Search of human proteins with 239745643

Search of human proteins with 239745643

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform
1 [Homo sapiens]
         (558 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1...  1105   0.0  
gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6...  1090   0.0  
gi|239756672 PREDICTED: hypothetical protein LOC146429 [Homo sap...   877   0.0  
gi|63999576 solute carrier family 22, member 17 isoform b [Homo ...   283   2e-76
gi|21361834 solute carrier family 22, member 17 isoform a [Homo ...   270   2e-72
gi|170650643 solute carrier family 22, member 23 isoform a [Homo...   260   3e-69
gi|48526516 solute carrier family 22, member 23 isoform b [Homo ...   208   1e-53
gi|4507005 solute carrier family 22 member 5 [Homo sapiens]           150   3e-36
gi|4507001 solute carrier family 22 member 2 [Homo sapiens]           141   1e-33
gi|11415038 solute carrier family 22 member 3 [Homo sapiens]          138   1e-32
gi|24497499 solute carrier family 22 member 8 [Homo sapiens]          137   2e-32
gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]          137   3e-32
gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa...   136   4e-32
gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa...   136   6e-32
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap...   130   3e-30
gi|24497490 solute carrier family 22 member 4 [Homo sapiens]          127   2e-29
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa...   124   2e-28
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa...   122   7e-28
gi|166064021 solute carrier family 22 (organic anion transporter...   121   2e-27
gi|238814326 solute carrier family 22, member 20 [Homo sapiens]       111   2e-24
gi|31542327 solute carrier family 22, member 16 [Homo sapiens]        108   1e-23
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa...   106   6e-23
gi|8923870 solute carrier family 22 member 11 [Homo sapiens]          105   1e-22
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa...   100   5e-21
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa...   100   5e-21
gi|166197673 solute carrier family 22, member 15 [Homo sapiens]        91   2e-18
gi|148664184 solute carrier family 22, member 10 [Homo sapiens]        91   4e-18
gi|211059435 solute carrier family 22, member 24 [Homo sapiens]        90   6e-18
gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]           90   6e-18
gi|157426885 organic cation transporter like 4 [Homo sapiens]          87   3e-17

>gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1
           [Homo sapiens]
          Length = 558

 Score = 1105 bits (2858), Expect = 0.0
 Identities = 558/558 (100%), Positives = 558/558 (100%)

Query: 1   MEQEARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA 60
           MEQEARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA
Sbjct: 1   MEQEARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA 60

Query: 61  LRALRGPALLDAAIPRLGPTRAPAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAGPTWN 120
           LRALRGPALLDAAIPRLGPTRAPAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAGPTWN
Sbjct: 61  LRALRGPALLDAAIPRLGPTRAPAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAGPTWN 120

Query: 121 LVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAASF 180
           LVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAASF
Sbjct: 121 LVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAASF 180

Query: 181 PTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALVQ 240
           PTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALVQ
Sbjct: 181 PTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALVQ 240

Query: 241 DWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGDS 300
           DWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGDS
Sbjct: 241 DWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGDS 300

Query: 301 SLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRASFRR 360
           SLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRASFRR
Sbjct: 301 SLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRASFRR 360

Query: 361 SLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQY 420
           SLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQY
Sbjct: 361 SLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQY 420

Query: 421 LPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGPLDTL 480
           LPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGPLDTL
Sbjct: 421 LPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGPLDTL 480

Query: 481 HGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQDHL 540
           HGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQDHL
Sbjct: 481 HGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQDHL 540

Query: 541 PLLPPSNSYWAGHTPEQH 558
           PLLPPSNSYWAGHTPEQH
Sbjct: 541 PLLPPSNSYWAGHTPEQH 558


>gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6
           [Homo sapiens]
          Length = 560

 Score = 1090 bits (2818), Expect = 0.0
 Identities = 554/560 (98%), Positives = 554/560 (98%), Gaps = 2/560 (0%)

Query: 1   MEQEARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA 60
           MEQEARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA
Sbjct: 1   MEQEARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA 60

Query: 61  LRALRGPALLDAAIPRLGPTRA--PAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAGPT 118
           LRALRGPALLDAAIPRLGPTRA  P   LGVLSPSYLAPLTRAPRPSSWASCSGAAAGPT
Sbjct: 61  LRALRGPALLDAAIPRLGPTRAASPCLPLGVLSPSYLAPLTRAPRPSSWASCSGAAAGPT 120

Query: 119 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 178
           WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA
Sbjct: 121 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 180

Query: 179 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 238
           SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL
Sbjct: 181 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 240

Query: 239 VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPG 298
           VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPG
Sbjct: 241 VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPG 300

Query: 299 DSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRASF 358
           DSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRASF
Sbjct: 301 DSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRASF 360

Query: 359 RRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGA 418
           RRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGA
Sbjct: 361 RRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGA 420

Query: 419 QYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGPLD 478
           QYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAG LD
Sbjct: 421 QYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLD 480

Query: 479 TLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQD 538
           TLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQD
Sbjct: 481 TLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQD 540

Query: 539 HLPLLPPSNSYWAGHTPEQH 558
           HLPLLPPSNSYWAGHTPEQH
Sbjct: 541 HLPLLPPSNSYWAGHTPEQH 560


>gi|239756672 PREDICTED: hypothetical protein LOC146429 [Homo
           sapiens]
          Length = 495

 Score =  877 bits (2266), Expect = 0.0
 Identities = 466/558 (83%), Positives = 475/558 (85%), Gaps = 63/558 (11%)

Query: 1   MEQEARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA 60
           MEQEARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA
Sbjct: 1   MEQEARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA 60

Query: 61  LRALRGPALLDAAIPRLGPTRAPAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAGPTWN 120
           LRALRGPALLDAAIPRLGPTRAPAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAGPTWN
Sbjct: 61  LRALRGPALLDAAIPRLGPTRAPAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAGPTWN 120

Query: 121 LVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAASF 180
           LVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAASF
Sbjct: 121 LVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAASF 180

Query: 181 PTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALVQ 240
           PTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALVQ
Sbjct: 181 PTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALVQ 240

Query: 241 DWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGDS 300
           DWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGDS
Sbjct: 241 DWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGDS 300

Query: 301 SLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRASFRR 360
           SLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRA+   
Sbjct: 301 SLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRAN--- 357

Query: 361 SLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQY 420
                             L    ++FL +          LL    V+ L+SL     A+ 
Sbjct: 358 ------------------LPGWTVLFLSVLG--------LLASRAVSALSSLF---AAEV 388

Query: 421 LPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGPLDTL 480
            P  TV+  + LGL                             VLGAGFLGQAAG LDTL
Sbjct: 389 FP--TVIRGAGLGL-----------------------------VLGAGFLGQAAGLLDTL 417

Query: 481 HGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQDHL 540
           HGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQDHL
Sbjct: 418 HGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQDHL 477

Query: 541 PLLPPSNSYWAGHTPEQH 558
           PLLPPSNSYWAGHTPEQH
Sbjct: 478 PLLPPSNSYWAGHTPEQH 495


>gi|63999576 solute carrier family 22, member 17 isoform b [Homo
           sapiens]
          Length = 520

 Score =  283 bits (725), Expect = 2e-76
 Identities = 180/432 (41%), Positives = 242/432 (56%), Gaps = 7/432 (1%)

Query: 119 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 178
           W+LVC  GW+V LEQ+  +LG+  G + LG   DRFGRR + + +L L    G   A A 
Sbjct: 90  WDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAG 149

Query: 179 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 238
           S   ++ LR L G  LAG  L +YL RLELCDP  RL  ++   L  V G  L  GLA +
Sbjct: 150 SSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALV 209

Query: 239 VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPG 298
            +DWR LQ +      +L LF+G+P LF ES  WL+   Q+  A+ +L   AE +   P 
Sbjct: 210 SKDWRFLQRM-ITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNR--PH 266

Query: 299 DSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRASF 358
              L E +     +L   +   P     S   LL  R  W+N LILGF++ +   IR  +
Sbjct: 267 GQMLGEEAQEALQDLEN-TCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCY 325

Query: 359 RRSLAPQVPT-FYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAG 417
           +       P+ FYL   L +G  A A VFL +T D  GRR +LLL   +TG+ASL+LL  
Sbjct: 326 QPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGL 385

Query: 418 AQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGPL 477
             YL    +   SVLGL +S+A + LS+L AAEV PT +RG GLGL++  G LG  +GP 
Sbjct: 386 WDYLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPA 445

Query: 478 DTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRP-- 535
             LH   G FLQ VV A+ A+L +L ++LLPE++ + LP+ L+D +  RR  LLR  P  
Sbjct: 446 QRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEVLRDGELCRRPSLLRQPPPT 505

Query: 536 RQDHLPLLPPSN 547
           R DH+PLL   N
Sbjct: 506 RCDHVPLLATPN 517


>gi|21361834 solute carrier family 22, member 17 isoform a [Homo
           sapiens]
          Length = 538

 Score =  270 bits (691), Expect = 2e-72
 Identities = 181/450 (40%), Positives = 243/450 (54%), Gaps = 25/450 (5%)

Query: 119 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 178
           W+LVC  GW+V LEQ+  +LG+  G + LG   DRFGRR + + +L L    G   A A 
Sbjct: 90  WDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAG 149

Query: 179 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 238
           S   ++ LR L G  LAG  L +YL RLELCDP  RL  ++   L  V G  L  GLA +
Sbjct: 150 SSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALV 209

Query: 239 VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPG 298
            +DWR LQ +      +L LF+G+P LF ES  WL+   Q+  A+ +L   AE +   P 
Sbjct: 210 SKDWRFLQRM-ITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERN--RPH 266

Query: 299 DSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRASF 358
              L E +     +L   +   P     S   LL  R  W+N LILGF++ +   IR  +
Sbjct: 267 GQMLGEEAQEALQDLEN-TCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCY 325

Query: 359 RRSLAPQVPT-FYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLL-- 415
           +       P+ FYL   L +G  A A VFL +T D  GRR +LLL   +TG+ASL+LL  
Sbjct: 326 QPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGL 385

Query: 416 ----------AGAQY------LPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGA 459
                       AQ       L    +   SVLGL +S+A + LS+L AAEV PT +RG 
Sbjct: 386 WDCEHPIFPTVWAQQGNPNRDLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGR 445

Query: 460 GLGLVLGAGFLGQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSL 519
           GLGL++  G LG  +GP   LH   G FLQ VV A+ A+L +L ++LLPE++ + LP+ L
Sbjct: 446 GLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEVL 505

Query: 520 QDADRLRRSPLLRGRP--RQDHLPLLPPSN 547
           +D +  RR  LLR  P  R DH+PLL   N
Sbjct: 506 RDGELCRRPSLLRQPPPTRCDHVPLLATPN 535


>gi|170650643 solute carrier family 22, member 23 isoform a [Homo
           sapiens]
          Length = 686

 Score =  260 bits (664), Expect = 3e-69
 Identities = 186/575 (32%), Positives = 282/575 (49%), Gaps = 54/575 (9%)

Query: 1   MEQEARVLRAAGGFGRA-RRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRP--DPTLL 57
           ++ +  VL   GG G   ++ L   +W+P + +G    S+  L  QP   CR     T L
Sbjct: 78  LDYDGSVLPFLGGLGGGYQKTLVLLTWIPALFIGFSQFSDSFLLDQPNFWCRGAGKGTEL 137

Query: 58  PPALRALRGPALLD-AAIPRLGPTRAPAEALGVLSPSYLA------PLTRAPRPSSWAS- 109
                  RG  + +  ++P      AP EA G  S S  A      PL   P     AS 
Sbjct: 138 AGVTTTGRGGDMGNWTSLPTTPFATAPWEAAGNRSNSSGADGGDTPPLPSPPDKGDNASN 197

Query: 110 CS------GAAAG------PTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRR 157
           C       G  AG        W+LVC + WKV + + S L+G + G +I G   D  GRR
Sbjct: 198 CDCRAWDYGIRAGLVQNVVSKWDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRR 257

Query: 158 AVFVASLVLTTGLGASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAF 217
            V + S++     G + AL+ +      LR   G  LAG +L LY  R+ELC P  R   
Sbjct: 258 PVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMI 317

Query: 218 SMGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATG 277
           +M A   ++ G  L+PGLAAL +DW++LQ L      L+LL+W   ++FPES  WL+AT 
Sbjct: 318 TMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYW---SIFPESLRWLMATQ 374

Query: 278 QVARARKILWRFAEASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVT 337
           Q   A++++  F + + + P     E +      EL    +R  +P+    + ++ TR  
Sbjct: 375 QFESAKRLILHFTQKNRMNP-----EGDIKGVIPELEKELSR--RPKKVCIVKVVGTRNL 427

Query: 338 WRNGLILGFSSLVGGGIRASFRRSL------APQVPTFYLPYFLEAGLEAAALVFLLLTA 391
           W+N ++L  +SL G GI   F RS+       P +  FY  Y+  A +   + + + +  
Sbjct: 428 WKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPLLENFYADYYTTASIALVSCLAMCVVV 487

Query: 392 DCCGRRPVLLLGTMVTGLASLLLLAGAQYLPGWT---------------VLFLSVLGLLA 436
              GRR  LLL  ++T LASLL L     +  ++                +  S++G+ A
Sbjct: 488 RFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFA 547

Query: 437 SRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGPLDTLHGRQGFFLQQVVFASL 496
           S AV +LS  F AE+ PTVIR  GLGLVL +   G    P+  LH ++G+FL  ++FA  
Sbjct: 548 SHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFACC 607

Query: 497 AVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLL 531
            ++ ++C+LLLPESR + LP+++ + +   R PLL
Sbjct: 608 TLICIICILLLPESRDQNLPENISNGEHYTRQPLL 642


>gi|48526516 solute carrier family 22, member 23 isoform b [Homo
           sapiens]
          Length = 405

 Score =  208 bits (529), Expect = 1e-53
 Identities = 127/367 (34%), Positives = 196/367 (53%), Gaps = 31/367 (8%)

Query: 186 LRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALVQDWRLL 245
           LR   G  LAG +L LY  R+ELC P  R   +M A   ++ G  L+PGLAAL +DW++L
Sbjct: 5   LRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVL 64

Query: 246 QGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGDSSLEEN 305
           Q L      L+LL+W   ++FPES  WL+AT Q   A++++  F + + + P     E +
Sbjct: 65  QALIICPFLLMLLYW---SIFPESLRWLMATQQFESAKRLILHFTQKNRMNP-----EGD 116

Query: 306 SLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRASFRRSL--- 362
                 EL    +R  +P+    + ++ TR  W+N ++L  +SL G GI   F RS+   
Sbjct: 117 IKGVIPELEKELSR--RPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGH 174

Query: 363 ---APQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQ 419
               P +  FY  Y+  A +   + + + +     GRR  LLL  ++T LASLL L    
Sbjct: 175 EVKVPLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLN 234

Query: 420 YLPGWTV---------------LFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLV 464
            +  ++                +  S++G+ AS AV +LS  F AE+ PTVIR  GLGLV
Sbjct: 235 LIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLV 294

Query: 465 LGAGFLGQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADR 524
           L +   G    P+  LH ++G+FL  ++FA   ++ ++C+LLLPESR + LP+++ + + 
Sbjct: 295 LASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPENISNGEH 354

Query: 525 LRRSPLL 531
             R PLL
Sbjct: 355 YTRQPLL 361


>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
          Length = 557

 Score =  150 bits (379), Expect = 3e-36
 Identities = 159/555 (28%), Positives = 238/555 (42%), Gaps = 50/555 (9%)

Query: 12  GGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCR-PDPTLLPPALRALRGPALL 70
           G F R    L SAS +P    GL   S   L A P   CR PD   L  A R    P  L
Sbjct: 15  GPFQRLIFFLLSASIIPNGFTGL---SSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRL 71

Query: 71  --DAAIP------RLGPTRAPAEALGVLSPSYLAPLTRAPRPS---SWASCSGAAAGPT- 118
                +P      RL  T A   ALG L P     L +  + S    W            
Sbjct: 72  RDGREVPHSCRRYRLA-TIANFSALG-LEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIV 129

Query: 119 --WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEAL 176
             WNLVC D WK PL      +G LLG  I G   DRFGR+ V   ++ + TG    +  
Sbjct: 130 TEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIF 189

Query: 177 AASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFS-MGAGLFSVVGTLLLPGL 235
           + +F   +VL +L G       +A ++   E+     R+ FS +G  +F   G ++LP  
Sbjct: 190 SKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLF 249

Query: 236 AALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGV 295
           A  ++DWR+L     +   L +  W F    PESP WL++ G+   A  I+ + A+A+G+
Sbjct: 250 AYFIRDWRMLLVALTMPGVLCVALWWF---IPESPRWLISQGRFEEAEVIIRKAAKANGI 306

Query: 296 GPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIR 355
                 +  +++   +EL  LS++  Q   H+ L LLR   TW   ++   S ++   I 
Sbjct: 307 ------VVPSTIFDPSELQDLSSKKQQS--HNILDLLR---TWNIRMVTIMSIMLWMTIS 355

Query: 356 ASFRRSLAPQVPT----FYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLAS 411
             +   L+   P      ++  FL A +E  A V   L      RR  +     + G   
Sbjct: 356 VGY-FGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVL 414

Query: 412 LLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSL---FAAEVFPTVIRGAGLGLVLGAG 468
           L +    Q +P       +VL ++    V+A  S+   + AE++PTV+R  G+G+   A 
Sbjct: 415 LFM----QLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTAS 470

Query: 469 FLGQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRS 528
            LG    P     G    FL  ++  SL +L  +  L LPES    LP ++   D++ R 
Sbjct: 471 RLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTI---DQMLRV 527

Query: 529 PLLRGRPRQDHLPLL 543
             ++ R    H  +L
Sbjct: 528 KGMKHRKTPSHTRML 542


>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
          Length = 555

 Score =  141 bits (356), Expect = 1e-33
 Identities = 110/421 (26%), Positives = 196/421 (46%), Gaps = 23/421 (5%)

Query: 112 GAAAGPTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLG 171
           G++    +NLVC + W + L Q S  +G+ +G + +G   DRFGR+   + ++++    G
Sbjct: 132 GSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAG 191

Query: 172 ASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLL 231
              A++ ++  +L+ RL+ G       L  Y+   E     +R    +   +   VG L+
Sbjct: 192 VLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLV 251

Query: 232 LPGLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAE 291
           L G+A  +  WR LQ   AL +   LL++      PESP WL++  + A A +I+   A+
Sbjct: 252 LAGVAYALPHWRWLQFTVALPNFFFLLYYW---CIPESPRWLISQNKNAEAMRIIKHIAK 308

Query: 292 ASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVG 351
            +G           SL  + +   L   + +    S L L+RT    ++ +IL ++    
Sbjct: 309 KNG----------KSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTS 358

Query: 352 GGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLAS 411
             +       +       YL +F  A +E  A   ++LT D  GRR       MV G A 
Sbjct: 359 SVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAAC 418

Query: 412 LLLLAGAQYLPG---WTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAG 468
           L     + ++PG   W  + +S LG +       +  L  AE++PT IR  G+ +     
Sbjct: 419 L----ASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMC 474

Query: 469 FLGQAAGPLDTLHGRQGFFLQ--QVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLR 526
            +G    P   ++     +L+   +VF  L ++A   VLLLPE++ + LP+++++A+ ++
Sbjct: 475 DIGGIITPF-LVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQ 533

Query: 527 R 527
           R
Sbjct: 534 R 534


>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
          Length = 556

 Score =  138 bits (348), Expect = 1e-32
 Identities = 126/476 (26%), Positives = 202/476 (42%), Gaps = 31/476 (6%)

Query: 58  PPALRALRGPALLDAAIPRLGPTRAPAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAGP 117
           PP  R      LL+AA      + +   AL    P    P   AP          A A  
Sbjct: 83  PPERRGRCQRYLLEAA----NDSASATSALSCADPLAAFPNRSAPLVPCRGGWRYAQAHS 138

Query: 118 T----WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGAS 173
           T    ++LVC + W + L Q    LG+L G   LG   DR+GR  +++ S +     G  
Sbjct: 139 TIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGVV 198

Query: 174 EALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLP 233
            A A +FP  ++ R L G    G  +  Y+   E+     R    +   +F  +G ++LP
Sbjct: 199 VAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFTLGIIILP 258

Query: 234 GLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEAS 293
           G+A  + +W+ +Q    L S L LL++    + PESP WL+   +  +A +IL R A+ +
Sbjct: 259 GIAYFIPNWQGIQLAITLPSFLFLLYYW---VVPESPRWLITRKKGDKALQILRRIAKCN 315

Query: 294 GVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGG 353
           G       L  N     +E+T+       P +   L L+RT    +  LIL F+      
Sbjct: 316 G-----KYLSSN----YSEITVTDEEVSNPSF---LDLVRTPQMRKCTLILMFAWFTSAV 363

Query: 354 IRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLL 413
           +       L       Y+ +F+   +E    + +LLT +  GRR       +V G+A L+
Sbjct: 364 VYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLV 423

Query: 414 LLAGAQYLP---GWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFL 470
                 +LP    W    ++ LG L       +  L  +E++PT +R  G+ L  G    
Sbjct: 424 ----TAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDF 479

Query: 471 GQAAGPLDTLH-GRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRL 525
           G    P            L  ++F  LA +    V+LLPE++   LP+++ D ++L
Sbjct: 480 GGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKL 535


>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
          Length = 542

 Score =  137 bits (346), Expect = 2e-32
 Identities = 145/549 (26%), Positives = 227/549 (41%), Gaps = 47/549 (8%)

Query: 5   ARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRAL 64
           + +L   G  G  + L  +   +P + +      +    A P  HCRP          A 
Sbjct: 4   SEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHN-------AS 56

Query: 65  RGPALLDAAIPRLGPTRAPAEALGVLSP---SYLAPLTRAPRP--SSWASCSGAAAGPT- 118
            GP +L      +GP   P   L  + P   S      RA  P    W   S   +  T 
Sbjct: 57  TGPWVLP-----MGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTE 111

Query: 119 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 178
           W+LVC       + Q   + G L+G ++LG   DRFGRR +   S +L    G+  A + 
Sbjct: 112 WDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSP 171

Query: 179 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 238
           +FP  +V R L G  ++G  L+  +  +E      R   S   G     G  +LPGLA  
Sbjct: 172 TFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYA 231

Query: 239 VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPG 298
           +  WR LQ     +S    +F+      PES  WL+ +G+ ++A KIL R A  +G    
Sbjct: 232 IPQWRWLQ---LTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEE 288

Query: 299 DS--SLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRA 356
               SLEE  L    E+++  A+      ++   L R  +  R    L  +    G    
Sbjct: 289 GERLSLEELKLNLQKEISLAKAK------YTASDLFRIPMLRRMTFCLSLAWFATGFAYY 342

Query: 357 SFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLA 416
           S    +       Y+   +  G++  A    +L+    GR          T  A+LLL  
Sbjct: 343 SLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRH--------TTQAAALLLAG 394

Query: 417 GAQYLPGWTVLFL-SVLGLLASRAVSALSS------LFAAEVFPTVIRGAGLGLVLGAGF 469
           GA     +  L L +V  +LA      LSS      L+ +E++PTVIR  G+G+      
Sbjct: 395 GAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTR 454

Query: 470 LGQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSP 529
           +G    PL  + G    F+  +++   A+L     L LPE+ ++ LP++++D   L    
Sbjct: 455 VGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIED---LENWS 511

Query: 530 LLRGRPRQD 538
           L   +P+Q+
Sbjct: 512 LRAKKPKQE 520


>gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]
          Length = 553

 Score =  137 bits (345), Expect = 3e-32
 Identities = 157/551 (28%), Positives = 232/551 (42%), Gaps = 59/551 (10%)

Query: 5   ARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHC----RPDPTLLPPA 60
           + +L   GG GR + L   A  V  + L      E    A P+  C      + T     
Sbjct: 4   SELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASI 63

Query: 61  LRALRGPALLDAAIPRLGPTRAPAEALGVLSPSY--LAPLTRA---------PRPSSWA- 108
           L +L   ALL  +IP  GP + P +      P +  L P   A         P    W  
Sbjct: 64  LGSLSPEALLAISIPP-GPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVY 122

Query: 109 --SCSGAAAGPTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVL 166
             S   +     WNLVC      P+ Q  +L G L+G    G   DRFGRR V   S + 
Sbjct: 123 DRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQ 182

Query: 167 TTGLGASEALAASFPTLLVLRLLHGGTLAGALLALYLARLE--------LCDPPHRLAFS 218
              +G + A A +FP   + R L    +AG ++      +E        L    + L FS
Sbjct: 183 MAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFS 242

Query: 219 MGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQ 278
            G GL + V        A  V+DW LLQ + ++   L  L+  + A   ES  WLL TG+
Sbjct: 243 FGHGLTAAV--------AYGVRDWTLLQLVVSVPFFLCFLYSWWLA---ESARWLLTTGR 291

Query: 279 VARARKILWRFAEASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLL------ 332
           +    + LWR A  +G G    +L    L +A    +   + P     + LG L      
Sbjct: 292 LDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPP-----ASLGTLLRMPGL 346

Query: 333 --RTRVTWRNGLILGFSSLVGGGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLT 390
             RT ++       GF+     G+    + +L   +  F L  F+   ++  A +  LL 
Sbjct: 347 RFRTCISTLCWFAFGFTFF---GLALDLQ-ALGSNI--FLLQMFIGV-VDIPAKMGALLL 399

Query: 391 ADCCGRRPVLLLGTMVTGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAE 450
               GRRP L    ++ GL  +L      +  G     L+VLGL    A     +++++E
Sbjct: 400 LSHLGRRPTLAASLLLAGLC-ILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSE 458

Query: 451 VFPTVIRGAGLGLVLGAGFLGQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPES 510
           +FPTV+R   +GL   A   G   GPL  L G  G +L  +V+ ++ VL+ L  LLLPE+
Sbjct: 459 LFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPET 518

Query: 511 RSRGLPQSLQD 521
           +S  LP ++QD
Sbjct: 519 QSLPLPDTIQD 529


>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
           sapiens]
          Length = 548

 Score =  136 bits (343), Expect = 4e-32
 Identities = 124/421 (29%), Positives = 187/421 (44%), Gaps = 24/421 (5%)

Query: 111 SGAAAGPTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGL 170
           S  A    W+LVC               G L+G V  G   DRFGRR + + + V T  L
Sbjct: 126 STIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVL 185

Query: 171 GASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTL 230
           G + A + S+    + R L G  LAG  + +    LE  D  HR    + +  F   G +
Sbjct: 186 GLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWTGGVM 245

Query: 231 LLPGLAALVQDWR--LLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWR 288
           LL  +  L++DWR  LL        G+L L+W      PES  WLL  G V  A + L  
Sbjct: 246 LLALVGYLIRDWRWLLLAVTLPCAPGILSLWW-----VPESARWLLTQGHVKEAHRYLLH 300

Query: 289 FAEASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSS 348
            A  +G    + S  + +++       ++A     R  S L L RT       L      
Sbjct: 301 CARLNGRPVCEDSFSQEAVSK------VAAGERVVRRPSYLDLFRTPRLRHISLCC---V 351

Query: 349 LVGGGIRASFRRSLAPQVP----TFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGT 404
           +V  G+  S+   L+  V       Y    L   +E  + + + L+    GRR +   GT
Sbjct: 352 VVWFGVNFSYY-GLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRR-LTQAGT 409

Query: 405 MV-TGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGL 463
           ++ T LA    L  +  +  W+ + L+V+G   S A    + LF +E++PTV+R  G+GL
Sbjct: 410 LLGTALAFGTRLLVSSDMKSWSTV-LAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGL 468

Query: 464 VLGAGFLGQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDAD 523
               G LG +  PL  L       L ++ +  +A+LA    LLLPE+R   LP+++QD +
Sbjct: 469 TALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVE 528

Query: 524 R 524
           R
Sbjct: 529 R 529


>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
           sapiens]
          Length = 546

 Score =  136 bits (342), Expect = 6e-32
 Identities = 122/413 (29%), Positives = 185/413 (44%), Gaps = 24/413 (5%)

Query: 119 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 178
           W+LVC               G L+G V  G   DRFGRR + + + V T  LG + A + 
Sbjct: 132 WDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAASV 191

Query: 179 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 238
           S+    + R L G  LAG  + +    LE  D  HR    + +  F   G +LL  +  L
Sbjct: 192 SYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWTGGVMLLALVGYL 251

Query: 239 VQDWR--LLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVG 296
           ++DWR  LL        G+L L+W      PES  WLL  G V  A + L   A  +G  
Sbjct: 252 IRDWRWLLLAVTLPCAPGILSLWW-----VPESARWLLTQGHVKEAHRYLLHCARLNGRP 306

Query: 297 PGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRA 356
             + S  + +++       ++A     R  S L L RT       L      +V  G+  
Sbjct: 307 VCEDSFSQEAVSK------VAAGERVVRRPSYLDLFRTPRLRHISLCC---VVVWFGVNF 357

Query: 357 SFRRSLAPQVP----TFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMV-TGLAS 411
           S+   L+  V       Y    L   +E  + + + L+    GRR +   GT++ T LA 
Sbjct: 358 SYY-GLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRR-LTQAGTLLGTALAF 415

Query: 412 LLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLG 471
              L  +  +  W+ + L+V+G   S A    + LF +E++PTV+R  G+GL    G LG
Sbjct: 416 GTRLLVSSDMKSWSTV-LAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLG 474

Query: 472 QAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADR 524
            +  PL  L       L ++ +  +A+LA    LLLPE+R   LP+++QD +R
Sbjct: 475 GSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVER 527


>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
           sapiens]
          Length = 554

 Score =  130 bits (327), Expect = 3e-30
 Identities = 139/545 (25%), Positives = 229/545 (42%), Gaps = 50/545 (9%)

Query: 21  LASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRGPAL-LDAAIPRLGP 79
           L SA++ P I +G+V      L   P  HC+  P +   + R    PA  L+  +P LGP
Sbjct: 27  LLSAAFAP-ICVGIVF-----LGFTPDHHCQ-SPGVAELSQRCGWSPAEELNYTVPGLGP 79

Query: 80  TRAP-------------AEALGVLSPSYLAPLTRAPRP-----SSWA-SCSGAAAGPTWN 120
                              AL  + P       R+  P       W     G++    +N
Sbjct: 80  AGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWVYDTPGSSIVTEFN 139

Query: 121 LVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAASF 180
           LVC D WK+ L Q     G+L G + +G   DRFGR+   + ++++    G   A + ++
Sbjct: 140 LVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNY 199

Query: 181 PTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALVQ 240
            ++L+ RLL G    G  +A Y    E      R   ++   +   VG + L GLA  + 
Sbjct: 200 MSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYALP 259

Query: 241 DWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGDS 300
            WR LQ   +L + L LL++      PESP WLL+  +   A KI+   A+ +G  P   
Sbjct: 260 HWRWLQLAVSLPTFLFLLYYW---CVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLP--- 313

Query: 301 SLEENSLATATELTMLSARSPQPRYHSP--LGLLRTRVTWRNGLILGFSSLVGGGIRASF 358
                      +L MLS         SP    L RT    +   IL +       +    
Sbjct: 314 ---------PADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGL 364

Query: 359 RRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGA 418
              +       YL +   A +E       L+T D  GR   + +  ++ G A L+++  +
Sbjct: 365 ILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFIS 424

Query: 419 QYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGPLD 478
             L  W  + +  +G +       +  L  AE++PT +R  G+ +      +G    P  
Sbjct: 425 PDL-HWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFI 483

Query: 479 TLHGRQGF-FLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQ 537
               R+ +  L  ++FA L +LA    LLLPE++   LP++++DA+ L R    + +P++
Sbjct: 484 VFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAENLGR----KAKPKE 539

Query: 538 DHLPL 542
           + + L
Sbjct: 540 NTIYL 544


>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
          Length = 551

 Score =  127 bits (320), Expect = 2e-29
 Identities = 113/414 (27%), Positives = 183/414 (44%), Gaps = 25/414 (6%)

Query: 119 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 178
           WNLVC D WKVPL      +G LLG  + G   DRFGR+ V  A++ + TG    +  + 
Sbjct: 132 WNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQIFSI 191

Query: 179 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFS-MGAGLFSVVGTLLLPGLAA 237
           S+    VL ++ G       +  ++   E+     R+ FS +G   F  VG +LLP  A 
Sbjct: 192 SWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAY 251

Query: 238 LVQDWRLLQGLGALMSGLLLL-FWGFPALFPESPCWLLATGQVARARKILWRFAEASGVG 296
            ++DWR+L  L   + G+L +  W F    PESP WL++  +   A  I+ + A+ + + 
Sbjct: 252 FIRDWRMLL-LALTVPGVLCVPLWWF---IPESPRWLISQRRFREAEDIIQKAAKMNNI- 306

Query: 297 PGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRA 356
               ++      +  EL  L  +         L L RT    RN  I+   SL+   + +
Sbjct: 307 ----AVPAVIFDSVEELNPLKQQKA-----FILDLFRT----RNIAIMTIMSLLLWMLTS 353

Query: 357 SFRRSLAPQVPTF----YLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASL 412
               +L+   P      YL  FL A +E  A +   L      RR  ++   +  G   L
Sbjct: 354 VGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRR-YIIAAVLFWGGGVL 412

Query: 413 LLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQ 472
           L +        +  + L +LG     +  ++  +F AE++PT++R   +G+   A  +G 
Sbjct: 413 LFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGS 472

Query: 473 AAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLR 526
              P     G     L  +V  SL VL  +  L  PES    LP++L+   +++
Sbjct: 473 IIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVK 526


>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
           sapiens]
          Length = 550

 Score =  124 bits (312), Expect = 2e-28
 Identities = 134/557 (24%), Positives = 221/557 (39%), Gaps = 41/557 (7%)

Query: 7   VLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRG 66
           +L+  GG GR +++  +   +P +++    + +    A P  HCRP      PA   L  
Sbjct: 6   LLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRP------PADANLSK 59

Query: 67  PALLDAAIPRLGPTRAPAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAG---------- 116
              L+  +PR      P   L   SP +  P       +   +      G          
Sbjct: 60  NGGLEVWLPR-DRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPS 118

Query: 117 ---PTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGAS 173
                W+LVC       L Q  +++G LLG ++ G   DR GRR V + + + T   G  
Sbjct: 119 TIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTC 178

Query: 174 EALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLP 233
            A A +FP     RLL G  LAG  L      +E      R       G    +G  LL 
Sbjct: 179 AAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLA 238

Query: 234 GLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEAS 293
           G+A  V  WR LQ    L+S     F+ +   F ES  W  ++G++    + L R A  +
Sbjct: 239 GVAYAVPHWRHLQ---LLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARIN 295

Query: 294 GVGPGDSSLEENSLATAT--ELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVG 351
           G     + L    L  +   ELTM   ++      S + LLR        L L       
Sbjct: 296 GKREEGAKLSMEVLRASLQKELTMGKGQA------SAMELLRCPTLRHLFLCLSMLWFAT 349

Query: 352 GGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLAS 411
                     L     + YL   +   ++  A +   L  +  GRRP  +   ++ G+  
Sbjct: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGIC- 408

Query: 412 LLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSS---LFAAEVFPTVIRGAGLGLVLGAG 468
            +LL G   +P    +  + L +L    ++A  +   L+  E++PT+IR  G+G+     
Sbjct: 409 -ILLNGV--IPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMA 465

Query: 469 FLGQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRS 528
            +G    PL ++       +   ++ ++ V A    +LLPE+  + LP ++QD +  +  
Sbjct: 466 RVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRKGK 525

Query: 529 PLLRGRPRQDHLPLLPP 545
              + R +Q+H   + P
Sbjct: 526 ---QTRQQQEHQKYMVP 539


>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
           sapiens]
          Length = 563

 Score =  122 bits (307), Expect = 7e-28
 Identities = 130/535 (24%), Positives = 212/535 (39%), Gaps = 38/535 (7%)

Query: 7   VLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRG 66
           +L+  GG GR +++  +   +P +++    + +    A P  HCRP      PA   L  
Sbjct: 6   LLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRP------PADANLSK 59

Query: 67  PALLDAAIPRLGPTRAPAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAG---------- 116
              L+  +PR      P   L   SP +  P       +   +      G          
Sbjct: 60  NGGLEVWLPR-DRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPS 118

Query: 117 ---PTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGAS 173
                W+LVC       L Q  +++G LLG ++ G   DR GRR V + + + T   G  
Sbjct: 119 TIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTC 178

Query: 174 EALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLP 233
            A A +FP     RLL G  LAG  L      +E      R       G    +G  LL 
Sbjct: 179 AAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLA 238

Query: 234 GLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEAS 293
           G+A  V  WR LQ    L+S     F+ +   F ES  W  ++G++    + L R A  +
Sbjct: 239 GVAYAVPHWRHLQ---LLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARIN 295

Query: 294 GVGPGDSSLEENSLATA--TELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVG 351
           G     + L    L  +   ELTM   ++      S + LLR        L L       
Sbjct: 296 GKREEGAKLSMEVLRASLQKELTMGKGQA------SAMELLRCPTLRHLFLCLSMLWFAT 349

Query: 352 GGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLAS 411
                     L     + YL   +   ++  A +   L  +  GRRP  +   ++ G+  
Sbjct: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGIC- 408

Query: 412 LLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSS---LFAAEVFPTVIRGAGLGLVLGAG 468
            +LL G   +P    +  + L +L    ++A  +   L+  E++PT+IR  G+G+     
Sbjct: 409 -ILLNGV--IPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMA 465

Query: 469 FLGQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDAD 523
            +G    PL ++       +   ++ ++ V A    +LLPE+  + LP ++QD +
Sbjct: 466 RVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLE 520


>gi|166064021 solute carrier family 22 (organic anion transporter),
           member 13 [Homo sapiens]
          Length = 551

 Score =  121 bits (303), Expect = 2e-27
 Identities = 121/413 (29%), Positives = 189/413 (45%), Gaps = 32/413 (7%)

Query: 119 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 178
           +NLVC         Q   + G L+G ++ G  CDR GR+A  +A L+L T +G + A   
Sbjct: 127 FNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLATAFVP 186

Query: 179 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 238
           SF   + LR      +AG   +      E   P  R    + A     +G ++L GLA  
Sbjct: 187 SFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVLAGLAYG 246

Query: 239 VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEAS--GVG 296
            ++WRLLQ  G      LLLF+ F AL PES  WLL  G++  A +++ + A  +   + 
Sbjct: 247 FRNWRLLQITGTAPG--LLLFFYFWAL-PESARWLLTRGRMDEAIQLIQKAASVNRRKLS 303

Query: 297 PG--DSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGI 354
           P   +  + E +  +   L +   R PQ R          +VT     +    SL   G 
Sbjct: 304 PELMNQLVPEKTGPSGNALDLF--RHPQLR----------KVTLIIFCVWFVDSLGYYG- 350

Query: 355 RASFRRSLAPQVPTF----YLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLA 410
                  L+ QV  F    YL   +   +E  A    +      GR+   L   ++ GL 
Sbjct: 351 -------LSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLM 403

Query: 411 SLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFL 470
            ++++     LP   V  L+V+G +A+ A   +S +++AE+FPT++R  G+GLV     +
Sbjct: 404 CIIIIFIPADLP-VVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRI 462

Query: 471 GQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDAD 523
           G    PL  L G     L  +++ SL ++A L   LLPE+  +GL  +LQD +
Sbjct: 463 GGILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLE 515


>gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
          Length = 555

 Score =  111 bits (277), Expect = 2e-24
 Identities = 145/541 (26%), Positives = 219/541 (40%), Gaps = 46/541 (8%)

Query: 7   VLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRG 66
           +L A G  GR +    +   +PC +L      +    A P  HCR  P     A     G
Sbjct: 6   LLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCR-GPANHTEASTNDSG 64

Query: 67  PALLDAAIPRLGPTRAPAEALGVLSPSY--LAPLTRAPRPSSWASCSGAAAGPT------ 118
            A L A IP L    AP        P +  L+P +  P  ++     G     +      
Sbjct: 65  -AWLRATIP-LDQLGAPEPCRRFTKPQWALLSPNSSIPGAATEGCKDGWVYNRSVFPSTI 122

Query: 119 ---WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEA 175
              W+LVC       L Q  ++ G L+G  + G+  DR G +   V S +     GA+ A
Sbjct: 123 VMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAASGAATA 182

Query: 176 LAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGL 235
             +SF    V R L G T +G +L      +E      R    +  G    +G L+L G+
Sbjct: 183 YFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTLGQLILAGV 242

Query: 236 AALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGV 295
           A L++ WR LQ     +S   L+F+ +    PES  WLL  G+   A + L + A  +G 
Sbjct: 243 AYLIRPWRCLQ---FAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVAAMNGR 299

Query: 296 GPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNG---LILGFSSLVGG 352
                 L +  +++  +    S  +     +S L L RT    +     +++ FS+ V  
Sbjct: 300 KEEGERLTKEVMSSYIQSEFASVCTS----NSILDLFRTPAIRKVTCCLMVIWFSNSVA- 354

Query: 353 GIRASFRRSLAPQVPTFYLPYFLEAGL----EAAALVFLLLTADCCGRRP-----VLLLG 403
                    LA  +  F L  +L   L       A++    T    GRR      ++L G
Sbjct: 355 ------YYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAG 408

Query: 404 TMVTGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGL 463
            MV  +A++ +  G Q L   T       G LAS  +     LF  E++PT IR  G+G 
Sbjct: 409 LMV--IANMFVPEGTQIL--CTAQAALGKGCLASSFICVY--LFTGELYPTEIRQMGMGF 462

Query: 464 VLGAGFLGQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDAD 523
                 LG    PL T  G     L  V F + A+LA L V +L E+R+  L +++   +
Sbjct: 463 ASVHARLGGLTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAME 522

Query: 524 R 524
           R
Sbjct: 523 R 523


>gi|31542327 solute carrier family 22, member 16 [Homo sapiens]
          Length = 577

 Score =  108 bits (270), Expect = 1e-23
 Identities = 110/417 (26%), Positives = 177/417 (42%), Gaps = 28/417 (6%)

Query: 119 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 178
           WNLVC   W   L Q   + G LLG V  G   DR GRR V  A+       G + A A 
Sbjct: 144 WNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAV 203

Query: 179 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 238
            + T +  R       +G L+  ++  +E      R   S+    F  VGTLL+     L
Sbjct: 204 DYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYL 263

Query: 239 VQDWRLLQG-LGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGP 297
           V+ W L Q  L  +    +L  W    + PE+P WLL+ G+   A+KI+   A+ +    
Sbjct: 264 VRTWWLYQMILSTVTVPFILCCW----VLPETPFWLLSEGRYEEAQKIVDIMAKWNRA-- 317

Query: 298 GDSSLEENSLATATELTMLSARSPQPRYHSPLGLL-------RTRVTWRNGLILGFSSLV 350
             SS + + L +      +S    + + H+   L        RT   W    ++ F+  +
Sbjct: 318 --SSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVW----LIWFTGSL 371

Query: 351 GGGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLA 410
           G     SF  +        YL  FL   +E  A  F+ +  D  GRR VL      + LA
Sbjct: 372 GF---YSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALA 428

Query: 411 S--LLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAG 468
              ++++    Y+ G   +  +++G  A  A   L  L+ AE++PT++R   +G      
Sbjct: 429 CGVVMVIPQKHYILG---VVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVC 485

Query: 469 FLGQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRL 525
            L     P          F+ Q+   ++A+L+ +  L LPE+  + L  + ++A +L
Sbjct: 486 RLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAAKL 542


>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
           sapiens]
          Length = 506

 Score =  106 bits (264), Expect = 6e-23
 Identities = 117/462 (25%), Positives = 186/462 (40%), Gaps = 45/462 (9%)

Query: 21  LASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRGPAL-LDAAIPRLGP 79
           L SA++ P I +G+V      L   P  HC+  P +   + R    PA  L+  +P LGP
Sbjct: 27  LLSAAFAP-ICVGIVF-----LGFTPDHHCQ-SPGVAELSQRCGWSPAEELNYTVPGLGP 79

Query: 80  TRAP-------------AEALGVLSPSYLAPLTRAPRP-----SSWA-SCSGAAAGPTWN 120
                              AL  + P       R+  P       W     G++    +N
Sbjct: 80  AGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWVYDTPGSSIVTEFN 139

Query: 121 LVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAASF 180
           LVC D WK+ L Q     G+L G + +G   DRFGR+   + ++++    G   A + ++
Sbjct: 140 LVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNY 199

Query: 181 PTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALVQ 240
            ++L+ RLL G    G  +A Y    E      R   ++   +   VG + L GLA  + 
Sbjct: 200 MSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYALP 259

Query: 241 DWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGDS 300
            WR LQ   +L + L LL++      PESP WLL+  +   A KI+   A+ +G  P   
Sbjct: 260 HWRWLQLAVSLPTFLFLLYYW---CVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLP--- 313

Query: 301 SLEENSLATATELTMLSARSPQPRYHSP--LGLLRTRVTWRNGLILGFSSLVGGGIRASF 358
                      +L MLS         SP    L RT    +   IL +       +    
Sbjct: 314 ---------PADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGL 364

Query: 359 RRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGA 418
              +       YL +   A +E       L+T D  GR   + +  ++ G A L+++  +
Sbjct: 365 ILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFIS 424

Query: 419 QYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAG 460
             L  W  + +  +G +       +  L  AE++PT + G G
Sbjct: 425 PDL-HWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVSGVG 465


>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
          Length = 550

 Score =  105 bits (261), Expect = 1e-22
 Identities = 137/539 (25%), Positives = 217/539 (40%), Gaps = 34/539 (6%)

Query: 5   ARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRAL 64
           +++L  AGG G  + L      +PC+++   +  E    A P   C         A+   
Sbjct: 4   SKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAVSTN 63

Query: 65  RGP-ALLDAAIPRLGPTRAPAEALGVLSPSY--LAPLTRA---------PRPSSWA---S 109
             P ALL  +IP  GP + P +      P +  L P   A         P    W    S
Sbjct: 64  MTPKALLTISIPP-GPNQGPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRS 122

Query: 110 CSGAAAGPTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTG 169
              +     W+LVC      PL Q   + G L+G  I G    RFGR+ +     +    
Sbjct: 123 VFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCCLQLAV 182

Query: 170 LGASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGT 229
            G S   A +F     LR +    +AG  L+     +E      R       G     G 
Sbjct: 183 AGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCAFSAGQ 242

Query: 230 LLLPGLAALVQDWRLLQGLGAL-MSGLLLLFWGFPALFPESPCWLLATGQVARARKILWR 288
             L GLA  ++DWR LQ   ++    + L+ W      PES  WL+  G+  +A + L +
Sbjct: 243 AALGGLAFALRDWRTLQLAASVPFFAISLISW----WLPESARWLIIKGKPDQALQELRK 298

Query: 289 FAEASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRV-TWRN--GLILG 345
            A  +G      +L    L ++ +  + SA+ P+    S L L    V  WR+   L++ 
Sbjct: 299 VARINGHKEA-KNLTIEVLMSSVKEEVASAKEPR----SVLDLFCVPVLRWRSCAMLVVN 353

Query: 346 FSSLVGGGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTM 405
           FS L+         +SL   +   +L   L   ++        L     GRR +      
Sbjct: 354 FSLLISYYGLVFDLQSLGRDI---FLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQA 410

Query: 406 VTGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVL 465
           + GLA L  +   Q L    V+F +VLG           +++ AE+FPT +R    G++ 
Sbjct: 411 MAGLAILANMLVPQDLQTLRVVF-AVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILH 469

Query: 466 GAGFLGQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVL-LLPESRSRGLPQSLQDAD 523
             G LG   GPL  +  +    L  +++  +++ + L VL  LPE++   LP ++QD +
Sbjct: 470 TVGRLGAMMGPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDLE 528


>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
           sapiens]
          Length = 519

 Score =  100 bits (248), Expect = 5e-21
 Identities = 115/469 (24%), Positives = 181/469 (38%), Gaps = 38/469 (8%)

Query: 7   VLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRG 66
           +L+  GG GR +++  +   +P +++    + +    A P  HCRP      PA   L  
Sbjct: 6   LLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRP------PADANLSK 59

Query: 67  PALLDAAIPRLGPTRAPAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAG---------- 116
              L+  +PR      P   L   SP +  P       +   +      G          
Sbjct: 60  NGGLEVWLPR-DRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPS 118

Query: 117 ---PTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGAS 173
                W+LVC       L Q  +++G LLG ++ G   DR GRR V + + + T   G  
Sbjct: 119 TIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTC 178

Query: 174 EALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLP 233
            A A +FP     RLL G  LAG  L      +E      R       G    +G  LL 
Sbjct: 179 AAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLA 238

Query: 234 GLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEAS 293
           G+A  V  WR LQ    L+S     F+ +   F ES  W  ++G++    + L R A  +
Sbjct: 239 GVAYAVPHWRHLQ---LLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARIN 295

Query: 294 GVGPGDSSLEENSLATA--TELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVG 351
           G     + L    L  +   ELTM   ++      S + LLR        L L       
Sbjct: 296 GKREEGAKLSMEVLRASLQKELTMGKGQA------SAMELLRCPTLRHLFLCLSMLWFAT 349

Query: 352 GGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLAS 411
                     L     + YL   +   ++  A +   L  +  GRRP  +   ++ G+  
Sbjct: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGIC- 408

Query: 412 LLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSS---LFAAEVFPTVIR 457
            +LL G   +P    +  + L +L    ++A  +   L+  E++PT+IR
Sbjct: 409 -ILLNGV--IPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR 454


>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
           sapiens]
          Length = 506

 Score =  100 bits (248), Expect = 5e-21
 Identities = 115/469 (24%), Positives = 181/469 (38%), Gaps = 38/469 (8%)

Query: 7   VLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRG 66
           +L+  GG GR +++  +   +P +++    + +    A P  HCRP      PA   L  
Sbjct: 6   LLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRP------PADANLSK 59

Query: 67  PALLDAAIPRLGPTRAPAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAG---------- 116
              L+  +PR      P   L   SP +  P       +   +      G          
Sbjct: 60  NGGLEVWLPR-DRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPS 118

Query: 117 ---PTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGAS 173
                W+LVC       L Q  +++G LLG ++ G   DR GRR V + + + T   G  
Sbjct: 119 TIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTC 178

Query: 174 EALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLP 233
            A A +FP     RLL G  LAG  L      +E      R       G    +G  LL 
Sbjct: 179 AAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLA 238

Query: 234 GLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEAS 293
           G+A  V  WR LQ    L+S     F+ +   F ES  W  ++G++    + L R A  +
Sbjct: 239 GVAYAVPHWRHLQ---LLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARIN 295

Query: 294 GVGPGDSSLEENSLATA--TELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVG 351
           G     + L    L  +   ELTM   ++      S + LLR        L L       
Sbjct: 296 GKREEGAKLSMEVLRASLQKELTMGKGQA------SAMELLRCPTLRHLFLCLSMLWFAT 349

Query: 352 GGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLAS 411
                     L     + YL   +   ++  A +   L  +  GRRP  +   ++ G+  
Sbjct: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGIC- 408

Query: 412 LLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSS---LFAAEVFPTVIR 457
            +LL G   +P    +  + L +L    ++A  +   L+  E++PT+IR
Sbjct: 409 -ILLNGV--IPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR 454


>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
          Length = 547

 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 112/425 (26%), Positives = 170/425 (40%), Gaps = 32/425 (7%)

Query: 109 SCSGAAAGPTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTT 168
           S S  +    W L+    +KV         G  +G +  G   DRFGR+ V++    L  
Sbjct: 91  SSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDI 150

Query: 169 GLGASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPH-RLAFSMGAGLFSVV 227
               +   + S+    V R L G    G  L  ++   E     +  LA S+G GLF  V
Sbjct: 151 LFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIG-GLFFAV 209

Query: 228 GTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILW 287
           G      L   ++ WR L  L  L   ++ L   F    PESP WL + G+++ A + L+
Sbjct: 210 GIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLF---IPESPRWLYSQGRLSEAEEALY 266

Query: 288 RFAEASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFS 347
             A+               L     LT  + RS +    S L L R RV   + LIL F 
Sbjct: 267 LIAK-----------RNRKLKCTFSLTHPANRSCR-ETGSFLDLFRYRVLLGHTLILMFI 314

Query: 348 SLVGGGIRASFRRSLAPQVPTFYLPYFLEAGLEAAA--LVFLLLTADCCGRRPVLLLGTM 405
             V   +      S      + Y    L   +E  +  L   L+     GR+  L     
Sbjct: 315 WFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLC 374

Query: 406 VTGLASLLLLAGAQYLPGW--TVLF-------LSVLGLLASRAVSALSSLFAAEVFPTVI 456
           + GLA L+++    +LP    T +F       LS+LG L   A   +  ++ +E++PTVI
Sbjct: 375 LGGLACLIVM----FLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVI 430

Query: 457 RGAGLGLVLGAGFLGQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLP 516
           R  GLG       +G    P         + L  +VF +  + + L  LLLPE+ +  L 
Sbjct: 431 RNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLL 490

Query: 517 QSLQD 521
           ++  D
Sbjct: 491 ETFSD 495


>gi|148664184 solute carrier family 22, member 10 [Homo sapiens]
          Length = 541

 Score = 90.5 bits (223), Expect = 4e-18
 Identities = 104/413 (25%), Positives = 174/413 (42%), Gaps = 14/413 (3%)

Query: 119 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 178
           W+LVC       + Q   L G L+G +I G   DRFGRR +    L+         A A 
Sbjct: 135 WDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCLLQLAITDTCAAFAP 194

Query: 179 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHR-LAFSMGAGLFSVVGTLLLPGLAA 237
           +FP   VLR L G +    +    L   E   P  + L   + +G  S +G ++L GLA 
Sbjct: 195 TFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGALS-IGQIILGGLAY 253

Query: 238 LVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGP 297
           + +DW   Q L  + S    +F+       ES  WL+ T ++    K L + A  +G+  
Sbjct: 254 VFRDW---QTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALRKVARTNGIKN 310

Query: 298 GDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRAS 357
            + +L    + +  +  + +A++      +   L R     +   IL F           
Sbjct: 311 AEETLNIEVVRSTMQEELDAAQTKT----TVCDLFRNPSMRKRICILVFLRFANTIPFYG 366

Query: 358 FRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAG 417
              +L       +L   L   +        LLT +  GRR   +L   + GL+ L     
Sbjct: 367 TMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSILANTFV 426

Query: 418 AQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGPL 477
            + +    V  L+ LG+  S A  +  ++   E+ PTV+R    G+ L A  +G A  PL
Sbjct: 427 PKEMQTLRVA-LACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGAALAPL 485

Query: 478 DTLHGRQGFF--LQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRS 528
             L     FF  L  +++    ++  L V LLPE+++  LP +++D +  +++
Sbjct: 486 --LMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQKKN 536


>gi|211059435 solute carrier family 22, member 24 [Homo sapiens]
          Length = 551

 Score = 89.7 bits (221), Expect = 6e-18
 Identities = 111/417 (26%), Positives = 175/417 (41%), Gaps = 22/417 (5%)

Query: 119 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAA 178
           W+LVC       + Q   + G LLG +I G   DR GR+ +     +         A A 
Sbjct: 135 WDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCFLQLAISNTCAAFAP 194

Query: 179 SFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAAL 238
           +F    +LR L G +    L   ++  LE   P  R    M       VG +LL GLA  
Sbjct: 195 TFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCSYSVGQMLLGGLAFA 254

Query: 239 VQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPG 298
           +QDW +LQ    + + +++LF     +  ES  WL+   Q+    K L R A  +G    
Sbjct: 255 IQDWHILQ--LTVSTPIIVLFLSSWKMV-ESARWLIINNQLDEGLKELRRVAHINGKKNT 311

Query: 299 DSSLEENSLATATELTMLSAR---SPQPRYHSPLGLLRTRVTW----RNGLILGFSSLVG 351
           + +L    + +  +  + + R   S    + +P   LR RV      R  + + F  L+ 
Sbjct: 312 EETLTTELVRSTMKKELDAVRIKTSIFSLFRAP--KLRMRVFGLCFVRFAITVPFYGLIL 369

Query: 352 GGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLAS 411
                   + L   V  F +   L   +   A    LLT +  GRR   +L T   GL  
Sbjct: 370 N------LQHLGSNVSLFQI---LCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFI 420

Query: 412 LLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLG 471
           L+     Q +    V+ L+ LG+ +  A S  +S+   E+ PT++R    G+   +G  G
Sbjct: 421 LVNTFLPQEMQILRVV-LATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTG 479

Query: 472 QAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRS 528
            A  PL          L  + +    +LA+  +LLLPE+R   LP ++QD +  + S
Sbjct: 480 AALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVENEKDS 536


>gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]
          Length = 332

 Score = 89.7 bits (221), Expect = 6e-18
 Identities = 95/315 (30%), Positives = 145/315 (46%), Gaps = 32/315 (10%)

Query: 215 LAFSMGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLL 274
           L FS G GL + V        A  V+DW LLQ + ++   L  L+  + A   ES  WLL
Sbjct: 18  LGFSFGHGLTAAV--------AYGVRDWTLLQLVVSVPFFLCFLYSWWLA---ESARWLL 66

Query: 275 ATGQVARARKILWRFAEASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLL-- 332
            TG++    + LWR A  +G G    +L    L +A    +   + P     + LG L  
Sbjct: 67  TTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPP-----ASLGTLLR 121

Query: 333 ------RTRVTWRNGLILGFSSLVGGGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVF 386
                 RT ++       GF+     G+    + +L   +  F L  F+   ++  A + 
Sbjct: 122 MPGLRFRTCISTLCWFAFGFTFF---GLALDLQ-ALGSNI--FLLQMFIGV-VDIPAKMG 174

Query: 387 LLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSL 446
            LL     GRRP L    ++ GL  +L      +  G     L+VLGL    A     ++
Sbjct: 175 ALLLLSHLGRRPTLAASLLLAGLC-ILANTLVPHEMGALRSALAVLGLGGVGAAFTCITI 233

Query: 447 FAAEVFPTVIRGAGLGLVLGAGFLGQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLL 506
           +++E+FPTV+R   +GL   A   G   GPL  L G  G +L  +V+ ++ VL+ L  LL
Sbjct: 234 YSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALL 293

Query: 507 LPESRSRGLPQSLQD 521
           LPE++S  LP ++QD
Sbjct: 294 LPETQSLPLPDTIQD 308


>gi|157426885 organic cation transporter like 4 [Homo sapiens]
          Length = 594

 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 126/562 (22%), Positives = 215/562 (38%), Gaps = 76/562 (13%)

Query: 5   ARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRAL 64
           A +L A G FG  ++ L + +++P I+    + ++  +     P+C              
Sbjct: 53  ANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCN------------- 99

Query: 65  RGPALLDAAIPRLGPTRAPAEALGVLSP-----SYLAPLTRAPRP-----------SSWA 108
                  + I  +GP  + AE L +  P     S+L      P P           +   
Sbjct: 100 ------TSWILAVGPHLSKAEQLNLTIPQAPNGSFLTCFMYLPVPWNLDSIIQFGLNDTD 153

Query: 109 SCSGAAAGP---------TWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAV 159
           +C      P          ++LVCG   K    Q+  + G  +G +I     D+ GR   
Sbjct: 154 TCQDGWIYPDAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPA 213

Query: 160 FVASLVLTTGLGASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSM 219
            + SL+     G   A   SF   L  R     ++ G  ++      E     HR    +
Sbjct: 214 ILLSLLGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAII 273

Query: 220 GAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQV 279
               F  VG +LL G+A  +  W+LL  +G +   L++ F  +  + PESP WL+  G+V
Sbjct: 274 LGHCFFAVGAVLLTGIAYSLPHWQLLFLVGGI---LVIPFISYIWILPESPRWLMMKGKV 330

Query: 280 ARARKILWRFAEASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWR 339
             A+++L   A  +      + L+E  L    ++T  S           L   + R   +
Sbjct: 331 KEAKQVLCYAASVNKKTIPSNLLDELQL-PRKKVTRASV----------LDFCKNRQLCK 379

Query: 340 NGLILGFSSLVGGGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRR-- 397
             L++            +    +     + +  + + + +E  A +  +      GR+  
Sbjct: 380 VTLVMSCVWFTVSYTYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWS 439

Query: 398 -PVLLLGTMVTGLASLLLLAG------------AQYLPGWTVLFLSVLGLLASRAVSALS 444
             V LL  ++  L  L L  G            A  L   T+L L +L   +  A   + 
Sbjct: 440 LAVTLLQAIIWCLLLLFLPEGEDGLRLKWPRCPATELKSMTILVL-MLREFSLAATVTVF 498

Query: 445 SLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCV 504
            L+ AE+ PTV+R  GLGLV  A   G       T+  +    L   +   LA++A    
Sbjct: 499 FLYTAELLPTVLRATGLGLVSLASVAGAILSL--TIISQTPSLLPIFLCCVLAIVAFSLS 556

Query: 505 LLLPESRSRGLPQSLQDADRLR 526
            LLPE+R + L +SL  + ++R
Sbjct: 557 SLLPETRDQPLSESLNHSSQIR 578


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.140    0.438 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,497,524
Number of Sequences: 37866
Number of extensions: 1123903
Number of successful extensions: 5048
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 44
Number of HSP's successfully gapped in prelim test: 103
Number of HSP's that attempted gapping in prelim test: 4825
Number of HSP's gapped (non-prelim): 219
length of query: 558
length of database: 18,247,518
effective HSP length: 107
effective length of query: 451
effective length of database: 14,195,856
effective search space: 6402331056
effective search space used: 6402331056
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.