNEEQSGDGSRHSGSRHHEPSTRAGSSRHSQVGQG 1579
Query: 722 KSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKA-AASKSHGGGGAKRRRGGGAKSRSGEKA 780
+S G ++ +GS ++ R S G S +++ +AS++H G ++ R G RS ++
Sbjct: 1580 ESAGSKTSRRQGSSVSQDRDSEGHSEDSERRSESASRNHYGSAREQSRHGSRNPRSHQED 1639
Query: 781 VTAGGQKAAAAGGKKPPRVKSRGGRGQKAAAGGK 814
+ G A ++ + G R + ++GG+
Sbjct: 1640 RASHGHSAESS--------RQSGTRHAETSSGGQ 1665
Score = 85.9 bits (211), Expect = 1e-16
Identities = 155/777 (19%), Positives = 267/777 (34%), Gaps = 68/777 (8%)
Query: 61 RQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRG 120
R+++ G + + A G A Q +G E+ G+ ++ +S G
Sbjct: 1299 REQSRDGSRHPGFHQEDRASHGHSADSSRQ--SGTHHTESSSHGQAVSSHEQARSSPGE- 1355
Query: 121 RKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAA 180
R R Q A ++ R SA S +RG+ + S+G + +
Sbjct: 1356 RHGSRHQQSADSSRHSGIGHRQASSAVRDSGHRGSSGSQVT-----NSEGHSEDSDTQSV 1410
Query: 181 GAKSRSGKKPRRRGAKSRGDE-DKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRR 239
A ++G + +RG + GR R + H + P+ GG + R
Sbjct: 1411 SAHGQAGPHQQSHKESARGQSGESSGRSRSFLYQVSSHEQSE-STHGQTAPSTGGRQGSR 1469
Query: 240 GGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQG-QNAALAGAKRRGAATAGEKP 298
+ + Q + G SRGG Q + +G G
Sbjct: 1470 HEQARNSSRHSASQDGQDTIRGHPGSSRGGRQGSYHEQSVDRSGHSGYHHSHTTPQGRSD 1529
Query: 299 AAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQK----ATKAAAAGTKRGGGGQQKAAVVG 354
A+ G+ G P+S Q + G R G + +T+A ++ + G G+ G
Sbjct: 1530 ASHGQSG--PRSASRQTRNEEQSGDGSRHSGSRHHEPSTRAGSSRHSQVGQGES----AG 1583
Query: 355 VKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKG----LREAKRRGDGRKKPRWQNPRRR 410
K+ ++Q + R + + ++ R + RE R G + PR R
Sbjct: 1584 SKTSRRQGSSVSQDRDSEGHSEDSERRSESASRNHYGSAREQSRHGS--RNPRSHQEDRA 1641
Query: 411 AQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRG 470
+ A R G++ A S ++RS G++ R Q++A++ +S
Sbjct: 1642 SHGHSAESSRQSGTRHAETSSGGQAASSQEQARSSPGERHGSR----HQQSADSSTDSGT 1697
Query: 471 DKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQK 530
++Q +G + G S S G E+ + +A G ++ +
Sbjct: 1698 GRRQDSSVVGDSGNRGSSGSQASDS------EGHSEESDTQSVSAHGQAGPHQQSHQEST 1751
Query: 531 PAVAGAKSRVGGS----KSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAK 586
+G +S GS S Q A G T GG ++SR + +
Sbjct: 1752 RGQSGERSGRSGSFLYQVSTHEQSESAHGRTGPSTGGRQRSRHEQARDSSRHSASQEGQD 1811
Query: 587 TRGG--GDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAE 644
T G G + G Q + + SG G + SR + R E
Sbjct: 1812 TIRGHPGSSRGGRQGSHYEQSVDSSGHSGSHHSHTTSQERSDVSRGQSGSRSVSRQTRNE 1871
Query: 645 KAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAK--SRGDGGQ 702
K +G SR SG + A++ ++SS + VGQ + + R + S+ Q
Sbjct: 1872 K--QSGDGSRHSGSR----HHEASSRADSSRHSQVGQGQSSGPRTSRNQGSSVSQDSDSQ 1925
Query: 703 NAAVGINPWQRRGKKPRLG----KSRGGG--------GAKSRGSGGAKSRGSGGAKSRSG 750
+ W + LG +SR G G SR SG + S
Sbjct: 1926 GHSEDSERWSGSASRNHLGSAWEQSRDGSRHPGSHHEDRAGHGHSADSSRQSGTRHTESS 1985
Query: 751 KKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAG-GKKPPRVKSRGGRG 806
+ A+ SH + R G + S + +A + + G G+ V+ G RG
Sbjct: 1986 SRGQAASSH----EQARSSAGERHGSHHQLQSADSSRHSGIGHGQASSAVRDSGHRG 2038
Score = 79.0 bits (193), Expect = 2e-14
Identities = 146/776 (18%), Positives = 282/776 (36%), Gaps = 107/776 (13%)
Query: 61 RQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRG 120
++++ G + R + A G A Q +G AEN GG+ AA++ ++ G
Sbjct: 2272 QEQSRDGSRHPRSHHEDRAGHGHSAESSRQ--SGTHHAENSSGGQ--AASSHEQARSSAG 2327
Query: 121 RKPRRRGQKAAATGSKKPRWRAQKSAAA-GSKNRGAGAQKAAAAAGVKSQGGEKPQKAAA 179
+ Q++A + Q S+A S +RG+ +A+ + G + A
Sbjct: 2328 ERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHG 2387
Query: 180 AGAKSRSGKKPRRRGAKSRGDEDKKG----------RQREAKSRFGKTRGGRRKKHRRPK 229
+ + RG +S G + G + A R G + GGR+ H
Sbjct: 2388 QAGPHQQSHQESTRG-RSAGRSGRSGSFLYQVSTHEQSESAHGRTGTSTGGRQGSHH--- 2443
Query: 230 PAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRR 289
K R + Q + G S G+ ++ + R G + G+
Sbjct: 2444 ------KQARDSSRHSTSQEGQDTIHGHPGSSSGGRQGSHYEQLVDRSGHS----GSHHS 2493
Query: 290 GAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPR--RRGQKATKAAAAGTKRGGGGQ 347
+ G A+ G G S +N G + R + +++A ++G + G GQ
Sbjct: 2494 HTTSQGRSDASHGHSGSRSASRQTRNDEQSGDGSRHSGSRHHEASSRADSSGHSQVGQGQ 2553
Query: 348 QKAAVV----GVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPR 403
+ G + +G ++ S + +++ G ++ LR DG + PR
Sbjct: 2554 SEGPRTSRNWGSSFSQDSDSQGHSEDSERWSGSASRNHHGSAQEQLR------DGSRHPR 2607
Query: 404 WQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAE 463
R A R G++ + A S ++RS G++ Q++ +
Sbjct: 2608 SHQEDRAGHGHSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGERHGSHHQQSADSSRH 2667
Query: 464 AGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGR 523
+G G +AS+A R G + +SG +E + ++ +A ++ G
Sbjct: 2668 SGI--------GHGQASSA---VRDSGHRGYSGSQASDNEGHSEDSDTQSVSAHGQA-GS 2715
Query: 524 KQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAA 583
Q Q+ A + G S S Q + + S G +RG G++ Q ++
Sbjct: 2716 HQQSHQESARGRSGETSGHSGSFLYQVSTHEQSESSHGWTGPSTRGRQGSRHEQAQDSSR 2775
Query: 584 AAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQK----AAGTGAKSRKKPWRRGQKD 639
+ ++ G D G S GG++ + + ++G +G+ D
Sbjct: 2776 HSASQDGQDTIRG---------HPGSSRGGRQGYHHEHSVDSSGHSGSHHSHTTSQGRSD 2826
Query: 640 AAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGD 699
A+ G + S + R ++ + GS S + R A + D
Sbjct: 2827 ASR-------GQSGSRSASRTTRNEEQSGDGSRHSGS-------------RHHEASTHAD 2866
Query: 700 GGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGK-KAAASKS 758
+++ + G+S G ++ +GS ++ S G S + +AS++
Sbjct: 2867 ISRHS------------QAVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRN 2914
Query: 759 HGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGRGQKAAAGGK 814
H G ++ R G RS ++ G A ++ + G R + ++GG+
Sbjct: 2915 HHGSAQEQLRDGSRHPRSHQEDRAGHGHSADSS--------RQSGTRHTQTSSGGQ 2962
Score = 76.6 bits (187), Expect = 8e-14
Identities = 163/835 (19%), Positives = 286/835 (34%), Gaps = 130/835 (15%)
Query: 60 RRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAA--------A 111
R + ++GG+ A Q + AG+ H Q++A + G G+ +A +
Sbjct: 2629 RHTQTSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGYS 2688
Query: 112 GTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAG------AQKAAAAAG 165
G+++ G Q +A G ++ + +A G +G Q +
Sbjct: 2689 GSQASDNEGHSEDSDTQSVSAHGQAGSHQQSHQESARGRSGETSGHSGSFLYQVSTHEQS 2748
Query: 166 VKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKH 225
S G P G++ + R A G + +G G +RGGR+ H
Sbjct: 2749 ESSHGWTGPSTRGRQGSRHEQAQDSSRHSASQDGQDTIRGHP-------GSSRGGRQGYH 2801
Query: 226 RRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAG 285
+ G G +G+ A+ G+S G + R +N +G
Sbjct: 2802 HEHSVDSSG-----HSGSHHSHTTSQGRSDASRGQS--------GSRSASRTTRNEEQSG 2848
Query: 286 AKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGG 345
R + + + + R +++ GQ+ G ++ RR+G ++ + G
Sbjct: 2849 DGSRHSGSRHHEASTHADISRHSQAVQGQS----EGSRRSRRQGSSVSQ----DSDSEGH 2900
Query: 346 GQQKAAVVGVKSR------KKQRRRGKK-PRRQKASAAG-AKSRGGGDKKGLREAKRRGD 397
+ G SR ++Q R G + PR + AG S + G R +
Sbjct: 2901 SEDSERWSGSASRNHHGSAQEQLRDGSRHPRSHQEDRAGHGHSADSSRQSGTRHTQTSSG 2960
Query: 398 GRKKPRWQNPRRRA---------QKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGK 448
G+ + R A Q A +++ G G + A + G + S G +
Sbjct: 2961 GQAASSHEQARSSAGERHGSHHQQSADSSRHSGIG----HGQASSAVRDSGHRGYS-GSQ 3015
Query: 449 KPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEA 508
G A + Q + SA G R G HSG L++ ++
Sbjct: 3016 ASDNEGHSEDSDTQSVSAHGQAGSHQQSHQESARG---RSGETSGHSGSFLYQVSTHEQS 3072
Query: 509 AGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSR 568
G +RGR+ R ++ A+ S S+ Q + S GG
Sbjct: 3073 ESSHGW-TGPSTRGRQGSRHEQ-----AQDSSRHSASQYGQDTIRGHPGSSRGGRQGYHH 3126
Query: 569 GGGGNKPRQWGQTAAAAKTRGGGDKQPG--WQKAAAGVTKS--RSGDGGK-KAWRQKAAG 623
+ G + ++G D G ++A+ T++ +SGD + R A
Sbjct: 3127 EHSVDSSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDSSRHSVSRHHEAS 3186
Query: 624 TGAK-SRKKPWRRGQKDAAAAEKAWATGAT----SRGSGGKQPRWQKPAAAGSESSA--- 675
T A SR +GQ + + + + + S G RW A+ S
Sbjct: 3187 THADISRHSQAVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSVQEQ 3246
Query: 676 --------------AAAVGQEAEARKKPRRRRAKSRGDGGQNAA----VGINPWQRRGKK 717
A G A+ ++ R A++ GGQ A+ +P +R G +
Sbjct: 3247 SRHGSRHPRSHHEDRAGHGHSADRSRQSGTRHAET-SSGGQAASSHEQARSSPGERHGSR 3305
Query: 718 -------------PRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGG- 763
PR S ++ GS G+++ S G S ++ + HG G
Sbjct: 3306 HQQSADSSRHSGIPRGQASSAVRDSRHWGSSGSQASDSEGHSEESDTQSVS--GHGQAGP 3363
Query: 764 -------AKRRRGGGAKSRSGE--KAVTAGGQKAAAAGGKKPPRVKSRGGRGQKA 809
+ R R GG RSG V+ Q +A G + + +G ++A
Sbjct: 3364 HQQSHQESARDRSGGRSGRSGSFLYQVSTHEQSESAHGRTRTSTGRRQGSHHEQA 3418
Score = 70.9 bits (172), Expect = 5e-12
Identities = 146/799 (18%), Positives = 263/799 (32%), Gaps = 97/799 (12%)
Query: 54 SGDKKLRRQKAAAGGKKARLRGQKGA-VAGKEARQHWQKAAGAGGAENRGGGEQKAAAAG 112
SG + G+ RGQ G+ A + R Q + + +R A
Sbjct: 3133 SGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDSSRHSVSRHHEASTHADIS 3192
Query: 113 TKSLGGRG-----RKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVK 167
S +G R+ RR+G + + + + + G+ + + G +
Sbjct: 3193 RHSQAVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSVQEQSRHGSR 3252
Query: 168 SQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRR 227
+A + RS + R S G + + +A+S G+ G R ++
Sbjct: 3253 HPRSHHEDRAGHGHSADRSRQSGTRHAETSSGGQAASSHE-QARSSPGERHGSRHQQSAD 3311
Query: 228 -------PKPAAGGA--KSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQG 278
P+ A A SR G Q G + +S G + G ++ ++
Sbjct: 3312 SSRHSGIPRGQASSAVRDSRHWGSSGSQASDSEGHSEESDTQSVSGHGQAGPHQQSHQES 3371
Query: 279 QNAALAGAKRRGAA---TAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKA 335
G R + ++ GR S G R G ++ R + +
Sbjct: 3372 ARDRSGGRSGRSGSFLYQVSTHEQSESAHGRTRTSTGR---RQGSHHEQARDSSRHSASQ 3428
Query: 336 AAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRR 395
T RG G + G + R G + + +S + G R A R+
Sbjct: 3429 EGQDTIRGHPGSSRRGRQGSHYEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRQ 3488
Query: 396 -------GDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGK 448
GDG + W + + +A +++ S+ G+ +S G +
Sbjct: 3489 TRNDEQSGDGSRHS-WSHHHEASTQADSSR-----------------HSQSGQGQSAGPR 3530
Query: 449 KPRRRGQKARQKAAEAGAESRGDKKQG---RQKASAAGTKSRGGGLKSHSG-KNLWRRGQ 504
R +G Q + G ++ G R +A +SR G S ++ G
Sbjct: 3531 TSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHRGSAQEQSRDGSRHPTSHHEDRAGHGH 3590
Query: 505 KAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGG----SKSRQRQKAVAAGATS-- 558
AE++ + T S G + + A + A R G S R + G S
Sbjct: 3591 SAESSRQSGTHHAENSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSA 3650
Query: 559 -----HGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGG 613
H G Q+ G+ Q+ +A G Q Q++ G + RSG G
Sbjct: 3651 VRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQ--AGPHQQSHQESTRGRSAGRSGRSG 3708
Query: 614 KKAWR-----QKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGA-----TSRGS-----GG 658
++ Q + G R+G + A + + + + T RG GG
Sbjct: 3709 SFLYQVSTHEQSESAHGRAGPSTGGRQGSRHEQARDSSRHSASQEGQDTIRGHPGSRRGG 3768
Query: 659 KQPRWQKPAAAGSESSAA------------AAVGQEAEARKKPRRRRAKSRGDGGQNAAV 706
+Q + + + S S + A+ GQ R + GDG +++
Sbjct: 3769 RQGSYHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRETRNEEQSGDGSRHSGS 3828
Query: 707 GINPWQRRGKKPR---LGKSRGGGGAKSRGSGGAKSRGSGG---AKSRSGKKAAASKSHG 760
+ + R G+ G +SR G + S+ S + + +AS++H
Sbjct: 3829 RHHEASTQADSSRHSQSGQGESAGSRRSRRQGSSVSQDSDSEAYPEDSERRSESASRNHH 3888
Query: 761 GGGAKRRRGGGAKSRSGEK 779
G ++ R G S +
Sbjct: 3889 GSSREQSRDGSRHPGSSHR 3907
Score = 65.5 bits (158), Expect = 2e-10
Identities = 120/659 (18%), Positives = 237/659 (35%), Gaps = 92/659 (13%)
Query: 186 SGKKPRRRG-----AKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRG 240
SG K R+ ++ +E+K+ R+R + R G + + + P+ G +
Sbjct: 97 SGHKHRKHSHHDKHEDNKQEENKENRKRPSSLERRNNRKGNKGRSKSPRETGG-----KR 151
Query: 241 GGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAA 300
+K+ R+G + T + GK+ KK + + +N L ++R + EK
Sbjct: 152 HESSSEKKERKGY-SPTHREEEYGKNHHNSSKKEKNKTENTRLGDNRKRLSERLEEKEDN 210
Query: 301 KGRGGRGPKSLGGQNPRWGRGG----------------------KKPRRRGQKATKAAAA 338
+ G ++ G +W + G K R + + +++
Sbjct: 211 E-EGVYDYENTGRMTQKWIQSGHIATYYTIQDEAYDTTDSLLEENKIYERSRSSDGKSSS 269
Query: 339 GTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAA----GAKSRGGGDKKGLREA-K 393
R + + V ++ + ++RRG + + + S + G + A +
Sbjct: 270 QVNR--SRHENTSQVPLQESRTRKRRGSRVSQDRDSEGHSEDSERHSGSASRNHHGSAWE 327
Query: 394 RRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRR 453
+ DG + PR + R + A R G+ R +++ + S P R
Sbjct: 328 QSRDGSRHPRSHDEDRASHGHSADSSRQSGT----RHAETSSRGQTASSHEQARSSPGER 383
Query: 454 GQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKA 513
Q++A++ S + Q S G + G S S + +
Sbjct: 384 HGSGHQQSADSSRHSATGRGQASSAVSDRGHRGSSGSQASDS--------EGHSENSDTQ 435
Query: 514 TAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGN 573
+ +G G +Q Q+ + R G S S Q + S G + G G+
Sbjct: 436 SVSGHGKAGLRQQSHQESTRGRSGERSGRSGSSLYQVSTHEQPDSAHGRTGTSTGGRQGS 495
Query: 574 KPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPW 633
Q ++ + ++ G D G ++ G R G +++ + +G
Sbjct: 496 HHEQARDSSRHSASQEGQDTIRGHPGSSRG---GRQGSHHEQSVNR--SGHSGSHHSHTT 550
Query: 634 RRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRR 693
+G+ DA + G + S +Q R ++ + G+ S + R
Sbjct: 551 SQGRSDA-------SHGQSGSRSASRQTRNEEQSGDGTRHSGS-------------RHHE 590
Query: 694 AKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGK-K 752
A S+ D +++ VG G+S G ++++GS ++ S G S +
Sbjct: 591 ASSQADSSRHSQVG------------QGQSSGPRTSRNQGSSVSQDSDSQGHSEDSERWS 638
Query: 753 AAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGRGQKAAA 811
+AS++H G ++ R G RS + AG +A + K R GQ A++
Sbjct: 639 GSASRNHHGSAQEQSRDGSRHPRSHHED-RAGHGHSADSSRKSGTRHTQNSSSGQAASS 696
Score = 57.0 bits (136), Expect = 7e-08
Identities = 99/527 (18%), Positives = 185/527 (35%), Gaps = 78/527 (14%)
Query: 43 SAAAAGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAG--AGGAEN 100
S A+ G S ++ R + + G + A ++ +H Q G AG +
Sbjct: 3473 SDASRGQSGSRSASRQTRNDEQSGDGSRHSWSHHHEASTQADSSRHSQSGQGQSAGPRTS 3532
Query: 101 RGGGEQKAAAAGTKS--------LGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAG--- 149
R G + + ++ G R R Q+ + GS+ P + A G
Sbjct: 3533 RNQGSSVSQDSDSQGHSEDSERWSGSASRNHRGSAQEQSRDGSRHPTSHHEDRAGHGHSA 3592
Query: 150 --SKNRG-------AGAQKAAAAAGVKSQGGEKP----QKAAAA--------GAKSRSGK 188
S+ G +G Q A++ +S GE+ Q++A + G S + +
Sbjct: 3593 ESSRQSGTHHAENSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVR 3652
Query: 189 KPRRRGAKSRGDEDKKGRQREAKSRFGKTRGG---RRKKHRRPKPAAGGAKSRRGGGKKP 245
RG+ D +G ++ ++ G ++ H+ +S R G
Sbjct: 3653 DSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQESTRGRSAGRSGRSGSFLY 3712
Query: 246 QKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGG 305
Q ++A G R G S GG Q ++++ A + G T P ++ RGG
Sbjct: 3713 QVSTHEQSESAHG---RAGPSTGGRQGSRHEQARDSSRHSASQEGQDTIRGHPGSR-RGG 3768
Query: 306 R--------------------GPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGG 345
R S G + G+ G + R + + + G++ G
Sbjct: 3769 RQGSYHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRETRNEEQSGDGSRHSGS 3828
Query: 346 GQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLRE-AKRRGDGRKKPRW 404
+A+ SR Q +G+ +++ G+ D + E ++RR + +
Sbjct: 3829 RHHEASTQADSSRHSQSGQGESAGSRRSRRQGSSVSQDSDSEAYPEDSERRSESASRNHH 3888
Query: 405 QNPRRRAQKAPAAKPRGGGSKKP---RRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKA 461
+ R +++ GS+ P R +S +S S K+ ++ A
Sbjct: 3889 GSSREQSR---------DGSRHPGSSHRDTASHVQSSPVQSDSSTAKEHGHFSSLSQDSA 3939
Query: 462 AEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEA 508
+G +SRG +S+ +S G + +WR G A
Sbjct: 3940 YHSGIQSRGSP----HSSSSYHYQSEGTERQKGQSGLVWRHGSYGSA 3982
Score = 50.4 bits (119), Expect = 6e-06
Identities = 118/691 (17%), Positives = 242/691 (35%), Gaps = 112/691 (16%)
Query: 60 RRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAA--------AA 111
R + ++GG+ A Q + G+ Q++A + G+ +A ++
Sbjct: 3277 RHAETSSGGQAASSHEQARSSPGERHGSRHQQSADSSRHSGIPRGQASSAVRDSRHWGSS 3336
Query: 112 GTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAA---AGSKNRGAGA---QKAAAAAG 165
G+++ G Q + G P ++ + +A +G ++ +G+ Q +
Sbjct: 3337 GSQASDSEGHSEESDTQSVSGHGQAGPHQQSHQESARDRSGGRSGRSGSFLYQVSTHEQS 3396
Query: 166 VKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKT-------- 217
+ G + G+ + R A G + +G SR G+
Sbjct: 3397 ESAHGRTRTSTGRRQGSHHEQARDSSRHSASQEGQDTIRGHP--GSSRRGRQGSHYEQSV 3454
Query: 218 -RGGRRKKHRRPKPAAGGAKSRRG--GGKKPQKQRRRGQKAATGGK-------------- 260
R G H + G + + RG G + +Q R +++ G +
Sbjct: 3455 DRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRQTRNDEQSGDGSRHSWSHHHEASTQAD 3514
Query: 261 ----SRVGKSRGGGDKKLRRQGQNAALAGAKR---------RGAATAGEKPAAKGR---G 304
S+ G+ + G + R QG + + + G+A+ + +A+ + G
Sbjct: 3515 SSRHSQSGQGQSAGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHRGSAQEQSRDG 3574
Query: 305 GRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRR 364
R P S G + R+ G + ++ G + +Q + G + ++
Sbjct: 3575 SRHPTSHHEDRAGHGHSAESSRQSGTHHAENSSGG-QAASSHEQARSSAGERHGSHHQQS 3633
Query: 365 GKKPRRQ-----KASAA-------GAKSRGGGDKKGLREAKRR----GDGRKKPRWQNPR 408
R +AS+A G+ D +G E G+ P Q+ +
Sbjct: 3634 ADSSRHSGIGHGQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQ 3693
Query: 409 RRAQKAPAAKPRGGGS--------KKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQK 460
+ A + GS ++ +A S GG+ G + + +R
Sbjct: 3694 ESTRGRSAGRSGRSGSFLYQVSTHEQSESAHGRAGPSTGGRQ----GSRHEQARDSSRHS 3749
Query: 461 AAEAGAES----RGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAA 516
A++ G ++ G ++ GRQ + + R G SH + A + +A
Sbjct: 3750 ASQEGQDTIRGHPGSRRGGRQGSYHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSRSA 3809
Query: 517 GAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPR 576
++R +Q +G SR G SR + + A ++ H G +S G ++ R
Sbjct: 3810 SRETRNEEQ--------SGDGSRHSG--SRHHEASTQADSSRHSQSGQGESAGSRRSR-R 3858
Query: 577 QWGQTAAAAKTRGGGDKQPGWQKAAA----GVTKSRSGDGGK---KAWRQKAAGTGA--- 626
Q + + + + ++A+ G ++ +S DG + + R A+ +
Sbjct: 3859 QGSSVSQDSDSEAYPEDSERRSESASRNHHGSSREQSRDGSRHPGSSHRDTASHVQSSPV 3918
Query: 627 -KSRKKPWRRGQKDAAAAEKAWATGATSRGS 656
G + + + A+ +G SRGS
Sbjct: 3919 QSDSSTAKEHGHFSSLSQDSAYHSGIQSRGS 3949
>gi|158854042 hypothetical protein LOC222183 [Homo sapiens]
Length = 653
Score = 91.7 bits (226), Expect = 3e-18
Identities = 117/570 (20%), Positives = 214/570 (37%), Gaps = 97/570 (17%)
Query: 220 GRRKKH---RRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRR 276
G R KH P K ++GG ++ +K+RR + + G S + K + K +++
Sbjct: 153 GYRTKHWSSSSASPPPKKKKKKKGGHRRSRKKRRLESECSCGSSSPLRKKK----KSVKK 208
Query: 277 QGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAA 336
++ + +G++R+ + + + K ++P G++ R ++ +
Sbjct: 209 HRRDRSDSGSRRKRRHRSRSSKCKRKEKNKEKKRPHTESP-----GRRSHRHSSGSSHSP 263
Query: 337 AAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRG 396
+ + + K R G+K Q++S + + S GG G + + G
Sbjct: 264 SLSSHYSDSRSPS------RLSPKHRDEGRKTGSQRSSGSRSPSPSGGSGWGSPQ-RNGG 316
Query: 397 DGRK----------------KPRWQNPRRRAQKAPAAK-PRGGGSKKPRRRGPKAAKSRG 439
G++ KP +PR R + A AA P G + P R +++ RG
Sbjct: 317 SGQRSGAHGGRPGSAHSPPDKPSSPSPRVRDKAAAAAPTPPARGKESPSPRSAPSSQGRG 376
Query: 440 GKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNL 499
G++ G G++ RRR ++ R +++ + RG ++ + S SG
Sbjct: 377 GRAAGGAGRRRRRRRRRRRSRSSASAPRRRGRRRPRPAPPRGSSRSLSRARSSSDSGSGR 436
Query: 500 WRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSH 559
G E E+ K R +++P R +PA G +
Sbjct: 437 GAPGPGPEPGSERGHGGHGK-RAKERPPRARPASTSPSPGAHGRR--------------- 480
Query: 560 GGGGNKQSRGGGGNKPRQWGQTAAAAKTRG-GGDKQPGWQKAAAGVTK--SRSGDGGKKA 616
GG K S G PR W + + +K+R +K+P + K SR DG +A
Sbjct: 481 GGPEGKSSSRSPGPHPRSWSSSRSPSKSRSRSAEKRPHSPSRSPSPKKPLSRDKDGEGRA 540
Query: 617 WRQKAAGTGAKSRKK---PWRRGQKDAAA-AEKAWATGATSRGSGGKQPRWQKPAAAGSE 672
+A T A+ R + P R+ ++D+ + E T A R +P S
Sbjct: 541 RHSEAEATRARRRSRSYSPIRKRRRDSPSFMEPRRITSARKRPIPYYRP---------SP 591
Query: 673 SSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSR 732
SS+++ + + R R P G S G ++S
Sbjct: 592 SSSSSCLSSDYSTRSHSR--------------------------SPSPGHSHGSYSSRSH 625
Query: 733 GSGGAKSRGSGGAKSRSGKKAAASKSHGGG 762
G+ +SR +++ S + S S GG
Sbjct: 626 GT---RSRTRSPSRTPSPSYHSRSSSESGG 652
Score = 68.9 bits (167), Expect = 2e-11
Identities = 108/500 (21%), Positives = 184/500 (36%), Gaps = 88/500 (17%)
Query: 119 RGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAA 178
RG + R ++++ S P+ + +K G R ++ + S G P +
Sbjct: 149 RGHRGYRTKHWSSSSASPPPKKKKKKK---GGHRRSRKKRRLESEC---SCGSSSPLRK- 201
Query: 179 AAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSR 238
K +S KK RR + S ++ R R +K + R + K+ +RP + G +S
Sbjct: 202 ----KKKSVKKHRRDRSDSGSRRKRRHRSRSSKCK----RKEKNKEKKRPHTESPGRRSH 253
Query: 239 R---GGGKKPQ----------------KQRRRGQKAA---TGGKSRVGKSRGGGDKKLRR 276
R G P K R G+K + G S G G +R
Sbjct: 254 RHSSGSSHSPSLSSHYSDSRSPSRLSPKHRDEGRKTGSQRSSGSRSPSPSGGSGWGSPQR 313
Query: 277 QGQNAALAGAK---------------------RRGAATAGEKPAAKGRGGRGPKSLGGQN 315
G + +GA R AA A P A+G+ P+S
Sbjct: 314 NGGSGQRSGAHGGRPGSAHSPPDKPSSPSPRVRDKAAAAAPTPPARGKESPSPRSAPSSQ 373
Query: 316 PRWGR-----GGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRR 370
R GR G ++ RRR ++ ++++A+ +R G + + A SR R R
Sbjct: 374 GRGGRAAGGAGRRRRRRRRRRRSRSSASAPRRRGRRRPRPAPPRGSSRSLSRARSSSD-- 431
Query: 371 QKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRR 430
S +G + G G + G RG G R + RA+ A + G ++
Sbjct: 432 ---SGSGRGAPGPGPEPG----SERGHGGHGKRAKERPPRARPASTSPSPGAHGRRGGPE 484
Query: 431 GPKAAKSRGGKSRS-GGGKKPRRRGQKARQKAAEAGAESRGDKK--------QGRQKASA 481
G +++S G RS + P + ++ +K + + S KK +GR + S
Sbjct: 485 GKSSSRSPGPHPRSWSSSRSPSKSRSRSAEKRPHSPSRSPSPKKPLSRDKDGEGRARHSE 544
Query: 482 AGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQP-RRQKPAVAGAKSRV 540
A +S+S RR + + T+A RK+P +P+ + + S +
Sbjct: 545 AEATRARRRSRSYSPIRKRRRDSPSFMEPRRITSA------RKRPIPYYRPSPSSSSSCL 598
Query: 541 GGSKSRQRQKAVAAGATSHG 560
S + + SHG
Sbjct: 599 SSDYSTRSHSRSPSPGHSHG 618
Score = 65.5 bits (158), Expect = 2e-10
Identities = 91/404 (22%), Positives = 146/404 (36%), Gaps = 68/404 (16%)
Query: 441 KSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLW 500
K + GG RR +K R+ +E S G R+K + R +S SG
Sbjct: 172 KKKKGG----HRRSRKKRRLESEC---SCGSSSPLRKKKKSVKKHRRD---RSDSGSRRK 221
Query: 501 RRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHG 560
RR + + ++ K++ +K+P + P + G S S +SH
Sbjct: 222 RRHRSRSSKCKRKE----KNKEKKRPHTESPGRRSHRHSSGSSHS--------PSLSSHY 269
Query: 561 GGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQK 620
SR P+ + R G + P + + R+G G+++
Sbjct: 270 SDSRSPSR----LSPKHRDEGRKTGSQRSSGSRSPSPSGGSGWGSPQRNGGSGQRSGAH- 324
Query: 621 AAGTGAKSRKKPWRRGQKDAAAAEKAWATGAT--SRGSGGKQPRWQKPAAAGSESSAAAA 678
G + P + +KA A T +RG PR P++ G AA
Sbjct: 325 -GGRPGSAHSPPDKPSSPSPRVRDKAAAAAPTPPARGKESPSPR-SAPSSQGRGGRAAGG 382
Query: 679 VGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAK 738
G+ R++ RRRR +SR P +R ++PR RG + SR +
Sbjct: 383 AGR----RRRRRRRRRRSRSSASA-------PRRRGRRRPRPAPPRGSSRSLSRARSSSD 431
Query: 739 SRGSGGAKSRSGKKAAASKSHGGGG--AKRR-----------------RGGGAKSRSGEK 779
S GSG G + + + HGG G AK R R GG + +S +
Sbjct: 432 S-GSGRGAPGPGPEPGSERGHGGHGKRAKERPPRARPASTSPSPGAHGRRGGPEGKSSSR 490
Query: 780 AVTAGGQKAAAAGGKKPPRVKSRGG----RGQKAAAGGKKPLRR 819
+ G + + + P + +SR + KKPL R
Sbjct: 491 --SPGPHPRSWSSSRSPSKSRSRSAEKRPHSPSRSPSPKKPLSR 532
Score = 62.4 bits (150), Expect = 2e-09
Identities = 111/510 (21%), Positives = 188/510 (36%), Gaps = 89/510 (17%)
Query: 57 KKLRRQKAAAGGKKARLRGQKGAVA-----GKEARQHWQKAAGAGGAENRGGGEQKAAAA 111
KK RR ++ +G ++ R + + KE ++ ++ G + G + +
Sbjct: 207 KKHRRDRSDSGSRRKRRHRSRSSKCKRKEKNKEKKRPHTESPGRRSHRHSSGSSHSPSLS 266
Query: 112 G----TKSLGGRGRKPRRRGQKAAA---TGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAA 164
++S K R G+K + +GS+ P + +N G+G Q++ A
Sbjct: 267 SHYSDSRSPSRLSPKHRDEGRKTGSQRSSGSRSPSPSGGSGWGSPQRNGGSG-QRSGAHG 325
Query: 165 GVKSQGGEKPQKAAAAGAKSR-----SGKKPRRRGAKS---RGDEDKKGRQREAKSRFGK 216
G P K ++ + R + P RG +S R +GR A G+
Sbjct: 326 GRPGSAHSPPDKPSSPSPRVRDKAAAAAPTPPARGKESPSPRSAPSSQGRGGRAAGGAGR 385
Query: 217 TRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSR-VGKSRGGGDKKLR 275
R RR+ RR ++ A RRG RRR + A G SR + ++R D
Sbjct: 386 RRRRRRR--RRRSRSSASAPRRRG--------RRRPRPAPPRGSSRSLSRARSSSD---- 431
Query: 276 RQGQNAALAGAKRRGAATAGEKPAA-KGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATK 334
RGA G +P + +G GG G ++ + PR R +
Sbjct: 432 ---------SGSGRGAPGPGPEPGSERGHGGHGKRA----------KERPPRARPASTSP 472
Query: 335 AAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKR 394
+ A +RG G + + R G PR +S + +KSR R A++
Sbjct: 473 SPGAHGRRG----------GPEGKSSSRSPGPHPRSWSSSRSPSKSRS-------RSAEK 515
Query: 395 RGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRG 454
R R + K P ++ + G + R +A ++R +SRS + RRR
Sbjct: 516 RPHSPS-------RSPSPKKPLSRDK-DGEGRARHSEAEATRAR-RRSRSYSPIRKRRRD 566
Query: 455 QKARQKAAE-AGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKA 513
+ + A R +S++ S +SHS R + G +
Sbjct: 567 SPSFMEPRRITSARKRPIPYYRPSPSSSSSCLSSDYSTRSHS-----RSPSPGHSHGSYS 621
Query: 514 TAA-GAKSRGRKQPRRQKPAVAGAKSRVGG 542
+ + G +SR R R P+ S G
Sbjct: 622 SRSHGTRSRTRSPSRTPSPSYHSRSSSESG 651
Score = 54.7 bits (130), Expect = 3e-07
Identities = 67/316 (21%), Positives = 113/316 (35%), Gaps = 22/316 (6%)
Query: 500 WRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSH 559
W + +K G R RK+ R + G+ S + R+++K+V
Sbjct: 159 WSSSSASPPPKKKKKKKGGHRRSRKKRRLESECSCGSSSPL-----RKKKKSVKKHRRDR 213
Query: 560 GGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQ 619
G+++ R + K + K+P + + SG +
Sbjct: 214 SDSGSRRKRRHRSRSSK------CKRKEKNKEKKRPHTESPGRRSHRHSSGSSHSPSLSS 267
Query: 620 KAAGTGAKSRKKPWRR--GQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAA 677
+ + + SR P R G+K + + + S GSG P Q+ +G S A
Sbjct: 268 HYSDSRSPSRLSPKHRDEGRKTGSQRSSGSRSPSPSGGSGWGSP--QRNGGSGQRSGAHG 325
Query: 678 AVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKK---PRLG-KSRGGGGAKSRG 733
G+ A P + + S + AA P RGK+ PR S+G GG + G
Sbjct: 326 --GRPGSAHSPPDKPSSPSPRVRDKAAAAAPTP-PARGKESPSPRSAPSSQGRGGRAAGG 382
Query: 734 SGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGG 793
+G + R +SRS A + RG + +G + A G
Sbjct: 383 AGRRRRRRRRRRRSRSSASAPRRRGRRRPRPAPPRGSSRSLSRARSSSDSGSGRGAPGPG 442
Query: 794 KKPPRVKSRGGRGQKA 809
+P + GG G++A
Sbjct: 443 PEPGSERGHGGHGKRA 458
>gi|239756562 PREDICTED: hypothetical protein [Homo sapiens]
Length = 235
Score = 89.4 bits (220), Expect = 1e-17
Identities = 68/171 (39%), Positives = 80/171 (46%), Gaps = 34/171 (19%)
Query: 286 AKRRGAATAGEKPAAKGRG--GRGPKSLGGQNPRWGRGGKK--PRRRGQKATKAAAAGTK 341
A+RR A K + GR G+GP S W R + P + +A
Sbjct: 80 AERRSMQAAAAKAGSPGRRRVGKGPPS----RESWTRSAPQRCPSQDAGRAGSRVCRSRP 135
Query: 342 RGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKK 401
+ GGQ KAA G K R GK+PRRQK +AAGAKSRGG K
Sbjct: 136 QSRGGQ-KAAASGAKRRGVG---GKEPRRQKPAAAGAKSRGGKSHK-------------- 177
Query: 402 PRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRR 452
PRRR QKA AK GGG KP++ AK+RGG GGGKKPRR
Sbjct: 178 ----KPRRRGQKAAPAKNSGGGGNKPQKAAAAGAKNRGG----GGGKKPRR 220
Score = 78.6 bits (192), Expect = 2e-14
Identities = 71/191 (37%), Positives = 95/191 (49%), Gaps = 27/191 (14%)
Query: 322 GKKP--RRRGQKATKAAAAG--TKRGGGGQQKAAVVGVKSRKKQRRR-GKKPRRQKASAA 376
G++P RG++ T A A + RG ++ K+ RRR GK P +++
Sbjct: 53 GRRPCASHRGRRITPATALLLLSHRGRAERRSMQAAAAKAGSPGRRRVGKGPPSRESWTR 112
Query: 377 GAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKA-- 434
A R ++A R G + R Q+ + A AK RG G K+PRR+ P A
Sbjct: 113 SAPQRCPS-----QDAGRAGSRVCRSRPQSRGGQKAAASGAKRRGVGGKEPRRQKPAAAG 167
Query: 435 AKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSH 494
AKSRGGKS KKPRRRGQKA A A++ G QKA+AAG K+RGGG
Sbjct: 168 AKSRGGKSH----KKPRRRGQKA------APAKNSGGGGNKPQKAAAAGAKNRGGG---- 213
Query: 495 SGKNLWRRGQK 505
G RRG++
Sbjct: 214 -GGKKPRRGRR 223
Score = 77.4 bits (189), Expect = 5e-14
Identities = 65/183 (35%), Positives = 85/183 (46%), Gaps = 24/183 (13%)
Query: 408 RRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAE 467
+R A + P A RG RR P A S G+ RR Q A KA G
Sbjct: 49 QRPAGRRPCASHRG------RRITPATALLL----LSHRGRAERRSMQAAAAKAGSPGRR 98
Query: 468 SRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRG--RKQ 525
G R+ + + + +G + R ++ G+KA A+GAK RG K+
Sbjct: 99 RVGKGPPSRESWTRSAPQRCPSQDAGRAGSRVCRSRPQSRG-GQKAAASGAKRRGVGGKE 157
Query: 526 PRRQKPAVAGAKSRVGGSKSRQRQKA-VAAGATSHGGGGNKQSR----------GGGGNK 574
PRRQKPA AGAKSR G S + R++ AA A + GGGGNK + GGGG K
Sbjct: 158 PRRQKPAAAGAKSRGGKSHKKPRRRGQKAAPAKNSGGGGNKPQKAAAAGAKNRGGGGGKK 217
Query: 575 PRQ 577
PR+
Sbjct: 218 PRR 220
Score = 75.5 bits (184), Expect = 2e-13
Identities = 61/180 (33%), Positives = 79/180 (43%), Gaps = 30/180 (16%)
Query: 226 RRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAG 285
RR PA G + + + KA + G+ RVGK + R Q
Sbjct: 63 RRITPATALLLLSHRGRAERRSMQAAAAKAGSPGRRRVGKGPPSRESWTRSAPQRCPSQD 122
Query: 286 AKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGG 345
A R G+ +P ++G G K+ R G GGK+PRR+ K AAAG K GG
Sbjct: 123 AGRAGSRVCRSRPQSRG----GQKAAASGAKRRGVGGKEPRRQ-----KPAAAGAKSRGG 173
Query: 346 GQQKAAVVGVKSRKKQRRRGKKP-----------RRQKASAAGAKSRGGGDKKGLREAKR 394
KS KK RRRG+K + QKA+AAGAK+RGGG K R +R
Sbjct: 174 ----------KSHKKPRRRGQKAAPAKNSGGGGNKPQKAAAAGAKNRGGGGGKKPRRGRR 223
Score = 72.4 bits (176), Expect = 2e-12
Identities = 62/165 (37%), Positives = 86/165 (52%), Gaps = 31/165 (18%)
Query: 100 NRGGGEQKAAAAGTKSLGGRGRKPRRRG--QKAAATGSKKPRWRAQKSAAAGSK-----N 152
+RG E+++ A G GR+ +G + + T S R +Q + AGS+
Sbjct: 76 HRGRAERRSMQAAAAKAGSPGRRRVGKGPPSRESWTRSAPQRCPSQDAGRAGSRVCRSRP 135
Query: 153 RGAGAQKAAAA-AGVKSQGGEKP--QKAAAAGAKSRSGK---KPRRRGAKSRGDEDKKGR 206
+ G QKAAA+ A + GG++P QK AAAGAKSR GK KPRRRG K+ ++ G
Sbjct: 136 QSRGGQKAAASGAKRRGVGGKEPRRQKPAAAGAKSRGGKSHKKPRRRGQKAAPAKNSGG- 194
Query: 207 QREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGG-KKPQKQRR 250
GG + + K AA GAK+R GGG KKP++ RR
Sbjct: 195 ------------GGNKPQ----KAAAAGAKNRGGGGGKKPRRGRR 223
Score = 70.9 bits (172), Expect = 5e-12
Identities = 67/185 (36%), Positives = 84/185 (45%), Gaps = 29/185 (15%)
Query: 150 SKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRS-GKKPRRRGAKSRGDEDKKGRQR 208
+ +RG A A + +G + + AA AK+ S G++ +G SR + QR
Sbjct: 58 ASHRGRRITPATALLLLSHRGRAERRSMQAAAAKAGSPGRRRVGKGPPSRESWTRSAPQR 117
Query: 209 EAKSRFGKTRGGRRKKHRRP------KPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSR 262
G R G R RP K AA GAK R GGK+P++Q+ AA G KSR
Sbjct: 118 CPSQDAG--RAGSRVCRSRPQSRGGQKAAASGAKRRGVGGKEPRRQK----PAAAGAKSR 171
Query: 263 VGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGG 322
GKS KK RR+GQ AA A G +K AA G RG G GG
Sbjct: 172 GGKSH----KKPRRRGQKAAPA-KNSGGGGNKPQKAAAAGAKNRG-----------GGGG 215
Query: 323 KKPRR 327
KKPRR
Sbjct: 216 KKPRR 220
Score = 70.5 bits (171), Expect = 6e-12
Identities = 58/174 (33%), Positives = 76/174 (43%), Gaps = 16/174 (9%)
Query: 104 GEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAA 163
G + A L RGR RR Q AAA R R K + + Q+ +
Sbjct: 62 GRRITPATALLLLSHRGRAERRSMQAAAAKAGSPGRRRVGKGPPSRESWTRSAPQRCPS- 120
Query: 164 AGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGR-R 222
G + + +SR G+K GAK RG K+ R+++ + K+RGG+
Sbjct: 121 ----QDAGRAGSRVCRSRPQSRGGQKAAASGAKRRGVGGKEPRRQKPAAAGAKSRGGKSH 176
Query: 223 KKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRR 276
KK RR A AK+ GGG KPQK AA G K+R GGG KK RR
Sbjct: 177 KKPRRRGQKAAPAKNSGGGGNKPQK------AAAAGAKNR----GGGGGKKPRR 220
Score = 68.9 bits (167), Expect = 2e-11
Identities = 69/228 (30%), Positives = 100/228 (43%), Gaps = 57/228 (25%)
Query: 529 QKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTR 588
Q+PA + + R+ A A SH G ++S AAAAK
Sbjct: 49 QRPA---GRRPCASHRGRRITPATALLLLSHRGRAERRS------------MQAAAAKAG 93
Query: 589 GGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAK-SRKKPWRRGQKDAAAAEKAW 647
G ++ G + +S + ++ Q A G++ R +P RG +KA
Sbjct: 94 SPGRRRVGKGPPSR---ESWTRSAPQRCPSQDAGRAGSRVCRSRPQSRG------GQKAA 144
Query: 648 ATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVG 707
A+GA RG GGK+PR QKPAAAG++S + ++ KKPR
Sbjct: 145 ASGAKRRGVGGKEPRRQKPAAAGAKS-------RGGKSHKKPR----------------- 180
Query: 708 INPWQRRGKKPRLGKSRGGGGAKSR--GSGGAKSRGSGGAKS-RSGKK 752
RRG+K K+ GGGG K + + GAK+RG GG K R G++
Sbjct: 181 -----RRGQKAAPAKNSGGGGNKPQKAAAAGAKNRGGGGGKKPRRGRR 223
Score = 65.9 bits (159), Expect = 1e-10
Identities = 41/86 (47%), Positives = 51/86 (59%), Gaps = 5/86 (5%)
Query: 44 AAAAGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGG 103
AAA+G K G G K+ RRQK AA G K+R G + K+ R+ QKAA A + G
Sbjct: 143 AAASGAKRRGVGGKEPRRQKPAAAGAKSR-----GGKSHKKPRRRGQKAAPAKNSGGGGN 197
Query: 104 GEQKAAAAGTKSLGGRGRKPRRRGQK 129
QKAAAAG K+ GG G K RRG++
Sbjct: 198 KPQKAAAAGAKNRGGGGGKKPRRGRR 223
Score = 64.7 bits (156), Expect = 3e-10
Identities = 67/199 (33%), Positives = 93/199 (46%), Gaps = 37/199 (18%)
Query: 361 QRRRGKKP----RRQKASAAGA----KSRGGGDKKGLREA--KRRGDGRKKPRWQNPRRR 410
QR G++P R ++ + A A RG +++ ++ A K GR++ P R
Sbjct: 49 QRPAGRRPCASHRGRRITPATALLLLSHRGRAERRSMQAAAAKAGSPGRRRVGKGPPSRE 108
Query: 411 AQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRG 470
+ A P+ S+ R G + +SR +S GG+K G K R G
Sbjct: 109 SWTRSA--PQRCPSQDAGRAGSRVCRSR---PQSRGGQKAAASGAKRR---------GVG 154
Query: 471 DKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQK 530
K+ RQK +AAG KSRGG KSH K RRGQK AA AK+ G + QK
Sbjct: 155 GKEPRRQKPAAAGAKSRGG--KSH--KKPRRRGQK---------AAPAKNSGGGGNKPQK 201
Query: 531 PAVAGAKSRVGGSKSRQRQ 549
A AGAK+R GG + R+
Sbjct: 202 AAAAGAKNRGGGGGKKPRR 220
Score = 64.3 bits (155), Expect = 4e-10
Identities = 71/199 (35%), Positives = 82/199 (41%), Gaps = 45/199 (22%)
Query: 506 AEAAGEKATAAGA----KSRGRKQPRRQKPAVAGAKS----RVG-GSKSRQRQKAVAAGA 556
A G + T A A RGR + R + A A A S RVG G SR+ A
Sbjct: 58 ASHRGRRITPATALLLLSHRGRAERRSMQAAAAKAGSPGRRRVGKGPPSRESWTRSAPQR 117
Query: 557 TSHGGGGNKQSRGGGGNKPRQWGQTAAA--AKTRGGGDKQPGWQKAAAGVTKSRSGDGGK 614
G SR + GQ AAA AK RG G K+P QK AA KSR
Sbjct: 118 CPSQDAGRAGSRVCRSRPQSRGGQKAAASGAKRRGVGGKEPRRQKPAAAGAKSR------ 171
Query: 615 KAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESS 674
G KS KKP RRGQK A A + G GG +P QK AAAG+++
Sbjct: 172 ----------GGKSHKKPRRRGQK---------AAPAKNSGGGGNKP--QKAAAAGAKNR 210
Query: 675 AAAAVGQEAEARKKPRRRR 693
KKPRR R
Sbjct: 211 GGG-------GGKKPRRGR 222
Score = 58.5 bits (140), Expect = 2e-08
Identities = 57/201 (28%), Positives = 85/201 (42%), Gaps = 29/201 (14%)
Query: 636 GQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAK 695
G + A AA++ A + G++P + ++A + A ++ + A
Sbjct: 31 GAQPAQAADEVLELPALLQRPAGRRPCASHRGRRITPATALLLLSHRGRAERRSMQAAAA 90
Query: 696 SRGDGGQNAAVGINP-----WQRRGKKPRLGKSRGGGGAK-------SRG-----SGGAK 738
G G+ VG P W R + + G G++ SRG + GAK
Sbjct: 91 KAGSPGRRR-VGKGPPSRESWTRSAPQRCPSQDAGRAGSRVCRSRPQSRGGQKAAASGAK 149
Query: 739 SRGSGGAKSRSGKKAAA-SKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPP 797
RG GG + R K AAA +KS GG K+ R R G+KA A K + GG KP
Sbjct: 150 RRGVGGKEPRRQKPAAAGAKSRGGKSHKKPR------RRGQKAAPA---KNSGGGGNKPQ 200
Query: 798 RVKSRGGRGQKAAAGGKKPLR 818
+ + G + + GGKKP R
Sbjct: 201 KAAAAGAK-NRGGGGGKKPRR 220
Score = 54.7 bits (130), Expect = 3e-07
Identities = 45/177 (25%), Positives = 74/177 (41%), Gaps = 29/177 (16%)
Query: 600 AAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSR----- 654
A A + S G +++ + AA G+ P RR + ++W A R
Sbjct: 68 ATALLLLSHRGRAERRSMQAAAAKAGS-----PGRRRVGKGPPSRESWTRSAPQRCPSQD 122
Query: 655 -GSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQR 713
G G + +P + G + +AA+ + K+PRR++ + G + P +R
Sbjct: 123 AGRAGSRVCRSRPQSRGGQKAAASGAKRRGVGGKEPRRQKPAAAGAKSRGGKSHKKP-RR 181
Query: 714 RGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGG 770
RG+K K+ GGGG K + + AA +K+ GGGG K+ R G
Sbjct: 182 RGQKAAPAKNSGGGGNKPQKAA-----------------AAGAKNRGGGGGKKPRRG 221
Score = 43.1 bits (100), Expect = 0.001
Identities = 56/177 (31%), Positives = 77/177 (43%), Gaps = 32/177 (18%)
Query: 667 AAAGSESSAAAAVGQEAEAR-KKPRRRRAKSRGDGGQ-NAAVGINPWQRRGKKPRLGKSR 724
+A G++ + AA E A ++P RR + G + A + RG+ R +S
Sbjct: 28 SALGAQPAQAADEVLELPALLQRPAGRRPCASHRGRRITPATALLLLSHRGRAER--RSM 85
Query: 725 GGGGAKSRGSGGAKSRGSGGAK----SRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKA 780
AK+ GS G + G G +RS + S+ G G++ R +SR G+KA
Sbjct: 86 QAAAAKA-GSPGRRRVGKGPPSRESWTRSAPQRCPSQDAGRAGSRVCRSR-PQSRGGQKA 143
Query: 781 VTAGGQKAAAAGGKKPPR-------VKSRGG--------RGQKAA------AGGKKP 816
A G K GGK+P R KSRGG RGQKAA GG KP
Sbjct: 144 -AASGAKRRGVGGKEPRRQKPAAAGAKSRGGKSHKKPRRRGQKAAPAKNSGGGGNKP 199
>gi|239754474 PREDICTED: similar to mucin [Homo sapiens]
Length = 417
Score = 88.2 bits (217), Expect = 3e-17
Identities = 120/451 (26%), Positives = 181/451 (40%), Gaps = 81/451 (17%)
Query: 272 KKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQK 331
+KLR + ++ ++P + GG G + G +P + G + R ++
Sbjct: 13 RKLRESSEGDQWLENEKTKPLRPQQQPQCQPAGGTGQRRGSGSSPSADQQGAQDRE--EE 70
Query: 332 ATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLRE 391
A A AA +R +++AA V + R +K + + AG G G ++G R
Sbjct: 71 AAAAPAADQQRAQDREEEAAAAPVPTSSGHRTEKRKRLQLQCQPAG----GTGQRRGSRS 126
Query: 392 AKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPR 451
+ R + R A AP RG ++K +R+ P+ + G R G G P
Sbjct: 127 SPSADQQRAQDR----EEEAAAAPVPTSRGHRTEKRKRQQPQRRPAGGTGQRRGSGSSPS 182
Query: 452 RRGQKARQKAAEAGAE----SRGDKKQGR-----QKASAAGTKSRGGGLKSHSGKNLWRR 502
Q A+ + EA A SRG + + R Q A GT R G S S
Sbjct: 183 ADQQGAQDREEEAAAAPAPTSRGHRTEKRKPQQPQCRPAGGTGQRRGSRSSPSADQ---- 238
Query: 503 GQKAEAAGEKATAAGAK-SRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGG 561
Q+A+ E+A AA A SRG + +R K +Q Q+ A
Sbjct: 239 -QRAQDREEEAAAAPAPTSRGHRTEKR---------------KPQQPQRRPA-------- 274
Query: 562 GGNKQSRGGG--------GNKPRQWGQTAAAAKTRGG----GDKQPGWQKAAAGVTKSRS 609
GG Q RG G G + R+ AA A T G K+ Q AG T R
Sbjct: 275 GGTGQRRGSGYSPSADQQGAQDREEEAAAAPAPTSSGHRTEKRKRLQLQCQPAGGTGQRR 334
Query: 610 GDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAA 669
G G + Q+ GA+ R +++AAAA ++G + +QP+ ++PAA
Sbjct: 335 GSGCSSSANQQ----GAQDR-------EEEAAAAPVPTSSGHRTEKRKPQQPQ-RRPAAG 382
Query: 670 -----GSESSAAA----AVGQEAEARKKPRR 691
GS SS +A A +E E RK +R
Sbjct: 383 TGQRRGSGSSPSADQQRAQDREEEVRKWKKR 413
Score = 86.3 bits (212), Expect = 1e-16
Identities = 83/353 (23%), Positives = 147/353 (41%), Gaps = 33/353 (9%)
Query: 82 GKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWR 141
G + R+ AA A + E++AAAA + G + R+R Q + R
Sbjct: 63 GAQDREEEAAAAPAADQQRAQDREEEAAAAPVPTSSGHRTEKRKRLQLQCQPAGGTGQRR 122
Query: 142 AQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKSR-SGKKPRRRGAKSRGD 200
+S+ + + R ++ AAAA V + G + +K + R +G +RRG+ S
Sbjct: 123 GSRSSPSADQQRAQDREEEAAAAPVPTSRGHRTEKRKRQQPQRRPAGGTGQRRGSGSSPS 182
Query: 201 EDKKG---RQREAKSRFGKTRGGRRKKHRRPKP----AAGGAKSRRGGGKKPQKQRRRGQ 253
D++G R+ EA + T G R + R+P+ AGG RRG P ++R Q
Sbjct: 183 ADQQGAQDREEEAAAAPAPTSRGHRTEKRKPQQPQCRPAGGTGQRRGSRSSPSADQQRAQ 242
Query: 254 -KAATGGKSRVGKSRGGGDKKLRRQGQNAALAG--AKRRGAATAGEKPAAKGRGGRGPKS 310
+ + SRG +K + Q AG +RRG +G P+A +G + +
Sbjct: 243 DREEEAAAAPAPTSRGHRTEKRKPQQPQRRPAGGTGQRRG---SGYSPSADQQGAQDREE 299
Query: 311 LGGQNPRWGRGGKKPRRRGQ---KATKAAAAGTKRGGGGQQKAAVVGVKSRKK------- 360
P G + +R + + A G +RG G A G + R++
Sbjct: 300 EAAAAPAPTSSGHRTEKRKRLQLQCQPAGGTGQRRGSGCSSSANQQGAQDREEEAAAAPV 359
Query: 361 --------QRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQ 405
++R+ ++P+R+ A+ G + RG G + + + + +W+
Sbjct: 360 PTSSGHRTEKRKPQQPQRRPAAGTGQR-RGSGSSPSADQQRAQDREEEVRKWK 411
Score = 81.6 bits (200), Expect = 3e-15
Identities = 109/452 (24%), Positives = 185/452 (40%), Gaps = 75/452 (16%)
Query: 204 KGRQREAKSRFGKTR----GGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGG 259
K RQ+E +R K R G + ++ + KP +PQ+Q + TG
Sbjct: 2 KPRQKEQDTRLRKLRESSEGDQWLENEKTKPL------------RPQQQPQCQPAGGTGQ 49
Query: 260 KSRVGKSRGGGDKKLRRQGQNAALAGA-------KRRGAATAGEKPAAKGRGGRGPKSLG 312
+ G S + + + + AA A A R A A P + G K L
Sbjct: 50 RRGSGSSPSADQQGAQDREEEAAAAPAADQQRAQDREEEAAAAPVPTSSGHRTEKRKRLQ 109
Query: 313 GQ-NPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGV---KSRKKQRRRGKKP 368
Q P G G +RRG ++ + +A +R +++AA V + + ++R+ ++P
Sbjct: 110 LQCQPAGGTG----QRRGSRS--SPSADQQRAQDREEEAAAAPVPTSRGHRTEKRKRQQP 163
Query: 369 RRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPR 428
+R+ A G + RG G A ++G Q+ A APA RG ++K +
Sbjct: 164 QRRPAGGTGQR-RGSGSSP---SADQQGA-------QDREEEAAAAPAPTSRGHRTEKRK 212
Query: 429 RRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGA----ESRGDKKQGR-----QKA 479
+ P+ + G R G P Q+A+ + EA A SRG + + R Q+
Sbjct: 213 PQQPQCRPAGGTGQRRGSRSSPSADQQRAQDREEEAAAAPAPTSRGHRTEKRKPQQPQRR 272
Query: 480 SAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKA-TAAGAKSRGRKQPRRQKPAVAGAKS 538
A GT R G S S + ++ EAA A T++G ++ RK+ + Q G
Sbjct: 273 PAGGTGQRRGSGYSPSADQQGAQDREEEAAAAPAPTSSGHRTEKRKRLQLQCQPAGGTGQ 332
Query: 539 RVG----------GSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTR 588
R G G++ R+ + A A TS G K+ KP+Q + AA
Sbjct: 333 RRGSGCSSSANQQGAQDREEEAAAAPVPTSSGHRTEKR-------KPQQPQRRPAA---- 381
Query: 589 GGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQK 620
G G ++ +A +++ + + W+++
Sbjct: 382 GTGQRRGSGSSPSADQQRAQDREEEVRKWKKR 413
Score = 77.8 bits (190), Expect = 4e-14
Identities = 97/403 (24%), Positives = 164/403 (40%), Gaps = 38/403 (9%)
Query: 107 KAAAAGTKSLGGRGRKPRRRGQK-----AAATGSKKPRWRAQKSAAAGSKNRGAGAQKAA 161
+ ++ G + L KP R Q+ A TG ++ + + G+++R A AA
Sbjct: 16 RESSEGDQWLENEKTKPLRPQQQPQCQPAGGTGQRRGSGSSPSADQQGAQDREEEA--AA 73
Query: 162 AAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGR 221
A A + + ++ ++AAAA + SG + +R + G + SR + +
Sbjct: 74 APAADQQRAQDREEEAAAAPVPTSSGHRTEKRKRLQLQCQPAGGTGQRRGSRSSPSADQQ 133
Query: 222 RKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNA 281
R + R + AA + R G + +++R++ Q+ GG G+ RG G +A
Sbjct: 134 RAQDREEEAAAAPVPTSR-GHRTEKRKRQQPQRRPAGG---TGQRRGSG------SSPSA 183
Query: 282 ALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTK 341
GA+ R A PA RG R K Q P+ G +RRG ++ + +A +
Sbjct: 184 DQQGAQDR-EEEAAAAPAPTSRGHRTEKR-KPQQPQCRPAGGTGQRRGSRS--SPSADQQ 239
Query: 342 RGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKK 401
R +++AA + + R +KP++ + AG G G ++G +
Sbjct: 240 RAQDREEEAAAAPAPTSRGHRTEKRKPQQPQRRPAG----GTGQRRG----SGYSPSADQ 291
Query: 402 PRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKA 461
Q+ A APA G ++K +R + + G R G G Q A+ +
Sbjct: 292 QGAQDREEEAAAAPAPTSSGHRTEKRKRLQLQCQPAGGTGQRRGSGCSSSANQQGAQDRE 351
Query: 462 AEA---------GAESRGDKKQGRQKASAAGTKSRGGGLKSHS 495
EA G + K Q Q+ AAGT R G S S
Sbjct: 352 EEAAAAPVPTSSGHRTEKRKPQQPQRRPAAGTGQRRGSGSSPS 394
Score = 75.9 bits (185), Expect = 1e-13
Identities = 101/394 (25%), Positives = 163/394 (41%), Gaps = 55/394 (13%)
Query: 8 QCNQAAG---RAGPGAPLGAALARTPVELAAESAAPALSA---------AAAGVKILGSG 55
QC A G R G G+ A +AAPA AAA SG
Sbjct: 40 QCQPAGGTGQRRGSGSSPSADQQGAQDREEEAAAAPAADQQRAQDREEEAAAAPVPTSSG 99
Query: 56 DKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKS 115
+ +R K+ +L+ Q G+ +A A++R E++AAAA +
Sbjct: 100 HRTEKR-------KRLQLQCQPAGGTGQRRGSRSSPSADQQRAQDR---EEEAAAAPVPT 149
Query: 116 LGGRGRKPRRRGQK----AAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGG 171
G + R+R Q A TG ++ + + G+++R ++ AAAA + G
Sbjct: 150 SRGHRTEKRKRQQPQRRPAGGTGQRRGSGSSPSADQQGAQDR----EEEAAAAPAPTSRG 205
Query: 172 EKPQKAAAAGAKSR-SGKKPRRRGAKSRGDEDK---KGRQREAKSRFGKTRGGRRKKHRR 227
+ +K + R +G +RRG++S D+ + R+ EA + T G R + R+
Sbjct: 206 HRTEKRKPQQPQCRPAGGTGQRRGSRSSPSADQQRAQDREEEAAAAPAPTSRGHRTEKRK 265
Query: 228 P----KPAAGGAKSRRGGGKKP----QKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQ 279
P + AGG RRG G P Q + R ++AA R K+L+ Q Q
Sbjct: 266 PQQPQRRPAGGTGQRRGSGYSPSADQQGAQDREEEAAAAPAPTSSGHRTEKRKRLQLQCQ 325
Query: 280 NAALAGAKR-RGAATAGEKPAAKGRGGRG-----PKSLGGQNPRWGRGGKKPRRRGQKAT 333
A G +R G +++ + A+ R P S G + + R ++P+RR
Sbjct: 326 PAGGTGQRRGSGCSSSANQQGAQDREEEAAAAPVPTSSGHRTEK--RKPQQPQRR----- 378
Query: 334 KAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKK 367
AA G +RG G A + R+++ R+ KK
Sbjct: 379 PAAGTGQRRGSGSSPSADQQRAQDREEEVRKWKK 412
Score = 74.3 bits (181), Expect = 4e-13
Identities = 87/378 (23%), Positives = 141/378 (37%), Gaps = 31/378 (8%)
Query: 426 KPRR--RGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKK--QGRQKASA 481
KP R + P+ + G R G G P Q A+ + EA A D++ Q R++ +A
Sbjct: 31 KPLRPQQQPQCQPAGGTGQRRGSGSSPSADQQGAQDREEEAAAAPAADQQRAQDREEEAA 90
Query: 482 AGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKS--RGRKQPRRQKPAVAGAKS- 538
A G ++ K L + Q A G++ + + S + R Q R ++ A A +
Sbjct: 91 AAPVPTSSGHRTEKRKRLQLQCQPAGGTGQRRGSRSSPSADQQRAQDREEEAAAAPVPTS 150
Query: 539 ---RVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGG---- 591
R K +Q Q+ A G G G+ S G + R+ AA A T G
Sbjct: 151 RGHRTEKRKRQQPQRRPAGGTGQRRGSGSSPSADQQGAQDREEEAAAAPAPTSRGHRTEK 210
Query: 592 --DKQPGWQKAAA-----GVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAE 644
+QP + A G S S D + R++ A + R ++ +
Sbjct: 211 RKPQQPQCRPAGGTGQRRGSRSSPSADQQRAQDREEEAAAAPAPTSRGHRTEKRKPQQPQ 270
Query: 645 KAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRR--AKSRGDGGQ 702
+ A G R G P + A E AAAA + + +R+R + + GG
Sbjct: 271 RRPAGGTGQRRGSGYSPSADQQGAQDREEEAAAAPAPTSSGHRTEKRKRLQLQCQPAGGT 330
Query: 703 NAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGG 762
QRRG ++ G + + A S G ++ K + G
Sbjct: 331 G--------QRRGSGCSSSANQQGAQDREEEAAAAPVPTSSGHRTEKRKPQQPQRRPAAG 382
Query: 763 GAKRRRGGGAKSRSGEKA 780
+RR G + S ++A
Sbjct: 383 TGQRRGSGSSPSADQQRA 400
>gi|239752579 PREDICTED: hypothetical protein XP_002348295 [Homo
sapiens]
Length = 240
Score = 87.8 bits (216), Expect = 4e-17
Identities = 69/171 (40%), Positives = 85/171 (49%), Gaps = 19/171 (11%)
Query: 364 RGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRW---QNPRRRAQKAPAAKP- 419
RG+ RR +AA + G G R R PR Q+ R + ++P
Sbjct: 84 RGRAQRRSMHAAAAQERSLGRGCLGKEPPNRESWTRSDPRHCISQDASRSGSRVCRSRPQ 143
Query: 420 -RGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQK 478
RG G KK R+RG KAA K+ SG KKP RQKAA GA+SRG + + QK
Sbjct: 144 TRGSGGKKLRQRGEKAAAV---KTCSGRSKKP------GRQKAAVMGAKSRGGRGKKPQK 194
Query: 479 ASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQ 529
A+AAG KS GG GK L R G+K G+KA GAKSR + Q R Q
Sbjct: 195 AAAAGAKSCNGG-----GKKLGRWGKKPGRRGQKAAVTGAKSRKKPQRRGQ 240
Score = 83.6 bits (205), Expect = 7e-16
Identities = 64/163 (39%), Positives = 81/163 (49%), Gaps = 12/163 (7%)
Query: 141 RAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGD 200
R+ +AAA ++ G G +S P+ + A SRSG + R ++RG
Sbjct: 90 RSMHAAAAQERSLGRGCL-GKEPPNRESWTRSDPRHCISQDA-SRSGSRVCRSRPQTRGS 147
Query: 201 EDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGK 260
KK RQR K+ KT GR KK R K A GAKSR G GKKPQK G K+ GG
Sbjct: 148 GGKKLRQRGEKAAAVKTCSGRSKKPGRQKAAVMGAKSRGGRGKKPQKAAAAGAKSCNGG- 206
Query: 261 SRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGR 303
GK G KK R+GQ AA+ GAK R +KP +G+
Sbjct: 207 ---GKKLGRWGKKPGRRGQKAAVTGAKSR------KKPQRRGQ 240
Score = 79.0 bits (193), Expect = 2e-14
Identities = 63/166 (37%), Positives = 79/166 (47%), Gaps = 19/166 (11%)
Query: 493 SHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAV 552
SH G+ RR A AA E++ G G++ P R+ + + + SR +
Sbjct: 82 SHRGR-AQRRSMHAAAAQERSLGRGCL--GKEPPNRESWTRSDPRHCISQDASRSGSRVC 138
Query: 553 AAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDG 612
+ Q+RG GG K RQ G+ AAA KT G K+PG QKAA KSR G G
Sbjct: 139 RS---------RPQTRGSGGKKLRQRGEKAAAVKTCSGRSKKPGRQKAAVMGAKSRGGRG 189
Query: 613 GKKAWRQKAAGTGAKS----RKKPWRRGQKDAAAAEKAWATGATSR 654
K QKAA GAKS KK R G+K +KA TGA SR
Sbjct: 190 KKP---QKAAAAGAKSCNGGGKKLGRWGKKPGRRGQKAAVTGAKSR 232
Score = 78.2 bits (191), Expect = 3e-14
Identities = 72/214 (33%), Positives = 91/214 (42%), Gaps = 64/214 (29%)
Query: 247 KQRRRGQKAATG-----GKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAK 301
+ +RR AA G+ +GK + R ++ A R G+ +P +
Sbjct: 86 RAQRRSMHAAAAQERSLGRGCLGKEPPNRESWTRSDPRHCISQDASRSGSRVCRSRPQTR 145
Query: 302 GRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQ 361
G GG KK R+RG+KA + G+QKAAV+G KSR
Sbjct: 146 GSGG-----------------KKLRQRGEKAAAVKTCSGRSKKPGRQKAAVMGAKSR--- 185
Query: 362 RRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRG 421
RGKKP QKA+AAGAKS GG G+K RW
Sbjct: 186 GGRGKKP--QKAAAAGAKSCNGG-------------GKKLGRW----------------- 213
Query: 422 GGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQ 455
KKP RRG KAA + G KSR KKP+RRGQ
Sbjct: 214 --GKKPGRRGQKAAVT-GAKSR----KKPQRRGQ 240
Score = 71.2 bits (173), Expect = 4e-12
Identities = 74/229 (32%), Positives = 92/229 (40%), Gaps = 60/229 (26%)
Query: 410 RAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESR 469
R A A P + RR AA R GK+P R R ++
Sbjct: 71 RVTPATALLPLSHRGRAQRRSMHAAAAQERSLGRGCLGKEPPNRESWTRSDPRHCISQ-- 128
Query: 470 GDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQ 529
D + + + ++RG G G+K GEKA A S K+P RQ
Sbjct: 129 -DASRSGSRVCRSRPQTRGSG------------GKKLRQRGEKAAAVKTCSGRSKKPGRQ 175
Query: 530 KPAVAGAKSRVGGSKSRQRQKAVAAGA-TSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTR 588
K AV GAKSR G + ++ QKA AAGA + + GGG K +WG
Sbjct: 176 KAAVMGAKSR--GGRGKKPQKAAAAGAKSCN----------GGGKKLGRWG--------- 214
Query: 589 GGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQ 637
K+PG R G QKAA TGAKSRKKP RRGQ
Sbjct: 215 ----KKPG-----------RRG--------QKAAVTGAKSRKKPQRRGQ 240
Score = 68.6 bits (166), Expect = 2e-11
Identities = 58/160 (36%), Positives = 74/160 (46%), Gaps = 17/160 (10%)
Query: 1 MDYRGHRQCNQAAGRAGPGAPLG-AALARTPVELAAESAAPALSAAAAGVKILGSGDKKL 59
+ +RG Q A LG L + P + + + + GS +
Sbjct: 81 LSHRGRAQRRSMHAAAAQERSLGRGCLGKEPPNRESWTRSDPRHCISQDASRSGSRVCRS 140
Query: 60 RRQKAAAGGKKARLRGQKGAV----AGKEARQHWQKAA--GAGGAENRGGGEQKAAAAGT 113
R Q +GGKK R RG+K A +G+ + QKAA GA RG QKAAAAG
Sbjct: 141 RPQTRGSGGKKLRQRGEKAAAVKTCSGRSKKPGRQKAAVMGAKSRGGRGKKPQKAAAAGA 200
Query: 114 KS-------LGGRGRKPRRRGQKAAATGS---KKPRWRAQ 143
KS LG G+KP RRGQKAA TG+ KKP+ R Q
Sbjct: 201 KSCNGGGKKLGRWGKKPGRRGQKAAVTGAKSRKKPQRRGQ 240
Score = 62.4 bits (150), Expect = 2e-09
Identities = 65/182 (35%), Positives = 92/182 (50%), Gaps = 43/182 (23%)
Query: 42 LSAAAAGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEA--RQHWQKAAGAGGAE 99
++ A A + + G + R AAA +++ RG GKE R+ W ++ +
Sbjct: 72 VTPATALLPLSHRGRAQRRSMHAAAAQERSLGRG----CLGKEPPNRESWTRS------D 121
Query: 100 NRGGGEQKAAAAGTK-------SLGGRGRKPRRRGQKAAATG-----SKKPRWRAQKSAA 147
R Q A+ +G++ + G G+K R+RG+KAAA SKKP QK+A
Sbjct: 122 PRHCISQDASRSGSRVCRSRPQTRGSGGKKLRQRGEKAAAVKTCSGRSKKPG--RQKAAV 179
Query: 148 AGSKNRGAGAQKA--AAAAGVKS---------QGGEKP----QKAAAAGAKSRSGKKPRR 192
G+K+RG +K AAAAG KS + G+KP QKAA GAKSR KKP+R
Sbjct: 180 MGAKSRGGRGKKPQKAAAAGAKSCNGGGKKLGRWGKKPGRRGQKAAVTGAKSR--KKPQR 237
Query: 193 RG 194
RG
Sbjct: 238 RG 239
Score = 55.8 bits (133), Expect = 2e-07
Identities = 55/175 (31%), Positives = 78/175 (44%), Gaps = 26/175 (14%)
Query: 629 RKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAE-ARK 687
R + RR AAA E++ RG GK+P ++ + + S + Q+A +
Sbjct: 84 RGRAQRRSMHAAAAQERS-----LGRGCLGKEPPNRE---SWTRSDPRHCISQDASRSGS 135
Query: 688 KPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGG----GAKSRGSGGAKSRGSG 743
+ R R ++RG GG+ ++RG+K K+ G G + GAKSRG
Sbjct: 136 RVCRSRPQTRGSGGKKL-------RQRGEKAAAVKTCSGRSKKPGRQKAAVMGAKSRGGR 188
Query: 744 GAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPR 798
G K + AA +KS GGG K R G R G+KA G A KKP R
Sbjct: 189 GKKPQKA-AAAGAKSCNGGGKKLGRWGKKPGRRGQKAAVTG-----AKSRKKPQR 237
Score = 54.7 bits (130), Expect = 3e-07
Identities = 58/175 (33%), Positives = 80/175 (45%), Gaps = 38/175 (21%)
Query: 100 NRGGGEQKA--AAAGTKSLGGR---GRKPRRR------------GQKAAATGSKKPRWRA 142
+RG ++++ AAA + GR G++P R Q A+ +GS+ R R
Sbjct: 83 HRGRAQRRSMHAAAAQERSLGRGCLGKEPPNRESWTRSDPRHCISQDASRSGSRVCRSRP 142
Query: 143 QKSAAAGSKNRGAGAQKAAAAAGVKSQGG--EKP--QKAAAAGAKSRSGKKPRRRGAKSR 198
Q + G K R Q+ AA VK+ G +KP QKAA GAKSR G R
Sbjct: 143 QTRGSGGKKLR----QRGEKAAAVKTCSGRSKKPGRQKAAVMGAKSRGG----------R 188
Query: 199 GDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQ 253
G + +K AKS G GG++ KP G K+ G K +K +RRGQ
Sbjct: 189 GKKPQKAAAAGAKSCNG---GGKKLGRWGKKPGRRGQKAAVTGAKSRKKPQRRGQ 240
Score = 52.4 bits (124), Expect = 2e-06
Identities = 44/96 (45%), Positives = 50/96 (52%), Gaps = 14/96 (14%)
Query: 738 KSRGSGGAKSRS-GKKAAASKSHGGGGAKRRRGG----GAKSRSGE----KAVTAGGQKA 788
++RGSGG K R G+KAAA K+ G K R GAKSR G + A G K+
Sbjct: 143 QTRGSGGKKLRQRGEKAAAVKTCSGRSKKPGRQKAAVMGAKSRGGRGKKPQKAAAAGAKS 202
Query: 789 AAAGGKKPPRV-KSRGGRGQKAAAGG----KKPLRR 819
GGKK R K G RGQKAA G KKP RR
Sbjct: 203 CNGGGKKLGRWGKKPGRRGQKAAVTGAKSRKKPQRR 238
>gi|239752632 PREDICTED: hypothetical protein XP_002347697 [Homo
sapiens]
Length = 231
Score = 85.5 bits (210), Expect = 2e-16
Identities = 72/160 (45%), Positives = 83/160 (51%), Gaps = 22/160 (13%)
Query: 364 RGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRW---QNPRRRAQKAPAAKP- 419
RG+ RR +AA + G G K R PR Q+ R + ++P
Sbjct: 84 RGQVQRRSMQAAAAQEQSLGRGCLGKEPPKWESSTRSGPRRCLSQDASRSGSRVCRSRPQ 143
Query: 420 -RGGGSKKPRRRGPKA----AKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQ 474
RGGG KKP RRG KA AKSRGG RS GGKK RRRG QKAA AGA+S G +
Sbjct: 144 TRGGGGKKP-RRGQKAATAGAKSRGGGVRSRGGKKIRRRG----QKAAAAGAKSCGGGGK 198
Query: 475 GRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAA-GEKA 513
QKA A G + RG K L RRG+KA AA GEKA
Sbjct: 199 KPQKARAVGARRRG-------WKKLRRRGKKAAAAGGEKA 231
Score = 76.6 bits (187), Expect = 8e-14
Identities = 69/169 (40%), Positives = 82/169 (48%), Gaps = 31/169 (18%)
Query: 184 SRSGKKPRRRGAKSRGDEDKKGRQ---REAKSRFGKTRGGRRKKHRRPKPAAGGA----- 235
S G+ RR + E GR +E TR G R+ + +G
Sbjct: 82 SHRGQVQRRSMQAAAAQEQSLGRGCLGKEPPKWESSTRSGPRRCLSQDASRSGSRVCRSR 141
Query: 236 -KSRRGGGKKPQKQRRRGQKAATGG-KSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAAT 293
++R GGGKKP RRGQKAAT G KSR G R G KK+RR+GQ AA AGAK G
Sbjct: 142 PQTRGGGGKKP----RRGQKAATAGAKSRGGGVRSRGGKKIRRRGQKAAAAGAKSCGG-- 195
Query: 294 AGEKP-AAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTK 341
G+KP A+ G R RG KK RRRG+KA AAA G K
Sbjct: 196 GGKKPQKARAVGAR------------RRGWKKLRRRGKKA--AAAGGEK 230
Score = 75.5 bits (184), Expect = 2e-13
Identities = 62/166 (37%), Positives = 84/166 (50%), Gaps = 28/166 (16%)
Query: 634 RRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAE-ARKKPRRR 692
RR + AAA E++ G G + P+W+ +G + Q+A + + R
Sbjct: 89 RRSMQAAAAQEQSLGRGCL----GKEPPKWESSTRSGPRR----CLSQDASRSGSRVCRS 140
Query: 693 RAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKK 752
R ++RG GG KKPR G+ GAKSRG GG +SRG + R K
Sbjct: 141 RPQTRGGGG--------------KKPRRGQKAATAGAKSRG-GGVRSRGGKKIRRRGQKA 185
Query: 753 AAA-SKSHGGGGAK--RRRGGGAKSRSGEKAVTAGGQKAAAAGGKK 795
AAA +KS GGGG K + R GA+ R G K + G+KAAAAGG+K
Sbjct: 186 AAAGAKSCGGGGKKPQKARAVGARRR-GWKKLRRRGKKAAAAGGEK 230
Score = 73.9 bits (180), Expect = 5e-13
Identities = 69/186 (37%), Positives = 83/186 (44%), Gaps = 47/186 (25%)
Query: 246 QKQRRRGQKAATG----GKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAK 301
Q QRR Q AA G+ +GK + R + A R G+ +P +
Sbjct: 86 QVQRRSMQAAAAQEQSLGRGCLGKEPPKWESSTRSGPRRCLSQDASRSGSRVCRSRPQTR 145
Query: 302 GRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSR--K 359
G GG+ P RRGQKA A AG K GGG V+SR K
Sbjct: 146 GGGGKKP------------------RRGQKA---ATAGAKSRGGG--------VRSRGGK 176
Query: 360 KQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKP 419
K RRRG QKA+AAGAKS GGG KK K R G ++ W+ RRR +KA AA
Sbjct: 177 KIRRRG-----QKAAAAGAKSCGGGGKK---PQKARAVGARRRGWKKLRRRGKKAAAA-- 226
Query: 420 RGGGSK 425
GG K
Sbjct: 227 --GGEK 230
Score = 73.2 bits (178), Expect = 9e-13
Identities = 58/159 (36%), Positives = 78/159 (49%), Gaps = 28/159 (17%)
Query: 41 ALSAAAAGVKILGSG--DKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGA 98
++ AAAA + LG G K+ + +++ R Q + +G + + G GG
Sbjct: 91 SMQAAAAQEQSLGRGCLGKEPPKWESSTRSGPRRCLSQDASRSGSRVCRSRPQTRGGGGK 150
Query: 99 ENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQ 158
+ R G QKAA AG KS GG R + G KK R R QK+AAAG+K+ G G
Sbjct: 151 KPRRG--QKAATAGAKSRGGGVR----------SRGGKKIRRRGQKAAAAGAKSCGGG-- 196
Query: 159 KAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKS 197
G+KPQKA A GA+ R KK RRRG K+
Sbjct: 197 ------------GKKPQKARAVGARRRGWKKLRRRGKKA 223
Score = 70.1 bits (170), Expect = 8e-12
Identities = 57/166 (34%), Positives = 76/166 (45%), Gaps = 21/166 (12%)
Query: 1 MDYRGHRQCNQAAGRAGPGAPLG-AALARTPVELAAESAAPALSAAAAGVKILGSGDKKL 59
+ +RG Q A LG L + P + + + + + GS +
Sbjct: 81 LSHRGQVQRRSMQAAAAQEQSLGRGCLGKEPPKWESSTRSGPRRCLSQDASRSGSRVCRS 140
Query: 60 RRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGE-----QKAAAAGTK 114
R Q GGKK R RGQK A AG ++R GG +RGG + QKAAAAG K
Sbjct: 141 RPQTRGGGGKKPR-RGQKAATAGAKSR--------GGGVRSRGGKKIRRRGQKAAAAGAK 191
Query: 115 SLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKA 160
S GG G+KP QKA A G+++ W+ K G K AG +KA
Sbjct: 192 SCGGGGKKP----QKARAVGARRRGWK--KLRRRGKKAAAAGGEKA 231
Score = 70.1 bits (170), Expect = 8e-12
Identities = 72/210 (34%), Positives = 89/210 (42%), Gaps = 67/210 (31%)
Query: 82 GKEARQHWQKAAGAGGAENRG--GGEQKAAAAGTKSLGGRGRKPRR-RGQKAAATGSKKP 138
G+ R+ Q AA + RG G E + T+S PRR Q A+ +GS+
Sbjct: 85 GQVQRRSMQAAAAQEQSLGRGCLGKEPPKWESSTRS------GPRRCLSQDASRSGSRVC 138
Query: 139 RWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSR 198
R R Q G K R + AA AG KS+GG G +SR GKK RRRG K+
Sbjct: 139 RSRPQTRGGGGKKPRRG---QKAATAGAKSRGG---------GVRSRGGKKIRRRGQKA- 185
Query: 199 GDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATG 258
AA GAKS GGGKKPQK R A G
Sbjct: 186 --------------------------------AAAGAKSCGGGGKKPQKAR------AVG 207
Query: 259 GKSRVGKSRGGGDKKLRRQGQNAALAGAKR 288
+ R G KKLRR+G+ AA AG ++
Sbjct: 208 ARRR-------GWKKLRRRGKKAAAAGGEK 230
Score = 64.7 bits (156), Expect = 3e-10
Identities = 64/183 (34%), Positives = 82/183 (44%), Gaps = 40/183 (21%)
Query: 469 RGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRR 528
RG ++ +A+AA +S G G W + + +G + + SR + R
Sbjct: 84 RGQVQRRSMQAAAAQEQSLGRGCLGKEPPK-W---ESSTRSGPRRCLSQDASRSGSRVCR 139
Query: 529 QKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAA--K 586
+P G GG K R+ QKA AGA S GGG R GG K R+ GQ AAAA K
Sbjct: 140 SRPQTRGG----GGKKPRRGQKAATAGAKSRGGG----VRSRGGKKIRRRGQKAAAAGAK 191
Query: 587 TRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSR--KKPWRRGQKDAAA-A 643
+ GGG K+P QKA GA+ R KK RRG+K AAA
Sbjct: 192 SCGGGGKKP-----------------------QKARAVGARRRGWKKLRRRGKKAAAAGG 228
Query: 644 EKA 646
EKA
Sbjct: 229 EKA 231
Score = 64.3 bits (155), Expect = 4e-10
Identities = 58/168 (34%), Positives = 75/168 (44%), Gaps = 28/168 (16%)
Query: 428 RRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSR 487
RR AA R GK+P + R ++ D + + + ++R
Sbjct: 89 RRSMQAAAAQEQSLGRGCLGKEPPKWESSTRSGPRRCLSQ---DASRSGSRVCRSRPQTR 145
Query: 488 GGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRR--QKPAVAGAKSRVGGSKS 545
GGG K RRGQKA AG K+ G +SRG K+ RR QK A AGAKS GG K
Sbjct: 146 GGGGKKP------RRGQKAATAGAKSRGGGVRSRGGKKIRRRGQKAAAAGAKSCGGGGKK 199
Query: 546 RQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDK 593
Q+ +AV A R G K R+ G+ AAAA GG+K
Sbjct: 200 PQKARAVGA-------------RRRGWKKLRRRGKKAAAA----GGEK 230
Score = 62.0 bits (149), Expect = 2e-09
Identities = 55/175 (31%), Positives = 76/175 (43%), Gaps = 45/175 (25%)
Query: 657 GGKQPRWQKPAAAGSESSAAAAVGQE-----AEARKKPRRRRAKSRGDGGQNAAVGINPW 711
G Q R + AAA +S +G+E + R PRR ++ G
Sbjct: 85 GQVQRRSMQAAAAQEQSLGRGCLGKEPPKWESSTRSGPRRCLSQDASRSGS--------- 135
Query: 712 QRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGG 771
R+ +SR ++RG GG K R G+KAA + + GG R RGG
Sbjct: 136 -------RVCRSR------------PQTRGGGGKKPRRGQKAATAGAKSRGGGVRSRGGK 176
Query: 772 AKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGR----------GQKAA-AGGKK 815
R G+KA AG K+ GGKKP + ++ G R G+KAA AGG+K
Sbjct: 177 KIRRRGQKAAAAGA-KSCGGGGKKPQKARAVGARRRGWKKLRRRGKKAAAAGGEK 230
Score = 57.0 bits (136), Expect = 7e-08
Identities = 58/171 (33%), Positives = 72/171 (42%), Gaps = 32/171 (18%)
Query: 542 GSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAA 601
G R+ +A AA S G RG G +P +W + TR G +
Sbjct: 85 GQVQRRSMQAAAAQEQSLG-------RGCLGKEPPKW-----ESSTRSG-------PRRC 125
Query: 602 AGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQP 661
SRSG ++ Q G G KKP RRGQK A A K+ G SRG +
Sbjct: 126 LSQDASRSGSRVCRSRPQTRGGGG----KKP-RRGQKAATAGAKSRGGGVRSRGGKKIRR 180
Query: 662 RWQKPAAAGSES--------SAAAAVGQEAEARKKPRRRRAKSRGDGGQNA 704
R QK AAAG++S A AVG KK RRR K+ GG+ A
Sbjct: 181 RGQKAAAAGAKSCGGGGKKPQKARAVGARRRGWKKLRRRGKKAAAAGGEKA 231
>gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens]
Length = 1312
Score = 84.3 bits (207), Expect = 4e-16
Identities = 117/528 (22%), Positives = 204/528 (38%), Gaps = 71/528 (13%)
Query: 329 GQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKG 388
G+ A AA ++ GG ++ + + R +QR P A+AAG +R KK
Sbjct: 464 GEPAPAPPAADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTR----KKS 519
Query: 389 LREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRR----GPKAAKSRGGKSRS 444
RE KR G+ ++ + + A APA+ SKK R R G A+ S +SRS
Sbjct: 520 RRERKRSGEAKEAASSSSGTQPAPPAPASP---WDSKKHRSRDRKPGSHASSSARRRSRS 576
Query: 445 GGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQ 504
+ RR ++ + SR +K+ R++ SA+ + S S + RG+
Sbjct: 577 RSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPATS---SSSSSRRERHRGK 633
Query: 505 KAEAAGEKATAAGAKSRGRKQ-----PRRQKPAVAGAKSRVGGSKSRQRQKAV------- 552
+ G K ++SRG K+ + PA + S G + +R+ AV
Sbjct: 634 HRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDL 693
Query: 553 ------AAGATSHGGGGNKQSRGGGGNKPRQ-------WGQTAAAAKTRGGGDKQPGWQK 599
A T G +K G P + + + RGG Q ++
Sbjct: 694 TDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQKDRRR 753
Query: 600 AAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGK 659
+ A + S S + G R+KA G + R R +D + K S S G
Sbjct: 754 SGAASSSSSSREKGS---RRKALDGGDRDRD---RDRDRDRDRSSKKARPPKESAPSSGP 807
Query: 660 QPRWQKPAAAGSESSAAAAVGQEAEARKKPR---RRRAKSRGDGGQNAAVGI-------- 708
P+ + +GS SS+++ ++ + + K R S A+ G+
Sbjct: 808 PPKPPVSSGSGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFS 867
Query: 709 ------NPWQRRGKKPRLGKSRGGGGA------KSRGSGGAKSRGSGGAKSRSGKKAAAS 756
+P+ + ++ ++ G+ K + GAK K++ K
Sbjct: 868 RDRESRSPFLKPDERAPTEMAKAAPGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKV 927
Query: 757 KSHGGGGAKRRRGGGAKSRS---GEKAVTAGGQKAAAAGGKKPPRVKS 801
+S GG G + KS++ + A T G ++ + +G ++ +V S
Sbjct: 928 RSGGGSGGSGGQVSLKKSKADSCSQAAGTKGAEETSWSGEERAAKVPS 975
Score = 79.3 bits (194), Expect = 1e-14
Identities = 130/542 (23%), Positives = 203/542 (37%), Gaps = 74/542 (13%)
Query: 90 QKAAGAGGAENRGGG---EQKAAAAGTKSLGGRGRKPRRRGQKAAATG------SKKPRW 140
+ A A++R GG +K + R P AAA G S++ R
Sbjct: 465 EPAPAPPAADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERK 524
Query: 141 RAQKSAAAGSKNRGAGAQKAAAAAGVKSQG----GEKPQKAAAAGAKSRSGKKPRRRGAK 196
R+ ++ A S + G A A+ S+ KP A++ A+ RS + R R +
Sbjct: 525 RSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTR 584
Query: 197 --SRGDEDKKGRQREAKSRFGKTRGGRRKKHRR------PKPAAGGAKSRRGGGKKPQKQ 248
SR + ++G R ++SR +K RR P PA + S R ++
Sbjct: 585 RRSRSTDRRRGGSRRSRSR---------EKRRRRRRSASPPPATSSSSSSR-------RE 628
Query: 249 RRRGQKAATGG-KSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRG 307
R RG+ GG K + +SR G+K+ + A G+ + G++ + R G
Sbjct: 629 RHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSR--RRGAV 686
Query: 308 PKSLGGQN-------PRWGRGGKKPRRRGQKATKAAAAGTKR-------GGGGQQKAAVV 353
P S+ R G+ + + + A A+ KR G G+++
Sbjct: 687 PPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLSGEER---- 742
Query: 354 GVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGD-GRKKPRWQNPRRRAQ 412
G KS +K RRR S A + S +K R+A GD R + R ++ R ++
Sbjct: 743 GGKSSQKDRRR---------SGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDRSSK 793
Query: 413 KAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDK 472
KA K S P PK S G S S R+ K + K A E
Sbjct: 794 KARPPKESAPSSGPP----PKPPVSSGSGSSSSSSSCSSRK-VKLQSKVAVLIREGVSST 848
Query: 473 KQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPA 532
+ AS AG S G A E A AA ++ +K + K
Sbjct: 849 TPAKDAAS-AGLGSIGVKFSRDRESRSPFLKPDERAPTEMAKAAPGSTKPKKTKVKAKAG 907
Query: 533 VAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGD 592
K G +K + +K V +G S G GG + + Q T A +T G+
Sbjct: 908 AKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKKSKADSCSQAAGTKGAEETSWSGE 967
Query: 593 KQ 594
++
Sbjct: 968 ER 969
Score = 57.8 bits (138), Expect = 4e-08
Identities = 114/486 (23%), Positives = 169/486 (34%), Gaps = 119/486 (24%)
Query: 411 AQKAPAAKPRGGG-----------SKKPRRRGPKAAKSRGGKSRSGGG-KKPRRRGQKAR 458
A PAA R GG ++ R+R P A + + +G +K RR +K
Sbjct: 467 APAPPAADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRS 526
Query: 459 QKAAEAGAESRGDKKQGRQKASAAGTK---SRGGGLKSHSGKNLWRRGQKAEAAGEKATA 515
+A EA + S G + AS +K SR SH+ + RR + ++ +
Sbjct: 527 GEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRS------RSRS 580
Query: 516 AGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQS-----RGG 570
+ R R RR+ +SR + R+R+ A ATS ++ R G
Sbjct: 581 RSTRRRSRSTDRRRG---GSRRSRSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDG 637
Query: 571 GGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKS-- 628
GG+K ++ ++R G+K RSGDG +KA +G+ S
Sbjct: 638 GGSKKKK-------KRSRSRGEK--------------RSGDGSEKAPAPAPPPSGSTSCG 676
Query: 629 RKKPWRRG----------QKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGS------- 671
+ RRG D A ++ G + PR PA A S
Sbjct: 677 DRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDK----SDPRGPSPAPASSPKREVLY 732
Query: 672 -----------------ESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRR 714
+ + A + +R+K RR+A GD ++ R
Sbjct: 733 DSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRD-RDRDRS 791
Query: 715 GKKPRLGKSRGGGGAK------SRGSGGAKSRGS-----------------GGAKSRSGK 751
KK R K S GSG + S S G S +
Sbjct: 792 SKKARPPKESAPSSGPPPKPPVSSGSGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPA 851
Query: 752 KAAASKSHGGGGAKRRRGGGAKS---RSGEKAVTAGGQKAAAAGGKKPPRVKSRGGRGQK 808
K AAS G G K R ++S + E+A T AA G KP + K + G K
Sbjct: 852 KDAASAGLGSIGVKFSRDRESRSPFLKPDERAPTE--MAKAAPGSTKPKKTKVKAKAGAK 909
Query: 809 AAAGGK 814
G K
Sbjct: 910 KTKGTK 915
Score = 42.4 bits (98), Expect = 0.002
Identities = 56/263 (21%), Positives = 89/263 (33%), Gaps = 64/263 (24%)
Query: 621 AAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQ------KPAAAGSESS 674
AA G +RKK R ++ A E A ++ T W + GS +S
Sbjct: 508 AAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHAS 567
Query: 675 AAAAVGQEAEARKKPRRRRAKS----RGDGGQNAAVGINPWQRRGKKP------------ 718
++A + +R + RRR++S RG ++ + +RR P
Sbjct: 568 SSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPATSSSSSSRR 627
Query: 719 --RLGKSRGGGGAKSRG----SGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGA 772
GK R GGG+K + S G K G G K+ + + + G RRRG
Sbjct: 628 ERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVP 687
Query: 773 KSRSG---------EKAVTAG---------------------------GQKAAAAGGKKP 796
S ++ +T G G GGK
Sbjct: 688 PSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSS 747
Query: 797 PRVKSRGGRGQKAAAGGKKPLRR 819
+ + R G +++ +K RR
Sbjct: 748 QKDRRRSGAASSSSSSREKGSRR 770
>gi|239754599 PREDICTED: hypothetical protein [Homo sapiens]
Length = 294
Score = 82.0 bits (201), Expect = 2e-15
Identities = 68/183 (37%), Positives = 86/183 (46%), Gaps = 39/183 (21%)
Query: 173 KPQKAAAAGAKS----RSGKKPRRRGAKSRGDEDKKGRQREAKSRFG------KTRGGRR 222
+P +A AA A S R GK+P R + + + Q +++ G ++RGG
Sbjct: 83 RPMQATAAEAGSPGLGRLGKEPPSRESWTGSAPRRCPCQDASRAGSGVCRSRPQSRGGGS 142
Query: 223 KKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAA 282
+K RR K AA AKS GGGKKP++Q+ AA G K+ +SR GG KK RR GQ A
Sbjct: 143 RKPRRQKAAAAQAKSLGGGGKKPRRQKC----AAAGQKAAAEESRRGGGKKPRRGGQKAV 198
Query: 283 LAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKR 342
AGAK+ A A G K PRRR QKA KAA G K
Sbjct: 199 GAGAKKPQKAAAA-------------------------GTKTPRRRRQKAAKAAVWGQKA 233
Query: 343 GGG 345
G
Sbjct: 234 AAG 236
Score = 79.3 bits (194), Expect = 1e-14
Identities = 64/176 (36%), Positives = 79/176 (44%), Gaps = 29/176 (16%)
Query: 315 NPRWGRGGKKPRRR----GQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRG-KKPR 369
+P GR GK+P R G + R G G +SR + R G +KPR
Sbjct: 94 SPGLGRLGKEPPSRESWTGSAPRRCPCQDASRAGSGV-------CRSRPQSRGGGSRKPR 146
Query: 370 RQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRR 429
RQKA+AA AKS GGG KK PR Q QKA A + R GG KKPRR
Sbjct: 147 RQKAAAAQAKSLGGGGKK--------------PRRQKCAAAGQKAAAEESRRGGGKKPRR 192
Query: 430 RGPK---AAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAA 482
G K A + K+ + G K PRRR QKA + A + G+ AS +
Sbjct: 193 GGQKAVGAGAKKPQKAAAAGTKTPRRRRQKAAKAAVWGQKAAAGESLTPNSLASVS 248
Score = 76.6 bits (187), Expect = 8e-14
Identities = 66/183 (36%), Positives = 89/183 (48%), Gaps = 33/183 (18%)
Query: 367 KPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKP--RGGGS 424
+P + A+ AG+ G K+ G ++ Q+ R ++P RGGGS
Sbjct: 83 RPMQATAAEAGSPGLGRLGKEPPSRESWTGSAPRRCPCQDASRAGSGVCRSRPQSRGGGS 142
Query: 425 KKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGT 484
+KPRR+ AA++ KS GGGKKPR RQK A AG QKA+A +
Sbjct: 143 RKPRRQKAAAAQA---KSLGGGGKKPR------RQKCAAAG-----------QKAAAEES 182
Query: 485 KSRGGGLKSHSGKNLWRRGQKAEAAG----EKATAAGAKSRGRKQPRRQKPAVAGAKSRV 540
+ RGGG K G GQKA AG +KA AAG K+ R++ + K AV G K+
Sbjct: 183 R-RGGGKKPRRG------GQKAVGAGAKKPQKAAAAGTKTPRRRRQKAAKAAVWGQKAAA 235
Query: 541 GGS 543
G S
Sbjct: 236 GES 238
Score = 74.3 bits (181), Expect = 4e-13
Identities = 82/244 (33%), Positives = 107/244 (43%), Gaps = 23/244 (9%)
Query: 67 GGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRR 126
G + +RG + G E H A A N E +A + GRG
Sbjct: 3 GPDQMEIRGGPYLLLG-EVVGHSALGAQPAQAANGDADELLELSALLQPRAGRGPCATLS 61
Query: 127 GQ---KAAATGSKKPRWRAQ------KSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKA 177
G+ A A R RAQ +A AGS G ++ + +S G P++
Sbjct: 62 GRCITPATALLLLSHRLRAQCRPMQATAAEAGSPGLGRLGKEPPSR---ESWTGSAPRRC 118
Query: 178 AAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAK- 236
A SR+G R +SRG +K R+++A + K+ GG KK RR K AA G K
Sbjct: 119 PCQDA-SRAGSGVCRSRPQSRGGGSRKPRRQKAAAAQAKSLGGGGKKPRRQKCAAAGQKA 177
Query: 237 ----SRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAA 292
SRRGGGKKP RR GQKA G + K+ G K RR+ Q AA A + AA
Sbjct: 178 AAEESRRGGGKKP---RRGGQKAVGAGAKKPQKAAAAGTKTPRRRRQKAAKAAVWGQKAA 234
Query: 293 TAGE 296
AGE
Sbjct: 235 -AGE 237
Score = 71.6 bits (174), Expect = 3e-12
Identities = 69/193 (35%), Positives = 92/193 (47%), Gaps = 17/193 (8%)
Query: 5 GHRQCNQAAGRAGPGAPLGAALARTPVELAAESAAPALSAAAAGVKILGSGDKKLRRQKA 64
G C +GR A AL L A+ +AA AG LG K+ +++
Sbjct: 53 GRGPCATLSGRCITPA---TALLLLSHRLRAQCRPMQATAAEAGSPGLGRLGKEPPSRES 109
Query: 65 AAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPR 124
G R Q + AG + ++ G G + R QKAAAA KSLGG G+KPR
Sbjct: 110 WTGSAPRRCPCQDASRAGSGVCRSRPQSRGGGSRKPR---RQKAAAAQAKSLGGGGKKPR 166
Query: 125 RR-----GQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQK--AAAAAGVKS--QGGEKPQ 175
R+ GQKAAA S+ R +K G K GAGA+K AAAAG K+ + +K
Sbjct: 167 RQKCAAAGQKAAAEESR--RGGGKKPRRGGQKAVGAGAKKPQKAAAAGTKTPRRRRQKAA 224
Query: 176 KAAAAGAKSRSGK 188
KAA G K+ +G+
Sbjct: 225 KAAVWGQKAAAGE 237
Score = 70.9 bits (172), Expect = 5e-12
Identities = 69/173 (39%), Positives = 83/173 (47%), Gaps = 22/173 (12%)
Query: 505 KAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGN 564
+A+ +ATAA A S G + ++ P+ + GS R+ A+ A S
Sbjct: 79 RAQCRPMQATAAEAGSPGLGRLGKEPPS----RESWTGSAPRRCPCQDASRAGSGVCRSR 134
Query: 565 KQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTK-----SRSGDGGKKAWR- 618
QSRGGG KPR+ AA AK+ GGG K+P QK AA K SR G GGKK R
Sbjct: 135 PQSRGGGSRKPRRQKAAAAQAKSLGGGGKKPRRQKCAAAGQKAAAEESRRG-GGKKPRRG 193
Query: 619 -QKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAG 670
QKA G GA KKP QK AAA K T R K W + AAAG
Sbjct: 194 GQKAVGAGA---KKP----QKAAAAGTK---TPRRRRQKAAKAAVWGQKAAAG 236
Score = 68.9 bits (167), Expect = 2e-11
Identities = 51/108 (47%), Positives = 60/108 (55%), Gaps = 24/108 (22%)
Query: 722 KSRGGGGAKSR----GSGGAKSRGSGGAKSR------SGKKAAASKSHGGGGAKRRRGGG 771
+SRGGG K R + AKS G GG K R +G+KAAA +S GGG K RRGG
Sbjct: 136 QSRGGGSRKPRRQKAAAAQAKSLGGGGKKPRRQKCAAAGQKAAAEESRRGGGKKPRRGG- 194
Query: 772 AKSRSGEKAVTAGG---QKAAAAGGKKPPRVKSRGGR----GQKAAAG 812
+KAV AG QKAAAAG K P R + + + GQKAAAG
Sbjct: 195 ------QKAVGAGAKKPQKAAAAGTKTPRRRRQKAAKAAVWGQKAAAG 236
Score = 65.5 bits (158), Expect = 2e-10
Identities = 61/189 (32%), Positives = 84/189 (44%), Gaps = 25/189 (13%)
Query: 1 MDYRGHRQCN-QAAGRAGPGAPLGAALARTPVEL-----AAESAAPALSAAAAGVKIL-- 52
+ +R QC A A G+P L + P +A P A+ AG +
Sbjct: 74 LSHRLRAQCRPMQATAAEAGSPGLGRLGKEPPSRESWTGSAPRRCPCQDASRAGSGVCRS 133
Query: 53 -----GSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAG--AGGAENRGGGE 105
G G +K RRQKAAA K+ G GK+ R+ AAG A E+R GG
Sbjct: 134 RPQSRGGGSRKPRRQKAAAAQAKSLGGG------GKKPRRQKCAAAGQKAAAEESRRGGG 187
Query: 106 QKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAG 165
+K G K++G +KP QKAAA G+K PR R QK+A A + A A ++
Sbjct: 188 KKPRRGGQKAVGAGAKKP----QKAAAAGTKTPRRRRQKAAKAAVWGQKAAAGESLTPNS 243
Query: 166 VKSQGGEKP 174
+ S +P
Sbjct: 244 LASVSFSRP 252
Score = 60.8 bits (146), Expect = 5e-09
Identities = 60/182 (32%), Positives = 78/182 (42%), Gaps = 22/182 (12%)
Query: 408 RRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAE 467
R RAQ P R K SR + S + P + +A + +
Sbjct: 77 RLRAQCRPMQATAAEAGSPGLGRLGKEPPSRESWTGSAPRRCPCQDASRAGSGVCRSRPQ 136
Query: 468 SRG--DKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQ 525
SRG +K RQKA+AA KS GGG K R QK AAG+KA A ++ G K+
Sbjct: 137 SRGGGSRKPRRQKAAAAQAKSLGGGGKKP-------RRQKCAAAGQKAAAEESRRGGGKK 189
Query: 526 PRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAA 585
PRR G K+ G+K QKA AAG + + R K WGQ AAA
Sbjct: 190 PRR-----GGQKAVGAGAKKP--QKAAAAGTKT------PRRRRQKAAKAAVWGQKAAAG 236
Query: 586 KT 587
++
Sbjct: 237 ES 238
Score = 55.1 bits (131), Expect = 3e-07
Identities = 57/152 (37%), Positives = 66/152 (43%), Gaps = 33/152 (21%)
Query: 691 RRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAK-------SRGSGGA-----K 738
R RA+ R A G R GK+P +S G + SR G +
Sbjct: 77 RLRAQCRPMQATAAEAGSPGLGRLGKEPPSRESWTGSAPRRCPCQDASRAGSGVCRSRPQ 136
Query: 739 SRGSGGAKSRSGKKAAA-SKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAA-----AG 792
SRG G K R K AAA +KS GGGG K RR + A GQKAAA G
Sbjct: 137 SRGGGSRKPRRQKAAAAQAKSLGGGGKKPRR----------QKCAAAGQKAAAEESRRGG 186
Query: 793 GKKPPR-----VKSRGGRGQKAAAGGKKPLRR 819
GKKP R V + + QKAAA G K RR
Sbjct: 187 GKKPRRGGQKAVGAGAKKPQKAAAAGTKTPRR 218
Score = 53.1 bits (126), Expect = 1e-06
Identities = 55/141 (39%), Positives = 65/141 (46%), Gaps = 39/141 (27%)
Query: 477 QKASAAGT-------KSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQ 529
Q AS AG+ +SRGGG + R QKA AA K+ G K +PRRQ
Sbjct: 121 QDASRAGSGVCRSRPQSRGGGSRKP-------RRQKAAAAQAKSLGGGGK-----KPRRQ 168
Query: 530 KPAVAGAK-----SRVGGSKSRQR--QKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTA 582
K A AG K SR GG K +R QKAV AGA +++ G PR+ Q A
Sbjct: 169 KCAAAGQKAAAEESRRGGGKKPRRGGQKAVGAGAKK-----PQKAAAAGTKTPRRRRQKA 223
Query: 583 AAAKTRGGGDKQPGWQKAAAG 603
A A G QKAAAG
Sbjct: 224 AKAAVWG--------QKAAAG 236
Score = 49.7 bits (117), Expect = 1e-05
Identities = 46/122 (37%), Positives = 54/122 (44%), Gaps = 39/122 (31%)
Query: 265 KSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKK 324
+SRGGG +K RRQ AA AK GG GGKK
Sbjct: 136 QSRGGGSRKPRRQKAAAA----------------QAKSLGG---------------GGKK 164
Query: 325 PRRRGQKAT--KAAAAGTKRGGG-----GQQKAAVVGVKSRKKQRRRG-KKPRRQKASAA 376
PRR+ A KAAA ++RGGG G QKA G K +K G K PRR++ AA
Sbjct: 165 PRRQKCAAAGQKAAAEESRRGGGKKPRRGGQKAVGAGAKKPQKAAAAGTKTPRRRRQKAA 224
Query: 377 GA 378
A
Sbjct: 225 KA 226
>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
Length = 494
Score = 80.5 bits (197), Expect = 6e-15
Identities = 81/363 (22%), Positives = 147/363 (40%), Gaps = 28/363 (7%)
Query: 204 KGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRV 263
KGR+ E F +R + G K R K ++RR ++ + +SR
Sbjct: 137 KGRKNEGVIEFVSYSDMKRALEKLDGTEVNGRKIRLVEDKPGSRRRRSYSRSRSHSRSR- 195
Query: 264 GKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGK 323
SR +K R + ++ + +K R + +G + +K R +S + +
Sbjct: 196 --SRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKE 253
Query: 324 KPRRRGQKATKAAAAGTKRGGGGQQKAAVVGV---------KSRKKQRRRGKKPRRQKAS 374
K R R A K+ + + Q VG KS+ K R R ++ RR +
Sbjct: 254 KSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQE-RRVEEE 312
Query: 375 AAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKA 434
G+ SRG +K LR+++ R + R R++ +K + G K+ R
Sbjct: 313 KRGSVSRGRSQEKSLRQSRSRSRSK-----GGSRSRSRSRSKSKDKRKGRKRSREESRSR 367
Query: 435 AKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSH 494
++SR RS R+RG K KA + + + D + + ++ + KS
Sbjct: 368 SRSRSKSERS------RKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSE 421
Query: 495 SGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAA 554
S + RG+ A + T + ++S + +P + + +KS SK+R R K+ +
Sbjct: 422 SSQR-EGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSKS---ASKTRSRSKSRSR 477
Query: 555 GAT 557
A+
Sbjct: 478 SAS 480
Score = 73.2 bits (178), Expect = 9e-13
Identities = 88/377 (23%), Positives = 152/377 (40%), Gaps = 52/377 (13%)
Query: 120 GRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAA 179
GRK R K GS++ R ++ + + S++R ++K+ + +G K + +
Sbjct: 167 GRKIRLVEDKP---GSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSR 223
Query: 180 AGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRR 239
+G++SRS KSR + R ++ KSR ++K R +AG ++S+
Sbjct: 224 SGSRSRS---------KSRSRSQSRSRSKKEKSR-----SPSKEKSRSRSHSAGKSRSK- 268
Query: 240 GGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPA 299
K Q + + G SR K R + Q +RR EK
Sbjct: 269 ---SKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQ-------ERR---VEEEKRG 315
Query: 300 AKGRGGRGPKSLGGQNPR-WGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSR 358
+ RG KSL R +GG + R R + +K G KR +SR
Sbjct: 316 SVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRS----------REESR 365
Query: 359 KKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAK 418
+ R R K R +K + S+ G KK +E R R R + R K+ +++
Sbjct: 366 SRSRSRSKSERSRKRGSK-RDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQ 424
Query: 419 PRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQK 478
G G + A ++ +SRS K + + +++ +++R K +
Sbjct: 425 REGRGESE------NAGTNQETRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRS 478
Query: 479 ASAAGTKSRGGGLKSHS 495
AS + ++SR +SHS
Sbjct: 479 ASRSPSRSRS---RSHS 492
Score = 67.4 bits (163), Expect = 5e-11
Identities = 68/350 (19%), Positives = 135/350 (38%), Gaps = 44/350 (12%)
Query: 99 ENRGGGEQKAAAAGTKSLG-GRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGA 157
E++ G ++ + + ++S R R R ++ + SK +++ + +GS++R
Sbjct: 174 EDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSR 233
Query: 158 QKAAAAAGVKSQGGEKPQKAAA-----AGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKS 212
++ + + K + P K + + KSRS K + D K + R
Sbjct: 234 SRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSR 293
Query: 213 RFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDK 272
K++ R + RR + G+ SR +K +Q R ++ G +SR SR
Sbjct: 294 HKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSR---SRSRSKS 350
Query: 273 KLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKA 332
K +R+G+ + ++ R + + ++ R+RG K
Sbjct: 351 KDKRKGRKRSREESRSRSRSRS--------------------------KSERSRKRGSKR 384
Query: 333 TKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREA 392
A + K+ +K +SR R K+ K+ ++ + RG + G +
Sbjct: 385 DSKAGSSKKK-----KKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQE 439
Query: 393 KR---RGDGRKKPRW-QNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSR 438
R R + + KP R R++ A + R + R P ++SR
Sbjct: 440 TRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRSR 489
Score = 64.7 bits (156), Expect = 3e-10
Identities = 68/324 (20%), Positives = 130/324 (40%), Gaps = 37/324 (11%)
Query: 324 KPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGG 383
+ R R + +++ + +K + + G +SR K R R + R K KSR
Sbjct: 195 RSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKE----KSRSP 250
Query: 384 GDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSR 443
+K + G R K + Q + KP+ S+ P R KS+
Sbjct: 251 SKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPK---SRSPSRH----------KSK 297
Query: 444 SGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRG 503
S K R R Q+ R + + G+ SRG ++ + S + ++S+GG ++ R
Sbjct: 298 S----KSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGS----RSRSRSRSK 349
Query: 504 QKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAK--SRVGGSKSRQRQKAVAAGATSHGG 561
K + G K + ++SR R + + ++ G+K S+ G SK ++++ + + S
Sbjct: 350 SKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSR 409
Query: 562 GGNKQ---------SRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDG 612
+K+ R G G +++R +P + +KS S
Sbjct: 410 SVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSKSASKTR 469
Query: 613 GKKAWRQKAAG-TGAKSRKKPWRR 635
+ R ++A + ++SR + R
Sbjct: 470 SRSKSRSRSASRSPSRSRSRSHSR 493
Score = 63.9 bits (154), Expect = 6e-10
Identities = 89/380 (23%), Positives = 151/380 (39%), Gaps = 59/380 (15%)
Query: 377 GAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSK----KPRRRGP 432
G K R DK G R + R R ++ R ++K+ + R G SK K R R
Sbjct: 167 GRKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKS---RSRSGSSKSSHSKSRSRSR 223
Query: 433 KAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLK 492
++SR KSRS + R + +K+R + K++ R ++ +AG KSR K
Sbjct: 224 SGSRSRS-KSRSRSQSRSRSKKEKSRSPS----------KEKSRSRSHSAG-KSRSKS-K 270
Query: 493 SHSGKNLWRRGQ--KAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQK 550
+ + + K ++ + +KSR R Q RR + G+ SR + RQ
Sbjct: 271 DQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQS 330
Query: 551 AVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSG 610
+SR GG++ R ++ + K +G +K + ++SRS
Sbjct: 331 -------------RSRSRSKGGSRSRSRSRSKSKDKRKG--------RKRSREESRSRSR 369
Query: 611 DGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAG 670
K +SRK+ +R K ++ +K S+ + ++ A
Sbjct: 370 SRSKSE----------RSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAK 419
Query: 671 SESSAAAAVGQEAEA-RKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGA 729
SESS G+ A + R R++S N P + R + K+R +
Sbjct: 420 SESSQREGRGESENAGTNQETRSRSRSNSKSKPNL-----PSESRSRSKSASKTRSRSKS 474
Query: 730 KSRGSGGAKSRGSGGAKSRS 749
+SR + + SR + SRS
Sbjct: 475 RSRSASRSPSRSRSRSHSRS 494
Score = 61.6 bits (148), Expect = 3e-09
Identities = 78/351 (22%), Positives = 152/351 (43%), Gaps = 31/351 (8%)
Query: 352 VVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRA 411
V G K R + + G + RR+ S + + SR + R+++ R G K R R+
Sbjct: 165 VNGRKIRLVEDKPGSR-RRRSYSRSRSHSRSRSRSRHSRKSRSR-SGSSKSSHSKSRSRS 222
Query: 412 QKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGD 471
+ ++ K R R ++S+ KSRS +K R R A ++ ++S+
Sbjct: 223 RSGSRSR------SKSRSRSQSRSRSKKEKSRSPSKEKSRSRS----HSAGKSRSKSKDQ 272
Query: 472 KKQGRQKASAAGTKSRGGGLKSHSGKNLWR-RGQKAEAAGEKATAAGAKSRGRKQPRRQK 530
++ Q G K + H K+ R R Q+ EK G+ SRGR Q + +
Sbjct: 273 AEEKIQNNDNVG-KPKSRSPSRHKSKSKSRSRSQERRVEEEK---RGSVSRGRSQEKSLR 328
Query: 531 PAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGG 590
+ + ++S+ GGS+SR R ++ + G K+SR ++ R ++ + K
Sbjct: 329 QSRSRSRSK-GGSRSRSRSRSKSKDKRK----GRKRSREESRSRSRSRSKSERSRKRGSK 383
Query: 591 GDKQPG--WQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWA 648
D + G +K +S+S + +++ S+++ RG+ + A +
Sbjct: 384 RDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQRE--GRGESENAGTNQ--E 439
Query: 649 TGATSRGSGGKQPRWQKPAAAGSESSA---AAAVGQEAEARKKPRRRRAKS 696
T + SR + +P + + S+S++ + + + A + P R R++S
Sbjct: 440 TRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRSRS 490
Score = 61.6 bits (148), Expect = 3e-09
Identities = 70/343 (20%), Positives = 146/343 (42%), Gaps = 48/343 (13%)
Query: 57 KKLRRQKAAAGGKKARLRGQKGAVAGKEAR-QHWQKAAGAGGAENRGGGEQKAAAAGTKS 115
+K+R + G ++ R + + + +R +H +K+ G+ + ++ +
Sbjct: 168 RKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRS--- 224
Query: 116 LGGRGR-KPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGE-- 172
G R R K R R Q + + +K R +++ + + S + G K+ A K Q +
Sbjct: 225 -GSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNV 283
Query: 173 -KPQKAAAAGAKSRSGKKPR---------RRGAKSRG-DEDKKGRQREAKSRFGKTRGGR 221
KP+ + + KS+S + R +RG+ SRG ++K RQ ++SR ++GG
Sbjct: 284 GKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSR---SKGGS 340
Query: 222 RKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSR---------GGGDK 272
R + R ++S+ +K +K+ R ++ + +S+ +SR G K
Sbjct: 341 RSRSR--------SRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSK 392
Query: 273 KLRRQGQNAALAGAKRRGAATAGE--KPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQ 330
K +++ + + + + R + E K + R GRG G N ++ R R +
Sbjct: 393 KKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTN-------QETRSRSR 445
Query: 331 KATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKA 373
+K+ + A+ +S+ + R + P R ++
Sbjct: 446 SNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRS 488
Score = 53.5 bits (127), Expect = 8e-07
Identities = 53/264 (20%), Positives = 109/264 (41%), Gaps = 20/264 (7%)
Query: 567 SRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGA 626
SR ++ R + + +++R G K + ++SRSG + R ++ +
Sbjct: 186 SRSRSHSRSRSRSRHSRKSRSRSGSSKS----SHSKSRSRSRSGSRSRSKSRSRSQSR-S 240
Query: 627 KSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEAR 686
+S+K+ R K+ + + A + S+ + + Q G S + + +++
Sbjct: 241 RSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPS---RHKSK 297
Query: 687 KKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKS------- 739
K R R + R + + +V Q + + +SR GG++SR +KS
Sbjct: 298 SKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGR 357
Query: 740 -RGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPR 798
R ++SRS ++ + +S G + + G +K + E + + + + K+
Sbjct: 358 KRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREH 417
Query: 799 VKS----RGGRGQKAAAGGKKPLR 818
KS R GRG+ AG + R
Sbjct: 418 AKSESSQREGRGESENAGTNQETR 441
Score = 52.4 bits (124), Expect = 2e-06
Identities = 63/334 (18%), Positives = 132/334 (39%), Gaps = 33/334 (9%)
Query: 476 RQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAG 535
R+ S + + SR HS K+ R G + + + + + SR R + R + + +
Sbjct: 182 RRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSR 241
Query: 536 AKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQP 595
+K S S+++ ++ SH G ++ + Q K+R P
Sbjct: 242 SKKEKSRSPSKEKSRS-----RSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRS-----P 291
Query: 596 GWQKAAAGVTKSRSGDGGKKAWRQKAAGTG-AKSRKKPWRRGQKDAAAAEKAWATGATSR 654
K+ + KSRS ++ +K +S++K R+ + + SR
Sbjct: 292 SRHKSKS---KSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSR-------------SRSR 335
Query: 655 GSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRR 714
GG + R + + + + +E+ +R + R + +SR G + + + +++
Sbjct: 336 SKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKK 395
Query: 715 GKKPRLGKSRGGGGAKSRGSGGAKSR-----GSGGAKSRSGKKAAASKSHGGGGAKRRRG 769
+ +SR + S+ AKS G G +++ + S+S +K
Sbjct: 396 KEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLP 455
Query: 770 GGAKSRSGEKAVTAGGQKA-AAAGGKKPPRVKSR 802
++SRS + T K+ + + + P R +SR
Sbjct: 456 SESRSRSKSASKTRSRSKSRSRSASRSPSRSRSR 489
Score = 35.8 bits (81), Expect = 0.17
Identities = 36/154 (23%), Positives = 59/154 (38%), Gaps = 21/154 (13%)
Query: 680 GQEAEARK------KP--RRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGG--- 728
G E RK KP RRRR+ SR + + R + R +SR G
Sbjct: 162 GTEVNGRKIRLVEDKPGSRRRRSYSRSRSHSRS-------RSRSRHSRKSRSRSGSSKSS 214
Query: 729 ---AKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGG 785
++SR G++SR ++S+S ++ KS K R + +S K+
Sbjct: 215 HSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAE 274
Query: 786 QKAAAAGGKKPPRVKSRGGRGQKAAAGGKKPLRR 819
+K P+ +S K+ + + RR
Sbjct: 275 EKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERR 308
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 77.0 bits (188), Expect = 6e-14
Identities = 174/825 (21%), Positives = 288/825 (34%), Gaps = 100/825 (12%)
Query: 32 ELAAESAAPALSAAA------AGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEA 85
E E + PA AAA AG S D + GK + Q A +
Sbjct: 172 ETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTK 231
Query: 86 RQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKS 145
+KAA A G + G G R +KP + ++ GS+ +++
Sbjct: 232 ESPARKAAPAPG---KVGDVTPQVKGGALPPAKRAKKPEEESE-SSEEGSE-----SEEE 282
Query: 146 AAAGSKNRGAGAQKA----AAAAGVKSQGGE-----KPQKAAAAGAKSRSGKKPRRRGAK 196
A AG++++ ++K AA+A K G+ P KA A +++++GK +
Sbjct: 283 APAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESS 342
Query: 197 SRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQR-RRGQKA 255
S D + AK+ + A G S+ G P K+ R+G
Sbjct: 343 SEESSDSEEETPAAKALL--------------QAKASGKTSQVGAASAPAKESPRKGAAP 388
Query: 256 ATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQN 315
A GK+ ++ K R + ++ + A A KP+ K R + ++
Sbjct: 389 APPGKTGPAVAKAQAGK--REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKES 446
Query: 316 PRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAA-----VVGVKSRKKQRRRGKKPRR 370
PR G PR+ G A + + + + + + + + GK P+
Sbjct: 447 PRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQV 506
Query: 371 QKASAAGAKSRGGGDKKGLREAKRRGDGRKKP-----RWQNPRRRAQKAPAAKPRGGGSK 425
+ AS G G KG G P +W+ + + + G +
Sbjct: 507 KPASTMGMGPLG----KGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDG---E 559
Query: 426 KPRRRGPKAAKSRG----GKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKAS- 480
P P KS G K S K P QKA A + AE D + +++S
Sbjct: 560 VPTAVAPAQEKSLGNILQAKPTSSPAKGP---PQKAGPVAVQVKAEKPMDNSESSEESSD 616
Query: 481 AAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRV 540
+A ++ + + K + Q + T A AK + Q P AG +
Sbjct: 617 SADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV-APVRVGTQAPRKAGTATSP 675
Query: 541 GGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKA 600
GS AVA G + + T AK+ G G + KA
Sbjct: 676 AGS-----SPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQ----VKA 726
Query: 601 AAGVTKSRSGDGGKKAWRQKAAG--TGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGG 658
A+ K G G K T K+ K+ ++ + +E+A A+ A + S
Sbjct: 727 ASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVK 786
Query: 659 KQPRWQKPAAA------------GSESSAAAAVGQEAEARKKPRRRRAK-----SRGDG- 700
K PAAA G +AAA Q + ++ KP R + +RG
Sbjct: 787 KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 846
Query: 701 --GQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKS 758
AV + G + G S ++ A+ + SG A A +S
Sbjct: 847 VPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKES 906
Query: 759 HGGGGAKRRRG--GGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKS 801
G A G G + +++G++ + + + + G+ P V S
Sbjct: 907 PRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTS 951
Score = 70.5 bits (171), Expect = 6e-12
Identities = 176/855 (20%), Positives = 295/855 (34%), Gaps = 115/855 (13%)
Query: 20 APLGAALARTPVELAAESAAPALSAAAAGVKIL------------GSGDKKLRRQKAAAG 67
A + AA A+ +++ A P + A K+ G+ A AG
Sbjct: 625 AAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAG 684
Query: 68 GKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQ-KAAAAGTKSLGGRGRKPRRR 126
G + + + A G A++ G G Q KAA+ K G+G P
Sbjct: 685 GTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLP 744
Query: 127 GQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAA-AGVKSQGGEKPQKAAAAGAKSR 185
G+ TG + +A+K + S + +++AAA+ A VK+ + KA A A++
Sbjct: 745 GK----TGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAP 800
Query: 186 SGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKP 245
S K G G+ A ++ +++ + KP ++ + P
Sbjct: 801 SAK----------GTISAPGKVVTAAAQ------AKQRSPSKVKPPVRNPQNSTVLARGP 844
Query: 246 QKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGG 305
G+ AT +++ G G + + A A KP+ K
Sbjct: 845 ASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA--------ETLAQVKPSGKTHQI 896
Query: 306 RGPKSLGGQNPRWGRGGKKPRRRGQKATKAA------AAGTKRGGGGQQKAAVV------ 353
R + ++PR G P + G A +A ++ + G+ AAV
Sbjct: 897 RAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIK 956
Query: 354 -------------GVKSRKKQRRRGKKPRRQKASAAGAKSRGGG--DKKGLREAKRRGDG 398
G + Q + PR+ +AS + A+S D+ + + G
Sbjct: 957 PPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPG 1016
Query: 399 RKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSR--SGGGKKPRRRGQK 456
+ P + AP A G S K R K G ++ S G P Q
Sbjct: 1017 IRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQS 1076
Query: 457 ARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAA 516
+A + R K Q+A+ A S S S G+ + A T
Sbjct: 1077 TSVQAKGTN-KLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLV 1135
Query: 517 GAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPR 576
G + R + ++ A ++ V + G T +K +
Sbjct: 1136 GP-TPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATP-------- 1186
Query: 577 QWGQTAAAAKTRGGGDKQPGWQKA----AAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKP 632
+ + + + T D G Q+A AAG+ ++G GK+A A+GT + +KP
Sbjct: 1187 KLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTG--GKEA----ASGTTPQKSRKP 1240
Query: 633 WRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAE-------- 684
++G + A+ A + T G P + A + QE +
Sbjct: 1241 -KKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKE 1299
Query: 685 -ARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSG 743
+RK R+ K GD Q AA R KK +LG GG + S S+G
Sbjct: 1300 SSRKGWESRKRKLSGD--QPAA----RTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKA 1353
Query: 744 GAKSRSG--KKAAASKSHGGGGAK------RRRGGGAKSRSGEKAVTAGGQKAAAAGGKK 795
SG K+ S G GAK ++G G + + +K + KK
Sbjct: 1354 KRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKK 1413
Query: 796 PPRVKSRGGRGQKAA 810
K + + +KA+
Sbjct: 1414 DKEKKEKKKKAKKAS 1428
Score = 45.8 bits (107), Expect = 2e-04
Identities = 55/242 (22%), Positives = 92/242 (38%), Gaps = 20/242 (8%)
Query: 32 ELAAESAAPALSAAAAGVKIL-GSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQ 90
E + AA LS G + G+ +K R+ K AG +A + + Q W
Sbjct: 1209 EAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWP 1268
Query: 91 ------KAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQK 144
+A+ E+K TK +G + R+R ++ PR + +K
Sbjct: 1269 LNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKK 1328
Query: 145 SAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKK 204
AG G A + S+G K KA+ + + +GAK +E+ +
Sbjct: 1329 KLGAGE---GGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQ 1385
Query: 205 --------GRQREAKSRFGKTRGGRRKKHRRPKPAAGGAK--SRRGGGKKPQKQRRRGQK 254
G Q KS+ K + +RKK + K AK S + QK++++ +K
Sbjct: 1386 KGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKK 1445
Query: 255 AA 256
A
Sbjct: 1446 TA 1447
Score = 41.6 bits (96), Expect = 0.003
Identities = 102/454 (22%), Positives = 164/454 (36%), Gaps = 70/454 (15%)
Query: 34 AAESAAPALSAAAAGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAA 93
+A PA S + V+ G KLR+ K Q+ A + + +
Sbjct: 1064 SAVGTLPATSPQSTSVQ--AKGTNKLRKPKLP--------EVQQATKAPESSDDSEDSSD 1113
Query: 94 GAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNR 153
+ G+E G G Q A +A T +G + ++ AA S+ +S +G
Sbjct: 1114 SSSGSEEDGEGPQGAKSAHTL-VGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTP 1172
Query: 154 G---AGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREA 210
G A +Q + A + S P ++ AK K + ++ G K +EA
Sbjct: 1173 GLTPANSQASKATPKLDSS----PSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEA 1228
Query: 211 KSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGG 270
S G +K R+PK AG ++ + Q GQ +++V S
Sbjct: 1229 AS------GTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLN-EAQVQASVVKV 1281
Query: 271 DKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQ 330
+L Q +R+ ++ + KG R K L G P + PR + +
Sbjct: 1282 LTELLEQ---------ERKKVVDTTKESSRKGWESRKRK-LSGDQP----AARTPRSKKK 1327
Query: 331 KATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLR 390
K A G GG+ V K K +R KAS GD K
Sbjct: 1328 KKLGA-------GEGGE-----ASVSPEKTSTTSKGKAKRDKAS---------GDVK--- 1363
Query: 391 EAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKP 450
E K +G + P QK G S PK+ K + + K+
Sbjct: 1364 EKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSN------PKSKKEKKKSDKRKKDKEK 1417
Query: 451 RRRGQKARQKAAEAGAESRGDKKQGRQKASAAGT 484
+ + +KA+ KA+ +ES KK+ ++K +A T
Sbjct: 1418 KEKKKKAK-KASTKDSESPSQKKKKKKKKTAEQT 1450
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 77.0 bits (188), Expect = 6e-14
Identities = 174/825 (21%), Positives = 288/825 (34%), Gaps = 100/825 (12%)
Query: 32 ELAAESAAPALSAAA------AGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEA 85
E E + PA AAA AG S D + GK + Q A +
Sbjct: 172 ETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTK 231
Query: 86 RQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKS 145
+KAA A G + G G R +KP + ++ GS+ +++
Sbjct: 232 ESPARKAAPAPG---KVGDVTPQVKGGALPPAKRAKKPEEESE-SSEEGSE-----SEEE 282
Query: 146 AAAGSKNRGAGAQKA----AAAAGVKSQGGE-----KPQKAAAAGAKSRSGKKPRRRGAK 196
A AG++++ ++K AA+A K G+ P KA A +++++GK +
Sbjct: 283 APAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESS 342
Query: 197 SRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQR-RRGQKA 255
S D + AK+ + A G S+ G P K+ R+G
Sbjct: 343 SEESSDSEEETPAAKALL--------------QAKASGKTSQVGAASAPAKESPRKGAAP 388
Query: 256 ATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQN 315
A GK+ ++ K R + ++ + A A KP+ K R + ++
Sbjct: 389 APPGKTGPAVAKAQAGK--REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKES 446
Query: 316 PRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAA-----VVGVKSRKKQRRRGKKPRR 370
PR G PR+ G A + + + + + + + + GK P+
Sbjct: 447 PRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQV 506
Query: 371 QKASAAGAKSRGGGDKKGLREAKRRGDGRKKP-----RWQNPRRRAQKAPAAKPRGGGSK 425
+ AS G G KG G P +W+ + + + G +
Sbjct: 507 KPASTMGMGPLG----KGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDG---E 559
Query: 426 KPRRRGPKAAKSRG----GKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKAS- 480
P P KS G K S K P QKA A + AE D + +++S
Sbjct: 560 VPTAVAPAQEKSLGNILQAKPTSSPAKGP---PQKAGPVAVQVKAEKPMDNSESSEESSD 616
Query: 481 AAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRV 540
+A ++ + + K + Q + T A AK + Q P AG +
Sbjct: 617 SADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV-APVRVGTQAPRKAGTATSP 675
Query: 541 GGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKA 600
GS AVA G + + T AK+ G G + KA
Sbjct: 676 AGS-----SPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQ----VKA 726
Query: 601 AAGVTKSRSGDGGKKAWRQKAAG--TGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGG 658
A+ K G G K T K+ K+ ++ + +E+A A+ A + S
Sbjct: 727 ASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVK 786
Query: 659 KQPRWQKPAAA------------GSESSAAAAVGQEAEARKKPRRRRAK-----SRGDG- 700
K PAAA G +AAA Q + ++ KP R + +RG
Sbjct: 787 KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 846
Query: 701 --GQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKS 758
AV + G + G S ++ A+ + SG A A +S
Sbjct: 847 VPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKES 906
Query: 759 HGGGGAKRRRG--GGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKS 801
G A G G + +++G++ + + + + G+ P V S
Sbjct: 907 PRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTS 951
Score = 63.9 bits (154), Expect = 6e-10
Identities = 182/882 (20%), Positives = 300/882 (34%), Gaps = 132/882 (14%)
Query: 20 APLGAALARTPVELAAESAAPALSAAAAGVKIL------------GSGDKKLRRQKAAAG 67
A + AA A+ +++ A P + A K+ G+ A AG
Sbjct: 625 AAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAG 684
Query: 68 GKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQ-KAAAAGTKSLGGRGRKPRRR 126
G + + + A G A++ G G Q KAA+ K G+G P
Sbjct: 685 GTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLP 744
Query: 127 GQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAA-AGVKSQGGEKPQKAAAAGAKSR 185
G+ TG + +A+K + S + +++AAA+ A VK+ + KA A A++
Sbjct: 745 GK----TGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAP 800
Query: 186 SGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKP 245
S K G G+ A ++ +++ + KP ++ + P
Sbjct: 801 SAK----------GTISAPGKVVTAAAQ------AKQRSPSKVKPPVRNPQNSTVLARGP 844
Query: 246 QKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGG 305
G+ AT +++ G G + + A A KP+ K
Sbjct: 845 ASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA--------ETLAQVKPSGKTHQI 896
Query: 306 RGPKSLGGQNPRWGRGGKKPRRRGQKATKAA------AAGTKRGGGGQQKAAVV------ 353
R + ++PR G P + G A +A ++ + G+ AAV
Sbjct: 897 RAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIK 956
Query: 354 -------------GVKSRKKQRRRGKKPRRQKASAAGAKSRGGG--DKKGLREAKRRGDG 398
G + Q + PR+ +AS + A+S D+ + + G
Sbjct: 957 PPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPG 1016
Query: 399 RKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSR------------SGG 446
+ P + AP A G S K R K G ++
Sbjct: 1017 IRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAA 1076
Query: 447 GKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKA 506
K ++ +A+ A S D G A++ + S + K Q+A
Sbjct: 1077 LKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQA 1136
Query: 507 EAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSR--VGGSKSRQRQ--KAVAAGATSHGGG 562
A E + + S GAKS +G + SR + AA ++
Sbjct: 1137 TKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVV 1196
Query: 563 GNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQP-------------GWQKA----AAGVT 605
QS G P + A+K D P G Q+A AAG+
Sbjct: 1197 APSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGML 1256
Query: 606 KSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQK 665
++G GK+A A+GT + +KP ++G + A+ A + T G P +
Sbjct: 1257 SPKTG--GKEA----ASGTTPQKSRKP-KKGAGNPQASTLALQSNITQCLLGQPWPLNEA 1309
Query: 666 PAAAGSESSAAAAVGQEAE---------ARKKPRRRRAKSRGDGGQNAAVGINPWQRRGK 716
A + QE + +RK R+ K GD Q AA R K
Sbjct: 1310 QVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGD--QPAA----RTPRSKK 1363
Query: 717 KPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSG--KKAAASKSHGGGGAK------RRR 768
K +LG GG + S S+G SG K+ S G GAK ++
Sbjct: 1364 KKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQK 1423
Query: 769 GGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGRGQKAA 810
G G + + +K + KK K + + +KA+
Sbjct: 1424 GMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKAS 1465
Score = 45.8 bits (107), Expect = 2e-04
Identities = 105/463 (22%), Positives = 167/463 (36%), Gaps = 70/463 (15%)
Query: 26 LARTPVELAAESAAPALSAAAA-GVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKE 84
+ART +SA L A + + G KLR+ K Q+ A +
Sbjct: 1091 VARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLP--------EVQQATKAPES 1142
Query: 85 ARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQK 144
+ + + G+E G G Q A +A T LG + ++ AA S+ +
Sbjct: 1143 SDDSEDSSDSSSGSEEDGEGPQGAKSAHT--LGPTPSRTETLVEETAAESSEDDVVAPSQ 1200
Query: 145 SAAAGSKNRG---AGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDE 201
S +G G A +Q + A + S P ++ AK K + ++ G
Sbjct: 1201 SLLSGYMTPGLTPANSQASKATPKLDSS----PSVSSTLAAKDDPDGKQEAKPQQAAGML 1256
Query: 202 DKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKS 261
K +EA S G +K R+PK AG ++ + Q GQ ++
Sbjct: 1257 SPKTGGKEAAS------GTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLN-EA 1309
Query: 262 RVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRG 321
+V S +L Q +R+ ++ + KG R K L G P
Sbjct: 1310 QVQASVVKVLTELLEQ---------ERKKVVDTTKESSRKGWESRKRK-LSGDQP----A 1355
Query: 322 GKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSR 381
+ PR + +K A G GG+ V K K +R KAS
Sbjct: 1356 ARTPRSKKKKKLGA-------GEGGE-----ASVSPEKTSTTSKGKAKRDKAS------- 1396
Query: 382 GGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGK 441
GD K E K +G + P QK G S PK+ K +
Sbjct: 1397 --GDVK---EKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSN------PKSKKEKKKS 1445
Query: 442 SRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGT 484
+ K+ + + +KA+ KA+ +ES KK+ ++K +A T
Sbjct: 1446 DKRKKDKEKKEKKKKAK-KASTKDSESPSQKKKKKKKKTAEQT 1487
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 77.0 bits (188), Expect = 6e-14
Identities = 174/825 (21%), Positives = 288/825 (34%), Gaps = 100/825 (12%)
Query: 32 ELAAESAAPALSAAA------AGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEA 85
E E + PA AAA AG S D + GK + Q A +
Sbjct: 172 ETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTK 231
Query: 86 RQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKS 145
+KAA A G + G G R +KP + ++ GS+ +++
Sbjct: 232 ESPARKAAPAPG---KVGDVTPQVKGGALPPAKRAKKPEEESE-SSEEGSE-----SEEE 282
Query: 146 AAAGSKNRGAGAQKA----AAAAGVKSQGGE-----KPQKAAAAGAKSRSGKKPRRRGAK 196
A AG++++ ++K AA+A K G+ P KA A +++++GK +
Sbjct: 283 APAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESS 342
Query: 197 SRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQR-RRGQKA 255
S D + AK+ + A G S+ G P K+ R+G
Sbjct: 343 SEESSDSEEETPAAKALL--------------QAKASGKTSQVGAASAPAKESPRKGAAP 388
Query: 256 ATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQN 315
A GK+ ++ K R + ++ + A A KP+ K R + ++
Sbjct: 389 APPGKTGPAVAKAQAGK--REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKES 446
Query: 316 PRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAA-----VVGVKSRKKQRRRGKKPRR 370
PR G PR+ G A + + + + + + + + GK P+
Sbjct: 447 PRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQV 506
Query: 371 QKASAAGAKSRGGGDKKGLREAKRRGDGRKKP-----RWQNPRRRAQKAPAAKPRGGGSK 425
+ AS G G KG G P +W+ + + + G +
Sbjct: 507 KPASTMGMGPLG----KGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDG---E 559
Query: 426 KPRRRGPKAAKSRG----GKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKAS- 480
P P KS G K S K P QKA A + AE D + +++S
Sbjct: 560 VPTAVAPAQEKSLGNILQAKPTSSPAKGP---PQKAGPVAVQVKAEKPMDNSESSEESSD 616
Query: 481 AAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRV 540
+A ++ + + K + Q + T A AK + Q P AG +
Sbjct: 617 SADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV-APVRVGTQAPRKAGTATSP 675
Query: 541 GGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKA 600
GS AVA G + + T AK+ G G + KA
Sbjct: 676 AGS-----SPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQ----VKA 726
Query: 601 AAGVTKSRSGDGGKKAWRQKAAG--TGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGG 658
A+ K G G K T K+ K+ ++ + +E+A A+ A + S
Sbjct: 727 ASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVK 786
Query: 659 KQPRWQKPAAA------------GSESSAAAAVGQEAEARKKPRRRRAK-----SRGDG- 700
K PAAA G +AAA Q + ++ KP R + +RG
Sbjct: 787 KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 846
Query: 701 --GQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKS 758
AV + G + G S ++ A+ + SG A A +S
Sbjct: 847 VPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKES 906
Query: 759 HGGGGAKRRRG--GGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKS 801
G A G G + +++G++ + + + + G+ P V S
Sbjct: 907 PRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTS 951
Score = 68.9 bits (167), Expect = 2e-11
Identities = 176/855 (20%), Positives = 294/855 (34%), Gaps = 116/855 (13%)
Query: 20 APLGAALARTPVELAAESAAPALSAAAAGVKIL------------GSGDKKLRRQKAAAG 67
A + AA A+ +++ A P + A K+ G+ A AG
Sbjct: 625 AAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAG 684
Query: 68 GKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQ-KAAAAGTKSLGGRGRKPRRR 126
G + + + A G A++ G G Q KAA+ K G+G P
Sbjct: 685 GTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLP 744
Query: 127 GQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAA-AGVKSQGGEKPQKAAAAGAKSR 185
G+ TG + +A+K + S + +++AAA+ A VK+ + KA A A++
Sbjct: 745 GK----TGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAP 800
Query: 186 SGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKP 245
S K G G+ A ++ +++ + KP ++ + P
Sbjct: 801 SAK----------GTISAPGKVVTAAAQ------AKQRSPSKVKPPVRNPQNSTVLARGP 844
Query: 246 QKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGG 305
G+ AT +++ G G + + A A KP+ K
Sbjct: 845 ASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA--------ETLAQVKPSGKTHQI 896
Query: 306 RGPKSLGGQNPRWGRGGKKPRRRGQKATKAA------AAGTKRGGGGQQKAAVV------ 353
R + ++PR G P + G A +A ++ + G+ AAV
Sbjct: 897 RAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIK 956
Query: 354 -------------GVKSRKKQRRRGKKPRRQKASAAGAKSRGGG--DKKGLREAKRRGDG 398
G + Q + PR+ +AS + A+S D+ + + G
Sbjct: 957 PPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPG 1016
Query: 399 RKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSR--SGGGKKPRRRGQK 456
+ P + AP A G S K R K G ++ S G P Q
Sbjct: 1017 IRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQS 1076
Query: 457 ARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAA 516
+A + R K Q+A+ A S S S G+ + A T
Sbjct: 1077 TSVQAKGTN-KLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLG 1135
Query: 517 GAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPR 576
SR + ++ A ++ V + G T +K +
Sbjct: 1136 PTPSR--TETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATP-------- 1185
Query: 577 QWGQTAAAAKTRGGGDKQPGWQKA----AAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKP 632
+ + + + T D G Q+A AAG+ ++G GK+A A+GT + +KP
Sbjct: 1186 KLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTG--GKEA----ASGTTPQKSRKP 1239
Query: 633 WRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAE-------- 684
++G + A+ A + T G P + A + QE +
Sbjct: 1240 -KKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKE 1298
Query: 685 -ARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSG 743
+RK R+ K GD Q AA R KK +LG GG + S S+G
Sbjct: 1299 SSRKGWESRKRKLSGD--QPAA----RTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKA 1352
Query: 744 GAKSRSG--KKAAASKSHGGGGAK------RRRGGGAKSRSGEKAVTAGGQKAAAAGGKK 795
SG K+ S G GAK ++G G + + +K + KK
Sbjct: 1353 KRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKK 1412
Query: 796 PPRVKSRGGRGQKAA 810
K + + +KA+
Sbjct: 1413 DKEKKEKKKKAKKAS 1427
Score = 45.8 bits (107), Expect = 2e-04
Identities = 55/242 (22%), Positives = 92/242 (38%), Gaps = 20/242 (8%)
Query: 32 ELAAESAAPALSAAAAGVKIL-GSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQ 90
E + AA LS G + G+ +K R+ K AG +A + + Q W
Sbjct: 1208 EAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWP 1267
Query: 91 ------KAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQK 144
+A+ E+K TK +G + R+R ++ PR + +K
Sbjct: 1268 LNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKK 1327
Query: 145 SAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKK 204
AG G A + S+G K KA+ + + +GAK +E+ +
Sbjct: 1328 KLGAGE---GGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQ 1384
Query: 205 --------GRQREAKSRFGKTRGGRRKKHRRPKPAAGGAK--SRRGGGKKPQKQRRRGQK 254
G Q KS+ K + +RKK + K AK S + QK++++ +K
Sbjct: 1385 KGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKK 1444
Query: 255 AA 256
A
Sbjct: 1445 TA 1446
Score = 43.1 bits (100), Expect = 0.001
Identities = 103/454 (22%), Positives = 164/454 (36%), Gaps = 71/454 (15%)
Query: 34 AAESAAPALSAAAAGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAA 93
+A PA S + V+ G KLR+ K Q+ A + + +
Sbjct: 1064 SAVGTLPATSPQSTSVQ--AKGTNKLRKPKLP--------EVQQATKAPESSDDSEDSSD 1113
Query: 94 GAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNR 153
+ G+E G G Q A +A T LG + ++ AA S+ +S +G
Sbjct: 1114 SSSGSEEDGEGPQGAKSAHT--LGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTP 1171
Query: 154 G---AGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREA 210
G A +Q + A + S P ++ AK K + ++ G K +EA
Sbjct: 1172 GLTPANSQASKATPKLDSS----PSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEA 1227
Query: 211 KSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGG 270
S G +K R+PK AG ++ + Q GQ +++V S
Sbjct: 1228 AS------GTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLN-EAQVQASVVKV 1280
Query: 271 DKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQ 330
+L Q +R+ ++ + KG R K L G P + PR + +
Sbjct: 1281 LTELLEQ---------ERKKVVDTTKESSRKGWESRKRK-LSGDQP----AARTPRSKKK 1326
Query: 331 KATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLR 390
K A G GG+ V K K +R KAS GD K
Sbjct: 1327 KKLGA-------GEGGE-----ASVSPEKTSTTSKGKAKRDKAS---------GDVK--- 1362
Query: 391 EAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKP 450
E K +G + P QK G S PK+ K + + K+
Sbjct: 1363 EKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSN------PKSKKEKKKSDKRKKDKEK 1416
Query: 451 RRRGQKARQKAAEAGAESRGDKKQGRQKASAAGT 484
+ + +KA+ KA+ +ES KK+ ++K +A T
Sbjct: 1417 KEKKKKAK-KASTKDSESPSQKKKKKKKKTAEQT 1449
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 77.0 bits (188), Expect = 6e-14
Identities = 174/825 (21%), Positives = 288/825 (34%), Gaps = 100/825 (12%)
Query: 32 ELAAESAAPALSAAA------AGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEA 85
E E + PA AAA AG S D + GK + Q A +
Sbjct: 172 ETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTK 231
Query: 86 RQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKS 145
+KAA A G + G G R +KP + ++ GS+ +++
Sbjct: 232 ESPARKAAPAPG---KVGDVTPQVKGGALPPAKRAKKPEEESE-SSEEGSE-----SEEE 282
Query: 146 AAAGSKNRGAGAQKA----AAAAGVKSQGGE-----KPQKAAAAGAKSRSGKKPRRRGAK 196
A AG++++ ++K AA+A K G+ P KA A +++++GK +
Sbjct: 283 APAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESS 342
Query: 197 SRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQR-RRGQKA 255
S D + AK+ + A G S+ G P K+ R+G
Sbjct: 343 SEESSDSEEETPAAKALL--------------QAKASGKTSQVGAASAPAKESPRKGAAP 388
Query: 256 ATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQN 315
A GK+ ++ K R + ++ + A A KP+ K R + ++
Sbjct: 389 APPGKTGPAVAKAQAGK--REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKES 446
Query: 316 PRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAA-----VVGVKSRKKQRRRGKKPRR 370
PR G PR+ G A + + + + + + + + GK P+
Sbjct: 447 PRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQV 506
Query: 371 QKASAAGAKSRGGGDKKGLREAKRRGDGRKKP-----RWQNPRRRAQKAPAAKPRGGGSK 425
+ AS G G KG G P +W+ + + + G +
Sbjct: 507 KPASTMGMGPLG----KGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDG---E 559
Query: 426 KPRRRGPKAAKSRG----GKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKAS- 480
P P KS G K S K P QKA A + AE D + +++S
Sbjct: 560 VPTAVAPAQEKSLGNILQAKPTSSPAKGP---PQKAGPVAVQVKAEKPMDNSESSEESSD 616
Query: 481 AAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRV 540
+A ++ + + K + Q + T A AK + Q P AG +
Sbjct: 617 SADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV-APVRVGTQAPRKAGTATSP 675
Query: 541 GGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKA 600
GS AVA G + + T AK+ G G + KA
Sbjct: 676 AGS-----SPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQ----VKA 726
Query: 601 AAGVTKSRSGDGGKKAWRQKAAG--TGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGG 658
A+ K G G K T K+ K+ ++ + +E+A A+ A + S
Sbjct: 727 ASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVK 786
Query: 659 KQPRWQKPAAA------------GSESSAAAAVGQEAEARKKPRRRRAK-----SRGDG- 700
K PAAA G +AAA Q + ++ KP R + +RG
Sbjct: 787 KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 846
Query: 701 --GQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKS 758
AV + G + G S ++ A+ + SG A A +S
Sbjct: 847 VPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKES 906
Query: 759 HGGGGAKRRRG--GGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKS 801
G A G G + +++G++ + + + + G+ P V S
Sbjct: 907 PRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTS 951
>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
Length = 1512
Score = 76.3 bits (186), Expect = 1e-13
Identities = 124/565 (21%), Positives = 204/565 (36%), Gaps = 90/565 (15%)
Query: 34 AAESAAPALSAAAAGVKILGSGD----KKLRRQKAAAGGKKARLRGQKGAVAGKEARQH- 88
A +AA A +AAAA G K+L R K AGG++ R RG + AG+EA +
Sbjct: 63 APGTAAAAAAAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPR---AGQEAEKRR 119
Query: 89 -----WQKAAGAGGAENRGG--------------------GEQKAAAAGTKS--LGGRGR 121
+ G GGA + GG G AA A T + GG G
Sbjct: 120 VFSLPQPQQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGG 179
Query: 122 KP-RRRGQKAAATGSKKPRWRAQKSAAAGSKNR---------GAGAQKAAAAAGVKSQGG 171
P G + GS++ R ++S++ SK R G +A+ + S G
Sbjct: 180 SPASSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSG 239
Query: 172 EKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPA 231
E+ + A +G+ S SG RR+ A + + R++K+ +T+ + +P
Sbjct: 240 EERAEVAKSGSSSSSG--GRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEP- 296
Query: 232 AGGAKSRRGGGKKPQKQRRRGQKAATGGK---------SRVGKSR------GGGDKKLRR 276
K+ R +P+ RRR + GG+ S+ +SR GGG R
Sbjct: 297 ---PKAYREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSR 353
Query: 277 QGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAA 336
+ + ++RR + + +G G P + R R P R +++
Sbjct: 354 RLPRSPSPYSRRRSPSYSRHSSYERG-GDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSR 412
Query: 337 AAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRG 396
+ + R + + + SR + R P ++ A K EA R
Sbjct: 413 SPYSSRHSRSRSRHRL----SRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAA 468
Query: 397 DGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQK 456
+ A KA A + K + + ++G S +
Sbjct: 469 E-------------AAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDV 515
Query: 457 ARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAA 516
+ K A + S G G K A TK K + + + +KA G+++ +A
Sbjct: 516 KKIKIEHAPSPSSG----GTLKNDKAKTKPPLQVTKVENNLIVDKATKKAVIVGKESKSA 571
Query: 517 GAKSRGRKQPRRQKPAV--AGAKSR 539
K + KP GAK +
Sbjct: 572 ATKEESVSLKEKTKPLTPSIGAKEK 596
Score = 69.3 bits (168), Expect = 1e-11
Identities = 100/483 (20%), Positives = 169/483 (34%), Gaps = 66/483 (13%)
Query: 105 EQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSA--AAGSKNRGAGAQKAAA 162
E K A G + GGR + RRRG +A K+ + + G + G G
Sbjct: 88 EVKRLARGKRRAGGRQK--RRRGPRAGQEAEKRRVFSLPQPQQDGGGGASSGGGVTPLVE 145
Query: 163 AAGVKSQ--------GGEKPQKAAAAGAKSRSGKKP-RRRGAKSRGDEDKKGRQREAKSR 213
V SQ G A AAG SG P G + RG+ ++ +R+ +S
Sbjct: 146 YEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGSPASSSGTQRRGEGSERRPRRDRRSS 205
Query: 214 FGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKK 273
G+++ R ++HRR GG+++ + + R + A +G S G
Sbjct: 206 SGRSK-ERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKSGSSSSSG--------- 255
Query: 274 LRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKAT 333
G ++ +AT+ + K R + +S + K+P + ++
Sbjct: 256 -----------GRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDK 304
Query: 334 KAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAK 393
A +R + + +G + R + R + S + A GGG R
Sbjct: 305 TEPKAYRRR-----RSLSPLGGRDDSPVSHRASQSLRSRKSPSPA---GGGSSPYSRRLP 356
Query: 394 RRG---DGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGP-KAAKSRGGKSRSGGGKK 449
R R+ P + + + S R R P R GKSRS
Sbjct: 357 RSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYS 416
Query: 450 PRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAA 509
R ++R + + + + R + + T + L + KN R +A A
Sbjct: 417 SRHSRSRSRHRLS---------RSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARA 467
Query: 510 GEKATAA-----------GAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATS 558
E A AA AK+ P + + + S+ K ++ K A + S
Sbjct: 468 AEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPS 527
Query: 559 HGG 561
GG
Sbjct: 528 SGG 530
Score = 69.3 bits (168), Expect = 1e-11
Identities = 106/475 (22%), Positives = 169/475 (35%), Gaps = 76/475 (16%)
Query: 264 GKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGK 323
GK R GG +K RR+G A KRR + P + GG G S GG P
Sbjct: 95 GKRRAGGRQK-RRRGPRAGQEAEKRRVFSL----PQPQQDGGGGASSGGGVTPLVEYEDV 149
Query: 324 KPRRR-------GQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAA 376
+ AT A AAG G GG AS++
Sbjct: 150 SSQSEQGLLLGGASAATAATAAGGTGGSGGSP------------------------ASSS 185
Query: 377 GAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAK 436
G + RG G ++ R +R GR K R + RRR + ++ S+ +A
Sbjct: 186 GTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEV 245
Query: 437 SRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSH-- 494
++ G S S GG R+K+A A + S +K KA + TKS ++
Sbjct: 246 AKSGSSSSSGG----------RRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKE 295
Query: 495 ---------SGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKS------- 538
+ +RR + G + + + + R+ P+ AG S
Sbjct: 296 PPKAYREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRL 355
Query: 539 -RVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWG------QTAAAAKTRGGG 591
R SR+R + + ++ GG S + R + + +++R
Sbjct: 356 PRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPY 415
Query: 592 DKQPGWQKAAAGVTKSRSGDGG-KKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATG 650
+ ++ +++SRS + + A+ K R + A AAE A A
Sbjct: 416 SSRHSRSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAE 475
Query: 651 AT----SRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGG 701
AT + K P +E+SA+A+ + KK + A S GG
Sbjct: 476 ATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGG 530
Score = 48.5 bits (114), Expect = 2e-05
Identities = 53/219 (24%), Positives = 88/219 (40%), Gaps = 30/219 (13%)
Query: 508 AAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQR---------QKAVAAGATS 558
AA A AA + S P + +A K R GG + R+R ++ V +
Sbjct: 67 AAAAAAAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRVFSLPQP 126
Query: 559 HGGGGNKQSRGGGGNKPRQW--------------GQTAAAAKTRGGGDKQPGWQKAAAGV 604
GG S GGG ++ G +AA A T GG G A++
Sbjct: 127 QQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGSPASSSG 186
Query: 605 TKSRSGDGGKKAWRQKAAGTG-AKSRKKPWRR--GQKDAAAAEKAWATGATSRGSGGKQP 661
T+ R ++ R + + +G +K R + RR GQ+ + A K+ + + S +
Sbjct: 187 TQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVA 246
Query: 662 RWQKPAAAGSESSAAAAVGQEAEARK----KPRRRRAKS 696
+ +++G +A+A + +RK K R R KS
Sbjct: 247 KSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKS 285
Score = 43.1 bits (100), Expect = 0.001
Identities = 47/186 (25%), Positives = 74/186 (39%), Gaps = 47/186 (25%)
Query: 654 RGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINP--- 710
R +GG+Q R + P A GQEAE R+ + + G GG ++ G+ P
Sbjct: 97 RRAGGRQKRRRGPRA-----------GQEAEKRRVFSLPQPQQDGGGGASSGGGVTPLVE 145
Query: 711 WQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGA----------------------KSR 748
++ + G GG A + + + GSGG+ +S
Sbjct: 146 YEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGSPASSSGTQRRGEGSERRPRRDRRSS 205
Query: 749 SGKKAAASKSHGGGGAKRR---RGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGR 805
SG+ + H +RR RGG S+S + +G ++A A K S GGR
Sbjct: 206 SGRSKERHREH-----RRRDGQRGGSEASKSRSRHSHSGEERAEVA---KSGSSSSSGGR 257
Query: 806 GQKAAA 811
+ A+A
Sbjct: 258 RKSASA 263
Score = 35.8 bits (81), Expect = 0.17
Identities = 50/223 (22%), Positives = 80/223 (35%), Gaps = 29/223 (13%)
Query: 600 AAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWA--------TGA 651
AAA + S G ++ A G ++ RRG + AEK G
Sbjct: 72 AAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRVFSLPQPQQDGG 131
Query: 652 TSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPW 711
SGG + S+S +G + A + G GG A+ +
Sbjct: 132 GGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAA--GGTGGSGGSPASS--SGT 187
Query: 712 QRRG----KKPRLGKSRGGGGAKSR---------GSGGAKSRGSGGAKSRSGKK----AA 754
QRRG ++PR + G +K R GG+++ S S SG++ A
Sbjct: 188 QRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAK 247
Query: 755 ASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPP 797
+ S GG ++ + S S K + ++ K+PP
Sbjct: 248 SGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPP 290
>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
Length = 1452
Score = 76.3 bits (186), Expect = 1e-13
Identities = 124/565 (21%), Positives = 204/565 (36%), Gaps = 90/565 (15%)
Query: 34 AAESAAPALSAAAAGVKILGSGD----KKLRRQKAAAGGKKARLRGQKGAVAGKEARQH- 88
A +AA A +AAAA G K+L R K AGG++ R RG + AG+EA +
Sbjct: 63 APGTAAAAAAAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPR---AGQEAEKRR 119
Query: 89 -----WQKAAGAGGAENRGG--------------------GEQKAAAAGTKS--LGGRGR 121
+ G GGA + GG G AA A T + GG G
Sbjct: 120 VFSLPQPQQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGG 179
Query: 122 KP-RRRGQKAAATGSKKPRWRAQKSAAAGSKNR---------GAGAQKAAAAAGVKSQGG 171
P G + GS++ R ++S++ SK R G +A+ + S G
Sbjct: 180 SPASSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSG 239
Query: 172 EKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPA 231
E+ + A +G+ S SG RR+ A + + R++K+ +T+ + +P
Sbjct: 240 EERAEVAKSGSSSSSG--GRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEP- 296
Query: 232 AGGAKSRRGGGKKPQKQRRRGQKAATGGK---------SRVGKSR------GGGDKKLRR 276
K+ R +P+ RRR + GG+ S+ +SR GGG R
Sbjct: 297 ---PKAYREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSR 353
Query: 277 QGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAA 336
+ + ++RR + + +G G P + R R P R +++
Sbjct: 354 RLPRSPSPYSRRRSPSYSRHSSYERG-GDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSR 412
Query: 337 AAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRG 396
+ + R + + + SR + R P ++ A K EA R
Sbjct: 413 SPYSSRHSRSRSRHRL----SRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAA 468
Query: 397 DGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQK 456
+ A KA A + K + + ++G S +
Sbjct: 469 E-------------AAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDV 515
Query: 457 ARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAA 516
+ K A + S G G K A TK K + + + +KA G+++ +A
Sbjct: 516 KKIKIEHAPSPSSG----GTLKNDKAKTKPPLQVTKVENNLIVDKATKKAVIVGKESKSA 571
Query: 517 GAKSRGRKQPRRQKPAV--AGAKSR 539
K + KP GAK +
Sbjct: 572 ATKEESVSLKEKTKPLTPSIGAKEK 596
Score = 69.3 bits (168), Expect = 1e-11
Identities = 100/483 (20%), Positives = 169/483 (34%), Gaps = 66/483 (13%)
Query: 105 EQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSA--AAGSKNRGAGAQKAAA 162
E K A G + GGR + RRRG +A K+ + + G + G G
Sbjct: 88 EVKRLARGKRRAGGRQK--RRRGPRAGQEAEKRRVFSLPQPQQDGGGGASSGGGVTPLVE 145
Query: 163 AAGVKSQ--------GGEKPQKAAAAGAKSRSGKKP-RRRGAKSRGDEDKKGRQREAKSR 213
V SQ G A AAG SG P G + RG+ ++ +R+ +S
Sbjct: 146 YEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGSPASSSGTQRRGEGSERRPRRDRRSS 205
Query: 214 FGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKK 273
G+++ R ++HRR GG+++ + + R + A +G S G
Sbjct: 206 SGRSK-ERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKSGSSSSSG--------- 255
Query: 274 LRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKAT 333
G ++ +AT+ + K R + +S + K+P + ++
Sbjct: 256 -----------GRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDK 304
Query: 334 KAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAK 393
A +R + + +G + R + R + S + A GGG R
Sbjct: 305 TEPKAYRRR-----RSLSPLGGRDDSPVSHRASQSLRSRKSPSPA---GGGSSPYSRRLP 356
Query: 394 RRG---DGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGP-KAAKSRGGKSRSGGGKK 449
R R+ P + + + S R R P R GKSRS
Sbjct: 357 RSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYS 416
Query: 450 PRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAA 509
R ++R + + + + R + + T + L + KN R +A A
Sbjct: 417 SRHSRSRSRHRLS---------RSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARA 467
Query: 510 GEKATAA-----------GAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATS 558
E A AA AK+ P + + + S+ K ++ K A + S
Sbjct: 468 AEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPS 527
Query: 559 HGG 561
GG
Sbjct: 528 SGG 530
Score = 69.3 bits (168), Expect = 1e-11
Identities = 106/475 (22%), Positives = 169/475 (35%), Gaps = 76/475 (16%)
Query: 264 GKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGK 323
GK R GG +K RR+G A KRR + P + GG G S GG P
Sbjct: 95 GKRRAGGRQK-RRRGPRAGQEAEKRRVFSL----PQPQQDGGGGASSGGGVTPLVEYEDV 149
Query: 324 KPRRR-------GQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAA 376
+ AT A AAG G GG AS++
Sbjct: 150 SSQSEQGLLLGGASAATAATAAGGTGGSGGSP------------------------ASSS 185
Query: 377 GAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAK 436
G + RG G ++ R +R GR K R + RRR + ++ S+ +A
Sbjct: 186 GTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEV 245
Query: 437 SRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSH-- 494
++ G S S GG R+K+A A + S +K KA + TKS ++
Sbjct: 246 AKSGSSSSSGG----------RRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKE 295
Query: 495 ---------SGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKS------- 538
+ +RR + G + + + + R+ P+ AG S
Sbjct: 296 PPKAYREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRL 355
Query: 539 -RVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWG------QTAAAAKTRGGG 591
R SR+R + + ++ GG S + R + + +++R
Sbjct: 356 PRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPY 415
Query: 592 DKQPGWQKAAAGVTKSRSGDGG-KKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATG 650
+ ++ +++SRS + + A+ K R + A AAE A A
Sbjct: 416 SSRHSRSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAE 475
Query: 651 AT----SRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGG 701
AT + K P +E+SA+A+ + KK + A S GG
Sbjct: 476 ATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGG 530
Score = 48.5 bits (114), Expect = 2e-05
Identities = 53/219 (24%), Positives = 88/219 (40%), Gaps = 30/219 (13%)
Query: 508 AAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQR---------QKAVAAGATS 558
AA A AA + S P + +A K R GG + R+R ++ V +
Sbjct: 67 AAAAAAAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRVFSLPQP 126
Query: 559 HGGGGNKQSRGGGGNKPRQW--------------GQTAAAAKTRGGGDKQPGWQKAAAGV 604
GG S GGG ++ G +AA A T GG G A++
Sbjct: 127 QQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGSPASSSG 186
Query: 605 TKSRSGDGGKKAWRQKAAGTG-AKSRKKPWRR--GQKDAAAAEKAWATGATSRGSGGKQP 661
T+ R ++ R + + +G +K R + RR GQ+ + A K+ + + S +
Sbjct: 187 TQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVA 246
Query: 662 RWQKPAAAGSESSAAAAVGQEAEARK----KPRRRRAKS 696
+ +++G +A+A + +RK K R R KS
Sbjct: 247 KSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKS 285
Score = 43.1 bits (100), Expect = 0.001
Identities = 47/186 (25%), Positives = 74/186 (39%), Gaps = 47/186 (25%)
Query: 654 RGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINP--- 710
R +GG+Q R + P A GQEAE R+ + + G GG ++ G+ P
Sbjct: 97 RRAGGRQKRRRGPRA-----------GQEAEKRRVFSLPQPQQDGGGGASSGGGVTPLVE 145
Query: 711 WQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGA----------------------KSR 748
++ + G GG A + + + GSGG+ +S
Sbjct: 146 YEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGSPASSSGTQRRGEGSERRPRRDRRSS 205
Query: 749 SGKKAAASKSHGGGGAKRR---RGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGR 805
SG+ + H +RR RGG S+S + +G ++A A K S GGR
Sbjct: 206 SGRSKERHREH-----RRRDGQRGGSEASKSRSRHSHSGEERAEVA---KSGSSSSSGGR 257
Query: 806 GQKAAA 811
+ A+A
Sbjct: 258 RKSASA 263
Score = 35.8 bits (81), Expect = 0.17
Identities = 50/223 (22%), Positives = 80/223 (35%), Gaps = 29/223 (13%)
Query: 600 AAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWA--------TGA 651
AAA + S G ++ A G ++ RRG + AEK G
Sbjct: 72 AAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRVFSLPQPQQDGG 131
Query: 652 TSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPW 711
SGG + S+S +G + A + G GG A+ +
Sbjct: 132 GGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAA--GGTGGSGGSPASS--SGT 187
Query: 712 QRRG----KKPRLGKSRGGGGAKSR---------GSGGAKSRGSGGAKSRSGKK----AA 754
QRRG ++PR + G +K R GG+++ S S SG++ A
Sbjct: 188 QRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAK 247
Query: 755 ASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPP 797
+ S GG ++ + S S K + ++ K+PP
Sbjct: 248 SGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPP 290
>gi|62122917 filaggrin family member 2 [Homo sapiens]
Length = 2391
Score = 74.3 bits (181), Expect = 4e-13
Identities = 157/757 (20%), Positives = 263/757 (34%), Gaps = 103/757 (13%)
Query: 94 GAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAA---ATGSKKPRWRAQKSA--AA 148
G+G ++ G G+ +G+ G G+ R GQ + ++GS + Q + +
Sbjct: 584 GSGSGQSSGFGQH---GSGSGQSSGFGQHESRSGQSSYGQHSSGSSQSSGYGQHGSRQTS 640
Query: 149 GSKNRGAGAQKAAAAAGVKSQGGEKP---QKAAAAGAKSRSGKKPRRRGAKSRGDEDKKG 205
G G+G+ ++ S G+ Q + +G S G+ R G S G
Sbjct: 641 GFGQHGSGSSQSTGFGQYGSGSGQSSGFGQHVSGSGQSSGFGQHESRSGHSSYGQHGFGS 700
Query: 206 RQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGK 265
Q + G + G +G + G+ GQ + G+S
Sbjct: 701 SQSSGYGQHGSSSG----------QTSGFGQHELSSGQSSSF----GQHGSGSGQSSGFG 746
Query: 266 SRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKP 325
G G + GQ+ + +G G ++G ++ G G G + G G G +
Sbjct: 747 QHGSGSGQSSGFGQHESRSGQSSYGQHSSGSSQSS-GYGQHGSRQTSGFGQH-GSGSSQS 804
Query: 326 RRRGQKATKAA-AAGTKRGGGGQQKAAVVGV-KSRKKQRRRGKKPRRQKASAAGAKSRGG 383
GQ + + +AG + G G +++ G +SR Q G+ +G+ G
Sbjct: 805 TGFGQYGSGSGQSAGFGQHGSGSGQSSGFGQHESRSHQSSYGQH-------GSGSSQSSG 857
Query: 384 GDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSR 443
+ G + G G+ R + + G GS + G G
Sbjct: 858 YGQHGSSSGQTSGFGQH-------RSSSGQYSGFGQHGSGSGQSSGFGQHGT---GSGQY 907
Query: 444 SGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRG 503
SG G+ R Q + + ++S G + G G G SG G
Sbjct: 908 SGFGQHESRSHQSSYGQHGSGSSQSSGYGQHGSSSGQTFGFGQHRSGSGQSSGF-----G 962
Query: 504 QKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGG 563
Q +G+ + Q + +G S G +SR Q + HG G
Sbjct: 963 QHGSGSGQSSGFG------------QHESGSGKSSGFGQHESRSSQ----SNYGQHGSGS 1006
Query: 564 NKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAG 623
++ S G G GQT + R + G+ + +G +S SG G +++G
Sbjct: 1007 SQSS--GYGQHGSSSGQTTGFGQHRSSSGQYSGFGQHGSGSDQS-SGFGQHGTGSGQSSG 1063
Query: 624 TGA-KSRKKPWRRGQKDAAAAEKA-----WATGATSRGSGGKQPRWQKPAA---AGSESS 674
G +SR + GQ + +++ + + + G G +P + + GS S
Sbjct: 1064 FGQYESRSRQSSYGQHGSGSSQSSGYGQHGSNSGQTSGFGQHRPGSGQSSGFGQYGSGSG 1123
Query: 675 AAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGG-GAKSRG 733
++ GQ KS G G + + + G G S+ G G G
Sbjct: 1124 QSSGFGQHGSG-------TGKSSGFAQHEYRSGQSSYGQHG----TGSSQSSGCGQHESG 1172
Query: 734 SGGAKSRG-----------SGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVT 782
SG S G SG S SG+ + G G G G +S+ E T
Sbjct: 1173 SGPTTSFGQHVSGSDNFSSSGQHISDSGQSTGFGQYGSGSGQSTGLGQG-ESQQVESGST 1231
Query: 783 AGGQKAAAAGGKKPPRVKSRGGRGQKAAAGGKKPLRR 819
G++ G S+ G+GQ G + RR
Sbjct: 1232 VHGRQETTHGQTINTTRHSQSGQGQSTQTGSRVTRRR 1268
Score = 72.8 bits (177), Expect = 1e-12
Identities = 170/830 (20%), Positives = 284/830 (34%), Gaps = 145/830 (17%)
Query: 50 KILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAG-------AGGAENRG 102
K+ + +K L ++ A G K RG + E + + G + +E
Sbjct: 80 KLTMACNKVLSKEYCKASGSKKHRRGHRHQEEESETEEDEEDTPGHKSGYRHSSWSEGEE 139
Query: 103 GGEQKAAAAGTKSL--GGRGRKPRRRGQKAAATGSKKPRWRAQKSAA----AGSKNRGAG 156
G + GT G R+ R+G +++ + + R +S+ +G K+R
Sbjct: 140 HGYSSGHSRGTVKCRHGSNSRRLGRQGNLSSSGNQEGSQKRYHRSSCGHSWSGGKDRHGS 199
Query: 157 AQKAAAAAGVKS------QGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREA 210
+ KS + GE+ + + + + R G G ++ G E + R
Sbjct: 200 SSVELRERINKSHISPSRESGEEYESGSGSNSWERKGHGGLSCGLETSGHESNSTQSRIR 259
Query: 211 KSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGG 270
+ + G + G RR A G + G G+ PQ Q GG+ G
Sbjct: 260 EQKLGSSCSGSGDSGRRSH--ACGYSNSSGCGR-PQNASSSCQSHRFGGQGNQFSYIQSG 316
Query: 271 DKKLRRQGQ-NAALAGAKRRGAATAGEKPAAKGRGGRG--------PKSLGGQNPRWGRG 321
+ + GQ + ++G + G P ++ RG P++ GGQ W G
Sbjct: 317 CQSGIKGGQGHGCVSGGQPSGCGQPESNPCSQSYSQRGYGARENGQPQNCGGQ---WRTG 373
Query: 322 GKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSR 381
+ GQ G GG Q + Q G R +S++ S+
Sbjct: 374 SSQSSCCGQY-----------GSGGSQSCS-------NGQHEYGSCGRFSNSSSSNEFSK 415
Query: 382 GGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGK 441
+ G G + S + G ++S G +
Sbjct: 416 ----------CDQYGSGSSQ----------------------STSFEQHGTGLSQSSGFE 443
Query: 442 SRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWR 501
G GQ Q + + ++S G + G +G G G SG
Sbjct: 444 QHVCGS------GQTCGQHESTS-SQSLGYDQHGSSSGKTSGFGQHGSGSGQSSGF---- 492
Query: 502 RGQKAEAAGEKATAAGAKS-RGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVA---AGAT 557
GQ +G+ + S G+ Q +V+G S G +SR RQ + +G++
Sbjct: 493 -GQCGSGSGQSSGFGQHGSVSGQSSGFGQHGSVSGQSSGFGQHESRSRQSSYGQHGSGSS 551
Query: 558 SHGGGGNKQSR--GGGGNKPRQWGQTAAAAKTRGGGDKQPGW--------QKAAAGVTKS 607
G G SR G G GQ+ + G + G+ Q + G +S
Sbjct: 552 QSSGYGQYGSRETSGFGQHGLGSGQSTGFGQYGSGSGQSSGFGQHGSGSGQSSGFGQHES 611
Query: 608 RSGD---GGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQ 664
RSG G + +++G G ++ GQ + +++ +TG GSG Q
Sbjct: 612 RSGQSSYGQHSSGSSQSSGYGQHGSRQTSGFGQHGSGSSQ---STGFGQYGSGSGQSSGF 668
Query: 665 KPAAAGSESSAAAAVGQEAEARKKPRRR---RAKSRGDG------GQNAAVGINPWQRRG 715
+GS S+ + + ++S G G GQ + G + G
Sbjct: 669 GQHVSGSGQSSGFGQHESRSGHSSYGQHGFGSSQSSGYGQHGSSSGQTSGFGQHELSS-G 727
Query: 716 KKPRLGKSRGGGGAKS----RGSGGAKSRGSGGAKSRSGKKAAASKSHG-------GGGA 764
+ G+ G G S GSG +S G G +SRSG+ + S G G
Sbjct: 728 QSSSFGQHGSGSGQSSGFGQHGSGSGQSSGFGQHESRSGQSSYGQHSSGSSQSSGYGQHG 787
Query: 765 KRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGRGQKAAAGGK 814
R+ G + SG T GQ + +G G GQ + G+
Sbjct: 788 SRQTSGFGQHGSGSSQSTGFGQYGSGSG--------QSAGFGQHGSGSGQ 829
Score = 60.8 bits (146), Expect = 5e-09
Identities = 151/769 (19%), Positives = 251/769 (32%), Gaps = 89/769 (11%)
Query: 43 SAAAAGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAA--GAGGAEN 100
S+ + G GSG + +A G+ GQ E+R H G+G +++
Sbjct: 801 SSQSTGFGQYGSGSGQ-----SAGFGQHGSGSGQSSGFGQHESRSHQSSYGQHGSGSSQS 855
Query: 101 RGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKA 160
G G+ +++ T G + R +G + + +S+ G G+G
Sbjct: 856 SGYGQHGSSSGQTSGFG------QHRSSSGQYSGFGQHGSGSGQSSGFGQHGTGSGQYSG 909
Query: 161 AAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGG 220
+S Q + + S G+ G + + G + S FG+ G
Sbjct: 910 FGQHESRSHQSSYGQHGSGSSQSSGYGQHGSSSGQTFGFGQHRSGSGQS--SGFGQHGSG 967
Query: 221 RRKKHRRPKPAAGGAKSRRGGGKKPQK-QRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQ 279
+ + +G KS G + + Q GQ + +S G + GQ
Sbjct: 968 SGQSSGFGQHESGSGKSSGFGQHESRSSQSNYGQHGSGSSQSSGYGQHGSSSGQTTGFGQ 1027
Query: 280 NAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAG 339
+ + +G + G G G S GQ+ +G+ + R Q + +G
Sbjct: 1028 HRSSSGQYSGFGQHGSGSDQSSGFGQHGTGS--GQSSGFGQYESRSR---QSSYGQHGSG 1082
Query: 340 TKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGR 399
+ + G Q + G S Q R G ++S G G G G + G G+
Sbjct: 1083 SSQSSGYGQHGSNSGQTSGFGQHRPGSG----QSSGFGQYGSGSGQSSGFGQ-HGSGTGK 1137
Query: 400 KKPRWQNPRRRAQKAPAAKPRG-----GGSKKPRRRGPKAAK-----------------S 437
Q+ R Q + G G + GP + S
Sbjct: 1138 SSGFAQHEYRSGQSSYGQHGTGSSQSSGCGQHESGSGPTTSFGQHVSGSDNFSSSGQHIS 1197
Query: 438 RGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGT------KSRGGGL 491
G+S +G G+ GQ E+ G GRQ+ + T G G
Sbjct: 1198 DSGQS-TGFGQYGSGSGQSTGLGQGESQQVESGSTVHGRQETTHGQTINTTRHSQSGQGQ 1256
Query: 492 KSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKA 551
+ +G + RR + +++ + S + + AG+ GS R+RQ
Sbjct: 1257 STQTGSRVTRRRRSSQSENSDSEVHSKVSHRHSEHIHTQ---AGSHYPKSGSTVRRRQGT 1313
Query: 552 V---AAGATSHGGGGNKQSRGGGGN---KPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVT 605
T HG G+ QS G + R A ++ G +P Q+
Sbjct: 1314 THGQRGDTTRHGHSGHGQSTQTGSRTSGRQRFSHSDATDSEVHSGVSHRPHSQEQTHSQA 1373
Query: 606 KSRSGDGGKKAWRQ---------KAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGS 656
S+ G+ + +A G G + +RG + + + S
Sbjct: 1374 GSQHGESESTVHERHETTYGQTGEATGHGHSGHGQSTQRGSRTTGRRGSGHSESSDSEVH 1433
Query: 657 GGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGK 716
G R Q E + A Q E+ R + G G + GK
Sbjct: 1434 SGGSHRPQS-----QEQTHGQAGSQHGESGSTVHGRHGTTHGQTGDTTR---HAHYHHGK 1485
Query: 717 KPRLGKSRGGGGAKSRGSGGAKSRGS----GGAKSRSGKKAAASKSHGG 761
+ G S G RGSG ++S S GG+ + SG S S G
Sbjct: 1486 STQRGSSTTG----RRGSGHSESSDSEVHSGGSHTHSGHTHGQSGSQHG 1530
Score = 57.4 bits (137), Expect = 5e-08
Identities = 158/832 (18%), Positives = 266/832 (31%), Gaps = 129/832 (15%)
Query: 76 QKGAVAGKEARQHWQKAAGAGGAENRG-GGEQKAAAAGTKSLGGRGR-KPRRRGQKAAAT 133
Q G +H G A G G ++ G+++ G RG + +
Sbjct: 1376 QHGESESTVHERHETTYGQTGEATGHGHSGHGQSTQRGSRTTGRRGSGHSESSDSEVHSG 1435
Query: 134 GSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKS--RSGKKPR 191
GS +P+ + Q AGS++ +G+ Q G+ + A KS R
Sbjct: 1436 GSHRPQSQEQTHGQAGSQHGESGSTVHGRHGTTHGQTGDTTRHAHYHHGKSTQRGSSTTG 1495
Query: 192 RRGAKSRGDEDKKGRQREAKSRFGKTRGGR-----------RKKHRRPKPAAGGAKSRRG 240
RRG+ D + + + G T G +HR G
Sbjct: 1496 RRGSGHSESSDSEVHSGGSHTHSGHTHGQSGSQHGESESIIHDRHRITHGQTGDTTRHSY 1555
Query: 241 GGKKPQKQ---RRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAK---------- 287
G + Q R G++ + +S + GG + + AG++
Sbjct: 1556 SGHEQTTQTGSRTTGRQRTSHSESTDSEVHSGGSHRPHSREHTYGQAGSQHEEPEFTVHE 1615
Query: 288 RRGAA------TAGEKPAAKGRGG-RGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGT 340
R G T G + G+ RG ++ G Q G T
Sbjct: 1616 RHGTTHGQIGDTTGHSHSGHGQSTQRGSRTTGRQRSSHSESSDSEVHSGVSHTHTGHTHG 1675
Query: 341 KRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRK 400
+ G Q ++V + + G R G + G R RRG G
Sbjct: 1676 QAGSQHGQSESIVPERHGTTHGQTGDTTRHAHYH------HGLTTQTGSRTTGRRGSGHS 1729
Query: 401 K-----------------PRWQNPRRRAQKAPAAKPRGG--------------------- 422
+ Q + + R G
Sbjct: 1730 EYSDSEGYSGVSHTHSGHTHGQARSQHGESESIVHERHGTIHGQTGDTTRHAHSGHGQST 1789
Query: 423 --GSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAG-AESRGDKKQGR--- 476
GS+ RR ++ + SG ++P RG Q ++ G +ES D++ G
Sbjct: 1790 QTGSRTTGRRSSGHSEYSDSEGHSGFSQRPHSRGHTHGQAGSQHGESESIVDERHGTTHG 1849
Query: 477 QKASAAGTKSRGGGLKSHSGKNLW--RRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVA 534
Q +G G G + SG + RR +E++ + + G+ + +
Sbjct: 1850 QTGDTSGHSQSGHGQSTQSGSSTTGRRRSGHSESSDSEVHSGGSHTHSGHTHSQ------ 1903
Query: 535 GAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQT----AAAAKTRGG 590
A+S+ G S+S ++ T+HG G+ G + GQT + RG
Sbjct: 1904 -ARSQHGESESTVHKR----HQTTHGQTGDTTEHGHPSH-----GQTIQTGSRTTGRRGS 1953
Query: 591 GDKQPGWQKAAAGVTKSRSG-DGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWAT 649
G + + +GV+ + SG G+ +G+ R D +
Sbjct: 1954 GHSEYSDSEGPSGVSHTHSGHTHGQAGSHYPESGSSVHERHGTTHGQTADTTRHGHSGHG 2013
Query: 650 GATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGIN 709
+T RGS R A S + + G + ++ G Q+ G +
Sbjct: 2014 QSTQRGSRTTGRR------ASGHSEYSDSEGHSGVSHTHSGHAHGQA---GSQHGESGSS 2064
Query: 710 PWQRRG-KKPRLGKS-----RGGGGAKSRGSGGAKSRGSGGAKSRSGK-KAAASKSHGGG 762
+R G + G + G G + RGS A RGSG ++S + + S +H G
Sbjct: 2065 VHERHGTTHGQTGDTTRHAHSGHGQSTQRGSRTAGRRGSGHSESSDSEVHSGVSHTHSG- 2123
Query: 763 GAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGRGQKAAAGGK 814
G A+S+ GE G++ G + G GQ G +
Sbjct: 2124 ----HTYGQARSQHGESGSAIHGRQGTIHGQTGDTTRHGQSGHGQSTQTGSR 2171
Score = 55.8 bits (133), Expect = 2e-07
Identities = 152/769 (19%), Positives = 261/769 (33%), Gaps = 100/769 (13%)
Query: 66 AGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRR 125
+G ++ GQ G+ +G+ A Q +G+G + G E ++ + G +
Sbjct: 799 SGSSQSTGFGQYGSGSGQSAG-FGQHGSGSGQSSGFGQHESRSHQSSYGQHGSGSSQSSG 857
Query: 126 RGQKAAATGSKKP--RWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAK 183
GQ +++G + R+ +G G+G+ +++ Q +G
Sbjct: 858 YGQHGSSSGQTSGFGQHRSSSGQYSGFGQHGSGSGQSSGFG----------QHGTGSGQY 907
Query: 184 SRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGK 243
S G+ R S G Q + G + G G + R G G+
Sbjct: 908 SGFGQHESRSHQSSYGQHGSGSSQSSGYGQHGSSSG----------QTFGFGQHRSGSGQ 957
Query: 244 KP---QKQRRRGQKAATGG-KSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPA 299
Q GQ + G +S GKS G G + R N G+ ++ G+ +
Sbjct: 958 SSGFGQHGSGSGQSSGFGQHESGSGKSSGFGQHESRSSQSNYGQHGSGSSQSSGYGQHGS 1017
Query: 300 AKGR--GGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKS 357
+ G+ G +S GQ +G+ G + ++ + G G Q + +S
Sbjct: 1018 SSGQTTGFGQHRSSSGQYSGFGQHGS--------GSDQSSGFGQHGTGSGQSSGFGQYES 1069
Query: 358 RKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAA 417
R +Q G+ +G+ G + G + G G+ +P + ++
Sbjct: 1070 RSRQSSYGQH-------GSGSSQSSGYGQHGSNSGQTSGFGQHRPG-------SGQSSGF 1115
Query: 418 KPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRG--DKKQG 475
G GS + G + + GKS SG + R GQ + + ++S G + G
Sbjct: 1116 GQYGSGSGQSSGFGQHGSGT--GKS-SGFAQHEYRSGQSSYGQHGTGSSQSSGCGQHESG 1172
Query: 476 RQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAG 535
++ G G S SG+++ GQ G+ + +G +S G Q Q+
Sbjct: 1173 SGPTTSFGQHVSGSDNFSSSGQHISDSGQST-GFGQYGSGSG-QSTGLGQGESQQ---VE 1227
Query: 536 AKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAK--------- 586
+ S V G + + + S G G G + R+ Q+ +
Sbjct: 1228 SGSTVHGRQETTHGQTINTTRHSQSGQGQSTQTGSRVTRRRRSSQSENSDSEVHSKVSHR 1287
Query: 587 ------TRGGGD--KQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRR-GQ 637
T+ G K + G T + GD + T SR +R
Sbjct: 1288 HSEHIHTQAGSHYPKSGSTVRRRQGTTHGQRGDTTRHGHSGHGQSTQTGSRTSGRQRFSH 1347
Query: 638 KDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSR 697
DA +E +G + R +Q Q AGS+ + + E + A
Sbjct: 1348 SDATDSEVH--SGVSHRPHSQEQTHSQ----AGSQHGESESTVHERHETTYGQTGEATGH 1401
Query: 698 GDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASK 757
G G + +RG + R G G S GS +S+ A
Sbjct: 1402 GHSGHGQST------QRGSRTT---GRRGSGHSESSDSEVHSGGSHRPQSQEQTHGQAGS 1452
Query: 758 SHG-GGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGR 805
HG G R G ++G+ + A GK R S GR
Sbjct: 1453 QHGESGSTVHGRHGTTHGQTGDTT-----RHAHYHHGKSTQRGSSTTGR 1496
Score = 40.4 bits (93), Expect = 0.007
Identities = 110/628 (17%), Positives = 191/628 (30%), Gaps = 111/628 (17%)
Query: 205 GRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVG 264
GR+ S + + G H G A+S+ G + +R TG +R
Sbjct: 1722 GRRGSGHSEYSDSEGYSGVSHTHSGHTHGQARSQHGESESIVHERHGTIHGQTGDTTRHA 1781
Query: 265 KSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKK 324
S G + G++ G ++G + G G ++
Sbjct: 1782 HSGHG----------QSTQTGSRTTGRRSSGHSEYSDSEGHSG-------------FSQR 1818
Query: 325 PRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGG 384
P RG G G Q + + G+ S +G G
Sbjct: 1819 PHSRGHT----------HGQAGSQHGESESIVDERHGTTHGQTGDTSGHSQSG---HGQS 1865
Query: 385 DKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRS 444
+ G RR G + + ++ GGS A+S+ G+S S
Sbjct: 1866 TQSGSSTTGRRRSGHSE------------SSDSEVHSGGSHTHSGHTHSQARSQHGESES 1913
Query: 445 GGGKKPR----------RRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSH 494
K+ + G + + + G+ + G + G + S ++ G +H
Sbjct: 1914 TVHKRHQTTHGQTGDTTEHGHPSHGQTIQTGSRTTGRRGSGHSEYS--DSEGPSGVSHTH 1971
Query: 495 SGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKA--- 551
SG + G +G + G+ + +S GS++ R+ +
Sbjct: 1972 SGHTHGQAGSHYPESGSSVHERHGTTHGQTADTTRHGHSGHGQSTQRGSRTTGRRASGHS 2031
Query: 552 VAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGD 611
+ + H G + S G Q G++ ++ R G T ++GD
Sbjct: 2032 EYSDSEGHSGVSHTHSGHAHGQAGSQHGESGSSVHERHG-------------TTHGQTGD 2078
Query: 612 GGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGS 671
+ A T SR RRG + +++ +G + SG
Sbjct: 2079 TTRHAHSGHGQSTQRGSRTAG-RRGSGHSESSDSEVHSGVSHTHSG-------------- 2123
Query: 672 ESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKS 731
+ A Q E+ R+ G G R G+S G ++
Sbjct: 2124 -HTYGQARSQHGESGSAIHGRQGTIHGQTGDTT--------------RHGQSGHGQSTQT 2168
Query: 732 RGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAA 791
+ R S S S + AS +H G A SR G+ + G++
Sbjct: 2169 GSRTTGRQRSSHSESSDSEVHSEASPTHSG-----HTHSQAGSRHGQSGSSGHGRQGTTH 2223
Query: 792 GGKKPPRVKSRGGRGQKAAAGGKKPLRR 819
G + G GQ G + RR
Sbjct: 2224 GQTGDTTRHAHYGYGQSTQRGSRTTGRR 2251
Score = 40.0 bits (92), Expect = 0.009
Identities = 154/850 (18%), Positives = 267/850 (31%), Gaps = 130/850 (15%)
Query: 75 GQKGAVAGKEA---------RQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGG-RGRKPR 124
GQ G +G+ + RQ G+G +++ G G+ + + T G R +
Sbjct: 1052 GQHGTGSGQSSGFGQYESRSRQSSYGQHGSGSSQSSGYGQHGSNSGQTSGFGQHRPGSGQ 1111
Query: 125 RRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKS 184
G +GS + Q + G K+ G + + Q G +++ G +
Sbjct: 1112 SSGFGQYGSGSGQSSGFGQHGSGTG-KSSGFAQHEYRSGQSSYGQHGTGSSQSSGCG-QH 1169
Query: 185 RSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRG-GRRKKHRRPKPAAGGAKSRR---G 240
SG P + D + S G++ G G+ G +S++ G
Sbjct: 1170 ESGSGPTTSFGQHVSGSDNFSSSGQHISDSGQSTGFGQYGSGSGQSTGLGQGESQQVESG 1229
Query: 241 GGKKPQKQRRRGQKAATGGKSRVGKSR----GGGDKKLRRQGQNAALAGAKRRGAATAGE 296
+++ GQ T S+ G+ + G + RR Q+ +
Sbjct: 1230 STVHGRQETTHGQTINTTRHSQSGQGQSTQTGSRVTRRRRSSQSENSDSEVHSKVSHRHS 1289
Query: 297 KPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVK 356
+ G PKS G RRR T+ G G ++ G +
Sbjct: 1290 EHIHTQAGSHYPKS-----------GSTVRRRQGTTHGQRGDTTRHGHSGHGQSTQTGSR 1338
Query: 357 SRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPA 416
+ +QR + + + ++ + + G+ ++ Q A
Sbjct: 1339 TSGRQRFSHSDATDSEVHSGVSHRPHSQEQTHSQAGSQHGESESTVHERHETTYGQTGEA 1398
Query: 417 A--------KPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAG--- 465
+ GS+ RRG ++S + SGG +P+ + Q Q ++ G
Sbjct: 1399 TGHGHSGHGQSTQRGSRTTGRRGSGHSESSDSEVHSGGSHRPQSQEQTHGQAGSQHGESG 1458
Query: 466 ---------------------------AESRGDKKQGRQ---KASAAGTKSRGGGLKSHS 495
+ RG GR+ + ++ ++ GG +HS
Sbjct: 1459 STVHGRHGTTHGQTGDTTRHAHYHHGKSTQRGSSTTGRRGSGHSESSDSEVHSGGSHTHS 1518
Query: 496 GKNLWRRGQKAEAAGEKATAAGAKSR---GRKQPRRQKPAVAGAKSRVGGSKSRQRQKAV 552
G GQ GE + + R G+ + ++ GS++ RQ+
Sbjct: 1519 GHT---HGQSGSQHGESESIIHDRHRITHGQTGDTTRHSYSGHEQTTQTGSRTTGRQR-- 1573
Query: 553 AAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQ-KAAAGVTKSRSGD 611
TSH + + GG ++P T A G ++P + G T + GD
Sbjct: 1574 ----TSHSESTDSEVHSGGSHRPHSREHTYGQA---GSQHEEPEFTVHERHGTTHGQIGD 1626
Query: 612 ------GGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQK 665
G Q+ + T + R + + TG T +G + + +
Sbjct: 1627 TTGHSHSGHGQSTQRGSRTTGRQRSSHSESSDSEVHSGVSHTHTGHTHGQAGSQHGQSES 1686
Query: 666 --PAAAGSESSAAAAV--------GQEAEARKKPRRRRAKSRGD--------GGQNAAVG 707
P G+ G + + RR + G + G
Sbjct: 1687 IVPERHGTTHGQTGDTTRHAHYHHGLTTQTGSRTTGRRGSGHSEYSDSEGYSGVSHTHSG 1746
Query: 708 INPWQRRGK--------KPRLGKSRGGGGAKSR----GSGGAKSRGSGGAKSRSGKKAAA 755
Q R + R G G G +R G G + GS RS +
Sbjct: 1747 HTHGQARSQHGESESIVHERHGTIHGQTGDTTRHAHSGHGQSTQTGSRTTGRRSSGHSEY 1806
Query: 756 SKSHGGGGAKRR---RG---GGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGRGQKA 809
S S G G +R RG G A S+ GE + G S+ G GQ
Sbjct: 1807 SDSEGHSGFSQRPHSRGHTHGQAGSQHGESESIVDERHGTTHGQTGDTSGHSQSGHGQST 1866
Query: 810 AAGGKKPLRR 819
+G RR
Sbjct: 1867 QSGSSTTGRR 1876
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 73.2 bits (178), Expect = 9e-13
Identities = 95/555 (17%), Positives = 182/555 (32%), Gaps = 78/555 (14%)
Query: 74 RGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRG----QK 129
RG G +HWQ G +++G GE + G K L + +R G QK
Sbjct: 654 RGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQK 713
Query: 130 AAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKK 189
G +K R Q+ G + G G ++ G++ ++ G G+
Sbjct: 714 EREQGHQKER--NQEMEEGGEEEHGEGEEEE----------GDREEEEEKEGEGKEEGEG 761
Query: 190 PRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQR 249
G + + + ++K +R K G+ G + + G K G + + +
Sbjct: 762 EEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEE 821
Query: 250 RRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPK 309
+G++ + + G G+++ + + G GE+ +G G +
Sbjct: 822 GKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEE 881
Query: 310 SLGGQNPRWGRG-GKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKP 368
G+ G G G++ G+ + G + G G
Sbjct: 882 EGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEG---------------------- 919
Query: 369 RRQKASAAGAKSRGGGDKKGLREAKRRGDG---RKKPRWQNPRRRAQKAPAAKPRGGGSK 425
K G + G G+++ G+G ++ W+ + G G +
Sbjct: 920 ---KGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGE--------GEGEE 968
Query: 426 KPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRG---DKKQGRQKASAA 482
+ G + G+ G G+ G++ ++ E E G ++++G +
Sbjct: 969 EGEGEGEEGEGE--GEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVE 1026
Query: 483 GTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGG 542
G + G G ++ E GE+ G R+ R++ K + G
Sbjct: 1027 GEEGEGEG-----------EEEEGEEEGEEREKEGEGEENRR--NREEEEEEEGKYQETG 1073
Query: 543 SKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAA 602
+ +RQ S G K + + Q + T+G G +Q +
Sbjct: 1074 EEENERQDGEEYKKVSKIKGSVKYGK-------HKTYQKKSVTNTQGNGKEQRSKMPVQS 1126
Query: 603 GVTKSRSGDGGKKAW 617
G KK W
Sbjct: 1127 KRLLKNGPSGSKKFW 1141
Score = 68.2 bits (165), Expect = 3e-11
Identities = 97/550 (17%), Positives = 195/550 (35%), Gaps = 35/550 (6%)
Query: 234 GAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQN----AALAGAKRR 289
GA+ +G G + Q+ + K GG +K + A ++ K +
Sbjct: 592 GAEDSKGNGIEEQEVEANEENV---------KVHGGRKEKTEILSDDLTDKAEVSEGKAK 642
Query: 290 GAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQK 349
A + P +G G S G ++ + K + +G+ + G K ++
Sbjct: 643 SVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEW 702
Query: 350 AAVVGVKSRKKQRRRG-KKPRRQKASAAGAKSRGGGDKK-GLREAKRRGDGRKKPRWQNP 407
G + +K+R +G +K R Q+ G + G G+++ G RE + +G K +
Sbjct: 703 KKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGE 762
Query: 408 RRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKA-AEAGA 466
++ + G KK R G + G G ++ RG++ + E G
Sbjct: 763 EVEGER----EKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGE 818
Query: 467 ESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQ-KAEAAGEKATAAGAKSRGRKQ 525
G ++ ++ G + G G + G+ G+ K E GE+ G +
Sbjct: 819 VEEGKGEREEEEEEGEGEEEEGEG-EEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGE 877
Query: 526 PRRQKPAVAGAKSRVGGSKSRQ-----RQKAVAAGATSHGGG-GNKQSRGGGGNKPRQWG 579
++ G + G + + ++ G G G G ++ G G + G
Sbjct: 878 GEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEG 937
Query: 580 QTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKD 639
+ G +++ W+ G + G+G ++ + G G ++ G+++
Sbjct: 938 EGEGEDGEGEGEEEEGEWE----GEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEE 993
Query: 640 AAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGD 699
E G G + + E G+E E ++ R + G+
Sbjct: 994 EGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEER--EKEGE 1051
Query: 700 GGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGS-GGAKSRSGKKAAASKS 758
G +N + GK G+ +K +GS K ++ +K + + +
Sbjct: 1052 GEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNT 1111
Query: 759 HGGGGAKRRR 768
G G +R +
Sbjct: 1112 QGNGKEQRSK 1121
Score = 52.8 bits (125), Expect = 1e-06
Identities = 61/319 (19%), Positives = 106/319 (33%), Gaps = 22/319 (6%)
Query: 462 AEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGE-KATAAGAKS 520
AE G E RGD GT G H +G+K + GE + G K
Sbjct: 647 AEDGPEGRGD-----------GTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKE 695
Query: 521 RGRKQPRRQKPAVAGA-KSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWG 579
K+ +++ K R G + + Q+ G HG G ++ G + + G
Sbjct: 696 LAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEG--EEEEGDREEEEEKEG 753
Query: 580 QTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKD 639
+ K G G++ G ++ G K GK+ ++ G ++ RG++
Sbjct: 754 E----GKEEGEGEEVEGEREKEEGERKKEER-AGKEEKGEEEGDQGEGEEEETEGRGEEK 808
Query: 640 AAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGD 699
E G G G ++ ++ E G+ E + + G+
Sbjct: 809 EEGGEVEG--GEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGE 866
Query: 700 GGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSH 759
G + G + + + G G + G G + G G + G+ +
Sbjct: 867 GEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGE 926
Query: 760 GGGGAKRRRGGGAKSRSGE 778
G G G + GE
Sbjct: 927 EGEGEGEEEEGEGEGEDGE 945
Score = 44.3 bits (103), Expect = 5e-04
Identities = 65/376 (17%), Positives = 131/376 (34%), Gaps = 27/376 (7%)
Query: 53 GSGDKKLRRQKAAAGGKKA-RLRGQKGAVAGK-EARQHWQKAAGAGGAENRGGGEQKAAA 110
G K+ R K G ++ + G++ G+ E ++ + G E +G E++
Sbjct: 773 GERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEE 832
Query: 111 AGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQG 170
+ G G + G++ G + + G + G G ++ G +
Sbjct: 833 GEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGE 892
Query: 171 GE-KPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPK 229
GE + ++ G + G+ G + +G+E+ + + E + G+ G + +
Sbjct: 893 GEGEEEEGEGEGEEEGEGEGEEEEG-EGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEE 951
Query: 230 PAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRG---GGDKKLRRQGQNAALA-- 284
+ G G+ ++ G++ G+ G+ G G+++ +G+
Sbjct: 952 EGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEG 1011
Query: 285 -GAKRRGAATAGEKPAAKGRG---GRGPKSLGGQNPRWGRGGKKPRRRGQ------KATK 334
G + GE +G G + G + + G G + R R + K +
Sbjct: 1012 EGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQE 1071
Query: 335 AAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKR 394
+R G + K V K + GK QK S + G + + +
Sbjct: 1072 TGEEENERQDGEEYKK----VSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSK 1127
Query: 395 R----GDGRKKPRWQN 406
R G K W N
Sbjct: 1128 RLLKNGPSGSKKFWNN 1143
Score = 42.4 bits (98), Expect = 0.002
Identities = 70/406 (17%), Positives = 135/406 (33%), Gaps = 28/406 (6%)
Query: 53 GSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAG-GAENRGGGEQKAAAA 111
G G ++ ++ +K +K AGKE + + G G E G GE+K
Sbjct: 753 GEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGG 812
Query: 112 GTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGG 171
+ K R ++ G ++ ++ G + G G G + +G
Sbjct: 813 EVEGGEVEEGKGEREEEEEEGEGEEE-EGEGEEEEGEGEEEEGEG---KGEEEGEEGEGE 868
Query: 172 EKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPA 231
E+ ++ G + + G +E+ +G E G+ G K +
Sbjct: 869 EEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEG 928
Query: 232 AGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGA 291
G + G G+ G+ G+ G+ G +G+ + G
Sbjct: 929 EGEGEEEEGEGE--------GEDGEGEGEEEEGEWEGE-----EEEGEGEGEEEGEGEGE 975
Query: 292 ATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAA 351
GE +G G + + G G ++ G++ + G G G+ +
Sbjct: 976 EGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGE 1035
Query: 352 VVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQ------ 405
+ ++R + + + + + G ++ E R DG + +
Sbjct: 1036 EEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSV 1095
Query: 406 --NPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKK 449
+ QK +G G K+ R + P +K R K+ G KK
Sbjct: 1096 KYGKHKTYQKKSVTNTQGNG-KEQRSKMPVQSK-RLLKNGPSGSKK 1139
>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
Length = 1007
Score = 71.6 bits (174), Expect = 3e-12
Identities = 84/393 (21%), Positives = 156/393 (39%), Gaps = 32/393 (8%)
Query: 97 GAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRA-QKSAAAGSKNRGA 155
G+E G +KA S K + T K+ + R+ +++ K +
Sbjct: 143 GSEEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSKERTRHRSDKKKSK 202
Query: 156 GAQKAAAAAGVKSQGGEK-----PQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREA 210
G + +S+ E+ P K + + ++R K P R R ++K G+ R
Sbjct: 203 GGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLR----RRSQEKIGKARSP 258
Query: 211 KSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGG 270
K + K R+ P ++SR G K RG+ +S+ KS+
Sbjct: 259 TDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKRSE 318
Query: 271 DKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPK--SLGGQNPRWGRGGKKPRRR 328
K ++ ++ + + A++ E + R GR PK SL + R + P
Sbjct: 319 TDKEKKPIKSPS------KDASSGKENRSPSRRPGRSPKRRSLSPKPRDKSRRSRSPLLN 372
Query: 329 GQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPR----------RQKASAAGA 378
+++ ++ + G + K+ + K R+ +RRR PR R+++ A
Sbjct: 373 DRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILSRRERSKDASP 432
Query: 379 KSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSR 438
+R ++ R RR R ++PRRR+ ++P + RG S+ RR ++SR
Sbjct: 433 INRWSPTRRRSRSPIRRRSRSPLRRSRSPRRRS-RSPRRRDRGRRSRSRLRR---RSRSR 488
Query: 439 GGKSRSGGGKKPRRRGQKARQKAAEAGAESRGD 471
GG+ R K + + + + + ES D
Sbjct: 489 GGRRRRSRSKVKEDKFKGSLSEGMKVEQESSSD 521
Score = 48.5 bits (114), Expect = 2e-05
Identities = 98/483 (20%), Positives = 181/483 (37%), Gaps = 85/483 (17%)
Query: 183 KSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGG 242
K + K ++ S D+DKK + + + KKH+R + K
Sbjct: 47 KHKHRSKHKKHKHSSEEDKDKKHKHKH-----------KHKKHKRKEIIDASDKEGMSPA 95
Query: 243 KKPQ----------KQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGA----KR 288
K+ + +++R KA + GK + G L+ + G R
Sbjct: 96 KRTKLDDLALLEDLEKQRALIKAELDNELMEGKVQSGMGLILQGYESGSEEEGEIHEKAR 155
Query: 289 RGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQ 348
G ++ + KG+ + + R ++ R R K K+ GG +
Sbjct: 156 NGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSKERTRHRSDK---------KKSKGGIE 206
Query: 349 KAAVVGVKSRKKQRRRGKKPRRQKASAAGA-----------------KSRGGGDKKGLRE 391
+S+ K+R++ K P ++ S A K+R D K E
Sbjct: 207 IVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKARSPTDDKVKIE 266
Query: 392 AKRRGDGRKK-PRWQNPRRRAQKAPAAKPRG-GGSKKPRRRGPKAAKSRGGKSRSGGGKK 449
K + RKK P R R + + P G K RR K KS+ +S + KK
Sbjct: 267 DKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSK--RSETDKEKK 324
Query: 450 PRRRGQKARQKAAEAGAESRG-DKKQGRQ-KASAAGTKSRGGGLKSHSGKNLWRRGQKAE 507
P K+ K A +G E+R ++ GR K + K R +S S RR ++++
Sbjct: 325 P----IKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKSRRSRSPLLNDRRSKQSK 380
Query: 508 AAGEK-ATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQ 566
+ + AKSR ++ RR+ + R+ ++R R + +++
Sbjct: 381 SPSRTLSPGRRAKSRSLERKRREP-----ERRRLSSPRTRPRDDIL-----------SRR 424
Query: 567 SRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGA 626
R + +W T +++ P +++ + + +SRS ++ R++ G +
Sbjct: 425 ERSKDASPINRWSPTRRRSRS-------PIRRRSRSPLRRSRSPRRRSRSPRRRDRGRRS 477
Query: 627 KSR 629
+SR
Sbjct: 478 RSR 480
Score = 46.2 bits (108), Expect = 1e-04
Identities = 97/498 (19%), Positives = 187/498 (37%), Gaps = 71/498 (14%)
Query: 356 KSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKK------PRWQNPRR 409
+ +KK+ + K ++ K S+ K DKK + K + RK+ +P +
Sbjct: 42 RHKKKKHKHRSKHKKHKHSSEEDK-----DKKHKHKHKHKKHKRKEIIDASDKEGMSPAK 96
Query: 410 RAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESR 469
R + A ++ + + GK +SG G + E+G+E
Sbjct: 97 RTKLDDLALLEDLEKQRALIKAELDNELMEGKVQSGMG---------LILQGYESGSEEE 147
Query: 470 GDKKQGRQKASAAGTKSRG--GGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPR 527
G+ + + + + T+S G L+ K ++ K+ + ++R R +
Sbjct: 148 GEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSK--------ERTRHRSDKK 199
Query: 528 RQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQW----GQTAA 583
+ K + K + SKS++R+K+ + S ++S+ + Q ++
Sbjct: 200 KSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKARSPT 259
Query: 584 AAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKA-----WRQKAAGTGAKSR--------- 629
K + + +K + + +SRS D GKK+ R K+ ++S+
Sbjct: 260 DDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKRSET 319
Query: 630 ---KKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEAR 686
KKP + KDA++ ++ + S ++ KP S + + ++
Sbjct: 320 DKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKSRRSRSPLLNDRRSKQS 379
Query: 687 KKPRR-----RRAKSRGDGGQNAAVGINPWQRRGKKPRLG----------KSRGGGGAKS 731
K P R RRAKSR + P +RR PR +S+
Sbjct: 380 KSPSRTLSPGRRAKSRSLERKRR----EPERRRLSSPRTRPRDDILSRRERSKDASPINR 435
Query: 732 RGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRR-RGGGAKSRSGEKAVTAGGQKAAA 790
+SR +SRS + + S +RR RG ++SR ++ + GG++ +
Sbjct: 436 WSPTRRRSRSPIRRRSRSPLRRSRSPRRRSRSPRRRDRGRRSRSRLRRRSRSRGGRRRRS 495
Query: 791 AGGKKPPRVKSRGGRGQK 808
K + K G K
Sbjct: 496 RSKVKEDKFKGSLSEGMK 513
>gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]
Length = 1464
Score = 70.9 bits (172), Expect = 5e-12
Identities = 215/871 (24%), Positives = 272/871 (31%), Gaps = 115/871 (13%)
Query: 3 YRGHRQCNQAAGRAGPGAPLGAALARTPVELAAESAAPALSAAAAGVKILGSGDKKLRRQ 62
+RG + A G AGP P G +P E A + G R
Sbjct: 267 HRGFSGLDGAKGDAGPAGPKGE--PGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGN 324
Query: 63 KAAAGGK-------KARLRGQKGAVA--GKEARQHWQKAAGAGGAENRGGGEQKAAAAGT 113
A G A G GAV G+ Q + + G G G A AAG
Sbjct: 325 DGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGP 384
Query: 114 KSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGE- 172
G +P +G A + P + + +G Q G K GE
Sbjct: 385 AGNPGADGQPGAKGANGAPGIAGAPGFPGARGP--------SGPQGPGGPPGPKGNSGEP 436
Query: 173 -KPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQRE-AKSRFGKTRGGRRKKHRRPKP 230
P GAK G + G+E K+G + E + G R R P
Sbjct: 437 GAPGSKGDTGAKGEPGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFP 496
Query: 231 AAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRG 290
A G +G + RG G K G++ G+ A L GAK G
Sbjct: 497 GADGVAGPKGPAGE------RGSPGPAGPKGSPGEAGRPGE---------AGLPGAK--G 539
Query: 291 AATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKA 350
+ P G+ GP GQ+ R G G P RGQ A G K G KA
Sbjct: 540 LTGSPGSPGPDGK--TGPPGPAGQDGRPGPPG-PPGARGQ-AGVMGFPGPKGAAGEPGKA 595
Query: 351 AVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRR 410
GV G K AGA+ G A G+ ++ +P +
Sbjct: 596 GERGVPGPP-----GAVGPAGKDGEAGAQGPPG-------PAGPAGERGEQGPAGSPGFQ 643
Query: 411 AQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKK-PRRRG-QKARQKAAEAGAES 468
PA P G + KP +G G S + G + P RG Q A GA
Sbjct: 644 GLPGPAGPP--GEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANG 701
Query: 469 RGDKKQGRQKASAAGTKSRGG--GLKSHSGKN-----LWRRGQKAEAAGEKATAAGAKS- 520
+ A A G G GL+ G+ +G + +A + A + K
Sbjct: 702 APGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDG 761
Query: 521 -RGRKQPRRQKPAVAGAKSRVGGS-KSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQW 578
RG P P AGA G S S A GA G G P
Sbjct: 762 VRGLTGP-IGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGAD 820
Query: 579 GQTAAAAKTRGGGDKQPGWQKAAAGVTK-----SRSGDGGKKAWRQKAAGTGAKS-RKKP 632
GQ A + G K AG G G K R A GA
Sbjct: 821 GQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAA 880
Query: 633 WRRGQKDAAAAEKAWATGATSRGSGGKQPRWQ--------------KPAAAGSESSAAAA 678
R G + + GGK PR + P AG + S A
Sbjct: 881 GRVGPPGPSGNAGPPGPPGPAGKEGGKGPRGETGPAGRPGEVGPPGPPGPAGEKGSPGAD 940
Query: 679 VGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQR--------RGKKPRLGKSRGGGGAK 730
A P +G GQ VG+ P QR G GK G +
Sbjct: 941 GPAGAPGTPGP-------QGIAGQRGVVGL-PGQRGERGFPGLPGPSGEPGKQGPSGASG 992
Query: 731 SRGSGGAKS-RGSGGAKSRSGKKAAASKSHGGGGAKRRRGG-GAKSRSGE--KAVTAGGQ 786
RG G G G SG++ A G G+ R G GAK GE A G
Sbjct: 993 ERGPPGPMGPPGLAGPPGESGREGAP----GAEGSPGRDGSPGAKGDRGETGPAGPPGAP 1048
Query: 787 KAAAAGGKKPPRVKSRGGRGQKAAAGGKKPL 817
A A G P KS G RG+ AG P+
Sbjct: 1049 GAPGAPGPVGPAGKS-GDRGETGPAGPAGPV 1078
Score = 63.5 bits (153), Expect = 7e-10
Identities = 202/841 (24%), Positives = 262/841 (31%), Gaps = 93/841 (11%)
Query: 5 GHRQCNQAAGRAGPGAPLG-AALARTPVELAAESAA----PALSAAAAGVKILGSGDKKL 59
G R + A G AGP P G A P + A+ A P S GV+ G+
Sbjct: 320 GARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGPRGSEGPQGVR----GEPGP 375
Query: 60 RRQKAAAG-GKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGG 118
AAG GQ GA G A G GA G + G K G
Sbjct: 376 PGPAGAAGPAGNPGADGQPGA-KGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSG 434
Query: 119 RGRKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEK----- 173
P +G A G P AG + + GA+ G+ GE+
Sbjct: 435 EPGAPGSKGD-TGAKGEPGPVGVQGPPGPAGEEGK-RGARGEPGPTGLPGPPGERGGPGS 492
Query: 174 ---PQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGK----TRGGRRKKHR 226
P AG K +G++ A +G + GR EA K + G +
Sbjct: 493 RGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGK 552
Query: 227 RPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGA 286
P G R G P + + G G K G+ G++ + G A+ A
Sbjct: 553 TGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGV--PGPPGAVGPA 610
Query: 287 KRRGAATAGEKPAAKGRGG-RGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGG 345
+ G A A P G G RG + G G G P +A K G G
Sbjct: 611 GKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPG--PAGPPGEAGKPGEQGVPGDLG 668
Query: 346 GQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGD-KKGLREAKRRGDGRKKPRW 404
+ G R RG + A GA G D KG A + P
Sbjct: 669 APGPSGARG--ERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGSQGAPGL 726
Query: 405 QNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEA 464
Q A P+G GPK A GK G P A
Sbjct: 727 QGMPGERGAAGLPGPKGDRGDA----GPKGADGSPGKDGVRGLTGPIG-------PPGPA 775
Query: 465 GAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGE-KATAAGAKSRGR 523
GA GDK + A T +RG G + E A AG
Sbjct: 776 GAP--GDKGESGPSGPAGPTGARGAP------------GDRGEPGPPGPAGFAGPPGADG 821
Query: 524 KQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSH-GGGGNKQSRGGGGNKPRQWGQTA 582
+ + +P AGAK G A G + G G K +RG G P G
Sbjct: 822 QPGAKGEPGDAGAKGDAG--PPGPAGPAGPPGPIGNVGAPGAKGARGSAG-PPGATGFPG 878
Query: 583 AAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRK-------KPWRR 635
AA + G P G G GK+ + TG R P
Sbjct: 879 AAGRV---GPPGPSGNAGPPGPP----GPAGKEGGKGPRGETGPAGRPGEVGPPGPPGPA 931
Query: 636 GQKDAAAAE-KAWATGATS-RGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRR 693
G+K + A+ A A G +G G++ P G E G E K+
Sbjct: 932 GEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRG-ERGFPGLPGPSGEPGKQGPSGA 990
Query: 694 AKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKA 753
+ RG G P G G+S G + GS G GS GAK G+
Sbjct: 991 SGERGPPG--------PMGPPGLAGPPGESGREGAPGAEGSPGRD--GSPGAKGDRGETG 1040
Query: 754 AASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAG--GKKPPRVKSRGGRGQKAAA 811
A G G +SG++ T A G G + P +G RG K
Sbjct: 1041 PAGPPGAPGAPGAPGPVGPAGKSGDRGETGPAGPAGPVGPVGARGP-AGPQGPRGDKGET 1099
Query: 812 G 812
G
Sbjct: 1100 G 1100
Score = 62.4 bits (150), Expect = 2e-09
Identities = 188/784 (23%), Positives = 244/784 (31%), Gaps = 103/784 (13%)
Query: 73 LRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAA 132
L G GA G + Q G GA G G G KP R G++
Sbjct: 189 LPGPPGA-PGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPP 247
Query: 133 TGSKKPRWRAQKSAAAGSK-NRGA----GAQKAAAAAGVKSQGGEKPQKAAAA-----GA 182
G + R + G K +RG GA+ A AG K + G + A G
Sbjct: 248 -GPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGL 306
Query: 183 KSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRG-- 240
G+ A +RG++ G A G T P A GAK G
Sbjct: 307 PGERGRPGAPGPAGARGNDGATG----AAGPPGPTGPAGPPGF----PGAVGAKGEAGPQ 358
Query: 241 ---GGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEK 297
G + PQ R G+ G G + G GQ A G A A
Sbjct: 359 GPRGSEGPQGVR--GEPGPPGPAGAAGPAGNPG-----ADGQPGAKGANGAPGIAGAPGF 411
Query: 298 PAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKS 357
P A RG GP+ GG G G+ A G+K G + + VGV+
Sbjct: 412 PGA--RGPSGPQGPGGPPGPKGNSGEP-----------GAPGSKGDTGAKGEPGPVGVQG 458
Query: 358 RKKQR-RRGKKPRRQKASAAGAKS----RGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQ 412
GK+ R + G RGG +G A DG P+ R +
Sbjct: 459 PPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGA----DGVAGPKGPAGERGSP 514
Query: 413 KAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGG--GKK--PRRRGQKARQ-------KA 461
K G + +P G AK G S G GK P GQ R
Sbjct: 515 GPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGAR 574
Query: 462 AEAGAESRGDKKQGRQKASAAGTKSRGG--GLKSHSGKNLWRRGQKAEAAGEKATAAGAK 519
+AG K + AG + G G +GK+ +A A G A A
Sbjct: 575 GQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKD-----GEAGAQGPPGPAGPAG 629
Query: 520 SRGRKQPRRQKPAVAGAKSRVG--GSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQ 577
RG + P P G G G + ++ V + G G + RG G + Q
Sbjct: 630 ERGEQGPAGS-PGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQ 688
Query: 578 WGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQ 637
A + G G K AG + G G + GA P +G
Sbjct: 689 GPPGPAGPRGANGAPGNDG-AKGDAGAPGA-PGSQGAPGLQGMPGERGAAGLPGP--KGD 744
Query: 638 KDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSR 697
+ A + A GS GK G A A G + E+ +R
Sbjct: 745 RGDAGPKGA-------DGSPGKDGVRGLTGPIGPPGPAGAP-GDKGESGPSGPAGPTGAR 796
Query: 698 GDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSR-GSGGAKSRSGKKAAAS 756
G G RG+ G + G + G GAK G GAK +G A
Sbjct: 797 GAPGD-----------RGEPGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAG 845
Query: 757 KSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGG----RGQKAAAG 812
+ G GAK G AAG PP G G G
Sbjct: 846 PAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKEG 905
Query: 813 GKKP 816
GK P
Sbjct: 906 GKGP 909
>gi|239757861 PREDICTED: similar to armadillo repeat containing,
X-linked 4 [Homo sapiens]
Length = 2382
Score = 69.7 bits (169), Expect = 1e-11
Identities = 173/835 (20%), Positives = 290/835 (34%), Gaps = 99/835 (11%)
Query: 9 CNQAAGRAGPGAPLGAALARTPVELAAESAAPALSAAAAGVKILGSGDKKLRRQKAAAGG 68
C++ + ++ GA + A E A+ L A + +GDK A G
Sbjct: 1250 CDETSVKSWAGARAENVVGIGTWARAGEQASGGLWAGGQTSEGTWAGDKA---SGGAWTG 1306
Query: 69 KKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQ 128
+ + G A+AG +A A A GG + G +++GG +
Sbjct: 1307 AENQASGGSWALAGNQAIGELWAAGQASDGSWPGGQASGVSWVGEEAIGGSWTGAENQAS 1366
Query: 129 KAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQ-KAAAAGAKSRSG 187
+ + G+ + A G G+ A +S GG KP+ + A+G S +G
Sbjct: 1367 EGSWAGAGAGNMSSVSYWAGVVDQAGGGSW---AGTSDQSGGGSKPRFEDQASGEGSWAG 1423
Query: 188 KKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKH--RRPKPAAGGAKSRRGGGKKP 245
+ G G ED+ + A + + GG R H + A G + GGG KP
Sbjct: 1424 AGGQASGGSMLGPEDQSSGRSWADTA-DQASGGSRLGHVDQSSGGAWAGTLDQSGGGSKP 1482
Query: 246 QKQRRRGQKAATGGKSRVGKSRGGGDK---KLRRQGQNAALAGAKRRGAATAGEKPAAKG 302
+ + + ++ + G G GGG K + + G++ A +G + G G A G
Sbjct: 1483 RFENQTTEEGSWAG---AGGQAGGGSKVGPEDQSSGRSWANSGDQISGGFLVGIVDQANG 1539
Query: 303 RGGRG---PKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRK 359
G P S+G KP Q + + + A + G + + S
Sbjct: 1540 GSWTGAGHPASVG----------PKPIFEDQVSGRGSWADAREQVVGDSRLGLRDQSSGD 1589
Query: 360 KQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPR-------WQNPRRRAQ 412
G + G+++ GG G + G R P W +P +
Sbjct: 1590 SWAGTGDQASGWFCVCPGSQTNGGS--WGGASGQDVGGSRPGPTNQSSAGSWDSPGSQVS 1647
Query: 413 KA----PAAKPRGGGSKKPRRRGPKAAKS--RGGKSRSGGGKKPRRRGQKARQKAAEAGA 466
+ A + GG KP G ++GGG +P G+
Sbjct: 1648 GSCWTGAGAVDQAGGCSKPGFEDQAIGGGFWPGAGDQTGGGSRP--------------GS 1693
Query: 467 ESRGDKKQGRQKASAAGTKSRGG---GLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGR 523
E D+ G AG + GG G S W G +++G G ++
Sbjct: 1694 E---DQSSGIGSWGVAGGQVLGGARPGPADQSSGGSWA-GTGNQSSGRSWIGPGDQAVDC 1749
Query: 524 KQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGG--GNKPRQWGQT 581
+P + A G GS+ A+G + G ++ GG G++ + G +
Sbjct: 1750 SKPEFEDQACGGGSWAGAGSQ--------ASGESWAGSRPGNEAIGGSRMGSEDQATGGS 1801
Query: 582 AAAAKTRGGGDKQPGWQ-KAAAGVTKSRSGDG--GKKAWRQKAAGTGAKSRKKPWRRGQK 638
A ++ + G Q ++ +A G + G W ++ A ++ K
Sbjct: 1802 WARSEDQASGRFQVSFEVEANEGFWFGPGAEAVIGSWCWTEEKADIVSRPDDKDEATTAS 1861
Query: 639 DAAAAEKAWATG---ATSRGSGGKQPRWQK----------PAAAGSESSAAAAVGQEAEA 685
+ A E+A A ++ S G R ++ A AG+E+ A A G A A
Sbjct: 1862 RSRAGEEAMICSRIEAENKASSGSWIRSEEVAYMGSCVGAEAGAGAEAGAGAEAGAGAGA 1921
Query: 686 RKKPRRRRAKSRGDGGQNAAVGINPWQRRGK--KPRLGKSRGGGG-----AKSRGSGGAK 738
G G ++ A G+ W + RLG G A++ G
Sbjct: 1922 EAGAEAGAGAGAGPGTESGA-GVWSWDGDATTVESRLGAGEEAGVESWTLARNVGEDELS 1980
Query: 739 SRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGG 793
S + S + ++S + + G A SG T+ K AAGG
Sbjct: 1981 RESSPDIEEISLRSLFWAESENSNTFRSKSGKDASFESGAGDNTSIKDKFEAAGG 2035
Score = 60.8 bits (146), Expect = 5e-09
Identities = 176/889 (19%), Positives = 283/889 (31%), Gaps = 160/889 (17%)
Query: 41 ALSAAAAGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAG-GAE 99
A+S A AG+ GS + +A A L G K V G +W + AG G +
Sbjct: 866 AVSKAEAGMGATGSV-----QPQAVANSHCETLPGAKNKVRG-----NWNAVSKAGAGMD 915
Query: 100 NRGGGEQKAAA-------AGTKS-LGGRGRKPRRRGQKAAATGSKKPRWRA--QKSAAAG 149
RG + +A A G K+ + G + G + GS +P+ A Q+ G
Sbjct: 916 TRGSAQPQAVANSQGEVLPGAKNKVKGNPNVVSKAGAREDTVGSTQPQVLASSQRETLPG 975
Query: 150 SKNRGAGAQKAAAAAGVK--SQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGR- 206
++N+ G + AG + + G +PQ A + ++ G + + +G + + + G
Sbjct: 976 ARNKVKGNSNVVSKAGAREDTMGSAQPQVVANSQRETLPGARNKVKGNSNAISKAEAGAG 1035
Query: 207 -----QREAKSRF-GKTRGGRRKKHRRPKPAAGGAKSRRG--GGKKPQKQRRRGQKAATG 258
Q + + F G+ G + K R A A++ G +PQ + G
Sbjct: 1036 IMGSVQVQVVASFQGEVLPGAKNKVRGNSNAVPKAEAGADTVGSAQPQAVANSQSETLLG 1095
Query: 259 GKSRV-------------GKSRGGGDKKLRRQGQNAALAGAKRRGAAT------------ 293
+++V +R ++ Q L GA+ + +T
Sbjct: 1096 ARNKVKGNTIAVPKAGTGAGTRHSAQPQIVAGSQGETLPGARDKSMSTSEAEATAEDEAY 1155
Query: 294 ----AGEKPAAKGRGGRGPKSLGGQNPR-----WGRGGKKPRRRGQK------------- 331
A P ++ GG G ++ P W G + ++
Sbjct: 1156 AKPEAEAMPTSESEGGSGTQACRKTQPNIHDYYWNGIGVEDWIAAERWIKFRFQTMDGDW 1215
Query: 332 ------ATKAAAAGTKRGGGGQQKAAVV---GVKSRKKQRRRGKKPRRQKASAAGAKSRG 382
A A G KA ++ V + + R + G +R
Sbjct: 1216 ENSVSWADDENEASIGSWSGASDKAGIIRSWAVACDETSVKSWAGARAENVVGIGTWARA 1275
Query: 383 GGDKKG-------LREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAA 435
G G E GD W +A A + G +
Sbjct: 1276 GEQASGGLWAGGQTSEGTWAGDKASGGAWTGAENQASGGSWALAGNQAIGELWAAGQASD 1335
Query: 436 KSRGGKSRSG---------GGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKS 486
S G SG GG Q + A AGA + AG S
Sbjct: 1336 GSWPGGQASGVSWVGEEAIGGSWTGAENQASEGSWAGAGAGNMSSVSYWAGVVDQAGGGS 1395
Query: 487 RGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSR 546
G G + R +A G A A G S G ++ G + + G
Sbjct: 1396 WAGTSDQSGGGSKPRFEDQASGEGSWAGAGGQASGG---------SMLGPEDQSSGRSWA 1446
Query: 547 QRQKAVAAGA-------TSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQK 599
+ G+ +S G + GGG+KPR QT G G
Sbjct: 1447 DTADQASGGSRLGHVDQSSGGAWAGTLDQSGGGSKPRFENQTTEEGSWAGAG-------- 1498
Query: 600 AAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGK 659
++G G K G +S + W + + G + +GG
Sbjct: 1499 -------GQAGGGSK-------VGPEDQSSGRSWANSGDQISG---GFLVGIVDQANGGS 1541
Query: 660 QPRWQKPAAAGSE---SSAAAAVGQEAEARKK-----PRRRRAKSRGDGGQNAAVGINPW 711
PA+ G + + G A+AR++ R +S GD + W
Sbjct: 1542 WTGAGHPASVGPKPIFEDQVSGRGSWADAREQVVGDSRLGLRDQSSGDSWAGTGDQASGW 1601
Query: 712 --QRRGKKPRLGKSRGGGGAKSRGS-GGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRR 768
G + G G G GS G ++ S G+ G + + S G GA +
Sbjct: 1602 FCVCPGSQTNGGSWGGASGQDVGGSRPGPTNQSSAGSWDSPGSQVSGS-CWTGAGAVDQA 1660
Query: 769 GGGAKSRSGEKAVTAG---GQKAAAAGGKKPPRVKSRGGRGQKAAAGGK 814
GG +K ++A+ G G GG +P G G AGG+
Sbjct: 1661 GGCSKPGFEDQAIGGGFWPGAGDQTGGGSRPGSEDQSSGIGSWGVAGGQ 1709
Score = 52.8 bits (125), Expect = 1e-06
Identities = 200/878 (22%), Positives = 289/878 (32%), Gaps = 164/878 (18%)
Query: 70 KARLRGQKGAV----AGKEAR-QHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPR 124
K ++RG + AG + + Q ++ G RG KA A K G G +
Sbjct: 581 KIKVRGNVNTMPKEGAGVDMKAQGMAQSQGEALPNTRGKARGKAKA---KCKTGPGMDMK 637
Query: 125 RRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGG--------EKPQK 176
Q A G K P A S+ G G A + AG K+ PQ
Sbjct: 638 TCTQPQA--GVKTPA-----EALLDSRVDGRGNPNATSKAGTKADQRVCGQPLVVANPQG 690
Query: 177 AAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRF-GKTRGGRRKKHRRPKPAAGGA 235
A GAK++ P G+ Q EA F G+ G + K + A
Sbjct: 691 EALPGAKNKVKGNPHTVLKVGAGEGTTDSAQPEAVVSFQGEALLGTKNKVKGNPNVVLKA 750
Query: 236 KSRRGGGKKPQKQRRRGQKAAT---------GGKSRVGKSRGGGDK------KLRRQGQN 280
+ G Q Q K G + V K+ G D ++ Q
Sbjct: 751 EVGEGAMGTAQLQIMASSKGEALLDSKNKVKGNSNAVSKAGAGTDTTGSVQPQIVANSQG 810
Query: 281 AALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGR--------GGKKPRRRGQKA 332
L GAK + P G GP + P+ G K + A
Sbjct: 811 EVLPGAKNKIRGN----PTTVPNSGVGPYTTDSARPQAVANSQGEVLPGAKNKVKANLNA 866
Query: 333 TKAAAAGTKRGGGGQQKAAVVG---VKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGL 389
A AG G Q +A K + RG KA A G +RG + +
Sbjct: 867 VSKAEAGMGATGSVQPQAVANSHCETLPGAKNKVRGNWNAVSKAGA-GMDTRGSAQPQAV 925
Query: 390 REAKRRGD---GRKKPRWQNPRRRAQKAPAAKPRGGGSK------KPRRRGPKAAKSRGG 440
A +G+ G K NP KA A + G ++ R P A G
Sbjct: 926 --ANSQGEVLPGAKNKVKGNPNV-VSKAGAREDTVGSTQPQVLASSQRETLPGARNKVKG 982
Query: 441 KSR--SGGGKKPRRRGQKARQKAAEAGAESR-GDKKQGRQKASAAGTKSRGGGLK----- 492
S S G + G Q A + E+ G + + + ++A G G+
Sbjct: 983 NSNVVSKAGAREDTMGSAQPQVVANSQRETLPGARNKVKGNSNAISKAEAGAGIMGSVQV 1042
Query: 493 ----SHSGKNLWRRGQKAEAAGEKATA----AGAKSRGRKQPRR----QKPAVAGAKSRV 540
S G+ L G K + G AGA + G QP+ Q + GA+++V
Sbjct: 1043 QVVASFQGEVL--PGAKNKVRGNSNAVPKAEAGADTVGSAQPQAVANSQSETLLGARNKV 1100
Query: 541 GGSKSRQRQKAVAAGATSHGG------GGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQ 594
G+ + AG T H G ++ G +K + A A+ D+
Sbjct: 1101 KGNTIAVPKAGTGAG-TRHSAQPQIVAGSQGETLPGARDKSMSTSEAEATAE-----DEA 1154
Query: 595 PGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRR-GQKDAAAAEKAWATGA-- 651
+A A T G G +A R+ T W G +D AAE+ W
Sbjct: 1155 YAKPEAEAMPTSESEGGSGTQACRK----TQPNIHDYYWNGIGVEDWIAAER-WIKFRFQ 1209
Query: 652 TSRGSGGKQPRW---QKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGI 708
T G W + A+ GS S A+ G KS VGI
Sbjct: 1210 TMDGDWENSVSWADDENEASIGSWSGASDKAGIIRSWAVACDETSVKSWAGARAENVVGI 1269
Query: 709 NPWQRRGKKPRLGKSRGG-------GGAKSRGSG--GAKSRGSGGAKSRSGKKA------ 753
W R G++ G GG G K+ G GA+++ SGG+ + +G +A
Sbjct: 1270 GTWARAGEQASGGLWAGGQTSEGTWAGDKASGGAWTGAENQASGGSWALAGNQAIGELWA 1329
Query: 754 ---AASKSHGGG------------------GAKRRRGGGAKSRSGEKAVT---------- 782
A+ S GG GA+ + G+ + +G ++
Sbjct: 1330 AGQASDGSWPGGQASGVSWVGEEAIGGSWTGAENQASEGSWAGAGAGNMSSVSYWAGVVD 1389
Query: 783 -AGGQKAA-----AAGGKKPPRVKSRGGRGQKAAAGGK 814
AGG A + GG KP G G A AGG+
Sbjct: 1390 QAGGGSWAGTSDQSGGGSKPRFEDQASGEGSWAGAGGQ 1427
Score = 46.6 bits (109), Expect = 9e-05
Identities = 194/890 (21%), Positives = 309/890 (34%), Gaps = 161/890 (18%)
Query: 39 APALSAAAAGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEAR-QHWQKAAGAG- 96
A + A G KI G+ + A +A ++ Q VA K+A + G G
Sbjct: 418 AKTQTEAIPGAKIDAGGNTNAMCKVGAGADVRACIQPQ--TVAKKQAEVTSGARVDGRGN 475
Query: 97 ---------GAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQ-----KAAATGSKKPRWRA 142
GA+ R + +A A+ T + K + RG KA A + + +
Sbjct: 476 TNVISKAITGADMRAAAQPQAVAS-THAEAMSDAKVKNRGNPNAMTKAGAKANLRANSQV 534
Query: 143 QKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRG-----AKS 197
+ A K+RG A G +PQ A+ A + S K + RG K
Sbjct: 535 EALPDARDKSRGNPNVMAKVGDGTDMLSCTQPQLVASVQADTLSDGKIKVRGNVNTMPKE 594
Query: 198 RGDEDKK--GRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSR-----RGGGKKPQKQRR 250
D K G + TRG R K + G + + G K P +
Sbjct: 595 GAGVDMKAQGMAQSQGEALPNTRGKARGKAKAKCKTGPGMDMKTCTQPQAGVKTPAEALL 654
Query: 251 RGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKG------RG 304
+ G + K+ D+++ Q L A +G A G K KG +
Sbjct: 655 DSRVDGRGNPNATSKAGTKADQRVCGQ----PLVVANPQGEALPGAKNKVKGNPHTVLKV 710
Query: 305 GRGPKSLGGQNPR-----WGRG--GKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKS 357
G G + P G G K + +G A + G G A + + S
Sbjct: 711 GAGEGTTDSAQPEAVVSFQGEALLGTKNKVKGNPNVVLKA---EVGEGAMGTAQLQIMAS 767
Query: 358 RKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAK--RRGDGRKKPRWQNPRRRAQKAP 415
K + K + + S A +K+ G D G + + G P +N + + P
Sbjct: 768 SKGEALLDSKNKVKGNSNAVSKAGAGTDTTGSVQPQIVANSQGEVLPGAKN---KIRGNP 824
Query: 416 AAKPRGG-GSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRG---- 470
P G G P+A + G+ G K + + AEAG + G
Sbjct: 825 TTVPNSGVGPYTTDSARPQAVANSQGEVLPGAKNKVKANLNAVSK--AEAGMGATGSVQP 882
Query: 471 ---------------DKKQGRQKA---SAAGTKSRGG----GLKSHSGKNLWRRGQKAEA 508
+K +G A + AG +RG + + G+ L K +
Sbjct: 883 QAVANSHCETLPGAKNKVRGNWNAVSKAGAGMDTRGSAQPQAVANSQGEVLPGAKNKVKG 942
Query: 509 AGEKATAAGAK--SRGRKQPR----RQKPAVAGAKSRVGG-----SKSRQRQKAVAAGAT 557
+ AGA+ + G QP+ Q+ + GA+++V G SK+ R+ + +
Sbjct: 943 NPNVVSKAGAREDTVGSTQPQVLASSQRETLPGARNKVKGNSNVVSKAGAREDTMGSAQP 1002
Query: 558 SHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGG----------------GDKQPGWQKAA 601
+++ G NK + G + A +K G G+ PG +
Sbjct: 1003 QVVANSQRETLPGARNKVK--GNSNAISKAEAGAGIMGSVQVQVVASFQGEVLPGAKNKV 1060
Query: 602 AG----VTKSRSG-DGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGS 656
G V K+ +G D A Q A + +++ + + + A KA TGA +R S
Sbjct: 1061 RGNSNAVPKAEAGADTVGSAQPQAVANSQSETLLGARNKVKGNTIAVPKA-GTGAGTRHS 1119
Query: 657 ------GGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRR---RAKSRGDGGQNA--- 704
G Q A S S++ A E EA KP ++S G G A
Sbjct: 1120 AQPQIVAGSQGETLPGARDKSMSTSEAEATAEDEAYAKPEAEAMPTSESEGGSGTQACRK 1179
Query: 705 -----------AVGINPW--QRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGK 751
+G+ W R K R ++ G S ++ S G+ S +
Sbjct: 1180 TQPNIHDYYWNGIGVEDWIAAERWIKFRF-QTMDGDWENSVSWADDENEASIGSWSGASD 1238
Query: 752 KA------------AASKSHGGGGAKRRRGGGAKSRSGEKA---VTAGGQ 786
KA + KS G A+ G G +R+GE+A + AGGQ
Sbjct: 1239 KAGIIRSWAVACDETSVKSWAGARAENVVGIGTWARAGEQASGGLWAGGQ 1288
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 69.7 bits (169), Expect = 1e-11
Identities = 122/590 (20%), Positives = 218/590 (36%), Gaps = 104/590 (17%)
Query: 167 KSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDE---DKKGRQREAKSRFGKTRGGRRK 223
+ +G + K A + R+ +K R R + R E D+K +R K R K R +
Sbjct: 38 RRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRER 97
Query: 224 KHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAAL 283
+ R K R ++ ++ R++ ++ T + G+ R ++ R + ++A
Sbjct: 98 QRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAE- 156
Query: 284 AGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRG 343
K R T E+ R + K + R R ++ R+ +K K ++RG
Sbjct: 157 ---KERERQTDRERQRQTERNRQ--KEREREKNRQER--RERERQREKENKTEDRHSERG 209
Query: 344 GGGQQKAAVVGVKSRKKQ------------RRRGKKPRRQKASAAGAKSRGGGDKKGLRE 391
+++ RK+Q R R K+ R++AS ++ +++ R+
Sbjct: 210 RERERERETETETERKRQTDRERDRQRKTEREREKQAERERASER--ETERDKERERERD 267
Query: 392 AKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPR 451
R D R+K R + R+ Q+ + R K+ R+R + + R K ++
Sbjct: 268 RDRDRDRRQKERERQTDRKRQRR-TERDRETERKRERQRERERERERNRKRE----RERE 322
Query: 452 RRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGE 511
R ++ RQ+ E E ++K+ RQ + G G+ R ++ E +
Sbjct: 323 RERERERQRETERDREKERERKRKRQTEMDRERNRQTG----REGRRQAERERERERERD 378
Query: 512 KATAAGAKSRGRKQPR-RQKPAVAGAKSRVGGS----KSRQRQKAVAAGATSHGGGGNKQ 566
+ +A + R R + R RQK + G K R+R+K + G ++
Sbjct: 379 RQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREK 438
Query: 567 SRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGA 626
+G ++ RQ + A + R P + A +GV +S
Sbjct: 439 QKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQS---------------DPNR 483
Query: 627 KSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEAR 686
+R W+ +D AA + W +PA A + R
Sbjct: 484 PTRGIRWKSSPEDPKAASTRFP--------------WGRPAKA-------------SRGR 516
Query: 687 KKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKSRGSGG 736
RRR W+ PRLG+ RG GG R SGG
Sbjct: 517 VAGRRR------------------WE-----PRLGEKRGQGGEGRRPSGG 543
Score = 57.4 bits (137), Expect = 5e-08
Identities = 93/523 (17%), Positives = 201/523 (38%), Gaps = 66/523 (12%)
Query: 121 RKPRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAA 180
RK RR +K K+ R R ++ + R ++ +++ E+ ++
Sbjct: 77 RKRERRREKDRHR--KRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETERE 134
Query: 181 GAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRG 240
G + R + +R + + D +K+ ++ + R +T R+K+ R K + RR
Sbjct: 135 GERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREK----NRQERRE 190
Query: 241 GGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAA 300
++ +K+ + + + G+ R + + + +RQ ++R EK A
Sbjct: 191 RERQREKENKTEDRHSERGRERERERETETETERKRQTDRER---DRQRKTEREREKQAE 247
Query: 301 KGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKK 360
+ R R ++ R R + + R+K
Sbjct: 248 RERASERETE---------RDKERERERDRDRDR---------------------DRRQK 277
Query: 361 QRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPR 420
+R R +RQ+ + ++ +++ RE +R + +++ + R R ++ + R
Sbjct: 278 ERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDR 337
Query: 421 GGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQK---AAEAGAESRGDKKQGRQ 477
++ R+R + + R ++ G ++ R ++ R++ +A E D+ + RQ
Sbjct: 338 EKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQ 397
Query: 478 KASAAGT-KSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPR-RQKPAVAG 535
K T K R G + + K R + G + K +GR++ R RQ AG
Sbjct: 398 KERERQTEKDRDG--QRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAG 455
Query: 536 AKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRG----GGGNKPR------QWGQTAAAA 585
+ + + +G N+ +RG P+ WG+ A A+
Sbjct: 456 RQRKRSTLYVNPPPRTARSGVVQ--SDPNRPTRGIRWKSSPEDPKAASTRFPWGRPAKAS 513
Query: 586 KTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKS 628
+ R G ++ W+ G + + G+G R+ + G G ++
Sbjct: 514 RGRVAGRRR--WE-PRLGEKRGQGGEG-----RRPSGGFGTEN 548
Score = 50.4 bits (119), Expect = 6e-06
Identities = 109/616 (17%), Positives = 227/616 (36%), Gaps = 85/616 (13%)
Query: 186 SGKKPRRRGA-----KSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRG 240
S + PRRRG + GD+ ++ RQ+E + R K + R +R + +R
Sbjct: 33 SQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRD 92
Query: 241 GGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAA 300
++ Q+ R + ++ T D++ RQ + K R E+
Sbjct: 93 RHRERQRDREKERERQT-------------DRERDRQRE-------KERNRQKERERETE 132
Query: 301 K-GRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRK 359
+ G GR ++ G + R +K R R + + T+R +++ + R+
Sbjct: 133 REGERGRDRQTDGQRERERQRDAEKERER--QTDRERQRQTERNRQKEREREKNRQERRE 190
Query: 360 KQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKP 419
++R+R K+ + + + + R + ++R R++ R + R +K A +
Sbjct: 191 RERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQ-AERE 249
Query: 420 RGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKA 479
R + R + + + R + R K+ R+ + RQ+ E E+ +++ R++
Sbjct: 250 RASERETERDKERERERDRD-RDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERE 308
Query: 480 SAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSR 539
+ + K R ++ E ++ T R R++ R +K K +
Sbjct: 309 RE----------RERNRKRERERERERERERQRET-----ERDREKERERK-----RKRQ 348
Query: 540 VGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQK 599
+ R RQ G G +Q+ + R+ + +A + D+ QK
Sbjct: 349 TEMDRERNRQT---------GREGRRQAERER-ERERERDRQSAREREERERDRDRDRQK 398
Query: 600 AAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGK 659
T+ + DG ++ +Q+ +S + R +++ + T R +G +
Sbjct: 399 ERERQTE-KDRDGQRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQ 457
Query: 660 QPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVGINPWQRRGKKPR 719
+ R ++ + V +++ + R R KS + + A+ PW R K
Sbjct: 458 RKRSTLYVNPPPRTARSGVV--QSDPNRPTRGIRWKSSPEDPKAASTRF-PWGRPAKA-- 512
Query: 720 LGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEK 779
SRG + R + + GG G + G G ++ +
Sbjct: 513 -------------------SRGRVAGRRRWEPRLGEKRGQGGEGRRPSGGFGTENPLSQA 553
Query: 780 AVTAGGQKAAAAGGKK 795
G + GK+
Sbjct: 554 PSVFPGPRYTPGDGKR 569
Score = 45.1 bits (105), Expect = 3e-04
Identities = 49/204 (24%), Positives = 84/204 (41%), Gaps = 15/204 (7%)
Query: 119 RGRKPRRRGQKAAATGSKKPRWRAQKSAAAGS---KNRGAGAQKAAAAAGVKSQGGEKPQ 175
R R+ R G++ A ++ R R ++SA ++R QK K + G++
Sbjct: 355 RNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRET 414
Query: 176 KAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKK---HRRPKPAA 232
+ K R ++ R RG R E +KGR+R+ + + + G +RK+ + P P
Sbjct: 415 EKQREREKDRESERGRERG---REREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRT 471
Query: 233 GGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAA 292
+ + +P + R + + K+ + G K R +AG +RR
Sbjct: 472 ARSGVVQSDPNRPTRGIR-WKSSPEDPKAASTRFPWGRPAKASR----GRVAG-RRRWEP 525
Query: 293 TAGEKPAAKGRGGRGPKSLGGQNP 316
GEK G G R G +NP
Sbjct: 526 RLGEKRGQGGEGRRPSGGFGTENP 549
Score = 37.0 bits (84), Expect = 0.074
Identities = 86/469 (18%), Positives = 167/469 (35%), Gaps = 46/469 (9%)
Query: 361 QRRRGKK--PRRQKASAAGAKSRGGGDKKGLR--EAKRRGDGRKKPRWQNPRRRAQKAPA 416
+RR G + PRR+ A K G D++ R E +RR + R+ R + R+R ++
Sbjct: 28 RRRPGSQESPRRRGLGQAH-KDADGDDRERNRQKERERRREKRQTER-ETDRKRERRREK 85
Query: 417 AKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGR 476
+ R K+ R R + + + + ++ + +R ++ RQK E E G++ + R
Sbjct: 86 DRHR----KRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDR 141
Query: 477 QKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGA 536
Q + + K + R ++ E +K + R++ RQ+
Sbjct: 142 QTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKT 201
Query: 537 KSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPG 596
+ R + R+R++ + ++ R + RQ KT +KQ
Sbjct: 202 EDR-HSERGRERERERETETET------ERKRQTDRERDRQ-------RKTEREREKQAE 247
Query: 597 WQKAAAGVT-----KSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGA 651
++A+ T + R D + R++ RK+ RR ++D K
Sbjct: 248 RERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQ-RRTERDRETERKRERQRE 306
Query: 652 TSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRR-----RAKSRGDGGQNAAV 706
R + R ++ + R++ R+R R ++R G +
Sbjct: 307 RERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQ 366
Query: 707 GINPWQRRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSG-----------KKAAA 755
+R ++ R + R K R K R G K +
Sbjct: 367 AERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRES 426
Query: 756 SKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGG 804
+ G + ++ G + R + AG Q+ + PP +R G
Sbjct: 427 ERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSG 475
>gi|239750574 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1297
Score = 69.3 bits (168), Expect = 1e-11
Identities = 212/852 (24%), Positives = 282/852 (33%), Gaps = 141/852 (16%)
Query: 4 RGHRQCNQAAGRAGPGAPLGAALARTPVELAAESAAPALSAAAAGVKILGSGDKKLRRQK 63
RGH R G G LG A P+ + A+ AA GV+ L + L +
Sbjct: 263 RGH-----GGDRRGGGEGLGTVAAAAPLRVCADDLG-----AAVGVRGLAGLQEGLDSRH 312
Query: 64 AAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKA-------------AA 110
+ R + G A W + G RGGG K+ A
Sbjct: 313 LLHEAQPLHARRRAG-----HAGSFWLR--GGRDRLRRGGGHTKSHLGVVTIVPGRRGRA 365
Query: 111 AGTKSLGGRGRKPR--RRGQKAAATGSKKPRWRAQKSAAAGSKN-RGAGAQKAAAAAGVK 167
AG + GGRGR+ + RRG++ A G K AG+ R A AG
Sbjct: 366 AGGQERGGRGRRRQQGRRGRRQAGPGLAK----VDVDVLAGALGLRWQWVLVHAGQAGQP 421
Query: 168 SQGGEK-PQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRF-GKTRGGRRKKH 225
QG + P + AA ++ R G + +G E R G RG R +
Sbjct: 422 LQGQARGPHRPAALAQEALRAAAARPHGRRHYRVRGLRGAGPEGAGRLAGPWRGLRLQTL 481
Query: 226 RRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAG 285
GGA + ATG VG G G QG AA
Sbjct: 482 LLQDAPHGGAH-----------EHVLVAVPATG----VGGLVGAG------QGAVAAAGN 520
Query: 286 AKRR---GAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKP--RRRGQKATKAAA-AG 339
A R G GE+ GRG RG + GG G + GQ T A
Sbjct: 521 APERLPAGVQGCGEEV---GRGARGDRVAGGHVEVVPVGQQLAICMLHGQLGTAPHAHVP 577
Query: 340 TKRGGGGQQKAAVVGVKSRKK---QRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRG 396
T GG +A +V +R++ +RR G PRR + G GGG GL++ G
Sbjct: 578 TVLGGALGGRAGLVAAPARRECPARRRGGCWPRRPRRRHGGG---GGGGGPGLQDLLGGG 634
Query: 397 DGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQK 456
APAA + R G A + G
Sbjct: 635 HAG------GAHGHVVVAPAAAAPTAREGRAGRHGHVAVVC---PQVAAGAPVGADLDVS 685
Query: 457 ARQKAAEAGAESRGDKKQGRQKASAAGTKS---------RGGGLKSHSGKNLWRRGQKAE 507
G RG + GR +A+ A + RG G H WR
Sbjct: 686 VVLWVGVVGHLGRG-RGAGRAEAARAAREGGPHQGVFIQRGRGGLGHRPLPGWRGQGVGP 744
Query: 508 AAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQS 567
A G R PAV A G + AA A S G G +
Sbjct: 745 LAQPSVQVLGRVPRD--------PAVGAATVAQGPVHGHVPVELTAAAAVS-GRGRLRDG 795
Query: 568 RGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAK 627
G + + Q A A G + AGV G GG A A +
Sbjct: 796 LGRVASVAAEGAQVAWAGAVLVQGHE--------AGVAGGARG-GGAAAGGPLAGAVVQR 846
Query: 628 SRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEARK 687
R++ R G++ A A A G G+GG R + G AAV Q A R+
Sbjct: 847 MRQRRVRAGRRRVGARAVA-AAGRQGAGAGGGGRRVRHGHGHG------AAVLQRAPCRQ 899
Query: 688 KPRRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGGAKS-RGSGGAKSRGSGGAK 746
+ A + AA G+ Q R +P G GA S R GA+ R
Sbjct: 900 QRHLAPAAAAA-----AAQGVRAAQGRAHRP------GAQGAPSHRHRPGARGR------ 942
Query: 747 SRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGRG 806
RS ++AA + + GGA R + R G +AV A A G + +V G
Sbjct: 943 -RSRRRAAVALA---GGAHPARAALGRRRGGGQAVGARAAHQARLAGGQVDQVVVAARAG 998
Query: 807 QKAAAGGKKPLR 818
G++P R
Sbjct: 999 DADGVRGRRPRR 1010
Score = 63.5 bits (153), Expect = 7e-10
Identities = 87/328 (26%), Positives = 118/328 (35%), Gaps = 26/328 (7%)
Query: 68 GKKARLRGQKGAVAGKEARQHWQKAA-----GAGGAENR---GGGEQKAAAAGTKSLGGR 119
G R RG A A + AR+ G GG +R G Q S+
Sbjct: 694 GHLGRGRGAGRAEAARAAREGGPHQGVFIQRGRGGLGHRPLPGWRGQGVGPLAQPSVQVL 753
Query: 120 GRKPRRRGQKAA--ATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKA 177
GR PR AA A G + +AAA RG A V ++G +
Sbjct: 754 GRVPRDPAVGAATVAQGPVHGHVPVELTAAAAVSGRGRLRDGLGRVASVAAEGAQVAWAG 813
Query: 178 AAAGAKSRSGKKPRRRGAKSRGDEDKKG----RQREAKSRFGKTRGGRRKKHRRPKPAAG 233
A +G RG + G R R+ + R G+ R G R + AG
Sbjct: 814 AVLVQGHEAGVAGGARGGGAAAGGPLAGAVVQRMRQRRVRAGRRRVGARAVAAAGRQGAG 873
Query: 234 GAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAAT 293
GGG++ + G R + QG AA A R GA
Sbjct: 874 AG----GGGRRVRHGHGHGAAVLQRAPCRQQRHLAPAAAAAAAQGVRAAQGRAHRPGAQG 929
Query: 294 AGE---KPAAKGRGGRGPKSL---GGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQ 347
A +P A+GR R ++ GG +P G+ RR G +A A AA R GGQ
Sbjct: 930 APSHRHRPGARGRRSRRRAAVALAGGAHPARAALGR--RRGGGQAVGARAAHQARLAGGQ 987
Query: 348 QKAAVVGVKSRKKQRRRGKKPRRQKASA 375
VV ++ RG++PRR +A
Sbjct: 988 VDQVVVAARAGDADGVRGRRPRRLALTA 1015
Score = 59.3 bits (142), Expect = 1e-08
Identities = 200/848 (23%), Positives = 279/848 (32%), Gaps = 140/848 (16%)
Query: 44 AAAAGVKILGSGDKKLRRQKAAAGGKKARLRGQKGAVAGKEARQHWQKAAGAGGAENRGG 103
A AAG S D+ A G +RLR ++ + R WQ G + G
Sbjct: 120 APAAGAADAHSADETPEASGPAPGALVSRLRKRRR----RRLRLGWQP----GLLPHVDG 171
Query: 104 GEQKAAAAGTKSLGGRGRK--PRRRGQKAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAA 161
+ + L GR PR Q T +P R Q+ + G G A
Sbjct: 172 DVVETILEAGRGLSAHGRSTAPRTTDQAPGLTRGPRPALRCQRGRRL-QLSWGGGRLVAP 230
Query: 162 AAAGVKSQGGEKPQKAAAAGAK---------SRSGKKPRRRGAKSRGDEDKKGRQREAKS 212
+ A + P++ G + R RR G + G R
Sbjct: 231 SRADTHAALAAFPERDIFHGGRVVALGVVGEGRGHGGDRRGGGEGLGTVAAAAPLRVCAD 290
Query: 213 RFGKTRGGRRKKHRRPKPAAGGAKSRRGGGK-KPQKQRRRGQKAAT----GGKSRVGKSR 267
G G R + G SR + +P RRR A + GG+ R+ R
Sbjct: 291 DLGAAVGVRGLAGLQE-----GLDSRHLLHEAQPLHARRRAGHAGSFWLRGGRDRL--RR 343
Query: 268 GGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRR 327
GGG K G + G RRG A G++ RGGRG + G+ R R+
Sbjct: 344 GGGHTK-SHLGVVTIVPG--RRGRAAGGQE-----RGGRGRRRQQGRRGR--------RQ 387
Query: 328 RGQKATK------AAAAGTKRGG----GGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAG 377
G K A A G + GQ + G ++R R +A+AA
Sbjct: 388 AGPGLAKVDVDVLAGALGLRWQWVLVHAGQAGQPLQG-QARGPHRPAALAQEALRAAAAR 446
Query: 378 AKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKS 437
R +GLR A G GR W+ R + A P GG + P A
Sbjct: 447 PHGRRHYRVRGLRGAGPEGAGRLAGPWRGLRLQTLLLQDA-PHGGAHEHVLVAVP--ATG 503
Query: 438 RGGKSRSG------GGKKPRRRGQKARQKAAEAGAESRGDKKQG---------RQKASAA 482
GG +G G P R + E G +RGD+ G +Q A
Sbjct: 504 VGGLVGAGQGAVAAAGNAPERLPAGVQGCGEEVGRGARGDRVAGGHVEVVPVGQQLAICM 563
Query: 483 GTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGG 542
G +H L A G +A A +R R+ P R++ GG
Sbjct: 564 LHGQLGTAPHAHVPTVL------GGALGGRAGLVAAPAR-RECPARRR----------GG 606
Query: 543 SKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQT-----AAAAKTRGGGDKQPGW 597
R+ ++ G GGG Q GGG+ G AAA R G + G
Sbjct: 607 CWPRRPRRRHGGGGG--GGGPGLQDLLGGGHAGGAHGHVVVAPAAAAPTAREGRAGRHGH 664
Query: 598 -----QKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGA- 651
+ AAG D W G R + R + AA E G
Sbjct: 665 VAVVCPQVAAGAPVGADLDVSVVLW---VGVVGHLGRGRGAGRAEAARAAREGGPHQGVF 721
Query: 652 TSRGSGG----KQPRWQKPAAAGSESSAAAAVGQEAEARKKPRRRRAKSRGDGGQNAAVG 707
RG GG P W+ + +G+ R A Q G
Sbjct: 722 IQRGRGGLGHRPLPGWRGQGVGPLAQPSVQVLGRVP-------RDPAVGAATVAQGPVHG 774
Query: 708 INPWQRRGKKPRLGKSR---GGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGA 764
P + G+ R G G S + GA+ +G + + A + GGG A
Sbjct: 775 HVPVELTAAAAVSGRGRLRDGLGRVASVAAEGAQVAWAGAVLVQGHEAGVAGGARGGGAA 834
Query: 765 -------------KRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGRGQKAAA 811
++RR + R G +AV A G++ A AGG + R G G AA
Sbjct: 835 AGGPLAGAVVQRMRQRRVRAGRRRVGARAVAAAGRQGAGAGGGGR---RVRHGHGHGAAV 891
Query: 812 GGKKPLRR 819
+ P R+
Sbjct: 892 LQRAPCRQ 899
Score = 53.1 bits (126), Expect = 1e-06
Identities = 97/390 (24%), Positives = 133/390 (34%), Gaps = 79/390 (20%)
Query: 94 GAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQ---KSAAAGS 150
G G RG G +A AA GG + + + P WR Q A
Sbjct: 691 GVVGHLGRGRGAGRAEAARAAREGGPHQGVFIQRGRGGLGHRPLPGWRGQGVGPLAQPSV 750
Query: 151 KNRGAGAQKAAAAAGVKSQG---GEKPQKAAAAGAKSRSGKKPRRRGAKSRGDEDKKGRQ 207
+ G + A A +QG G P + AA A S +GR
Sbjct: 751 QVLGRVPRDPAVGAATVAQGPVHGHVPVELTAAAAVSG------------------RGRL 792
Query: 208 REAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSR 267
R+ R AA GA+ G Q G +A G +R G +
Sbjct: 793 RDGLGRVASV-------------AAEGAQVAWAGAVLVQ-----GHEAGVAGGARGGGAA 834
Query: 268 GGGDKK---LRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGG-- 322
GG ++R Q AG +R GA AA GR G G GG+ R G G
Sbjct: 835 AGGPLAGAVVQRMRQRRVRAGRRRVGARAV----AAAGRQGAGAGG-GGRRVRHGHGHGA 889
Query: 323 --------KKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKS-RKKQRRRGKKPRRQKA 373
++ R A AAA G + G + G S R + RG++ RR+ A
Sbjct: 890 AVLQRAPCRQQRHLAPAAAAAAAQGVRAAQGRAHRPGAQGAPSHRHRPGARGRRSRRRAA 949
Query: 374 SAAGAKSRGGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPK 433
A GG +RRG G+ A+ A A+ GG +
Sbjct: 950 VALA----GGAHPARAALGRRRGGGQAV--------GARAAHQARLAGG------QVDQV 991
Query: 434 AAKSRGGKSRSGGGKKPRRRGQKARQKAAE 463
+R G + G++PRR AR + E
Sbjct: 992 VVAARAGDADGVRGRRPRRLALTARPELEE 1021
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.125 0.361
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,764,842
Number of Sequences: 37866
Number of extensions: 2105706
Number of successful extensions: 39594
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 451
Number of HSP's successfully gapped in prelim test: 1413
Number of HSP's that attempted gapping in prelim test: 15224
Number of HSP's gapped (non-prelim): 13641
length of query: 819
length of database: 18,247,518
effective HSP length: 111
effective length of query: 708
effective length of database: 14,044,392
effective search space: 9943429536
effective search space used: 9943429536
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.