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Search of human proteins with 229892300
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|229892300 fms-related tyrosine kinase 1 isoform 3 precursor
[Homo sapiens]
(733 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|229892300 fms-related tyrosine kinase 1 isoform 3 precursor [... 1472 0.0
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [... 1425 0.0
gi|229892220 fms-related tyrosine kinase 1 isoform 2 precursor [... 1322 0.0
gi|229892302 fms-related tyrosine kinase 1 isoform 4 precursor [... 1049 0.0
gi|11321597 kinase insert domain receptor precursor [Homo sapiens] 366 e-101
gi|104294888 fms-related tyrosine kinase 4 isoform 1 precursor [... 361 1e-99
gi|103472027 fms-related tyrosine kinase 4 isoform 2 precursor [... 361 1e-99
gi|5453870 platelet-derived growth factor receptor alpha precurs... 147 4e-35
gi|4505683 platelet-derived growth factor receptor beta precurso... 108 2e-23
gi|118572606 hemicentin 1 [Homo sapiens] 102 1e-21
gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge... 93 8e-19
gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene... 93 8e-19
gi|5453872 platelet-derived growth factor receptor-like protein ... 92 2e-18
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens] 91 4e-18
gi|7657359 contactin 5 isoform long [Homo sapiens] 88 3e-17
gi|28373129 contactin 5 isoform short [Homo sapiens] 88 3e-17
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 86 2e-16
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 86 2e-16
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 86 2e-16
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 85 2e-16
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 85 2e-16
gi|19743806 roundabout 1 isoform b [Homo sapiens] 85 3e-16
gi|4506569 roundabout 1 isoform a [Homo sapiens] 85 3e-16
gi|110349719 titin isoform N2-A [Homo sapiens] 83 1e-15
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 81 3e-15
gi|224994173 roundabout 1 isoform d [Homo sapiens] 80 5e-15
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 79 1e-14
gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo sapi... 77 7e-14
gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo sap... 77 7e-14
gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo sap... 74 4e-13
>gi|229892300 fms-related tyrosine kinase 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 1472 bits (3812), Expect = 0.0
Identities = 733/733 (100%), Positives = 733/733 (100%)
Query: 1 MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK 60
MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK
Sbjct: 1 MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK 60
Query: 61 WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET 120
WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET
Sbjct: 61 WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET 120
Query: 121 ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD 180
ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD
Sbjct: 121 ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD 180
Query: 181 GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV 240
GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV
Sbjct: 181 GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV 240
Query: 241 KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK
Sbjct: 241 KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
Query: 301 MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK 360
MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK
Sbjct: 301 MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK 360
Query: 361 AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA 420
AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA
Sbjct: 361 AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA 420
Query: 421 TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC 480
TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC
Sbjct: 421 TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC 480
Query: 481 DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK 540
DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK
Sbjct: 481 DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK 540
Query: 541 VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM 600
VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM
Sbjct: 541 VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM 600
Query: 601 HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEA 660
HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEA
Sbjct: 601 HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEA 660
Query: 661 PYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPELYTSTSPSSSSSSP 720
PYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPELYTSTSPSSSSSSP
Sbjct: 661 PYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPELYTSTSPSSSSSSP 720
Query: 721 LSSSSSSSSSSSS 733
LSSSSSSSSSSSS
Sbjct: 721 LSSSSSSSSSSSS 733
>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor
[Homo sapiens]
Length = 1338
Score = 1425 bits (3689), Expect = 0.0
Identities = 706/715 (98%), Positives = 708/715 (99%)
Query: 1 MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK 60
MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK
Sbjct: 1 MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK 60
Query: 61 WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET 120
WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET
Sbjct: 61 WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET 120
Query: 121 ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD 180
ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD
Sbjct: 121 ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD 180
Query: 181 GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV 240
GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV
Sbjct: 181 GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV 240
Query: 241 KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK
Sbjct: 241 KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
Query: 301 MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK 360
MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK
Sbjct: 301 MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK 360
Query: 361 AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA 420
AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA
Sbjct: 361 AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA 420
Query: 421 TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC 480
TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC
Sbjct: 421 TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC 480
Query: 481 DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK 540
DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK
Sbjct: 481 DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK 540
Query: 541 VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM 600
VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM
Sbjct: 541 VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM 600
Query: 601 HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEA 660
HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEA
Sbjct: 601 HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEA 660
Query: 661 PYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPELYTSTSPSS 715
PYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEP + S+
Sbjct: 661 PYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPGIILGPGSST 715
Score = 49.7 bits (117), Expect = 1e-05
Identities = 50/169 (29%), Positives = 69/169 (40%), Gaps = 19/169 (11%)
Query: 245 GHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSV---LTIDKM 301
G L L+CT L V TW N R ++ I + +S+ LTI +
Sbjct: 570 GEDLKLSCTVNKFLYRDV--TWILLRTVNNR-TMHYSISKQKMAITKEHSITLNLTIMNV 626
Query: 302 QNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVL------ETVAGKRSYRL 355
+D G Y CR R+ V T I K IT++ ++ L TVA S L
Sbjct: 627 SLQDSGTYACRARN------VYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTL 680
Query: 356 SMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYS-LIIKDVTEEDAGNY 403
P P++ W K+ ++ L G S L I+ VTEED G Y
Sbjct: 681 DCHANGVPEPQITWFKNNHKIQQEPGIILGPGSSTLFIERVTEEDEGVY 729
Score = 34.3 bits (77), Expect = 0.42
Identities = 58/277 (20%), Positives = 108/277 (38%), Gaps = 45/277 (16%)
Query: 75 SITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRP 134
SIT+ GK ++ TL A + +G Y C + ++K I +I+D
Sbjct: 504 SITQRMAIIEGKNKMAS-TLVVADSRISGIYIC----IASNKVGTVGRNISFYITDVPNG 558
Query: 135 FVEMYSEIPEIIHMTEGRELVIPCRVTS---PNITV----TLKKFPLDTLIPDGKRIIWD 187
F ++P TEG +L + C V ++T T+ + I K I
Sbjct: 559 FHVNLEKMP-----TEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITK 613
Query: 188 SRK---GFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLR 244
I N + ++ G C A ++Y + ++ TI D + P ++ L
Sbjct: 614 EHSITLNLTIMNVSLQDSGTYACRAR---NVYTGEEILQKKEITIRDQE--APYLLRNLS 668
Query: 245 GHTLVLNCTATTPLNTR----VQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
HT+ ++ + T + Q+TW + N + I + +F I++
Sbjct: 669 DHTVAISSSTTLDCHANGVPEPQITWF---KNNHKIQQEPGIILGPGSSTLF-----IER 720
Query: 301 MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVK 337
+ +D+G+Y C K+ N + A++TV+
Sbjct: 721 VTEEDEGVYHC--------KATNQKGSVESSAYLTVQ 749
>gi|229892220 fms-related tyrosine kinase 1 isoform 2 precursor
[Homo sapiens]
Length = 687
Score = 1322 bits (3422), Expect = 0.0
Identities = 656/658 (99%), Positives = 657/658 (99%)
Query: 1 MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK 60
MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK
Sbjct: 1 MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK 60
Query: 61 WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET 120
WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET
Sbjct: 61 WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET 120
Query: 121 ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD 180
ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD
Sbjct: 121 ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD 180
Query: 181 GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV 240
GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV
Sbjct: 181 GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV 240
Query: 241 KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK
Sbjct: 241 KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
Query: 301 MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK 360
MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK
Sbjct: 301 MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK 360
Query: 361 AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA 420
AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA
Sbjct: 361 AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA 420
Query: 421 TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC 480
TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC
Sbjct: 421 TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC 480
Query: 481 DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK 540
DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK
Sbjct: 481 DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK 540
Query: 541 VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM 600
VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM
Sbjct: 541 VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM 600
Query: 601 HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQ 658
HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIR +
Sbjct: 601 HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRGE 658
Score = 47.4 bits (111), Expect = 5e-05
Identities = 98/489 (20%), Positives = 179/489 (36%), Gaps = 85/489 (17%)
Query: 239 PVKLLRGHTLVLNCTATTPLNTRVQMT--WSYPDEKNKRASVRRRIDQSNSHAN--IFYS 294
P L+G ++ T L R + WS P+ +K S R I +S N F S
Sbjct: 32 PELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSKE-SERLSITKSACGRNGKQFCS 90
Query: 295 VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIY------DKAFITVKHRKQQVLETVA 348
LT++ Q G Y+C+ + P+ K T IY + F+ + +++
Sbjct: 91 TLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTE 150
Query: 349 GKR--------SYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDA 400
G+ S +++ +K FP ++ DG S + II + T ++
Sbjct: 151 GRELVIPCRVTSPNITVTLKKFPLDTLI--PDGKRIIWDSRK------GFIISNATYKEI 202
Query: 401 GNYTILLSIK----QSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTA 456
G T ++ ++N + I++V+ S P P G +L CTA
Sbjct: 203 GLLTCEATVNGHLYKTNYLTHRQTNTIIDVQ--------ISTPRPVKLLRGHTLVLNCTA 254
Query: 457 YGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKN 516
++ W + + A ++ RI+ I
Sbjct: 255 TTPLNTRVQMTWSYPDEKNKRA------------------SVRRRIDQSNSHANIFYS-- 294
Query: 517 KMASTLVVADSRISGIYICIASNKVGTVGRNISFYITD-----VPNGFHVNLEKMPTEGE 571
T+ ++ G+Y C + N S +I D V + LE + +
Sbjct: 295 --VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGK-R 351
Query: 572 DLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDS 631
+LS V F +V W+ + + K +T+ +S L I +V+ +D+
Sbjct: 352 SYRLSMKVKAFPSPEVVWL-------KDGLPATEKSARYLTRGYS----LIIKDVTEEDA 400
Query: 632 GTY----ACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTV-AISSSTTLDCHANG 686
G Y + + NV+ + + + ++ Q + + D + + S L C A G
Sbjct: 401 GNYTILLSIKQSNVF--KNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYG 458
Query: 687 VPEPQITWF 695
+P+P I WF
Sbjct: 459 IPQPTIKWF 467
Score = 38.5 bits (88), Expect = 0.022
Identities = 38/137 (27%), Positives = 54/137 (39%), Gaps = 18/137 (13%)
Query: 570 GEDLKLSCTVNKFLYRDV--TWILLRTVNNR-TMHYSISKQKMAITKEHSITLNLTIMNV 626
G L L+CT L V TW N R ++ I + +S+ LTI +
Sbjct: 245 GHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSV---LTIDKM 301
Query: 627 SLQDSGTYACRARN------VYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTL 680
+D G Y CR R+ V T I K IT++ ++ L TVA S L
Sbjct: 302 QNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVL------ETVAGKRSYRL 355
Query: 681 DCHANGVPEPQITWFKN 697
P P++ W K+
Sbjct: 356 SMKVKAFPSPEVVWLKD 372
>gi|229892302 fms-related tyrosine kinase 1 isoform 4 precursor
[Homo sapiens]
Length = 541
Score = 1049 bits (2713), Expect = 0.0
Identities = 517/518 (99%), Positives = 518/518 (100%)
Query: 1 MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK 60
MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK
Sbjct: 1 MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK 60
Query: 61 WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET 120
WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET
Sbjct: 61 WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET 120
Query: 121 ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD 180
ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD
Sbjct: 121 ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD 180
Query: 181 GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV 240
GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV
Sbjct: 181 GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV 240
Query: 241 KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK
Sbjct: 241 KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
Query: 301 MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK 360
MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK
Sbjct: 301 MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK 360
Query: 361 AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA 420
AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA
Sbjct: 361 AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA 420
Query: 421 TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC 480
TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC
Sbjct: 421 TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC 480
Query: 481 DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKM 518
DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNK+
Sbjct: 481 DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKL 518
Score = 47.4 bits (111), Expect = 5e-05
Identities = 98/489 (20%), Positives = 179/489 (36%), Gaps = 85/489 (17%)
Query: 239 PVKLLRGHTLVLNCTATTPLNTRVQMT--WSYPDEKNKRASVRRRIDQSNSHAN--IFYS 294
P L+G ++ T L R + WS P+ +K S R I +S N F S
Sbjct: 32 PELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSKE-SERLSITKSACGRNGKQFCS 90
Query: 295 VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIY------DKAFITVKHRKQQVLETVA 348
LT++ Q G Y+C+ + P+ K T IY + F+ + +++
Sbjct: 91 TLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTE 150
Query: 349 GKR--------SYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDA 400
G+ S +++ +K FP ++ DG S + II + T ++
Sbjct: 151 GRELVIPCRVTSPNITVTLKKFPLDTLI--PDGKRIIWDSRK------GFIISNATYKEI 202
Query: 401 GNYTILLSIK----QSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTA 456
G T ++ ++N + I++V+ S P P G +L CTA
Sbjct: 203 GLLTCEATVNGHLYKTNYLTHRQTNTIIDVQ--------ISTPRPVKLLRGHTLVLNCTA 254
Query: 457 YGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKN 516
++ W + + A ++ RI+ I
Sbjct: 255 TTPLNTRVQMTWSYPDEKNKRA------------------SVRRRIDQSNSHANIFYS-- 294
Query: 517 KMASTLVVADSRISGIYICIASNKVGTVGRNISFYITD-----VPNGFHVNLEKMPTEGE 571
T+ ++ G+Y C + N S +I D V + LE + +
Sbjct: 295 --VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGK-R 351
Query: 572 DLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDS 631
+LS V F +V W+ + + K +T+ +S L I +V+ +D+
Sbjct: 352 SYRLSMKVKAFPSPEVVWL-------KDGLPATEKSARYLTRGYS----LIIKDVTEEDA 400
Query: 632 GTY----ACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTV-AISSSTTLDCHANG 686
G Y + + NV+ + + + ++ Q + + D + + S L C A G
Sbjct: 401 GNYTILLSIKQSNVF--KNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYG 458
Query: 687 VPEPQITWF 695
+P+P I WF
Sbjct: 459 IPQPTIKWF 467
Score = 38.5 bits (88), Expect = 0.022
Identities = 38/137 (27%), Positives = 54/137 (39%), Gaps = 18/137 (13%)
Query: 570 GEDLKLSCTVNKFLYRDV--TWILLRTVNNR-TMHYSISKQKMAITKEHSITLNLTIMNV 626
G L L+CT L V TW N R ++ I + +S+ LTI +
Sbjct: 245 GHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSV---LTIDKM 301
Query: 627 SLQDSGTYACRAR------NVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTL 680
+D G Y CR R +V T I K IT++ ++ L TVA S L
Sbjct: 302 QNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVL------ETVAGKRSYRL 355
Query: 681 DCHANGVPEPQITWFKN 697
P P++ W K+
Sbjct: 356 SMKVKAFPSPEVVWLKD 372
>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
Length = 1356
Score = 366 bits (940), Expect = e-101
Identities = 240/721 (33%), Positives = 368/721 (51%), Gaps = 41/721 (5%)
Query: 9 VLLCALLSCLLLTGSSSGS---KLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPE 65
+L AL C+ +S G L P LS++ ++A TL + CRG+ W P
Sbjct: 6 LLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPN 65
Query: 66 MVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIY 125
S +R+ +T+ + G FC TLT+ N TG Y C Y ++ + S IY
Sbjct: 66 NQSGSEQRVEVTECSDGL----FCKTLTIPKVIGNDTGAYKCFY------RETDLASVIY 115
Query: 126 IFISDTGRPFVEMYSEIPEIIHMTEGRE--LVIPCRVTSPNITVTL-KKFPLDTLIPDGK 182
+++ D PF+ S+ ++++TE + +VIPC + N+ V+L ++P +PDG
Sbjct: 116 VYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGN 175
Query: 183 RIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKT-NYLTHRQTNTIIDVQISTPRPVK 241
RI WDS+KGF I + G++ CEA +N Y++ Y+ I DV +S ++
Sbjct: 176 RISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIE 235
Query: 242 LLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRI--DQSNSHANIFYSVLTID 299
L G LVLNCTA T LN + W YP K++ + R QS S F S LTID
Sbjct: 236 LSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTID 295
Query: 300 KMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKV 359
+ D+GLYTC SG K +T V +++K F+ + ++E G+R R+ K
Sbjct: 296 GVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGER-VRIPAKY 354
Query: 360 KAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLT 419
+P PE+ W K+G+P +S + G+ L I +V+E D GNYT++L+ S ++
Sbjct: 355 LGYPPPEIKWYKNGIPL--ESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHV 412
Query: 420 ATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPT-IKWFWH---PCNHNH 475
+L+V V PQI EK++ S D Y G+ Q LTCT Y IP P I W+W C +
Sbjct: 413 VSLVVYVPPQIGEKSLISPVDS--YQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEP 470
Query: 476 SEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYIC 535
S+A E + D GN+IE + A+IEGKNK STLV+ + +S +Y C
Sbjct: 471 SQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKC 530
Query: 536 IASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRT- 594
A NKVG R ISF++T P + + PTE E + L CT ++ + ++TW L
Sbjct: 531 EAVNKVGRGERVISFHVTRGPE-ITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQ 589
Query: 595 ---VNNRTMHYSISKQ-----KMAITKEHSITLNLTIM---NVSLQDSGTYACRARNVYT 643
++ + + K K+ T + T ++ IM N SLQD G Y C A++ T
Sbjct: 590 PLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKT 649
Query: 644 GEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQ 703
+ +++T+ ++ AP + NL + T +I S + C A+G P PQI WFK+N + +
Sbjct: 650 KKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVE 709
Query: 704 E 704
+
Sbjct: 710 D 710
Score = 35.8 bits (81), Expect = 0.15
Identities = 31/123 (25%), Positives = 54/123 (43%), Gaps = 7/123 (5%)
Query: 285 SNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKS--VNTSVHIYDKAFITVKHRKQQ 342
SNS +I ++ + +D+G Y C + + K V + + ++ T+ +
Sbjct: 618 SNSTNDIL--IMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLEN 675
Query: 343 VLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRG-YSLIIKDVTEEDAG 401
+T + S +S P P+++W KD E S L G +L I+ V +ED G
Sbjct: 676 --QTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEG 733
Query: 402 NYT 404
YT
Sbjct: 734 LYT 736
Score = 34.7 bits (78), Expect = 0.32
Identities = 51/215 (23%), Positives = 79/215 (36%), Gaps = 43/215 (20%)
Query: 441 PALYPLGSRQI-LTCTAYGIPQPTIKWFW---HPCNHNHSEARCDFCSNNEESFILDADS 496
P + P + L CTA + W+ P + E C N + + L+A
Sbjct: 557 PDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNA-- 614
Query: 497 NMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASN----KVGTVGRNISFYI 552
+ T + I+E KN A + G Y+C+A + K V R ++
Sbjct: 615 ---TMFSNSTNDILIMELKN--------ASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLE 663
Query: 553 TDVPNGFHVNLEKMPTE-GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAI 611
P NLE T GE +++SCT + + W K +
Sbjct: 664 RVAPT-ITGNLENQTTSIGESIEVSCTASGNPPPQIMWF---------------KDNETL 707
Query: 612 TKEHSITL-----NLTIMNVSLQDSGTYACRARNV 641
++ I L NLTI V +D G Y C+A +V
Sbjct: 708 VEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSV 742
>gi|104294888 fms-related tyrosine kinase 4 isoform 1 precursor
[Homo sapiens]
Length = 1363
Score = 361 bits (927), Expect = 1e-99
Identities = 225/740 (30%), Positives = 370/740 (50%), Gaps = 65/740 (8%)
Query: 8 GVLLCALL-SCL-LLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWS--- 62
G LC L CL LL G SG + P L++ H++ G +L + CRG+ +W+
Sbjct: 4 GAALCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAWPG 63
Query: 63 ---LPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKE 119
P K+SE + + G + + +C L L+ AN TG Y C Y + +
Sbjct: 64 AQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGT 123
Query: 120 TESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIP 179
T ++ Y+F+ D +PF+ P+ + + + +PC V+ P + VTL+ L P
Sbjct: 124 TAASSYVFVRDFEQPFINK----PDTLLVNRKDAMWVPCLVSIPGLNVTLRS-QSSVLWP 178
Query: 180 DGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTN-YLTHRQTNTIIDVQISTPR 238
DG+ ++WD R+G ++S + L CE T + +N +L H N + D+Q+ +
Sbjct: 179 DGQEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRK 238
Query: 239 PVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRAS--VRRRIDQSNSHANIFYSVL 296
++LL G LVLNCT N+ V W YP ++ +R RR Q+++ + S+L
Sbjct: 239 SLELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELS---SIL 295
Query: 297 TIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLS 356
TI + D G Y C+ +G +T V +++ FI+V+ K +LE AG +L
Sbjct: 296 TIHNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLP 355
Query: 357 MKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFK 416
+K+ A+P PE W KDG + + + + +L++K+VTE G YT+ L + + +
Sbjct: 356 VKLAAYPPPEFQWYKDGKALSGRHSPH-----ALVLKEVTEASTGTYTLALWNSAAGLRR 410
Query: 417 NLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQP-TIKWFWHPCNHNH 475
N++ L+VNV PQI+EK SS P++Y SRQ LTCTAYG+P P +I+W W P
Sbjct: 411 NISLELVVNVPPQIHEKEASS---PSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCK 467
Query: 476 SEARCDFCSNNEESFILDA-------DSNMGNRIESITQRMAIIEGKNKMASTLVVADSR 528
A+ ++ + + N IES+ +EGKNK S LV+ ++
Sbjct: 468 MFAQRSLRRRQQQDLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVIQNAN 527
Query: 529 ISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPT----EGEDLKLSCTVNKFLY 584
+S +Y C+ SNKVG R I FY+T +P+GF +E P+ EG+ + LSC + + Y
Sbjct: 528 VSAMYKCVVSNKVGQDERLIYFYVTTIPDGF--TIESKPSEELLEGQPVLLSCQADSYKY 585
Query: 585 RDVTWILLRTVNNRTMH--------------------YSISKQKMAITKEHSITLNLTIM 624
+ W L N T+H + S +++A H+ TL+L+I
Sbjct: 586 EHLRWYRL---NLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHA-TLSLSIP 641
Query: 625 NVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHA 684
V+ + G Y C ++ + ++ KK ++++ EAP L +NL+D V +S S + C
Sbjct: 642 RVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLV 701
Query: 685 NGVPEPQITWFKNNHKIQQE 704
G P I W+K+ ++++
Sbjct: 702 AGAHAPSIVWYKDERLLEEK 721
Score = 33.5 bits (75), Expect = 0.72
Identities = 34/130 (26%), Positives = 54/130 (41%), Gaps = 3/130 (2%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
L+I ++ + +G Y C V+ S ++ +A + + V S +
Sbjct: 638 LSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEM 697
Query: 356 SMKVKAFPSPEVVWLKDGLPATEKSARYLT-RGYSLIIKDVTEEDAGNYTILLSIKQSNV 414
V +P +VW KD EKS L L I+ V EEDAG Y L S+ +
Sbjct: 698 QCLVAGAHAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDAGRY--LCSVCNAKG 755
Query: 415 FKNLTATLIV 424
N +A++ V
Sbjct: 756 CVNSSASVAV 765
>gi|103472027 fms-related tyrosine kinase 4 isoform 2 precursor
[Homo sapiens]
Length = 1298
Score = 361 bits (927), Expect = 1e-99
Identities = 225/740 (30%), Positives = 370/740 (50%), Gaps = 65/740 (8%)
Query: 8 GVLLCALL-SCL-LLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWS--- 62
G LC L CL LL G SG + P L++ H++ G +L + CRG+ +W+
Sbjct: 4 GAALCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAWPG 63
Query: 63 ---LPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKE 119
P K+SE + + G + + +C L L+ AN TG Y C Y + +
Sbjct: 64 AQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGT 123
Query: 120 TESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIP 179
T ++ Y+F+ D +PF+ P+ + + + +PC V+ P + VTL+ L P
Sbjct: 124 TAASSYVFVRDFEQPFINK----PDTLLVNRKDAMWVPCLVSIPGLNVTLRS-QSSVLWP 178
Query: 180 DGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTN-YLTHRQTNTIIDVQISTPR 238
DG+ ++WD R+G ++S + L CE T + +N +L H N + D+Q+ +
Sbjct: 179 DGQEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRK 238
Query: 239 PVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRAS--VRRRIDQSNSHANIFYSVL 296
++LL G LVLNCT N+ V W YP ++ +R RR Q+++ + S+L
Sbjct: 239 SLELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELS---SIL 295
Query: 297 TIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLS 356
TI + D G Y C+ +G +T V +++ FI+V+ K +LE AG +L
Sbjct: 296 TIHNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLP 355
Query: 357 MKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFK 416
+K+ A+P PE W KDG + + + + +L++K+VTE G YT+ L + + +
Sbjct: 356 VKLAAYPPPEFQWYKDGKALSGRHSPH-----ALVLKEVTEASTGTYTLALWNSAAGLRR 410
Query: 417 NLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQP-TIKWFWHPCNHNH 475
N++ L+VNV PQI+EK SS P++Y SRQ LTCTAYG+P P +I+W W P
Sbjct: 411 NISLELVVNVPPQIHEKEASS---PSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCK 467
Query: 476 SEARCDFCSNNEESFILDA-------DSNMGNRIESITQRMAIIEGKNKMASTLVVADSR 528
A+ ++ + + N IES+ +EGKNK S LV+ ++
Sbjct: 468 MFAQRSLRRRQQQDLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVIQNAN 527
Query: 529 ISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPT----EGEDLKLSCTVNKFLY 584
+S +Y C+ SNKVG R I FY+T +P+GF +E P+ EG+ + LSC + + Y
Sbjct: 528 VSAMYKCVVSNKVGQDERLIYFYVTTIPDGF--TIESKPSEELLEGQPVLLSCQADSYKY 585
Query: 585 RDVTWILLRTVNNRTMH--------------------YSISKQKMAITKEHSITLNLTIM 624
+ W L N T+H + S +++A H+ TL+L+I
Sbjct: 586 EHLRWYRL---NLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHA-TLSLSIP 641
Query: 625 NVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHA 684
V+ + G Y C ++ + ++ KK ++++ EAP L +NL+D V +S S + C
Sbjct: 642 RVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLV 701
Query: 685 NGVPEPQITWFKNNHKIQQE 704
G P I W+K+ ++++
Sbjct: 702 AGAHAPSIVWYKDERLLEEK 721
Score = 33.5 bits (75), Expect = 0.72
Identities = 34/130 (26%), Positives = 54/130 (41%), Gaps = 3/130 (2%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
L+I ++ + +G Y C V+ S ++ +A + + V S +
Sbjct: 638 LSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEM 697
Query: 356 SMKVKAFPSPEVVWLKDGLPATEKSARYLT-RGYSLIIKDVTEEDAGNYTILLSIKQSNV 414
V +P +VW KD EKS L L I+ V EEDAG Y L S+ +
Sbjct: 698 QCLVAGAHAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDAGRY--LCSVCNAKG 755
Query: 415 FKNLTATLIV 424
N +A++ V
Sbjct: 756 CVNSSASVAV 765
>gi|5453870 platelet-derived growth factor receptor alpha precursor
[Homo sapiens]
Length = 1089
Score = 147 bits (370), Expect = 4e-35
Identities = 155/557 (27%), Positives = 242/557 (43%), Gaps = 74/557 (13%)
Query: 14 LLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSKESER 73
+L CLL S +L P + + ++Q + L+C GE+ W P M +ES
Sbjct: 10 VLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP-MSEEESSD 68
Query: 74 LSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGR 133
+ I N F + L +++A A HTG Y+C Y T + + IYI++ D
Sbjct: 69 VEIRNEE--NNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDV 126
Query: 134 PFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFI 193
FV + ++ + + +IPCR T P VTL + ++P +DSR+GF
Sbjct: 127 AFVPL-GMTDYLVIVEDDDSAIIPCRTTDPETPVTLHN--SEGVVPAS----YDSRQGF- 178
Query: 194 ISNATYKEIGLLTCEATVNGHLYKT---NYLTHRQTNTIIDVQISTPRPVKLLRGHTLVL 250
N T+ +G CEATV G ++T N + T+ +D+++ + V G T+V+
Sbjct: 179 --NGTF-TVGPYICEATVKGKKFQTIPFNVYALKATSE-LDLEMEALKTV-YKSGETIVV 233
Query: 251 NCTATTPLNTRVQMTWSYPDE-KNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLY 309
C N V + W+YP E K K ++ I + + Y+ LT+ + KD G Y
Sbjct: 234 TCAVFN--NEVVDLQWTYPGEVKGKGITMLEEIKVPS--IKLVYT-LTVPEATVKDSGDY 288
Query: 310 TCRVRSG----PSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSP 365
C R K V SVH +K FI +K Q LE V ++V+A+P P
Sbjct: 289 ECAARQATREVKEMKKVTISVH--EKGFIEIKPTFSQ-LEAVNLHEVKHFVVEVRAYPPP 345
Query: 366 EVVWLKDGLPATEKSARYLT----------RGYSLIIKDVTEEDAGNYTILLSIKQSNVF 415
+ WLK+ L E T R +I+ EED+G+YTI+ + +
Sbjct: 346 RISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIR-AKEEDSGHYTIV--AQNEDAV 402
Query: 416 KNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNH 475
K+ T L+ V I + + Q + CTA G P P I+W C
Sbjct: 403 KSYTFELLTQVPSSILDLVDDH------HGSTGGQTVRCTAEGTPLPDIEWM--ICK--- 451
Query: 476 SEARCDFCSNNEESFILDADSNMGNRIESITQR-MAIIEGK---NKMASTLVVADSRISG 531
+C NNE S+ + A +N+ N I I R + +EG+ K+ T+ V
Sbjct: 452 DIKKC----NNETSWTILA-NNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVR------ 500
Query: 532 IYICIASNKVGTVGRNI 548
C+A N +G R +
Sbjct: 501 ---CLAKNLLGAENREL 514
Score = 42.7 bits (99), Expect = 0.001
Identities = 42/176 (23%), Positives = 72/176 (40%), Gaps = 15/176 (8%)
Query: 531 GIYICIASNKVGTVGRNISF--YITDVPNGFHVNLEKMPT---EGEDLKLSCTVNKFLYR 585
G YIC A+ K G + I F Y + + +E + T GE + ++C V
Sbjct: 185 GPYICEATVK-GKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNNEVV 243
Query: 586 DVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGE 645
D+ W V + I+ + + LT+ +++DSG Y C AR
Sbjct: 244 DLQWTYPGEVKGK----GITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQ--ATR 297
Query: 646 EILQKKEITIRDQEAPYL-LRNLSDHTVAISSSTT--LDCHANGVPEPQITWFKNN 698
E+ + K++TI E ++ ++ A++ P P+I+W KNN
Sbjct: 298 EVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNN 353
Score = 41.2 bits (95), Expect = 0.003
Identities = 96/489 (19%), Positives = 182/489 (37%), Gaps = 82/489 (16%)
Query: 228 TIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNS 287
++I Q+S P + + LN + + +++W YP + + + V R +++NS
Sbjct: 19 SLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNS 78
Query: 288 HANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIY------DKAFITVKHRKQ 341
+F +VL + GLYTC + ++ HIY D AF+ +
Sbjct: 79 --GLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDY 136
Query: 342 QVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAG 401
V+ V S + + +P + +G+ +R +G++ G
Sbjct: 137 LVI--VEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSR---QGFN-----------G 180
Query: 402 NYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPD------PALYPLGSRQILTCT 455
+T+ I ++ V T+ NV Y +S D +Y G ++TC
Sbjct: 181 TFTVGPYICEATVKGKKFQTIPFNV----YALKATSELDLEMEALKTVYKSGETIVVTCA 236
Query: 456 AYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGK 515
+ ++W + E + + EE ++ SI
Sbjct: 237 VFNNEVVDLQWTYP------GEVKGKGITMLEEI-----------KVPSI---------- 269
Query: 516 NKMASTLVVADSRI--SGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDL 573
K+ TL V ++ + SG Y C A V I+ GF + ++ ++ E +
Sbjct: 270 -KLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGF-IEIKPTFSQLEAV 327
Query: 574 KLS------CTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLN--LTIMN 625
L V + ++W+ NN T+ ++++ + K I L ++
Sbjct: 328 NLHEVKHFVVEVRAYPPPRISWLK----NNLTLIENLTEITTDVEKIQEIRYRSKLKLIR 383
Query: 626 VSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHAN 685
+DSG Y A+N E+ ++ + Q +L + DH + + T+ C A
Sbjct: 384 AKEEDSGHYTIVAQN----EDAVKSYTFELLTQVPSSILDLVDDHHGS-TGGQTVRCTAE 438
Query: 686 GVPEPQITW 694
G P P I W
Sbjct: 439 GTPLPDIEW 447
>gi|4505683 platelet-derived growth factor receptor beta precursor
[Homo sapiens]
Length = 1106
Score = 108 bits (269), Expect = 2e-23
Identities = 127/478 (26%), Positives = 205/478 (42%), Gaps = 62/478 (12%)
Query: 8 GVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMV 67
G LL L LL S G + P G + ++ T L C G A W E +
Sbjct: 14 GELLLLSLLLLLEPQISQGLVVTPP-----GPELVLNVSSTFVLTCSGSAPVVW---ERM 65
Query: 68 SKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESA--IY 125
S+E + + A ++G F S LTL TG Y C + S+ ET+ +Y
Sbjct: 66 SQEPPQ----EMAKAQDGT-FSSVLTLTNLTGLDTGEYFCTH---NDSRGLETDERKRLY 117
Query: 126 IFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRII 185
IF+ D F+ +E I +TE E+ IPCRVT P + VTL + D +P +
Sbjct: 118 IFVPDPTVGFLPNDAE-ELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALP----VP 172
Query: 186 WDSRKGF--IISNATYKEIGLLTCEATVNGHLYKTN-YLTHRQTNTIIDVQISTPRPVKL 242
+D ++GF I + +Y C+ T+ ++ Y +R + I+V ++ + V +
Sbjct: 173 YDHQRGFSGIFEDRSY------ICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTV-V 225
Query: 243 LRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQ 302
+G + L C N V W+YP +++ R V D S+L I +
Sbjct: 226 RQGENITLMCIVIG--NEVVNFEWTYPRKESGRL-VEPVTDFLLDMPYHIRSILHIPSAE 282
Query: 303 NKDKGLYTCRVRSG----PSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMK 358
+D G YTC V K++N + + + ++ + + L+ RS L +
Sbjct: 283 LEDSGTYTCNVTESVNDHQDEKAIN--ITVVESGYVRLL-GEVGTLQFAELHRSRTLQVV 339
Query: 359 VKAFPSPEVVWLKDGLPATEKSARYL---TRGYS-------LIIKDVTEEDAGNYTILLS 408
+A+P P V+W KD + SA + TR S L + V +AG+YT+
Sbjct: 340 FEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAF 399
Query: 409 IKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKW 466
+ + V L+ L +NV ++ E + S +P Q + C G+PQP I W
Sbjct: 400 HEDAEV--QLSFQLQINVPVRVLELSES-------HPDSGEQTVRCRGRGMPQPNIIW 448
Score = 38.1 bits (87), Expect = 0.029
Identities = 32/134 (23%), Positives = 51/134 (38%), Gaps = 4/134 (2%)
Query: 569 EGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSL 628
+GE++ L C V + W R + R + + + I L I + L
Sbjct: 227 QGENITLMCIVIGNEVVNFEWTYPRKESGRLVE---PVTDFLLDMPYHIRSILHIPSAEL 283
Query: 629 QDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVA-ISSSTTLDCHANGV 687
+DSGTY C + + IT+ + LL + A + S TL
Sbjct: 284 EDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAY 343
Query: 688 PEPQITWFKNNHKI 701
P P + WFK+N +
Sbjct: 344 PPPTVLWFKDNRTL 357
Score = 35.4 bits (80), Expect = 0.19
Identities = 45/200 (22%), Positives = 84/200 (42%), Gaps = 10/200 (5%)
Query: 499 GNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNG 558
G +E +T + + + + A+ SG Y C + V + IT V +G
Sbjct: 255 GRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESG 314
Query: 559 FHVNLEKMPT-EGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSI 617
+ L ++ T + +L S T+ +L +NRT+ S + + T+ S
Sbjct: 315 YVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSE 374
Query: 618 TL---NLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAI 674
T LT++ V + ++G Y RA + ++ + +I + P + LS+ +
Sbjct: 375 TRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINV-----PVRVLELSE-SHPD 428
Query: 675 SSSTTLDCHANGVPEPQITW 694
S T+ C G+P+P I W
Sbjct: 429 SGEQTVRCRGRGMPQPNIIW 448
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 102 bits (254), Expect = 1e-21
Identities = 150/631 (23%), Positives = 237/631 (37%), Gaps = 87/631 (13%)
Query: 92 LTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEG 151
L ++ A+ + YSC V + KKE +YI RP + P I +T G
Sbjct: 2254 LQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYI------RPTITNSGSHPTEIIVTRG 2307
Query: 152 RELVIPCRVTS-PNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEAT 210
+ + + C V P TVT K + G I+ D + N + G C A
Sbjct: 2308 KSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEIL-DEGHILQLKNIHVSDTGRYVCVAV 2366
Query: 211 -VNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTAT-TPLNTRVQMTWSY 268
V G K L+ +II S P + ++ +++ L C A+ PL + +TW +
Sbjct: 2367 NVAGMTDKKYDLSVHAPPSIIGNHRS-PENISVVEKNSVSLTCEASGIPLPS---ITW-F 2421
Query: 269 PDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHI 328
D S RI + + + +D G YTC VR+ + + +
Sbjct: 2422 KDGWPVSLSNSVRILSGGRMLRLMQTTM-------EDAGQYTCVVRNAAGEERKIFGLSV 2474
Query: 329 YDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARY-LTRG 387
I ++ + V V K+S L+ +V P PE+ W KDG P E A + ++ G
Sbjct: 2475 LVPPHIVGENTLEDV--KVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGG 2532
Query: 388 YSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLG 447
L I +V G YT L S + K+ + +L V V P I P+ L
Sbjct: 2533 RFLQITNVQVPHTGRYTCLASSPAGH--KSRSFSLNVFVSPTIAGVGSDGNPEDVTVILN 2590
Query: 448 SRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQ 507
S L C AY P TI WF G +ES +
Sbjct: 2591 SPTSLVCEAYSYPPATITWF-----------------------------KDGTPLES-NR 2620
Query: 508 RMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRN--ISFYITDVPN-------G 558
+ I+ G + ++ A +G Y C+A+N+ G + ++ + YI + N G
Sbjct: 2621 NIRILPGGRTL--QILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPG 2678
Query: 559 FHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSIT 618
K+ L L C ++W H +I+ H+
Sbjct: 2679 LSPKEVKIKV-NNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIA------ANGHT-- 2729
Query: 619 LNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQ-----EAPYLL---RNLSDH 670
L I + D+G Y C A N+ +E+ I + E +L RN
Sbjct: 2730 --LQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAK 2787
Query: 671 TVAISSSTTLDCHANGVPEPQITWFKNNHKI 701
V I++ +L C N P P +TW+K+ H +
Sbjct: 2788 DVIINNPISLYCETNAAPPPTLTWYKDGHPL 2818
Score = 97.1 bits (240), Expect = 5e-20
Identities = 105/411 (25%), Positives = 168/411 (40%), Gaps = 62/411 (15%)
Query: 295 VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYR 354
+L + Q D G YTC + K + + +Y I + + VL + A
Sbjct: 2067 ILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQA----VE 2122
Query: 355 LSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLI-IKDVTEEDAGNYTILLSIKQSN 413
L + A P P + WLKDG P +K ++ S++ I+D +D G YT +
Sbjct: 2123 LLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGK 2182
Query: 414 VFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNH 473
KN + V P I S G+ L C + GIP P + W
Sbjct: 2183 TEKNYNVNIWV--PPNI---GGSDELTQLTVIEGNLISLLCESSGIPPPNLIW------- 2230
Query: 474 NHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIY 533
+ S +L +MG R+ I+ G ++ + +A+ + +Y
Sbjct: 2231 -----------KKKGSPVLT--DSMG--------RVRILSGGRQLQ--ISIAEKSDAALY 2267
Query: 534 ICIASNKVGTVGR--NISFYI--TDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTW 589
C+ASN GT + N+ YI T +G H E + T G+ + L C V VTW
Sbjct: 2268 SCVASNVAGTAKKEYNLQVYIRPTITNSGSHPT-EIIVTRGKSISLECEVQGIPPPTVTW 2326
Query: 590 ILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQ 649
+ + H I + + I E I L + N+ + D+G Y C A NV +
Sbjct: 2327 M-------KDGHPLIKAKGVEILDEGHI---LQLKNIHVSDTGRYVCVAVNVAG----MT 2372
Query: 650 KKEITIRDQEAPYLL---RNLSDHTVAISSSTTLDCHANGVPEPQITWFKN 697
K+ + P ++ R+ + +V +S +L C A+G+P P ITWFK+
Sbjct: 2373 DKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKD 2423
Score = 95.5 bits (236), Expect = 2e-19
Identities = 140/630 (22%), Positives = 234/630 (37%), Gaps = 90/630 (14%)
Query: 92 LTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEG 151
L + A+ + TG Y C+ + V K +Y+ S G E+I T
Sbjct: 3115 LHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPE--------REVIVETIS 3166
Query: 152 RELVIPCRVTS-PNITVTLKKFPLDTLIPDGKRI-IWDSRKGFIISNATYKEIGLLTCEA 209
+ + C T P T+ K D + I I+ + + + G TC A
Sbjct: 3167 NPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIA 3226
Query: 210 T-VNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTAT---TPLNTRVQMT 265
+ + G K +L+ + ++ +I P V +L G + L C A TPL +
Sbjct: 3227 SNMEGKAQKYYFLSIQVPPSVAGAEI--PSDVSVLLGENVELVCNANGIPTPL-----IQ 3279
Query: 266 WSYPDEKNKRASVRR-RIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNT 324
W + R R+ + S NI Y LT D G YTC + +
Sbjct: 3280 WLKDGKPIASGETERIRVSANGSTLNI-YGALT------SDTGKYTCVATNPAGEEDRIF 3332
Query: 325 SVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKS-ARY 383
++++Y I + + L T+ S + + P P++ WLK+GLP S R
Sbjct: 3333 NLNVYVTPTIRGNKDEAEKLMTLVDT-SINIECRATGTPPPQINWLKNGLPLPLSSHIRL 3391
Query: 384 LTRGYSLIIKDVTEEDAGNYTILLSIKQS--NVFKNLTATLIVNVKPQIYEKAVSSFPDP 441
L G + I D YT + S + N NL N+ + + ++
Sbjct: 3392 LAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLK-- 3449
Query: 442 ALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNR 501
GS + C G P P++ W + + LDA +
Sbjct: 3450 -----GSSTSMACITDGTPAPSMAWL-----------------RDGQPLGLDAHLTVST- 3486
Query: 502 IESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVP--NGF 559
+ M L+ A++ SG Y CIASN+ G V ++ + + P NG
Sbjct: 3487 --------------HGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGS 3532
Query: 560 HVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITL 619
+ E L+L+C + +TW+ + R + + Q + +
Sbjct: 3533 EEHEEISVIVNNPLELTCIASGIPAPKMTWMK----DGRPLPQTDQVQTLGGGEV----- 3583
Query: 620 NLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLS--DHTVAISSS 677
L I ++D+G Y C A + ++ KE +R P + D TV +
Sbjct: 3584 -LRISTAQVEDTGRYTCLASSPAGDDD----KEYLVRVHVPPNIAGTDEPRDITVLRNRQ 3638
Query: 678 TTLDCHANGVPEPQITWFKNNHKIQQEPEL 707
TL+C ++ VP P ITW +N ++Q P +
Sbjct: 3639 VTLECKSDAVPPPVITWLRNGERLQATPRV 3668
Score = 95.1 bits (235), Expect = 2e-19
Identities = 140/620 (22%), Positives = 230/620 (37%), Gaps = 113/620 (18%)
Query: 98 QANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIP 157
Q NH G Y+C ++ + ++ + P ++ P +H+ +++P
Sbjct: 3958 QLNHAGRYTC------VARNAAGSAHRHVTLHVHEPPVIQPQ---PSELHVILNNPILLP 4008
Query: 158 CRVT-SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEA-----TV 211
C T +P+ +T +K ++ + S G IS A ++ G C A T
Sbjct: 4009 CEATGTPSPFITWQKEGINVNTSGRNHAVLPSG-GLQISRAVREDAGTYMCVAQNPAGTA 4067
Query: 212 NGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDE 271
G + + + + + I+ +P+ TL P + +TW + D
Sbjct: 4068 LGKIKLNVQVPPVISPHLKEYVIAVDKPI------TLSCEADGLPPPD----ITW-HKDG 4116
Query: 272 KNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIY 329
+ S+R+R+ S S L I +Q D G YTC + G S S +VH+
Sbjct: 4117 RAIVESIRQRVLSSGS--------LQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVP 4168
Query: 330 DK-----AFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYL 384
+ TV Q +L VA P+P + W KD + +Y
Sbjct: 4169 PRIRSTEGHYTVNENSQAILPCVAD-----------GIPTPAINWKKDNVLLANLLGKYT 4217
Query: 385 TRGYS-LIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPAL 443
Y LI+++V ED+G YT + + T +L V+V P E P
Sbjct: 4218 AEPYGELILENVVLEDSGFYTCVANNAAGE--DTHTVSLTVHVLPTFTE-----LPGDVS 4270
Query: 444 YPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIE 503
G + L+C A GIP P + W + N+N A D + + E
Sbjct: 4271 LNKGEQLRLSCKATGIPLPKLTWTF---NNNIIPAHFDSVNGHSE--------------- 4312
Query: 504 SITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNL 563
+IE +K SG Y+C A N VG V + I F P F +
Sbjct: 4313 ------LVIERVSK----------EDSGTYVCTAENSVGFV-KAIGFVYVKEPPVFKGDY 4355
Query: 564 EKMPTE--GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNL 621
E G + L+C V + W N + + IS + + +L
Sbjct: 4356 PSNWIEPLGGNAILNCEVKGDPTPTIQW------NRKGVDIEISHRIRQLGNG-----SL 4404
Query: 622 TIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLD 681
I +D+G Y C V T E + ++ +++ Q P + + + L+
Sbjct: 4405 AIYGTVNEDAGDYTC----VATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILN 4460
Query: 682 CHANGVPEPQITWFKNNHKI 701
C A G P+P ITW + H I
Sbjct: 4461 CQATGEPQPTITWSRQGHSI 4480
Score = 91.3 bits (225), Expect = 3e-18
Identities = 134/620 (21%), Positives = 221/620 (35%), Gaps = 87/620 (14%)
Query: 92 LTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEG 151
L L A+ N G Y C + K+ + IYI S G S + + E
Sbjct: 1510 LHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLEC 1569
Query: 152 RELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFI-------ISNATYKEIGL 204
+P P T DG+ I+ S+ +I I A +
Sbjct: 1570 ETRGLP--------------MPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSAT 1615
Query: 205 LTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQM 264
TC + ++ +I+ ++TP +++ H+L L C A N +
Sbjct: 1616 YTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAG--NPSPIL 1673
Query: 265 TWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNT 324
TW D +A+ RI+ L I Q D+G Y C S K +
Sbjct: 1674 TW-LKDGVPVKANDNIRIEAGGKK-------LEIMSAQEIDRGQYICVATSVAGEKEIKY 1725
Query: 325 SVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSA-RY 383
V + I + V L V P P ++WLKDG E+ +
Sbjct: 1726 EVDVLVPPAIEGGDETSYFIVMV--NNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKI 1783
Query: 384 LTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPAL 443
L G L+I + G Y + + + K T V+V P I +S
Sbjct: 1784 LLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVT--VHVPPTIKSSGLSERVVVKY 1841
Query: 444 YPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIE 503
P+ L C A GIP P+I W ++ + A N+ +I+
Sbjct: 1842 KPVA----LQCIANGIPNPSITWL------------------KDDQPVNTAQGNL--KIQ 1877
Query: 504 SITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVN- 562
S + + I A TL+ +G Y C+A+N G ++I ++ + P+
Sbjct: 1878 SSGRVLQI-------AKTLL----EDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGK 1926
Query: 563 -LEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNL 621
L + ++L C +TW +NR + S S M I +
Sbjct: 1927 MLNETVLVSNPVQLECKAAGNPVPVITWY----KDNRLLSGSTS---MTFLNRGQI---I 1976
Query: 622 TIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLD 681
I + + D+G Y C A N E+ ++ + AP + + + V +++ L+
Sbjct: 1977 DIESAQISDAGIYKCVAINSAGATELFYSLQVHV----APSISGSNNMVAVVVNNPVRLE 2032
Query: 682 CHANGVPEPQITWFKNNHKI 701
C A G+P P +TW K+ +
Sbjct: 2033 CEARGIPAPSLTWLKDGSPV 2052
Score = 91.3 bits (225), Expect = 3e-18
Identities = 136/631 (21%), Positives = 239/631 (37%), Gaps = 116/631 (18%)
Query: 92 LTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEG 151
L ++TAQ TG Y+C + KE +++ + G ++ P I +
Sbjct: 3584 LRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAG-------TDEPRDITVLRN 3636
Query: 152 RELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATV 211
R++ + C+ + P+ T + +G+R+ R I+S Y +I T
Sbjct: 3637 RQVTLECKSDAVPP-------PVITWLRNGERLQATPRVR-ILSGGRYLQINNADLGDTA 3688
Query: 212 NGHLYKTNYLTHRQTNTIIDVQIST-----PRPVKLLRGHTLVLNCTATTPLNTRVQMTW 266
N +N I+ V + P+ + +L + VL C A R+ TW
Sbjct: 3689 NYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRI--TW 3746
Query: 267 SYPDEKNKRASVRRRIDQSNSHANIFYSVLT-----IDKMQNKDKGLYTCRVRS--GPSF 319
K +V + +HA YS+L I D G Y C + G
Sbjct: 3747 ------RKDGAVL-----AGNHAR--YSILENGFLHIQSAHVTDTGRYLCMATNAAGTDR 3793
Query: 320 KSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG----LP 375
+ ++ VH+ I V+ V L+ + P P + W K+G +
Sbjct: 3794 RRIDLQVHVPPS--IAPGPTNMTVIVNV----QTTLACEATGIPKPSINWRKNGHLLNVD 3847
Query: 376 ATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV 435
+ S R L+ G SL+I + +D Y ++ + T L V V P I ++
Sbjct: 3848 QNQNSYRLLSSG-SLVIISPSVDDTATYECTVTNGAGD--DKRTVDLTVQVPPSIADE-- 3902
Query: 436 SSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDAD 495
P L + ++TCTA G+P P+I W + N + D
Sbjct: 3903 ---PTDFLVTKHAPAVITCTASGVPFPSIHW-----------------TKNGIRLLPRGD 3942
Query: 496 SNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDV 555
G RI S A ++ +G Y C+A N G+ R+++ ++ +
Sbjct: 3943 ---GYRILS------------SGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEP 3987
Query: 556 PNGFHVNLEKMPTE-----GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMA 610
P ++ P+E + L C +TW ++ + S + A
Sbjct: 3988 P-----VIQPQPSELHVILNNPILLPCEATGTPSPFITW------QKEGINVNTSGRNHA 4036
Query: 611 ITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDH 670
+ + ++ + +D+GTY C A+N G + +I + Q P + +L ++
Sbjct: 4037 VLPSGGLQISRAVR----EDAGTYMCVAQNP-AGTAL---GKIKLNVQVPPVISPHLKEY 4088
Query: 671 TVAISSSTTLDCHANGVPEPQITWFKNNHKI 701
+A+ TL C A+G+P P ITW K+ I
Sbjct: 4089 VIAVDKPITLSCEADGLPPPDITWHKDGRAI 4119
Score = 90.1 bits (222), Expect = 7e-18
Identities = 101/424 (23%), Positives = 156/424 (36%), Gaps = 70/424 (16%)
Query: 294 SVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSY 353
SVL I+ Q +D G YTC + N +V+I+ I Q+ TV
Sbjct: 2157 SVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQL--TVIEGNLI 2214
Query: 354 RLSMKVKAFPSPEVVWLKDGLPATEKS---ARYLTRGYSLIIKDVTEEDAGNYTILLSIK 410
L + P P ++W K G P S R L+ G L I + DA Y+ + S
Sbjct: 2215 SLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNV 2274
Query: 411 QSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHP 470
K L V ++P I S P + G L C GIP PT+ W
Sbjct: 2275 AGTAKKEYN--LQVYIRPTITNSG--SHPTEIIVTRGKSISLECEVQGIPPPTVTWM--- 2327
Query: 471 CNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS 530
H + +E IL + + V+D+
Sbjct: 2328 -KDGHPLIKAKGVEILDEGHILQLKN-------------------------IHVSDT--- 2358
Query: 531 GIYICIASNKVGTVGRNISFYITDVPN--GFHVNLEKMPT-EGEDLKLSCTVNKFLYRDV 587
G Y+C+A N G + + P+ G H + E + E + L+C + +
Sbjct: 2359 GRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSI 2418
Query: 588 TWILLRTVNNRTMHYSISKQKMAITKEHSITL-----NLTIMNVSLQDSGTYACRARNVY 642
TW K ++ +S+ + L +M +++D+G Y C RN
Sbjct: 2419 TWF---------------KDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNA- 2462
Query: 643 TGEEILQKKEITIRDQEAPYLL--RNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHK 700
GEE +K + P+++ L D V S TL C G P P+ITW K+
Sbjct: 2463 AGEE---RKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQP 2519
Query: 701 IQQE 704
+Q++
Sbjct: 2520 LQED 2523
Score = 90.1 bits (222), Expect = 7e-18
Identities = 142/672 (21%), Positives = 259/672 (38%), Gaps = 92/672 (13%)
Query: 66 MVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIY 125
+ S E+ER+ ++ + STL + A + TG Y+C +A + +++ +
Sbjct: 3287 IASGETERIRVSANG---------STLNIYGALTSDTGKYTC--VATNPAGEEDRIFNLN 3335
Query: 126 IFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRI 184
++++ T R + ++ ++ + + I CR T +P + K L + R+
Sbjct: 3336 VYVTPTIRGNKDEAEKLMTLVDTS----INIECRATGTPPPQINWLKNGLPLPLSSHIRL 3391
Query: 185 IWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLR 244
+ + I+ A ++ + TC A+ + +Y +D + T + +L+
Sbjct: 3392 LAAGQVIRIV-RAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEE-ITVLK 3449
Query: 245 GHTLVLNC-TATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQN 303
G + + C T TP + + P + +V ++H VL + K +
Sbjct: 3450 GSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTV-------STHG----MVLQLLKAET 3498
Query: 304 KDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFP 363
+D G YTC + S + + + + I +++ +V L+ P
Sbjct: 3499 EDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEI--SVIVNNPLELTCIASGIP 3556
Query: 364 SPEVVWLKDG--LPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTAT 421
+P++ W+KDG LP T++ + L G L I ED G YT L S + K
Sbjct: 3557 APKMTWMKDGRPLPQTDQ-VQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVR 3615
Query: 422 LIVNVKPQIYEKAVSSFPDPA-LYPLGSRQI-LTCTAYGIPQPTIKWFWHPCNHNHSEAR 479
V+V P I + +P + L +RQ+ L C + +P P I W
Sbjct: 3616 --VHVPPNI-----AGTDEPRDITVLRNRQVTLECKSDAVPPPVITWL------------ 3656
Query: 480 CDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASN 539
G R+++ T R+ I+ G + + AD + Y C+ASN
Sbjct: 3657 -----------------RNGERLQA-TPRVRILSGGRYL--QINNADLGDTANYTCVASN 3696
Query: 540 KVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTV-NNR 598
G R + PN + + L C +TW V
Sbjct: 3697 IAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGN 3756
Query: 599 TMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQ 658
YSI + L I + + D+G Y C A N + ++ I ++
Sbjct: 3757 HARYSILENGF-----------LHIQSAHVTDTGRYLCMATNAAGTD----RRRIDLQVH 3801
Query: 659 EAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPELYTSTSPSSSSS 718
P + ++ TV ++ TTL C A G+P+P I W KN H + + + SS S
Sbjct: 3802 VPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSL 3861
Query: 719 SPLSSSSSSSSS 730
+S S +++
Sbjct: 3862 VIISPSVDDTAT 3873
Score = 89.0 bits (219), Expect = 1e-17
Identities = 127/535 (23%), Positives = 201/535 (37%), Gaps = 89/535 (16%)
Query: 180 DGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRP 239
DG RI+ S I G TC A + H +I Q P
Sbjct: 3942 DGYRIL--SSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQ---PSE 3996
Query: 240 VKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTID 299
+ ++ + ++L C AT + + TW + N S R +HA + L I
Sbjct: 3997 LHVILNNPILLPCEATGTPSPFI--TWQ-KEGINVNTSGR-------NHAVLPSGGLQIS 4046
Query: 300 KMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSM 357
+ +D G Y C ++ G + + +V + + H K+ V +A + LS
Sbjct: 4047 RAVREDAGTYMCVAQNPAGTALGKIKLNVQVPP---VISPHLKEYV---IAVDKPITLSC 4100
Query: 358 KVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKN 417
+ P P++ W KDG E + + SL I V DAG+YT + + + +
Sbjct: 4101 EADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGS--SS 4158
Query: 418 LTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSE 477
+ L V+V P+I S S+ IL C A GIP P I W
Sbjct: 4159 TSTKLTVHVPPRI-----RSTEGHYTVNENSQAILPCVADGIPTPAINW----------- 4202
Query: 478 ARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIA 537
+++ +L +N+ + + I+E +V+ D SG Y C+A
Sbjct: 4203 --------KKDNVLL---ANLLGKYTAEPYGELILE-------NVVLED---SGFYTCVA 4241
Query: 538 SNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNN 597
+N G +S + +P + + +GE L+LSC +TW T NN
Sbjct: 4242 NNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTW----TFNN 4297
Query: 598 RTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN---VYTGEEILQKKEIT 654
+I HS L I VS +DSGTY C A N + KE
Sbjct: 4298 -----NIIPAHFDSVNGHS---ELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPP 4349
Query: 655 IRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKN------NHKIQQ 703
+ + P S+ + + L+C G P P I W + +H+I+Q
Sbjct: 4350 VFKGDYP------SNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQ 4398
Score = 88.6 bits (218), Expect = 2e-17
Identities = 146/650 (22%), Positives = 239/650 (36%), Gaps = 120/650 (18%)
Query: 92 LTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSE-IPEIIHMTE 150
L + Q HTG Y+C LA + K ++ +F+S T + S+ PE + +
Sbjct: 2535 LQITNVQVPHTGRYTC--LASSPAGHKSRSFSLNVFVSPT---IAGVGSDGNPEDVTVIL 2589
Query: 151 GRELVIPCRVTS-PNITVTLKK--FPLDT-----LIPDGKRIIWDSRKGFIISNATYKEI 202
+ C S P T+T K PL++ ++P G+ + I NA
Sbjct: 2590 NSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQ--------ILNAQEDNA 2641
Query: 203 GLLTCEATVN-GHLYKTNYLTHRQTNTIIDVQIS---------TPRPVKLLRGHTLVLNC 252
G +C AT G + K H + I I+ +P+ VK+ +TL L C
Sbjct: 2642 GRYSCVATNEAGEMIK-----HYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLEC 2696
Query: 253 TATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYS--VLTIDKMQNKDKGLYT 310
A + ++W Y D + + S+ H NI + L I + Q D G YT
Sbjct: 2697 EAYAIPSA--SLSW-YKDGQPLK---------SDDHVNIAANGHTLQIKEAQISDTGRYT 2744
Query: 311 CRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLET--------VAGKRSYRLSMKVKAF 362
C + ++ V+I +L+T V L + A
Sbjct: 2745 CVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAA 2804
Query: 363 PSPEVVWLKDGLPATEK-SARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTAT 421
P P + W KDG P T L G L I EDAG YT + +
Sbjct: 2805 PPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVR 2864
Query: 422 LIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCD 481
++V P I + A S P+ + ++ C + G P P W
Sbjct: 2865 VLV---PPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSW--------------- 2906
Query: 482 FCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKV 541
+ +L+ D + I++ N + + G Y+C+A N
Sbjct: 2907 ---QKDGQPLLEDDHH------KFLSNGRILQILNTQITDI--------GRYVCVAENTA 2949
Query: 542 GTVGRNISFYITDVPNGFHVNLEKMPTEGED-LKLSCTVNKFLYRDVTWILLRTVNNRTM 600
G+ + + + P+ E + + + L+C V+ F D++W+
Sbjct: 2950 GSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLK--------- 3000
Query: 601 HYSISKQKMAITKEHSIT---LNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRD 657
++Q + + I L I+ + D G Y C A N GE KK+ ++
Sbjct: 3001 ----NEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAIN-QAGE---SKKKFSLTV 3052
Query: 658 QEAPYL----LRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQ 703
P + +LS V +S +L+C +N VP P ITW+KN I +
Sbjct: 3053 YVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITE 3102
Score = 87.4 bits (215), Expect = 4e-17
Identities = 133/568 (23%), Positives = 206/568 (36%), Gaps = 79/568 (13%)
Query: 143 PEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEI 202
P+ + + G+ + IPC + V T++ DG+ + + I AT +
Sbjct: 1177 PKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDA 1236
Query: 203 GLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKL---LRGHTLVLNCTAT-TPL 258
G+ TC AT +T H Q ++ + P + + C A TP
Sbjct: 1237 GIYTCVATNIAGTDETEITLHVQEPPTVE-DLEPPYNTTFQERVANQRIEFPCPAKGTPK 1295
Query: 259 NTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRV--RSG 316
T + W + N R R S ++L I + D G Y C +G
Sbjct: 1296 PT---IKWLH----NGRELTGREPGISILEDG---TLLVIASVTPYDNGEYICVAVNEAG 1345
Query: 317 PSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPA 376
+ + N VH+ +K ++Q +V + L +V+ PSP ++W KD +
Sbjct: 1346 TTERKYNLKVHVPP----VIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQV 1401
Query: 377 TEKSA-RYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV 435
TE S + + G L + T EDAG Y S K N+ T+ N+ + +
Sbjct: 1402 TESSTIQTVNNGKILKLFRATPEDAGRY----SCKAINIAG--TSQKYFNIDVLVPPTII 1455
Query: 436 -SSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDA 494
++FP+ L L C G P P I WF + + F+
Sbjct: 1456 GTNFPNEVSVVLNRDVALECQVKGTPFPDIHWF----------------KDGKPLFL--G 1497
Query: 495 DSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNI--SFYI 552
D N+ + R ++ KN A G Y C SN G ++I + YI
Sbjct: 1498 DPNV-----ELLDRGQVLHLKN--------ARRNDKGRYQCTVSNAAGKQAKDIKLTIYI 1544
Query: 553 TDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAIT 612
G +V + +KL C +TW S Q + I
Sbjct: 1545 PPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWY------KDGQPIMSSSQALYID 1598
Query: 613 KEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLS---D 669
K L I + DS TY C NV E K + P + NL+ +
Sbjct: 1599 KGQ----YLHIPRAQVSDSATYTCHVANVAGTAE----KSFHVDVYVPPMIEGNLATPLN 1650
Query: 670 HTVAISSSTTLDCHANGVPEPQITWFKN 697
V I+ S TL+C A G P P +TW K+
Sbjct: 1651 KQVVIAHSLTLECKAAGNPSPILTWLKD 1678
Score = 87.0 bits (214), Expect = 6e-17
Identities = 154/688 (22%), Positives = 254/688 (36%), Gaps = 116/688 (16%)
Query: 46 GQTLHLQCRGEAAHKWSLPEMVSKESERLSIT--KSACGRNGKQFCSTLTLNTAQANHTG 103
G + L C+ K S+ + SK+ E +S + K + G +G +L + + +G
Sbjct: 995 GIPVTLPCKASGNPKPSV--IWSKKGELISTSSAKFSAGADG-----SLYVVSPGGEESG 1047
Query: 104 FYSCKYLAVPTSKKKETESAIYIFISDTGRPFV-----EMYSEIPEIIHMTEGRELVIPC 158
Y C K++ + +Y+ RP V + + P I + G E+ +PC
Sbjct: 1048 EYVCTATNTAGYAKRKVQLTVYV------RPRVFGDQRGLSQDKPVEISVLAGEEVTLPC 1101
Query: 159 RVTS--PNITVTLKKF-------PLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEA 209
V S P I K+ P T +P G I ++R + G+ C A
Sbjct: 1102 EVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTS---------DSGMYLCVA 1152
Query: 210 T-VNGHLYKTNYLTHRQTNTIIDVQIST-PRPVKLLRGHTLVLNCTAT-TPLNTRVQMTW 266
T + G++ + L N + +I P+ +K+ G + + C A TPL +TW
Sbjct: 1153 TNIAGNVTQAVKL-----NVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPV---ITW 1204
Query: 267 SYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSV 326
S + +D + H + L+ID+ D G+YTC + ++
Sbjct: 1205 S-------KGGSTMLVDGEH-HVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITL 1256
Query: 327 HIYDKAFITVKHRKQQVL--ETVAGKRSYRLSMKVKAFPSPEVVWLKDG--LPATEKSAR 382
H+ + + E VA +R K P P + WL +G L E
Sbjct: 1257 HVQEPPTVEDLEPPYNTTFQERVANQR-IEFPCPAKGTPKPTIKWLHNGRELTGREPGIS 1315
Query: 383 YLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPA 442
L G L+I VT D G Y I +++ ++ + L V+V P I +K +
Sbjct: 1316 ILEDGTLLVIASVTPYDNGEY-ICVAVNEAGTTER-KYNLKVHVPPVIKDKEQVTNVSVL 1373
Query: 443 LYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRI 502
L L + L C G P P I W+ +N +
Sbjct: 1374 LNQLTN---LFCEVEGTPSPIIMWY----------------KDNVQ-------------- 1400
Query: 503 ESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGR--NISFYITDVPNGFH 560
+T+ I N L A +G Y C A N GT + NI + G +
Sbjct: 1401 --VTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTN 1458
Query: 561 VNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLN 620
E D+ L C V + D+ W + + + + + + +
Sbjct: 1459 FPNEVSVVLNRDVALECQVKGTPFPDIHWFK----DGKPLF--LGDPNVELLDRGQV--- 1509
Query: 621 LTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRN--LSDHTVAISSST 678
L + N D G Y C N G+ Q K+I + P + +D +V I+S
Sbjct: 1510 LHLKNARRNDKGRYQCTVSNA-AGK---QAKDIKLTIYIPPSIKGGNVTTDISVLINSLI 1565
Query: 679 TLDCHANGVPEPQITWFKNNHKIQQEPE 706
L+C G+P P ITW+K+ I +
Sbjct: 1566 KLECETRGLPMPAITWYKDGQPIMSSSQ 1593
Score = 86.3 bits (212), Expect = 9e-17
Identities = 103/473 (21%), Positives = 171/473 (36%), Gaps = 61/473 (12%)
Query: 234 ISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFY 293
I P V + G VL C + ++ +TW D + A R +N
Sbjct: 523 IQVPNNVTVTPGERAVLTCLIISAVD--YNLTWQRNDRDVRLAEPARIRTLANLS----- 575
Query: 294 SVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSY 353
L + ++ D G Y C V S + + + + + +TV + Q + G
Sbjct: 576 --LELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQ----SFTGGSEV 629
Query: 354 RLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSN 413
+ +P P++ W + + +T +L IK+ +DAG Y L S
Sbjct: 630 SIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGT 689
Query: 414 VFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNH 473
+N T I K + + + L LG ++ C GIP P +KWF
Sbjct: 690 DKQNSTLRYIEAPKLMVVQSEL-------LVALGDITVMECKTSGIPPPQVKWF-----K 737
Query: 474 NHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIY 533
E R +F++ I+ + + I E ++ A G Y
Sbjct: 738 GDLELR-------PSTFLI---------IDPLLGLLKIQETQDLDA-----------GDY 770
Query: 534 ICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLR 593
C+A N+ G I+ + P + G ++ L C V + + W L
Sbjct: 771 TCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLD 830
Query: 594 TVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEI 653
+ + +S+S T L I+N+ D GTY C A N + +I + +
Sbjct: 831 NMPIFSRPFSVSSISQLRTGA------LFILNLWASDKGTYICEAENQF--GKIQSETTV 882
Query: 654 TIRDQEAPYLLRNLSDHTVAISSSTTLDCH-ANGVPEPQITWFKNNHKIQQEP 705
T+ AP + + S V TL C G P P+ W KN+ + Q P
Sbjct: 883 TVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNP 935
Score = 86.3 bits (212), Expect = 9e-17
Identities = 147/636 (23%), Positives = 231/636 (36%), Gaps = 110/636 (17%)
Query: 84 NGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIP 143
NGK L L A G YSCK + + + +K F D P + + P
Sbjct: 1412 NGK----ILKLFRATPEDAGRYSCKAINIAGTSQK-------YFNIDVLVPPTIIGTNFP 1460
Query: 144 EIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRI--------IWDSRKGFIIS 195
+ + R++ + C+V FP DGK + + D + +
Sbjct: 1461 NEVSVVLNRDVALECQVKGT-------PFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLK 1513
Query: 196 NATYKEIGLLTCEAT-VNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNC-T 253
NA + G C + G K LT +I ++T + +L + L C T
Sbjct: 1514 NARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTD--ISVLINSLIKLECET 1571
Query: 254 ATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRV 313
P+ +TW + +S ID+ L I + Q D YTC V
Sbjct: 1572 RGLPMPA---ITWYKDGQPIMSSSQALYIDKGQ--------YLHIPRAQVSDSATYTCHV 1620
Query: 314 RS--GPSFKSVNTSVHIYD--KAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVW 369
+ G + KS + V++ + + KQ V+ S L K PSP + W
Sbjct: 1621 ANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIA-----HSLTLECKAAGNPSPILTW 1675
Query: 370 LKDGLPA-TEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKP 428
LKDG+P + R G L I E D G Y + + K + + V V P
Sbjct: 1676 LKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGE--KEIKYEVDVLVPP 1733
Query: 429 QIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEE 488
I +S+ + + + L C G P PTI W
Sbjct: 1734 AIEGGDETSY---FIVMVNNLLELDCHVTGSPPPTIMWL--------------------- 1769
Query: 489 SFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS--GIYICIASNKVGTVGR 546
G I+ ++ G+ LV+A +++S G+Y C+A+N G +
Sbjct: 1770 --------KDGQLIDERDGFKILLNGRK-----LVIAQAQVSNTGLYRCMAANTAGDHKK 1816
Query: 547 NISFYITDVPNGFHVNL-EKMPTEGEDLKLSCTVNKFLYRDVTWIL-LRTVNNRTMHYSI 604
+ P L E++ + + + L C N +TW+ + VN + I
Sbjct: 1817 EFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKI 1876
Query: 605 SKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYL- 663
L I L+D+G Y C A N GE ++ I + E P L
Sbjct: 1877 QSSGRV----------LQIAKTLLEDAGRYTCVATNA-AGE---TQQHIQLHVHEPPSLE 1922
Query: 664 -LRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNN 698
+ + TV +S+ L+C A G P P ITW+K+N
Sbjct: 1923 DAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDN 1958
Score = 83.2 bits (204), Expect = 8e-16
Identities = 142/640 (22%), Positives = 244/640 (38%), Gaps = 100/640 (15%)
Query: 84 NGKQFCS---TLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYS 140
NG Q S L L +AQ + TG Y+C + K+++ + +Y+ P M
Sbjct: 2057 NGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYV-------PPNIMGE 2109
Query: 141 EIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYK 200
E + +++ EL+ P LK L+ I ++R I +A +
Sbjct: 2110 EQNVSVLISQAVELLCQSDAIPPPTLTWLKDG--HPLLKKPGLSISENRSVLKIEDAQVQ 2167
Query: 201 EIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTP---RPVKLLRGHTLVLNCTAT-- 255
+ G TCEAT + NY N + I + ++ G+ + L C ++
Sbjct: 2168 DTGRYTCEATNVAGKTEKNY----NVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGI 2223
Query: 256 TPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYS--VLTIDKMQNKDKGLYTCRV 313
P N + W K K + V + S I L I + D LY+C
Sbjct: 2224 PPPN----LIW-----KKKGSPV---LTDSMGRVRILSGGRQLQISIAEKSDAALYSCVA 2271
Query: 314 R--SGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLK 371
+G + K N V+I + H + + V +S L +V+ P P V W+K
Sbjct: 2272 SNVAGTAKKEYNLQVYIRPTITNSGSHPTEII---VTRGKSISLECEVQGIPPPTVTWMK 2328
Query: 372 DGLPATE-KSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQI 430
DG P + K L G+ L +K++ D G Y + +++ + + + L V+ P I
Sbjct: 2329 DGHPLIKAKGVEILDEGHILQLKNIHVSDTGRY-VCVAVNVAGM-TDKKYDLSVHAPPSI 2386
Query: 431 YEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESF 490
S P+ + LTC A GIP P+I WF ++ +
Sbjct: 2387 IGNHRS--PENISVVEKNSVSLTCEASGIPLPSITWF-------------------KDGW 2425
Query: 491 ILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISF 550
+ S++ + I+ G + L+ +G Y C+ N G +
Sbjct: 2426 PV-----------SLSNSVRILSGGRML--RLMQTTMEDAGQYTCVVRNAAGEERKIFGL 2472
Query: 551 YITDVPN--GFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWIL-LRTVNNRTMHYSISKQ 607
+ P+ G + + E + + L+C V ++TW + + H+ IS
Sbjct: 2473 SVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGG 2532
Query: 608 KMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLL--- 664
+ L I NV + +G Y C A + G + + ++ +P +
Sbjct: 2533 RF-----------LQITNVQVPHTGRYTCLASSP-AGH---KSRSFSLNVFVSPTIAGVG 2577
Query: 665 --RNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQ 702
N D TV ++S T+L C A P ITWFK+ ++
Sbjct: 2578 SDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLE 2617
Score = 81.6 bits (200), Expect = 2e-15
Identities = 138/688 (20%), Positives = 260/688 (37%), Gaps = 103/688 (14%)
Query: 43 MQAGQTLHLQCR----GEAAHKWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQ 98
M+ G + L C E KW + + S S++ + R G F L
Sbjct: 804 MEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLW----- 858
Query: 99 ANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPC 158
A+ G Y C+ ++ + +S + ++ P + + P + ++ EG++L +PC
Sbjct: 859 ASDKGTYICE----AENQFGKIQSETTVTVTGLVAPLIGIS---PSVANVIEGQQLTLPC 911
Query: 159 RVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEAT-VNGHLYK 217
+ + N + ++ I S I ++ G TC A+ V G K
Sbjct: 912 TLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNK 971
Query: 218 TNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRAS 277
T + TI Q + + + G + L C A+ N + + WS E +S
Sbjct: 972 TTSVVVHVLPTIQHGQ----QILSTIEGIPVTLPCKASG--NPKPSVIWSKKGELISTSS 1025
Query: 278 VRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRV--RSGPSFKSVNTSVHIYDKAFIT 335
+ S L + ++ G Y C +G + + V +V++ + F
Sbjct: 1026 AKFSAGADGS--------LYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGD 1077
Query: 336 VKHRKQQ--VLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSAR--YLTRGYSLI 391
+ Q V +V L +VK+ P P + W K+ + S R +L G S+
Sbjct: 1078 QRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSG-SMK 1136
Query: 392 IKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQI 451
I + D+G Y + +N+ N+T + +NV + P +G R
Sbjct: 1137 ITETRTSDSGMYLCV----ATNIAGNVTQAVKLNVH---VPPKIQRGPKHLKVQVGQRVD 1189
Query: 452 LTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAI 511
+ C A G P P I W S + ++D + ++ N ++
Sbjct: 1190 IPCNAQGTPLPVITW-----------------SKGGSTMLVDGEHHVSNPDGTL------ 1226
Query: 512 IEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPN------GFHVNLEK 565
++ A +GIY C+A+N GT I+ ++ + P ++ ++
Sbjct: 1227 ---------SIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQE 1277
Query: 566 MPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMN 625
+ ++ C + W+ N R ++ ++ I+ TL L I +
Sbjct: 1278 R-VANQRIEFPCPAKGTPKPTIKWL----HNGR----ELTGREPGISILEDGTL-LVIAS 1327
Query: 626 VSLQDSGTYACRARNVYTGEEILQKKEI----TIRDQEAPYLLRNLSDHTVAISSSTTLD 681
V+ D+G Y C A N E ++ I+D+E +++ +V ++ T L
Sbjct: 1328 VTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKE------QVTNVSVLLNQLTNLF 1381
Query: 682 CHANGVPEPQITWFKNNHKIQQEPELYT 709
C G P P I W+K+N ++ + + T
Sbjct: 1382 CEVEGTPSPIIMWYKDNVQVTESSTIQT 1409
Score = 79.3 bits (194), Expect = 1e-14
Identities = 102/417 (24%), Positives = 158/417 (37%), Gaps = 72/417 (17%)
Query: 296 LTIDKMQNKDKGLYTCRV--RSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSY 353
L I + + D G YTC ++G S K + +V++ ++K + L V +
Sbjct: 3020 LQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPP----SIKDHDSESLSVVNVREGT 3075
Query: 354 RLSMKVK--AFPSPEVVWLKDGLPATEKS-ARYLTRGYSLIIKDVTEEDAGNYTILLSIK 410
+S++ + A P P + W K+G TE + L G L IK D G Y
Sbjct: 3076 SVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINV 3135
Query: 411 QSNVFKNLTATLIV--NVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFW 468
KN + V +++ E V + +P LTC A GIP PTI W
Sbjct: 3136 AGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVT--------LTCDATGIPPPTIAWLK 3187
Query: 469 HPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSR 528
NH E N +S + I+ G +K+ + +
Sbjct: 3188 ---NHKRIE--------NSDSL-----------------EVRILSGGSKLQ--IARSQHS 3217
Query: 529 ISGIYICIASNKVGTVGRNISFYITDVPN--GFHVNLEKMPTEGEDLKLSCTVNKFLYRD 586
SG Y CIASN G + I P+ G + + GE+++L C N
Sbjct: 3218 DSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPL 3277
Query: 587 VTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEE 646
+ W+ + S +++ ++ S L I D+G Y C A N E+
Sbjct: 3278 IQWL-----KDGKPIASGETERIRVSANGS---TLNIYGALTSDTGKYTCVATNPAGEED 3329
Query: 647 ILQKKEI----TIRDQ--EAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKN 697
+ + TIR EA L+ + +S ++C A G P PQI W KN
Sbjct: 3330 RIFNLNVYVTPTIRGNKDEAEKLM-------TLVDTSINIECRATGTPPPQINWLKN 3379
Score = 79.3 bits (194), Expect = 1e-14
Identities = 111/449 (24%), Positives = 173/449 (38%), Gaps = 76/449 (16%)
Query: 91 TLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTE 150
+L + Q G Y+C V S T+ +++ P I TE
Sbjct: 4132 SLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHV----------------PPRIRSTE 4175
Query: 151 GR-------ELVIPC---RVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYK 200
G + ++PC + +P I L L+ GK + I+ N +
Sbjct: 4176 GHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLL--GKYTA-EPYGELILENVVLE 4232
Query: 201 EIGLLTCEAT-VNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTAT-TPL 258
+ G TC A G T LT T ++ P V L +G L L+C AT PL
Sbjct: 4233 DSGFYTCVANNAAGEDTHTVSLTVHVLPTFTEL----PGDVSLNKGEQLRLSCKATGIPL 4288
Query: 259 NTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPS 318
++TW++ + + D N H S L I+++ +D G Y C +
Sbjct: 4289 P---KLTWTFNNN-----IIPAHFDSVNGH-----SELVIERVSKEDSGTYVCTAENSVG 4335
Query: 319 FKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPAT- 377
F V++ + + + E + G L+ +VK P+P + W + G+
Sbjct: 4336 FVKAIGFVYVKEPPVFKGDYPSNWI-EPLGGNAI--LNCEVKGDPTPTIQWNRKGVDIEI 4392
Query: 378 EKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSS 437
R L G SL I EDAG+YT + + + V ++++ TL P I ++
Sbjct: 4393 SHRIRQLGNG-SLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTL---QSPPI----ITL 4444
Query: 438 FPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHS---EARCDFCSNNEESFILDA 494
P + G + IL C A G PQPTI W HS + R + SNN +I DA
Sbjct: 4445 EPVETVINAGGKIILNCQATGEPQPTITW----SRQGHSISWDDRVNVLSNN-SLYIADA 4499
Query: 495 DSNMGNRIESITQRMAIIEGKNKMASTLV 523
+ E + +N M S LV
Sbjct: 4500 QKEDTSEFECV--------ARNLMGSVLV 4520
Score = 78.6 bits (192), Expect = 2e-14
Identities = 100/444 (22%), Positives = 155/444 (34%), Gaps = 62/444 (13%)
Query: 295 VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYR 354
VL I + + +D G YTC + S+ V + I + TV +S
Sbjct: 2832 VLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSAL 2891
Query: 355 LSMKVKAFPSPEVVWLKDGLPATEKS-ARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSN 413
+ P+P W KDG P E ++L+ G L I + D G Y + +
Sbjct: 2892 IECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGS 2951
Query: 414 VFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNH 473
K L V+V P + + + + + LTC G P P + W
Sbjct: 2952 AKKYF--NLNVHVPPSV----IGPKSENLTVVVNNFISLTCEVSGFPPPDLSWL------ 2999
Query: 474 NHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS--G 531
NE+ L+ ++ I+ G TL + +++S G
Sbjct: 3000 -----------KNEQPIKLNTNT-------------LIVPG----GRTLQIIRAKVSDGG 3031
Query: 532 IYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPT----EGEDLKLSCTVNKFLYRDV 587
Y CIA N+ G + S + P+ + E + EG + L C N +
Sbjct: 3032 EYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVI 3091
Query: 588 TWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEI 647
TW + + H I L I + D+G Y CRA NV ++
Sbjct: 3092 TWYKNGRMITESTHVEILADGQM----------LHIKKAEVSDTGQYVCRAINVAGRDD- 3140
Query: 648 LQKKEITIRDQEAPYLLRNLSDHTV-AISSSTTLDCHANGVPEPQITWFKNNHKIQQEPE 706
K + P + + V IS+ TL C A G+P P I W KN+ +I+
Sbjct: 3141 ---KNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDS 3197
Query: 707 LYTSTSPSSSSSSPLSSSSSSSSS 730
L S S S S +
Sbjct: 3198 LEVRILSGGSKLQIARSQHSDSGN 3221
Score = 78.2 bits (191), Expect = 3e-14
Identities = 96/424 (22%), Positives = 166/424 (39%), Gaps = 61/424 (14%)
Query: 296 LTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGK-RS 352
L I + Q + GLY C + G K +VH+ T+K + E V K +
Sbjct: 1790 LVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPP----TIK--SSGLSERVVVKYKP 1843
Query: 353 YRLSMKVKAFPSPEVVWLKDGLPAT--EKSARYLTRGYSLIIKDVTEEDAGNYTILLSIK 410
L P+P + WLKD P + + + + G L I EDAG YT + +
Sbjct: 1844 VALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNA 1903
Query: 411 QSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHP 470
+++ L V+ P + E A + L + + L C A G P P I W+
Sbjct: 1904 AGETQQHIQ--LHVHEPPSL-EDAGKMLNETVL--VSNPVQLECKAAGNPVPVITWY--- 1955
Query: 471 CNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS 530
+++ +L ++M + R II+ ++ S +
Sbjct: 1956 ----------------KDNRLLSGSTSM-----TFLNRGQIIDIESAQISD--------A 1986
Query: 531 GIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWI 590
GIY C+A N G S + P+ N ++L C +TW+
Sbjct: 1987 GIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWL 2046
Query: 591 LLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQK 650
+ + S S ++ + L + + D+G Y C A N GE+ +
Sbjct: 2047 -----KDGSPVSSFSNGLQVLSGGRILALT----SAQISDTGRYTCVAVNA-AGEK---Q 2093
Query: 651 KEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPELYTS 710
++I +R P ++ + +V IS + L C ++ +P P +TW K+ H + ++P L S
Sbjct: 2094 RDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSIS 2153
Query: 711 TSPS 714
+ S
Sbjct: 2154 ENRS 2157
Score = 73.9 bits (180), Expect = 5e-13
Identities = 139/644 (21%), Positives = 234/644 (36%), Gaps = 106/644 (16%)
Query: 92 LTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEG 151
L L + TG Y C + V K+ + +++ S G PE I + E
Sbjct: 2348 LQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGN------HRSPENISVVEK 2401
Query: 152 RELVIPCRVTS---PNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCE 208
+ + C + P+IT +P+ + + RI+ R + T ++ G TC
Sbjct: 2402 NSVSLTCEASGIPLPSITWFKDGWPVS--LSNSVRILSGGRM-LRLMQTTMEDAGQYTCV 2458
Query: 209 A-TVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWS 267
G K L+ I+ +T VK+ ++ L C T N ++TW
Sbjct: 2459 VRNAAGEERKIFGLSVLVPPHIVGE--NTLEDVKVKEKQSVTLTCEVTG--NPVPEITWH 2514
Query: 268 YPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVH 327
+ + I L I +Q G YTC S KS + S++
Sbjct: 2515 KDGQPLQEDEAHHIISGGR--------FLQITNVQVPHTGRYTCLASSPAGHKSRSFSLN 2566
Query: 328 IYDKAFIT-VKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPA-TEKSARYLT 385
++ I V TV L + ++P + W KDG P + ++ R L
Sbjct: 2567 VFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILP 2626
Query: 386 RGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYP 445
G +L I + E++AG Y+ + + + + K+ + + P I K P L P
Sbjct: 2627 GGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYI---PPIINKG--DLWGPGLSP 2681
Query: 446 ------LGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMG 499
+ + L C AY IP ++ W+ ++ L +D ++
Sbjct: 2682 KEVKIKVNNTLTLECEAYAIPSASLSWY-------------------KDGQPLKSDDHVN 2722
Query: 500 NRIESITQRMAIIEGKNKMASTLVVADSRIS--GIYICIASNKVGTVGRNISFYITDVPN 557
TL + +++IS G Y C+ASN G + I VP
Sbjct: 2723 IAANG---------------HTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNI-QVPP 2766
Query: 558 GFHV-----NLEKMPTEGE--------DLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSI 604
F N+ GE + L C N +TW + H
Sbjct: 2767 SFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWY-------KDGHPLT 2819
Query: 605 SKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLL 664
S K+ I + L I ++D+G Y C A N GE+ LQ +R P +
Sbjct: 2820 SSDKVLILPGGRV---LQIPRAKVEDAGRYTCVAVNE-AGEDSLQ---YDVRVLVPPIIK 2872
Query: 665 RNLSDH----TVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE 704
SD TV ++ S ++C ++G P P+ +W K+ + ++
Sbjct: 2873 GANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLED 2916
Score = 73.6 bits (179), Expect = 6e-13
Identities = 98/421 (23%), Positives = 154/421 (36%), Gaps = 70/421 (16%)
Query: 295 VLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRS 352
+L + + +D G Y+C+ + G S K N V + T + V+ R
Sbjct: 1415 ILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLN----RD 1470
Query: 353 YRLSMKVKAFPSPEVVWLKDGLPAT--EKSARYLTRGYSLIIKDVTEEDAGNYTILLSIK 410
L +VK P P++ W KDG P + + L RG L +K+ D G Y +S
Sbjct: 1471 VALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNA 1530
Query: 411 QSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHP 470
K++ T+ + P I V++ D ++ + S L C G+P P I W+
Sbjct: 1531 AGKQAKDIKLTIYI--PPSIKGGNVTT--DISVL-INSLIKLECETRGLPMPAITWY--- 1582
Query: 471 CNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS 530
G I S +Q + I +G+ V+DS
Sbjct: 1583 --------------------------KDGQPIMSSSQALYIDKGQYLHIPRAQVSDS--- 1613
Query: 531 GIYICIASNKVGTVGRN--ISFYITDVPNG-FHVNLEKMPTEGEDLKLSCTVNKFLYRDV 587
Y C +N GT ++ + Y+ + G L K L L C +
Sbjct: 1614 ATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPIL 1673
Query: 588 TWILLRTVNNRTMHYSISKQKMAITKEHSITLN-----LTIMNVSLQDSGTYACRARNVY 642
TW+ K + + +I + L IM+ D G Y C A +V
Sbjct: 1674 TWL---------------KDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVA 1718
Query: 643 TGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQ 702
+EI K E+ + A S V +++ LDCH G P P I W K+ I
Sbjct: 1719 GEKEI--KYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLID 1776
Query: 703 Q 703
+
Sbjct: 1777 E 1777
Score = 71.6 bits (174), Expect = 2e-12
Identities = 128/621 (20%), Positives = 213/621 (34%), Gaps = 88/621 (14%)
Query: 103 GFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTS 162
GFY C ++ + + +T D P ++P + +T G V+ C + S
Sbjct: 495 GFYECIAVSSAGTGRAQT-------FFDVSEP--PPVIQVPNNVTVTPGERAVLTCLIIS 545
Query: 163 P-NITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYL 221
+ +T ++ D + + RI + + + + + G C + G +
Sbjct: 546 AVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVF 605
Query: 222 THRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRR 281
Q + V P+ G + + C+AT YP K
Sbjct: 606 LTVQEPPKVTVM---PKNQSFTGGSEVSIMCSAT-----------GYPKPKIAWTVNDMF 651
Query: 282 IDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQ 341
I S+ + L I KD G+Y C + N+++ + + V Q
Sbjct: 652 IVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVV---Q 708
Query: 342 QVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLI-IKDVTEEDA 400
L G + + K P P+V W K L + + L+ I++ + DA
Sbjct: 709 SELLVALGDITV-MECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDA 767
Query: 401 GNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIP 460
G+YT + + +T L V P ++ P +GS L C G P
Sbjct: 768 GDYTCVAINEAGRATGKIT--LDVGSPPVFIQE-----PADVSMEIGSNVTLPCYVQGYP 820
Query: 461 QPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMAS 520
+PTIKW R D F + + S + R + N AS
Sbjct: 821 EPTIKW-----------RRLDNMPIFSRPFSVSSISQL---------RTGALFILNLWAS 860
Query: 521 TLVVADSRISGIYICIASNKVGTVGRNISFYITDVPN---GFHVNLEKMPTEGEDLKLSC 577
G YIC A N+ G + + +T + G ++ + EG+ L L C
Sbjct: 861 D--------KGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANV-IEGQQLTLPC 911
Query: 578 TV---NKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTY 634
T+ N R R + N M + + + + S L I V LQD G Y
Sbjct: 912 TLLAGNPIPER-------RWIKNSAM--LLQNPYITVRSDGS----LHIERVQLQDGGEY 958
Query: 635 ACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITW 694
C A NV K ++ P + + TL C A+G P+P + W
Sbjct: 959 TCVASNVAG----TNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIW 1014
Query: 695 FKNNHKIQQEPELYTSTSPSS 715
K I +++ + S
Sbjct: 1015 SKKGELISTSSAKFSAGADGS 1035
Score = 67.4 bits (163), Expect = 5e-11
Identities = 150/690 (21%), Positives = 249/690 (36%), Gaps = 99/690 (14%)
Query: 32 PELSLKGTQHIMQAGQTLHLQCRG----EAAHKWSLPEMVSKESERLSITKSACGRNGKQ 87
P LS K + ++ TL L+C A+ W K + ++I +
Sbjct: 2677 PGLSPKEVK--IKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANG------- 2727
Query: 88 FCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIH 147
TL + AQ + TG Y+C +A + + E + + I + + + E+ + + +
Sbjct: 2728 --HTLQIKEAQISDTGRYTC--VASNIAGEDELDFDVNIQVPPSFQKLWEIGNML-DTGR 2782
Query: 148 MTEGRELVIPCRVT-------SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYK 200
E ++++I ++ +P T+T K L K +I + I A +
Sbjct: 2783 NGEAKDVIINNPISLYCETNAAPPPTLTWYKDG-HPLTSSDKVLILPGGRVLQIPRAKVE 2841
Query: 201 EIGLLTCEATVNGHLYKTNYLTHRQTNTIID-VQISTPRPVKLLRGHTLVLNCTATTPLN 259
+ G TC A Y II P V +L + ++ C ++
Sbjct: 2842 DAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSS---- 2897
Query: 260 TRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYS-VLTIDKMQNKDKGLYTCRVRS--G 316
P +N + + + + H + +L I Q D G Y C + G
Sbjct: 2898 -------GSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAG 2950
Query: 317 PSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPA 376
+ K N +VH+ +V K + L TV L+ +V FP P++ WLK+ P
Sbjct: 2951 SAKKYFNLNVHVPP----SVIGPKSENL-TVVVNNFISLTCEVSGFPPPDLSWLKNEQPI 3005
Query: 377 T-EKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV 435
+ + G +L I D G YT + +I Q+ K +L V V P I +
Sbjct: 3006 KLNTNTLIVPGGRTLQIIRAKVSDGGEYTCI-AINQAGESKK-KFSLTVYVPPSIKDHDS 3063
Query: 436 SSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDAD 495
S + G+ L C + +P P I W+ +
Sbjct: 3064 ESLSVVNVRE-GTSVSLECESNAVPPPVITWYKN-------------------------- 3096
Query: 496 SNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDV 555
G I T + +G+ V+D+ G Y+C A N G +N
Sbjct: 3097 ---GRMITESTHVEILADGQMLHIKKAEVSDT---GQYVCRAINVAGRDDKN-------- 3142
Query: 556 PNGFHVNLEKMPT----EGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAI 611
FH+N+ P+ E E + + + L D T I T+ H I
Sbjct: 3143 ---FHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLE 3199
Query: 612 TKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHT 671
+ S L I DSG Y C A N+ + I + A + SD +
Sbjct: 3200 VRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIP--SDVS 3257
Query: 672 VAISSSTTLDCHANGVPEPQITWFKNNHKI 701
V + + L C+ANG+P P I W K+ I
Sbjct: 3258 VLLGENVELVCNANGIPTPLIQWLKDGKPI 3287
Score = 64.7 bits (156), Expect = 3e-10
Identities = 155/766 (20%), Positives = 262/766 (34%), Gaps = 151/766 (19%)
Query: 2 VSYWDTGVLLCALLSCLLLTGSSSGSKL-----KDPELSLKGTQHIMQAGQTLHLQCRGE 56
V + D G C + S G SS + + + P++++ G + + C
Sbjct: 581 VKFNDAGEYHCMVSS----EGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSAT 636
Query: 57 AAHK----WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAV 112
K W++ +M S R +T TL + A G Y C LA
Sbjct: 637 GYPKPKIAWTVNDMFIVGSHRYRMTSDG----------TLFIKNAAPKDAGIYGC--LAS 684
Query: 113 PTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTE------GRELVIPCRVTSPNIT 166
++ + S + Y E P+++ + G V+ C+ TS
Sbjct: 685 NSAGTDKQNSTL-------------RYIEAPKLMVVQSELLVALGDITVMECK-TSGIPP 730
Query: 167 VTLKKFPLDTLIPDGKRIIWDSRKGFI-ISNATYKEIGLLTCEATVNGHLYKTNYLTHRQ 225
+K F D + +I D G + I + G TC A +N T +T
Sbjct: 731 PQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVA-INEAGRATGKITLDV 789
Query: 226 TNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQS 285
+ + +Q P V + G + L C YP+ K RR+D
Sbjct: 790 GSPPVFIQ--EPADVSMEIGSNVTLPCYVQ-----------GYPEPTIKW----RRLDNM 832
Query: 286 NSHANIFYSVLTIDKMQN----------KDKGLYTCRVRSGPSFKSVNTSVHIYDKAFIT 335
+ F SV +I +++ DKG Y C + F + + + +
Sbjct: 833 PIFSRPF-SVSSISQLRTGALFILNLWASDKGTYICEAEN--QFGKIQSETTVTVTGLVA 889
Query: 336 -VKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKD 394
+ V + G++ + P PE W+K+ + + SL I+
Sbjct: 890 PLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIER 949
Query: 395 VTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIY--EKAVSSFPDPALYPLGSRQIL 452
V +D G YT + S N T +++V+V P I ++ +S+ G L
Sbjct: 950 VQLQDGGEYTCVASNVAGT--NNKTTSVVVHVLPTIQHGQQILSTIE-------GIPVTL 1000
Query: 453 TCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAII 512
C A G P+P++ W + + S + F AD ++
Sbjct: 1001 PCKASGNPKPSVIW----------SKKGELISTSSAKFSAGADGSL-------------- 1036
Query: 513 EGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNL---EKMPTE 569
+V SG Y+C A+N G R + + P F + P E
Sbjct: 1037 --------YVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVE 1088
Query: 570 -----GEDLKLSCTVNKFLYRDVTWI----LLRTVNNRTMHYSISKQKMAITKEHSITLN 620
GE++ L C V +TW L+ + R H + M IT+ +
Sbjct: 1089 ISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPR--HTFLPSGSMKITETRT---- 1142
Query: 621 LTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTL 680
DSG Y C A N+ + Q ++ + P + R V + +
Sbjct: 1143 --------SDSGMYLCVATNI--AGNVTQAVKLNVH--VPPKIQRGPKHLKVQVGQRVDI 1190
Query: 681 DCHANGVPEPQITWFKNNHKIQQEPELYTSTSPSSSSSSPLSSSSS 726
C+A G P P ITW K + + E + S + S + S +
Sbjct: 1191 PCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDA 1236
Score = 63.5 bits (153), Expect = 7e-10
Identities = 92/426 (21%), Positives = 150/426 (35%), Gaps = 65/426 (15%)
Query: 280 RRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHR 339
R + + + + + + I Q G YTC R+ + ++H+++ I +
Sbjct: 3936 RLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPS 3995
Query: 340 KQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARY--LTRGYSLIIKDVTE 397
+ V+ L + PSP + W K+G+ + L G L I
Sbjct: 3996 ELHVILN----NPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSG-GLQISRAVR 4050
Query: 398 EDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILT--CT 455
EDAG Y V +N T + +K + V S P Y + + +T C
Sbjct: 4051 EDAGTYMC--------VAQNPAGTALGKIKLNVQVPPVIS-PHLKEYVIAVDKPITLSCE 4101
Query: 456 AYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGK 515
A G+P P I W H + R +ESI QR+ + G
Sbjct: 4102 ADGLPPPDITW--------HKDGRAI--------------------VESIRQRV-LSSGS 4132
Query: 516 NKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKL 575
++A +G Y C+A+N G+ + + P E L
Sbjct: 4133 LQIA----FVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAIL 4188
Query: 576 SCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYA 635
C + + W +N + + K E L + NV L+DSG Y
Sbjct: 4189 PCVADGIPTPAINW----KKDNVLLANLLGKYTAEPYGE------LILENVVLEDSGFYT 4238
Query: 636 CRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWF 695
C A N GE+ +++ P D ++ L C A G+P P++TW
Sbjct: 4239 CVANNA-AGED---THTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWT 4294
Query: 696 KNNHKI 701
NN+ I
Sbjct: 4295 FNNNII 4300
Score = 30.4 bits (67), Expect = 6.1
Identities = 22/90 (24%), Positives = 40/90 (44%), Gaps = 6/90 (6%)
Query: 614 EHSITLNLTIMNVSLQDSGTYACRA-RNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTV 672
+ S ++NL I V+L D G Y C A + TG + + E P +++ ++ TV
Sbjct: 477 KESASVNLDIAKVTLSDEGFYECIAVSSAGTG-----RAQTFFDVSEPPPVIQVPNNVTV 531
Query: 673 AISSSTTLDCHANGVPEPQITWFKNNHKIQ 702
L C + +TW +N+ ++
Sbjct: 532 TPGERAVLTCLIISAVDYNLTWQRNDRDVR 561
>gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 2 precursor [Homo sapiens]
Length = 972
Score = 93.2 bits (230), Expect = 8e-19
Identities = 122/500 (24%), Positives = 207/500 (41%), Gaps = 81/500 (16%)
Query: 5 WDTGVLLCALLSCLLL-TGSSSGS----KLKDPELSLKGTQHIMQAGQTLHLQCRGEAAH 59
WD LC LL L + TGSS S + P + + I++ G + L C
Sbjct: 8 WD---FLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFV 64
Query: 60 KWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKE 119
KW+ E++ + +E KQ + A+A +TG Y+C + K
Sbjct: 65 KWTF-EILDETNEN------------KQ--NEWITEKAEATNTGKYTC-------TNKHG 102
Query: 120 TESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIP 179
++IY+F+ D + F+ + ++ E + ++ C +T P +T K +P
Sbjct: 103 LSNSIYVFVRDPAKLFL-----VDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLP 157
Query: 180 DGKRIIWDSRKGFIISNA--TYKEIGLLTCEATVNGH--LYKTNYLTHRQTNTIIDVQIS 235
R I D + G +I + Y + L C G L + L R + V +S
Sbjct: 158 KDLRFIPDPKAGIMIKSVKRAYHRL-CLHCSVDQEGKSVLSEKFILKVRPAFKAVPV-VS 215
Query: 236 TPRPVKLLR-GHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFY- 293
+ LLR G + CT +++ V TW +N + ++ + + S H + Y
Sbjct: 216 VSKASYLLREGEEFTVTCTIKD-VSSSVYSTWK---RENSQTKLQEKYN-SWHHGDFNYE 270
Query: 294 --SVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKR 351
+ LTI + D G++ C + +V T++ + DK FI + + G+
Sbjct: 271 RQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGE- 329
Query: 352 SYRLSMKVKAFPSPE-VVWLKDGLPATEKSARYLTRGYSLIIKDVTE--------EDAGN 402
+ L ++ +AFP PE W+ T+K Y I+ V+E + G
Sbjct: 330 NVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGT 389
Query: 403 YTILLSIKQSNVFKNLTATLIVNVKPQI--YEKAVSSFPDPALYPLGSRQILTCTAYGIP 460
YT L+S S+V + + VN KP+I Y++ V+ +L C A G P
Sbjct: 390 YTFLVS--NSDVNAAIAFNVYVNTKPEILTYDRLVNG-------------MLQCVAAGFP 434
Query: 461 QPTIKWFWHPCNHNHSEARC 480
+PTI W++ P +E RC
Sbjct: 435 EPTIDWYFCP----GTEQRC 450
Score = 38.1 bits (87), Expect = 0.029
Identities = 45/185 (24%), Positives = 78/185 (42%), Gaps = 25/185 (13%)
Query: 520 STLVVADSRI--SGIYICIASNKVGTVGRNISFYITDVPNGF-----HVNLEKMPTEGED 572
+TL ++ +R+ SG+++C A+N G+ N++ + V GF +N +GE+
Sbjct: 273 ATLTISSARVNDSGVFMCYANNTFGSA--NVTTTLEVVDKGFINIFPMINTTVFVNDGEN 330
Query: 573 LKLSCTVNKFLYRD-VTWILL-RTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQD 630
+ L F + WI + RT ++ Y S+ + I + L+LT + + +
Sbjct: 331 VDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNI--RYVSELHLTRLKGT--E 386
Query: 631 SGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEP 690
GTY N I + + + Y D V + L C A G PEP
Sbjct: 387 GGTYTFLVSNSDVNAAIAFNVYVNTKPEILTY------DRLV----NGMLQCVAAGFPEP 436
Query: 691 QITWF 695
I W+
Sbjct: 437 TIDWY 441
>gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 1 precursor [Homo sapiens]
Length = 976
Score = 93.2 bits (230), Expect = 8e-19
Identities = 122/500 (24%), Positives = 207/500 (41%), Gaps = 81/500 (16%)
Query: 5 WDTGVLLCALLSCLLL-TGSSSGS----KLKDPELSLKGTQHIMQAGQTLHLQCRGEAAH 59
WD LC LL L + TGSS S + P + + I++ G + L C
Sbjct: 8 WD---FLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFV 64
Query: 60 KWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKE 119
KW+ E++ + +E KQ + A+A +TG Y+C + K
Sbjct: 65 KWTF-EILDETNEN------------KQ--NEWITEKAEATNTGKYTC-------TNKHG 102
Query: 120 TESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIP 179
++IY+F+ D + F+ + ++ E + ++ C +T P +T K +P
Sbjct: 103 LSNSIYVFVRDPAKLFL-----VDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLP 157
Query: 180 DGKRIIWDSRKGFIISNA--TYKEIGLLTCEATVNGH--LYKTNYLTHRQTNTIIDVQIS 235
R I D + G +I + Y + L C G L + L R + V +S
Sbjct: 158 KDLRFIPDPKAGIMIKSVKRAYHRL-CLHCSVDQEGKSVLSEKFILKVRPAFKAVPV-VS 215
Query: 236 TPRPVKLLR-GHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFY- 293
+ LLR G + CT +++ V TW +N + ++ + + S H + Y
Sbjct: 216 VSKASYLLREGEEFTVTCTIKD-VSSSVYSTWK---RENSQTKLQEKYN-SWHHGDFNYE 270
Query: 294 --SVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKR 351
+ LTI + D G++ C + +V T++ + DK FI + + G+
Sbjct: 271 RQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGE- 329
Query: 352 SYRLSMKVKAFPSPE-VVWLKDGLPATEKSARYLTRGYSLIIKDVTE--------EDAGN 402
+ L ++ +AFP PE W+ T+K Y I+ V+E + G
Sbjct: 330 NVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGT 389
Query: 403 YTILLSIKQSNVFKNLTATLIVNVKPQI--YEKAVSSFPDPALYPLGSRQILTCTAYGIP 460
YT L+S S+V + + VN KP+I Y++ V+ +L C A G P
Sbjct: 390 YTFLVS--NSDVNAAIAFNVYVNTKPEILTYDRLVNG-------------MLQCVAAGFP 434
Query: 461 QPTIKWFWHPCNHNHSEARC 480
+PTI W++ P +E RC
Sbjct: 435 EPTIDWYFCP----GTEQRC 450
Score = 38.1 bits (87), Expect = 0.029
Identities = 45/185 (24%), Positives = 78/185 (42%), Gaps = 25/185 (13%)
Query: 520 STLVVADSRI--SGIYICIASNKVGTVGRNISFYITDVPNGF-----HVNLEKMPTEGED 572
+TL ++ +R+ SG+++C A+N G+ N++ + V GF +N +GE+
Sbjct: 273 ATLTISSARVNDSGVFMCYANNTFGSA--NVTTTLEVVDKGFINIFPMINTTVFVNDGEN 330
Query: 573 LKLSCTVNKFLYRD-VTWILL-RTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQD 630
+ L F + WI + RT ++ Y S+ + I + L+LT + + +
Sbjct: 331 VDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNI--RYVSELHLTRLKGT--E 386
Query: 631 SGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEP 690
GTY N I + + + Y D V + L C A G PEP
Sbjct: 387 GGTYTFLVSNSDVNAAIAFNVYVNTKPEILTY------DRLV----NGMLQCVAAGFPEP 436
Query: 691 QITWF 695
I W+
Sbjct: 437 TIDWY 441
>gi|5453872 platelet-derived growth factor receptor-like protein
[Homo sapiens]
Length = 375
Score = 91.7 bits (226), Expect = 2e-18
Identities = 79/297 (26%), Positives = 141/297 (47%), Gaps = 27/297 (9%)
Query: 45 AGQTLHLQCRGEAAHKWSLPEMVSK-ESERLSITKSACGRNGKQFCSTLTLNTAQANHTG 103
AGQT+ L+C+G WS P + + RLS+ ++ R G+ LTL + + TG
Sbjct: 88 AGQTVELRCKGSRIG-WSYPAYLDTFKDSRLSVKQNE--RYGQ-----LTLVNSTSADTG 139
Query: 104 FYSC--KYLAVPTSKKKETES-AIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRV 160
+SC + + +K E ++ + YIF ++ G FV S +++++ R+ V+PCRV
Sbjct: 140 EFSCWVQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSYF-DVVYLNPDRQAVVPCRV 198
Query: 161 TSPNITVTL-KKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGH----- 214
T + VTL ++FP + +G I++D ++GF+ + G++ C A G
Sbjct: 199 TVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYLQPHSEHQGVVYCRAEAGGRSQISV 258
Query: 215 LYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNK 274
Y+ Y+ + S+ K+ G + + CT + V+ TW +P +K++
Sbjct: 259 KYQLLYVAVPSGPPSTTILASSN---KVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDE 315
Query: 275 R----ASVRRRIDQSNSH-ANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSV 326
R R I + H I SV+T++ + D G Y C ++ +V T+V
Sbjct: 316 RPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTTVATTV 372
>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
Length = 2623
Score = 90.9 bits (224), Expect = 4e-18
Identities = 157/727 (21%), Positives = 283/727 (38%), Gaps = 117/727 (16%)
Query: 32 PELSLKGTQHI-MQAGQTLHLQCRGEAAHKWSLPEMVSKESERLSITKSACGRNGKQFC- 89
P + + T+ I + +G T+ L+CR E ++ +++ ++ +++S+ G
Sbjct: 1745 PRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTV---VSESSQGSRQAVVTV 1801
Query: 90 -STLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHM 148
TL L+ GFY C + + ++ + I P V + + ++I
Sbjct: 1802 DGTLVLHNLSIYDRGFYKC------VASNPGGQDSLLVKIQVIAAPPV-ILEQRRQVIVG 1854
Query: 149 TEGRELVIPCRVTSPNITVTLKKFPLDTL---IPDG---KRIIWDSRKGFIISNATY--- 199
T G L +PC T K P ++ + DG K + + + K F+ SN T
Sbjct: 1855 TWGESLKLPC---------TAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIR 1905
Query: 200 ----KEIGLLTCEATVN-GHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTA 254
+ G C AT + G + LT + T ++ ++ + ++ G L+LNC+A
Sbjct: 1906 NLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSA 1965
Query: 255 TTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYS-VLTIDKMQNKDKGLYTCRV 313
T + Q+ W P + +V + + S +++ + L I + KD G+Y C
Sbjct: 1966 TG--EPKPQIMWRLPSK-----AVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVA 2018
Query: 314 RS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVW-L 370
R+ G ++ S+ + ++ ++QVL + +++ K P PE+ W L
Sbjct: 2019 RNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHG----KDFQVDCKASGSPVPEISWSL 2074
Query: 371 KDGLPATEK----SARYLTRGYSLI------IKDVTEEDAGNYTILL--SIKQSNVFKNL 418
DG + + TR Y+L V + G+YT ++ + + +L
Sbjct: 2075 PDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHL 2134
Query: 419 TATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEA 478
T ++ P+I + ++ A G +L C G P+P I W
Sbjct: 2135 T---VITAAPRIRQSNKTNKRIKA----GDTAVLDCEVTGDPKPKIFWL----------- 2176
Query: 479 RCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIAS 538
SN+ SF +D + N +I K K+ SG Y+C+A
Sbjct: 2177 ---LPSNDMISFSIDRYTFHANGSLTIN--------KVKLLD---------SGEYVCVAR 2216
Query: 539 NKVGTVGRNISFYITDVP---NGFHVN---LEKMPTEGEDLKLSCTVNKFLYRDVTWILL 592
N G + + P NG + N ++ C +V WI+
Sbjct: 2217 NPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMP 2276
Query: 593 RTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKE 652
+ +Y ++ + K + L I NV L DS + C ARN GE +L +
Sbjct: 2277 DNIFLTAPYYG---SRITVHKNGT----LEIRNVRLSDSADFICVARNE-GGESVLVVQL 2328
Query: 653 ITIRDQEAPYLLRNLSDHTVA-ISSSTTLDCHANGVPEPQITW-FKNNHKIQQEPELYTS 710
+ P ++ VA + ST L+C +G P P+I W N + P+ Y
Sbjct: 2329 EVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQY 2388
Query: 711 TSPSSSS 717
S+ S
Sbjct: 2389 LIASNGS 2395
Score = 70.1 bits (170), Expect = 7e-12
Identities = 149/694 (21%), Positives = 255/694 (36%), Gaps = 118/694 (17%)
Query: 46 GQTLHLQCRGEAAHK----WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANH 101
G L L C K W LP + + + NG F ++T
Sbjct: 1956 GDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVT-----EKD 2010
Query: 102 TGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEI--PEIIHMTEGRELVIPCR 159
+G Y C ++ K + I + +S +P + + +++H G++ + C+
Sbjct: 2011 SGVYLC------VARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLH---GKDFQVDCK 2061
Query: 160 VTSPNITVTLKKFPLDTLIPDGKRIIWD---SRKGFIISNAT--YKEIGLL-----TCEA 209
+ + P T+I + + +R+ + +N T + ++G+ TC A
Sbjct: 2062 ASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYA 2121
Query: 210 TVNGHLYKTNYLTHRQTNTIID-VQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSY 268
L K H T ++ S ++ G T VL+C T + + ++ W
Sbjct: 2122 --QNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTG--DPKPKIFWLL 2177
Query: 269 PDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVR--SGPSFKSVNTSV 326
P + ID+ HAN LTI+K++ D G Y C R SG K V
Sbjct: 2178 PSND----MISFSIDRYTFHAN---GSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDV 2230
Query: 327 HIYDKAFITVKHRKQQVLETVAGKRSYR-LSMKVKAFPSPEVVWLKDG---LPATEKSAR 382
+ I + + V++ A + S + + + PSPEV+W+ L A +R
Sbjct: 2231 -VSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSR 2289
Query: 383 YLT-RGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV-----S 436
+ +L I++V D+ ++ V +N ++ V+ ++ E +
Sbjct: 2290 ITVHKNGTLEIRNVRLSDSADFIC--------VARNEGGESVLVVQLEVLEMLRRPTFRN 2341
Query: 437 SFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADS 496
F + + LG L C+ G P P I W SN +S+ S
Sbjct: 2342 PFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTR---------FSNGPQSYQYLIAS 2392
Query: 497 NMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVP 556
N G+ I S T R +G Y C A NKVG + + + I P
Sbjct: 2393 N-GSFIISKTTR-------------------EDAGKYRCAARNKVGYIEKLVILEIGQKP 2432
Query: 557 NGFHVNLEKMP-----TEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAI 611
V L P GE L L C + ++ W TM + I
Sbjct: 2433 ----VILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW---------TMPSGYVVDRPQI 2479
Query: 612 TKEHSITLN--LTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSD 669
++ + N L I + D G Y C+A+N G ++ + + P + N
Sbjct: 2480 NGKYILHDNGTLVIKEATAYDRGNYICKAQNS-VGHTLIT---VPVMIVAYPPRITNRPP 2535
Query: 670 HTVAISSSTT--LDCHANGVPEPQITWFKNNHKI 701
++ + L C A GVP+P+ITW +H +
Sbjct: 2536 RSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSL 2569
Score = 58.9 bits (141), Expect = 2e-08
Identities = 67/271 (24%), Positives = 96/271 (35%), Gaps = 44/271 (16%)
Query: 427 KPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNN 486
KP+I +SF PA S L C A G P PTI W P
Sbjct: 1647 KPRIVGGKAASFTIPA----NSDAFLPCEAVGNPLPTIHWTRVPSG-------------- 1688
Query: 487 EESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGR 546
LD N R+ ++ + + D G Y+C ASN GT
Sbjct: 1689 -----LDLSKRKQN------SRVQVLPNGTLSIQRVEIQDR---GQYLCSASNLFGTDHL 1734
Query: 547 NISFYITDVPNGFHVNLEKMPT--EGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSI 604
+++ + P K T G ++L C VTWIL N + S
Sbjct: 1735 HVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWIL---ANQTVVSESS 1791
Query: 605 SKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLL 664
+ A+ ++ L + N+S+ D G Y C A N + +L K ++ P +L
Sbjct: 1792 QGSRQAVV---TVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVI---AAPPVIL 1845
Query: 665 RNLSDHTVAI-SSSTTLDCHANGVPEPQITW 694
V S L C A G P+P + W
Sbjct: 1846 EQRRQVIVGTWGESLKLPCTAKGTPQPSVYW 1876
Score = 55.8 bits (133), Expect = 1e-07
Identities = 143/691 (20%), Positives = 265/691 (38%), Gaps = 97/691 (14%)
Query: 46 GQTLHLQCRGEAAHKWSLPEMVSKESERLSITKSACGRNGKQFC---STLTLNTAQANHT 102
G++L L C + + S+ ++S +E K N K F TL + ++
Sbjct: 1857 GESLKLPCTAKGTPQPSVYWVLSDGTE----VKPLQFTNSKLFLFSNGTLYIRNLASSDR 1912
Query: 103 GFYSCKYLAVPTSKKKETESAIYIFISD-TGRPFVEMYSEIPEIIHMTEGRELVIPCRVT 161
G Y C + TS + + + + P +E S+ ++ G +L++ C T
Sbjct: 1913 GTYEC----IATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNF--GDKLLLNCSAT 1966
Query: 162 SPNITVTLKKFPLDTLIPDGKRI-----IWDSRKGFIISNATYKEIGLLTCEATVN-GHL 215
+ + P ++ R+ ++ + FI + T K+ G+ C A G
Sbjct: 1967 GEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFI-GSVTEKDSGVYLCVARNKMGDD 2025
Query: 216 YKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTAT-TPLNTRVQMTWSYPDEKNK 274
+++ R ID + + V L G ++C A+ +P+ +++WS PD
Sbjct: 2026 LILMHVSLRLKPAKIDHKQYFRKQV--LHGKDFQVDCKASGSPVP---EISWSLPDGTMI 2080
Query: 275 RASVRRRIDQSNSHANIFYSV-----LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIY 329
+++ + H Y++ L +K+ ++G YTC ++ + VH+
Sbjct: 2081 NNAMQA---DDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQN--TLGKDEMKVHL- 2134
Query: 330 DKAFITVKHRKQQVLET---VAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTR 386
IT R +Q +T + + L +V P P++ WL LP+ + + + R
Sbjct: 2135 --TVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWL---LPSNDMISFSIDR 2189
Query: 387 -----GYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDP 441
SL I V D+G Y + ++ S + +V+ P I +
Sbjct: 2190 YTFHANGSLTINKVKLLDSGEY-VCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIK 2248
Query: 442 ALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNR 501
A S++ C A G P P + W ++ L A G+R
Sbjct: 2249 ATAVRHSKKHFDCRAEGTPSPEVMWIM------------------PDNIFLTAPY-YGSR 2289
Query: 502 IESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDV---PNG 558
I + +E +N S S +IC+A N+ G + + ++ P
Sbjct: 2290 IT--VHKNGTLEIRNVRLSD--------SADFICVARNEGGESVLVVQLEVLEMLRRPTF 2339
Query: 559 FHVNLEKMPTE-GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSI 617
+ EK+ + G+ L+C+V+ ++ WIL N + I S
Sbjct: 2340 RNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWIL---PNGTRFSNGPQSYQYLIASNGSF 2396
Query: 618 TLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISS- 676
++ T + +D+G Y C ARN E L EI + P +L IS
Sbjct: 2397 IISKT----TREDAGKYRCAARNKVGYIEKLVILEIG----QKPVILTYAPGTVKGISGE 2448
Query: 677 STTLDCHANGVPEPQITWFKNNHKIQQEPEL 707
S +L C ++G+P+P I W + + P++
Sbjct: 2449 SLSLHCVSDGIPKPNIKWTMPSGYVVDRPQI 2479
Score = 54.7 bits (130), Expect = 3e-07
Identities = 70/296 (23%), Positives = 104/296 (35%), Gaps = 45/296 (15%)
Query: 351 RSYRLSMKVKAFPSPEVVW-LKDGLPATEKSARY---LTRGYSLIIKDVTEEDAGNYTIL 406
+S L+ V P PE++W L +G + Y + S II T EDAG Y
Sbjct: 2353 KSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCA 2412
Query: 407 LSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKW 466
K + K L + KP I A P G L C + GIP+P IKW
Sbjct: 2413 ARNKVGYIEK--LVILEIGQKPVILTYA----PGTVKGISGESLSLHCVSDGIPKPNIKW 2466
Query: 467 FWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVAD 526
+++D G I + I E A
Sbjct: 2467 ------------------TMPSGYVVDRPQINGKYILHDNGTLVIKE-----------AT 2497
Query: 527 SRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEK--MPTEGEDLKLSCTVNKFLY 584
+ G YIC A N VG + I P + + G +L C
Sbjct: 2498 AYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPK 2557
Query: 585 RDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
++TW + + ++ + SK++ +++ + L I N DSG Y C A+N
Sbjct: 2558 PEITW----EMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKN 2609
Score = 46.2 bits (108), Expect = 1e-04
Identities = 27/86 (31%), Positives = 39/86 (45%), Gaps = 6/86 (6%)
Query: 621 LTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAP--YLLRNLSDHTVAISSST 678
L+I V +QD G Y C A N++ + + +T+ P L R + TV S+
Sbjct: 1708 LSIQRVEIQDRGQYLCSASNLFGTDHL----HVTLSVVSYPPRILERRTKEITVHSGSTV 1763
Query: 679 TLDCHANGVPEPQITWFKNNHKIQQE 704
L C A G P P +TW N + E
Sbjct: 1764 ELKCRAEGRPSPTVTWILANQTVVSE 1789
Score = 39.7 bits (91), Expect = 0.010
Identities = 22/65 (33%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 630 DSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPE 689
D+G Y C + N Y +IL + IT+ + N HTV I + L CH+ G+P+
Sbjct: 545 DTGVYHCISSN-YDDADILTYR-ITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPD 602
Query: 690 PQITW 694
I+W
Sbjct: 603 ASISW 607
Score = 35.0 bits (79), Expect = 0.25
Identities = 49/233 (21%), Positives = 87/233 (37%), Gaps = 20/233 (8%)
Query: 179 PDGKRIIWDSRKGFIISNATYKEIGLLTCEATVN-GHLYKTNYLTHRQTNTIIDVQISTP 237
P + + S FIIS T ++ G C A G++ K L Q I+ P
Sbjct: 2383 PQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTY---AP 2439
Query: 238 RPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLT 297
VK + G +L L+C + ++ W+ P V R + + L
Sbjct: 2440 GTVKGISGESLSLHCVSDGIPKPNIK--WTMPS-----GYVVDRPQINGKYILHDNGTLV 2492
Query: 298 IDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSM 357
I + D+G Y C+ ++ + V I + +R + + T G +++L
Sbjct: 2493 IKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYP-PRITNRPPRSIVTRTG-AAFQLHC 2550
Query: 358 KVKAFPSPEVVWLKDGLPATEKSARYLTRGY-------SLIIKDVTEEDAGNY 403
P PE+ W +++ T G +L+I++ D+G Y
Sbjct: 2551 VALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIY 2603
Score = 34.7 bits (78), Expect = 0.32
Identities = 51/218 (23%), Positives = 81/218 (37%), Gaps = 26/218 (11%)
Query: 108 KYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPC---RVTSPN 164
KY +K E + + I +P + Y+ P + G L + C + PN
Sbjct: 2408 KYRCAARNKVGYIEKLVILEIGQ--KPVILTYA--PGTVKGISGESLSLHCVSDGIPKPN 2463
Query: 165 ITVTLKK-FPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVN-GHLYKTNYLT 222
I T+ + +D +GK I+ D+ +I AT + G C+A + GH T +
Sbjct: 2464 IKWTMPSGYVVDRPQINGKYILHDNGT-LVIKEATAYDRGNYICKAQNSVGHTLITVPVM 2522
Query: 223 -----HRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRAS 277
R TN PR + G L+C A + ++TW PD +
Sbjct: 2523 IVAYPPRITNR-------PPRSIVTRTGAAFQLHCVALGV--PKPEITWEMPDHSLLSTA 2573
Query: 278 VRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS 315
+ R S L I Q D G+Y C ++
Sbjct: 2574 SKERTHGSEQLH--LQGTLVIQNPQTSDSGIYKCTAKN 2609
Score = 33.1 bits (74), Expect = 0.94
Identities = 33/128 (25%), Positives = 51/128 (39%), Gaps = 25/128 (19%)
Query: 522 LVVADSRISGIYICIASN---------KVGTVGRNISFYITDVPNGFHVNLEKMPTEGED 572
L +ADS +G+Y CI+SN ++ V + Y NG H + GE
Sbjct: 538 LQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAY---QENGIHHTV----FIGET 590
Query: 573 LKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSG 632
L L C ++W+ + + Y S+ K + L I+ V+ +D G
Sbjct: 591 LDLPCHSTGIPDASISWV----IPGNNVLYQSSRDKKVLNNG-----TLRILQVTPKDQG 641
Query: 633 TYACRARN 640
Y C A N
Sbjct: 642 YYRCVAAN 649
>gi|7657359 contactin 5 isoform long [Homo sapiens]
Length = 1100
Score = 87.8 bits (216), Expect = 3e-17
Identities = 125/610 (20%), Positives = 230/610 (37%), Gaps = 91/610 (14%)
Query: 95 NTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISD-TGRPFVEMYSEIPEIIHMTEGRE 153
N ++A +G Y C S + + ++ + +GR + + EG+
Sbjct: 161 NPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRT--------RSAVSVREGQG 212
Query: 154 LVIPCRVT--SPNITVT--LKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTC-- 207
+V+ C SP I + +FP + D +R I IS ++G C
Sbjct: 213 VVLMCSPPPHSPEIIYSWVFNEFP-SFVAEDSRRFISQETGNLYISKVQTSDVGSYICLV 271
Query: 208 -EATVNGH-LYKTNYLTHRQTNTIID----VQISTPRPVKLLRGHTLVLNCTAT-TPLNT 260
N L LT R + + +++ P V +G T+ + C A P+ T
Sbjct: 272 KNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPT 331
Query: 261 RVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFK 320
+TW + N + R+ +S + VL I +Q D G+Y CR +
Sbjct: 332 ---ITWM---KVNGYIPSKARLRKSQA-------VLEIPNVQLDDAGIYECRAENSRGKN 378
Query: 321 SVNTSVHIYDKAFITVKHRKQQVLETVAGKRS-YRLSMKVKAFPSPEVVWLKDGLPATEK 379
S + +Y T H +++ +T S R K P P WLK+G+P + +
Sbjct: 379 SFRGQLQVY-----TYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQ 433
Query: 380 SARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFP 439
S + G L+I +V + DAG Y L K ++ + ++ + A++
Sbjct: 434 SRVEMVNGV-LMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAP----TFALNQLK 488
Query: 440 DPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMG 499
+ ++ C G P+PTI W G
Sbjct: 489 KTIIVTKDQEVVIECKPQGSPKPTISW------------------------------KKG 518
Query: 500 NRIESITQRMAII-EGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNG 558
+R +R+AI+ +G ++ + A G Y+C N G+ S + + P
Sbjct: 519 DRAVRENKRIAILPDGSLRILN----ASKSDEGKYVCRGENVFGSAEIIASLSVKE-PTR 573
Query: 559 FHVNLEKMP-TEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSI 617
+ ++ T GE + L+C DVT+ T+ + + + + +
Sbjct: 574 IELTPKRTELTVGESIVLNCKAIHDASLDVTFYW--TLKGQPIDFEEEGGHFESIRAQAS 631
Query: 618 TLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAP---YLLRNLSDHTVAI 674
+ +L I N+ L +G Y CR + T + + + E+ +R P ++ +++ T +
Sbjct: 632 SADLMIRNILLMHAGRYGCRVQT--TADSVSDEAELLVRGPPGPPGIVIVEEITESTATL 689
Query: 675 SSSTTLDCHA 684
S S D H+
Sbjct: 690 SWSPAADNHS 699
Score = 51.6 bits (122), Expect = 3e-06
Identities = 67/284 (23%), Positives = 109/284 (38%), Gaps = 50/284 (17%)
Query: 439 PDPALYPLGSRQ---ILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDAD 495
PD ++P S + L C G P P+ +W N L++D
Sbjct: 105 PDDIIFPTDSDEKKVALNCEVRGNPVPSYRWL-----------------RNGTEIDLESD 147
Query: 496 SNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTV-GRNISFYITD 554
R ++I+G +++ ++++ SG Y C+A+N VG++ R +
Sbjct: 148 -----------YRYSLIDGTFIISNP---SEAKDSGHYQCLATNTVGSILSREATLQFAY 193
Query: 555 VPN-GFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITK 613
+ N EG+ + L C+ I+ V N + + I++
Sbjct: 194 LGNFSGRTRSAVSVREGQGVVLMCSPPPHSPE----IIYSWVFNEFPSFVAEDSRRFISQ 249
Query: 614 EHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKE-ITIRDQ----EAPYLLRNLS 668
E T NL I V D G+Y C +N T +L +T+R+ E +
Sbjct: 250 E---TGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHF 306
Query: 669 DHTVAISSSTT--LDCHANGVPEPQITWFKNNHKIQQEPELYTS 710
TV + TT ++C A G P P ITW K N I + L S
Sbjct: 307 PFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKS 350
Score = 49.7 bits (117), Expect = 1e-05
Identities = 73/357 (20%), Positives = 124/357 (34%), Gaps = 64/357 (17%)
Query: 364 SPEVV--WLKDGLPA--TEKSARYLTRGY-SLIIKDVTEEDAGNYTILL--SIKQSNVFK 416
SPE++ W+ + P+ E S R++++ +L I V D G+Y L+ ++ + V
Sbjct: 223 SPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLS 282
Query: 417 NLTATLIVN--VKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHN 474
T + N V + K FP G+ + C A G P PTI W +
Sbjct: 283 PPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWM-KVNGYI 341
Query: 475 HSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYI 534
S+AR + + A++E N +GIY
Sbjct: 342 PSKAR-------------------------LRKSQAVLEIPNVQLDD--------AGIYE 368
Query: 535 CIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRT 594
C A N G + P+ + G L+ C W+
Sbjct: 369 CRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWL---- 424
Query: 595 VNNRTMHYSISKQKMAITKEHSITLN---LTIMNVSLQDSGTYACRARNVYTGEEILQKK 651
K + ++ + + + L I NV+ D+G Y C A N Y I
Sbjct: 425 -----------KNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGA--IYASA 471
Query: 652 EITIRDQEAPYLLRNLSDHTVAISSS-TTLDCHANGVPEPQITWFKNNHKIQQEPEL 707
E+ I + L L + ++C G P+P I+W K + +++ +
Sbjct: 472 ELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRI 528
Score = 42.4 bits (98), Expect = 0.002
Identities = 81/369 (21%), Positives = 130/369 (35%), Gaps = 65/369 (17%)
Query: 343 VLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPAT-EKSARYLTRGYSLIIKDVTE-EDA 400
+ T + ++ L+ +V+ P P WL++G E RY + II + +E +D+
Sbjct: 109 IFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDS 168
Query: 401 GNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIP 460
G+Y L + ++ ATL + S+ G +L C+ P
Sbjct: 169 GHYQCLATNTVGSILSR-EATLQFAYLGNFSGRTRSAVSVRE----GQGVVLMCS----P 219
Query: 461 QPTIKWFWHPCNHNHS-EARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMA 519
P HS E + N SF+ + ++R E N
Sbjct: 220 PP------------HSPEIIYSWVFNEFPSFVAED-----------SRRFISQETGNLYI 256
Query: 520 STLVVADSRISGIYICIASNKVGTVG----------RNISFYITDVPN-GFHVNLEKMPT 568
S + +D G YIC+ N V RN P H
Sbjct: 257 SKVQTSDV---GSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAA 313
Query: 569 EGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSL 628
+G +K+ C +TW+ + Y SK ++ K ++ L I NV L
Sbjct: 314 KGTTVKMECFALGNPVPTITWM-------KVNGYIPSKARLR--KSQAV---LEIPNVQL 361
Query: 629 QDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVP 688
D+G Y CRA N + ++ P+ + L+D + S +C A G P
Sbjct: 362 DDAGIYECRAENSRGKNSFRGQLQV----YTYPHWVEKLNDTQLDSGSPLRWECKATGKP 417
Query: 689 EPQITWFKN 697
P W KN
Sbjct: 418 RPTYRWLKN 426
Score = 38.9 bits (89), Expect = 0.017
Identities = 54/237 (22%), Positives = 95/237 (40%), Gaps = 38/237 (16%)
Query: 92 LTLNTAQANHTGFYSC----KYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIH 147
L ++ + G Y C KY A+ S + + ++ F +++ + I
Sbjct: 443 LMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFA----------LNQLKKTII 492
Query: 148 MTEGRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLT 206
+T+ +E+VI C+ SP T++ KK D + + KRI I NA+ + G
Sbjct: 493 VTKDQEVVIECKPQGSPKPTISWKKG--DRAVRENKRIAILPDGSLRILNASKSDEGKYV 550
Query: 207 CEA-TVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMT 265
C V G L+ ++ I TP+ +L G ++VLNC A + V
Sbjct: 551 CRGENVFGSAEIIASLSVKEPTRIE----LTPKRTELTVGESIVLNCKAIHDASLDVTFY 606
Query: 266 WS-------YPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS 315
W+ + +E S+R + ++ L I + G Y CRV++
Sbjct: 607 WTLKGQPIDFEEEGGHFESIRAQASSAD---------LMIRNILLMHAGRYGCRVQT 654
>gi|28373129 contactin 5 isoform short [Homo sapiens]
Length = 1026
Score = 87.8 bits (216), Expect = 3e-17
Identities = 125/610 (20%), Positives = 230/610 (37%), Gaps = 91/610 (14%)
Query: 95 NTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISD-TGRPFVEMYSEIPEIIHMTEGRE 153
N ++A +G Y C S + + ++ + +GR + + EG+
Sbjct: 87 NPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRT--------RSAVSVREGQG 138
Query: 154 LVIPCRVT--SPNITVT--LKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTC-- 207
+V+ C SP I + +FP + D +R I IS ++G C
Sbjct: 139 VVLMCSPPPHSPEIIYSWVFNEFP-SFVAEDSRRFISQETGNLYISKVQTSDVGSYICLV 197
Query: 208 -EATVNGH-LYKTNYLTHRQTNTIID----VQISTPRPVKLLRGHTLVLNCTAT-TPLNT 260
N L LT R + + +++ P V +G T+ + C A P+ T
Sbjct: 198 KNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPT 257
Query: 261 RVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFK 320
+TW + N + R+ +S + VL I +Q D G+Y CR +
Sbjct: 258 ---ITWM---KVNGYIPSKARLRKSQA-------VLEIPNVQLDDAGIYECRAENSRGKN 304
Query: 321 SVNTSVHIYDKAFITVKHRKQQVLETVAGKRS-YRLSMKVKAFPSPEVVWLKDGLPATEK 379
S + +Y T H +++ +T S R K P P WLK+G+P + +
Sbjct: 305 SFRGQLQVY-----TYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQ 359
Query: 380 SARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFP 439
S + G L+I +V + DAG Y L K ++ + ++ + A++
Sbjct: 360 SRVEMVNGV-LMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAP----TFALNQLK 414
Query: 440 DPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMG 499
+ ++ C G P+PTI W G
Sbjct: 415 KTIIVTKDQEVVIECKPQGSPKPTISW------------------------------KKG 444
Query: 500 NRIESITQRMAII-EGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNG 558
+R +R+AI+ +G ++ + A G Y+C N G+ S + + P
Sbjct: 445 DRAVRENKRIAILPDGSLRILN----ASKSDEGKYVCRGENVFGSAEIIASLSVKE-PTR 499
Query: 559 FHVNLEKMP-TEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSI 617
+ ++ T GE + L+C DVT+ T+ + + + + +
Sbjct: 500 IELTPKRTELTVGESIVLNCKAIHDASLDVTFYW--TLKGQPIDFEEEGGHFESIRAQAS 557
Query: 618 TLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAP---YLLRNLSDHTVAI 674
+ +L I N+ L +G Y CR + T + + + E+ +R P ++ +++ T +
Sbjct: 558 SADLMIRNILLMHAGRYGCRVQT--TADSVSDEAELLVRGPPGPPGIVIVEEITESTATL 615
Query: 675 SSSTTLDCHA 684
S S D H+
Sbjct: 616 SWSPAADNHS 625
Score = 51.6 bits (122), Expect = 3e-06
Identities = 67/284 (23%), Positives = 109/284 (38%), Gaps = 50/284 (17%)
Query: 439 PDPALYPLGSRQ---ILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDAD 495
PD ++P S + L C G P P+ +W N L++D
Sbjct: 31 PDDIIFPTDSDEKKVALNCEVRGNPVPSYRWL-----------------RNGTEIDLESD 73
Query: 496 SNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTV-GRNISFYITD 554
R ++I+G +++ ++++ SG Y C+A+N VG++ R +
Sbjct: 74 -----------YRYSLIDGTFIISNP---SEAKDSGHYQCLATNTVGSILSREATLQFAY 119
Query: 555 VPN-GFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITK 613
+ N EG+ + L C+ I+ V N + + I++
Sbjct: 120 LGNFSGRTRSAVSVREGQGVVLMCSPPPHSPE----IIYSWVFNEFPSFVAEDSRRFISQ 175
Query: 614 EHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKE-ITIRDQ----EAPYLLRNLS 668
E T NL I V D G+Y C +N T +L +T+R+ E +
Sbjct: 176 E---TGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHF 232
Query: 669 DHTVAISSSTT--LDCHANGVPEPQITWFKNNHKIQQEPELYTS 710
TV + TT ++C A G P P ITW K N I + L S
Sbjct: 233 PFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKS 276
Score = 49.7 bits (117), Expect = 1e-05
Identities = 73/357 (20%), Positives = 124/357 (34%), Gaps = 64/357 (17%)
Query: 364 SPEVV--WLKDGLPA--TEKSARYLTRGY-SLIIKDVTEEDAGNYTILL--SIKQSNVFK 416
SPE++ W+ + P+ E S R++++ +L I V D G+Y L+ ++ + V
Sbjct: 149 SPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLS 208
Query: 417 NLTATLIVN--VKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHN 474
T + N V + K FP G+ + C A G P PTI W +
Sbjct: 209 PPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWM-KVNGYI 267
Query: 475 HSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYI 534
S+AR + + A++E N +GIY
Sbjct: 268 PSKAR-------------------------LRKSQAVLEIPNVQLDD--------AGIYE 294
Query: 535 CIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRT 594
C A N G + P+ + G L+ C W+
Sbjct: 295 CRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWL---- 350
Query: 595 VNNRTMHYSISKQKMAITKEHSITLN---LTIMNVSLQDSGTYACRARNVYTGEEILQKK 651
K + ++ + + + L I NV+ D+G Y C A N Y I
Sbjct: 351 -----------KNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGA--IYASA 397
Query: 652 EITIRDQEAPYLLRNLSDHTVAISSS-TTLDCHANGVPEPQITWFKNNHKIQQEPEL 707
E+ I + L L + ++C G P+P I+W K + +++ +
Sbjct: 398 ELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRI 454
Score = 42.4 bits (98), Expect = 0.002
Identities = 81/369 (21%), Positives = 130/369 (35%), Gaps = 65/369 (17%)
Query: 343 VLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPAT-EKSARYLTRGYSLIIKDVTE-EDA 400
+ T + ++ L+ +V+ P P WL++G E RY + II + +E +D+
Sbjct: 35 IFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDS 94
Query: 401 GNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIP 460
G+Y L + ++ ATL + S+ G +L C+ P
Sbjct: 95 GHYQCLATNTVGSILSR-EATLQFAYLGNFSGRTRSAVSVRE----GQGVVLMCS----P 145
Query: 461 QPTIKWFWHPCNHNHS-EARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMA 519
P HS E + N SF+ + ++R E N
Sbjct: 146 PP------------HSPEIIYSWVFNEFPSFVAED-----------SRRFISQETGNLYI 182
Query: 520 STLVVADSRISGIYICIASNKVGTVG----------RNISFYITDVPN-GFHVNLEKMPT 568
S + +D G YIC+ N V RN P H
Sbjct: 183 SKVQTSDV---GSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAA 239
Query: 569 EGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSL 628
+G +K+ C +TW+ + Y SK ++ K ++ L I NV L
Sbjct: 240 KGTTVKMECFALGNPVPTITWM-------KVNGYIPSKARLR--KSQAV---LEIPNVQL 287
Query: 629 QDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVP 688
D+G Y CRA N + ++ P+ + L+D + S +C A G P
Sbjct: 288 DDAGIYECRAENSRGKNSFRGQLQV----YTYPHWVEKLNDTQLDSGSPLRWECKATGKP 343
Query: 689 EPQITWFKN 697
P W KN
Sbjct: 344 RPTYRWLKN 352
Score = 38.9 bits (89), Expect = 0.017
Identities = 54/237 (22%), Positives = 95/237 (40%), Gaps = 38/237 (16%)
Query: 92 LTLNTAQANHTGFYSC----KYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIH 147
L ++ + G Y C KY A+ S + + ++ F +++ + I
Sbjct: 369 LMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFA----------LNQLKKTII 418
Query: 148 MTEGRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLT 206
+T+ +E+VI C+ SP T++ KK D + + KRI I NA+ + G
Sbjct: 419 VTKDQEVVIECKPQGSPKPTISWKKG--DRAVRENKRIAILPDGSLRILNASKSDEGKYV 476
Query: 207 CEA-TVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMT 265
C V G L+ ++ I TP+ +L G ++VLNC A + V
Sbjct: 477 CRGENVFGSAEIIASLSVKEPTRIE----LTPKRTELTVGESIVLNCKAIHDASLDVTFY 532
Query: 266 WS-------YPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS 315
W+ + +E S+R + ++ L I + G Y CRV++
Sbjct: 533 WTLKGQPIDFEEEGGHFESIRAQASSAD---------LMIRNILLMHAGRYGCRVQT 580
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 85.5 bits (210), Expect = 2e-16
Identities = 100/421 (23%), Positives = 164/421 (38%), Gaps = 67/421 (15%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
L + + Q+ D G+YTC+ + T + +Y I + V++ VAG R L
Sbjct: 367 LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAG-RPVAL 425
Query: 356 SMKVKAFPSPEVVWLKDGLPATEKS-ARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNV 414
+ PSP + W +GLP E + +R T G L ++ E +G Y+ + S
Sbjct: 426 ECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEA 485
Query: 415 FKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHN 474
L ++ V V PQ+ V+ +G L C A G P PTI+W +
Sbjct: 486 V--LQYSVEVQVPPQL---LVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQN----- 535
Query: 475 HSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRI--SGI 532
G E + +G +TL + + SG+
Sbjct: 536 ------------------------GRPAEELAGVQVASQG-----TTLHIDHVELDHSGL 566
Query: 533 YICIASNKVGTVGRNISFY--------ITDVPNG-FHVNLEKMPTEGEDLKLSCTVNKFL 583
+ C A+N+ GT G + + +VP G +H E + +
Sbjct: 567 FACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXE------HHSSFPAACDPPV 620
Query: 584 YRDVTW---ILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
+R W V S+ + I +S+ L I V L+D G Y C A N
Sbjct: 621 HRG--WGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATN 678
Query: 641 VYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHK 700
+ GE K+E+ ++ P + + V ++S TL+C A+GVP P ++WFK +
Sbjct: 679 L-AGE---SKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQP 734
Query: 701 I 701
+
Sbjct: 735 V 735
Score = 84.3 bits (207), Expect = 4e-16
Identities = 99/397 (24%), Positives = 146/397 (36%), Gaps = 70/397 (17%)
Query: 307 GLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRK-----QQVLETVAGKRSYRLSMKVKA 361
G YTC R N++ + F+TV+ V+ VA + L +
Sbjct: 2732 GRYTCSAR--------NSAGVAHKHVFLTVQASPVVKPLPSVVRAVA-EEEVLLPCEASG 2782
Query: 362 FPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTAT 421
P P + W K+GL + + G L I + EDAGNY L I +++ + T
Sbjct: 2783 IPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNY---LCIAKNSAGSAMGKT 2839
Query: 422 LIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCD 481
+V P + E + PD + GS L C A G P+P I W
Sbjct: 2840 RLVVQVPPVIENGL---PDLSTTE-GSHAFLPCKARGSPEPNITW--------------- 2880
Query: 482 FCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKV 541
D D G + + I + L D+ G Y C A N V
Sbjct: 2881 -----------DKD---GQPVSGAEGKFTIQPSGELLVKNLEGQDA---GTYTCTAENAV 2923
Query: 542 GTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMH 601
G R + I +P + ++ G+ L L C + W TVN+R +
Sbjct: 2924 GRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGW----TVNDRPVT 2979
Query: 602 YSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAP 661
+S+Q T + + VS +DSGTY C A N + + + +EAP
Sbjct: 2980 EGVSEQDGGSTLQRAA--------VSREDSGTYVCWAENRVGRTQAVS----FVHVKEAP 3027
Query: 662 YLLRNLSDHTV-AISSSTTLDCHANGVPEPQITWFKN 697
L + V + S LDC G P P I W K+
Sbjct: 3028 VLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKD 3064
Score = 80.9 bits (198), Expect = 4e-15
Identities = 136/665 (20%), Positives = 247/665 (37%), Gaps = 133/665 (20%)
Query: 91 TLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTE 150
+L + AQA HTG YSC +A + + E + + + + E+ ++ + ++T
Sbjct: 1122 SLHVERAQAAHTGRYSC--VAENLAGRAERKFELSVLVPP------ELIGDLDPLTNITA 1173
Query: 151 GRE--LVIPCR---VTSPNITVTLKKFPL----DTLIPDGKRIIWDSRKGFIISNATYKE 201
L + C + P I + P+ DT + G ++ ++ ++
Sbjct: 1174 ALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLK-------MTQTQEQD 1226
Query: 202 IGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTR 261
GL +C A+ + N+ I+ + +K+L G T L C T + +
Sbjct: 1227 SGLYSCLASNEAGEARRNFSVEVLVPPSIENE-DLEEVIKVLDGQTAHLMCNVTG--HPQ 1283
Query: 262 VQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS--GPSF 319
++TW R H + +L + + G Y+C + G
Sbjct: 1284 PKLTWFKDGRPLARGDAH--------HISPDGVLLQVLQANLSSAGHYSCIAANAVGEKT 1335
Query: 320 KSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLP-ATE 378
K SV + + + + TV L + AFPSP + W+KDG P
Sbjct: 1336 KHFQLSVLLAPTILGGAEDSADEEV-TVTVNNPISLICEALAFPSPNITWMKDGAPFEAS 1394
Query: 379 KSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSF 438
++ + L + L I + +EDAG YT +++ + KN +++ P I +
Sbjct: 1395 RNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLI--PPSISK------ 1446
Query: 439 PDPALYPLGSRQILT---------CTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEES 489
D L +G +++ T C ++ +P PTI+W+
Sbjct: 1447 -DDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWY---------------------- 1483
Query: 490 FILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNIS 549
G + ++ + EG+ V+DS G Y+C+A+N G ++ +
Sbjct: 1484 -------KDGQPVTPSSRLQVLGEGRLLQIQPTQVSDS---GRYLCVATNVAGEDDQDFN 1533
Query: 550 FYITDVP-----NGFHVNLEKMPTEGE---------------DLKLSCTVNKFLYRDVTW 589
I P F E + E E L C N D+TW
Sbjct: 1534 VLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTW 1593
Query: 590 ILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSL---QDSGTYACRARNVYTGEE 646
Q ++ E S+ ++ + L +++G Y+C+A N GE+
Sbjct: 1594 YR-------------EDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNE-VGED 1639
Query: 647 ILQKKEITIRDQEAPYLLRN----LSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQ 702
L + + + P +L + + + TV SS+ +L C A G P P I+W +N
Sbjct: 1640 WLHYELLVLTP---PVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFS 1696
Query: 703 QEPEL 707
P L
Sbjct: 1697 PSPRL 1701
Score = 80.5 bits (197), Expect = 5e-15
Identities = 94/409 (22%), Positives = 151/409 (36%), Gaps = 75/409 (18%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
L I K+Q D G++TC S N ++ + + + V+ V L
Sbjct: 2178 LRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVV--VVRGSLVEL 2235
Query: 356 SMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVF 415
+ + P P V W+KDG P +S L +G SL ++ V D+G Y+ + +
Sbjct: 2236 PCEARGVPLPLVSWMKDGEPLLSQS---LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEAR 2292
Query: 416 KNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNH 475
++ T++ P I + S P G+ L C A G PQP I W H
Sbjct: 2293 RHFQLTVME--PPHIED---SGQPTELSLTPGAPMELLCDAQGTPQPNITW--------H 2339
Query: 476 SEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYIC 535
+ Q + +E ++ L V D+ G+Y C
Sbjct: 2340 KDG----------------------------QALTRLENNSRATRVLRVRDA---GLYTC 2368
Query: 536 IASNKVGTVGRNISFYITDVPN-------GFHVNLEKMPTEGEDLKLSCTVNKFLYRDVT 588
+A + G + ++ + PN F V L L L C+V +T
Sbjct: 2369 LAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAP-----GQLVLECSVEAEPAPKIT 2423
Query: 589 WILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEIL 648
W I Q+ A T+ L + +S DSG Y+C ARN +
Sbjct: 2424 W----------HRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVA 2473
Query: 649 QKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKN 697
+ EI P + V+++ + L C A+GVP P ++W K+
Sbjct: 2474 FRVEI----HTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKD 2518
Score = 80.1 bits (196), Expect = 7e-15
Identities = 86/371 (23%), Positives = 134/371 (36%), Gaps = 65/371 (17%)
Query: 344 LETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTR-GYSLIIKDVTEEDAGN 402
L T G ++ L K + P P + W KDG P + ++ + L++K++ +DAG
Sbjct: 2856 LSTTEGSHAF-LPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGT 2914
Query: 403 YTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQP 462
YT + + T++V ++ P LG R L C A G P P
Sbjct: 2915 YTCTAENAVGRARRRVHLTILVL-------PVFTTLPGDRSLRLGDRLWLRCAARGSPTP 2967
Query: 463 TIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTL 522
I W + +R +T+ ++ +G + +
Sbjct: 2968 RIGW------------------------------TVNDR--PVTEGVSEQDGGSTLQRAA 2995
Query: 523 VVADSRISGIYICIASNKVGTVGRNISFYITDVP----NGFHVNLEKMPTEGEDLKLSCT 578
V + SG Y+C A N+VG ++ + P F +E + G ++L C
Sbjct: 2996 VSRED--SGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPV---GGSIQLDCV 3050
Query: 579 VNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRA 638
V D+ WI + R H Q + LTI D+G Y C A
Sbjct: 3051 VRGDPVPDIHWIK-DGLPLRGSHLRHQLQNGS----------LTIHRTERDDAGRYQCLA 3099
Query: 639 RNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNN 698
N E + KK + + Q AP D TV L C A G P P I W +
Sbjct: 3100 EN----EMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAG 3155
Query: 699 HKIQQEPELYT 709
++ L T
Sbjct: 3156 QPLRASRRLRT 3166
Score = 77.4 bits (189), Expect = 4e-14
Identities = 99/426 (23%), Positives = 170/426 (39%), Gaps = 69/426 (16%)
Query: 296 LTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSY 353
L I + Q DKGLY+C+V + G + ++ +V + T ++ K + + VAG
Sbjct: 1897 LEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPP----TFENPKTETVSQVAGSPLV 1952
Query: 354 RLSMKVKAFPSPEVVWLKDGLPATEKSAR-YLTRGYSLIIKDVTEEDAGNYTILLSIKQS 412
L+ V P+P V WLKD +P + ++RG L + + AG YT + Q+
Sbjct: 1953 -LTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQA 2011
Query: 413 NVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQI-LTCTAYGIPQPTIKWFWHPC 471
K+ ++V P+I V+ + L +++ L C A G P P + W
Sbjct: 2012 EARKDFVVAVLV--APRIRSSGVAR----EHHVLEGQEVRLDCEADGQPPPDVAWL---- 2061
Query: 472 NHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISG 531
++ L D MG + ++G + + L +D+ G
Sbjct: 2062 ---------------KDGSPLGQD--MGPHLRFY------LDGGSLVLKGLRASDA---G 2095
Query: 532 IYICIASNKVGTVGRNISFYITDVPN---GFHVNLEKMPTEGEDLKLSCTVNKFLYRDVT 588
Y C+A N G R + + P G + + GE + + C V V+
Sbjct: 2096 AYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVS 2155
Query: 589 WILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEIL 648
W+ + +S++ + H+ L I V L D+G + C V +
Sbjct: 2156 WL------KDGLPLPLSQRTLLHGSGHT----LRISKVQLADAGIFTC----VAASPAGV 2201
Query: 649 QKKEITIRDQEAPYL--LRNLSDHTVAISSSTTLDCHANGVPEPQITWFKN-----NHKI 701
+ T++ Q P L + +D V S L C A GVP P ++W K+ + +
Sbjct: 2202 ADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSL 2261
Query: 702 QQEPEL 707
+Q P L
Sbjct: 2262 EQGPSL 2267
Score = 77.0 bits (188), Expect = 6e-14
Identities = 80/360 (22%), Positives = 138/360 (38%), Gaps = 59/360 (16%)
Query: 352 SYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRG-YSLIIKDVTEEDAGNYTILLSIK 410
S L V A P+PEV W KD + +L G ++L + D+G YT
Sbjct: 1763 SVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNA 1822
Query: 411 QSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHP 470
K + +++V P + +A D L +G + +L+C +P+PT+ W+
Sbjct: 1823 AGRDQKLVQLSVLV---PPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWY--- 1876
Query: 471 CNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS 530
+ + +L QR + G + L + ++++S
Sbjct: 1877 --------------KDGQPLVL-------------AQRTQALRGGQR----LEIQEAQVS 1905
Query: 531 --GIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMP-TEGEDLKLSCTVNKFLYRDV 587
G+Y C SN G R + + P + E + G L L+C V+ V
Sbjct: 1906 DKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTV 1965
Query: 588 TWILLRT-VNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEE 646
TW+ R V + +H +S+ L + + +GTY C A N +
Sbjct: 1966 TWLKDRMPVESSAVHGVVSRGG-----------RLQLSRLQPAQAGTYTCVAENT----Q 2010
Query: 647 ILQKKEITIRDQEAPYLLRN--LSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE 704
+K+ + AP + + +H V LDC A+G P P + W K+ + Q+
Sbjct: 2011 AEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQD 2070
Score = 77.0 bits (188), Expect = 6e-14
Identities = 140/654 (21%), Positives = 248/654 (37%), Gaps = 111/654 (16%)
Query: 69 KESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFI 128
K+S+ LS+ + G TL L A+ + +G Y+C+ L +K + ++ +
Sbjct: 1782 KDSQALSLGEEVFLLPGTH---TLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLV-- 1836
Query: 129 SDTGRPFVEMYSEIPE-IIHMTEGRELVIPCRVTS-PNITVTLKKFPLDTLIPDGKRIIW 186
P P+ + + G + V+ C + P TVT K DG+ ++
Sbjct: 1837 ----PPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYK--------DGQPLVL 1884
Query: 187 DSRKGFI-------ISNATYKEIGLLTCEAT-VNGHLYKTNYLTHRQTNTIIDVQISTPR 238
R + I A + GL +C+ + V G +T LT + T + + T
Sbjct: 1885 AQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTET-- 1942
Query: 239 PVKLLRGHTLVLNCTAT-TPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLT 297
V + G LVL C + P T +TW + ++V + + L
Sbjct: 1943 -VSQVAGSPLVLTCDVSGVPAPT---VTWLKDRMPVESSAVHGVVSRGGR--------LQ 1990
Query: 298 IDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
+ ++Q G YTC + + K +V + + + R+ VLE + RL
Sbjct: 1991 LSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEG----QEVRL 2046
Query: 356 SMKVKAFPSPEVVWLKDGLPATEKSA---RYLTRGYSLIIKDVTEEDAGNYTILLSIKQS 412
+ P P+V WLKDG P + R+ G SL++K + DAG YT +
Sbjct: 2047 DCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAG 2106
Query: 413 NVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCN 472
+ T ++ V P I + A S + G + C G P + W
Sbjct: 2107 EDARLHTVNVL--VPPTIKQGADGS--GTLVSRPGELVTMVCPVRGSPPIHVSWL----- 2157
Query: 473 HNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAII-EGKNKMASTLVVADSRISG 531
++ L ++QR + G S + +AD +G
Sbjct: 2158 --------------KDGLPL-----------PLSQRTLLHGSGHTLRISKVQLAD---AG 2189
Query: 532 IYICIASNKVGTVGRNISFYITDVPNGFHVNLEK--MPTEGEDLKLSCTVNKFLYRDVTW 589
I+ C+A++ G RN + + P V + + G ++L C V+W
Sbjct: 2190 IFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSW 2249
Query: 590 ILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQ 649
+ + ++ + E +L L V DSGTY+C A V E +
Sbjct: 2250 M------------KDGEPLLSQSLEQGPSLQLEA--VGAGDSGTYSCVA--VSEAGEARR 2293
Query: 650 KKEITIRDQEAPYLLRNLSDHTVAISSSTTLD--CHANGVPEPQITWFKNNHKI 701
++T+ E P++ + ++++ ++ C A G P+P ITW K+ +
Sbjct: 2294 HFQLTV--MEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL 2345
Score = 76.6 bits (187), Expect = 7e-14
Identities = 97/426 (22%), Positives = 160/426 (37%), Gaps = 75/426 (17%)
Query: 288 HANIFYSVLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLE 345
H + +L + + Q +G YTC + G S + + VH+ + R+
Sbjct: 1021 HVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQI---AGPREPPTQV 1077
Query: 346 TVAGKRSYRLSMKVKAFPSPEVVWLKDGLPA-TEKSARYLTRGYSLIIKDVTEEDAGNYT 404
+V L P P V W +DG P E + +G SL ++ G Y+
Sbjct: 1078 SVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYS 1137
Query: 405 ILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALY---PLGSRQILTCTAYGIPQ 461
+ + +++V P++ DP L S L C A GIP
Sbjct: 1138 CVAENLAGRAERKFELSVLV--PPELIGDL-----DPLTNITAALHSPLTLLCEAMGIPP 1190
Query: 462 PTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMAST 521
P I+WF + S E++++L G + +TQ
Sbjct: 1191 PAIRWFRGE----------EPVSPGEDTYLL-----AGGWMLKMTQ-------------- 1221
Query: 522 LVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKM--PTEGEDLKLSCTV 579
+ SG+Y C+ASN+ G RN S + P+ + +LE++ +G+ L C V
Sbjct: 1222 ---TQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNV 1278
Query: 580 NKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSIT---LNLTIMNVSLQDSGTYAC 636
+TW + +A H I+ + L ++ +L +G Y+C
Sbjct: 1279 TGHPQPKLTWFK-------------DGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSC 1325
Query: 637 RARNVYTGEEILQKKEITIRDQEAPYLLRNLSDH-----TVAISSSTTLDCHANGVPEPQ 691
A N GE + K + AP +L D TV +++ +L C A P P
Sbjct: 1326 IAANA-VGE---KTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPN 1381
Query: 692 ITWFKN 697
ITW K+
Sbjct: 1382 ITWMKD 1387
Score = 74.7 bits (182), Expect = 3e-13
Identities = 145/648 (22%), Positives = 231/648 (35%), Gaps = 115/648 (17%)
Query: 94 LNTAQAN--HTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEG 151
L QAN G YSC +A +K + + ++ T E ++ E + +T
Sbjct: 1310 LQVLQANLSSAGHYSC--IAANAVGEKTKHFQLSVLLAPTILGGAEDSAD--EEVTVTVN 1365
Query: 152 RELVIPCRVT---SPNITVTLKKFPLDTLIPDGKRI-IWDSRKGFIISNATYKEIGLLTC 207
+ + C SPNIT P + + I + G I NA ++ G TC
Sbjct: 1366 NPISLICEALAFPSPNITWMKDGAPFEA----SRNIQLLPGTHGLQILNAQKEDAGQYTC 1421
Query: 208 EATVNGHLYKTNYLTHRQTNTIIDVQISTPRP--------VKLLRGHTLVLNCT--ATTP 257
T NY +I IS P VK TL L C A P
Sbjct: 1422 VVTNELGEAVKNY----HVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPP 1477
Query: 258 LNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS-- 315
R W Y D + S R ++ +L I Q D G Y C +
Sbjct: 1478 PTIR----W-YKDGQPVTPSSRLQVLGEGR-------LLQIQPTQVSDSGRYLCVATNVA 1525
Query: 316 GPSFKSVNTSVHI---------YDKAFITVKHRKQ------QVLETVAGKRSYRLSMKVK 360
G + N + + + AF + ++ + E V +Y L
Sbjct: 1526 GEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAY-LYCDTN 1584
Query: 361 AFPSPEVVWLKDGLPATE-KSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSN-VFKNL 418
A P P++ W ++ P + L G L I V E+AG Y S K SN V ++
Sbjct: 1585 AIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRY----SCKASNEVGEDW 1640
Query: 419 TATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEA 478
++ + P + + S L C A G P PTI W
Sbjct: 1641 LHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWL----------- 1689
Query: 479 RCDFCSNNEESFILDADSNMGNRIESITQRMAIIE-GKNKMASTLVVADSRISGIYICIA 537
N F S + R+ ++E G+ ST VAD+ Y+C+A
Sbjct: 1690 ------QNGLPF-------------SPSPRLQVLEDGQVLQVSTAEVADA---ASYMCVA 1727
Query: 538 SNKVGTVGRNISFYITDVPNGFHVNLEKMPTE-GEDLKLSCTVNKFLYRDVTWILLRTVN 596
N+ G+ + + + P ++LE++ + L C V+ +VTW
Sbjct: 1728 ENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWY------ 1781
Query: 597 NRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIR 656
+ S+ ++ + H++ L L DSG Y C A N ++ L + + +
Sbjct: 1782 KDSQALSLGEEVFLLPGTHTLQLG----RARLSDSGMYTCEALNAAGRDQKLVQLSVLVP 1837
Query: 657 D--QEAPYLLRNLSDHT-VAISSSTTLDCHANGVPEPQITWFKNNHKI 701
++AP R D V + L C + +PEP +TW+K+ +
Sbjct: 1838 PAFRQAP---RGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPL 1882
Score = 73.6 bits (179), Expect = 6e-13
Identities = 101/416 (24%), Positives = 148/416 (35%), Gaps = 66/416 (15%)
Query: 296 LTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSY 353
L I+K+ +D+G+YTC + G S + V K + V + V S
Sbjct: 659 LQIEKVDLRDEGIYTCAATNLAGESKREVAL------KVLVPPNIEPGPVNKAVLENASV 712
Query: 354 RLSMKVKAFPSPEVVWLKDGLPATE-KSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQS 412
L P P+V W K P + G L I+ DAG+Y + S
Sbjct: 713 TLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAG 772
Query: 413 NVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCN 472
+ L L VNV P+I S P P L R LTC A G P PT+ W
Sbjct: 773 ST--ELRYGLRVNVPPRI--TLPPSLPGPVLVNTPVR--LTCNATGAPSPTLMWL----- 821
Query: 473 HNHSEARCDFCSNNEESFILDADSNMGNRIESI-TQRMAIIEGKNKMASTLVVADSRISG 531
GN + T + + G + TL A + SG
Sbjct: 822 ------------------------KDGNPVSPAGTPGLQVFPGGRVL--TLASARASDSG 855
Query: 532 IYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWIL 591
Y C+A + VG +++ + P+ L E + L C + ++W
Sbjct: 856 RYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWK 915
Query: 592 L-RTVNNRT-MHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQ 649
R + R +H S K + + + + D+G Y C A N E
Sbjct: 916 DGRPLEPRPGVHLSADKALLQVDR------------ADVWDAGHYTCEALNQAGRSE--- 960
Query: 650 KKEITIRDQEAP-YLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE 704
K + AP + LR TV T+L C GVP P+I+W K+ + E
Sbjct: 961 -KHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGE 1015
Score = 71.6 bits (174), Expect = 2e-12
Identities = 141/688 (20%), Positives = 244/688 (35%), Gaps = 130/688 (18%)
Query: 42 IMQAGQTLHLQCRGEAAHKWSLPEMVS---KESERLSITKSACGRNGKQFCSTLTLNTAQ 98
+++ G L C +A LPE K+ + L + + G Q L + AQ
Sbjct: 1852 LVRVGDKAVLSCETDA-----LPEPTVTWYKDGQPLVLAQRTQALRGGQ---RLEIQEAQ 1903
Query: 99 ANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPC 158
+ G YSCK V + + + P E + E + G LV+ C
Sbjct: 1904 VSDKGLYSCKVSNVAGEAVRTFTLTVQV------PPTFE--NPKTETVSQVAGSPLVLTC 1955
Query: 159 RVT---SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFI-ISNATYKEIGLLTCEATVNGH 214
V+ +P +T + P+++ G SR G + +S + G TC A
Sbjct: 1956 DVSGVPAPTVTWLKDRMPVESSAVHGVV----SRGGRLQLSRLQPAQAGTYTCVAE---- 2007
Query: 215 LYKTNYLTHRQTNTIIDVQIS-------TPRPVKLLRGHTLVLNCTAT-TPLNTRVQMTW 266
N + + ++ V ++ R +L G + L+C A P +
Sbjct: 2008 ----NTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKD 2063
Query: 267 SYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSV 326
P ++ +R +D + L + ++ D G YTC V P+ + +
Sbjct: 2064 GSPLGQDMGPHLRFYLDGGS---------LVLKGLRASDAGAYTC-VAHNPAGEDAR--L 2111
Query: 327 HIYDKAFITVKHRKQQVLETVAGKRSYRLSM--KVKAFPSPEVVWLKDGLPATEKSARYL 384
H + + T+ + ++M V+ P V WLKDGLP L
Sbjct: 2112 HTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLL 2171
Query: 385 T-RGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPAL 443
G++L I V DAG +T + + +N T + V P + E F + +
Sbjct: 2172 HGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQV---PPVLEPV--EFQNDVV 2226
Query: 444 YPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIE 503
GS L C A G+P P + W + D + + +E
Sbjct: 2227 VVRGSLVELPCEARGVPLPLVSW------------------------MKDGEPLLSQSLE 2262
Query: 504 SITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNL 563
+G + + DS G Y C+A ++ G R+ + + P H+
Sbjct: 2263 ---------QGPSLQLEAVGAGDS---GTYSCVAVSEAGEARRHFQLTVMEPP---HIED 2307
Query: 564 EKMPTE-----GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSIT 618
PTE G ++L C ++TW K A+T+ + +
Sbjct: 2308 SGQPTELSLTPGAPMELLCDAQGTPQPNITW---------------HKDGQALTRLENNS 2352
Query: 619 LNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVA--ISS 676
++ V +D+G Y C A + E K +R Q P ++ V
Sbjct: 2353 RATRVLRV--RDAGLYTCLAESPAGAIE----KSFRVRVQAPPNIVGPRGPRFVVGLAPG 2406
Query: 677 STTLDCHANGVPEPQITWFKNNHKIQQE 704
L+C P P+ITW ++ +Q++
Sbjct: 2407 QLVLECSVEAEPAPKITWHRDGIVLQED 2434
Score = 71.6 bits (174), Expect = 2e-12
Identities = 84/324 (25%), Positives = 125/324 (38%), Gaps = 37/324 (11%)
Query: 149 TEGRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTC 207
TEG +PC+ SP +T K +GK I S + ++ N ++ G TC
Sbjct: 2859 TEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE-LLVKNLEGQDAGTYTC 2917
Query: 208 EA-TVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTW 266
A G + +LT ++ V + P L G L L C A R+ T
Sbjct: 2918 TAENAVGRARRRVHLTI----LVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT- 2972
Query: 267 SYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSV 326
N R +Q S L + +D G Y C + + V
Sbjct: 2973 -----VNDRPVTEGVSEQDGG------STLQRAAVSREDSGTYVCWAENRVGRTQAVSFV 3021
Query: 327 HIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTR 386
H+ + A + ++E V G S +L V+ P P++ W+KDGLP R+ +
Sbjct: 3022 HVKE-APVLQGEAFSYLVEPVGG--SIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQ 3078
Query: 387 GYSLIIKDVTEEDAGNYTIL----LSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPA 442
SL I +DAG Y L + + + V L + + V+PQ + V S D A
Sbjct: 3079 NGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQ--DMTVRSGDDVA 3136
Query: 443 LYPLGSRQILTCTAYGIPQPTIKW 466
L C A G P PTI+W
Sbjct: 3137 ---------LRCQATGEPTPTIEW 3151
Score = 67.0 bits (162), Expect = 6e-11
Identities = 120/560 (21%), Positives = 207/560 (36%), Gaps = 88/560 (15%)
Query: 160 VTSPNITVTLKKFPLDTLIPDGKRIIWD-SRKGFIISNATYKEIGLLTCEATVNGHLYKT 218
V +PNIT F L+P ++++ + + A + G+ TC+A+
Sbjct: 338 VPTPNITW----FKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKAS-------- 385
Query: 219 NYLTHRQTNTIIDVQI--------STPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPD 270
N + + T +DV + P VK + G + L C A T S+
Sbjct: 386 NAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVA----RGHPSPTLSWHH 441
Query: 271 EKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSV-NTSVHIY 329
E A + + S SVL ++ GLY+C V S P+ ++V SV +
Sbjct: 442 EGLPVA------ESNESRLETDGSVLRLESPGEASSGLYSC-VASSPAGEAVLQYSVEVQ 494
Query: 330 DKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSA-RYLTRGY 388
+ V QV T+ G+ L + P P + WL++G PA E + + ++G
Sbjct: 495 VPPQLLVAEGLGQVT-TIVGQ-PLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGT 552
Query: 389 SLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGS 448
+L I V + +G L + + +N A + V+V + P P+G
Sbjct: 553 TLHIDHVELDHSG----LFACQATNEAGTAGAEVEVSVHGEWA-------PGVLEVPIG- 600
Query: 449 RQILTCTAYGIPQPTIKWFWHPCNHNHSEARCD-----FCSNNEESFILDADSNMGNRIE 503
++ W +H+ A CD + + +++ + G
Sbjct: 601 ----------------QYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPG---- 640
Query: 504 SITQRMAIIEGKNKMASTLVV--ADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHV 561
S+ I + L + D R GIY C A+N G R ++ + PN
Sbjct: 641 SLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPG 700
Query: 562 NLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNL 621
+ K E + L C + DV+W + M ++S L
Sbjct: 701 PVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRV----------L 750
Query: 622 TIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLD 681
I L D+G+Y C A NV E+ + + + L V +++ L
Sbjct: 751 RIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPR---ITLPPSLPGPVLVNTPVRLT 807
Query: 682 CHANGVPEPQITWFKNNHKI 701
C+A G P P + W K+ + +
Sbjct: 808 CNATGAPSPTLMWLKDGNPV 827
Score = 61.2 bits (147), Expect = 3e-09
Identities = 95/447 (21%), Positives = 168/447 (37%), Gaps = 92/447 (20%)
Query: 296 LTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAF-------ITVKHRKQQVLET 346
L I Q +D G YTC V + G + K+ + V I + VK K +V T
Sbjct: 1406 LQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNST 1465
Query: 347 VAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSA-RYLTRGYSLIIKDVTEEDAGNYTI 405
+ L + A P P + W KDG P T S + L G L I+ D+G Y
Sbjct: 1466 LT------LECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLC 1519
Query: 406 LLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQ--------------- 450
+ + ++ + V P +++K V F A + + SR+
Sbjct: 1520 VATNVAGEDDQDFNVLIQV---PPMFQK-VGDFS--AAFEILSREEEARGGVTEYREIVE 1573
Query: 451 ----ILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESIT 506
L C IP P + W+ D + G+ +
Sbjct: 1574 NNPAYLYCDTNAIPPPDLTWYRE-----------------------DQPLSAGDEV---- 1606
Query: 507 QRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVP----NGFHVN 562
++++G + LV A++ +G Y C ASN+VG + + P + +
Sbjct: 1607 ---SVLQGGRVLQIPLVRAEN--AGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELV 1661
Query: 563 LEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLT 622
E + L C ++W+ + +S S ++ + ++ + L
Sbjct: 1662 EEVTVNASSTVSLQCPALGNPVPTISWL------QNGLPFSPSP-RLQVLEDGQV---LQ 1711
Query: 623 IMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLR-NLSDHTVAISSSTTLD 681
+ + D+ +Y C A N E K T+R Q P + +L T ++SS +L
Sbjct: 1712 VSTAEVADAASYMCVAENQAGSAE----KLFTLRVQVPPRIAGLDLEQVTAILNSSVSLP 1767
Query: 682 CHANGVPEPQITWFKNNHKIQQEPELY 708
C + P P++TW+K++ + E++
Sbjct: 1768 CDVHAHPNPEVTWYKDSQALSLGEEVF 1794
Score = 60.1 bits (144), Expect = 7e-09
Identities = 130/612 (21%), Positives = 208/612 (33%), Gaps = 91/612 (14%)
Query: 91 TLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTE 150
+L L A +G YSC V S+ E + + + P +E + P + +T
Sbjct: 2266 SLQLEAVGAGDSGTYSC----VAVSEAGEARRHFQLTVMEP--PHIEDSGQ-PTELSLTP 2318
Query: 151 GRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEA 209
G + + C +P +T K DG+ + ++ GL TC A
Sbjct: 2319 GAPMELLCDAQGTPQPNITWHK--------DGQALTRLENNSRATRVLRVRDAGLYTCLA 2370
Query: 210 TVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYP 269
+ ++ Q I V PR V L LVL C+ ++ TW
Sbjct: 2371 ESPAGAIEKSFRVRVQAPPNI-VGPRGPRFVVGLAPGQLVLECSVEAEPAPKI--TWH-- 2425
Query: 270 DEKNKRASVRRRIDQSNSHANIFYS--VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVH 327
R + + Q ++H L + + D G Y+C R+ SV V
Sbjct: 2426 -----RDGI---VLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVE 2477
Query: 328 IYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARY--LT 385
I+ I R V+ ++ L + P+P V W KD +P +S R+ L
Sbjct: 2478 IHTVPTI----RSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILP 2533
Query: 386 RGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYP 445
G SL I+ V +DAG+Y L S + + + + A++ P
Sbjct: 2534 EG-SLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRV-------LEPPAIAPSPSNLTLT 2585
Query: 446 LGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESI 505
+ +L C A G P+P + W+ + DF R++
Sbjct: 2586 AHTPALLPCEASGSPKPLVVWW-------KDGQKLDF------------------RLQQG 2620
Query: 506 TQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEK 565
R+ A L + S + C+ SN+VG R + P +
Sbjct: 2621 AYRLL-----PSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDF 2675
Query: 566 MPTEGEDLKLSCTVNKFLYRDVTWILL-RTVNNRTMHYSISKQKMAITKEHSITLNLTIM 624
T + L+C V+W + R Y +S L I
Sbjct: 2676 TVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGA-----------LEIG 2724
Query: 625 NVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHA 684
+G Y C ARN + K + + Q +P + S L C A
Sbjct: 2725 QALPIHAGRYTCSARN----SAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEA 2780
Query: 685 NGVPEPQITWFK 696
+G+P P ITW K
Sbjct: 2781 SGIPRPTITWQK 2792
Score = 59.7 bits (143), Expect = 9e-09
Identities = 76/354 (21%), Positives = 129/354 (36%), Gaps = 65/354 (18%)
Query: 355 LSMKVKAFPSPEVVWLKDGLPAT---EKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQ 411
L + P P VVW KDG ++ A L +L++ +D+ + ++S +
Sbjct: 2592 LPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEV 2651
Query: 412 SNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPC 471
+ T V+V P I + + F + P+ +LTC + GIP PT+ W
Sbjct: 2652 GEAHRLYQVT--VHVPPTIADDQ-TDFTVTMMAPV----VLTCHSTGIPAPTVSW----- 2699
Query: 472 NHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISG 531
S+A + G R+ G ++ L + +G
Sbjct: 2700 ----SKAGAQLGARGS-----------GYRVSP--------SGALEIGQALPIH----AG 2732
Query: 532 IYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWIL 591
Y C A N G +++ + P + E++ L C + +TW
Sbjct: 2733 RYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITW-- 2790
Query: 592 LRTVNNRTMHYSISKQKMAITKEHSITL----NLTIMNVSLQDSGTYACRARNVYTGEEI 647
K+ + + S + L I + S +D+G Y C A+N +
Sbjct: 2791 -------------QKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKN--SAGSA 2835
Query: 648 LQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKI 701
+ K + + Q P + L D + S L C A G PEP ITW K+ +
Sbjct: 2836 MGKTRLVV--QVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPV 2887
Score = 58.5 bits (140), Expect = 2e-08
Identities = 112/564 (19%), Positives = 207/564 (36%), Gaps = 106/564 (18%)
Query: 92 LTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEG 151
L + A H G Y+C +++ + ++F++ P V+ +P ++
Sbjct: 2721 LEIGQALPIHAGRYTC------SARNSAGVAHKHVFLTVQASPVVK---PLPSVVRAVAE 2771
Query: 152 RELVIPCRVTS-PNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEA- 209
E+++PC + P T+T +K L+ +++ + I++A+ ++ G C A
Sbjct: 2772 EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQ--LRIAHASPEDAGNYLCIAK 2829
Query: 210 -TVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSY 268
+ + KT + Q +I+ + + G L C A + +TW
Sbjct: 2830 NSAGSAMGKTRLVV--QVPPVIENGLPD---LSTTEGSHAFLPCKARG--SPEPNITWDK 2882
Query: 269 PDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSV 326
+ A + I S L + ++ +D G YTC + G + + V+ ++
Sbjct: 2883 DGQPVSGAEGKFTIQPSGE--------LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTI 2934
Query: 327 HIYDKAFITVKHRKQQVLETVAGKRSYRLSMKV------KAFPSPEVVWLKDGLPATEKS 380
+ V T+ G RS RL ++ + P+P + W + P TE
Sbjct: 2935 LVLP------------VFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV 2982
Query: 381 ARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVK--PQIYEKAVSSF 438
+ G +L V+ ED+G Y N A V+VK P + +A S
Sbjct: 2983 SEQ-DGGSTLQRAAVSREDSGTYVCWAE----NRVGRTQAVSFVHVKEAPVLQGEAFSYL 3037
Query: 439 PDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNM 498
+P +G L C G P P I W I D
Sbjct: 3038 VEP----VGGSIQLDCVVRGDPVPDIHW------------------------IKDGLPLR 3069
Query: 499 GNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNG 558
G+ + Q ++ T+ + +G Y C+A N++G + + + P
Sbjct: 3070 GSHLRHQLQNGSL---------TIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPV- 3119
Query: 559 FHVNLEKMPTE-GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSI 617
F V + M G+D+ L C + W+ + + +++ + S+
Sbjct: 3120 FQVEPQDMTVRSGDDVALRCQATGEPTPTIEWL-------QAGQPLRASRRLRTLPDGSL 3172
Query: 618 TLNLTIMNVSLQDSGTYACRARNV 641
L NV D+GTY C A N+
Sbjct: 3173 WLE----NVETGDAGTYDCVAHNL 3192
Score = 57.8 bits (138), Expect = 4e-08
Identities = 75/347 (21%), Positives = 121/347 (34%), Gaps = 65/347 (18%)
Query: 363 PSPEVVWLKDGLPATEKSARY-LTRGYSLIIKDVTEEDAGNYTILL----SIKQSNVFKN 417
P+P V W K G + + Y ++ +L I AG YT + +VF
Sbjct: 2693 PAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLT 2752
Query: 418 LTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSE 477
+ A+ +V P + +AV+ +L C A GIP+PTI W
Sbjct: 2753 VQASPVVKPLPSVV-RAVAE----------EEVLLPCEASGIPRPTITW----------- 2790
Query: 478 ARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIA 537
G + + + G+ ++A A +G Y+CIA
Sbjct: 2791 ------------------QKEGLNVATGVSTQVLPGGQLRIAH----ASPEDAGNYLCIA 2828
Query: 538 SNKVGTVGRNISFYITDVPNGFHVNLEKMPT-EGEDLKLSCTVNKFLYRDVTWILLRTVN 596
N G+ + VP L + T EG L C ++TW +
Sbjct: 2829 KNSAGSAMGKTRL-VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITW------D 2881
Query: 597 NRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIR 656
S ++ K I L + N+ QD+GTY C A N ++ + +
Sbjct: 2882 KDGQPVSGAEGKFTIQPSGE----LLVKNLEGQDAGTYTCTAENAVG----RARRRVHLT 2933
Query: 657 DQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQ 703
P D ++ + L C A G P P+I W N+ + +
Sbjct: 2934 ILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTE 2980
Score = 55.5 bits (132), Expect = 2e-07
Identities = 140/670 (20%), Positives = 237/670 (35%), Gaps = 132/670 (19%)
Query: 77 TKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFV 136
TK R G+Q L L AQ++ G Y+CK + +K T +Y+ P +
Sbjct: 356 TKVVYTRGGRQ----LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYV------PPTI 405
Query: 137 EMYSEIPEIIHMTEGRELVIPCRVTS-PNITVTLKKFPLDTLIPDGKRIIWDSRKGFIIS 195
E P ++ GR + + C P+ T++ L + R+ D +
Sbjct: 406 EGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSV-LRLE 464
Query: 196 NATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTAT 255
+ GL +C A+ Y Q + V + V + G L L C A+
Sbjct: 465 SPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQ-VTTIVGQPLELPCQAS 523
Query: 256 -TPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRV- 313
+P+ T + P E+ V + + L ID ++ GL+ C+
Sbjct: 524 GSPVPTIQWLQNGRPAEELAGVQVASQ-----------GTTLHIDHVELDHSGLFACQAT 572
Query: 314 -RSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK------------ 360
+G + V SVH VLE G+ +
Sbjct: 573 NEAGTAGAEVEVSVH---------GEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRG 623
Query: 361 --AFPSPEVV--WLKDGLPATEKSARYLTRGYSLI----IKDVTEEDAGNYTILLSIKQS 412
A P P +V W G E + + YSL I+ V D G YT +
Sbjct: 624 WGAHPKPPLVEGWCSPGSLWGEPTG--IPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAG 681
Query: 413 NVFKNLTATLIV--NVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHP 470
+ + ++V N++P KAV + L C A G+P P + WF
Sbjct: 682 ESKREVALKVLVPPNIEPGPVNKAVLE---------NASVTLECLASGVPPPDVSWF--- 729
Query: 471 CNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS 530
H S MG + S+ R+ IE A +
Sbjct: 730 --KGHQPV----------------SSWMGVTV-SVDGRVLRIEQ----------AQLSDA 760
Query: 531 GIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDL----------KLSCTVN 580
G Y C+ASN G+ T++ G VN+ T L +L+C
Sbjct: 761 GSYRCVASNVAGS---------TELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNAT 811
Query: 581 KFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
+ W L+ N + + Q + LT+ + DSG Y+C A +
Sbjct: 812 GAPSPTLMW--LKDGNPVSPAGTPGLQVFPGGRV------LTLASARASDSGRYSCVAVS 863
Query: 641 VYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHK 700
GE+ ++++ ++ P +L + +V + S L+C ++ +P P ++W+K+
Sbjct: 864 A-VGED---RQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRP 919
Query: 701 IQQEPELYTS 710
++ P ++ S
Sbjct: 920 LEPRPGVHLS 929
Score = 54.7 bits (130), Expect = 3e-07
Identities = 87/423 (20%), Positives = 152/423 (35%), Gaps = 65/423 (15%)
Query: 295 VLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRS 352
VLT+ + D G Y+C S G + V VH+ +++ +V S
Sbjct: 843 VLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSIL------GEELNVSVVANES 896
Query: 353 YRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEE-DAGNYTILLSIKQ 411
L + A P P + W KDG P + +L+ +L+ D + DAG+YT +
Sbjct: 897 VALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQA 956
Query: 412 SNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPC 471
K+ + V + E + + G L+C G+P P I W
Sbjct: 957 GRSEKHYNLNVWVAPVFPLRESHTLTVRE------GHPTSLSCECRGVPFPKISW----- 1005
Query: 472 NHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISG 531
++ L + + ++ + + + G+ ++A G
Sbjct: 1006 --------------RKDGQPLPGEGAGLQHVSAVGRLLYL--GQAQLAQ---------EG 1040
Query: 532 IYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLK-----LSCTVNKFLYRD 586
Y C SN VG +++ + P + PT+ ++ L C
Sbjct: 1041 TYTCECSNVVGNSSQDLQLEVHVPPQ--IAGPREPPTQVSVVQDGVATLECNATGKPPPT 1098
Query: 587 VTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEE 646
VTW + + Q ++ E + +G Y+C A N+ E
Sbjct: 1099 VTWERDGQPVGAELGLQLQNQGQSLHVERA----------QAAHTGRYSCVAENLAGRAE 1148
Query: 647 ILQKKEITIR-DQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEP 705
+K E+++ E L L++ T A+ S TL C A G+P P I WF+ +
Sbjct: 1149 --RKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGE 1206
Query: 706 ELY 708
+ Y
Sbjct: 1207 DTY 1209
Score = 53.9 bits (128), Expect = 5e-07
Identities = 88/425 (20%), Positives = 152/425 (35%), Gaps = 67/425 (15%)
Query: 288 HANIFYSVLTIDKMQNKDKGLYTCRV--RSGPSFKSVNTSVHIYDKAFITVKHRKQQVLE 345
H + ++L +D+ D G YTC ++G S K N +V + + H
Sbjct: 927 HLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTL----- 981
Query: 346 TVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSA---RYLTRGYSLIIKDVTEEDAGN 402
TV LS + + P P++ W KDG P + A G L + G
Sbjct: 982 TVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGT 1041
Query: 403 YTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQP 462
YT S N ++L L V+V PQI P L C A G P P
Sbjct: 1042 YTCECSNVVGNSSQDL--QLEVHVPPQI--AGPREPPTQVSVVQDGVATLECNATGKPPP 1097
Query: 463 TIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTL 522
T+ W E + +G ++++ Q + +
Sbjct: 1098 TVTW---------------------ERDGQPVGAELGLQLQNQGQSLHVER--------- 1127
Query: 523 VVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKF 582
A + +G Y C+A N G R F +++ P DL +
Sbjct: 1128 --AQAAHTGRYSCVAENLAGRAERK-----------FELSVLVPPELIGDLDPLTNITAA 1174
Query: 583 LYRDVTWIL-LRTVNNRTMHYSISKQKMAITKEHSITLN---LTIMNVSLQDSGTYACRA 638
L+ +T + + + + ++ ++ ++ + L + QDSG Y+C A
Sbjct: 1175 LHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLA 1234
Query: 639 RNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTT--LDCHANGVPEPQITWFK 696
N GE ++ ++ P + + + + T L C+ G P+P++TWFK
Sbjct: 1235 SN-EAGE---ARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFK 1290
Query: 697 NNHKI 701
+ +
Sbjct: 1291 DGRPL 1295
Score = 53.9 bits (128), Expect = 5e-07
Identities = 123/614 (20%), Positives = 214/614 (34%), Gaps = 86/614 (14%)
Query: 91 TLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTE 150
+L L +A+ G Y+C + E A ++ P ++ ++ +
Sbjct: 2083 SLVLKGLRASDAGAYTC------VAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRP 2136
Query: 151 GRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEA 209
G + + C V SP I V+ K L + + ++ S IS + G+ TC A
Sbjct: 2137 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQ-RTLLHGSGHTLRISKVQLADAGIFTCVA 2195
Query: 210 TVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTAT-TPLNTRVQMTWSY 268
+ N+ Q +++ + V ++RG + L C A PL ++W
Sbjct: 2196 ASPAGVADRNFTLQVQVPPVLE-PVEFQNDVVVVRGSLVELPCEARGVPLPL---VSWM- 2250
Query: 269 PDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHI 328
K+ + + ++Q S L ++ + D G Y+C S + + +
Sbjct: 2251 ---KDGEPLLSQSLEQGPS--------LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTV 2299
Query: 329 YDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGY 388
+ I + ++ T L + P P + W KDG T
Sbjct: 2300 MEPPHIEDSGQPTELSLTPGAPME--LLCDAQGTPQPNITWHKDGQALTR------LENN 2351
Query: 389 SLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGS 448
S + + DAG YT L + K+ V P I F L P
Sbjct: 2352 SRATRVLRVRDAGLYTCLAESPAGAIEKSFRVR--VQAPPNIVGPRGPRFV-VGLAP--G 2406
Query: 449 RQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQR 508
+ +L C+ P P I W + + +L D++ +R
Sbjct: 2407 QLVLECSVEAEPAPKITW-------------------HRDGIVLQEDAHT-----QFPER 2442
Query: 509 MAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPT 568
G+ L ADS G Y C A N G+ I VP +
Sbjct: 2443 -----GRFLQLQALSTADS---GDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVS 2494
Query: 569 EGEDLKLSCTVNKFLYRDVTWILLRT-VNNRTMHYSISKQKMAITKEHSITLNLTIMNVS 627
+ L C + V+W R ++ R+ + I + +L I V
Sbjct: 2495 VNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEG-----------SLRIQPVL 2543
Query: 628 LQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGV 687
QD+G Y C A N + ++ +R E P + + S+ T+ + L C A+G
Sbjct: 2544 AQDAGHYLCLASNSAGSD----RQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGS 2599
Query: 688 PEPQITWFKNNHKI 701
P+P + W+K+ K+
Sbjct: 2600 PKPLVVWWKDGQKL 2613
Score = 52.4 bits (124), Expect = 2e-06
Identities = 93/378 (24%), Positives = 139/378 (36%), Gaps = 63/378 (16%)
Query: 295 VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYR 354
VL I D+G Y C S ++ + + ++ I + +V V +
Sbjct: 273 VLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEV--AVMEDHLVQ 330
Query: 355 LSMKVKAFPSPEVVWLKDG-LPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSN 413
L + + P+P + W KDG L T Y G L + DAG YT K SN
Sbjct: 331 LLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYT----CKASN 386
Query: 414 VF--KNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPC 471
L V V P I + P G L C A G P PT+ W
Sbjct: 387 AVGAAEKATRLDVYVPPTI--EGAGGRPYVVKAVAGRPVALECVARGHPSPTLSW----- 439
Query: 472 NHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISG 531
H E +NE L+ D ++ R+ES SG
Sbjct: 440 ---HHEG-LPVAESNESR--LETDGSV-LRLES--------------------PGEASSG 472
Query: 532 IYICIASNKVGTVGRNISFYITDVPNGFHV--NLEKMPT-EGEDLKLSCTVNKFLYRDVT 588
+Y C+AS+ G S + VP V L ++ T G+ L+L C + +
Sbjct: 473 LYSCVASSPAGEAVLQYSVEV-QVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQ 531
Query: 589 WILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNV--YTGEE 646
W+ N R +++A + S L I +V L SG +AC+A N G E
Sbjct: 532 WL----QNGR------PAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAE 581
Query: 647 ILQKKEITIRDQEAPYLL 664
+ E+++ + AP +L
Sbjct: 582 V----EVSVHGEWAPGVL 595
Score = 40.0 bits (92), Expect = 0.008
Identities = 45/221 (20%), Positives = 85/221 (38%), Gaps = 39/221 (17%)
Query: 531 GIYICIASNKVGTVGRNISFYITDVPN--GFHVNLEKMPTEGEDLKLSCTVNKFLYRDVT 588
G Y C+A + G R+ + P G + E E ++L C ++T
Sbjct: 285 GRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNIT 344
Query: 589 WI----LLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTG 644
W LL T + + Y+ +++ + + S D+G Y C+A N
Sbjct: 345 WFKDGALLPT--STKVVYTRGGRQLQLGRAQS------------SDAGVYTCKASNAVGA 390
Query: 645 EEILQKKEITIRDQ-----EAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWF---- 695
E + ++ + PY+++ ++ VA L+C A G P P ++W
Sbjct: 391 AEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVA------LECVARGHPSPTLSWHHEGL 444
Query: 696 ----KNNHKIQQEPELYTSTSPSSSSSSPLSSSSSSSSSSS 732
N +++ + + SP +SS S +SS + +
Sbjct: 445 PVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEA 485
Score = 38.1 bits (87), Expect = 0.029
Identities = 25/80 (31%), Positives = 37/80 (46%), Gaps = 6/80 (7%)
Query: 620 NLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVA--ISSS 677
+L + +VS DSG Y C+A N K + + P + + V+ S
Sbjct: 58 SLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYV----PPSIREDGRKANVSGMAGQS 113
Query: 678 TTLDCHANGVPEPQITWFKN 697
TL+C ANG P P+I W K+
Sbjct: 114 LTLECDANGFPVPEIVWLKD 133
Score = 35.0 bits (79), Expect = 0.25
Identities = 24/86 (27%), Positives = 41/86 (47%), Gaps = 9/86 (10%)
Query: 509 MAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVP----NGFHVNLE 564
+A++E + +++ ADS G Y C A+N+VG+ R + P +G N+
Sbjct: 51 VAVLEEGSLFLASVSPADS---GDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVS 107
Query: 565 KMPTEGEDLKLSCTVNKFLYRDVTWI 590
M G+ L L C N F ++ W+
Sbjct: 108 GM--AGQSLTLECDANGFPVPEIVWL 131
Score = 34.3 bits (77), Expect = 0.42
Identities = 25/79 (31%), Positives = 35/79 (44%), Gaps = 6/79 (7%)
Query: 621 LTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSS--T 678
L I + D G Y C A + G+ Q ++ +R P + + VA+
Sbjct: 274 LRITGSHVGDEGRYQCVAFSP-AGQ---QARDFQLRVHAPPTIWGSNETGEVAVMEDHLV 329
Query: 679 TLDCHANGVPEPQITWFKN 697
L C A GVP P ITWFK+
Sbjct: 330 QLLCEARGVPTPNITWFKD 348
Score = 33.9 bits (76), Expect = 0.55
Identities = 23/68 (33%), Positives = 30/68 (44%), Gaps = 2/68 (2%)
Query: 305 DKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPS 364
D G Y C+ + S + +Y I RK V +AG+ S L FP
Sbjct: 68 DSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANV-SGMAGQ-SLTLECDANGFPV 125
Query: 365 PEVVWLKD 372
PE+VWLKD
Sbjct: 126 PEIVWLKD 133
Score = 32.7 bits (73), Expect = 1.2
Identities = 31/109 (28%), Positives = 44/109 (40%), Gaps = 13/109 (11%)
Query: 363 PSPEVVWLKDGLPATEK-----SARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKN 417
P P+V W K P++E L G SL + V+ D+G+Y + + + +
Sbjct: 30 PKPQVTWRKG--PSSEPLHGQPGVAVLEEG-SLFLASVSPADSGDYECQATNEVGSTSRR 86
Query: 418 LTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKW 466
A L+V V P I E + G L C A G P P I W
Sbjct: 87 --AKLVVYVPPSIREDGRKANVSGMA---GQSLTLECDANGFPVPEIVW 130
Score = 30.8 bits (68), Expect = 4.7
Identities = 34/137 (24%), Positives = 54/137 (39%), Gaps = 12/137 (8%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
LTI + + D G Y C + + + V+ + TV L
Sbjct: 3082 LTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDM----TVRSGDDVAL 3137
Query: 356 SMKVKAFPSPEVVWLKDGLP-ATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNV 414
+ P+P + WL+ G P + R L G SL +++V DAG Y + N+
Sbjct: 3138 RCQATGEPTPTIEWLQAGQPLRASRRLRTLPDG-SLWLENVETGDAGTYDCV----AHNL 3192
Query: 415 FKNLTAT--LIVNVKPQ 429
+ TA L+V +PQ
Sbjct: 3193 LGSATARAFLVVRGEPQ 3209
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 85.5 bits (210), Expect = 2e-16
Identities = 100/421 (23%), Positives = 164/421 (38%), Gaps = 67/421 (15%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
L + + Q+ D G+YTC+ + T + +Y I + V++ VAG R L
Sbjct: 1558 LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAG-RPVAL 1616
Query: 356 SMKVKAFPSPEVVWLKDGLPATEKS-ARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNV 414
+ PSP + W +GLP E + +R T G L ++ E +G Y+ + S
Sbjct: 1617 ECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEA 1676
Query: 415 FKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHN 474
L ++ V V PQ+ V+ +G L C A G P PTI+W +
Sbjct: 1677 V--LQYSVEVQVPPQL---LVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQN----- 1726
Query: 475 HSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRI--SGI 532
G E + +G +TL + + SG+
Sbjct: 1727 ------------------------GRPAEELAGVQVASQG-----TTLHIDHVELDHSGL 1757
Query: 533 YICIASNKVGTVGRNISFY--------ITDVPNG-FHVNLEKMPTEGEDLKLSCTVNKFL 583
+ C A+N+ GT G + + +VP G +H E + +
Sbjct: 1758 FACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXE------HHSSFPAACDPPV 1811
Query: 584 YRDVTW---ILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
+R W V S+ + I +S+ L I V L+D G Y C A N
Sbjct: 1812 HRG--WGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATN 1869
Query: 641 VYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHK 700
+ GE K+E+ ++ P + + V ++S TL+C A+GVP P ++WFK +
Sbjct: 1870 L-AGE---SKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQP 1925
Query: 701 I 701
+
Sbjct: 1926 V 1926
Score = 84.3 bits (207), Expect = 4e-16
Identities = 99/397 (24%), Positives = 146/397 (36%), Gaps = 70/397 (17%)
Query: 307 GLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRK-----QQVLETVAGKRSYRLSMKVKA 361
G YTC R N++ + F+TV+ V+ VA + L +
Sbjct: 3923 GRYTCSAR--------NSAGVAHKHVFLTVQASPVVKPLPSVVRAVA-EEEVLLPCEASG 3973
Query: 362 FPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTAT 421
P P + W K+GL + + G L I + EDAGNY L I +++ + T
Sbjct: 3974 IPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNY---LCIAKNSAGSAMGKT 4030
Query: 422 LIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCD 481
+V P + E + PD + GS L C A G P+P I W
Sbjct: 4031 RLVVQVPPVIENGL---PDLSTTE-GSHAFLPCKARGSPEPNITW--------------- 4071
Query: 482 FCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKV 541
D D G + + I + L D+ G Y C A N V
Sbjct: 4072 -----------DKD---GQPVSGAEGKFTIQPSGELLVKNLEGQDA---GTYTCTAENAV 4114
Query: 542 GTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMH 601
G R + I +P + ++ G+ L L C + W TVN+R +
Sbjct: 4115 GRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGW----TVNDRPVT 4170
Query: 602 YSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAP 661
+S+Q T + + VS +DSGTY C A N + + + +EAP
Sbjct: 4171 EGVSEQDGGSTLQRAA--------VSREDSGTYVCWAENRVGRTQAVS----FVHVKEAP 4218
Query: 662 YLLRNLSDHTV-AISSSTTLDCHANGVPEPQITWFKN 697
L + V + S LDC G P P I W K+
Sbjct: 4219 VLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKD 4255
Score = 81.3 bits (199), Expect = 3e-15
Identities = 115/453 (25%), Positives = 164/453 (36%), Gaps = 83/453 (18%)
Query: 248 LVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKG 307
L+++C+ + L R+Q+ R R +S N + +L K + +G
Sbjct: 444 LLVSCSVHSALPFRLQLR-----RGEARLGEERHFQESG---NSSWEILRASKAE---EG 492
Query: 308 LYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLE----TVAGKRSYRLSMKVKAFP 363
Y C S KA I V Q++ TV+ + LS +V
Sbjct: 493 TYECTAVSRAGTGRA--------KAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEA 544
Query: 364 SPEVVWLKDG--LPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTAT 421
+ W++D LPA+ L SL I + D G Y + S +N +
Sbjct: 545 PYNLTWVRDWRVLPASTGRVAQLA-DLSLEISGIIPTDGGRYQCVAS--NANGVTRASVW 601
Query: 422 LIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCD 481
L+V PQ VS + G ++C+A G P P I W
Sbjct: 602 LLVREAPQ-----VSIHTSSQHFSQGVEVKVSCSASGYPTPHISW--------------- 641
Query: 482 FCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKV 541
+ ES L DS RI Q II+G +G Y C A+N+V
Sbjct: 642 ----SRESQALQEDS----RIHVDAQGTLIIQG----------VAPEDAGNYSCQATNEV 683
Query: 542 GTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMH 601
GT ++ Y TD P+ VN + GE+ L C + V W
Sbjct: 684 GTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR---------- 733
Query: 602 YSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAP 661
+M + E S + L I +D+GTY CRA N E EI + AP
Sbjct: 734 ---GGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVN----ELGDASAEIQLAVGHAP 786
Query: 662 YLLRNLSDHTVAISSSTTLDCHANGVPEPQITW 694
L D TV + S L C A G P P +TW
Sbjct: 787 QLTELPRDVTVELGRSALLACRATGRPPPTVTW 819
Score = 80.9 bits (198), Expect = 4e-15
Identities = 136/665 (20%), Positives = 247/665 (37%), Gaps = 133/665 (20%)
Query: 91 TLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTE 150
+L + AQA HTG YSC +A + + E + + + + E+ ++ + ++T
Sbjct: 2313 SLHVERAQAAHTGRYSC--VAENLAGRAERKFELSVLVPP------ELIGDLDPLTNITA 2364
Query: 151 GRE--LVIPCR---VTSPNITVTLKKFPL----DTLIPDGKRIIWDSRKGFIISNATYKE 201
L + C + P I + P+ DT + G ++ ++ ++
Sbjct: 2365 ALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLK-------MTQTQEQD 2417
Query: 202 IGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTR 261
GL +C A+ + N+ I+ + +K+L G T L C T + +
Sbjct: 2418 SGLYSCLASNEAGEARRNFSVEVLVPPSIENE-DLEEVIKVLDGQTAHLMCNVTG--HPQ 2474
Query: 262 VQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS--GPSF 319
++TW R H + +L + + G Y+C + G
Sbjct: 2475 PKLTWFKDGRPLARGDAH--------HISPDGVLLQVLQANLSSAGHYSCIAANAVGEKT 2526
Query: 320 KSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLP-ATE 378
K SV + + + + TV L + AFPSP + W+KDG P
Sbjct: 2527 KHFQLSVLLAPTILGGAEDSADEEV-TVTVNNPISLICEALAFPSPNITWMKDGAPFEAS 2585
Query: 379 KSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSF 438
++ + L + L I + +EDAG YT +++ + KN +++ P I +
Sbjct: 2586 RNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLI--PPSISK------ 2637
Query: 439 PDPALYPLGSRQILT---------CTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEES 489
D L +G +++ T C ++ +P PTI+W+
Sbjct: 2638 -DDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWY---------------------- 2674
Query: 490 FILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNIS 549
G + ++ + EG+ V+DS G Y+C+A+N G ++ +
Sbjct: 2675 -------KDGQPVTPSSRLQVLGEGRLLQIQPTQVSDS---GRYLCVATNVAGEDDQDFN 2724
Query: 550 FYITDVP-----NGFHVNLEKMPTEGE---------------DLKLSCTVNKFLYRDVTW 589
I P F E + E E L C N D+TW
Sbjct: 2725 VLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTW 2784
Query: 590 ILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSL---QDSGTYACRARNVYTGEE 646
Q ++ E S+ ++ + L +++G Y+C+A N GE+
Sbjct: 2785 YR-------------EDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNE-VGED 2830
Query: 647 ILQKKEITIRDQEAPYLLRN----LSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQ 702
L + + + P +L + + + TV SS+ +L C A G P P I+W +N
Sbjct: 2831 WLHYELLVLTP---PVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFS 2887
Query: 703 QEPEL 707
P L
Sbjct: 2888 PSPRL 2892
Score = 80.5 bits (197), Expect = 5e-15
Identities = 94/409 (22%), Positives = 151/409 (36%), Gaps = 75/409 (18%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
L I K+Q D G++TC S N ++ + + + V+ V L
Sbjct: 3369 LRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVV--VVRGSLVEL 3426
Query: 356 SMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVF 415
+ + P P V W+KDG P +S L +G SL ++ V D+G Y+ + +
Sbjct: 3427 PCEARGVPLPLVSWMKDGEPLLSQS---LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEAR 3483
Query: 416 KNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNH 475
++ T++ P I + S P G+ L C A G PQP I W H
Sbjct: 3484 RHFQLTVME--PPHIED---SGQPTELSLTPGAPMELLCDAQGTPQPNITW--------H 3530
Query: 476 SEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYIC 535
+ Q + +E ++ L V D+ G+Y C
Sbjct: 3531 KDG----------------------------QALTRLENNSRATRVLRVRDA---GLYTC 3559
Query: 536 IASNKVGTVGRNISFYITDVPN-------GFHVNLEKMPTEGEDLKLSCTVNKFLYRDVT 588
+A + G + ++ + PN F V L L L C+V +T
Sbjct: 3560 LAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAP-----GQLVLECSVEAEPAPKIT 3614
Query: 589 WILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEIL 648
W I Q+ A T+ L + +S DSG Y+C ARN +
Sbjct: 3615 W----------HRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVA 3664
Query: 649 QKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKN 697
+ EI P + V+++ + L C A+GVP P ++W K+
Sbjct: 3665 FRVEI----HTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKD 3709
Score = 80.1 bits (196), Expect = 7e-15
Identities = 86/371 (23%), Positives = 134/371 (36%), Gaps = 65/371 (17%)
Query: 344 LETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTR-GYSLIIKDVTEEDAGN 402
L T G ++ L K + P P + W KDG P + ++ + L++K++ +DAG
Sbjct: 4047 LSTTEGSHAF-LPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGT 4105
Query: 403 YTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQP 462
YT + + T++V ++ P LG R L C A G P P
Sbjct: 4106 YTCTAENAVGRARRRVHLTILVL-------PVFTTLPGDRSLRLGDRLWLRCAARGSPTP 4158
Query: 463 TIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTL 522
I W + +R +T+ ++ +G + +
Sbjct: 4159 RIGW------------------------------TVNDR--PVTEGVSEQDGGSTLQRAA 4186
Query: 523 VVADSRISGIYICIASNKVGTVGRNISFYITDVP----NGFHVNLEKMPTEGEDLKLSCT 578
V + SG Y+C A N+VG ++ + P F +E + G ++L C
Sbjct: 4187 VSRED--SGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPV---GGSIQLDCV 4241
Query: 579 VNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRA 638
V D+ WI + R H Q + LTI D+G Y C A
Sbjct: 4242 VRGDPVPDIHWIK-DGLPLRGSHLRHQLQNGS----------LTIHRTERDDAGRYQCLA 4290
Query: 639 RNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNN 698
N E + KK + + Q AP D TV L C A G P P I W +
Sbjct: 4291 EN----EMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAG 4346
Query: 699 HKIQQEPELYT 709
++ L T
Sbjct: 4347 QPLRASRRLRT 4357
Score = 77.4 bits (189), Expect = 4e-14
Identities = 99/426 (23%), Positives = 170/426 (39%), Gaps = 69/426 (16%)
Query: 296 LTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSY 353
L I + Q DKGLY+C+V + G + ++ +V + T ++ K + + VAG
Sbjct: 3088 LEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPP----TFENPKTETVSQVAGSPLV 3143
Query: 354 RLSMKVKAFPSPEVVWLKDGLPATEKSAR-YLTRGYSLIIKDVTEEDAGNYTILLSIKQS 412
L+ V P+P V WLKD +P + ++RG L + + AG YT + Q+
Sbjct: 3144 -LTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQA 3202
Query: 413 NVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQI-LTCTAYGIPQPTIKWFWHPC 471
K+ ++V P+I V+ + L +++ L C A G P P + W
Sbjct: 3203 EARKDFVVAVLV--APRIRSSGVAR----EHHVLEGQEVRLDCEADGQPPPDVAWL---- 3252
Query: 472 NHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISG 531
++ L D MG + ++G + + L +D+ G
Sbjct: 3253 ---------------KDGSPLGQD--MGPHLRFY------LDGGSLVLKGLRASDA---G 3286
Query: 532 IYICIASNKVGTVGRNISFYITDVPN---GFHVNLEKMPTEGEDLKLSCTVNKFLYRDVT 588
Y C+A N G R + + P G + + GE + + C V V+
Sbjct: 3287 AYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVS 3346
Query: 589 WILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEIL 648
W+ + +S++ + H+ L I V L D+G + C V +
Sbjct: 3347 WL------KDGLPLPLSQRTLLHGSGHT----LRISKVQLADAGIFTC----VAASPAGV 3392
Query: 649 QKKEITIRDQEAPYL--LRNLSDHTVAISSSTTLDCHANGVPEPQITWFKN-----NHKI 701
+ T++ Q P L + +D V S L C A GVP P ++W K+ + +
Sbjct: 3393 ADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSL 3452
Query: 702 QQEPEL 707
+Q P L
Sbjct: 3453 EQGPSL 3458
Score = 77.0 bits (188), Expect = 6e-14
Identities = 80/360 (22%), Positives = 138/360 (38%), Gaps = 59/360 (16%)
Query: 352 SYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRG-YSLIIKDVTEEDAGNYTILLSIK 410
S L V A P+PEV W KD + +L G ++L + D+G YT
Sbjct: 2954 SVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNA 3013
Query: 411 QSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHP 470
K + +++V P + +A D L +G + +L+C +P+PT+ W+
Sbjct: 3014 AGRDQKLVQLSVLV---PPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWY--- 3067
Query: 471 CNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS 530
+ + +L QR + G + L + ++++S
Sbjct: 3068 --------------KDGQPLVL-------------AQRTQALRGGQR----LEIQEAQVS 3096
Query: 531 --GIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMP-TEGEDLKLSCTVNKFLYRDV 587
G+Y C SN G R + + P + E + G L L+C V+ V
Sbjct: 3097 DKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTV 3156
Query: 588 TWILLRT-VNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEE 646
TW+ R V + +H +S+ L + + +GTY C A N +
Sbjct: 3157 TWLKDRMPVESSAVHGVVSRGG-----------RLQLSRLQPAQAGTYTCVAENT----Q 3201
Query: 647 ILQKKEITIRDQEAPYLLRN--LSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE 704
+K+ + AP + + +H V LDC A+G P P + W K+ + Q+
Sbjct: 3202 AEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQD 3261
Score = 77.0 bits (188), Expect = 6e-14
Identities = 140/654 (21%), Positives = 248/654 (37%), Gaps = 111/654 (16%)
Query: 69 KESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFI 128
K+S+ LS+ + G TL L A+ + +G Y+C+ L +K + ++ +
Sbjct: 2973 KDSQALSLGEEVFLLPGTH---TLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLV-- 3027
Query: 129 SDTGRPFVEMYSEIPE-IIHMTEGRELVIPCRVTS-PNITVTLKKFPLDTLIPDGKRIIW 186
P P+ + + G + V+ C + P TVT K DG+ ++
Sbjct: 3028 ----PPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYK--------DGQPLVL 3075
Query: 187 DSRKGFI-------ISNATYKEIGLLTCEAT-VNGHLYKTNYLTHRQTNTIIDVQISTPR 238
R + I A + GL +C+ + V G +T LT + T + + T
Sbjct: 3076 AQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTET-- 3133
Query: 239 PVKLLRGHTLVLNCTAT-TPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLT 297
V + G LVL C + P T +TW + ++V + + L
Sbjct: 3134 -VSQVAGSPLVLTCDVSGVPAPT---VTWLKDRMPVESSAVHGVVSRGGR--------LQ 3181
Query: 298 IDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
+ ++Q G YTC + + K +V + + + R+ VLE + RL
Sbjct: 3182 LSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEG----QEVRL 3237
Query: 356 SMKVKAFPSPEVVWLKDGLPATEKSA---RYLTRGYSLIIKDVTEEDAGNYTILLSIKQS 412
+ P P+V WLKDG P + R+ G SL++K + DAG YT +
Sbjct: 3238 DCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAG 3297
Query: 413 NVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCN 472
+ T ++ V P I + A S + G + C G P + W
Sbjct: 3298 EDARLHTVNVL--VPPTIKQGADGS--GTLVSRPGELVTMVCPVRGSPPIHVSWL----- 3348
Query: 473 HNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAII-EGKNKMASTLVVADSRISG 531
++ L ++QR + G S + +AD +G
Sbjct: 3349 --------------KDGLPL-----------PLSQRTLLHGSGHTLRISKVQLAD---AG 3380
Query: 532 IYICIASNKVGTVGRNISFYITDVPNGFHVNLEK--MPTEGEDLKLSCTVNKFLYRDVTW 589
I+ C+A++ G RN + + P V + + G ++L C V+W
Sbjct: 3381 IFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSW 3440
Query: 590 ILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQ 649
+ + ++ + E +L L V DSGTY+C A V E +
Sbjct: 3441 M------------KDGEPLLSQSLEQGPSLQLEA--VGAGDSGTYSCVA--VSEAGEARR 3484
Query: 650 KKEITIRDQEAPYLLRNLSDHTVAISSSTTLD--CHANGVPEPQITWFKNNHKI 701
++T+ E P++ + ++++ ++ C A G P+P ITW K+ +
Sbjct: 3485 HFQLTV--MEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL 3536
Score = 76.6 bits (187), Expect = 7e-14
Identities = 97/426 (22%), Positives = 160/426 (37%), Gaps = 75/426 (17%)
Query: 288 HANIFYSVLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLE 345
H + +L + + Q +G YTC + G S + + VH+ + R+
Sbjct: 2212 HVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQI---AGPREPPTQV 2268
Query: 346 TVAGKRSYRLSMKVKAFPSPEVVWLKDGLPA-TEKSARYLTRGYSLIIKDVTEEDAGNYT 404
+V L P P V W +DG P E + +G SL ++ G Y+
Sbjct: 2269 SVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYS 2328
Query: 405 ILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALY---PLGSRQILTCTAYGIPQ 461
+ + +++V P++ DP L S L C A GIP
Sbjct: 2329 CVAENLAGRAERKFELSVLV--PPELIGDL-----DPLTNITAALHSPLTLLCEAMGIPP 2381
Query: 462 PTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMAST 521
P I+WF + S E++++L G + +TQ
Sbjct: 2382 PAIRWFRGE----------EPVSPGEDTYLL-----AGGWMLKMTQ-------------- 2412
Query: 522 LVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKM--PTEGEDLKLSCTV 579
+ SG+Y C+ASN+ G RN S + P+ + +LE++ +G+ L C V
Sbjct: 2413 ---TQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNV 2469
Query: 580 NKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSIT---LNLTIMNVSLQDSGTYAC 636
+TW + +A H I+ + L ++ +L +G Y+C
Sbjct: 2470 TGHPQPKLTWFK-------------DGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSC 2516
Query: 637 RARNVYTGEEILQKKEITIRDQEAPYLLRNLSDH-----TVAISSSTTLDCHANGVPEPQ 691
A N GE + K + AP +L D TV +++ +L C A P P
Sbjct: 2517 IAANA-VGE---KTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPN 2572
Query: 692 ITWFKN 697
ITW K+
Sbjct: 2573 ITWMKD 2578
Score = 74.7 bits (182), Expect = 3e-13
Identities = 145/648 (22%), Positives = 231/648 (35%), Gaps = 115/648 (17%)
Query: 94 LNTAQAN--HTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEG 151
L QAN G YSC +A +K + + ++ T E ++ E + +T
Sbjct: 2501 LQVLQANLSSAGHYSC--IAANAVGEKTKHFQLSVLLAPTILGGAEDSAD--EEVTVTVN 2556
Query: 152 RELVIPCRVT---SPNITVTLKKFPLDTLIPDGKRI-IWDSRKGFIISNATYKEIGLLTC 207
+ + C SPNIT P + + I + G I NA ++ G TC
Sbjct: 2557 NPISLICEALAFPSPNITWMKDGAPFEA----SRNIQLLPGTHGLQILNAQKEDAGQYTC 2612
Query: 208 EATVNGHLYKTNYLTHRQTNTIIDVQISTPRP--------VKLLRGHTLVLNCT--ATTP 257
T NY +I IS P VK TL L C A P
Sbjct: 2613 VVTNELGEAVKNY----HVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPP 2668
Query: 258 LNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS-- 315
R W Y D + S R ++ +L I Q D G Y C +
Sbjct: 2669 PTIR----W-YKDGQPVTPSSRLQVLGEGR-------LLQIQPTQVSDSGRYLCVATNVA 2716
Query: 316 GPSFKSVNTSVHI---------YDKAFITVKHRKQ------QVLETVAGKRSYRLSMKVK 360
G + N + + + AF + ++ + E V +Y L
Sbjct: 2717 GEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAY-LYCDTN 2775
Query: 361 AFPSPEVVWLKDGLPATE-KSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSN-VFKNL 418
A P P++ W ++ P + L G L I V E+AG Y S K SN V ++
Sbjct: 2776 AIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRY----SCKASNEVGEDW 2831
Query: 419 TATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEA 478
++ + P + + S L C A G P PTI W
Sbjct: 2832 LHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWL----------- 2880
Query: 479 RCDFCSNNEESFILDADSNMGNRIESITQRMAIIE-GKNKMASTLVVADSRISGIYICIA 537
N F S + R+ ++E G+ ST VAD+ Y+C+A
Sbjct: 2881 ------QNGLPF-------------SPSPRLQVLEDGQVLQVSTAEVADA---ASYMCVA 2918
Query: 538 SNKVGTVGRNISFYITDVPNGFHVNLEKMPTE-GEDLKLSCTVNKFLYRDVTWILLRTVN 596
N+ G+ + + + P ++LE++ + L C V+ +VTW
Sbjct: 2919 ENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWY------ 2972
Query: 597 NRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIR 656
+ S+ ++ + H++ L L DSG Y C A N ++ L + + +
Sbjct: 2973 KDSQALSLGEEVFLLPGTHTLQLG----RARLSDSGMYTCEALNAAGRDQKLVQLSVLVP 3028
Query: 657 D--QEAPYLLRNLSDHT-VAISSSTTLDCHANGVPEPQITWFKNNHKI 701
++AP R D V + L C + +PEP +TW+K+ +
Sbjct: 3029 PAFRQAP---RGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPL 3073
Score = 73.6 bits (179), Expect = 6e-13
Identities = 101/416 (24%), Positives = 148/416 (35%), Gaps = 66/416 (15%)
Query: 296 LTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSY 353
L I+K+ +D+G+YTC + G S + V K + V + V S
Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAGESKREVAL------KVLVPPNIEPGPVNKAVLENASV 1903
Query: 354 RLSMKVKAFPSPEVVWLKDGLPATE-KSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQS 412
L P P+V W K P + G L I+ DAG+Y + S
Sbjct: 1904 TLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAG 1963
Query: 413 NVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCN 472
+ L L VNV P+I S P P L R LTC A G P PT+ W
Sbjct: 1964 ST--ELRYGLRVNVPPRI--TLPPSLPGPVLVNTPVR--LTCNATGAPSPTLMWL----- 2012
Query: 473 HNHSEARCDFCSNNEESFILDADSNMGNRIESI-TQRMAIIEGKNKMASTLVVADSRISG 531
GN + T + + G + TL A + SG
Sbjct: 2013 ------------------------KDGNPVSPAGTPGLQVFPGGRVL--TLASARASDSG 2046
Query: 532 IYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWIL 591
Y C+A + VG +++ + P+ L E + L C + ++W
Sbjct: 2047 RYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWK 2106
Query: 592 L-RTVNNRT-MHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQ 649
R + R +H S K + + + + D+G Y C A N E
Sbjct: 2107 DGRPLEPRPGVHLSADKALLQVDR------------ADVWDAGHYTCEALNQAGHSE--- 2151
Query: 650 KKEITIRDQEAP-YLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE 704
K + AP + LR TV T+L C GVP P+I+W K+ + E
Sbjct: 2152 -KHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGE 2206
Score = 72.4 bits (176), Expect = 1e-12
Identities = 115/475 (24%), Positives = 177/475 (37%), Gaps = 75/475 (15%)
Query: 237 PRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVL 296
PR +K+L G L LNC A N Q++WS ++ R Q + H F ++
Sbjct: 1126 PRVLKVLVGEALDLNCVAEG--NPEPQLSWS-----KDGVVLQGRGPQGSVH---FAAIR 1175
Query: 297 TIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLS 356
T D G Y C + + + + + +LE VAG+ + L
Sbjct: 1176 T------SDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSG-LLERVAGENA-SLP 1227
Query: 357 MKVKAFPSPEVVWLKDGLPATEK-----SARYLTRGYSLIIKDVTEEDAGNYTILLSIKQ 411
+ P P+V W K P++E L G SL + V+ D+G+Y + +
Sbjct: 1228 CPARGTPKPQVTWRKG--PSSEPLHGQPGVAVLEEG-SLFLASVSPADSGDYECQATNEV 1284
Query: 412 SNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPC 471
+ + A L+V V P I E + G L C A G P P I W
Sbjct: 1285 GSTSRR--AKLVVYVPPSIREDGRKANVSGMA---GQSLTLECDANGFPVPEIVWL---- 1335
Query: 472 NHNHSEARCDFCSNNEESFILDADSNM--GNRIESITQRMAIIEGKNKMASTLVVADSRI 529
+A+ + D G+R+ + EG++ + DS
Sbjct: 1336 ----KDAQLVGVPLGWAGYGWDLGWGQVGGHRL--------LDEGQSLHFPRIQEGDS-- 1381
Query: 530 SGIYICIASNKVGTVGRNISFYITDVPN--GFHVNLEKMPTEGEDLKLSCTVNKFLYRDV 587
G+Y C A N+ GT R+ + P+ G E + G D++L C + V
Sbjct: 1382 -GLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQV 1440
Query: 588 TWILLRT-VNNRTMHYSISK--QKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTG 644
W R V H + + Q + IT H + D G Y C A + G
Sbjct: 1441 EWTKDRQPVLPGGPHLQVQEDGQVLRITGSH------------VGDEGRYQCVAFSP-AG 1487
Query: 645 EEILQKKEITIRDQEAPYLLRNLSDHTVAISSS--TTLDCHANGVPEPQITWFKN 697
+ Q ++ +R P + + VA+ L C A GVP P ITWFK+
Sbjct: 1488 Q---QARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKD 1539
Score = 71.6 bits (174), Expect = 2e-12
Identities = 141/688 (20%), Positives = 244/688 (35%), Gaps = 130/688 (18%)
Query: 42 IMQAGQTLHLQCRGEAAHKWSLPEMVS---KESERLSITKSACGRNGKQFCSTLTLNTAQ 98
+++ G L C +A LPE K+ + L + + G Q L + AQ
Sbjct: 3043 LVRVGDKAVLSCETDA-----LPEPTVTWYKDGQPLVLAQRTQALRGGQ---RLEIQEAQ 3094
Query: 99 ANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPC 158
+ G YSCK V + + + P E + E + G LV+ C
Sbjct: 3095 VSDKGLYSCKVSNVAGEAVRTFTLTVQV------PPTFE--NPKTETVSQVAGSPLVLTC 3146
Query: 159 RVT---SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFI-ISNATYKEIGLLTCEATVNGH 214
V+ +P +T + P+++ G SR G + +S + G TC A
Sbjct: 3147 DVSGVPAPTVTWLKDRMPVESSAVHGVV----SRGGRLQLSRLQPAQAGTYTCVAE---- 3198
Query: 215 LYKTNYLTHRQTNTIIDVQIS-------TPRPVKLLRGHTLVLNCTAT-TPLNTRVQMTW 266
N + + ++ V ++ R +L G + L+C A P +
Sbjct: 3199 ----NTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKD 3254
Query: 267 SYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSV 326
P ++ +R +D + L + ++ D G YTC V P+ + +
Sbjct: 3255 GSPLGQDMGPHLRFYLDGGS---------LVLKGLRASDAGAYTC-VAHNPAGEDAR--L 3302
Query: 327 HIYDKAFITVKHRKQQVLETVAGKRSYRLSM--KVKAFPSPEVVWLKDGLPATEKSARYL 384
H + + T+ + ++M V+ P V WLKDGLP L
Sbjct: 3303 HTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLL 3362
Query: 385 T-RGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPAL 443
G++L I V DAG +T + + +N T + V P + E F + +
Sbjct: 3363 HGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQV---PPVLEPV--EFQNDVV 3417
Query: 444 YPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIE 503
GS L C A G+P P + W + D + + +E
Sbjct: 3418 VVRGSLVELPCEARGVPLPLVSW------------------------MKDGEPLLSQSLE 3453
Query: 504 SITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNL 563
+G + + DS G Y C+A ++ G R+ + + P H+
Sbjct: 3454 ---------QGPSLQLEAVGAGDS---GTYSCVAVSEAGEARRHFQLTVMEPP---HIED 3498
Query: 564 EKMPTE-----GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSIT 618
PTE G ++L C ++TW K A+T+ + +
Sbjct: 3499 SGQPTELSLTPGAPMELLCDAQGTPQPNITW---------------HKDGQALTRLENNS 3543
Query: 619 LNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVA--ISS 676
++ V +D+G Y C A + E K +R Q P ++ V
Sbjct: 3544 RATRVLRV--RDAGLYTCLAESPAGAIE----KSFRVRVQAPPNIVGPRGPRFVVGLAPG 3597
Query: 677 STTLDCHANGVPEPQITWFKNNHKIQQE 704
L+C P P+ITW ++ +Q++
Sbjct: 3598 QLVLECSVEAEPAPKITWHRDGIVLQED 3625
Score = 71.6 bits (174), Expect = 2e-12
Identities = 84/324 (25%), Positives = 125/324 (38%), Gaps = 37/324 (11%)
Query: 149 TEGRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTC 207
TEG +PC+ SP +T K +GK I S + ++ N ++ G TC
Sbjct: 4050 TEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE-LLVKNLEGQDAGTYTC 4108
Query: 208 EA-TVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTW 266
A G + +LT ++ V + P L G L L C A R+ T
Sbjct: 4109 TAENAVGRARRRVHLTI----LVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT- 4163
Query: 267 SYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSV 326
N R +Q S L + +D G Y C + + V
Sbjct: 4164 -----VNDRPVTEGVSEQDGG------STLQRAAVSREDSGTYVCWAENRVGRTQAVSFV 4212
Query: 327 HIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTR 386
H+ + A + ++E V G S +L V+ P P++ W+KDGLP R+ +
Sbjct: 4213 HVKE-APVLQGEAFSYLVEPVGG--SIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQ 4269
Query: 387 GYSLIIKDVTEEDAGNYTIL----LSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPA 442
SL I +DAG Y L + + + V L + + V+PQ + V S D A
Sbjct: 4270 NGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQ--DMTVRSGDDVA 4327
Query: 443 LYPLGSRQILTCTAYGIPQPTIKW 466
L C A G P PTI+W
Sbjct: 4328 ---------LRCQATGEPTPTIEW 4342
Score = 68.9 bits (167), Expect = 2e-11
Identities = 148/751 (19%), Positives = 264/751 (35%), Gaps = 121/751 (16%)
Query: 32 PELSLKGTQHIMQAGQTLHLQCRGEAAH----KWSLPEMVSKESERLSITKSACGRNGKQ 87
P++S+ + G + + C WS +E R+ +
Sbjct: 608 PQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG------- 660
Query: 88 FCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIH 147
TL + G YSC+ T++ + + ++ +D P V S + ++
Sbjct: 661 ---TLIIQGVAPEDAGNYSCQ----ATNEVGTDQETVTLYYTDP--PSV---SAVNAVVL 708
Query: 148 MTEGRELVIPCRVTS-PNITVTLKKFPLDTLI-PDGKRIIWDSRKGFIISNATYKEIGLL 205
+ G E V+ C + P V + L+ ++ P+G S I A ++ G
Sbjct: 709 VAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS-----SSGKLRIPAAQERDAGTY 763
Query: 206 TCEATVN-GHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTAT-TPLNTRVQ 263
TC A G L + ++ PR V + G + +L C AT P T
Sbjct: 764 TCRAVNELGDASAEIQLAVGHAPQLTEL----PRDVTVELGRSALLACRATGRPPPT--- 816
Query: 264 MTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVN 323
+TW D + +R + + VL + + +D+ Y C R+ F V
Sbjct: 817 VTWRRGD--GQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARN--VFGKVQ 872
Query: 324 TSVHIYDKAFITVKHRKQQV------LETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPAT 377
+ I H Q+ + + G+ + + P PE WLKDG P
Sbjct: 873 AEARL-----IVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLP 927
Query: 378 EKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSS 437
S + SL + +E AG Y+ + + + +++ L+V V P+I+ A
Sbjct: 928 PGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDV--ELVVQVPPRIHPTATHH 985
Query: 438 FPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSN 497
+ G L C A G+P PTI W N +R + ++E +L A +
Sbjct: 986 ITNE-----GVPASLPCVASGVPAPTITW---TKETNALTSRGPHYNVSKEGTLLIAQPS 1037
Query: 498 ----------MGNRIESITQRMAIIEGKNKM------------ASTLVVADSRI--SGIY 533
N + +Q M + + + + +L +A ++ SG Y
Sbjct: 1038 AQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHY 1097
Query: 534 ICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLR 593
C ASN G+ + P GE L L+C ++W
Sbjct: 1098 ECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSW---- 1153
Query: 594 TVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEI 653
+ + + ++ + D+G Y C A N + E+
Sbjct: 1154 ------------SKDGVVLQGRGPQGSVHFAAIRTSDAGRYRCEASN----SAGVDAWEV 1197
Query: 654 TIRDQEAPYLLRNLSDHTV--AISSSTTLDCHANGVPEPQITWFKNNHK----------I 701
+R E P+ + + + + +L C A G P+PQ+TW K +
Sbjct: 1198 ELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAV 1257
Query: 702 QQEPELY-TSTSPSSSSSSPLSSSSSSSSSS 731
+E L+ S SP+ S +++ S+S
Sbjct: 1258 LEEGSLFLASVSPADSGDYECQATNEVGSTS 1288
Score = 67.0 bits (162), Expect = 6e-11
Identities = 120/560 (21%), Positives = 207/560 (36%), Gaps = 88/560 (15%)
Query: 160 VTSPNITVTLKKFPLDTLIPDGKRIIWD-SRKGFIISNATYKEIGLLTCEATVNGHLYKT 218
V +PNIT F L+P ++++ + + A + G+ TC+A+
Sbjct: 1529 VPTPNITW----FKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKAS-------- 1576
Query: 219 NYLTHRQTNTIIDVQI--------STPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPD 270
N + + T +DV + P VK + G + L C A T S+
Sbjct: 1577 NAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVA----RGHPSPTLSWHH 1632
Query: 271 EKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSV-NTSVHIY 329
E A + + S SVL ++ GLY+C V S P+ ++V SV +
Sbjct: 1633 EGLPVA------ESNESRLETDGSVLRLESPGEASSGLYSC-VASSPAGEAVLQYSVEVQ 1685
Query: 330 DKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSA-RYLTRGY 388
+ V QV T+ G+ L + P P + WL++G PA E + + ++G
Sbjct: 1686 VPPQLLVAEGLGQVT-TIVGQ-PLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGT 1743
Query: 389 SLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGS 448
+L I V + +G L + + +N A + V+V + P P+G
Sbjct: 1744 TLHIDHVELDHSG----LFACQATNEAGTAGAEVEVSVHGEWA-------PGVLEVPIG- 1791
Query: 449 RQILTCTAYGIPQPTIKWFWHPCNHNHSEARCD-----FCSNNEESFILDADSNMGNRIE 503
++ W +H+ A CD + + +++ + G
Sbjct: 1792 ----------------QYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPG---- 1831
Query: 504 SITQRMAIIEGKNKMASTLVV--ADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHV 561
S+ I + L + D R GIY C A+N G R ++ + PN
Sbjct: 1832 SLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPG 1891
Query: 562 NLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNL 621
+ K E + L C + DV+W + M ++S L
Sbjct: 1892 PVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRV----------L 1941
Query: 622 TIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLD 681
I L D+G+Y C A NV E+ + + + L V +++ L
Sbjct: 1942 RIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPR---ITLPPSLPGPVLVNTPVRLT 1998
Query: 682 CHANGVPEPQITWFKNNHKI 701
C+A G P P + W K+ + +
Sbjct: 1999 CNATGAPSPTLMWLKDGNPV 2018
Score = 62.4 bits (150), Expect = 1e-09
Identities = 48/206 (23%), Positives = 95/206 (46%), Gaps = 28/206 (13%)
Query: 506 TQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPN-GFHVNLE 564
T R+A + + S ++ D G Y C+ASN G ++ + + P H + +
Sbjct: 561 TGRVAQLADLSLEISGIIPTDG---GRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQ 617
Query: 565 KMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLN---- 620
++G ++K+SC+ + + T H S S++ A+ ++ I ++
Sbjct: 618 HF-SQGVEVKVSCSASGY---------------PTPHISWSRESQALQEDSRIHVDAQGT 661
Query: 621 LTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTL 680
L I V+ +D+G Y+C+A N E ++ +T+ + P + + VA+ L
Sbjct: 662 LIIQGVAPEDAGNYSCQATN----EVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVL 717
Query: 681 DCHANGVPEPQITWFKNNHKIQQEPE 706
C A+GVP P++ W++ ++ PE
Sbjct: 718 VCEASGVPPPRVIWYRGGLEMILAPE 743
Score = 61.2 bits (147), Expect = 3e-09
Identities = 95/447 (21%), Positives = 168/447 (37%), Gaps = 92/447 (20%)
Query: 296 LTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAF-------ITVKHRKQQVLET 346
L I Q +D G YTC V + G + K+ + V I + VK K +V T
Sbjct: 2597 LQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNST 2656
Query: 347 VAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSA-RYLTRGYSLIIKDVTEEDAGNYTI 405
+ L + A P P + W KDG P T S + L G L I+ D+G Y
Sbjct: 2657 LT------LECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLC 2710
Query: 406 LLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQ--------------- 450
+ + ++ + V P +++K V F A + + SR+
Sbjct: 2711 VATNVAGEDDQDFNVLIQV---PPMFQK-VGDFS--AAFEILSREEEARGGVTEYREIVE 2764
Query: 451 ----ILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESIT 506
L C IP P + W+ D + G+ +
Sbjct: 2765 NNPAYLYCDTNAIPPPDLTWYRE-----------------------DQPLSAGDEV---- 2797
Query: 507 QRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVP----NGFHVN 562
++++G + LV A++ +G Y C ASN+VG + + P + +
Sbjct: 2798 ---SVLQGGRVLQIPLVRAEN--AGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELV 2852
Query: 563 LEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLT 622
E + L C ++W+ + +S S ++ + ++ + L
Sbjct: 2853 EEVTVNASSTVSLQCPALGNPVPTISWL------QNGLPFSPSP-RLQVLEDGQV---LQ 2902
Query: 623 IMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLR-NLSDHTVAISSSTTLD 681
+ + D+ +Y C A N E K T+R Q P + +L T ++SS +L
Sbjct: 2903 VSTAEVADAASYMCVAENQAGSAE----KLFTLRVQVPPRIAGLDLEQVTAILNSSVSLP 2958
Query: 682 CHANGVPEPQITWFKNNHKIQQEPELY 708
C + P P++TW+K++ + E++
Sbjct: 2959 CDVHAHPNPEVTWYKDSQALSLGEEVF 2985
Score = 60.1 bits (144), Expect = 7e-09
Identities = 130/612 (21%), Positives = 208/612 (33%), Gaps = 91/612 (14%)
Query: 91 TLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTE 150
+L L A +G YSC V S+ E + + + P +E + P + +T
Sbjct: 3457 SLQLEAVGAGDSGTYSC----VAVSEAGEARRHFQLTVMEP--PHIEDSGQ-PTELSLTP 3509
Query: 151 GRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEA 209
G + + C +P +T K DG+ + ++ GL TC A
Sbjct: 3510 GAPMELLCDAQGTPQPNITWHK--------DGQALTRLENNSRATRVLRVRDAGLYTCLA 3561
Query: 210 TVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYP 269
+ ++ Q I V PR V L LVL C+ ++ TW
Sbjct: 3562 ESPAGAIEKSFRVRVQAPPNI-VGPRGPRFVVGLAPGQLVLECSVEAEPAPKI--TWH-- 3616
Query: 270 DEKNKRASVRRRIDQSNSHANIFYS--VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVH 327
R + + Q ++H L + + D G Y+C R+ SV V
Sbjct: 3617 -----RDGI---VLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVE 3668
Query: 328 IYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARY--LT 385
I+ I R V+ ++ L + P+P V W KD +P +S R+ L
Sbjct: 3669 IHTVPTI----RSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILP 3724
Query: 386 RGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYP 445
G SL I+ V +DAG+Y L S + + + + A++ P
Sbjct: 3725 EG-SLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRV-------LEPPAIAPSPSNLTLT 3776
Query: 446 LGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESI 505
+ +L C A G P+P + W+ + DF R++
Sbjct: 3777 AHTPALLPCEASGSPKPLVVWW-------KDGQKLDF------------------RLQQG 3811
Query: 506 TQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEK 565
R+ A L + S + C+ SN+VG R + P +
Sbjct: 3812 AYRLL-----PSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDF 3866
Query: 566 MPTEGEDLKLSCTVNKFLYRDVTWILL-RTVNNRTMHYSISKQKMAITKEHSITLNLTIM 624
T + L+C V+W + R Y +S L I
Sbjct: 3867 TVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGA-----------LEIG 3915
Query: 625 NVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHA 684
+G Y C ARN + K + + Q +P + S L C A
Sbjct: 3916 QALPIHAGRYTCSARN----SAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEA 3971
Query: 685 NGVPEPQITWFK 696
+G+P P ITW K
Sbjct: 3972 SGIPRPTITWQK 3983
Score = 59.7 bits (143), Expect = 9e-09
Identities = 76/354 (21%), Positives = 129/354 (36%), Gaps = 65/354 (18%)
Query: 355 LSMKVKAFPSPEVVWLKDGLPAT---EKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQ 411
L + P P VVW KDG ++ A L +L++ +D+ + ++S +
Sbjct: 3783 LPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEV 3842
Query: 412 SNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPC 471
+ T V+V P I + + F + P+ +LTC + GIP PT+ W
Sbjct: 3843 GEAHRLYQVT--VHVPPTIADDQ-TDFTVTMMAPV----VLTCHSTGIPAPTVSW----- 3890
Query: 472 NHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISG 531
S+A + G R+ G ++ L + +G
Sbjct: 3891 ----SKAGAQLGARGS-----------GYRVSP--------SGALEIGQALPIH----AG 3923
Query: 532 IYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWIL 591
Y C A N G +++ + P + E++ L C + +TW
Sbjct: 3924 RYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITW-- 3981
Query: 592 LRTVNNRTMHYSISKQKMAITKEHSITL----NLTIMNVSLQDSGTYACRARNVYTGEEI 647
K+ + + S + L I + S +D+G Y C A+N +
Sbjct: 3982 -------------QKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKN--SAGSA 4026
Query: 648 LQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKI 701
+ K + + Q P + L D + S L C A G PEP ITW K+ +
Sbjct: 4027 MGKTRLVV--QVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPV 4078
Score = 58.5 bits (140), Expect = 2e-08
Identities = 112/564 (19%), Positives = 207/564 (36%), Gaps = 106/564 (18%)
Query: 92 LTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEG 151
L + A H G Y+C +++ + ++F++ P V+ +P ++
Sbjct: 3912 LEIGQALPIHAGRYTC------SARNSAGVAHKHVFLTVQASPVVK---PLPSVVRAVAE 3962
Query: 152 RELVIPCRVTS-PNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEA- 209
E+++PC + P T+T +K L+ +++ + I++A+ ++ G C A
Sbjct: 3963 EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQ--LRIAHASPEDAGNYLCIAK 4020
Query: 210 -TVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSY 268
+ + KT + Q +I+ + + G L C A + +TW
Sbjct: 4021 NSAGSAMGKTRLVV--QVPPVIENGLPD---LSTTEGSHAFLPCKARG--SPEPNITWDK 4073
Query: 269 PDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSV 326
+ A + I S L + ++ +D G YTC + G + + V+ ++
Sbjct: 4074 DGQPVSGAEGKFTIQPSGE--------LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTI 4125
Query: 327 HIYDKAFITVKHRKQQVLETVAGKRSYRLSMKV------KAFPSPEVVWLKDGLPATEKS 380
+ V T+ G RS RL ++ + P+P + W + P TE
Sbjct: 4126 LVLP------------VFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV 4173
Query: 381 ARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVK--PQIYEKAVSSF 438
+ G +L V+ ED+G Y N A V+VK P + +A S
Sbjct: 4174 SEQ-DGGSTLQRAAVSREDSGTYVCWAE----NRVGRTQAVSFVHVKEAPVLQGEAFSYL 4228
Query: 439 PDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNM 498
+P +G L C G P P I W I D
Sbjct: 4229 VEP----VGGSIQLDCVVRGDPVPDIHW------------------------IKDGLPLR 4260
Query: 499 GNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNG 558
G+ + Q ++ T+ + +G Y C+A N++G + + + P
Sbjct: 4261 GSHLRHQLQNGSL---------TIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPV- 4310
Query: 559 FHVNLEKMPTE-GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSI 617
F V + M G+D+ L C + W+ + + +++ + S+
Sbjct: 4311 FQVEPQDMTVRSGDDVALRCQATGEPTPTIEWL-------QAGQPLRASRRLRTLPDGSL 4363
Query: 618 TLNLTIMNVSLQDSGTYACRARNV 641
L NV D+GTY C A N+
Sbjct: 4364 WLE----NVETGDAGTYDCVAHNL 4383
Score = 57.8 bits (138), Expect = 4e-08
Identities = 75/347 (21%), Positives = 121/347 (34%), Gaps = 65/347 (18%)
Query: 363 PSPEVVWLKDGLPATEKSARY-LTRGYSLIIKDVTEEDAGNYTILL----SIKQSNVFKN 417
P+P V W K G + + Y ++ +L I AG YT + +VF
Sbjct: 3884 PAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLT 3943
Query: 418 LTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSE 477
+ A+ +V P + +AV+ +L C A GIP+PTI W
Sbjct: 3944 VQASPVVKPLPSVV-RAVAE----------EEVLLPCEASGIPRPTITW----------- 3981
Query: 478 ARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIA 537
G + + + G+ ++A A +G Y+CIA
Sbjct: 3982 ------------------QKEGLNVATGVSTQVLPGGQLRIAH----ASPEDAGNYLCIA 4019
Query: 538 SNKVGTVGRNISFYITDVPNGFHVNLEKMPT-EGEDLKLSCTVNKFLYRDVTWILLRTVN 596
N G+ + VP L + T EG L C ++TW +
Sbjct: 4020 KNSAGSAMGKTRL-VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITW------D 4072
Query: 597 NRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIR 656
S ++ K I L + N+ QD+GTY C A N ++ + +
Sbjct: 4073 KDGQPVSGAEGKFTIQPSGE----LLVKNLEGQDAGTYTCTAENAVG----RARRRVHLT 4124
Query: 657 DQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQ 703
P D ++ + L C A G P P+I W N+ + +
Sbjct: 4125 ILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTE 4171
Score = 57.0 bits (136), Expect = 6e-08
Identities = 96/463 (20%), Positives = 164/463 (35%), Gaps = 93/463 (20%)
Query: 305 DKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPS 364
D G Y C+ + S + +Y I RK V +AG+ S L FP
Sbjct: 1272 DSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANV-SGMAGQ-SLTLECDANGFPV 1329
Query: 365 PEVVWLKD----GLP------------ATEKSARYLTRGYSLIIKDVTEEDAGNYTILLS 408
PE+VWLKD G+P R L G SL + E D+G Y+
Sbjct: 1330 PEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAE 1389
Query: 409 IKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFW 468
+ ++ L+V P + + L G+ L C G+P P ++W
Sbjct: 1390 NQAGTAQRDFH--LLVLTPPSVLGAGAAQ---EVLGLAGADVELQCWTSGVPTPQVEW-- 1442
Query: 469 HPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSR 528
+ +L ++ + + R I G + V D
Sbjct: 1443 ----------------TKDRQPVLPGGPHLQVQEDGQVLR---ITGSH-------VGDE- 1475
Query: 529 ISGIYICIASNKVGTVGRNISFYITDVPN--GFHVNLEKMPTEGEDLKLSCTVNKFLYRD 586
G Y C+A + G R+ + P G + E E ++L C +
Sbjct: 1476 --GRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPN 1533
Query: 587 VTWI----LLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVY 642
+TW LL T + + Y+ +++ + + S D+G Y C+A N
Sbjct: 1534 ITWFKDGALLPT--STKVVYTRGGRQLQLGRAQS------------SDAGVYTCKASNAV 1579
Query: 643 TGEEILQKKEITIRDQ-----EAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWF-- 695
E + ++ + PY+++ ++ VA L+C A G P P ++W
Sbjct: 1580 GAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVA------LECVARGHPSPTLSWHHE 1633
Query: 696 ------KNNHKIQQEPELYTSTSPSSSSSSPLSSSSSSSSSSS 732
N +++ + + SP +SS S +SS + +
Sbjct: 1634 GLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEA 1676
Score = 55.5 bits (132), Expect = 2e-07
Identities = 140/670 (20%), Positives = 237/670 (35%), Gaps = 132/670 (19%)
Query: 77 TKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFV 136
TK R G+Q L L AQ++ G Y+CK + +K T +Y+ P +
Sbjct: 1547 TKVVYTRGGRQ----LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYV------PPTI 1596
Query: 137 EMYSEIPEIIHMTEGRELVIPCRVTS-PNITVTLKKFPLDTLIPDGKRIIWDSRKGFIIS 195
E P ++ GR + + C P+ T++ L + R+ D +
Sbjct: 1597 EGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSV-LRLE 1655
Query: 196 NATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTAT 255
+ GL +C A+ Y Q + V + V + G L L C A+
Sbjct: 1656 SPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQ-VTTIVGQPLELPCQAS 1714
Query: 256 -TPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRV- 313
+P+ T + P E+ V + + L ID ++ GL+ C+
Sbjct: 1715 GSPVPTIQWLQNGRPAEELAGVQVASQ-----------GTTLHIDHVELDHSGLFACQAT 1763
Query: 314 -RSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK------------ 360
+G + V SVH VLE G+ +
Sbjct: 1764 NEAGTAGAEVEVSVH---------GEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRG 1814
Query: 361 --AFPSPEVV--WLKDGLPATEKSARYLTRGYSLI----IKDVTEEDAGNYTILLSIKQS 412
A P P +V W G E + + YSL I+ V D G YT +
Sbjct: 1815 WGAHPKPPLVEGWCSPGSLWGEPTG--IPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAG 1872
Query: 413 NVFKNLTATLIV--NVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHP 470
+ + ++V N++P KAV + L C A G+P P + WF
Sbjct: 1873 ESKREVALKVLVPPNIEPGPVNKAVLE---------NASVTLECLASGVPPPDVSWF--- 1920
Query: 471 CNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS 530
H S MG + S+ R+ IE A +
Sbjct: 1921 --KGHQPV----------------SSWMGVTV-SVDGRVLRIEQ----------AQLSDA 1951
Query: 531 GIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDL----------KLSCTVN 580
G Y C+ASN G+ T++ G VN+ T L +L+C
Sbjct: 1952 GSYRCVASNVAGS---------TELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNAT 2002
Query: 581 KFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
+ W L+ N + + Q + LT+ + DSG Y+C A +
Sbjct: 2003 GAPSPTLMW--LKDGNPVSPAGTPGLQVFPGGRV------LTLASARASDSGRYSCVAVS 2054
Query: 641 VYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHK 700
GE+ ++++ ++ P +L + +V + S L+C ++ +P P ++W+K+
Sbjct: 2055 A-VGED---RQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRP 2110
Query: 701 IQQEPELYTS 710
++ P ++ S
Sbjct: 2111 LEPRPGVHLS 2120
Score = 55.1 bits (131), Expect = 2e-07
Identities = 87/423 (20%), Positives = 153/423 (36%), Gaps = 65/423 (15%)
Query: 295 VLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRS 352
VLT+ + D G Y+C S G + V VH+ +++ +V S
Sbjct: 2034 VLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSIL------GEELNVSVVANES 2087
Query: 353 YRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEE-DAGNYTILLSIKQ 411
L + A P P + W KDG P + +L+ +L+ D + DAG+YT +
Sbjct: 2088 VALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQA 2147
Query: 412 SNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPC 471
+ K+ + V + E + + G L+C G+P P I W
Sbjct: 2148 GHSEKHYNLNVWVAPVFPLRESHTLTVRE------GHPTSLSCECRGVPFPKISW----- 2196
Query: 472 NHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISG 531
++ L + + ++ + + + G+ ++A G
Sbjct: 2197 --------------RKDGQPLPGEGAGLQHVSAVGRLLYL--GQAQLAQ---------EG 2231
Query: 532 IYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLK-----LSCTVNKFLYRD 586
Y C SN VG +++ + P + PT+ ++ L C
Sbjct: 2232 TYTCECSNVVGNSSQDLQLEVHVPPQ--IAGPREPPTQVSVVQDGVATLECNATGKPPPT 2289
Query: 587 VTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEE 646
VTW + + Q ++ E + +G Y+C A N+ E
Sbjct: 2290 VTWERDGQPVGAELGLQLQNQGQSLHVERA----------QAAHTGRYSCVAENLAGRAE 2339
Query: 647 ILQKKEITIR-DQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEP 705
+K E+++ E L L++ T A+ S TL C A G+P P I WF+ +
Sbjct: 2340 --RKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGE 2397
Query: 706 ELY 708
+ Y
Sbjct: 2398 DTY 2400
Score = 53.9 bits (128), Expect = 5e-07
Identities = 88/425 (20%), Positives = 152/425 (35%), Gaps = 67/425 (15%)
Query: 288 HANIFYSVLTIDKMQNKDKGLYTCRV--RSGPSFKSVNTSVHIYDKAFITVKHRKQQVLE 345
H + ++L +D+ D G YTC ++G S K N +V + + H
Sbjct: 2118 HLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTL----- 2172
Query: 346 TVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSA---RYLTRGYSLIIKDVTEEDAGN 402
TV LS + + P P++ W KDG P + A G L + G
Sbjct: 2173 TVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGT 2232
Query: 403 YTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQP 462
YT S N ++L L V+V PQI P L C A G P P
Sbjct: 2233 YTCECSNVVGNSSQDL--QLEVHVPPQI--AGPREPPTQVSVVQDGVATLECNATGKPPP 2288
Query: 463 TIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTL 522
T+ W E + +G ++++ Q + +
Sbjct: 2289 TVTW---------------------ERDGQPVGAELGLQLQNQGQSLHVER--------- 2318
Query: 523 VVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKF 582
A + +G Y C+A N G R F +++ P DL +
Sbjct: 2319 --AQAAHTGRYSCVAENLAGRAERK-----------FELSVLVPPELIGDLDPLTNITAA 2365
Query: 583 LYRDVTWIL-LRTVNNRTMHYSISKQKMAITKEHSITLN---LTIMNVSLQDSGTYACRA 638
L+ +T + + + + ++ ++ ++ + L + QDSG Y+C A
Sbjct: 2366 LHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLA 2425
Query: 639 RNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTT--LDCHANGVPEPQITWFK 696
N GE ++ ++ P + + + + T L C+ G P+P++TWFK
Sbjct: 2426 SN-EAGE---ARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFK 2481
Query: 697 NNHKI 701
+ +
Sbjct: 2482 DGRPL 2486
Score = 53.9 bits (128), Expect = 5e-07
Identities = 123/614 (20%), Positives = 214/614 (34%), Gaps = 86/614 (14%)
Query: 91 TLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTE 150
+L L +A+ G Y+C + E A ++ P ++ ++ +
Sbjct: 3274 SLVLKGLRASDAGAYTC------VAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRP 3327
Query: 151 GRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEA 209
G + + C V SP I V+ K L + + ++ S IS + G+ TC A
Sbjct: 3328 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQ-RTLLHGSGHTLRISKVQLADAGIFTCVA 3386
Query: 210 TVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTAT-TPLNTRVQMTWSY 268
+ N+ Q +++ + V ++RG + L C A PL ++W
Sbjct: 3387 ASPAGVADRNFTLQVQVPPVLE-PVEFQNDVVVVRGSLVELPCEARGVPLPL---VSWM- 3441
Query: 269 PDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHI 328
K+ + + ++Q S L ++ + D G Y+C S + + +
Sbjct: 3442 ---KDGEPLLSQSLEQGPS--------LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTV 3490
Query: 329 YDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGY 388
+ I + ++ T L + P P + W KDG T
Sbjct: 3491 MEPPHIEDSGQPTELSLTPGAPME--LLCDAQGTPQPNITWHKDGQALTR------LENN 3542
Query: 389 SLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGS 448
S + + DAG YT L + K+ V P I F L P
Sbjct: 3543 SRATRVLRVRDAGLYTCLAESPAGAIEKSFRVR--VQAPPNIVGPRGPRFV-VGLAP--G 3597
Query: 449 RQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQR 508
+ +L C+ P P I W + + +L D++ +R
Sbjct: 3598 QLVLECSVEAEPAPKITW-------------------HRDGIVLQEDAHT-----QFPER 3633
Query: 509 MAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPT 568
G+ L ADS G Y C A N G+ I VP +
Sbjct: 3634 -----GRFLQLQALSTADS---GDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVS 3685
Query: 569 EGEDLKLSCTVNKFLYRDVTWILLRT-VNNRTMHYSISKQKMAITKEHSITLNLTIMNVS 627
+ L C + V+W R ++ R+ + I + +L I V
Sbjct: 3686 VNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEG-----------SLRIQPVL 3734
Query: 628 LQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGV 687
QD+G Y C A N + ++ +R E P + + S+ T+ + L C A+G
Sbjct: 3735 AQDAGHYLCLASNSAGSD----RQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGS 3790
Query: 688 PEPQITWFKNNHKI 701
P+P + W+K+ K+
Sbjct: 3791 PKPLVVWWKDGQKL 3804
Score = 52.4 bits (124), Expect = 2e-06
Identities = 93/378 (24%), Positives = 139/378 (36%), Gaps = 63/378 (16%)
Query: 295 VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYR 354
VL I D+G Y C S ++ + + ++ I + +V V +
Sbjct: 1464 VLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEV--AVMEDHLVQ 1521
Query: 355 LSMKVKAFPSPEVVWLKDG-LPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSN 413
L + + P+P + W KDG L T Y G L + DAG YT K SN
Sbjct: 1522 LLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYT----CKASN 1577
Query: 414 VF--KNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPC 471
L V V P I + P G L C A G P PT+ W
Sbjct: 1578 AVGAAEKATRLDVYVPPTI--EGAGGRPYVVKAVAGRPVALECVARGHPSPTLSW----- 1630
Query: 472 NHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISG 531
H E +NE L+ D ++ R+ES SG
Sbjct: 1631 ---HHEG-LPVAESNESR--LETDGSV-LRLES--------------------PGEASSG 1663
Query: 532 IYICIASNKVGTVGRNISFYITDVPNGFHV--NLEKMPT-EGEDLKLSCTVNKFLYRDVT 588
+Y C+AS+ G S + VP V L ++ T G+ L+L C + +
Sbjct: 1664 LYSCVASSPAGEAVLQYSVEV-QVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQ 1722
Query: 589 WILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNV--YTGEE 646
W+ N R +++A + S L I +V L SG +AC+A N G E
Sbjct: 1723 WL----QNGR------PAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAE 1772
Query: 647 ILQKKEITIRDQEAPYLL 664
+ E+++ + AP +L
Sbjct: 1773 V----EVSVHGEWAPGVL 1786
Score = 48.5 bits (114), Expect = 2e-05
Identities = 40/178 (22%), Positives = 70/178 (39%), Gaps = 14/178 (7%)
Query: 531 GIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWI 590
G Y C A ++ GT +TD P + GE LSC V ++TW+
Sbjct: 492 GTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWV 551
Query: 591 LLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQK 650
+ R + S + L+L I + D G Y C A N + +
Sbjct: 552 R----DWRVLPASTGRVAQLAD------LSLEISGIIPTDGGRYQCVASNANG----VTR 597
Query: 651 KEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPELY 708
+ + +EAP + + S + + C A+G P P I+W + + +Q++ ++
Sbjct: 598 ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIH 655
Score = 30.8 bits (68), Expect = 4.7
Identities = 34/137 (24%), Positives = 54/137 (39%), Gaps = 12/137 (8%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
LTI + + D G Y C + + + V+ + TV L
Sbjct: 4273 LTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDM----TVRSGDDVAL 4328
Query: 356 SMKVKAFPSPEVVWLKDGLP-ATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNV 414
+ P+P + WL+ G P + R L G SL +++V DAG Y + N+
Sbjct: 4329 RCQATGEPTPTIEWLQAGQPLRASRRLRTLPDG-SLWLENVETGDAGTYDCV----AHNL 4383
Query: 415 FKNLTAT--LIVNVKPQ 429
+ TA L+V +PQ
Sbjct: 4384 LGSATARAFLVVRGEPQ 4400
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 85.5 bits (210), Expect = 2e-16
Identities = 100/421 (23%), Positives = 164/421 (38%), Gaps = 67/421 (15%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
L + + Q+ D G+YTC+ + T + +Y I + V++ VAG R L
Sbjct: 276 LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAG-RPVAL 334
Query: 356 SMKVKAFPSPEVVWLKDGLPATEKS-ARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNV 414
+ PSP + W +GLP E + +R T G L ++ E +G Y+ + S
Sbjct: 335 ECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEA 394
Query: 415 FKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHN 474
L ++ V V PQ+ V+ +G L C A G P PTI+W +
Sbjct: 395 V--LQYSVEVQVPPQL---LVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQN----- 444
Query: 475 HSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRI--SGI 532
G E + +G +TL + + SG+
Sbjct: 445 ------------------------GRPAEELAGVQVASQG-----TTLHIDHVELDHSGL 475
Query: 533 YICIASNKVGTVGRNISFY--------ITDVPNG-FHVNLEKMPTEGEDLKLSCTVNKFL 583
+ C A+N+ GT G + + +VP G +H E + +
Sbjct: 476 FACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXE------HHSSFPAACDPPV 529
Query: 584 YRDVTW---ILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
+R W V S+ + I +S+ L I V L+D G Y C A N
Sbjct: 530 HRG--WGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATN 587
Query: 641 VYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHK 700
+ GE K+E+ ++ P + + V ++S TL+C A+GVP P ++WFK +
Sbjct: 588 L-AGE---SKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQP 643
Query: 701 I 701
+
Sbjct: 644 V 644
Score = 84.3 bits (207), Expect = 4e-16
Identities = 99/397 (24%), Positives = 146/397 (36%), Gaps = 70/397 (17%)
Query: 307 GLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRK-----QQVLETVAGKRSYRLSMKVKA 361
G YTC R N++ + F+TV+ V+ VA + L +
Sbjct: 2641 GRYTCSAR--------NSAGVAHKHVFLTVQASPVVKPLPSVVRAVA-EEEVLLPCEASG 2691
Query: 362 FPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTAT 421
P P + W K+GL + + G L I + EDAGNY L I +++ + T
Sbjct: 2692 IPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNY---LCIAKNSAGSAMGKT 2748
Query: 422 LIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCD 481
+V P + E + PD + GS L C A G P+P I W
Sbjct: 2749 RLVVQVPPVIENGL---PDLSTTE-GSHAFLPCKARGSPEPNITW--------------- 2789
Query: 482 FCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKV 541
D D G + + I + L D+ G Y C A N V
Sbjct: 2790 -----------DKD---GQPVSGAEGKFTIQPSGELLVKNLEGQDA---GTYTCTAENAV 2832
Query: 542 GTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMH 601
G R + I +P + ++ G+ L L C + W TVN+R +
Sbjct: 2833 GRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGW----TVNDRPVT 2888
Query: 602 YSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAP 661
+S+Q T + + VS +DSGTY C A N + + + +EAP
Sbjct: 2889 EGVSEQDGGSTLQRAA--------VSREDSGTYVCWAENRVGRTQAVS----FVHVKEAP 2936
Query: 662 YLLRNLSDHTV-AISSSTTLDCHANGVPEPQITWFKN 697
L + V + S LDC G P P I W K+
Sbjct: 2937 VLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKD 2973
Score = 81.3 bits (199), Expect = 3e-15
Identities = 136/665 (20%), Positives = 247/665 (37%), Gaps = 133/665 (20%)
Query: 91 TLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTE 150
+L + AQA HTG YSC +A + + E + + + + E+ ++ + ++T
Sbjct: 1031 SLHVERAQAAHTGRYSC--VAENLAGRAERKFELSVLVPP------ELIGDLDPLTNITA 1082
Query: 151 GRE--LVIPCR---VTSPNITVTLKKFPL----DTLIPDGKRIIWDSRKGFIISNATYKE 201
L + C + P I + P+ DT + G ++ ++ ++
Sbjct: 1083 ALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLK-------MTQTQEQD 1135
Query: 202 IGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTR 261
GL +C A+ + N+ I+ + +K+L G T L C T + +
Sbjct: 1136 SGLYSCLASNEAGEARRNFSVEVLVPPSIENE-DLEEVIKVLDGQTAHLMCNVTG--HPQ 1192
Query: 262 VQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS--GPSF 319
++TW R H + +L + + G Y+C + G
Sbjct: 1193 PKLTWFKDGRPLARGDAH--------HISPDGVLLQVLQANLSSAGHYSCIAANAVGEKT 1244
Query: 320 KSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLP-ATE 378
K SV + + + + TV L + AFPSP + W+KDG P
Sbjct: 1245 KHFQLSVLLAPTILGGAEDSADEEV-TVTVNNPISLICEALAFPSPNITWMKDGAPFEAS 1303
Query: 379 KSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSF 438
++ + L + L I + +EDAG YT +++ + KN +++ P I +
Sbjct: 1304 RNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLI--PPSISK------ 1355
Query: 439 PDPALYPLGSRQILT---------CTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEES 489
D L +G +++ T C ++ +P PTI+W+
Sbjct: 1356 -DDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWY---------------------- 1392
Query: 490 FILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNIS 549
G + ++ + EG+ V+DS G Y+C+A+N G ++ +
Sbjct: 1393 -------KDGQPVTPSSRLQVLGEGRLLQIQPTQVSDS---GRYLCVATNVAGEDDQDFN 1442
Query: 550 FYITDVP-----NGFHVNLEKMPTEGE---------------DLKLSCTVNKFLYRDVTW 589
I P F E + E E L C N D+TW
Sbjct: 1443 VLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTW 1502
Query: 590 ILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSL---QDSGTYACRARNVYTGEE 646
Q ++ E S+ ++ + L +++G Y+C+A N GE+
Sbjct: 1503 YR-------------EDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNE-VGED 1548
Query: 647 ILQKKEITIRDQEAPYLLRN----LSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQ 702
L + + + P +L + + + TV SS+ +L C A G P P I+W +N
Sbjct: 1549 WLHYELLVLTP---PVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFS 1605
Query: 703 QEPEL 707
P L
Sbjct: 1606 PSPRL 1610
Score = 80.5 bits (197), Expect = 5e-15
Identities = 94/409 (22%), Positives = 151/409 (36%), Gaps = 75/409 (18%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
L I K+Q D G++TC S N ++ + + + V+ V L
Sbjct: 2087 LRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVV--VVRGSLVEL 2144
Query: 356 SMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVF 415
+ + P P V W+KDG P +S L +G SL ++ V D+G Y+ + +
Sbjct: 2145 PCEARGVPLPLVSWMKDGEPLLSQS---LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEAR 2201
Query: 416 KNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNH 475
++ T++ P I + S P G+ L C A G PQP I W H
Sbjct: 2202 RHFQLTVME--PPHIED---SGQPTELSLTPGAPMELLCDAQGTPQPNITW--------H 2248
Query: 476 SEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYIC 535
+ Q + +E ++ L V D+ G+Y C
Sbjct: 2249 KDG----------------------------QALTRLENNSRATRVLRVRDA---GLYTC 2277
Query: 536 IASNKVGTVGRNISFYITDVPN-------GFHVNLEKMPTEGEDLKLSCTVNKFLYRDVT 588
+A + G + ++ + PN F V L L L C+V +T
Sbjct: 2278 LAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAP-----GQLVLECSVEAEPAPKIT 2332
Query: 589 WILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEIL 648
W I Q+ A T+ L + +S DSG Y+C ARN +
Sbjct: 2333 W----------HRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVA 2382
Query: 649 QKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKN 697
+ EI P + V+++ + L C A+GVP P ++W K+
Sbjct: 2383 FRVEI----HTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKD 2427
Score = 80.5 bits (197), Expect = 5e-15
Identities = 86/371 (23%), Positives = 134/371 (36%), Gaps = 65/371 (17%)
Query: 344 LETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTR-GYSLIIKDVTEEDAGN 402
L T G ++ L K + P P + W KDG P + ++ + L++K++ +DAG
Sbjct: 2765 LSTTEGSHAF-LPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGT 2823
Query: 403 YTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQP 462
YT + + T++V ++ P LG R L C A G P P
Sbjct: 2824 YTCTAENAVGRARRRVHLTILVL-------PVFTTLPGDRSLRLGDRLWLRCAARGSPTP 2876
Query: 463 TIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTL 522
I W + +R +T+ ++ +G + +
Sbjct: 2877 RIGW------------------------------TVNDR--PVTEGVSEQDGGSTLQRAA 2904
Query: 523 VVADSRISGIYICIASNKVGTVGRNISFYITDVP----NGFHVNLEKMPTEGEDLKLSCT 578
V + SG Y+C A N+VG ++ + P F +E + G ++L C
Sbjct: 2905 VSRED--SGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPV---GGSIQLDCV 2959
Query: 579 VNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRA 638
V D+ WI + R H Q + LTI D+G Y C A
Sbjct: 2960 VRGDPVPDIHWIK-DGLPLRGSHLRHQLQNGS----------LTIRRTERDDAGRYQCLA 3008
Query: 639 RNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNN 698
N E + KK + + Q AP D TV L C A G P P I W +
Sbjct: 3009 EN----EMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAG 3064
Query: 699 HKIQQEPELYT 709
++ L T
Sbjct: 3065 QPLRASRRLRT 3075
Score = 77.4 bits (189), Expect = 4e-14
Identities = 99/426 (23%), Positives = 170/426 (39%), Gaps = 69/426 (16%)
Query: 296 LTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSY 353
L I + Q DKGLY+C+V + G + ++ +V + T ++ K + + VAG
Sbjct: 1806 LEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPP----TFENPKTETVSQVAGSPLV 1861
Query: 354 RLSMKVKAFPSPEVVWLKDGLPATEKSAR-YLTRGYSLIIKDVTEEDAGNYTILLSIKQS 412
L+ V P+P V WLKD +P + ++RG L + + AG YT + Q+
Sbjct: 1862 -LTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQA 1920
Query: 413 NVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQI-LTCTAYGIPQPTIKWFWHPC 471
K+ ++V P+I V+ + L +++ L C A G P P + W
Sbjct: 1921 EARKDFVVAVLV--APRIRSSGVAR----EHHVLEGQEVRLDCEADGQPPPDVAWL---- 1970
Query: 472 NHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISG 531
++ L D MG + ++G + + L +D+ G
Sbjct: 1971 ---------------KDGSPLGQD--MGPHLRFY------LDGGSLVLKGLRASDA---G 2004
Query: 532 IYICIASNKVGTVGRNISFYITDVPN---GFHVNLEKMPTEGEDLKLSCTVNKFLYRDVT 588
Y C+A N G R + + P G + + GE + + C V V+
Sbjct: 2005 AYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVS 2064
Query: 589 WILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEIL 648
W+ + +S++ + H+ L I V L D+G + C V +
Sbjct: 2065 WL------KDGLPLPLSQRTLLHGSGHT----LRISKVQLADAGIFTC----VAASPAGV 2110
Query: 649 QKKEITIRDQEAPYL--LRNLSDHTVAISSSTTLDCHANGVPEPQITWFKN-----NHKI 701
+ T++ Q P L + +D V S L C A GVP P ++W K+ + +
Sbjct: 2111 ADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSL 2170
Query: 702 QQEPEL 707
+Q P L
Sbjct: 2171 EQGPSL 2176
Score = 77.0 bits (188), Expect = 6e-14
Identities = 80/360 (22%), Positives = 138/360 (38%), Gaps = 59/360 (16%)
Query: 352 SYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRG-YSLIIKDVTEEDAGNYTILLSIK 410
S L V A P+PEV W KD + +L G ++L + D+G YT
Sbjct: 1672 SVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNA 1731
Query: 411 QSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHP 470
K + +++V P + +A D L +G + +L+C +P+PT+ W+
Sbjct: 1732 AGRDQKLVQLSVLV---PPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWY--- 1785
Query: 471 CNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS 530
+ + +L QR + G + L + ++++S
Sbjct: 1786 --------------KDGQPLVL-------------AQRTQALRGGQR----LEIQEAQVS 1814
Query: 531 --GIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMP-TEGEDLKLSCTVNKFLYRDV 587
G+Y C SN G R + + P + E + G L L+C V+ V
Sbjct: 1815 DKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTV 1874
Query: 588 TWILLRT-VNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEE 646
TW+ R V + +H +S+ L + + +GTY C A N +
Sbjct: 1875 TWLKDRMPVESSAVHGVVSRGG-----------RLQLSRLQPAQAGTYTCVAENT----Q 1919
Query: 647 ILQKKEITIRDQEAPYLLRN--LSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE 704
+K+ + AP + + +H V LDC A+G P P + W K+ + Q+
Sbjct: 1920 AEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQD 1979
Score = 77.0 bits (188), Expect = 6e-14
Identities = 140/654 (21%), Positives = 248/654 (37%), Gaps = 111/654 (16%)
Query: 69 KESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFI 128
K+S+ LS+ + G TL L A+ + +G Y+C+ L +K + ++ +
Sbjct: 1691 KDSQALSLGEEVFLLPGTH---TLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLV-- 1745
Query: 129 SDTGRPFVEMYSEIPE-IIHMTEGRELVIPCRVTS-PNITVTLKKFPLDTLIPDGKRIIW 186
P P+ + + G + V+ C + P TVT K DG+ ++
Sbjct: 1746 ----PPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYK--------DGQPLVL 1793
Query: 187 DSRKGFI-------ISNATYKEIGLLTCEAT-VNGHLYKTNYLTHRQTNTIIDVQISTPR 238
R + I A + GL +C+ + V G +T LT + T + + T
Sbjct: 1794 AQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTET-- 1851
Query: 239 PVKLLRGHTLVLNCTAT-TPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLT 297
V + G LVL C + P T +TW + ++V + + L
Sbjct: 1852 -VSQVAGSPLVLTCDVSGVPAPT---VTWLKDRMPVESSAVHGVVSRGGR--------LQ 1899
Query: 298 IDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
+ ++Q G YTC + + K +V + + + R+ VLE + RL
Sbjct: 1900 LSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEG----QEVRL 1955
Query: 356 SMKVKAFPSPEVVWLKDGLPATEKSA---RYLTRGYSLIIKDVTEEDAGNYTILLSIKQS 412
+ P P+V WLKDG P + R+ G SL++K + DAG YT +
Sbjct: 1956 DCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAG 2015
Query: 413 NVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCN 472
+ T ++ V P I + A S + G + C G P + W
Sbjct: 2016 EDARLHTVNVL--VPPTIKQGADGS--GTLVSRPGELVTMVCPVRGSPPIHVSWL----- 2066
Query: 473 HNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAII-EGKNKMASTLVVADSRISG 531
++ L ++QR + G S + +AD +G
Sbjct: 2067 --------------KDGLPL-----------PLSQRTLLHGSGHTLRISKVQLAD---AG 2098
Query: 532 IYICIASNKVGTVGRNISFYITDVPNGFHVNLEK--MPTEGEDLKLSCTVNKFLYRDVTW 589
I+ C+A++ G RN + + P V + + G ++L C V+W
Sbjct: 2099 IFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSW 2158
Query: 590 ILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQ 649
+ + ++ + E +L L V DSGTY+C A V E +
Sbjct: 2159 M------------KDGEPLLSQSLEQGPSLQLEA--VGAGDSGTYSCVA--VSEAGEARR 2202
Query: 650 KKEITIRDQEAPYLLRNLSDHTVAISSSTTLD--CHANGVPEPQITWFKNNHKI 701
++T+ E P++ + ++++ ++ C A G P+P ITW K+ +
Sbjct: 2203 HFQLTV--MEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL 2254
Score = 76.6 bits (187), Expect = 7e-14
Identities = 97/426 (22%), Positives = 160/426 (37%), Gaps = 75/426 (17%)
Query: 288 HANIFYSVLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLE 345
H + +L + + Q +G YTC + G S + + VH+ + R+
Sbjct: 930 HVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQI---AGPREPPTQV 986
Query: 346 TVAGKRSYRLSMKVKAFPSPEVVWLKDGLPA-TEKSARYLTRGYSLIIKDVTEEDAGNYT 404
+V L P P V W +DG P E + +G SL ++ G Y+
Sbjct: 987 SVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYS 1046
Query: 405 ILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALY---PLGSRQILTCTAYGIPQ 461
+ + +++V P++ DP L S L C A GIP
Sbjct: 1047 CVAENLAGRAERKFELSVLV--PPELIGDL-----DPLTNITAALHSPLTLLCEAMGIPP 1099
Query: 462 PTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMAST 521
P I+WF + S E++++L G + +TQ
Sbjct: 1100 PAIRWFRGE----------EPVSPGEDTYLL-----AGGWMLKMTQ-------------- 1130
Query: 522 LVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKM--PTEGEDLKLSCTV 579
+ SG+Y C+ASN+ G RN S + P+ + +LE++ +G+ L C V
Sbjct: 1131 ---TQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNV 1187
Query: 580 NKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSIT---LNLTIMNVSLQDSGTYAC 636
+TW + +A H I+ + L ++ +L +G Y+C
Sbjct: 1188 TGHPQPKLTWFK-------------DGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSC 1234
Query: 637 RARNVYTGEEILQKKEITIRDQEAPYLLRNLSDH-----TVAISSSTTLDCHANGVPEPQ 691
A N GE + K + AP +L D TV +++ +L C A P P
Sbjct: 1235 IAANA-VGE---KTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPN 1290
Query: 692 ITWFKN 697
ITW K+
Sbjct: 1291 ITWMKD 1296
Score = 74.7 bits (182), Expect = 3e-13
Identities = 145/648 (22%), Positives = 231/648 (35%), Gaps = 115/648 (17%)
Query: 94 LNTAQAN--HTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEG 151
L QAN G YSC +A +K + + ++ T E ++ E + +T
Sbjct: 1219 LQVLQANLSSAGHYSC--IAANAVGEKTKHFQLSVLLAPTILGGAEDSAD--EEVTVTVN 1274
Query: 152 RELVIPCRVT---SPNITVTLKKFPLDTLIPDGKRI-IWDSRKGFIISNATYKEIGLLTC 207
+ + C SPNIT P + + I + G I NA ++ G TC
Sbjct: 1275 NPISLICEALAFPSPNITWMKDGAPFEA----SRNIQLLPGTHGLQILNAQKEDAGQYTC 1330
Query: 208 EATVNGHLYKTNYLTHRQTNTIIDVQISTPRP--------VKLLRGHTLVLNCT--ATTP 257
T NY +I IS P VK TL L C A P
Sbjct: 1331 VVTNELGEAVKNY----HVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPP 1386
Query: 258 LNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS-- 315
R W Y D + S R ++ +L I Q D G Y C +
Sbjct: 1387 PTIR----W-YKDGQPVTPSSRLQVLGEGR-------LLQIQPTQVSDSGRYLCVATNVA 1434
Query: 316 GPSFKSVNTSVHI---------YDKAFITVKHRKQ------QVLETVAGKRSYRLSMKVK 360
G + N + + + AF + ++ + E V +Y L
Sbjct: 1435 GEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAY-LYCDTN 1493
Query: 361 AFPSPEVVWLKDGLPATE-KSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSN-VFKNL 418
A P P++ W ++ P + L G L I V E+AG Y S K SN V ++
Sbjct: 1494 AIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRY----SCKASNEVGEDW 1549
Query: 419 TATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEA 478
++ + P + + S L C A G P PTI W
Sbjct: 1550 LHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWL----------- 1598
Query: 479 RCDFCSNNEESFILDADSNMGNRIESITQRMAIIE-GKNKMASTLVVADSRISGIYICIA 537
N F S + R+ ++E G+ ST VAD+ Y+C+A
Sbjct: 1599 ------QNGLPF-------------SPSPRLQVLEDGQVLQVSTAEVADA---ASYMCVA 1636
Query: 538 SNKVGTVGRNISFYITDVPNGFHVNLEKMPTE-GEDLKLSCTVNKFLYRDVTWILLRTVN 596
N+ G+ + + + P ++LE++ + L C V+ +VTW
Sbjct: 1637 ENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWY------ 1690
Query: 597 NRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIR 656
+ S+ ++ + H++ L L DSG Y C A N ++ L + + +
Sbjct: 1691 KDSQALSLGEEVFLLPGTHTLQLG----RARLSDSGMYTCEALNAAGRDQKLVQLSVLVP 1746
Query: 657 D--QEAPYLLRNLSDHT-VAISSSTTLDCHANGVPEPQITWFKNNHKI 701
++AP R D V + L C + +PEP +TW+K+ +
Sbjct: 1747 PAFRQAP---RGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPL 1791
Score = 72.8 bits (177), Expect = 1e-12
Identities = 101/416 (24%), Positives = 147/416 (35%), Gaps = 66/416 (15%)
Query: 296 LTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSY 353
L I+K+ +D+G+YTC + G S + V K + V + V S
Sbjct: 568 LQIEKVDLRDEGIYTCAATNLAGESKREVAL------KVLVPPNIEPGPVNKAVLENASV 621
Query: 354 RLSMKVKAFPSPEVVWLKDGLPATE-KSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQS 412
L P P+V W K P + G L I+ DAG+Y + S
Sbjct: 622 TLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAG 681
Query: 413 NVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCN 472
+ L L VNV P+I S P P L R LTC A G P PT+ W
Sbjct: 682 ST--ELRYGLRVNVPPRI--TLPPSLPGPVLVNTPVR--LTCNATGAPSPTLMWL----- 730
Query: 473 HNHSEARCDFCSNNEESFILDADSNMGNRIESI-TQRMAIIEGKNKMASTLVVADSRISG 531
GN + T + + G + TL A + SG
Sbjct: 731 ------------------------KDGNPVSPAGTPGLQVFPGGRVL--TLASARASDSG 764
Query: 532 IYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWIL 591
Y C+A + VG +++ + P+ L E + L C + ++W
Sbjct: 765 RYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWK 824
Query: 592 L-RTVNNRT-MHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQ 649
R + R +H S K + + + + D+G Y C A N E
Sbjct: 825 DGRPLEPRPGVHLSADKALLQVDR------------ADVWDAGHYTCEALNQAGHSE--- 869
Query: 650 KKEITIRDQEAP-YLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE 704
K + AP + LR TV T L C GVP P+I+W K+ + E
Sbjct: 870 -KHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGE 924
Score = 72.8 bits (177), Expect = 1e-12
Identities = 84/324 (25%), Positives = 126/324 (38%), Gaps = 37/324 (11%)
Query: 149 TEGRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTC 207
TEG +PC+ SP +T K +GK I S + ++ N ++ G TC
Sbjct: 2768 TEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE-LLVKNLEGQDAGTYTC 2826
Query: 208 EA-TVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTW 266
A G + +LT ++ V + P L G L L C A R+ T
Sbjct: 2827 TAENAVGRARRRVHLTI----LVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT- 2881
Query: 267 SYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSV 326
N R +Q S L + +D G Y C + + V
Sbjct: 2882 -----VNDRPVTEGVSEQDGG------STLQRAAVSREDSGTYVCWAENRVGRTQAVSFV 2930
Query: 327 HIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTR 386
H+ + A + ++E V G S +L V+ P P++ W+KDGLP R+ +
Sbjct: 2931 HVKE-APVLQGEAFSYLVEPVGG--SIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQ 2987
Query: 387 GYSLIIKDVTEEDAGNYTIL----LSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPA 442
SL I+ +DAG Y L + + + V L + + V+PQ + V S D A
Sbjct: 2988 NGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQ--DMTVRSGDDVA 3045
Query: 443 LYPLGSRQILTCTAYGIPQPTIKW 466
L C A G P PTI+W
Sbjct: 3046 ---------LRCQATGEPTPTIEW 3060
Score = 71.6 bits (174), Expect = 2e-12
Identities = 141/688 (20%), Positives = 244/688 (35%), Gaps = 130/688 (18%)
Query: 42 IMQAGQTLHLQCRGEAAHKWSLPEMVS---KESERLSITKSACGRNGKQFCSTLTLNTAQ 98
+++ G L C +A LPE K+ + L + + G Q L + AQ
Sbjct: 1761 LVRVGDKAVLSCETDA-----LPEPTVTWYKDGQPLVLAQRTQALRGGQ---RLEIQEAQ 1812
Query: 99 ANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPC 158
+ G YSCK V + + + P E + E + G LV+ C
Sbjct: 1813 VSDKGLYSCKVSNVAGEAVRTFTLTVQV------PPTFE--NPKTETVSQVAGSPLVLTC 1864
Query: 159 RVT---SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFI-ISNATYKEIGLLTCEATVNGH 214
V+ +P +T + P+++ G SR G + +S + G TC A
Sbjct: 1865 DVSGVPAPTVTWLKDRMPVESSAVHGVV----SRGGRLQLSRLQPAQAGTYTCVAE---- 1916
Query: 215 LYKTNYLTHRQTNTIIDVQIS-------TPRPVKLLRGHTLVLNCTAT-TPLNTRVQMTW 266
N + + ++ V ++ R +L G + L+C A P +
Sbjct: 1917 ----NTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKD 1972
Query: 267 SYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSV 326
P ++ +R +D + L + ++ D G YTC V P+ + +
Sbjct: 1973 GSPLGQDMGPHLRFYLDGGS---------LVLKGLRASDAGAYTC-VAHNPAGEDAR--L 2020
Query: 327 HIYDKAFITVKHRKQQVLETVAGKRSYRLSM--KVKAFPSPEVVWLKDGLPATEKSARYL 384
H + + T+ + ++M V+ P V WLKDGLP L
Sbjct: 2021 HTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLL 2080
Query: 385 T-RGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPAL 443
G++L I V DAG +T + + +N T + V P + E F + +
Sbjct: 2081 HGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQV---PPVLEPV--EFQNDVV 2135
Query: 444 YPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIE 503
GS L C A G+P P + W + D + + +E
Sbjct: 2136 VVRGSLVELPCEARGVPLPLVSW------------------------MKDGEPLLSQSLE 2171
Query: 504 SITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNL 563
+G + + DS G Y C+A ++ G R+ + + P H+
Sbjct: 2172 ---------QGPSLQLEAVGAGDS---GTYSCVAVSEAGEARRHFQLTVMEPP---HIED 2216
Query: 564 EKMPTE-----GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSIT 618
PTE G ++L C ++TW K A+T+ + +
Sbjct: 2217 SGQPTELSLTPGAPMELLCDAQGTPQPNITW---------------HKDGQALTRLENNS 2261
Query: 619 LNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVA--ISS 676
++ V +D+G Y C A + E K +R Q P ++ V
Sbjct: 2262 RATRVLRV--RDAGLYTCLAESPAGAIE----KSFRVRVQAPPNIVGPRGPRFVVGLAPG 2315
Query: 677 STTLDCHANGVPEPQITWFKNNHKIQQE 704
L+C P P+ITW ++ +Q++
Sbjct: 2316 QLVLECSVEAEPAPKITWHRDGIVLQED 2343
Score = 67.0 bits (162), Expect = 6e-11
Identities = 120/560 (21%), Positives = 207/560 (36%), Gaps = 88/560 (15%)
Query: 160 VTSPNITVTLKKFPLDTLIPDGKRIIWD-SRKGFIISNATYKEIGLLTCEATVNGHLYKT 218
V +PNIT F L+P ++++ + + A + G+ TC+A+
Sbjct: 247 VPTPNITW----FKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKAS-------- 294
Query: 219 NYLTHRQTNTIIDVQI--------STPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPD 270
N + + T +DV + P VK + G + L C A T S+
Sbjct: 295 NAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVA----RGHPSPTLSWHH 350
Query: 271 EKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSV-NTSVHIY 329
E A + + S SVL ++ GLY+C V S P+ ++V SV +
Sbjct: 351 EGLPVA------ESNESRLETDGSVLRLESPGEASSGLYSC-VASSPAGEAVLQYSVEVQ 403
Query: 330 DKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSA-RYLTRGY 388
+ V QV T+ G+ L + P P + WL++G PA E + + ++G
Sbjct: 404 VPPQLLVAEGLGQVT-TIVGQ-PLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGT 461
Query: 389 SLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGS 448
+L I V + +G L + + +N A + V+V + P P+G
Sbjct: 462 TLHIDHVELDHSG----LFACQATNEAGTAGAEVEVSVHGEWA-------PGVLEVPIG- 509
Query: 449 RQILTCTAYGIPQPTIKWFWHPCNHNHSEARCD-----FCSNNEESFILDADSNMGNRIE 503
++ W +H+ A CD + + +++ + G
Sbjct: 510 ----------------QYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPG---- 549
Query: 504 SITQRMAIIEGKNKMASTLVV--ADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHV 561
S+ I + L + D R GIY C A+N G R ++ + PN
Sbjct: 550 SLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPG 609
Query: 562 NLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNL 621
+ K E + L C + DV+W + M ++S L
Sbjct: 610 PVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRV----------L 659
Query: 622 TIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLD 681
I L D+G+Y C A NV E+ + + + L V +++ L
Sbjct: 660 RIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPR---ITLPPSLPGPVLVNTPVRLT 716
Query: 682 CHANGVPEPQITWFKNNHKI 701
C+A G P P + W K+ + +
Sbjct: 717 CNATGAPSPTLMWLKDGNPV 736
Score = 62.8 bits (151), Expect = 1e-09
Identities = 96/447 (21%), Positives = 169/447 (37%), Gaps = 92/447 (20%)
Query: 296 LTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDK-------AFITVKHRKQQVLET 346
L I Q +D G YTC V + G + K+ + V I A + VK K +V T
Sbjct: 1315 LQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNST 1374
Query: 347 VAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSA-RYLTRGYSLIIKDVTEEDAGNYTI 405
+ L + A P P + W KDG P T S + L G L I+ D+G Y
Sbjct: 1375 LT------LECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLC 1428
Query: 406 LLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQ--------------- 450
+ + ++ + V P +++K V F A + + SR+
Sbjct: 1429 VATNVAGEDDQDFNVLIQV---PPMFQK-VGDFS--AAFEILSREEEARGGVTEYREIVE 1482
Query: 451 ----ILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESIT 506
L C IP P + W+ D + G+ +
Sbjct: 1483 NNPAYLYCDTNAIPPPDLTWYRE-----------------------DQPLSAGDEV---- 1515
Query: 507 QRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVP----NGFHVN 562
++++G + LV A++ +G Y C ASN+VG + + P + +
Sbjct: 1516 ---SVLQGGRVLQIPLVRAEN--AGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELV 1570
Query: 563 LEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLT 622
E + L C ++W+ + +S S ++ + ++ + L
Sbjct: 1571 EEVTVNASSTVSLQCPALGNPVPTISWL------QNGLPFSPSP-RLQVLEDGQV---LQ 1620
Query: 623 IMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLR-NLSDHTVAISSSTTLD 681
+ + D+ +Y C A N E K T+R Q P + +L T ++SS +L
Sbjct: 1621 VSTAEVADAASYMCVAENQAGSAE----KLFTLRVQVPPRIAGLDLEQVTAILNSSVSLP 1676
Query: 682 CHANGVPEPQITWFKNNHKIQQEPELY 708
C + P P++TW+K++ + E++
Sbjct: 1677 CDVHAHPNPEVTWYKDSQALSLGEEVF 1703
Score = 60.1 bits (144), Expect = 7e-09
Identities = 130/612 (21%), Positives = 208/612 (33%), Gaps = 91/612 (14%)
Query: 91 TLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTE 150
+L L A +G YSC V S+ E + + + P +E + P + +T
Sbjct: 2175 SLQLEAVGAGDSGTYSC----VAVSEAGEARRHFQLTVMEP--PHIEDSGQ-PTELSLTP 2227
Query: 151 GRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEA 209
G + + C +P +T K DG+ + ++ GL TC A
Sbjct: 2228 GAPMELLCDAQGTPQPNITWHK--------DGQALTRLENNSRATRVLRVRDAGLYTCLA 2279
Query: 210 TVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYP 269
+ ++ Q I V PR V L LVL C+ ++ TW
Sbjct: 2280 ESPAGAIEKSFRVRVQAPPNI-VGPRGPRFVVGLAPGQLVLECSVEAEPAPKI--TWH-- 2334
Query: 270 DEKNKRASVRRRIDQSNSHANIFYS--VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVH 327
R + + Q ++H L + + D G Y+C R+ SV V
Sbjct: 2335 -----RDGI---VLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVE 2386
Query: 328 IYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARY--LT 385
I+ I R V+ ++ L + P+P V W KD +P +S R+ L
Sbjct: 2387 IHTVPTI----RSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILP 2442
Query: 386 RGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYP 445
G SL I+ V +DAG+Y L S + + + + A++ P
Sbjct: 2443 EG-SLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRV-------LEPPAIAPSPSNLTLT 2494
Query: 446 LGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESI 505
+ +L C A G P+P + W+ + DF R++
Sbjct: 2495 AHTPALLPCEASGSPKPLVVWW-------KDGQKLDF------------------RLQQG 2529
Query: 506 TQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEK 565
R+ A L + S + C+ SN+VG R + P +
Sbjct: 2530 AYRLL-----PSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDF 2584
Query: 566 MPTEGEDLKLSCTVNKFLYRDVTWILL-RTVNNRTMHYSISKQKMAITKEHSITLNLTIM 624
T + L+C V+W + R Y +S L I
Sbjct: 2585 TVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGA-----------LEIG 2633
Query: 625 NVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHA 684
+G Y C ARN + K + + Q +P + S L C A
Sbjct: 2634 QALPIHAGRYTCSARN----SAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEA 2689
Query: 685 NGVPEPQITWFK 696
+G+P P ITW K
Sbjct: 2690 SGIPRPTITWQK 2701
Score = 59.7 bits (143), Expect = 9e-09
Identities = 76/354 (21%), Positives = 129/354 (36%), Gaps = 65/354 (18%)
Query: 355 LSMKVKAFPSPEVVWLKDGLPAT---EKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQ 411
L + P P VVW KDG ++ A L +L++ +D+ + ++S +
Sbjct: 2501 LPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEV 2560
Query: 412 SNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPC 471
+ T V+V P I + + F + P+ +LTC + GIP PT+ W
Sbjct: 2561 GEAHRLYQVT--VHVPPTIADDQ-TDFTVTMMAPV----VLTCHSTGIPAPTVSW----- 2608
Query: 472 NHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISG 531
S+A + G R+ G ++ L + +G
Sbjct: 2609 ----SKAGAQLGARGS-----------GYRVSP--------SGALEIGQALPIH----AG 2641
Query: 532 IYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWIL 591
Y C A N G +++ + P + E++ L C + +TW
Sbjct: 2642 RYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITW-- 2699
Query: 592 LRTVNNRTMHYSISKQKMAITKEHSITL----NLTIMNVSLQDSGTYACRARNVYTGEEI 647
K+ + + S + L I + S +D+G Y C A+N +
Sbjct: 2700 -------------QKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKN--SAGSA 2744
Query: 648 LQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKI 701
+ K + + Q P + L D + S L C A G PEP ITW K+ +
Sbjct: 2745 MGKTRLVV--QVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPV 2796
Score = 58.5 bits (140), Expect = 2e-08
Identities = 112/564 (19%), Positives = 207/564 (36%), Gaps = 106/564 (18%)
Query: 92 LTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEG 151
L + A H G Y+C +++ + ++F++ P V+ +P ++
Sbjct: 2630 LEIGQALPIHAGRYTC------SARNSAGVAHKHVFLTVQASPVVK---PLPSVVRAVAE 2680
Query: 152 RELVIPCRVTS-PNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEA- 209
E+++PC + P T+T +K L+ +++ + I++A+ ++ G C A
Sbjct: 2681 EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQ--LRIAHASPEDAGNYLCIAK 2738
Query: 210 -TVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSY 268
+ + KT + Q +I+ + + G L C A + +TW
Sbjct: 2739 NSAGSAMGKTRLVV--QVPPVIENGLPD---LSTTEGSHAFLPCKARG--SPEPNITWDK 2791
Query: 269 PDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSV 326
+ A + I S L + ++ +D G YTC + G + + V+ ++
Sbjct: 2792 DGQPVSGAEGKFTIQPSGE--------LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTI 2843
Query: 327 HIYDKAFITVKHRKQQVLETVAGKRSYRLSMKV------KAFPSPEVVWLKDGLPATEKS 380
+ V T+ G RS RL ++ + P+P + W + P TE
Sbjct: 2844 LVLP------------VFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV 2891
Query: 381 ARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVK--PQIYEKAVSSF 438
+ G +L V+ ED+G Y N A V+VK P + +A S
Sbjct: 2892 SEQ-DGGSTLQRAAVSREDSGTYVCWAE----NRVGRTQAVSFVHVKEAPVLQGEAFSYL 2946
Query: 439 PDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNM 498
+P +G L C G P P I W I D
Sbjct: 2947 VEP----VGGSIQLDCVVRGDPVPDIHW------------------------IKDGLPLR 2978
Query: 499 GNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNG 558
G+ + Q ++ T+ + +G Y C+A N++G + + + P
Sbjct: 2979 GSHLRHQLQNGSL---------TIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPV- 3028
Query: 559 FHVNLEKMPTE-GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSI 617
F V + M G+D+ L C + W+ + + +++ + S+
Sbjct: 3029 FQVEPQDMTVRSGDDVALRCQATGEPTPTIEWL-------QAGQPLRASRRLRTLPDGSL 3081
Query: 618 TLNLTIMNVSLQDSGTYACRARNV 641
L NV D+GTY C A N+
Sbjct: 3082 WLE----NVETGDAGTYDCVAHNL 3101
Score = 57.8 bits (138), Expect = 4e-08
Identities = 75/347 (21%), Positives = 121/347 (34%), Gaps = 65/347 (18%)
Query: 363 PSPEVVWLKDGLPATEKSARY-LTRGYSLIIKDVTEEDAGNYTILL----SIKQSNVFKN 417
P+P V W K G + + Y ++ +L I AG YT + +VF
Sbjct: 2602 PAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLT 2661
Query: 418 LTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSE 477
+ A+ +V P + +AV+ +L C A GIP+PTI W
Sbjct: 2662 VQASPVVKPLPSVV-RAVAE----------EEVLLPCEASGIPRPTITW----------- 2699
Query: 478 ARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIA 537
G + + + G+ ++A A +G Y+CIA
Sbjct: 2700 ------------------QKEGLNVATGVSTQVLPGGQLRIAH----ASPEDAGNYLCIA 2737
Query: 538 SNKVGTVGRNISFYITDVPNGFHVNLEKMPT-EGEDLKLSCTVNKFLYRDVTWILLRTVN 596
N G+ + VP L + T EG L C ++TW +
Sbjct: 2738 KNSAGSAMGKTRL-VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITW------D 2790
Query: 597 NRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIR 656
S ++ K I L + N+ QD+GTY C A N ++ + +
Sbjct: 2791 KDGQPVSGAEGKFTIQPSGE----LLVKNLEGQDAGTYTCTAENAVG----RARRRVHLT 2842
Query: 657 DQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQ 703
P D ++ + L C A G P P+I W N+ + +
Sbjct: 2843 ILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTE 2889
Score = 56.2 bits (134), Expect = 1e-07
Identities = 89/425 (20%), Positives = 153/425 (36%), Gaps = 67/425 (15%)
Query: 288 HANIFYSVLTIDKMQNKDKGLYTCRV--RSGPSFKSVNTSVHIYDKAFITVKHRKQQVLE 345
H + ++L +D+ D G YTC ++G S K N +V + + H
Sbjct: 836 HLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTL----- 890
Query: 346 TVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSA---RYLTRGYSLIIKDVTEEDAGN 402
TV RLS + + P P++ W KDG P + A G L + G
Sbjct: 891 TVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGT 950
Query: 403 YTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQP 462
YT S N ++L L V+V PQI P L C A G P P
Sbjct: 951 YTCECSNVVGNSSQDL--QLEVHVPPQI--AGPREPPTQVSVVQDGVATLECNATGKPPP 1006
Query: 463 TIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTL 522
T+ W E + +G ++++ Q + +
Sbjct: 1007 TVTW---------------------ERDGQPVGAELGLQLQNQGQSLHVER--------- 1036
Query: 523 VVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKF 582
A + +G Y C+A N G R F +++ P DL +
Sbjct: 1037 --AQAAHTGRYSCVAENLAGRAERK-----------FELSVLVPPELIGDLDPLTNITAA 1083
Query: 583 LYRDVTWIL-LRTVNNRTMHYSISKQKMAITKEHSITLN---LTIMNVSLQDSGTYACRA 638
L+ +T + + + + ++ ++ ++ + L + QDSG Y+C A
Sbjct: 1084 LHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLA 1143
Query: 639 RNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTT--LDCHANGVPEPQITWFK 696
N GE ++ ++ P + + + + T L C+ G P+P++TWFK
Sbjct: 1144 SN-EAGE---ARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFK 1199
Query: 697 NNHKI 701
+ +
Sbjct: 1200 DGRPL 1204
Score = 55.5 bits (132), Expect = 2e-07
Identities = 140/670 (20%), Positives = 237/670 (35%), Gaps = 132/670 (19%)
Query: 77 TKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFV 136
TK R G+Q L L AQ++ G Y+CK + +K T +Y+ P +
Sbjct: 265 TKVVYTRGGRQ----LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYV------PPTI 314
Query: 137 EMYSEIPEIIHMTEGRELVIPCRVTS-PNITVTLKKFPLDTLIPDGKRIIWDSRKGFIIS 195
E P ++ GR + + C P+ T++ L + R+ D +
Sbjct: 315 EGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSV-LRLE 373
Query: 196 NATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTAT 255
+ GL +C A+ Y Q + V + V + G L L C A+
Sbjct: 374 SPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQ-VTTIVGQPLELPCQAS 432
Query: 256 -TPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRV- 313
+P+ T + P E+ V + + L ID ++ GL+ C+
Sbjct: 433 GSPVPTIQWLQNGRPAEELAGVQVASQ-----------GTTLHIDHVELDHSGLFACQAT 481
Query: 314 -RSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK------------ 360
+G + V SVH VLE G+ +
Sbjct: 482 NEAGTAGAEVEVSVH---------GEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRG 532
Query: 361 --AFPSPEVV--WLKDGLPATEKSARYLTRGYSLI----IKDVTEEDAGNYTILLSIKQS 412
A P P +V W G E + + YSL I+ V D G YT +
Sbjct: 533 WGAHPKPPLVEGWCSPGSLWGEPTG--IPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAG 590
Query: 413 NVFKNLTATLIV--NVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHP 470
+ + ++V N++P KAV + L C A G+P P + WF
Sbjct: 591 ESKREVALKVLVPPNIEPGPVNKAVLE---------NASVTLECLASGVPPPDVSWF--- 638
Query: 471 CNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS 530
H S MG + S+ R+ IE A +
Sbjct: 639 --KGHQPV----------------SSWMGVTV-SVDGRVLRIEQ----------AQLSDA 669
Query: 531 GIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDL----------KLSCTVN 580
G Y C+ASN G+ T++ G VN+ T L +L+C
Sbjct: 670 GSYRCVASNVAGS---------TELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNAT 720
Query: 581 KFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
+ W L+ N + + Q + LT+ + DSG Y+C A +
Sbjct: 721 GAPSPTLMW--LKDGNPVSPAGTPGLQVFPGGRV------LTLASARASDSGRYSCVAVS 772
Query: 641 VYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHK 700
GE+ ++++ ++ P +L + +V + S L+C ++ +P P ++W+K+
Sbjct: 773 A-VGED---RQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRP 828
Query: 701 IQQEPELYTS 710
++ P ++ S
Sbjct: 829 LEPRPGVHLS 838
Score = 54.7 bits (130), Expect = 3e-07
Identities = 87/423 (20%), Positives = 153/423 (36%), Gaps = 65/423 (15%)
Query: 295 VLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRS 352
VLT+ + D G Y+C S G + V VH+ +++ +V S
Sbjct: 752 VLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSIL------GEELNVSVVANES 805
Query: 353 YRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEE-DAGNYTILLSIKQ 411
L + A P P + W KDG P + +L+ +L+ D + DAG+YT +
Sbjct: 806 VALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQA 865
Query: 412 SNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPC 471
+ K+ + V + E + + G L+C G+P P I W
Sbjct: 866 GHSEKHYNLNVWVAPVFPLRESHTLTVRE------GHPTRLSCECRGVPFPKISW----- 914
Query: 472 NHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISG 531
++ L + + ++ + + + G+ ++A G
Sbjct: 915 --------------RKDGQPLPGEGAGLQHVSAVGRLLYL--GQAQLAQ---------EG 949
Query: 532 IYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLK-----LSCTVNKFLYRD 586
Y C SN VG +++ + P + PT+ ++ L C
Sbjct: 950 TYTCECSNVVGNSSQDLQLEVHVPPQ--IAGPREPPTQVSVVQDGVATLECNATGKPPPT 1007
Query: 587 VTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEE 646
VTW + + Q ++ E + +G Y+C A N+ E
Sbjct: 1008 VTWERDGQPVGAELGLQLQNQGQSLHVERA----------QAAHTGRYSCVAENLAGRAE 1057
Query: 647 ILQKKEITIR-DQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEP 705
+K E+++ E L L++ T A+ S TL C A G+P P I WF+ +
Sbjct: 1058 --RKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGE 1115
Query: 706 ELY 708
+ Y
Sbjct: 1116 DTY 1118
Score = 53.9 bits (128), Expect = 5e-07
Identities = 123/614 (20%), Positives = 214/614 (34%), Gaps = 86/614 (14%)
Query: 91 TLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTE 150
+L L +A+ G Y+C + E A ++ P ++ ++ +
Sbjct: 1992 SLVLKGLRASDAGAYTC------VAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRP 2045
Query: 151 GRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEA 209
G + + C V SP I V+ K L + + ++ S IS + G+ TC A
Sbjct: 2046 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQ-RTLLHGSGHTLRISKVQLADAGIFTCVA 2104
Query: 210 TVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTAT-TPLNTRVQMTWSY 268
+ N+ Q +++ + V ++RG + L C A PL ++W
Sbjct: 2105 ASPAGVADRNFTLQVQVPPVLE-PVEFQNDVVVVRGSLVELPCEARGVPLPL---VSWM- 2159
Query: 269 PDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHI 328
K+ + + ++Q S L ++ + D G Y+C S + + +
Sbjct: 2160 ---KDGEPLLSQSLEQGPS--------LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTV 2208
Query: 329 YDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGY 388
+ I + ++ T L + P P + W KDG T
Sbjct: 2209 MEPPHIEDSGQPTELSLTPGAPME--LLCDAQGTPQPNITWHKDGQALTR------LENN 2260
Query: 389 SLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGS 448
S + + DAG YT L + K+ V P I F L P
Sbjct: 2261 SRATRVLRVRDAGLYTCLAESPAGAIEKSFRVR--VQAPPNIVGPRGPRFV-VGLAP--G 2315
Query: 449 RQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQR 508
+ +L C+ P P I W + + +L D++ +R
Sbjct: 2316 QLVLECSVEAEPAPKITW-------------------HRDGIVLQEDAHT-----QFPER 2351
Query: 509 MAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPT 568
G+ L ADS G Y C A N G+ I VP +
Sbjct: 2352 -----GRFLQLQALSTADS---GDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVS 2403
Query: 569 EGEDLKLSCTVNKFLYRDVTWILLRT-VNNRTMHYSISKQKMAITKEHSITLNLTIMNVS 627
+ L C + V+W R ++ R+ + I + +L I V
Sbjct: 2404 VNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEG-----------SLRIQPVL 2452
Query: 628 LQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGV 687
QD+G Y C A N + ++ +R E P + + S+ T+ + L C A+G
Sbjct: 2453 AQDAGHYLCLASNSAGSD----RQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGS 2508
Query: 688 PEPQITWFKNNHKI 701
P+P + W+K+ K+
Sbjct: 2509 PKPLVVWWKDGQKL 2522
Score = 52.4 bits (124), Expect = 2e-06
Identities = 93/378 (24%), Positives = 139/378 (36%), Gaps = 63/378 (16%)
Query: 295 VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYR 354
VL I D+G Y C S ++ + + ++ I + +V V +
Sbjct: 182 VLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEV--AVMEDHLVQ 239
Query: 355 LSMKVKAFPSPEVVWLKDG-LPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSN 413
L + + P+P + W KDG L T Y G L + DAG YT K SN
Sbjct: 240 LLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYT----CKASN 295
Query: 414 VF--KNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPC 471
L V V P I + P G L C A G P PT+ W
Sbjct: 296 AVGAAEKATRLDVYVPPTI--EGAGGRPYVVKAVAGRPVALECVARGHPSPTLSW----- 348
Query: 472 NHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISG 531
H E +NE L+ D ++ R+ES SG
Sbjct: 349 ---HHEG-LPVAESNESR--LETDGSV-LRLES--------------------PGEASSG 381
Query: 532 IYICIASNKVGTVGRNISFYITDVPNGFHV--NLEKMPT-EGEDLKLSCTVNKFLYRDVT 588
+Y C+AS+ G S + VP V L ++ T G+ L+L C + +
Sbjct: 382 LYSCVASSPAGEAVLQYSVEV-QVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQ 440
Query: 589 WILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNV--YTGEE 646
W+ N R +++A + S L I +V L SG +AC+A N G E
Sbjct: 441 WL----QNGR------PAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAE 490
Query: 647 ILQKKEITIRDQEAPYLL 664
+ E+++ + AP +L
Sbjct: 491 V----EVSVHGEWAPGVL 504
Score = 51.2 bits (121), Expect = 3e-06
Identities = 84/417 (20%), Positives = 147/417 (35%), Gaps = 91/417 (21%)
Query: 351 RSYRLSMKVKAFPSPEVVWLKD----GLP------------ATEKSARYLTRGYSLIIKD 394
+S L FP PE+VWLKD G+P R L G SL
Sbjct: 34 QSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPR 93
Query: 395 VTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTC 454
+ E D+G Y+ + ++ L+V P + + L G+ L C
Sbjct: 94 IQEGDSGLYSCRAENQAGTAQRDFH--LLVLTPPSVLGAGAAQ---EVLGLAGADVELQC 148
Query: 455 TAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEG 514
G+P P ++W + +L ++ + + R I G
Sbjct: 149 WTSGVPTPQVEW------------------TKDRQPVLPGGPHLQVQEDGQVLR---ITG 187
Query: 515 KNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPN--GFHVNLEKMPTEGED 572
+ V D G Y C+A + G R+ + P G + E E
Sbjct: 188 SH-------VGDE---GRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHL 237
Query: 573 LKLSCTVNKFLYRDVTWI----LLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSL 628
++L C ++TW LL T + + Y+ +++ + + S
Sbjct: 238 VQLLCEARGVPTPNITWFKDGALLPT--STKVVYTRGGRQLQLGRAQS------------ 283
Query: 629 QDSGTYACRARNVYTGEEILQKKEITIRDQ-----EAPYLLRNLSDHTVAISSSTTLDCH 683
D+G Y C+A N E + ++ + PY+++ ++ VA L+C
Sbjct: 284 SDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVA------LECV 337
Query: 684 ANGVPEPQITWF--------KNNHKIQQEPELYTSTSPSSSSSSPLSSSSSSSSSSS 732
A G P P ++W N +++ + + SP +SS S +SS + +
Sbjct: 338 ARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEA 394
Score = 49.7 bits (117), Expect = 1e-05
Identities = 86/415 (20%), Positives = 141/415 (33%), Gaps = 60/415 (14%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
L ++Q D GLY+CR + + + + + Q+VL +AG L
Sbjct: 89 LHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVL-GLAG-ADVEL 146
Query: 356 SMKVKAFPSPEVVWLKDGLPATEKSARYLTR--GYSLIIKDVTEEDAGNYTILLSIKQSN 413
P+P+V W KD P + G L I D G Y +
Sbjct: 147 QCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQ 206
Query: 414 VFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNH 473
++ L V+ P I+ + + A+ Q+L C A G+P P I WF
Sbjct: 207 QARDF--QLRVHAPPTIW--GSNETGEVAVMEDHLVQLL-CEARGVPTPNITWF------ 255
Query: 474 NHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIY 533
++ +L + ++ + L A S +G+Y
Sbjct: 256 -------------KDGALLPTSTK-------------VVYTRGGRQLQLGRAQSSDAGVY 289
Query: 534 ICIASNKVGTVGR--NISFYITDVPNGFHVN-LEKMPTEGEDLKLSCTVNKFLYRDVTWI 590
C ASN VG + + Y+ G G + L C ++W
Sbjct: 290 TCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSW- 348
Query: 591 LLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQK 650
H + + ++ + L + + SG Y+C A + GE +LQ
Sbjct: 349 ---------HHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSP-AGEAVLQ- 397
Query: 651 KEITIRDQEAPYLL--RNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQ 703
++ Q P LL L T + L C A+G P P I W +N ++
Sbjct: 398 --YSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEE 450
Score = 30.4 bits (67), Expect = 6.1
Identities = 34/137 (24%), Positives = 54/137 (39%), Gaps = 12/137 (8%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
LTI + + D G Y C + + + V+ + TV L
Sbjct: 2991 LTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDM----TVRSGDDVAL 3046
Query: 356 SMKVKAFPSPEVVWLKDGLP-ATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNV 414
+ P+P + WL+ G P + R L G SL +++V DAG Y + N+
Sbjct: 3047 RCQATGEPTPTIEWLQAGQPLRASRRLRTLPDG-SLWLENVETGDAGTYDCV----AHNL 3101
Query: 415 FKNLTAT--LIVNVKPQ 429
+ TA L+V +PQ
Sbjct: 3102 LGSATARAFLVVRGEPQ 3118
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 85.1 bits (209), Expect = 2e-16
Identities = 112/520 (21%), Positives = 193/520 (37%), Gaps = 76/520 (14%)
Query: 234 ISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSH----- 288
+ P V + +G LNC A ++ W E+ V D SH
Sbjct: 50 VEHPSDVIVSKGEPTTLNCKAEGRPTPTIE--WYKDGER-----VETDKDDPRSHRMLLP 102
Query: 289 -ANIFYSVLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQV-L 344
++F+ + + D+G Y C R+ G + S N S+ + A + R+ +
Sbjct: 103 SGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAV-SRNASLEV---ALLRDDFRQNPTDV 158
Query: 345 ETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYT 404
AG+ + + P P + W KD + +K R RG L+I + + DAG YT
Sbjct: 159 VVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYT 218
Query: 405 ILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQI-LTCTAYGIPQPT 463
+ + A L V +P + ++ L + C G PQPT
Sbjct: 219 CV-GTNMVGERDSDPAELTVFERPTFLRRPINQVV------LEEEAVEFRCQVQGDPQPT 271
Query: 464 IKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLV 523
++W + D DAD G + K+ +
Sbjct: 272 VRW------------KKD-----------DADLPRGR-----------YDIKDDYTLRIK 297
Query: 524 VADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFL 583
S G Y+CIA N+VG + + + + P +++ +G + C
Sbjct: 298 KTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNP 357
Query: 584 YRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYT 643
V W + ++ + + Q+ S T +LTI N+ D+G Y C+A V
Sbjct: 358 QPAVFW---QKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAG 414
Query: 644 GEEILQKKEIT--IRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNH-- 699
+ E+T + D+ P +L+ ++ T+A+ + L C A G P P I+W K
Sbjct: 415 SILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTF 474
Query: 700 -------KIQQEPELYTSTSPSSSSSSPLSSSSSSSSSSS 732
IQ++ L S + + ++SSS +S
Sbjct: 475 PGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETS 514
Score = 47.0 bits (110), Expect = 6e-05
Identities = 99/477 (20%), Positives = 163/477 (34%), Gaps = 74/477 (15%)
Query: 22 GSSSGSKLKDPELSLKGTQH----IMQAGQTLHLQCRGEAAHKWSLPEMVSKESERLSIT 77
G GS+L+ + + +H I+ G+ L C+ E ++ K+ ER+
Sbjct: 33 GQGQGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWY--KDGERVETD 90
Query: 78 KSACGRN------GKQFCSTLTLNTAQANHTGFYSC---KYLAVPTSKKKETESAIYIFI 128
K + G F + G Y C YL S+ E A+
Sbjct: 91 KDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVAL---- 146
Query: 129 SDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTS--PNITVTLKKFPLDTLIPDGKRIIW 186
+ + + P + + G ++ C+ P T+ KK D + D K
Sbjct: 147 ------LRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKK---DKVRIDDKEERI 197
Query: 187 DSRKG-FIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTN----TIIDVQISTPRPVK 241
R G +ISN + G+ TC T N + R ++ T+ + RP+
Sbjct: 198 SIRGGKLMISNTRKSDAGMYTCVGT--------NMVGERDSDPAELTVFERPTFLRRPIN 249
Query: 242 --LLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTID 299
+L + C V+ W D R R D + + L I
Sbjct: 250 QVVLEEEAVEFRCQVQGDPQPTVR--WKKDDADLPRG----RYDIKDDYT------LRIK 297
Query: 300 KMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKV 359
K + D+G Y C + + ++ + V+ R Q VA R+ +
Sbjct: 298 KTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQ----IVAQGRTVTFPCET 353
Query: 360 KAFPSPEVVWLKDG--------LPATEKSARYLTRGYSLIIKDVTEEDAGNYTI-LLSIK 410
K P P V W K+G P S ++ L I ++ DAG Y L++
Sbjct: 354 KGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVA 413
Query: 411 QSNVFK-NLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKW 466
S + K L T ++ +P + P + +L C A G P P I W
Sbjct: 414 GSILAKAQLEVTDVLTDRP---PPIILQGPANQTLAVDGTALLKCKATGDPLPVISW 467
Score = 42.7 bits (99), Expect = 0.001
Identities = 87/387 (22%), Positives = 147/387 (37%), Gaps = 60/387 (15%)
Query: 39 TQHIMQAGQTLHLQCRGEAAHK-----WSLPEM-VSKESERLSITKSACGRNGKQFCSTL 92
T ++ AG+ L+C+ H W ++ + + ER+SI R GK L
Sbjct: 156 TDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISI------RGGK-----L 204
Query: 93 TLNTAQANHTGFYSCKYLAVPTSKKKETES---AIYIFISDT--GRPFVEMYSEIPEIIH 147
++ + + G Y+C V T+ E +S + +F T RP ++
Sbjct: 205 MISNTRKSDAGMYTC----VGTNMVGERDSDPAELTVFERPTFLRRPINQV--------- 251
Query: 148 MTEGRELVIPCRVTS-PNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLT 206
+ E + C+V P TV KK D +P G+ I D I + E +
Sbjct: 252 VLEEEAVEFRCQVQGDPQPTVRWKKDDAD--LPRGRYDIKDDYTLRIKKTMSTDEGTYMC 309
Query: 207 CEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTW 266
G + + LT R + PR + +G T+ C T N + + W
Sbjct: 310 IAENRVGKMEASATLTVRAPPQFV----VRPRDQIVAQGRTVTFPCE--TKGNPQPAVFW 363
Query: 267 SYPDEKNKRASVRRRIDQSNSHANIFYSV-LTIDKMQNKDKGLYTCRVRSGPSFKSVNTS 325
E ++ + Q NS ++ + LTI +Q D G Y C+ +
Sbjct: 364 Q--KEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQ 421
Query: 326 VHIYDKAFITVKHRKQQVL------ETVAGKRSYRLSMKVKAFPSPEVVWLKDG--LPAT 377
+ + D + R ++ +T+A + L K P P + WLK+G P
Sbjct: 422 LEVTD----VLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGR 477
Query: 378 EKSARYLTRGYSLIIKDVTEEDAGNYT 404
+ A +G +L IK++ D G YT
Sbjct: 478 DPRATIQEQG-TLQIKNLRISDTGTYT 503
Score = 39.3 bits (90), Expect = 0.013
Identities = 19/59 (32%), Positives = 31/59 (52%), Gaps = 3/59 (5%)
Query: 661 PYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQ---QEPELYTSTSPSSS 716
P ++ + SD V+ TTL+C A G P P I W+K+ +++ +P + PS S
Sbjct: 47 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 105
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 85.1 bits (209), Expect = 2e-16
Identities = 112/520 (21%), Positives = 193/520 (37%), Gaps = 76/520 (14%)
Query: 234 ISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSH----- 288
+ P V + +G LNC A ++ W E+ V D SH
Sbjct: 34 VEHPSDVIVSKGEPTTLNCKAEGRPTPTIE--WYKDGER-----VETDKDDPRSHRMLLP 86
Query: 289 -ANIFYSVLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQV-L 344
++F+ + + D+G Y C R+ G + S N S+ + A + R+ +
Sbjct: 87 SGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAV-SRNASLEV---ALLRDDFRQNPTDV 142
Query: 345 ETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYT 404
AG+ + + P P + W KD + +K R RG L+I + + DAG YT
Sbjct: 143 VVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYT 202
Query: 405 ILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQI-LTCTAYGIPQPT 463
+ + A L V +P + ++ L + C G PQPT
Sbjct: 203 CV-GTNMVGERDSDPAELTVFERPTFLRRPINQVV------LEEEAVEFRCQVQGDPQPT 255
Query: 464 IKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLV 523
++W + D DAD G + K+ +
Sbjct: 256 VRW------------KKD-----------DADLPRGR-----------YDIKDDYTLRIK 281
Query: 524 VADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFL 583
S G Y+CIA N+VG + + + + P +++ +G + C
Sbjct: 282 KTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNP 341
Query: 584 YRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYT 643
V W + ++ + + Q+ S T +LTI N+ D+G Y C+A V
Sbjct: 342 QPAVFW---QKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAG 398
Query: 644 GEEILQKKEIT--IRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNH-- 699
+ E+T + D+ P +L+ ++ T+A+ + L C A G P P I+W K
Sbjct: 399 SILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTF 458
Query: 700 -------KIQQEPELYTSTSPSSSSSSPLSSSSSSSSSSS 732
IQ++ L S + + ++SSS +S
Sbjct: 459 PGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETS 498
Score = 47.8 bits (112), Expect = 4e-05
Identities = 102/490 (20%), Positives = 168/490 (34%), Gaps = 74/490 (15%)
Query: 9 VLLCALLSCLLLTGSSSGSKLKDPELSLKGTQH----IMQAGQTLHLQCRGEAAHKWSLP 64
++ LL C L GS+L+ + + +H I+ G+ L C+ E ++
Sbjct: 4 LMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIE 63
Query: 65 EMVSKESERLSITKSACGRN------GKQFCSTLTLNTAQANHTGFYSC---KYLAVPTS 115
K+ ER+ K + G F + G Y C YL S
Sbjct: 64 WY--KDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVS 121
Query: 116 KKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTS--PNITVTLKKFP 173
+ E A+ + + + P + + G ++ C+ P T+ KK
Sbjct: 122 RNASLEVAL----------LRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKK-- 169
Query: 174 LDTLIPDGKRIIWDSRKG-FIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTN----T 228
D + D K R G +ISN + G+ TC T N + R ++ T
Sbjct: 170 -DKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGT--------NMVGERDSDPAELT 220
Query: 229 IIDVQISTPRPVK--LLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSN 286
+ + RP+ +L + C V+ W D R R D +
Sbjct: 221 VFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVR--WKKDDADLPRG----RYDIKD 274
Query: 287 SHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLET 346
+ L I K + D+G Y C + + ++ + V+ R Q
Sbjct: 275 DYT------LRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQ----I 324
Query: 347 VAGKRSYRLSMKVKAFPSPEVVWLKDG--------LPATEKSARYLTRGYSLIIKDVTEE 398
VA R+ + K P P V W K+G P S ++ L I ++
Sbjct: 325 VAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRS 384
Query: 399 DAGNYTI-LLSIKQSNVFK-NLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTA 456
DAG Y L++ S + K L T ++ +P + P + +L C A
Sbjct: 385 DAGYYICQALTVAGSILAKAQLEVTDVLTDRP---PPIILQGPANQTLAVDGTALLKCKA 441
Query: 457 YGIPQPTIKW 466
G P P I W
Sbjct: 442 TGDPLPVISW 451
Score = 42.7 bits (99), Expect = 0.001
Identities = 87/387 (22%), Positives = 147/387 (37%), Gaps = 60/387 (15%)
Query: 39 TQHIMQAGQTLHLQCRGEAAHK-----WSLPEM-VSKESERLSITKSACGRNGKQFCSTL 92
T ++ AG+ L+C+ H W ++ + + ER+SI R GK L
Sbjct: 140 TDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISI------RGGK-----L 188
Query: 93 TLNTAQANHTGFYSCKYLAVPTSKKKETES---AIYIFISDT--GRPFVEMYSEIPEIIH 147
++ + + G Y+C V T+ E +S + +F T RP ++
Sbjct: 189 MISNTRKSDAGMYTC----VGTNMVGERDSDPAELTVFERPTFLRRPINQV--------- 235
Query: 148 MTEGRELVIPCRVTS-PNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLT 206
+ E + C+V P TV KK D +P G+ I D I + E +
Sbjct: 236 VLEEEAVEFRCQVQGDPQPTVRWKKDDAD--LPRGRYDIKDDYTLRIKKTMSTDEGTYMC 293
Query: 207 CEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTW 266
G + + LT R + PR + +G T+ C T N + + W
Sbjct: 294 IAENRVGKMEASATLTVRAPPQFV----VRPRDQIVAQGRTVTFPCE--TKGNPQPAVFW 347
Query: 267 SYPDEKNKRASVRRRIDQSNSHANIFYSV-LTIDKMQNKDKGLYTCRVRSGPSFKSVNTS 325
E ++ + Q NS ++ + LTI +Q D G Y C+ +
Sbjct: 348 Q--KEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQ 405
Query: 326 VHIYDKAFITVKHRKQQVL------ETVAGKRSYRLSMKVKAFPSPEVVWLKDG--LPAT 377
+ + D + R ++ +T+A + L K P P + WLK+G P
Sbjct: 406 LEVTD----VLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGR 461
Query: 378 EKSARYLTRGYSLIIKDVTEEDAGNYT 404
+ A +G +L IK++ D G YT
Sbjct: 462 DPRATIQEQG-TLQIKNLRISDTGTYT 487
Score = 39.3 bits (90), Expect = 0.013
Identities = 19/59 (32%), Positives = 31/59 (52%), Gaps = 3/59 (5%)
Query: 661 PYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQ---QEPELYTSTSPSSS 716
P ++ + SD V+ TTL+C A G P P I W+K+ +++ +P + PS S
Sbjct: 31 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 84.7 bits (208), Expect = 3e-16
Identities = 107/479 (22%), Positives = 178/479 (37%), Gaps = 73/479 (15%)
Query: 234 ISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSH----- 288
+ P + + +G LNC A ++ W E+ V D SH
Sbjct: 32 VEHPSDLIVSKGEPATLNCKAEGRPTPTIE--WYKGGER-----VETDKDDPRSHRMLLP 84
Query: 289 -ANIFYSVLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLE 345
++F+ + + D+G+Y C R+ G + S N S+ + A + R+
Sbjct: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEV---AILRDDFRQNPSDV 140
Query: 346 TVA-GKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNY- 403
VA G+ + + P P + W KDG P +K R RG L+I + DAG Y
Sbjct: 141 MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYV 200
Query: 404 ---TILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIP 460
T ++ ++S V A L V +P ++ P + C A G P
Sbjct: 201 CVGTNMVGERESEV-----AELTVLERPSFVKR-----PSNLAVTVDDSAEFKCEARGDP 250
Query: 461 QPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMAS 520
PT++W R D + + + D + +I +T
Sbjct: 251 VPTVRW------------RKDDGELPKSRYEIRDDHTL--KIRKVT-------------- 282
Query: 521 TLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVN 580
+ G Y C+A N VG + + + + P+ +++ G + C
Sbjct: 283 ------AGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEAT 336
Query: 581 KFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
+ W R ++ + +S + + S T +LTI NV D G Y C+ N
Sbjct: 337 GNPQPAIFW---RREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN 393
Query: 641 VYTGEEILQKKEIT--IRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKN 697
V E+T I D+ P + + + TVA+ + L C A G P P I W K+
Sbjct: 394 VAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKD 452
Score = 56.6 bits (135), Expect = 8e-08
Identities = 80/384 (20%), Positives = 136/384 (35%), Gaps = 74/384 (19%)
Query: 355 LSMKVKAFPSPEVVWLKDGLPA-TEK----SARYLTRGYSLIIKDV-----TEEDAGNYT 404
L+ K + P+P + W K G T+K S R L SL + + D G Y
Sbjct: 48 LNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYV 107
Query: 405 ILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTA-YGIPQPT 463
+ + + + ++ + P + +G ++ C G P+PT
Sbjct: 108 CVARNYLGEAVSHNASLEVAILRDDFRQN-----PSDVMVAVGEPAVMECQPPRGHPEPT 162
Query: 464 IKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLV 523
I W G+ ++ +R+ I GK L+
Sbjct: 163 ISW-----------------------------KKDGSPLDDKDERITIRGGK------LM 187
Query: 524 VADSRIS--GIYICIASNKVGTVGRNIS-FYITDVPNGFHVNLEKMPTEGEDLKLSCTVN 580
+ +R S G Y+C+ +N VG ++ + + P+ T + + C
Sbjct: 188 ITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEAR 247
Query: 581 KFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
V W R + K + I +H+ L I V+ D G+Y C A N
Sbjct: 248 GDPVPTVRW--------RKDDGELPKSRYEIRDDHT----LKIRKVTAGDMGSYTCVAEN 295
Query: 641 VYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHK 700
+ E T+ QE P+ + D VA+ + T C A G P+P I W +
Sbjct: 296 MVGKAEA----SATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREG-- 349
Query: 701 IQQEPELYTSTSPSSSSSSPLSSS 724
+ L++ P SSS +S +
Sbjct: 350 --SQNLLFSYQPPQSSSRFSVSQT 371
Score = 48.9 bits (115), Expect = 2e-05
Identities = 79/318 (24%), Positives = 124/318 (38%), Gaps = 43/318 (13%)
Query: 108 KYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITV 167
KY+ V T+ E ES + FV+ S + + + + E R P TV
Sbjct: 198 KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLA--VTVDDSAEFKCEAR-GDPVPTV 254
Query: 168 TLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTN 227
+K D +P + I D I T ++G TC A N + + +
Sbjct: 255 RWRKD--DGELPKSRYEIRDDHT-LKIRKVTAGDMGSYTCVAE--------NMVGKAEAS 303
Query: 228 TIIDVQ-----ISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRI 282
+ VQ + PR + G T+ C AT N + + W +N S +
Sbjct: 304 ATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATG--NPQPAIFWRREGSQNLLFSYQP-- 359
Query: 283 DQSNSHANIFYSV-LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKH--- 338
QS+S ++ + LTI +Q D G Y C+ ++N + I KA++ V
Sbjct: 360 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQ--------TLNVAGSIITKAYLEVTDVIA 411
Query: 339 -------RKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG-LPATEKSARYLTRGYSL 390
R+ V +TVA ++ LS P P ++W KDG L +T+ S L
Sbjct: 412 DRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVL 471
Query: 391 IIKDVTEEDAGNYTILLS 408
I+ D G YT + S
Sbjct: 472 QIRYAKLGDTGRYTCIAS 489
Score = 43.9 bits (102), Expect = 5e-04
Identities = 98/474 (20%), Positives = 162/474 (34%), Gaps = 74/474 (15%)
Query: 25 SGSKLKDPELSLKGTQH----IMQAGQTLHLQCRGEAAHKWSLPEMVSKESERLSITKSA 80
SGS+L+ + + +H I+ G+ L C+ E ++ K ER+ K
Sbjct: 18 SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWY--KGGERVETDKDD 75
Query: 81 CGRN------GKQFCSTLTLNTAQANHTGFYSC---KYLAVPTSKKKETESAIYIFISDT 131
+ G F + G Y C YL S E AI
Sbjct: 76 PRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI------- 128
Query: 132 GRPFVEMYSEIPEIIHMTEGRELVIPCRVTS--PNITVTLKK--FPLDT-----LIPDGK 182
+ + + P + + G V+ C+ P T++ KK PLD I GK
Sbjct: 129 ---LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK 185
Query: 183 RIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKL 242
+I +RK + G C T N + R++ + P VK
Sbjct: 186 LMITYTRKS---------DAGKYVCVGT--------NMVGERESEVAELTVLERPSFVKR 228
Query: 243 LRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQ 302
+ ++ +A R + K+ + R + + H L I K+
Sbjct: 229 PSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHT------LKIRKVT 282
Query: 303 NKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAF 362
D G YTC + + ++ + + VK R Q VA R+ +
Sbjct: 283 AGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ----VVALGRTVTFQCEATGN 338
Query: 363 PSPEVVWLKDGL--------PATEKSARYLTRGYSLIIKDVTEEDAGNYTI-LLSIKQSN 413
P P + W ++G P S +++ L I +V D G Y L++ S
Sbjct: 339 PQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSI 398
Query: 414 VFKN-LTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKW 466
+ K L T ++ +P + P + +L+C A G P PTI W
Sbjct: 399 ITKAYLEVTDVIADRPP---PVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW 449
Score = 37.0 bits (84), Expect = 0.065
Identities = 18/59 (30%), Positives = 29/59 (49%), Gaps = 3/59 (5%)
Query: 661 PYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQ---QEPELYTSTSPSSS 716
P ++ + SD V+ TL+C A G P P I W+K +++ +P + PS S
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 84.7 bits (208), Expect = 3e-16
Identities = 107/479 (22%), Positives = 178/479 (37%), Gaps = 73/479 (15%)
Query: 234 ISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSH----- 288
+ P + + +G LNC A ++ W E+ V D SH
Sbjct: 71 VEHPSDLIVSKGEPATLNCKAEGRPTPTIE--WYKGGER-----VETDKDDPRSHRMLLP 123
Query: 289 -ANIFYSVLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLE 345
++F+ + + D+G+Y C R+ G + S N S+ + A + R+
Sbjct: 124 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEV---AILRDDFRQNPSDV 179
Query: 346 TVA-GKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNY- 403
VA G+ + + P P + W KDG P +K R RG L+I + DAG Y
Sbjct: 180 MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYV 239
Query: 404 ---TILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIP 460
T ++ ++S V A L V +P ++ P + C A G P
Sbjct: 240 CVGTNMVGERESEV-----AELTVLERPSFVKR-----PSNLAVTVDDSAEFKCEARGDP 289
Query: 461 QPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMAS 520
PT++W R D + + + D + +I +T
Sbjct: 290 VPTVRW------------RKDDGELPKSRYEIRDDHTL--KIRKVT-------------- 321
Query: 521 TLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVN 580
+ G Y C+A N VG + + + + P+ +++ G + C
Sbjct: 322 ------AGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEAT 375
Query: 581 KFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
+ W R ++ + +S + + S T +LTI NV D G Y C+ N
Sbjct: 376 GNPQPAIFW---RREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN 432
Query: 641 VYTGEEILQKKEIT--IRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKN 697
V E+T I D+ P + + + TVA+ + L C A G P P I W K+
Sbjct: 433 VAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKD 491
Score = 56.6 bits (135), Expect = 8e-08
Identities = 80/384 (20%), Positives = 136/384 (35%), Gaps = 74/384 (19%)
Query: 355 LSMKVKAFPSPEVVWLKDGLPA-TEK----SARYLTRGYSLIIKDV-----TEEDAGNYT 404
L+ K + P+P + W K G T+K S R L SL + + D G Y
Sbjct: 87 LNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYV 146
Query: 405 ILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTA-YGIPQPT 463
+ + + + ++ + P + +G ++ C G P+PT
Sbjct: 147 CVARNYLGEAVSHNASLEVAILRDDFRQN-----PSDVMVAVGEPAVMECQPPRGHPEPT 201
Query: 464 IKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLV 523
I W G+ ++ +R+ I GK L+
Sbjct: 202 ISW-----------------------------KKDGSPLDDKDERITIRGGK------LM 226
Query: 524 VADSRIS--GIYICIASNKVGTVGRNIS-FYITDVPNGFHVNLEKMPTEGEDLKLSCTVN 580
+ +R S G Y+C+ +N VG ++ + + P+ T + + C
Sbjct: 227 ITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEAR 286
Query: 581 KFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
V W R + K + I +H+ L I V+ D G+Y C A N
Sbjct: 287 GDPVPTVRW--------RKDDGELPKSRYEIRDDHT----LKIRKVTAGDMGSYTCVAEN 334
Query: 641 VYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHK 700
+ E T+ QE P+ + D VA+ + T C A G P+P I W +
Sbjct: 335 MVGKAEA----SATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREG-- 388
Query: 701 IQQEPELYTSTSPSSSSSSPLSSS 724
+ L++ P SSS +S +
Sbjct: 389 --SQNLLFSYQPPQSSSRFSVSQT 410
Score = 48.9 bits (115), Expect = 2e-05
Identities = 79/318 (24%), Positives = 124/318 (38%), Gaps = 43/318 (13%)
Query: 108 KYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITV 167
KY+ V T+ E ES + FV+ S + + + + E R P TV
Sbjct: 237 KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLA--VTVDDSAEFKCEAR-GDPVPTV 293
Query: 168 TLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTN 227
+K D +P + I D I T ++G TC A N + + +
Sbjct: 294 RWRKD--DGELPKSRYEIRDDHT-LKIRKVTAGDMGSYTCVAE--------NMVGKAEAS 342
Query: 228 TIIDVQ-----ISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRI 282
+ VQ + PR + G T+ C AT N + + W +N S +
Sbjct: 343 ATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATG--NPQPAIFWRREGSQNLLFSYQP-- 398
Query: 283 DQSNSHANIFYSV-LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKH--- 338
QS+S ++ + LTI +Q D G Y C+ ++N + I KA++ V
Sbjct: 399 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQ--------TLNVAGSIITKAYLEVTDVIA 450
Query: 339 -------RKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG-LPATEKSARYLTRGYSL 390
R+ V +TVA ++ LS P P ++W KDG L +T+ S L
Sbjct: 451 DRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVL 510
Query: 391 IIKDVTEEDAGNYTILLS 408
I+ D G YT + S
Sbjct: 511 QIRYAKLGDTGRYTCIAS 528
Score = 42.7 bits (99), Expect = 0.001
Identities = 97/474 (20%), Positives = 162/474 (34%), Gaps = 74/474 (15%)
Query: 25 SGSKLKDPELSLKGTQH----IMQAGQTLHLQCRGEAAHKWSLPEMVSKESERLSITKSA 80
+GS+L+ + + +H I+ G+ L C+ E ++ K ER+ K
Sbjct: 57 TGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWY--KGGERVETDKDD 114
Query: 81 CGRN------GKQFCSTLTLNTAQANHTGFYSC---KYLAVPTSKKKETESAIYIFISDT 131
+ G F + G Y C YL S E AI
Sbjct: 115 PRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI------- 167
Query: 132 GRPFVEMYSEIPEIIHMTEGRELVIPCRVTS--PNITVTLKK--FPLDT-----LIPDGK 182
+ + + P + + G V+ C+ P T++ KK PLD I GK
Sbjct: 168 ---LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK 224
Query: 183 RIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKL 242
+I +RK + G C T N + R++ + P VK
Sbjct: 225 LMITYTRKS---------DAGKYVCVGT--------NMVGERESEVAELTVLERPSFVKR 267
Query: 243 LRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQ 302
+ ++ +A R + K+ + R + + H L I K+
Sbjct: 268 PSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHT------LKIRKVT 321
Query: 303 NKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAF 362
D G YTC + + ++ + + VK R Q VA R+ +
Sbjct: 322 AGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ----VVALGRTVTFQCEATGN 377
Query: 363 PSPEVVWLKDGL--------PATEKSARYLTRGYSLIIKDVTEEDAGNYTI-LLSIKQSN 413
P P + W ++G P S +++ L I +V D G Y L++ S
Sbjct: 378 PQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSI 437
Query: 414 VFKN-LTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKW 466
+ K L T ++ +P + P + +L+C A G P PTI W
Sbjct: 438 ITKAYLEVTDVIADRPP---PVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW 488
Score = 38.1 bits (87), Expect = 0.029
Identities = 22/78 (28%), Positives = 35/78 (44%), Gaps = 10/78 (12%)
Query: 642 YTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKI 701
YTG + Q + P ++ + SD V+ TL+C A G P P I W+K ++
Sbjct: 56 YTGSRLRQ-------EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERV 108
Query: 702 Q---QEPELYTSTSPSSS 716
+ +P + PS S
Sbjct: 109 ETDKDDPRSHRMLLPSGS 126
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 82.8 bits (203), Expect = 1e-15
Identities = 102/456 (22%), Positives = 170/456 (37%), Gaps = 69/456 (15%)
Query: 262 VQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKS 321
+ + W + D++ AS + + + H N + L I +++ D G YTC +
Sbjct: 4704 ISIQW-FKDDQEISASEKYKF---SFHDNTAF--LEISQLEGTDSGTYTCSATNKAGHNQ 4757
Query: 322 VNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSA 381
+ + + + + K + Q V +L V + W KD +A
Sbjct: 4758 CSGHLTVKEPPYFVEKPQSQDVNPNTR----VQLKALVGGTAPMTIKWFKDNKELHSGAA 4813
Query: 382 RYLTR---GYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSF 438
R + + SL + D+G Y LS ATL V PQ +K
Sbjct: 4814 RSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSK--ATLFVKEPPQFIKK----- 4866
Query: 439 PDPALYPL-GSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSN 497
P P L G C G P+ + W+ LD
Sbjct: 4867 PSPVLVLRNGQSTTFECQITGTPKIRVSWY------------------------LD---- 4898
Query: 498 MGNRIESITQR-MAIIEGKNKMASTLVVADSRI--SGIYICIASNKVGTVGRNISFYITD 554
GN I +I + ++ I+G +T ++ +R+ SG Y+C A N GT +I + +
Sbjct: 4899 -GNEITAIQKHGISFIDG----LATFQISGARVENSGTYVCEARNDAGTASCSIELKVKE 4953
Query: 555 VPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKE 614
P + D++L C V +VTW+ NNR + S +K +T
Sbjct: 4954 PPTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLK----NNREIR---SSKKYTLTDR 5006
Query: 615 HSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAI 674
S+ NL I D+G Y C N G + ++ E P ++ + + T +
Sbjct: 5007 VSV-FNLHITKCDPSDTGEYQCIVSN--EGGSCSCSTRVALK--EPPSFIKKIENTTTVL 5061
Query: 675 SSSTTLDCHANGVPEPQITWFKNNHKIQQEPELYTS 710
SS T G P ITW K++ + ++ +Y S
Sbjct: 5062 KSSATFQSTVAGSPPISITWLKDDQILDEDDNVYIS 5097
Score = 81.3 bits (199), Expect = 3e-15
Identities = 110/477 (23%), Positives = 172/477 (36%), Gaps = 67/477 (14%)
Query: 239 PVKLLRGHTLVLNC-TATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLT 297
P+ + G T L C A TP + + W Y D K +S + + N S L
Sbjct: 5712 PMTVTVGETCTLECKVAGTP---ELSVEW-YKDGKLLTSSQKHKFSFYNK-----ISSLR 5762
Query: 298 IDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSM 357
I ++ +D G YT +V++ S V + D+A R+ + V G S L
Sbjct: 5763 ILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGA-SCILEC 5821
Query: 358 KVKAFPSPEVVWLKDGLPATEKSARYLT----RGYSLIIKDVTEEDAGNYTILLSIKQSN 413
KV V W + A+Y T +L + + D GNYT + + +
Sbjct: 5822 KVAGSSPISVAWFHEKTKIVS-GAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGS 5880
Query: 414 VFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNH 473
A L V P ++ P+P G T G P + WF
Sbjct: 5881 --DECRAVLTVQEPPSFVKE-----PEPLEVLPGKNVTFTSVIRGTPPFKVNWF----RG 5929
Query: 474 NHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIY 533
+ D C+ E + + + L D SG Y
Sbjct: 5930 ARELVKGDRCNIYFEDTVAELE--------------------------LFNIDISQSGEY 5963
Query: 534 ICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTE-GEDLKLSCTVNKFLYRDVTWILL 592
C+ SN G ++ + P F L E G+ + L T L VTW
Sbjct: 5964 TCVVSNNAGQASCTTRLFVKE-PAAFLKRLSDHSVEPGKSIILESTYTGTLPISVTW--- 6019
Query: 593 RTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKE 652
+ + S++ +T E T L I+N + +D+G Y+C N G ++
Sbjct: 6020 ---KKDGFNITTSEKCNIVTTEK--TCILEILNSTKRDAGQYSCEIENE-AGRDVCGALV 6073
Query: 653 ITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPELYT 709
T+ E PY + L A+ S +L C G PE ++W+K + K++ PE T
Sbjct: 6074 STL---EPPYFVTELEPLEAAVGDSVSLQCQVAGTPEITVSWYKGDTKLRPTPEYRT 6127
Score = 78.2 bits (191), Expect = 3e-14
Identities = 115/527 (21%), Positives = 200/527 (37%), Gaps = 86/527 (16%)
Query: 192 FIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTP-------RPVKLLR 244
F+ SNA +G ++ +T N L + H + I++++ P+++
Sbjct: 3416 FVASNA----VGQVS--STANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVAL 3469
Query: 245 GHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNK 304
GH C + N R Q W K D+ + ++ + S L I + Q
Sbjct: 3470 GHLAKFTCEIQSAPNVRFQ--WF------KAGREIYESDKCSIRSSKYISSLEILRTQVV 3521
Query: 305 DKGLYTCRVRS---GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKA 361
D G YTC+ + S + T Y F++ + + L T GK + + V
Sbjct: 3522 DCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLS----RPKSLTTFVGKAA-KFICTVTG 3576
Query: 362 FPSPEVVWLKDGL---PATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKN- 417
P E +W KDG P+ + L + ++T +D G Y S K SN F
Sbjct: 3577 TPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVY----SCKASNKFGAD 3632
Query: 418 -LTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHS 476
A LI+ KP ++ +P + + L C + T+ W
Sbjct: 3633 ICQAELIIIDKPHFIKEL-----EPVQSAINKKVHLECQVDEDRKVTVTW---------- 3677
Query: 477 EARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICI 536
S G ++ E K + +A + SG Y+C
Sbjct: 3678 -------------------SKDGQKLPPGKDYKICFEDKIATLE-IPLAKLKDSGTYVCT 3717
Query: 537 ASNKVGTVGRNISFYITDVPNGFH-VNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTV 595
ASN+ G+ + + + + P+ V+ + GE +L C + VTW
Sbjct: 3718 ASNEAGSSSCSATVTVREPPSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFK---- 3773
Query: 596 NNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITI 655
NN+ + S + + + E L I +V ++DSG+Y+C A N + EI I
Sbjct: 3774 NNKELSESNTVRMYFVNSEAI----LDITDVKVEDSGSYSCEAVNDVGSDSC--STEIVI 3827
Query: 656 RDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQ 702
+ E P ++ L + ++ L C +G +I+WFK+ +I+
Sbjct: 3828 K--EPPSFIKTLEPADIVRGTNALLQCEVSGTGPFEISWFKDKKQIR 3872
Score = 77.8 bits (190), Expect = 3e-14
Identities = 109/437 (24%), Positives = 172/437 (39%), Gaps = 63/437 (14%)
Query: 268 YPDEKNKRASVRRRIDQSNSHANI-FYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSV 326
Y D + AS + RI N+ A + FYS + D G YT + + S T+
Sbjct: 4051 YKDGRPLVASKKYRISFKNNVAQLKFYSA------ELHDSGQYTFEISNEVGSSSCETTF 4104
Query: 327 HIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG--LPATEKSARYL 384
+ D+ + + +++V + RL K+ V W KDG + A+++
Sbjct: 4105 TVLDRDIAPFFTKPLRNVDSVVNG-TCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAF 4163
Query: 385 TRGY-SLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPAL 443
G SL I V DAGN+T + + K+ + LIV P K S P
Sbjct: 4164 VEGTASLEIIRVDMNDAGNFTCRATNSVGS--KDSSGALIVQEPPSFVTKPGSKDVLP-- 4219
Query: 444 YPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIE 503
GS L T G TI+WF N C +E+ +E
Sbjct: 4220 ---GSAVCLKSTFQGSTPLTIRWF----KGNKELVSGGSCYITKEA------------LE 4260
Query: 504 SITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNL 563
S + L + + SG Y C SN G V + + ++ + P F L
Sbjct: 4261 SSLE--------------LYLVKTSDSGTYTCKVSNVAGGVECSANLFVKE-PATFVEKL 4305
Query: 564 E--KMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNL 621
E ++ +G+ +L+C V +TW N+R + S SK +M+ + ++ L
Sbjct: 4306 EPSQLLKKGDATQLACKVTGTPPIKITWF----ANDREIKES-SKHRMSFVESTAV---L 4357
Query: 622 TIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLD 681
+ +V ++DSG Y C A+N G + I +E+PY + V L
Sbjct: 4358 RLTDVGIEDSGEYMCEAQNE-AGSDHCSSIVIV---KESPYFTKEFKPIEVLKEYDVMLL 4413
Query: 682 CHANGVPEPQITWFKNN 698
G P +ITWFK+N
Sbjct: 4414 AEVAGTPPFEITWFKDN 4430
Score = 77.4 bits (189), Expect = 4e-14
Identities = 98/432 (22%), Positives = 157/432 (36%), Gaps = 75/432 (17%)
Query: 294 SVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSY 353
S+L I + KD G YT V++ S +++ D +K + ++++ G
Sbjct: 4634 SILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIPPSFTKKLKKMDSIKGS-FI 4692
Query: 354 RLSMKVKAFPSPEVVWLKDG--LPATEK-SARYLTRGYSLIIKDVTEEDAGNYTILLSIK 410
L V + W KD + A+EK + L I + D+G YT + K
Sbjct: 4693 DLECIVAGSHPISIQWFKDDQEISASEKYKFSFHDNTAFLEISQLEGTDSGTYTCSATNK 4752
Query: 411 QSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHP 470
+ + L V P EK S +P +R L G TIKWF
Sbjct: 4753 AGH--NQCSGHLTVKEPPYFVEKPQSQDVNP-----NTRVQLKALVGGTAPMTIKWF--- 4802
Query: 471 CNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS 530
+N+E + S R ++ + + L A + S
Sbjct: 4803 -------------KDNKE-------------LHSGAAR-SVWKDDTSTSLELFAAKATDS 4835
Query: 531 GIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPT------EGEDLKLSCTVNKFLY 584
G YIC SN VGT + ++ + P K P+ G+ C +
Sbjct: 4836 GTYICQLSNDVGTATSKATLFVKEPPQFI-----KKPSPVLVLRNGQSTTFECQITGTPK 4890
Query: 585 RDVTWILLRTVNNRTMHYSISKQKMAITKEHSITL-----NLTIMNVSLQDSGTYACRAR 639
V+W L ++ ++H I+ I +++SGTY C AR
Sbjct: 4891 IRVSWYL-------------DGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCEAR 4937
Query: 640 NVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNH 699
N + I ++ +E P +R L V S L+C G P ++TW KNN
Sbjct: 4938 N----DAGTASCSIELKVKEPPTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLKNNR 4993
Query: 700 KIQQEPELYTST 711
+I+ + YT T
Sbjct: 4994 EIRSSKK-YTLT 5004
Score = 73.6 bits (179), Expect = 6e-13
Identities = 148/665 (22%), Positives = 247/665 (37%), Gaps = 116/665 (17%)
Query: 90 STLTLNTAQANHTGFYSCKYLA-VPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHM 148
++L L A+A +G Y C+ V T+ K T +F+ + + F++ S + + +
Sbjct: 4823 TSLELFAAKATDSGTYICQLSNDVGTATSKAT-----LFVKEPPQ-FIKKPSPV---LVL 4873
Query: 149 TEGRELVIPCRVT-SPNITVT--LKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLL 205
G+ C++T +P I V+ L + + G I D F IS A + G
Sbjct: 4874 RNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFI-DGLATFQISGARVENSGTY 4932
Query: 206 TCEATVNGHLYKTNYLTHRQTNTIIDVQISTP-------RPVKLLRGHTLVLNC--TATT 256
CEA + + I++++ P +PV++++ + L C T T
Sbjct: 4933 VCEARNDAGTASCS----------IELKVKEPPTFIRELKPVEVVKYSDVELECEVTGTP 4982
Query: 257 PLNTRVQMTWSYPDEK---NKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRV 313
P ++TW + + +K+ ++ R+ N H I K D G Y C V
Sbjct: 4983 PF----EVTWLKNNREIRSSKKYTLTDRVSVFNLH---------ITKCDPSDTGEYQCIV 5029
Query: 314 RSGPSFKSVNTSVHIYDK-AFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKD 372
+ S +T V + + +FI VL++ A +S V P + WLKD
Sbjct: 5030 SNEGGSCSCSTRVALKEPPSFIKKIENTTTVLKSSATFQS-----TVAGSPPISITWLKD 5084
Query: 373 GLPATEKSARYLTRGYS---LIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQ 429
E Y++ S L I+ V +G YT K + + A L+V Q
Sbjct: 5085 DQILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTC--QAKNESGVERCYAFLLVQEPAQ 5142
Query: 430 IYEKAVS---SFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNN 486
I EKA S + DP L C G P+ +KW S NN
Sbjct: 5143 IVEKAKSVDVTEKDP--------MTLECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENN 5194
Query: 487 EESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGR 546
SF RI+S+ ++ SG Y N G+
Sbjct: 5195 VASF----------RIQSVMKQD--------------------SGQYTFKVENDFGSSSC 5224
Query: 547 NISFYITD--VPNGFHVNLEKMPTE-GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYS 603
+ + D +P F L KM G + + C V+ L W S
Sbjct: 5225 DAYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWF------KDGKEIS 5278
Query: 604 ISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYL 663
S + + E S++L + N+ L+D+ Y C+ NV G++ + +E P
Sbjct: 5279 TSAKYRLVCHERSVSLEVN--NLELEDTANYTCKVSNV-AGDDACSG---ILTVKEPPSF 5332
Query: 664 LRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPELYTSTSPSSSSSSPLSS 723
L S+ G P +I WFK++ ++ P+ + S+S + S
Sbjct: 5333 LVKPGRQQAIPDSTVEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSV 5392
Query: 724 SSSSS 728
+S +
Sbjct: 5393 DASKT 5397
Score = 72.0 bits (175), Expect = 2e-12
Identities = 155/721 (21%), Positives = 275/721 (38%), Gaps = 103/721 (14%)
Query: 29 LKDPELSLKG-TQHIMQAGQTLHLQCRGEAAHKWSLPEMVSKESERLSITKSA-CGRNGK 86
+K+P LK + H ++ G+++ L E+ + +LP V+ + + +IT S C
Sbjct: 5982 VKEPAAFLKRLSDHSVEPGKSIIL----ESTYTGTLPISVTWKKDGFNITTSEKCNIVTT 6037
Query: 87 QFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEII 146
+ L + + G YSC+ + ++ A+ +S P+ +E+ E +
Sbjct: 6038 EKTCILEILNSTKRDAGQYSCE---IENEAGRDVCGAL---VSTLEPPY--FVTEL-EPL 6088
Query: 147 HMTEGRELVIPCRVT-SPNITVTLKKFPLDTLI---PDGKRIIWDSRKGFIISNATYKEI 202
G + + C+V +P ITV+ K DT + P+ + ++ + + +
Sbjct: 6089 EAAVGDSVSLQCQVAGTPEITVSWYKG--DTKLRPTPEYRTYFTNNVATLVFNKVNINDS 6146
Query: 203 GLLTCEATVNGHLYKTNYLTHRQTNTIIDVQI-----STPRPVKLLRGHTLVLNCTATTP 257
G TC+A N + + T+ +Q S R +K + T+ L T T
Sbjct: 6147 GEYTCKAE--------NSIGTASSKTVFRIQERQLPPSFARQLKDIE-QTVGLPVTLTCR 6197
Query: 258 LN--TRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQN--KDKGLYTCRV 313
LN +Q+ W Y D R D N + +V T+ +Q G Y+C
Sbjct: 6198 LNGSAPIQVCW-YRDGVLLR-------DDENLQTSFVDNVATLKILQTDLSHSGQYSCSA 6249
Query: 314 RSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG 373
+ S + + + K ++ +AG+ S V + W KD
Sbjct: 6250 SNPLGTASSSARLTAREPKKSPFFDIKPVSIDVIAGE-SADFECHVTGAQPMRITWSKDN 6308
Query: 374 L---PATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNL-TATLIVNVKPQ 429
P + + L I V + D+G YT + ++V K++ +A L V P+
Sbjct: 6309 KEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQAT---NDVGKDMCSAQLSVKEPPK 6365
Query: 430 IYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEES 489
+K +S + G L C G P+ + WF N SE
Sbjct: 6366 FVKKLEAS----KVAKQGESIQLECKISGSPEIKVSWF-----RNDSELH---------- 6406
Query: 490 FILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNIS 549
ES M+ I + T+ A + SG YIC A N VG + +
Sbjct: 6407 -------------ESWKYNMSFINSVALL--TINEASAEDSGDYICEAHNGVGDASCSTA 6451
Query: 550 FYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRT-VNNRTMHYSISKQK 608
+ P +G D+ L C ++ +V W+ R V N +K
Sbjct: 6452 LTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRN--------SKK 6503
Query: 609 MAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLS 668
IT +H T +L I+N+ D G Y C+A N + +++ +E P ++ LS
Sbjct: 6504 FKITSKHFDT-SLHILNLEASDVGEYHCKATNEVGSDTC----SCSVKFKEPPRFVKKLS 6558
Query: 669 DHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPELYTSTSPSSSSSSPLSSSSSSS 728
D + I + L G + W K+ ++ +E E + + ++ L S +S+
Sbjct: 6559 DTSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFIDNIATLQLGSPEASN 6618
Query: 729 S 729
S
Sbjct: 6619 S 6619
Score = 67.4 bits (163), Expect = 5e-11
Identities = 120/605 (19%), Positives = 216/605 (35%), Gaps = 75/605 (12%)
Query: 138 MYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNA 197
++S P I+ + E+ + C ++ P + + KR + S+K I S
Sbjct: 5518 VFSSFPPIVETLKNAEVSLECELSGTP--------PFEVVWYKDKRQLRSSKKYKIASKN 5569
Query: 198 TYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTP-RPVKLLRGHTLVLNCTATT 256
+ I +L + + G + + V++ P R V L T+V A
Sbjct: 5570 FHTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLKEPPRFVSKLNSLTVVAGEPAEL 5629
Query: 257 PLNTR----VQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCR 312
+ + + W E+ R S RI + A + ++ K + + G Y C+
Sbjct: 5630 QASIEGAQPIFVQWLKEKEEVIRESENIRITFVENVATLQFA-----KAEPANAGKYICQ 5684
Query: 313 VRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKD 372
+++ + ++ + + A I K TV + L KV P V W KD
Sbjct: 5685 IKNDGGMRENMATLMVLEPAVIVEKAGPM----TVTVGETCTLECKVAGTPELSVEWYKD 5740
Query: 373 GLPATEKSAR---YLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQ 429
G T + + SL I V +DAG YT + Q+NV K+ + T +V+V +
Sbjct: 5741 GKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQV---QNNVGKS-SCTAVVDVSDR 5796
Query: 430 IYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEES 489
+ + LG+ IL C G ++ WF H + + + + +
Sbjct: 5797 AVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWF-------HEKTKIVSGAKYQTT 5849
Query: 490 FILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNIS 549
F N L DS G Y C+A+N G+
Sbjct: 5850 F-----------------------SDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAV 5886
Query: 550 FYITDVPNGFHVN--LEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQ 607
+ + P+ LE +P G+++ + + V W R +
Sbjct: 5887 LTVQEPPSFVKEPEPLEVLP--GKNVTFTSVIRGTPPFKVNWF-------RGARELVKGD 5937
Query: 608 KMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNL 667
+ I E ++ L + N+ + SG Y C N + + +++ A L+ L
Sbjct: 5938 RCNIYFEDTVA-ELELFNIDISQSGEYTCVVSN--NAGQASCTTRLFVKEPAA--FLKRL 5992
Query: 668 SDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPELYTSTSPSSSSSSPLSSSSSS 727
SDH+V S L+ G +TW K+ I + T+ + L+S+
Sbjct: 5993 SDHSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRD 6052
Query: 728 SSSSS 732
+ S
Sbjct: 6053 AGQYS 6057
Score = 62.0 bits (149), Expect = 2e-09
Identities = 130/683 (19%), Positives = 234/683 (34%), Gaps = 96/683 (14%)
Query: 39 TQHIMQAGQTLHLQCRGEAAHKWSLPEMVSKESERLSITKSACGRN--GKQFCSTLTLNT 96
T+ + G L C E S P V+ E+ I A + C TL LN+
Sbjct: 5803 TRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVC-TLQLNS 5861
Query: 97 AQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVI 156
++ G Y+C +A + E + + + E P + E E++
Sbjct: 5862 LDSSDMGNYTC--VAANVAGSDECRAVLTV-------------QEPPSFVKEPEPLEVLP 5906
Query: 157 PCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLY 216
VT ++ F ++ G R + + I T E+ L + + +G
Sbjct: 5907 GKNVTFTSVIRGTPPFKVNWF--RGARELVKGDRCNIYFEDTVAELELFNIDISQSGEY- 5963
Query: 217 KTNYLTHRQTNTIIDVQISTPRPVKLLR---------GHTLVLNCTATTPLNTRVQMTWS 267
T +++ ++ P L+ G +++L T T L + +TW
Sbjct: 5964 -TCVVSNNAGQASCTTRLFVKEPAAFLKRLSDHSVEPGKSIILESTYTGTLP--ISVTWK 6020
Query: 268 YPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVH 327
D N S + I + +L I +D G Y+C + + V
Sbjct: 6021 -KDGFNITTSEKCNIVTTEKTC-----ILEILNSTKRDAGQYSCEIENEAGRDVCGALVS 6074
Query: 328 IYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGL---PATEKSARYL 384
+ + + + LE G S L +V P V W K P E +
Sbjct: 6075 TLEPPYFVTE---LEPLEAAVGD-SVSLQCQVAGTPEITVSWYKGDTKLRPTPEYRTYFT 6130
Query: 385 TRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALY 444
+L+ V D+G YT K N ++ + ++ + + +
Sbjct: 6131 NNVATLVFNKVNINDSGEYTC----KAENSIGTASSKTVFRIQERQLPPSFARQLKDIEQ 6186
Query: 445 PLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIES 504
+G LTC G + W+ + +L D N+
Sbjct: 6187 TVGLPVTLTCRLNGSAPIQVCWY-------------------RDGVLLRDDENLQTSFVD 6227
Query: 505 ITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLE 564
+ I++ D SG Y C ASN +GT + + +++
Sbjct: 6228 NVATLKILQ-----------TDLSHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIK 6276
Query: 565 KMPTE---GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNL 621
+ + GE C V +TW +Y+I+ T +L
Sbjct: 6277 PVSIDVIAGESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCV--------GNTPHL 6328
Query: 622 TIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISS-STTL 680
I+ V DSG Y C+A N G+++ + + +E P ++ L VA S L
Sbjct: 6329 RILKVGKGDSGQYTCQATND-VGKDMCSAQ---LSVKEPPKFVKKLEASKVAKQGESIQL 6384
Query: 681 DCHANGVPEPQITWFKNNHKIQQ 703
+C +G PE +++WF+N+ ++ +
Sbjct: 6385 ECKISGSPEIKVSWFRNDSELHE 6407
Score = 62.0 bits (149), Expect = 2e-09
Identities = 132/692 (19%), Positives = 251/692 (36%), Gaps = 118/692 (17%)
Query: 46 GQTLHLQCRGEAAHKWSLP------EMVSKESERLSITKSACGRNGKQFCSTLTLNTAQA 99
G ++ L+CR + S+ E+VS + S +++ C TL L+ +
Sbjct: 6755 GASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVC---------TLNLSLLEP 6805
Query: 100 NHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCR 159
+ TG Y+C V + E + + + + + + P+ + + G L
Sbjct: 6806 SDTGIYTC----VAANVAGSDECSAVLTVQEP-----PSFEQTPDSVEVLPGMSLTFTSV 6856
Query: 160 VT-SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYK----EIGLLTCEATVN-G 213
+ +P V K + + + I S + F+ ++ E G +C T + G
Sbjct: 6857 IRGTPPFKVKWFKGSRELVPGESCNI---SLEDFVTELELFEVQPLESGDYSCLVTNDAG 6913
Query: 214 HLYKTNYLTHRQTNTII----DVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYP 269
T +L ++ T + D + T P+ L T T P++ ++W
Sbjct: 6914 SASCTTHLFVKEPATFVKRLADFSVETGSPI------VLEATYTGTPPIS----VSW-IK 6962
Query: 270 DEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIY 329
DE S R I + ++L I + +D Y+C + + V +
Sbjct: 6963 DEYLISQSERCSITMTEKS-----TILEILESTIEDYAQYSCLIENEAGQDICEALVSVL 7017
Query: 330 DKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSA---RYLTR 386
+ + + +E V G+ + L KV P + W K+ A ++
Sbjct: 7018 EPPYFI---EPLEHVEAVIGEPA-TLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNN 7073
Query: 387 GYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVK----PQIYEKAVSSFPDPA 442
SL+I V D G Y S K N + ++ ++ +K P + + + +
Sbjct: 7074 VASLVINKVDHSDVGEY----SCKADNSVGAVASSAVLVIKARKLPPFFARKLKDVHETL 7129
Query: 443 LYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRI 502
+P+ C G + W+ ++ +L D+N+
Sbjct: 7130 GFPVA----FECRINGSEPLQVSWY-------------------KDGVLLKDDANLQT-- 7164
Query: 503 ESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITD--VPNGFH 560
S +A ++ ++ D G Y C ASN +GT + +++ VP F
Sbjct: 7165 -SFVHNVATLQ--------ILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFFD 7215
Query: 561 VNLEKMPTE-GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITL 619
+ + GE C V +TW +NR + KM + + T
Sbjct: 7216 LKPVSVDLALGESGTFKCHVTGTAPIKITW----AKDNREIRPG-GNYKMTLVEN---TA 7267
Query: 620 NLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSS-T 678
LT++ V D+G Y C A N+ + + + QE P ++ L + T
Sbjct: 7268 TLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGV----QEPPRFIKKLEPSRIVKQDEFT 7323
Query: 679 TLDCHANGVPEPQITWFKNNHKIQQEPELYTS 710
+C G PE ++ W+K+ +IQ+ + S
Sbjct: 7324 RYECKIGGSPEIKVLWYKDETEIQESSKFRMS 7355
Score = 61.6 bits (148), Expect = 2e-09
Identities = 125/588 (21%), Positives = 212/588 (36%), Gaps = 89/588 (15%)
Query: 141 EIPEIIHMTEGRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRIIWDSR---------K 190
E PE I +T G + C V +P ++ K DGK + D++
Sbjct: 7590 EKPESIKVTTGDTCTLECTVAGTPELSTKWFK--------DGKELTSDNKYKISFFNKVS 7641
Query: 191 GFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKL---LRGHT 247
G I N + G+ + E V + K + Q + V S R +K L G +
Sbjct: 7642 GLKIINVAPSDSGVYSFE--VQNPVGKDSCTASLQVSDRT-VPPSFTRKLKETNGLSGSS 7698
Query: 248 LVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKG 307
+V+ C + + ++W + E N+ +S R+ + LT++ ++ D G
Sbjct: 7699 VVMECKVYG--SPPISVSWFH--EGNEISSGRKYQTTLTDNT----CALTVNMLEESDSG 7750
Query: 308 LYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEV 367
YTC + + + + + K VL + + VK P V
Sbjct: 7751 DYTCIATNMAGSDECSAPLTVREPPSFVQKPDPMDVLTGT----NVTFTSIVKGTPPFSV 7806
Query: 368 VWLKDG---LPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIV 424
W K +P + L + DV +G YT ++S + + T L +
Sbjct: 7807 SWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKA--SCTTHLYI 7864
Query: 425 NVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCS 484
P + K ++ + PL IL T G P ++ W + N S+ RC+ +
Sbjct: 7865 KA-PAKFVKRLNDYSIEKGKPL----ILEGTFTGTPPISVTWKKNGINVTPSQ-RCNI-T 7917
Query: 485 NNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTV 544
E+S IL+ S+ V D+ G Y C N G
Sbjct: 7918 TTEKSAILEIPSS-------------------------TVEDA---GQYNCYIENASGKD 7949
Query: 545 GRNISFYITDVPNGFHVNLEKMPTE-GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYS 603
+ I + P F LE + G+ L C + V+W T T Y
Sbjct: 7950 SCSAQILILEPPY-FVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYK 8008
Query: 604 ISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAP-Y 662
+ + T L V + DSG Y C+A N + E+ +T+++Q+ P
Sbjct: 8009 MHFRNNVAT--------LVFNQVDINDSGEYICKAEN--SVGEVSASTFLTVQEQKLPPS 8058
Query: 663 LLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPELYTS 710
R L D + DC +G ++W+K+ ++ P + TS
Sbjct: 8059 FSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTS 8106
Score = 60.8 bits (146), Expect = 4e-09
Identities = 110/519 (21%), Positives = 187/519 (36%), Gaps = 72/519 (13%)
Query: 201 EIGLLTCEATVN-GHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTAT-TPL 258
+ G TC+A+ G + T LT T +S P+ + G CT T TP+
Sbjct: 3522 DCGEYTCKASNEYGSVSCTATLT--VTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPV 3579
Query: 259 NTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPS 318
++ W + R D N H +L + + +D+G+Y+C+ +
Sbjct: 3580 ---IETIWQKDGAALSPSPNWRISDAENKH------ILELSNLTIQDRGVYSCKASNKFG 3630
Query: 319 FKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGL---P 375
+ I DK ++ + +++ K+ + L +V V W KDG P
Sbjct: 3631 ADICQAELIIIDKPHFI---KELEPVQSAINKKVH-LECQVDEDRKVTVTWSKDGQKLPP 3686
Query: 376 ATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV 435
+ + + +L I +D+G Y S + + + +AT+ V P +K
Sbjct: 3687 GKDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAGS--SSCSATVTVREPPSFVKKV- 3743
Query: 436 SSFPDPALYPL-GSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDA 494
DP+ L G L C G P + WF NN+E
Sbjct: 3744 ----DPSYLMLPGESARLHCKLKGSPVIQVTWF----------------KNNKELS---- 3779
Query: 495 DSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITD 554
ES T RM + + + T V + SG Y C A N VG+ + I +
Sbjct: 3780 --------ESNTVRMYFVNSEAILDITDVKVED--SGSYSCEAVNDVGSDSCSTEIVIKE 3829
Query: 555 VPNGFHVNLEKMP-TEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITK 613
P+ F LE G + L C V+ +++W + + Y + QK +
Sbjct: 3830 PPS-FIKTLEPADIVRGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVCL 3888
Query: 614 EHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVA 673
E I + + D G Y C N + + +E P ++ + D
Sbjct: 3889 E--------IFSFNSADVGEYECVVANEVGKCGCMATHLL----KEPPTFVKKVDDLIAL 3936
Query: 674 ISSSTTLDCHANGVPEPQITWFKNNHKIQQEPELYTSTS 712
+ TL G +TW K I+++ ++ S S
Sbjct: 3937 GGQTVTLQAAVRGSEPISVTWMKGQEVIREDGKIKMSFS 3975
Score = 60.8 bits (146), Expect = 4e-09
Identities = 123/636 (19%), Positives = 235/636 (36%), Gaps = 102/636 (16%)
Query: 90 STLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPE---II 146
+TL + + H+G Y+C+ +K + Y F+ V+ ++I E +
Sbjct: 5103 ATLQIRSVDNGHSGRYTCQ------AKNESGVERCYAFL------LVQEPAQIVEKAKSV 5150
Query: 147 HMTEGRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRII---------WDSRKGFIISN 196
+TE + + C V +P + V K DGK+I+ ++ F I +
Sbjct: 5151 DVTEKDPMTLECVVAGTPELKVKWLK--------DGKQIVPSRYFSMSFENNVASFRIQS 5202
Query: 197 ATYKEIGLLTCEATVN-GHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTAT 255
++ G T + + G YL N + K+L G ++ + C +
Sbjct: 5203 VMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVL-GSSIHMECKVS 5261
Query: 256 TPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS 315
L Q W + D K S + R+ + L ++ ++ +D YTC+V +
Sbjct: 5262 GSLPISAQ--W-FKDGKEISTSAKYRLVCHERSVS-----LEVNNLELEDTANYTCKVSN 5313
Query: 316 GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLP 375
+ + + + + VK +QQ + + +K P ++ W KD +
Sbjct: 5314 VAGDDACSGILTVKEPPSFLVKPGRQQAIP----DSTVEFKAILKGTPPFKIKWFKDDVE 5369
Query: 376 ATEKSARYLTRGYSLIIKDVTEEDA---GNYTILLSIKQSNVFKNLTATLIVNVKPQIYE 432
++ S ++ DA G YT ++ + + T L+V P+ +
Sbjct: 5370 LVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGS--DSCTTMLLVTEPPKFVK 5427
Query: 433 KAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFIL 492
K +S + G L C G P+ + WF E +
Sbjct: 5428 KLEAS----KIVKAGDSSRLECKIAGSPEIRVVWF------------------RNEHELP 5465
Query: 493 DADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYI 552
+D I+S+ A+I+ N + SG +IC A N G+ + +
Sbjct: 5466 ASDKYRMTFIDSV----AVIQMNN--------LSTEDSGDFICEAQNPAGSTSCSTKVIV 5513
Query: 553 TDVP--NGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMA 610
+ P + F +E + + ++ L C ++ +V W ++ S K K+A
Sbjct: 5514 KEPPVFSSFPPIVETL--KNAEVSLECELSGTPPFEVVW-----YKDKRQLRSSKKYKIA 5566
Query: 611 ITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDH 670
H+ ++ I+NV D G Y C+A+N + + T++ +E P + L+
Sbjct: 5567 SKNFHT---SIHILNVDTSDIGEYHCKAQNEVGSDTCV----CTVKLKEPPRFVSKLNSL 5619
Query: 671 TVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPE 706
TV L G + W K ++ +E E
Sbjct: 5620 TVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESE 5655
Score = 60.5 bits (145), Expect = 6e-09
Identities = 126/591 (21%), Positives = 221/591 (37%), Gaps = 79/591 (13%)
Query: 151 GRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRI---IWDSRKGFIISNATYKEIGLLT 206
G +V+ C+V SP I+V+ F I G++ + D+ ++ + G T
Sbjct: 7696 GSSVVMECKVYGSPPISVSW--FHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYT 7753
Query: 207 CEAT-VNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMT 265
C AT + G + LT R+ + + P P+ +L G + T+ ++
Sbjct: 7754 CIATNMAGSDECSAPLTVREPPSFVQ----KPDPMDVLTGTNVTF--TSIVKGTPPFSVS 7807
Query: 266 WSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTS 325
W K +S D+ N + L + + G YTC V + S T
Sbjct: 7808 WF------KGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTT- 7860
Query: 326 VHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLT 385
H+Y KA K K+ ++ + L P V W K+G+ T +T
Sbjct: 7861 -HLYIKA--PAKFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNIT 7917
Query: 386 ---RGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPA 442
+ L I T EDAG Y + K+ + I+ ++P + K + +P
Sbjct: 7918 TTEKSAILEIPSSTVEDAGQYNCYIENASG---KDSCSAQILILEPPYFVKQL----EPV 7970
Query: 443 LYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRI 502
+G L C G P+ + W+ D+ +
Sbjct: 7971 KVSVGDSASLQCQLAGTPEIGVSWY-------------------------KGDTKLR--- 8002
Query: 503 ESITQRMAIIEGKNKMASTLVV--ADSRISGIYICIASNKVGTVGRNISFYITD--VPNG 558
+ T +M +N +A TLV D SG YIC A N VG V + + + +P
Sbjct: 8003 PTTTYKMHF---RNNVA-TLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPS 8058
Query: 559 FHVNLEKMP-TEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSI 617
F L + T G + C ++ V+W + + + S + Q + +++
Sbjct: 8059 FSRQLRDVQETVGLPVVFDCAISGSEPISVSWYK----DGKPLKDSPNVQTSFL--DNTA 8112
Query: 618 TLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSS 677
TLN+ + SL +G Y+C A N G + I + P+ L+ + S
Sbjct: 8113 TLNIFKTDRSL--AGQYSCTATNPI-GSASSSARLILTEGKNPPFFDIRLAPVDAVVGES 8169
Query: 678 TTLDCHANGVPEPQITWFKNNHKIQQEPELYTSTSPSSSSSSPLSSSSSSS 728
+CH G +++W K++ +I+ + S +S+ + L S
Sbjct: 8170 ADFECHVTGTQPIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDS 8220
Score = 59.7 bits (143), Expect = 9e-09
Identities = 90/417 (21%), Positives = 155/417 (37%), Gaps = 60/417 (14%)
Query: 294 SVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSY 353
+VL I +Q G YTC + ++ + + + A I + ++++ AG +
Sbjct: 3979 AVLIIPDVQISFGGKYTCLAENEAGSQTSVGELIVKEPAKII---ERAELIQVTAGDPA- 4034
Query: 354 RLSMKVKAFPSPEVVWLKDGLP-ATEKSARYLTRGYSLIIKDVTEE--DAGNYTILLSIK 410
L V P + W KDG P K R + +K + E D+G YT +S +
Sbjct: 4035 TLEYTVAGTPELKPKWYKDGRPLVASKKYRISFKNNVAQLKFYSAELHDSGQYTFEISNE 4094
Query: 411 QSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHP 470
+ T T++ + K + + + L C G + WF
Sbjct: 4095 VGSSSCETTFTVLDRDIAPFFTKPLRNVDSV----VNGTCRLDCKIAGSLPMRVSWF--- 4147
Query: 471 CNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS 530
+ +E D R+A +EG + ++ D +
Sbjct: 4148 -------------KDGKEIAASDR------------YRIAFVEGTASLE--IIRVDMNDA 4180
Query: 531 GIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWI 590
G + C A+N VG+ + + + + P+ K G + L T + W
Sbjct: 4181 GNFTCRATNSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWF 4240
Query: 591 LLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEE---- 646
N+ + +S ITKE ++ +L + V DSGTY C+ NV G E
Sbjct: 4241 K----GNKEL---VSGGSCYITKE-ALESSLELYLVKTSDSGTYTCKVSNVAGGVECSAN 4292
Query: 647 ILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQ 703
+ K+ T ++ P L D +T L C G P +ITWF N+ +I++
Sbjct: 4293 LFVKEPATFVEKLEPSQLLKKGD-------ATQLACKVTGTPPIKITWFANDREIKE 4342
Score = 58.5 bits (140), Expect = 2e-08
Identities = 137/627 (21%), Positives = 239/627 (38%), Gaps = 93/627 (14%)
Query: 90 STLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMT 149
S L L + A+ TG Y+C + ++S + + FV+ E +I+
Sbjct: 5385 SFLNLYSVDASKTGQYTCH-----VTNDVGSDSCTTMLLVTEPPKFVKKL-EASKIVKAG 5438
Query: 150 EGRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRIIW-DSRKGFIISNATYKEIGLLTC 207
+ L C++ SP I V + + D R+ + DS ++N + ++ G C
Sbjct: 5439 DSSRL--ECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFIC 5496
Query: 208 EATVNGHLYKTNYLTHRQTNTIID---VQISTPRPVKLLRGHTLVLNC--TATTPLNTRV 262
EA T T I+ V S P V+ L+ + L C + T P
Sbjct: 5497 EAQ------NPAGSTSCSTKVIVKEPPVFSSFPPIVETLKNAEVSLECELSGTPPF---- 5546
Query: 263 QMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSV 322
++ W Y D++ R+S + +I N H +I +L +D D G Y C+ ++ +
Sbjct: 5547 EVVW-YKDKRQLRSSKKYKIASKNFHTSI--HILNVD---TSDIGEYHCKAQNEVGSDTC 5600
Query: 323 NTSVHIYD-KAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSA 381
+V + + F++ K L VAG+ + L ++ V WLK+ +S
Sbjct: 5601 VCTVKLKEPPRFVS----KLNSLTVVAGEPA-ELQASIEGAQPIFVQWLKEKEEVIRESE 5655
Query: 382 R----YLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSS 437
++ +L +AG Y + IK + ATL+V I EKA
Sbjct: 5656 NIRITFVENVATLQFAKAEPANAGKY--ICQIKNDGGMRENMATLMVLEPAVIVEKA--- 5710
Query: 438 FPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSN 497
P +G L C G P+ +++W+ + + S+ + F +
Sbjct: 5711 --GPMTVTVGETCTLECKVAGTPELSVEWY--------KDGKL-LTSSQKHKF------S 5753
Query: 498 MGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITD--V 555
N+I S+ R+ +E ++ +G Y N VG ++D V
Sbjct: 5754 FYNKISSL--RILSVERQD-------------AGTYTFQVQNNVGKSSCTAVVDVSDRAV 5798
Query: 556 PNGFHVNLEKM-PTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKE 614
P F L+ G L C V V W + +T S +K + + +
Sbjct: 5799 PPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWF-----HEKTKIVSGAKYQTTFS-D 5852
Query: 615 HSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAI 674
+ TL L ++ S D G Y C A NV +E + +T+ QE P ++ V
Sbjct: 5853 NVCTLQLNSLDSS--DMGNYTCVAANVAGSDEC--RAVLTV--QEPPSFVKEPEPLEVLP 5906
Query: 675 SSSTTLDCHANGVPEPQITWFKNNHKI 701
+ T G P ++ WF+ ++
Sbjct: 5907 GKNVTFTSVIRGTPPFKVNWFRGAREL 5933
Score = 57.0 bits (136), Expect = 6e-08
Identities = 117/528 (22%), Positives = 189/528 (35%), Gaps = 96/528 (18%)
Query: 192 FIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLN 251
F ISN E+G +CE T T++D I+ P K LR V+N
Sbjct: 4089 FEISN----EVGSSSCETTF----------------TVLDRDIA-PFFTKPLRNVDSVVN 4127
Query: 252 CTATTPLNTR----VQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKG 307
T ++++W + D K AS R RI A+ L I ++ D G
Sbjct: 4128 GTCRLDCKIAGSLPMRVSW-FKDGKEIAASDRYRIAFVEGTAS-----LEIIRVDMNDAG 4181
Query: 308 LYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVL--ETVAGKRSYRLSMKVKAFPSP 365
+TCR + K + ++ + + K + VL V K +++ S +
Sbjct: 4182 NFTCRATNSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLT----- 4236
Query: 366 EVVWLKDGLPATEKSARYLTRGY---SLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATL 422
+ W K + Y+T+ SL + V D+G YT +S V +A L
Sbjct: 4237 -IRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGV--ECSANL 4293
Query: 423 IVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDF 482
V EK S L G L C G P I WF
Sbjct: 4294 FVKEPATFVEKLEPS----QLLKKGDATQLACKVTGTPPIKITWF--------------- 4334
Query: 483 CSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVG 542
+N+ E ES RM+ +E + T V + SG Y+C A N+ G
Sbjct: 4335 -ANDREIK------------ESSKHRMSFVESTAVLRLTDVGIED--SGEYMCEAQNEAG 4379
Query: 543 TVGRNISFYITDVPNGFHVNLEKMPTE---GEDLKLSCTVNKFLYRDVTWILLRTVNNRT 599
+ + + + P + E P E D+ L V ++TW T+
Sbjct: 4380 SDHCSSIVIVKESP---YFTKEFKPIEVLKEYDVMLLAEVAGTPPFEITWFKDNTILRSG 4436
Query: 600 MHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQE 659
Y ++H ++L I+ D+G Y CR N G I + +T+R E
Sbjct: 4437 RKYK------TFIQDHLVSLQ--ILKFVAADAGEYQCRVTN-EVGSSICSAR-VTLR--E 4484
Query: 660 APYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPEL 707
P ++ + + + G +TW K++ +I ++ +
Sbjct: 4485 PPSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNI 4532
Score = 56.6 bits (135), Expect = 8e-08
Identities = 163/756 (21%), Positives = 274/756 (36%), Gaps = 155/756 (20%)
Query: 28 KLKDPELSLKGTQHI-MQAGQTLHLQCRGEAAH----KW-SLPEMVSKESERLSITKSAC 81
KLK+P + + + AG+ LQ E A +W E V +ESE + IT
Sbjct: 5605 KLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFV-- 5662
Query: 82 GRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSE 141
+ +TL A+ + G Y C+ +E + + + P V +
Sbjct: 5663 -----ENVATLQFAKAEPANAGKYICQIKN--DGGMRENMATLMVL-----EPAVIVEKA 5710
Query: 142 IPEIIHMTEGRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYK 200
P + T G + C+V +P ++V K DGK + + F N
Sbjct: 5711 GPMTV--TVGETCTLECKVAGTPELSVEWYK--------DGKLLTSSQKHKFSFYNKI-S 5759
Query: 201 EIGLLTCEATVNGH--LYKTNYLTHRQTNTIIDVQISTPRPVKLLR--------GHTLVL 250
+ +L+ E G N + ++DV P R G + +L
Sbjct: 5760 SLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCIL 5819
Query: 251 NCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYT 310
C ++ + + W + EK K S + Q+ N+ L ++ + + D G YT
Sbjct: 5820 ECKVAG--SSPISVAWFH--EKTKIVSGAKY--QTTFSDNV--CTLQLNSLDSSDMGNYT 5871
Query: 311 CRVRSGPSFKSVNTSVHIYDKAFITVKH-----RKQQVLETVAGKRSYRLSMKVKAFPSP 365
C + N + +A +TV+ ++ + LE + GK S+ ++ P
Sbjct: 5872 C--------VAANVAGSDECRAVLTVQEPPSFVKEPEPLEVLPGKNVTFTSV-IRGTPPF 5922
Query: 366 EVVWLKDGLPATEKSARYLTRG--YSLIIKDVTEE---------DAGNYTILLSIKQSNV 414
+V W + AR L +G ++ +D E +G YT ++S +N
Sbjct: 5923 KVNWFR--------GARELVKGDRCNIYFEDTVAELELFNIDISQSGEYTCVVS---NNA 5971
Query: 415 FKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHN 474
+ T + +P + K +S D ++ P G IL T G ++ W N
Sbjct: 5972 GQASCTTRLFVKEPAAFLKRLS---DHSVEP-GKSIILESTYTGTLPISVTWKKDGFNIT 6027
Query: 475 HSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYI 534
SE +C+ + T++ I+E N + R +G Y
Sbjct: 6028 TSE-KCNIVT---------------------TEKTCILEILN--------STKRDAGQYS 6057
Query: 535 CIASNKVG--TVGRNISFYITDVPNGFHVNLEKMPTE-GEDLKLSCTVNKFLYRDVTWIL 591
C N+ G G +S T P F LE + G+ + L C V V+W
Sbjct: 6058 CEIENEAGRDVCGALVS---TLEPPYFVTELEPLEAAVGDSVSLQCQVAGTPEITVSWYK 6114
Query: 592 LRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKK 651
T T Y T L V++ DSG Y C+A N K
Sbjct: 6115 GDTKLRPTPEYRTYFTNNVAT--------LVFNKVNINDSGEYTCKAENSIGTAS--SKT 6164
Query: 652 EITIRDQEAP-YLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPELYT- 709
I++++ P R L D + TL C NG Q+ W+++ ++ + L T
Sbjct: 6165 VFRIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTS 6224
Query: 710 -----------------STSPSSSSSSPLSSSSSSS 728
S S S+S+PL ++SSS+
Sbjct: 6225 FVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSA 6260
Score = 55.5 bits (132), Expect = 2e-07
Identities = 136/675 (20%), Positives = 248/675 (36%), Gaps = 116/675 (17%)
Query: 90 STLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMT 149
+TL L + +A+++G Y C+ + E + + + + R E PE + +T
Sbjct: 6607 ATLQLGSPEASNSGKYICQI----KNDAGMRECSAVLTVLEPARII-----EKPEPMTVT 6657
Query: 150 EGRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISN---------ATY 199
G + C VT +P ++ K DG+ + DS+ N A
Sbjct: 6658 TGNPFALECVVTGTPELSAKWFK--------DGRELSADSKHHITFINKVASLKIPCAEM 6709
Query: 200 KEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLN 259
+ GL + E + H + I + V + G ++VL C + +
Sbjct: 6710 SDKGLYSFEVKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRVSG--S 6767
Query: 260 TRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSF 319
+ + W + N+ S + QS+ N+ L + ++ D G+YTC +
Sbjct: 6768 APISVGWF--QDGNEIVSGPKC--QSSFSENV--CTLNLSLLEPSDTGIYTCVAANVAGS 6821
Query: 320 KSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG---LPA 376
+ + + + +VL + S + ++ P +V W K +P
Sbjct: 6822 DECSAVLTVQEPPSFEQTPDSVEVLPGM----SLTFTSVIRGTPPFKVKWFKGSRELVPG 6877
Query: 377 TEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVS 436
+ L + +V ++G+Y+ L++ + + T L V +P + K ++
Sbjct: 6878 ESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSA--SCTTHLFVK-EPATFVKRLA 6934
Query: 437 SFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADS 496
F GS +L T G P ++ W + SE RC + E+S IL+
Sbjct: 6935 DFS----VETGSPIVLEATYTGTPPISVSWIKDEYLISQSE-RCSI-TMTEKSTILEI-- 6986
Query: 497 NMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDV- 555
+ + IE Q Y C+ N+ G ++I + V
Sbjct: 6987 -LESTIEDYAQ-------------------------YSCLIENEAG---QDICEALVSVL 7017
Query: 556 -PNGFHVNLEKMPTE-GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSIS-KQKMAIT 612
P F LE + GE L C V+ ++W T Y + K +A
Sbjct: 7018 EPPYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVA-- 7075
Query: 613 KEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAP-YLLRNLSDHT 671
+L I V D G Y+C+A N + + I+ ++ P + R L D
Sbjct: 7076 -------SLVINKVDHSDVGEYSCKADNSVGA--VASSAVLVIKARKLPPFFARKLKDVH 7126
Query: 672 VAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPELYTS------------TSPS----- 714
+ +C NG Q++W+K+ ++ + L TS T S
Sbjct: 7127 ETLGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTSFVHNVATLQILQTDQSHIGQY 7186
Query: 715 -SSSSSPLSSSSSSS 728
S+S+PL ++SSS+
Sbjct: 7187 NCSASNPLGTASSSA 7201
Score = 53.9 bits (128), Expect = 5e-07
Identities = 106/521 (20%), Positives = 182/521 (34%), Gaps = 108/521 (20%)
Query: 238 RPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLT 297
+ +K+L + C + P + + W D++ + + R +I + + L
Sbjct: 3065 KDIKVLEKKRAMFECEVSEP---DITVQWM-KDDQELQITDRIKIQKEK-----YVHRLL 3115
Query: 298 IDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSM 357
I + D G YT V +G + + V D ++K ++ QV+E + ++
Sbjct: 3116 IPSTRMSDAGKYT--VVAGGNVSTAKLFVEGRDVRIRSIK-KEVQVIEKQRAVVEFEVNE 3172
Query: 358 KVKAFPSPEVVWLKDGLPAT---EKSARYLT--RGYSLIIKDVTEEDAGNYTILLSIKQS 412
+ W KDG+ ++ +Y+ R + + I + + DAG YT + +S
Sbjct: 3173 D-----DVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRS 3227
Query: 413 NVFKNLTATLIVNV--KPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHP 470
+V TL VN PQ+ ++ P G G PQP I W+
Sbjct: 3228 SV------TLYVNAPEPPQVLQEL-----QPVTVQSGKPARFCAVISGRPQPKISWYKEE 3276
Query: 471 CNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS 530
+ +C F + +E +L L+ A +
Sbjct: 3277 -QLLSTGFKCKFLHDGQEYTLL-----------------------------LIEAFPEDA 3306
Query: 531 GIYICIASNKVG--TVGRNISFYITDV----------PNGFHVNLEKMPT-EGEDLKLSC 577
+Y C A N G T ++S + +V P L+ T EG+ + C
Sbjct: 3307 AVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQC 3366
Query: 578 TVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACR 637
V+ + V+W + I + + T L I +D GTY
Sbjct: 3367 RVSGTDLK-VSWY--------SKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFV 3417
Query: 638 ARN------------VYTGEEILQKK---EITIRDQEAPYLLRNLSDHTVAISSSTTLDC 682
A N + E IL ++ EI + + AP + R + VA+ C
Sbjct: 3418 ASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTC 3477
Query: 683 HANGVPEPQITWFKNNHKIQQEPELYTSTSPSSSSSSPLSS 723
P + WFK E+Y S S SS +SS
Sbjct: 3478 EIQSAPNVRFQWFKAGR------EIYESDKCSIRSSKYISS 3512
Score = 53.9 bits (128), Expect = 5e-07
Identities = 83/430 (19%), Positives = 159/430 (36%), Gaps = 61/430 (14%)
Query: 294 SVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSY 353
+ L +++ + G YTC++++ + ++ + + A I K + ++ G +
Sbjct: 7548 ATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIV---EKPESIKVTTGD-TC 7603
Query: 354 RLSMKVKAFPSPEVVWLKDGLPATEKS---ARYLTRGYSLIIKDVTEEDAGNYTILLSIK 410
L V P W KDG T + + + L I +V D+G Y+ +
Sbjct: 7604 TLECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEV--- 7660
Query: 411 QSNVFK-NLTATLIVNVK--PQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWF 467
Q+ V K + TA+L V+ + P + + + + GS ++ C YG P ++ WF
Sbjct: 7661 QNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLS----GSSVVMECKVYGSPPISVSWF 7716
Query: 468 WHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADS 527
+ GN I S + + N A T+ + +
Sbjct: 7717 -----------------------------HEGNEISSGRKYQTTLT-DNTCALTVNMLEE 7746
Query: 528 RISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDV 587
SG Y CIA+N G+ + + + P+ G ++ + V V
Sbjct: 7747 SDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSV 7806
Query: 588 TWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEI 647
+W + + + ++ E S+ L + +V SG Y C N E
Sbjct: 7807 SWF-------KGSSELVPGDRCNVSLEDSVA-ELELFDVDTSQSGEYTCIVSN-----EA 7853
Query: 648 LQKKEITIRDQEAP-YLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPE 706
+ T +AP ++ L+D+++ L+ G P +TW KN +
Sbjct: 7854 GKASCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQR 7913
Query: 707 LYTSTSPSSS 716
+T+ S+
Sbjct: 7914 CNITTTEKSA 7923
Score = 53.5 bits (127), Expect = 7e-07
Identities = 120/642 (18%), Positives = 226/642 (35%), Gaps = 95/642 (14%)
Query: 81 CGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYS 140
C + + + L L + +G Y+C + +++ + +++I + FV+ +
Sbjct: 7821 CNVSLEDSVAELELFDVDTSQSGEYTC----IVSNEAGKASCTTHLYIKAPAK-FVKRLN 7875
Query: 141 EIPEIIHMTEGRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFI--ISNA 197
+ + +G+ L++ T +P I+VT KK ++ + P + I + K I I ++
Sbjct: 7876 DYS----IEKGKPLILEGTFTGTPPISVTWKKNGIN-VTPSQRCNITTTEKSAILEIPSS 7930
Query: 198 TYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQI---------STPRPVKLLRGHTL 248
T ++ G C Y+ + QI PVK+ G +
Sbjct: 7931 TVEDAGQYNC------------YIENASGKDSCSAQILILEPPYFVKQLEPVKVSVGDSA 7978
Query: 249 VLNCT-ATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKG 307
L C A TP + ++W Y + R + ++ N+ A + ++ + I+ D G
Sbjct: 7979 SLQCQLAGTP---EIGVSW-YKGDTKLRPTTTYKMHFRNNVATLVFNQVDIN-----DSG 8029
Query: 308 LYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEV 367
Y C+ + S +T + + ++ R+ + ++ G + V
Sbjct: 8030 EYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVV-FDCAISGSEPISV 8088
Query: 368 VWLKDGLPATEK---SARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIV 424
W KDG P + +L +L I AG Y+ + + + L
Sbjct: 8089 SWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTE 8148
Query: 425 NVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCS 484
P ++ ++ P +G C G + W ++R
Sbjct: 8149 GKNPPFFDIRLA----PVDAVVGESADFECHVTGTQPIKVSWA--------KDSR----- 8191
Query: 485 NNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTV 544
+ G + + I +N T++ D SG Y C A N+VG
Sbjct: 8192 ----------EIRSGGKYQ-------ISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKD 8234
Query: 545 GRNISFYITD--VPNGFHVNLEKM--PTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM 600
I + +P F L + TEG KL V V W T
Sbjct: 8235 SCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTS 8294
Query: 601 HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEA 660
+ I+ + TL L + + D+G Y C+ N G + + ++
Sbjct: 8295 NCEITFKNN--------TLVLQVRKAGMNDAGLYTCKVSND-AGSALCTSSIVIKEPKKP 8345
Query: 661 PYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQ 702
P ++L+ TV+ L CH G +I W K +I+
Sbjct: 8346 PVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIK 8387
Score = 52.4 bits (124), Expect = 2e-06
Identities = 90/430 (20%), Positives = 159/430 (36%), Gaps = 56/430 (13%)
Query: 283 DQSNSHANIFYSVLTIDKMQNKDK--GLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRK 340
D +N + ++V T+ +Q G Y C S P + +++ I + +
Sbjct: 7158 DDANLQTSFVHNVATLQILQTDQSHIGQYNCSA-SNPLGTASSSAKLILSEHEVPPFFDL 7216
Query: 341 QQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGL---PATEKSARYLTRGYSLIIKDVTE 397
+ V +A S V ++ W KD P + +L + V +
Sbjct: 7217 KPVSVDLALGESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGK 7276
Query: 398 EDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAY 457
DAG YT S + +A L V P+ +K S + C
Sbjct: 7277 GDAGQYTCYASNIAGK--DSCSAQLGVQEPPRFIKKLEPS----RIVKQDEFTRYECKIG 7330
Query: 458 GIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNK 517
G P+ + W+ +E+ I ++ + ++S+ A++E N
Sbjct: 7331 GSPEIKVLWY------------------KDETEIQESSKFRMSFVDSV----AVLEMHN- 7367
Query: 518 MASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPT-EGEDLKLS 576
L V DS G Y C A N G+ + S + + P F + T +G D+ L
Sbjct: 7368 ----LSVEDS---GDYTCEAHNAAGSASSSTSLKVKEPPI-FRKKPHPIETLKGADVHLE 7419
Query: 577 CTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYAC 636
C + V+W + R + S +K I E+ +T ++ I+NV D G Y C
Sbjct: 7420 CELQGTPPFHVSWYK----DKRELR---SGKKYKIMSENFLT-SIHILNVDAADIGEYQC 7471
Query: 637 RARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFK 696
+A N + + +I + P ++ LSD + + L G + WFK
Sbjct: 7472 KATNDVGSDTCVG----SIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFK 7527
Query: 697 NNHKIQQEPE 706
+ +I +E +
Sbjct: 7528 DKGEIVRESD 7537
Score = 52.0 bits (123), Expect = 2e-06
Identities = 142/665 (21%), Positives = 244/665 (36%), Gaps = 112/665 (16%)
Query: 90 STLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMT 149
S+L L + + +G Y+CK V E + +F+ + FVE E +++
Sbjct: 4261 SSLELYLVKTSDSGTYTCKVSNVAGG----VECSANLFVKEPAT-FVEKL-EPSQLLKKG 4314
Query: 150 EGRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYK-------E 201
+ +L C+VT +P I +T F D I + + R F+ S A + +
Sbjct: 4315 DATQLA--CKVTGTPPIKITW--FANDREIKESSK----HRMSFVESTAVLRLTDVGIED 4366
Query: 202 IGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTP-----RPVKLLRGHTLVLNC-TAT 255
G CEA N ++I+ V+ S +P+++L+ + ++L A
Sbjct: 4367 SGEYMCEAQ--------NEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLAEVAG 4418
Query: 256 TPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS 315
TP ++TW K ++ R + + L I K D G Y CRV +
Sbjct: 4419 TP---PFEITWF------KDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTN 4469
Query: 316 GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLP 375
+ V + + K L G +++ ++K + P V WLKD
Sbjct: 4470 EVGSSICSARVTLREPPSFIKKIESTSSLR--GGTAAFQATLK-GSLPIT-VTWLKDSDE 4525
Query: 376 ATEKSARYLT---RGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYE 432
TE +T SL + + + G Y + K + +A L V I E
Sbjct: 4526 ITEDDNIRMTFENNVASLYLSGIEVKHDGKY--VCQAKNDAGIQRCSALLSVKEPATITE 4583
Query: 433 KAVS---SFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEES 489
+AVS + DPA L G + T KWF + +E
Sbjct: 4584 EAVSIDVTQGDPAT--------LQVKFSGTKEITAKWF----------------KDGQEL 4619
Query: 490 FILDADSNMGNRIE-SITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNI 548
+G++ + S+T ++I++ ++ + + SG Y N VG
Sbjct: 4620 -------TLGSKYKISVTDTVSILK--------IISTEKKDSGEYTFEVQNDVGRSSCKA 4664
Query: 549 SFYITD--VPNGFHVNLEKMPT-EGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSIS 605
+ D +P F L+KM + +G + L C V + W + + Y S
Sbjct: 4665 RINVLDLIIPPSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQWFKDDQEISASEKYKFS 4724
Query: 606 KQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLR 665
H T L I + DSGTY C A N + +T++ E PY +
Sbjct: 4725 F--------HDNTAFLEISQLEGTDSGTYTCSATNKAGHNQC--SGHLTVK--EPPYFVE 4772
Query: 666 NLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPELYTSTSPSSSSSSPLSSSS 725
V ++ L G I WFK+N ++ +S+S ++ +
Sbjct: 4773 KPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKA 4832
Query: 726 SSSSS 730
+ S +
Sbjct: 4833 TDSGT 4837
Score = 52.0 bits (123), Expect = 2e-06
Identities = 129/646 (19%), Positives = 222/646 (34%), Gaps = 106/646 (16%)
Query: 90 STLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMT 149
+TL + +H+G YSC + + SA PF ++ P I +
Sbjct: 6230 ATLKILQTDLSHSGQYSC---SASNPLGTASSSARLTAREPKKSPFFDIK---PVSIDVI 6283
Query: 150 EGRELVIPCRVTSPN-ITVTLKKFPLDTLIPDGKRIIW--DSRKGFIISNATYKEIGLLT 206
G C VT + +T K + + P G I + I + G T
Sbjct: 6284 AGESADFECHVTGAQPMRITWSKDNKE-IRPGGNYTITCVGNTPHLRILKVGKGDSGQYT 6342
Query: 207 CEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLR----------GHTLVLNCTATT 256
C+AT + + Q+S P K ++ G ++ L C +
Sbjct: 6343 CQAT------------NDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKISG 6390
Query: 257 PLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSG 316
+ ++++W + ++ S + + NS A +LTI++ +D G Y C +G
Sbjct: 6391 --SPEIKVSW-FRNDSELHESWKYNMSFINSVA-----LLTINEASAEDSGDYICEAHNG 6442
Query: 317 PSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPA 376
S +T++ + T K L+ L ++ P EVVW+KD
Sbjct: 6443 VGDASCSTALTVKAPPVFTQKPSPVGALKG----SDVILQCEISGTPPFEVVWVKDRKQV 6498
Query: 377 TEKSARYLTRGY---SLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEK 433
+T + SL I ++ D G Y K +N + T + V K +
Sbjct: 6499 RNSKKFKITSKHFDTSLHILNLEASDVGEY----HCKATNEVGSDTCSCSVKFKEP--PR 6552
Query: 434 AVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILD 493
V D + +G L G ++ W + I +
Sbjct: 6553 FVKKLSDTSTL-IGDAVELRAIVEGFQPISVVWL-----------------KDRGEVIRE 6594
Query: 494 ADSNMGNRIESI-TQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYI 552
+++ + I++I T ++ E N SG YIC N G R S +
Sbjct: 6595 SENTRISFIDNIATLQLGSPEASN-------------SGKYICQIKNDAGM--RECSAVL 6639
Query: 553 TDV-PNGFHVNLEKMP-TEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMA 610
T + P E M T G L C V W + ++ A
Sbjct: 6640 TVLEPARIIEKPEPMTVTTGNPFALECVVTGTPELSAKW------------FKDGRELSA 6687
Query: 611 ITKEHSITLN----LTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRN 666
+K H +N L I + D G Y+ +N ++ R P +R
Sbjct: 6688 DSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIVP-PSFIRK 6746
Query: 667 LSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPELYTSTS 712
L D + +S L+C +G + WF++ ++I P+ +S S
Sbjct: 6747 LKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFS 6792
Score = 52.0 bits (123), Expect = 2e-06
Identities = 106/534 (19%), Positives = 181/534 (33%), Gaps = 122/534 (22%)
Query: 250 LNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSV-----LTIDKMQNK 304
L C + + ++TW Y D K + N H YS L I+ +
Sbjct: 32735 LTCVVESSVLRAKEVTW-YKDGKKLK---------ENGHFQFHYSADGTYELKINNLTES 32784
Query: 305 DKGLYTCRVRS------------GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRS 352
D+G Y C + G +FKS++ V K T K ++ TV K
Sbjct: 32785 DQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKV---SKISETKKSDQKTTESTVTRKTE 32841
Query: 353 ---------------------------YRLSMKVKAFPSPEVVWLKDGLPATEKSARYLT 385
+ ++K P P +W KDG T+ L+
Sbjct: 32842 PKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLS 32901
Query: 386 R---GYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPA 442
G+ L I D+G YT ++K S + + L + + VS+
Sbjct: 32902 EDKGGFFLEIHKTDTSDSGLYTC--TVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSE 32959
Query: 443 LYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRI 502
+ P Q I Q ++ +EE + +A S
Sbjct: 32960 ITP----QKKAVVQEEISQKALR--------------------SEEIKMSEAKSQ----- 32990
Query: 503 ESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVN 562
+++A+ E +K+ + V S + + I ++ + T H
Sbjct: 32991 ----EKLALKEEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRT------HAE 33040
Query: 563 LEKMPTE---GEDLKLSCTVNKFLYRDVTWIL--LRTVNNRTMHYSISKQKMAITKEHSI 617
++ T+ E +L N DV W+L + N+ Y +S
Sbjct: 33041 IKAFSTQMSINEGQRLVLKANIAGATDVKWVLNGVELTNSEEYRYGVSGSDQT------- 33093
Query: 618 TLNLTIMNVSLQDSGTYACRARNVYTGEEILQ-KKEITIRDQ--EAPYLLRNLSDHTVAI 674
LTI S +D G C ++ T E I++ + ++T+ + +AP + +
Sbjct: 33094 ---LTIKQASHRDEGILTCISK---TKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINE 33147
Query: 675 SSSTTLDCHANGVPEPQITWFKNNHKIQQEPELYTSTSPSSSSSSPLSSSSSSS 728
+ C +G P P+I WFKNN I + S S + S ++S S S
Sbjct: 33148 GQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDS 33201
Score = 52.0 bits (123), Expect = 2e-06
Identities = 81/363 (22%), Positives = 143/363 (39%), Gaps = 63/363 (17%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKS----VNTSVHIYDKAFITVKHRKQQVLETVAGKR 351
LTI + ++D+G+ TC ++ + S + D + R Q + E +
Sbjct: 33094 LTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEG----Q 33149
Query: 352 SYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRG---YSLIIKDVTEEDAGNYTILLS 408
+ + ++ PSPE+ W K+ LP + S ++R YSL I++ + D+G YT
Sbjct: 33150 NVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYT---- 33205
Query: 409 IKQSNVFKNLTATLIVNVKPQIYEKA----VSSFPDPALYPLGSRQILTCTAYGIPQPTI 464
IK N +AT + V P + E + + + D +L S Q + +A
Sbjct: 33206 IKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSA-------- 33257
Query: 465 KWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVV 524
S E SF + S+ + E M+ + S + +
Sbjct: 33258 -------------------SKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEM 33298
Query: 525 ADSRISGI----YICIASNKVGTVG-RNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTV 579
+ S GI + +++K+ G R I I +P+ ++ EG+ L ++C
Sbjct: 33299 SSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISID------EGKVLTVACAF 33352
Query: 580 NKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRAR 639
+VTW + R +H S + + I +T L IM+V QD G Y
Sbjct: 33353 TGEPTPEVTW----SCGGRKIH-SQEQGRFHIENTDDLT-TLIIMDVQKQDGGLYTLSLG 33406
Query: 640 NVY 642
N +
Sbjct: 33407 NEF 33409
Score = 51.2 bits (121), Expect = 3e-06
Identities = 52/176 (29%), Positives = 77/176 (43%), Gaps = 15/176 (8%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
L I +Q D G YTC +R G K+ + + + VK +++V TV + L
Sbjct: 11175 LHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVEELPVRFVKTLEEEV--TVVKGQPLYL 11232
Query: 356 SMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLI----IKDVTEEDAGNYTILLSIKQ 411
S ++ +VVW KDG EK R + L+ I D + DAG YT+ +++
Sbjct: 11233 SCELN--KERDVVWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGTYTV--TVEN 11288
Query: 412 SNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWF 467
+N NL + V V I + V D + P G+ I C P IKWF
Sbjct: 11289 AN---NLECSSCVKVVEVIRDWLVKPIRDQHVKPKGT-AIFACD-IAKDTPNIKWF 11339
Score = 50.4 bits (119), Expect = 6e-06
Identities = 97/446 (21%), Positives = 173/446 (38%), Gaps = 63/446 (14%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRK---QQVLETVAGKRS 352
L I K D GLYTC V++ S SV++S + KA + +K Q+ E K++
Sbjct: 32909 LEIHKTDTSDSGLYTCTVKN--SAGSVSSSCKLTIKAIKDTEAQKVSTQKTSEITPQKKA 32966
Query: 353 Y-RLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQ 411
+ + KA S E+ + + EK A LI ++V + A S+++
Sbjct: 32967 VVQEEISQKALRSEEIKMSE--AKSQEKLALKEEASKVLISEEVKKSAA------TSLEK 33018
Query: 412 SNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPC 471
S V + +T T + + + + + + +F G R +L G +KW +
Sbjct: 33019 SIVHEEITKTSQASEEVRTHAE-IKAFSTQMSINEGQRLVLKANIAGATD--VKWVLNGV 33075
Query: 472 NHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISG 531
+SE S ++++ T+ A R G
Sbjct: 33076 ELTNSEEYRYGVSGSDQTL------------------------------TIKQASHRDEG 33105
Query: 532 IYICIASNKVGTV----GRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDV 587
I CI+ K G V +S ++D P + EG+++ +C ++ ++
Sbjct: 33106 ILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEI 33165
Query: 588 TWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEI 647
W + SIS ++I++ ++ +L I N S+ DSG Y +A+N + G+
Sbjct: 33166 EWF------KNNLPISISSN-VSISRSRNV-YSLEIRNASVSDSGKYTIKAKN-FRGQCS 33216
Query: 648 LQKKEITIRDQEAP---YLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE 704
+ + E P +LR D ++ S S+ + E + F ++
Sbjct: 33217 ATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFSSSSASSMT 33276
Query: 705 PELYTSTSPSSSSSSPLSSSSSSSSS 730
+ S S S SS S SSSS
Sbjct: 33277 EMKFASMSAQSMSSMQESFVEMSSSS 33302
Score = 49.7 bits (117), Expect = 1e-05
Identities = 142/680 (20%), Positives = 245/680 (36%), Gaps = 118/680 (17%)
Query: 70 ESERLSITKSACGRN---GKQF-------CSTLTLNTAQANHTGFYSCKYLAVPTSKKKE 119
E ++++T S G+ GK + +TL + A+ +G Y C T+ +
Sbjct: 3669 EDRKVTVTWSKDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYVC------TASNEA 3722
Query: 120 TESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVT-SPNITVTLKKFPLDTLI 178
S+ ++ P ++ M G + C++ SP I VT K +
Sbjct: 3723 GSSSCSATVTVREPP--SFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNNKELSE 3780
Query: 179 PDGKRIIWDSRKGFI-ISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQ---- 233
+ R+ + + + + I++ ++ G +CEA N + +T I ++
Sbjct: 3781 SNTVRMYFVNSEAILDITDVKVEDSGSYSCEAV--------NDVGSDSCSTEIVIKEPPS 3832
Query: 234 -ISTPRPVKLLRGHTLVLNC--TATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHAN 290
I T P ++RG +L C + T P +++W + D+K R+S + R+ S
Sbjct: 3833 FIKTLEPADIVRGTNALLQCEVSGTGPF----EISW-FKDKKQIRSSKKYRLFSQKSLV- 3886
Query: 291 IFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVA-G 349
L I + D G Y C V + K + H+ + VK +V + +A G
Sbjct: 3887 ----CLEIFSFNSADVGEYECVVANEVG-KCGCMATHLLKEPPTFVK----KVDDLIALG 3937
Query: 350 KRSYRLSMKVKAFPSPEVVWLKDGLPATE--KSARYLTRGYS-LIIKDVTEEDAGNYTIL 406
++ L V+ V W+K E K + G + LII DV G YT L
Sbjct: 3938 GQTVTLQAAVRGSEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCL 3997
Query: 407 LSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKW 466
+ + + LIV +I E+A + G L T G P+ KW
Sbjct: 3998 AENEAGS--QTSVGELIVKEPAKIIERA-----ELIQVTAGDPATLEYTVAGTPELKPKW 4050
Query: 467 FWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMAST-LVVA 525
+ + R + + I KN +A A
Sbjct: 4051 Y--------KDGR-----------------------PLVASKKYRISFKNNVAQLKFYSA 4079
Query: 526 DSRISGIYICIASNKVGTVGRNISFYITD--VPNGFHVNLEKMPTE-GEDLKLSCTVNKF 582
+ SG Y SN+VG+ +F + D + F L + + +L C +
Sbjct: 4080 ELHDSGQYTFEISNEVGSSSCETTFTVLDRDIAPFFTKPLRNVDSVVNGTCRLDCKIAGS 4139
Query: 583 LYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSI-----TLNLTIMNVSLQDSGTYACR 637
L V+W +++A + + I T +L I+ V + D+G + CR
Sbjct: 4140 LPMRVSWFK-------------DGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNFTCR 4186
Query: 638 ARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKN 697
A N ++ + QE P + V S+ L G I WFK
Sbjct: 4187 ATNSVGSKD----SSGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKG 4242
Query: 698 NHKIQQEPELYTSTSPSSSS 717
N ++ Y + SS
Sbjct: 4243 NKELVSGGSCYITKEALESS 4262
Score = 49.3 bits (116), Expect = 1e-05
Identities = 99/479 (20%), Positives = 177/479 (36%), Gaps = 67/479 (13%)
Query: 90 STLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMT 149
+TL N N +G Y CK + E ++ ++ + + P +S + T
Sbjct: 8016 ATLVFNQVDINDSGEYICK----AENSVGEVSASTFLTVQEQKLP--PSFSRQLRDVQET 8069
Query: 150 EGRELVIPCRVT-SPNITVTLKKF--PLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLT 206
G +V C ++ S I+V+ K PL P+ + D+ I G +
Sbjct: 8070 VGLPVVFDCAISGSEPISVSWYKDGKPLKDS-PNVQTSFLDNTATLNIFKTDRSLAGQYS 8128
Query: 207 CEATV---NGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNC--TATTPLNTR 261
C AT + LT + D++++ PV + G + C T T P
Sbjct: 8129 CTATNPIGSASSSARLILTEGKNPPFFDIRLA---PVDAVVGESADFECHVTGTQP---- 8181
Query: 262 VQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKS 321
++++W+ D + R+ + +I + A+ LT+ K+ D G YTC + S
Sbjct: 8182 IKVSWA-KDSREIRSGGKYQISYLENSAH-----LTVLKVDKGDSGQYTCYAVNEVGKDS 8235
Query: 322 VNTSVHIYDKAF-ITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGL---PAT 377
++I ++ + R + +E G S++L +V V W K+ + P +
Sbjct: 8236 CTAQLNIKERLIPPSFTKRLSETVEETEG-NSFKLEGRVAGSQPITVAWYKNNIEIQPTS 8294
Query: 378 EKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSS 437
+ L ++ DAG YT +S + + + KP ++++ ++
Sbjct: 8295 NCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLT- 8353
Query: 438 FPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSN 497
P G L+C G I+W S+ RC F
Sbjct: 8354 ---PVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSD-RCSF--------------- 8394
Query: 498 MGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVP 556
S A++E ++ + AD SG Y+C ASN G+ I D P
Sbjct: 8395 ------SFASGTAVLELRD-----VAKAD---SGDYVCKASNVAGSDTTKSKVTIKDKP 8439
Score = 45.4 bits (106), Expect = 2e-04
Identities = 99/483 (20%), Positives = 180/483 (37%), Gaps = 66/483 (13%)
Query: 6 DTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIM--QAGQTLHLQCRGEAAHKWSL 63
D+G +C L + + S + +K+P +K ++ + GQ+ +C+ K
Sbjct: 4834 DSGTYICQLSNDVGTATSKATLFVKEPPQFIKKPSPVLVLRNGQSTTFECQITGTPKIR- 4892
Query: 64 PEMVSKESERLSITKSACGRNGKQFC---STLTLNTAQANHTGFYSCKYLAVPTSKKKET 120
VS + IT A ++G F +T ++ A+ ++G Y C+ +
Sbjct: 4893 ---VSWYLDGNEIT--AIQKHGISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSI 4947
Query: 121 ESAIY---IFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVT-SPNITVTLKKFPLDT 176
E + FI + V YS++ + C VT +P VT K
Sbjct: 4948 ELKVKEPPTFIRELKPVEVVKYSDVE------------LECEVTGTPPFEVTWLK----- 4990
Query: 177 LIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQIST 236
R I S+K + + + + C+ + G Y+ +++ + +++
Sbjct: 4991 ----NNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGE-YQC-IVSNEGGSCSCSTRVAL 5044
Query: 237 PRP---VKLLRGHTLVLNCTATTPLNTR----VQMTWSYPDEKNKRASVRRRIDQSNSHA 289
P +K + T VL +AT + +TW D+ + N +
Sbjct: 5045 KEPPSFIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQILD--------EDDNVYI 5096
Query: 290 NIFYSVLTID--KMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETV 347
+ SV T+ + N G YTC+ ++ + + + + A I K + V E
Sbjct: 5097 SFVDSVATLQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQIVEKAKSVDVTE-- 5154
Query: 348 AGKRSYRLSMKVKAFPSPEVVWLKDG---LPATEKSARYLTRGYSLIIKDVTEEDAGNYT 404
K L V P +V WLKDG +P+ S + S I+ V ++D+G YT
Sbjct: 5155 --KDPMTLECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYT 5212
Query: 405 ILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTI 464
K N F + + + V Q + + LGS + C G +
Sbjct: 5213 ----FKVENDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISA 5268
Query: 465 KWF 467
+WF
Sbjct: 5269 QWF 5271
Score = 44.3 bits (103), Expect = 4e-04
Identities = 27/121 (22%), Positives = 59/121 (48%), Gaps = 3/121 (2%)
Query: 611 ITKEHSITLNLTIMNVSLQDSGTYACRARNVY-TGEEILQKKEITIRDQEAPYLLR-NLS 668
+T ++ ++ T+ + D+ Y A N+ G+ K IT +D+ AP L +
Sbjct: 16766 VTNDNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFR 16825
Query: 669 DH-TVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPELYTSTSPSSSSSSPLSSSSSS 727
D T+ + + L +G P+P+++WFK+ + ++ + T+P++ + + + S
Sbjct: 16826 DKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSD 16885
Query: 728 S 728
S
Sbjct: 16886 S 16886
Score = 43.9 bits (102), Expect = 5e-04
Identities = 28/82 (34%), Positives = 39/82 (47%), Gaps = 5/82 (6%)
Query: 346 TVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKD-VTEEDAGNYT 404
T+ S RL + V P P + W K G+ ++ T YSL+I D V DAG YT
Sbjct: 29457 TIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYT 29516
Query: 405 ILLSIKQSNVFKNLTATLIVNV 426
I+ N +AT++V V
Sbjct: 29517 ----IEAENQSGKKSATVLVKV 29534
Score = 43.5 bits (101), Expect = 7e-04
Identities = 85/441 (19%), Positives = 158/441 (35%), Gaps = 81/441 (18%)
Query: 295 VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYR 354
VL + K D GLYTC+V + +S+ I + V + + TV+ +
Sbjct: 8306 VLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPV-TVSEGEYVQ 8364
Query: 355 LSMKVKAFPSPEVVWLKDG---LPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQ 411
LS V+ + WLK G P+ S + + L ++DV + D+G+Y K
Sbjct: 8365 LSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYV----CKA 8420
Query: 412 SNVFKNLTATLIVNV--KPQIYEKAVSSFPDPALY----PLGSRQILTCTAY------GI 459
SNV + T V + KP + + D L+ P R + TA G
Sbjct: 8421 SNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGD 8480
Query: 460 PQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMA 519
P P +KW + R +E+ + D+ +
Sbjct: 8481 PIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTD------------------- 8521
Query: 520 STLVVADSRISGIYICIASNKVGTVGRNISFYITD------VPNGFHVNLEKMPT----E 569
SG+Y C+A N+ G + N++ + + + L+K P
Sbjct: 8522 ----------SGLYRCVAFNEHGEIESNVNLQVDERKKQEKIEGDLRAMLKKTPILKKGA 8571
Query: 570 GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQ 629
GE+ ++ LL+ V+ + Y + IT + ++ S Q
Sbjct: 8572 GEEEEIDIME-----------LLKNVDPK--EYEKYARMYGITDFRGLLQAFELLKQS-Q 8617
Query: 630 DSGTYACRARNVYTG-------EEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDC 682
+ T+ + EE++ + + E L++++ + TV + +
Sbjct: 8618 EEETHRLEIEEIERSERDEKEFEELVSFIQQRLSQTEPVTLIKDIENQTVLKDNDAVFEI 8677
Query: 683 HAN-GVPEPQITWFKNNHKIQ 702
PE +++W+K K++
Sbjct: 8678 DIKINYPEIKLSWYKGTEKLE 8698
Score = 43.5 bits (101), Expect = 7e-04
Identities = 56/214 (26%), Positives = 85/214 (39%), Gaps = 26/214 (12%)
Query: 499 GNRIESITQRMAIIEGKNKMASTLVVADSRIS--GIYICIA--SNKVGTVGRNISFYITD 554
G+ I + I +GK++ L + D ++S G Y C+ NK T + +
Sbjct: 11155 GSNIRESPKHRFIADGKDRK---LHIIDVQLSDAGEYTCVLRLGNKEKT--STAKLVVEE 11209
Query: 555 VPNGFHVNLEKMPT--EGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAIT 612
+P F LE+ T +G+ L LSC +NK RDV W + + K +
Sbjct: 11210 LPVRFVKTLEEEVTVVKGQPLYLSCELNK--ERDVVW-------RKDGKIVVEKPGRIVP 11260
Query: 613 KEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEI-TIRDQEAPYLLRNLSDHT 671
+ LTI + D+GTY N E K + IRD +L++ + D
Sbjct: 11261 GVIGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKVVEVIRD----WLVKPIRDQH 11316
Query: 672 VAISSSTTLDCHANGVPEPQITWFKNNHKIQQEP 705
V + C P I WFK +I EP
Sbjct: 11317 VKPKGTAIFACDI-AKDTPNIKWFKGYDEIPAEP 11349
Score = 43.1 bits (100), Expect = 0.001
Identities = 16/42 (38%), Positives = 27/42 (64%)
Query: 661 PYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQ 702
P L+ L + TV S TL+CH +G P P +TW++ +++I+
Sbjct: 943 PTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIE 984
Score = 42.7 bits (99), Expect = 0.001
Identities = 124/626 (19%), Positives = 221/626 (35%), Gaps = 105/626 (16%)
Query: 121 ESAIYIFISDTGRPFVEMYSEIPEI--------IHMTEGRELVIPCRVTSPNITVTLKKF 172
++A Y F++ +Y E I I + E + + C V+ P+ITV K
Sbjct: 3034 DAADYTFVAGKATSTATLYVEARHIEFRKHIKDIKVLEKKRAMFECEVSEPDITVQWMKD 3093
Query: 173 PLDTLIPDGKRIIWDSR-KGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIID 231
+ I D +I + +I + + G T A N K ++ R D
Sbjct: 3094 DQELQITDRIKIQKEKYVHRLLIPSTRMSDAGKYTVVAGGNVSTAKL-FVEGR------D 3146
Query: 232 VQI-STPRPVKLLRGHTLVLNCTATTPLNTRVQMTW-------SYPDEKNKRASVRRRID 283
V+I S + V+++ V+ V W ++ ++ + V RRI
Sbjct: 3147 VRIRSIKKEVQVIEKQRAVVEFEVN---EDDVDAHWYKDGIEINFQVQERHKYVVERRIH 3203
Query: 284 QSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQV 343
+ + I + + D G YT S SV +Y A + ++
Sbjct: 3204 R-----------MFISETRQSDAGEYTFVAGRNRS------SVTLYVNAPEPPQVLQELQ 3246
Query: 344 LETVAGKRSYRLSMKVKAFPSPEVVWLKDG-LPATEKSARYLTRG--YSLIIKDVTEEDA 400
TV + R + P P++ W K+ L +T ++L G Y+L++ + EDA
Sbjct: 3247 PVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDA 3306
Query: 401 GNYTILLSIKQSNVFKNLTATLIVNVKPQIY--EKAVSSFPDPALYPLGSRQILTCTAYG 458
YT K +A+L V V P++ ++ + +P + PL T T+ G
Sbjct: 3307 AVYTC--EAKNDYGVATTSASLSVEV-PEVVSPDQEMPVYPPAIITPLQD----TVTSEG 3359
Query: 459 IPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKM 518
P C + ++ + + S +++ +R +TQ ++
Sbjct: 3360 QPAR------FQCRVSGTDLKVSWYSKDKKI--------KPSRFFRMTQF------EDTY 3399
Query: 519 ASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKM------------ 566
+ A G Y +ASN VG V + + + H +E+
Sbjct: 3400 QLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIK 3459
Query: 567 ----PTE---GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITL 619
P E G K +C + W R ++ S K +I I+
Sbjct: 3460 RKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKA----GREIYES---DKCSIRSSKYIS- 3511
Query: 620 NLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTT 679
+L I+ + D G Y C+A N Y + +T+ + P L T + +
Sbjct: 3512 SLEILRTQVVDCGEYTCKASNEY--GSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAK 3569
Query: 680 LDCHANGVPEPQITWFKNNHKIQQEP 705
C G P + W K+ + P
Sbjct: 3570 FICTVTGTPVIETIWQKDGAALSPSP 3595
Score = 41.2 bits (95), Expect = 0.003
Identities = 76/320 (23%), Positives = 134/320 (41%), Gaps = 60/320 (18%)
Query: 128 ISDTGRPFVEMYSEIPEI--IHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGK-RI 184
+S +GR V I + +++ EG + V+ C+V+ P++T + + PD + +
Sbjct: 2434 LSTSGRVSVYSVDVITPLKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQA 2493
Query: 185 IWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLR 244
I K ++ N T+ A+ G YK + +TN + V+ +K++R
Sbjct: 2494 IVKGTKQRLVINRTH---------ASDEGP-YKL-IVGRVETNCNLSVE-----KIKIIR 2537
Query: 245 GHTLVLNCTATTPLNTRVQMT-------WSYPDEKNKRASVRRRIDQSNSHANIFYSVLT 297
G L CT T + V+++ W++ D++ K +S + +I+ +H I+ LT
Sbjct: 2538 G-LRDLTCTETQNVVFEVELSHSGIDVLWNFKDKEIKPSS-KYKIE---AHGKIY--KLT 2590
Query: 298 IDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSM 357
+ M D+G YT + + + K +TVA +
Sbjct: 2591 VLNMMKDDEGKYTFYAGENMTSGKLTVAGGAISKPLTD---------QTVAESQEAVFEC 2641
Query: 358 KVKAFPSPEVVWLKDG--LPATEKSARYLTRGYS--LIIKDVTEEDAGNYTILL------ 407
+V A P + WL+DG LP T + R + G+ LII +D G YT +
Sbjct: 2642 EV-ANPDSKGEWLRDGKHLPLT-NNIRSESDGHKRRLIIAATKLDDIGEYTYKVATSKTS 2699
Query: 408 ------SIKQSNVFKNLTAT 421
++K KNLT T
Sbjct: 2700 AKLKVEAVKIKKTLKNLTVT 2719
Score = 41.2 bits (95), Expect = 0.003
Identities = 48/191 (25%), Positives = 78/191 (40%), Gaps = 24/191 (12%)
Query: 236 TPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRID------QSNSHA 289
T PVK + + + T V ++W+ PD ++ Q+ SHA
Sbjct: 27453 TTEPVKAAEVPAPIRDLSMKDSTKTSVILSWTKPDFDGGSVITEYVVERKGKGEQTWSHA 27512
Query: 290 NIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKH---RKQQVLET 346
I I+ Q K++ + RV + + K ++ V I ITVK + L
Sbjct: 27513 GIS-KTCEIEVSQLKEQSVLEFRVFA-KNEKGLSDPVTIGP---ITVKELIITPEVDLSD 27567
Query: 347 VAGKR-------SYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTR---GYSLIIKDVT 396
+ G + + L + K P P + WLKDGLP E ++ +L IK+
Sbjct: 27568 IPGAQVTVRIGHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAK 27627
Query: 397 EEDAGNYTILL 407
+E G YT++L
Sbjct: 27628 KEHGGKYTVIL 27638
Score = 40.0 bits (92), Expect = 0.008
Identities = 44/164 (26%), Positives = 68/164 (41%), Gaps = 16/164 (9%)
Query: 314 RSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGK----RSYRLSMKVKAFPSPEVVW 369
R P+ S + D++ + ++ VL+ V+ K ++ R +KV P PE W
Sbjct: 1431 RMSPARMSPGRRLEETDESQLERLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFW 1490
Query: 370 LKDGLPA----TEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIK--QSNVFKNLTATLI 423
DG T K SLII T D+G +T++ + +S++ LT +
Sbjct: 1491 FHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAV 1550
Query: 424 VN-VKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKW 466
+ VKP EK + GSR + A G P P I W
Sbjct: 1551 EHQVKPMFVEKLKN-----VNIKEGSRLEMKVRATGNPNPDIVW 1589
Score = 38.5 bits (88), Expect = 0.022
Identities = 23/72 (31%), Positives = 37/72 (51%), Gaps = 5/72 (6%)
Query: 341 QQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRG----YSLIIKDVT 396
+ V+ AG+ ++ L ++ P P+VVW KDG E +AR + +L++KD
Sbjct: 24714 KDVIVVHAGE-TFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCI 24772
Query: 397 EEDAGNYTILLS 408
D G Y + LS
Sbjct: 24773 RTDGGQYILKLS 24784
Score = 37.4 bits (85), Expect = 0.050
Identities = 30/114 (26%), Positives = 57/114 (50%), Gaps = 12/114 (10%)
Query: 346 TVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYS-LIIKDVTEEDAGNYT 404
T+ + RL + +K P+PEV W +D + +K++ T Y+ LI+ +V D+G Y
Sbjct: 21871 TIRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSYTLLIVGNVNRFDSGKY- 21929
Query: 405 ILLSIKQSNVFKNLTATLIVNVKP---------QIYEKAVSSFPDPALYPLGSR 449
+L+++ S+ K+ + V P ++ + +V+ DP L GS+
Sbjct: 21930 -ILTVENSSGSKSAFVNVRVLDTPGPPQDLKVKEVTKTSVTLTWDPPLLDGGSK 21982
Score = 37.4 bits (85), Expect = 0.050
Identities = 35/139 (25%), Positives = 51/139 (36%), Gaps = 11/139 (7%)
Query: 570 GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQ 629
GE +LSC + D+ W ++ Y +S T LT+M +
Sbjct: 30547 GEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHT--------LTVMTEEQE 30598
Query: 630 DSGTYACRARNVYTGEEILQKKEITIRDQEAP-YLLRNLSDHTVAISSSTTLDCHANGVP 688
D G Y C A N E K + Q P Y L+ + A+ S+ L G P
Sbjct: 30599 DEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLK--EKYYGAVGSTLRLHVMYIGRP 30656
Query: 689 EPQITWFKNNHKIQQEPEL 707
P +TWF +Q +
Sbjct: 30657 VPAMTWFHGQKLLQNSENI 30675
Score = 37.0 bits (84), Expect = 0.065
Identities = 30/114 (26%), Positives = 48/114 (42%), Gaps = 9/114 (7%)
Query: 359 VKAFPSPEVVWLKDGLPATEKSARYLTRGYS-----LIIKDVTEEDAGNYTILLSIKQSN 413
+ FP PEV W +DG + + + +S L I VT+ ++G Y S+K +N
Sbjct: 29 ISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRY----SLKATN 84
Query: 414 VFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWF 467
T+T + VK + GS+ L GIP P +K++
Sbjct: 85 GSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFY 138
Score = 37.0 bits (84), Expect = 0.065
Identities = 20/57 (35%), Positives = 34/57 (59%), Gaps = 4/57 (7%)
Query: 354 RLSMKVKAFPSPEVVWLKDGLPATEKSARYLT---RGYSLIIKDVTEEDAGNYTILL 407
+L +KV + S E VW+KDG ++ + + L+I+D+T+EDAGNY+ +
Sbjct: 2374 QLEVKV-SLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTI 2429
Score = 37.0 bits (84), Expect = 0.065
Identities = 29/143 (20%), Positives = 54/143 (37%), Gaps = 10/143 (6%)
Query: 570 GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQ 629
GE+++ T+ VTW + + + + +K + + LTI +V+
Sbjct: 31704 GENVRFGVTITVHPEPHVTWYK----SGQKIKPGDNDKKYTFESDKGL-YQLTINSVTTD 31758
Query: 630 DSGTYACRARNVYTGEEILQKKEITIRDQEA-----PYLLRNLSDHTVAISSSTTLDCHA 684
D Y ARN Y + K +T+ P R L++ S +
Sbjct: 31759 DDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRV 31818
Query: 685 NGVPEPQITWFKNNHKIQQEPEL 707
+G+P P + W K+ + P +
Sbjct: 31819 SGIPPPTLKWEKDGQPLSLGPNI 31841
Score = 36.6 bits (83), Expect = 0.085
Identities = 34/118 (28%), Positives = 56/118 (47%), Gaps = 15/118 (12%)
Query: 295 VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRS-Y 353
+L I +D G Y CR+ S + V VH FI+ K Q LE + G+++ +
Sbjct: 12518 ILVIQNAHLEDAGNYNCRLPSSRTDGKVK--VHELAAEFIS----KPQNLEILEGEKAEF 12571
Query: 354 RLSMKVKAFPSPEVVWLKDGLPATEKSARY--LTRGYS--LIIKDVTEEDAGNYTILL 407
S+ ++FP V W +D E +Y + G L++KD T +D G Y +++
Sbjct: 12572 VCSISKESFP---VQWKRDD-KTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMV 12625
Score = 36.6 bits (83), Expect = 0.085
Identities = 28/84 (33%), Positives = 38/84 (45%), Gaps = 9/84 (10%)
Query: 352 SYRLSMKVKAFPSPEVVWLKDGLPA---TEKSARYLTRGYSLIIKDVTEEDAGNYTILLS 408
++RL + +K P+P V W K P T S +LI+ D + DAG YTI L
Sbjct: 19999 NFRLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITL- 20057
Query: 409 IKQSNVFKNLTATLIVNV--KPQI 430
NV T+ + V KP I
Sbjct: 20058 ---KNVAGTKEGTISIKVVGKPGI 20078
Score = 36.6 bits (83), Expect = 0.085
Identities = 21/81 (25%), Positives = 33/81 (40%), Gaps = 3/81 (3%)
Query: 346 TVAGKRSYRLSMKVKAFPSPEVVWLKDGLP---ATEKSARYLTRGYSLIIKDVTEEDAGN 402
TV ++ + P+P V W KD +P T +A L IKD ED G+
Sbjct: 22158 TVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDACREDVGH 22217
Query: 403 YTILLSIKQSNVFKNLTATLI 423
Y + L+ + L ++
Sbjct: 22218 YVVKLTNSAGEAIETLNVIVL 22238
Score = 36.6 bits (83), Expect = 0.085
Identities = 30/121 (24%), Positives = 41/121 (33%), Gaps = 8/121 (6%)
Query: 354 RLSMKVKAFPSPEVVWLKDG--LPATEKSARYLTRG----YSLIIKDVTEEDAGNYTILL 407
R + + P P V W K G + + +Y Y L I VT +D YT++
Sbjct: 31708 RFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVA 31767
Query: 408 SIK--QSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIK 465
K + + LT TL A G GIP PT+K
Sbjct: 31768 RNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLK 31827
Query: 466 W 466
W
Sbjct: 31828 W 31828
Score = 36.6 bits (83), Expect = 0.085
Identities = 35/123 (28%), Positives = 50/123 (40%), Gaps = 10/123 (8%)
Query: 320 KSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG-LPATE 378
KS + A I K R V E S R S P P V WL+ G + +T
Sbjct: 32549 KSTTRKIKTTLAARILTKPRSMTVYEG----ESARFSCDTDGEPVPTVTWLRKGQVLSTS 32604
Query: 379 KSARYLTRGY--SLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVS 436
+ T Y + I V D GNY++++ + T T+ K ++ EKAV+
Sbjct: 32605 ARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTI---QKARVTEKAVT 32661
Query: 437 SFP 439
S P
Sbjct: 32662 SPP 32664
Score = 36.2 bits (82), Expect = 0.11
Identities = 15/50 (30%), Positives = 23/50 (46%)
Query: 659 EAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPELY 708
EAP + + TV S G P+P+ W+KN KI++ +Y
Sbjct: 2076 EAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIY 2125
Score = 36.2 bits (82), Expect = 0.11
Identities = 91/419 (21%), Positives = 154/419 (36%), Gaps = 53/419 (12%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGK--RSY 353
LT+ + +D+G+YTC + V TS + +A H + E G +
Sbjct: 30590 LTVMTEEQEDEGVYTCIATN--EVGEVETSSKLLLQATPQF-HPGYPLKEKYYGAVGSTL 30646
Query: 354 RLSMKVKAFPSPEVVWLKDG--LPATEKSARYLTRGYS-LIIKDVTEED-AGNYTILLSI 409
RL + P P + W L +E T Y+ L++K+V + AG Y + LS
Sbjct: 30647 RLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLS- 30705
Query: 410 KQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTI----K 465
NVF + A L V ++ + PD P+ +L +A +P
Sbjct: 30706 ---NVFGTVDAILDVEIQDK---------PDKPTGPIVIEALLKNSAVISWKPPADDGGS 30753
Query: 466 WFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVA 525
W N+ +C+ E + A S RI ++T+ + +T ++
Sbjct: 30754 WIT-----NYVVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYF-RVSAQNTFGIS 30807
Query: 526 DSRISGIYICIAS--NKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKL-SCTVNKF 582
D + I S K G G+ IT V V K P K+ + + K
Sbjct: 30808 DPLEVSSVVIIKSPFEKPGAPGKPT---ITAVTKDSCVVAWKPPASDGGAKIRNYYLEKR 30864
Query: 583 LYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVY 642
+ WI + T R +S+ + E + +L ++
Sbjct: 30865 EKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCE------NLGGESEWS------E 30912
Query: 643 TGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKI 701
E I K ++ I +AP+ L + V S+ TL C G P+P + W++ +I
Sbjct: 30913 ISEPITPKSDVPI---QAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEI 30968
Score = 36.2 bits (82), Expect = 0.11
Identities = 34/160 (21%), Positives = 60/160 (37%), Gaps = 35/160 (21%)
Query: 569 EGEDLKLSCTVNKF-LYRDVTWIL-LRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNV 626
EG +K C + + VTW +R + N +K IT E + + L + ++
Sbjct: 31581 EGGHVKYVCKIENYDQSTQVTWYFGVRQLEN--------SEKYEITYEDGVAI-LYVKDI 31631
Query: 627 SLQDSGTYACRARNVY------------------------TGEEILQKKEITIRDQEAPY 662
+ D GTY C+ N Y T ++I ++ + + P
Sbjct: 31632 TKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPE 31691
Query: 663 LLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQ 702
L + T + + PEP +TW+K+ KI+
Sbjct: 31692 FTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIK 31731
Score = 35.4 bits (80), Expect = 0.19
Identities = 21/76 (27%), Positives = 37/76 (48%), Gaps = 3/76 (3%)
Query: 658 QEAPYL---LRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPELYTSTSPS 714
QEAP + ++ L+ TV + L G PEP+ITW K + ++Q+ + P
Sbjct: 13685 QEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPK 13744
Query: 715 SSSSSPLSSSSSSSSS 730
S+ + + S S + +
Sbjct: 13745 KSTVTIVDSKRSDTGT 13760
Score = 35.4 bits (80), Expect = 0.19
Identities = 30/106 (28%), Positives = 51/106 (48%), Gaps = 8/106 (7%)
Query: 352 SYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGY-SLIIKDVTEEDAGNYTILLSIK 410
S RL + +K P+PEV W K + + +T + SL++ +V D+G YT+ L
Sbjct: 22959 SLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTSLVLDNVNRYDSGKYTLTLENS 23018
Query: 411 QSNVFKNLTATLI------VNVK-PQIYEKAVSSFPDPALYPLGSR 449
+T ++ VN+K +I + +VS +P L GS+
Sbjct: 23019 SGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITWEPPLLDGGSK 23064
Score = 35.4 bits (80), Expect = 0.19
Identities = 20/72 (27%), Positives = 36/72 (50%), Gaps = 7/72 (9%)
Query: 354 RLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGY---SLIIKDVTEEDAGNYTILLSIK 410
++ + + P P + W KDGLP + + +T +L IK+ ++D G Y I +
Sbjct: 23248 KIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITV--- 23304
Query: 411 QSNVFKNLTATL 422
+NV TA++
Sbjct: 23305 -ANVVGQKTASI 23315
Score = 35.0 bits (79), Expect = 0.25
Identities = 24/76 (31%), Positives = 39/76 (51%), Gaps = 3/76 (3%)
Query: 354 RLSMKVKAFPSPEVVWLKDGLPATEKSARYLTR-GYSLIIKDVTEEDAGNYTILLSIKQS 412
RLS +K P P+V W K+ A K+ +T G L I++ ED G Y+ L+++
Sbjct: 17237 RLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSKLEIRNAAHEDGGIYS--LTVENP 17294
Query: 413 NVFKNLTATLIVNVKP 428
K ++ ++V KP
Sbjct: 17295 AGSKTVSVKVLVLDKP 17310
Score = 35.0 bits (79), Expect = 0.25
Identities = 24/70 (34%), Positives = 37/70 (52%), Gaps = 4/70 (5%)
Query: 339 RKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYS-LIIKDVTE 397
RK VL A + RL + +K P PEV W K T+++ +T ++ L+I +VT
Sbjct: 25114 RKVVVLRASA---TLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVTSSFTMLVIDNVTR 25170
Query: 398 EDAGNYTILL 407
D+G Y + L
Sbjct: 25171 FDSGRYNLTL 25180
Score = 35.0 bits (79), Expect = 0.25
Identities = 18/57 (31%), Positives = 28/57 (49%), Gaps = 3/57 (5%)
Query: 352 SYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLT---RGYSLIIKDVTEEDAGNYTI 405
S R+ V+ P P V W KDG+ ++ +T SL ++D T + G YT+
Sbjct: 27975 SLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYTV 28031
Score = 34.7 bits (78), Expect = 0.32
Identities = 36/124 (29%), Positives = 51/124 (41%), Gaps = 19/124 (15%)
Query: 331 KAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG--LPATEK-SARYLTRG 387
K + VK + +L+ AG+ ++RL V P P + W KDG L T K +
Sbjct: 21460 KIKVDVKFKDTVILK--AGE-AFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFS 21516
Query: 388 YSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLG 447
+L+ KD T D+G YT LTAT I+ V P P PL
Sbjct: 21517 TNLVNKDSTRRDSGAYT-------------LTATNPGGFAKHIFNVKVLDRPGPPEGPLA 21563
Query: 448 SRQI 451
++
Sbjct: 21564 VTEV 21567
Score = 34.7 bits (78), Expect = 0.32
Identities = 19/80 (23%), Positives = 35/80 (43%), Gaps = 3/80 (3%)
Query: 354 RLSMKVKAFPSPEVVWLKDGLP---ATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIK 410
++ + V P P + W+KDG P T + L IK+ ++D G YT+ +
Sbjct: 24330 KIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNS 24389
Query: 411 QSNVFKNLTATLIVNVKPQI 430
+NL+ ++ P +
Sbjct: 24390 AGTATENLSVIVLEKPGPPV 24409
Score = 34.7 bits (78), Expect = 0.32
Identities = 25/96 (26%), Positives = 43/96 (44%), Gaps = 16/96 (16%)
Query: 354 RLSMKVKAFPSPEVVWLKDGLPATEKSARYL--TRGYSLI-IKDVTEEDAGNYTILLSIK 410
+++ + P P + W KDG+ E++ + T ++L+ +KD D G Y + L
Sbjct: 25808 KINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQYVLTL--- 25864
Query: 411 QSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPL 446
KN+ T V V ++ +K P P PL
Sbjct: 25865 -----KNVAGTRSVAVNCKVLDK-----PGPPAGPL 25890
Score = 34.3 bits (77), Expect = 0.42
Identities = 17/55 (30%), Positives = 27/55 (49%), Gaps = 6/55 (10%)
Query: 659 EAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPELYTSTSP 713
+AP + L V S+ T + H +G P P+++WF++ I TST P
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVIS------TSTLP 52
Score = 34.3 bits (77), Expect = 0.42
Identities = 27/114 (23%), Positives = 51/114 (44%), Gaps = 6/114 (5%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLE-TVAGKRSYR 354
LTI + + G Y+ + +G ++ + KA + Q++ TV R
Sbjct: 65 LTIPAVTKANSGRYSLKATNGSG--QATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVR 122
Query: 355 LSMKVKAFPSPEVVWLKDGLPATEKSARYLTRG---YSLIIKDVTEEDAGNYTI 405
L ++V P+P V + +DG +++ YSL+I + ED+G Y++
Sbjct: 123 LQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSV 176
Score = 34.3 bits (77), Expect = 0.42
Identities = 49/206 (23%), Positives = 83/206 (40%), Gaps = 25/206 (12%)
Query: 240 VKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTID 299
V L G T + C + P V+ W K + + H LTI
Sbjct: 8754 VTLKEGQTCTMTCQFSVP---NVKSEWFRNGRILKPQGRHKTEVEHKVHK------LTIA 8804
Query: 300 KMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAF-ITVKHRKQQVLETVAGKRSYRLSMK 358
++ +D+G YTC+ ++ + TS + +A I R Q ++ V+ +S +
Sbjct: 8805 DVRAEDQGQYTCK------YEDLETSAELRIEAEPIQFTKRIQNIV--VSEHQSATFECE 8856
Query: 359 VKAFPSPEVVWLKDGLPATEKSARYLTRG----YSLIIKDVTEEDAGNYTILLSIKQSNV 414
V +F V W K TE S +Y R + + I +VT +D G Y+++ ++
Sbjct: 8857 V-SFDDAIVTWYKGPTELTE-SQKYNFRNDGRCHYMTIHNVTPDDEGVYSVIARLEPRGE 8914
Query: 415 FKNLTATLIVNVKPQIYEKAVSSFPD 440
++ TA L + K E PD
Sbjct: 8915 ARS-TAELYLTTKEIKLELKPPDIPD 8939
Score = 33.9 bits (76), Expect = 0.55
Identities = 65/300 (21%), Positives = 110/300 (36%), Gaps = 37/300 (12%)
Query: 142 IPEIIHMTEGRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFI-ISNATY 199
+ E + TEG + RV S ITV K ++ I + + + + A
Sbjct: 8255 LSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGM 8314
Query: 200 KEIGLLTCEATVN-GHLYKTNYLTHRQTNT--IIDVQISTPRPVKLLRGHTLVLNCTATT 256
+ GL TC+ + + G T+ + ++ + D ++ PV + G + L+C
Sbjct: 8315 NDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLT---PVTVSEGEYVQLSCHVQG 8371
Query: 257 PLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYS---VLTIDKMQNKDKGLYTCRV 313
R+Q W R I S+ + F S VL + + D G Y C+
Sbjct: 8372 SEPIRIQ--W---------LKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKA 8420
Query: 314 RSGPSFKSVNTSVHIYDKAFITVKHRKQQV---LETVAGKRSYRLSMKVKAF-------- 362
+ + + V I DK + +K V L V+ +S R+ K A
Sbjct: 8421 SNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGD 8480
Query: 363 PSPEVVWLKDGLPATEKSARYLTR----GYSLIIKDVTEEDAGNYTILLSIKQSNVFKNL 418
P P V W K + R L I+D T+ D+G Y + + + N+
Sbjct: 8481 PIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNV 8540
Score = 33.5 bits (75), Expect = 0.72
Identities = 30/106 (28%), Positives = 51/106 (48%), Gaps = 8/106 (7%)
Query: 352 SYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYS-LIIKDVTEEDAGNY--TILLS 408
S R+ + +K P+PEV W KD + ++ T ++ LII + D G + TI
Sbjct: 20793 SIRIFVPIKGRPAPEVTWTKDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENP 20852
Query: 409 IKQSNVFKNL----TATLIVNVKP-QIYEKAVSSFPDPALYPLGSR 449
+ + F N+ T ++N++P I + +V+ D L GSR
Sbjct: 20853 AGKKSGFVNVRVLDTPGPVLNLRPTDITKDSVTLHWDLPLIDGGSR 20898
Score = 33.1 bits (74), Expect = 0.94
Identities = 54/238 (22%), Positives = 87/238 (36%), Gaps = 27/238 (11%)
Query: 207 CEAT--VNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQM 264
C+ T + G YK + + V+I V L T T T + + +
Sbjct: 15254 CDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGPPTSPERLTYTERTKSTITL 15313
Query: 265 TWSYPDEKNKRASVRRRIDQSNSH-------ANIFYSVLTIDKMQNKDKG-LYTCRVRS- 315
W P N + ++ I + H N T ++N D+ +Y RV++
Sbjct: 15314 DWKEP-RSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMYEFRVKAV 15372
Query: 316 ---GPSFKSVNTSVHIYDKAFI-TVKHRKQQVLETVAGKRS--YRLSMKVKAFPSPEVVW 369
G S S+ +V I D T+K R +T+ K + V P P++ W
Sbjct: 15373 NEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEW 15432
Query: 370 LK---------DGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNL 418
K D L T++ L I ED G YT+ S + +VF+N+
Sbjct: 15433 SKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFRNV 15490
Score = 32.7 bits (73), Expect = 1.2
Identities = 81/394 (20%), Positives = 143/394 (36%), Gaps = 70/394 (17%)
Query: 346 TVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRG---YSLIIKDVTEEDAGN 402
TV ++ R+ +VK P P++ W K+G + L + L IK+ D G
Sbjct: 17919 TVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGK 17978
Query: 403 YTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQP 462
Y ++S K S+ + + IVNV + P P Q L T
Sbjct: 17979 Y--IISAKNSS--GHAQGSAIVNVLDR---------PGPC-------QNLKVTNVTKENC 18018
Query: 463 TIKWFWHPCNHNHSEAR---CDFCSNNEESFILDADSNMGNRIESITQRM--AIIEGKNK 517
TI W +P ++ SE ++ N++ + + A +T+R+ A + N+
Sbjct: 18019 TISW-ENPLDNGGSEITNFIVEYRKPNQKGWSIVA--------SDVTKRLIKANLLANNE 18069
Query: 518 -----MASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGF-HVNLEKMPTEGE 571
A V I +A N + G + +I D F ++ + +G
Sbjct: 18070 YYFRVCAENKVGVGPTIETKTPILAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGG 18129
Query: 572 DLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDS 631
LS V + L W + + + HY + + ++
Sbjct: 18130 SPNLSYHVERRLKGSDDWERVHKGSIKETHYMVDR---------------------CVEN 18168
Query: 632 GTYACRARNVYTGEEI--LQKKEITIR-DQEAPYLLRNLSD-HTVAISSSTTLDCHANGV 687
Y R + G E ++ +E+ ++ D + P L LS TV + L+ G
Sbjct: 18169 QIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRGK 18228
Query: 688 PEPQITWFKNNH--KIQQEPELYTSTSPSSSSSS 719
P P++ W K+ + + P + T SS S
Sbjct: 18229 PFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFS 18262
Score = 32.7 bits (73), Expect = 1.2
Identities = 24/88 (27%), Positives = 41/88 (46%), Gaps = 11/88 (12%)
Query: 347 VAGKRSYRLSMKVKAFPSPEVVWLKDGLPATE------KSARYLTRGYSLIIKDVTEEDA 400
V + ++ + K P V W KDG E S++ +T SL IK+ ++ED
Sbjct: 25406 VKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVT---SLSIKEASKEDV 25462
Query: 401 GNYTILLSIKQSNVFKNLTATLIVNVKP 428
G Y + +S ++ + T+IV +P
Sbjct: 25463 GTYELCVSNSAGSI--TVPITIIVLDRP 25488
Score = 32.7 bits (73), Expect = 1.2
Identities = 20/65 (30%), Positives = 30/65 (46%), Gaps = 8/65 (12%)
Query: 266 WSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTS 325
WS PD S+R I ++S +S LT++ D G YT V + KS+ +
Sbjct: 28391 WSKPDSN---LSLRADIHTTDS-----FSTLTVENCNRNDAGKYTLTVENNSGSKSITFT 28442
Query: 326 VHIYD 330
V + D
Sbjct: 28443 VKVLD 28447
Score = 32.3 bits (72), Expect = 1.6
Identities = 23/88 (26%), Positives = 38/88 (43%), Gaps = 12/88 (13%)
Query: 363 PSPEVVWLKDGLPAT-----EKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKN 417
P P V W K G+P T + S T L+I +DAG YTI++ K +
Sbjct: 1109 PKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSAS 1168
Query: 418 LT-------ATLIVNVKPQIYEKAVSSF 438
+ L+ + + +Y+ V++F
Sbjct: 1169 ASLLEEADYELLMKSQQEMLYQTQVTAF 1196
Score = 32.3 bits (72), Expect = 1.6
Identities = 16/68 (23%), Positives = 33/68 (48%), Gaps = 3/68 (4%)
Query: 646 EILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEP 705
E+L ++ T+ AP + + H V +T + P ++ W+ N ++Q+
Sbjct: 32361 EVLSQQPFTL--DHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESS 32418
Query: 706 EL-YTSTS 712
++ YT+TS
Sbjct: 32419 KIHYTNTS 32426
Score = 32.0 bits (71), Expect = 2.1
Identities = 16/58 (27%), Positives = 32/58 (55%), Gaps = 1/58 (1%)
Query: 354 RLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYS-LIIKDVTEEDAGNYTILLSIK 410
RL++ +K P P W K+G ++++ + ++ L+IK+ D+G Y ++L K
Sbjct: 30155 RLTIPIKGKPFPICKWTKEGQDISKRAMIATSETHTELVIKEADRGDSGTYDLVLENK 30212
Score = 31.6 bits (70), Expect = 2.7
Identities = 34/127 (26%), Positives = 60/127 (47%), Gaps = 17/127 (13%)
Query: 292 FYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKR 351
F S+LTID +D Y+C + + K+ T+ I + A + L+ +
Sbjct: 2230 FLSILTIDTSDAED---YSCVLVEDENVKT--TAKLIVEGAVVEFVKE----LQDIEVPE 2280
Query: 352 SYRLSMKVKAFPSPEVV---WLKDGLPATEKSARYLT--RG-YSLIIKDVTEEDAGNYTI 405
SY S +++ SPE + W + + +T RG +L +KDVT+ED G Y+
Sbjct: 2281 SY--SGELECIVSPENIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEYSF 2338
Query: 406 LLSIKQS 412
++ K++
Sbjct: 2339 VIDGKKT 2345
Score = 31.6 bits (70), Expect = 2.7
Identities = 21/67 (31%), Positives = 31/67 (46%), Gaps = 8/67 (11%)
Query: 264 MTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVN 323
+TWS ++ + R ID + S YS+L +DK+ D G YT + KS
Sbjct: 29478 ITWS---KQGIDLASRAIIDTTES-----YSLLIVDKVNRYDAGKYTIEAENQSGKKSAT 29529
Query: 324 TSVHIYD 330
V +YD
Sbjct: 29530 VLVKVYD 29536
Score = 31.2 bits (69), Expect = 3.6
Identities = 21/82 (25%), Positives = 33/82 (40%), Gaps = 1/82 (1%)
Query: 618 TLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEI-TIRDQEAPYLLRNLSDHTVAISS 676
T +L I+ + DSG + A+N I + + Q P + L + + S
Sbjct: 1512 TQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGS 1571
Query: 677 STTLDCHANGVPEPQITWFKNN 698
+ A G P P I W KN+
Sbjct: 1572 RLEMKVRATGNPNPDIVWLKNS 1593
Score = 31.2 bits (69), Expect = 3.6
Identities = 26/72 (36%), Positives = 38/72 (52%), Gaps = 7/72 (9%)
Query: 305 DKGLYT--CRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAF 362
D G +T + R+G S SV +V + VK + L+ V K RL MKV+A
Sbjct: 1524 DSGEWTVVAQNRAGRSSISVILTVEAVEHQ---VKPMFVEKLKNVNIKEGSRLEMKVRAT 1580
Query: 363 --PSPEVVWLKD 372
P+P++VWLK+
Sbjct: 1581 GNPNPDIVWLKN 1592
Score = 31.2 bits (69), Expect = 3.6
Identities = 20/83 (24%), Positives = 37/83 (44%), Gaps = 9/83 (10%)
Query: 614 EHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVA 673
EH + LTI +V +D G Y C+ ++ T E+ + E + + + V+
Sbjct: 8795 EHKVH-KLTIADVRAEDQGQYTCKYEDLETSAELR-------IEAEPIQFTKRIQNIVVS 8846
Query: 674 ISSSTTLDCHANGVPEPQITWFK 696
S T +C + + +TW+K
Sbjct: 8847 EHQSATFECEVS-FDDAIVTWYK 8868
Score = 31.2 bits (69), Expect = 3.6
Identities = 22/82 (26%), Positives = 37/82 (45%), Gaps = 10/82 (12%)
Query: 621 LTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPY-LLRNLSDHTVAISSSTT 679
LT+ +V L+D+G A++ T + K E P + L D TV ++
Sbjct: 12252 LTLRDVKLEDAGEVQLTAKDFKTHANLFVK--------EPPVEFTKPLEDQTVEEGATAV 12303
Query: 680 LDCHANGVPEPQITWFKNNHKI 701
L+C + ++ WFKN +I
Sbjct: 12304 LECEVSR-ENAKVKWFKNGTEI 12324
Score = 31.2 bits (69), Expect = 3.6
Identities = 24/83 (28%), Positives = 38/83 (45%), Gaps = 19/83 (22%)
Query: 352 SYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGY--------SLIIKDVTEEDAGNY 403
S+ +++ + P P V+W K P T+ TR Y SL I++ D+G Y
Sbjct: 26203 SFTMTVPFRGRPVPNVLWSK---PDTDLR----TRAYVDTTDSRTSLTIENANRNDSGKY 26255
Query: 404 TILLSIKQSNVFKNLTATLIVNV 426
T+ + NV + TL+V V
Sbjct: 26256 TLTI----QNVLSAASLTLVVKV 26274
Score = 31.2 bits (69), Expect = 3.6
Identities = 13/45 (28%), Positives = 22/45 (48%)
Query: 659 EAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQ 703
EAP + + + D T + + L C G P P I W++ ++ Q
Sbjct: 30531 EAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ 30575
Score = 30.8 bits (68), Expect = 4.7
Identities = 18/59 (30%), Positives = 28/59 (47%), Gaps = 4/59 (6%)
Query: 351 RSYRLSMKVKAFPSPEVVWLKDGLP-ATEKSARYLTRG---YSLIIKDVTEEDAGNYTI 405
+S ++V P P + W KDG P + + + G Y+L I+D ED G Y +
Sbjct: 31810 QSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRV 31868
Score = 30.8 bits (68), Expect = 4.7
Identities = 24/73 (32%), Positives = 33/73 (45%), Gaps = 6/73 (8%)
Query: 342 QVLETVAGKRSYRLSMKVKA--FPSPEVVWLKDGLPATEKSA---RYLTRG-YSLIIKDV 395
Q L+ A K +L+ V++ + EV W KDG E Y G Y L I ++
Sbjct: 32722 QFLKAEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNL 32781
Query: 396 TEEDAGNYTILLS 408
TE D G Y +S
Sbjct: 32782 TESDQGEYVCEIS 32794
Score = 30.4 bits (67), Expect = 6.1
Identities = 39/201 (19%), Positives = 77/201 (38%), Gaps = 24/201 (11%)
Query: 234 ISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFY 293
I P+ V L T+ + + + V + W + + K + R + + H
Sbjct: 2798 IKKPKDVTALENATVAFEVSVS---HDTVPVKWFHKSVEIKPSDKHRLVSERKVHK---- 2850
Query: 294 SVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLET-VAGKRS 352
L + + D G YT +V + K F+ H + + V ++
Sbjct: 2851 --LMLQNISPSDAGEYT----------AVVGQLECKAKLFVETLHITKTMKNIEVPETKT 2898
Query: 353 YRLSMKVKAFPSPEVVWLKDGLPAT-EKSARYLTRG--YSLIIKDVTEEDAGNYTILLSI 409
+V F P + WLK+G+ + + + +G + LII + + ED+ YT +
Sbjct: 2899 ASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGN 2957
Query: 410 KQSNVFKNLTATLIVNVKPQI 430
Q + +T +I ++ I
Sbjct: 2958 DQVSATLTVTPIMITSMLKDI 2978
Score = 30.4 bits (67), Expect = 6.1
Identities = 31/143 (21%), Positives = 54/143 (37%), Gaps = 8/143 (5%)
Query: 598 RTMHYSISKQKMAITKEHSITLN-----LTIMNVSLQD-SGTYACRARNVYTGEEILQKK 651
RT Y++S K E S ++ +T SL + + ++ E+ L++K
Sbjct: 32490 RTEAYAVSSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEK 32549
Query: 652 EIT--IRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPELYT 709
T I+ A +L TV S C +G P P +TW + +
Sbjct: 32550 STTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQV 32609
Query: 710 STSPSSSSSSPLSSSSSSSSSSS 732
+T+ S+ S +S + S
Sbjct: 32610 TTTKYKSTFEISSVQASDEGNYS 32632
Score = 30.0 bits (66), Expect = 8.0
Identities = 23/90 (25%), Positives = 36/90 (40%), Gaps = 8/90 (8%)
Query: 613 KEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTV 672
KE +L + N L +G +A NV + + K + LLR L D TV
Sbjct: 12155 KEEGKIHSLVLHNCRLDQTGGVDFQAANVKSSAHLRVKPRVI-------GLLRPLKDVTV 12207
Query: 673 AISSSTTLDCHANGVPEPQITWFKNNHKIQ 702
+ T DC + P + W+ K++
Sbjct: 12208 TAGETATFDCELSYEDIP-VEWYLKGKKLE 12236
Score = 30.0 bits (66), Expect = 8.0
Identities = 24/107 (22%), Positives = 44/107 (41%), Gaps = 5/107 (4%)
Query: 614 EHSITLNLTIMNVSLQDSGTYACR--ARNVYTGEEILQKKE--ITIRDQEAPYLLRNLSD 669
E+S+ +L+++ L++ Y R ARN G + ++ E ++Q P +
Sbjct: 18849 EYSVVKDLSLVVTGLKEGKKYKFRVAARNA-VGVSLPREAEGVYEAKEQLLPPKILMPEQ 18907
Query: 670 HTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPELYTSTSPSSS 716
T+ ++ H G P P W K ++ L + SSS
Sbjct: 18908 ITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSS 18954
Score = 30.0 bits (66), Expect = 8.0
Identities = 29/109 (26%), Positives = 42/109 (38%), Gaps = 17/109 (15%)
Query: 341 QQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEK---SARYLTRGYSLIIKDVTE 397
Q+ + AG R L + + P P W G E + T+ L I++ T
Sbjct: 29745 QKTIHVPAG-RPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTI 29803
Query: 398 EDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPL 446
D G YT+ L KN+T T +K I +K P P P+
Sbjct: 29804 RDTGEYTLEL--------KNVTGTTSETIKVIILDK-----PGPPTGPI 29839
Score = 30.0 bits (66), Expect = 8.0
Identities = 21/70 (30%), Positives = 37/70 (52%), Gaps = 9/70 (12%)
Query: 363 PSPEVVWLKDGLPA-TEKSARYLTRGY----SLIIKDVTEEDAGNYTILLSIKQSNVFKN 417
P+PEV W G +++ R+ +LII DV ++D G YT+ L N F +
Sbjct: 33356 PTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSL----GNEFGS 33411
Query: 418 LTATLIVNVK 427
+AT+ ++++
Sbjct: 33412 DSATVNIHIR 33421
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 81.3 bits (199), Expect = 3e-15
Identities = 115/453 (25%), Positives = 164/453 (36%), Gaps = 83/453 (18%)
Query: 248 LVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKG 307
L+++C+ + L R+Q+ R R +S N + +L K + +G
Sbjct: 327 LLVSCSVHSALPFRLQLR-----RGEARLGEERHFQESG---NSSWEILRASKAE---EG 375
Query: 308 LYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLE----TVAGKRSYRLSMKVKAFP 363
Y C S KA I V Q++ TV+ + LS +V
Sbjct: 376 TYECTAVSRAGTGRA--------KAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEA 427
Query: 364 SPEVVWLKDG--LPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTAT 421
+ W++D LPA+ L SL I + D G Y + S +N +
Sbjct: 428 PYNLTWVRDWRVLPASTGRVAQLA-DLSLEISGIIPTDGGRYQCVAS--NANGVTRASVW 484
Query: 422 LIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCD 481
L+V PQ VS + G ++C+A G P P I W
Sbjct: 485 LLVREAPQ-----VSIHTSSQHFSQGVEVKVSCSASGYPTPHISW--------------- 524
Query: 482 FCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKV 541
+ ES L DS RI Q II+G +G Y C A+N+V
Sbjct: 525 ----SRESQALQEDS----RIHVDAQGTLIIQG----------VAPEDAGNYSCQATNEV 566
Query: 542 GTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMH 601
GT ++ Y TD P+ VN + GE+ L C + V W
Sbjct: 567 GTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR---------- 616
Query: 602 YSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAP 661
+M + E S + L I +D+GTY CRA N E EI + AP
Sbjct: 617 ---GGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVN----ELGDASAEIQLAVGHAP 669
Query: 662 YLLRNLSDHTVAISSSTTLDCHANGVPEPQITW 694
L D TV + S L C A G P P +TW
Sbjct: 670 QLTELPRDVTVELGRSALLACRATGRPPPTVTW 702
Score = 72.8 bits (177), Expect = 1e-12
Identities = 134/621 (21%), Positives = 216/621 (34%), Gaps = 117/621 (18%)
Query: 108 KYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVT---SPN 164
+Y V ++ T +++++ + + + + S+ H ++G E+ + C + +P+
Sbjct: 467 RYQCVASNANGVTRASVWLLVREAPQVSIHTSSQ-----HFSQGVEVKVSCSASGYPTPH 521
Query: 165 ITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHR 224
I+ + + L + RI D++ II ++ G +C+AT T +
Sbjct: 522 ISWSRESQALQ----EDSRIHVDAQGTLIIQGVAPEDAGNYSCQAT-------NEVGTDQ 570
Query: 225 QTNTIIDVQ---ISTPRPVKLLR-GHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRR 280
+T T+ +S V L+ G VL C A+ RV W R +
Sbjct: 571 ETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRV--IWY-------RGGLEM 621
Query: 281 RIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRK 340
+ S + L I Q +D G YTCR + S + + +T R
Sbjct: 622 ILAPEGSSSG----KLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRD 677
Query: 341 QQVLETVAGKRSYRLSMKVKAFPSPEVVWLK-DGLP------ATEKSARYLTRGYSLIIK 393
TV RS L+ + P P V W + DG P A S L +
Sbjct: 678 V----TVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFE 733
Query: 394 DVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILT 453
V ED Y + NVF + A + V + SS P + G L
Sbjct: 734 SVAPEDQAPYVC----EARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLE-GQPVSLP 788
Query: 454 CTAY-GIPQPTIKWFWH----PCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQR 508
C G P P W P HS + AD ++ ++ Q
Sbjct: 789 CIVLAGRPLPERHWLKDGRPLPPGSRHS---------------IRADGSL--HLDRALQE 831
Query: 509 MAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPT 568
A G Y C+A+N G+ R++ + P +
Sbjct: 832 HA--------------------GRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITN 871
Query: 569 EGEDLKLSCTVNKFLYRDVTWIL-LRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVS 627
EG L C + +TW + +R HY++SK+ L I S
Sbjct: 872 EGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEG-----------TLLIAQPS 920
Query: 628 LQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDH-------TVAISSSTTL 680
QD+G Y C A N +E+ + P + N S + T TL
Sbjct: 921 AQDAGAYVCTATNTVG----FSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTL 976
Query: 681 DCHANGVPEPQITWFKNNHKI 701
DC A G P P +TW K++ +
Sbjct: 977 DCEAKGSPPPLVTWTKDSRPV 997
Score = 67.4 bits (163), Expect = 5e-11
Identities = 128/632 (20%), Positives = 220/632 (34%), Gaps = 114/632 (18%)
Query: 32 PELSLKGTQHIMQAGQTLHLQCRGEAAH----KWSLPEMVSKESERLSITKSACGRNGKQ 87
P++S+ + G + + C WS +E R+ +
Sbjct: 491 PQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG------- 543
Query: 88 FCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIH 147
TL + G YSC+ T++ + + ++ +D P V S + ++
Sbjct: 544 ---TLIIQGVAPEDAGNYSCQ----ATNEVGTDQETVTLYYTDP--PSV---SAVNAVVL 591
Query: 148 MTEGRELVIPCRVTS-PNITVTLKKFPLDTLI-PDGKRIIWDSRKGFIISNATYKEIGLL 205
+ G E V+ C + P V + L+ ++ P+G S I A ++ G
Sbjct: 592 VAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS-----SSGKLRIPAAQERDAGTY 646
Query: 206 TCEATVN-GHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTAT-TPLNTRVQ 263
TC A G L + ++ PR V + G + +L C AT P T
Sbjct: 647 TCRAVNELGDASAEIQLAVGHAPQLTEL----PRDVTVELGRSALLACRATGRPPPT--- 699
Query: 264 MTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVN 323
+TW D + +R + + VL + + +D+ Y C R+ F V
Sbjct: 700 VTWRRGD--GQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARN--VFGKVQ 755
Query: 324 TSVHIYDKAFITVKHRKQQV------LETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPAT 377
+ I H Q+ + + G+ + + P PE WLKDG P
Sbjct: 756 AEARL-----IVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLP 810
Query: 378 EKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSS 437
S + SL + +E AG Y+ + + + +++ L+V V P+I+ A
Sbjct: 811 PGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDV--ELVVQVPPRIHPTATHH 868
Query: 438 FPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSN 497
+ G L C A G+P PTI W
Sbjct: 869 ITNE-----GVPASLPCVASGVPAPTITW------------------------------- 892
Query: 498 MGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVP- 556
++T R + + ++ +G Y+C A+N VG + + + P
Sbjct: 893 -TKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPR 951
Query: 557 ---NG---FHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMA 610
NG +V L+ GE++ L C VTW S+
Sbjct: 952 IHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWT------------KDSRPVPP 999
Query: 611 ITKEHSI--TLNLTIMNVSLQDSGTYACRARN 640
IT + + + +L + V + DSG Y C A N
Sbjct: 1000 ITNRYGLLPSGSLRLAQVQVGDSGHYECTASN 1031
Score = 62.4 bits (150), Expect = 1e-09
Identities = 48/206 (23%), Positives = 95/206 (46%), Gaps = 28/206 (13%)
Query: 506 TQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPN-GFHVNLE 564
T R+A + + S ++ D G Y C+ASN G ++ + + P H + +
Sbjct: 444 TGRVAQLADLSLEISGIIPTDG---GRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQ 500
Query: 565 KMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLN---- 620
++G ++K+SC+ + + T H S S++ A+ ++ I ++
Sbjct: 501 HF-SQGVEVKVSCSASGY---------------PTPHISWSRESQALQEDSRIHVDAQGT 544
Query: 621 LTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTL 680
L I V+ +D+G Y+C+A N E ++ +T+ + P + + VA+ L
Sbjct: 545 LIIQGVAPEDAGNYSCQATN----EVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVL 600
Query: 681 DCHANGVPEPQITWFKNNHKIQQEPE 706
C A+GVP P++ W++ ++ PE
Sbjct: 601 VCEASGVPPPRVIWYRGGLEMILAPE 626
Score = 48.5 bits (114), Expect = 2e-05
Identities = 40/178 (22%), Positives = 70/178 (39%), Gaps = 14/178 (7%)
Query: 531 GIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWI 590
G Y C A ++ GT +TD P + GE LSC V ++TW+
Sbjct: 375 GTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWV 434
Query: 591 LLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQK 650
+ R + S + L+L I + D G Y C A N + +
Sbjct: 435 R----DWRVLPASTGRVAQLAD------LSLEISGIIPTDGGRYQCVASNANG----VTR 480
Query: 651 KEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPELY 708
+ + +EAP + + S + + C A+G P P I+W + + +Q++ ++
Sbjct: 481 ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIH 538
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 80.5 bits (197), Expect = 5e-15
Identities = 109/482 (22%), Positives = 178/482 (36%), Gaps = 76/482 (15%)
Query: 234 ISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSH----- 288
+ P + + +G LNC A ++ W E+ V D SH
Sbjct: 32 VEHPSDLIVSKGEPATLNCKAEGRPTPTIE--WYKGGER-----VETDKDDPRSHRMLLP 84
Query: 289 -ANIFYSVLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLE 345
++F+ + + D+G+Y C R+ G + S N S+ + A + R+
Sbjct: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEV---AILRDDFRQNPSDV 140
Query: 346 TVA-GKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNY- 403
VA G+ + + P P + W KDG P +K R RG L+I + DAG Y
Sbjct: 141 MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYV 200
Query: 404 ---TILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIP 460
T ++ ++S V A L V +P ++ P + C A G P
Sbjct: 201 CVGTNMVGERESEV-----AELTVLERPSFVKR-----PSNLAVTVDDSAEFKCEARGDP 250
Query: 461 QPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMAS 520
PT++W R D + + + D + +I +T
Sbjct: 251 VPTVRW------------RKDDGELPKSRYEIRDDHTL--KIRKVT-------------- 282
Query: 521 TLVVADSRISGIYICIASNKVGTV--GRNISFYITDVPNGFHVN-LEKMPTEGEDLKLSC 577
+ G Y C+A N VG ++ + P F V +++ G + C
Sbjct: 283 ------AGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQC 336
Query: 578 TVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACR 637
+ W R ++ + +S + + S T +LTI NV D G Y C+
Sbjct: 337 EATGNPQPAIFW---RREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQ 393
Query: 638 ARNVYTGEEILQKKEIT--IRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWF 695
NV E+T I D+ P + + + TVA+ + L C A G P P I W
Sbjct: 394 TLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWR 453
Query: 696 KN 697
K+
Sbjct: 454 KD 455
Score = 53.9 bits (128), Expect = 5e-07
Identities = 78/384 (20%), Positives = 135/384 (35%), Gaps = 71/384 (18%)
Query: 355 LSMKVKAFPSPEVVWLKDGLPA-TEK----SARYLTRGYSLIIKDV-----TEEDAGNYT 404
L+ K + P+P + W K G T+K S R L SL + + D G Y
Sbjct: 48 LNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYV 107
Query: 405 ILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTA-YGIPQPT 463
+ + + + ++ + P + +G ++ C G P+PT
Sbjct: 108 CVARNYLGEAVSHNASLEVAILRDDFRQN-----PSDVMVAVGEPAVMECQPPRGHPEPT 162
Query: 464 IKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLV 523
I W G+ ++ +R+ I GK L+
Sbjct: 163 ISW-----------------------------KKDGSPLDDKDERITIRGGK------LM 187
Query: 524 VADSRIS--GIYICIASNKVGTVGRNIS-FYITDVPNGFHVNLEKMPTEGEDLKLSCTVN 580
+ +R S G Y+C+ +N VG ++ + + P+ T + + C
Sbjct: 188 ITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEAR 247
Query: 581 KFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
V W R + K + I +H+ L I V+ D G+Y C A N
Sbjct: 248 GDPVPTVRW--------RKDDGELPKSRYEIRDDHT----LKIRKVTAGDMGSYTCVAEN 295
Query: 641 VYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHK 700
+ E + + E P+ + D VA+ + T C A G P+P I W +
Sbjct: 296 MVGKAEASATLTVQV-GSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREG-- 352
Query: 701 IQQEPELYTSTSPSSSSSSPLSSS 724
+ L++ P SSS +S +
Sbjct: 353 --SQNLLFSYQPPQSSSRFSVSQT 374
Score = 49.3 bits (116), Expect = 1e-05
Identities = 79/321 (24%), Positives = 125/321 (38%), Gaps = 46/321 (14%)
Query: 108 KYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITV 167
KY+ V T+ E ES + FV+ S + + + + E R P TV
Sbjct: 198 KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLA--VTVDDSAEFKCEAR-GDPVPTV 254
Query: 168 TLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTN 227
+K D +P + I D I T ++G TC A N + + +
Sbjct: 255 RWRKD--DGELPKSRYEIRDDHT-LKIRKVTAGDMGSYTCVAE--------NMVGKAEAS 303
Query: 228 TIIDVQIST--------PRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVR 279
+ VQ+ + PR + G T+ C AT N + + W +N S +
Sbjct: 304 ATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATG--NPQPAIFWRREGSQNLLFSYQ 361
Query: 280 RRIDQSNSHANIFYSV-LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKH 338
QS+S ++ + LTI +Q D G Y C+ ++N + I KA++ V
Sbjct: 362 P--PQSSSRFSVSQTGDLTITNVQRSDVGYYICQ--------TLNVAGSIITKAYLEVTD 411
Query: 339 ----------RKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG-LPATEKSARYLTRG 387
R+ V +TVA ++ LS P P ++W KDG L +T+ S
Sbjct: 412 VIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLEN 471
Query: 388 YSLIIKDVTEEDAGNYTILLS 408
L I+ D G YT + S
Sbjct: 472 GVLQIRYAKLGDTGRYTCIAS 492
Score = 40.8 bits (94), Expect = 0.005
Identities = 101/477 (21%), Positives = 164/477 (34%), Gaps = 77/477 (16%)
Query: 25 SGSKLKDPELSLKGTQH----IMQAGQTLHLQCRGEAAHKWSLPEMVSKESERLSITKSA 80
SGS+L+ + + +H I+ G+ L C+ E ++ K ER+ K
Sbjct: 18 SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWY--KGGERVETDKDD 75
Query: 81 CGRN------GKQFCSTLTLNTAQANHTGFYSC---KYLAVPTSKKKETESAIYIFISDT 131
+ G F + G Y C YL S E AI
Sbjct: 76 PRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI------- 128
Query: 132 GRPFVEMYSEIPEIIHMTEGRELVIPCRVTS--PNITVTLKK--FPLDT-----LIPDGK 182
+ + + P + + G V+ C+ P T++ KK PLD I GK
Sbjct: 129 ---LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK 185
Query: 183 RIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKL 242
+I +RK + G C T N + R++ + P VK
Sbjct: 186 LMITYTRKS---------DAGKYVCVGT--------NMVGERESEVAELTVLERPSFVKR 228
Query: 243 LRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQ 302
+ ++ +A R + K+ + R + + H L I K+
Sbjct: 229 PSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHT------LKIRKVT 282
Query: 303 NKDKGLYTCRVRS--GPSFKSVNTSVHI-YDKAFITVKHRKQQVLETVAGKRSYRLSMKV 359
D G YTC + G + S +V + + VK R Q VA R+ +
Sbjct: 283 AGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQ----VVALGRTVTFQCEA 338
Query: 360 KAFPSPEVVWLKDGL--------PATEKSARYLTRGYSLIIKDVTEEDAGNYTI-LLSIK 410
P P + W ++G P S +++ L I +V D G Y L++
Sbjct: 339 TGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVA 398
Query: 411 QSNVFKN-LTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKW 466
S + K L T ++ +P + P + +L+C A G P PTI W
Sbjct: 399 GSIITKAYLEVTDVIADRPP---PVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW 452
Score = 37.0 bits (84), Expect = 0.065
Identities = 18/59 (30%), Positives = 29/59 (49%), Gaps = 3/59 (5%)
Query: 661 PYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQ---QEPELYTSTSPSSS 716
P ++ + SD V+ TL+C A G P P I W+K +++ +P + PS S
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 79.3 bits (194), Expect = 1e-14
Identities = 109/471 (23%), Positives = 182/471 (38%), Gaps = 74/471 (15%)
Query: 241 KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
K +RG+ V C + + + + D + + R I + + L I
Sbjct: 134 KTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGA--------LYIKD 185
Query: 301 MQNKDKGLYTCRV-----RSGPSFKSVNTSVHIYDKAFITVK------HRKQQVLETVAG 349
+QN+D GLY R +G + +S + + + D A HRK +AG
Sbjct: 186 VQNED-GLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRK-----AMAG 239
Query: 350 KRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSI 409
+R L K P P+ WLKD +P E S R+ L+I+++ D+G+Y +S
Sbjct: 240 QR-VELPCKALGHPEPDYRWLKDNMPL-ELSGRFQKTVTGLLIENIRPSDSGSYVCEVSN 297
Query: 410 KQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWH 469
+ TA +I + + KA S P +GS+ L+C+ G + W+
Sbjct: 298 RYG------TAKVIGRLYVKQPLKATIS-PRKVKSSVGSQVSLSCSVTGTEDQELSWY-- 348
Query: 470 PCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRI 529
N E IL+ N+ R+ I +N + +V +D
Sbjct: 349 --------------RNGE---ILNPGKNV---------RITGINHENLIMDHMVKSDG-- 380
Query: 530 SGIYICIASNKVGTVGRNISFYITD-VPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVT 588
G Y C + + + D P EK+ + E + L C V +T
Sbjct: 381 -GAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTIT 439
Query: 589 WILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEIL 648
W L + + IS+ IT E ++ L I + ++D G Y C A N + +L
Sbjct: 440 WTLDDDPILKGGSHRISQM---ITSEGNVVSYLNISSSQVRDGGVYRCTANN--SAGVVL 494
Query: 649 QKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNH 699
+ I +R P +R + + T T + C G P I W+KN++
Sbjct: 495 YQARINVR---GPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSN 542
Score = 62.8 bits (151), Expect = 1e-09
Identities = 143/691 (20%), Positives = 256/691 (37%), Gaps = 120/691 (17%)
Query: 45 AGQTLHLQCRG----EAAHKWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQAN 100
AGQ + L C+ E ++W M + S R T + L + + +
Sbjct: 238 AGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTG-----------LLIENIRPS 286
Query: 101 HTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEI---PEIIHMTEGRELVIP 157
+G Y C+ S + T I GR +V+ + P + + G ++ +
Sbjct: 287 DSGSYVCE-----VSNRYGTAKVI-------GRLYVKQPLKATISPRKVKSSVGSQVSLS 334
Query: 158 CRVTSPNITVTLKKFPLDTLIPDGK--RIIWDSRKGFIISNATYKEIGLLTCEATVNGHL 215
C VT L + ++ GK RI + + I+ + + G C + L
Sbjct: 335 CSVTGTE-DQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKD-KL 392
Query: 216 YKTNYL-------THRQTNTIIDVQISTPRPVKLLRGHTLVLNCTAT-TPLNTRVQMTWS 267
+Y+ T + + + +S PV L+ C TPL T +TW+
Sbjct: 393 SAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLM--------CNVKGTPLPT---ITWT 441
Query: 268 YPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVH 327
D+ + R S N+ S L I Q +D G+Y C + ++
Sbjct: 442 LDDDPILKGGSHRISQMITSEGNVV-SYLNISSSQVRDGGVYRCTANNSAGVVLYQARIN 500
Query: 328 IYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG--LPATEKSARYLT 385
+ A I R + + +AG+ +Y + +V +P + W K+ LP + +
Sbjct: 501 VRGPASI----RPMKNITAIAGRDTY-IHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFEN 555
Query: 386 RGYSLIIKDVTEE-DAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALY 444
G +L + DV +E D G YT + + Q + + + + V V P I FP +
Sbjct: 556 NG-TLKLSDVQKEVDEGEYTCNVLV-QPQLSTSQSVHVTVKVPPFIQP---FEFPR---F 607
Query: 445 PLGSRQILTCTAYGIPQP-TIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIE 503
+G R + C P TI W + R ++G I+
Sbjct: 608 SIGQRVFIPCVVVSGDLPITITW--------QKDGR-------------PIPGSLGVTID 646
Query: 504 SITQRMAIIEGKNKMASTLVVADSRI--SGIYICIASNKVGTVGRNISFYITDVPNGFHV 561
+I S+L +++ + +G Y CIA N+ V S I VP F V
Sbjct: 647 NID-----------FTSSLRISNLSLMHNGNYTCIARNEAAAVEHQ-SQLIVRVPPKFVV 694
Query: 562 N-LEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLN 620
++ G+ + L+C+ + + W + Q +A+ + N
Sbjct: 695 QPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQF------QPIALNGRIQVLSN 748
Query: 621 --LTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAI-SSS 677
L I +V +DSG Y C+ N G ++ + +T++ P ++ + + T+A
Sbjct: 749 GSLLIKHVVEEDSGYYLCKVSN-DVGADVSKSMYLTVK---IPAMITSYPNTTLATQGQK 804
Query: 678 TTLDCHANGVPEPQITWFKNNHKIQQEPELY 708
+ C A+G + W K + I E Y
Sbjct: 805 KEMSCTAHGEKPIIVRWEKEDRIINPEMARY 835
Score = 60.1 bits (144), Expect = 7e-09
Identities = 95/384 (24%), Positives = 145/384 (37%), Gaps = 70/384 (18%)
Query: 299 DKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKA--FITVKHRKQQVLETVAGKRSYRLS 356
D + D+G YTC V P S + SVH+ K FI + + G+R +
Sbjct: 563 DVQKEVDEGEYTCNVLVQPQL-STSQSVHVTVKVPPFI----QPFEFPRFSIGQRVFIPC 617
Query: 357 MKVKAFPSPEVVWLKDGLPATEKSARYLTR---GYSLIIKDVTEEDAGNYTILLSIKQSN 413
+ V + W KDG P + SL I +++ GNYT + + +
Sbjct: 618 VVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAA 677
Query: 414 VFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNH 473
V + LIV V P+ V +Y G IL C+A G P PTI W
Sbjct: 678 VEHQ--SQLIVRVPPKF---VVQPRDQDGIY--GKAVILNCSAEGYPVPTIVW------- 723
Query: 474 NHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIY 533
F A I ++ R+ ++ + + +V DS G Y
Sbjct: 724 ---------------KFSKGAGVPQFQPI-ALNGRIQVLSNGSLLIKHVVEEDS---GYY 764
Query: 534 ICIASNKVGT-------VGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRD 586
+C SN VG + I IT PN + T+G+ ++SCT +
Sbjct: 765 LCKVSNDVGADVSKSMYLTVKIPAMITSYPN------TTLATQGQKKEMSCTAHGEKPII 818
Query: 587 VTWILL-RTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVY--- 642
V W R +N Y +S +++ + L I+ +DSG ++C A N Y
Sbjct: 819 VRWEKEDRIINPEMARYLVSTKEVG----EEVISTLQILPTVREDSGFFSCHAINSYGED 874
Query: 643 ------TGEEILQKKEITIRDQEA 660
T +E EI I+D +A
Sbjct: 875 RGIIQLTVQEPPDPPEIEIKDVKA 898
Score = 34.7 bits (78), Expect = 0.32
Identities = 21/72 (29%), Positives = 28/72 (38%), Gaps = 3/72 (4%)
Query: 634 YACRARNVYTGEEILQKK-EITIRD--QEAPYLLRNLSDHTVAISSSTTLDCHANGVPEP 690
Y C R+ YTGE + + D AP +L L C A G PEP
Sbjct: 195 YRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEP 254
Query: 691 QITWFKNNHKIQ 702
W K+N ++
Sbjct: 255 DYRWLKDNMPLE 266
Score = 32.0 bits (71), Expect = 2.1
Identities = 21/56 (37%), Positives = 28/56 (50%), Gaps = 4/56 (7%)
Query: 355 LSMKVKAFPSPEVVWLKD--GLPA--TEKSARYLTRGYSLIIKDVTEEDAGNYTIL 406
L K PSP V W+KD G P+ T R + S II+ V ED+G Y+ +
Sbjct: 1305 LPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCI 1360
Score = 31.2 bits (69), Expect = 3.6
Identities = 30/122 (24%), Positives = 44/122 (36%), Gaps = 30/122 (24%)
Query: 423 IVNVKPQIYEKA-VSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCD 481
I+ V+P A + +F P +L C A G P P +KW
Sbjct: 1275 IITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWM-------------- 1320
Query: 482 FCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKV 541
DSN + +I R +I + + T+ D SG Y CIA+N
Sbjct: 1321 ------------KDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAED---SGYYSCIANNNW 1365
Query: 542 GT 543
G+
Sbjct: 1366 GS 1367
>gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo
sapiens]
Length = 848
Score = 76.6 bits (187), Expect = 7e-14
Identities = 100/443 (22%), Positives = 162/443 (36%), Gaps = 68/443 (15%)
Query: 294 SVLTIDKMQNKDKGLYTCRVRSGPSFKSVNT-SVHIYDKAFITVKHRKQQVLETVAGKRS 352
S LTI D G+Y C V +S T +V I+ K Q+ E G+ +
Sbjct: 79 STLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFRE---GEDA 135
Query: 353 YRLSMKVKAFPSPEVVWLKDGLPAT-EKSARYLTRGYSLI-IKDVTEEDAGNYTILLSIK 410
+ V + P P ++W G +K R++ + + I+ + + D G Y I
Sbjct: 136 VIVCDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRIL 194
Query: 411 QSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHP 470
+IVNV P I +A + + A LG L C A G P+PT+ W
Sbjct: 195 ARGEINFKDIQVIVNVPPTI--QARQNIVN-ATANLGQSVTLVCDAEGFPEPTMSW---- 247
Query: 471 CNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS 530
+ G +IE I + T+ D
Sbjct: 248 -------------------------TKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDE 282
Query: 531 GIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWI 590
YICIA NK G I + P +V + E + L+C + +TW
Sbjct: 283 AEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITW- 341
Query: 591 LLRTVNNRTMHYSISKQKMA-----ITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGE 645
RT +IS ++ + + H+ +LT+ ++ D+G Y C A N G+
Sbjct: 342 -------RTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNT-IGQ 393
Query: 646 EILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFK--------- 696
+ + + + Q AP L ++ +T + + C P I+WF+
Sbjct: 394 D---SQSMYLEVQYAPKLQGPVAVYTWE-GNQVNITCEVFAYPSATISWFRDGQLLPSSN 449
Query: 697 -NNHKIQQEPEL-YTSTSPSSSS 717
+N KI P Y +P S +
Sbjct: 450 YSNIKIYNTPSASYLEVTPDSEN 472
Score = 64.3 bits (155), Expect = 4e-10
Identities = 51/219 (23%), Positives = 93/219 (42%), Gaps = 29/219 (13%)
Query: 499 GNRIESITQRMAIIEGKNKMASTLVVADSRI--SGIYICIASNKVGT---------VGRN 547
G ++ QR++++ + +STL + ++ I +GIY C+ + + G+ + +
Sbjct: 59 GEKLTPNQQRISVVWNDDS-SSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQK 117
Query: 548 ISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQ 607
+ F P F EGED + C V L + W ++ + K
Sbjct: 118 LMFKNAPTPQEFR--------EGEDAVIVCDVVSSLPPTIIW------KHKGRDVILKKD 163
Query: 608 KMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNL 667
I ++ L I + D GTY C R + GE + ++ + +N+
Sbjct: 164 VRFIVLSNNY---LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNI 220
Query: 668 SDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPE 706
+ T + S TL C A G PEP ++W K+ +I+QE +
Sbjct: 221 VNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259
Score = 56.6 bits (135), Expect = 8e-08
Identities = 96/458 (20%), Positives = 165/458 (36%), Gaps = 62/458 (13%)
Query: 33 ELSLKGTQHIMQAGQTLHLQCR--GEAAHK---WSLP--EMVSKESERLSITKSACGRNG 85
++ + +Q + G++ C+ G+A K W P E ++ +R+S+ +
Sbjct: 21 QVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWN------ 74
Query: 86 KQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEI 145
STLT+ A + G Y C V E+E+ + + I M+ P
Sbjct: 75 DDSSSTLTIYNANIDDAGIYKC---VVTGEDGSESEATVNVKIFQK-----LMFKNAPTP 126
Query: 146 IHMTEGRELVIPCRVTSP-NITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGL 204
EG + VI C V S T+ K D ++ R I S I + G
Sbjct: 127 QEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGT 186
Query: 205 LTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLN-TRVQ 263
CE G + + + I++V ++ ++N TA + T V
Sbjct: 187 YRCE----GRILARGEINFKDIQVIVNVP-------PTIQARQNIVNATANLGQSVTLVC 235
Query: 264 MTWSYPDEKNKRASVRRRIDQSNSHANIFY----SVLTIDKMQNKDKGLYTCRVRSGPSF 319
+P+ +I+Q + S LTI K+ D+ Y C +
Sbjct: 236 DAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGE 295
Query: 320 KSVNTSVHIYDKAFIT-VKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKD--GLPA 376
+ + ++ K IT V+++ LE L+ + P P + W + +
Sbjct: 296 QDATIHLKVFAKPKITYVENQTAMELE-----EQVTLTCEASGDPIPSITWRTSTRNISS 350
Query: 377 TEKS------ARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQI 430
EK+ R R SL +K + DAG Y SN + ++ + V
Sbjct: 351 EEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI----CTASNTIGQDSQSMYLEV---- 402
Query: 431 YEKAVSSFPDPALYPLGSRQI-LTCTAYGIPQPTIKWF 467
+ A A+Y Q+ +TC + P TI WF
Sbjct: 403 -QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWF 439
>gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo
sapiens]
Length = 761
Score = 76.6 bits (187), Expect = 7e-14
Identities = 100/443 (22%), Positives = 162/443 (36%), Gaps = 68/443 (15%)
Query: 294 SVLTIDKMQNKDKGLYTCRVRSGPSFKSVNT-SVHIYDKAFITVKHRKQQVLETVAGKRS 352
S LTI D G+Y C V +S T +V I+ K Q+ E G+ +
Sbjct: 79 STLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFRE---GEDA 135
Query: 353 YRLSMKVKAFPSPEVVWLKDGLPAT-EKSARYLTRGYSLI-IKDVTEEDAGNYTILLSIK 410
+ V + P P ++W G +K R++ + + I+ + + D G Y I
Sbjct: 136 VIVCDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRIL 194
Query: 411 QSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHP 470
+IVNV P I +A + + A LG L C A G P+PT+ W
Sbjct: 195 ARGEINFKDIQVIVNVPPTI--QARQNIVN-ATANLGQSVTLVCDAEGFPEPTMSW---- 247
Query: 471 CNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS 530
+ G +IE I + T+ D
Sbjct: 248 -------------------------TKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDE 282
Query: 531 GIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWI 590
YICIA NK G I + P +V + E + L+C + +TW
Sbjct: 283 AEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITW- 341
Query: 591 LLRTVNNRTMHYSISKQKMA-----ITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGE 645
RT +IS ++ + + H+ +LT+ ++ D+G Y C A N G+
Sbjct: 342 -------RTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNT-IGQ 393
Query: 646 EILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFK--------- 696
+ + + + Q AP L ++ +T + + C P I+WF+
Sbjct: 394 D---SQSMYLEVQYAPKLQGPVAVYTWE-GNQVNITCEVFAYPSATISWFRDGQLLPSSN 449
Query: 697 -NNHKIQQEPEL-YTSTSPSSSS 717
+N KI P Y +P S +
Sbjct: 450 YSNIKIYNTPSASYLEVTPDSEN 472
Score = 64.3 bits (155), Expect = 4e-10
Identities = 51/219 (23%), Positives = 93/219 (42%), Gaps = 29/219 (13%)
Query: 499 GNRIESITQRMAIIEGKNKMASTLVVADSRI--SGIYICIASNKVGT---------VGRN 547
G ++ QR++++ + +STL + ++ I +GIY C+ + + G+ + +
Sbjct: 59 GEKLTPNQQRISVVWNDDS-SSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQK 117
Query: 548 ISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQ 607
+ F P F EGED + C V L + W ++ + K
Sbjct: 118 LMFKNAPTPQEFR--------EGEDAVIVCDVVSSLPPTIIW------KHKGRDVILKKD 163
Query: 608 KMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNL 667
I ++ L I + D GTY C R + GE + ++ + +N+
Sbjct: 164 VRFIVLSNNY---LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNI 220
Query: 668 SDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPE 706
+ T + S TL C A G PEP ++W K+ +I+QE +
Sbjct: 221 VNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259
Score = 56.6 bits (135), Expect = 8e-08
Identities = 96/458 (20%), Positives = 165/458 (36%), Gaps = 62/458 (13%)
Query: 33 ELSLKGTQHIMQAGQTLHLQCR--GEAAHK---WSLP--EMVSKESERLSITKSACGRNG 85
++ + +Q + G++ C+ G+A K W P E ++ +R+S+ +
Sbjct: 21 QVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWN------ 74
Query: 86 KQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEI 145
STLT+ A + G Y C V E+E+ + + I M+ P
Sbjct: 75 DDSSSTLTIYNANIDDAGIYKC---VVTGEDGSESEATVNVKIFQK-----LMFKNAPTP 126
Query: 146 IHMTEGRELVIPCRVTSP-NITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGL 204
EG + VI C V S T+ K D ++ R I S I + G
Sbjct: 127 QEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGT 186
Query: 205 LTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLN-TRVQ 263
CE G + + + I++V ++ ++N TA + T V
Sbjct: 187 YRCE----GRILARGEINFKDIQVIVNVP-------PTIQARQNIVNATANLGQSVTLVC 235
Query: 264 MTWSYPDEKNKRASVRRRIDQSNSHANIFY----SVLTIDKMQNKDKGLYTCRVRSGPSF 319
+P+ +I+Q + S LTI K+ D+ Y C +
Sbjct: 236 DAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGE 295
Query: 320 KSVNTSVHIYDKAFIT-VKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKD--GLPA 376
+ + ++ K IT V+++ LE L+ + P P + W + +
Sbjct: 296 QDATIHLKVFAKPKITYVENQTAMELE-----EQVTLTCEASGDPIPSITWRTSTRNISS 350
Query: 377 TEKS------ARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQI 430
EK+ R R SL +K + DAG Y SN + ++ + V
Sbjct: 351 EEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI----CTASNTIGQDSQSMYLEV---- 402
Query: 431 YEKAVSSFPDPALYPLGSRQI-LTCTAYGIPQPTIKWF 467
+ A A+Y Q+ +TC + P TI WF
Sbjct: 403 -QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWF 439
>gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo
sapiens]
Length = 858
Score = 74.3 bits (181), Expect = 4e-13
Identities = 101/453 (22%), Positives = 163/453 (35%), Gaps = 78/453 (17%)
Query: 294 SVLTIDKMQNKDKGLYTCRVRSGPSFKSVNT-SVHIYDKAFITVKHRKQQVLETVAGKRS 352
S LTI D G+Y C V +S T +V I+ K Q+ E G+ +
Sbjct: 79 STLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFRE---GEDA 135
Query: 353 YRLSMKVKAFPSPEVVWLKDGLPAT-EKSARYLTRGYSLI-IKDVTEEDAGNYTILLSIK 410
+ V + P P ++W G +K R++ + + I+ + + D G Y I
Sbjct: 136 VIVCDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRIL 194
Query: 411 QSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHP 470
+IVNV P I +A + + A LG L C A G P+PT+ W
Sbjct: 195 ARGEINFKDIQVIVNVPPTI--QARQNIVN-ATANLGQSVTLVCDAEGFPEPTMSW---- 247
Query: 471 CNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS 530
+ G +IE I + T+ D
Sbjct: 248 -------------------------TKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDE 282
Query: 531 GIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWI 590
YICIA NK G I + P +V + E + L+C + +TW
Sbjct: 283 AEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITW- 341
Query: 591 LLRTVNNRTMHYSISKQKMA---------------ITKEHSITLNLTIMNVSLQDSGTYA 635
RT +IS ++ A + + H+ +LT+ ++ D+G Y
Sbjct: 342 -------RTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 394
Query: 636 CRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWF 695
C A N G++ + + + Q AP L ++ +T + + C P I+WF
Sbjct: 395 CTASNT-IGQD---SQSMYLEVQYAPKLQGPVAVYTWE-GNQVNITCEVFAYPSATISWF 449
Query: 696 K----------NNHKIQQEPEL-YTSTSPSSSS 717
+ +N KI P Y +P S +
Sbjct: 450 RDGQLLPSSNYSNIKIYNTPSASYLEVTPDSEN 482
Score = 64.3 bits (155), Expect = 4e-10
Identities = 51/219 (23%), Positives = 93/219 (42%), Gaps = 29/219 (13%)
Query: 499 GNRIESITQRMAIIEGKNKMASTLVVADSRI--SGIYICIASNKVGT---------VGRN 547
G ++ QR++++ + +STL + ++ I +GIY C+ + + G+ + +
Sbjct: 59 GEKLTPNQQRISVVWNDDS-SSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQK 117
Query: 548 ISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQ 607
+ F P F EGED + C V L + W ++ + K
Sbjct: 118 LMFKNAPTPQEFR--------EGEDAVIVCDVVSSLPPTIIW------KHKGRDVILKKD 163
Query: 608 KMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNL 667
I ++ L I + D GTY C R + GE + ++ + +N+
Sbjct: 164 VRFIVLSNNY---LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNI 220
Query: 668 SDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPE 706
+ T + S TL C A G PEP ++W K+ +I+QE +
Sbjct: 221 VNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259
Score = 53.1 bits (126), Expect = 9e-07
Identities = 96/468 (20%), Positives = 166/468 (35%), Gaps = 72/468 (15%)
Query: 33 ELSLKGTQHIMQAGQTLHLQCR--GEAAHK---WSLP--EMVSKESERLSITKSACGRNG 85
++ + +Q + G++ C+ G+A K W P E ++ +R+S+ +
Sbjct: 21 QVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWN------ 74
Query: 86 KQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEI 145
STLT+ A + G Y C V E+E+ + + I M+ P
Sbjct: 75 DDSSSTLTIYNANIDDAGIYKC---VVTGEDGSESEATVNVKIFQK-----LMFKNAPTP 126
Query: 146 IHMTEGRELVIPCRVTSP-NITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGL 204
EG + VI C V S T+ K D ++ R I S I + G
Sbjct: 127 QEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGT 186
Query: 205 LTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLN-TRVQ 263
CE G + + + I++V ++ ++N TA + T V
Sbjct: 187 YRCE----GRILARGEINFKDIQVIVNVP-------PTIQARQNIVNATANLGQSVTLVC 235
Query: 264 MTWSYPDEKNKRASVRRRIDQSNSHANIFY----SVLTIDKMQNKDKGLYTCRVRSGPSF 319
+P+ +I+Q + S LTI K+ D+ Y C +
Sbjct: 236 DAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGE 295
Query: 320 KSVNTSVHIYDKAFIT-VKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKD--GLPA 376
+ + ++ K IT V+++ LE L+ + P P + W + +
Sbjct: 296 QDATIHLKVFAKPKITYVENQTAMELE-----EQVTLTCEASGDPIPSITWRTSTRNISS 350
Query: 377 TEKSA----------------RYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA 420
EK++ R R SL +K + DAG Y SN +
Sbjct: 351 EEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYI----CTASNTIGQDSQ 406
Query: 421 TLIVNVKPQIYEKAVSSFPDPALYPLGSRQI-LTCTAYGIPQPTIKWF 467
++ + V + A A+Y Q+ +TC + P TI WF
Sbjct: 407 SMYLEV-----QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWF 449
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.130 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,386,837
Number of Sequences: 37866
Number of extensions: 1245008
Number of successful extensions: 14320
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 245
Number of HSP's successfully gapped in prelim test: 154
Number of HSP's that attempted gapping in prelim test: 7699
Number of HSP's gapped (non-prelim): 4474
length of query: 733
length of database: 18,247,518
effective HSP length: 110
effective length of query: 623
effective length of database: 14,082,258
effective search space: 8773246734
effective search space used: 8773246734
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.