BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo sapiens] (1188 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Hom... 2455 0.0 gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Hom... 2455 0.0 gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo sap... 2455 0.0 gi|163965366 nascent polypeptide-associated complex alpha subuni... 159 1e-38 gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 154 6e-37 gi|116284392 mucin 2 precursor [Homo sapiens] 148 3e-35 gi|160707881 formin 2 [Homo sapiens] 137 5e-32 gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 133 1e-30 gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens] 124 4e-28 gi|47132519 Ras association and pleckstrin homology domains 1 is... 122 2e-27 gi|189181724 proteoglycan 4 isoform D [Homo sapiens] 119 1e-26 gi|189181722 proteoglycan 4 isoform C [Homo sapiens] 119 1e-26 gi|189181720 proteoglycan 4 isoform B [Homo sapiens] 119 1e-26 gi|67190163 proteoglycan 4 isoform A [Homo sapiens] 119 1e-26 gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens] 110 1e-23 gi|110349719 titin isoform N2-A [Homo sapiens] 108 2e-23 gi|150170670 piccolo isoform 2 [Homo sapiens] 107 7e-23 gi|150378539 piccolo isoform 1 [Homo sapiens] 107 7e-23 gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [... 107 9e-23 gi|146219843 Snf2-related CBP activator protein [Homo sapiens] 105 3e-22 gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 103 1e-21 gi|122937496 WAS/WASL interacting protein family, member 3 [Homo... 103 1e-21 gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 101 5e-21 gi|110832843 TBP-associated factor 4 [Homo sapiens] 101 5e-21 gi|46852161 methyl-CpG binding domain protein 6 [Homo sapiens] 100 6e-21 gi|221139926 NHS-like 1 [Homo sapiens] 96 3e-19 gi|55750053 atrophin-1 [Homo sapiens] 96 3e-19 gi|55750041 atrophin-1 [Homo sapiens] 96 3e-19 gi|21361376 splicing factor 3a, subunit 2 [Homo sapiens] 95 3e-19 gi|153792074 proline rich 12 [Homo sapiens] 95 3e-19 >gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Homo sapiens] Length = 1188 Score = 2455 bits (6362), Expect = 0.0 Identities = 1188/1188 (100%), Positives = 1188/1188 (100%) Query: 1 MKKKQTVQGTFSKLFGKKHTTTPSTSLYATNPPWIFTQEAPEEGTGGFDGIYYGDNRFNT 60 MKKKQTVQGTFSKLFGKKHTTTPSTSLYATNPPWIFTQEAPEEGTGGFDGIYYGDNRFNT Sbjct: 1 MKKKQTVQGTFSKLFGKKHTTTPSTSLYATNPPWIFTQEAPEEGTGGFDGIYYGDNRFNT 60 Query: 61 VSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLR 120 VSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLR Sbjct: 61 VSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLR 120 Query: 121 LYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEP 180 LYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEP Sbjct: 121 LYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEP 180 Query: 181 PPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPA 240 PPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPA Sbjct: 181 PPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPA 240 Query: 241 SPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPR 300 SPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPR Sbjct: 241 SPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPR 300 Query: 301 SFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEP 360 SFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEP Sbjct: 301 SFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEP 360 Query: 361 DCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCA 420 DCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCA Sbjct: 361 DCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCA 420 Query: 421 QKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCG 480 QKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCG Sbjct: 421 QKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCG 480 Query: 481 SRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTET 540 SRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTET Sbjct: 481 SRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTET 540 Query: 541 EAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRI 600 EAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRI Sbjct: 541 EAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRI 600 Query: 601 CENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPA 660 CENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPA Sbjct: 601 CENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPA 660 Query: 661 TPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKP 720 TPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKP Sbjct: 661 TPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKP 720 Query: 721 ASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSR 780 ASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSR Sbjct: 721 ASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSR 780 Query: 781 EVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA 840 EVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA Sbjct: 781 EVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA 840 Query: 841 LLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPK 900 LLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPK Sbjct: 841 LLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPK 900 Query: 901 EAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPL 960 EAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPL Sbjct: 901 EAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPL 960 Query: 961 PKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDL 1020 PKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDL Sbjct: 961 PKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDL 1020 Query: 1021 RQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHG 1080 RQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHG Sbjct: 1021 RQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHG 1080 Query: 1081 GTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAPGSA 1140 GTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAPGSA Sbjct: 1081 GTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAPGSA 1140 Query: 1141 DYGFAPAAGRSPYTTTRYGSPINTFTVRPGTRHPISYVCSGAHRKATS 1188 DYGFAPAAGRSPYTTTRYGSPINTFTVRPGTRHPISYVCSGAHRKATS Sbjct: 1141 DYGFAPAAGRSPYTTTRYGSPINTFTVRPGTRHPISYVCSGAHRKATS 1188 >gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Homo sapiens] Length = 1188 Score = 2455 bits (6362), Expect = 0.0 Identities = 1188/1188 (100%), Positives = 1188/1188 (100%) Query: 1 MKKKQTVQGTFSKLFGKKHTTTPSTSLYATNPPWIFTQEAPEEGTGGFDGIYYGDNRFNT 60 MKKKQTVQGTFSKLFGKKHTTTPSTSLYATNPPWIFTQEAPEEGTGGFDGIYYGDNRFNT Sbjct: 1 MKKKQTVQGTFSKLFGKKHTTTPSTSLYATNPPWIFTQEAPEEGTGGFDGIYYGDNRFNT 60 Query: 61 VSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLR 120 VSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLR Sbjct: 61 VSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLR 120 Query: 121 LYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEP 180 LYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEP Sbjct: 121 LYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEP 180 Query: 181 PPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPA 240 PPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPA Sbjct: 181 PPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPA 240 Query: 241 SPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPR 300 SPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPR Sbjct: 241 SPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPR 300 Query: 301 SFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEP 360 SFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEP Sbjct: 301 SFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEP 360 Query: 361 DCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCA 420 DCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCA Sbjct: 361 DCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCA 420 Query: 421 QKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCG 480 QKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCG Sbjct: 421 QKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCG 480 Query: 481 SRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTET 540 SRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTET Sbjct: 481 SRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTET 540 Query: 541 EAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRI 600 EAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRI Sbjct: 541 EAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRI 600 Query: 601 CENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPA 660 CENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPA Sbjct: 601 CENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPA 660 Query: 661 TPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKP 720 TPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKP Sbjct: 661 TPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKP 720 Query: 721 ASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSR 780 ASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSR Sbjct: 721 ASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSR 780 Query: 781 EVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA 840 EVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA Sbjct: 781 EVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA 840 Query: 841 LLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPK 900 LLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPK Sbjct: 841 LLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPK 900 Query: 901 EAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPL 960 EAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPL Sbjct: 901 EAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPL 960 Query: 961 PKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDL 1020 PKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDL Sbjct: 961 PKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDL 1020 Query: 1021 RQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHG 1080 RQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHG Sbjct: 1021 RQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHG 1080 Query: 1081 GTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAPGSA 1140 GTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAPGSA Sbjct: 1081 GTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAPGSA 1140 Query: 1141 DYGFAPAAGRSPYTTTRYGSPINTFTVRPGTRHPISYVCSGAHRKATS 1188 DYGFAPAAGRSPYTTTRYGSPINTFTVRPGTRHPISYVCSGAHRKATS Sbjct: 1141 DYGFAPAAGRSPYTTTRYGSPINTFTVRPGTRHPISYVCSGAHRKATS 1188 >gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo sapiens] Length = 1188 Score = 2455 bits (6362), Expect = 0.0 Identities = 1188/1188 (100%), Positives = 1188/1188 (100%) Query: 1 MKKKQTVQGTFSKLFGKKHTTTPSTSLYATNPPWIFTQEAPEEGTGGFDGIYYGDNRFNT 60 MKKKQTVQGTFSKLFGKKHTTTPSTSLYATNPPWIFTQEAPEEGTGGFDGIYYGDNRFNT Sbjct: 1 MKKKQTVQGTFSKLFGKKHTTTPSTSLYATNPPWIFTQEAPEEGTGGFDGIYYGDNRFNT 60 Query: 61 VSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLR 120 VSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLR Sbjct: 61 VSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLR 120 Query: 121 LYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEP 180 LYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEP Sbjct: 121 LYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEP 180 Query: 181 PPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPA 240 PPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPA Sbjct: 181 PPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPA 240 Query: 241 SPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPR 300 SPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPR Sbjct: 241 SPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPR 300 Query: 301 SFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEP 360 SFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEP Sbjct: 301 SFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEP 360 Query: 361 DCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCA 420 DCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCA Sbjct: 361 DCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCA 420 Query: 421 QKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCG 480 QKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCG Sbjct: 421 QKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCG 480 Query: 481 SRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTET 540 SRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTET Sbjct: 481 SRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTET 540 Query: 541 EAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRI 600 EAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRI Sbjct: 541 EAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRI 600 Query: 601 CENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPA 660 CENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPA Sbjct: 601 CENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPA 660 Query: 661 TPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKP 720 TPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKP Sbjct: 661 TPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKP 720 Query: 721 ASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSR 780 ASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSR Sbjct: 721 ASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSR 780 Query: 781 EVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA 840 EVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA Sbjct: 781 EVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA 840 Query: 841 LLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPK 900 LLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPK Sbjct: 841 LLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPK 900 Query: 901 EAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPL 960 EAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPL Sbjct: 901 EAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPL 960 Query: 961 PKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDL 1020 PKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDL Sbjct: 961 PKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDL 1020 Query: 1021 RQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHG 1080 RQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHG Sbjct: 1021 RQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHG 1080 Query: 1081 GTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAPGSA 1140 GTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAPGSA Sbjct: 1081 GTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAPGSA 1140 Query: 1141 DYGFAPAAGRSPYTTTRYGSPINTFTVRPGTRHPISYVCSGAHRKATS 1188 DYGFAPAAGRSPYTTTRYGSPINTFTVRPGTRHPISYVCSGAHRKATS Sbjct: 1141 DYGFAPAAGRSPYTTTRYGSPINTFTVRPGTRHPISYVCSGAHRKATS 1188 >gi|163965366 nascent polypeptide-associated complex alpha subunit isoform a [Homo sapiens] Length = 2078 Score = 159 bits (403), Expect = 1e-38 Identities = 245/906 (27%), Positives = 307/906 (33%), Gaps = 188/906 (20%) Query: 139 IPPPPPGPA-PGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEAL 197 +P P GPA P P Q P SP P P + P P AP PP A Sbjct: 893 LPFPKEGPATPAPKQ---APALSMTSSSPKKARATPAPKGIPASPSPKGAPTPP----AA 945 Query: 198 SPPHTLSSPSIP------TPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFP 251 +PP P+ P TPP PP+P P P P P P SP P Sbjct: 946 TPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSP 1005 Query: 252 PGGVTKWKSDVALNGRQAEATRASPPRSPAE---PKGSALGPNPEPHLTFPRSFKVPPPT 308 G T T SP SPA PKG++ P P P P T Sbjct: 1006 KGAPT-----------PPAVTPPSPKGSPAATPFPKGASTPPAATP----PSPKGSPAAT 1050 Query: 309 PVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKA 368 P+ P A P + G + P PP+ P S P P A Sbjct: 1051 PL-PKGAPTTPAATLPSPKGGPATPSLKGAPTPPA--ATPPSPKGGPATPSPKGAPMPPA 1107 Query: 369 TAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPP--APPLPPAAPPLPCAQKAAHP 426 P SP+ G + TP PP P PPP AP P A PP P A P Sbjct: 1108 ATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPP 1167 Query: 427 PAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDR 486 P G TP ++ P+ K PSP+ ++ Sbjct: 1168 PKGAPTTPAATPPSPKGGLATPSPKGAPTT------------------------------ 1197 Query: 487 FLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSL 546 P P S +G G P + + PA TPP P+ L S P+ Sbjct: 1198 -------PAATPPSPKG--GLATPSPKGAPTTPAA-TPPS-PKGGLATPSPKGAPTTPAA 1246 Query: 547 TLPS-----VDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRIC 601 T PS P+ +PTP L+ L++ K A PP P+ GG Sbjct: 1247 TPPSPKGGPATPPPKGAPTPPA-ATPPSLKGGLATPPHKGAPNPAVVTPPSPK--GG--- 1300 Query: 602 ENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKAT-LWPA 660 S P PP +T P S G PP TP PK T PA Sbjct: 1301 ------PATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPP---SPKGTPTLPA 1351 Query: 661 TPPKATLGPATPLKATSGPTTPLKATS---GPAIASTATTLPTTTSQLMAEKDSGPAGQP 717 T P + GP TP + GPT P S GPA+ T S P G P Sbjct: 1352 TTPSSKGGPTTP-SSKEGPTPPAATPSHKGGPAM--------TPPSPKRGPAIPSPKGDP 1402 Query: 718 EKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSS 777 PA +S P +A E P++G + PP +P S Sbjct: 1403 TSPAVIPLS-PKKAPATPVTREGAATPSKGDLT----PPAVTP---------------VS 1442 Query: 778 LSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPA-KPPASAQPTDELLRHPVTGEVVERG 836 L + A P +GG A P K P LPA PP+ +P P +V Sbjct: 1443 LKKAPATSAP---KGGPATPSS----KGDPTLPAVTPPSPKEP-------PAPKQVATSS 1488 Query: 837 SPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEAS----SDSIFHSQGTPNSF 892 SP +K + A +G +LP + + A+ D I + + Sbjct: 1489 SP-----------KKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKK 1537 Query: 893 TVVPKLPKEAEKDSPLTTEIPNKWGPRL--GRDAEGTELSRRHNWTKPEPQAPVAWERVA 950 T PKEA +T P K P + ++A T S+ E +P A V Sbjct: 1538 TPATLAPKEALIPPAMTVPSPKK-TPAIPTPKEAPATPSSK-------EASSPPA---VT 1586 Query: 951 PSNLPQGHPLPKSFSSPP---SPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLG 1007 PS +G P PK PP SPS K E V PP PE P PAP G Sbjct: 1587 PSTY-KGAPSPKELLIPPAVTSPSPK----EAPTPPAVTPPSPE--KGPATPAPK----G 1635 Query: 1008 RQSSPP 1013 +SPP Sbjct: 1636 TPTSPP 1641 Score = 133 bits (334), Expect = 1e-30 Identities = 201/794 (25%), Positives = 284/794 (35%), Gaps = 185/794 (23%) Query: 60 TVSESGTATLKARPRVRP---LLTFLPLNAQENHGLAVPTP-----SVPDDFADKEVTGT 111 T S G T A P L T P A P+P + P A T Sbjct: 1211 TPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAAT 1270 Query: 112 SSLVNGNLRLYSSVGDLRPGQYGQDLLIPPPPP--GPAPGPPQDISEPPGGSPLPSPPST 169 + G L G P ++ PP P GPA PP+ PP +P PSP + Sbjct: 1271 PPSLKGGLATPPHKGAPNPA------VVTPPSPKGGPATSPPKGAPTPPAATP-PSPKGS 1323 Query: 170 APPPPPLLLEPPPPPSMAPPPP---PVLEALSP-----PHTLSSPSIPTPPDFIPPAPPL 221 PPP P PP++ PP P P L A +P P T SS PTPP P Sbjct: 1324 PGTPPP--KGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGG 1381 Query: 222 AFLAPPPP------PVPAPAPPAPA--------SPHTVGTRLFPPGGVTKWKSDVALNGR 267 + PP P P P P +PA +P T TR G T K D+ Sbjct: 1382 PAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTR---EGAATPSKGDLTPPAV 1438 Query: 268 QAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKE 327 + + +P S PKG P+ + T P V PP+P +E P + Sbjct: 1439 TPVSLKKAPATS--APKGGPATPSSKGDPTLP---AVTPPSP-----------KEPPAPK 1482 Query: 328 EGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPA--SPRLGQSQSQADE 385 + AT +P + P P+ P A P P E+ AT + P + + + Sbjct: 1483 QVATSSSPKKAPATPAPMGAPTLP-----AVIPSSPKEVPATPSSRRDPIAPTATLLSKK 1537 Query: 386 RAGTPPPAPPLPPPAPPLP----PPAPPLPPAAPPLPCAQKAAHPPAGFTKT-------- 433 T P L PPA +P PA P P AP P +++A+ PPA T Sbjct: 1538 TPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPK 1597 Query: 434 -----PKSSSPALKPKPNP--------------PSPENTASSAPVDWRDPSQMEKLRNEL 474 P +SP+ K P P P+P+ T +S PV PS ++ Sbjct: 1598 ELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPV---TPSSLKDSPTSP 1654 Query: 475 AAYLCGSRREDRFLSHRPGPTVAPQSKEG---KKGPRLPEKETLLSLPAKDTPPGVPEKS 531 A+ C + G TV PQ+ +G KKGP KE L++ PA ++ P + + Sbjct: 1655 ASVTC-----------KMGATV-PQASKGLPAKKGP-TALKEVLVA-PAPESTPIITAPT 1700 Query: 532 LGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPP 591 G ++ A P P PS A+ +K + ++ P Sbjct: 1701 RKGPQTKKSSATS----------PPICPDPS---------------AKNGSKGPLSTVAP 1735 Query: 592 KPRLEGGRICENGA-DDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGP----------- 639 P L + A D P PP+S P T+ + +L Sbjct: 1736 APLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPS 1795 Query: 640 ---AIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSG----PTTPLKATSGPA-I 691 ++P +P P +PPK P++P P+ PL P P + SG Sbjct: 1796 PPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPISGGVPF 1855 Query: 692 ASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPS------------E 739 S +PT S AG P S + +G G+ S + Sbjct: 1856 QSVLVNMPTPKS----------AGIPVPTPSAKQPVTKNNKGSGTESDSDESVPELEEQD 1905 Query: 740 ATRLPTQGARSSAA 753 +T+ TQ A+ +AA Sbjct: 1906 STQATTQQAQLAAA 1919 Score = 130 bits (328), Expect = 6e-30 Identities = 192/723 (26%), Positives = 250/723 (34%), Gaps = 119/723 (16%) Query: 138 LIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPP---PVL 194 L PPP G P P GG PSP P P P P +A P P P Sbjct: 1163 LATPPPKGAPTTPAATPPSPKGGLATPSPKGA--PTTPAATPPSPKGGLATPSPKGAPTT 1220 Query: 195 EALSPPHT---LSSPS---IPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTR 248 A +PP L++PS PT P PP+P PPP AP PPA P G Sbjct: 1221 PAATPPSPKGGLATPSPKGAPTTPAATPPSPKGG--PATPPPKGAPTPPAATPPSLKGGL 1278 Query: 249 LFPP-GGVTKWKSDVALNGRQAEATRASPPR--------SPAEPKGSALGPNPEPHLTFP 299 PP G + + AT SPP+ +P PKGS P P+ T P Sbjct: 1279 ATPPHKGAPNPAVVTPPSPKGGPAT--SPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPP 1336 Query: 300 RSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPE 359 V PP+P T ++P P + G T + P PP A Sbjct: 1337 ---AVTPPSPKGTPTLPA----TTPSSKGGPTTPSSKEGPTPP--------------AAT 1375 Query: 360 PDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPC 419 P G A P SP+ G PA P P P P P P AP P Sbjct: 1376 PSHKGG-PAMTPPSPKRG--------------PAIPSPKGDPTSPAVIPLSPKKAPATPV 1420 Query: 420 AQKAAHPPAGFTKTPKSSSP-ALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYL 478 ++ A P+ TP + +P +LK P +P+ + P DP+ L A Sbjct: 1421 TREGAATPSKGDLTPPAVTPVSLKKAPATSAPKG-GPATPSSKGDPT--------LPAVT 1471 Query: 479 CGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPA------KDTP--PGVPEK 530 S +E P P S KK P P +LPA K+ P P Sbjct: 1472 PPSPKEP------PAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRD 1525 Query: 531 SLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLP 590 + ++ ++ P+ P IP PS ++ + + E A PS Sbjct: 1526 PIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKK-----TPAIPTPKEAPATPSSKEAS 1580 Query: 591 PKPRLEGGRICENGADDDK-LSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIP-PKATP- 647 P + GA K L P A P P P GPA P PK TP Sbjct: 1581 SPPAVTPSTY--KGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPT 1638 Query: 648 -EPAIPPKATLWPATPPKAT--LGPATP-----LKATSGPTTPLKATSGPAIASTATTLP 699 P P P +P T +G P L A GPT + PA P Sbjct: 1639 SPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPA--------P 1690 Query: 700 TTTSQLMAEKDSGPAGQPEKPASQEV-STPSQARGEGSP----SEATRLPTQ--GARSSA 752 +T + A GP + S + PS G P + A LP Q ++++ Sbjct: 1691 ESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAK 1750 Query: 753 AFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVK-EPPGLPA 811 SP G P K ++ + E + P A AA P PV + P +P Sbjct: 1751 GKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAA-PSPPVSLPLAPSPVPT 1809 Query: 812 KPP 814 PP Sbjct: 1810 LPP 1812 Score = 120 bits (302), Expect = 6e-27 Identities = 186/735 (25%), Positives = 253/735 (34%), Gaps = 116/735 (15%) Query: 138 LIPPPPPGPAPGPPQDISEPPGGSPLPSP---PST--APPPPPLLLEPPPPPSMAPPP-- 190 L P P G P P GG PSP P+T A PP P PPP AP P Sbjct: 1209 LATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPA 1268 Query: 191 --PPVLEA--LSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPH-TV 245 PP L+ +PPH P P PP+P PP P P P SP + Sbjct: 1269 ATPPSLKGGLATPPH----KGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSP 1324 Query: 246 GTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVP 305 GT PP G + + + A+ P S P + P P P P Sbjct: 1325 GTP--PPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGP 1382 Query: 306 ---PPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDC 362 PP+P R +IP + + +P + P P A+ D P Sbjct: 1383 AMTPPSPKRGPAIP---SPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVT 1439 Query: 363 PGEL-KATAPASPRLGQSQSQADERAGTPPPAPPLP--PPAP--------PLPPPAPPLP 411 P L KA A ++P+ G + + P PP P PPAP P PA P P Sbjct: 1440 PVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAP 1499 Query: 412 PAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLR 471 AP LP ++ P TP S + P S + A+ AP + P M Sbjct: 1500 MGAPTLPAVIPSS--PKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTV-- 1555 Query: 472 NELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKS 531 P P P K+ P P S A P P Sbjct: 1556 --------------------PSPKKTPAIPTPKEAPATPS-----SKEASSPPAVTPSTY 1590 Query: 532 LGGSSLTETEAAPSLTLPSVDYIPQDSPT-PSVRQIRNELEARLSSAAEKEAKPSI--GS 588 G S E P++T PS P+++PT P+V E + P + S Sbjct: 1591 KGAPSPKELLIPPAVTSPS----PKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSS 1646 Query: 589 LPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPE 648 L P C+ GA + SK + P T+L+ + ++ PA P++TP Sbjct: 1647 LKDSPTSPASVTCKMGATVPQASKGLPAKKGP--------TALK-EVLVAPA--PESTPI 1695 Query: 649 PAIP----PKATLWPATPPKATLGPATPLKATSGPTTPLKATS-GPAIASTATTLPTTTS 703 P P+ AT P P+ A +G PL + P + + T Sbjct: 1696 ITAPTRKGPQTKKSSATSPPICPDPS----AKNGSKGPLSTVAPAPLLPVQKDSSKTAKG 1751 Query: 704 QLMAEKDSGPAGQPEKPASQEVST---------PSQARGEGSPSEATRLPTQGARSSAAF 754 + + GP PE AS ++ P A +PS LP Sbjct: 1752 KDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPL-APSPVPTL 1810 Query: 755 PPK-----TSPG-GGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEP-- 806 PPK +SPG E P + L + ++ P GG P + V V P Sbjct: 1811 PPKQQFLPSSPGLVLESPSKPLAPADEDEL---LPLIPPEPISGGV--PFQSVLVNMPTP 1865 Query: 807 --PGLPAKPPASAQP 819 G+P P++ QP Sbjct: 1866 KSAGIPVPTPSAKQP 1880 Score = 107 bits (266), Expect = 9e-23 Identities = 260/1056 (24%), Positives = 349/1056 (33%), Gaps = 190/1056 (17%) Query: 165 SPPSTAPPPPPLLLEPPPPPSMAP--PPPPVLEALSPPHTLSSPSIPTPPDF--IPPAPP 220 SPP ++ P + P MAP P P + + SP +P P D +P + Sbjct: 464 SPPMSSGPISNIEPTSPAALVMAPVAPKEPSTQVATTLRIPVSPPLPDPEDLKNLPSSVL 523 Query: 221 LAFLAPPP-PPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASP--P 277 + F VPA AP SP G V N ++T +SP P Sbjct: 524 VKFPTQKDLQTVPASLEGAPFSPAQAGLTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEIP 583 Query: 278 RSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSR 337 SP P P + P TS + V + + + A + Sbjct: 584 LSPEATLAKKSLGEPLP---------IGKPASSMTSPLGVNSSASVIKTDSYAGPDSAG- 633 Query: 338 LPLPPSFHIRPASQVYPDRAPEP------DCPGELKATAPASPRLGQSQSQADE----RA 387 PL S I P +P + +P G T ASP L + S A + + Sbjct: 634 -PLLKSSLITPTVAAFPLESADPAGVAPTTAKGTSTYTTTASPFLEGTVSLAPKNHPVKE 692 Query: 388 GTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKS-SSPALKPKPN 446 GT P L P A P AP +P CA A A + PKS SP+L P Sbjct: 693 GTLTTLP-LVPTASENCPVAP-----SPQNTCAPLATLVLA--PEIPKSVPSPSLPPAGT 744 Query: 447 PPSPE------NTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGP------ 494 PP + +T++ APV P + + A+ S+ +L+ P P Sbjct: 745 PPGTKKVDGISHTSALAPVA-SSPKECPT-EDSGASATASSKGTLTYLADSPSPLGVSVS 802 Query: 495 --TVAPQSKEGKKGPRLPEKETLLSLPAKDTPPG-VPEKSLGGSSLTETEAAPSLTLPSV 551 T P +K+G GP P LS P +PE SL S ++ +P+ T Sbjct: 803 PQTKRPPTKKGSAGPDTPIGN--LSSPVSPVEASFLPENSL---SFQGSKDSPATTHSPT 857 Query: 552 DYIPQDSPTPSVRQIRNELEARLSSAAEKEAK-PSIGSLP-PKPRLEGGRICENGADDDK 609 P+ +PTPS L + + KE PS+ +LP PK EG Sbjct: 858 PPSPKGAPTPSAV---TPLSPKGVTLPPKETPTPSVVNLPFPK---EGP----------- 900 Query: 610 LSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPA-TPPKATLG 668 A P Q+ L T+S KA PA PK P P A PA TPP G Sbjct: 901 -----ATPAPKQAPALSMTSSSPKKARATPA--PKGIPASPSPKGAPTPPAATPPSPKGG 953 Query: 669 PATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTP 728 PATP + TP AT AT P A P G P P+ + TP Sbjct: 954 PATP--SPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTP 1011 Query: 729 ---SQARGEGSPSEATRLPTQGARSSAAFPP--KTSPGGGEVPCLYKPHCHQSSLSREVA 783 + +GSP+ AT P + AA PP K SP +P A Sbjct: 1012 PAVTPPSPKGSPA-ATPFPKGASTPPAATPPSPKGSPAATPLP---------KGAPTTPA 1061 Query: 784 VVMPTLARGGAAGP---GEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA 840 +P+ +GG A P G P P P PA+ P +G+PM Sbjct: 1062 ATLPS-PKGGPATPSLKGAPTPPAATPPSPKGGPATPSP---------------KGAPMP 1105 Query: 841 LLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPK 900 A + G + G + P + A+ +G P + P PK Sbjct: 1106 PA-ATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPP----KGAPTTPAATPPSPK 1160 Query: 901 EAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPL 960 L T P K P T S + P P+ AP+ P Sbjct: 1161 GG-----LATP-PPKGAPTT---PAATPPSPKGGLATPSPKG-------APTTPAATPPS 1204 Query: 961 PKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDL 1020 PK + PSP PP P+ P+P ++PP Sbjct: 1205 PKGGLATPSPKGAPTTPA------ATPPSPK--GGLATPSPKGAPTTPAATPPS------ 1250 Query: 1021 RQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRG------ 1074 P GP PP G PA + GGL PH+G Sbjct: 1251 ---PKGGPATPPPKGAPTPPAATPPSLKGGL----------------ATPPHKGAPNPAV 1291 Query: 1075 --PGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPRLSLEGAARGAAEA 1132 P P GG + S P P S G PP G P + +G Sbjct: 1292 VTPPSPKGGP--ATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTL 1349 Query: 1133 KHKAPGSADYGFAPAAGRSP----YTTTRYGSPINT 1164 P S P++ P T + G P T Sbjct: 1350 PATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMT 1385 Score = 97.8 bits (242), Expect = 5e-20 Identities = 229/1014 (22%), Positives = 332/1014 (32%), Gaps = 177/1014 (17%) Query: 192 PVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPV-PAPAPPAPASPHTVGTRLF 250 P ++ +S H+ + S P+ IPP P + P P AP P T+ + Sbjct: 334 PTVKTISVDHSSTGASYPSQRSVIPPLPSRNEVVPATVAAFPVVAPSVDKGPSTISSITC 393 Query: 251 PPGGVTKWKSDVALNGRQAEATRASPPRS-----PAEPKGSALGPNP-----------EP 294 P G + +L+ + ++SP + A+ S++G P P Sbjct: 394 SPSGSLNVATSFSLSPTTSLILKSSPNATYHYPLVAQMPVSSVGTTPLVVTNPCTIAAAP 453 Query: 295 HLTFPRSFKVPPP------------TPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPP 342 TF + V PP +P PV A + P + T + P PLP Sbjct: 454 TTTFEVATCVSPPMSSGPISNIEPTSPAALVMAPV--APKEPSTQVATTLRIPVSPPLPD 511 Query: 343 SFHIR--PASQV--YPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPP 398 ++ P+S + +P + P L+ AP SP +QA P PL Sbjct: 512 PEDLKNLPSSVLVKFPTQKDLQTVPASLEG-APFSP------AQAGLTTKKDPTVLPLVQ 564 Query: 399 PAPPLPPP-----APPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENT 453 AP P + P P +P A+K+ P P KP + SP Sbjct: 565 AAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPL----------PIGKPASSMTSPLGV 614 Query: 454 ASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPT-VAPQSKEGKKG---PRL 509 SSA V D L + F P VAP + +G Sbjct: 615 NSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKGTSTYTTTAS 674 Query: 510 PEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNE 569 P E +SL K+ P V E +L L T + PS PQ++ P + Sbjct: 675 PFLEGTVSLAPKNHP--VKEGTLTTLPLVPTASENCPVAPS----PQNTCAPLATLV--- 725 Query: 570 LEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTT 629 L + + + P G+ P +++G I A S P K P + + T Sbjct: 726 LAPEIPKSVPSPSLPPAGTPPGTKKVDG--ISHTSALAPVASSP--KECPTEDSGASATA 781 Query: 630 SLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGP 689 S + G +P P L + P+ P K ++GP TP+ S P Sbjct: 782 SSK-----GTLTYLADSPSP-------LGVSVSPQTKRPPTK--KGSAGPDTPIGNLSSP 827 Query: 690 AIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGAR 749 A+ LP + KDS PA+ TP +G +PS T L +G Sbjct: 828 VSPVEASFLPENSLSFQGSKDS--------PATTHSPTPPSPKGAPTPSAVTPLSPKG-- 877 Query: 750 SSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGL 809 PPK +P V + + ++ + T ++ P + P G+ Sbjct: 878 --VTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMT-----SSSPKKARATPAPKGI 930 Query: 810 PAKPPASAQPTDELLRHPVTGEVVERGSP--MALLLAARQRAQKGRSVGAALGRSSLPGS 867 PA P PT P SP AA + KG + + P + Sbjct: 931 PASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPA 990 Query: 868 LRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRDAEGT 927 S + ++ S +G P V P P K SP T P +G Sbjct: 991 ATPPSPKGGPATPS---PKGAPTPPAVTPPSP----KGSPAATPFP-----------KGA 1032 Query: 928 ELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPS---PSNKREEEEEEFNFE 984 T P P +P P PLPK + P+ PS K Sbjct: 1033 S-------TPPAATPP------SPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGA 1079 Query: 985 VIPP---PPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPA 1041 PP PP P P+P + ++PP P G PP G PA Sbjct: 1080 PTPPAATPPSPKGGPATPSPKGAPMPPAATPPS---------PKGGLATPPHKGAPTTPA 1130 Query: 1042 GARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHGGTGRSLSSPNCFGPQPGGPEM 1101 + GGL G P P P GG L++P P G P Sbjct: 1131 ATPPSPKGGLATPPPKGAPT--------TPAATPPSPKGG----LATP----PPKGAPTT 1174 Query: 1102 RRVNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAPGSADYGFAPAAGRSPYTT 1155 +P GGL P + +GA P S G A + + TT Sbjct: 1175 PAATPP--SPKGGLATP------SPKGAPTTPAATPPSPKGGLATPSPKGAPTT 1220 Score = 82.8 bits (203), Expect = 2e-15 Identities = 262/1131 (23%), Positives = 369/1131 (32%), Gaps = 144/1131 (12%) Query: 131 GQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPP 190 GQ G L PPP PAP +S SP PSP + A P LE P P S + Sbjct: 39 GQPGPTL---PPPCSPAP-QQCPLSAANQASPFPSPSTIASTP----LEVPFPQSSSGTA 90 Query: 191 PPVLEALSPPHTLSSPSIPTPPDFIPPA------PPLAFLAPPPPPVPAPAPPAPASPHT 244 P+ A P L P++ PP I PA P +A P AP +PH+ Sbjct: 91 LPLGTAPEAPTFL--PNLIGPP--ISPAALALASPMIAPTLKGTPSSSAPLALVALAPHS 146 Query: 245 V-GTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFK 303 V + FPP +T S VA+ S P +P+EPK + N P P Sbjct: 147 VQKSSAFPPNLLTSPPS-VAV-AESGSVITLSAPIAPSEPKTNL---NKVPSEVVPNPKG 201 Query: 304 VPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRA-----P 358 P P P S++P + G S P+ + AS D Sbjct: 202 TPSP-PCIVSTVPYHCVTPMASIQSGVA----SLPQTTPTTTLAIASPQVKDTTISSVLI 256 Query: 359 EPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLP 418 P PG L P SP S S + P A P PP P+ + P Sbjct: 257 SPQNPGSLSLKGPVSPPAALSLS-----TQSLPVVTSSQKTAGPNTPPDFPISLGSHLAP 311 Query: 419 CAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAP----VDWRDPSQMEKLRNEL 474 Q + +T S+ K +T +S P V PS+ E + + Sbjct: 312 LHQSSFGSVQLLGQTGPSALSDPTVKTISVDHSSTGASYPSQRSVIPPLPSRNEVVPATV 371 Query: 475 AAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPG-------- 526 AA+ + D+ S T +P T SL K +P Sbjct: 372 AAFPVVAPSVDKGPSTISSITCSPSGSLNVATSFSLSPTT--SLILKSSPNATYHYPLVA 429 Query: 527 -VPEKSLGGSSLTETE-----AAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSA--A 578 +P S+G + L T AAP+ T + + + I A L A A Sbjct: 430 QMPVSSVGTTPLVVTNPCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTSPAALVMAPVA 489 Query: 579 EKEAKPSIGS---LPPKPRLEGGRICENGADDDKLSKPVAKNLP--PQSTTLLP------ 627 KE + + +P P L +N + P K+L P S P Sbjct: 490 PKEPSTQVATTLRIPVSPPLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFSPAQA 549 Query: 628 --TTSLQPKAMLGPAIPPKATP---EPAIPPKATLWP-ATPPKATLGPATPL-KATSGPT 680 TT P + PK +P + P+ L P AT K +LG P+ K S T Sbjct: 550 GLTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMT 609 Query: 681 TPLKATSGPAIASTATTL-PTTTSQLMAEKDSGP--AGQPEKPASQEVSTPSQARGEGSP 737 +PL S ++ T + P + L+ P A P + A P+ A+G Sbjct: 610 SPLGVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKG---T 666 Query: 738 SEATRLPTQGARSSAAFPPKTSP-GGGEVPCL-----YKPHCHQSSLSREVAVVMPTLAR 791 S T + + + PK P G + L +C + + + TL Sbjct: 667 STYTTTASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTCAPLATL-- 724 Query: 792 GGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVE--RGSPMALLLAARQRA 849 P P V P PA P + D + V + P A+ + Sbjct: 725 --VLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATAS 782 Query: 850 QKGRSVGAA-----LGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPK---- 900 KG A LG S P + R + + A D+ + +P S LP+ Sbjct: 783 SKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLS 842 Query: 901 -EAEKDSPLTTEIPNKWGPR--------LGRDAEGTELSRRHNWTKPEPQAPVAWERVAP 951 + KDSP TT P P+ +G L + T P E A Sbjct: 843 FQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPAT 902 Query: 952 SNLPQGHPLPKSFSSP----PSPSNKREEEEEEFNFEVIPP---PPEFSNDPEPPAPALQ 1004 Q L + SSP +P+ K PP PP P P+P Sbjct: 903 PAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWA 962 Query: 1005 YLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGR---SL 1061 ++PP P GP P G PA + GG S G Sbjct: 963 PTPPAATPPS---------PKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPA 1013 Query: 1062 IKKRLYVGEPHRGPGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPRLS 1121 + G P P P G + ++P P P G +A P G P + Sbjct: 1014 VTPPSPKGSPAATP-FPKGASTPPAATP----PSPKGSP-----AATPLPKGAPTTPAAT 1063 Query: 1122 LEGAARGAAEAKHKAPGSADYGFAPAAGRSPYTTTRYGSPINTFTVRPGTR 1172 L G A K + P+ P T + G+P+ P + Sbjct: 1064 LPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPK 1114 Score = 57.4 bits (137), Expect = 8e-08 Identities = 204/948 (21%), Positives = 304/948 (32%), Gaps = 201/948 (21%) Query: 167 PSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAP 226 P A P + P P P+ ALS L P PT P PAP L+ Sbjct: 2 PGEATETVPATEQELPQPQAETAVLPMSSALSVTAALGQPG-PTLPPPCSPAPQQCPLSA 60 Query: 227 PPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGS 286 P P+P AS T L P + + + L G EA P + Sbjct: 61 ANQASPFPSPSTIAS-----TPLEVPFPQSSSGTALPL-GTAPEAPTFLP---------N 105 Query: 287 ALGPNPEP-HLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFH 345 +GP P L P +SS P+ AP + ++ P+ L PPS Sbjct: 106 LIGPPISPAALALASPMIAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVA 165 Query: 346 IRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPP 405 + + V AP AP+ P+ ++ P+ +P P Sbjct: 166 VAESGSVITLSAP----------IAPSEPKTNLNK----------VPSEVVPNPK---GT 202 Query: 406 PAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPS 465 P+PP + P C A +G P+++ +P + T SS + ++P Sbjct: 203 PSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTTTLAIASPQVKDTTISSVLISPQNPG 262 Query: 466 QMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPP 525 + L+ ++ S LS + P V K GP P + +SL + P Sbjct: 263 SL-SLKGPVSPPAALS------LSTQSLPVVTSSQKTA--GPNTP-PDFPISLGSHLAP- 311 Query: 526 GVPEKSLGGSSLTETEAAPSLTLP-----SVDYIPQDSPTPSVRQIRNELEAR-----LS 575 + + S G L +L+ P SVD+ + PS R + L +R + Sbjct: 312 -LHQSSFGSVQLLGQTGPSALSDPTVKTISVDHSSTGASYPSQRSVIPPLPSRNEVVPAT 370 Query: 576 SAAEKEAKPSIGSLP---------PKPRLEGGRICENGADDDKLSK---------PVAKN 617 AA PS+ P P L + K P+ Sbjct: 371 VAAFPVVAPSVDKGPSTISSITCSPSGSLNVATSFSLSPTTSLILKSSPNATYHYPLVAQ 430 Query: 618 LP-------------PQSTTLLPTTSLQPKAMLGPAIP--PKATPEPAIPPKATLWPATP 662 +P P + PTT+ + + P + P + EP P + P P Sbjct: 431 MPVSSVGTTPLVVTNPCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTSPAALVMAPVAP 490 Query: 663 PKATLGPATPLKATSGPTTP----LK-------------------------ATSGPAIAS 693 + + AT L+ P P LK A PA A Sbjct: 491 KEPSTQVATTLRIPVSPPLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFSPAQAG 550 Query: 694 TATTL-PTTTSQLMAEKDSGPAGQ-----PEKPASQEVSTPSQARGE----GSPSEATRL 743 T PT + A + P+ Q PE P S E + ++ GE G P+ + Sbjct: 551 LTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMTS 610 Query: 744 PTQGARSSAAFPPKTSPGGGE------VPCLYKPHCHQSSL-SREVAVVMPTLARG---- 792 P G SSA+ S G + L P L S + A V PT A+G Sbjct: 611 PL-GVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKGTSTY 669 Query: 793 ------------GAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA 840 A PV+ LP P AS PV +P+A Sbjct: 670 TTTASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASE-------NCPVAPSPQNTCAPLA 722 Query: 841 LLLAARQRAQKGRS-----VGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVV 895 L+ A + + S G G + G + ASS ++ + S T Sbjct: 723 TLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATAS 782 Query: 896 PK--LPKEAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSN 953 K L A+ SPL + P+ + P + A + Sbjct: 783 SKGTLTYLADSPSPLGVSV------------------------SPQTKRPPTKKGSAGPD 818 Query: 954 LPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAP 1001 P G + SSP SP E +F+ P ++ P PP+P Sbjct: 819 TPIG-----NLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSP 861 >gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens] Length = 1124 Score = 154 bits (388), Expect = 6e-37 Identities = 229/808 (28%), Positives = 302/808 (37%), Gaps = 156/808 (19%) Query: 139 IPPPPPGPAPGPPQDISEPPGGSPLP-SPPSTAPPPPPLLLEPPP-------PPSMAPPP 190 +PPP P P PP +PLP +PPS + PP L PP PPSM PP Sbjct: 317 VPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPP 376 Query: 191 ---PPVLEALSP---PHTLSSPSIPTPP-----------------------DFIPPAPPL 221 PP L+ + P PH+L+SPS+ PP F+ +P Sbjct: 377 MQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQ 436 Query: 222 AFLAPPPPPVPAPAPP----------APASPHTVGTRLFPPGGVTKWKSDVALNGRQAEA 271 + P PA PP PASP + T L P V+ S + ++ QA + Sbjct: 437 TQASLTSPSRPASTPPDSPPLQAPLSLPASP-PLQTSLSP--AVSPLSSPLTIHPLQALS 493 Query: 272 TRASPPRSPAEPKGSALGPNPE-------PHL-TFPRSFKVPP--------PTPVRTSSI 315 + AS SP P S + P E P L T P S PP P P++T+S Sbjct: 494 SLAS--HSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASA 551 Query: 316 PVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAP---- 371 P+ P E AP L PPS P P P+ P + P Sbjct: 552 PL----TTPHLETPPC-PAPCPLQAPPS----------PLTTPPPETPSSIATPPPQAPP 596 Query: 372 --ASPRLGQSQSQADERAGTPPP-APP---LPP-PAPPLPPPAPPLPPAAPPLPCAQKA- 423 ASP L S TPPP APP LPP APP PP +PPL P A P P A A Sbjct: 597 ALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNAL 656 Query: 424 AHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRR 483 A +P S P P P SP + S+ P PS LAA Sbjct: 657 AVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPS--------LAA------- 701 Query: 484 EDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAA 543 L P P +P P P+ L+ P PP P S T Sbjct: 702 --PPLQVPPSPPASPPMSPSATPP--PQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRV 757 Query: 544 PSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICEN 603 P L +P P+P + L A A P + +LP P G+ + Sbjct: 758 PPLLAAPPLQVP---PSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFS 814 Query: 604 GADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPP 663 + +S P+A PPQ+ +L LQ +PP P + +A P TP Sbjct: 815 PSASLPMS-PLA-TPPPQAPPVLAAPLLQ--------VPPSPPASPTL--QAPRRPPTPG 862 Query: 664 KAT--LGPATPLKATSGP-----TTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAG- 715 T GP L GP +P SGP +A +++ +T +L DSGP G Sbjct: 863 PDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRG-YDSGPEGG 921 Query: 716 -QPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSS-AAFPPKTSPGGGEVPC-LYKPH 772 P E++ A P A L +GA + +PP T PG + C +Y+ Sbjct: 922 AAASPPPDAELAACHPAAWSRGP--APPLAFRGAPGAPLPWPPATGPGSADGLCTIYETE 979 Query: 773 CHQSSLSREVAV---VMPTLARG-GAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPV 828 +S+ A+ P + G AAG G G ++ P A+ EL + Sbjct: 980 GPESATPAPGALDPGPSPGTSGGKAAAGAG--------AGASSRSPKQAR-LGELPLGAL 1030 Query: 829 TGEVVERGSPMALLLAARQRAQKGRSVG 856 VV+ LLLAA + A G G Sbjct: 1031 QASVVQHLLSRTLLLAAAEGAAGGSGGG 1058 Score = 124 bits (310), Expect = 7e-28 Identities = 190/758 (25%), Positives = 266/758 (35%), Gaps = 136/758 (17%) Query: 158 PGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDF--- 214 P P P+ P P L+ PP + PP AL P LSS + TP Sbjct: 257 PSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGP---LSSSPLATPSPSGTK 313 Query: 215 ---IPP----APPLAFLAPPPPPVPAP---APPAPASPHTVGTRLFPPGGVTKWKSDVAL 264 +PP A PL PP PP+ P APP+P++P ++ T PP A Sbjct: 314 ARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPP----------AT 363 Query: 265 NGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAP 324 QA + +PP A P + P PH S + PP+P+ SS+ + +P Sbjct: 364 PPSQAPPSMTTPPMQ-APPSLQTIPPIQVPHSLTSPSLQA-PPSPLALSSLQATTSLGSP 421 Query: 325 RKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQAD 384 + AT + P + S+ P P P + + PASP L S S A Sbjct: 422 TLQ--ATHSFLTMSPRQTQASLTSPSR--PASTPPDSPPLQAPLSLPASPPLQTSLSPAV 477 Query: 385 ERAGTPPPAPPL---------PPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPK 435 +P PL P AP PPL + P + + PPA T P Sbjct: 478 SPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQT--PPASLTTPPL 535 Query: 436 SSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPT 495 + P+L P P TAS+ P L C L P P Sbjct: 536 ENLPSL-----APPPLQTASA-------PLTTPHLETPPCPAPCP-------LQAPPSPL 576 Query: 496 VAPQSKEGKKGPRLPEKETLLSLPAKDTPP--------GVPEKSLGGSSLTETEAAPSLT 547 P PE + ++ P PP G+P L + +A P L Sbjct: 577 TTPP----------PETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLA 626 Query: 548 LPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADD 607 LP + P +P + + + +A + S PP P ++ Sbjct: 627 LPPLQAPPSPPASPPLSPLATP-SPQAPNALAVHLLQAPFSPPPSPPVQA---------- 675 Query: 608 DKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGP-AIPPKATPEPAIPPKATLWPATPPKAT 666 S P + PP S + P + P P +PP P + P AT P PP Sbjct: 676 -PFSPPAS---PPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLA 731 Query: 667 LGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVS 726 A PL+ P + P ++ +AT P L A P P PAS +S Sbjct: 732 ---APPLQVPPSP------PASPPMSPSATPPPRVPPLLAAPPLQVP---PSPPASLPMS 779 Query: 727 TPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVM 786 ++ + P+ AT P Q S PP + PG Q+ S ++ M Sbjct: 780 PLAKPPPQAPPALATP-PLQALPS----PPASFPG-------------QAPFSPSASLPM 821 Query: 787 PTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVT--GEVVERGSPMALLLA 844 LA P PV +P PPAS PT + R P T + G + L LA Sbjct: 822 SPLATPPPQAP--PVLAAPLLQVPPSPPAS--PTLQAPRRPPTPGPDTSVSGPRLTLALA 877 Query: 845 ARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSI 882 RS + L L G HS A ++ + + Sbjct: 878 PGPPPPPSRSPSSTLSGPDLAG----HSSSATSTPEEL 911 Score = 119 bits (298), Expect = 2e-26 Identities = 277/1177 (23%), Positives = 374/1177 (31%), Gaps = 259/1177 (22%) Query: 130 PGQYGQDLLIPPPPPGPAPGPP-----------------QDISEPPGGSPLPSPPSTAPP 172 P LL P PP P P PP + ++E GG + P +AP Sbjct: 17 PAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPR 76 Query: 173 PPPL----------LLEPP-------PPPSMAPPPPPVLEALSPPHTLSSPSIPTP---- 211 P PP PP+ P PV S P S + P P Sbjct: 77 AGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPV----SSPGRASGTTRPGPLGQK 132 Query: 212 --------------PDFIPPAPPLAFLAPPPPPVPAPAPPAPA---SPHTVGTRLFPPGG 254 P L+ A P P P+PA GT + P Sbjct: 133 GLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRP 192 Query: 255 VTKWKSDVALNGRQAEATRAS-----PPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTP 309 + G + + AS P A + SA G P S P +P Sbjct: 193 APSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSP 252 Query: 310 VRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKAT 369 R+ A+ PR ++ P L +RP QV P R G L ++ Sbjct: 253 ARSG----PSARGTPRAPAHPSQPKPKGLQA-----LRP-PQVTPPRKDAAPALGPLSSS 302 Query: 370 APASPRLGQSQSQ---ADERAGTPPPA--PPLPPPAPPLP--PPAPPLPPAAP--PLPCA 420 A+P ++++ + A TP PA PP PP A PLP PP+P PP+ P P A Sbjct: 303 PLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPA 362 Query: 421 QKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCG 480 + P T P + P+L+ P P + S + P + L+ + Sbjct: 363 TPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPT 422 Query: 481 SRREDRFLSHRPGPTVA---PQSKEGKKGPRLPEKETLLSLPAK-----DTPPGV----- 527 + FL+ P T A S+ P P + LSLPA P V Sbjct: 423 LQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSS 482 Query: 528 -----------------PEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNEL 570 P+ L + E SL PS+ P TP + + + Sbjct: 483 PLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLA 542 Query: 571 EARLSSAAEKEAKPSIGSLP-PKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTT 629 L +A+ P + + P P P C A L+ P PP++ + + T Sbjct: 543 PPPLQTASAPLTTPHLETPPCPAP-------CPLQAPPSPLTTP-----PPETPSSIATP 590 Query: 630 SLQ-PKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSG 688 Q P A+ P P + P P + P AT P PP L PL+A P + Sbjct: 591 PPQAPPALASP--PLQGLPSPPLSPLATPPPQAPPXLAL---PPLQAPPSP------PAS 639 Query: 689 PAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGA 748 P ++ AT P + L P P P Q +P P Sbjct: 640 PPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSP---------------PASPP 684 Query: 749 RSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPG 808 S +A PP +P P L P +S + P A A P P++V PP Sbjct: 685 VSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP--PLQV--PPS 740 Query: 809 LPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSL---- 864 PA PP S T P L A Q S A+L S L Sbjct: 741 PPASPPMSPSATP---------------PPRVPPLLAAPPLQVPPSPPASLPMSPLAKPP 785 Query: 865 ---PGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLG 921 P +L QA S + F Q P P + SPL T Sbjct: 786 PQAPPALATPPLQALPSPPASFPGQ--------APFSPSASLPMSPLAT----------- 826 Query: 922 RDAEGTELSRRHNWTKPEPQAPVAWE----RVAPSNLPQGHPLPKSFSSPPSPSNKREEE 977 P PQAP +V PS P P ++ PP+P Sbjct: 827 ----------------PPPQAPPVLAAPLLQVPPS--PPASPTLQAPRRPPTPGPDTSVS 868 Query: 978 EEEFNFEVIP-PPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLRQL---PNAGPGAPP- 1032 + P PPP S P G SS + +LR P G A P Sbjct: 869 GPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSS-ATSTPEELRGYDSGPEGGAAASPP 927 Query: 1033 ---------ALGFSRFPA-GARYAGAGGL----ERFSGGGRSLIKKRLYVGE------PH 1072 +SR PA + GA G +G G + +Y E P Sbjct: 928 PDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPA 987 Query: 1073 RG---PGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHA-------PRLSL 1122 G PG G +G ++ G P+ R+ G P G L A R L Sbjct: 988 PGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARL---GELPLGALQASVVQHLLSRTLL 1044 Query: 1123 EGAARGAAEAKHKAPGSADYGFAPAAGRSPYTTTRYG 1159 AA GAA PG A+ G R+ + G Sbjct: 1045 LAAAEGAAGGSGGGPGGAEGGGVTGGARAALSDAELG 1081 Score = 117 bits (293), Expect = 7e-26 Identities = 147/497 (29%), Positives = 188/497 (37%), Gaps = 86/497 (17%) Query: 73 PRVRPL---LTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLRLYSSVGDLR 129 P V PL LT PL A + LA +P P SSL+ L SS+ Sbjct: 475 PAVSPLSSPLTIHPLQALSS--LASHSPQAP----------LSSLIMPPLETQSSLAPPS 522 Query: 130 PGQYGQDLLIPPPP--PGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMA 187 L PP P AP P Q S P L +PP AP P L+ PP P + Sbjct: 523 LQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCP----LQAPPSP-LT 577 Query: 188 PPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVP--APAPPAPASPHTV 245 PPP +++ P + P++ +PP P+PPL+ LA PPP P PP A P Sbjct: 578 TPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPS-- 635 Query: 246 GTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSP-AEPKGSALGPNPEPHLTFPRSFKV 304 PP ASPP SP A P A PN F Sbjct: 636 -----PP---------------------ASPPLSPLATPSPQA--PNALAVHLLQAPFSP 667 Query: 305 PPPTPVRT-----SSIPVQEAQEAPRKEEGATKKAPSRL-PLPPSFHIRPASQVYPDRAP 358 PP PV+ +S PV + P + + P ++ P PP+ S P +AP Sbjct: 668 PPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAP 727 Query: 359 EPDC--PGELKATAPASPRLGQSQSQADERAGTPPPAPPL----PPPAPPLPPPAPPLPP 412 P P ++ + PASP + S A PP PPL P PP PP + P+ P Sbjct: 728 PPLAAPPLQVPPSPPASPPMSPS-------ATPPPRVPPLLAAPPLQVPPSPPASLPMSP 780 Query: 413 AAPPLPCAQKA-AHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLR 471 A P P A A A PP +P PA P P SP + +P+ P L Sbjct: 781 LAKPPPQAPPALATPPLQALPSP----PASFPGQAPFSPSASLPMSPLATPPPQAPPVLA 836 Query: 472 NELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPG-VPEK 530 L + R PT P + GPRL TL P PP P Sbjct: 837 APLLQVPPSPPASPTLQAPRRPPTPGPDT--SVSGPRL----TLALAPGPPPPPSRSPSS 890 Query: 531 SLGGSSLTETEAAPSLT 547 +L G L ++ + T Sbjct: 891 TLSGPDLAGHSSSATST 907 Score = 98.6 bits (244), Expect = 3e-20 Identities = 128/445 (28%), Positives = 167/445 (37%), Gaps = 68/445 (15%) Query: 73 PRVRPLLTFLPLNAQEN---HGLAVPTPSVPDDFADKEVTGTSSL-VNGNLRLYSSVGDL 128 P+ P L PL + LA P P P A + S + L ++ Sbjct: 592 PQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQ 651 Query: 129 RPGQYGQDLLIPP--PPPGPAPGPPQDISEPPGGSPLPSPPSTAPPP---PPLLLEPPPP 183 P LL P PPP P P P SP +PPS APP PPL + P PP Sbjct: 652 APNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPP 711 Query: 184 PSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPP----APPLAFLAPPPPPVP--APAPP 237 S PP+ + +PP + P + PP +PP +PP++ A PPP VP APP Sbjct: 712 AS-----PPMSPSATPPPQ-APPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPP 765 Query: 238 APASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPP-RSPAEPKGSALGPNP-EPH 295 P PP + S +A QA A+PP ++ P S G P P Sbjct: 766 LQVPPS-------PPASLP--MSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPS 816 Query: 296 LTFPRS-FKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPP----------SF 344 + P S PPP + P+ Q P T +AP R P P + Sbjct: 817 ASLPMSPLATPPPQAPPVLAAPL--LQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTL 874 Query: 345 HIRPASQVYPDRAPE-----PDCPG-ELKATAPASPRLGQSQSQADERAGTPPPAPPLPP 398 + P P R+P PD G AT+ G A +PPP L Sbjct: 875 ALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAA 934 Query: 399 --PAPPLPPPAPPLP-PAAPPLPCAQKAAHPPAGF--------TKTPKSSSP---ALKPK 444 PA PAPPL AP P A P T+ P+S++P AL P Sbjct: 935 CHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPG 994 Query: 445 PNPPSPENTASS---APVDWRDPSQ 466 P+P + A++ A R P Q Sbjct: 995 PSPGTSGGKAAAGAGAGASSRSPKQ 1019 Score = 82.0 bits (201), Expect = 3e-15 Identities = 171/709 (24%), Positives = 232/709 (32%), Gaps = 103/709 (14%) Query: 376 LGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPL--------------PCAQ 421 + + +A A PA P P PP +P PP P P A+ Sbjct: 1 MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE 60 Query: 422 KAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGS 481 +A G P+S+ A + S N AS P R + +N + Sbjct: 61 RAG--GIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRG-ERAPPAKNTSPGPVSSP 117 Query: 482 RREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTP----------------- 524 R + RPGP G+KG R+ +ET+ A + P Sbjct: 118 GRASG--TTRPGPL-------GQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPT 168 Query: 525 PGVPEKSLG-GSSLTETEAAPSLTLPSV-DYIPQDSPTPSVRQIRNELEARLSSAAEKEA 582 PG P ++ S TE PS P + P SV S AA + Sbjct: 169 PGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARR-- 226 Query: 583 KPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPK-----AML 637 +PS G +P R + A LS P + T P QPK A+ Sbjct: 227 RPSAGGGLQRP---ASRSLSSSA--TPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALR 281 Query: 638 GPAI-PPKATPEPAIPPKATLWPATP-PKATLGPATPLKATSGPTTPLKATSGPAIASTA 695 P + PP+ PA+ P ++ ATP P T A P+ TPL AT P+ A Sbjct: 282 PPQVTPPRKDAAPALGPLSSSPLATPSPSGT--KARPVPPPDNAATPLPATLPPS-PPLA 338 Query: 696 TTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFP 755 T LP P P+ Q + +P +P T P Q S P Sbjct: 339 TPLPL-----------APPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIP 387 Query: 756 PKTSPGGGEVPCLYKP--HCHQSSLSREVAVVMPTLARGGA---AGPGEPVEVKEPPGLP 810 P P P L P SSL ++ PTL + P + P P Sbjct: 388 PIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRP 447 Query: 811 AKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRD 870 A P + P L P + + SP L++ +++ SL Sbjct: 448 ASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQAL----------SSLAS 497 Query: 871 HSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRDAEGTELS 930 HS QA SS I T +S A +P +P+ P L L+ Sbjct: 498 HSPQAPLSS-LIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPL--QTASAPLT 554 Query: 931 RRHNWTKPEP-----QAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEV 985 H T P P QAP + P P P + P S + + Sbjct: 555 TPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPL 614 Query: 986 IPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPAL 1034 PPP+ PP AL L SPP + L L P AP AL Sbjct: 615 ATPPPQ-----APPXLALPPLQAPPSPPAS--PPLSPLATPSPQAPNAL 656 >gi|116284392 mucin 2 precursor [Homo sapiens] Length = 5179 Score = 148 bits (373), Expect = 3e-35 Identities = 165/677 (24%), Positives = 226/677 (33%), Gaps = 94/677 (13%) Query: 141 PPPPGPAPGPPQDISEPPGGSPLP------SPPSTAPPPPPLLLEPPPPPSMAPPPPPVL 194 PP P+P P + PP +P P +PP T P PP+ PPP+ P PP Sbjct: 1401 PPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPPTTTPSPPIST 1460 Query: 195 EALSPPHTLSSPSIPTP-PDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPG 253 PP T SP TP P P+PP PPP P+PP T + PP Sbjct: 1461 TTTPPPTTTPSPPTTTPSPPTTTPSPPTT-TTTTPPPTTTPSPPTT-------TPITPP- 1511 Query: 254 GVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTS 313 A T P +P+ P + P P + P + + PPT T+ Sbjct: 1512 ---------------ASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPT--STT 1554 Query: 314 SIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPAS 373 ++P P T P+ P PP+ P+ P P T + Sbjct: 1555 TLPPTTTPSPP--PTTTTTPPPTTTPSPPT-TTTPSPPTITTTTPPPTTTPSPPTTTTTT 1611 Query: 374 PRLGQSQSQADERAGTPPPA-PPLPPPAPPLPPPAPPL--PPAAPPLPCAQKAAHPPAGF 430 P + S TPP + LPP P PPP PP P P PP Sbjct: 1612 PPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITT 1671 Query: 431 TKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSH 490 T TP ++ P PSP T + P PS ++ S + Sbjct: 1672 TTTPPPTTTPSSPITTTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTPSPPPTTMTT- 1730 Query: 491 RPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPS 550 P PT P P T+ +LP T + L S T + S T P+ Sbjct: 1731 -PSPTTTPS----------PPTTTMTTLPPTTTSSPLTTTPLPPSITPPTFSPFSTTTPT 1779 Query: 551 VDYIP-------QDSPTPSVRQIRNELE-----------ARLSSAAEKEAKPSIGSLPPK 592 +P DS P+ + + E A +S A IG L Sbjct: 1780 TPCVPLCNWTGWLDSGKPNFHKPGGDTELIGDVCGPGWAANISCRATMYPDVPIGQLGQT 1839 Query: 593 P--RLEGGRICENGADDDKLSKPVAKNL-----------PPQSTTLLPTTSLQPKAMLGP 639 + G IC+N P+A L Q TT+ TT+ P Sbjct: 1840 VVCDVSVGLICKNEDQKPGGVIPMAFCLNYEINVQCCECVTQPTTMTTTTTENPTPPTTT 1899 Query: 640 AIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTP----------LKATSGP 689 I T P P T P T P T TP +G TP + T P Sbjct: 1900 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 1959 Query: 690 AIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGAR 749 T TT P TT+ + + P G + P + ++T + +P+ T Sbjct: 1960 TGTQTPTTTPITTTTTVTPTPT-PTG-TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 2017 Query: 750 SSAAFPPKTSPGGGEVP 766 ++ P +P G + P Sbjct: 2018 TTTTVTPTPTPTGTQTP 2034 Score = 104 bits (259), Expect = 6e-22 Identities = 140/686 (20%), Positives = 215/686 (31%), Gaps = 81/686 (11%) Query: 140 PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPS--MAPPP-----PP 192 P PP P PP + P + PSPP+T PP P PP + + PP PP Sbjct: 1578 PSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPP 1637 Query: 193 VLEALSPPHTLSSP---SIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRL 249 PP T ++P + P+PP P+PP+ PPP P+ P +P T + Sbjct: 1638 TTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPIT-TTTTPPPTTTPSSPITTTPSPPTTTM 1696 Query: 250 FPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTP 309 P T S + + T SPP + P+P P T +P Sbjct: 1697 TTPSPTTTPSSPITTTTTPSSTTTPSPPPTTMTTPSPTTTPSP-PTTTMTTLPPTTTSSP 1755 Query: 310 VRTSSIPVQEAQEAPRKEEGATKKAPSRLPL----------PPSFHIRP----------- 348 + T+ +P T P +PL P+FH +P Sbjct: 1756 LTTTPLPPSITPPTFSPFSTTTPTTPC-VPLCNWTGWLDSGKPNFH-KPGGDTELIGDVC 1813 Query: 349 ----ASQVYPDRAPEPDCP-GELKATAPASPRLGQSQSQADERAG--------------- 388 A+ + PD P G+L T +G D++ G Sbjct: 1814 GPGWAANISCRATMYPDVPIGQLGQTVVCDVSVGLICKNEDQKPGGVIPMAFCLNYEINV 1873 Query: 389 ------TPPPAPPLPPPAPPLPPPAPPL--PPAAPPLPCAQKAAHPPAGFTKTPKSSSPA 440 T P P PP P+ P P P T TP +++ Sbjct: 1874 QCCECVTQPTTMTTTTTENPTPPTTTPITTTTTVTPTPTPTGTQTP----TTTPITTTTT 1929 Query: 441 LKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQS 500 + P P P + T ++ P+ ++ P PT Sbjct: 1930 VTPTPTPTGTQ-TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT----- 1983 Query: 501 KEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPT 560 G + P T ++ TP G + + +T T P+ P +P Sbjct: 1984 --GTQTPTTTPITTTTTVTPTPTPTGTQTPTT--TPITTTTTVTPTPTPTGTQTPTTTPI 2039 Query: 561 PSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPP 620 + + + + ++ P P G + + V P Sbjct: 2040 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ--TPTTTPITTTTTVTPTPTP 2097 Query: 621 QSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPT 680 T TT + + P P T P P T TP G TP T Sbjct: 2098 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2157 Query: 681 TPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEA 740 T + T P T TT P TT+ + + P G + P + ++T + +P+ Sbjct: 2158 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPT-PTG-TQTPTTTPITTTTTVTPTPTPTGT 2215 Query: 741 TRLPTQGARSSAAFPPKTSPGGGEVP 766 T ++ P +P G + P Sbjct: 2216 QTPTTTPITTTTTVTPTPTPTGTQTP 2241 Score = 86.3 bits (212), Expect = 2e-16 Identities = 98/442 (22%), Positives = 133/442 (30%), Gaps = 84/442 (19%) Query: 331 TKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTP 390 T P+ P PP P S P P T P + + T Sbjct: 1398 TPSPPTTTPSPP-----PTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPPTT 1452 Query: 391 PPAPPL------PPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPK 444 P+PP+ PP P PP P PP P P PP T +P +++P P Sbjct: 1453 TPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPA 1512 Query: 445 PNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGK 504 P T S P + P PT P Sbjct: 1513 STTTLPPTTTPSPPTT---------------------------TTTTPPPTTTPSPPTTT 1545 Query: 505 KGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVR 564 P P T P T P P + T T + P+ T PS I +P P+ Sbjct: 1546 --PITPPTSTTTLPPT--TTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTT 1601 Query: 565 QIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTT 624 + P+ + P P + P+ P +TT Sbjct: 1602 P----------------SPPTTTTTTPPPTT---------TPSPPTTTPITP--PTSTTT 1634 Query: 625 LLPTTSLQPKAMLGPAIPPKATPEP--AIPPKATLWPATPPKATLGPATPLKATSGPTTP 682 L PTT+ P PP TP P P + T P T P++P+ T P T Sbjct: 1635 LPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTT 1694 Query: 683 LKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEA-T 741 T P ++ TTT + P ++TPS P+ T Sbjct: 1695 TMTTPSPTTTPSSPITTTTTPS---------STTTPSPPPTTMTTPSPTTTPSPPTTTMT 1745 Query: 742 RLP---TQGARSSAAFPPKTSP 760 LP T ++ PP +P Sbjct: 1746 TLPPTTTSSPLTTTPLPPSITP 1767 Score = 85.9 bits (211), Expect = 2e-16 Identities = 98/399 (24%), Positives = 121/399 (30%), Gaps = 82/399 (20%) Query: 389 TPPPAPPLPPPA-----PPLPPPAPPL------PPAAPPLPCAQKAAHPPAGFTKTPKSS 437 +PP P PPP PP P+PP PP P P PP T +P S Sbjct: 1400 SPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPPTTTPSPPIS 1459 Query: 438 SPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVA 497 + P PSP T S P P + P PT Sbjct: 1460 TTTTPPPTTTPSPPTTTPSPPTTTPSPPTTT--------------------TTTPPPTTT 1499 Query: 498 PQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQD 557 P P T ++ PA T +P + T T P T PS Sbjct: 1500 PS----------PPTTTPITPPASTTT--LPPTTTPSPPTTTTTTPPPTTTPSPPTTTPI 1547 Query: 558 SPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKN 617 +P S L P+ + PP S P Sbjct: 1548 TPPTST--------TTLPPTTTPSPPPTTTTTPPPTTTP--------------SPPTTTT 1585 Query: 618 LPPQS---TTLLPTTSLQPKAMLGPAIPPKATPE-----PAIPPKA--TLWPATPPKATL 667 P + TT PTT+ P PP TP P PP + TL P T P Sbjct: 1586 PSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPP 1645 Query: 668 GPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVST 727 T T+ P+ P T P I +T T PTTT S P P + ++T Sbjct: 1646 TTTTTPPPTTTPSPPTTTTPSPPITTTTTPPPTTT-------PSSPITTTPSPPTTTMTT 1698 Query: 728 PSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVP 766 PS SP T P+ S T+P P Sbjct: 1699 PSPTTTPSSPITTTTTPSSTTTPSPPPTTMTTPSPTTTP 1737 Score = 84.7 bits (208), Expect = 5e-16 Identities = 109/485 (22%), Positives = 137/485 (28%), Gaps = 99/485 (20%) Query: 173 PPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVP 232 P + P PP+ P PPP PP T SP T PPP Sbjct: 1391 PMDKCITTPSPPTTTPSPPPTSTTTLPPTTTPSPPTTT--------------TTTPPPTT 1436 Query: 233 APAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNP 292 P+PP + T PP T T PP + P + P+P Sbjct: 1437 TPSPP-------ITTTTTPPPTTTP--------SPPISTTTTPPPTTTPSPPTTT--PSP 1479 Query: 293 EPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQV 352 P + P P T S P P T P+ P PP+ + Sbjct: 1480 PTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPAS---TTTLPPTTTPSPPT-----TTTT 1531 Query: 353 YPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPP---APP 409 P P P T P S PP P PPP PP P Sbjct: 1532 TPPPTTTPSPPTTTPITPPTSTTT------------LPPTTTPSPPPTTTTTPPPTTTPS 1579 Query: 410 LPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEK 469 P P P PP T +P +++ P PSP T P P+ Sbjct: 1580 PPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITP-----PTSTTT 1634 Query: 470 LRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPE 529 L PT P T + P T P P Sbjct: 1635 LP----------------------PTTTPSPPP-----------TTTTTPPPTTTPSPPT 1661 Query: 530 KSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSL 589 + +T T P T PS SP P+ SS PS + Sbjct: 1662 TTTPSPPITTTTTPPPTTTPSSPITTTPSP-PTTTMTTPSPTTTPSSPITTTTTPSSTTT 1720 Query: 590 PPKPRLEGGRICENGADDDKLSKPVAK--NLPPQSTTLLPTTSLQPKAMLGPAIPPKATP 647 P P + S P LPP +T+ TT+ P ++ P P +T Sbjct: 1721 PSPPPTT----MTTPSPTTTPSPPTTTMTTLPPTTTSSPLTTTPLPPSITPPTFSPFSTT 1776 Query: 648 EPAIP 652 P P Sbjct: 1777 TPTTP 1781 Score = 81.6 bits (200), Expect = 4e-15 Identities = 110/459 (23%), Positives = 142/459 (30%), Gaps = 83/459 (18%) Query: 258 WKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPV 317 W D + T SPP + P+P T P P+ T++ P Sbjct: 1390 WPMDKCITTPSPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPP 1449 Query: 318 QEAQEAP------RKEEGATKKAPSRLPLPPSFHIRP--ASQVYPDRAPEPDCPGELKAT 369 +P T P+ P PP+ P + P P P T Sbjct: 1450 PTTTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPIT 1509 Query: 370 APASPRL---GQSQSQADERAGTPPP-APPLPPPAPPLPPP--APPLPPAAPPLPCAQKA 423 PAS + S TPPP P PP P+ PP LPP P P Sbjct: 1510 PPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSP----- 1564 Query: 424 AHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRR 483 PP T P +++P+ P PSP ++ P PS Sbjct: 1565 --PPTTTTTPPPTTTPS-PPTTTTPSPPTITTTTPPPTTTPS------------------ 1603 Query: 484 EDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAA 543 + P PT P P P T P T P P + T T + Sbjct: 1604 PPTTTTTTPPPTTTPSPP--TTTPITPPTSTTTLPPT--TTPSPPPTTTTTPPPTTTPSP 1659 Query: 544 PSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICEN 603 P+ T PS +P P+ S + P+ P P Sbjct: 1660 PTTTTPSPPITTTTTPPPTT--------TPSSPITTTPSPPTTTMTTPSPTTTP------ 1705 Query: 604 GADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPP 663 S P+ P STT T S P M P+ P TP P TL PP Sbjct: 1706 -------SSPITTTTTPSSTT---TPSPPPTTMTTPS--PTTTPSPPTTTMTTL----PP 1749 Query: 664 KATLGPATPLKATSGPTTPL-KATSGPAIASTATTLPTT 701 T P T TTPL + + P + +TT PTT Sbjct: 1750 TTTSSPLT--------TTPLPPSITPPTFSPFSTTTPTT 1780 Score = 79.3 bits (194), Expect = 2e-14 Identities = 145/795 (18%), Positives = 233/795 (29%), Gaps = 55/795 (6%) Query: 60 TVSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNL 119 TV+ + T T P P+ T + PTP+ +T T+++ Sbjct: 3562 TVTPTPTPTGTQTPTTTPITTTTTVTP-------TPTPTGTQTPTTTPITTTTTVTPTPT 3614 Query: 120 RLYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSP-----PSTAPPPP 174 + P + P P G I+ +P P+P P+T P Sbjct: 3615 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3674 Query: 175 PLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAP 234 + P P P+ P + P T ++ PTP P + P P Sbjct: 3675 TTTVTPTPTPTGTQTPT------TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3728 Query: 235 APPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALG---PN 291 P +P T P T G Q T + P + G P Sbjct: 3729 TPTGTQTPTTT-----PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3783 Query: 292 PEPHLTFPRSFKVPPPTPVRT-SSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPAS 350 P T P PT +T ++ P+ + P+ P+ + + P Sbjct: 3784 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3843 Query: 351 QVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPL 410 + P P T +P +Q+ T P P P P P+ Sbjct: 3844 TPTGTQTPTTT-PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 3902 Query: 411 PPAAP--PLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQME 468 P P P T TP +++ + P P P + T ++ P+ Sbjct: 3903 TTTTTVTPTPTPTGTQTP----TTTPITTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPT 3957 Query: 469 KLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVP 528 ++ P PT G + P T ++ TP G Sbjct: 3958 PTPTGTQTPTTTPITTTTTVTPTPTPT-------GTQTPTTTPITTTTTVTPTPTPTGTQ 4010 Query: 529 EKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGS 588 + + +T T P+ P +P + + + + + Sbjct: 4011 TPTT--TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 4068 Query: 589 LPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPE 648 + P P G + + V P T TT + + P P T Sbjct: 4069 VTPTPTPTGTQTPTT--TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 4126 Query: 649 PAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAE 708 P P T TP G TP TT + T P T TT P TT+ + Sbjct: 4127 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP 4186 Query: 709 KDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCL 768 + P G P + + P +P + P +S+ T+ + Sbjct: 4187 TPT-PTGTQTGPPTHTSTAPIAELTTSNPPPESSTPQTSRSTSSPLTESTT-----LLST 4240 Query: 769 YKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAK---PPASAQPTDELLR 825 P +S + PT GG P PPG P + +S+ PT ++ Sbjct: 4241 LPPAIEMTSTAPPSTPTAPTTTSGGHTLSPPPSTTTSPPGTPTRGTTTGSSSAPTPSTVQ 4300 Query: 826 HPVTGEVVERGSPMA 840 T +P++ Sbjct: 4301 TTTTSAWTPTPTPLS 4315 Score = 74.3 bits (181), Expect = 6e-13 Identities = 140/698 (20%), Positives = 220/698 (31%), Gaps = 72/698 (10%) Query: 60 TVSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNL 119 TV+ + T T P P+ T + PTP+ +T T+++ Sbjct: 3677 TVTPTPTPTGTQTPTTTPITTTTTVTP-------TPTPTGTQTPTTTPITTTTTVTPTPT 3729 Query: 120 RLYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSP-----PSTAPPPP 174 + P + P P G I+ +P P+P P+T P Sbjct: 3730 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3789 Query: 175 PLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAP 234 + P P P+ P + P T ++ PTP P + P P Sbjct: 3790 TTTVTPTPTPTGTQTPT------TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3843 Query: 235 APPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALG---PN 291 P +P T P T G Q T + P + G P Sbjct: 3844 TPTGTQTPTTT-----PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3898 Query: 292 PEPHLTFPRSFKVPPPTPVRT-SSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPAS 350 P T P PT +T ++ P+ + P+ P+ + + P Sbjct: 3899 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3958 Query: 351 QVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPL 410 + P P T +P +Q+ T P P P P P+ Sbjct: 3959 TPTGTQTPTTT-PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 4017 Query: 411 PPAAP--PLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQME 468 P P P T TP +++ + P P P + T ++ P+ Sbjct: 4018 TTTTTVTPTPTPTGTQTP----TTTPITTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPT 4072 Query: 469 KLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVP 528 ++ P PT G + P T ++ TP G Sbjct: 4073 PTPTGTQTPTTTPITTTTTVTPTPTPT-------GTQTPTTTPITTTTTVTPTPTPTGTQ 4125 Query: 529 EKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGS 588 + + +T T P+ P +P + + + + + Sbjct: 4126 TPTT--TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 4183 Query: 589 LPPKPRLEGGRICENGADDDKLSKPVAK----NLPPQSTTLLPTTSLQPKAMLGPAIPPK 644 + P P G + G + P+A+ N PP+S+T P TS + L + Sbjct: 4184 VTPTPTPTG---TQTGPPTHTSTAPIAELTTSNPPPESST--PQTSRSTSSPLTESTTLL 4238 Query: 645 ATPEPAIPPKATLWPATP--PKATLGPAT----PLKATSGPTTPLKATS-GPAIASTATT 697 +T PAI +T P+TP P T G T P TS P TP + T+ G + A T +T Sbjct: 4239 STLPPAIEMTSTAPPSTPTAPTTTSGGHTLSPPPSTTTSPPGTPTRGTTTGSSSAPTPST 4298 Query: 698 LPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEG 735 + TTT+ P +STPS R G Sbjct: 4299 VQTTTTSAWT------------PTPTPLSTPSIIRTTG 4324 Score = 73.2 bits (178), Expect = 1e-12 Identities = 171/927 (18%), Positives = 270/927 (29%), Gaps = 78/927 (8%) Query: 60 TVSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNL 119 TV+ + T T P P+ T + PTP+ +T T+++ Sbjct: 3447 TVTPTPTPTGTQTPTTTPITTTTTVTP-------TPTPTGTQTPTTTPITTTTTVTPTPT 3499 Query: 120 RLYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSP-----PSTAPPPP 174 + P + P P G I+ +P P+P P+T P Sbjct: 3500 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3559 Query: 175 PLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAP 234 + P P P+ P + P T ++ PTP P + P P Sbjct: 3560 TTTVTPTPTPTGTQTPT------TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3613 Query: 235 APPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALG---PN 291 P +P T P T G Q T + P + G P Sbjct: 3614 TPTGTQTPTTT-----PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3668 Query: 292 PEPHLTFPRSFKVPPPTPVRT-SSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPAS 350 P T P PT +T ++ P+ + P+ P+ + + P Sbjct: 3669 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3728 Query: 351 QVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPL 410 + P P T +P +Q+ T P P P P P+ Sbjct: 3729 TPTGTQTPTTT-PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 3787 Query: 411 PPAAP--PLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQME 468 P P P T TP +++ + P P P + T ++ P+ Sbjct: 3788 TTTTTVTPTPTPTGTQTP----TTTPITTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPT 3842 Query: 469 KLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVP 528 ++ P PT G + P T ++ TP G Sbjct: 3843 PTPTGTQTPTTTPITTTTTVTPTPTPT-------GTQTPTTTPITTTTTVTPTPTPTGTQ 3895 Query: 529 EKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGS 588 + + +T T P+ P +P + + + + + Sbjct: 3896 TPTT--TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3953 Query: 589 LPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPE 648 + P P G + + V P T TT + + P P T Sbjct: 3954 VTPTPTPTGTQTPTT--TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 4011 Query: 649 PAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAE 708 P P T TP G TP TT + T P T TT P TT+ + Sbjct: 4012 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP 4071 Query: 709 KDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCL 768 + P G + P + ++T + +P+ T ++ P +P G + P Sbjct: 4072 TPT-PTG-TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP-- 4127 Query: 769 YKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQ-PTDELLRHP 827 ++ V PT G P P P Q PT P Sbjct: 4128 ------TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT----P 4177 Query: 828 VTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLP-GSLRDHSHQAEASSDSIFHSQ 886 +T +P G G S+ P L + E+S+ S Sbjct: 4178 ITTTTTVTPTP----------TPTGTQTGPPTHTSTAPIAELTTSNPPPESSTPQTSRST 4227 Query: 887 GTP--NSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPV 944 +P S T++ LP E S P G G LS + T P P Sbjct: 4228 SSPLTESTTLLSTLPPAIEMTSTAPPSTPTAPTTTSG----GHTLSPPPSTTTSPPGTPT 4283 Query: 945 AWERVAPSNLPQGHPLPKSFSSPPSPS 971 S+ P + + +S +P+ Sbjct: 4284 RGTTTGSSSAPTPSTVQTTTTSAWTPT 4310 Score = 71.6 bits (174), Expect = 4e-12 Identities = 131/718 (18%), Positives = 212/718 (29%), Gaps = 48/718 (6%) Query: 60 TVSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNL 119 TV+ + T T P P+ T + PTP+ +T T+++ Sbjct: 2090 TVTPTPTPTGTQTPTTTPITTTTTVTP-------TPTPTGTQTPTTTPITTTTTVTPTPT 2142 Query: 120 RLYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSP-----PSTAPPPP 174 + P + P P G I+ +P P+P P+T P Sbjct: 2143 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2202 Query: 175 PLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAP 234 + P P P+ P + P T ++ PTP P + P P Sbjct: 2203 TTTVTPTPTPTGTQTPT------TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2256 Query: 235 APPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALG---PN 291 P +P T P T G Q T + P + G P Sbjct: 2257 TPTGTQTPTTT-----PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2311 Query: 292 PEPHLTFPRSFKVPPPTPVRT-SSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPAS 350 P T P PT +T ++ P+ + P+ P+ + + P Sbjct: 2312 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2371 Query: 351 QVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPL 410 + P P T +P +Q+ T P P P P P+ Sbjct: 2372 TPTGTQTP-TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 2430 Query: 411 --PPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQME 468 P P P T TP +++ + P P P + T ++ P+ Sbjct: 2431 TTTTTVTPTPTPTGTQTP----TTTPITTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPT 2485 Query: 469 KLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVP 528 ++ P PT G + P T ++ TP G Sbjct: 2486 PTPTGTQTPTTTPITTTTTVTPTPTPT-------GTQTPTTTPITTTTTVTPTPTPTGTQ 2538 Query: 529 EKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGS 588 + + +T T P+ P +P + + + + + Sbjct: 2539 TPTT--TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 2596 Query: 589 LPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPE 648 + P P G + + V P T TT + + P P T Sbjct: 2597 VTPTPTPTGTQ--TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 2654 Query: 649 PAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAE 708 P P T TP G TP TT + T P T TT P TT+ + Sbjct: 2655 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP 2714 Query: 709 KDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVP 766 + P G + P + ++T + +P+ T ++ P +P G + P Sbjct: 2715 TPT-PTG-TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 2770 Score = 71.6 bits (174), Expect = 4e-12 Identities = 131/718 (18%), Positives = 212/718 (29%), Gaps = 48/718 (6%) Query: 60 TVSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNL 119 TV+ + T T P P+ T + PTP+ +T T+++ Sbjct: 2550 TVTPTPTPTGTQTPTTTPITTTTTVTP-------TPTPTGTQTPTTTPITTTTTVTPTPT 2602 Query: 120 RLYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSP-----PSTAPPPP 174 + P + P P G I+ +P P+P P+T P Sbjct: 2603 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2662 Query: 175 PLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAP 234 + P P P+ P + P T ++ PTP P + P P Sbjct: 2663 TTTVTPTPTPTGTQTPT------TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2716 Query: 235 APPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALG---PN 291 P +P T P T G Q T + P + G P Sbjct: 2717 TPTGTQTPTTT-----PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2771 Query: 292 PEPHLTFPRSFKVPPPTPVRT-SSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPAS 350 P T P PT +T ++ P+ + P+ P+ + + P Sbjct: 2772 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2831 Query: 351 QVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPL 410 + P P T +P +Q+ T P P P P P+ Sbjct: 2832 TPTGTQTP-TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 2890 Query: 411 --PPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQME 468 P P P T TP +++ + P P P + T ++ P+ Sbjct: 2891 TTTTTVTPTPTPTGTQTP----TTTPITTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPT 2945 Query: 469 KLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVP 528 ++ P PT G + P T ++ TP G Sbjct: 2946 PTPTGTQTPTTTPITTTTTVTPTPTPT-------GTQTPTTTPITTTTTVTPTPTPTGTQ 2998 Query: 529 EKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGS 588 + + +T T P+ P +P + + + + + Sbjct: 2999 TPTT--TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3056 Query: 589 LPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPE 648 + P P G + + V P T TT + + P P T Sbjct: 3057 VTPTPTPTGTQ--TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 3114 Query: 649 PAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAE 708 P P T TP G TP TT + T P T TT P TT+ + Sbjct: 3115 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP 3174 Query: 709 KDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVP 766 + P G + P + ++T + +P+ T ++ P +P G + P Sbjct: 3175 TPT-PTG-TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 3230 Score = 71.6 bits (174), Expect = 4e-12 Identities = 131/718 (18%), Positives = 212/718 (29%), Gaps = 48/718 (6%) Query: 60 TVSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNL 119 TV+ + T T P P+ T + PTP+ +T T+++ Sbjct: 3010 TVTPTPTPTGTQTPTTTPITTTTTVTP-------TPTPTGTQTPTTTPITTTTTVTPTPT 3062 Query: 120 RLYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSP-----PSTAPPPP 174 + P + P P G I+ +P P+P P+T P Sbjct: 3063 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3122 Query: 175 PLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAP 234 + P P P+ P + P T ++ PTP P + P P Sbjct: 3123 TTTVTPTPTPTGTQTPT------TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3176 Query: 235 APPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALG---PN 291 P +P T P T G Q T + P + G P Sbjct: 3177 TPTGTQTPTTT-----PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 3231 Query: 292 PEPHLTFPRSFKVPPPTPVRT-SSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPAS 350 P T P PT +T ++ P+ + P+ P+ + + P Sbjct: 3232 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 3291 Query: 351 QVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPL 410 + P P T +P +Q+ T P P P P P+ Sbjct: 3292 TPTGTQTP-TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 3350 Query: 411 --PPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQME 468 P P P T TP +++ + P P P + T ++ P+ Sbjct: 3351 TTTTTVTPTPTPTGTQTP----TTTPITTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPT 3405 Query: 469 KLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVP 528 ++ P PT G + P T ++ TP G Sbjct: 3406 PTPTGTQTPTTTPITTTTTVTPTPTPT-------GTQTPTTTPITTTTTVTPTPTPTGTQ 3458 Query: 529 EKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGS 588 + + +T T P+ P +P + + + + + Sbjct: 3459 TPTT--TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3516 Query: 589 LPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPE 648 + P P G + + V P T TT + + P P T Sbjct: 3517 VTPTPTPTGTQ--TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 3574 Query: 649 PAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAE 708 P P T TP G TP TT + T P T TT P TT+ + Sbjct: 3575 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP 3634 Query: 709 KDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVP 766 + P G + P + ++T + +P+ T ++ P +P G + P Sbjct: 3635 TPT-PTG-TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 3690 Score = 70.5 bits (171), Expect = 9e-12 Identities = 118/637 (18%), Positives = 188/637 (29%), Gaps = 41/637 (6%) Query: 141 PPPPGPAPGPPQDISEPPGGSPLPSP-----PSTAPPPPPLLLEPPPPPSMAPPPPPVLE 195 P P G I+ +P P+P P+T P + P P P+ P Sbjct: 1934 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT---- 1989 Query: 196 ALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGV 255 + P T ++ PTP P + P P P +P T P Sbjct: 1990 --TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT-----PITTT 2042 Query: 256 TKWKSDVALNGRQAEATRASPPRSPAEPKGSALG---PNPEPHLTFPRSFKVPPPTPVRT 312 T G Q T + P + G P P T P PT +T Sbjct: 2043 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 2102 Query: 313 -SSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAP 371 ++ P+ + P+ P+ + + P + P P T Sbjct: 2103 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP-TTTPITTTTTVT 2161 Query: 372 ASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPL--PPAAPPLPCAQKAAHPPAG 429 +P +Q+ T P P P P P+ P P P Sbjct: 2162 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP--- 2218 Query: 430 FTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLS 489 T TP +++ + P P P + T ++ P+ ++ Sbjct: 2219 -TTTPITTTTTVTPTPTPTGTQ-TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 2276 Query: 490 HRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLP 549 P PT G + P T ++ TP G + + +T T P Sbjct: 2277 PTPTPT-------GTQTPTTTPITTTTTVTPTPTPTGTQTPTT--TPITTTTTVTPTPTP 2327 Query: 550 SVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDK 609 + P +P + + + + ++ P P G + Sbjct: 2328 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ--TPTTTPIT 2385 Query: 610 LSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGP 669 + V P T TT + + P P T P P T TP G Sbjct: 2386 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 2445 Query: 670 ATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPS 729 TP TT + T P T TT P TT+ + + P G + P + ++T + Sbjct: 2446 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT-PTG-TQTPTTTPITTTT 2503 Query: 730 QARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVP 766 +P+ T ++ P +P G + P Sbjct: 2504 TVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 2540 Score = 63.5 bits (153), Expect = 1e-09 Identities = 56/215 (26%), Positives = 73/215 (33%), Gaps = 23/215 (10%) Query: 610 LSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGP 669 + K + PP +T P TS +PP TP PP T T P T P Sbjct: 1392 MDKCITTPSPPTTTPSPPPTST-------TTLPPTTTPS---PPTTT---TTTPPPTTTP 1438 Query: 670 ATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPS 729 + P+ T+ P P T P I++T T PTTT S P P P + + P Sbjct: 1439 SPPITTTTTP--PPTTTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPP 1496 Query: 730 QARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMP-- 787 +PS T P S+ PP T+P P S + P Sbjct: 1497 TT----TPSPPTTTPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTS 1552 Query: 788 --TLARGGAAGPGEPVEVKEPPGLPAKPPASAQPT 820 TL P PP PP + P+ Sbjct: 1553 TTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPS 1587 Score = 54.7 bits (130), Expect = 5e-07 Identities = 89/382 (23%), Positives = 121/382 (31%), Gaps = 80/382 (20%) Query: 60 TVSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNL 119 TV+ + T T P P+ T + PTP+ +T T+++ Sbjct: 4091 TVTPTPTPTGTQTPTTTPITTTTTVTP-------TPTPTGTQTPTTTPITTTTTVTPTPT 4143 Query: 120 RLYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLE 179 + P + P P G I+ +P P+P T PP Sbjct: 4144 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTGPPTHTST 4203 Query: 180 PPPPPSMAPPPPPVLEALSPPHTLSSPSIP-----TPPDFIPPAPPLAFLAPPPPPVPAP 234 P PPP S P T S S P T +PPA + APP P Sbjct: 4204 APIAELTTSNPPP---ESSTPQTSRSTSSPLTESTTLLSTLPPAIEMTSTAPPSTPT--- 4257 Query: 235 APPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAE--PKGSALGPNP 292 AP + HT L PP +T SPP +P GS+ P P Sbjct: 4258 APTTTSGGHT----LSPP-----------------PSTTTSPPGTPTRGTTTGSSSAPTP 4296 Query: 293 EPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHI------ 346 T S P PTP+ T SI + P P S I Sbjct: 4297 STVQTTTTSAWTPTPTPLSTPSII----------------RTTGLRPYPSSVLICCVLND 4340 Query: 347 ---RPASQVYPDRAPEP--------DCPGEL-KATAPASPRLGQSQSQADERAGTPPPAP 394 P +VY + C E + P++P + S++ TP P+ Sbjct: 4341 TYYAPGEEVYNGTYGDTCYFVNCSLSCTLEFYNWSCPSTPSPTPTPSKS-----TPTPSK 4395 Query: 395 PLPPPAPPLPPPAPPLPPAAPP 416 P P+ P P PP P P Sbjct: 4396 PSSTPSKPTPGTKPPECPDFDP 4417 Score = 33.5 bits (75), Expect = 1.2 Identities = 17/49 (34%), Positives = 21/49 (42%), Gaps = 7/49 (14%) Query: 141 PPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPP 189 P P P P P + +P PS PS+ P P +PP P PP Sbjct: 4377 PSTPSPTPTPSK-------STPTPSKPSSTPSKPTPGTKPPECPDFDPP 4418 >gi|160707881 formin 2 [Homo sapiens] Length = 1722 Score = 137 bits (346), Expect = 5e-32 Identities = 131/376 (34%), Positives = 151/376 (40%), Gaps = 76/376 (20%) Query: 130 PGQYGQDLLIPPPPPGPAPG--PPQDISEPPGGSPLPSPP---STAPPPPPL--LLEPPP 182 P G ++L PPPPP P G PP + PG LP PP + PPPPPL PPP Sbjct: 900 PPLQGTEMLPPPPPPLPGAGIPPPPPL---PGAGILPLPPLPGAGIPPPPPLPGAAIPPP 956 Query: 183 PP---SMAPPPPPVLEA-LSPPHTLSSPSIPTPPDF----IPPAPPLAFLA-PPPPPVP- 232 PP + P PPP+ A + PP L IP PP IPP PPL PPPPP+P Sbjct: 957 PPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1016 Query: 233 APAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNP 292 A PP P P G + PP A P P P P P Sbjct: 1017 AGIPPPPPLP---GAGIPPP----------------PPLPGAGIPPPPPLPGAGIPPPPP 1057 Query: 293 EPHLTFP-----RSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLP---LPPSF 344 P P +PPP P+ + IP P GA P LP +PP Sbjct: 1058 LPGAGIPPPPPLPGAGIPPPPPLPGAGIP------PPPPLPGAGIPPPPPLPGVGIPPPP 1111 Query: 345 HIRPASQVYPDR-------APEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLP 397 + P + + P P P PG P PR+G AG PPP PPLP Sbjct: 1112 PL-PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPP-PPLP 1169 Query: 398 ----PPAPPLP----PPAPPLP----PAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKP 445 PP PPLP PP PPLP P PPLP A PP P + +P L P Sbjct: 1170 GAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPPPG 1229 Query: 446 N--PPSPENTASSAPV 459 PP P S P+ Sbjct: 1230 TGIPPPPLLPVSGPPL 1245 Score = 112 bits (279), Expect = 3e-24 Identities = 116/338 (34%), Positives = 125/338 (36%), Gaps = 60/338 (17%) Query: 139 IPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAP----PPPPLLLEPPPPP----SMAPPP 190 IP PPP P + S PG +P PP P P P P PPP M PPP Sbjct: 855 IPSPPPLPCT---ESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPP 911 Query: 191 PPVLEALSPPHTLSSPSIPTPPDFIPPAPPL--AFLAPPPPPVPAPAPPAPASPHTVGTR 248 PP L P P P P I P PPL A + PPPPP+P A P P G Sbjct: 912 PPPLPGAGIP-----PPPPLPGAGILPLPPLPGAGI-PPPPPLPGAAIPPPPPLPGAGIP 965 Query: 249 LFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPT 308 L PP L G A P P P P P P +PPP Sbjct: 966 LPPPLPGAGIPPPPPLPG-------AGIPPPPPLPGAGIPPPPPLP------GAGIPPPP 1012 Query: 309 PVRTSSIPVQEAQEAPRKEEGATKKAPSRLP---LPPSFHIRPASQVYPDRAPEPDCPGE 365 P+ + IP P GA P LP +PP P P P PG Sbjct: 1013 PLPGAGIP------PPPPLPGAGIPPPPPLPGAGIPP-----PPPLPGAGIPPPPPLPGA 1061 Query: 366 LKATAPASPRLGQSQSQADERAGTPPPAPPLP----PPAPPLP----PPAPPLP----PA 413 P P G AG PPP PPLP PP PPLP PP PPLP P Sbjct: 1062 GIPPPPPLPGAGIPPPPPLPGAGIPPP-PPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPP 1120 Query: 414 APPLPCAQKAAHPP-AGFTKTPKSSSPALKPKPNPPSP 450 PPLP A PP G P P + P PP P Sbjct: 1121 PPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLP 1158 Score = 107 bits (267), Expect = 7e-23 Identities = 106/310 (34%), Positives = 118/310 (38%), Gaps = 52/310 (16%) Query: 139 IPPPPPGPAPGPPQDISEPPGGSPLPSPPSTA--PPPPPLLLE--PPPPP---SMAPPPP 191 IPPPPP P G P P G P P P A PPPPPL PPPPP + PPPP Sbjct: 986 IPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP 1045 Query: 192 PVLEA-LSPPHTLSSPSIPTPPDF----IPPAPPLAFLA-PPPPPVPAPAPPAPASPHTV 245 P+ A + PP L IP PP IPP PPL PPPPP+P P P V Sbjct: 1046 PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGV 1105 Query: 246 GTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVP 305 G PP L G A P P P P P P + +P Sbjct: 1106 GIPPPPPLPGAGIPPPPPLPG-------AGIPPPPPLPGAGIPPPPPLPRVG------IP 1152 Query: 306 PPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLP---LPPSFHIRPASQVYPDRAPEPDC 362 PP P+ + IP P GA P LP +PP P P P Sbjct: 1153 PPPPLPGAGIP------PPPPLPGAGIPPPPPLPGVGIPP-----PPPLPGVGIPPPPPL 1201 Query: 363 PGELKATAPASPRLGQSQSQADERAGTPPPAPPLP---PPAPPLPPPAPPLPP--AAPPL 417 PG P P +G + A PP PP PP P LP PPL P + L Sbjct: 1202 PGAGIPPPPPLPGMGIPPAPA-------PPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTL 1254 Query: 418 PCAQKAAHPP 427 P Q P Sbjct: 1255 PTPQVCGFLP 1264 Score = 105 bits (263), Expect = 2e-22 Identities = 170/640 (26%), Positives = 207/640 (32%), Gaps = 176/640 (27%) Query: 140 PPPPPGPAPGP-------------PQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSM 186 PP PPG GP P+ IS S PPPP LL Sbjct: 767 PPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQPPPPPSLLWSAGQGQPG 826 Query: 187 APPPPPVLEALSPPHTLS-------SPSIPTPP-----DFIPPAPPLAFLAPPPPPVPA- 233 + PP + H S S +IP+PP + P L + PPPPP+P Sbjct: 827 SQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGM 886 Query: 234 -----PAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSAL 288 P+ P P GT + PP L G A P P P L Sbjct: 887 TVPTLPSTAIPQPPPLQGTEMLPP-------PPPPLPG-------AGIPPPPPLPGAGIL 932 Query: 289 GPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRP 348 P P +PPP P+ ++IP P GA +PLPP P Sbjct: 933 PLPPLP------GAGIPPPPPLPGAAIP------PPPPLPGA------GIPLPPPL---P 971 Query: 349 ASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLP----PPAPPLP 404 + + P P PG P P G AG PPP PPLP PP PPLP Sbjct: 972 GAGI----PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP-PPLPGAGIPPPPPLP 1026 Query: 405 ----PPAPPLP----PAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPN---PPSPENT 453 PP PPLP P PPLP A PP P + P P P PP P Sbjct: 1027 GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP-----LPGAGIPPPPPLPGAGIPPPPPLP 1081 Query: 454 ASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKE 513 + P P + PG + P P LP Sbjct: 1082 GAGIP----PPPPL------------------------PGAGIPPP-------PPLPG-- 1104 Query: 514 TLLSLPAKDTPPGV---PEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNEL 570 + +P PG P L G+ + P +P P P + ++ Sbjct: 1105 --VGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP---------PPPPLPRVGIPP 1153 Query: 571 EARLSSAAEKEAKPSIGS-LPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTT 629 L A P G+ +PP P L G +PP LP Sbjct: 1154 PPPLPGAGIPPPPPLPGAGIPPPPPLPG------------------VGIPPPPP--LPGV 1193 Query: 630 SLQPKAML-GPAI-PPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATS 687 + P L G I PP P IPP P PP T P PL SGP PL Sbjct: 1194 GIPPPPPLPGAGIPPPPPLPGMGIPPAPA--PPLPPPGTGIPPPPLLPVSGP--PLLPQV 1249 Query: 688 GPAIASTATT-------LPTTTSQLMAEKDSGPAGQPEKP 720 G + T LP+ L +D G QP +P Sbjct: 1250 GSSTLPTPQVCGFLPPPLPSGLFGLGMNQDKGSRKQPIEP 1289 Score = 37.4 bits (85), Expect = 0.086 Identities = 51/206 (24%), Positives = 68/206 (33%), Gaps = 34/206 (16%) Query: 160 GSPLPSPPSTAPPPPP--------LLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTP 211 G+ P+ P TA P P LL P AP P +ALS L P Sbjct: 228 GAEEPAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAAEP 287 Query: 212 PDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGR---- 267 + P P P +PA P A SP + FP G + + + G Sbjct: 288 REPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFP-FPEAGPGEEAAGAPVRGAGDTD 346 Query: 268 ---QAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQ--E 322 + +A +P SP E +G + P R P +EAQ + Sbjct: 347 EEGEEDAFEDAPRGSPGEEWAPEVGED----------------APQRLGEEPEEEAQGPD 390 Query: 323 APRKEEGATKKAPSRLPLPPSFHIRP 348 AP APS+ P I P Sbjct: 391 APAAASLPGSPAPSQRCFKPYPLITP 416 Score = 37.4 bits (85), Expect = 0.086 Identities = 35/116 (30%), Positives = 40/116 (34%), Gaps = 23/116 (19%) Query: 938 PEPQAPVAWERVAP----SNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFS 993 P P P A P + +P PLP + PP P IPPPP Sbjct: 1043 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG----------IPPPPPLP 1092 Query: 994 NDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAG 1049 PP P L +G PP LP AG PP L + P GAG Sbjct: 1093 GAGIPPPPPLPGVGIPPPPP---------LPGAGIPPPPPLPGAGIPPPPPLPGAG 1139 Score = 36.6 bits (83), Expect = 0.15 Identities = 35/117 (29%), Positives = 40/117 (34%), Gaps = 14/117 (11%) Query: 938 PEPQAPVAWERVAP----SNLPQGHPLPKSFSSPPSP-SNKREEEEEEFNFEVIPPPPEF 992 P P P A + P + +P PLP + PP P IPPPP Sbjct: 955 PPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1014 Query: 993 SNDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAG 1049 PP P L G PP LP AG PP L + P GAG Sbjct: 1015 PGAGIPPPPPLPGAGIPPPPP---------LPGAGIPPPPPLPGAGIPPPPPLPGAG 1062 Score = 36.6 bits (83), Expect = 0.15 Identities = 35/116 (30%), Positives = 39/116 (33%), Gaps = 23/116 (19%) Query: 938 PEPQAPVAWERVAP----SNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFS 993 P P P A P + +P PLP + PP P IPPPP Sbjct: 999 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG----------IPPPPPLP 1048 Query: 994 NDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAG 1049 PP P L G PP LP AG PP L + P GAG Sbjct: 1049 GAGIPPPPPLPGAGIPPPPP---------LPGAGIPPPPPLPGAGIPPPPPLPGAG 1095 Score = 35.4 bits (80), Expect = 0.33 Identities = 29/96 (30%), Positives = 33/96 (34%), Gaps = 19/96 (19%) Query: 954 LPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPP 1013 +P PLP + PP P IPPPP PP P L +G PP Sbjct: 1107 IPPPPPLPGAGIPPPPPLPGAG----------IPPPPPLPGAGIPPPPPLPRVGIPPPPP 1156 Query: 1014 RNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAG 1049 LP AG PP L + P G G Sbjct: 1157 ---------LPGAGIPPPPPLPGAGIPPPPPLPGVG 1183 Score = 35.0 bits (79), Expect = 0.43 Identities = 60/235 (25%), Positives = 84/235 (35%), Gaps = 29/235 (12%) Query: 370 APASPRLGQSQSQAD---ERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHP 426 AP SP Q+ S E P P PP LP AP LP AQ AA Sbjct: 263 APGSPDTEQALSALSDLPESLAAEPREPQQPPSPGGLP------VSEAPSLPAAQPAA-- 314 Query: 427 PAGFTKTPKSSSPALKPKPNPPS-PENTASSAPVDWRDPSQMEKLRNELAAYLCGSRRED 485 SP+ P P + P A+ APV + E + GS E+ Sbjct: 315 ---------KDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGEEDAFEDAPRGSPGEE 365 Query: 486 --RFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAA 543 + + + +E +GP P +L PA P + + T Sbjct: 366 WAPEVGEDAPQRLGEEPEEEAQGPDAPAAASLPGSPAPSQRCFKPYPLITPCYIKTT--- 422 Query: 544 PSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGG 598 + L S ++ P SP S R I+ E LS + + A S+ + K R +GG Sbjct: 423 -TRQLSSPNHSPSQSPNQSPR-IKRRPEPSLSRGS-RTALASVAAPAKKHRADGG 474 Score = 35.0 bits (79), Expect = 0.43 Identities = 35/117 (29%), Positives = 39/117 (33%), Gaps = 14/117 (11%) Query: 938 PEPQAPVAWERVAP----SNLPQGHPLPKSFSSPPSP-SNKREEEEEEFNFEVIPPPPEF 992 P P P A P + +P PLP + PP P IPPPP Sbjct: 922 PPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPL 981 Query: 993 SNDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAG 1049 PP P L G PP LP AG PP L + P GAG Sbjct: 982 PGAGIPPPPPLPGAGIPPPPP---------LPGAGIPPPPPLPGAGIPPPPPLPGAG 1029 Score = 34.7 bits (78), Expect = 0.56 Identities = 47/179 (26%), Positives = 55/179 (30%), Gaps = 45/179 (25%) Query: 938 PEPQAPVAWERVAP----SNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFS 993 P P P A P + +P PLP+ PP P IPPPP Sbjct: 1120 PPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAG----------IPPPPPLP 1169 Query: 994 NDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGLER 1053 PP P L +G PP LP G PP L + P G G Sbjct: 1170 GAGIPPPPPLPGVGIPPPPP---------LPGVGIPPPPPLPGAGIPPPPPLPGMG---- 1216 Query: 1054 FSGGGRSLIKKRLYVGEPHRGPGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPP 1112 P P LP GTG P P G P + +V S+ P Sbjct: 1217 ---------------IPPAPAPPLPPPGTG---IPPPPLLPVSGPPLLPQVGSSTLPTP 1257 Score = 33.9 bits (76), Expect = 0.95 Identities = 48/177 (27%), Positives = 59/177 (33%), Gaps = 36/177 (20%) Query: 277 PRSP-AEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAP 335 P SP E SAL PE PR P P +PV EA P + A K +P Sbjct: 264 PGSPDTEQALSALSDLPESLAAEPRE----PQQPPSPGGLPVSEAPSLPAAQPAA-KDSP 318 Query: 336 SRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPA-----SPRLGQSQSQADERAGTP 390 S P +P+ P GE A AP + G+ + D G+P Sbjct: 319 SSTAFP-----------FPEAGP-----GEEAAGAPVRGAGDTDEEGEEDAFEDAPRGSP 362 Query: 391 PP--APPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKP 445 AP + AP P P P A A +P S KP P Sbjct: 363 GEEWAPEVGEDAPQRLGEEPEEEAQGPDAPAA-------ASLPGSPAPSQRCFKPYP 412 Score = 32.7 bits (73), Expect = 2.1 Identities = 33/110 (30%), Positives = 36/110 (32%), Gaps = 13/110 (11%) Query: 953 NLPQGHPLPKSFSS---------PPSPSNKREEEEEEFNFEVIPPPPEFSNDP--EPPAP 1001 N+P PLP + SS PP P IP PP PP P Sbjct: 854 NIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPP 913 Query: 1002 ALQYLGRQSSPPRNNYS--DLRQLPNAGPGAPPALGFSRFPAGARYAGAG 1049 L G PP L LP AG PP L + P GAG Sbjct: 914 PLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAG 963 >gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo sapiens] Length = 5537 Score = 133 bits (334), Expect = 1e-30 Identities = 251/1025 (24%), Positives = 344/1025 (33%), Gaps = 218/1025 (21%) Query: 138 LIPPPPPGPAPGPPQD--ISEPPGGSPLPSPPSTAPPPP---------PLL---LEPPPP 183 L+PPP P PP++ S PP S L PP P P PL L PPP Sbjct: 440 LLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPE 499 Query: 184 PSMAPPPP------PVLEA-LSPPH-TLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPA 235 S PPP P+ E+ LSPP + SP++ TP + P P + L+PP P Sbjct: 500 ESPLSPPPESSPFSPLEESPLSPPEESPPSPALETP---LSPPPEASPLSPPFEESPLSP 556 Query: 236 PP--APASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPE 293 PP P SP +RL PP E + SPP P+ S + P PE Sbjct: 557 PPEELPTSPPPEASRLSPP----------------PEESPMSPP-----PEESPMSPPPE 595 Query: 294 PHLTFPRSFKVP--PPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPAS- 350 FP + P PP S P + ++ +P E+ P P+ P + S Sbjct: 596 ASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSP 655 Query: 351 -QVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAG--TPPPAPPLPPPAPPLPPPA 407 V +P P+ +P SP +S + A +PPP P P P + Sbjct: 656 LPVVSRLSPPPE-------ESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPAS 708 Query: 408 PPLPPAAPPLPCAQKAAHP-PAGFTKTPKSSSPALKPKPNPP--SPENTASSAPVDWRDP 464 PP + LP + P P P+S P L P+P P SP +P Sbjct: 709 PPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEP 768 Query: 465 SQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTP 524 + LC E GP ++PQ +E P+ E Sbjct: 769 HLSPQPEEPC---LCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHL---------- 815 Query: 525 PGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKP 584 VPE+ E+ +P P + SP P + ELE KP Sbjct: 816 SPVPEEPCLSPQPEESHLSPQSEEPCL------SPRPEESHLSPELE-----------KP 858 Query: 585 SIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPK 644 + P KP E G+ P + LP L P + L P + Sbjct: 859 PLSPRPEKPPEEPGQC------------PAPEELP-----LFPPPG---EPSLSPLLGEP 898 Query: 645 ATPEPAIPPKATLWPATPPKATLGPA--TPLKATSGPTTPLKATSGPAIASTATTLPTTT 702 A EP PP + L P + L P+ L P PL P I + A + Sbjct: 899 ALSEPGEPPLSPL----PEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSPL 954 Query: 703 SQLMAEKDSGPAGQPEKP-ASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKT-SP 760 +L + PE P A+ + TP E + ++ +P PP SP Sbjct: 955 GELEYPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPM------ILPPSPGSP 1008 Query: 761 GGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQP- 819 G P L +P Q S L + P PP LP P+ P Sbjct: 1009 VGPASPILMEPLPPQCS----------PLLQHSLVPQNSPPSQCSPPALPLSVPSPLSPI 1058 Query: 820 ------TDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSH 873 +DE H + E V AL +A S LP + D S Sbjct: 1059 GKVVGVSDEAELHEMETEKVSEPECPALEPSA---------------TSPLPSPMGDLSC 1103 Query: 874 QAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRH 933 A + + ++ G + + D+P + P + L + +G+ + Sbjct: 1104 PAPSPAPALDDFSGLGEDTAPLDGI------DAPGSQPEPGQTPGSLASELKGSPV---- 1153 Query: 934 NWTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPP--- 990 PE APV V +P K + SP EE+EE V P PP Sbjct: 1154 -LLDPEELAPVTPMEV--------YPECKQTAGQGSPC----EEQEEPRAPVAPTPPTLI 1200 Query: 991 ------EFSN--------------------DPEPPAPALQYLGRQSS-PPRNNYSDLRQL 1023 E SN DPE LG + P + LR Sbjct: 1201 KSDIVNEISNLSQGDASASFPGSEPLLGSPDPEGGGSLSMELGVSTDVSPARDEGSLRLC 1260 Query: 1024 PNAGPGAPPALGFSRFPA--GARYAGAGGLERFSGGGRSLIKKRLYVGEP--HRGPGLPH 1079 ++ P +L A G + G G R S RS IK+ P R G H Sbjct: 1261 TDSLPETDDSLLCDAGTAISGGKAEGEKGRRR-SSPARSRIKQGRSSSFPGRRRPRGGAH 1319 Query: 1080 GGTGR 1084 GG GR Sbjct: 1320 GGRGR 1324 Score = 83.2 bits (204), Expect = 1e-15 Identities = 237/982 (24%), Positives = 327/982 (33%), Gaps = 184/982 (18%) Query: 101 DDFADKEVTGTSSLVNGNLRLYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEP--- 157 D+ A + + + VGD+ L + PP A G P + P Sbjct: 2066 DNRAAHRINKVQKQAESQINKQTKVGDIARKTDRPALHLRIPPQPGALGSPPPAAAPTIF 2125 Query: 158 ------PGG----------SPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPH 201 P G P S P P L PP P+ P P L+P + Sbjct: 2126 IGSPTTPAGLSTSADGFLKPPAGSVPGPDSPGELFLKLPPQVPAQVPSQDPF--GLAPAY 2183 Query: 202 TLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKS- 260 L P PT P PP P PP + A + P P T PPG S Sbjct: 2184 PL-EPRFPTAPPTYPPYPSPTGAPAQPPMLGASSRPGAGQPGEFHTT--PPGTPRHQPST 2240 Query: 261 -DVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQE 319 D L R + P SP G A EP L+ PPP ++ Sbjct: 2241 PDPFLKPRCPSLDNLAVPESPGVGGGKA----SEPLLS-------PPPFG------ESRK 2283 Query: 320 AQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQS 379 A E ++E GA+ +PS P F P+S + E P K AP +PR Q Sbjct: 2284 ALEVKKEELGAS--SPSYGPPNLGFVDSPSSGTHLG-GLELKTPDVFK--APLTPRASQV 2338 Query: 380 QSQADE---RAGTPPPA---PPLPPPAPPL--------PPPAPPLPPAAPPLPCAQKAAH 425 + Q+ R PPPA P PP P + P PPL P P P A Sbjct: 2339 EPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQPPPPESCCAL 2398 Query: 426 PPAGFTKTPKSSSPALKPKPNPPSPENTASS-APVDWRDPSQMEKLRNELAAYLCGSRRE 484 PP P S PA SP++ +SS +P+ R S A C S Sbjct: 2399 PPRSLPSDPFSRVPA--------SPQSQSSSQSPLTPRPLS---------AEAFCPSPVT 2441 Query: 485 DRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEK-------SLG-GSS 536 RF S P P P S+ + P P L P + PP V K SLG G Sbjct: 2442 PRFQS--PDPYSRPPSRPQSRDPFAP-----LHKPPRPQPPEVAFKAGSLAHTSLGAGGF 2494 Query: 537 LTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSA-----AEKEAKPSIGSLPP 591 A P+ L + +P P VR S + +PS+ P Sbjct: 2495 PAALPAGPAGELHA--KVPSGQPPNFVRSPGTGAFVGTPSPMRFTFPQAVGEPSLKPPVP 2552 Query: 592 KPRLEGGR-ICENGADDDKLSKP-------VAKNLPPQSTTLLPTTSLQPKAM-LGPAIP 642 +P L I + L KP N P + L P++ ++ L P P Sbjct: 2553 QPGLPPPHGINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPSSGSTGESYGLSPLRP 2612 Query: 643 PKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTT 702 P P PA P +L P + G + SG T+P++ P T T Sbjct: 2613 PSVLPPPA--PDGSL-----PYLSHGAS----QRSGITSPVEKREDP---GTGMGSSLAT 2658 Query: 703 SQLMAEKDSGPAG--------QPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAF 754 ++L +D G +G Q ++ +E+ Q + E T A + A Sbjct: 2659 AELPGTQDPGMSGLSQTELEKQRQRQRLRELLIRQQIQRNTLRQEK---ETAAAAAGAVG 2715 Query: 755 PP------KTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPG---EPVEVKE 805 PP +SP ++ P S V + P+ G GPG + Sbjct: 2716 PPGSWGAEPSSPAFEQLSRGQTPFAGTQDKSSLVG-LPPSKLSGPILGPGSFPSDDRLSR 2774 Query: 806 PPGLPAKPPASAQPTDELLRHPVTG-EVVERGSPMALLLAARQRAQKGRSVGAALGRSSL 864 PP PPA+ D R V G + + +P L +Q+ Q+ Sbjct: 2775 PP-----PPATPSSMDVNSRQLVGGSQAFYQRAPYPGSLPLQQQQQQ------------- 2816 Query: 865 PGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPL---TTEIPNKWGPRLG 921 L A+S S P+ T P+L ++A SPL +T +P P G Sbjct: 2817 ---LWQQQQATAATSMRFAMSARFPS--TPGPELGRQA-LGSPLAGISTRLPGPGEPVPG 2870 Query: 922 RDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEF 981 + RHN K + P P+ +P+ + P E Sbjct: 2871 PAGPAQFIELRHNVQKGLGPGGTPFPGQGPPQRPRFYPVSE------DPHRLAPEGLRGL 2924 Query: 982 NFEVIPPPPEFSNDPEPPAPAL 1003 +PP PPAP L Sbjct: 2925 AVSGLPP----QKPSAPPAPEL 2942 Score = 66.2 bits (160), Expect = 2e-10 Identities = 123/451 (27%), Positives = 168/451 (37%), Gaps = 102/451 (22%) Query: 130 PGQYG--QDLLIPPPPPGPAPGP---PQDISEP--PGGSPLP-----SP---PSTAP--- 171 PGQ ++L + PPP P+ P +SEP P SPLP SP PS +P Sbjct: 871 PGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLM 930 Query: 172 PPPPLLLEPPPPPSMAPPPPPVLEAL-------------SPPHTLSSPSIPTPPDFIPPA 218 PP PL PP P + PP L L P L++P + TP I P Sbjct: 931 PPDPL--PPPLSPIITAAAPPALSPLGELEYPFGAKGDSDPESPLAAPILETP---ISP- 984 Query: 219 PPLAFLAPPPPPVPAPAPPAPASPHTVGTRL----FPPGGVTKWKSDVALNGRQAEATRA 274 PP A P P P PP+P SP + + PP + +L + + ++ Sbjct: 985 PPEANCTDPEPVPPMILPPSPGSPVGPASPILMEPLPPQCSPLLQH--SLVPQNSPPSQC 1042 Query: 275 SPPR------SPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEE 328 SPP SP P G +G + E L + KV P E P E Sbjct: 1043 SPPALPLSVPSPLSPIGKVVGVSDEAELHEMETEKVSEP--------------ECPALEP 1088 Query: 329 GATKKAPSRL-----PLP-PSFHIRPASQVYPDRAPEP--DCPGELKATAPASPRLGQSQ 380 AT PS + P P P+ + S + D AP D PG + P GQ+ Sbjct: 1089 SATSPLPSPMGDLSCPAPSPAPALDDFSGLGEDTAPLDGIDAPG-------SQPEPGQTP 1141 Query: 381 -SQADERAGTPPPAPP--LPPPAP---------------PLPPPAPPLPPAAPPLPCAQK 422 S A E G+P P L P P P P P AP P K Sbjct: 1142 GSLASELKGSPVLLDPEELAPVTPMEVYPECKQTAGQGSPCEEQEEPRAPVAPTPPTLIK 1201 Query: 423 A--AHPPAGFTKTPKSSS-PALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLC 479 + + + ++ S+S P +P P PE S ++ + + R+E + LC Sbjct: 1202 SDIVNEISNLSQGDASASFPGSEPLLGSPDPEG-GGSLSMELGVSTDVSPARDEGSLRLC 1260 Query: 480 GSR--REDRFLSHRPGPTVAPQSKEGKKGPR 508 D L G ++ EG+KG R Sbjct: 1261 TDSLPETDDSLLCDAGTAISGGKAEGEKGRR 1291 Score = 63.2 bits (152), Expect = 1e-09 Identities = 118/499 (23%), Positives = 167/499 (33%), Gaps = 104/499 (20%) Query: 64 SGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLRLYS 123 S L+ VR L QE L + P++ +F+ G+ VNG +L Sbjct: 4534 SSRKKLRKEDGVRASEALLKQLKQELSLLPLTEPAITANFSLFAPFGSGCPVNGQSQLRG 4593 Query: 124 SVGD----LRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLE 179 + G P Y Q L ++S PP +PPS+ PP PP ++ Sbjct: 4594 AFGSGALPTGPDYYSQLLT------------KNNLSNPP------TPPSSLPPTPPPSVQ 4635 Query: 180 PP------PPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIP--PAPP------LAFLA 225 P + P A L S D + P PP + + Sbjct: 4636 QKMVNGVTPSEELGEHPKDAASARDSERALRDTSEVKSLDLLAALPTPPHNQTEDVRMES 4695 Query: 226 PPPPPVPAPAPPAPASPHTVGTRL--FPPGGVTKWKS-DVALNGRQAEATRASPPRSPAE 282 P PA + +G FP G +W+ D AL+ RAS P P Sbjct: 4696 DEDSDSPDSIVPASSPESILGEEAPRFPHLGSGRWEQEDRALSPVIPLIPRASIPVFPDT 4755 Query: 283 PKGSALG---PNPEPHLTFPR-------------------------------SFKVP--- 305 ALG P P T+ + S K+P Sbjct: 4756 KPYGALGLEVPGKLPVTTWEKGKGSEVSVMLTVSAAAAKNLNGVMVAVAELLSMKIPNSY 4815 Query: 306 ----PPTPVRTSSIPVQEAQEAPR-KEEGATKKAPSRLP--------LPPSFHIRPASQV 352 P +P R + P + E P KE+G K+P P + P + ++ + Sbjct: 4816 EVLFPESPARAGTEPKKGEAEGPGGKEKGLEGKSPDTGPDWLKQFDAVLPGYTLKSQLDI 4875 Query: 353 YP---DRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPP 409 +P P+ P + T S L Q A PPP P PPP+P P PA P Sbjct: 4876 LSLLKQESPAPEPPTQHSYTYNVS-NLDVRQLSA------PPPEEPSPPPSPLAPSPASP 4928 Query: 410 LPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAP---VDWRDPSQ 466 LP + A PP SS + +PKP PE S P W+ + Sbjct: 4929 PTEPLVELP-TEPLAEPPVPSPLPLASSPESARPKPRARPPEEGEDSRPPRLKKWKG-VR 4986 Query: 467 MEKLRNELAAYLCGSRRED 485 ++LR L R+ED Sbjct: 4987 WKRLRLLLTIQKGSGRQED 5005 Score = 58.9 bits (141), Expect = 3e-08 Identities = 167/769 (21%), Positives = 247/769 (32%), Gaps = 98/769 (12%) Query: 144 PGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTL 203 PGP GP Q++ G P P P P PP L P + P PPP Sbjct: 4267 PGPQTGPLQEL----GAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPP----------- 4311 Query: 204 SSPSIPTPPDFIP-PAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDV 262 SSP P P +P P+ L A PP P P P P T PPG V+ + + Sbjct: 4312 SSPQEPKRPSQLPSPSSQLPTEAQLPP--THPGTPKPQGP----TLEPPPGRVSPAAAQL 4365 Query: 263 ALNGRQAEATRASPPRSPAE---PKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQE 319 A PP + AE P+ S+L P HL VP + + P +E Sbjct: 4366 ADTLFSKGLGPWDPPDNLAETQKPEQSSLVPG---HLDQVNGQVVPEASQLSIKQEPREE 4422 Query: 320 -----AQEAPRKEEGATKKAPSRL-------PLPPSFHIRPASQVYPDRAPEPDCPGELK 367 AQ R+ G AP P + H+ + G Sbjct: 4423 PCALGAQSVKREANGEPIGAPGTSNHLLLAGPRSEAGHLLLQKLLRAKNVQLSTGRGSEG 4482 Query: 368 ATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPP 427 A + + + +++ P PL P + A+ L ++K Sbjct: 4483 LRAEINGHIDSKLAGLEQKLQGTPSNKEDAAARKPLTPKPKRVQKASDRLVSSRKKLRKE 4542 Query: 428 AGFTKTPK-----SSSPALKPKPNPPSPENTASSAPVDWRDP-SQMEKLRNEL--AAYLC 479 G + +L P P N + AP P + +LR A Sbjct: 4543 DGVRASEALLKQLKQELSLLPLTEPAITANFSLFAPFGSGCPVNGQSQLRGAFGSGALPT 4602 Query: 480 GSRREDRFL--SHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDT---PPGVPEKSLGG 534 G + L ++ P P S P + +K P+++ P Sbjct: 4603 GPDYYSQLLTKNNLSNPPTPPSSLPPTPPPSVQQKMVNGVTPSEELGEHPKDAASARDSE 4662 Query: 535 SSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSI-GSLPPK- 592 +L +T SL L + P + T VR +E S + SI G P+ Sbjct: 4663 RALRDTSEVKSLDLLAALPTPPHNQTEDVRMESDEDSDSPDSIVPASSPESILGEEAPRF 4722 Query: 593 PRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIP 652 P L GR +D+ PV +P S + P T +P LG +P K Sbjct: 4723 PHLGSGR----WEQEDRALSPVIPLIPRASIPVFPDT--KPYGALGLEVPGKL------- 4769 Query: 653 PKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEK--D 710 P T + G + T A A + ++L++ K + Sbjct: 4770 ----------------PVTTWEKGKGSEVSVMLTVSAAAAKNLNGVMVAVAELLSMKIPN 4813 Query: 711 SGPAGQPEKPASQEVSTPSQARGEGSPSEATRL--------PTQGARSSAAFPPKTSPGG 762 S PE PA + + P + EG + L P + A P T Sbjct: 4814 SYEVLFPESPA-RAGTEPKKGEAEGPGGKEKGLEGKSPDTGPDWLKQFDAVLPGYTLKSQ 4872 Query: 763 GEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDE 822 ++ L K + + P E PP P P ++ PT+ Sbjct: 4873 LDILSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEP 4932 Query: 823 LLRHPVTGEVVERGSPMALLLAARQRA--QKGRSVGAALGRSSLPGSLR 869 L+ P T + E P L LA+ + K R+ G S P L+ Sbjct: 4933 LVELP-TEPLAEPPVPSPLPLASSPESARPKPRARPPEEGEDSRPPRLK 4980 Score = 57.0 bits (136), Expect = 1e-07 Identities = 212/933 (22%), Positives = 289/933 (30%), Gaps = 181/933 (19%) Query: 195 EALSPPHTLSSPSIP--------TPPDFIPPAP----PLAFLAPPPPPVPAPAP------ 236 EA S PH L+ PS+ T P P P+ P PP P P Sbjct: 4126 EASSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPMQNNTGPQPPKPGPVLQSGQGL 4185 Query: 237 PAPASPHTVGTRLFPPGGVT-------------KWKSDVALNGRQAEATRASPPRSPAEP 283 P TVG GV + + L RQ + ++A P + Sbjct: 4186 PGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQE 4245 Query: 284 KGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPP- 342 G+ P P+ P P + P+QE PR + P RLP PP Sbjct: 4246 PGTQTSPLQGLLGCQPQLGGFPGP-----QTGPLQELGAGPRPQ------GPPRLPAPPG 4294 Query: 343 SFHIRPA-SQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPP-A 400 + P V+P P P P E K + +L SQ A PP P P P Sbjct: 4295 ALSTGPVLGPVHP--TPPPSSPQEPKRPS----QLPSPSSQLPTEAQLPPTHPGTPKPQG 4348 Query: 401 PPLPPPAPPLPPAAPPLPCAQKAA-----HPPAGFTKTPKSSSPALKPK----------- 444 P L PP + PAA L + PP +T K +L P Sbjct: 4349 PTLEPPPGRVSPAAAQLADTLFSKGLGPWDPPDNLAETQKPEQSSLVPGHLDQVNGQVVP 4408 Query: 445 -------PNPPSPENTASSAPVDWRD----PSQMEKLRNELAAYLCGSRREDRFLSHRP- 492 P E A A R+ P N L L G R E L + Sbjct: 4409 EASQLSIKQEPREEPCALGAQSVKREANGEPIGAPGTSNHLL--LAGPRSEAGHLLLQKL 4466 Query: 493 --GPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPS 550 V + G +G R + S A G+ +K G S E AA P Sbjct: 4467 LRAKNVQLSTGRGSEGLRAEINGHIDSKLA-----GLEQKLQGTPSNKEDAAARKPLTPK 4521 Query: 551 VDYIPQ--DSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDD 608 + + D S +++R E R S A K+ K + LP L I N + Sbjct: 4522 PKRVQKASDRLVSSRKKLRKEDGVRASEALLKQLKQELSLLP----LTEPAITANFS--- 4574 Query: 609 KLSKPVAKNLPPQSTTLLPTTSLQPKAMLGP-----AIPPKATPEPAIPPKATLWPATPP 663 L P P + L GP + P PP + P TPP Sbjct: 4575 -LFAPFGSGCPVNGQSQLRGAFGSGALPTGPDYYSQLLTKNNLSNPPTPPSSL--PPTPP 4631 Query: 664 KATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQ 723 P+ K +G T + P A++A K P Sbjct: 4632 -----PSVQQKMVNGVTPSEELGEHPKDAASARDSERALRDTSEVKSLDLLAALPTPPHN 4686 Query: 724 EVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSRE-- 781 + E S S + +P S G E P PH +E Sbjct: 4687 QTEDVRMESDEDSDSPDSIVPASSPESIL---------GEEAPRF--PHLGSGRWEQEDR 4735 Query: 782 -VAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA 840 ++ V+P + R P P P A + + PVT +GS ++ Sbjct: 4736 ALSPVIPLIPRASI------------PVFPDTKPYGALGLEVPGKLPVTTWEKGKGSEVS 4783 Query: 841 LLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVV-PKLP 899 ++L A K + G + + L S PNS+ V+ P+ P Sbjct: 4784 VMLTVSAAAAKNLN-GVMVAVAELL-------------------SMKIPNSYEVLFPESP 4823 Query: 900 KEAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGH- 958 A + P E G G EG +W K ++ V P + Sbjct: 4824 ARAGTE-PKKGEAEGPGGKEKG--LEGKSPDTGPDWLKQ-------FDAVLPGYTLKSQL 4873 Query: 959 ---PLPKSFSSPPSPSNKREEEEEEFNFEV----IPPPPEFSNDPEPPAPALQYLGRQSS 1011 L K S P P + N +V PPP E S P P AP+ +S Sbjct: 4874 DILSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPS------PAS 4927 Query: 1012 PPRNNYSDLRQLPNAGPGAPPALGFSRFPAGAR 1044 PP +L P A P P L + P AR Sbjct: 4928 PPTEPLVELPTEPLAEPPVPSPLPLASSPESAR 4960 Score = 46.6 bits (109), Expect = 1e-04 Identities = 172/778 (22%), Positives = 253/778 (32%), Gaps = 149/778 (19%) Query: 481 SRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETL------LSLPAKDTPPGVPEKSLGG 534 SR F S PG +P + G P P T LS + ++ LG Sbjct: 1955 SRERGGFFSPEPGEPDSPWTGSGGTTPSTPTTPTTEGEGDGLSYNQRSLQRWEKDEELGQ 2014 Query: 535 SSLTETEAAPSLTLPSV--DYIPQDSPTPSVRQIRNELEAR-----LSSAAEKEAKPSIG 587 S ++ P++ DY S + ++ ++ A L A + A I Sbjct: 2015 LSTISPVLYANINFPNLKQDYPDWSSRCKQIMKLWRKVPAADKAPYLQKAKDNRAAHRIN 2074 Query: 588 SLPPKPRLEGGRICENGADDDKLSKPVAK-NLPPQSTTL-LPTTSLQPKAMLGPAIPPKA 645 + + + + + G K +P +PPQ L P + P +G P Sbjct: 2075 KVQKQAESQINKQTKVGDIARKTDRPALHLRIPPQPGALGSPPPAAAPTIFIGSPTTPAG 2134 Query: 646 TPEPAI----PPKATL-WPATPPKA--TLGPATPLKATS------GPTTPLKATSGPAIA 692 A PP ++ P +P + L P P + S P PL+ P Sbjct: 2135 LSTSADGFLKPPAGSVPGPDSPGELFLKLPPQVPAQVPSQDPFGLAPAYPLE----PRFP 2190 Query: 693 STATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSA 752 + T P S P G P +P S+ G G P E P R Sbjct: 2191 TAPPTYPPYPS---------PTGAPAQPPMLGASSRP---GAGQPGEFHTTPPGTPRHQP 2238 Query: 753 AFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAK 812 + P KP C P+L + + V E PG+ Sbjct: 2239 STPDP----------FLKPRC-------------PSL---------DNLAVPESPGV--- 2263 Query: 813 PPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAA-LGRSSLPGSLRDH 871 + ++ LL P GE S AL + + S G LG P S H Sbjct: 2264 --GGGKASEPLLSPPPFGE-----SRKALEVKKEELGASSPSYGPPNLGFVDSPSS-GTH 2315 Query: 872 SHQAEASSDSIFHSQGTPNSFTVVPKLP------KEAEKDSPLTTEIPNKWGPRLGRDAE 925 E + +F + TP + V P+ P +E L P+ P + R Sbjct: 2316 LGGLELKTPDVFKAPLTPRASQVEPQSPGLGLRPQEPPPAQALAPSPPSH--PDIFRPGS 2373 Query: 926 GTELSRRHNWT-KPEPQAPVAWERVAPSNLPQGH-----PLPKSFSSPPSPSNKREEEEE 979 T+ + T +P+P P + + P +LP P+S SS SP R E Sbjct: 2374 YTDPYAQPPLTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAE 2433 Query: 980 EFNFEVIPP----PPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALG 1035 F + P P +S P P + PPR ++ AG A +LG Sbjct: 2434 AFCPSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHK-PPRPQPPEVAF--KAGSLAHTSLG 2490 Query: 1036 FSRFPAGARYAGAGGLERF--SGGGRSLIKKR-----------------LYVGEPHRGPG 1076 FPA AG L SG + ++ VGEP P Sbjct: 2491 AGGFPAALPAGPAGELHAKVPSGQPPNFVRSPGTGAFVGTPSPMRFTFPQAVGEPSLKPP 2550 Query: 1077 LPHGGTGRSLSSPNCFGPQP--GGPEMRR--VNSAGRAPPGGLHAPRLSLEGAARGAAEA 1132 +P G + FGP P G P+ V + P G P G + G + Sbjct: 2551 VPQPGLPPPHGINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPSSGSTGESYGLSPL 2610 Query: 1133 KHKA-------PGSADYGFAPAAGRSPYTT---------TRYGSPINTFTVRPGTRHP 1174 + + GS Y A+ RS T+ T GS + T + PGT+ P Sbjct: 2611 RPPSVLPPPAPDGSLPYLSHGASQRSGITSPVEKREDPGTGMGSSLATAEL-PGTQDP 2667 Score = 46.2 bits (108), Expect = 2e-04 Identities = 101/438 (23%), Positives = 152/438 (34%), Gaps = 63/438 (14%) Query: 621 QSTTLL-PTTSLQPKAMLGPAIPPKATPEPAIPPK--ATLWPATPPKATLGPATPLKATS 677 QS TLL P Q + LGP +P K + P TL + T+ PA +AT Sbjct: 3980 QSRTLLSPQQQQQQQVALGPGMPAKPLQHFSSPGALGPTLLLTGKEQNTVDPAVSSEATE 4039 Query: 678 GPTTPLKATSGP-AIASTATTLPTTTSQLMAEKDSG-------PAGQPEKPASQEVSTPS 729 GP+T GP AI +T ++ T ++ P QP+ P+S ++ P Sbjct: 4040 GPST---HQGGPLAIGTTPESMATEPGEVKPSLSGDSQLLLVQPQPQPQ-PSSLQLQPPL 4095 Query: 730 QARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTL 789 + G+ + + L T G S +S VP L Q S+S P Sbjct: 4096 RLPGQ-QQQQVSLLHTAGGGSHGQLGSGSSSEASSVPHLLA----QPSVS---LGDQPGS 4147 Query: 790 ARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRA 849 GP +P+ + P + QP P G V++ G + + Sbjct: 4148 MTQNLLGPQQPMLER-----PMQNNTGPQP-------PKPGPVLQSGQGLPGVGIMPTVG 4195 Query: 850 QKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTV--VPKLPKEAEKDSP 907 Q + L ++ LR S Q + ++ + S V P + + SP Sbjct: 4196 QLRAQLQGVLAKNP---QLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSP 4252 Query: 908 LTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWER-------------VAPSNL 954 L + + P+LG + P PQ P V P+ Sbjct: 4253 LQGLLGCQ--PQLGGFPGPQTGPLQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPP 4310 Query: 955 PQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPR 1014 P PK S PSPS++ E + PP P+P P L+ + SP Sbjct: 4311 PSSPQEPKRPSQLPSPSSQLPTEAQ--------LPPTHPGTPKPQGPTLEPPPGRVSPAA 4362 Query: 1015 NNYSDLRQLPNAGPGAPP 1032 +D GP PP Sbjct: 4363 AQLADTLFSKGLGPWDPP 4380 Score = 45.1 bits (105), Expect = 4e-04 Identities = 45/145 (31%), Positives = 57/145 (39%), Gaps = 12/145 (8%) Query: 161 SPLPSPPS------TAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDF 214 SP P PP+ L PPP +PPP P+ + + P T +PT P Sbjct: 4883 SPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPLA 4942 Query: 215 IPPAP-PLAFLAPPPPPVPAP-APPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEAT 272 PP P PL + P P P A P + RL GV +WK L Q + Sbjct: 4943 EPPVPSPLPLASSPESARPKPRARPPEEGEDSRPPRLKKWKGV-RWKRLRLLLTIQKGSG 5001 Query: 273 RASPPRSPA---EPKGSALGPNPEP 294 R R A E G+AL P+ P Sbjct: 5002 RQEDEREVAEFMEQLGTALRPDKVP 5026 Score = 43.9 bits (102), Expect = 0.001 Identities = 99/457 (21%), Positives = 139/457 (30%), Gaps = 102/457 (22%) Query: 130 PGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAP-----PPPPLLLEPPPPP 184 PG ++ P P P P PQ EP S LPSP S P PP P P Sbjct: 4293 PGALSTGPVLGPVHPTPPPSSPQ---EPKRPSQLPSPSSQLPTEAQLPPTHPGTPKPQGP 4349 Query: 185 SMAPPPPPVLEALS---------------PPHTLSSPSIPTPPDFIP-----------PA 218 ++ PPP V A + PP L+ P +P P Sbjct: 4350 TLEPPPGRVSPAAAQLADTLFSKGLGPWDPPDNLAETQKPEQSSLVPGHLDQVNGQVVPE 4409 Query: 219 PPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPG--------------------GVTKW 258 + P P G + PG + + Sbjct: 4410 ASQLSIKQEPREEPCALGAQSVKREANGEPIGAPGTSNHLLLAGPRSEAGHLLLQKLLRA 4469 Query: 259 KSDVALNGRQAEATRA------SPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRT 312 K+ GR +E RA + E K N E R P P V+ Sbjct: 4470 KNVQLSTGRGSEGLRAEINGHIDSKLAGLEQKLQGTPSNKED--AAARKPLTPKPKRVQK 4527 Query: 313 SSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAP- 371 +S + +++ RKE+G L + P + EP AP Sbjct: 4528 ASDRLVSSRKKLRKEDGVRASEALLKQLKQELSLLPLT--------EPAITANFSLFAPF 4579 Query: 372 --ASPRLGQSQSQADERAGTPPPA---------------PPLPPPA-PPLPPPAPPLPPA 413 P GQSQ + +G P PP PP + PP PPP+ Sbjct: 4580 GSGCPVNGQSQLRGAFGSGALPTGPDYYSQLLTKNNLSNPPTPPSSLPPTPPPSVQQKMV 4639 Query: 414 APPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNE 473 P + HP + + S AL+ S + A+ + +Q E +R E Sbjct: 4640 NGVTPSEELGEHPKD--AASARDSERALRDTSEVKSLDLLAA---LPTPPHNQTEDVRME 4694 Query: 474 LAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLP 510 ED P +P+S G++ PR P Sbjct: 4695 --------SDEDSDSPDSIVPASSPESILGEEAPRFP 4723 Score = 40.4 bits (93), Expect = 0.010 Identities = 44/198 (22%), Positives = 68/198 (34%), Gaps = 40/198 (20%) Query: 273 RASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATK 332 R S P PA P S++ N + ++F P P S+P+Q+ Q+ +++ AT Sbjct: 2771 RLSRPPPPATP--SSMDVNSRQLVGGSQAFYQRAPYP---GSLPLQQQQQQLWQQQQATA 2825 Query: 333 KAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQS------QSQADER 386 R + F P ++ P + P P G + + + + + Sbjct: 2826 ATSMRFAMSARFPSTPGPELGRQALGSPLAGISTRLPGPGEPVPGPAGPAQFIELRHNVQ 2885 Query: 387 AGTPPPAPPLPPPAPPLPPP-----------------------APPLPPAAPPLPCAQKA 423 G P P P PP P PP P+APP P + Sbjct: 2886 KGLGPGGTPFPGQGPPQRPRFYPVSEDPHRLAPEGLRGLAVSGLPPQKPSAPPAPELNNS 2945 Query: 424 AHPPAGFTKTPKSSSPAL 441 HP TP + P L Sbjct: 2946 LHP------TPHTKGPTL 2957 Score = 40.4 bits (93), Expect = 0.010 Identities = 136/636 (21%), Positives = 211/636 (33%), Gaps = 121/636 (19%) Query: 427 PAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDR 486 P TP+S A +P PS + V + Q L+ + L G +++ Sbjct: 4048 PLAIGTTPESM--ATEPGEVKPSLSGDSQLLLVQPQPQPQPSSLQLQPPLRLPGQQQQQV 4105 Query: 487 FLSHRPGPTVAPQSKEGK--KGPRLPEKETLLSLPAKDTPPGVPEKSLGG---------- 534 L H G Q G + +P S+ D P + + LG Sbjct: 4106 SLLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPMQ 4165 Query: 535 SSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPR 594 ++ P L S +P P+V Q+R +L+ L+ P + L P+ + Sbjct: 4166 NNTGPQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAK------NPQLRHLSPQQQ 4219 Query: 595 LEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQ------------PKAMLGPAIP 642 + + + PP T+ LQ P GP Sbjct: 4220 QQLQALL---MQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFPGPQTGPLQE 4276 Query: 643 PKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTT 702 A P P PP+ PA P + GP GP P S P + LP+ + Sbjct: 4277 LGAGPRPQGPPRL---PAPPGALSTGPVL------GPVHPTPPPSSPQEPKRPSQLPSPS 4327 Query: 703 SQLMAE-----------KDSGPAGQPE----KPASQEVSTPSQARGEGSPSEATRL-PTQ 746 SQL E K GP +P PA+ +++ ++G G L TQ Sbjct: 4328 SQLPTEAQLPPTHPGTPKPQGPTLEPPPGRVSPAAAQLADTLFSKGLGPWDPPDNLAETQ 4387 Query: 747 GARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEP 806 S+ P G+V P Q S+ +E R G +E Sbjct: 4388 KPEQSSLVPGHLDQVNGQV----VPEASQLSIKQE--------PREEPCALGAQSVKREA 4435 Query: 807 PGLPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSS--L 864 G P P ++ LL P R LLL Q+ + ++V + GR S L Sbjct: 4436 NGEPIGAPGTSNHL--LLAGP-------RSEAGHLLL---QKLLRAKNVQLSTGRGSEGL 4483 Query: 865 PGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRDA 924 + H A + QGTP++ ++A PLT + P+ + A Sbjct: 4484 RAEINGHIDSKLAGLEQ--KLQGTPSN-------KEDAAARKPLTPK------PKRVQKA 4528 Query: 925 EGTELSRRHNWTKPE----PQAPVAWERVAPSNLPQGHP-LPKSFS-----SPPSPSNKR 974 +S R K + +A + + S LP P + +FS P N + Sbjct: 4529 SDRLVSSRKKLRKEDGVRASEALLKQLKQELSLLPLTEPAITANFSLFAPFGSGCPVNGQ 4588 Query: 975 EEEEEEFNFEVIPPPPEF----------SNDPEPPA 1000 + F +P P++ SN P PP+ Sbjct: 4589 SQLRGAFGSGALPTGPDYYSQLLTKNNLSNPPTPPS 4624 Score = 38.9 bits (89), Expect = 0.029 Identities = 36/114 (31%), Positives = 45/114 (39%), Gaps = 28/114 (24%) Query: 142 PPPGPAPGPPQDISEP--------PGGSPLPSP-PSTAPPPPPLLLEP------------ 180 P PGPA GP Q I PGG+P P P P P+ +P Sbjct: 2867 PVPGPA-GPAQFIELRHNVQKGLGPGGTPFPGQGPPQRPRFYPVSEDPHRLAPEGLRGLA 2925 Query: 181 ----PPPPSMAPPPPPVLEALSP-PHTLSSPSIPTPPDFIPPAPPLAFLAPPPP 229 PP APP P + +L P PHT P++PT + + P L P P Sbjct: 2926 VSGLPPQKPSAPPAPELNNSLHPTPHT-KGPTLPTGLELVNRPPSSTELGRPNP 2978 Score = 31.6 bits (70), Expect = 4.7 Identities = 82/323 (25%), Positives = 103/323 (31%), Gaps = 71/323 (21%) Query: 173 PPPLLLEPPPPPSMAPPPPPVLEALSP--PHTLSSPSIPTPPDFIPPAPPLAFLAPPPPP 230 P PL E PPP+ P + L P P+P F P P Sbjct: 3091 PGPLGPEERPPPAADASEPRLASVLPEVKPKVEEGGRHPSPCQF-------TIATPKVEP 3143 Query: 231 VPA---------PAPPAPASPHT-VGTRLFPPGGVTKWKSDV-ALNGRQAEATRASPPRS 279 PA P S T +GT F G T K+ A G A SP Sbjct: 3144 APAANSLGLGLKPGQSMMGSRDTRMGTGPFSSSGHTAEKASFGATGGPPAHLLTPSPLSG 3203 Query: 280 PAEPKGSALGPNPEPH---LTFP-------------RSFKVPPPTPVRTSSIPVQEAQEA 323 P GS+L E LT P S V P+ + E +E Sbjct: 3204 PG---GSSLLEKFELESGALTLPGGPAASGDELDKMESSLVASELPLLIEDLLEHEKKEL 3260 Query: 324 PRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEP--DCPGELKATA----PASPRLG 377 +K++ S ++PA Q + PG +A + +SP L Sbjct: 3261 QKKQQ-------------LSAQLQPAQQQQQQQQQHSLLSAPGPAQAMSLPHEGSSPSLA 3307 Query: 378 QSQSQAD-ERAGTPPPAPPLPPPAPPLPPPAPPLPP-AAPPLPCAQKAAHPPAG------ 429 SQ Q AG P LP P P PPA L AP + H +G Sbjct: 3308 GSQQQLSLGLAGARQPG--LPQPLMPTQPPAHALQQRLAPSMAMVSNQGHMLSGQHGGQA 3365 Query: 430 FTKTPKSSSPALKPKP---NPPS 449 +SS P L KP PPS Sbjct: 3366 GLVPQQSSQPVLSQKPMGTMPPS 3388 >gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens] Length = 1682 Score = 124 bits (312), Expect = 4e-28 Identities = 235/991 (23%), Positives = 330/991 (33%), Gaps = 208/991 (20%) Query: 138 LIPPPPPGPAPGPPQDISEPPGGSPLPS--------PPSTAPPPPPLLLEPPPPPSMAPP 189 ++ P PP GP + PGG PP PPPPL PPPPP PP Sbjct: 205 VVQPVPPAALSGPSGEEGLSPGGKRRRGCNSEQTGLPPGLPLPPPPL--PPPPPPPPPPP 262 Query: 190 PPPVLEALSPPHTLSSP----------------------------SIPTPPDFIPPA--- 218 PP A SPP L+ P S+P P + PA Sbjct: 263 PPLPGLATSPPFQLTKPGLWSTLHGDAWGPERKGSAPPERQEQRHSLPHPYPYPAPAYTA 322 Query: 219 -PPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGG------VTKWKSDVALNGRQAEA 271 PP L P PP P P PP A H PPG V + + D +++ A Sbjct: 323 HPPGHRLVPAAPPGPGPRPPG-AESHGCLPATRPPGSDLRESRVQRSRMDSSVS---PAA 378 Query: 272 TRASPPRSPAEPKG---------SALGPNP-----EPHLTFPRSFKVPPPTPVRTSSIPV 317 T A P +P+ P G S+ N EP+ P + P + + Sbjct: 379 TTACVPYAPSRPPGLPGTTTSSSSSSSSNTGLRGVEPNPGIPGADHYQTPALEVSHHGRL 438 Query: 318 QEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLG 377 + + RK A L LPP P P P CP L+ P + G Sbjct: 439 GPSAHSSRKPFLGAPAATPHLSLPPG----------PSSPPPPPCPRLLRPPPPPAWLKG 488 Query: 378 QSQSQADERA--------GTPPPAPPLPPPAPP----LPPPAPPL--------PPAAPPL 417 + A E GT P P PPP P L PPA P PP Sbjct: 489 PACRAAREDGEILEELFFGTEGPPRPAPPPLPHREGFLGPPASRFSVGTQDSHTPPTPPT 548 Query: 418 PCAQKA-------AHPPAGFTKTPKSS--SPALKPKPNPPSPENTASSAPVDWRDPSQME 468 P + + PAG P + ++ P P PPSP P+ + Sbjct: 549 PTTSSSNSNSGSHSSSPAGPVSFPPPPYLARSIDPLPRPPSPAQNPQDPPLVPLTLALPP 608 Query: 469 KLRNELAAYLCGSRREDRFLSHRPGPTVA-PQSKEGKKGPRLPEKETLLSLPAKDTPPGV 527 + GS R P P V+ P++ E GP LS + PPGV Sbjct: 609 APPSSCHQNTSGSFRR----PESPRPRVSFPKTPEVGPGP----PPGPLSKAPQPVPPGV 660 Query: 528 PEKSLGGSSLTETEAAP---SLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKP 584 E G L + P P+ I D ++ + + E++ + Sbjct: 661 GELPARGPRLFDFPPTPLEDQFEEPAEFKILPDGLANIMKMLDESIRKE-----EEQQQH 715 Query: 585 SIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSL---QPKAMLGPAI 641 G P P E ++ D A + +TT TT+ + + PA+ Sbjct: 716 EAGVAPQPPLKEPFASLQSPFPTDTAPTTTAPAVAVTTTTTTTTTTTATQEEEKKPPPAL 775 Query: 642 PPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLK---ATSGPAIASTATTL 698 PP P PP + P PP PA+ LK+ + K +G A+++ L Sbjct: 776 PP-PPPLAKFPPPSQ--PQPPPPPPPSPASLLKSLASVLEGQKYCYRGTGAAVSTRPGPL 832 Query: 699 PTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQG---ARSSAA-- 753 PTT Q SG P A+ +Q + S S +++ T G AR A Sbjct: 833 PTT--QYSPGPPSGATALPPTSAAPS----AQGSPQPSASSSSQFSTSGGPWARERRAGE 886 Query: 754 --FPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLAR---GGAAGPGEPVEVKEPPG 808 P +P P P +S + E++ TL A P +PV+ EP Sbjct: 887 EPVPGPMTPTQPPPPLSLPPARSESEVLEEISRACETLVERVGRSATDPADPVDTAEPAD 946 Query: 809 LPAK---PPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLP 865 + PPA A+ E +A + + +R QK Sbjct: 947 SGTERLLPPAQAK---------------EEAGGVAAVSGSCKRRQKEHQ----------- 980 Query: 866 GSLRDHSHQAEASSDSIFH--SQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRD 923 ++H A DS+ +G + VPK EK + + + GR+ Sbjct: 981 ---KEHRRHRRACKDSVGRRPREGRAKAKAKVPK-----EKSRRVLGNLDLQSEEIQGRE 1032 Query: 924 AEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNF 983 +L KP P AP P P P + +PPS S ++ EE Sbjct: 1033 KSRPDLGGASK-AKP-PTAPA----------PPSAPAPSAQPTPPSASVPGKKAREE--- 1077 Query: 984 EVIPPPPEFSNDPEPPAPALQYLGRQSSPPR 1014 P PP S A L+ PP+ Sbjct: 1078 --APGPPGVSR-----ADMLKLRSLSEGPPK 1101 Score = 58.9 bits (141), Expect = 3e-08 Identities = 87/360 (24%), Positives = 122/360 (33%), Gaps = 42/360 (11%) Query: 60 TVSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNL 119 T + + TAT + + P L P A+ P P + +S++ G Sbjct: 756 TTTTTTTATQEEEKKPPPALPPPPPLAKFPPPSQPQPPPPPPPSPASLLKSLASVLEGQK 815 Query: 120 RLYSSVG---DLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTA------ 170 Y G RPG P PP G PP + GSP PS S++ Sbjct: 816 YCYRGTGAAVSTRPGPLPTTQYSPGPPSGATALPPTSAAPSAQGSPQPSASSSSQFSTSG 875 Query: 171 ------------PPPPPLLLEPPPPPSMAPP---PPPVLEALSPP-HTLSSPSIPTPPDF 214 P P P+ PPPP PP VLE +S TL + D Sbjct: 876 GPWARERRAGEEPVPGPMTPTQPPPPLSLPPARSESEVLEEISRACETLVERVGRSATD- 934 Query: 215 IPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRA 274 PA P+ P PPA A G + K + R A + Sbjct: 935 --PADPVDTAEPADSGTERLLPPAQAKEEAGGVAAVSGSCKRRQKEHQKEHRRHRRACKD 992 Query: 275 SPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKE-EGATKK 333 S R P E + A P+ +S +V +++ I + +E R + GA+K Sbjct: 993 SVGRRPREGRAKAKAKVPK-----EKSRRVLGNLDLQSEEI---QGREKSRPDLGGASKA 1044 Query: 334 APSRLPLPPSFHIRPASQVYPDRAPEPDCPG-ELKATAPASPRLGQSQSQADERAGTPPP 392 P P PPS PA P P PG + + AP P + ++ PP Sbjct: 1045 KPPTAPAPPS---APAPSAQP-TPPSASVPGKKAREEAPGPPGVSRADMLKLRSLSEGPP 1100 >gi|47132519 Ras association and pleckstrin homology domains 1 isoform 1 [Homo sapiens] Length = 1250 Score = 122 bits (306), Expect = 2e-27 Identities = 155/617 (25%), Positives = 225/617 (36%), Gaps = 122/617 (19%) Query: 182 PPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPAS 241 P S+ PP P + ++P +T S PS P PP PP PP PPPPP+P+ + P+ S Sbjct: 601 PYTSLVPPLSPQPKIVTP-YTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGS 659 Query: 242 PHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRS 301 + + +T+ + N Q PP P S +P + P + Sbjct: 660 AAPMFVKY---STITRLQ-----NASQHSGALFKPPTPPVMQSQSV-----KPQILVPPN 706 Query: 302 FKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVY----PDRA 357 VPPP P P + A K P PP I + P Sbjct: 707 GVVPPPPP--PPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPP 764 Query: 358 PEPDCPGELKATAPASPRL-------GQSQSQADERAGTPPPAPPLPP----PAPPLP-- 404 P P P L AP P + ++ + +A P P PP+PP PA P Sbjct: 765 PPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYI 824 Query: 405 PPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDP 464 PP+PP PP P P PK S KP P+P SP P Sbjct: 825 PPSPPTPPVPVPPP-------------TLPKQQSFCAKPPPSPLSPV------------P 859 Query: 465 SQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTP 524 S ++++ ++ E + L P VAPQS K + + + + +P+ D P Sbjct: 860 SVVKQIASQFPPPPTPPAMESQPLKPVPA-NVAPQSPPAVKA-KPKWQPSSIPVPSPDFP 917 Query: 525 PGVPEKSLGGSSLTETEAAPS-LTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAK 583 P PE SSL PS + P P SPTP + ++ SS K K Sbjct: 918 PPPPE-----SSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGK--K 970 Query: 584 PSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPP 643 P PP P+ +GA+ + +P +L + T + S + + PA PP Sbjct: 971 P-----PPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPP 1025 Query: 644 K---------------------------------ATPEPAIPPKATLWPATPPKATLGPA 670 K + E PP + +P PP+ L P Sbjct: 1026 KPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETEL-PL 1084 Query: 671 TPLK---ATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVST 727 P++ SG T+P A P P S++ +K A P +P + + Sbjct: 1085 PPIEIPAVFSGNTSPKVAVVNPQ--------PQQWSKMSVKK----APPPTRPKRNDSTR 1132 Query: 728 PSQARGEGSPSEATRLP 744 +QA P+ AT +P Sbjct: 1133 LTQAEISEQPTMATVVP 1149 Score = 121 bits (303), Expect = 5e-27 Identities = 161/605 (26%), Positives = 224/605 (37%), Gaps = 155/605 (25%) Query: 138 LIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSM----------- 186 L+PP P P P S+P P P PP PPPPP PPPPP + Sbjct: 605 LVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPP----PPPPPPLPSQSAPSAGSA 660 Query: 187 ------------------------APPPPPVLEALS--------------------PPHT 202 PP PPV+++ S PP T Sbjct: 661 APMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPT 720 Query: 203 LSS--------PSIPTPPDFIPPAPPLAF------------LAPPPPPVPAPAPP-APAS 241 S P P+ P F P PPL PPPPP+PAP PP AP Sbjct: 721 PGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPK 780 Query: 242 PHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRS 301 P P TK + V T+A+PP +P P P + FP S Sbjct: 781 PLVT----IPAPTSTKTVAPV--------VTQAAPP-TPTPPV-----PPAKKQPAFPAS 822 Query: 302 FKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPD 361 + +PP P T +PV P+++ K PS L PS + ASQ P P Sbjct: 823 Y-IPPSPP--TPPVPV-PPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAM 878 Query: 362 CPGELKA----TAPASPRLGQSQSQADERAGTPPPAPPLPPPAP------PLPPPAP-PL 410 LK AP SP +++ + + + P P+P PPP P P PPP+P P Sbjct: 879 ESQPLKPVPANVAPQSPPAVKAKPKW-QPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPA 937 Query: 411 PPAAPP---LPCAQKAAHPPAGFTKTPKSSSP-ALKPKPNPPSPENTASSAPVDWRDPSQ 466 PP PP P K+ P KT K+SSP KP P P + SS+ + +P + Sbjct: 938 PPPPPPPTASPTPDKSGSPG---KKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKR 994 Query: 467 MEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQ-SKEGKKGPRLP---------EKETLL 516 + + ++ + + P P P+ K G LP K +L Sbjct: 995 -PSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVL 1053 Query: 517 SLPAKDTP---PGVPEKSLGGSSLTETE-AAPSLTLPSVDYIPQDSPTPSVRQIRNELEA 572 S KD+ P P S ETE P + +P+V + SP +V Sbjct: 1054 SGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAV-FSGNTSPKVAV--------- 1103 Query: 573 RLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQ 632 ++ ++ +K S+ PP R + D +L++ P + T++P Sbjct: 1104 -VNPQPQQWSKMSVKKAPPPTRPKRN-------DSTRLTQAEISEQPTMA-TVVPQVPTS 1154 Query: 633 PKAML 637 PK+ L Sbjct: 1155 PKSSL 1159 Score = 97.1 bits (240), Expect = 9e-20 Identities = 157/654 (24%), Positives = 227/654 (34%), Gaps = 124/654 (18%) Query: 306 PPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGE 365 P VR+ SI EA ++ + + +R+ RP + + P +P+P Sbjct: 563 PAGHVRSQSIVSSVFSEAWKRGTQLEESSKARMESMN----RPYTSLVPPLSPQPKIVTP 618 Query: 366 LKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPP--------- 416 A+ P+ P PPP PP PPP PP PPP PPLP + P Sbjct: 619 YTASQPSPP--------------LPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMF 664 Query: 417 -----LPCAQKAAHPPAGFTKTPK---SSSPALKPK-----------PNPPSPENTASSA 457 + Q A+ K P S ++KP+ P PP P T SA Sbjct: 665 VKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSA 724 Query: 458 PVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLS 517 + L A + + ++ PT P P + L++ Sbjct: 725 MAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVT 784 Query: 518 LPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSV-----------DYIPQDSPTPSVRQI 566 +PA + V + T+AAP P V YIP PTP V Sbjct: 785 IPAPTSTKTV--------APVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVP 836 Query: 567 RNELEARLSSAAEKEAKP----------SIGSLPPKPRLEGGRICENGADDDKLSKPVAK 616 L + S A+ P PP P A + + KPV Sbjct: 837 PPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPP--------TPPAMESQPLKPVPA 888 Query: 617 NLPPQSTTLLPTTSLQPKAMLGPAIPPKATPE-PAIPPKATL-WPATPPKATLGPATPLK 674 N+ PQS P +PK P+ P +P+ P PP+++L +P PP P P Sbjct: 889 NVAPQSP---PAVKAKPKWQ--PSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPP 943 Query: 675 ATSGPTTPLKATSGPAIASTAT----TLPTTTSQLMAEKDSGPAGQPE--KPASQE-VST 727 T+ PT + G + T++ P T + + K S A PE +P+ VS Sbjct: 944 PTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSK 1003 Query: 728 PSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMP 787 + GSPS+ T LP A P K + G +P + + C V+ P Sbjct: 1004 FTPPAESGSPSKET-LPPPAAPPK---PGKLNLSGVNLPGVLQQGC--------VSAKAP 1051 Query: 788 TLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQ 847 L+ G VE PP PP P EL P+ V G+ + Sbjct: 1052 VLS---GRGKDSVVEFPSPPSDSDFPP--PPPETELPLPPIEIPAVFSGNTSPKVAVVNP 1106 Query: 848 RAQKGRSVGAALGRSSLPGSLRDHSH--QAEASSDSIFHSQGTPNSFTVVPKLP 899 + Q+ + D + QAE S P TVVP++P Sbjct: 1107 QPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQ--------PTMATVVPQVP 1152 Score = 60.5 bits (145), Expect = 9e-09 Identities = 85/345 (24%), Positives = 115/345 (33%), Gaps = 89/345 (25%) Query: 139 IPPPPPGPAPGPPQD--ISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAP-------- 188 IP P P P PP+ + PP SP+P+P PPPPP P P S +P Sbjct: 909 IPVPSPDFPPPPPESSLVFPPPPPSPVPAP----PPPPPPTASPTPDKSGSPGKKTSKTS 964 Query: 189 -----PPPPVLEALSPPHTLSSPSIPTP---------PDFIPPA---PPLAFLAPPPPPV 231 PPP + S + S P P F PPA P PPP Sbjct: 965 SPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPP--- 1021 Query: 232 PAPAPPAPASPHTVGTRL---FPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSAL 288 APP P + G L G V+ ++ G+ + SPP P Sbjct: 1022 --AAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPE 1079 Query: 289 GPNPEPHLTFPRSFK--------VPPPTPVRTSSIPVQEA--------QEAPRKEEGATK 332 P P + P F V P P + S + V++A ++ R + Sbjct: 1080 TELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEIS 1139 Query: 333 KAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASP-----RLGQSQSQADERA 387 + P+ + P P S + + +P +L T L S+A+ A Sbjct: 1140 EQPTMATVVPQVPTSPKSSL----SVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTA 1195 Query: 388 GTPPPAPPLPPPAPPL-----------------------PPPAPP 409 A LPPP P L PPPAPP Sbjct: 1196 TMDDMA--LPPPPPELLSDQQKAGYGGSHISGYATLRRGPPPAPP 1238 Score = 53.9 bits (128), Expect = 9e-07 Identities = 126/565 (22%), Positives = 177/565 (31%), Gaps = 77/565 (13%) Query: 602 ENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPAT 661 + G ++ SK +++ T+L+P S QPK + TP A P L P Sbjct: 582 KRGTQLEESSKARMESMNRPYTSLVPPLSPQPKIV---------TPYTASQPSPPLPPPP 632 Query: 662 PPKATLGPATPLKATSGPTTPLKATSGPAIASTATTL---PTTTSQLMAEKDSGPAGQPE 718 PP P P P PL + S P+ S A T T A + SG +P Sbjct: 633 PP-----PPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPP 687 Query: 719 KPA---SQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKP---- 771 P SQ V G P SA K +P +P P Sbjct: 688 TPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPL 747 Query: 772 HCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQ-PTDELLRHPVTG 830 HQ +VA P P P+ PP P KP + PT PV Sbjct: 748 KIHQVQHITQVAPPTPP--------PPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVT 799 Query: 831 EVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPN 890 + + A +Q A + + +P Q F ++ P+ Sbjct: 800 QAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQS------FCAKPPPS 853 Query: 891 SFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVA 950 + VP + K+ P P P + + +P PV VA Sbjct: 854 PLSPVPSVVKQIASQFP-----PPPTPPAM----------------ESQPLKPVP-ANVA 891 Query: 951 PSNLPQGHPLPK-SFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQ 1009 P + P PK SS P PS E + PPPP P PP P Sbjct: 892 PQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPT----AS 947 Query: 1010 SSPPRNNYSDLRQLPNAGPGA--PPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLY 1067 +P ++ + + PG PP R + +GA E SL+ K Sbjct: 948 PTPDKSGSPGKKTSKTSSPGGKKPPPTP-QRNSSIKSSSGAEHPEPKRPSVDSLVSKFT- 1005 Query: 1068 VGEPHRGPGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPRLSLEGAAR 1127 P G + P P+PG + VN G G + A L G + Sbjct: 1006 -------PPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGK 1058 Query: 1128 GAAEAKHKAPGSADYGFAPAAGRSP 1152 + P +D+ P P Sbjct: 1059 DSVVEFPSPPSDSDFPPPPPETELP 1083 Score = 35.4 bits (80), Expect = 0.33 Identities = 47/196 (23%), Positives = 71/196 (36%), Gaps = 51/196 (26%) Query: 854 SVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIP 913 S+ + SS+P S +HS+Q++ S S G S ++V + EA K Sbjct: 533 SIKSGSSSSSIPESQSNHSNQSD-SGVSDTQPAGHVRSQSIVSSVFSEAWKR-------- 583 Query: 914 NKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNK 973 G E + +R + +P + + P PQ + +S PSP Sbjct: 584 -------GTQLEESSKARMESMNRP-------YTSLVPPLSPQPKIVTPYTASQPSPP-- 627 Query: 974 REEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNN-------YSDLRQLPNA 1026 + PPPP P PP P L QS+P + YS + +L NA Sbjct: 628 -----------LPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNA 676 Query: 1027 G--------PGAPPAL 1034 P PP + Sbjct: 677 SQHSGALFKPPTPPVM 692 >gi|189181724 proteoglycan 4 isoform D [Homo sapiens] Length = 1270 Score = 119 bits (299), Expect = 1e-26 Identities = 195/819 (23%), Positives = 282/819 (34%), Gaps = 126/819 (15%) Query: 21 TTPSTSLYATNPPWIFTQEAPEEGTG-GFDGIYYGDNRFNTVSESGTATLKARPRVRPLL 79 T+ TSL + T+E DG + T S T+ P + L Sbjct: 136 TSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLA 195 Query: 80 TFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLRLYSSVGDLRPGQYGQDLLI 139 P G A+ TP P KE T+ + S+ Sbjct: 196 KPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSA--------------- 240 Query: 140 PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPP-----PPVL 194 P P PAP + P P+P +T P P EP P + P P P Sbjct: 241 PTTPKEPAPTTTKSAPTTPKE---PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTT 297 Query: 195 EALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASP-HTVGTRLFPPG 253 P T P+ TP + P P P P P PAP +P T P Sbjct: 298 PKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPA 357 Query: 254 GVTKWKSDVALNGRQAEATRASP-PRSPAEPKGSALGPNP----EPHLTFPRSFKVPP-- 306 T + A T P P +P EP + P EP T +S P Sbjct: 358 PTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE 417 Query: 307 PTPVRTS----SIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDC 362 P+P T + P + A P+K T K P+ P P ++ P+ Sbjct: 418 PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA--PTTPKEPAPTTTKKPAPTTPKEPA 475 Query: 363 PGELKATAPASPRLGQSQSQADERAGTPP--PAPPLP----PPAPPLPPPAPPLPPAAPP 416 P K TAP +P+ + + ++ A T P PAP P P P P P P P AP Sbjct: 476 PTTPKETAPTTPK-KLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEP-APT 533 Query: 417 LPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTA-----SSAPVDWRDPSQMEKLR 471 P A P TPK +P +P P +P+ TA +AP ++P+ + Sbjct: 534 TPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKK 593 Query: 472 ---NELAAYLCGSRREDRFLSHRPGPT----VAPQSKEGKKGPRLPEK----------ET 514 ELA ++ +P PT AP + + + P P++ T Sbjct: 594 PAPKELAP--TTTKEPTSTTCDKPAPTTPKGTAPTTPK-EPAPTTPKEPAPTTPKGTAPT 650 Query: 515 LLSLPAKDTPPGVPEKSL------GGSSLTETEAAPSL---TLPSVDYIP---------- 555 L PA TP K L G +S T + AP+ T P+ P Sbjct: 651 TLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAP 710 Query: 556 --QDSPTPSVRQIRNELEARLSSAAEK---EAKPSIGSLPPKPRLEGGRICENGADDDK- 609 ++P P+ ++ + + K E+ P + + P LE E G K Sbjct: 711 TTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSP-KEPGVPTTKT 769 Query: 610 --LSKPVAKNLPPQST------TLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPAT 661 +KP T T TT+ PK A + T E I T +T Sbjct: 770 PAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTST 829 Query: 662 PPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPA 721 + T TP K T+ TT T P + +T T+ TT E+ + P ++ Sbjct: 830 TTQDT----TPFKITTLKTT----TLAPKVTTTKKTITTTEIMNKPEETAKP---KDRAT 878 Query: 722 SQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSP 760 + + +TP + P++A + PT + PKT P Sbjct: 879 NSKATTPKPQK----PTKAPKKPTSTKK------PKTMP 907 Score = 119 bits (298), Expect = 2e-26 Identities = 176/711 (24%), Positives = 246/711 (34%), Gaps = 121/711 (17%) Query: 140 PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPP------PSMAPPPPPV 193 P P PAP P+ EP +P P+T P P EP P P+ P P Sbjct: 311 PTTPKEPAPTTPK---EPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPT 367 Query: 194 LEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAP-----APPAPASPHTVGTR 248 P T PS TP + PAP AP PAP AP P P T+ Sbjct: 368 TPKEPAPTTTKEPSPTTPKE---PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTK 424 Query: 249 LFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPT 308 P T + + A T P +P PK A +P T P+ + P T Sbjct: 425 --EPAPTTPKEPAPTTPKKPAPTTPKEP--APTTPKEPAPTTTKKPAPTTPK--EPAPTT 478 Query: 309 PVRTS-SIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPD-RAPEPDCPGEL 366 P T+ + P + P K T + P+ P P + P + P PE P Sbjct: 479 PKETAPTTPKKLTPTTPEKLAPTTPEKPA--PTTPE-ELAPTTPEEPTPTTPEEPAPTTP 535 Query: 367 KATAPASPRLGQSQSQADERAGTPP-PAPPLPPPAPPLPP----------PAPPLPPAAP 415 KA AP +P+ + + TP PAP P P P PAP P Sbjct: 536 KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPA 595 Query: 416 PLPCAQKAAHPPAGFT------KTPKSSSPALKPKPNP-----PSPENTASSAPVDWRDP 464 P A P T TPK ++P +P P P+P +AP ++P Sbjct: 596 PKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEP 655 Query: 465 SQMEKLR---NELAAYLCGSRREDRFLSHRPGPTV----APQSKEGKKGPRLPEKETLLS 517 + + ELA ++ S +P PT AP + + + P P+K Sbjct: 656 APTTPKKPAPKELAPTT--TKGPTSTTSDKPAPTTPKETAPTTPK-EPAPTTPKK----- 707 Query: 518 LPAKDTPPGVPEKSLGGSSLTET-----------EAAPSL----TLPSVDYIPQDSPTPS 562 PA TP P + S+ T T E+ P L T +++ P++ P+ Sbjct: 708 -PAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPT 766 Query: 563 VRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKL--SKPVAKNLPP 620 + ++A +K + + + P E +K SK A Sbjct: 767 TKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQV 826 Query: 621 QSTTLLPTTSLQPKAMLGPAIPPKAT--------------PEPAIPPK--ATLWPATPPK 664 STT TT + + + PK T PE PK AT AT PK Sbjct: 827 TSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPK 886 Query: 665 ATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQE 724 P P KA PT+ K + P + TT PT + P + + Q Sbjct: 887 ----PQKPTKAPKKPTSTKKPKTMPRVRKPKTT-PTPRKMTSTMPELNPTSRIAEAMLQT 941 Query: 725 VSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGG--GEVP-CLYKPH 772 + P+Q T ++ P GG GE P L +PH Sbjct: 942 TTRPNQ--------------TPNSKLVEVNPKSEDAGGAEGETPHMLLRPH 978 Score = 114 bits (285), Expect = 6e-25 Identities = 188/762 (24%), Positives = 261/762 (34%), Gaps = 156/762 (20%) Query: 164 PSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAF 223 P+P + P L P P P P P T + TP + PAP Sbjct: 197 PTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKE---PAPTTTK 253 Query: 224 LAPPPPPVPAPAP---PAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSP 280 AP P PAP PAP +P T KS A T P +P Sbjct: 254 SAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKP--AP 311 Query: 281 AEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPL 340 PK A EP T P+ + P T + P + A AP+K T K P+ Sbjct: 312 TTPKEPAPTTPKEPTPTTPK--EPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA---- 365 Query: 341 PPSFHIRPASQVYPDRAPEPDCPGE-LKATAPASPRLGQSQSQADERAGTPPPAPPLPP- 398 P+ PA + P P P E T ++P + + ++ P P P Sbjct: 366 -PTTPKEPAPTT--TKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTT 422 Query: 399 ---PAPPLPP-PAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTA 454 PAP P PAP P P P K P TPK +P KP P +P+ A Sbjct: 423 TKEPAPTTPKEPAPTTPKK--PAPTTPKEPAPT-----TPKEPAPTTTKKPAPTTPKEPA 475 Query: 455 SSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKET 514 + P + P+ +KL P + E K P PEK Sbjct: 476 PTTPKETA-PTTPKKL--------------------------TPTTPE-KLAPTTPEK-- 505 Query: 515 LLSLPAKDTP----PGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNEL 570 PA TP P PE+ + T E AP+ + P++ P P+ Sbjct: 506 ----PAPTTPEELAPTTPEEP---TPTTPEEPAPTTPKAAAPNTPKE-PAPTT------- 550 Query: 571 EARLSSAAEKEAKPSIGSLP-PKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTT 629 KE P+ P P E G L +P PTT Sbjct: 551 --------PKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPA------------PTT 590 Query: 630 SLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGP 689 PK + P T EP P TP K T P TP + PTTP + P Sbjct: 591 ---PKKPAPKELAPTTTKEPTSTTCDKPAPTTP-KGT-APTTPKEPA--PTTPKE----P 639 Query: 690 AIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGAR 749 A + T PTT K+ P P+KPA +E++ P+ +G S + PT Sbjct: 640 APTTPKGTAPTTL------KEPAPT-TPKKPAPKELA-PTTTKGPTSTTSDKPAPTTPKE 691 Query: 750 SSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGL 809 ++ P + +P + P P + S V PT + EP + + P Sbjct: 692 TAPTTPKEPAPTTPKKPAPTTPETPPPTTSE---VSTPTTTK-------EPTTIHKSPD- 740 Query: 810 PAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLR 869 + P SA+PT + L + E G P AA + + + + Sbjct: 741 ESTPELSAEPTPKALENSPK----EPGVPTTKTPAAT--------------KPEMTTTAK 782 Query: 870 DHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTE 911 D + + + + TP + T PK+ KE + TTE Sbjct: 783 DKTTERDLRT--------TPETTTAAPKMTKETATTTEKTTE 816 Score = 60.8 bits (146), Expect = 7e-09 Identities = 93/427 (21%), Positives = 137/427 (32%), Gaps = 53/427 (12%) Query: 596 EGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKA 655 +G + + + K AK+L P S L T GPA+ P P P + Sbjct: 165 DGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKE- 223 Query: 656 TLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAG 715 P T TP S PTTP + PA +T + PTT + PA Sbjct: 224 ------PASTTPKEPTPTTIKSAPTTPKE----PA-PTTTKSAPTTPKEPAPTTTKEPAP 272 Query: 716 Q-PEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCH 774 P++PA P+ P+ PT + P K +P + P P Sbjct: 273 TTPKEPAPTTTKEPA-------PTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP 325 Query: 775 QSSLSREVAVVMPTLARGGAAGPGEPVEV--KEPPGLPAKPPASAQPTDELLRHPVTGEV 832 + +E A PT P EP K+P K PA P + P T + Sbjct: 326 TPTTPKEPA---PTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPA---PTTTKE 379 Query: 833 VERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNS- 891 +P + A A S P + ++ S + P + Sbjct: 380 PSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTP 439 Query: 892 --------FTVVPKLPKE-----AEKDSPLTTEIPNKWGPRLGRDAEGTELS----RRHN 934 P PKE +K +P T + P P+ +L+ + Sbjct: 440 KKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLA 499 Query: 935 WTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSN 994 T PE AP E +AP+ + P +P +P +E P P Sbjct: 500 PTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE-------PAPTTPK 552 Query: 995 DPEPPAP 1001 +P P P Sbjct: 553 EPAPTTP 559 Score = 41.2 bits (95), Expect = 0.006 Identities = 96/465 (20%), Positives = 146/465 (31%), Gaps = 90/465 (19%) Query: 591 PKPRL--EGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPE 648 PKP + E G +NG D K++ P STT S PK I P+ Sbjct: 80 PKPPVVDEAGSGLDNG--DFKVTTP------DTSTTQHNKVSTSPKITTAKPINPR---- 127 Query: 649 PAIPPKATLWPATPPKATLGPATPLKA-------TSGPTTPLKATSGPAIASTATTLPTT 701 P+ PP + T L T TT K TS T + T Sbjct: 128 ----------PSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQ 177 Query: 702 TSQLMAEKDSGPAGQ----------------------------PEKPASQEVSTPSQARG 733 + + + KD P + P++PAS P+ Sbjct: 178 SIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTI 237 Query: 734 EGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGG 793 + +P+ +S+ P + +P + P P + ++E A PT + Sbjct: 238 KSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPA---PTTTKSA 294 Query: 794 AAGPGEPVEV---KEPPGLPAKP----PASAQPTDELLRHPVTGEVVERGSPMALLLAAR 846 P EP K P P +P P PT P T E A + Sbjct: 295 PTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPK 354 Query: 847 QRA-QKGRSVGAALGRSSLPGSLRDHS-------HQAEASSDSIFHSQGTPNSFTVVPKL 898 + A + + P + ++ S S + P + P Sbjct: 355 KPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTT 414 Query: 899 PKEAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGH 958 PKE SP TT+ P P+ ++ T P+ AP + AP+ + Sbjct: 415 PKE---PSPTTTKEPAPTTPK----EPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 467 Query: 959 PLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPE--FSNDPEPPAP 1001 P +P +P +E ++ P PE PE PAP Sbjct: 468 PTTPKEPAPTTP----KETAPTTPKKLTPTTPEKLAPTTPEKPAP 508 >gi|189181722 proteoglycan 4 isoform C [Homo sapiens] Length = 1311 Score = 119 bits (299), Expect = 1e-26 Identities = 195/819 (23%), Positives = 282/819 (34%), Gaps = 126/819 (15%) Query: 21 TTPSTSLYATNPPWIFTQEAPEEGTG-GFDGIYYGDNRFNTVSESGTATLKARPRVRPLL 79 T+ TSL + T+E DG + T S T+ P + L Sbjct: 177 TSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLA 236 Query: 80 TFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLRLYSSVGDLRPGQYGQDLLI 139 P G A+ TP P KE T+ + S+ Sbjct: 237 KPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSA--------------- 281 Query: 140 PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPP-----PPVL 194 P P PAP + P P+P +T P P EP P + P P P Sbjct: 282 PTTPKEPAPTTTKSAPTTPKE---PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTT 338 Query: 195 EALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASP-HTVGTRLFPPG 253 P T P+ TP + P P P P P PAP +P T P Sbjct: 339 PKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPA 398 Query: 254 GVTKWKSDVALNGRQAEATRASP-PRSPAEPKGSALGPNP----EPHLTFPRSFKVPP-- 306 T + A T P P +P EP + P EP T +S P Sbjct: 399 PTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE 458 Query: 307 PTPVRTS----SIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDC 362 P+P T + P + A P+K T K P+ P P ++ P+ Sbjct: 459 PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA--PTTPKEPAPTTTKKPAPTTPKEPA 516 Query: 363 PGELKATAPASPRLGQSQSQADERAGTPP--PAPPLP----PPAPPLPPPAPPLPPAAPP 416 P K TAP +P+ + + ++ A T P PAP P P P P P P P AP Sbjct: 517 PTTPKETAPTTPK-KLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEP-APT 574 Query: 417 LPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTA-----SSAPVDWRDPSQMEKLR 471 P A P TPK +P +P P +P+ TA +AP ++P+ + Sbjct: 575 TPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKK 634 Query: 472 ---NELAAYLCGSRREDRFLSHRPGPT----VAPQSKEGKKGPRLPEK----------ET 514 ELA ++ +P PT AP + + + P P++ T Sbjct: 635 PAPKELAP--TTTKEPTSTTCDKPAPTTPKGTAPTTPK-EPAPTTPKEPAPTTPKGTAPT 691 Query: 515 LLSLPAKDTPPGVPEKSL------GGSSLTETEAAPSL---TLPSVDYIP---------- 555 L PA TP K L G +S T + AP+ T P+ P Sbjct: 692 TLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAP 751 Query: 556 --QDSPTPSVRQIRNELEARLSSAAEK---EAKPSIGSLPPKPRLEGGRICENGADDDK- 609 ++P P+ ++ + + K E+ P + + P LE E G K Sbjct: 752 TTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSP-KEPGVPTTKT 810 Query: 610 --LSKPVAKNLPPQST------TLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPAT 661 +KP T T TT+ PK A + T E I T +T Sbjct: 811 PAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTST 870 Query: 662 PPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPA 721 + T TP K T+ TT T P + +T T+ TT E+ + P ++ Sbjct: 871 TTQDT----TPFKITTLKTT----TLAPKVTTTKKTITTTEIMNKPEETAKP---KDRAT 919 Query: 722 SQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSP 760 + + +TP + P++A + PT + PKT P Sbjct: 920 NSKATTPKPQK----PTKAPKKPTSTKK------PKTMP 948 Score = 119 bits (298), Expect = 2e-26 Identities = 176/711 (24%), Positives = 246/711 (34%), Gaps = 121/711 (17%) Query: 140 PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPP------PSMAPPPPPV 193 P P PAP P+ EP +P P+T P P EP P P+ P P Sbjct: 352 PTTPKEPAPTTPK---EPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPT 408 Query: 194 LEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAP-----APPAPASPHTVGTR 248 P T PS TP + PAP AP PAP AP P P T+ Sbjct: 409 TPKEPAPTTTKEPSPTTPKE---PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTK 465 Query: 249 LFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPT 308 P T + + A T P +P PK A +P T P+ + P T Sbjct: 466 --EPAPTTPKEPAPTTPKKPAPTTPKEP--APTTPKEPAPTTTKKPAPTTPK--EPAPTT 519 Query: 309 PVRTS-SIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPD-RAPEPDCPGEL 366 P T+ + P + P K T + P+ P P + P + P PE P Sbjct: 520 PKETAPTTPKKLTPTTPEKLAPTTPEKPA--PTTPE-ELAPTTPEEPTPTTPEEPAPTTP 576 Query: 367 KATAPASPRLGQSQSQADERAGTPP-PAPPLPPPAPPLPP----------PAPPLPPAAP 415 KA AP +P+ + + TP PAP P P P PAP P Sbjct: 577 KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPA 636 Query: 416 PLPCAQKAAHPPAGFT------KTPKSSSPALKPKPNP-----PSPENTASSAPVDWRDP 464 P A P T TPK ++P +P P P+P +AP ++P Sbjct: 637 PKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEP 696 Query: 465 SQMEKLR---NELAAYLCGSRREDRFLSHRPGPTV----APQSKEGKKGPRLPEKETLLS 517 + + ELA ++ S +P PT AP + + + P P+K Sbjct: 697 APTTPKKPAPKELAPTT--TKGPTSTTSDKPAPTTPKETAPTTPK-EPAPTTPKK----- 748 Query: 518 LPAKDTPPGVPEKSLGGSSLTET-----------EAAPSL----TLPSVDYIPQDSPTPS 562 PA TP P + S+ T T E+ P L T +++ P++ P+ Sbjct: 749 -PAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPT 807 Query: 563 VRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKL--SKPVAKNLPP 620 + ++A +K + + + P E +K SK A Sbjct: 808 TKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQV 867 Query: 621 QSTTLLPTTSLQPKAMLGPAIPPKAT--------------PEPAIPPK--ATLWPATPPK 664 STT TT + + + PK T PE PK AT AT PK Sbjct: 868 TSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPK 927 Query: 665 ATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQE 724 P P KA PT+ K + P + TT PT + P + + Q Sbjct: 928 ----PQKPTKAPKKPTSTKKPKTMPRVRKPKTT-PTPRKMTSTMPELNPTSRIAEAMLQT 982 Query: 725 VSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGG--GEVP-CLYKPH 772 + P+Q T ++ P GG GE P L +PH Sbjct: 983 TTRPNQ--------------TPNSKLVEVNPKSEDAGGAEGETPHMLLRPH 1019 Score = 114 bits (285), Expect = 6e-25 Identities = 188/762 (24%), Positives = 261/762 (34%), Gaps = 156/762 (20%) Query: 164 PSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAF 223 P+P + P L P P P P P T + TP + PAP Sbjct: 238 PTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKE---PAPTTTK 294 Query: 224 LAPPPPPVPAPAP---PAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSP 280 AP P PAP PAP +P T KS A T P +P Sbjct: 295 SAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKP--AP 352 Query: 281 AEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPL 340 PK A EP T P+ + P T + P + A AP+K T K P+ Sbjct: 353 TTPKEPAPTTPKEPTPTTPK--EPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA---- 406 Query: 341 PPSFHIRPASQVYPDRAPEPDCPGE-LKATAPASPRLGQSQSQADERAGTPPPAPPLPP- 398 P+ PA + P P P E T ++P + + ++ P P P Sbjct: 407 -PTTPKEPAPTT--TKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTT 463 Query: 399 ---PAPPLPP-PAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTA 454 PAP P PAP P P P K P TPK +P KP P +P+ A Sbjct: 464 TKEPAPTTPKEPAPTTPKK--PAPTTPKEPAPT-----TPKEPAPTTTKKPAPTTPKEPA 516 Query: 455 SSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKET 514 + P + P+ +KL P + E K P PEK Sbjct: 517 PTTPKETA-PTTPKKL--------------------------TPTTPE-KLAPTTPEK-- 546 Query: 515 LLSLPAKDTP----PGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNEL 570 PA TP P PE+ + T E AP+ + P++ P P+ Sbjct: 547 ----PAPTTPEELAPTTPEEP---TPTTPEEPAPTTPKAAAPNTPKE-PAPTT------- 591 Query: 571 EARLSSAAEKEAKPSIGSLP-PKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTT 629 KE P+ P P E G L +P PTT Sbjct: 592 --------PKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPA------------PTT 631 Query: 630 SLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGP 689 PK + P T EP P TP K T P TP + PTTP + P Sbjct: 632 ---PKKPAPKELAPTTTKEPTSTTCDKPAPTTP-KGT-APTTPKEPA--PTTPKE----P 680 Query: 690 AIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGAR 749 A + T PTT K+ P P+KPA +E++ P+ +G S + PT Sbjct: 681 APTTPKGTAPTTL------KEPAPT-TPKKPAPKELA-PTTTKGPTSTTSDKPAPTTPKE 732 Query: 750 SSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGL 809 ++ P + +P + P P + S V PT + EP + + P Sbjct: 733 TAPTTPKEPAPTTPKKPAPTTPETPPPTTSE---VSTPTTTK-------EPTTIHKSPD- 781 Query: 810 PAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLR 869 + P SA+PT + L + E G P AA + + + + Sbjct: 782 ESTPELSAEPTPKALENSPK----EPGVPTTKTPAAT--------------KPEMTTTAK 823 Query: 870 DHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTE 911 D + + + + TP + T PK+ KE + TTE Sbjct: 824 DKTTERDLRT--------TPETTTAAPKMTKETATTTEKTTE 857 Score = 60.8 bits (146), Expect = 7e-09 Identities = 93/427 (21%), Positives = 137/427 (32%), Gaps = 53/427 (12%) Query: 596 EGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKA 655 +G + + + K AK+L P S L T GPA+ P P P + Sbjct: 206 DGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKE- 264 Query: 656 TLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAG 715 P T TP S PTTP + PA +T + PTT + PA Sbjct: 265 ------PASTTPKEPTPTTIKSAPTTPKE----PA-PTTTKSAPTTPKEPAPTTTKEPAP 313 Query: 716 Q-PEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCH 774 P++PA P+ P+ PT + P K +P + P P Sbjct: 314 TTPKEPAPTTTKEPA-------PTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP 366 Query: 775 QSSLSREVAVVMPTLARGGAAGPGEPVEV--KEPPGLPAKPPASAQPTDELLRHPVTGEV 832 + +E A PT P EP K+P K PA P + P T + Sbjct: 367 TPTTPKEPA---PTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPA---PTTTKE 420 Query: 833 VERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNS- 891 +P + A A S P + ++ S + P + Sbjct: 421 PSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTP 480 Query: 892 --------FTVVPKLPKE-----AEKDSPLTTEIPNKWGPRLGRDAEGTELS----RRHN 934 P PKE +K +P T + P P+ +L+ + Sbjct: 481 KKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLA 540 Query: 935 WTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSN 994 T PE AP E +AP+ + P +P +P +E P P Sbjct: 541 PTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE-------PAPTTPK 593 Query: 995 DPEPPAP 1001 +P P P Sbjct: 594 EPAPTTP 600 Score = 41.2 bits (95), Expect = 0.006 Identities = 96/465 (20%), Positives = 146/465 (31%), Gaps = 90/465 (19%) Query: 591 PKPRL--EGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPE 648 PKP + E G +NG D K++ P STT S PK I P+ Sbjct: 121 PKPPVVDEAGSGLDNG--DFKVTTP------DTSTTQHNKVSTSPKITTAKPINPR---- 168 Query: 649 PAIPPKATLWPATPPKATLGPATPLKA-------TSGPTTPLKATSGPAIASTATTLPTT 701 P+ PP + T L T TT K TS T + T Sbjct: 169 ----------PSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQ 218 Query: 702 TSQLMAEKDSGPAGQ----------------------------PEKPASQEVSTPSQARG 733 + + + KD P + P++PAS P+ Sbjct: 219 SIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTI 278 Query: 734 EGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGG 793 + +P+ +S+ P + +P + P P + ++E A PT + Sbjct: 279 KSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPA---PTTTKSA 335 Query: 794 AAGPGEPVEV---KEPPGLPAKP----PASAQPTDELLRHPVTGEVVERGSPMALLLAAR 846 P EP K P P +P P PT P T E A + Sbjct: 336 PTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPK 395 Query: 847 QRA-QKGRSVGAALGRSSLPGSLRDHS-------HQAEASSDSIFHSQGTPNSFTVVPKL 898 + A + + P + ++ S S + P + P Sbjct: 396 KPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTT 455 Query: 899 PKEAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGH 958 PKE SP TT+ P P+ ++ T P+ AP + AP+ + Sbjct: 456 PKE---PSPTTTKEPAPTTPK----EPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 508 Query: 959 PLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPE--FSNDPEPPAP 1001 P +P +P +E ++ P PE PE PAP Sbjct: 509 PTTPKEPAPTTP----KETAPTTPKKLTPTTPEKLAPTTPEKPAP 549 >gi|189181720 proteoglycan 4 isoform B [Homo sapiens] Length = 1363 Score = 119 bits (299), Expect = 1e-26 Identities = 195/819 (23%), Positives = 282/819 (34%), Gaps = 126/819 (15%) Query: 21 TTPSTSLYATNPPWIFTQEAPEEGTG-GFDGIYYGDNRFNTVSESGTATLKARPRVRPLL 79 T+ TSL + T+E DG + T S T+ P + L Sbjct: 229 TSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLA 288 Query: 80 TFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLRLYSSVGDLRPGQYGQDLLI 139 P G A+ TP P KE T+ + S+ Sbjct: 289 KPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSA--------------- 333 Query: 140 PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPP-----PPVL 194 P P PAP + P P+P +T P P EP P + P P P Sbjct: 334 PTTPKEPAPTTTKSAPTTPKE---PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTT 390 Query: 195 EALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASP-HTVGTRLFPPG 253 P T P+ TP + P P P P P PAP +P T P Sbjct: 391 PKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPA 450 Query: 254 GVTKWKSDVALNGRQAEATRASP-PRSPAEPKGSALGPNP----EPHLTFPRSFKVPP-- 306 T + A T P P +P EP + P EP T +S P Sbjct: 451 PTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE 510 Query: 307 PTPVRTS----SIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDC 362 P+P T + P + A P+K T K P+ P P ++ P+ Sbjct: 511 PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA--PTTPKEPAPTTTKKPAPTTPKEPA 568 Query: 363 PGELKATAPASPRLGQSQSQADERAGTPP--PAPPLP----PPAPPLPPPAPPLPPAAPP 416 P K TAP +P+ + + ++ A T P PAP P P P P P P P AP Sbjct: 569 PTTPKETAPTTPK-KLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEP-APT 626 Query: 417 LPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTA-----SSAPVDWRDPSQMEKLR 471 P A P TPK +P +P P +P+ TA +AP ++P+ + Sbjct: 627 TPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKK 686 Query: 472 ---NELAAYLCGSRREDRFLSHRPGPT----VAPQSKEGKKGPRLPEK----------ET 514 ELA ++ +P PT AP + + + P P++ T Sbjct: 687 PAPKELAP--TTTKEPTSTTCDKPAPTTPKGTAPTTPK-EPAPTTPKEPAPTTPKGTAPT 743 Query: 515 LLSLPAKDTPPGVPEKSL------GGSSLTETEAAPSL---TLPSVDYIP---------- 555 L PA TP K L G +S T + AP+ T P+ P Sbjct: 744 TLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAP 803 Query: 556 --QDSPTPSVRQIRNELEARLSSAAEK---EAKPSIGSLPPKPRLEGGRICENGADDDK- 609 ++P P+ ++ + + K E+ P + + P LE E G K Sbjct: 804 TTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSP-KEPGVPTTKT 862 Query: 610 --LSKPVAKNLPPQST------TLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPAT 661 +KP T T TT+ PK A + T E I T +T Sbjct: 863 PAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTST 922 Query: 662 PPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPA 721 + T TP K T+ TT T P + +T T+ TT E+ + P ++ Sbjct: 923 TTQDT----TPFKITTLKTT----TLAPKVTTTKKTITTTEIMNKPEETAKP---KDRAT 971 Query: 722 SQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSP 760 + + +TP + P++A + PT + PKT P Sbjct: 972 NSKATTPKPQK----PTKAPKKPTSTKK------PKTMP 1000 Score = 119 bits (298), Expect = 2e-26 Identities = 176/711 (24%), Positives = 246/711 (34%), Gaps = 121/711 (17%) Query: 140 PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPP------PSMAPPPPPV 193 P P PAP P+ EP +P P+T P P EP P P+ P P Sbjct: 404 PTTPKEPAPTTPK---EPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPT 460 Query: 194 LEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAP-----APPAPASPHTVGTR 248 P T PS TP + PAP AP PAP AP P P T+ Sbjct: 461 TPKEPAPTTTKEPSPTTPKE---PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTK 517 Query: 249 LFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPT 308 P T + + A T P +P PK A +P T P+ + P T Sbjct: 518 --EPAPTTPKEPAPTTPKKPAPTTPKEP--APTTPKEPAPTTTKKPAPTTPK--EPAPTT 571 Query: 309 PVRTS-SIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPD-RAPEPDCPGEL 366 P T+ + P + P K T + P+ P P + P + P PE P Sbjct: 572 PKETAPTTPKKLTPTTPEKLAPTTPEKPA--PTTPE-ELAPTTPEEPTPTTPEEPAPTTP 628 Query: 367 KATAPASPRLGQSQSQADERAGTPP-PAPPLPPPAPPLPP----------PAPPLPPAAP 415 KA AP +P+ + + TP PAP P P P PAP P Sbjct: 629 KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPA 688 Query: 416 PLPCAQKAAHPPAGFT------KTPKSSSPALKPKPNP-----PSPENTASSAPVDWRDP 464 P A P T TPK ++P +P P P+P +AP ++P Sbjct: 689 PKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEP 748 Query: 465 SQMEKLR---NELAAYLCGSRREDRFLSHRPGPTV----APQSKEGKKGPRLPEKETLLS 517 + + ELA ++ S +P PT AP + + + P P+K Sbjct: 749 APTTPKKPAPKELAPTT--TKGPTSTTSDKPAPTTPKETAPTTPK-EPAPTTPKK----- 800 Query: 518 LPAKDTPPGVPEKSLGGSSLTET-----------EAAPSL----TLPSVDYIPQDSPTPS 562 PA TP P + S+ T T E+ P L T +++ P++ P+ Sbjct: 801 -PAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPT 859 Query: 563 VRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKL--SKPVAKNLPP 620 + ++A +K + + + P E +K SK A Sbjct: 860 TKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQV 919 Query: 621 QSTTLLPTTSLQPKAMLGPAIPPKAT--------------PEPAIPPK--ATLWPATPPK 664 STT TT + + + PK T PE PK AT AT PK Sbjct: 920 TSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPK 979 Query: 665 ATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQE 724 P P KA PT+ K + P + TT PT + P + + Q Sbjct: 980 ----PQKPTKAPKKPTSTKKPKTMPRVRKPKTT-PTPRKMTSTMPELNPTSRIAEAMLQT 1034 Query: 725 VSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGG--GEVP-CLYKPH 772 + P+Q T ++ P GG GE P L +PH Sbjct: 1035 TTRPNQ--------------TPNSKLVEVNPKSEDAGGAEGETPHMLLRPH 1071 Score = 114 bits (285), Expect = 6e-25 Identities = 188/762 (24%), Positives = 261/762 (34%), Gaps = 156/762 (20%) Query: 164 PSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAF 223 P+P + P L P P P P P T + TP + PAP Sbjct: 290 PTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKE---PAPTTTK 346 Query: 224 LAPPPPPVPAPAP---PAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSP 280 AP P PAP PAP +P T KS A T P +P Sbjct: 347 SAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKP--AP 404 Query: 281 AEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPL 340 PK A EP T P+ + P T + P + A AP+K T K P+ Sbjct: 405 TTPKEPAPTTPKEPTPTTPK--EPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA---- 458 Query: 341 PPSFHIRPASQVYPDRAPEPDCPGE-LKATAPASPRLGQSQSQADERAGTPPPAPPLPP- 398 P+ PA + P P P E T ++P + + ++ P P P Sbjct: 459 -PTTPKEPAPTT--TKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTT 515 Query: 399 ---PAPPLPP-PAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTA 454 PAP P PAP P P P K P TPK +P KP P +P+ A Sbjct: 516 TKEPAPTTPKEPAPTTPKK--PAPTTPKEPAPT-----TPKEPAPTTTKKPAPTTPKEPA 568 Query: 455 SSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKET 514 + P + P+ +KL P + E K P PEK Sbjct: 569 PTTPKETA-PTTPKKL--------------------------TPTTPE-KLAPTTPEK-- 598 Query: 515 LLSLPAKDTP----PGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNEL 570 PA TP P PE+ + T E AP+ + P++ P P+ Sbjct: 599 ----PAPTTPEELAPTTPEEP---TPTTPEEPAPTTPKAAAPNTPKE-PAPTT------- 643 Query: 571 EARLSSAAEKEAKPSIGSLP-PKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTT 629 KE P+ P P E G L +P PTT Sbjct: 644 --------PKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPA------------PTT 683 Query: 630 SLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGP 689 PK + P T EP P TP K T P TP + PTTP + P Sbjct: 684 ---PKKPAPKELAPTTTKEPTSTTCDKPAPTTP-KGT-APTTPKEPA--PTTPKE----P 732 Query: 690 AIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGAR 749 A + T PTT K+ P P+KPA +E++ P+ +G S + PT Sbjct: 733 APTTPKGTAPTTL------KEPAPT-TPKKPAPKELA-PTTTKGPTSTTSDKPAPTTPKE 784 Query: 750 SSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGL 809 ++ P + +P + P P + S V PT + EP + + P Sbjct: 785 TAPTTPKEPAPTTPKKPAPTTPETPPPTTSE---VSTPTTTK-------EPTTIHKSPD- 833 Query: 810 PAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLR 869 + P SA+PT + L + E G P AA + + + + Sbjct: 834 ESTPELSAEPTPKALENSPK----EPGVPTTKTPAAT--------------KPEMTTTAK 875 Query: 870 DHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTE 911 D + + + + TP + T PK+ KE + TTE Sbjct: 876 DKTTERDLRT--------TPETTTAAPKMTKETATTTEKTTE 909 Score = 74.3 bits (181), Expect = 6e-13 Identities = 130/610 (21%), Positives = 200/610 (32%), Gaps = 60/610 (9%) Query: 415 PPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNEL 474 P P + K A PP+G ++T KS++ K P PP+ + T + E Sbjct: 69 PTSPPSSKKAPPPSGASQTIKSTT---KRSPKPPNKKKTKKVIESEEITEEHSVSENQES 125 Query: 475 AAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLG- 533 ++ S + A + KK K+ PP V E G Sbjct: 126 SSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGL 185 Query: 534 --------GSSLTETEAAPSLTLPSVDYIPQDSPTPSV---RQIRNELEARLSSAAEKEA 582 + T+ T P + +P PS+ E ++ E Sbjct: 186 DNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVET 245 Query: 583 KPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIP 642 K + + + +G + + + K AK+L P S L T GPA+ Sbjct: 246 KETT-TTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALT 304 Query: 643 PKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTT 702 P P P + P T TP S PTTP + PA +T + PTT Sbjct: 305 TPKEPTPTTPKE-------PASTTPKEPTPTTIKSAPTTPKE----PA-PTTTKSAPTTP 352 Query: 703 SQLMAEKDSGPA-GQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPG 761 + PA P++PA P +P+ PT + P K +P Sbjct: 353 KEPAPTTTKEPAPTTPKEPAPTTTKEP-------APTTTKSAPTTPKEPAPTTPKKPAPT 405 Query: 762 GGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEV--KEPPGLPAKPPASAQP 819 + P P + +E A PT P EP K+P K PA P Sbjct: 406 TPKEPAPTTPKEPTPTTPKEPA---PTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTP 462 Query: 820 TDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASS 879 + P T + +P + A A S P + ++ S Sbjct: 463 KEPA---PTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEP 519 Query: 880 DSIFHSQGTPNS-FTVVPKLPKE-----AEKDSPLTTEIPNKWGPRLGRDAEGTELSRRH 933 + P + P PKE ++ +P TT+ P P+ E + Sbjct: 520 APTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAP-- 577 Query: 934 NWTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFS 993 T P+ P E++AP+ + P +P +P EE E P P+ + Sbjct: 578 --TTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTP----EEPTPTTPEEPAPTTPKAA 631 Query: 994 --NDPEPPAP 1001 N P+ PAP Sbjct: 632 APNTPKEPAP 641 >gi|67190163 proteoglycan 4 isoform A [Homo sapiens] Length = 1404 Score = 119 bits (299), Expect = 1e-26 Identities = 195/819 (23%), Positives = 282/819 (34%), Gaps = 126/819 (15%) Query: 21 TTPSTSLYATNPPWIFTQEAPEEGTG-GFDGIYYGDNRFNTVSESGTATLKARPRVRPLL 79 T+ TSL + T+E DG + T S T+ P + L Sbjct: 270 TSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLA 329 Query: 80 TFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLRLYSSVGDLRPGQYGQDLLI 139 P G A+ TP P KE T+ + S+ Sbjct: 330 KPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSA--------------- 374 Query: 140 PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPP-----PPVL 194 P P PAP + P P+P +T P P EP P + P P P Sbjct: 375 PTTPKEPAPTTTKSAPTTPKE---PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTT 431 Query: 195 EALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASP-HTVGTRLFPPG 253 P T P+ TP + P P P P P PAP +P T P Sbjct: 432 PKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPA 491 Query: 254 GVTKWKSDVALNGRQAEATRASP-PRSPAEPKGSALGPNP----EPHLTFPRSFKVPP-- 306 T + A T P P +P EP + P EP T +S P Sbjct: 492 PTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE 551 Query: 307 PTPVRTS----SIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDC 362 P+P T + P + A P+K T K P+ P P ++ P+ Sbjct: 552 PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA--PTTPKEPAPTTTKKPAPTTPKEPA 609 Query: 363 PGELKATAPASPRLGQSQSQADERAGTPP--PAPPLP----PPAPPLPPPAPPLPPAAPP 416 P K TAP +P+ + + ++ A T P PAP P P P P P P P AP Sbjct: 610 PTTPKETAPTTPK-KLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEP-APT 667 Query: 417 LPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTA-----SSAPVDWRDPSQMEKLR 471 P A P TPK +P +P P +P+ TA +AP ++P+ + Sbjct: 668 TPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKK 727 Query: 472 ---NELAAYLCGSRREDRFLSHRPGPT----VAPQSKEGKKGPRLPEK----------ET 514 ELA ++ +P PT AP + + + P P++ T Sbjct: 728 PAPKELAP--TTTKEPTSTTCDKPAPTTPKGTAPTTPK-EPAPTTPKEPAPTTPKGTAPT 784 Query: 515 LLSLPAKDTPPGVPEKSL------GGSSLTETEAAPSL---TLPSVDYIP---------- 555 L PA TP K L G +S T + AP+ T P+ P Sbjct: 785 TLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAP 844 Query: 556 --QDSPTPSVRQIRNELEARLSSAAEK---EAKPSIGSLPPKPRLEGGRICENGADDDK- 609 ++P P+ ++ + + K E+ P + + P LE E G K Sbjct: 845 TTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSP-KEPGVPTTKT 903 Query: 610 --LSKPVAKNLPPQST------TLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPAT 661 +KP T T TT+ PK A + T E I T +T Sbjct: 904 PAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTST 963 Query: 662 PPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPA 721 + T TP K T+ TT T P + +T T+ TT E+ + P ++ Sbjct: 964 TTQDT----TPFKITTLKTT----TLAPKVTTTKKTITTTEIMNKPEETAKP---KDRAT 1012 Query: 722 SQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSP 760 + + +TP + P++A + PT + PKT P Sbjct: 1013 NSKATTPKPQK----PTKAPKKPTSTKK------PKTMP 1041 Score = 119 bits (298), Expect = 2e-26 Identities = 176/711 (24%), Positives = 246/711 (34%), Gaps = 121/711 (17%) Query: 140 PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPP------PSMAPPPPPV 193 P P PAP P+ EP +P P+T P P EP P P+ P P Sbjct: 445 PTTPKEPAPTTPK---EPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPT 501 Query: 194 LEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAP-----APPAPASPHTVGTR 248 P T PS TP + PAP AP PAP AP P P T+ Sbjct: 502 TPKEPAPTTTKEPSPTTPKE---PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTK 558 Query: 249 LFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPT 308 P T + + A T P +P PK A +P T P+ + P T Sbjct: 559 --EPAPTTPKEPAPTTPKKPAPTTPKEP--APTTPKEPAPTTTKKPAPTTPK--EPAPTT 612 Query: 309 PVRTS-SIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPD-RAPEPDCPGEL 366 P T+ + P + P K T + P+ P P + P + P PE P Sbjct: 613 PKETAPTTPKKLTPTTPEKLAPTTPEKPA--PTTPE-ELAPTTPEEPTPTTPEEPAPTTP 669 Query: 367 KATAPASPRLGQSQSQADERAGTPP-PAPPLPPPAPPLPP----------PAPPLPPAAP 415 KA AP +P+ + + TP PAP P P P PAP P Sbjct: 670 KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPA 729 Query: 416 PLPCAQKAAHPPAGFT------KTPKSSSPALKPKPNP-----PSPENTASSAPVDWRDP 464 P A P T TPK ++P +P P P+P +AP ++P Sbjct: 730 PKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEP 789 Query: 465 SQMEKLR---NELAAYLCGSRREDRFLSHRPGPTV----APQSKEGKKGPRLPEKETLLS 517 + + ELA ++ S +P PT AP + + + P P+K Sbjct: 790 APTTPKKPAPKELAPTT--TKGPTSTTSDKPAPTTPKETAPTTPK-EPAPTTPKK----- 841 Query: 518 LPAKDTPPGVPEKSLGGSSLTET-----------EAAPSL----TLPSVDYIPQDSPTPS 562 PA TP P + S+ T T E+ P L T +++ P++ P+ Sbjct: 842 -PAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPT 900 Query: 563 VRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKL--SKPVAKNLPP 620 + ++A +K + + + P E +K SK A Sbjct: 901 TKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQV 960 Query: 621 QSTTLLPTTSLQPKAMLGPAIPPKAT--------------PEPAIPPK--ATLWPATPPK 664 STT TT + + + PK T PE PK AT AT PK Sbjct: 961 TSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPK 1020 Query: 665 ATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQE 724 P P KA PT+ K + P + TT PT + P + + Q Sbjct: 1021 ----PQKPTKAPKKPTSTKKPKTMPRVRKPKTT-PTPRKMTSTMPELNPTSRIAEAMLQT 1075 Query: 725 VSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGG--GEVP-CLYKPH 772 + P+Q T ++ P GG GE P L +PH Sbjct: 1076 TTRPNQ--------------TPNSKLVEVNPKSEDAGGAEGETPHMLLRPH 1112 Score = 114 bits (285), Expect = 6e-25 Identities = 188/762 (24%), Positives = 261/762 (34%), Gaps = 156/762 (20%) Query: 164 PSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAF 223 P+P + P L P P P P P T + TP + PAP Sbjct: 331 PTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKE---PAPTTTK 387 Query: 224 LAPPPPPVPAPAP---PAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSP 280 AP P PAP PAP +P T KS A T P +P Sbjct: 388 SAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKP--AP 445 Query: 281 AEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPL 340 PK A EP T P+ + P T + P + A AP+K T K P+ Sbjct: 446 TTPKEPAPTTPKEPTPTTPK--EPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA---- 499 Query: 341 PPSFHIRPASQVYPDRAPEPDCPGE-LKATAPASPRLGQSQSQADERAGTPPPAPPLPP- 398 P+ PA + P P P E T ++P + + ++ P P P Sbjct: 500 -PTTPKEPAPTT--TKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTT 556 Query: 399 ---PAPPLPP-PAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTA 454 PAP P PAP P P P K P TPK +P KP P +P+ A Sbjct: 557 TKEPAPTTPKEPAPTTPKK--PAPTTPKEPAPT-----TPKEPAPTTTKKPAPTTPKEPA 609 Query: 455 SSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKET 514 + P + P+ +KL P + E K P PEK Sbjct: 610 PTTPKETA-PTTPKKL--------------------------TPTTPE-KLAPTTPEK-- 639 Query: 515 LLSLPAKDTP----PGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNEL 570 PA TP P PE+ + T E AP+ + P++ P P+ Sbjct: 640 ----PAPTTPEELAPTTPEEP---TPTTPEEPAPTTPKAAAPNTPKE-PAPTT------- 684 Query: 571 EARLSSAAEKEAKPSIGSLP-PKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTT 629 KE P+ P P E G L +P PTT Sbjct: 685 --------PKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPA------------PTT 724 Query: 630 SLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGP 689 PK + P T EP P TP K T P TP + PTTP + P Sbjct: 725 ---PKKPAPKELAPTTTKEPTSTTCDKPAPTTP-KGT-APTTPKEPA--PTTPKE----P 773 Query: 690 AIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGAR 749 A + T PTT K+ P P+KPA +E++ P+ +G S + PT Sbjct: 774 APTTPKGTAPTTL------KEPAPT-TPKKPAPKELA-PTTTKGPTSTTSDKPAPTTPKE 825 Query: 750 SSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGL 809 ++ P + +P + P P + S V PT + EP + + P Sbjct: 826 TAPTTPKEPAPTTPKKPAPTTPETPPPTTSE---VSTPTTTK-------EPTTIHKSPD- 874 Query: 810 PAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLR 869 + P SA+PT + L + E G P AA + + + + Sbjct: 875 ESTPELSAEPTPKALENSPK----EPGVPTTKTPAAT--------------KPEMTTTAK 916 Query: 870 DHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTE 911 D + + + + TP + T PK+ KE + TTE Sbjct: 917 DKTTERDLRT--------TPETTTAAPKMTKETATTTEKTTE 950 Score = 74.3 bits (181), Expect = 6e-13 Identities = 130/610 (21%), Positives = 200/610 (32%), Gaps = 60/610 (9%) Query: 415 PPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNEL 474 P P + K A PP+G ++T KS++ K P PP+ + T + E Sbjct: 110 PTSPPSSKKAPPPSGASQTIKSTT---KRSPKPPNKKKTKKVIESEEITEEHSVSENQES 166 Query: 475 AAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLG- 533 ++ S + A + KK K+ PP V E G Sbjct: 167 SSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGL 226 Query: 534 --------GSSLTETEAAPSLTLPSVDYIPQDSPTPSV---RQIRNELEARLSSAAEKEA 582 + T+ T P + +P PS+ E ++ E Sbjct: 227 DNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVET 286 Query: 583 KPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIP 642 K + + + +G + + + K AK+L P S L T GPA+ Sbjct: 287 KETT-TTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALT 345 Query: 643 PKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTT 702 P P P + P T TP S PTTP + PA +T + PTT Sbjct: 346 TPKEPTPTTPKE-------PASTTPKEPTPTTIKSAPTTPKE----PA-PTTTKSAPTTP 393 Query: 703 SQLMAEKDSGPA-GQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPG 761 + PA P++PA P +P+ PT + P K +P Sbjct: 394 KEPAPTTTKEPAPTTPKEPAPTTTKEP-------APTTTKSAPTTPKEPAPTTPKKPAPT 446 Query: 762 GGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEV--KEPPGLPAKPPASAQP 819 + P P + +E A PT P EP K+P K PA P Sbjct: 447 TPKEPAPTTPKEPTPTTPKEPA---PTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTP 503 Query: 820 TDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASS 879 + P T + +P + A A S P + ++ S Sbjct: 504 KEPA---PTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEP 560 Query: 880 DSIFHSQGTPNS-FTVVPKLPKE-----AEKDSPLTTEIPNKWGPRLGRDAEGTELSRRH 933 + P + P PKE ++ +P TT+ P P+ E + Sbjct: 561 APTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAP-- 618 Query: 934 NWTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFS 993 T P+ P E++AP+ + P +P +P EE E P P+ + Sbjct: 619 --TTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTP----EEPTPTTPEEPAPTTPKAA 672 Query: 994 --NDPEPPAP 1001 N P+ PAP Sbjct: 673 APNTPKEPAP 682 >gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens] Length = 416 Score = 110 bits (274), Expect = 1e-23 Identities = 110/356 (30%), Positives = 134/356 (37%), Gaps = 42/356 (11%) Query: 130 PGQYGQDLLIPPPPPGPAPGPP-QDISEPPGGSPLPSPPSTAPP---------PPPLLLE 179 P Q G PP PPG GPP Q ++P G P P P PP PPP + Sbjct: 40 PPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQ 99 Query: 180 PPPPP---SMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPP--PPPVPAP 234 PPP S +P PP PP + P P PP P PP P PPP P Sbjct: 100 GPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKP 159 Query: 235 APPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSA-LGPNPE 293 P P + + PPG K + G Q + PP P +P+G G N Sbjct: 160 QGPPPQGDNKSRSSRSPPG---KPQGPPPQGGNQPQG----PPPPPGKPQGPPPQGGNKP 212 Query: 294 PHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKA---PSRLPLPPSFHIRPAS 350 P + PPP S Q A+ P K +G + P P PP P Sbjct: 213 QGPPPPGKPQGPPPQGDNKS----QSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPP 268 Query: 351 QV--YPDRAPEPDCP------GELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPP 402 Q P P P P G K+ + SP G+ Q + G P PP PP P Sbjct: 269 QGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPP-GKPQGPPPQ-GGNQPQGPPPPPGKPQ 326 Query: 403 LPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAP 458 PPP P PP P + PP G +K+ + SP KP+ PP E P Sbjct: 327 GPPPQGGNKPQGPP-PPGKPQGPPPQGGSKSRSARSPPGKPQ-GPPQQEGNNPQGP 380 Score = 90.1 bits (222), Expect = 1e-17 Identities = 92/318 (28%), Positives = 119/318 (37%), Gaps = 30/318 (9%) Query: 152 QDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTP 211 +D+S+ S + P APP + PP P P P PP + P P P Sbjct: 21 EDVSQEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGP-------PPQGGNQPQGPPP 73 Query: 212 PDFIPPAPPLAFLAPP--PPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQA 269 P P PP P PPP P P P + R PPG K + G Q Sbjct: 74 PPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPR-SPPG---KPQGPPPQGGNQP 129 Query: 270 EATRASPPRSPAEPKG-SALGPNPEPHLTFPRSFKVPPP---TPVRTSSIPVQEAQEAPR 325 + PP P +P+G G N P + PPP R+S P + Q P Sbjct: 130 Q----GPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQ-GPP 184 Query: 326 KEEGATKKAPSRLP-----LPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQ 380 + G + P P PP +P P + P G+ K+ + SP G+ Q Sbjct: 185 PQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPP-GKPQ 243 Query: 381 SQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPA 440 + G P PP PP P PPP P PP P + PP G +K+ S SP Sbjct: 244 GPPPQ-GGNQPQGPPPPPGKPQGPPPQGGNKPQGPP-PPGKPQGPPPQGGSKSRSSRSPP 301 Query: 441 LKPKPNPPSPENTASSAP 458 KP+ PP N P Sbjct: 302 GKPQGPPPQGGNQPQGPP 319 Score = 52.0 bits (123), Expect = 3e-06 Identities = 104/450 (23%), Positives = 144/450 (32%), Gaps = 61/450 (13%) Query: 318 QEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLG 377 Q E +EE + A + PP +P P P+ P P G Sbjct: 17 QNLNEDVSQEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPPPPPG 76 Query: 378 QSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSS 437 + Q + P PP P P P P +PP + PP G + Sbjct: 77 KPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPP---GKPQGPPPQGGNQPQGPP 133 Query: 438 SPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRP-GPTV 496 P KP+ PP N P + + N+ R R +P GP Sbjct: 134 PPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNK--------SRSSRSPPGKPQGP-- 183 Query: 497 APQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQ 556 PQ +GP P P K P G P + GG+ + + P P Sbjct: 184 PPQGGNQPQGPPPP--------PGK--PQGPPPQ--GGN---KPQGPPPPGKPQGPPPQG 228 Query: 557 DSPTPSVRQIRNELEARLSSAA-EKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVA 615 D+ + S R + + + + P P P +GG + K P Sbjct: 229 DNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGP-- 286 Query: 616 KNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKA 675 PPQ + ++ P GP PP+ +P PP P PP G P Sbjct: 287 ---PPQGGSKSRSSRSPPGKPQGP--PPQGGNQPQGPPPPPGKPQGPPPQ--GGNKP--- 336 Query: 676 TSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEG 735 GP P K P P S+ + + P G+P+ P QE + P +G Sbjct: 337 -QGPPPPGKPQGPP---------PQGGSKSRSAR--SPPGKPQGPPQQEGNNP-----QG 379 Query: 736 SPSEATRLPTQGARSSAAFP--PKTSPGGG 763 P A P Q A P P P GG Sbjct: 380 PPPPAGGNPQQPQAPPAGQPQGPPRPPQGG 409 Score = 52.0 bits (123), Expect = 3e-06 Identities = 107/462 (23%), Positives = 143/462 (30%), Gaps = 94/462 (20%) Query: 373 SPRLGQSQSQ-ADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFT 431 SP L Q A + G P PP PP P PPP P PP PP G Sbjct: 28 SPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPP---------PPPG-- 76 Query: 432 KTPKSSSPALKPKPNPPSPENTASSAPVDWR---DPSQMEKLRNELAAYLCGSRREDRFL 488 KP+ PP N P + P Q +K R+ + Sbjct: 77 ----------KPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSP------------ 114 Query: 489 SHRPGPTVAPQSKEGK--KGPRLPEKETLLSLPA---KDTPPGVPEKSLGGSSLTETEAA 543 PG P + G +GP P + P K P P K G + ++ Sbjct: 115 ---PGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSR 171 Query: 544 PSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICEN 603 S + P PQ P Q + P P P +GG + Sbjct: 172 SSRSPPGK---PQGPPPQGGNQ--------------PQGPPPPPGKPQGPPPQGGNKPQG 214 Query: 604 GADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPP 663 K P PPQ + P GP PP+ +P PP P PP Sbjct: 215 PPPPGKPQGP-----PPQGDNKSQSARSPPGKPQGP--PPQGGNQPQGPPPPPGKPQGPP 267 Query: 664 ----KATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEK 719 GP P K GP P + S + + P + GP P K Sbjct: 268 PQGGNKPQGPPPPGK-PQGP--PPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGK 324 Query: 720 PASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLS 779 P ++ +G P + P QG S + ++ PG + P + + Q Sbjct: 325 PQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRS--ARSPPGKPQGPPQQEGNNPQGP-- 380 Query: 780 REVAVVMPTLARGGAAGP-----GEPVEVKEPP--GLPAKPP 814 P A G P G+P PP G P++PP Sbjct: 381 -------PPPAGGNPQQPQAPPAGQPQGPPRPPQGGRPSRPP 415 Score = 44.7 bits (104), Expect = 5e-04 Identities = 44/173 (25%), Positives = 62/173 (35%), Gaps = 20/173 (11%) Query: 953 NLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSP 1012 N PQG P P PP + + + + PPP+ N P+ P P G+ P Sbjct: 210 NKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPP---GKPQGP 266 Query: 1013 PRNNYSDLRQLPNAG-PGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEP 1071 P + + P G P PP G S+ + G GG + P Sbjct: 267 PPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQ--------GP 318 Query: 1072 HRGPGLPHGGTGRSLSSPNCFGPQPGG------PEMRRVNSAGRAPPGGLHAP 1118 PG P G + + P GP P G P+ + + R+PPG P Sbjct: 319 PPPPGKPQGPPPQGGNKPQ--GPPPPGKPQGPPPQGGSKSRSARSPPGKPQGP 369 Score = 43.5 bits (101), Expect = 0.001 Identities = 99/423 (23%), Positives = 126/423 (29%), Gaps = 85/423 (20%) Query: 619 PPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPP----KATLGPATPLK 674 PPQ P GP PP+ +P PP P PP GP P K Sbjct: 40 PPQGGNKPQGPPSPPGKPQGP--PPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGK 97 Query: 675 ATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGE 734 P K+ S P P + P G+P+ P Q + P +G Sbjct: 98 PQGPPPQGDKSRS-PRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKP---QGP 153 Query: 735 GSPSEATRLPTQG---ARSSAAFPPKTS---PGGGEVPCLYKPHCHQSSLSREVAVVMPT 788 P + P QG +RSS + P K P GG P P P Sbjct: 154 PPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPP--------------PG 199 Query: 789 LARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHP--------------VTGEVVE 834 +G G + PPG P PP + R P G Sbjct: 200 KPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPP 259 Query: 835 RGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTV 894 G P + Q G G GS ++ +S QG P Sbjct: 260 PGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGS------KSRSSRSPPGKPQGPPPQGGN 313 Query: 895 VPKLPKEAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNL 954 P+ P P G G +G +PQ P P Sbjct: 314 QPQGP-------------PPPPGKPQGPPPQGGN----------KPQGP------PPPGK 344 Query: 955 PQGHPL---PKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSS 1011 PQG P KS S+ P + ++E N PPPP N +P AP G+ Sbjct: 345 PQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPP---AGQPQG 401 Query: 1012 PPR 1014 PPR Sbjct: 402 PPR 404 Score = 43.5 bits (101), Expect = 0.001 Identities = 43/174 (24%), Positives = 59/174 (33%), Gaps = 22/174 (12%) Query: 953 NLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPE--PPAPALQYLGRQS 1010 N PQG P P PP + + + PPP+ N P+ PP P Q Sbjct: 148 NKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKP----QG 203 Query: 1011 SPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGE 1070 PP+ P P PP G ++ + G GG + Sbjct: 204 PPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQP--------QG 255 Query: 1071 PHRGPGLPHGGTGRSLSSPNCFGPQPGG------PEMRRVNSAGRAPPGGLHAP 1118 P PG P G + + P GP P G P+ + + R+PPG P Sbjct: 256 PPPPPGKPQGPPPQGGNKPQ--GPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGP 307 Score = 42.7 bits (99), Expect = 0.002 Identities = 98/421 (23%), Positives = 127/421 (30%), Gaps = 72/421 (17%) Query: 709 KDSGPAGQPEKPASQEVSTPSQARGEGSP-SEATRLPTQGARSSAAFPPKTSPGGGEVPC 767 K GP P KP +Q +G P + P QG PP P G Sbjct: 46 KPQGPPSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPP-- 103 Query: 768 LYKPHCHQSSLSREVAVVMPTLARGGAAGP-----GEPVEVKEPPGLPAKPPASAQPTDE 822 Q SR P G GP +P PPG P PP Q ++ Sbjct: 104 -------QGDKSRS-----PRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPP--QGGNK 149 Query: 823 LLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSI 882 P G+ +G P Q K RS + G+ P +Q + Sbjct: 150 PQGPPPPGK--PQGPPP-------QGDNKSRSSRSPPGKPQGPPP--QGGNQPQGPPPPP 198 Query: 883 FHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKW-------GPRLGRDAEGTELSRRHNW 935 QG P P+ P K + NK G G +G + Sbjct: 199 GKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPP 258 Query: 936 TKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSND 995 +PQ P N PQG P P PP + + PPP+ N Sbjct: 259 PPGKPQGPPP----QGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQ 314 Query: 996 PE--PPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGLER 1053 P+ PP P Q PP+ P P PP G S+ + G + Sbjct: 315 PQGPPPPPGKP----QGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPG-----K 365 Query: 1054 FSGGGRSLIKKRLYVGEPHRGPGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPG 1113 G + G +GP P GG + +P QP GP R P G Sbjct: 366 PQGPPQQ-------EGNNPQGPPPPAGGNPQQPQAPP--AGQPQGPP--------RPPQG 408 Query: 1114 G 1114 G Sbjct: 409 G 409 Score = 37.7 bits (86), Expect = 0.066 Identities = 52/214 (24%), Positives = 67/214 (31%), Gaps = 38/214 (17%) Query: 953 NLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSP 1012 N PQG P P PP P + + PPP+ N P+ P P G+ P Sbjct: 87 NKPQGPPPPGKPQGPP-PQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPP---GKPQGP 142 Query: 1013 PRNNYSDLRQLPNAG-PGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEP 1071 P + + P G P PP G ++ S RS Sbjct: 143 PPQGGNKPQGPPPPGKPQGPPPQGDNK----------------SRSSRS----------- 175 Query: 1072 HRGPGLPHGGTGRSLSSPNCFGPQPG---GPEMRRVNSA-GRAPPGGLHAPRLSLEGAAR 1127 PG P G + + P P PG GP + N G PPG P + ++ Sbjct: 176 --PPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQ 233 Query: 1128 GAAEAKHKAPGSADYGFAPAAGRSPYTTTRYGSP 1161 A K G G G P G P Sbjct: 234 SARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPP 267 Score = 37.7 bits (86), Expect = 0.066 Identities = 26/87 (29%), Positives = 30/87 (34%), Gaps = 4/87 (4%) Query: 130 PGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPS---- 185 P Q G PPPP P PPQ S+ P P P + PPPP+ Sbjct: 329 PPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPPPPAGGNP 388 Query: 186 MAPPPPPVLEALSPPHTLSSPSIPTPP 212 P PP + PP PP Sbjct: 389 QQPQAPPAGQPQGPPRPPQGGRPSRPP 415 Score = 35.4 bits (80), Expect = 0.33 Identities = 52/212 (24%), Positives = 65/212 (30%), Gaps = 52/212 (24%) Query: 955 PQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPR 1014 PQG P+ PPSP K + PPP+ N P+ P P G+ PP Sbjct: 41 PQGGNKPQG---PPSPPGKPQG-----------PPPQGGNQPQGPPPPP---GKPQGPPP 83 Query: 1015 NNYSDLRQLPNAG-PGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHR 1073 + + P G P PP G K R P Sbjct: 84 QGGNKPQGPPPPGKPQGPPPQGD--------------------------KSR----SPRS 113 Query: 1074 GPGLPHGGTGRSLSSPNCFGPQPG---GPEMRRVNSA-GRAPPGGLHAPRLSLEGAARGA 1129 PG P G + + P P PG GP + N G PPG P + +R + Sbjct: 114 PPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSS 173 Query: 1130 AEAKHKAPGSADYGFAPAAGRSPYTTTRYGSP 1161 K G G G P G P Sbjct: 174 RSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPP 205 >gi|110349719 titin isoform N2-A [Homo sapiens] Length = 33423 Score = 108 bits (271), Expect = 2e-23 Identities = 173/686 (25%), Positives = 248/686 (36%), Gaps = 113/686 (16%) Query: 138 LIPPPPPG----PAPGPPQDISEPPGGSPL------PSPPSTAPPPPPLLLEP------- 180 +IPP P P PP + E P + P P P P +L P Sbjct: 10449 IIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKVPEVLPPKEVVPEK 10508 Query: 181 --PPPPSMAP--PPPPVLEALSPPHTLSSPSIPTPPDFIPPAPP-----LAFLAPPPPPV 231 P PP+ P PPP V EA P + +P PP P PP + A P V Sbjct: 10509 KVPVPPAKKPEAPPPKVPEA--PKEVVPEKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKV 10566 Query: 232 PAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAE--------- 282 P PP P SP P V K A ++ E T P +P E Sbjct: 10567 PEAIPPKPESPPPEVPE--APKEVVPEKKVPAAPPKKPEVTPVKVPEAPKEVVPEKKVPV 10624 Query: 283 --PKGSALGPN--PE-PHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSR 337 PK + P PE P + P KVP P + S P + +E EE A ++ P+ Sbjct: 10625 PPPKKPEVPPTKVPEVPKVAVPEK-KVPEAIPPKPESPPPEVFEE---PEEVALEEPPAE 10680 Query: 338 LPLPPSFHIRPASQVYPDR-APEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPL 396 + P P V P + PE P A P L + + P PL Sbjct: 10681 VVEEPEPAAPPQVTVPPKKPVPEKKAP----AVVAKKPELPPVKVPEVPKEVVPEKKVPL 10736 Query: 397 PPPAPPLPPPA--PPLPPAAPP---LPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPE 451 P P PPA P +P P + +K PPA + PK P L+ KP P PE Sbjct: 10737 VVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVPK--KPVLEEKPAVPVPE 10794 Query: 452 NTASSAPVDWRDPSQM---EKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKE---GKK 505 S P + +P ++ E++ E + + E+ P P V + K+ KK Sbjct: 10795 RAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEE---PEVPPPAVPEEPKKIIPEKK 10851 Query: 506 ----------GPRLPEKETLLS----LPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSV 551 P+ PE E ++ P PP P K + + +A P +P Sbjct: 10852 VPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEK 10911 Query: 552 DYIPQD-SPTP-----SVRQIRNELEARLSSAAEKEAKPSIGSLPP---KPRLEGGRICE 602 +P+ TP +++R L R E+ S+ P +P++E ++ Sbjct: 10912 PQVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVEPKKL-- 10969 Query: 603 NGADDDKLSKPVAKNLPPQ---STTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWP 659 +K+ KP PP +PT + + + + P P+ +PAIP A P Sbjct: 10970 -----EKVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTKVPEI--KPAIPLPAP-EP 11021 Query: 660 ATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGP-AGQPE 718 P+A + P PT + P + A + A K GP G P+ Sbjct: 11022 KPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKKA---EAKAPKEEAAKPKGPIKGVPK 11078 Query: 719 KPASQEVSTPSQAR----GEGSPSEA 740 K S + + R GE P EA Sbjct: 11079 KTPSPIEAERRKLRPGSGGEKPPDEA 11104 Score = 106 bits (264), Expect = 2e-22 Identities = 184/744 (24%), Positives = 256/744 (34%), Gaps = 125/744 (16%) Query: 157 PPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAP--------------------PPPPVLEA 196 PP G + PP ++ PP+ P PP V E Sbjct: 10439 PPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKVPEV 10498 Query: 197 LSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVP---APAPPAPASPHTVGTRL--FP 251 L P + +P PP P APP P VP P PP P P T++ P Sbjct: 10499 LPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPP-PKKPEVPPTKVPEVP 10557 Query: 252 PGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVR 311 V + K A+ + + PP P PK PE KVP P + Sbjct: 10558 KAAVPEKKVPEAIPPK----PESPPPEVPEAPKEVV----PEK--------KVPAAPPKK 10601 Query: 312 TSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAP 371 PV + EAP KE KK P P P +V PE P E P Sbjct: 10602 PEVTPV-KVPEAP-KEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVP-EAIPPKP 10658 Query: 372 ASPRLGQSQSQADERAGTPPPAPPLPPPAPPLP-----PPAPPLPPAAPPLPCAQKAAHP 426 SP + + +E A PPA + P P P PP P+P P A+K P Sbjct: 10659 ESPP-PEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELP 10717 Query: 427 PAGFTKTPKSSSPALK-PKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRRED 485 P + PK P K P P PE AP P+++ ++ E+ + Sbjct: 10718 PVKVPEVPKEVVPEKKVPLVVPKKPE-----AP-----PAKVPEVPKEVV--------PE 10759 Query: 486 RFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLP-------AKDTPPGV---PEKSLGGS 535 + ++ P V P K P +P+K L P A+ PP V PE+ Sbjct: 10760 KKVAVPKKPEVPP-----AKVPEVPKKPVLEEKPAVPVPERAESPPPEVYEEPEEIAPEE 10814 Query: 536 SLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNEL--EARLSSAAEKEAKPSIGSLPPKP 593 + E P +P + + P P+V + ++ E ++ + EA P P +P Sbjct: 10815 EIAPEEEKP---VPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPP-----PKEP 10866 Query: 594 RLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPE-PAIP 652 E + KP K PP P ++ K AIP K PE P +P Sbjct: 10867 EPE-----------KVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVP 10915 Query: 653 PKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLM------ 706 K L TP K G K P + + S P + Sbjct: 10916 EKVEL---TPLKVPGGEKKVRKLL--PERKPEPKEEVVLKSVLRKRPEEEEPKVEPKKLE 10970 Query: 707 -AEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLP-TQGARSSAAFPPKTSPGGGE 764 +K + P P KP +EV P+ + E E T++P + A A PK P E Sbjct: 10971 KVKKPAVPEPPPPKPV-EEVEVPTVTKRERKIPEPTKVPEIKPAIPLPAPEPKPKP-EAE 11028 Query: 765 VPCLYKPHCHQSSLSREVAVVMPTLA-RGGAAGPGEPVEVKEPP--GLPAKPPASAQPTD 821 V + P V +P + + A P E + P G+P K P+ + Sbjct: 11029 VKTIKPPPVEPEPTPIAAPVTVPVVGKKAEAKAPKEEAAKPKGPIKGVPKKTPSPIEAER 11088 Query: 822 ELLRHPVTGEVVERGSPMALLLAA 845 LR GE +P L A Sbjct: 11089 RKLRPGSGGEKPPDEAPFTYQLKA 11112 Score = 91.3 bits (225), Expect = 5e-18 Identities = 207/942 (21%), Positives = 303/942 (32%), Gaps = 175/942 (18%) Query: 137 LLIPP---PPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPP--PLLLEPPPPPSMAPPPP 191 +LIP PPP P P+ P P+P P PP P + + P P P P Sbjct: 9991 VLIPKKEKPPPAKVPEVPKK-PVPEEKVPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPA 10049 Query: 192 PVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPP------PVPAPAPPAPASPHTV 245 P P P P + P P APPP PVP P Sbjct: 10050 PKKVEAPPAKVPEVPKKLIPEEKKPTPVPKKVEAPPPKVPKKREPVPVPVALPQEEEVLF 10109 Query: 246 GTRLFPPGGVTKWKSDVALNGRQA--EATRASPPRSPAEPKGSALGPN-----------P 292 + P V + +V + E P P+ + P P Sbjct: 10110 EEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVP 10169 Query: 293 EPHLTFPRSFKVPPPTPVRTSSIPVQEAQEA-PRKEEGATKKAPS--------RLPLPPS 343 E + KVP P PV V E + P+KEE K P R+ LP Sbjct: 10170 EEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEAPPAKVPEVPKKVEEKRIILPKE 10229 Query: 344 FHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPL 403 + P +V + EP E+ P S + +E A PP P + A P Sbjct: 10230 EEVLPV-EVTEEPEEEPISEEEIPEEPP-------SIEEVEEVA--PPRVPEVIKKAVPE 10279 Query: 404 PPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRD 463 P P APP ++K K + PA P+ PE V ++ Sbjct: 10280 APTPVPKKVEAPPAKVSKKIPEEKVPVPVQKKEAPPAKVPEVPKKVPE---KKVLVPKKE 10336 Query: 464 PSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDT 523 K R L + + R++ + R V E +PE+E + Sbjct: 10337 AVPPAKGRTVLEEKVSVAFRQEVVVKERLELEVVEAEVE-----EIPEEEEFHEV----- 10386 Query: 524 PPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAK 583 E+ E E L V+ ++ V ++ EA EK Sbjct: 10387 -----EEYFEEGEFHEVEEFIKLEQHRVE---EEHRVEKVHRVIEVFEAEEVEVFEKPKA 10438 Query: 584 PSIGS------LPPK-----------PRLEGGRICENGADDDKLSKPVAKNLPPQST-TL 625 P G +PPK P + + + ++K+ P +PP + Sbjct: 10439 PPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKVPEV 10498 Query: 626 LPTTSLQP--KAMLGPAIPPKATPEPAIP--PKATL----WPATPPKATLGPATPLKATS 677 LP + P K + PA P+A P P +P PK + P PPK P T + Sbjct: 10499 LPPKEVVPEKKVPVPPAKKPEA-PPPKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVP 10557 Query: 678 GPTTPLKATS---GPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGE 734 P K P S +P +++ EK PA P+KP V P +A E Sbjct: 10558 KAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEK-KVPAAPPKKPEVTPVKVP-EAPKE 10615 Query: 735 GSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGA 794 P + +P PPK EVP P EV V Sbjct: 10616 VVPEKKVPVP----------PPKKP----EVPPTKVP---------EVPKV--------- 10643 Query: 795 AGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMA---LLLAARQRAQK 851 A P + V PP + PP + +E+ EVVE P A + + ++ + Sbjct: 10644 AVPEKKVPEAIPPKPESPPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPE 10703 Query: 852 GRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTE 911 ++ + LP VP++PKE + + Sbjct: 10704 KKAPAVVAKKPELPP--------------------------VKVPEVPKEVVPEKKVPLV 10737 Query: 912 IPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWE-RVAPSNLPQGHPLPKSFSSPPSP 970 +P K +A ++ PE + V + V P+ +P+ P P P Sbjct: 10738 VPKK------PEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEEKPAVP 10791 Query: 971 SNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSP 1012 +R E PPPE +PE AP + + P Sbjct: 10792 VPERAES----------PPPEVYEEPEEIAPEEEIAPEEEKP 10823 Score = 73.9 bits (180), Expect = 8e-13 Identities = 136/634 (21%), Positives = 217/634 (34%), Gaps = 108/634 (17%) Query: 139 IPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALS 198 + P P P P P+ + P P P P P L+PPPP P E + Sbjct: 9795 VKPVPEEPVPTKPK--APPAKVLKKAVPEEKVPVPIPKKLKPPPPKVPEEPKKVFEEKIR 9852 Query: 199 PPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKW 258 T T P P P +A PVP P V L P Sbjct: 9853 ISITKREKEQVTEPAAKVPMKPKRVVAEEKVPVPRKEVAPPVRVPEVPKELEP------- 9905 Query: 259 KSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQ 318 +VA E E + + E F +V P PV+ +P + Sbjct: 9906 -EEVAFE----EEVVTHVEEYLVEEEEEYIHEEEE----FITEEEVVPVIPVKVPEVPRK 9956 Query: 319 EAQE------APRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPA 372 E P+K+E P+++P P +P +V P P+ + P K P Sbjct: 9957 PVPEEKKPVPVPKKKEA----PPAKVPEVPK---KPEEKV-PVLIPKKEKPPPAK--VPE 10006 Query: 373 SPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTK 432 P+ + +E+ P P PPA P P+P P+P +K PPA + Sbjct: 10007 VPK----KPVPEEKVPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPE 10062 Query: 433 TPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHR- 491 PK L P+ P+P AP P ++ K R + + + E+ Sbjct: 10063 VPKK----LIPEEKKPTPVPKKVEAP-----PPKVPKKREPVPVPVALPQEEEVLFEEEI 10113 Query: 492 -PGPTVAPQSKE--GKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTL 548 P V P+ +E ++ LPE+E +L ++ PP E E P Sbjct: 10114 VPEEEVLPEEEEVLPEEEEVLPEEEEVLP-EEEEIPP-------------EEEEVP---- 10155 Query: 549 PSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDD 608 P +Y+P++ ++ E KP + P P + + + Sbjct: 10156 PEEEYVPEEEEFVPEEEVL------------PEVKPKVPVPAPVPEI------KKKVTEK 10197 Query: 609 KLSKPVAKNLPPQSTTLLPTTSLQPKAMLGP----AIPPKATPEPAIPP-KATLWPATPP 663 K+ P + PP +P ++ K ++ P +P + T EP P P PP Sbjct: 10198 KVVIPKKEEAPPAKVPEVP-KKVEEKRIILPKEEEVLPVEVTEEPEEEPISEEEIPEEPP 10256 Query: 664 KATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQ 723 ++ + P P A+ T +P + ++ PA +K + Sbjct: 10257 S-----IEEVEEVAPPRVP--EVIKKAVPEAPTPVP-------KKVEAPPAKVSKKIPEE 10302 Query: 724 EVSTPSQARGEGSPSEATRLPTQGARSSAAFPPK 757 +V P Q + E P++ +P + P K Sbjct: 10303 KVPVPVQKK-EAPPAKVPEVPKKVPEKKVLVPKK 10335 Score = 69.3 bits (168), Expect = 2e-11 Identities = 84/343 (24%), Positives = 118/343 (34%), Gaps = 50/343 (14%) Query: 137 LLIPPPPPGPAPGPPQDISE--PPGGSPLPSPPSTAP------PPPPLLLEPP--PPPSM 186 L++P P P P+ E P +P P P P P+L E P P P Sbjct: 10736 LVVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEEKPAVPVPER 10795 Query: 187 APPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVG 246 A PPP E P + +P P+ P P P PP P P P Sbjct: 10796 AESPPP--EVYEEPEEI-APEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKV 10852 Query: 247 TRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPP 306 + P A PP+ P EP+ P +P P PP Sbjct: 10853 PVIKKP--------------------EAPPPKEP-EPEKVIEKPKLKPRPPPP-----PP 10886 Query: 307 PTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPP---SFHIRPASQVYPDRAPEPDCP 363 P + + + P+K+ + P ++ L P + ++ P+R PEP Sbjct: 10887 APPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEE 10946 Query: 364 GELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLP-------PAAPP 416 LK+ P + + + + PA P PPP P+ P P Sbjct: 10947 VVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTK 11006 Query: 417 LPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPV 459 +P + A PA K PK + KP P PE T +APV Sbjct: 11007 VPEIKPAIPLPAPEPK-PKPEAEVKTIKPPPVEPEPTPIAAPV 11048 Score = 59.3 bits (142), Expect = 2e-08 Identities = 122/608 (20%), Positives = 192/608 (31%), Gaps = 104/608 (17%) Query: 139 IPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALS 198 I PPP P P+ I P P P P PPP + EP P PP V++ Sbjct: 9572 IEEPPPAKVPEAPKKIV-PEKKVPAPVPKKEKVPPPKVPEEPKKPVPEKKVPPKVIKMEE 9630 Query: 199 PPHTLSSPSIPTPPDFIPPAPPLAFLA----PPPPPVPAPAPPAPASPHTVGTRLFP--- 251 P P+ T +A PP P P A P +L P Sbjct: 9631 P-----LPAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLKLKPKRE 9685 Query: 252 ---PGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPT 308 P VT+++ V ++ + + +P R P K + E T Sbjct: 9686 EEPPAKVTEFRKRVV---KEEKVSIEAPKREPQPIKEVTIMEEKERAYT----------- 9731 Query: 309 PVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKA 368 + ++ VQ +E EE K+ P + Y +R E Sbjct: 9732 -LEEEAVSVQREEEYEEYEEYDYKEFEEYEPTEEYDQY----EEYEEREYE--------- 9777 Query: 369 TAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPA 428 R + + E P P P P+P P P APP +KA Sbjct: 9778 ------RYEEHEEYITE--------PEKPIPVKPVPEEPVPTKPKAPPAKVLKKA----- 9818 Query: 429 GFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFL 488 P+ P PK P P P + +K+ E R +++ Sbjct: 9819 ----VPEEKVPVPIPKKLKPPPPKV----------PEEPKKVFEEKIRISITKREKEQVT 9864 Query: 489 SHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTL 548 + P+ ++ +P KE + + P + + + T L Sbjct: 9865 EPAAKVPMKPKRVVAEEKVPVPRKEVAPPVRVPEVPKELEPEEVAFEEEVVTHVEEYLVE 9924 Query: 549 PSVDYIPQDSPTPSVRQIRNELEARLSSAAEK----EAKPSIGSLPPKPRLEGGRICENG 604 +YI ++ + ++ + ++ K E KP +P K ++ E Sbjct: 9925 EEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPEEKKPV--PVPKKKEAPPAKVPE-- 9980 Query: 605 ADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIP-PKATLWPATPP 663 V K + L+P P A + P +P K PE +P P A P Sbjct: 9981 ---------VPKKPEEKVPVLIPKKEKPPPAKV-PEVPKKPVPEEKVPVPVPKKVEAPPA 10030 Query: 664 KATLGPATPLKATSGPT-TPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPAS 722 K P P+ P P K + PA +P +L+ E + P P+K + Sbjct: 10031 KVPEVPKKPVPEKKVPVPAPKKVEAPPA------KVPEVPKKLIPE-EKKPTPVPKKVEA 10083 Query: 723 QEVSTPSQ 730 P + Sbjct: 10084 PPPKVPKK 10091 Score = 56.2 bits (134), Expect = 2e-07 Identities = 98/433 (22%), Positives = 144/433 (33%), Gaps = 75/433 (17%) Query: 140 PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPP--PLLLEPPPPPSMAPPPPPVLEAL 197 PPP P P P +P+P P PP P P + + P P P P P E Sbjct: 9284 PPPKVPELPEKPA----PEEVAPVPIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPA 9339 Query: 198 SPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVP-----------------APAPPAPA 240 +PP P P P + I P P PP VP P PA Sbjct: 9340 APPKVPEVPKKPVPEEKI-PVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPA 9398 Query: 241 SPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPR 300 P P V + + V + E PP+ PA PK P + + P Sbjct: 9399 VPE------IPKKKVPEERKPVP----RKEEEVPPPPKVPALPKKPV--PEEKVAVPVPV 9446 Query: 301 SFKVPPPTPVRTSSIPVQE----AQE-----APRKEEGATKKAPSRLPLPPSFHIRPAS- 350 + K PPP + V+E A+E P++ E + + S S Sbjct: 9447 AKKAPPPRAEVSKKTVVEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSI 9506 Query: 351 QVYPDRAPEPDCPGEL---------------KATAPASPRLGQSQSQADERAGTPPPAPP 395 VY + E + E+ + S R+ ++ ER P Sbjct: 9507 SVYREEEREEEEEAEVTEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKP 9566 Query: 396 LPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTAS 455 P PPPA P AP +K PA K K P + +P P PE Sbjct: 9567 KIPAKIEEPPPAK--VPEAPKKIVPEKKV--PAPVPKKEKVPPPKVPEEPKKPVPEKKVP 9622 Query: 456 SAPVDWRDPSQMEKLRNELAAYLCGSRREDRFL---SHRPGPTVAPQSKEGKKGPRLPEK 512 + +P + + +E++ L + + P A +E K+ +PE+ Sbjct: 9623 PKVIKMEEPLPAKVTERHMQI-----TQEEKVLVAVTKKEAPPKARVPEEPKRA--VPEE 9675 Query: 513 ETLLSLPAKDTPP 525 + L P ++ P Sbjct: 9676 KVLKLKPKREEEP 9688 Score = 54.7 bits (130), Expect = 5e-07 Identities = 93/414 (22%), Positives = 137/414 (33%), Gaps = 72/414 (17%) Query: 255 VTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSS 314 VT+ K VA++ R PP+ P P+ P PE P KV PP P Sbjct: 9269 VTEEKIHVAISKRVEP-----PPKVPELPEK----PAPEEVAPVPIPKKVEPPAP----- 9314 Query: 315 IPVQEAQEAPRKEEGATKKAPSRLPL-PPSFHIRPASQVYPDRAPEPDCPGELKATAPAS 373 V E + P EE P + P PP P V ++ P P + K PA Sbjct: 9315 -KVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVP--VAKKKEAPPAK 9371 Query: 374 PRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKT 433 Q +E+ PPPA P P +P P+P ++ PP Sbjct: 9372 VPEVQKGVVTEEKITIVTQREESPPPAVP-EIPKKKVPEERKPVPRKEEEVPPPPKVPAL 9430 Query: 434 PKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPG 493 PK KP P E A PV + P ++ + E RF++ Sbjct: 9431 PK------KPVPE----EKVAVPVPVAKKAPPPRAEVSKKTVV------EEKRFVAEEKL 9474 Query: 494 PTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDY 553 PQ E + E+E S E+ + S E E +Y Sbjct: 9475 SFAVPQRVEVTRHEVSAEEEWSYS---------EEEEGVSISVYREEEREEEEEAEVTEY 9525 Query: 554 IPQDSPTPSVRQ-----IRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDD 608 + P V + I +EA + E++ K + KP++ Sbjct: 9526 EVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEK----KIVLKPKIPA----------- 9570 Query: 609 KLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPP--------KATPEPAIPPK 654 K+ +P +P ++P + +PP K PE +PPK Sbjct: 9571 KIEEPPPAKVPEAPKKIVPEKKVPAPVPKKEKVPPPKVPEEPKKPVPEKKVPPK 9624 Score = 51.6 bits (122), Expect = 4e-06 Identities = 163/802 (20%), Positives = 246/802 (30%), Gaps = 162/802 (20%) Query: 139 IPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAP---------P 189 + PP P P + + E P+P APP P + + P P P P Sbjct: 9309 VEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVAKKKEAP 9368 Query: 190 PPPVLEALSPPHTLSSPSIPT-----PPDFIP------------PAPPLAFLAPPPPPVP 232 P V E T +I T PP +P P P PPPP VP Sbjct: 9369 PAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVP 9428 Query: 233 A-PAPPAP----ASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSA 287 A P P P A P V + PP ++ T R AE K Sbjct: 9429 ALPKKPVPEEKVAVPVPVAKKAPPP------------RAEVSKKTVVEEKRFVAEEK--- 9473 Query: 288 LGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIR 347 SF VP V + +E +EEG + Sbjct: 9474 ------------LSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREEEREEEEEAE 9521 Query: 348 PASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPL----PPPAPPL 403 + E +L + ++ E+ P P PPPA Sbjct: 9522 VTEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVP 9581 Query: 404 PPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKP-----NPPSPEN------ 452 P +P P P +K PP + PK P K P P P Sbjct: 9582 EAPKKIVPEKKVPAPVPKKEKVPPPKVPEEPKKPVPEKKVPPKVIKMEEPLPAKVTERHM 9641 Query: 453 ------------TASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQS 500 T AP R P + ++ + E++ L +P P + Sbjct: 9642 QITQEEKVLVAVTKKEAPPKARVPEEPKR-----------AVPEEKVLKLKPKREEEPPA 9690 Query: 501 KEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSV--------- 551 K + R+ ++E + K P + E ++ + E E A +L +V Sbjct: 9691 KVTEFRKRVVKEEKVSIEAPKREPQPIKEVTI----MEEKERAYTLEEEAVSVQREEEYE 9746 Query: 552 -----DY--IPQDSPTPSVRQIRNELEARLSSAAEKE-----------AKP-SIGSLPPK 592 DY + PT Q E E E KP +P K Sbjct: 9747 EYEEYDYKEFEEYEPTEEYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEEPVPTK 9806 Query: 593 PRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKAT------ 646 P+ ++ + ++K+ P+ K L P P +PK + I T Sbjct: 9807 PKAPPAKVLKKAVPEEKVPVPIPKKLKPPP----PKVPEEPKKVFEEKIRISITKREKEQ 9862 Query: 647 -PEPA----IPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTT 701 EPA + PK + P A P++ P P + P + + T Sbjct: 9863 VTEPAAKVPMKPKRVVAEEKVPVPRKEVAPPVRV---PEVPKELE--PEEVAFEEEVVTH 9917 Query: 702 TSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPG 761 + + E++ + E+ ++E P E R P + P K Sbjct: 9918 VEEYLVEEEEEYIHEEEEFITEEEVVPVI---PVKVPEVPRKPVPEEKKPVPVPKKKEAP 9974 Query: 762 GGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAG----PGEPV-EVKEPPGLPAKPPAS 816 +VP + K +V V++P + A P +PV E K P +P K A Sbjct: 9975 PAKVPEVPK------KPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPVPKKVEAP 10028 Query: 817 AQPTDELLRHPVTGEVVERGSP 838 E+ + PV + V +P Sbjct: 10029 PAKVPEVPKKPVPEKKVPVPAP 10050 Score = 48.5 bits (114), Expect = 4e-05 Identities = 148/714 (20%), Positives = 215/714 (30%), Gaps = 98/714 (13%) Query: 136 DLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLE 195 +L P P P P I P P PP APP P LL P P PPP +E Sbjct: 8931 ELKPPDIPDSRVPIPTMPIRAVP---PEEIPPVVAPPIPLLL----PTPEEKKPPPKRIE 8983 Query: 196 ALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPP-VPAPAPPAPASPHTVGTRLFPPGG 254 + + P + P + PPP +PA AP Sbjct: 8984 VTKKAVKKDAKKVVAKPKEMTPREEIVKKPPPPTTLIPAKAPEI---------------- 9027 Query: 255 VTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPH---LTFPRSFKVPPPTPVR 311 DV+ + + + + + K + H F SF+ P Sbjct: 9028 -----IDVSSKAEEVKIMTITRKKEVQKEKEAVYEKKQAVHKEKRVFIESFEEPYD---E 9079 Query: 312 TSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIR-----PASQVYPDRAPEPDCPGEL 366 P E E P EE ++ H Q Y +R D E Sbjct: 9080 LEVEPYTEPFEQPYYEEPDEDYEEIKVEAKKEVHEEWEEDFEEGQEYYEREEGYDEGEEE 9139 Query: 367 KATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHP 426 A + Q Q + E + +P P PP P +++ Sbjct: 9140 WEEAYQEREVIQVQKEVYEESHERKVPAKVPEKKAPPPPKVIKKPVIEKIEKTSRRMEEE 9199 Query: 427 PAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGS---RR 483 TK P+ S + KP+ R P Q E + ++ A Sbjct: 9200 KVQVTKVPEVSKKIVPQKPS---------------RTPVQEEVIEVKVPAVHTKKMVISE 9244 Query: 484 EDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAA 543 E F + V+ E +K EK + + PP VPE E A Sbjct: 9245 EKMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAISKRVEPPPKVPELP---EKPAPEEVA 9301 Query: 544 PSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICEN 603 P V+ P + + E + E A P + +P KP Sbjct: 9302 PVPIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKP---------- 9351 Query: 604 GADDDKLSKPVA--KNLPP-------------QSTTLLPTTSLQPKAMLGPAIPPKATPE 648 ++K+ PVA K PP + T++ P + P IP K PE Sbjct: 9352 -VPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAV-PEIPKKKVPE 9409 Query: 649 PAIP-PKATLWPATPPKATLGPATPL--KATSGPTTPLKATSGPAIASTATTLPTTTSQL 705 P P+ PPK P P+ + + P K P + T+ + Sbjct: 9410 ERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKAPPPRAEVSKKTVVEEKRFV 9469 Query: 706 MAEKDSGPAGQPEKPASQEVSTPSQ-ARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGE 764 EK S Q + EVS + + E + + + R T E Sbjct: 9470 AEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREEEREEEEEAEVTEYEVME 9529 Query: 765 VPCLY----KPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPP 814 P Y K H + E A V + P P +++EPP PAK P Sbjct: 9530 EPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPP--PAKVP 9581 Score = 47.4 bits (111), Expect = 8e-05 Identities = 107/519 (20%), Positives = 182/519 (35%), Gaps = 138/519 (26%) Query: 504 KKGPRLPEKETLLSL--PAKDTPPGV-PEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPT 560 +K R P +E ++ + PA T V E+ + +S TE E S+T+P V Sbjct: 9216 QKPSRTPVQEEVIEVKVPAVHTKKMVISEEKMFFASHTEEEV--SVTVPEVQ-------- 9265 Query: 561 PSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPP 620 ++I E + ++ + E P + LP KP A ++ P+ K + P Sbjct: 9266 ---KEIVTEEKIHVAISKRVEPPPKVPELPEKP-----------APEEVAPVPIPKKVEP 9311 Query: 621 QSTTLLPTTSLQPKAMLGPAIPPKATPEPAIP-PKATLWPATPPKATLGPATPLKATSGP 679 + PK P +P K PE P P PA PPK P P+ P Sbjct: 9312 PA----------PKV---PEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIP 9358 Query: 680 TTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKP---ASQEVSTPSQARGEGS 736 K +K++ PA PE ++E T R E Sbjct: 9359 VPVAK-----------------------KKEAPPAKVPEVQKGVVTEEKITIVTQREESP 9395 Query: 737 PSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAG 796 P +P + +VP KP Sbjct: 9396 PPAVPEIPKK-----------------KVPEERKPV------------------------ 9414 Query: 797 PGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVG 856 P + EV PP +PA P +E + PV V ++ P ++ + ++ R V Sbjct: 9415 PRKEEEVPPPPKVPALPKKPVP--EEKVAVPVP--VAKKAPPPRAEVSKKTVVEEKRFVA 9470 Query: 857 AALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTT----EI 912 ++P + H+ A + + + S +V + +E E+++ +T E Sbjct: 9471 EEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREEEREEEEEAEVTEYEVMEE 9530 Query: 913 PNKW---------GPRLGRDAEGTELS-RRHNWTKPEPQAPVAWERVAPSNLPQGHPLPK 962 P ++ R+ +AE E++ R+ +P+ P E P+ +P+ Sbjct: 9531 PEEYVVEEKLHIISKRV--EAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIV 9588 Query: 963 SFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAP 1001 P+P K+E+ PPP+ +P+ P P Sbjct: 9589 PEKKVPAPVPKKEKV----------PPPKVPEEPKKPVP 9617 Score = 34.3 bits (77), Expect = 0.73 Identities = 31/119 (26%), Positives = 51/119 (42%), Gaps = 6/119 (5%) Query: 349 ASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLP--PPAPPLPPP 406 A Q P + P P P + K+ +P P + A +++ +P P P P P P Sbjct: 245 AGQQLPHKTP-PRIPPKPKSRSPTPPSIAAKAQLARQQSPSPIRHSPSPVRHVRAPTPSP 303 Query: 407 APPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPEN--TASSAPVDWRD 463 + PAA ++ P KT ++S+ A P+ PP + ASS+ + R+ Sbjct: 304 VRSVSPAARISTSPIRSVRSPLLMRKT-QASTVATGPEVPPPWKQEGYVASSSEAEMRE 361 Score = 32.3 bits (72), Expect = 2.8 Identities = 34/120 (28%), Positives = 42/120 (35%), Gaps = 22/120 (18%) Query: 360 PDCPGELKATAPASPRLGQSQSQADERAGT--------PPPAPPLPPPAPPLP----PPA 407 PD G A PR G+++S A+ T PP P P P +P PP Sbjct: 8897 PDDEGVYSVIARLEPR-GEARSTAELYLTTKEIKLELKPPDIPDSRVPIPTMPIRAVPPE 8955 Query: 408 PPLPPAAPP----LPCAQKAAHPPAGFTKTPK-----SSSPALKPKPNPPSPENTASSAP 458 P APP LP ++ PP T K + KPK P E P Sbjct: 8956 EIPPVVAPPIPLLLPTPEEKKPPPKRIEVTKKAVKKDAKKVVAKPKEMTPREEIVKKPPP 9015 Score = 31.2 bits (69), Expect = 6.1 Identities = 21/61 (34%), Positives = 26/61 (42%), Gaps = 4/61 (6%) Query: 181 PPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPA 240 PP P P PP + A + SPS P P+P AP P PV + +P A Sbjct: 258 PPKPKSRSPTPPSIAAKAQLARQQSPS----PIRHSPSPVRHVRAPTPSPVRSVSPAARI 313 Query: 241 S 241 S Sbjct: 314 S 314 Score = 31.2 bits (69), Expect = 6.1 Identities = 38/163 (23%), Positives = 61/163 (37%), Gaps = 34/163 (20%) Query: 889 PNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPE-PQAPVAWE 947 P VP +PK+ E +P E+P K P + + PE P+ PV E Sbjct: 9297 PEEVAPVP-IPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEE 9355 Query: 948 RVA----------PSNLPQGHP-----------LPKSFSSPPS----PSNKREEEEEEF- 981 ++ P+ +P+ + S PP+ P K EE + Sbjct: 9356 KIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVP 9415 Query: 982 -NFEVIPPPPEFSNDPEPPAPALQY-----LGRQSSPPRNNYS 1018 E +PPPP+ P+ P P + + +++ PPR S Sbjct: 9416 RKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKAPPPRAEVS 9458 Score = 30.8 bits (68), Expect = 8.0 Identities = 24/89 (26%), Positives = 37/89 (41%), Gaps = 11/89 (12%) Query: 139 IPPPPPGPAPGPPQDISEPP-GGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEAL 197 IPP P +P PP ++ PSP +P P + P P P + P + + Sbjct: 257 IPPKPKSRSPTPPSIAAKAQLARQQSPSPIRHSPSPVRHVRAPTPSPVRSVSPAARI-ST 315 Query: 198 SPPHTLSSP---------SIPTPPDFIPP 217 SP ++ SP ++ T P+ PP Sbjct: 316 SPIRSVRSPLLMRKTQASTVATGPEVPPP 344 >gi|150170670 piccolo isoform 2 [Homo sapiens] Length = 4935 Score = 107 bits (267), Expect = 7e-23 Identities = 215/921 (23%), Positives = 315/921 (34%), Gaps = 131/921 (14%) Query: 140 PPPPPGPAPGPPQDISEPPGGSPLPS--PPSTAPPP--PPLLLEPPPPPSMAPPPPPVLE 195 PP PGPA PPQ PG + PS P ST PPP P P P PP Sbjct: 480 PPQQPGPAKPPPQQ----PGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPG 535 Query: 196 ALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPA---PPAPASPHTVGTRLFPP 252 + P SP+ P+ P P PP +P+ PP+ P T+ P Sbjct: 536 SAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTI----CPL 591 Query: 253 GGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRT 312 T+ V T S G NP PHLT + + R Sbjct: 592 CNTTELLLHVPEKANFNTCTECQTTVC------SLCGFNPNPHLTEVKEWLCLNCQMKRA 645 Query: 313 --------SSIPVQEAQEAPRKEEGA-TKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCP 363 S P + + AP A +K +P P P + +APEP P Sbjct: 646 LGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDL--SKAPEPKKP 703 Query: 364 GELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKA 423 L P L S S +A PP A L PAPP P P AP K Sbjct: 704 PPLVK----QPTLHGSPSA---KAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQ 756 Query: 424 AHPPAGFTKTPKSSSPALKP-----KPNPPSPENTASSAPVDWRDPSQM-----EKLRNE 473 T SSS KP K + E T D PSQ EK+ Sbjct: 757 PKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPF 816 Query: 474 LAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLG 533 + + + + +SH PGP+ +SK K+ + +KE K +P + Sbjct: 817 DSKAIPRPASDSKIISH-PGPS--SESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPK 873 Query: 534 GSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKP 593 GS T P T PQ SP P + R L + A K S P P Sbjct: 874 GSP---TPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPK-------SQPTTP 923 Query: 594 R-LEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQ-PKAMLGPAIPPKATPEPAI 651 + G++ GA ++ Q++ L+ T P + GP P K P P+ Sbjct: 924 QETVTGKLFGFGA-----------SIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQ 972 Query: 652 PPKATLWPATPPKATLGPATPLKATSGPT-TPLKATSGPAIASTATTLPTTTSQLMAEKD 710 PP + PPK+T G A P A S P KA + + A P T + EK Sbjct: 973 PPTS----QGPPKST-GQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAP-TVKRTETEKK 1026 Query: 711 SGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVP---- 766 P + ++ + E SP + P ++ K P Sbjct: 1027 PPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPL--CKTELNIGSKDPPNFNTCTECKN 1084 Query: 767 -----CLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTD 821 C + P H + + + + T A G+ ++++ P P+ P AS P Sbjct: 1085 QVCNLCGFNPTPHLTEIQEWLCLNCQT----QRAISGQLGDIRKMPPAPSGPKASPMPV- 1139 Query: 822 ELLRHPVTGEVVERGSPMALLLAARQRAQKG--------RSVGAALGRSSLPGSLRDHSH 873 P + P + L +Q + V L +P + Sbjct: 1140 -----PTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQK 1194 Query: 874 QAEA-----SSDSIFHSQGTPNSFTVVPKLPK-EAEKDSPLTTE-IPNKWGPRLGRDAE- 925 Q E+ + ++ + P ++P+ K +E+ PL E P +L +A+ Sbjct: 1195 QEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKT 1254 Query: 926 GTELSRRHNWTKPEPQAPVAWE----RVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEF 981 ++H+ K + Q +A E RVAP + +G PS + + +E++ Sbjct: 1255 SAPEEQKHDLLKSQVQ--IAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDK 1312 Query: 982 NFEVIPPPPEFSNDPEPPAPA 1002 + I P+PP A Sbjct: 1313 TTKTI------KEQPQPPCTA 1327 Score = 106 bits (264), Expect = 2e-22 Identities = 185/785 (23%), Positives = 263/785 (33%), Gaps = 161/785 (20%) Query: 140 PPPPPGPAPGPPQ-------------DISEPP--------GGSPLPSPPSTAPPPPPLLL 178 PP P GP Q D S P G S PS PS + PP + Sbjct: 251 PPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPP---IQ 307 Query: 179 EPPP--PPSMAP----PPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVP 232 +P P PP+ P P + + P L+ P P PP P PP P+ Sbjct: 308 QPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLG 367 Query: 233 APAPPA-------PASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKG 285 PPA P+S L P GV K A + P + P + G Sbjct: 368 PAKPPAQQTGSEKPSSEQPGPKALAQPPGVGK-----------TPAQQPGPAKPPTQQVG 416 Query: 286 SALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFH 345 + +P L P P TPV+ AQ+A + A + P+ Sbjct: 417 TPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPT--------- 467 Query: 346 IRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLP- 404 +P SQ+ P P PG K P + G ++ + + T PP P P PA P P Sbjct: 468 -KPPSQLPGPAKPPPQQPGPAK---PPPQQPGSAKPPSQQPGSTKPP-PQQPGPAKPSPQ 522 Query: 405 PPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDP 464 P PP+ P A P +S+ P + P T S P Sbjct: 523 QPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVS--------P 574 Query: 465 SQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGK----------KGPRLPEKET 514 S + L +C L H P E + P L E + Sbjct: 575 SAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKE 634 Query: 515 LLSLPAK---------DTPPGVPEKSLGGSSLTETEAA------PSLTLPSVDYIPQD-- 557 L L + P P+ L + +T T A P T P D P+ Sbjct: 635 WLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDL 694 Query: 558 -------SPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKL 610 P P V+Q L S+ A++ + S P P+ E ++ Sbjct: 695 SKAPEPKKPPPLVKQ--PTLHGSPSAKAKQPPEADSLSKPAPPK-------EPSVPSEQD 745 Query: 611 SKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPA----TPPKAT 666 PVA + P Q + PTT L + AT +P IP A TPP T Sbjct: 746 KAPVADDKPKQPKMVKPTTDLVSSS--------SATTKPDIPSSKVQSQAEEKTTPPLKT 797 Query: 667 --LGPATPLKATSGPTTPL--KATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKP-- 720 P+ T +P KA PA S + P +S+ +K P + E+P Sbjct: 798 DSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKK 857 Query: 721 ASQEVSTPSQAR--GEGSPSEATRLPTQGAR---------------------SSAAFPPK 757 A ++S A+ +GSP+ PT G S PK Sbjct: 858 AQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPK 917 Query: 758 TSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGG---AAGPGEPVEVKEPPGLPAKPP 814 + P + K +S+ + + ++ T + G +GPG P +K+ P P++PP Sbjct: 918 SQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAP--MKQAPA-PSQPP 974 Query: 815 ASAQP 819 S P Sbjct: 975 TSQGP 979 Score = 88.6 bits (218), Expect = 3e-17 Identities = 211/1009 (20%), Positives = 319/1009 (31%), Gaps = 139/1009 (13%) Query: 199 PPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKW 258 PP SPS+ + PP PP P PA P + T T + Sbjct: 72 PPAAAESPSMHRKQELDSSHPPKQSGRPPDPG--RPAQPGLSKSRTTDT----------F 119 Query: 259 KSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQ 318 +S+ L GR +S + K L+ + + + + Sbjct: 120 RSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLI 179 Query: 319 EAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRA-PEPDCPGELKATAPASPRLG 377 EA ++E +K + P I+P Q P + P+ PG +P+ Sbjct: 180 SDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPK-- 237 Query: 378 QSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSS 437 SQ E+ + PP P P P LP + A+ P + Sbjct: 238 SISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAK-----LPLQRDASRPQTKQADIVRGE 292 Query: 438 SPALKPKPNPPSPENTASSAPVDWRDPSQM---EKLRNELAAYLCGSRREDRFLSHRPGP 494 S KP+ PSP P + P+Q EK + A + L+ +PG Sbjct: 293 SV----KPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGT 348 Query: 495 TVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTL---PSV 551 P G P PA+ P P GS +E L P V Sbjct: 349 VKPPVQPPGTTKP-----------PAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGV 397 Query: 552 DYIPQDSPTPS---VRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDD 608 P P P+ +Q+ + AK + P + G+I A Sbjct: 398 GKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPG 457 Query: 609 KLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLG 668 K S + P + + LP + P GPA PP P A PP PP G Sbjct: 458 KTS--AQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPG 515 Query: 669 PATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTP 728 PA P G T P G A K S P KP++Q+ + P Sbjct: 516 PAKPSPQQPGSTKPPSQQPGSA------------------KPSAQQPSPAKPSAQQSTKP 557 Query: 729 SQARGEGSPSE-------ATRLPTQGARSSAAFPPKTSPGGGEVP--------------- 766 G G P + A + P+QG + T+ VP Sbjct: 558 VSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTV 617 Query: 767 ---CLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDEL 823 C + P+ H + + + + + G PV P L P + + Sbjct: 618 CSLCGFNPNPHLTEVKEWLC--LNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKS 675 Query: 824 LRHPVTGEVVERGSPMALLLAARQRAQKGRSV------GAALGRSSLPGSLRDHSHQAEA 877 P + +P L A + + V G+ ++ P S A Sbjct: 676 SPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPP 735 Query: 878 SSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRL------GRDAEGTELSR 931 S+ Q PK PK + + L + P + + E T Sbjct: 736 KEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPL 795 Query: 932 RHNWTKPEPQAPVAWERVAPSNLPQGHPLPKSFS---SPPSPSN-----------KREEE 977 + + KP P E+V+P + + P P S S S P PS+ +++EE Sbjct: 796 KTDSAKPSQSFPPTGEKVSPFD-SKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEE 854 Query: 978 EEEFNFEVIPPP---PEFSNDPEPPAP---ALQYLGRQSSPPRNNYSDLRQLPNAG--PG 1029 ++ ++ P P P P PP P A Q + P+ R N G Sbjct: 855 PKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITD 914 Query: 1030 APPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHGGTGRSLSSP 1089 AP + P + G + G G S+ + + PG PH +G +P Sbjct: 915 APKSQ-----PTTPQETVTG---KLFGFGASIFSQASNLISTAGQPG-PHSQSGP--GAP 963 Query: 1090 NCFGPQPGGPEMRR--VNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKA 1136 P P P + S G+APP + + E A A + + KA Sbjct: 964 MKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKA 1012 Score = 63.9 bits (154), Expect = 9e-10 Identities = 79/278 (28%), Positives = 102/278 (36%), Gaps = 77/278 (27%) Query: 347 RPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPP 406 +PASQ+ P +P ++ PA PR S D A PPP PP PPP PP PPP Sbjct: 2371 KPASQL-PSGSPSV-------SSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPP 2422 Query: 407 -APPLPP----------------AAP---------------------------------- 415 PPLPP A+P Sbjct: 2423 PPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTA 2482 Query: 416 PLPCAQKAAHPPAG--FTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNE 473 P P K + P+G FT P+ S P + PKP P T + P D L + Sbjct: 2483 PPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIPQLP-TTTQKPTDIHPKPTGLSLTSS 2541 Query: 474 LAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPR----LPEKETLLSLPAKDTPPGVPE 529 + L S D L P PT K PR L E +++LP++ PG P Sbjct: 2542 MTLNLVTS--ADYKL---PSPTSPLSPHSNKSSPRFSKSLTETYVVITLPSE---PGTPT 2593 Query: 530 KSLGGSSLTETE-AAPSLTLPSVDYIPQDSPTPSVRQI 566 S ++T +PS L SV+ P S P V + Sbjct: 2594 DSSASQAITSWPLGSPSKDLVSVE--PVFSVVPPVTAV 2629 Score = 61.6 bits (148), Expect = 4e-09 Identities = 55/176 (31%), Positives = 65/176 (36%), Gaps = 23/176 (13%) Query: 140 PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPP---PPLLLEPPPPPSMAPPPPPVLEA 196 PPPPP P P PP PP P P PP T+P P P L P + A P + Sbjct: 2407 PPPPPPPPPPPP-----PPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTT 2461 Query: 197 LSPPHTLSSPSIP------TPPDFIPPAPP-----LAFLAPPPPPVP--APAPPAPASPH 243 L L S +P T P +PP P L F P P P AP P P P Sbjct: 2462 LETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIPQLPT 2521 Query: 244 TV--GTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLT 297 T T + P S + LN + + P SP P + P LT Sbjct: 2522 TTQKPTDIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSPLSPHSNKSSPRFSKSLT 2577 Score = 60.1 bits (144), Expect = 1e-08 Identities = 68/269 (25%), Positives = 91/269 (33%), Gaps = 72/269 (26%) Query: 145 GPAPGPPQDISEPPGGSP----LPSPP-----------STAPPPPPLLLEPPPPPSMAPP 189 G G + S+ P GSP LP+ P S PPPPP PPPPP PP Sbjct: 2364 GETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPP 2423 Query: 190 PPPVLEALSPPHTL--------SSPSIPTPPDFIP---------------PAPPLAFLAP 226 PPP+ SP T+ +SP P F P + AP Sbjct: 2424 PPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAP 2483 Query: 227 PP-PPVPAPAP--------PAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPP 277 PP PP P+ P P P+ P + P Q T P Sbjct: 2484 PPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIP----------------QLPTTTQKPT 2527 Query: 278 RSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATK----- 332 +P G +L + +L +K+P P TS + + +PR + T+ Sbjct: 2528 DIHPKPTGLSLTSSMTLNLVTSADYKLPSP----TSPLSPHSNKSSPRFSKSLTETYVVI 2583 Query: 333 KAPSRLPLPPSFHIRPASQVYPDRAPEPD 361 PS P A +P +P D Sbjct: 2584 TLPSEPGTPTDSSASQAITSWPLGSPSKD 2612 Score = 42.7 bits (99), Expect = 0.002 Identities = 81/353 (22%), Positives = 123/353 (34%), Gaps = 60/353 (16%) Query: 567 RNELEARLSSAAEKEA-----KPSIGSLPPKPRLEGGRIC-------ENGADDDKLSKPV 614 + ELEA + ++ E S+ +LP K +L E A P Sbjct: 2323 KKELEAERTKSSLSETVFDHPPSSVIALPMKEQLSTTYFTSGETFGQEKPASQLPSGSPS 2382 Query: 615 AKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKAT--LWPATPPKATLGP--- 669 +LP + ++SL A P PP P P PP L P T PK T+ P Sbjct: 2383 VSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKK 2442 Query: 670 ---------ATPL--KATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSG------ 712 ATPL T+ TT + ++G + TT P + SG Sbjct: 2443 LTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHR 2502 Query: 713 --PAGQP--EKPASQEVSTPSQARGEGSPS----EATRLPTQGARSSAAF--PPKTSPGG 762 P+ P KP ++ T +Q + P T T +SA + P TSP Sbjct: 2503 PEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSP-- 2560 Query: 763 GEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVE-------VKEPPGLPAKPPA 815 PH ++SS ++ + + PG P + P G P+K Sbjct: 2561 ------LSPHSNKSSPRFSKSLTETYVVITLPSEPGTPTDSSASQAITSWPLGSPSKDLV 2614 Query: 816 SAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSL 868 S +P ++ PVT + S ++ + V A + P S+ Sbjct: 2615 SVEPVFSVV-PPVTAVEIPISSEQTFYISGALQTFSATPVTAPSSFQAAPTSV 2666 Score = 32.7 bits (73), Expect = 2.1 Identities = 18/62 (29%), Positives = 26/62 (41%) Query: 121 LYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEP 180 LYS + L PG+ + +P P P PQ + P P+ P TA + +P Sbjct: 3623 LYSPISPLSPGKALESAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDP 3682 Query: 181 PP 182 P Sbjct: 3683 KP 3684 Score = 32.0 bits (71), Expect = 3.6 Identities = 39/147 (26%), Positives = 48/147 (32%), Gaps = 29/147 (19%) Query: 165 SPPSTAPPPPPLL------LEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIP-- 216 SPP P PL L +AP PP + L P + SP F+P Sbjct: 3585 SPPKDKKRPTPLEIGYSSHLRADSTVQLAPSPPKSPKVLYSPISPLSPGKALESAFVPYE 3644 Query: 217 -PAP----PLAFLAPPPPPVPAPAP------------PAPASPHTVGTRLFP----PGGV 255 P P P L P VP +P P P SP + P G Sbjct: 3645 KPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDPKPLSPTADESSRAPFQYTEGYT 3704 Query: 256 TKWKSDVALNGRQAEATRASPPRSPAE 282 TK + +G Q + R P P E Sbjct: 3705 TKGSQTMTSSGAQKKVKRTLPNPPPEE 3731 >gi|150378539 piccolo isoform 1 [Homo sapiens] Length = 5142 Score = 107 bits (267), Expect = 7e-23 Identities = 215/921 (23%), Positives = 315/921 (34%), Gaps = 131/921 (14%) Query: 140 PPPPPGPAPGPPQDISEPPGGSPLPS--PPSTAPPP--PPLLLEPPPPPSMAPPPPPVLE 195 PP PGPA PPQ PG + PS P ST PPP P P P PP Sbjct: 480 PPQQPGPAKPPPQQ----PGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPG 535 Query: 196 ALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPA---PPAPASPHTVGTRLFPP 252 + P SP+ P+ P P PP +P+ PP+ P T+ P Sbjct: 536 SAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTI----CPL 591 Query: 253 GGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRT 312 T+ V T S G NP PHLT + + R Sbjct: 592 CNTTELLLHVPEKANFNTCTECQTTVC------SLCGFNPNPHLTEVKEWLCLNCQMKRA 645 Query: 313 --------SSIPVQEAQEAPRKEEGA-TKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCP 363 S P + + AP A +K +P P P + +APEP P Sbjct: 646 LGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDL--SKAPEPKKP 703 Query: 364 GELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKA 423 L P L S S +A PP A L PAPP P P AP K Sbjct: 704 PPLVK----QPTLHGSPSA---KAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQ 756 Query: 424 AHPPAGFTKTPKSSSPALKP-----KPNPPSPENTASSAPVDWRDPSQM-----EKLRNE 473 T SSS KP K + E T D PSQ EK+ Sbjct: 757 PKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPF 816 Query: 474 LAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLG 533 + + + + +SH PGP+ +SK K+ + +KE K +P + Sbjct: 817 DSKAIPRPASDSKIISH-PGPS--SESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPK 873 Query: 534 GSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKP 593 GS T P T PQ SP P + R L + A K S P P Sbjct: 874 GSP---TPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPK-------SQPTTP 923 Query: 594 R-LEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQ-PKAMLGPAIPPKATPEPAI 651 + G++ GA ++ Q++ L+ T P + GP P K P P+ Sbjct: 924 QETVTGKLFGFGA-----------SIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQ 972 Query: 652 PPKATLWPATPPKATLGPATPLKATSGPT-TPLKATSGPAIASTATTLPTTTSQLMAEKD 710 PP + PPK+T G A P A S P KA + + A P T + EK Sbjct: 973 PPTS----QGPPKST-GQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAP-TVKRTETEKK 1026 Query: 711 SGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVP---- 766 P + ++ + E SP + P ++ K P Sbjct: 1027 PPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPL--CKTELNIGSKDPPNFNTCTECKN 1084 Query: 767 -----CLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTD 821 C + P H + + + + T A G+ ++++ P P+ P AS P Sbjct: 1085 QVCNLCGFNPTPHLTEIQEWLCLNCQT----QRAISGQLGDIRKMPPAPSGPKASPMPV- 1139 Query: 822 ELLRHPVTGEVVERGSPMALLLAARQRAQKG--------RSVGAALGRSSLPGSLRDHSH 873 P + P + L +Q + V L +P + Sbjct: 1140 -----PTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQK 1194 Query: 874 QAEA-----SSDSIFHSQGTPNSFTVVPKLPK-EAEKDSPLTTE-IPNKWGPRLGRDAE- 925 Q E+ + ++ + P ++P+ K +E+ PL E P +L +A+ Sbjct: 1195 QEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKT 1254 Query: 926 GTELSRRHNWTKPEPQAPVAWE----RVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEF 981 ++H+ K + Q +A E RVAP + +G PS + + +E++ Sbjct: 1255 SAPEEQKHDLLKSQVQ--IAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDK 1312 Query: 982 NFEVIPPPPEFSNDPEPPAPA 1002 + I P+PP A Sbjct: 1313 TTKTI------KEQPQPPCTA 1327 Score = 106 bits (264), Expect = 2e-22 Identities = 185/785 (23%), Positives = 263/785 (33%), Gaps = 161/785 (20%) Query: 140 PPPPPGPAPGPPQ-------------DISEPP--------GGSPLPSPPSTAPPPPPLLL 178 PP P GP Q D S P G S PS PS + PP + Sbjct: 251 PPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPP---IQ 307 Query: 179 EPPP--PPSMAP----PPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVP 232 +P P PP+ P P + + P L+ P P PP P PP P+ Sbjct: 308 QPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLG 367 Query: 233 APAPPA-------PASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKG 285 PPA P+S L P GV K A + P + P + G Sbjct: 368 PAKPPAQQTGSEKPSSEQPGPKALAQPPGVGK-----------TPAQQPGPAKPPTQQVG 416 Query: 286 SALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFH 345 + +P L P P TPV+ AQ+A + A + P+ Sbjct: 417 TPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPT--------- 467 Query: 346 IRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLP- 404 +P SQ+ P P PG K P + G ++ + + T PP P P PA P P Sbjct: 468 -KPPSQLPGPAKPPPQQPGPAK---PPPQQPGSAKPPSQQPGSTKPP-PQQPGPAKPSPQ 522 Query: 405 PPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDP 464 P PP+ P A P +S+ P + P T S P Sbjct: 523 QPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVS--------P 574 Query: 465 SQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGK----------KGPRLPEKET 514 S + L +C L H P E + P L E + Sbjct: 575 SAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKE 634 Query: 515 LLSLPAK---------DTPPGVPEKSLGGSSLTETEAA------PSLTLPSVDYIPQD-- 557 L L + P P+ L + +T T A P T P D P+ Sbjct: 635 WLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDL 694 Query: 558 -------SPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKL 610 P P V+Q L S+ A++ + S P P+ E ++ Sbjct: 695 SKAPEPKKPPPLVKQ--PTLHGSPSAKAKQPPEADSLSKPAPPK-------EPSVPSEQD 745 Query: 611 SKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPA----TPPKAT 666 PVA + P Q + PTT L + AT +P IP A TPP T Sbjct: 746 KAPVADDKPKQPKMVKPTTDLVSSS--------SATTKPDIPSSKVQSQAEEKTTPPLKT 797 Query: 667 --LGPATPLKATSGPTTPL--KATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKP-- 720 P+ T +P KA PA S + P +S+ +K P + E+P Sbjct: 798 DSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKK 857 Query: 721 ASQEVSTPSQAR--GEGSPSEATRLPTQGAR---------------------SSAAFPPK 757 A ++S A+ +GSP+ PT G S PK Sbjct: 858 AQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPK 917 Query: 758 TSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGG---AAGPGEPVEVKEPPGLPAKPP 814 + P + K +S+ + + ++ T + G +GPG P +K+ P P++PP Sbjct: 918 SQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAP--MKQAPA-PSQPP 974 Query: 815 ASAQP 819 S P Sbjct: 975 TSQGP 979 Score = 88.6 bits (218), Expect = 3e-17 Identities = 211/1009 (20%), Positives = 319/1009 (31%), Gaps = 139/1009 (13%) Query: 199 PPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKW 258 PP SPS+ + PP PP P PA P + T T + Sbjct: 72 PPAAAESPSMHRKQELDSSHPPKQSGRPPDPG--RPAQPGLSKSRTTDT----------F 119 Query: 259 KSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQ 318 +S+ L GR +S + K L+ + + + + Sbjct: 120 RSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLI 179 Query: 319 EAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRA-PEPDCPGELKATAPASPRLG 377 EA ++E +K + P I+P Q P + P+ PG +P+ Sbjct: 180 SDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPK-- 237 Query: 378 QSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSS 437 SQ E+ + PP P P P LP + A+ P + Sbjct: 238 SISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAK-----LPLQRDASRPQTKQADIVRGE 292 Query: 438 SPALKPKPNPPSPENTASSAPVDWRDPSQM---EKLRNELAAYLCGSRREDRFLSHRPGP 494 S KP+ PSP P + P+Q EK + A + L+ +PG Sbjct: 293 SV----KPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGT 348 Query: 495 TVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTL---PSV 551 P G P PA+ P P GS +E L P V Sbjct: 349 VKPPVQPPGTTKP-----------PAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGV 397 Query: 552 DYIPQDSPTPS---VRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDD 608 P P P+ +Q+ + AK + P + G+I A Sbjct: 398 GKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPG 457 Query: 609 KLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLG 668 K S + P + + LP + P GPA PP P A PP PP G Sbjct: 458 KTS--AQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPG 515 Query: 669 PATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTP 728 PA P G T P G A K S P KP++Q+ + P Sbjct: 516 PAKPSPQQPGSTKPPSQQPGSA------------------KPSAQQPSPAKPSAQQSTKP 557 Query: 729 SQARGEGSPSE-------ATRLPTQGARSSAAFPPKTSPGGGEVP--------------- 766 G G P + A + P+QG + T+ VP Sbjct: 558 VSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTV 617 Query: 767 ---CLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDEL 823 C + P+ H + + + + + G PV P L P + + Sbjct: 618 CSLCGFNPNPHLTEVKEWLC--LNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKS 675 Query: 824 LRHPVTGEVVERGSPMALLLAARQRAQKGRSV------GAALGRSSLPGSLRDHSHQAEA 877 P + +P L A + + V G+ ++ P S A Sbjct: 676 SPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPP 735 Query: 878 SSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRL------GRDAEGTELSR 931 S+ Q PK PK + + L + P + + E T Sbjct: 736 KEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPL 795 Query: 932 RHNWTKPEPQAPVAWERVAPSNLPQGHPLPKSFS---SPPSPSN-----------KREEE 977 + + KP P E+V+P + + P P S S S P PS+ +++EE Sbjct: 796 KTDSAKPSQSFPPTGEKVSPFD-SKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEE 854 Query: 978 EEEFNFEVIPPP---PEFSNDPEPPAP---ALQYLGRQSSPPRNNYSDLRQLPNAG--PG 1029 ++ ++ P P P P PP P A Q + P+ R N G Sbjct: 855 PKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITD 914 Query: 1030 APPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHGGTGRSLSSP 1089 AP + P + G + G G S+ + + PG PH +G +P Sbjct: 915 APKSQ-----PTTPQETVTG---KLFGFGASIFSQASNLISTAGQPG-PHSQSGP--GAP 963 Query: 1090 NCFGPQPGGPEMRR--VNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKA 1136 P P P + S G+APP + + E A A + + KA Sbjct: 964 MKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKA 1012 Score = 63.9 bits (154), Expect = 9e-10 Identities = 79/278 (28%), Positives = 102/278 (36%), Gaps = 77/278 (27%) Query: 347 RPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPP 406 +PASQ+ P +P ++ PA PR S D A PPP PP PPP PP PPP Sbjct: 2371 KPASQL-PSGSPSV-------SSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPP 2422 Query: 407 -APPLPP----------------AAP---------------------------------- 415 PPLPP A+P Sbjct: 2423 PPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTA 2482 Query: 416 PLPCAQKAAHPPAG--FTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNE 473 P P K + P+G FT P+ S P + PKP P T + P D L + Sbjct: 2483 PPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIPQLP-TTTQKPTDIHPKPTGLSLTSS 2541 Query: 474 LAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPR----LPEKETLLSLPAKDTPPGVPE 529 + L S D L P PT K PR L E +++LP++ PG P Sbjct: 2542 MTLNLVTS--ADYKL---PSPTSPLSPHSNKSSPRFSKSLTETYVVITLPSE---PGTPT 2593 Query: 530 KSLGGSSLTETE-AAPSLTLPSVDYIPQDSPTPSVRQI 566 S ++T +PS L SV+ P S P V + Sbjct: 2594 DSSASQAITSWPLGSPSKDLVSVE--PVFSVVPPVTAV 2629 Score = 61.6 bits (148), Expect = 4e-09 Identities = 55/176 (31%), Positives = 65/176 (36%), Gaps = 23/176 (13%) Query: 140 PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPP---PPLLLEPPPPPSMAPPPPPVLEA 196 PPPPP P P PP PP P P PP T+P P P L P + A P + Sbjct: 2407 PPPPPPPPPPPP-----PPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTT 2461 Query: 197 LSPPHTLSSPSIP------TPPDFIPPAPP-----LAFLAPPPPPVP--APAPPAPASPH 243 L L S +P T P +PP P L F P P P AP P P P Sbjct: 2462 LETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIPQLPT 2521 Query: 244 TV--GTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLT 297 T T + P S + LN + + P SP P + P LT Sbjct: 2522 TTQKPTDIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSPLSPHSNKSSPRFSKSLT 2577 Score = 60.1 bits (144), Expect = 1e-08 Identities = 68/269 (25%), Positives = 91/269 (33%), Gaps = 72/269 (26%) Query: 145 GPAPGPPQDISEPPGGSP----LPSPP-----------STAPPPPPLLLEPPPPPSMAPP 189 G G + S+ P GSP LP+ P S PPPPP PPPPP PP Sbjct: 2364 GETFGQEKPASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPP 2423 Query: 190 PPPVLEALSPPHTL--------SSPSIPTPPDFIP---------------PAPPLAFLAP 226 PPP+ SP T+ +SP P F P + AP Sbjct: 2424 PPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAP 2483 Query: 227 PP-PPVPAPAP--------PAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPP 277 PP PP P+ P P P+ P + P Q T P Sbjct: 2484 PPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIP----------------QLPTTTQKPT 2527 Query: 278 RSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATK----- 332 +P G +L + +L +K+P P TS + + +PR + T+ Sbjct: 2528 DIHPKPTGLSLTSSMTLNLVTSADYKLPSP----TSPLSPHSNKSSPRFSKSLTETYVVI 2583 Query: 333 KAPSRLPLPPSFHIRPASQVYPDRAPEPD 361 PS P A +P +P D Sbjct: 2584 TLPSEPGTPTDSSASQAITSWPLGSPSKD 2612 Score = 42.7 bits (99), Expect = 0.002 Identities = 81/353 (22%), Positives = 123/353 (34%), Gaps = 60/353 (16%) Query: 567 RNELEARLSSAAEKEA-----KPSIGSLPPKPRLEGGRIC-------ENGADDDKLSKPV 614 + ELEA + ++ E S+ +LP K +L E A P Sbjct: 2323 KKELEAERTKSSLSETVFDHPPSSVIALPMKEQLSTTYFTSGETFGQEKPASQLPSGSPS 2382 Query: 615 AKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKAT--LWPATPPKATLGP--- 669 +LP + ++SL A P PP P P PP L P T PK T+ P Sbjct: 2383 VSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKK 2442 Query: 670 ---------ATPL--KATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSG------ 712 ATPL T+ TT + ++G + TT P + SG Sbjct: 2443 LTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHR 2502 Query: 713 --PAGQP--EKPASQEVSTPSQARGEGSPS----EATRLPTQGARSSAAF--PPKTSPGG 762 P+ P KP ++ T +Q + P T T +SA + P TSP Sbjct: 2503 PEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSADYKLPSPTSP-- 2560 Query: 763 GEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVE-------VKEPPGLPAKPPA 815 PH ++SS ++ + + PG P + P G P+K Sbjct: 2561 ------LSPHSNKSSPRFSKSLTETYVVITLPSEPGTPTDSSASQAITSWPLGSPSKDLV 2614 Query: 816 SAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSL 868 S +P ++ PVT + S ++ + V A + P S+ Sbjct: 2615 SVEPVFSVV-PPVTAVEIPISSEQTFYISGALQTFSATPVTAPSSFQAAPTSV 2666 Score = 32.7 bits (73), Expect = 2.1 Identities = 18/62 (29%), Positives = 26/62 (41%) Query: 121 LYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEP 180 LYS + L PG+ + +P P P PQ + P P+ P TA + +P Sbjct: 3623 LYSPISPLSPGKALESAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDP 3682 Query: 181 PP 182 P Sbjct: 3683 KP 3684 Score = 32.0 bits (71), Expect = 3.6 Identities = 39/147 (26%), Positives = 48/147 (32%), Gaps = 29/147 (19%) Query: 165 SPPSTAPPPPPLL------LEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIP-- 216 SPP P PL L +AP PP + L P + SP F+P Sbjct: 3585 SPPKDKKRPTPLEIGYSSHLRADSTVQLAPSPPKSPKVLYSPISPLSPGKALESAFVPYE 3644 Query: 217 -PAP----PLAFLAPPPPPVPAPAP------------PAPASPHTVGTRLFP----PGGV 255 P P P L P VP +P P P SP + P G Sbjct: 3645 KPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDPKPLSPTADESSRAPFQYTEGYT 3704 Query: 256 TKWKSDVALNGRQAEATRASPPRSPAE 282 TK + +G Q + R P P E Sbjct: 3705 TKGSQTMTSSGAQKKVKRTLPNPPPEE 3731 >gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [Homo sapiens] Length = 1636 Score = 107 bits (266), Expect = 9e-23 Identities = 111/396 (28%), Positives = 144/396 (36%), Gaps = 47/396 (11%) Query: 126 GDLRPGQY-GQDLLIPPPPPGP-----APGPP--------QDISEPPGGSP----LPSPP 167 G L PG Y G LI P PGP APGP ++ P SP + SP Sbjct: 789 GPLPPGTYSGPTQLIQPRAPGPHAMPVAPGPALYPAPAYTPELGLVPRSSPQHGVVSSPY 848 Query: 168 STAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPP 227 P PP+ P PP P + T+ S P P P P APP Sbjct: 849 VGVGPAPPVAGLPSAPPPQFSGPELAMAVRPATTTVDSIQAPIPSHTAPRPNPTP--APP 906 Query: 228 PPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSA 287 PP P P P +P+T P S G A P P A Sbjct: 907 PPCFPVPPPQPLPTPYTYPAGAKQPIPAQHHFSSGIPAGFPAPRIGPQPQPHPQPHPSQA 966 Query: 288 LGPNP--------EPHLTFPRS-FKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRL 338 GP P PHL P++ +PP +P + P Q P P++ Sbjct: 967 FGPQPPQQPLPLQHPHLFPPQAPGLLPPQSPYPYAPQPGVLGQPPPPLHT-QLYPGPAQD 1025 Query: 339 PLPPSFHIRPASQVYPDRAPEPDCP-GELKATAPASPRLGQSQSQADERAGTPPPAPPL- 396 PLP P P + P P G +T P P+ + AG P+P L Sbjct: 1026 PLPAHSGALPFPSPGPPQPPHPPLAYGPAPSTRPMGPQAAPLTIRGPSSAGQSTPSPHLV 1085 Query: 397 PPPAP-PLPPPAPPLPPAAPPLPCAQKAA----------HPPAGFTKTPKSSSPALKPKP 445 P PAP P P P PP PPAA P PC ++ A G T++P P L+P Sbjct: 1086 PSPAPSPGPGPVPPRPPAAEPPPCLRRGAAAADLLSSSPESQHGGTQSPGGGQPLLQPTK 1145 Query: 446 NPPSPENTASSAPVDWRD----PSQMEKLRNELAAY 477 + + + RD P ++ +L+ EL A+ Sbjct: 1146 VDAAEGRRPQALRLIERDPYEHPERLRQLQQELEAF 1181 Score = 49.7 bits (117), Expect = 2e-05 Identities = 129/560 (23%), Positives = 166/560 (29%), Gaps = 162/560 (28%) Query: 230 PVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPK--GSA 287 P P P P P P + +S+ G E R+ PP A P+ + Sbjct: 716 PPPRPTAPKPLLPR-------------REESEAVEAGDPPEELRSLPPDMVAGPRLPDTF 762 Query: 288 LGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIR 347 LG H PP+P +S+ P P G PLPP + Sbjct: 763 LGSATPLHF---------PPSPFPSSTGP------GPHYLSG---------PLPPGTYSG 798 Query: 348 PASQVYPDRAPEPDC----PGELKATAPA-SPRLGQSQSQADERAGTPPPAPPLPPPAPP 402 P + P RAP P PG APA +P LG + + P + P Sbjct: 799 PTQLIQP-RAPGPHAMPVAPGPALYPAPAYTPELGLVPRSSPQHGVVSSPYVGVGPA--- 854 Query: 403 LPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWR 462 PP LP A PP + S P L P + + AP+ Sbjct: 855 --PPVAGLPSAPPP------------------QFSGPELAMAVRPATTTVDSIQAPI--- 891 Query: 463 DPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKD 522 PS + RP PT AP P P LP Sbjct: 892 -PSHT---------------------APRPNPTPAPPPPCFPVPPPQP-------LPTPY 922 Query: 523 TPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEA 582 T P ++ + + P + PQ P P Q Sbjct: 923 TYPAGAKQPIPAQHHFSSGIPAGFPAPRIGPQPQPHPQPHPSQ----------------- 965 Query: 583 KPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKA----MLG 638 + G PP+ L L P PPQ+ LLP S P A +LG Sbjct: 966 --AFGPQPPQQPLP-------------LQHPHL--FPPQAPGLLPPQSPYPYAPQPGVLG 1008 Query: 639 PAIPPKAT---PEPAIPPKATLWPATP-----------PKATLGPATPLKATSGPTTPLK 684 PP T P PA P A P P GPA P GP Sbjct: 1009 QPPPPLHTQLYPGPAQDPLPAHSGALPFPSPGPPQPPHPPLAYGPA-PSTRPMGPQAAPL 1067 Query: 685 ATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLP 744 GP+ A +T P GP P PA++ P RG + + P Sbjct: 1068 TIRGPSSAGQSTPSPHLVPSPAPSPGPGPV-PPRPPAAE--PPPCLRRGAAAADLLSSSP 1124 Query: 745 TQGARSSAAFPPKTSPGGGE 764 + SPGGG+ Sbjct: 1125 ------ESQHGGTQSPGGGQ 1138 Score = 46.6 bits (109), Expect = 1e-04 Identities = 33/80 (41%), Positives = 38/80 (47%), Gaps = 10/80 (12%) Query: 157 PPGG--SPLPSPPSTAPPP---PPLLLEPPPPPSMAPPP--PPVLEALSPPHTLSSPSIP 209 PPGG SP+ S P A PP P L E P PS +PPP P+ EA P P +P Sbjct: 1509 PPGGLESPVASLPGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEA---PQPKEEPPVP 1565 Query: 210 TPPDFIPPAPPLAFLAPPPP 229 P PP+ L LA P Sbjct: 1566 EAPSSGPPSSSLELLASLTP 1585 Score = 40.8 bits (94), Expect = 0.008 Identities = 107/459 (23%), Positives = 143/459 (31%), Gaps = 92/459 (20%) Query: 442 KPKPNPPSPE----NTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLS-----HRP 492 KP P P +P+ S V+ DP E+LR+ + G R D FL H P Sbjct: 715 KPPPRPTAPKPLLPRREESEAVEAGDPP--EELRSLPPDMVAGPRLPDTFLGSATPLHFP 772 Query: 493 GPTVAPQSK-------EGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPS 545 P+ P S G P T L P P +P G +L AP+ Sbjct: 773 -PSPFPSSTGPGPHYLSGPLPPGTYSGPTQLIQPRAPGPHAMPVAP--GPALYP---APA 826 Query: 546 LTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLP--PKPRLEGGRIC-- 601 T P + +P+ SP V S P + LP P P+ G + Sbjct: 827 YT-PELGLVPRSSPQHGVVS---------SPYVGVGPAPPVAGLPSAPPPQFSGPELAMA 876 Query: 602 --ENGADDDKLSKPVAKNLPPQSTTL---------------LPTTSLQPKAMLGPAIP-- 642 D + P+ + P+ LPT P P IP Sbjct: 877 VRPATTTVDSIQAPIPSHTAPRPNPTPAPPPPCFPVPPPQPLPTPYTYPAGAKQP-IPAQ 935 Query: 643 -------PKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTA 695 P P P I P+ P P GP P + PL A Sbjct: 936 HHFSSGIPAGFPAPRIGPQPQPHPQPHPSQAFGPQPPQQ-------PLPLQHPHLFPPQA 988 Query: 696 TTLPTTTSQLMAEKDSGPAGQPEKPA-SQEVSTPSQARGEGSPSEATRLPTQGARSSAAF 754 L S G GQP P +Q P+Q + P+ + LP F Sbjct: 989 PGLLPPQSPYPYAPQPGVLGQPPPPLHTQLYPGPAQ---DPLPAHSGALP---------F 1036 Query: 755 PPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARG-GAAGPGEPVEVKEPPGLPAKP 813 P P P Y P + + A P RG +AG P P P+ Sbjct: 1037 PSPGPPQPPHPPLAYGPAPSTRPMGPQAA---PLTIRGPSSAGQSTPSPHLVPSPAPSPG 1093 Query: 814 PASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKG 852 P P P + RG+ A LL++ +Q G Sbjct: 1094 PGPVPPRPPAAEPP---PCLRRGAAAADLLSSSPESQHG 1129 Score = 40.4 bits (93), Expect = 0.010 Identities = 28/84 (33%), Positives = 35/84 (41%), Gaps = 6/84 (7%) Query: 137 LLIPPP-----PPGPAPGPPQDISEPPGGSPLPSP-PSTAPPPPPLLLEPPPPPSMAPPP 190 L I PP P PGP + PP P +P PS++PPP L P P PP Sbjct: 1505 LSIRPPGGLESPVASLPGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPV 1564 Query: 191 PPVLEALSPPHTLSSPSIPTPPDF 214 P + P +L + TP F Sbjct: 1565 PEAPSSGPPSSSLELLASLTPEAF 1588 Score = 37.4 bits (85), Expect = 0.086 Identities = 25/71 (35%), Positives = 32/71 (45%), Gaps = 9/71 (12%) Query: 388 GTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNP 447 G P LP PA P P LPPA+ P ++ PP + P+ A +PK P Sbjct: 1512 GLESPVASLPGPAEP-----PGLPPASLPESTPIPSSSPPPLSSPLPE----APQPKEEP 1562 Query: 448 PSPENTASSAP 458 P PE +S P Sbjct: 1563 PVPEAPSSGPP 1573 Score = 34.3 bits (77), Expect = 0.73 Identities = 33/117 (28%), Positives = 45/117 (38%), Gaps = 9/117 (7%) Query: 304 VPPPT-PVRTSSIPVQE--AQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEP 360 VPPP P+ ++SI + Q++ G S IRP + +P Sbjct: 1462 VPPPCKPLASASISQKNHLPQDSQDLVLGGDVPISSIQATIAKLSIRPPGGL---ESPVA 1518 Query: 361 DCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLP-PPAPPLPPPAPPLPPAAPP 416 PG A P P +S + PP + PLP P P PP P P + PP Sbjct: 1519 SLPGP--AEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPVPEAPSSGPP 1573 Score = 33.1 bits (74), Expect = 1.6 Identities = 18/47 (38%), Positives = 24/47 (51%), Gaps = 1/47 (2%) Query: 196 ALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASP 242 ++ PP L SP P PP P A L P P+P+ +PP +SP Sbjct: 1506 SIRPPGGLESPVASLPGPAEPPGLPPASL-PESTPIPSSSPPPLSSP 1551 >gi|146219843 Snf2-related CBP activator protein [Homo sapiens] Length = 3230 Score = 105 bits (262), Expect = 3e-22 Identities = 202/850 (23%), Positives = 275/850 (32%), Gaps = 156/850 (18%) Query: 5 QTVQGTFSKLFGKKHTTTPSTSLYATNPPWIFTQEAPEEGTGGF-------DGIYYGDNR 57 Q + L G TP+ SL T P + AP G+ G + Sbjct: 1084 QVLPSPLGVLSGTSRPPTPTLSLKPTPPAPVRLSPAPPPGSSSLLKPLTVPPGYTFPPAA 1143 Query: 58 FNTVSES-GTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVN 116 T S + TAT A P P L L+ P + EV L + Sbjct: 1144 ATTTSTTTATATTTAVPAPTPAPQRLILS-----------PDMQARLPSGEVVSIGQLAS 1192 Query: 117 GNLRLYSSVGDLRP-------------GQYGQDLLIPPPPPGP-------APGPPQDISE 156 R ++ G +P G + L + P P + G + Sbjct: 1193 LAQRPVANAGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHHLIS 1252 Query: 157 PPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPP----PVLEALSPPHTLSSPSIPTPP 212 P L + P P P+ + P PS P P P+ PP +++ + Sbjct: 1253 QPAHVALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQVPPTMVNNTGVVK-- 1310 Query: 213 DFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEAT 272 + P L P PP PAP PP+ P + R Sbjct: 1311 -IVVRQAPRDGLTPVPPLAPAPRPPSSGLPAVLNPR-----------------------P 1346 Query: 273 RASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIP------VQEAQEAPRK 326 +P R P G+A P P P L P V P+P ++S P + P Sbjct: 1347 TLTPGRLPTPTLGTARAPMPTPTLVRPLLKLVHSPSPEVSASAPGAAPLTISSPLHVPSS 1406 Query: 327 EEGATKKAPSRLPLPPSFHIR---------PASQVYPDRAPEP-DCPGELKATAPASPRL 376 G A S +P+P S + P S P P P T P S L Sbjct: 1407 LPGP---ASSPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTTLPAPASAPLTIPISAPL 1463 Query: 377 GQSQSQADERAGTPPPAPPLPP--PAPPLPPPAPPLPPA---------APPLPCAQKAAH 425 S S PP P+ P P PP P+ P A AP L +Q H Sbjct: 1464 TVSASGPALLTSVTPPLAPVVPAAPGPPSLAPSGASPSASALTLGLATAPSLSSSQTPGH 1523 Query: 426 P----------PAGFTKTPKSSSPALKP-----KPNPPSPENTASSAPVDWRDPSQMEKL 470 P P + + SP L P P P +P + A + S + L Sbjct: 1524 PLLLAPTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAPAQASLLAPASSASQAL 1583 Query: 471 RNELAAYLCGSRREDRFLSHRPGPTVAPQ---SKEGKKGPRLPEKETLLSLPAKDTPPGV 527 LA + + L+ P P +AP + P L +T + + A + PG Sbjct: 1584 ATPLAPM---AAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGT 1640 Query: 528 PEKSLGGSSLTETEAAPSLT---LPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKP 584 S APS T LP+ +P P+P+ Q + A P Sbjct: 1641 SLASASPVPAPTPVLAPSSTQTMLPAP--VPSPLPSPASTQ---------TLALAPALAP 1689 Query: 585 SIGSLPPKPRLEGGRICENGA-DDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPP 643 ++G P L G G LS A +L P T T SL P LGP Sbjct: 1690 TLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPASSLVP---TPAQTLSLAPGPPLGPTQTL 1746 Query: 644 KATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTS 703 P P + P + + PA TL PA+ + P + T PA TL + Sbjct: 1747 SLAPAPPLAPASPVGPAPAHTLTLAPASSSASLLAPASVQTLTLSPA---PVPTLGPAAA 1803 Query: 704 QLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEAT---RLP-------TQGARSSAA 753 Q +A PA + PASQ S A G +P T RLP T RS Sbjct: 1804 QTLA---LAPA-STQSPASQASSLVVSASG-AAPLPVTMVSRLPVSKDEPDTLTLRSGPP 1858 Query: 754 FPPKTSPGGG 763 PP T+ G Sbjct: 1859 SPPSTATSFG 1868 Score = 101 bits (252), Expect = 4e-21 Identities = 201/848 (23%), Positives = 289/848 (34%), Gaps = 124/848 (14%) Query: 134 GQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSP-----PSTAPPPPPLLLEPPPPP--SM 186 G L+ PPGP PP + LPSP ++ PP P L L+P PP + Sbjct: 1057 GPPLIPASRPPGPVLLPPLQPNSGSLPQVLPSPLGVLSGTSRPPTPTLSLKPTPPAPVRL 1116 Query: 187 APPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVG 246 +P PPP +L P T+ P + A P P PAP + Sbjct: 1117 SPAPPPGSSSLLKPLTVPPGYTFPPAAATTTSTTTATATTTAVPAPTPAPQRLILSPDMQ 1176 Query: 247 TRLFPPGGVTKWKSDVALNGRQAEATRASPP-----------RSPAEPKGSALGPNPEP- 294 RL P G V +L R S P + A+ + A+G P P Sbjct: 1177 ARL-PSGEVVSIGQLASLAQRPVANAGGSKPLTFQIQGNKLTLTGAQVRQLAVG-QPRPL 1234 Query: 295 -----HLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHI-RP 348 HL P + I P PS P P + Sbjct: 1235 QRNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLA 1294 Query: 349 ASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPP--- 405 A+QV P + G +K +PR D PP AP PP+ LP Sbjct: 1295 ANQVPPTMV---NNTGVVKIVVRQAPR--------DGLTPVPPLAPAPRPPSSGLPAVLN 1343 Query: 406 PAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTAS---SAPVDWR 462 P P L P P P A P TP P LK + PSPE +AS +AP+ Sbjct: 1344 PRPTLTPGRLPTPTLGTARAP----MPTPTLVRPLLK-LVHSPSPEVSASAPGAAPLTIS 1398 Query: 463 DPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETL-LSLPAK 521 P + A+ S P P +P + +P +L +S+P Sbjct: 1399 SPLHVPSSLPGPAS------------SPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTT 1446 Query: 522 -DTPPGVPEKSLGGSSLTETEAAP----SLTLPSVDYIPQDSPTPSVRQIRNELEARLSS 576 P P + LT + + P S+T P +P PS+ S Sbjct: 1447 LPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSL----------APS 1496 Query: 577 AAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTS--LQPK 634 A A L P L + L P + ++P ++T+ P S L P Sbjct: 1497 GASPSASALTLGLATAPSLSSSQT----PGHPLLLAPTSSHVPGLNSTVAPACSPVLVPA 1552 Query: 635 AMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATS------- 687 + L P + P PA + L PA+ L ATPL + P T + A S Sbjct: 1553 SALASPFP--SAPNPAPAQASLLAPASSASQAL--ATPLAPMAAPQTAILAPSPAPPLAP 1608 Query: 688 ----------GPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSP 737 P +AS+ T +P + + A PA V PS + Sbjct: 1609 LPVLAPSPGAAPVLASSQTPVPVMAPS--STPGTSLASASPVPAPTPVLAPSSTQTMLPA 1666 Query: 738 SEATRLPTQGARSSAAFPPKTSPG-GGEVPCL---------YKPHCHQSSLSREVAVVMP 787 + LP+ + + A P +P GG P P Q+ + ++P Sbjct: 1667 PVPSPLPSPASTQTLALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPASSLVP 1726 Query: 788 TLARGGAAGPGEPVEVKEPPGL-PAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAAR 846 T A+ + PG P+ + L PA P A A P H +T + S +LL A Sbjct: 1727 TPAQTLSLAPGPPLGPTQTLSLAPAPPLAPASPVGPAPAHTLT--LAPASSSASLLAPAS 1784 Query: 847 QRA-----QKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKE 901 + ++G A ++ S ++ASS + S P T+V +LP Sbjct: 1785 VQTLTLSPAPVPTLGPAAAQTLALAPASTQSPASQASSLVVSASGAAPLPVTMVSRLPVS 1844 Query: 902 AEKDSPLT 909 ++ LT Sbjct: 1845 KDEPDTLT 1852 Score = 85.9 bits (211), Expect = 2e-16 Identities = 150/633 (23%), Positives = 211/633 (33%), Gaps = 95/633 (15%) Query: 139 IPPPPPGPAPGPPQDISEPPGGSPLPSP---PSTAPPP----PPLLLEPPPPPSMAPPPP 191 +P P P P P P + P P+P P +AP P P +L PPPPS PP Sbjct: 2436 VPRPAPRPRPTPASAPAAIPALVPVPVSAPVPISAPNPITILPVHILPSPPPPSQIPPCS 2495 Query: 192 PVLEALSPPHTLSSPSIPTPPD----FIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGT 247 A +PP + P TPP + P+ PL L PP P+ A P Sbjct: 2496 S--PACTPPPACTPPPAHTPPPAQTCLVTPSSPL-LLGPPSVPISASVTNLPLGLRP-EA 2551 Query: 248 RLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPP 307 L + ++A ++ + P P + P E +L+ S P Sbjct: 2552 ELCAQALASPESLELASVASSETSSLSLVPPKDLLPVAVEILPVSEKNLSLTPS---APS 2608 Query: 308 TPVRTSSIPVQEAQEAPRKEEGATKKA-PSRLPLPPSFHIRPASQVYPDRAPEPDCPGEL 366 + SIP + QEAP EG T P LP ++ P A + L Sbjct: 2609 LTLEAGSIPNGQEQEAPDSAEGTTLTVLPEGEELPLCVSESNGLELPPSAASDEPLQEPL 2668 Query: 367 KATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHP 426 +A S+ A TP +P P AP +A P A P Sbjct: 2669 EA---------DRTSEELTEAKTPTSSPEKPQELVTAEVAAPSTSSSATSSPEGPSPARP 2719 Query: 427 PAGFTKTPKSSSPALKPKP-NPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRRED 485 P T +P PP P+ V + P ++ + E L RR+ Sbjct: 2720 PRRRTSADVEIRGQGTGRPGQPPGPK-------VLRKLPGRLVTVVEE--KELVRRRRQQ 2770 Query: 486 RFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPS 545 R T+ P E P P + +S P P G P EAAPS Sbjct: 2771 R----GAASTLVPGVSETSASPGSPSVRS-MSGPESSPPIGGP-----------CEAAPS 2814 Query: 546 LTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGR------ 599 +LP+ P P + R I EL + E + PP + GR Sbjct: 2815 SSLPT----PPQQPFIARRHI--ELGVTGGGSPENGDGALLAITPPAVKRRRGRPPKKNR 2868 Query: 600 ---ICENGADDDKLSKPVAKN-----LPPQSTTLLPTTSLQPKAMLGP---AIPPKATPE 648 G D+ S K +P T ++ L+P+ + GP P P Sbjct: 2869 SPADAGRGVDEAPSSTLKGKTNGADPVPGPETLIVADPVLEPQLIPGPQPLGPQPVHRPN 2928 Query: 649 PAIPPKATLWPATPPKATLGPATPLKATSG------------------PTTPLKATSGPA 690 P + P PPKA P +++G P PL Sbjct: 2929 PLLSPVEKRRRGRPPKARDLPIPGTISSAGDGNSESRTQPPPHPSPLTPLPPLLVCPTAT 2988 Query: 691 IASTATTLPTTTSQLMAEKDSGPAGQPEKPASQ 723 +A+T TT+ +TS ++ P P SQ Sbjct: 2989 VANTVTTVTISTSPPKRKRGRPPKNPPSPRPSQ 3021 Score = 70.9 bits (172), Expect = 7e-12 Identities = 144/558 (25%), Positives = 199/558 (35%), Gaps = 81/558 (14%) Query: 305 PPPTPVRTSSIPVQEAQEAPRKEEGATKKAPS--RLPLPPSFHIRPASQVYPDRAPEPDC 362 PPP P + + V + K+EG T + R PL P +RP P+ + +P Sbjct: 983 PPPRP-KPVKMKVNRMLQPVPKQEGRTVVVVNNPRAPLGP-VPVRPPPG--PELSAQPT- 1037 Query: 363 PGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPA-PPLPPPAPPLPPAAPPLPCAQ 421 PG + PAS + S P PPL P + PP P PPL P + LP Q Sbjct: 1038 PGPVPQVLPASLMVSAS-----------PAGPPLIPASRPPGPVLLPPLQPNSGSLP--Q 1084 Query: 422 KAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLR---------- 471 P + T + +P L KP PP+P + + P P L+ Sbjct: 1085 VLPSPLGVLSGTSRPPTPTLSLKPTPPAPVRLSPAPP-----PGSSSLLKPLTVPPGYTF 1139 Query: 472 NELAAYLCGSRREDRFLSHRPGPTVAPQS--KEGKKGPRLPEKETLLSLPAKDTPPGVPE 529 AA + + P PT APQ RLP E ++S+ + P Sbjct: 1140 PPAAATTTSTTTATATTTAVPAPTPAPQRLILSPDMQARLPSGE-VVSIGQLASLAQRPV 1198 Query: 530 KSLGGSS-LTETEAAPSLTL--PSVDYIPQDSPTPSVRQIRNELEA-----RLSSAAEKE 581 + GGS LT LTL V + P P R + + + A +S A Sbjct: 1199 ANAGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHHLISQPAHVA 1258 Query: 582 AKPSIGSLP---PKPRLEGGRICENGADDDKLSKPVAKNLPPQS-----------TTLLP 627 ++ P P L A LS P+A N P + P Sbjct: 1259 LIQAVAPTPGPTPVSVLPSSTPSTTPAPTG-LSLPLAANQVPPTMVNNTGVVKIVVRQAP 1317 Query: 628 TTSLQPKAMLGPAIPPKATPEPAI-PPKATLWPATPPKATLGPA---TPLKATSGPTTPL 683 L P L PA P ++ PA+ P+ TL P P TLG A P P L Sbjct: 1318 RDGLTPVPPLAPAPRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLKL 1377 Query: 684 KATSGPAIASTAT-TLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATR 742 + P ++++A P T S + S P PAS + P+ + S Sbjct: 1378 VHSPSPEVSASAPGAAPLTISSPLHVPSSLPG-----PASSPMPIPNSSPLASPVSSTVS 1432 Query: 743 LPTQGARSSAAFPPKTSPGGGEVPC---LYKPHCHQSSLSREVAVVMPTLARGGAAGPGE 799 +P + + P T P P + P +S + V P LA A PG Sbjct: 1433 VPLSSSLPISV--PTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGP 1490 Query: 800 PVEVKEPPGLPAKPPASA 817 P P G A P ASA Sbjct: 1491 P--SLAPSG--ASPSASA 1504 Score = 60.1 bits (144), Expect = 1e-08 Identities = 145/615 (23%), Positives = 215/615 (34%), Gaps = 128/615 (20%) Query: 348 PASQVYPDRAPEPDCPGELKATAPAS-PRLGQSQSQADERAGTPPPAPPLPPPAPPLPPP 406 PA + P AP P A+APA+ P L A P P LP P PPP Sbjct: 2431 PARERVPRPAPRPR---PTPASAPAAIPALVPVPVSAPVPISAPNPITILPVHILPSPPP 2487 Query: 407 APPLPPAA-----PPLPCAQKAAH-PPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVD 460 +PP + PP C AH PP T SSP L P+ P + ++ P+ Sbjct: 2488 PSQIPPCSSPACTPPPACTPPPAHTPPPAQTCLVTPSSPLLLGPPSVPI-SASVTNLPLG 2546 Query: 461 WRDPSQM--EKLRNELAAYLCG-SRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLS 517 R +++ + L + + L + E LS P + P + E LP E LS Sbjct: 2547 LRPEAELCAQALASPESLELASVASSETSSLSLVPPKDLLPVAVE-----ILPVSEKNLS 2601 Query: 518 LPAKDTPPGVPEKSLGGSSL---TETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARL 574 L P P +L S+ E EA S ++ +P+ P N LE Sbjct: 2602 L-----TPSAPSLTLEAGSIPNGQEQEAPDSAEGTTLTVLPEGEELPLCVSESNGLELPP 2656 Query: 575 SSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPK 634 S+A+++ P + LE R E +L++ P+ L T + Sbjct: 2657 SAASDE---------PLQEPLEADRTSE------ELTEAKTPTSSPEKPQELVTAEVAAP 2701 Query: 635 AMLGPAIPPKATPEPAIPPK------------ATLWPATPPKATLGPATPLKATSGPTTP 682 + A P PA PP+ T P PP GP K T Sbjct: 2702 STSSSATSSPEGPSPARPPRRRTSADVEIRGQGTGRPGQPP----GPKVLRKLPGRLVTV 2757 Query: 683 LK---------------ATSGPAIASTATTLPTTTSQLMAEKDSGP--AGQPEKPASQEV 725 ++ +T P ++ T+ + + + + M+ +S P G E S + Sbjct: 2758 VEEKELVRRRRQQRGAASTLVPGVSETSASPGSPSVRSMSGPESSPPIGGPCEAAPSSSL 2817 Query: 726 STPSQ------------ARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHC 773 TP Q G GSP GA A PP G P K + Sbjct: 2818 PTPPQQPFIARRHIELGVTGGGSPENG-----DGA-LLAITPPAVKRRRGRPP---KKNR 2868 Query: 774 HQSSLSREVAVVMPTLARGGAAGPGEPV----------EVKEPPGLPAKPPASAQPTDEL 823 + R V + +G G +PV V EP +P P QP Sbjct: 2869 SPADAGRGVDEAPSSTLKGKTNG-ADPVPGPETLIVADPVLEPQLIPGPQPLGPQP---- 2923 Query: 824 LRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIF 883 V R +P LL+ ++ ++GR A +PG++ S + +S+S Sbjct: 2924 ---------VHRPNP---LLSPVEKRRRGRPPKAR--DLPIPGTI---SSAGDGNSESRT 2966 Query: 884 HSQGTPNSFTVVPKL 898 P+ T +P L Sbjct: 2967 QPPPHPSPLTPLPPL 2981 Score = 59.3 bits (142), Expect = 2e-08 Identities = 80/285 (28%), Positives = 99/285 (34%), Gaps = 57/285 (20%) Query: 139 IPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALS 198 +P P P AP Q + P SPLPSP ST ++AP P L S Sbjct: 1648 VPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTL------------ALAPALAPTLGGSS 1695 Query: 199 PPHTLS----SPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGG 254 P TLS +P P P + L P VP PA +P PP G Sbjct: 1696 PSQTLSLGTGNPQGPFPTQTLS-------LTPASSLVPTPAQTLSLAPG-------PPLG 1741 Query: 255 VTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTF-PRSFKVPPPTPVRTS 313 T Q + +PP +PA P +GP P LT P S P + Sbjct: 1742 PT-----------QTLSLAPAPPLAPASP----VGPAPAHTLTLAPASSSASLLAP---A 1783 Query: 314 SIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPAS 373 S+ AP G A L L P+ PASQ + G Sbjct: 1784 SVQTLTLSPAPVPTLGPA--AAQTLALAPASTQSPASQA---SSLVVSASGAAPLPVTMV 1838 Query: 374 PRLGQSQSQADE---RAGTPPPAPPLPPPAPPLPPPAPPLPPAAP 415 RL S+ + D R+G P P P P PP PP +P Sbjct: 1839 SRLPVSKDEPDTLTLRSGPPSPPSTATSFGGPRPRRQPPPPPRSP 1883 Score = 54.7 bits (130), Expect = 5e-07 Identities = 120/529 (22%), Positives = 174/529 (32%), Gaps = 87/529 (16%) Query: 264 LNGRQAEATRASPPRSPAEPKGSALGPNPEP-HLTFPRSFKVPPPTPVRTSSIPVQEAQE 322 ++ Q +T P SPA + P P P + P + P PV S PV + Sbjct: 2415 ISAHQTRSTTTPPRCSPARERVPRPAPRPRPTPASAPAAIPALVPVPV---SAPVPISAP 2471 Query: 323 APRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQ 382 P T LP PP P SQ+ P P C T P Sbjct: 2472 NP-----ITILPVHILPSPP-----PPSQIPP--CSSPACTPPPACTPPP---------- 2509 Query: 383 ADERAGTPPPAPP-LPPPAPP--LPPPAPPLPPAAPPLP---------CAQKAAHPP--- 427 A TPPPA L P+ P L PP+ P+ + LP CAQ A P Sbjct: 2510 ----AHTPPPAQTCLVTPSSPLLLGPPSVPISASVTNLPLGLRPEAELCAQALASPESLE 2565 Query: 428 -AGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDR 486 A + SS + PK P + + L E + G +E Sbjct: 2566 LASVASSETSSLSLVPPKDLLPVAVEILPVSEKNLSLTPSAPSLTLEAGSIPNGQEQE-- 2623 Query: 487 FLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTE-TEAAPS 545 AP S EG LPE E L ++ +P + L E EA + Sbjct: 2624 ----------APDSAEGTTLTVLPEGEELPLCVSESNGLELPPSAASDEPLQEPLEADRT 2673 Query: 546 LTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGA 605 + P SP + E+ A +S++ + P R + G Sbjct: 2674 SEELTEAKTPTSSPEKPQELVTAEVAAPSTSSSATSSPEGPSPARPPRRRTSADVEIRGQ 2733 Query: 606 DDDKLSKP----VAKNLPPQSTTLLPTTSL--QPKAMLGPAIPPKATPEPAIPPKATLWP 659 + +P V + LP + T++ L + + G A +TL P Sbjct: 2734 GTGRPGQPPGPKVLRKLPGRLVTVVEEKELVRRRRQQRGAA--------------STLVP 2779 Query: 660 ATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLM-----AEKDSGPA 714 + + +++ SGP + GP A+ +++LPT Q E Sbjct: 2780 GVSETSASPGSPSVRSMSGPESS-PPIGGPCEAAPSSSLPTPPQQPFIARRHIELGVTGG 2838 Query: 715 GQPEK--PASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPG 761 G PE A ++ P+ R G P + R P R P T G Sbjct: 2839 GSPENGDGALLAITPPAVKRRRGRPPKKNRSPADAGRGVDEAPSSTLKG 2887 Score = 52.0 bits (123), Expect = 3e-06 Identities = 135/615 (21%), Positives = 196/615 (31%), Gaps = 148/615 (24%) Query: 82 LPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLRLYSSVGDLRPGQYGQDLLIPP 141 LPL E++GL +P + D+ + + + + L Sbjct: 2642 LPLCVSESNGLELPPSAASDEPLQEPLEADRT---------------------SEELTEA 2680 Query: 142 PPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMA-------------- 187 P +P PQ++ +P S +T+ P P PP + A Sbjct: 2681 KTPTSSPEKPQELVTAEVAAPSTSSSATSSPEGPSPARPPRRRTSADVEIRGQGTGRPGQ 2740 Query: 188 PPPPPVLEAL-----------------------------SPPHTLSSPSIPTPPDFIPP- 217 PP P VL L T +SP P+ P Sbjct: 2741 PPGPKVLRKLPGRLVTVVEEKELVRRRRQQRGAASTLVPGVSETSASPGSPSVRSMSGPE 2800 Query: 218 -APPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSD---VALNGRQAEATR 273 +PP+ P P PP L GG + D +A+ + R Sbjct: 2801 SSPPIGGPCEAAPSSSLPTPPQQPFIARRHIELGVTGGGSPENGDGALLAITPPAVKRRR 2860 Query: 274 ASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSI---PVQEAQEAPRKEEGA 330 PP+ P + G + P T P P + I PV E Q P + Sbjct: 2861 GRPPKKNRSPADAGRGVDEAPSSTLKGKTNGADPVPGPETLIVADPVLEPQLIPGPQPLG 2920 Query: 331 TKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTP 390 + P P P + + P +A + PG + + G S+S+ T Sbjct: 2921 PQ--PVHRPNPLLSPVEKRRRGRPPKARDLPIPGTISSAGD-----GNSESR------TQ 2967 Query: 391 PPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALK---PKPNP 447 P PP P P PL PPL A T T +S P K P NP Sbjct: 2968 P--PPHPSPLTPL-----------PPLLVCPTATVANTVTTVTISTSPPKRKRGRPPKNP 3014 Query: 448 PSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGP 507 PSP S PV RD + + L + G RR+ + G + S + G Sbjct: 3015 PSPR--PSQLPVLDRDSTSV------LESCGLGRRRQPQ------GQGESEGSSSDEDGS 3060 Query: 508 RLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIR 567 R + L L A+ G+ + GGS + V I+ Sbjct: 3061 RPLTRLARLRLEAE----GMRGRKSGGSMV-------------------------VAVIQ 3091 Query: 568 NELEARLSSAAEKEAKPSIGSLPPK---PRLEGGRICENGADDDKLSKPVAKNLPPQSTT 624 ++L+ S E P + SL PK RL G + + +KL + A S Sbjct: 3092 DDLDLADSGPGGLELTPPVVSLTPKLRSTRLRPGSLVP-PLETEKLPRKRAGAPVGGSPG 3150 Query: 625 LLPTTSLQPKAMLGP 639 L LQP + LGP Sbjct: 3151 LAKRGRLQPPSPLGP 3165 Score = 42.0 bits (97), Expect = 0.003 Identities = 115/495 (23%), Positives = 164/495 (33%), Gaps = 104/495 (21%) Query: 711 SGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYK 770 S A PE+P ++ AR E + T + + S PP+ SP VP Sbjct: 2382 SKKAKAPERPGTRVSERLRGARAETQGANHTPVISAHQTRSTTTPPRCSPARERVP---- 2437 Query: 771 PHCHQSSLSREVAVVMPTLARGGAAGPG-EPVEVKEPPGLPAKPPASAQPTDELLRHPVT 829 R PT A AA P PV V P + A P + P L P Sbjct: 2438 ---------RPAPRPRPTPASAPAAIPALVPVPVSAPVPISAPNPITILPVHILPSPPPP 2488 Query: 830 GEVVERGSP--------------------MALLLAARQRAQKGRSVGAALGRSSLPGSLR 869 ++ SP L+ + SV + ++LP LR Sbjct: 2489 SQIPPCSSPACTPPPACTPPPAHTPPPAQTCLVTPSSPLLLGPPSVPISASVTNLPLGLR 2548 Query: 870 DHSH---QAEASSDSI---FHSQGTPNSFTVVPKLPKEAEKDSPLTTEI--PNKWGPRLG 921 + QA AS +S+ + +S ++VP PK+ P+ EI ++ L Sbjct: 2549 PEAELCAQALASPESLELASVASSETSSLSLVP--PKDL---LPVAVEILPVSEKNLSLT 2603 Query: 922 RDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPLPKSFSS------PPS------ 969 A L E +AP + E + LP+G LP S PPS Sbjct: 2604 PSAPSLTLEAGSIPNGQEQEAPDSAEGTTLTVLPEGEELPLCVSESNGLELPPSAASDEP 2663 Query: 970 -------------------PSNKREEEEEEFNFEVIPPPPEFS--NDPEPPAPALQYLGR 1008 P++ E+ +E EV P S + PE P+PA Sbjct: 2664 LQEPLEADRTSEELTEAKTPTSSPEKPQELVTAEVAAPSTSSSATSSPEGPSPA------ 2717 Query: 1009 QSSPPRNNYS---DLRQLPNAGPGAPPALGFSRFPAGARYAGAGGLE------RFSGGGR 1059 PPR S ++R PG PP R G E + G Sbjct: 2718 --RPPRRRTSADVEIRGQGTGRPGQPPGPKVLRKLPGRLVTVVEEKELVRRRRQQRGAAS 2775 Query: 1060 SLIKKRLYVGEPHRGPGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPR 1119 +L+ V E PG P + RS+S P P GGP +S+ PP R Sbjct: 2776 TLVPG---VSETSASPGSP---SVRSMSGPES-SPPIGGPCEAAPSSSLPTPPQQPFIAR 2828 Query: 1120 LSLEGAARGAAEAKH 1134 +E G ++ Sbjct: 2829 RHIELGVTGGGSPEN 2843 Score = 32.0 bits (71), Expect = 3.6 Identities = 37/148 (25%), Positives = 56/148 (37%), Gaps = 25/148 (16%) Query: 679 PTTPLKATSGPAI-ASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSP 737 P T KA S P + +S+A + P + + ++D Q ++ E + + + EG+ Sbjct: 254 PLTSSKAGSSPCLGSSSAASSPPPPASRLDDEDGDFQPQEDEEEDDEETIEVEEQQEGND 313 Query: 738 SEATRLPTQGARSSAAFP--------PKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTL 789 +EA R + R P P G P P H S +R+ Sbjct: 314 AEAQRREIELLRREGELPLEELLRSLPPQLLEGPSSPS-QTPSSHDSD-TRD-------- 363 Query: 790 ARGGAAGPGEPVEVKEPPGLPAKPPASA 817 GP E E + P L KPP SA Sbjct: 364 ------GPEEGAEEEPPQVLEIKPPPSA 385 Score = 30.8 bits (68), Expect = 8.0 Identities = 37/150 (24%), Positives = 51/150 (34%), Gaps = 13/150 (8%) Query: 83 PLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLRLYSSVGDLRPGQYGQDLLIPPP 142 PL + LA P P T +L + SS L P L P P Sbjct: 1739 PLGPTQTLSLAPAPPLAPASPVGPAPAHTLTLAPAS----SSASLLAPASVQTLTLSPAP 1794 Query: 143 PPGPAPGPPQDISEPPGGSPLPSPPSTA-------PPPPPLLLEPPPPPSMAPPPPPVLE 195 P P Q ++ P + P+ +++ P P+ + P S P L Sbjct: 1795 VPTLGPAAAQTLALAPASTQSPASQASSLVVSASGAAPLPVTMVSRLPVSKDEPDTLTLR 1854 Query: 196 A--LSPPHTLSSPSIPTPPDFIPPAPPLAF 223 + SPP T +S P P PP P F Sbjct: 1855 SGPPSPPSTATSFGGPRPRRQPPPPPRSPF 1884 >gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens] Length = 816 Score = 103 bits (257), Expect = 1e-21 Identities = 118/456 (25%), Positives = 168/456 (36%), Gaps = 73/456 (16%) Query: 134 GQDLLIPPPPPGPAPGPPQD------ISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMA 187 G ++ +P P P P PP + S + PSP + P L+ P S++ Sbjct: 175 GTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLS 234 Query: 188 PPPPPVLE-ALSPPHTLSSPSIPT--------------PPDFIPP----APPLAFLAPPP 228 P+ A S P +P P PP PP AP L L+ P Sbjct: 235 SSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSP 294 Query: 229 PPVPAP-APPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSA 287 P+P APP+P++P ++ T PP ++ +L +AT + P P P + Sbjct: 295 LATPSPSAPPSPSAPPSLQTLPSPPATPPS-QATTSLGSPTLQATHSFLPSPPLSPLATP 353 Query: 288 LGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIR 347 PP P + P+Q AP + +P P P + + Sbjct: 354 -----------------PPQAPPALALPPLQ----APPSPPASPPLSPLATPSPQAPNAL 392 Query: 348 PASQVYPDRAPEPDCPGELKATAPASPRLGQSQ---SQADERAGTPP-PAPPLPPPAPPL 403 + +P P P + + PASP + S SQA PP PP PP +PP+ Sbjct: 393 AVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPM 452 Query: 404 PPPAPPLPPAAPPL--PCAQKAAHPPAGFTKTPKSSSPALKPKPNPP---------SPEN 452 P A P P A PPL P Q A PP P ++P L+ P+PP SP Sbjct: 453 SPSATPPPQAPPPLAAPPLQLAKPPPQA---PPALATPPLQALPSPPASFPGQAPFSPSA 509 Query: 453 TASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEK 512 + +P+ P L L + R PT P + GPRL Sbjct: 510 SLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDT--SVSGPRL--- 564 Query: 513 ETLLSLPAKDTPPG-VPEKSLGGSSLTETEAAPSLT 547 TL P PP P +L G L ++ + T Sbjct: 565 -TLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATST 599 Score = 99.8 bits (247), Expect = 1e-20 Identities = 199/797 (24%), Positives = 262/797 (32%), Gaps = 189/797 (23%) Query: 130 PGQYGQDLLIPPPPPGPAPGPP-----------------QDISEPPGGSPLPSPPSTAPP 172 P LL P PP P P PP + ++E GG + P +AP Sbjct: 17 PAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPR 76 Query: 173 PPPLLLEPPP--------PPSMAPPPPPVLE------------------ALSPPHTLS-- 204 P PP PP+ P PV +S T++ Sbjct: 77 AGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARG 136 Query: 205 -----------------SPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGT 247 S PTP P + A +P PAP A P T G Sbjct: 137 KATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGP 196 Query: 248 R----------LFPPGGVTKWKSDVALNGRQAEATR-----ASPPRSPAEPKGSALG-PN 291 R P + + A G Q A+R A+P SPA SA G P Sbjct: 197 RKSVSSASEHSTTEPSPAAR-RRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPR 255 Query: 292 PEPHLTFPR-----SFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHI 346 H + P+ + + P TP R + P P +PS PPS Sbjct: 256 APAHPSQPKPKGLQALRPPQVTPPRKDAAPAL----GPLSSSPLATPSPS---APPSPSA 308 Query: 347 RPASQVYPDRAPEPDCPGELKATAPASPRLGQSQS-----QADERAGTPPPAPP---LPP 398 P+ Q P P P T+ SP L + S A PP APP LPP Sbjct: 309 PPSLQTLPS---PPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPP 365 Query: 399 -PAPPLPPPAPPLPPAAPPLPCAQKA----------AHPPAGFTKTPKS--SSPALKPKP 445 APP PP +PPL P A P P A A + PP+ + P S +SP + P Sbjct: 366 LQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSA 425 Query: 446 NPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKK 505 PPS + +AP PS +A P P AP + K Sbjct: 426 TPPSQAPPSLAAPPLQVPPSPPASPPMSPSA---------TPPPQAPPPLAAPPLQLAKP 476 Query: 506 GPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQ 565 P+ P PA TPP S S + +PS +LP P +P P Sbjct: 477 PPQAP--------PALATPPLQALPSPPASFPGQAPFSPSASLP---MSPLATPPPQAPP 525 Query: 566 IRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKP----VAKNLPPQ 621 + L A L S P P L+ R D +S P PP Sbjct: 526 V---LAAPLLQVPP--------SPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPP 574 Query: 622 STTLLPTTSLQPKAMLGPAIPPKATPE--------------PAIPPKATLWPATPPKATL 667 + P+++L + G + +TPE + PP A L P + Sbjct: 575 PPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSR 634 Query: 668 GPATPLKATSGPTTPL--KATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEV 725 GPA PL P PL +GP A T+ T GP E Sbjct: 635 GPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYET---------EGP----------ES 675 Query: 726 STPSQARGEGSPSEATR--LPTQGARSSAAFPPKTSPGGGEVPC-LYKPHCHQSSLSREV 782 +TP+ + PS T GA + A+ GE+P + Q LSR + Sbjct: 676 ATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLSRTL 735 Query: 783 AVVMPTLARGGA-AGPG 798 + A GG+ GPG Sbjct: 736 LLAAAEGAAGGSGGGPG 752 Score = 97.1 bits (240), Expect = 9e-20 Identities = 134/489 (27%), Positives = 174/489 (35%), Gaps = 59/489 (12%) Query: 129 RPGQYGQDLLIPPP--PP----GPAPGPPQDISEPPGGSPLPS-------PPSTAPPPPP 175 +P G L PP PP PA GP +S P +P PS PPS P P Sbjct: 262 QPKPKGLQALRPPQVTPPRKDAAPALGP---LSSSPLATPSPSAPPSPSAPPSLQTLPSP 318 Query: 176 LLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPA 235 P PPS A +L SP++ F+ P+PPL+ LA PPP P PA Sbjct: 319 ----PATPPSQATT------------SLGSPTLQATHSFL-PSPPLSPLATPPPQAP-PA 360 Query: 236 ---PPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAE-----PKGSA 287 PP A P + P ++ AL +A + PP P + P Sbjct: 361 LALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPP 420 Query: 288 LGPNPEPHLTFPRSFKVPP--PTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFH 345 + P+ P P S PP P +S P+ + P + P +L PP Sbjct: 421 VSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPP-- 478 Query: 346 IRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPP 405 P + P P P AP SP S S TPPP P AP L Sbjct: 479 QAPPALATPPLQALPSPPASFPGQAPFSP----SASLPMSPLATPPPQAPPVLAAPLL-- 532 Query: 406 PAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPP---SPENTASSAPVDWR 462 PP PPA+P L ++ P + + + AL P P PP SP +T S + Sbjct: 533 QVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGH 592 Query: 463 DPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLP-EKETLLSLPAK 521 S EL Y G A +GP P P Sbjct: 593 S-SSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLP 651 Query: 522 DTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKE 581 P P + G ++ ETE S T P SP S + A SS + K+ Sbjct: 652 WPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQ 711 Query: 582 AKPSIGSLP 590 A+ +G LP Sbjct: 712 AR--LGELP 718 Score = 92.4 bits (228), Expect = 2e-18 Identities = 190/719 (26%), Positives = 247/719 (34%), Gaps = 121/719 (16%) Query: 146 PAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSS 205 PA P ++ P GSP P PP T P L P A Sbjct: 17 PAARAPGLLTPRPPGSPRPPPPVT-----PAALRVLGAAGAVGRKPLAERAGGIGGATIP 71 Query: 206 PSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVG--TRLFPPG--GVTKWKSD 261 S P PP + PP +P +SP TR P G G+ + Sbjct: 72 ESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEE 131 Query: 262 VALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQ 321 G+ EA + S + A S GP P P P R S Sbjct: 132 TVARGKATEAPKRSALSAGARRDTS--GPTP----------GTPSPAMARRS-------- 171 Query: 322 EAPRKEEGATKKAPSRLPLPPSFHIRPA-SQVYPDRAPEPDCPGELKATA------PASP 374 A E G + APS P PP+ R + S EP + +A PAS Sbjct: 172 RAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASR 231 Query: 375 RLGQSQSQADERAGTPPPAPPLP-PPAPPLPPPAPPLPPAAPP-LPCAQKAAHPPAGFTK 432 L S + A + P A P PA P P L PP + +K A P G Sbjct: 232 SLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALG--- 288 Query: 433 TPKSSSPALKPKPN-PPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHR 491 P SSSP P P+ PPSP SAP + A GS S Sbjct: 289 -PLSSSPLATPSPSAPPSP-----SAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFL 342 Query: 492 PGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSV 551 P P ++P + P+ P L L A +PP P S + + A ++ L Sbjct: 343 PSPPLSPLA---TPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQA 399 Query: 552 DYIPQDSPTPSVRQIRNELEARLSSAA--EKEAKPSIGS----LPPKPRLEGGRICENGA 605 + P SP P +S +A +A PS+ + +PP P + + Sbjct: 400 PFSPPPSP-PVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPP-ASPPMSPSAT 457 Query: 606 DDDKLSKPVA------KNLPPQSTTLLPTTSLQ-----PKAMLGPA---------IPPKA 645 + P+A PPQ+ L T LQ P + G A + P A Sbjct: 458 PPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLA 517 Query: 646 TPEPAIPPKATL----WPATPPKATLGPATPLKATSGPTTPLKATSGPAIA-STATTLPT 700 TP P PP P +PP + A T GP T + SGP + + A P Sbjct: 518 TPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDT---SVSGPRLTLALAPGPPP 574 Query: 701 TTSQLMAEKDSGP--AGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKT 758 S+ + SGP AG +S STP + RG S E +AA PP Sbjct: 575 PPSRSPSSTLSGPDLAGH----SSSATSTPEELRGYDSGPEG---------GAAASPP-- 619 Query: 759 SPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASA 817 P CH ++ SR A P LA GA PG P+ P PA P SA Sbjct: 620 -------PDAELAACHPAAWSRGPA---PPLAFRGA--PGAPL-----PWPPATGPGSA 661 Score = 72.4 bits (176), Expect = 2e-12 Identities = 206/875 (23%), Positives = 279/875 (31%), Gaps = 187/875 (21%) Query: 356 RAPEPDCPGELKATAPASPR------------LGQS----QSQADERAGTPPPAPPLPPP 399 R P PG L P SPR LG + + ERAG A +P Sbjct: 15 RTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGAT-IPES 73 Query: 400 APPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPV 459 AP P PPA+ A A + G +P +S +P P ++ V Sbjct: 74 APRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETV 133 Query: 460 DWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLP 519 ++ K R+ L+A G+RR+ GPT S + R E L P Sbjct: 134 ARGKATEAPK-RSALSA---GARRDTS------GPTPGTPSPAMARRSRAAGTEVGLPRP 183 Query: 520 AKDTPPGVP----EKSLGGSSL-TETEAAPSLTL-PSVDYIPQDSPTPSVRQIRNELEAR 573 A P P KS+ +S + TE +P+ PS Q + S+ L + Sbjct: 184 APSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSP 243 Query: 574 LSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQP 633 S P + P +P+ +G + PPQ T P P Sbjct: 244 ARSGPSARGTPRAPAHPSQPKPKGLQALR----------------PPQVTP--PRKDAAP 285 Query: 634 KAMLGP-AIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATS----- 687 LGP + P ATP P+ PP P+ PP P+ P S TT L + + Sbjct: 286 A--LGPLSSSPLATPSPSAPPS----PSAPPSLQTLPSPPATPPSQATTSLGSPTLQATH 339 Query: 688 ----GPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRL 743 P ++ AT P L P P P ++TPS P L Sbjct: 340 SFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPS-------PQAPNAL 392 Query: 744 PTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEV 803 ++ + PP P + P +S + P+ A A P P++V Sbjct: 393 AVHLLQAPFSPPPS--------PPVQAPFSPPASPPVSPSATPPSQAPPSLAAP--PLQV 442 Query: 804 KEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSS 863 PP PA PP S T +P L Q A+ AL Sbjct: 443 --PPSPPASPPMSPSATPP------------PQAPPPLAAPPLQLAKPPPQAPPALATPP 488 Query: 864 LPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRD 923 L QA S + F Q P P + SPL T Sbjct: 489 L---------QALPSPPASFPGQA--------PFSPSASLPMSPLAT------------- 518 Query: 924 AEGTELSRRHNWTKPEPQAPVAWE----RVAPSNLPQGHPLPKSFSSPPSPSNKREEEEE 979 P PQAP +V PS P P ++ PP+P Sbjct: 519 --------------PPPQAPPVLAAPLLQVPPS--PPASPTLQAPRRPPTPGPDTSVSGP 562 Query: 980 EFNFEVIP-PPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLRQL---PNAGPGAPPA-- 1033 + P PPP S P G SS + +LR P G A P Sbjct: 563 RLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSAT-STPEELRGYDSGPEGGAAASPPPD 621 Query: 1034 --------LGFSRFPAGA-RYAGAGGLER----FSGGGRSLIKKRLYVGE------PHRG 1074 +SR PA + GA G +G G + +Y E P G Sbjct: 622 AELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPG 681 Query: 1075 ---PGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAP-------RLSLEG 1124 PG G +G ++ G P+ R+ G P G L A R L Sbjct: 682 ALDPGPSPGTSGGKAAAGAGAGASSRSPKQARL---GELPLGALQASVVQHLLSRTLLLA 738 Query: 1125 AARGAAEAKHKAPGSADYGFAPAAGRSPYTTTRYG 1159 AA GAA PG A+ G R+ + G Sbjct: 739 AAEGAAGGSGGGPGGAEGGGVTGGARAALSDAELG 773 Score = 71.6 bits (174), Expect = 4e-12 Identities = 123/522 (23%), Positives = 169/522 (32%), Gaps = 97/522 (18%) Query: 376 LGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPK 435 + + +A A PA P P PP +P PP P P A + + P Sbjct: 1 MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPP--PVTPAALRVLGAAGAVGRKPL 58 Query: 436 SS-----SPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSH 490 + A P+ P + S P R + +N + R + Sbjct: 59 AERAGGIGGATIPESAPRAGPTRTSRPPASGRG-ERAPPAKNTSPGPVSSPGRASG--TT 115 Query: 491 RPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTP-----------------PGVPEKSLG 533 RPGP G+KG R+ +ET+ A + P PG P ++ Sbjct: 116 RPGPL-------GQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMA 168 Query: 534 -GSSLTETEAAPSLTLPSV-DYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPP 591 S TE PS P + P SV S AA + +PS G Sbjct: 169 RRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARR--RPSAGGGLQ 226 Query: 592 KPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPK----------------- 634 +P R + A LS P + T P QPK Sbjct: 227 RP---ASRSLSSSA--TPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRK 281 Query: 635 ---AMLGP-AIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATS--- 687 LGP + P ATP P+ PP P+ PP P+ P S TT L + + Sbjct: 282 DAAPALGPLSSSPLATPSPSAPPS----PSAPPSLQTLPSPPATPPSQATTSLGSPTLQA 337 Query: 688 ------GPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPS------------ 729 P ++ AT P L P P P ++TPS Sbjct: 338 THSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLL 397 Query: 730 QARGEGSPSEATRL----PTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVV 785 QA PS + P S +A PP +P P L P +S + Sbjct: 398 QAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSAT 457 Query: 786 MPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHP 827 P A A P P+++ +PP P PPA A P + L P Sbjct: 458 PPPQAPPPLAAP--PLQLAKPP--PQAPPALATPPLQALPSP 495 >gi|122937496 WAS/WASL interacting protein family, member 3 [Homo sapiens] Length = 483 Score = 103 bits (256), Expect = 1e-21 Identities = 127/453 (28%), Positives = 172/453 (37%), Gaps = 62/453 (13%) Query: 208 IPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASP----HTVGTRLFPPGGVTKWKSDVA 263 +P PP PP PPL PPPPP+ AP PP P++P T R P G + +D+ Sbjct: 1 MPVPP---PPPPPLP---PPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQ 54 Query: 264 LNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPT--PVRTSSIPVQEAQ 321 R + T+ + +P S+ G N E + PPT + PV Sbjct: 55 QGTRLRKVTQINDRSAPQIE--SSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPA 112 Query: 322 EAPRKEEGATKKAP-SRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQ 380 G T + P SR P P R P G L PASPRLG + Sbjct: 113 GQRDVAGGKTGQGPGSRAPSP--------------RLPNKTISGPL--IPPASPRLGNT- 155 Query: 381 SQADERAGTPPPAPPLPPPAPPLPPPAPP-LPPAAP-PLPCAQKAAHPPAGFTK-TPKSS 437 S+A A T PP P +P P PP PPP PP LPP P P PP TK Sbjct: 156 SEAHGAARTAPPRPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVV 215 Query: 438 SPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVA 497 +P + P PP P + P+ + ++ +LA P P + Sbjct: 216 APPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPP-------IPPPLPLLP 268 Query: 498 PQSKEGKKG-PRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQ 556 P G K P P ++ PP P +S + + P+ LP V+ + Sbjct: 269 PCGYPGLKAEPASPAQDA-------QEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSE 321 Query: 557 DSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPP--KPRLEGGRICENGADDDKLSKPV 614 P + + + + A A P+ PP +P L+ R GA KL+ P Sbjct: 322 TPPPLPPKSPSFQAPPQKAGAQALPAPPA----PPGSQPFLQKKRHGRPGAGGGKLNPPP 377 Query: 615 AKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATP 647 A PP + PTT L K+ A P P Sbjct: 378 A---PPARS---PTTELSSKSQQATAWTPTQQP 404 Score = 94.0 bits (232), Expect = 8e-19 Identities = 102/326 (31%), Positives = 117/326 (35%), Gaps = 92/326 (28%) Query: 142 PPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPH 201 PP P G + +P P P APPPP PPPPP PPP P + P Sbjct: 146 PPASPRLGNTSEAHGAARTAP-PRPNVPAPPPPT----PPPPPPPLPPPLPSSSPIKTP- 199 Query: 202 TLSSPSIPTPPDFIPP-APPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKS 260 L SP P +P APP+ PPPPP P P PP PP V S Sbjct: 200 -LVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPP-----------LPPASVL---S 244 Query: 261 DVALNGRQAEATRAS-PPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQE 319 D A+ + A PP P P G EP + P Q+ Sbjct: 245 DKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEP-------------------ASPAQD 285 Query: 320 AQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQS 379 AQE P AP PLPP P +A+ PA P G + Sbjct: 286 AQEPP---------APPP-PLPPYASCSP------------------RASLPAPPLPGVN 317 Query: 380 QSQADERAGTPPPAPPLPPP--APPLPP-----PAPPLPPAAPPLPCAQKAAHPPAGFTK 432 S TPPP PP P APP PAPP PP + P ++ P AG K Sbjct: 318 SSSE-----TPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGK 372 Query: 433 TPKSSSPALKPKPNPP--SPENTASS 456 L P P PP SP SS Sbjct: 373 --------LNPPPAPPARSPTTELSS 390 Score = 89.4 bits (220), Expect = 2e-17 Identities = 88/292 (30%), Positives = 112/292 (38%), Gaps = 73/292 (25%) Query: 138 LIPPPPP-----GPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPP 192 LIPP P A G + + P P P PP+ PPPPPL PPP PS +P P Sbjct: 144 LIPPASPRLGNTSEAHGAART-APPRPNVPAPPPPTPPPPPPPL---PPPLPSSSPIKTP 199 Query: 193 VLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTV------- 245 ++ SPP L+ ++P PP P APPPPP P P P P P +V Sbjct: 200 LV---SPPGPLTKGNLPV---VAPPVP----CAPPPPPPPPPPTPPPLPPASVLSDKAVK 249 Query: 246 -------------GTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNP 292 L PP G K++ A + A+ A PP P S P Sbjct: 250 PQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLP 309 Query: 293 EPHLT-FPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQ 351 P L S + PPP P ++ S +AP ++ GA LP PP+ P SQ Sbjct: 310 APPLPGVNSSSETPPPLPPKSPSF------QAPPQKAGA-----QALPAPPA---PPGSQ 355 Query: 352 VYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPL 403 + L+ P G + PPPAPP P L Sbjct: 356 PF------------LQKKRHGRPGAGGGKL-------NPPPAPPARSPTTEL 388 Score = 77.4 bits (189), Expect = 7e-14 Identities = 79/294 (26%), Positives = 100/294 (34%), Gaps = 82/294 (27%) Query: 141 PPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPP----------PPLLLEPPPPPSMAPPP 190 PPPP P P PP P SP+ +P + P P PP+ PPPPP PPP Sbjct: 174 PPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPP---PPP 230 Query: 191 PPVLEALSPPHTLSSPSIPTP--PDFIPPAPPLAFLAPP-------------------PP 229 PP L P LS ++ P +PP PP L PP PP Sbjct: 231 PPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPP 290 Query: 230 PVPAPAPP-APASPHTVGTRLFPPGGVTKWKSDVALNGR----QAEATRASPPRSPAEPK 284 P P PP A SP PG + ++ L + QA +A PA P Sbjct: 291 APPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPA 350 Query: 285 GSALGPNPEPHLTFPRSFKV--------PPPTPVRTSSIPVQEAQEAPRKEEGATKKAPS 336 P +P L R + PPP P S E K + AT P+ Sbjct: 351 P----PGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSP-----TTELSSKSQQATAWTPT 401 Query: 337 RLP--------------------------LPPSFHIRPASQVYPDRAPEPDCPG 364 + P PP +P ++YP + P PG Sbjct: 402 QQPGGQLRNGSLHIIDDFESKFTFHSVEDFPPPDEYKPCQKIYPSKIPRSRTPG 455 Score = 54.7 bits (130), Expect = 5e-07 Identities = 121/508 (23%), Positives = 157/508 (30%), Gaps = 121/508 (23%) Query: 394 PPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENT 453 P PPP PPLPPP PPL PP P A PP +T Sbjct: 2 PVPPPPPPPLPPPPPPLGAPPPPPPSA--------------------------PPVSTDT 35 Query: 454 ASSAPVDWRDPSQMEKLRNELAAYLCGSR-REDRFLSHRPGPTVAPQSKEGKKGPRLPEK 512 +S D + S + LA G+R R+ ++ R P + K+G Sbjct: 36 SSLRRADPKGRSAL------LADIQQGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANT 89 Query: 513 ETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEA 572 TPP + + GG P +R A Sbjct: 90 R------GASTPPTLGDLFAGGF-------------------------PVLRP------A 112 Query: 573 RLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQ 632 A + GS P PRL I S P+ +PP S L T+ Sbjct: 113 GQRDVAGGKTGQGPGSRAPSPRLPNKTI----------SGPL---IPPASPRLGNTSEAH 159 Query: 633 PKAMLGPA-----IPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTT----PL 683 A P PP TP P PP P++ P TPL + GP T P+ Sbjct: 160 GAARTAPPRPNVPAPPPPTPPPPPPPLPPPLPSSSP-----IKTPLVSPPGPLTKGNLPV 214 Query: 684 KATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQA--RGEGSPSEAT 741 A P P T P P S + P A P Sbjct: 215 VAPPVPCAPPPPPPPPPPTP---------PPLPPASVLSDKAVKPQLAPLHLPPIPPPLP 265 Query: 742 RLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPV 801 LP G A P + E P P +S S ++ P L PG Sbjct: 266 LLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPL-------PGVNS 318 Query: 802 EVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGR 861 + PP LP K P+ P + + GS L Q+ + GR GA G+ Sbjct: 319 SSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFL-----QKKRHGRP-GAGGGK 372 Query: 862 SSLPGSLRDHSHQAEASSDSIFHSQGTP 889 + P + S E SS S + TP Sbjct: 373 LNPPPAPPARSPTTELSSKSQQATAWTP 400 Score = 43.1 bits (100), Expect = 0.002 Identities = 68/270 (25%), Positives = 90/270 (33%), Gaps = 39/270 (14%) Query: 800 PVEVKEPPGLPAKPPA-SAQPTDELLRHPVTGEV--VERGSPM--ALLLAARQRAQKGRS 854 PV PP LP PP A P PV+ + + R P + LLA Q+ + R Sbjct: 2 PVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRK 61 Query: 855 VGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVV-----PKLPKEAEKD---- 905 V RS+ P E + TP + + P L ++D Sbjct: 62 VTQINDRSA-PQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGG 120 Query: 906 ---------SPLTTEIPNKW---------GPRLGRDAEGTELSR----RHNWTKPEPQAP 943 +P + +PNK PRLG +E +R R N P P P Sbjct: 121 KTGQGPGSRAP-SPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTP 179 Query: 944 VAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDP-EPPAPA 1002 P LP P+ SPP P K PPPP P PP P Sbjct: 180 PPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPP 239 Query: 1003 LQYLGRQSSPPRNNYSDLRQLPNAGPGAPP 1032 L ++ P+ L +P P PP Sbjct: 240 ASVLSDKAVKPQLAPLHLPPIPPPLPLLPP 269 >gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens] Length = 855 Score = 101 bits (251), Expect = 5e-21 Identities = 112/420 (26%), Positives = 154/420 (36%), Gaps = 68/420 (16%) Query: 158 PGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPP 217 P P P+ P P L+ PP + PP AL P LSS + TP P Sbjct: 257 PSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGP---LSSSPLATPS----P 309 Query: 218 APPLAFLAPPPPPV-------------PAP-APPAPASPHTVGTRLFPPGGVTKWKSDVA 263 + L APP P P P APP+P++P ++ T PP ++ + Sbjct: 310 SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPS-QATTS 368 Query: 264 LNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEA 323 L +AT + P P P + PP P + P+Q A Sbjct: 369 LGSPTLQATHSFLPSPPLSPLATP-----------------PPQAPPALALPPLQ----A 407 Query: 324 PRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQ--- 380 P + +P P P + + + +P P P + + PASP + S Sbjct: 408 PPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPP 467 Query: 381 SQADERAGTPP-PAPPLPPPAPPLPPPAPPLPPAAPPL--PCAQKAAHPPAGFTKTPKSS 437 SQA PP PP PP +PP+ P A P P A PPL P Q A PP P + Sbjct: 468 SQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQA---PPALA 524 Query: 438 SPALKPKPNPP---------SPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFL 488 +P L+ P+PP SP + +P+ P L L Sbjct: 525 TPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQ 584 Query: 489 SHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPG-VPEKSLGGSSLTETEAAPSLT 547 + R PT P + GPRL TL P PP P +L G L ++ + T Sbjct: 585 APRRPPTPGPDT--SVSGPRL----TLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATST 638 Score = 95.1 bits (235), Expect = 3e-19 Identities = 131/498 (26%), Positives = 170/498 (34%), Gaps = 60/498 (12%) Query: 141 PPPPGPAPGPPQDISEP-----PGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLE 195 P P G P ++ P P PL S P P P L PP A P L Sbjct: 272 PKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLT 331 Query: 196 A-LSPPHTLSSPS---------IPTPPDFIP-------------------PAPPLAFLAP 226 L+ P L+ PS +P+PP P P+PPL+ LA Sbjct: 332 CQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLAT 391 Query: 227 PPPPVPAPA---PPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAE- 282 PPP P PA PP A P + P ++ AL +A + PP P + Sbjct: 392 PPPQAP-PALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQA 450 Query: 283 ----PKGSALGPNPEPHLTFPRSFKVPP--PTPVRTSSIPVQEAQEAPRKEEGATKKAPS 336 P + P+ P P S PP P +S P+ + P + P Sbjct: 451 PFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPL 510 Query: 337 RLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPL 396 +L PP P + P P P AP SP S S TPPP P Sbjct: 511 QLAKPPP--QAPPALATPPLQALPSPPASFPGQAPFSP----SASLPMSPLATPPPQAPP 564 Query: 397 PPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPP---SPENT 453 AP L PP PPA+P L ++ P + + + AL P P PP SP +T Sbjct: 565 VLAAPLL--QVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSST 622 Query: 454 ASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLP-EK 512 S + S EL Y G A +GP P Sbjct: 623 LSGPDLAGHS-SSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAF 681 Query: 513 ETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEA 572 P P P + G ++ ETE S T P SP S + A Sbjct: 682 RGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGA 741 Query: 573 RLSSAAEKEAKPSIGSLP 590 SS + K+A+ +G LP Sbjct: 742 GASSRSPKQAR--LGELP 757 Score = 94.4 bits (233), Expect = 6e-19 Identities = 196/750 (26%), Positives = 257/750 (34%), Gaps = 144/750 (19%) Query: 146 PAPGPPQDISEPPGGSPLPSPPST-----------APPPPPLL-----LEPPPPPSMAPP 189 PA P ++ P GSP P PP T A PL + P AP Sbjct: 17 PAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPR 76 Query: 190 PPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRL 249 P T S+ + P PPA APP +P P + + TR Sbjct: 77 AGP---------TRSAGTSSRNPASRPPASGRGERAPPAKNT-SPGPVSSPGRASGTTRP 126 Query: 250 FPPG--GVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNP-EPHLTFPRSFK--- 303 P G G+ + G+ EA + S + A S GP P P R + Sbjct: 127 GPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTS--GPTPGTPSPAMARRSRAAG 184 Query: 304 ----VPPPTPVRTSSIPVQEAQEAPRK------EEGATKKAPS--RLPLPPSFHIRPASQ 351 +P P P P E PRK E T+ +P+ R P RPAS+ Sbjct: 185 TEVGLPRPAPSARPRPPT----EGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASR 240 Query: 352 VYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPL- 410 A P +A +PR SQ + P + PP P PL Sbjct: 241 SLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS 300 Query: 411 -PPAAPPLPCAQKAAHPPAGFTKTPKSSS---------PALKPKPNPPSPENTASSAPVD 460 P A P P A + P TP SSS P P P+ P T S P Sbjct: 301 SSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPA- 359 Query: 461 WRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPA 520 PSQ A GS S P P ++P + P+ P L L A Sbjct: 360 -TPPSQ--------ATTSLGSPTLQATHSFLPSPPLSPLA---TPPPQAPPALALPPLQA 407 Query: 521 KDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAA-- 578 +PP P S + + A ++ L + P SP P +S +A Sbjct: 408 PPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSP-PVQAPFSPPASPPVSPSATP 466 Query: 579 EKEAKPSIGS----LPPKPRLEGGRICENGADDDKLSKPVA------KNLPPQSTTLLPT 628 +A PS+ + +PP P + + + P+A PPQ+ L T Sbjct: 467 PSQAPPSLAAPPLQVPPSPP-ASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALAT 525 Query: 629 TSLQ-----PKAMLGPA---------IPPKATPEPAIPPKATL----WPATPPKATLGPA 670 LQ P + G A + P ATP P PP P +PP + A Sbjct: 526 PPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQA 585 Query: 671 TPLKATSGPTTPLKATSGPAIA-STATTLPTTTSQLMAEKDSGP--AGQPEKPASQEVST 727 T GP T + SGP + + A P S+ + SGP AG +S ST Sbjct: 586 PRRPPTPGPDT---SVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGH----SSSATST 638 Query: 728 PSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMP 787 P + RG S E +AA PP P CH ++ SR A P Sbjct: 639 PEELRGYDSGPEG---------GAAASPP---------PDAELAACHPAAWSRGPA---P 677 Query: 788 TLARGGAAGPGEPVEVKEPPGLPAKPPASA 817 LA GA PG P+ P PA P SA Sbjct: 678 PLAFRGA--PGAPL-----PWPPATGPGSA 700 Score = 94.0 bits (232), Expect = 8e-19 Identities = 192/785 (24%), Positives = 265/785 (33%), Gaps = 171/785 (21%) Query: 126 GDLRPGQYGQDLLI--------------PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAP 171 G RPG GQ L P + G +D S P G+P P+ + Sbjct: 122 GTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSR 181 Query: 172 PPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPV 231 + P P PS P PP P ++SS S + + Sbjct: 182 AAGTEVGLPRPAPSARPRPPTE----GPRKSVSSASEHSTTE------------------ 219 Query: 232 PAPAPPAPASPHTVGTRLFPPG-GVTKWKSDVALNGRQAEATRASP--PRSPAEPKGSAL 288 P+P A P G P ++ + ++ R + R +P P P++PK L Sbjct: 220 --PSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGL 277 Query: 289 GPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPP---SFH 345 P +T PR P P+ +S + P +AP LP P S Sbjct: 278 QALRPPQVTPPRKDAAPALGPLSSSPLAT------PSPSAALQSQAPPTLPATPHSSSLT 331 Query: 346 IRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPP--------PAPPLP 397 + A+ + P P P P L+ T P+ P SQA G+P P+PPL Sbjct: 332 CQLATPL-PLAPPSPSAPPSLQ-TLPSPP--ATPPSQATTSLGSPTLQATHSFLPSPPLS 387 Query: 398 PPA--PPLPPPAPPLPPA-APPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTA 454 P A PP PPA LPP APP P A PP SP P P P Sbjct: 388 PLATPPPQAPPALALPPLQAPPSP----PASPPL---------SPLATPSPQAP------ 428 Query: 455 SSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKET 514 N LA +L + S P P V + P P Sbjct: 429 -----------------NALAVHLLQAP-----FSPPPSPPV--------QAPFSPPASP 458 Query: 515 LLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARL 574 +S A TPP SL L + P+ S P P + +L Sbjct: 459 PVSPSA--TPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPP 516 Query: 575 SSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPK 634 A A P + +LP P G+ A P S + P + P+ Sbjct: 517 PQAPPALATPPLQALPSPPASFPGQ---------------APFSPSASLPMSPLATPPPQ 561 Query: 635 AMLGPAIPPKATPEPAIPPKATLWPAT----------PPKATLGPATPLKATSGP----- 679 A P A P +PP P P + GP L GP Sbjct: 562 AP-----PVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPS 616 Query: 680 TTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAG--QPEKPASQEVSTPSQARGEGSP 737 +P SGP +A +++ +T +L DSGP G P E++ A P Sbjct: 617 RSPSSTLSGPDLAGHSSSATSTPEELRG-YDSGPEGGAAASPPPDAELAACHPAAWSRGP 675 Query: 738 SEATRLPTQGARSS-AAFPPKTSPGGGEVPC-LYKPHCHQSSLSREVAV---VMPTLARG 792 A L +GA + +PP T PG + C +Y+ +S+ A+ P + G Sbjct: 676 --APPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGG 733 Query: 793 -GAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQK 851 AAG G G ++ P A+ EL + VV+ LLLAA + A Sbjct: 734 KAAAGAG--------AGASSRSPKQAR-LGELPLGALQASVVQHLLSRTLLLAAAEGAAG 784 Query: 852 GRSVG 856 G G Sbjct: 785 GSGGG 789 Score = 93.6 bits (231), Expect = 1e-18 Identities = 120/427 (28%), Positives = 149/427 (34%), Gaps = 68/427 (15%) Query: 92 LAVPTPSVPDDFADKEVTGTSSLVNGNLRLYSSVGDLRPGQYGQDLLIPPPPPGPAPGPP 151 LA P+PS P T S + +S+G P +P PP P PP Sbjct: 340 LAPPSPSAPPSLQ----TLPSPPATPPSQATTSLGS--PTLQATHSFLPSPPLSPLATPP 393 Query: 152 QDISEPPGGSPLPSPPSTAPPPPPLLLEPPPP-------------PSMAPPPPPVLEALS 198 PL +PPS PP L P P P PP PPV S Sbjct: 394 PQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFS 453 Query: 199 PPHTLSSPSIPTPPDFIPP---APPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGV 255 PP + TPP PP APPL PP PP P P+ P L P Sbjct: 454 PPASPPVSPSATPPSQAPPSLAAPPLQ--VPPSPPASPPMSPSATPPPQAPPPLAAP--- 508 Query: 256 TKWKSDVALNGRQAEATRASPP-RSPAEPKGSALGPNP-EPHLTFPRS-FKVPPPTPVRT 312 +A QA A+PP ++ P S G P P + P S PPP Sbjct: 509 ---PLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPV 565 Query: 313 SSIPVQEAQEAPRKEEGATKKAPSRLPLPP----------SFHIRPASQVYPDRAPE--- 359 + P+ Q P T +AP R P P + + P P R+P Sbjct: 566 LAAPL--LQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTL 623 Query: 360 --PDCPG-ELKATAPASPRLGQSQSQADERAGTPPPAPPLPP--PAPPLPPPAPPLP-PA 413 PD G AT+ G A +PPP L PA PAPPL Sbjct: 624 SGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRG 683 Query: 414 APPLPCAQKAAHPPAGF--------TKTPKSSSP---ALKPKPNPPSPENTASS---APV 459 AP P A P T+ P+S++P AL P P+P + A++ A Sbjct: 684 APGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGA 743 Query: 460 DWRDPSQ 466 R P Q Sbjct: 744 SSRSPKQ 750 Score = 74.3 bits (181), Expect = 6e-13 Identities = 210/883 (23%), Positives = 281/883 (31%), Gaps = 170/883 (19%) Query: 376 LGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPL--------------PCAQ 421 + + +A A PA P P PP +P PP P P A+ Sbjct: 1 MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE 60 Query: 422 KAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGS 481 +A G P+S+ A + S N AS P R + +N + Sbjct: 61 RAG--GIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRG-ERAPPAKNTSPGPVSSP 117 Query: 482 RREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTP----------------- 524 R + RPGP G+KG R+ +ET+ A + P Sbjct: 118 GRASG--TTRPGPL-------GQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPT 168 Query: 525 PGVPEKSLG-GSSLTETEAAPSLTLPSV-DYIPQDSPTPSVRQIRNELEARLSSAAEKEA 582 PG P ++ S TE PS P + P SV S AA + Sbjct: 169 PGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARR-- 226 Query: 583 KPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPK-----AML 637 +PS G +P R + A LS P + T P QPK A+ Sbjct: 227 RPSAGGGLQRP---ASRSLSSSA--TPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALR 281 Query: 638 GPAI-PPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTAT 696 P + PP+ PA+ P ++ P AT P+ L++ + PT P S AT Sbjct: 282 PPQVTPPRKDAAPALGPL-----SSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLAT 336 Query: 697 TLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGE-GSPS-EATR--LPTQGARSSA 752 LP L S P P S + PSQA GSP+ +AT LP+ A Sbjct: 337 PLP-----LAPPSPSAPPSLQTLP-SPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLA 390 Query: 753 AFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAA---------GPGEPVEV 803 PP+ P P P S +A P A P PV+ Sbjct: 391 TPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQA 450 Query: 804 K-EPPGLP-----AKPPASAQPT--DELLRHPVTGEVVERGSPMALLLAARQRAQKGRSV 855 PP P A PP+ A P+ L+ P + SP A + Sbjct: 451 PFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPL 510 Query: 856 GAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNK 915 A P +L QA S + F Q P P + SPL T Sbjct: 511 QLAKPPPQAPPALATPPLQALPSPPASFPGQ--------APFSPSASLPMSPLAT----- 557 Query: 916 WGPRLGRDAEGTELSRRHNWTKPEPQAPVAWE----RVAPSNLPQGHPLPKSFSSPPSPS 971 P PQAP +V PS P P ++ PP+P Sbjct: 558 ----------------------PPPQAPPVLAAPLLQVPPS--PPASPTLQAPRRPPTPG 593 Query: 972 NKREEEEEEFNFEVIP-PPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLRQL---PNAG 1027 + P PPP S P G SS + +LR P G Sbjct: 594 PDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSS-ATSTPEELRGYDSGPEGG 652 Query: 1028 PGAPP----------ALGFSRFPA-GARYAGAGGL----ERFSGGGRSLIKKRLYVGE-- 1070 A P +SR PA + GA G +G G + +Y E Sbjct: 653 AAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGP 712 Query: 1071 ----PHRG---PGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHA------ 1117 P G PG G +G ++ G P+ R+ G P G L A Sbjct: 713 ESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARL---GELPLGALQASVVQHL 769 Query: 1118 -PRLSLEGAARGAAEAKHKAPGSADYGFAPAAGRSPYTTTRYG 1159 R L AA GAA PG A+ G R+ + G Sbjct: 770 LSRTLLLAAAEGAAGGSGGGPGGAEGGGVTGGARAALSDAELG 812 >gi|110832843 TBP-associated factor 4 [Homo sapiens] Length = 1085 Score = 101 bits (251), Expect = 5e-21 Identities = 149/589 (25%), Positives = 197/589 (33%), Gaps = 106/589 (17%) Query: 149 GPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSI 208 G P + +P P AP PPP P P PP SP Sbjct: 65 GSPAGAAGAGPAAPAEGAPGAAPEPPPAGRARPGGGGPQRPGPP------------SPRR 112 Query: 209 PTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQ 268 P P PAPP A L PPP P PA+ P G K AL Sbjct: 113 PLVP--AGPAPPAAKLRPPPEGSAGSCAPVPAAAAVAAGPEPAPAGPAKPAGPAAL---- 166 Query: 269 AEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEE 328 A RA P P GP P P P P S + + A Sbjct: 167 --AARAGPGPGPGP------GPGPGPGPGKPAG---PGAAQTLNGSAALLNSHHAAAPAV 215 Query: 329 GATKKAPSR-LPLP----PSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQA 383 P+ LPLP P I+ V P P P A APA+P Sbjct: 216 SLVNNGPAALLPLPKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPAPAAP--------- 266 Query: 384 DERAGTPPPAPPLP-----PPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSS 438 A PPP PP P PP P PP PA PP AQ A P + Sbjct: 267 ---AAAPPPPPPAPATLARPPGHPAGPPT--AAPAVPPPAAAQNGGSAGAAPAPAPAAGG 321 Query: 439 PALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAP 498 PA P A + V P ++ + A L S S GPT+ Sbjct: 322 PAGVSGQPGPGAAAAAPAPGVKAESPKRVVQAAPPAAQTLAASGPASTAASMVIGPTMQ- 380 Query: 499 QSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGG--SSLTETEAA----------PSL 546 LP + PA TP G+P+ + G SL+ T A P++ Sbjct: 381 --------GALP-SPAAVPPPAPGTPTGLPKGAAGAVTQSLSRTPTATTSGIRATLTPTV 431 Query: 547 TLPSVDYIPQDSPT--------PSVRQIRNE--------LEARLSSAAEKEAKPSIGSLP 590 P + PQ +PT P + +R+E +A A+ A+P ++ Sbjct: 432 LAPRLPQPPQ-NPTNIQNFQLPPGMVLVRSENGQLLMIPQQALAQMQAQAHAQPQT-TMA 489 Query: 591 PKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPE-- 648 P+P A ++S A P + + PTT ++ + + P AT + Sbjct: 490 PRP------ATPTSAPPVQISTVQAPGTPIIARQVTPTTIIKQVSQAQTTVQPSATLQRS 543 Query: 649 PAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATT 697 P + P+ L A A+LG AT ++ TP + G S+A T Sbjct: 544 PGVQPQLVLGGAA-QTASLGTATAVQT----GTPQRTVPGATTTSSAAT 587 Score = 76.3 bits (186), Expect = 2e-13 Identities = 173/723 (23%), Positives = 249/723 (34%), Gaps = 134/723 (18%) Query: 140 PPPPPGPAPGPPQDISEPPGGSP--------LPSPPSTAP--------PPPPLLLEPPPP 183 P P PGP PGP PG + L S + AP P L L P Sbjct: 174 PGPGPGPGPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAA 233 Query: 184 PSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPA----- 238 P PP + A +PP +P+ P+PP PA P A APPPPP PAP Sbjct: 234 PGTVIQTPPFVGAAAPP----APAAPSPPAAPAPAAPAA--APPPPP---PAPATLARPP 284 Query: 239 --PASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHL 296 PA P T + PP A NG A A A PA G G + +P Sbjct: 285 GHPAGPPTAAPAVPPPA--------AAQNGGSAGAAPA-----PAPAAGGPAGVSGQPG- 330 Query: 297 TFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDR 356 P + P V+ S P + Q AP PA+Q Sbjct: 331 --PGAAAAAPAPGVKAES-PKRVVQAAP-----------------------PAAQTLAAS 364 Query: 357 APEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPP 416 P A+ AS +G + G P +PPPAP P P A Sbjct: 365 GP---------ASTAASMVIGPTMQ------GALPSPAAVPPPAPGTPTGLPKGAAGAVT 409 Query: 417 LPCAQKAAHPPAGF--TKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNEL 474 ++ +G T TP +P L P+P P +P N +++ P M +R+E Sbjct: 410 QSLSRTPTATTSGIRATLTPTVLAPRL-PQP-PQNPTNIQ-----NFQLPPGMVLVRSEN 462 Query: 475 AAYLCGSRR---EDRFLSH-RPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTP----PG 526 L ++ + + +H +P T+AP+ P + + ++ A TP Sbjct: 463 GQLLMIPQQALAQMQAQAHAQPQTTMAPRPATPTSAPPV----QISTVQAPGTPIIARQV 518 Query: 527 VPEKSLGGSSLTETEAAPSLTLP-SVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKP- 584 P + S +T PS TL S PQ + + + + + P Sbjct: 519 TPTTIIKQVSQAQTTVQPSATLQRSPGVQPQLVLGGAAQTASLGTATAVQTGTPQRTVPG 578 Query: 585 -SIGSLPPKPRLEGGRICENG-------ADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAM 636 + S +E + C+N A K S A N+ LL Sbjct: 579 ATTTSSAATETMENVKKCKNFLSTLIKLASSGKQSTETAANVKELVQNLLDGKIEAEDFT 638 Query: 637 LGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTAT 696 ++P+P + P L + P L P + P TS A TA Sbjct: 639 SRLYRELNSSPQPYLVP--FLKRSLPALRQLTPDSAAFIQQSQQQPPPPTSQATTALTAV 696 Query: 697 TLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAF-- 754 L +++ Q A K + +P ++ P+Q G G + T L Q A Sbjct: 697 VL-SSSVQRTAGKTAATVTSALQPPVLSLTQPTQV-GVGKQGQPTPLVIQQPPKPGALIR 754 Query: 755 PPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPP 814 PP+ + + L +PH +M T + P +PV V +P LP Sbjct: 755 PPQVTLTQTPMVALRQPHNR----------IMLTTPQQIQLNPLQPVPVVKPAVLPGTKA 804 Query: 815 ASA 817 SA Sbjct: 805 LSA 807 Score = 72.8 bits (177), Expect = 2e-12 Identities = 99/356 (27%), Positives = 126/356 (35%), Gaps = 67/356 (18%) Query: 110 GTSSLVNGNLRLYSSVGDLRPG----QYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPS 165 G + +NG+ L +S P G L+P P P APG + + P + Sbjct: 193 GAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPA-APGT---VIQTPPFVGAAA 248 Query: 166 PPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLA 225 PP+ A P PP P P + PPPPP P TL+ PP P PP A A Sbjct: 249 PPAPAAPSPPAAPAPAAPAAAPPPPPPA------PATLA-----RPPGH-PAGPPTAAPA 296 Query: 226 PPPP------------PVPAPAPPAPA----SPHTVGTRLFPPGGV--TKWKSDVALNGR 267 PPP P PAPA PA P P GV K V Sbjct: 297 VPPPAAAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAPAPGVKAESPKRVVQAAPP 356 Query: 268 QAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKE 327 A+ AS P S A +GP + L P + VPPP P + +P A Sbjct: 357 AAQTLAASGPASTA--ASMVIGPTMQGALPSPAA--VPPPAPGTPTGLPKGAA------- 405 Query: 328 EGATKKAPSRLPLPPSFHIRP--ASQVYPDRAPEPD-----------CPGELKATAPASP 374 GA ++ SR P + IR V R P+P PG + + Sbjct: 406 -GAVTQSLSRTPTATTSGIRATLTPTVLAPRLPQPPQNPTNIQNFQLPPGMVLVRSENGQ 464 Query: 375 RL---GQSQSQADERAGTPPPAPPLPPPAPPL-PPPAPPLPPAAPPLPCAQKAAHP 426 L Q+ +Q +A P P PA P PP AP P + P Sbjct: 465 LLMIPQQALAQMQAQAHAQPQTTMAPRPATPTSAPPVQISTVQAPGTPIIARQVTP 520 Score = 42.7 bits (99), Expect = 0.002 Identities = 49/201 (24%), Positives = 68/201 (33%), Gaps = 33/201 (16%) Query: 638 GPAIPPKA-TPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTAT 696 GP P + P PP A L P PP+ + G P+ A + +GP A Sbjct: 106 GPPSPRRPLVPAGPAPPAAKLRP--PPEGSAGSCAPVPAAAA------VAAGPEPAPAGP 157 Query: 697 TLPTTTSQLMAEKDSGPA-----------GQPEKPASQEVSTPSQA--RGEGSPSEATRL 743 P + L A GP G+P P + + S A + + A L Sbjct: 158 AKPAGPAALAARAGPGPGPGPGPGPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSL 217 Query: 744 PTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAG------- 796 G + P +PG + P ++ A P A AA Sbjct: 218 VNNGPAALLPLPKPAAPG----TVIQTPPFVGAAAPPAPAAPSPPAAPAPAAPAAAPPPP 273 Query: 797 PGEPVEVKEPPGLPAKPPASA 817 P P + PPG PA PP +A Sbjct: 274 PPAPATLARPPGHPAGPPTAA 294 Score = 41.6 bits (96), Expect = 0.005 Identities = 83/350 (23%), Positives = 107/350 (30%), Gaps = 50/350 (14%) Query: 638 GPAIP----PKATPEPAIPPKATLWPATPPKATLGPATPLK--ATSGPTTPLKATSGPAI 691 GPA P P A PEP PP P GP +P + +GP P P Sbjct: 74 GPAAPAEGAPGAAPEP--PPAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKLRPPPE 131 Query: 692 ASTATTLPTTTSQLMAE-KDSGPAGQPEKPASQEVST------------PSQARGEGSPS 738 S + P + +A + PAG P KPA P G G P+ Sbjct: 132 GSAGSCAPVPAAAAVAAGPEPAPAG-PAKPAGPAALAARAGPGPGPGPGPGPGPGPGKPA 190 Query: 739 EATRLPTQGARSS------AAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARG 792 T ++ AA P + G L P V+ T Sbjct: 191 GPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPK------PAAPGTVIQTPPFV 244 Query: 793 GAAGPGEPVEVKEP----PGLPAKPPASAQPTDELLRHPVTGEVVERGSPMAL-LLAARQ 847 GAA P P P P PA P P L P G P A + Sbjct: 245 GAAAPPAPAAPSPPAAPAPAAPAAAPPPPPPAPATLARPPGHPA---GPPTAAPAVPPPA 301 Query: 848 RAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSP 907 AQ G S GAA + G S Q + + + G V + PK + +P Sbjct: 302 AAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAPAPG------VKAESPKRVVQAAP 355 Query: 908 LTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQG 957 + GP A + P P A P+ LP+G Sbjct: 356 PAAQTLAASGP--ASTAASMVIGPTMQGALPSPAAVPPPAPGTPTGLPKG 403 Score = 35.8 bits (81), Expect = 0.25 Identities = 56/229 (24%), Positives = 77/229 (33%), Gaps = 47/229 (20%) Query: 938 PEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPE 997 P+P AP + P P P + S P +P+ P P + P Sbjct: 229 PKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPA---------------PAAPAAAPPPP 273 Query: 998 PPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGLERF--- 1054 PPAPA L R P P A P PP PA A+ G+ G Sbjct: 274 PPAPAT--LARPPGHPAGP-------PTAAPAVPP-------PAAAQNGGSAGAAPAPAP 317 Query: 1055 SGGGRSLIKKRLYVGEPHRGPGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGG 1114 + GG + + G+P G G SP Q P + + ++G A Sbjct: 318 AAGGPAGVS-----GQPGPGAAAAAPAPGVKAESPKRV-VQAAPPAAQTLAASGPASTAA 371 Query: 1115 LHAPRLSLEGAARGAAEAKHKAPGSADYGFAPAAG-------RSPYTTT 1156 +++GA A APG+ AAG R+P TT Sbjct: 372 SMVIGPTMQGALPSPAAVPPPAPGTPTGLPKGAAGAVTQSLSRTPTATT 420 Score = 31.6 bits (70), Expect = 4.7 Identities = 55/237 (23%), Positives = 66/237 (27%), Gaps = 25/237 (10%) Query: 950 APSNLPQGHPLPKSFS----SPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQY 1005 AP P G P PPSP + PPPE S P PA Sbjct: 86 APEPPPAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKLRPPPEGSAGSCAPVPAAAA 145 Query: 1006 LGRQSSP----PRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSL 1061 + P P AGPG P G P + AG G + +G L Sbjct: 146 VAAGPEPAPAGPAKPAGPAALAARAGPGPGPGPGPGPGPGPGKPAGPGAAQTLNGSAALL 205 Query: 1062 IKKRL---YVGEPHRGPG----LPH-GGTGRSLSSPNCFG---------PQPGGPEMRRV 1104 V + GP LP G + +P G P P Sbjct: 206 NSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPAPAA 265 Query: 1105 NSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAPGSADYGFAPAAGRSPYTTTRYGSP 1161 +A PP A G G A P A +AG +P G P Sbjct: 266 PAAAPPPPPPAPATLARPPGHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAGGP 322 >gi|46852161 methyl-CpG binding domain protein 6 [Homo sapiens] Length = 1003 Score = 100 bits (250), Expect = 6e-21 Identities = 238/967 (24%), Positives = 314/967 (32%), Gaps = 185/967 (19%) Query: 139 IPPPPPGPAPG----PPQDISEPPGGSPLPSPPS------TAPPP----PPLLLEPPP-- 182 + P PP P P ++ PG P P PPS T P PP L +P P Sbjct: 138 VSPGPPSARPPCRVPPTTPLNGGPGSLP-PEPPSVSQAFPTLAGPGGLFPPRLADPVPSG 196 Query: 183 ------------PPSMAPPPPPVLEALSPPHTLSSP--SIPTPPDF-IPPAPPLAFLAPP 227 PS APPPPP + +P + + S P D PPAP + P Sbjct: 197 GSSSPRFLPRGNAPSPAPPPPPAISLNAPSYNWGAALRSSLVPSDLGSPPAPHASSSPPS 256 Query: 228 PPPV--------PAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRS 279 PP+ P P PP+ P G PP + L T P Sbjct: 257 DPPLFHCSDALTPPPLPPSNNLPAHPGPASQPPVSSATMHLPLVLGPLGGAPTVEGPGAP 316 Query: 280 P--AEPKGSALGPNPEPHLTFPRSFKVPPP---TPVRTSSIPVQEAQEAPRKEEGATKKA 334 P A SA P L P + + P P + S ++ +Q PR+ + Sbjct: 317 PFLASSLLSAAAKAQHPPLPPPSTLQGRRPRAQAPSASHSSSLRPSQRRPRRPPTVFRLL 376 Query: 335 PSRLPLPP--SFHIRPASQVYPDRAPEPDCP------GELKATAPASPRLGQSQSQADER 386 R P P S PA P PEP P L P S + Sbjct: 377 EGRGPQTPRRSRPRAPAPVPQPFSLPEPSQPILPSVLSLLGLPTPGPSHSDGSFNLLGSD 436 Query: 387 AGTPPPAPPLPPPAPPLP--PPAPPLP----------PAAPPLPCAQKAAHPPAGFTKTP 434 A PPP P L +PP P P P LP P AP P A KA P+ ++P Sbjct: 437 AHLPPP-PTLSSGSPPQPRHPIQPSLPGTTSGSLSSVPGAPAPPAASKAPVVPSPVLQSP 495 Query: 435 KSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGP 494 S + P P P A + P Q L + G+ L P Sbjct: 496 -SEGLGMGAGPACPLPP-LAGGEAFPFPSPEQGLALSGAGFPGMLGALPLPLSLGQPPPS 553 Query: 495 TVAPQSKEG--KKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVD 552 + S G G P E LL P PP P + G S L + P P D Sbjct: 554 PLLNHSLFGVLTGGGGQPPPEPLLPPPGGPGPPLAPGEPEGPSLLVASLLPP----PPSD 609 Query: 553 YIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSK 612 +P S PS N L + L P + P EG G + S Sbjct: 610 LLPPPSAPPS-----NLLASFL---------PLLALGPTAGDGEGSAEGAGGPSGEPFS- 654 Query: 613 PVAKNLPPQSTTLLPTTSLQPK--AMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPA 670 L S L P S P A+ + P PP+ + A P GP Sbjct: 655 ----GLGDLSPLLFPPLSAPPTLIALNSALLAATLDPPSGTPPQPCVLSAPQP----GPP 706 Query: 671 TPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQ 730 T + +TATT P +S A +SG Q P Sbjct: 707 T------------------SSVTTATTDPGASSLGKAPSNSGRPPQLLSPLLGASLLGDL 748 Query: 731 ARGEGSPSE-ATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTL 789 + SP + L G S + PGGG P L S S +A ++ +L Sbjct: 749 SSLTSSPGALPSLLQPPGPLLSGQLGLQLLPGGGAPPPL-------SEASSPLACLLQSL 801 Query: 790 ARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGS---PMALLLAAR 846 P E E P LP + PASA E R P++ GS P+ LL R Sbjct: 802 Q--------IPPEQPEAPCLPPESPASAL-EPEPARPPLSALAPPHGSPDPPVPELLTGR 852 Query: 847 QRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDS 906 ++GR G G LR + +A + S+ P + Sbjct: 853 GSGKRGRRGG---------GGLRGINGEARPARGRKPGSRREPGRLAL------------ 891 Query: 907 PLTTEIPNKWGPRLGRDAEGTELSRR-HNWTKPEPQAPVAWERVAPSNLPQGHPLPKSFS 965 KWG R G + + RR H+W + +A P + P P + Sbjct: 892 --------KWGTRGGFNGQMERSPRRTHHW---QHNGELAEGGAEPKDPPPPGPHSEDLK 940 Query: 966 SPPSPSNK-REEEEEEFNFEVIPPPPEFSN--------DPEPPAPALQYLGRQSSPPRNN 1016 PP K R ++N P SN +P P A A L ++ P R Sbjct: 941 VPPGVVRKSRRGRRRKYN------PTRNSNSSRQDITLEPSPTARAAVPLPPRARPGRPA 994 Query: 1017 YSDLRQL 1023 + R+L Sbjct: 995 KNKRRKL 1001 Score = 90.1 bits (222), Expect = 1e-17 Identities = 179/688 (26%), Positives = 232/688 (33%), Gaps = 158/688 (22%) Query: 82 LPLNAQE-NHGLAVPTPSVPDDFADKEVTGTSSLVNGNLRLYSSVGDLRPGQYGQDLLIP 140 + LNA N G A+ + VP D SS + L+ + D L P Sbjct: 220 ISLNAPSYNWGAALRSSLVPSDLGSPPAPHASSSPPSDPPLF----------HCSDALTP 269 Query: 141 PP---------PPGPAPGPPQD--------ISEPPGGSPLPSPPSTAPPPPPLLLE---- 179 PP PGPA PP + P GG+P P P LL Sbjct: 270 PPLPPSNNLPAHPGPASQPPVSSATMHLPLVLGPLGGAPTVEGPGAPPFLASSLLSAAAK 329 Query: 180 ----PPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFL----------- 224 P PPPS P +A S H+ S P P PP F Sbjct: 330 AQHPPLPPPSTLQGRRPRAQAPSASHSSSL----RPSQRRPRRPPTVFRLLEGRGPQTPR 385 Query: 225 -------APPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPP 277 AP P P P P P P + P G + SD + N ++A PP Sbjct: 386 RSRPRAPAPVPQPFSLPEPSQPILPSVLSLLGLPTPGPSH--SDGSFNLLGSDAHLPPPP 443 Query: 278 R----SPAEPKGSALGPNPEPHLTFPRSFKVP-PPTPVRTSSIPVQEAQEAPRKEEGATK 332 SP +P+ + P+ P T VP P P S PV + EG Sbjct: 444 TLSSGSPPQPR-HPIQPSL-PGTTSGSLSSVPGAPAPPAASKAPVVPSPVLQSPSEGLGM 501 Query: 333 KAPSRLPLPPSFHIRPASQVYPDRAPEPDC-------PGELKATA--------PASPRLG 377 A PLPP + +P +PE PG L A P SP L Sbjct: 502 GAGPACPLPPL----AGGEAFPFPSPEQGLALSGAGFPGMLGALPLPLSLGQPPPSPLLN 557 Query: 378 QSQSQADERAGTPPPAPP-LPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKS 436 S G PP P LPPP P PP AP P P L A PP+ Sbjct: 558 HSLFGVLTGGGGQPPPEPLLPPPGGPGPPLAPG-EPEGPSLLVASLLPPPPSD------- 609 Query: 437 SSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTV 496 L P P+ P AS P+ P+ + E +A G GP+ Sbjct: 610 ----LLPPPSAPPSNLLASFLPLLALGPTAGD---GEGSAEGAG------------GPSG 650 Query: 497 APQSKEGKKG----PRLPEKETLLSL----------PAKDTPP-----GVPEKSLGGSSL 537 P S G P L TL++L P TPP P+ SS+ Sbjct: 651 EPFSGLGDLSPLLFPPLSAPPTLIALNSALLAATLDPPSGTPPQPCVLSAPQPGPPTSSV 710 Query: 538 TETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARL-----SSAAEKEAKPSIGSLPPK 592 T P + S+ P +S P + + L A L S + A PS+ PP Sbjct: 711 TTATTDPGAS--SLGKAPSNSGRPP-QLLSPLLGASLLGDLSSLTSSPGALPSL-LQPPG 766 Query: 593 PRLEGG---RICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKA---- 645 P L G ++ G LS+ + LL + + P+ P +PP++ Sbjct: 767 PLLSGQLGLQLLPGGGAPPPLSEASS-----PLACLLQSLQIPPEQPEAPCLPPESPASA 821 Query: 646 -TPEPAIPPKATLWPATPPKATLGPATP 672 PEPA PP + L PP + P P Sbjct: 822 LEPEPARPPLSAL---APPHGSPDPPVP 846 Score = 75.5 bits (184), Expect = 3e-13 Identities = 224/944 (23%), Positives = 301/944 (31%), Gaps = 172/944 (18%) Query: 277 PRSPAEPKGSALGPNPEPHLT---FPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKK 333 P +P P G+ +GP E +T R V T R+ + EGA+ + Sbjct: 78 PLAPVTPGGAGVGPASEEDMTKLCNHRRKAVAMATLYRSMETTCSHSSPG----EGASPQ 133 Query: 334 APSRL-PLPPSFHIRPASQVYPDRAPEPDCPGELKATAPA---------------SPRL- 376 + P PPS RP +V P P PG L P+ PRL Sbjct: 134 MFHTVSPGPPS--ARPPCRV-PPTTPLNGGPGSLPPEPPSVSQAFPTLAGPGGLFPPRLA 190 Query: 377 ------GQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGF 430 G S + R P PAPP PPPA L P+ A PPA Sbjct: 191 DPVPSGGSSSPRFLPRGNAPSPAPP-PPPAISLNAPSYNWGAALRSSLVPSDLGSPPAPH 249 Query: 431 TKTPKSSSP-------ALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRR 483 + S P AL P P PPS A P + P + L Sbjct: 250 ASSSPPSDPPLFHCSDALTPPPLPPSNNLPAHPGPAS-QPPVSSATMHLPLVL------- 301 Query: 484 EDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGG--------- 534 GP + EG P L + PP P +L G Sbjct: 302 ---------GPLGGAPTVEGPGAPPFLASSLLSAAAKAQHPPLPPPSTLQGRRPRAQAPS 352 Query: 535 ----SSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSS-----AAEKEAKPS 585 SSL ++ P P+V + + + R+ R A + + PS Sbjct: 353 ASHSSSLRPSQRRPRRP-PTVFRLLEGRGPQTPRRSRPRAPAPVPQPFSLPEPSQPILPS 411 Query: 586 IGSL----PPKPRLEGGRICENGADDDKLSKP-VAKNLPPQ-----STTLLPTTSLQPKA 635 + SL P P G G+D P ++ PPQ +L TTS + Sbjct: 412 VLSLLGLPTPGPSHSDGSFNLLGSDAHLPPPPTLSSGSPPQPRHPIQPSLPGTTSGSLSS 471 Query: 636 MLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTA 695 + G PP A+ P +P P+ GPA PL +G + +A + Sbjct: 472 VPGAPAPPAASKAPVVPSPVLQSPSEGLGMGAGPACPLPPLAGGEAFPFPSPEQGLALSG 531 Query: 696 TTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFP 755 P L G P P G G P LP G Sbjct: 532 AGFPGMLGALPLPLSLGQ--PPPSPLLNHSLFGVLTGGGGQPPPEPLLPPPGGPG----- 584 Query: 756 PKTSPGGGEVPCLY--------------KPHCHQSSLSREVAVVMPTLARGGAAGPGE-- 799 P +PG E P L P S+L +A +P LA G AG GE Sbjct: 585 PPLAPGEPEGPSLLVASLLPPPPSDLLPPPSAPPSNL---LASFLPLLALGPTAGDGEGS 641 Query: 800 PVEVKEPPGLPAK----------PPASAQPTDELLRHPVTGEVVERGS---PMALLLAAR 846 P G P PP SA PT L + ++ S P +L+A Sbjct: 642 AEGAGGPSGEPFSGLGDLSPLLFPPLSAPPTLIALNSALLAATLDPPSGTPPQPCVLSAP 701 Query: 847 QRAQKGRSVGAAL---GRSSLPGSLRDHSHQAEASSDSIFHS-QGTPNSFTVVP-KLPKE 901 Q SV A G SSL + + + S + S G +S T P LP Sbjct: 702 QPGPPTSSVTTATTDPGASSLGKAPSNSGRPPQLLSPLLGASLLGDLSSLTSSPGALPSL 761 Query: 902 AEKDSPLTT-EIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPL 960 + PL + ++ + P G +E S P A + P P+ L Sbjct: 762 LQPPGPLLSGQLGLQLLPGGGAPPPLSEAS--------SPLACLLQSLQIPPEQPEAPCL 813 Query: 961 PKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDL 1020 P P SP++ E E + PP P+PP P L R L Sbjct: 814 P-----PESPASALEPEPARPPLSALAPP---HGSPDPPVPELLTGRGSGKRGRRGGGGL 865 Query: 1021 RQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPH- 1079 R + A PA G R P R G L+ + GG + G+ R P H Sbjct: 866 RGINGE---ARPARG--RKPGSRREPGRLALKWGTRGG--------FNGQMERSPRRTHH 912 Query: 1080 ----GGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPR 1119 G + P P P GP + + PPG + R Sbjct: 913 WQHNGELAEGGAEPK--DPPPPGPHSEDL----KVPPGVVRKSR 950 >gi|221139926 NHS-like 1 [Homo sapiens] Length = 1606 Score = 95.5 bits (236), Expect = 3e-19 Identities = 137/516 (26%), Positives = 204/516 (39%), Gaps = 81/516 (15%) Query: 62 SESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLRL 121 S+S T T + P+ FL + N G P P VP+ + + S+ + + L Sbjct: 854 SQSNTPTA-----LTPVPVFLKSVSPAN-GKGKPKPKVPE--RKSSLISSVSISSSSTSL 905 Query: 122 YSSVGDLRPGQYGQ-DLLI---PPPPPGPAPGPPQDISEPPGGSPL--PSPPST-----A 170 SS G + D + P PPP P P PP P SP P PP T + Sbjct: 906 SSSTSTEGSGTMKKLDPAVGSPPAPPPPPVPSPPFPC--PADRSPFLPPPPPVTDCSQGS 963 Query: 171 PPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPP 230 P P + PPPP ++ P P LSPP SP +P P +P PPL P Sbjct: 964 PLPHSPVFPPPPPEALIPFCSPPDWCLSPPRPALSPILPDSPVSLPLPPPLL-----PSS 1018 Query: 231 VPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGP 290 P PAPP TR PP N Q E++R S R P+ + ++ P Sbjct: 1019 EPPPAPPLDPK-FMKDTR--PP----------FTNSGQPESSRGS-LRPPSTKEETSRPP 1064 Query: 291 NPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPAS 350 P L + ++ PVR +S A+ A E A ++ R P+ P +H++P++ Sbjct: 1065 MP---LITTEALQMVQLRPVRKNS----GAEAAQLSERTAQEQ---RTPVAPQYHLKPSA 1114 Query: 351 QVYP-DRAPEPDCPGELKATAPASPRLGQSQSQAD-----ERAGTPPPAPPLPPPAPPLP 404 + + E + + + + P +S SQ D ER G +P P Sbjct: 1115 FLKSRNSTNEMESESQPASVTSSLPTPAKSSSQGDHGSAAERGGPVSRSPGAPSAGEAEA 1174 Query: 405 PPAP---PLPPAAP---PLPCAQK------AAHPPAGFTKTP-KSSSPALKPKPNP---- 447 P+P PLP ++P P P ++K P F P ++ S AL+ P+P Sbjct: 1175 RPSPSTTPLPDSSPSRKPPPISKKPKLFLVVPPPQKDFAVEPAENVSEALRAVPSPTTGE 1234 Query: 448 -------PSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQS 500 + E++A+ A P L A + SR E +P + AP+ Sbjct: 1235 EGSVHSREAKESSAAQAGSHATHPG-TSVLEGGAAGSMSPSRVEANVPMVQPDVSPAPKQ 1293 Query: 501 KEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSS 536 +E + + L +D GVPE + GSS Sbjct: 1294 EEPAENSADTGGDGESCLSQQDGAAGVPETNAAGSS 1329 Score = 68.6 bits (166), Expect = 3e-11 Identities = 122/463 (26%), Positives = 155/463 (33%), Gaps = 112/463 (24%) Query: 126 GDLRPGQYGQDLLIPPPPPG---PAPGPPQD----ISEPPGGSPLPSPPSTAPPPPPLLL 178 G +R Q G +P P G P P+ IS G S + P+ P P L Sbjct: 811 GPVRHVQEGSRATMPQVPGGSVKPKIMSPEKSHRVISPSSGYSSQSNTPTALTPVPVFLK 870 Query: 179 EPPPPPSMAPPPPPVLE---------ALSPPHTLSSPSIPTPP-------DFIPPAPPLA 222 P P P V E ++S T S S T D +PP Sbjct: 871 SVSPANGKGKPKPKVPERKSSLISSVSISSSSTSLSSSTSTEGSGTMKKLDPAVGSPP-- 928 Query: 223 FLAPPPPPVPAPAPPAPA--SPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASP-PRS 279 APPPPPVP+P P PA SP L PP VT + ++ SP P S Sbjct: 929 --APPPPPVPSPPFPCPADRSPF-----LPPPPPVT-------------DCSQGSPLPHS 968 Query: 280 PAEPKGSALGPNPEPHLTF--PRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSR 337 P P P PE + F P + + PP P + +P +P Sbjct: 969 PVFPP-----PPPEALIPFCSPPDWCLSPPRPALSPILP----------------DSPVS 1007 Query: 338 LPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLP 397 LPLPP + P+S+ P AP D P +K T P GQ +S Sbjct: 1008 LPLPPP--LLPSSE--PPPAPPLD-PKFMKDTRPPFTNSGQPESSRGS------------ 1050 Query: 398 PPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSA 457 L PP+ + PP+P A K+S + E A Sbjct: 1051 -----LRPPSTKEETSRPPMPLITTEALQMVQLRPVRKNSGAEAAQLSERTAQEQRTPVA 1105 Query: 458 PVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLS 517 P PS K RN S+ S PT A S +G G Sbjct: 1106 PQYHLKPSAFLKSRNSTNEMESESQPASVTSSL---PTPAKSSSQGDHGSAAER------ 1156 Query: 518 LPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPT 560 G +S G S E EA PS PS +P SP+ Sbjct: 1157 -------GGPVSRSPGAPSAGEAEARPS---PSTTPLPDSSPS 1189 Score = 54.7 bits (130), Expect = 5e-07 Identities = 198/910 (21%), Positives = 287/910 (31%), Gaps = 242/910 (26%) Query: 323 APRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGE----LKATAPASPRLGQ 378 +P + P+ L P F ++ S P+P P + + + +S Sbjct: 847 SPSSGYSSQSNTPTALTPVPVF-LKSVSPANGKGKPKPKVPERKSSLISSVSISSSSTSL 905 Query: 379 SQSQADERAGTPPPAPPL--PPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKS 436 S S + E +GT P PPAPP PPP P +PP PC P Sbjct: 906 SSSTSTEGSGTMKKLDPAVGSPPAPP-PPPVP-----SPPFPC--------------PAD 945 Query: 437 SSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTV 496 SP L P PP + + +P L H P V Sbjct: 946 RSPFLPP---PPPVTDCSQGSP-----------------------------LPHSP---V 970 Query: 497 APQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQ 556 P P + LS P P +P+ + SL LP +P Sbjct: 971 FPPPPPEALIPFCSPPDWCLSPPRPALSPILPDSPV------------SLPLPP-PLLPS 1017 Query: 557 DSPTPSVR---QIRNELEARLSSAAEKEAKPSIGSL-PPKPRLEGGRICENGADDDKLSK 612 P P+ + + +++ + E+ S GSL PP + E R Sbjct: 1018 SEPPPAPPLDPKFMKDTRPPFTNSGQPES--SRGSLRPPSTKEETSR------------- 1062 Query: 613 PVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATP--PKATLGPA 670 PP L+ T +LQ L P + + TP P+ L P+ Sbjct: 1063 ------PPMP--LITTEALQ-MVQLRPVRKNSGAEAAQLSERTAQEQRTPVAPQYHLKPS 1113 Query: 671 TPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQ 730 LK+ + T +++ S PA +++ P +S ++ D G A + P S+ PS Sbjct: 1114 AFLKSRNS-TNEMESESQPASVTSSLPTPAKSS---SQGDHGSAAERGGPVSRSPGAPSA 1169 Query: 731 ARGEGSPSEAT---------RLPTQGARSSAAF----PPK------------------TS 759 E PS +T R P ++ F PP+ S Sbjct: 1170 GEAEARPSPSTTPLPDSSPSRKPPPISKKPKLFLVVPPPQKDFAVEPAENVSEALRAVPS 1229 Query: 760 PGGGEVPCLYKPHCHQSSLSREVAVVM---PTLARGGAAGPGEP--VEVKEPPGLPAKPP 814 P GE ++ +SS ++ + ++ GGAAG P VE P P P Sbjct: 1230 PTTGEEGSVHSREAKESSAAQAGSHATHPGTSVLEGGAAGSMSPSRVEANVPMVQPDVSP 1289 Query: 815 ASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQ 874 A Q P G + L +Q+ + G ++ Sbjct: 1290 APKQ------EEPAENSADTGGDGESCL------SQQDGAAGV------------PETNA 1325 Query: 875 AEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHN 934 A +SS++ + N + P P+ E L I LGR + SR H+ Sbjct: 1326 AGSSSEACDFLKEDGNDEVMTPSRPRTTE---DLFAAIHRSKRKVLGRRDSDDDHSRNHS 1382 Query: 935 WTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIP------- 987 P PV APS PK S K + F ++ Sbjct: 1383 -----PSPPVTPTGAAPSLAS-----PKQVGSIQRSIRKSSTSSDNFKALLLKKGSRSDT 1432 Query: 988 ------------PPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALG 1035 P F P+P SP +N + N G P +L Sbjct: 1433 SARMSAAEMLKNTDPRFQRSRSEPSPDAPESPSSCSPSKNRRAQEEWAKNEGL-MPRSLS 1491 Query: 1036 FSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHGGTGRSLSSPNCFGPQ 1095 FS G RY GRS P + R SSP + Sbjct: 1492 FS----GPRY------------GRS--------RTPPSAASSRYSMRNRIQSSPMTVISE 1527 Query: 1096 PGGPEMRRVNSAGRAPPGGLHAPRLSLEGAAR-------------GAAEAKHKAPGSADY 1142 G + V+S R G A SL+G AR AA + +APG D Sbjct: 1528 GEGEAVEPVDSIARGALGA--AEGCSLDGLAREEMDEGGLLCGEGPAASLQPQAPGPVD- 1584 Query: 1143 GFAPAAGRSP 1152 G A A GR P Sbjct: 1585 GTASAEGREP 1594 Score = 34.3 bits (77), Expect = 0.73 Identities = 78/394 (19%), Positives = 129/394 (32%), Gaps = 86/394 (21%) Query: 520 AKDTPPGVPEKSLGGS---SLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSS 576 ++ T P VP GGS + E + + PS Y Q + ++ + L Sbjct: 820 SRATMPQVP----GGSVKPKIMSPEKSHRVISPSSGYSSQSNTPTALTPVPVFL------ 869 Query: 577 AAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTS------ 630 K P+ G PKP++ + K S + ++ ST+L +TS Sbjct: 870 ---KSVSPANGKGKPKPKVP----------ERKSSLISSVSISSSSTSLSSSTSTEGSGT 916 Query: 631 ---LQPKAMLGPAIPPKATPEPAIP------------------------PKATLWPATPP 663 L P PA PP P P P P + ++P PP Sbjct: 917 MKKLDPAVGSPPAPPPPPVPSPPFPCPADRSPFLPPPPPVTDCSQGSPLPHSPVFPPPPP 976 Query: 664 KAT----------LGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGP 713 +A L P P + P +P+ P + ++ P KD+ P Sbjct: 977 EALIPFCSPPDWCLSPPRPALSPILPDSPVSLPLPPPLLPSSEPPPAPPLDPKFMKDTRP 1036 Query: 714 ----AGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLY 769 +GQPE +S+ P + E S + T+ + P + + G Sbjct: 1037 PFTNSGQPE--SSRGSLRPPSTKEETSRPPMPLITTEALQMVQLRPVRKNSGAEAAQLSE 1094 Query: 770 KPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVT 829 + Q + + P+ E +P + + P A+ + + Sbjct: 1095 RTAQEQRTPVAPQYHLKPSAFLKSRNSTNEMESESQPASVTSSLPTPAKSSSQ----GDH 1150 Query: 830 GEVVERGSPMALLLAARQRAQKGRSVGAALGRSS 863 G ERG P++ R+ S G A R S Sbjct: 1151 GSAAERGGPVS-------RSPGAPSAGEAEARPS 1177 >gi|55750053 atrophin-1 [Homo sapiens] Length = 1190 Score = 95.5 bits (236), Expect = 3e-19 Identities = 151/650 (23%), Positives = 214/650 (32%), Gaps = 102/650 (15%) Query: 145 GPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPS----MAPPPPPVLEALSPP 200 G + GP + PP P P PP + P P EP P + AP PP P Sbjct: 150 GLSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAP 209 Query: 201 HTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKS 260 P P P + P L+ PP P + +VG P GG Sbjct: 210 -----PGAPPPHPQLYPGGTGGVLSGPP-----MGPKGGGAASSVGG---PNGGKQHPPP 256 Query: 261 DVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPR-SFKVPPPTPVRTSSIPVQE 319 ++ + A+ A P + P P G P+ P FP + +PPP +R P+ Sbjct: 257 TTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALR----PLNN 312 Query: 320 AQEAPRKEEGATKKAPSRLPLPPSF-----HIRPASQVYPDRAPEPDCPGELKATAPASP 374 A +P + P LP P + + P + P AP P ++APA P Sbjct: 313 ASASP--PGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPP 370 Query: 375 ------------RLGQSQSQADERAGTPPPAPPLPPPAP-PLPPPA-------PP--LPP 412 S S + + +P PA P P PPP PP P Sbjct: 371 MRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQP 430 Query: 413 AAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRN 472 + P + PP + + +S+ P P ++TA Q ++ + Sbjct: 431 SLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQ 490 Query: 473 ELAAYLCGSRREDRFLSHRPGPTVAPQSKEG---------------------KKGP-RLP 510 + +++ S P P P EG GP LP Sbjct: 491 QQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLP 550 Query: 511 EKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDS-----PTPSVRQ 565 + +S ++ P G P S SS + ++ + + PS PQ + P P+V Sbjct: 551 PPHSQVSY-SQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTT 609 Query: 566 IRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTL 625 L +++ A A S PP P G R GA PP T Sbjct: 610 SSATLSTVIATVASSPAGYKTAS-PPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRT- 667 Query: 626 LPTTSLQPKAMLGPAIPP--KATPEPAIPPKATLWPATPP--KATLGPATPLKATSGPTT 681 PP + T PA P T P +P L PA P S P Sbjct: 668 --------------GTPPGYRGTSPPAGP--GTFKPGSPTVGPGPLPPAGPSGLPSLPPP 711 Query: 682 PLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQA 731 P SGP +++T E PA P P + V PS A Sbjct: 712 PAAPASGPPLSATQIKQEPAEEYETPESPVPPARSP-SPPPKVVDVPSHA 760 Score = 90.5 bits (223), Expect = 9e-18 Identities = 253/1049 (24%), Positives = 344/1049 (32%), Gaps = 219/1049 (20%) Query: 147 APGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSP 206 +PG ++ S+ G L P+ PPPL P PP P P EA PH P Sbjct: 137 SPGSVENDSDSSSG--LSQGPARPYHPPPLFPPSPQPPDSTPRQP---EASFEPH----P 187 Query: 207 SIPTPPDFIPPAPPLAFLAPPPPPVPAPAP---PAPASPHTVGTRLFPPGGVTKWKSDVA 263 S+ P PP + + PP P P P P G + P GG Sbjct: 188 SVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGP 247 Query: 264 LNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEA 323 G+Q PP +P S P PP TPV ++P A Sbjct: 248 NGGKQHP-----PPTTPISVSSSGASGAPPTK---------PPTTPVGGGNLP-----SA 288 Query: 324 PRKEEGATKKAPSRLP-----LPPSFHIRP---ASQVYPDRAPEPDCPGELKATAPASPR 375 P P+ P LPP +RP AS P +P PG L P+ Sbjct: 289 P---------PPANFPHVTPNLPPPPALRPLNNASASPPGLGAQP-LPGHL----PSPHA 334 Query: 376 LGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAA-HPPAGFTKTP 434 +GQ PP P P L P+ LP A +A PP F + Sbjct: 335 MGQGMGGL-----------------PPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSS 377 Query: 435 KSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGP 494 SSS A + S ++AS P PS P P Sbjct: 378 SSSSSA-AASSSSSSSSSSASPFPASQALPSYPHSF---------------------PPP 415 Query: 495 TVAPQSKEGKKGPRLPEKETLLSLPAKDT-PPGVPEKSLGGSSLTETEAAPSLTLPSVDY 553 T S + P K T SLP++ G P G L + A P PS Sbjct: 416 TSLSVSNQ-------PPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGA 468 Query: 554 IPQDSPTPSV----RQIRNELEARLSSAAEKEAKPSIGSLPPKP-----RLEGGRICENG 604 P S Q + + + + +++ + S PP P LEGG Sbjct: 469 QSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAH 528 Query: 605 ADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPP-KATPEPAIPPKATLWPATPP 663 S + PP L P S + GP PP ++ + +P + P Sbjct: 529 PYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHP 588 Query: 664 KATLGP-ATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQP----- 717 + GP P P P TS A+ +T + T S K + P G P Sbjct: 589 SPSQGPQGAPYPF---PPVPTVTTSS---ATLSTVIATVASSPAGYKTASPPGPPPYGKR 642 Query: 718 -EKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQS 776 P + + +TP + PS T P G R TSP G P +KP Sbjct: 643 APSPGAYKTATPPGYKPGSPPSFRTGTP-PGYRG-------TSPPAG--PGTFKPG---- 688 Query: 777 SLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERG 836 PT+ GPG P+ P GLP+ PP A P G Sbjct: 689 ---------SPTV------GPG-PLPPAGPSGLPSLPPPPAAPAS--------------G 718 Query: 837 SPMALLLAARQRAQKGRS----VGAALGRSSLPGSLRDHSHQAEASS-----DSIFHSQG 887 P++ ++ A++ + V A S P + SH ++++ D F+S Sbjct: 719 PPLSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCA 778 Query: 888 TPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRL------GRDAEGTELSRRHNWTKPEPQ 941 + + V + K A+K + L ++ + R R+ E + R + E Sbjct: 779 RSDLYFVPLEGSKLAKKRADLVEKVRREAEQRAREEKEREREREREKEREREKERELERS 838 Query: 942 APVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAP 1001 +A E AP P P+P PP E V PP P P Sbjct: 839 VKLAQEGRAPVECPSLGPVP---HRPPF----------EPGSAVATVPPYLG----PDTP 881 Query: 1002 ALQYLGRQS-----SPPRNNYSDLRQLPNAGPGA----PPALGFSRFPAG---ARYAGAG 1049 AL+ L + SP N+ L PG PAL +S PA R A Sbjct: 882 ALRTLSEYARPHVMSPGNRNHPFYVPLGAVDPGLLGYNVPAL-YSSDPAAREREREARER 940 Query: 1050 GLERFSGGGRSLIKKRLYVGEPHRGPGLP----HGGTGRSLSSPNCFGPQPGGPEMRRVN 1105 L G + L GPGL HGG P P P P + + Sbjct: 941 DLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPRHGGLALQPGPPG-LHPFPFHPSLGPLE 999 Query: 1106 SAGRAPPGGLHAPRLSLEGAARGAAEAKH 1134 A G A R + A R AAE +H Sbjct: 1000 RERLALAAG-PALRPDMSYAERLAAERQH 1027 Score = 71.2 bits (173), Expect = 5e-12 Identities = 122/527 (23%), Positives = 165/527 (31%), Gaps = 95/527 (18%) Query: 125 VGDLRPGQYGQDLLIP-----PPPPGPAPGPPQDI---------------SEPPGGSPLP 164 +G L PG L P PP AP PP S S P Sbjct: 339 MGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASP 398 Query: 165 SPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDF---------- 214 P S A P P PP S++ PP + P + S P PP + Sbjct: 399 FPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAH 458 Query: 215 ---IPPA--------PPLAF---------------------------LAPPPPPVPAPAP 236 PP+ PP++ + PPPP P P Sbjct: 459 PGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHP 518 Query: 237 ----------PAPASPHTVGTRLFPPG--GVTKWKSDVALN--GRQAEATRASPPRSPAE 282 P SP R +PPG + S V+ + G +S S + Sbjct: 519 LEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSST 578 Query: 283 PKGSALGPNPEPHLTFPRSFKVP-PPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLP 341 +GS +P P P+ P PP P T+S A A K S P Sbjct: 579 SQGSYPCSHPSPS-QGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPP 637 Query: 342 PSFHIRPASQVYPDRAP---EPDCPGELKATAP-----ASPRLGQSQSQADERAGTPPPA 393 P P+ Y P +P P + P SP G + P P Sbjct: 638 PYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPL 697 Query: 394 PPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENT 453 PP P P PP P P + PPL Q PA +TP+S P + PP + Sbjct: 698 PPAGPSGLPSLPPPPAAPASGPPLSATQ-IKQEPAEEYETPESPVPPARSPSPPPKVVDV 756 Query: 454 ASSAPVDWRDPSQMEKLRNELA-AYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEK 512 S A R +++ N A + L E L+ + V +E ++ R EK Sbjct: 757 PSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVRREAEQRAR-EEK 815 Query: 513 ETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSP 559 E + E+ L S E + PS+ +P P Sbjct: 816 EREREREREKEREREKERELERSVKLAQEGRAPVECPSLGPVPHRPP 862 Score = 53.5 bits (127), Expect = 1e-06 Identities = 175/859 (20%), Positives = 252/859 (29%), Gaps = 189/859 (22%) Query: 252 PGGVTKWKSDVALN-----GRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPP 306 PGGV+ SD ++A AS P+ + + + + P+ K Sbjct: 35 PGGVSTSSSDGKAEKSRQTAKKARVEEASTPKVNKQGRSEEISESESEETNAPKKTKTEQ 94 Query: 307 PTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGEL 366 P S + ++G++ R Q +P PG + Sbjct: 95 ELPRPQSPSDLDSLDGRSLNDDGSSDP-------------RDIDQDNRSTSPSIYSPGSV 141 Query: 367 KATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHP 426 + + +S L Q ++ PP+P P P P + P+ P P Sbjct: 142 ENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPP 201 Query: 427 PAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDR 486 + + P + P P+ P S P+ + AA G + Sbjct: 202 TSRMFQAPPGAPPP-HPQLYPGGTGGVLSGPPMGPKGGG---------AASSVGGPNGGK 251 Query: 487 FLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSL 546 H P T S G G + P K PP P +GG +L A P Sbjct: 252 --QHPPPTTPISVSSSGASG----------APPTK--PPTTP---VGGGNL--PSAPPPA 292 Query: 547 TLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGAD 606 P V P P P++R + N + P +G+ P L G Sbjct: 293 NFPHV--TPNLPPPPALRPLNN----------ASASPPGLGAQPLPGHLPSPHAMGQGMG 340 Query: 607 DDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEP-AIPPKATLWPATPPKA 665 LPP GP P P P ++PP ++ PA P + Sbjct: 341 ----------GLPP-----------------GPEKGPTLAPSPHSLPPASSSAPAPPMRF 373 Query: 666 TLGPATPLK-ATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQE 724 ++ A S ++ +++ P AS A LP+ + QP P + Sbjct: 374 PYSSSSSSSAAASSSSSSSSSSASPFPASQA--LPSYPHSFPPPTSLSVSNQP--PKYTQ 429 Query: 725 VSTPSQA---RGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSRE 781 S PSQA +G P RL FPP T P + H H ++ Sbjct: 430 PSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQ 489 Query: 782 VAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMAL 841 + + ++ G PP A P HP+ G P A+ Sbjct: 490 QQQQQQ-----------QQQQQQQHHGNSGPPPPGAFP------HPLEGGSSHHAHPYAM 532 Query: 842 LLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKE 901 S GSLR P P Sbjct: 533 --------------------SPSLGSLR--------------------------PYPPGP 546 Query: 902 AEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPLP 961 A P + ++ GP G +S N + Q +PS PQG P P Sbjct: 547 AHLPPPHSQVSYSQAGP------NGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYP 600 Query: 962 KSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLR 1021 PP P+ + P PP P Y R SP + Sbjct: 601 ----FPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPP-PYGKRAPSPGAYKTA--- 652 Query: 1022 QLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPG-LPHG 1080 P PG+PP+ P G G +G G G P GPG LP Sbjct: 653 TPPGYKPGSPPSFRTGTPP------GYRGTSPPAGPG------TFKPGSPTVGPGPLPPA 700 Query: 1081 GTGRSLSSPNCFGPQPGGP 1099 G S P P P P Sbjct: 701 GPSGLPSLP----PPPAAP 715 Score = 51.6 bits (122), Expect = 4e-06 Identities = 53/173 (30%), Positives = 64/173 (36%), Gaps = 22/173 (12%) Query: 83 PLNAQENHGLAVPTPSVPDDFADKEVTGTS-SLVNGNLRLYSSVGDLRPGQYGQDLLIP- 140 P +Q G P P VP T + V + Y + P YG+ P Sbjct: 588 PSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPG 647 Query: 141 ----PPPPGPAPGPPQDI--SEPPG--GSPLPSPPSTAPPPPPLLLE---PPPPPSMAP- 188 PPG PG P PPG G+ P+ P T P P + PP PS P Sbjct: 648 AYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPS 707 Query: 189 -PPPPVLEALSPPHTLSSPSIPTPP-----DFIPPAPPLAFLAPPPPPVPAPA 235 PPPP A PP LS+ I P P PP +PPP V P+ Sbjct: 708 LPPPPAAPASGPP--LSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPS 758 >gi|55750041 atrophin-1 [Homo sapiens] Length = 1190 Score = 95.5 bits (236), Expect = 3e-19 Identities = 151/650 (23%), Positives = 214/650 (32%), Gaps = 102/650 (15%) Query: 145 GPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPS----MAPPPPPVLEALSPP 200 G + GP + PP P P PP + P P EP P + AP PP P Sbjct: 150 GLSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAP 209 Query: 201 HTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKS 260 P P P + P L+ PP P + +VG P GG Sbjct: 210 -----PGAPPPHPQLYPGGTGGVLSGPP-----MGPKGGGAASSVGG---PNGGKQHPPP 256 Query: 261 DVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPR-SFKVPPPTPVRTSSIPVQE 319 ++ + A+ A P + P P G P+ P FP + +PPP +R P+ Sbjct: 257 TTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALR----PLNN 312 Query: 320 AQEAPRKEEGATKKAPSRLPLPPSF-----HIRPASQVYPDRAPEPDCPGELKATAPASP 374 A +P + P LP P + + P + P AP P ++APA P Sbjct: 313 ASASP--PGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPP 370 Query: 375 ------------RLGQSQSQADERAGTPPPAPPLPPPAP-PLPPPA-------PP--LPP 412 S S + + +P PA P P PPP PP P Sbjct: 371 MRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQP 430 Query: 413 AAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRN 472 + P + PP + + +S+ P P ++TA Q ++ + Sbjct: 431 SLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQ 490 Query: 473 ELAAYLCGSRREDRFLSHRPGPTVAPQSKEG---------------------KKGP-RLP 510 + +++ S P P P EG GP LP Sbjct: 491 QQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLP 550 Query: 511 EKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDS-----PTPSVRQ 565 + +S ++ P G P S SS + ++ + + PS PQ + P P+V Sbjct: 551 PPHSQVSY-SQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTT 609 Query: 566 IRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTL 625 L +++ A A S PP P G R GA PP T Sbjct: 610 SSATLSTVIATVASSPAGYKTAS-PPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRT- 667 Query: 626 LPTTSLQPKAMLGPAIPP--KATPEPAIPPKATLWPATPP--KATLGPATPLKATSGPTT 681 PP + T PA P T P +P L PA P S P Sbjct: 668 --------------GTPPGYRGTSPPAGP--GTFKPGSPTVGPGPLPPAGPSGLPSLPPP 711 Query: 682 PLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQA 731 P SGP +++T E PA P P + V PS A Sbjct: 712 PAAPASGPPLSATQIKQEPAEEYETPESPVPPARSP-SPPPKVVDVPSHA 760 Score = 90.5 bits (223), Expect = 9e-18 Identities = 253/1049 (24%), Positives = 344/1049 (32%), Gaps = 219/1049 (20%) Query: 147 APGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSP 206 +PG ++ S+ G L P+ PPPL P PP P P EA PH P Sbjct: 137 SPGSVENDSDSSSG--LSQGPARPYHPPPLFPPSPQPPDSTPRQP---EASFEPH----P 187 Query: 207 SIPTPPDFIPPAPPLAFLAPPPPPVPAPAP---PAPASPHTVGTRLFPPGGVTKWKSDVA 263 S+ P PP + + PP P P P P G + P GG Sbjct: 188 SVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGP 247 Query: 264 LNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEA 323 G+Q PP +P S P PP TPV ++P A Sbjct: 248 NGGKQHP-----PPTTPISVSSSGASGAPPTK---------PPTTPVGGGNLP-----SA 288 Query: 324 PRKEEGATKKAPSRLP-----LPPSFHIRP---ASQVYPDRAPEPDCPGELKATAPASPR 375 P P+ P LPP +RP AS P +P PG L P+ Sbjct: 289 P---------PPANFPHVTPNLPPPPALRPLNNASASPPGLGAQP-LPGHL----PSPHA 334 Query: 376 LGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAA-HPPAGFTKTP 434 +GQ PP P P L P+ LP A +A PP F + Sbjct: 335 MGQGMGGL-----------------PPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSS 377 Query: 435 KSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGP 494 SSS A + S ++AS P PS P P Sbjct: 378 SSSSSA-AASSSSSSSSSSASPFPASQALPSYPHSF---------------------PPP 415 Query: 495 TVAPQSKEGKKGPRLPEKETLLSLPAKDT-PPGVPEKSLGGSSLTETEAAPSLTLPSVDY 553 T S + P K T SLP++ G P G L + A P PS Sbjct: 416 TSLSVSNQ-------PPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGA 468 Query: 554 IPQDSPTPSV----RQIRNELEARLSSAAEKEAKPSIGSLPPKP-----RLEGGRICENG 604 P S Q + + + + +++ + S PP P LEGG Sbjct: 469 QSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAH 528 Query: 605 ADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPP-KATPEPAIPPKATLWPATPP 663 S + PP L P S + GP PP ++ + +P + P Sbjct: 529 PYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHP 588 Query: 664 KATLGP-ATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQP----- 717 + GP P P P TS A+ +T + T S K + P G P Sbjct: 589 SPSQGPQGAPYPF---PPVPTVTTSS---ATLSTVIATVASSPAGYKTASPPGPPPYGKR 642 Query: 718 -EKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQS 776 P + + +TP + PS T P G R TSP G P +KP Sbjct: 643 APSPGAYKTATPPGYKPGSPPSFRTGTP-PGYRG-------TSPPAG--PGTFKPG---- 688 Query: 777 SLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERG 836 PT+ GPG P+ P GLP+ PP A P G Sbjct: 689 ---------SPTV------GPG-PLPPAGPSGLPSLPPPPAAPAS--------------G 718 Query: 837 SPMALLLAARQRAQKGRS----VGAALGRSSLPGSLRDHSHQAEASS-----DSIFHSQG 887 P++ ++ A++ + V A S P + SH ++++ D F+S Sbjct: 719 PPLSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCA 778 Query: 888 TPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRL------GRDAEGTELSRRHNWTKPEPQ 941 + + V + K A+K + L ++ + R R+ E + R + E Sbjct: 779 RSDLYFVPLEGSKLAKKRADLVEKVRREAEQRAREEKEREREREREKEREREKERELERS 838 Query: 942 APVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAP 1001 +A E AP P P+P PP E V PP P P Sbjct: 839 VKLAQEGRAPVECPSLGPVP---HRPPF----------EPGSAVATVPPYLG----PDTP 881 Query: 1002 ALQYLGRQS-----SPPRNNYSDLRQLPNAGPGA----PPALGFSRFPAG---ARYAGAG 1049 AL+ L + SP N+ L PG PAL +S PA R A Sbjct: 882 ALRTLSEYARPHVMSPGNRNHPFYVPLGAVDPGLLGYNVPAL-YSSDPAAREREREARER 940 Query: 1050 GLERFSGGGRSLIKKRLYVGEPHRGPGLP----HGGTGRSLSSPNCFGPQPGGPEMRRVN 1105 L G + L GPGL HGG P P P P + + Sbjct: 941 DLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPRHGGLALQPGPPG-LHPFPFHPSLGPLE 999 Query: 1106 SAGRAPPGGLHAPRLSLEGAARGAAEAKH 1134 A G A R + A R AAE +H Sbjct: 1000 RERLALAAG-PALRPDMSYAERLAAERQH 1027 Score = 71.2 bits (173), Expect = 5e-12 Identities = 122/527 (23%), Positives = 165/527 (31%), Gaps = 95/527 (18%) Query: 125 VGDLRPGQYGQDLLIP-----PPPPGPAPGPPQDI---------------SEPPGGSPLP 164 +G L PG L P PP AP PP S S P Sbjct: 339 MGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASP 398 Query: 165 SPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDF---------- 214 P S A P P PP S++ PP + P + S P PP + Sbjct: 399 FPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAH 458 Query: 215 ---IPPA--------PPLAF---------------------------LAPPPPPVPAPAP 236 PP+ PP++ + PPPP P P Sbjct: 459 PGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHP 518 Query: 237 ----------PAPASPHTVGTRLFPPG--GVTKWKSDVALN--GRQAEATRASPPRSPAE 282 P SP R +PPG + S V+ + G +S S + Sbjct: 519 LEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSST 578 Query: 283 PKGSALGPNPEPHLTFPRSFKVP-PPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLP 341 +GS +P P P+ P PP P T+S A A K S P Sbjct: 579 SQGSYPCSHPSPS-QGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPP 637 Query: 342 PSFHIRPASQVYPDRAP---EPDCPGELKATAP-----ASPRLGQSQSQADERAGTPPPA 393 P P+ Y P +P P + P SP G + P P Sbjct: 638 PYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPL 697 Query: 394 PPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENT 453 PP P P PP P P + PPL Q PA +TP+S P + PP + Sbjct: 698 PPAGPSGLPSLPPPPAAPASGPPLSATQ-IKQEPAEEYETPESPVPPARSPSPPPKVVDV 756 Query: 454 ASSAPVDWRDPSQMEKLRNELA-AYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEK 512 S A R +++ N A + L E L+ + V +E ++ R EK Sbjct: 757 PSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVRREAEQRAR-EEK 815 Query: 513 ETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSP 559 E + E+ L S E + PS+ +P P Sbjct: 816 EREREREREKEREREKERELERSVKLAQEGRAPVECPSLGPVPHRPP 862 Score = 53.5 bits (127), Expect = 1e-06 Identities = 175/859 (20%), Positives = 252/859 (29%), Gaps = 189/859 (22%) Query: 252 PGGVTKWKSDVALN-----GRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPP 306 PGGV+ SD ++A AS P+ + + + + P+ K Sbjct: 35 PGGVSTSSSDGKAEKSRQTAKKARVEEASTPKVNKQGRSEEISESESEETNAPKKTKTEQ 94 Query: 307 PTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGEL 366 P S + ++G++ R Q +P PG + Sbjct: 95 ELPRPQSPSDLDSLDGRSLNDDGSSDP-------------RDIDQDNRSTSPSIYSPGSV 141 Query: 367 KATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHP 426 + + +S L Q ++ PP+P P P P + P+ P P Sbjct: 142 ENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPP 201 Query: 427 PAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDR 486 + + P + P P+ P S P+ + AA G + Sbjct: 202 TSRMFQAPPGAPPP-HPQLYPGGTGGVLSGPPMGPKGGG---------AASSVGGPNGGK 251 Query: 487 FLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSL 546 H P T S G G + P K PP P +GG +L A P Sbjct: 252 --QHPPPTTPISVSSSGASG----------APPTK--PPTTP---VGGGNL--PSAPPPA 292 Query: 547 TLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGAD 606 P V P P P++R + N + P +G+ P L G Sbjct: 293 NFPHV--TPNLPPPPALRPLNN----------ASASPPGLGAQPLPGHLPSPHAMGQGMG 340 Query: 607 DDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEP-AIPPKATLWPATPPKA 665 LPP GP P P P ++PP ++ PA P + Sbjct: 341 ----------GLPP-----------------GPEKGPTLAPSPHSLPPASSSAPAPPMRF 373 Query: 666 TLGPATPLK-ATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQE 724 ++ A S ++ +++ P AS A LP+ + QP P + Sbjct: 374 PYSSSSSSSAAASSSSSSSSSSASPFPASQA--LPSYPHSFPPPTSLSVSNQP--PKYTQ 429 Query: 725 VSTPSQA---RGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSRE 781 S PSQA +G P RL FPP T P + H H ++ Sbjct: 430 PSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQ 489 Query: 782 VAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMAL 841 + + ++ G PP A P HP+ G P A+ Sbjct: 490 QQQQQQ-----------QQQQQQQHHGNSGPPPPGAFP------HPLEGGSSHHAHPYAM 532 Query: 842 LLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKE 901 S GSLR P P Sbjct: 533 --------------------SPSLGSLR--------------------------PYPPGP 546 Query: 902 AEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPLP 961 A P + ++ GP G +S N + Q +PS PQG P P Sbjct: 547 AHLPPPHSQVSYSQAGP------NGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYP 600 Query: 962 KSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLR 1021 PP P+ + P PP P Y R SP + Sbjct: 601 ----FPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPP-PYGKRAPSPGAYKTA--- 652 Query: 1022 QLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPG-LPHG 1080 P PG+PP+ P G G +G G G P GPG LP Sbjct: 653 TPPGYKPGSPPSFRTGTPP------GYRGTSPPAGPG------TFKPGSPTVGPGPLPPA 700 Query: 1081 GTGRSLSSPNCFGPQPGGP 1099 G S P P P P Sbjct: 701 GPSGLPSLP----PPPAAP 715 Score = 51.6 bits (122), Expect = 4e-06 Identities = 53/173 (30%), Positives = 64/173 (36%), Gaps = 22/173 (12%) Query: 83 PLNAQENHGLAVPTPSVPDDFADKEVTGTS-SLVNGNLRLYSSVGDLRPGQYGQDLLIP- 140 P +Q G P P VP T + V + Y + P YG+ P Sbjct: 588 PSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPG 647 Query: 141 ----PPPPGPAPGPPQDI--SEPPG--GSPLPSPPSTAPPPPPLLLE---PPPPPSMAP- 188 PPG PG P PPG G+ P+ P T P P + PP PS P Sbjct: 648 AYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPS 707 Query: 189 -PPPPVLEALSPPHTLSSPSIPTPP-----DFIPPAPPLAFLAPPPPPVPAPA 235 PPPP A PP LS+ I P P PP +PPP V P+ Sbjct: 708 LPPPPAAPASGPP--LSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPS 758 >gi|21361376 splicing factor 3a, subunit 2 [Homo sapiens] Length = 464 Score = 95.1 bits (235), Expect = 3e-19 Identities = 86/299 (28%), Positives = 110/299 (36%), Gaps = 54/299 (18%) Query: 164 PSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAF 223 P+PPS PP + PPP + PP PP+ E+L PP P P PP P+ P Sbjct: 218 PAPPSLPAGPPGVKRPPPPLMNGLPPRPPLPESLPPPPPGGLPLPPMPPTGPAPSGP--- 274 Query: 224 LAPP--PPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPA 281 PP PPP P PPAP H + + PP G A PP Sbjct: 275 PGPPQLPPPAPGVHPPAPV-VHPPASGVHPPA-----------PGVHPPAPGVHPPAPGV 322 Query: 282 EPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLP 341 P S + P P P + P + V PP P G AP P Sbjct: 323 HPPTSGVHP-PAPGV-HPPAPGVHPPAP-------------------GVHPPAPGVHPPA 361 Query: 342 PSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAP 401 P H P++ V+ P PG PA+P + + G PPAP + P AP Sbjct: 362 PGVHPPPSAGVH------PQAPG----VHPAAPAV------HPQAPGVHPPAPGMHPQAP 405 Query: 402 PLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVD 460 + P P + P+AP + HP P P L+P P N P + Sbjct: 406 GVHPQPPGVHPSAPGVHPQPPGVHPSNPGVHPPTPMPPMLRPPLPSEGPGNIPPPPPTN 464 Score = 91.3 bits (225), Expect = 5e-18 Identities = 94/293 (32%), Positives = 107/293 (36%), Gaps = 63/293 (21%) Query: 140 PPPPPGPAPGPPQDISEPP----GGSPLPSPPSTAPPPPP--LLLEPPPPPSMAPPPPPV 193 PP PP GPP PP G P P P + PPPPP L L P PP AP PP Sbjct: 217 PPAPPSLPAGPPGVKRPPPPLMNGLPPRPPLPESLPPPPPGGLPLPPMPPTGPAPSGPPG 276 Query: 194 LEALSPPHTLSSPSI-PTPPDFIPPA----PPLAFLAPPPPPVPAPAP---PAPASPHTV 245 L PP +P + P P PPA PP + PP P V PAP P + H Sbjct: 277 PPQLPPP----APGVHPPAPVVHPPASGVHPPAPGVHPPAPGVHPPAPGVHPPTSGVHPP 332 Query: 246 GTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVP 305 + PP A PP P + P P P + P S V Sbjct: 333 APGVHPP------------------APGVHPPAPGVHPPAPGVHP-PAPGVHPPPSAGVH 373 Query: 306 PPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAP--EPDCP 363 P P + P Q AP G AP P P H +P V+P AP P P Sbjct: 374 PQAPGVHPAAPAVHPQ-AP----GVHPPAPGMHPQAPGVHPQPPG-VHPS-APGVHPQPP 426 Query: 364 GELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPP 416 G P++P G PP P P PPLP P P PP Sbjct: 427 G----VHPSNP-------------GVHPPTPMPPMLRPPLPSEGPGNIPPPPP 462 Score = 61.2 bits (147), Expect = 6e-09 Identities = 58/199 (29%), Positives = 66/199 (33%), Gaps = 58/199 (29%) Query: 256 TKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSI 315 T W + Q PP P+ P G P K PPP P+ Sbjct: 197 THWNRETKQFFLQFHFKMEKPPAPPSLPAG-------------PPGVKRPPP-PLMNGLP 242 Query: 316 PVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPR 375 P P E P LPLPP P P P P P P+ Sbjct: 243 P------RPPLPESLPPPPPGGLPLPPM----------PPTGPAPSGP-------PGPPQ 279 Query: 376 LGQSQSQADERAGTPPPAPPLPPPAPPLPPPA----PPLPPAAPPLPCAQKAAHPPAGFT 431 L PPPAP + PPAP + PPA PP P PP P HPPA Sbjct: 280 L-------------PPPAPGVHPPAPVVHPPASGVHPPAPGVHPPAP----GVHPPAPGV 322 Query: 432 KTPKSSSPALKPKPNPPSP 450 P S P +PP+P Sbjct: 323 HPPTSGVHPPAPGVHPPAP 341 Score = 49.7 bits (117), Expect = 2e-05 Identities = 39/126 (30%), Positives = 46/126 (36%), Gaps = 10/126 (7%) Query: 130 PGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPP 189 PG + + PP PG P P PP P P PP P + PPP + P Sbjct: 320 PGVHPPTSGVHPPAPGVHPPAPG--VHPPAPGVHPPAPGVHPPAPG--VHPPPSAGVHPQ 375 Query: 190 PPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAP---PAPASPHTVG 246 P V A H + P P P AP + P PP V AP P P H Sbjct: 376 APGVHPAAPAVHPQAPGVHPPAPGMHPQAPG---VHPQPPGVHPSAPGVHPQPPGVHPSN 432 Query: 247 TRLFPP 252 + PP Sbjct: 433 PGVHPP 438 Score = 49.3 bits (116), Expect = 2e-05 Identities = 29/67 (43%), Positives = 33/67 (49%), Gaps = 6/67 (8%) Query: 130 PGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPP-PLLLEPPPP---PS 185 PG + Q + P PPG P P +PPG PS P PP P P +L PP P P Sbjct: 398 PGMHPQAPGVHPQPPGVHPSAPGVHPQPPGVH--PSNPGVHPPTPMPPMLRPPLPSEGPG 455 Query: 186 MAPPPPP 192 PPPPP Sbjct: 456 NIPPPPP 462 Score = 47.0 bits (110), Expect = 1e-04 Identities = 41/135 (30%), Positives = 50/135 (37%), Gaps = 18/135 (13%) Query: 123 SSVGDLRPGQYGQDLLIPPPPPGP---APG---PPQDISEPPGGSPLPSPPSTAPPPPPL 176 S V PG + + PP PG APG P + PP P P P P + Sbjct: 327 SGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPPSAGVHPQAPGVHPAAPAV 386 Query: 177 LLEP----PPPPSMAP------PPPPVLEALSPPHTLSSPSI-PTPPDFIPPAPPLAFLA 225 + PP P M P P PP + +P P + P+ P PP P L Sbjct: 387 HPQAPGVHPPAPGMHPQAPGVHPQPPGVHPSAPGVHPQPPGVHPSNPGVHPPTPMPPMLR 446 Query: 226 PP-PPPVPAPAPPAP 239 PP P P PP P Sbjct: 447 PPLPSEGPGNIPPPP 461 Score = 34.3 bits (77), Expect = 0.73 Identities = 63/247 (25%), Positives = 78/247 (31%), Gaps = 59/247 (23%) Query: 940 PQAPVAWERVAP---SNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDP 996 P P +R P + LP PLP+S PP +P PP P Sbjct: 224 PAGPPGVKRPPPPLMNGLPPRPPLPESLPPPPPGG--------------LPLPPMPPTGP 269 Query: 997 EPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSG 1056 P P PP QLP PG P PA + A G+ + Sbjct: 270 APSGP--------PGPP--------QLPPPAPGVHPPAPVVHPPASGVHPPAPGVHPPAP 313 Query: 1057 GGRSLIKKRLYVGEPHRGPGLPHGGTGRSLSSPNCFGPQPG----GPEMRRVNSAGRAPP 1112 G V P PG+ +G +P P PG P + P Sbjct: 314 G----------VHPP--APGVHPPTSGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPA 361 Query: 1113 GGLH-APRLSLEGAARG---AAEAKH-KAPGSADYGFAPAAGRSPYTTTRYGSPINTFTV 1167 G+H P + A G AA A H +APG PA G P + P Sbjct: 362 PGVHPPPSAGVHPQAPGVHPAAPAVHPQAPGV----HPPAPGMHPQAPGVHPQPPGVHPS 417 Query: 1168 RPGTRHP 1174 PG HP Sbjct: 418 APGV-HP 423 Score = 33.9 bits (76), Expect = 0.95 Identities = 27/74 (36%), Positives = 29/74 (39%), Gaps = 18/74 (24%) Query: 398 PPAPPLPPPAPP------------LPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKP 445 PPAPP P PP LPP PPLP + PP G P P P P Sbjct: 217 PPAPPSLPAGPPGVKRPPPPLMNGLPP-RPPLP--ESLPPPPPG--GLPLPPMPPTGPAP 271 Query: 446 N-PPSPENTASSAP 458 + PP P AP Sbjct: 272 SGPPGPPQLPPPAP 285 >gi|153792074 proline rich 12 [Homo sapiens] Length = 2036 Score = 95.1 bits (235), Expect = 3e-19 Identities = 130/507 (25%), Positives = 191/507 (37%), Gaps = 90/507 (17%) Query: 143 PPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPP---------PSMAPPPPPV 193 P GP P + PP LPS S P PPLL E PPP P PPPPP Sbjct: 1419 PDGPPLAPAAAVPGPPPLPGLPSANSNGTPEPPLLEEKPPPTPPPAPTPQPQPPPPPPPP 1478 Query: 194 LEAL--SPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPA----------PAPPAPAS 241 AL PP +PS P PP +PP PP A +PPPPP PA PA P+P Sbjct: 1479 QPALPSPPPLVAPTPSSPPPPP-LPPPPPPAMPSPPPPPPPAAAPLAAPPEEPAAPSPED 1537 Query: 242 PHTVGTRLFPPGGVTKWKSDVALNGR-QAEATRASPPRSPAEPKGSALGPNPEPHLTFPR 300 P TR P + K + A+ G EA + E + P L Sbjct: 1538 PELPDTR---PLHLAKKQETAAVCGETDEEAGESGGEGIFRERDEFVIRAEDIPSLKLAL 1594 Query: 301 SFKVPPPTPVRTSSIPVQ----EAQEAPRK---------EEGATKKAPSRLPLPPSFHIR 347 PP R +Q E ++ R+ G K RL + ++ Sbjct: 1595 QTGREPPPIWRVQKALLQKFTPEIKDGQRQFCATSNYLGYFGDAKNRYQRLYVKFLENVN 1654 Query: 348 PASQV-YPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPP 406 V R P P ++ + A + S A PPP P PPP P P Sbjct: 1655 KKDYVRVCARKPWHRPPVPVRRSGQAKNPVSAGGSSA------PPPKAPAPPPKPETPEK 1708 Query: 407 APPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQ 466 + PP +TP+++ P PP+PE + PV+ + Sbjct: 1709 T--------------TSEKPP---EQTPETA------MPEPPAPEKPSLLRPVEKEKEKE 1745 Query: 467 M-----EKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGK---KGPRLPEKETLLSL 518 LR E A +R E + +P + P+++ K + P K+ L Sbjct: 1746 KVTRGERPLRGERATSGRQTRPERSLATGQPATSRLPKARPTKVKAEPPPKKRKKWLKEA 1805 Query: 519 PAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIP-QDSPTPSVRQI-RNELEARLSS 576 T G P GSS +++E++P +P + T ++R++ R+ +E +S+ Sbjct: 1806 GGNATAGGGPP----GSS-SDSESSPGAPSEDERAVPGRLLKTRAMREMYRSYVEMLVST 1860 Query: 577 AAEKEAKPSIGS------LPPKPRLEG 597 A + + ++ LPP +++G Sbjct: 1861 ALDPDMIQALEDTHDELYLPPMRKIDG 1887 Score = 89.4 bits (220), Expect = 2e-17 Identities = 237/1031 (22%), Positives = 345/1031 (33%), Gaps = 234/1031 (22%) Query: 140 PPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSP 199 PPPPP A Q P G L + P PL+L PPPP + P + A SP Sbjct: 764 PPPPPPTA----QSTQPTPHGLLLEA----GGPDLPLVLPPPPPQLL---PSVLSHAPSP 812 Query: 200 PHTLSSPSI----PTPPDFIPPAPPLAFLAPPPPPVPAP------------APPAPASPH 243 + S + P D P PP PPPPP P P P AP+ Sbjct: 813 SPSASKVGVHLLEPATRDGAPQPPP----PPPPPPPPMPLQLEAHLRSHGLEPAAPSPRL 868 Query: 244 TVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPA-EPKGSALGPNPE--------- 293 L PPG + + + T PP S +P G+ P+P+ Sbjct: 869 RPEESLDPPGAMQELLGALEPLPPAPGDTGVGPPNSEGKDPAGAYRSPSPQGTKAPRFVP 928 Query: 294 -PHLTFP--------RSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSF 344 + FP RSF P + + P ++EG K P PP++ Sbjct: 929 LTSICFPDSLLQDEERSF-FPTMEEMFGGGAADDYGKAGPPEDEGDPKAGAGPPPGPPAY 987 Query: 345 HIRPASQVYPDRAP-----------EPDCPGELKATAPASPRLGQSQSQADERAGTPPPA 393 P P RA +P+ P EL +T A P LG QS +A PPP Sbjct: 988 D--PYGPYCPGRASGAGPETPGLGLDPNKPPELPSTVNAEP-LGLIQS-GPHQAAPPPPP 1043 Query: 394 PPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPP----- 448 PP PPPA P + P P+ C+ K K K+SS L + +PP Sbjct: 1044 PPPPPPA----PASEPKGGLTSPIFCSTKP-------KKLLKTSSFHLLRRRDPPFQTPK 1092 Query: 449 ---------SPENTASSAPVDWR-DPSQMEKLRNELAAYLCGSRRED-RFLSHRPGPTVA 497 + + P D R +P ++ L + + S D F PGP Sbjct: 1093 KLYAQEYEFEADEDKADVPADIRLNPRRLPDLVSSCRSRPALSPLGDIDFCPPNPGPD-G 1151 Query: 498 PQ------SKEGKKGPRLP---------EKETLLSLPAKDTPP-------------GVPE 529 P+ +K + GP P E T + TP G Sbjct: 1152 PRRRGRKPTKAKRDGPPRPRGRPRIRPLEVPTTAGPASASTPTDGAKKPRGRGRGRGRKA 1211 Query: 530 KSLGGS----------SLTETEAAPSLTLPSVDYIP-QDSPTPSVRQIRNELEARLSSAA 578 + GG+ L+ +A L S D I D + R ++EA++ Sbjct: 1212 EEAGGTRLEPLKPLKIKLSVPKAGEGLGTSSGDAISGTDHNSLDSSLTREKIEAKIKEVE 1271 Query: 579 EKEAKPSIGSLPP-KPRLEGGR----ICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQP 633 EK+ + G + L+ G+ + + G LS P K++PP +P LQP Sbjct: 1272 EKQPEMKSGFMASFLDFLKSGKRHPPLYQAGL-TPPLSPP--KSVPPS----VPARGLQP 1324 Query: 634 KAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATP-------LKATSGPTTPLKAT 686 + PA+ P P A L A LG +P LK + Sbjct: 1325 QPPATPAV-PHPPPSGAFGLGGALEAAESEGLGLGCPSPCKRLDEELKRNLETLPSFSSD 1383 Query: 687 SGPAIASTATTLPTTTSQLMAEKD---------SGPAGQPEKPASQEVSTP-----SQAR 732 ++A + +S + A D S P G P PA+ P A Sbjct: 1384 EEDSVAKNRDLQESISSAISALDDPPLAGPKDTSTPDGPPLAPAAAVPGPPPLPGLPSAN 1443 Query: 733 GEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARG 792 G+P P + PP +P P P Q +L +V PT Sbjct: 1444 SNGTPEP----PLLEEKPPPTPPPAPTPQPQPPP---PPPPPQPALPSPPPLVAPT---- 1492 Query: 793 GAAGPGEPVEVKEPPGLPAKP--------PASAQPTDELLRHPVTGEVVERGSPMALLLA 844 ++ P P+ PP +P+ P P +A P + P E+ + P+ L Sbjct: 1493 PSSPPPPPLPPPPPPAMPSPPPPPPPAAAPLAAPPEEPAAPSPEDPELPDT-RPLHLAKK 1551 Query: 845 ARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSD------SIFHSQGTPNSFTVVPKL 898 A G + A G S G R+ + D ++ + P + V L Sbjct: 1552 QETAAVCGETDEEA-GESGGEGIFRERDEFVIRAEDIPSLKLALQTGREPPPIWRVQKAL 1610 Query: 899 -------PKEAEKDSPLTTEIPNKWGPRLGR-------------DAEGTELSRRHNWTKP 938 K+ ++ T+ +G R + + R W +P Sbjct: 1611 LQKFTPEIKDGQRQFCATSNYLGYFGDAKNRYQRLYVKFLENVNKKDYVRVCARKPWHRP 1670 Query: 939 EPQAPVAWERVAPSNLP-----QGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFS 993 PV R + P P PK+ + PP P + E+ PPE + Sbjct: 1671 ----PVPVRRSGQAKNPVSAGGSSAPPPKAPAPPPKPETPEKTTSEK--------PPEQT 1718 Query: 994 ND---PEPPAP 1001 + PEPPAP Sbjct: 1719 PETAMPEPPAP 1729 Score = 87.0 bits (214), Expect = 9e-17 Identities = 148/590 (25%), Positives = 206/590 (34%), Gaps = 73/590 (12%) Query: 191 PPVLEA-LSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRL 249 PP+ +A L+PP + PP +PP+ P L P PP PA P P+ +G Sbjct: 1296 PPLYQAGLTPPLS--------PPKSVPPSVPARGLQPQPPATPAVPHPPPSGAFGLGG-- 1345 Query: 250 FPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTP 309 AL ++E P SP + L N E T P SF Sbjct: 1346 -------------ALEAAESEGLGLGCP-SPCKRLDEELKRNLE---TLP-SFSSDEEDS 1387 Query: 310 VRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKAT 369 V + + A + P P + PA+ V P P P P Sbjct: 1388 VAKNRDLQESISSAISALDDPPLAGPKDTSTPDGPPLAPAAAV-PGPPPLPGLPSANSNG 1446 Query: 370 APASPRLGQSQSQADERAGTPPPAP-PLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPA 428 P P L + TPPPAP P P P PP PPP P L P+ PPL ++ PP Sbjct: 1447 TPEPPLLEEKPPP------TPPPAPTPQPQPPPPPPPPQPAL-PSPPPLVAPTPSSPPPP 1499 Query: 429 GFTKTPKSSSPALKPKPNPPS------PENTASSAPVD--WRDPSQMEKLRNELAAYLCG 480 P + P+ P P P + PE A+ +P D D + + + A +CG Sbjct: 1500 PLPPPPPPAMPSPPPPPPPAAAPLAAPPEEPAAPSPEDPELPDTRPLHLAKKQETAAVCG 1559 Query: 481 SRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTET 540 E+ S G + + + +P + L + P +K+L E Sbjct: 1560 ETDEEAGESGGEG-IFRERDEFVIRAEDIPSLKLALQTGREPPPIWRVQKALLQKFTPEI 1618 Query: 541 EAAPSLTLPSVDYIPQ--DSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKP-RLEG 597 + + +Y+ D+ R LE + PP P R G Sbjct: 1619 KDGQRQFCATSNYLGYFGDAKNRYQRLYVKFLENVNKKDYVRVCARKPWHRPPVPVRRSG 1678 Query: 598 GRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATL 657 A P A PP+ T TTS +P P A PEP P K +L Sbjct: 1679 QAKNPVSAGGSSAPPPKAPAPPPKPETPEKTTSEKPPEQ----TPETAMPEPPAPEKPSL 1734 Query: 658 W-----PATPPKATLG--PATPLKATSGPTTPLK---ATSGPAIASTATTLPTTTSQLMA 707 K T G P +ATSG T + AT PA + PT ++ A Sbjct: 1735 LRPVEKEKEKEKVTRGERPLRGERATSGRQTRPERSLATGQPATSRLPKARPT---KVKA 1791 Query: 708 EKDSGPAGQPEKPASQEVSTPSQARG--EGSPSEATRLPTQGARSSAAFP 755 E P + K +E + A G GS S++ P + A P Sbjct: 1792 E----PPPKKRKKWLKEAGGNATAGGGPPGSSSDSESSPGAPSEDERAVP 1837 Score = 68.2 bits (165), Expect = 5e-11 Identities = 248/1122 (22%), Positives = 364/1122 (32%), Gaps = 198/1122 (17%) Query: 83 PLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLRLY--SSVGDLRPGQYGQDLLIP 140 P A + GL +PS+ TG S ++G+ + SS+G G+ +I Sbjct: 515 PGPAAHSQGLPTASPSLSYS------TGHSPALSGHGGGWGPSSLGG--GGEASPSHIIR 566 Query: 141 PPPPGPAPGPPQDISEP--PG---GSPLPSPPSTAPPPP-----------------PLLL 178 P PA G P + P PG S L S P APP LL Sbjct: 567 PLQSPPATGRPPGVGSPGAPGKYLSSVLASAPFLAPPGAGSYAAGAGGYKGKGDGSELLA 626 Query: 179 EPPPPPSMAPPPPP-----VLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPA 233 P PP+ +L+A SPP T + + + L P Sbjct: 627 GPGGPPAERTEDEEFLIQHLLQAPSPPRTSGADGLVGEDGAADASKGLGGSGGAGGPPGT 686 Query: 234 PAPPAPASPH------TVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSA 287 P A P + T G T + + L + + + P R P+G A Sbjct: 687 PYELAKEDPQRYHLQSVIRTSASLDEGAT---AALELGLGRLKEKKKGPERGGETPEGLA 743 Query: 288 L-----GPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPP 342 G + F + PPP P S+ P E P LP PP Sbjct: 744 TSVVHYGAGAKELGAFLQK-SPPPPPPTAQSTQPTPHGLLL----EAGGPDLPLVLPPPP 798 Query: 343 SFHIRPASQVYPD---RAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPP 399 Q+ P AP P +P++ ++G + R G P P PP PPP Sbjct: 799 P-------QLLPSVLSHAPSP---------SPSASKVGVHLLEPATRDGAPQPPPPPPPP 842 Query: 400 APPLPPPAPP------LPPAAP-PLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPS--P 450 PP+P L PAAP P +++ PP + + P L P P P Sbjct: 843 PPPMPLQLEAHLRSHGLEPAAPSPRLRPEESLDPPGAMQELLGALEP-LPPAPGDTGVGP 901 Query: 451 ENTASSAPVD-WRDPSQM-----------------EKLRNELAAY------LCGSRREDR 486 N+ P +R PS L++E ++ + G D Sbjct: 902 PNSEGKDPAGAYRSPSPQGTKAPRFVPLTSICFPDSLLQDEERSFFPTMEEMFGGGAADD 961 Query: 487 FLSHRP-----------GPTVAPQSKE-------GKKGPRLPEKETLLSLPAKDTPPGVP 528 + P GP P + + G+ PE L P K PP +P Sbjct: 962 YGKAGPPEDEGDPKAGAGPPPGPPAYDPYGPYCPGRASGAGPETPGLGLDPNK--PPELP 1019 Query: 529 EKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARL--SSAAEKEAKPSI 586 ++ L ++ P P P P P+ + + L + + S+ +K K S Sbjct: 1020 S-TVNAEPLGLIQSGPHQAAPPPPPPPPPPPAPA-SEPKGGLTSPIFCSTKPKKLLKTSS 1077 Query: 587 GSL-----PP--KPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGP 639 L PP P+ + E AD+DK P L P+ L +S + + L P Sbjct: 1078 FHLLRRRDPPFQTPKKLYAQEYEFEADEDKADVPADIRLNPRRLPDL-VSSCRSRPALSP 1136 Query: 640 AIPPKATPEPAIPPKATLWPATPPKATL-GPATPLKATSGPTTPLKATSGPAIASTATT- 697 P P P KA GP P + T+GPA AST T Sbjct: 1137 LGDIDFCPPNPGPDGPRRRGRKPTKAKRDGPPRPRGRPRIRPLEVPTTAGPASASTPTDG 1196 Query: 698 --LPTTTSQ---LMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPS-EATRLPTQGARSS 751 P + AE+ G +P KP ++S P G G+ S +A + S Sbjct: 1197 AKKPRGRGRGRGRKAEEAGGTRLEPLKPLKIKLSVPKAGEGLGTSSGDAISGTDHNSLDS 1256 Query: 752 AAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVM-----PTLARGGAAGPGEPVEVKEP 806 + K EV +P ++ + + P L + G P P + P Sbjct: 1257 SLTREKIEAKIKEVE-EKQPEMKSGFMASFLDFLKSGKRHPPLYQAGLTPPLSPPK-SVP 1314 Query: 807 PGLPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSS--- 863 P +PA+ P + HP G + + S G LG S Sbjct: 1315 PSVPARGLQPQPPATPAVPHPPPSGAFGLGGAL----------EAAESEGLGLGCPSPCK 1364 Query: 864 -----LPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGP 918 L +L + DS+ ++ S + + P T P+ GP Sbjct: 1365 RLDEELKRNLETLPSFSSDEEDSVAKNRDLQESISSAISALDDPPLAGPKDTSTPD--GP 1422 Query: 919 RLGRDAEGTE------LSRRHNWTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSN 972 L A L ++ PEP P+ E+ P+ P P P+ PP P Sbjct: 1423 PLAPAAAVPGPPPLPGLPSANSNGTPEP--PLLEEKPPPTPPPAPTPQPQPPPPPPPPQP 1480 Query: 973 KREEEEEEFNFEVI---------PPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLRQL 1023 PPPP + P PP PA L P + +L Sbjct: 1481 ALPSPPPLVAPTPSSPPPPPLPPPPPPAMPSPPPPPPPAAAPLAAPPEEPAAPSPEDPEL 1540 Query: 1024 PNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKR 1065 P+ P L ++ A G E GG + ++R Sbjct: 1541 PDTRP-----LHLAKKQETAAVCGETDEEAGESGGEGIFRER 1577 Score = 51.2 bits (121), Expect = 6e-06 Identities = 195/899 (21%), Positives = 281/899 (31%), Gaps = 176/899 (19%) Query: 277 PRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPS 336 P S P SAL P R F VP SS+ +Q+ +P P+ Sbjct: 137 PGSSTFPSSSALSAYQHPASFGSRPFPVP-------SSLSLQDPPFSP----------PA 179 Query: 337 RLPLPPS--FHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAP 394 L P H++P+ +AP T P+S LG + G P Sbjct: 180 NGLLSPHDVLHLKPS------QAP----------TVPSS--LGFERLAGGGVLGPAGLGP 221 Query: 395 PLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTA 454 PP P PP PP P H P F SS+ A + + P N + Sbjct: 222 AQTPPYRPGPPDPPPPP------------RHLPTQFNLLASSSAAAAAAEQSSPQLYNFS 269 Query: 455 SSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKE------GKKGPR 508 +AP P + R + + R S +P P P G P Sbjct: 270 GAAPGP--PPPERALPRQDTVI-----KHYQRPASAQPPPPPPPAHALQHYLSCGGSYPS 322 Query: 509 LPEKETLLSLP--AKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQI 566 + + L P + PG E S G S A+ T P + Sbjct: 323 MGHRANLACSPLGGGEPSPGAGEPSKAGPSGATAGASGRATGPEA------AGGGGAGGG 376 Query: 567 RNELEARLSSAAEKEAKPSIGSL------PPKPRLEGGRICENGADDDKLSKPVAKNLPP 620 + S K K G+ PP PR C++ L P A Sbjct: 377 GGGYRPIIQSPGYKTGKGGYGAAAGGATRPPPPRSTATPKCQS------LGGPAAAYATG 430 Query: 621 QSTTL-----LPTTSLQPKAMLGPAIPPKATP--EPAIPPKATLWPATPPKATLGPATPL 673 +++ + QP+ +LGP + + KA + PP+ GP P Sbjct: 431 KASGAGGAGGQAYSPGQPQGLLGPQAYGQGFGGGQAQDLSKAPSYSGGPPQPPSGPPPPG 490 Query: 674 KATSGPTTP---------LKATSGPAIASTATTLPTTTSQLMAEKDSGPA----GQPEKP 720 AT +P ++ P A+ + LPT + L PA G P Sbjct: 491 LATCQSYSPDQLQGQLYGVQGEPYPGPAAHSQGLPTASPSLSYSTGHSPALSGHGGGWGP 550 Query: 721 ASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSR 780 +S GE SPS R P Q ++ P SPG P + SS+ Sbjct: 551 SSLG------GGGEASPSHIIR-PLQSPPATGRPPGVGSPGA--------PGKYLSSVLA 595 Query: 781 EVAVVMPTLA------RGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVE 834 + P A GG G G+ E+ PG P P + + L++H + Sbjct: 596 SAPFLAPPGAGSYAAGAGGYKGKGDGSELLAGPGGP--PAERTEDEEFLIQHLLQAPSPP 653 Query: 835 RGSPMALLLAARQRAQKGRSVGAALGRSSLPGS---------LRDHSHQAEASSDSIFHS 885 R S L+ A + +G + G PG+ R H +S S+ Sbjct: 654 RTSGADGLVGEDGAADASKGLGGSGGAGGPPGTPYELAKEDPQRYHLQSVIRTSASL--D 711 Query: 886 QGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVA 945 +G + + KE +K E P + G + P P P A Sbjct: 712 EGATAALELGLGRLKEKKKGPERGGETPEGLATSVVHYGAGAKELGAFLQKSPPPPPPTA 771 Query: 946 WERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPE------FSNDPEPP 999 S P H L P P V+PPPP S+ P P Sbjct: 772 -----QSTQPTPHGLLLEAGGPDLPL-------------VLPPPPPQLLPSVLSHAPSP- 812 Query: 1000 APALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGR 1059 +P+ +G P Q P P PP + + + GLE + R Sbjct: 813 SPSASKVGVHLLEPATR-DGAPQPPPPPPPPPPPMPLQL----EAHLRSHGLEPAAPSPR 867 Query: 1060 SLIKKRLYVGEPHRGPGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAP 1118 ++ L P G L + P PG + NS G+ P G +P Sbjct: 868 LRPEESLD----------PPGAMQELLGALEPLPPAPGDTGVGPPNSEGKDPAGAYRSP 916 Score = 50.8 bits (120), Expect = 7e-06 Identities = 186/826 (22%), Positives = 262/826 (31%), Gaps = 149/826 (18%) Query: 97 PSVPDDFADKEVTGTSSLVNGNLRLYSSVGDLRPGQYGQDLLIPPPPPGPAP-------- 148 P+VP G L G + + +G + Y PPPPP P Sbjct: 197 PTVPSSL------GFERLAGGGVLGPAGLGPAQTPPYRPGPPDPPPPPRHLPTQFNLLAS 250 Query: 149 ----GPPQDISEPP-----GGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSP 199 + S P G +P P PP A P +++ P+ A PPPP A + Sbjct: 251 SSAAAAAAEQSSPQLYNFSGAAPGPPPPERALPRQDTVIKHYQRPASAQPPPPPPPAHAL 310 Query: 200 PHTLSS----PSIPTPPDFIPPAPPLAFLAPPP-PPVPAPAPPAPASPHTVGTRLFPP-- 252 H LS PS+ + PL P P P+ A P+ A+ G P Sbjct: 311 QHYLSCGGSYPSMGHRANL--ACSPLGGGEPSPGAGEPSKAGPSGATAGASGRATGPEAA 368 Query: 253 ------GGVTKWKSDVALNGRQ----------AEATRASPPRSPAEPKGSALGPNPEPHL 296 GG ++ + G + ATR PPRS A PK +LG + Sbjct: 369 GGGGAGGGGGGYRPIIQSPGYKTGKGGYGAAAGGATRPPPPRSTATPKCQSLGGPAAAYA 428 Query: 297 TFPRS------FKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPAS 350 T S + P + P Q + KAPS PP Sbjct: 429 TGKASGAGGAGGQAYSPGQPQGLLGPQAYGQGFGGGQAQDLSKAPSYSGGPPQ------- 481 Query: 351 QVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPL 410 P P P PG L SP Q Q Q G P P P P P+ Sbjct: 482 ---PPSGPPP--PG-LATCQSYSP--DQLQGQLYGVQGEPYPGPAAHSQGLPTASPSLSY 533 Query: 411 PPAAPPLPCAQKAAHPPAGFTKTPKSS-SPALKPKPNPPSPENTASSAPVDWRDPSQMEK 469 P P+ ++S S ++P +PP A+ P P K Sbjct: 534 STGHSPALSGHGGGWGPSSLGGGGEASPSHIIRPLQSPP-----ATGRPPGVGSPGAPGK 588 Query: 470 LRNELAA------------YLCGS-----RREDRFLSHRPGPTVAPQSKEGK-------K 505 + + A Y G+ + + L PG A ++++ + + Sbjct: 589 YLSSVLASAPFLAPPGAGSYAAGAGGYKGKGDGSELLAGPGGPPAERTEDEEFLIQHLLQ 648 Query: 506 GPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQ 565 P P L +D K LGGS L D PQ SV + Sbjct: 649 APSPPRTSGADGLVGEDGAADA-SKGLGGSGGAGGPPGTPYELAKED--PQRYHLQSVIR 705 Query: 566 IRNELEARLSSAAE------KEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLP 619 L+ ++A E KE K P + GA +L + K+ P Sbjct: 706 TSASLDEGATAALELGLGRLKEKKKGPERGGETPEGLATSVVHYGAGAKELGAFLQKSPP 765 Query: 620 PQSTTLLPTTSLQPKAML----GPAIPPKATPEP--AIPPKATLWPATPPKAT------L 667 P T +T P +L GP +P P P +P + P+ P A+ L Sbjct: 766 PPPPT-AQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASKVGVHLL 824 Query: 668 GPAT------PLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAG------ 715 PAT P P P+ + S + +L E+ P G Sbjct: 825 EPATRDGAPQPPPPPPPPPPPMPLQLEAHLRSHGLEPAAPSPRLRPEESLDPPGAMQELL 884 Query: 716 ---QPEKPASQEVST-PSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKP 771 +P PA + P + G+ P+ A R P+ + F P TS + P Sbjct: 885 GALEPLPPAPGDTGVGPPNSEGK-DPAGAYRSPSPQGTKAPRFVPLTS--------ICFP 935 Query: 772 HCHQSSLSREVAVVMPTLARGGAA---GPGEPVEVKEPPGLPAKPP 814 R M + GGAA G P E + P A PP Sbjct: 936 DSLLQDEERSFFPTMEEMFGGGAADDYGKAGPPEDEGDPKAGAGPP 981 Score = 47.4 bits (111), Expect = 8e-05 Identities = 73/313 (23%), Positives = 98/313 (31%), Gaps = 40/313 (12%) Query: 110 GTSSLVNGNLRLYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPST 169 G S L + L S G P +L+ GP PGP SP Sbjct: 67 GLSGLFDTGLHHAGSAG---PDASVMNLISALESRGPQPGPSASSLLSQFRSPSWQTAMH 123 Query: 170 APPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFI----PPAPPLAFLA 225 P P L + P S P L A P + S P P P +PP L Sbjct: 124 TPGPTELFISGALPGSSTFPSSSALSAYQHPASFGSRPFPVPSSLSLQDPPFSPPANGLL 183 Query: 226 PPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKG 285 P + AP P ++G GGV L Q R PP P P+ Sbjct: 184 SPHDVLHLKPSQAPTVPSSLGFERLAGGGVL---GPAGLGPAQTPPYRPGPPDPPPPPR- 239 Query: 286 SALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPP--- 342 HL P F + + +SS A+++ + + AP P PP Sbjct: 240 ---------HL--PTQFNL-----LASSSAAAAAAEQSSPQLYNFSGAAPG--PPPPERA 281 Query: 343 --------SFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAP 394 + RPAS P P + + P +G + A G P+P Sbjct: 282 LPRQDTVIKHYQRPASAQPPPPPPPAHALQHYLSCGGSYPSMGHRANLACSPLGGGEPSP 341 Query: 395 PLPPPAPPLPPPA 407 P+ P A Sbjct: 342 GAGEPSKAGPSGA 354 Score = 42.4 bits (98), Expect = 0.003 Identities = 66/239 (27%), Positives = 84/239 (35%), Gaps = 44/239 (18%) Query: 950 APSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIP----PPPEFSNDPEPPAPALQ- 1004 A + PQ + + PP P ++ P PPP P PPA ALQ Sbjct: 258 AEQSSPQLYNFSGAAPGPPPPERALPRQDTVIKHYQRPASAQPPP-----PPPPAHALQH 312 Query: 1005 YLGRQSSPPRNNYSDLRQL-------PNAGPGAPPALGFSRFPAGA-------RYAGAGG 1050 YL S P + P+ G G P G S AGA AG GG Sbjct: 313 YLSCGGSYPSMGHRANLACSPLGGGEPSPGAGEPSKAGPSGATAGASGRATGPEAAGGGG 372 Query: 1051 LERFSGGGRSLIKKRLYVGEPHRGPGLPHGGTGR-----SLSSPNCFGPQPGGPEMR--- 1102 GG R +I+ Y G G GG R S ++P C GGP Sbjct: 373 AGGGGGGYRPIIQSPGYK-TGKGGYGAAAGGATRPPPPRSTATPKC--QSLGGPAAAYAT 429 Query: 1103 -RVNSAGRA--------PPGGLHAPRLSLEGAARGAAEAKHKAPGSADYGFAPAAGRSP 1152 + + AG A P GL P+ +G G A+ KAP + P +G P Sbjct: 430 GKASGAGGAGGQAYSPGQPQGLLGPQAYGQGFGGGQAQDLSKAPSYSGGPPQPPSGPPP 488 Score = 34.7 bits (78), Expect = 0.56 Identities = 44/157 (28%), Positives = 52/157 (33%), Gaps = 28/157 (17%) Query: 141 PPPPGPAPGP-PQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLE---- 195 PPP PAP P P+ + P P TA P PP P PS+ P E Sbjct: 1692 PPPKAPAPPPKPETPEKTTSEKPPEQTPETAMPEPP----APEKPSLLRPVEKEKEKEKV 1747 Query: 196 -----------ALSPPHTLSSPSIPT---PPDFIPPAPPLAFLAPPPPPVPAPAPPAPAS 241 A S T S+ T +P A P A PPP Sbjct: 1748 TRGERPLRGERATSGRQTRPERSLATGQPATSRLPKARPTKVKAEPPPKKRKKWLKEAGG 1807 Query: 242 PHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPR 278 T G PPG + +S G +E RA P R Sbjct: 1808 NATAGGG--PPGSSSDSESS---PGAPSEDERAVPGR 1839 Score = 33.9 bits (76), Expect = 0.95 Identities = 43/194 (22%), Positives = 57/194 (29%), Gaps = 52/194 (26%) Query: 141 PPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPP 200 PP P G ++ G S +PP AP PPP +P P PP Sbjct: 1670 PPVPVRRSGQAKNPVSAGGSS---APPPKAPAPPP---KPETPEKTTSEKPP-------- 1715 Query: 201 HTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKS 260 P P PPAP P L P K K Sbjct: 1716 -------------------------EQTPETAMPEPPAPEKP-----SLLRPVEKEKEKE 1745 Query: 261 DVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEA 320 V R RA+ R + A G P + ++P P + + P + Sbjct: 1746 KVTRGERPLRGERATSGRQTRPERSLATGQ--------PATSRLPKARPTKVKAEPPPKK 1797 Query: 321 QEAPRKEEGATKKA 334 ++ KE G A Sbjct: 1798 RKKWLKEAGGNATA 1811 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.309 0.131 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 75,186,076 Number of Sequences: 37866 Number of extensions: 6108069 Number of successful extensions: 166565 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 1439 Number of HSP's successfully gapped in prelim test: 2338 Number of HSP's that attempted gapping in prelim test: 31781 Number of HSP's gapped (non-prelim): 48390 length of query: 1188 length of database: 18,247,518 effective HSP length: 113 effective length of query: 1075 effective length of database: 13,968,660 effective search space: 15016309500 effective search space used: 15016309500 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.7 bits) S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.