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Search of human proteins with 226509740
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens]
(1312 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens] 2636 0.0
gi|221139764 PHD and ring finger domains 1 [Homo sapiens] 176 2e-43
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 126 1e-28
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens] 126 2e-28
gi|117676384 splicing factor, arginine/serine-rich 2, interactin... 124 6e-28
gi|163965366 nascent polypeptide-associated complex alpha subuni... 103 1e-21
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 97 8e-20
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 97 8e-20
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 97 1e-19
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 97 1e-19
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 95 4e-19
gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens] 95 4e-19
gi|158854042 hypothetical protein LOC222183 [Homo sapiens] 92 3e-18
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 91 6e-18
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens] 89 2e-17
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 88 6e-17
gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens] 86 3e-16
gi|239758013 PREDICTED: hypothetical protein [Homo sapiens] 84 7e-16
gi|149158690 HLA-B associated transcript-2 [Homo sapiens] 83 2e-15
gi|224548936 hypothetical protein LOC100170229 [Homo sapiens] 83 2e-15
gi|50962882 G patch domain containing 8 [Homo sapiens] 83 2e-15
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens] 82 3e-15
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens] 82 3e-15
gi|133922600 splicing factor, arginine/serine-rich 16 [Homo sapi... 81 6e-15
gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo sapi... 80 1e-14
gi|33356174 pinin, desmosome associated protein [Homo sapiens] 80 2e-14
gi|42741684 zinc finger protein 265 isoform 1 [Homo sapiens] 80 2e-14
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 79 2e-14
gi|186700623 Rab-like GTP-binding protein 1 isoform 1 [Homo sapi... 78 6e-14
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 78 6e-14
>gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens]
Length = 1312
Score = 2636 bits (6833), Expect = 0.0
Identities = 1312/1312 (100%), Positives = 1312/1312 (100%)
Query: 1 MEEEDESRGKTEESGEDRGDGPPDRDPTLSPSAFILRAIQQAVGSSLQGDLPNDKDGSRC 60
MEEEDESRGKTEESGEDRGDGPPDRDPTLSPSAFILRAIQQAVGSSLQGDLPNDKDGSRC
Sbjct: 1 MEEEDESRGKTEESGEDRGDGPPDRDPTLSPSAFILRAIQQAVGSSLQGDLPNDKDGSRC 60
Query: 61 HGLRWRRCRSPRSEPRSQESGGTDTATVLDMATDSFLAGLVSVLDPPDTWVPSRLDLRPG 120
HGLRWRRCRSPRSEPRSQESGGTDTATVLDMATDSFLAGLVSVLDPPDTWVPSRLDLRPG
Sbjct: 61 HGLRWRRCRSPRSEPRSQESGGTDTATVLDMATDSFLAGLVSVLDPPDTWVPSRLDLRPG 120
Query: 121 ESEDMLELVAEVRIGDRDPIPLPVPSLLPRLRAWRTGKTVSPQSNSSRPTCARHLTLGTG 180
ESEDMLELVAEVRIGDRDPIPLPVPSLLPRLRAWRTGKTVSPQSNSSRPTCARHLTLGTG
Sbjct: 121 ESEDMLELVAEVRIGDRDPIPLPVPSLLPRLRAWRTGKTVSPQSNSSRPTCARHLTLGTG 180
Query: 181 DGGPAPPPAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEAYSP 240
DGGPAPPPAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEAYSP
Sbjct: 181 DGGPAPPPAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEAYSP 240
Query: 241 PPAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISET 300
PPAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISET
Sbjct: 241 PPAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISET 300
Query: 301 LAGIYDDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAE 360
LAGIYDDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAE
Sbjct: 301 LAGIYDDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAE 360
Query: 361 ACREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPT 420
ACREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPT
Sbjct: 361 ACREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPT 420
Query: 421 PAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGGL 480
PAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGGL
Sbjct: 421 PAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGGL 480
Query: 481 DLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQ 540
DLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQ
Sbjct: 481 DLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQ 540
Query: 541 PAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRS 600
PAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRS
Sbjct: 541 PAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRS 600
Query: 601 RSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSE 660
RSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSE
Sbjct: 601 RSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSE 660
Query: 661 KAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSP 720
KAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSP
Sbjct: 661 KAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSP 720
Query: 721 APASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDR 780
APASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDR
Sbjct: 721 APASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDR 780
Query: 781 DRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSSSSSCSSRKVKLQSKVAVL 840
DRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSSSSSCSSRKVKLQSKVAVL
Sbjct: 781 DRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSSSSSCSSRKVKLQSKVAVL 840
Query: 841 IREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDERAPTEMAKAAPGSTKPKKT 900
IREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDERAPTEMAKAAPGSTKPKKT
Sbjct: 841 IREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDERAPTEMAKAAPGSTKPKKT 900
Query: 901 KVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKKSKADSCSQAAGTKGAE 960
KVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKKSKADSCSQAAGTKGAE
Sbjct: 901 KVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKKSKADSCSQAAGTKGAE 960
Query: 961 ETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTVDSSCKTPEVSFLPEEATEEAGVRGG 1020
ETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTVDSSCKTPEVSFLPEEATEEAGVRGG
Sbjct: 961 ETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTVDSSCKTPEVSFLPEEATEEAGVRGG 1020
Query: 1021 AEEEEEEEEEEEEEEEEEEQQPATTTATSTAAAAPSTAPSAGSTAGDSGAEDGPASRVSQ 1080
AEEEEEEEEEEEEEEEEEEQQPATTTATSTAAAAPSTAPSAGSTAGDSGAEDGPASRVSQ
Sbjct: 1021 AEEEEEEEEEEEEEEEEEEQQPATTTATSTAAAAPSTAPSAGSTAGDSGAEDGPASRVSQ 1080
Query: 1081 LPTLPPPMPWNLPAGVDCTTSGVLALTALLFKMEEANLASRAKAQELIQATNQILSHRKP 1140
LPTLPPPMPWNLPAGVDCTTSGVLALTALLFKMEEANLASRAKAQELIQATNQILSHRKP
Sbjct: 1081 LPTLPPPMPWNLPAGVDCTTSGVLALTALLFKMEEANLASRAKAQELIQATNQILSHRKP 1140
Query: 1141 PSSLGMTPAPVPTSLGLPPGPSSYLLPGSLPLGGCGSTPPTPTGLAATSDKREGSSSSEG 1200
PSSLGMTPAPVPTSLGLPPGPSSYLLPGSLPLGGCGSTPPTPTGLAATSDKREGSSSSEG
Sbjct: 1141 PSSLGMTPAPVPTSLGLPPGPSSYLLPGSLPLGGCGSTPPTPTGLAATSDKREGSSSSEG 1200
Query: 1201 RGDTDKYLKKLHTQERAVEEVKLAIKPYYQKKDITKEEYKDILRKAVHKICHSKSGEINP 1260
RGDTDKYLKKLHTQERAVEEVKLAIKPYYQKKDITKEEYKDILRKAVHKICHSKSGEINP
Sbjct: 1201 RGDTDKYLKKLHTQERAVEEVKLAIKPYYQKKDITKEEYKDILRKAVHKICHSKSGEINP 1260
Query: 1261 VKVSNLVRAYVQRYRYFRKHGRKPGDPPGPPRPPKEPGPPDKGGPGLPLPPL 1312
VKVSNLVRAYVQRYRYFRKHGRKPGDPPGPPRPPKEPGPPDKGGPGLPLPPL
Sbjct: 1261 VKVSNLVRAYVQRYRYFRKHGRKPGDPPGPPRPPKEPGPPDKGGPGLPLPPL 1312
>gi|221139764 PHD and ring finger domains 1 [Homo sapiens]
Length = 1648
Score = 176 bits (445), Expect = 2e-43
Identities = 229/836 (27%), Positives = 315/836 (37%), Gaps = 143/836 (17%)
Query: 513 PPTRKKSRRERKRSGEAKEAASSSSGTQPAP----------PAPASPWDSKKHRSRDRKP 562
PP S + R A E AS + +P P+P PWD +
Sbjct: 893 PPLGPSSAMSKLRGAVAAEGASDTEREEPTESQGLAARLRRPSPPEPWDEE--------- 943
Query: 563 GSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPATSSS 622
AS S S R+ + T + S + R PP+ S S
Sbjct: 944 -DGASCSTFFGSEERTVTCVTVVEPEAPP--------SPDVLQAATHRVVELRPPSRSRS 994
Query: 623 SSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRR 682
+SS R R + K +K+ SR G RSG SE + S S S G+ RR
Sbjct: 995 TSSSRSRKKAK---------RKRVSREHGRTRSGTRSESRDRSSR--SASPSVGEERPRR 1043
Query: 683 RGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLSGEER 742
+ + S + +D + +R DKS P S S G S E
Sbjct: 1044 QRSKAKSRRSSSDRSS-SRERAKRKKAKDKSREHRRGPWGHSRRTSRSRSGSPGSSSYEH 1102
Query: 743 GGKSSQKDRRRS----GAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDRSSKKARPP 798
+K RR + G S +SS E+ R K R+R +R DR A P
Sbjct: 1103 YESRKKKKRRSASRPRGRECSPTSSLERLCRHK------HQRERSHERP-DRKESVAWPR 1155
Query: 799 KESAPSSGPPPKPPVSSGSGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAG 858
S P SS + R+ + + K ++A+ A
Sbjct: 1156 DRRKRRSRSP-----------SSEHRAREHRRPRSREKWPQTRSHSPERKGAVREASPAP 1204
Query: 859 LGSIGVKFSRDRESRSPFLKPDERAPTEMAKAAPGSTKPKKTKVKAKAGAKKTKGTKGKT 918
L G D +R P L +P E+A A KA A +
Sbjct: 1205 LAQ-GEPGREDLPTRLPALGEAHVSP-EVATAD-----------KAPLQAPPVLEVAAEC 1251
Query: 919 KPSKTRKKVRSGGGSGGSGGQVSLKKSKADSCSQAAGTKGAEETSWSGEERAAKVPSTPP 978
+P G V D S A + + +S E + P
Sbjct: 1252 EPDDLDLDY---------GDSVEAGHVFDDFSSDAVFIQLDDMSSPPSPEST----DSSP 1298
Query: 979 PKAAPPPPALTPDSQTVDSSCKTPEVSFLPEEATEEAGVRGGAEEEEEEEEEEEEEEEEE 1038
+ P PAL P S V + + EVS + +E + +E + E+ E
Sbjct: 1299 ERDFPLKPALPPASLAVAAIQR--EVSLMHDEDPSQPPPLPEGTQEPHLLRPDAAEKAEA 1356
Query: 1039 EQQPATTTATSTAAAAPSTAPSAGSTAGDSGAEDGPASRVSQLP-----TLPPPMPWNLP 1093
P A A +PSA ++ P VSQ P L + WNL
Sbjct: 1357 PSSP------DVAPAGKEDSPSASGRVQEAAR---PEEVVSQTPLLRSRALVKRVTWNLQ 1407
Query: 1094 AGVDCTTSGVLALTALLFKMEEANLASRAKAQELIQATNQILSHRKPPSSLGMTPAPVPT 1153
+ A A L + ++ + Q+ S PS + P T
Sbjct: 1408 ESESSAPAEDRAPRAPLHRPQKPREGAWDMEDVAPTGVRQVFSELPFPSHVLPEPGFPDT 1467
Query: 1154 ------SLGLPPGPSS----------------YLLPGSLPLGGCGSTP---PTPTGLAAT 1188
S GLPP P+ ++L GSLPL GCG+ P P L
Sbjct: 1468 DPSQVYSPGLPPAPAQPSSIPPCALVSQPTVQFILQGSLPLVGCGAAQTLAPVPAALTPA 1527
Query: 1189 SD---KREGSSSSEGRGDT----------DKYLKKLHTQERAVEEVKLAIKPYYQKKDIT 1235
S+ + +S+SE + ++Y+KKLH QERAVEEVKLAIKP+YQK+++T
Sbjct: 1528 SEPASQATAASNSEEKTPAPRLAAEKTKKEEYMKKLHMQERAVEEVKLAIKPFYQKREVT 1587
Query: 1236 KEEYKDILRKAVHKICHSKSGEINPVKVSNLVRAYVQRYRYFRKHGRKPGDPPGPP 1291
KEEYKDILRKAV KICHSKSGEINPVKV+NLV+AYV +YR+ R+H +KP PP
Sbjct: 1588 KEEYKDILRKAVQKICHSKSGEINPVKVANLVKAYVDKYRHMRRH-KKPEAGEEPP 1642
Score = 72.0 bits (175), Expect = 3e-12
Identities = 124/550 (22%), Positives = 193/550 (35%), Gaps = 93/550 (16%)
Query: 163 QSNSSRPTCARHLTLGTGDGGPAPPPAPSSASSSPSPSPSS--SSPSPPPPPPPPAPPAP 220
QS C LT G G P S +SS P + S PP P AP
Sbjct: 701 QSIEIPSACISRLTGREGTGQPGRGTRAESEASSRVPREPGVHTGSSRPPAPSSHGSLAP 760
Query: 221 PAPR--------FDIYDPFHPTDEAYSPPPAPEQKYDPFEPTGSNPSSSAGTPSPEEEEE 272
P F+ + P + A+S + + F P
Sbjct: 761 LGPSRGKGVGSTFESFRINIPGNMAHSSQLSSPGFCNTFRPV------------------ 802
Query: 273 EEEEEEEEEEDEEEEEGLSQSISRISETLAGIYDDNSLSQDFPGDESPRPDAQPTQPTPA 332
+++E +E SI + + + +YD + D G +S P + P + P
Sbjct: 803 ------DDKEQRKENPSPLFSIKKTKQLRSEVYDPS----DPTGSDSSAPGSSPERSGPG 852
Query: 333 PGTPPQVDSTRADGAMRRRVFVVGTEAEACREGKVSVEVVTAGGAALPPPLLPPGDSEIE 392
P ++ T + + + + +A C S V + G PPL P
Sbjct: 853 L-LPSEITRTISINSPKAQT----VQAVRC---VTSYTVESIFGTEPEPPLGPSSAMSKL 904
Query: 393 EGEIV----------QPEEEPRLALSLFRP----------GGRAARPTPAASATPTAQPL 432
G + +P E LA L RP G + + T T +
Sbjct: 905 RGAVAAEGASDTEREEPTESQGLAARLRRPSPPEPWDEEDGASCSTFFGSEERTVTCVTV 964
Query: 433 PQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGGLDLRRKILTQR-R 491
+P AP +P+ L A + V+L P+ + + SR R+++ + R
Sbjct: 965 VEPEAPPSPD-----VLQAATHRV----VELRPPSRSRSTSSSRSRKKAKRKRVSREHGR 1015
Query: 492 ERYRQRSPS---PAPAPAPAAAAGPPTRKKSRRERKRSGE----AKEAASSSSGTQPAPP 544
R RS S + + +P+ P R++S+ + +RS ++E A +
Sbjct: 1016 TRSGTRSESRDRSSRSASPSVGEERPRRQRSKAKSRRSSSDRSSSRERAKRKKAKDKSRE 1075
Query: 545 APASPWDSKKHRSRDRKPGSHASSS---------ARRRSRSRSRSRSTRRRSRSTDRRRG 595
PW + SR R GS SSS +RRS SR R R S R
Sbjct: 1076 HRRGPWGHSRRTSRSRS-GSPGSSSYEHYESRKKKKRRSASRPRGRECSPTSSLERLCRH 1134
Query: 596 GSRRSRSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRS 655
+R RS E+ R+ A P S S HR + S++K ++RS +R
Sbjct: 1135 KHQRERSHERPDRKESVAWPRDRRKRRSRSPSSEHRAREHRRPRSREKWPQTRSHSPERK 1194
Query: 656 GDGSEKAPAP 665
G E +PAP
Sbjct: 1195 GAVREASPAP 1204
Score = 44.3 bits (103), Expect = 8e-04
Identities = 77/322 (23%), Positives = 110/322 (34%), Gaps = 63/322 (19%)
Query: 194 SSSPSPSPSSSSPS---PPPPPPPPAPPAPPAPRFDIYDPFHPTDEAYSPPPAPEQKYDP 250
SS PSP + SSP P P PPA A A + ++ H D + PPP PE +P
Sbjct: 1286 SSPPSPESTDSSPERDFPLKPALPPASLAVAAIQREV-SLMHDEDPS-QPPPLPEGTQEP 1343
Query: 251 --FEPTGSNPSSSAGTP--SPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISETLAGIYD 306
P + + + +P +P +E+ +E EE +SQ+ S L
Sbjct: 1344 HLLRPDAAEKAEAPSSPDVAPAGKEDSPSASGRVQEAARPEEVVSQTPLLRSRALVKRVT 1403
Query: 307 DNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAEACREGK 366
N + +P D P P P P REG
Sbjct: 1404 WNLQESE---SSAPAEDRAPRAPLHRPQKP--------------------------REGA 1434
Query: 367 VSVEVVTAGGA-------ALPPPLLP-PGDSEIEEGEIVQPEEEPRLAL-SLFRPGGRAA 417
+E V G P +LP PG + + ++ P P A S P +
Sbjct: 1435 WDMEDVAPTGVRQVFSELPFPSHVLPEPGFPDTDPSQVYSPGLPPAPAQPSSIPPCALVS 1494
Query: 418 RPTP---AASATP-----TAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPA 469
+PT + P AQ L PA P + A S+ E E PA
Sbjct: 1495 QPTVQFILQGSLPLVGCGAAQTLAPVPAALTPASEPASQATAASNSE--------EKTPA 1546
Query: 470 PPAADSRWGGLDLRRKILTQRR 491
P A + + +K+ Q R
Sbjct: 1547 PRLAAEKTKKEEYMKKLHMQER 1568
Score = 41.6 bits (96), Expect = 0.005
Identities = 168/861 (19%), Positives = 281/861 (32%), Gaps = 157/861 (18%)
Query: 502 APAPAPAAAAGPPTRKK-----------SRRERKRSGEAKEAASSSSGTQPAPPAPASPW 550
AP AA AGP + ++ + R R R+G + A + + +
Sbjct: 232 APGVVLAADAGPVSEEEVSLLLADVVPTTSRLRPRAGRTRAIARTRQSERVRATVNRNRI 291
Query: 551 DSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRR--R 608
+ R PG SS + + ST R R R+ ++R +++
Sbjct: 292 STA--RRVQHTPGRLGSSLLDEAIEAVATGLSTAVYQRPLTPRTPARRKRKTRRRKKVPG 349
Query: 609 RRRSASPPPATSSSSS--SRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPA 666
R+++ S P A S SS+ S++ +HR K R G KK K + +R G +
Sbjct: 350 RKKTPSGPSAKSKSSATRSKKRQHRVKKRRG---KKVKSEATTRSRIARTLGLRRPV--- 403
Query: 667 PPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDK-SDPRGPSPAPASS 725
+SC PS+ + L ++ I L DP P
Sbjct: 404 -----HSSC-----------IPSVLKPVEPSLGLLRADIGAASLSLFGDPYELDP----- 442
Query: 726 PKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRD 785
+DSE LS S+++ A S S+ + R G R R
Sbjct: 443 ------FDSEELSANPLSPLSAKR-----RALSRSALQSHQPVARPVSVGLSRRR----- 486
Query: 786 RDRDRSSKKARPPKESAPSSGPPP---KPPVSSGSGSSSSSSSCSSRKVKLQSKVAVLIR 842
P++ P P + PV GS S S + L S ++ R
Sbjct: 487 ----------------LPAAVPEPDLEEEPVPDLLGSILSGQSL----LMLGSSDVIIHR 526
Query: 843 EGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDERAPTEMAKAAPGSTKPKKTKV 902
+G S AK AA SR E L+P P+ P +P+ T +
Sbjct: 527 DGSLS---AKRAAPVSFQRNSGSLSRGEEGFKGCLQP-RALPSGSPAQGPSGNRPQSTGL 582
Query: 903 KAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKKSKADSCSQAAGTKGAEET 962
+ ++ T G P + G + S+ + GT
Sbjct: 583 SCQGRSRTPARTAG--APVRLDLPAAPGAVQARNLSNGSVPGFRQSHSPWFNGTNKHTLP 640
Query: 963 SWSGEERAAKVPSTPPPKAAPPPPALTPDSQTVDSSCKTPEVSFLPEEATEEAGVRGGAE 1022
S + + S PP ++ P P L P + D S E+ +P+ ++ G R A
Sbjct: 641 LASAASKISSRDSKPPCRSVVPGPPLKPAPRRTDIS----ELPRIPKIRRDDGGGRRDAA 696
Query: 1023 EEEEEEEE------EEEEEEEEEQQPATTTATSTAAAAPSTAPSAGSTAGDSGAEDGPAS 1076
+ E E QP T + A+ S P S P+S
Sbjct: 697 PAHGQSIEIPSACISRLTGREGTGQPGRGTRAESEAS--SRVPREPGVHTGSSRPPAPSS 754
Query: 1077 RVSQLPTLPP--------------PMPWNLPAGVDCTTSGVLALTALLFKMEE--ANLAS 1120
S P P +P N+ ++ G + E+ N +
Sbjct: 755 HGSLAPLGPSRGKGVGSTFESFRINIPGNMAHSSQLSSPGFCNTFRPVDDKEQRKENPSP 814
Query: 1121 RAKAQELIQATNQILSHRKPPSSLGMTP--APVPTSLGLPPGPSSYLLPGSLPLGGC--- 1175
++ Q +++ P S P +P + GL P + + + P
Sbjct: 815 LFSIKKTKQLRSEVYDPSDPTGSDSSAPGSSPERSGPGLLPSEITRTISINSPKAQTVQA 874
Query: 1176 -------------GSTPPTPTGLAATSDKREGSSSSEGRGDTDK-----------YLKKL 1211
G+ P P G ++ K G+ ++EG DT++ L++
Sbjct: 875 VRCVTSYTVESIFGTEPEPPLGPSSAMSKLRGAVAAEGASDTEREEPTESQGLAARLRRP 934
Query: 1212 HTQERAVEEVKLAIKPYYQKKDIT----------KEEYKDILRKAVHKICHSKSGEINPV 1261
E EE + ++ ++ T D+L+ A H++ + +
Sbjct: 935 SPPEPWDEEDGASCSTFFGSEERTVTCVTVVEPEAPPSPDVLQAATHRVVELRPPSRSRS 994
Query: 1262 KVSNLVRAYVQRYRYFRKHGR 1282
S+ R +R R R+HGR
Sbjct: 995 TSSSRSRKKAKRKRVSREHGR 1015
Score = 33.9 bits (76), Expect = 1.1
Identities = 43/199 (21%), Positives = 57/199 (28%), Gaps = 55/199 (27%)
Query: 187 PPAPSSASSSPSPSPSSSSPSPP-------------------PPPPPPAPPAPPAPRFDI 227
PP+P S SSP PP P PPP P P
Sbjct: 1288 PPSPESTDSSPERDFPLKPALPPASLAVAAIQREVSLMHDEDPSQPPPLPEGTQEPHLLR 1347
Query: 228 YDPFHPTDEAYSPPPAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEE----------- 276
D + SP AP K D +PS+S EE +
Sbjct: 1348 PDAAEKAEAPSSPDVAPAGKED-------SPSASGRVQEAARPEEVVSQTPLLRSRALVK 1400
Query: 277 ------EEEEEEDEEEEEGLSQSISRISETLAGIYDDNSLSQ----------DFPGDESP 320
+E E E+ + R + G +D ++ FP P
Sbjct: 1401 RVTWNLQESESSAPAEDRAPRAPLHRPQKPREGAWDMEDVAPTGVRQVFSELPFPSHVLP 1460
Query: 321 RPDAQPTQPTP--APGTPP 337
P T P+ +PG PP
Sbjct: 1461 EPGFPDTDPSQVYSPGLPP 1479
Score = 30.8 bits (68), Expect = 8.9
Identities = 22/99 (22%), Positives = 37/99 (37%), Gaps = 15/99 (15%)
Query: 237 AYSPPPAPEQKYDPFEPTGSNPSSSAGTPSP---------------EEEEEEEEEEEEEE 281
A SP P + P +P G SS G+ E+E EEE+ E+
Sbjct: 11 ARSPGPDGHPQVGPADPAGDFEESSVGSSGDSGDDSDSEHGDGTDGEDEGASEEEDLEDR 70
Query: 282 EDEEEEEGLSQSISRISETLAGIYDDNSLSQDFPGDESP 320
E+ E +++ ++ T + S + D + P
Sbjct: 71 SGSEDSEDDGETLLEVAGTQGKLEAAGSFNSDDDAESCP 109
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 126 bits (317), Expect = 1e-28
Identities = 245/1003 (24%), Positives = 365/1003 (36%), Gaps = 133/1003 (13%)
Query: 181 DGGPAPPPAPSSASSSPSPSP---------SSSSPSPPPPPPPPAPPAPPAPRFDIYDPF 231
DG P + + P+P P SSSS SP P R + P
Sbjct: 147 DGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPR 206
Query: 232 HPTDEAY------SPPPAPEQKYDPFEPTGSNPS-------SSAGTPSPEEEEEEEEEEE 278
++ S + ++K+ P S S + TP+P+
Sbjct: 207 RERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSA 266
Query: 279 EEEEDEEEEEGLSQSISRISET--LAGIYDDNSLSQDFPGDES-PRPDAQPTQPTPAPGT 335
+ + S+S + + T LAG + + GD P TQ +P T
Sbjct: 267 DSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPET 326
Query: 336 PPQVDSTRADGAMRRRVFVVGTEAEACREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGE 395
+ S+ + + + E A R T P PLL G
Sbjct: 327 ATKQPSSPYEDKDKDK-----KEKSATRPSPSPERSSTGPEPPAPTPLLAE-----RHGG 376
Query: 396 IVQPEEEPRLALSLFRPGGRAARPTPAASATPTAQPLPQ-------PPAPRAPEGDDFLS 448
QP L+ P A+ PT S + + LPQ PP+P+ + +S
Sbjct: 377 SPQPLATTPLSQEPVNPPSEAS-PTRDRSPPKSPEKLPQSSSSESSPPSPQPTK----VS 431
Query: 449 LHAESDGEGALQVDLGEPAPAP---------PAADSRWGGLDLRRKILTQRRERYRQRSP 499
HA S E +PAPAP P + +R G R K + R RS
Sbjct: 432 RHASSSPESP------KPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSR 485
Query: 500 SPAPAPAPAAAAGPPTRKKSRRER----KRSGEAKEAASSSS----GTQPAPPAPA---S 548
SPA A + + PT++ R R +RS A+ S S G +P P S
Sbjct: 486 SPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRS 545
Query: 549 PWDSKKHRSRDRKPGSHASSSARRRSRSRSR--SRSTRRRSRSTDRRRGGS-----RRSR 601
++ RSR + G S S R RSRSR +R R RSR+ RRR S RRSR
Sbjct: 546 RNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSR 605
Query: 602 SREKRRR-RRRSASPPPATSSSSS--SRRERHRGKHRDGGGSKK----KKKRSRSRGEKR 654
SR RR R RS +P S + S RR R R R G S+ ++ RSRSR R
Sbjct: 606 SRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPAR 665
Query: 655 SGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSD 714
G + PA S S + R R R P + + + + GR
Sbjct: 666 RGRSRSRTPARRSGRSRSRTPA-RRGRSRSRTPRRGRSRS-------RSLVRRGRSHSRT 717
Query: 715 PRGPSPAPASSPKREVLYDSEGLSGEERG---GKSSQKDRRRSGAASSSSSSREKGSRRK 771
P+ + +SS ++ S+ S KS RR +S S ++ + S R+
Sbjct: 718 PQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRR 777
Query: 772 ALDG--------GDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSSS 823
+L G R R +K PP+ S SS PPPK + S S SS
Sbjct: 778 SLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSS 837
Query: 824 SSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFSRDRE--SRSPF----- 876
SS KVK + R+G ++ A + + + S D E SR+P
Sbjct: 838 SS-PHPKVKSGTPP----RQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCS 892
Query: 877 -LKPDERAPTEMAKAAPGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGG 935
P + + +P + + KVKA ++ + G + PS +R R+
Sbjct: 893 GSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQ-RSHSGSSSPSPSRVTSRTTPRRSR 951
Query: 936 SGGQVSLKKSK-----ADSCSQAAGTKGAEETSWSGEERAAKVPSTPPPKA-APPPPALT 989
S S +S+ + S S + TK ET + + + P KA PP P+L+
Sbjct: 952 SVSPCSNVESRLLPRYSHSGSSSPDTKVKPETP-PRQSHSGSISPYPKVKAQTPPGPSLS 1010
Query: 990 -PDSQTVDSSCKTPEVSFLPEEATEEAGVRGGAEEEEE---EEEEEEEEEEEEEQQPATT 1045
S K V P + AGV+ E + + + + +
Sbjct: 1011 GSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSPDHRSD 1070
Query: 1046 TATSTAAAAPSTAPSAGSTAGDS--GAEDGPASRVSQLPTLPP 1086
T++ + S +PS S + S G +S V++L + P
Sbjct: 1071 TSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSP 1113
Score = 112 bits (281), Expect = 2e-24
Identities = 241/1021 (23%), Positives = 355/1021 (34%), Gaps = 154/1021 (15%)
Query: 143 PVPSLLPRLRAWRTGKTVSPQSNSSRPTCARHLTLGTGDGGPAPPPAPSSASSSPSPSPS 202
P P R+ S ++ SR A T T G +P PA +P
Sbjct: 253 PAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSE 312
Query: 203 SSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEAYSPPPAPEQKY---DPFEPT----- 254
+ S P P P+ ++ D A P P+PE+ +P PT
Sbjct: 313 PGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAE 372
Query: 255 --GSNPSSSAGTPSPEE--EEEEEEEEEEEEEDEEEEEGLSQSISRISETLAGIYDDNSL 310
G +P A TP +E E + + E L QS S ++S
Sbjct: 373 RHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSS----------SESSP 422
Query: 311 SQDFPGDESPRPDAQP--TQPTPAPGTPPQVDST-----RADGAMR----------RRVF 353
P S + P +P PAPG+ ++ S+ R+ G + RR+
Sbjct: 423 PSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMG 482
Query: 354 VVGTEAEACREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPG 413
+ A A R S G + P S G P+ R + S RPG
Sbjct: 483 RSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGR-SRSPQRPG 541
Query: 414 GRAARPTPAASATPTA---QPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAP 470
+R T + +A + + PA R + S + P
Sbjct: 542 WSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTR 601
Query: 471 PAADSRWGGLDLRRKILTQRRERYRQRSP--SPAPAPAPAAAAG-PPTRKKSRRERKRSG 527
+ SR R + T R R R RSP + + +PA +G +R +RR R RS
Sbjct: 602 RRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSR 661
Query: 528 EAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRS 587
S S T PA + RSR R P S +R R RSRSRS RR
Sbjct: 662 TPARRGRSRSRT-PA---------RRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRG 711
Query: 588 RS---TDRRRGGSRRSRSREKR----RRRRRSASPPPATSSSSSSRRERHRGKHRDGGGS 640
RS T +RRG S S R+ + +RR RS S P S SSRR R R S
Sbjct: 712 RSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKS 771
Query: 641 KKKKKRSRSRG-------------EKRSGDGSEKA----------PAPAPPPSGSTSCGD 677
+ +RS S RSG KA + +PPP +
Sbjct: 772 RLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPS 831
Query: 678 RDSRRRGAVPPSIQDLTDHDLFAI------KRTITVGRL----DKSDPRGPSPAPA---- 723
R S + P ++ T +I ++++T R DP S P+
Sbjct: 832 RQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSC 891
Query: 724 --SSPKREVLYDSEGLSGEERGGKSSQK------DRRRSGAASSSSS-----SREKGSRR 770
SSP R V + R K R+RS + SSS S SR R
Sbjct: 892 SGSSPPR-VKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRS 950
Query: 771 KALDGGDRDRDRDRDR-------DRDRSSKKARPPKES-APSSGPPPK-----PPVSSGS 817
+++ R R D K PP++S + S P PK PP S S
Sbjct: 951 RSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPGPSLS 1010
Query: 818 GSSSSSSSCSSRKVKLQSKVAVL-IREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPF 876
GS S S+ +QS L + GV S+TP + + G+ S+ +K + SP
Sbjct: 1011 GSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGE-SYFGVSSLQLK---GQSQTSPD 1066
Query: 877 LKPDERAPTEMAKAAPGSTKPKKTKVKAKAGAKKTKG---TKGKTKPSKTRKKVRSGGGS 933
+ D +P + + K++ K G ++ P + + S
Sbjct: 1067 HRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSASPM 1126
Query: 934 GGSGGQVSLKKSKADSC-------------SQAAGTKGAEETSWSGEERAAKVPSTPPPK 980
SG + ++DS S+ + E+ + +E A P K
Sbjct: 1127 LKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDATASPPRQKDK 1186
Query: 981 AAPPPPALTPDSQTV-DSSCKTPE-----VSFLPEEATEEAGVRGGAEEEEEEEEEEEEE 1034
+P P P+S V + +TP PE + + + +++EE E E+ E
Sbjct: 1187 FSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPETKEQNSALPTSSQDEELMEVVEKSE 1246
Query: 1035 E 1035
E
Sbjct: 1247 E 1247
Score = 109 bits (273), Expect = 2e-23
Identities = 232/1046 (22%), Positives = 371/1046 (35%), Gaps = 166/1046 (15%)
Query: 181 DGGPAPPPAPSSASSSP-----SPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTD 235
DG P P S + SSP S +PS S S P P P R + P
Sbjct: 1429 DGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSEC--DSSPEP 1486
Query: 236 EAYSPPPAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSIS 295
+A P P + P+ ++ TP E E +++
Sbjct: 1487 KALPQTPRPRSR----SPSSPELNNKCLTPQRERSGSESSVDQK---------------- 1526
Query: 296 RISETLAGIYDDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVV 355
++ T G + SQ+ +P A P + + + +P TR R R
Sbjct: 1527 TVARTPLGQRSRSGSSQEL----DVKPSASPQERSESDSSPDSKAKTRTPLRQRSR---S 1579
Query: 356 GTEAEACREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGR 415
G+ E + ++S +G + + +++PR A
Sbjct: 1580 GSSPEVDSKSRLSPRRSRSGSSP-------------------EVKDKPRAA--------- 1611
Query: 416 AARPTPAASATPTAQPLPQPPAPRA-PEGDDFLSLHAESDGEGALQVDLGEPAPAPPAAD 474
P A + + P P+ PAPRA P + S G G P+P +
Sbjct: 1612 -----PRAQSGSDSSPEPKAPAPRALPRRS---RSGSSSKGRG----------PSPEGSS 1653
Query: 475 SRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAK-EAA 533
S + K T RR + SP P + PP R+ SR + + +A+
Sbjct: 1654 STESSPEHPPKSRTARRG--SRSSPEP-----KTKSRTPPRRRSSRSSPELTRKARLSRR 1706
Query: 534 SSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRR 593
S S+ + P + P + +P + SS RRRS S R+++T RR RS +
Sbjct: 1707 SRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPK 1766
Query: 594 RGGSRRSRSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSR-GE 652
G +RSRSR +R + R + + SS S+SRR +++ RSRSR
Sbjct: 1767 PRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRR--------------RQRSRSRSRVTR 1812
Query: 653 KRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLD- 711
+R G + +PA S TS R R R PP+ + + + R
Sbjct: 1813 RRRGGSGYHSRSPARQESSRTS--SRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASP 1870
Query: 712 KSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRK 771
+ R S P S +R S R + RRRS + +S S R SR
Sbjct: 1871 ATHRRSRSRTPLISRRRSRSRTSP--VSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTP 1928
Query: 772 ALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSSSSSCSSRKV 831
+ R R R R R S+ PP S PPV+ S S +S +R+
Sbjct: 1929 PV---TRRRSRSRTPTTRRRSRSRTPPVTRRRSRS--RTPPVT--RRRSRSRTSPITRRR 1981
Query: 832 KLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDERAPTEMAKAA 891
V R S T+P S S V R R P ++ R+ T +
Sbjct: 1982 SRSRTSPVTRRRSRSRTSPVTRRRSRSRTS-PVTRRRSRSRTPPAIRRRSRSRTPLLPRK 2040
Query: 892 PGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKKSKADSCS 951
++ ++ ++ ++ + +GK +++ +R SG S + S
Sbjct: 2041 RSRSR-SPLAIRRRSRSRTPRTARGKRSLTRSPPAIRRRSASGSSSDR-----------S 2088
Query: 952 QAAGTKGAEETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTVDSSCKTPEV------S 1005
++A S S R V + P+++P T C++P + S
Sbjct: 2089 RSATPPATRNHSGS---RTPPVALNSSRMSCFSRPSMSP---TPLDRCRSPGMLEPLGSS 2142
Query: 1006 FLPEEATEEAG---VRGGAEEEEEEEEEEEEEEEEEEQQPATTTATSTAAAAPSTAPSAG 1062
P ++AG + G + + E + + TA S A P + SA
Sbjct: 2143 RTPMSVLQQAGGSMMDGPGPRIPDHQRTSVPENHAQSRIALALTAISLGTARPPPSMSAA 2202
Query: 1063 STAGDSGAEDGPASRVSQLPTLPPPMPWNLPAGVDCTTSGVLALTALLFKMEEANLASRA 1122
G A+R+SQ+P P P+ A S + A +A + A +
Sbjct: 2203 ----------GLAARMSQVPA-PVPLMSLRTAPAANLASRIPAASAAAMNLASARTPAIP 2251
Query: 1123 KAQELIQ-------ATNQILSHRK--PPSSLGMTPAPVPTSLGLP-PGPSSYLLPGSLPL 1172
A L A + S R PS++ + PT+ + G + +L L
Sbjct: 2252 TAVNLADSRTPAAAAAMNLASPRTAVAPSAVNLADPRTPTAPAVNLAGARTPAALAALSL 2311
Query: 1173 GGCGSTPPTPTGLAATSDKREGSSSS 1198
G G TPPT ++S + +S+
Sbjct: 2312 TGSG-TPPTAANYPSSSRTPQAPASA 2336
Score = 87.4 bits (215), Expect = 8e-17
Identities = 165/829 (19%), Positives = 298/829 (35%), Gaps = 131/829 (15%)
Query: 465 EPAPAPPAADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERK 524
+PAP PP S L R+ + R +Q+ + + P R++ + +K
Sbjct: 162 QPAPEPPKPYS------LVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKK 215
Query: 525 RSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPG-----SHASSSARRRSRS--- 576
+ ++ + P P + D K+ RSR P +H S+SA S S
Sbjct: 216 KKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTS 275
Query: 577 RSRSRSTRRRSRST----------DRRRGGSRRSRSREKRRRRRRSASPPPATSSSSSSR 626
RSRSRS ++ +T RRG S +R +SP AT SS
Sbjct: 276 RSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPY 335
Query: 627 RERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAP------------------- 667
++ + K K+K S +RS G E PAP P
Sbjct: 336 EDKDKDK-------KEKSATRPSPSPERSSTGPEP-PAPTPLLAERHGGSPQPLATTPLS 387
Query: 668 -----PPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAP 722
PPS ++ DR + P Q + + V R S P P PAP
Sbjct: 388 QEPVNPPSEASPTRDRSPPKSPEKLP--QSSSSESSPPSPQPTKVSRHASSSPESPKPAP 445
Query: 723 ASSPKREVLYDSEGLSGEERGGKSSQKDR-------RRSGAASSSSSSREKGSRRKALDG 775
A RE+ S + + R +++D+ RR G + S ++++ SR +
Sbjct: 446 APGSHREI---SSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTK 502
Query: 776 GDRDRDRDRDRDRDRSSKK---ARPPKESAPSSGPPPKPPVSSGSGSSSSSSSCSSRKVK 832
R R R RS+++ +R P+ S P +P S + S S+R+ +
Sbjct: 503 RGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQ-RPGWSRSRNTQRRGRSRSARRGR 561
Query: 833 LQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFSRDR-------ESRSPFLKPDERAPT 885
S+ + R S TPA+ S + + SR R SR+P + R+ T
Sbjct: 562 SHSR-SPATRGRSRSRTPARRGRSRSR-TPARRRSRSRTPTRRRSRSRTPARRGRSRSRT 619
Query: 886 EMAKAAPGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKKS 945
A+ + P + + ++++ A+++ ++ +T + R + R+ G S + ++S
Sbjct: 620 P-ARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRS 678
Query: 946 --------------------KADSCSQAAGTKGAEET--------SWSGEERAAKVPSTP 977
+ S S++ +G + S S ER K ++
Sbjct: 679 GRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQ 738
Query: 978 PPKAAPPPPALTPDSQTVDSSCKTPEVSFLPEEATEEAGVR----GGAEEEEEEEEEEEE 1033
+ P + ++ SS ++ +S +A +R G + +++ +
Sbjct: 739 RRSRSNSSPEM---KKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPR 795
Query: 1034 EEEEEEQQPATTTAT----STAAAAPSTAPSAGSTAGDSGAEDGPASRVSQLPTLPPPMP 1089
QP + T S ++++P + + + S + P +V + PP
Sbjct: 796 RSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVK---SGTPPRQ 852
Query: 1090 WNLPAGVDCTTSGVLALTALLFKMEEANLASRAKAQELIQATNQILSHRKPPSSLGMTPA 1149
++ + S + + L SR ++ ++ PP TP
Sbjct: 853 GSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSS-------PPRVKSSTPP 905
Query: 1150 PVPTSLGLPPGPSSYLLPGSLPLGGCGSTPPTPTGLAATSDKREGSSSS 1198
S P P + GS+ P+P+ + + + R S S
Sbjct: 906 RQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVS 954
Score = 67.8 bits (164), Expect = 7e-11
Identities = 61/237 (25%), Positives = 94/237 (39%), Gaps = 19/237 (8%)
Query: 419 PTPAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWG 478
P + P+A QP R S + S + + ++DS
Sbjct: 2510 PASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSS---SSSSSGSSSSDSEGS 2566
Query: 479 GLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAG-PPTRKKSRRERKRSGEAKEAASSSS 537
L ++ ++ +R PSP PAP A G PP ++R+R+ S + ++SSSS
Sbjct: 2567 SLPVQPEVALKR-------VPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSS 2619
Query: 538 GTQPAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTR------RRSRSTD 591
+ + + +S S S S + S A+ ++ + S + RRSRS
Sbjct: 2620 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPR 2679
Query: 592 RRRGGSRRSRSREKR--RRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKR 646
+ R SRS RRR S P P SSSS R RG+ D K++R
Sbjct: 2680 KPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRR 2736
Score = 60.1 bits (144), Expect = 1e-08
Identities = 159/730 (21%), Positives = 249/730 (34%), Gaps = 152/730 (20%)
Query: 374 AGGAAL--PPPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPTPAASATPTAQP 431
AGG+ + P P +P + + + + + R+AL+L ARP P+ SA A
Sbjct: 2152 AGGSMMDGPGPRIP----DHQRTSVPENHAQSRIALALTAISLGTARPPPSMSAAGLAAR 2207
Query: 432 LPQPPAP-------RAPEGDDFLSLHAESDGEGALQVDLGEP-APAPPAADSRWGGLDLR 483
+ Q PAP AP + L + A ++L PA P A ++L
Sbjct: 2208 MSQVPAPVPLMSLRTAPAAN----LASRIPAASAAAMNLASARTPAIPTA------VNLA 2257
Query: 484 RKILTQRRERYRQRSPSPAPAPAPAAAAGP--PTRKKSRRERKRSGEAKEAAS-SSSGTQ 540
SP A AP+ A P PT R+ A A S + SGT
Sbjct: 2258 DSRTPAAAAAMNLASPRTAVAPSAVNLADPRTPTAPAVNLAGARTPAALAALSLTGSGT- 2316
Query: 541 PAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRS 600
PP A+ + S R P + AS++ R + GSR +
Sbjct: 2317 --PPTAAN------YPSSSRTPQAPASANLV----------GPRSAHATAPVNIAGSRTA 2358
Query: 601 RSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSE 660
+ +P + ++ +S R + G S R+RSR + S
Sbjct: 2359 AALAPASLTSARMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPSAPSQSR 2418
Query: 661 KAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSP 720
AP PS S +PP+ + PR P P
Sbjct: 2419 MTSERAPSPSSRMGQAPSQS----LLPPA----------------------QDQPRSPVP 2452
Query: 721 APASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDR 780
+ S R ++ + ++G SQ + A ++SS+ G G
Sbjct: 2453 SAFSDQSRCLIAQTTPVAG-------SQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHS- 2504
Query: 781 DRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSSSSSCSSRKVKLQSKVAVL 840
D +S A+ P SA ++ P K SS S SSSSSSS SS
Sbjct: 2505 ----DVGEPPASTGAQQP--SALAALQPAKERRSSSSSSSSSSSSSSSS----------- 2547
Query: 841 IREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDERAPTEMAKAAPGSTKPKKT 900
SS++ + + S+ S D E S ++P+ K P T K
Sbjct: 2548 -----SSSSSSSSSGSS---------SSDSEGSSLPVQPEVAL-----KRVPSPTPAPKE 2588
Query: 901 KVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKKSKADSCSQAAGTKGAE 960
V+ +G + P+K +++ S S S S S + S S ++ + +
Sbjct: 2589 AVR--------EGRPPEPTPAKRKRRSSSSSSSSSSSSSSS---SSSSSSSSSSSSSSSS 2637
Query: 961 ETSWSGEERAAKVPSTPPPKAAPPP--PALTPDSQTVDSSCKTPEVSFLPEEATEEAGVR 1018
+S S ++ P+ P P+A P P P P + S + P S + + V
Sbjct: 2638 SSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPV- 2696
Query: 1019 GGAEEEEEEEEEEEEEEEEEEQQPATTTATSTAAAAPSTAPSAGSTAGDSGAEDGPASRV 1078
E + +QQ S++ GS G G P+ +
Sbjct: 2697 --------ERRRPSPQPSPRDQQ--------------SSSSERGSRRGQRGDSRSPSHKR 2734
Query: 1079 SQLPTLPPPM 1088
+ P PM
Sbjct: 2735 RRETPSPRPM 2744
Score = 59.7 bits (143), Expect = 2e-08
Identities = 96/405 (23%), Positives = 135/405 (33%), Gaps = 69/405 (17%)
Query: 381 PPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPTPAASATPTAQPLPQPPAPRA 440
PPLL S Q A S P R + P+ S P AQ P+ P P A
Sbjct: 2399 PPLLDRARSRTPPSAPSQSRMTSERAPS---PSSRMGQ-APSQSLLPPAQDQPRSPVPSA 2454
Query: 441 PEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGGLDLRRKILTQRRERYRQRSPS 500
+ + G+ + G A +A G L +
Sbjct: 2455 FSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSV------------------ 2496
Query: 501 PAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDR 560
PAP + PP + + S+ + QPA +S S S
Sbjct: 2497 PAPGVPHSDVGEPP-----------ASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSS 2545
Query: 561 KPGSHASSSARRRSRSRSRSRST--------RRRSRSTDRRRGGSRRSRSRE----KRRR 608
S +SSS+ S S S S +R T + R R E KR+R
Sbjct: 2546 SSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKR 2605
Query: 609 RRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPA-- 666
R S+S ++SSSSSS S S S + G + P PA
Sbjct: 2606 RSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASP 2665
Query: 667 --PPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPAS 724
PPP G+R SR S++D R+++ +++ R PSP P
Sbjct: 2666 KKPPP------GERRSRSPRKPIDSLRD---------SRSLSYSPVER---RRPSPQP-- 2705
Query: 725 SPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSR 769
SP+ + SE S + G S +R S R + SR
Sbjct: 2706 SPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETPSPRPMRHRSSR 2750
Score = 57.0 bits (136), Expect = 1e-07
Identities = 220/1108 (19%), Positives = 363/1108 (32%), Gaps = 186/1108 (16%)
Query: 149 PRLRAWRTGKTVSPQSNSSRPTCARHLTLGTGDGGPAPPP-----APSSASSSPSPSPSS 203
P ++ R S +S R L+L G +P P P S S S P +
Sbjct: 747 PEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKA 806
Query: 204 SSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEAYSPPPAPEQKYDPFEPTGSNPSSSAG 263
S + PP + P P+ P + + SP P + P + + ++P ++
Sbjct: 807 KSRT---PPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQ 863
Query: 264 TPSPEEEE--EEEEEEEEEEEDEEEEEGLSQSISRISETLAGIYDDNSLSQDFPGDESPR 321
+ +P+ E + E + S R+ + P +SP
Sbjct: 864 SVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSST-------------PPRQSPS 910
Query: 322 PDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAEACREGKVSVEVVTAGGAALPP 381
+ P A +P Q + + RV T R + SV + + L P
Sbjct: 911 RSSSPQPKVKAIISPRQRSHSGSSSPSPSRV----TSRTTPRRSR-SVSPCSNVESRLLP 965
Query: 382 PLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPTPAASA-TPTAQPL--PQPPAP 438
G S + V+PE PR + S + P P A TP L + P P
Sbjct: 966 RYSHSGSSSPDTK--VKPETPPRQSHS------GSISPYPKVKAQTPPGPSLSGSKSPCP 1017
Query: 439 RAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGGLDLRRKILTQRRERYRQRS 498
+ D + G+L + G + PP +S +G L+ K +Q +R +
Sbjct: 1018 QEKSKDSLV-----QSCPGSLSLCAGVKSSTPP-GESYFGVSSLQLKGQSQTSPDHRSDT 1071
Query: 499 PSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSR 558
SP E ++S + S S T P
Sbjct: 1072 SSP--------------------EVRQSHSESPSLQSKSQTSP----------------- 1094
Query: 559 DRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPA 618
K G SSS SRS R R ++ + G S E+ R + S+S P
Sbjct: 1095 --KGGRSRSSSPVTELASRSPIRQDRGEFSASPMLKSG----MSPEQSRFQSDSSSYPTV 1148
Query: 619 TSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDR 678
S+S G+ R K PP +T+ R
Sbjct: 1149 DSNS--------------------------LLGQSRLETAESKEKMALPPQEDATASPPR 1182
Query: 679 DSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLS 738
+ P +QD + L K T+ ++ PR S A +S +E S
Sbjct: 1183 QKDKFSPFP--VQDRPESSL-VFKDTL------RTPPRERSGAGSSPETKEQNSALPTSS 1233
Query: 739 GEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDR-----DRDRDRSSK 793
+E + +K +G S SS K + +R D+ + ++S
Sbjct: 1234 QDEELMEVVEKSEEPAGQILSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQASL 1293
Query: 794 KARPPKESAPSSGPPPKPPVSSGSGSS--SSSSSCSSRKVKLQSKVAVLIREGVSSTTPA 851
+A A S G P P +S +S S + + + + G SS
Sbjct: 1294 EAVEVPSMASSWGGPHFSPEHKELSNSPLRENSFGSPLEFRNSGPLGTEMNTGFSSEV-K 1352
Query: 852 KDAASAGLGSIGVKFS---RDRESRSPFLKPDERAPTEMAKAAPGSTKPKKTKV-----K 903
+D L + S +++ +RS E +P + KA S + + V +
Sbjct: 1353 EDLNGPFLNQLETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPR 1412
Query: 904 AKAGAKKTKGTKGKTK---PSKTRKKVRSGGGSGGSGGQVSLKKSKADSCSQAAGTKGAE 960
+ + + + + K P ++ RSG G G S S+ + G K
Sbjct: 1413 TPSRERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDG--SGTPSRHSLSGSSPGMKDIP 1470
Query: 961 ETSWSGEERAAKVPSTPPPKAAPPPP---ALTPDSQTVDSSCKTPEVSFLPEEATEE--- 1014
T G ++ S+P PKA P P + +P S +++ C TP+ E++ +
Sbjct: 1471 RTPSRGR---SECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKT 1527
Query: 1015 -----AGVR---GGAEEEEEEEEEEEEEEEEEEQQPATTTATSTAAAAPSTAPSAGSTAG 1066
G R G ++E + + +E E + P + T T S + S+
Sbjct: 1528 VARTPLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDS 1587
Query: 1067 DS-----GAEDGPASRVSQLPTLPPPMPWNLPAGVDCTTSGVLALTALLFKMEEANLASR 1121
S + G + V P P +G D + L + + +S+
Sbjct: 1588 KSRLSPRRSRSGSSPEVKDKPRAAP----RAQSGSDSSPEPKAPAPRALPRRSRSGSSSK 1643
Query: 1122 AKAQELIQATNQILSHRKPPSS----LGMTPAPVP-TSLGLPPGPSSYLLPGSLPLGGCG 1176
+ +++ S PP S G +P P T PP S
Sbjct: 1644 GRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRS-----------SR 1692
Query: 1177 STPPTPTGLAATSDKREGSSSSEGRGDT 1204
S+P + R SSS E R T
Sbjct: 1693 SSPELTRKARLSRRSRSASSSPETRSRT 1720
Score = 48.1 bits (113), Expect = 5e-05
Identities = 40/147 (27%), Positives = 57/147 (38%), Gaps = 15/147 (10%)
Query: 137 RDPIPLPVPSLLPR-------LRAWRTGKTVSPQSNSSRPTCARHLTLGTGDGGPAPPPA 189
R P P P P R A R ++ S S+SS + + + + + +
Sbjct: 2578 RVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2637
Query: 190 PSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEAYSPPPAPEQKYD 249
SS+SSS S SPS + P P P P +P PP P P D S + Y
Sbjct: 2638 SSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPID---SLRDSRSLSYS 2694
Query: 250 PFEPTGSNPSSSAGTPSPEEEEEEEEE 276
P E +P PSP +++ E
Sbjct: 2695 PVERRRPSPQ-----PSPRDQQSSSSE 2716
Score = 45.1 bits (105), Expect = 5e-04
Identities = 61/312 (19%), Positives = 104/312 (33%), Gaps = 55/312 (17%)
Query: 787 DRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSSSSSCSSRKVKLQSKVAVLIREG-- 844
DR RS P +S +S P P SS G + S S + + +S V +
Sbjct: 2403 DRARSRTPPSAPSQSRMTSERAPSP--SSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSR 2460
Query: 845 --VSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDERAPTEMAKAAPGSTKPKKTKV 902
++ TTP + S G++ S + P P P ST ++
Sbjct: 2461 CLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSA 2520
Query: 903 KAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKKSKADSCSQAAGTKGAEET 962
A +P+K R+ S S S S S + S ++
Sbjct: 2521 LAAL------------QPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSL 2568
Query: 963 SWSGEERAAKVPSTPPPKAAPPPPALTPDSQTVDSSCKTPEVSFLPEEATEEAGVRGGAE 1022
E +VPS P PA P+EA E
Sbjct: 2569 PVQPEVALKRVPS--------PTPA--------------------PKEAVREG------- 2593
Query: 1023 EEEEEEEEEEEEEEEEEQQPATTTATSTAAAAPSTAPSAGSTAGDSGAEDGPASRVSQLP 1082
E + + ++++++S+++++ S++ S+ S++ S + +S S P
Sbjct: 2594 --RPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSP 2651
Query: 1083 TLPPPMPWNLPA 1094
P P PA
Sbjct: 2652 AKPGPQALPKPA 2663
Score = 38.9 bits (89), Expect = 0.033
Identities = 69/347 (19%), Positives = 124/347 (35%), Gaps = 78/347 (22%)
Query: 317 DESPRPDAQPTQPTPAPGTPPQVDSTRADGAM----RRRVFVVGTE----AEACREGKVS 368
+ +P P ++ Q PP D R+ + R + T +++ G V+
Sbjct: 2422 ERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVA 2481
Query: 369 VEVVTAGG----AALPPPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPTPAAS 424
+AG ++P P +P S++ E ++P AL+ +P + ++S
Sbjct: 2482 TTTSSAGDHNGMLSVPAPGVP--HSDVGEPPASTGAQQPS-ALAALQPAKERRSSSSSSS 2538
Query: 425 ATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGA---LQVDLG-----EPAPAPPAADSR 476
++ ++ + + G + SD EG+ +Q ++ P PAP A
Sbjct: 2539 SSSSSSSSSSSSSSSSSSGS------SSSDSEGSSLPVQPEVALKRVPSPTPAPKEA--- 2589
Query: 477 WGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSS 536
+R + R+R S + + + ++++ + S S + ++SSS
Sbjct: 2590 -----VREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2644
Query: 537 SGTQPAP--------PAPASPWDSKKHRSRDRKP-------------------------- 562
S + P+P P PASP R R P
Sbjct: 2645 SSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQ 2704
Query: 563 -------GSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRS 602
S + +RR R SRS S +RR + R R SRS
Sbjct: 2705 PSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETPSPRPMRHRSSRS 2751
Score = 38.1 bits (87), Expect = 0.056
Identities = 30/142 (21%), Positives = 49/142 (34%), Gaps = 8/142 (5%)
Query: 141 PLPVPSLLPRLRAWRTGKTVSPQSNSSRPTCARHLTLGTGDGGPAPPPAPSSASSSPSPS 200
P P P+ R + + + S S+SS + + + + + + SS+ S P
Sbjct: 2596 PEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPG 2655
Query: 201 PSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEAY--------SPPPAPEQKYDPFE 252
P + P PPP +PR I +Y SP P+P +
Sbjct: 2656 PQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSS 2715
Query: 253 PTGSNPSSSAGTPSPEEEEEEE 274
GS + SP + E
Sbjct: 2716 ERGSRRGQRGDSRSPSHKRRRE 2737
Score = 37.4 bits (85), Expect = 0.095
Identities = 75/389 (19%), Positives = 116/389 (29%), Gaps = 88/389 (22%)
Query: 186 PPPAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDE---AYSPPP 242
PP APS + + +PS SS P PPA PR + F A + P
Sbjct: 2410 PPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPV 2469
Query: 243 APEQKYDP-----------------FEPTGSNPSSSAGTPSPEEEEEEEE-----EEEEE 280
A Q P P S G P ++ + +E
Sbjct: 2470 AGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAKE 2529
Query: 281 EEDEEEEEGLSQSISRISETLAGIYDDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVD 340
S S S S + + S S D G P + P+P P+
Sbjct: 2530 RRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPK-- 2587
Query: 341 STRADGAMRRRVFVVGTEAEACREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEIVQPE 400
EA REG+ P P S
Sbjct: 2588 -------------------EAVREGR----------PPEPTPAKRKRRSSSSSSSSSSSS 2618
Query: 401 EEPRLALSLFRPGGRAARPTPAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQ 460
+ S ++ + ++S++ ++ P P P P+A
Sbjct: 2619 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQA-------------------- 2658
Query: 461 VDLGEPA--PAPPAADSRWGGLDLRRKILTQRRERYRQRSP----SPAPAPAPAAAAGPP 514
L +PA PP + R R+ I + R R SP P+P P+P
Sbjct: 2659 --LPKPASPKKPPPGERR--SRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSS 2714
Query: 515 TRKKSRRERKRSGEAKEAASSSSGTQPAP 543
+ + SRR ++ G+++ + P+P
Sbjct: 2715 SERGSRRGQR--GDSRSPSHKRRRETPSP 2741
Score = 35.4 bits (80), Expect = 0.36
Identities = 35/153 (22%), Positives = 47/153 (30%), Gaps = 8/153 (5%)
Query: 184 PAPPPAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEAYSPPPA 243
PA SS+SSS S S SSSS S + + P SP PA
Sbjct: 2526 PAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPA 2585
Query: 244 PEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISETLAG 303
P++ P P+ + + S S S S + +
Sbjct: 2586 PKEAVREGRPPEPTPA--------KRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2637
Query: 304 IYDDNSLSQDFPGDESPRPDAQPTQPTPAPGTP 336
+S S P P P A P +P P
Sbjct: 2638 SSSSSSSSSSSPSPAKPGPQALPKPASPKKPPP 2670
Score = 33.5 bits (75), Expect = 1.4
Identities = 41/189 (21%), Positives = 68/189 (35%), Gaps = 13/189 (6%)
Query: 161 SPQSNSSRPTCARHLTLGTGDGGPAPPPAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAP 220
S S+SS + + G P P SP+P+P + PP P PA
Sbjct: 2546 SSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKR 2605
Query: 221 PAPRFDIYDPFHPTDEAYSPPPAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEE 280
+ + + S + + S+ SSS+ +PSP + + +
Sbjct: 2606 RSSS-SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPAS 2664
Query: 281 EEDEEEEEGLSQSISRISETLAGIYDDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVD 340
+ E S+S + ++L D SLS SP + +P+P P Q
Sbjct: 2665 PKKPPPGERRSRSPRKPIDSLR---DSRSLSY------SP---VERRRPSPQPSPRDQQS 2712
Query: 341 STRADGAMR 349
S+ G+ R
Sbjct: 2713 SSSERGSRR 2721
>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
Length = 904
Score = 126 bits (316), Expect = 2e-28
Identities = 173/701 (24%), Positives = 279/701 (39%), Gaps = 126/701 (17%)
Query: 483 RRKILTQRRERYRQRSPSP-------APAPAPAAAAGPPTRKKSRRERKRSGEAKEAASS 535
RR+ RRER R S SP +P+PAP P + + K +EA S+
Sbjct: 183 RRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPS-VQEATST 241
Query: 536 SSGTQ-------PAPPAPASPWDSKKHRSRDR-KPGSHASSSARRRSRSRSRS-----RS 582
S + P P P+ +SKK + +++ +P S + S +R R+RSRS S R
Sbjct: 242 SDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRR 301
Query: 583 TRRRSRS-TDRRRGGSRRSRSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSK 641
R RSRS + RRR RR S +R RR PP S S RR R G S
Sbjct: 302 HRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSS 361
Query: 642 KKKKRSRS---RGEKRSGDGSEK----APAPAPP-----PSGSTSCGDRDSRRRGAVPPS 689
RSRS + KR+ K +P+ +PP PS + + R + P
Sbjct: 362 SSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPAT---PPPKTRHSPTPQ 418
Query: 690 IQDLTDHDLFAIKRTITVGRLDK--SDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSS 747
+ T ++ T G++ K + SP+PA P++ L +SE G + S
Sbjct: 419 QSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADS 478
Query: 748 QKDRRR-----------SGAASSSSSSREKGSRRKALDGGDRDRD----------RDRDR 786
+ RR+ SG++SSS R K S K + G R R R R +
Sbjct: 479 VQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQK 538
Query: 787 DRDRSSKKARPP------KESAPSSGPPPK---------------PPVSSGSGSSSSSSS 825
+ ++ R P + +PS PPP+ PP S S S
Sbjct: 539 ETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSP 598
Query: 826 CSSRKV-----------------KLQSKVAVLIREGVSSTTPAKDAASA-------GLGS 861
R+ K ++ + + VS + P K +S L S
Sbjct: 599 PIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSS 658
Query: 862 IGVKFSRD----RESRSPFLKPDER-APTEMAKAAPGSTKPKKTKVKAKAGAKKTKGTKG 916
K S RE+RSP +P++R +P+ +A S+ P + A + ++ +
Sbjct: 659 KHRKGSSPSRSTREARSP--QPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSP 716
Query: 917 KTKPSKTRKKVRSGGGSGGSGGQVSLKKSKADSCSQAAGTKGAEETSWSGE-ERAAKVPS 975
T+P + + K KA S S + + + S SG E AAK P
Sbjct: 717 STRPIRRVSRTPE-----------PKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPP 765
Query: 976 TPPPKAAPPPPALTPDSQTVDSSCKTPEVSFLPEEATEEAGVRGGAEEEEEEEEEEEEEE 1035
PP P+ K+P S P +++ G GG +++++++++ ++++
Sbjct: 766 APPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSDQEG--GGKKKKKKKDKKHKKDK 823
Query: 1036 EEEEQQPATTTATSTAAAAPSTAPSAGSTAGDSGAEDGPAS 1076
+ ++ + AAAA + P+A + A + A++ P +
Sbjct: 824 KHKKHKKHKKEKAVAAAAAAAVTPAAIAAATTTLAQEEPVA 864
Score = 108 bits (271), Expect = 3e-23
Identities = 198/872 (22%), Positives = 291/872 (33%), Gaps = 198/872 (22%)
Query: 161 SPQSNSSRPTCARHLTLGTGDGGPAPPPAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAP 220
SP+ SR R + P S S SP S SPSP P P
Sbjct: 171 SPRRRKSRSPSPRRRS------SPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKTPEL- 223
Query: 221 PAPRFDIYDPFHPTDEAYSPP-----PAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEE 275
P P + +P EA S P PE +P E PSPE+ ++E+
Sbjct: 224 PEPSVKVKEP--SVQEATSTSDILKVPKPEPIPEPKE------------PSPEKNSKKEK 269
Query: 276 EEEE-EEEDEEEEEGLSQSISRISETLAGIYDDNSLSQDFPGDESPRPDAQPT--QPTPA 332
E+E+ + S++ SR S S+ + P P +P+ + TP
Sbjct: 270 EKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPP 329
Query: 333 PGTPPQVDSTRADGAMRRRVFVVGTEAEACREGKVSVEVVTAGGAALPPPLLPPGDSEIE 392
PP R+ +RRR + A G S ++ + PP PP +
Sbjct: 330 RRMPPPPRHRRSRSPVRRR-----RRSSASLSGSSS---SSSSSRSRSPPKKPPKRTS-- 379
Query: 393 EGEIVQPEEEPRLALSLFRPGGRAARPTPAASATPTAQPLPQPPAPRAPEGDDFLSLHAE 452
P + R P R RP+P A+ P + P P
Sbjct: 380 -----SPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGR 434
Query: 453 SDGEGALQVDLGEPAPAPPAADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAP----- 507
+ G+ +T+ + ++ SPSPAP P
Sbjct: 435 TSGK------------------------------VTKHKGTEKRESPSPAPKPRKVELSE 464
Query: 508 ---------AAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSR 558
AAA R++ RR+ ++S ++SSS +P K+ +
Sbjct: 465 SEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERP-----------KRSHVK 513
Query: 559 DRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPA 618
+ + G RR S SRS S S R+R + T RG RRS S RRRR + PP
Sbjct: 514 NGEVGRR-----RRHSPSRSASPSPRKRQKETS-PRGRRRRSPSPPPTRRRRSPSPAPPP 567
Query: 619 TSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDR 678
+ + R R + R RS +R ++ +P+PPP T+
Sbjct: 568 RRRRTPTPPPRRR--------TPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPP 619
Query: 679 DSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSP--KREVLYDSEG 736
+RR + P + H P P SSP KR S
Sbjct: 620 PPKRRASPSPPPKRRVSH--------------------SPPPKQRSSPVTKRR----SPS 655
Query: 737 LSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDRSSKKAR 796
LS + R G S + R A S + R S R
Sbjct: 656 LSSKHRKGSSPSRSTRE--ARSPQPNKRHSPSPR-------------------------- 687
Query: 797 PPKESAPSSGPPPKPPVSSGSGSSSSSSSCSSRKVKLQSKV--AVLIREGVSSTTPAKDA 854
P+ SS PPP +S S S S S+R ++ S+ I++ S + +
Sbjct: 688 -PRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRR 746
Query: 855 ASAGLGSIGVKFSRDR---------ESRSPFLKPDERAPTEMAKAAPGSTKPKKTKVKAK 905
S+ G + +S+SP P + AK+ S P + +
Sbjct: 747 VSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSDQEG 806
Query: 906 AGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKKSKADSCSQAAGTKGAEETSWS 965
G KK K K K K KK + KK KA + + AA A +
Sbjct: 807 GGKKKKKKKDKKHKKDKKHKKHKKH------------KKEKAVAAAAAAAVTPAAIAA-- 852
Query: 966 GEERAAKVPSTPPPKAAPPPPALTPDSQTVDS 997
A + P AAP P T +S+ D+
Sbjct: 853 ----ATTTLAQEEPVAAPEPKKET-ESEAEDN 879
Score = 82.0 bits (201), Expect = 3e-15
Identities = 147/715 (20%), Positives = 254/715 (35%), Gaps = 76/715 (10%)
Query: 571 RRRSRSRSRSRSTRRRSRSTDRR----RGGSRRSRSREKRRRRRRSASPPPATSSS---- 622
++R + + S +++ D+R + SR R R + RRR+S SP P SS
Sbjct: 132 KQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRRRSSPVRR 191
Query: 623 ----SSSRRERHRGKHRDGGGSKKKKKRS------------RSRGEKRSGDGSEKAPAPA 666
S SR RHR K R + +KK+++ S E S K P P
Sbjct: 192 ERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPE 251
Query: 667 PPPSGSTSCGDRDSRR---RGAVPPSIQDLTDHDLFAIKRTITVGRLDK---------SD 714
P P +++S++ + P + + R+ + R + S
Sbjct: 252 PIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSP 311
Query: 715 PRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALD 774
R PSP SP+R R +S + RRRS A+ S SSS SR ++
Sbjct: 312 RRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPP 371
Query: 775 GGDRDRDRDRDRDRDRSSKKARPPK---ESAPSSGPPPK------PPVSSGSGSSSSSSS 825
R R R S A PP+ +P + PPPK P S+ + S S S
Sbjct: 372 KKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVS 431
Query: 826 CSSRKVKLQSKVAVLIREGVS-STTPAKDAASAGLGSIGVKFSR--DRESRSPFLKPDER 882
K+ RE S + P K S G K + + R + + +++
Sbjct: 432 PGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQ 491
Query: 883 APTEMAKAAPG-STKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVS 941
+ ++ ++ +PK++ VK ++ + + ++ RK+ + G S
Sbjct: 492 SSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPS 551
Query: 942 LKKSKADSCSQAAGTKGAEETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTVDSSCKT 1001
++ A T R + PS PP + +P P +P Q S
Sbjct: 552 PPPTRRRRSPSPAPPPRRRRTPTPPPRR--RTPSPPPRRRSPSPRRYSPPIQRRYSPSPP 609
Query: 1002 PE--VSFLPEEATEEAGVRGGAEEEEEEEEEEEEEEE--EEEQQPATTTATSTAAAAPST 1057
P+ + P A + ++ + + P+ ++ ++ +
Sbjct: 610 PKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRS 669
Query: 1058 APSAGSTAGDSGAEDGPASRVSQLPTLPPPMPWNLPAGVDCTTSGVLALTAL--LFKMEE 1115
A S + P R Q + PPP+ + S + + + + E
Sbjct: 670 TREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPE 729
Query: 1116 ANLASRAKAQELIQATNQILSHRKPPSSLGMTPAPVPTSLGLPPGPSSYLLPG-----SL 1170
+A A Q+ ++ S R S+ +P P PP P P ++
Sbjct: 730 PKKIKKA-ASPSPQSVRRVSSSR----SVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAV 784
Query: 1171 PLGGCGSTPPTPTGLAATSDKREGSSSSEGRGDTDKYLK-------KLHTQERAV 1218
P+ S PTP+ + +EG + + K+ K K H +E+AV
Sbjct: 785 PVKKAKS--PTPSPSPPRNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAV 837
Score = 61.6 bits (148), Expect = 5e-09
Identities = 130/584 (22%), Positives = 191/584 (32%), Gaps = 133/584 (22%)
Query: 139 PIPLPVPSLLPRLRAWRTGKTVSPQSNSSRPTCARHLTLGTGDGGPAPPPAPSSASSSPS 198
P P S P R R+ ++S S+SS + +R +PP S S S
Sbjct: 334 PPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSAS 393
Query: 199 PSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEAYSPPPAPEQKYDPFEPTGSNP 258
P PSPP PPP + PT + + P +G
Sbjct: 394 PPRRRHRPSPPATPPPKTRHS-------------PTPQQSNRTRKSRVSVSPGRTSG-KV 439
Query: 259 SSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISETLAGIYDDNSLSQDFPGDE 318
+ GT E + + E + EE++G + + + N S G
Sbjct: 440 TKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSS 499
Query: 319 SPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAEACREGKVSVEVVTAGGAA 378
S D +P + S +G + RR + + + K E G
Sbjct: 500 SSSEDERPKR------------SHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRR 547
Query: 379 LPPPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPT-PAASATPTAQPLPQPPA 437
P P R + S P R PT P TP+ P + P+
Sbjct: 548 RSPS---------------PPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPS 592
Query: 438 PR--APEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGGLDLRRKILTQRRERYR 495
PR +P S P+P P +R+ + R
Sbjct: 593 PRRYSPPIQRRYS-----------------PSPPP------------KRRTASPPPPPKR 623
Query: 496 QRSPSPAP------APAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQPAPPAPASP 549
+ SPSP P +P P + P T+ RR S + ++ +S S T+ A SP
Sbjct: 624 RASPSPPPKRRVSHSPPPKQRSSPVTK---RRSPSLSSKHRKGSSPSRSTREA----RSP 676
Query: 550 WDSKKH--RSRDRKPGSH---------ASSSARRRSRSRSRSRSTRRRSRSTDR------ 592
+K+H R R P + ASSS +RR +R RR SR+ +
Sbjct: 677 QPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKA 736
Query: 593 --------RRGGSRRSRSREKRRRRRRSASPPPATSSSSSSRR----------------- 627
RR S RS S ++ +PP S S S
Sbjct: 737 ASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSP 796
Query: 628 ERHRGKHRDGGGSKKKKKRSR-----SRGEKRSGDGSEKAPAPA 666
R ++GGG KKKKK+ + + +K EKA A A
Sbjct: 797 SPPRNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAAA 840
Score = 40.4 bits (93), Expect = 0.011
Identities = 43/185 (23%), Positives = 71/185 (38%), Gaps = 25/185 (13%)
Query: 137 RDPIPLPVPSLLPRLRAWRT---------GKTVSPQSNSSRPTCARHLTLGTGDGGPAPP 187
R P P S PR RA +T G + SPQ S R + + P P
Sbjct: 674 RSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRT--PEPK 731
Query: 188 PAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDI--------YDPFHPTDEAYS 239
+AS SP SS P PA PPAP + + P P +A S
Sbjct: 732 KIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKS 791
Query: 240 PPPAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISE 299
P P+P P S+ +++++ +++++ ++ + ++E + + +
Sbjct: 792 PTPSPS------PPRNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAAAAAAAV 845
Query: 300 TLAGI 304
T A I
Sbjct: 846 TPAAI 850
>gi|117676384 splicing factor, arginine/serine-rich 2, interacting
protein [Homo sapiens]
Length = 1463
Score = 124 bits (311), Expect = 6e-28
Identities = 72/151 (47%), Positives = 93/151 (61%), Gaps = 12/151 (7%)
Query: 1136 SHRKPPSSLGMTPAPV--PTSLGLPPGPSSYLLPGSLPLGGCGSTPPTPTGLAATS-DKR 1192
SH S + PAP P + G+ GPSS G S+ + AA +
Sbjct: 1308 SHVSNNMSTPVLPAPTAAPGNTGMVQGPSS---------GNTSSSSHSKASNAAVKLAES 1358
Query: 1193 EGSSSSEGRGDTDKYLKKLHTQERAVEEVKLAIKPYYQKKDITKEEYKDILRKAVHKICH 1252
+ S + E D+ K KKL QE+A +EVKLAIKP+YQ KDITKEEYK+I+RKAV K+CH
Sbjct: 1359 KVSVAVEASADSSKTDKKLQIQEKAAQEVKLAIKPFYQNKDITKEEYKEIVRKAVDKVCH 1418
Query: 1253 SKSGEINPVKVSNLVRAYVQRYRYFRKHGRK 1283
SKSGE+N KV+NLV+AYV +Y+Y RK +K
Sbjct: 1419 SKSGEVNSTKVANLVKAYVDKYKYSRKGSQK 1449
Score = 60.1 bits (144), Expect = 1e-08
Identities = 60/193 (31%), Positives = 87/193 (45%), Gaps = 21/193 (10%)
Query: 490 RRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQPAPPAPASP 549
R R R SPS +P P +K+ + R KE+ S S P+P +
Sbjct: 788 RTRRSRFHSPSTTWSPNKDT---PQEKKRPQSPSPRRETGKESRKSQS------PSPKNE 838
Query: 550 WDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRR 609
+ +SR + P + RR+S+SRS R T R SR ++ RR SRE +R +
Sbjct: 839 SARGRKKSRSQSPKKDIARE-RRQSQSRSPKRDTTRESRRSESL--SPRRETSRENKRSQ 895
Query: 610 RRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPP 669
R P S S S R R RDG +++++ R+R RS S ++P+
Sbjct: 896 PRVKDSSPGEKSRSQS---RERESDRDG---QRRERERRTRKWSRSRSHS-RSPSRCRTK 948
Query: 670 SGSTSCG--DRDS 680
S S+S G DRDS
Sbjct: 949 SKSSSFGRIDRDS 961
Score = 45.4 bits (106), Expect = 3e-04
Identities = 96/436 (22%), Positives = 150/436 (34%), Gaps = 94/436 (21%)
Query: 384 LPPGDSEIEEGEIV-QPEEEPRLALSLFR-PGGRAAR---PTPAASA---TPTAQPLPQP 435
+P D E+ E V QP E P+ + + P R +R P+ S TP + PQ
Sbjct: 757 MPSSDLADEKVETVSQPSESPKDTIDKTKKPRTRRSRFHSPSTTWSPNKDTPQEKKRPQS 816
Query: 436 PAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGGLDLRRKILTQRRERYR 495
P+PR G +E +
Sbjct: 817 PSPRRETG-----------------------------------------------KESRK 829
Query: 496 QRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQPAPPAPASPWDSKKH 555
+SPSP A RKKSR + + A+E S S +P +
Sbjct: 830 SQSPSPKNESARG-------RKKSRSQSPKKDIARERRQSQS------RSPKRDTTRESR 876
Query: 556 RSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASP 615
RS P +S +RS+ R + S +SRS R R R + RE+ RR R+ +
Sbjct: 877 RSESLSP-RRETSRENKRSQPRVKDSSPGEKSRSQSRERESDRDGQRRERERRTRKWSR- 934
Query: 616 PPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGE-----KRSGDGSEKAPAPAPPPS 670
+ S S S R R + K G + R +G R G+++ P
Sbjct: 935 --SRSHSRSPSRCRTKSKSSSFGRIDRDSYSPRWKGRWANDGWRCPRGNDRYRKNDPEKQ 992
Query: 671 GSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKREV 730
+ +++ A P+ D +D IT DPR +P E
Sbjct: 993 NENTRKEKNDIHLDADDPNSADKHRND---CPNWITEKINSGPDPRTRNPEKLKESHWE- 1048
Query: 731 LYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDR 790
E R S + G+ S+ R +G+R + G R +D++ +R
Sbjct: 1049 ---------ENRNENSGNSWNKNFGSGWVSNRGRGRGNRGR---GTYRSSFAYKDQNENR 1096
Query: 791 SSKKARPPKESAPSSG 806
+ +P ++ SSG
Sbjct: 1097 WQNR-KPLSGNSNSSG 1111
Score = 37.4 bits (85), Expect = 0.095
Identities = 45/217 (20%), Positives = 78/217 (35%), Gaps = 46/217 (21%)
Query: 603 REKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKA 662
+ K+ R RRS P+T+ S + + ++KKR +S +R G E
Sbjct: 783 KTKKPRTRRSRFHSPSTTWSPNK-------------DTPQEKKRPQSPSPRRE-TGKESR 828
Query: 663 PAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAP 722
+ +P P ++ G + SR + K R +
Sbjct: 829 KSQSPSPKNESARGRKKSRSQSP-------------------------KKDIARERRQSQ 863
Query: 723 ASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDRDR 782
+ SPKR+ +S ++S++++R SS + S+ R+R+
Sbjct: 864 SRSPKRDTTRESRRSESLSPRRETSRENKRSQPRVKDSSPGEKSRSQ-------SRERES 916
Query: 783 DRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSGS 819
DRD R ++ R S S P + S S S
Sbjct: 917 DRDGQRRERERRTRKWSRSRSHSRSPSRCRTKSKSSS 953
Score = 30.8 bits (68), Expect = 8.9
Identities = 38/144 (26%), Positives = 64/144 (44%), Gaps = 14/144 (9%)
Query: 797 PPKESAPSSGPPPKPPVSSGSGSSSSSSSCSSRKVKL-QSKVAVLIREGVSSTTPAKDAA 855
P +AP + + P SSG+ SSSS S S+ VKL +SKV+V + S+ K
Sbjct: 1320 PAPTAAPGNTGMVQGP-SSGNTSSSSHSKASNAAVKLAESKVSVAVEASADSSKTDKKLQ 1378
Query: 856 SAGLGSIGVK-----FSRDRE-SRSPFLKPDERAPTEMAKAAPGSTKPKKTKVKAKAGAK 909
+ VK F ++++ ++ + + +A ++ + G K KA
Sbjct: 1379 IQEKAAQEVKLAIKPFYQNKDITKEEYKEIVRKAVDKVCHSKSGEVNSTKVANLVKAYVD 1438
Query: 910 K----TKGTKGKT--KPSKTRKKV 927
K KG++ KT +P T K +
Sbjct: 1439 KYKYSRKGSQKKTLEEPVSTEKNI 1462
>gi|163965366 nascent polypeptide-associated complex alpha subunit
isoform a [Homo sapiens]
Length = 2078
Score = 103 bits (257), Expect = 1e-21
Identities = 246/1194 (20%), Positives = 379/1194 (31%), Gaps = 205/1194 (17%)
Query: 139 PIPLPVPSLLPRLRAWRTGKTVSPQSNSSRPTCARHLTLGTGDGGPAPPPAPSSASSSPS 198
P P V L P+ G T+ P+ + P+ G PAP AP+ + +S S
Sbjct: 865 PTPSAVTPLSPK------GVTLPPKETPT-PSVVNLPFPKEGPATPAPKQAPALSMTSSS 917
Query: 199 PSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEAYSPPPAPEQKYDPFEPTGSNP 258
P + ++P+P P P+P P P P P P K+ P P + P
Sbjct: 918 PKKARATPAPKGIPASPSPKGAPTP------PAATPPSPKGGPATPSPKWAPTPPAATPP 971
Query: 259 SSSAG--TPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISETLAGIYDDNSLSQDFPG 316
S G TPSP+ P
Sbjct: 972 SPKGGPATPSPKGAPTP-----------------------------------------PA 990
Query: 317 DESPRPDAQPTQPTP--APGTPPQVDSTRADGAMRRRVFVVGTEAEACREGKVSVEVVTA 374
P P P P+P AP TPP V G+ F G T
Sbjct: 991 ATPPSPKGGPATPSPKGAP-TPPAVTPPSPKGSPAATPFPKGAS--------------TP 1035
Query: 375 GGAALPPPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPTPAASATPTAQPLPQ 434
A P P P + + +G P A +L P G A P+ + TP A P
Sbjct: 1036 PAATPPSPKGSPAATPLPKGAPTTP------AATLPSPKGGPATPSLKGAPTPPAATPPS 1089
Query: 435 P---PAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAA--DSRWGGLDLRRKILTQ 489
P PA +P+G +G L + AP PAA S GG L
Sbjct: 1090 PKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGG-------LAT 1142
Query: 490 RRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQPAPPAPASP 549
+ +P+ P P+P P K + + + + ++ + AP PA+
Sbjct: 1143 PPPKGAPTTPAATP-PSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAAT 1201
Query: 550 WDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRR 609
S K G A+ S + + + + + + +T +G + +
Sbjct: 1202 PPSPK--------GGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKG 1253
Query: 610 RRSASPP-----PATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPA 664
+ PP P ++ S + H+ S G S P
Sbjct: 1254 GPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPP 1313
Query: 665 PAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITV---GRLDKSDPRGPSPA 721
A PPS S G + PP++ + + T G S GP+P
Sbjct: 1314 AATPPSPKGSPG-TPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTP- 1371
Query: 722 PASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSS------------SSREKGSR 769
PA++P +GG + + G A S S ++ +
Sbjct: 1372 PAATP-------------SHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPAT 1418
Query: 770 RKALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSSSSSCSSR 829
+G D + P SAP G P P S G + + + S +
Sbjct: 1419 PVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGG--PATPSSKGDPTLPAVTPPSPK 1476
Query: 830 KVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDERAPTE--M 887
+ +VA + TPA A L ++ + S +P + D APT +
Sbjct: 1477 EPPAPKQVATSSSPKKAPATPAPMGAPT-LPAV-IPSSPKEVPATPSSRRDPIAPTATLL 1534
Query: 888 AKAAPGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSG-------GQV 940
+K P + PK+ + K T P + S S G
Sbjct: 1535 SKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAP 1594
Query: 941 SLKKSKADSCSQAAGTKGAEETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTVDSSCK 1000
S K+ + K A K P+TP PK P P +TP S + S
Sbjct: 1595 SPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSS--LKDSPT 1652
Query: 1001 TPEVSFLPEEATEEAGVRGGAEEEEEEEEEEEEEEEEEEQQPATTTAT-------STAAA 1053
+P AT +G ++ +E E P T T ++A
Sbjct: 1653 SPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSAT 1712
Query: 1054 APSTAPSAGSTAGDSGAEDGPASRVSQLPTLPPPMPWNLPA-GVDCTTSGVLALTALLFK 1112
+P P + G GP S V+ P LP + A G D + S L K
Sbjct: 1713 SPPICPDPSAKNGSK----GPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESK 1768
Query: 1113 MEEANLASRAKAQELIQATNQILSHRKPPSSLGMTPAPVPTSLGLPP------------- 1159
A+ + + + + PP SL + P+PVPT LPP
Sbjct: 1769 ASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPT---LPPKQQFLPSSPGLVL 1825
Query: 1160 -GPSSYLLPGS----LPL-------GG---------------CGSTPPTPTGLAATSDKR 1192
PS L P LPL GG G PTP+ +
Sbjct: 1826 ESPSKPLAPADEDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNN 1885
Query: 1193 EGSSSSEGRGDTDKYLKKLHTQERAVEEVKLAIKPYYQKKDITKEEYKDILRKA 1246
+GS + ++ L++ + + ++ +LA ++ ++K + +KA
Sbjct: 1886 KGSGTESDSDESVPELEEQDSTQATTQQAQLAAAAEIDEEPVSKAKQSRSEKKA 1939
Score = 55.8 bits (133), Expect = 3e-07
Identities = 94/404 (23%), Positives = 134/404 (33%), Gaps = 39/404 (9%)
Query: 802 APSSGPPPKPPVSSGSGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGS 861
AP + P + P SG+S+++SS + S + + + P SAG +
Sbjct: 761 APVASSPKECPTED-SGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDT 819
Query: 862 -IGVKFSRDRESRSPFLKPDERAPTEMAKAAPGSTK---PKKTKVKAKAGAKKTKGTKGK 917
IG S + FL P+ + +K +P +T P K A KG
Sbjct: 820 PIGNLSSPVSPVEASFL-PENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGV 878
Query: 918 TKPSKTRKKVRSGGGSGGSGGQVSLKKSKADSCSQAAGTKGAEETSWSGEERAAK----- 972
T P K + V+L K + A A + S ++A
Sbjct: 879 TLPPKETP----------TPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPK 928
Query: 973 -VPSTPPPKAAPPPPALTPDSQTVDSSCKTPEVSFLPEEATEEAGVRGGAEEEEEEEEEE 1031
+P++P PK AP PPA TP S + +P+ + P AT + G A +
Sbjct: 929 GIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTP 988
Query: 1032 EEEEEEEEQQPATTTATSTAAAAPSTAPSAGSTAGDSGAEDGPASRVSQLPTLPPPMPWN 1091
+ T + A P+ P S G A P S P PP P
Sbjct: 989 PAATPPSPKGGPATPSPKGAPTPPAVTPP--SPKGSPAATPFPKG-ASTPPAATPPSPKG 1045
Query: 1092 LPAGVDCTTSGVLALTALLFKMEEANLASRAKAQELIQATNQILSHRKPPSSLGMTPAPV 1151
PA A L + K A PPS G P
Sbjct: 1046 SPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAAT-------PPSPKGGPATPS 1098
Query: 1152 PTSLGLPPGPSSYLLPGSL---PLGGC----GSTPPTPTGLAAT 1188
P +PP + G L P G +TPP+P G AT
Sbjct: 1099 PKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLAT 1142
Score = 55.1 bits (131), Expect = 4e-07
Identities = 267/1331 (20%), Positives = 392/1331 (29%), Gaps = 234/1331 (17%)
Query: 73 SEPRSQESGGTDTATVLDMATDSFLAGLVSVLDPPDTWVPSRLDLRP-GESEDMLELVAE 131
+ P + + T T V + +G +S ++P P+ L + P E ++
Sbjct: 444 TNPCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTS---PAALVMAPVAPKEPSTQVATT 500
Query: 132 VRIGDRDPIPLPVP------SLLPRLRAWRTGKTVSPQSNSSRPTCARHLTLGTGDGGPA 185
+RI P+P P S+L + + +TV P S P L T
Sbjct: 501 LRIPVSPPLPDPEDLKNLPSSVLVKFPTQKDLQTV-PASLEGAPFSPAQAGLTTKKDPTV 559
Query: 186 PPPAPSSASSSPSPSPSSSSPSPPPPPPP---------PAPPAPPAPRFDI--------- 227
P ++ +SPS +SSSP P P P P PA
Sbjct: 560 LPLVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSAS 619
Query: 228 ---YDPFHPTDEA-------YSPPPAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEE--EE 275
D + D A P + +P G P+++ GT + E
Sbjct: 620 VIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKGTSTYTTTASPFLEG 679
Query: 276 EEEEEEEDEEEEEGLSQSISRISETLAGIYDDNSLSQDFPGDESPR-------------- 321
++ +EG ++ + + S++ P SP+
Sbjct: 680 TVSLAPKNHPVKEGTLTTLPLVP----------TASENCPVAPSPQNTCAPLATLVLAPE 729
Query: 322 -PDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVV-------------GTEAEACREGKV 367
P + P+ P GTPP + + DG G A A +G +
Sbjct: 730 IPKSVPSPSLPPAGTPP--GTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTL 787
Query: 368 S--VEVVTAGGAALPPPLLPPGDSEIEEG---------EIVQPEEEPRLALSLFRPGGRA 416
+ + + G ++ P P + G V P E L + G
Sbjct: 788 TYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSK 847
Query: 417 ARPTPAASATPTAQ---PLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPA-PAPPA 472
P S TP + P P P +P+G + L PA PAP
Sbjct: 848 DSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQ 907
Query: 473 ADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEA 532
A + +K + SPSP AP P AA PP+ K
Sbjct: 908 APALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAAT-PPSPKGG------------P 954
Query: 533 ASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDR 592
A+ S P PPA P G A+ S + + + + + +T
Sbjct: 955 ATPSPKWAPTPPAATPP----------SPKGGPATPSPKGAPTPPAATPPSPKGGPATPS 1004
Query: 593 RRGGSRRSRSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGE 652
+G A PPA + S G + + S
Sbjct: 1005 PKG-----------------APTPPAVTPPSPK-----------GSPAATPFPKGASTPP 1036
Query: 653 KRSGDGSEKAPAPAPPPSGS--TSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRL 710
+ + +PA P P G+ T S + G PS++ A
Sbjct: 1037 AATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKG-------APTPPAATPPS 1089
Query: 711 DKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRR 770
K P PSP A P +GG ++ + +++ S + G
Sbjct: 1090 PKGGPATPSPKGAPMPPAAT-------PPSPKGGLATPPHKGAPTTPAATPPSPKGGLAT 1142
Query: 771 KALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPPK-PPVSSGSGSSSSSSSCSSR 829
G ++ A PP + PPPK P + + S ++
Sbjct: 1143 PPPKGAP-------------TTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATP 1189
Query: 830 KVKLQSKVAVLIREGVSSTTPAKDAAS--AGLGSIGVKFSRDRESRSPFLKPDERAPTEM 887
K + TTPA S GL + K + + +P P T
Sbjct: 1190 SPK------------GAPTTPAATPPSPKGGLATPSPKGAPTTPAATP-PSPKGGLATPS 1236
Query: 888 AKAAPGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKKSKA 947
K AP T P T K G T P+ T ++ G + G +
Sbjct: 1237 PKGAP--TTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTP 1294
Query: 948 DSCSQAAGT---KGAEETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTVDSSCKTPEV 1004
S T KGA + P TPPPK AP PPA+TP S TP +
Sbjct: 1295 PSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPK-----GTPTL 1349
Query: 1005 SFLPEEATEEAGVRGGAEEEEEEEEEEEEEEEEEEQQPATTTATSTAAAAPSTAPSAGST 1064
AT + G +E + PA T + P P+ S
Sbjct: 1350 P-----ATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPS------PKRGPAIPSP 1398
Query: 1065 AGDSGAEDGPASRVSQLPTLPPPMPWNLPAGVDCTTSGVLALTALLFKMEEANLASRAKA 1124
GD P S P + P P PA T G + S KA
Sbjct: 1399 KGD------PTS-----PAVIPLSPKKAPA-TPVTREGAATPSKGDLTPPAVTPVSLKKA 1446
Query: 1125 QELIQATNQILSHRKPPSSLG--MTPAPVPTSLGLPPGPSSYLL---PGSLPLGGCGSTP 1179
AT+ PSS G PA P S PP P P P
Sbjct: 1447 P----ATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGA 1502
Query: 1180 PTPTGLAATSDKREGSSSSEGRGDTDKYLKKLHTQERAVEEVKLAIKPYYQKKDITKEEY 1239
PT + +S K ++ S R L + A K A+ P K+
Sbjct: 1503 PTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTP 1562
Query: 1240 KDILRKAVHKICHSKSGEINPVKVSNLVRAYVQRYRYFRKHGRKPGDPPGPPRPPKEPGP 1299
K SK P + + P P PP P
Sbjct: 1563 AIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPP 1622
Query: 1300 PDKGGPGLPLP 1310
+ GP P P
Sbjct: 1623 SPEKGPATPAP 1633
Score = 49.3 bits (116), Expect = 2e-05
Identities = 97/428 (22%), Positives = 144/428 (33%), Gaps = 51/428 (11%)
Query: 199 PSPSSSSPSPPPP-PPPPAPPAPPAPRFDIYDPFHPTDEAYSPPPAPEQKYDPFEPTGSN 257
P+ + SP P P P PA P+ + + P T Y P+P++ P T +
Sbjct: 1551 PAMTVPSPKKTPAIPTPKEAPATPSSK-EASSPPAVTPSTYKGAPSPKELLIPPAVTSPS 1609
Query: 258 PSS-----SAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQS-ISRISETLAGIYDDNSLS 311
P + PSPE+ + L S S S T S
Sbjct: 1610 PKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQAS 1669
Query: 312 QDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAEACREGKVSVEV 371
+ P + P + PAP + P + + G ++ T C +
Sbjct: 1670 KGLPAKKGPTA-LKEVLVAPAPESTPIITAPTRKGPQTKK--SSATSPPICPDPSAKNGS 1726
Query: 372 VTAGGAALPPPLLP-----------PGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARP- 419
P PLLP S +G + PE + L+ +P
Sbjct: 1727 KGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPE 1786
Query: 420 ---TPAASATPTAQPLPQPPAPRAPEGDDFL----SLHAESDGEGALQVDLGEPAP-APP 471
AA + P + PL P P P FL L ES + D E P PP
Sbjct: 1787 SASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPP 1846
Query: 472 AADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSG---- 527
S GG+ + ++ +P A P P +A P K ++ S
Sbjct: 1847 EPIS--GGVPFQSVLV-------NMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDES 1897
Query: 528 --EAKEAASSSSGTQPAPPAPASPWD----SKKHRSRDRKPGSHASSSARRRSRSRSRSR 581
E +E S+ + TQ A A A+ D SK +SR K A S R + +R
Sbjct: 1898 VPELEEQDSTQATTQQAQLAAAAEIDEEPVSKAKQSRSEKKARKAMSKLGLR-QVTGVTR 1956
Query: 582 STRRRSRS 589
T R+S++
Sbjct: 1957 VTIRKSKN 1964
Score = 33.1 bits (74), Expect = 1.8
Identities = 35/93 (37%), Positives = 40/93 (43%), Gaps = 22/93 (23%)
Query: 184 PAPPPAPSSAS--SSPSPSPSSSSPSPPPPPPP--------PAPPAPPAPRF---DIYDP 230
PAP P SA+ +SP PSPS+ + +P P P P AP AP F I P
Sbjct: 51 PAPQQCPLSAANQASPFPSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPP 110
Query: 231 FHPTDEAY-SPPPAPEQKYDPFEPTGSNPSSSA 262
P A SP AP K PSSSA
Sbjct: 111 ISPAALALASPMIAPTLK--------GTPSSSA 135
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 97.4 bits (241), Expect = 8e-20
Identities = 210/1050 (20%), Positives = 334/1050 (31%), Gaps = 142/1050 (13%)
Query: 250 PFEPTGSNPSSSAGTPSPEEEEEEEEE----EEEEEEDEEEEEGLSQSISRISETLAGIY 305
P TG ++ SP + E E EEE G + +S A
Sbjct: 140 PHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSS 199
Query: 306 DDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAEACREG 365
+++ S D +P +P Q + + + + +A A G
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPA----------------PG 243
Query: 366 KVSVEVVTAGGAALPPPLL---PPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPTPA 422
KV G ALPP P +SE E EE P S + + + A
Sbjct: 244 KVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAA 303
Query: 423 ---ASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGG 479
A TP P PP + E D E + + + + PAA +
Sbjct: 304 SAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSE-ESSDSEEETPAAKALLQA 362
Query: 480 LDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGT 539
+ + SP APAP GP K +R+ ++ S S
Sbjct: 363 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEE 422
Query: 540 QPAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRR 599
PA P+ + S K ++ ++ + + + D R
Sbjct: 423 APAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEES 482
Query: 600 SRSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGS 659
RE + P S G G G K + + G
Sbjct: 483 DSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWE 542
Query: 660 EKAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPS 719
E + + + S S+ G VP ++ + L I + K P+
Sbjct: 543 EDSESSSEESSDSSD---------GEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAG 593
Query: 720 PAPASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSRE--KGSRRKALDGGD 777
P + + +SE S EE S D + AA +++ ++ K + KA
Sbjct: 594 PVAVQVKAEKPMDNSE--SSEE---SSDSADSEEAPAAMTAAQAKPALKIPQTKACP--- 645
Query: 778 RDRDRDRDRDRDRSSKKARP-------PKESAPSSGPPPKPPVSSG-----SGSSSSSSS 825
+ +S K P P+++ ++ P P +G + SSSS
Sbjct: 646 -------KKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEE 698
Query: 826 CSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIG-----------------VKFSR 868
S + K V V + V K A+ GS+G VK +
Sbjct: 699 SDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEK 758
Query: 869 DRESRSPFLKPDERAPTEMAKAAPGSTKP--KKTKVKAKAGAKKTKGTKG---------- 916
+S S +E + +E A A+P K KKT+ KA A + KG
Sbjct: 759 QEDSES----SEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVT 814
Query: 917 ------KTKPSKTRKKVRSGGGS----GGSGGQVSLKKSKADSCSQAAGTK----GAEET 962
+ PSK + VR+ S G S+ K+ A + G + +EE
Sbjct: 815 AAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEE 874
Query: 963 SWSGEERAAKVPSTPPPKAAPPPPALTPDSQTV-DSSCKTPEVSFLPEEATEEAGVRGGA 1021
S S EE P K AL P ++ + TP P A +AG + +
Sbjct: 875 SDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAA--QAGKQDDS 932
Query: 1022 EEEEEEEEEEEE------------------EEEEEEQQPATTTATSTAAAAPSTAPSAGS 1063
EE + + E + PA T A + AA+ P A ++ S
Sbjct: 933 GSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASES 992
Query: 1064 TAGDSGAEDGPASRVSQLPTLPPPMPWNLPAGVDCTTSGVLALTALLFKMEEANLASRAK 1123
TA S +E + L P + N+ + A + K A +S +
Sbjct: 993 TARSSSSESEDEDVIPATQCLTPGIRTNV-------VTMPTAHPRIAPKASMAGASSSKE 1045
Query: 1124 AQELIQATNQILSHRKPPSSLGMTPAPVPTSLGLPPGPSSYLLPGSLPLGGCGSTPPTPT 1183
+ + Q + S++G PA P S + ++ L LP P
Sbjct: 1046 SSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLP--EVQQATKAPE 1103
Query: 1184 GLAATSDKREGSSSSEGRGDTDKYLKKLHT 1213
+ D + SS SE G+ + K HT
Sbjct: 1104 SSDDSEDSSDSSSGSEEDGEGPQGAKSAHT 1133
Score = 82.0 bits (201), Expect = 3e-15
Identities = 197/920 (21%), Positives = 313/920 (34%), Gaps = 178/920 (19%)
Query: 185 APPPAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEAYSPPP-- 242
A P +S SS S + S +P A PA P+ T + P
Sbjct: 601 AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR 660
Query: 243 ----APEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRIS 298
AP + P GS+P+ + GT P E+ EE + EEE+ GL+ ++ +
Sbjct: 661 VGTQAPRKAGTATSPAGSSPAVAGGTQRP----AEDSSSSEESDSEEEKTGLAVTVGQAK 716
Query: 299 ETLAGIY-------------------------------------DDNSLSQDFPGDESPR 321
G+ D S ++ +E+
Sbjct: 717 SVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAA 776
Query: 322 PDAQ---PTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAEACREGKVSVE-------- 370
AQ + T A P + A G + VV A+A + V+
Sbjct: 777 SPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQN 836
Query: 371 --VVTAGGAALP-----------PPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRA- 416
V+ G A++P P DS E E EE L+ +P G+
Sbjct: 837 STVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEE--SDSEEEAETLAQVKPSGKTH 894
Query: 417 --------ARPTPAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAP 468
A+ +P A PT P A +A + DD S ESD +G
Sbjct: 895 QIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDG----------E 944
Query: 469 APPAADSRWGGLDLRRKILTQRRERYRQRSPS-PAPAPAPAAAAGPPTRKKSRRERKRSG 527
AP A S + I RSP+ PA PA A AA P RK
Sbjct: 945 APAAVTS-------AQVIKPPLIFVDPNRSPAGPAATPAQAQAASTP--------RKARA 989
Query: 528 EAKEAASSSSGTQPAPPAPASPWDSKKHRSR-DRKPGSHASSSARRRSRSRSRSRSTRRR 586
A SSSS ++ PA+ + R+ P +H + + S S+ + R
Sbjct: 990 SESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRI 1049
Query: 587 SRSTDRRRGGSRRSRSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRD------GGGS 640
S ++ G + + S + PATS S+S + + K R +
Sbjct: 1050 S-DGKKQEGPATQVDS---------AVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQAT 1099
Query: 641 KKKKKRSRSRGEKRSGDGSEK-APAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLF 699
K + S S GSE+ P S T G SR V + + ++ D+
Sbjct: 1100 KAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVV 1159
Query: 700 AIKRTITVGRLDKSDPRGPSPAPASSPKRE--VLYDSEGLSGEERGGKSSQKDRRRSGAA 757
A +++ G + S A ++PK + S + ++ GK K ++ +G
Sbjct: 1160 APSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGML 1219
Query: 758 SSSSSSREKGSRRKALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGS 817
S + +E S + +K+R PK+ A G P ++ S
Sbjct: 1220 SPKTGGKEAAS--------------------GTTPQKSRKPKKGA---GNPQASTLALQS 1256
Query: 818 GSSS---------SSSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFSR 868
+ + + + VK+ +++ R+ V TT K+++ G S K S
Sbjct: 1257 NITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTT--KESSRKGWESRKRKLSG 1314
Query: 869 DR-ESRSPFLKPDERAPTEMAKAAPGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKV 927
D+ +R+P K ++ + S P+KT +K AK+ K + G K K + +
Sbjct: 1315 DQPAARTPRSKKKKKLGA--GEGGEASVSPEKTSTTSKGKAKRDKAS-GDVKEKKGKGSL 1371
Query: 928 RSGG-----------GSGG-SGGQVSLKKSKADSCSQAAGTKGAEETSWSGEERAAKVPS 975
S G G G GG S KSK + K E+ + + A
Sbjct: 1372 GSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKD 1431
Query: 976 TPPPKAAPPPPALTPDSQTV 995
+ P QTV
Sbjct: 1432 SESPSQKKKKKKKKTAEQTV 1451
Score = 74.3 bits (181), Expect = 7e-13
Identities = 176/937 (18%), Positives = 297/937 (31%), Gaps = 126/937 (13%)
Query: 184 PAPP-PAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEA-YSPP 241
PAPP A + AS + + P S S P A T + +
Sbjct: 317 PAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 376
Query: 242 PAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISETL 301
PA E P + A + + EE+ + EE D EEE S + +
Sbjct: 377 PAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQV 436
Query: 302 AGIYDDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAEA 361
+ P ESPR A P P QV + + R +
Sbjct: 437 R--------AASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSR----------SS 478
Query: 362 CREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPTP 421
E E + A AA PL G S P+ +P + + P G+ A P P
Sbjct: 479 SEESDSDREALAAMNAAQVKPL---GKS---------PQVKPASTMGM-GPLGKGAGPVP 525
Query: 422 AASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGGLD 481
P P + E + S + +G + P PA + G +
Sbjct: 526 PGKVGPAT---PSAQVGKWEEDSESSSEESSDSSDGEV------PTAVAPAQEKSLGNI- 575
Query: 482 LRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQP 541
Q P+ +PA P AGP + + + E+ E +S S+ ++
Sbjct: 576 -------------LQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEE 622
Query: 542 APPA---------------PASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRR 586
AP A A P + S P + + R+ + S + S+
Sbjct: 623 APAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAV 682
Query: 587 SRSTDRRRGGSRRSRSREKRRRR-----------------RRSASPPPATSSSSSSRRER 629
+ T R S S + + + A+ P S
Sbjct: 683 AGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPV 742
Query: 630 HRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPS 689
GK K +K+ S + D E A +PA + S + A PS
Sbjct: 743 LPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKT-SVKKTQAKANPAAARAPS 801
Query: 690 IQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQK 749
+ + A + +T K P +P+ + S G +
Sbjct: 802 AKG----TISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATA 857
Query: 750 DRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPP 809
+ ++G S SS E+ + + + + + + A P + +P G P
Sbjct: 858 AQAQTGPEEDSGSSEEESDSEEEAE----TLAQVKPSGKTHQIRAALAPAKESPRKGAAP 913
Query: 810 KPPVSSGSGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFSRD 869
PP +G ++ + S G SS +++ S G V ++
Sbjct: 914 TPPGKTGPSAAQAGKQDDS---------------GSSS----EESDSDGEAPAAVTSAQV 954
Query: 870 RESRSPFLKPDERAPTEMAKAAPGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRS 929
+ F+ P+ R+P A A P + T KA+A + + +++ +
Sbjct: 955 IKPPLIFVDPN-RSPAGPA-ATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQC 1012
Query: 930 -GGGSGGSGGQVSLKKSKADSCSQAAGTKGAEETSWSGEERAAKVPSTPPPKAAPPPPAL 988
G + + + + AG ++E+S + + + P+T A PA
Sbjct: 1013 LTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPAT 1072
Query: 989 TPDSQTVD----SSCKTPEVSFLPEEATEEAGVRGGAEEEEEEEEEEEEEEEEEEQQPAT 1044
+P S +V + + P+ LPE + E+ + EE+ E Q A
Sbjct: 1073 SPQSTSVQAKGTNKLRKPK---LPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAK 1129
Query: 1045 TTATSTAAAAPSTAPSAGSTAGDSGAEDGPASRVSQL 1081
+ T T TA +S +D A S L
Sbjct: 1130 SAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLL 1166
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo
sapiens]
Length = 1450
Score = 97.4 bits (241), Expect = 8e-20
Identities = 210/1050 (20%), Positives = 334/1050 (31%), Gaps = 142/1050 (13%)
Query: 250 PFEPTGSNPSSSAGTPSPEEEEEEEEE----EEEEEEDEEEEEGLSQSISRISETLAGIY 305
P TG ++ SP + E E EEE G + +S A
Sbjct: 140 PHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSS 199
Query: 306 DDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAEACREG 365
+++ S D +P +P Q + + + + +A A G
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPA----------------PG 243
Query: 366 KVSVEVVTAGGAALPPPLL---PPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPTPA 422
KV G ALPP P +SE E EE P S + + + A
Sbjct: 244 KVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAA 303
Query: 423 ---ASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGG 479
A TP P PP + E D E + + + + PAA +
Sbjct: 304 SAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSE-ESSDSEEETPAAKALLQA 362
Query: 480 LDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGT 539
+ + SP APAP GP K +R+ ++ S S
Sbjct: 363 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEE 422
Query: 540 QPAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRR 599
PA P+ + S K ++ ++ + + + D R
Sbjct: 423 APAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEES 482
Query: 600 SRSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGS 659
RE + P S G G G K + + G
Sbjct: 483 DSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWE 542
Query: 660 EKAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPS 719
E + + + S S+ G VP ++ + L I + K P+
Sbjct: 543 EDSESSSEESSDSSD---------GEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAG 593
Query: 720 PAPASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSRE--KGSRRKALDGGD 777
P + + +SE S EE S D + AA +++ ++ K + KA
Sbjct: 594 PVAVQVKAEKPMDNSE--SSEE---SSDSADSEEAPAAMTAAQAKPALKIPQTKACP--- 645
Query: 778 RDRDRDRDRDRDRSSKKARP-------PKESAPSSGPPPKPPVSSG-----SGSSSSSSS 825
+ +S K P P+++ ++ P P +G + SSSS
Sbjct: 646 -------KKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEE 698
Query: 826 CSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIG-----------------VKFSR 868
S + K V V + V K A+ GS+G VK +
Sbjct: 699 SDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEK 758
Query: 869 DRESRSPFLKPDERAPTEMAKAAPGSTKP--KKTKVKAKAGAKKTKGTKG---------- 916
+S S +E + +E A A+P K KKT+ KA A + KG
Sbjct: 759 QEDSES----SEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVT 814
Query: 917 ------KTKPSKTRKKVRSGGGS----GGSGGQVSLKKSKADSCSQAAGTK----GAEET 962
+ PSK + VR+ S G S+ K+ A + G + +EE
Sbjct: 815 AAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEE 874
Query: 963 SWSGEERAAKVPSTPPPKAAPPPPALTPDSQTV-DSSCKTPEVSFLPEEATEEAGVRGGA 1021
S S EE P K AL P ++ + TP P A +AG + +
Sbjct: 875 SDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAA--QAGKQDDS 932
Query: 1022 EEEEEEEEEEEE------------------EEEEEEQQPATTTATSTAAAAPSTAPSAGS 1063
EE + + E + PA T A + AA+ P A ++ S
Sbjct: 933 GSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASES 992
Query: 1064 TAGDSGAEDGPASRVSQLPTLPPPMPWNLPAGVDCTTSGVLALTALLFKMEEANLASRAK 1123
TA S +E + L P + N+ + A + K A +S +
Sbjct: 993 TARSSSSESEDEDVIPATQCLTPGIRTNV-------VTMPTAHPRIAPKASMAGASSSKE 1045
Query: 1124 AQELIQATNQILSHRKPPSSLGMTPAPVPTSLGLPPGPSSYLLPGSLPLGGCGSTPPTPT 1183
+ + Q + S++G PA P S + ++ L LP P
Sbjct: 1046 SSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLP--EVQQATKAPE 1103
Query: 1184 GLAATSDKREGSSSSEGRGDTDKYLKKLHT 1213
+ D + SS SE G+ + K HT
Sbjct: 1104 SSDDSEDSSDSSSGSEEDGEGPQGAKSAHT 1133
Score = 79.3 bits (194), Expect = 2e-14
Identities = 194/919 (21%), Positives = 312/919 (33%), Gaps = 177/919 (19%)
Query: 185 APPPAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEAYSPPP-- 242
A P +S SS S + S +P A PA P+ T + P
Sbjct: 601 AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR 660
Query: 243 ----APEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRIS 298
AP + P GS+P+ + GT P E+ EE + EEE+ GL+ ++ +
Sbjct: 661 VGTQAPRKAGTATSPAGSSPAVAGGTQRP----AEDSSSSEESDSEEEKTGLAVTVGQAK 716
Query: 299 ETLAGIY-------------------------------------DDNSLSQDFPGDESPR 321
G+ D S ++ +E+
Sbjct: 717 SVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAA 776
Query: 322 PDAQ---PTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAEACREGKVSVE-------- 370
AQ + T A P + A G + VV A+A + V+
Sbjct: 777 SPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQN 836
Query: 371 --VVTAGGAALP-----------PPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRA- 416
V+ G A++P P DS E E EE L+ +P G+
Sbjct: 837 STVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEE--SDSEEEAETLAQVKPSGKTH 894
Query: 417 --------ARPTPAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAP 468
A+ +P A PT P A +A + DD S ESD +G
Sbjct: 895 QIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDG----------E 944
Query: 469 APPAADSRWGGLDLRRKILTQRRERYRQRSPS-PAPAPAPAAAAGPPTRKKSRRERKRSG 527
AP A S + I RSP+ PA PA A AA P RK
Sbjct: 945 APAAVTS-------AQVIKPPLIFVDPNRSPAGPAATPAQAQAASTP--------RKARA 989
Query: 528 EAKEAASSSSGTQPAPPAPASPWDSKKHRSR-DRKPGSHASSSARRRSRSRSRSRSTRRR 586
A SSSS ++ PA+ + R+ P +H + + S S+ + R
Sbjct: 990 SESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRI 1049
Query: 587 SRSTDRRRGGSRRSRSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRD------GGGS 640
S ++ G + + S + PATS S+S + + K R +
Sbjct: 1050 S-DGKKQEGPATQVDS---------AVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQAT 1099
Query: 641 KKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFA 700
K + S S GSE+ + + G SR V + + ++ D+ A
Sbjct: 1100 KAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVA 1159
Query: 701 IKRTITVGRLDKSDPRGPSPAPASSPKRE--VLYDSEGLSGEERGGKSSQKDRRRSGAAS 758
+++ G + S A ++PK + S + ++ GK K ++ +G S
Sbjct: 1160 PSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLS 1219
Query: 759 SSSSSREKGSRRKALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSG 818
+ +E S + +K+R PK+ A G P ++ S
Sbjct: 1220 PKTGGKEAAS--------------------GTTPQKSRKPKKGA---GNPQASTLALQSN 1256
Query: 819 SSS---------SSSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFSRD 869
+ + + + VK+ +++ R+ V TT K+++ G S K S D
Sbjct: 1257 ITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTT--KESSRKGWESRKRKLSGD 1314
Query: 870 R-ESRSPFLKPDERAPTEMAKAAPGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVR 928
+ +R+P K ++ + S P+KT +K AK+ K + G K K + +
Sbjct: 1315 QPAARTPRSKKKKKLGA--GEGGEASVSPEKTSTTSKGKAKRDKAS-GDVKEKKGKGSLG 1371
Query: 929 SGG-----------GSGG-SGGQVSLKKSKADSCSQAAGTKGAEETSWSGEERAAKVPST 976
S G G G GG S KSK + K E+ + + A +
Sbjct: 1372 SQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDS 1431
Query: 977 PPPKAAPPPPALTPDSQTV 995
P QTV
Sbjct: 1432 ESPSQKKKKKKKKTAEQTV 1450
Score = 73.9 bits (180), Expect = 9e-13
Identities = 177/938 (18%), Positives = 303/938 (32%), Gaps = 129/938 (13%)
Query: 184 PAPP-PAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEA-YSPP 241
PAPP A + AS + + P S S P A T + +
Sbjct: 317 PAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 376
Query: 242 PAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISETL 301
PA E P + A + + EE+ + EE D EEE S + +
Sbjct: 377 PAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQV 436
Query: 302 AGIYDDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAEA 361
+ P ESPR A P P QV + + R +
Sbjct: 437 R--------AASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSR----------SS 478
Query: 362 CREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPTP 421
E E + A AA PL G S P+ +P + + P G+ A P P
Sbjct: 479 SEESDSDREALAAMNAAQVKPL---GKS---------PQVKPASTMGM-GPLGKGAGPVP 525
Query: 422 AASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGGLD 481
P P + E + S + +G + P PA + G +
Sbjct: 526 PGKVGPAT---PSAQVGKWEEDSESSSEESSDSSDGEV------PTAVAPAQEKSLGNI- 575
Query: 482 LRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQP 541
Q P+ +PA P AGP + + + E+ E +S S+ ++
Sbjct: 576 -------------LQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEE 622
Query: 542 APPA---------------PASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRR 586
AP A A P + S P + + R+ + S + S+
Sbjct: 623 APAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAV 682
Query: 587 SRSTDRRRGGSRRSRSREKRRRR-----------------RRSASPPPATSSSSSSRRER 629
+ T R S S + + + A+ P S
Sbjct: 683 AGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPV 742
Query: 630 HRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPS 689
GK K +K+ S + D E A +PA + S + A PS
Sbjct: 743 LPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKT-SVKKTQAKANPAAARAPS 801
Query: 690 IQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQK 749
+ + A + +T K P +P+ + S G +
Sbjct: 802 AKG----TISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATA 857
Query: 750 DRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPP 809
+ ++G S SS E+ + + + + + + A P + +P G P
Sbjct: 858 AQAQTGPEEDSGSSEEESDSEEEAE----TLAQVKPSGKTHQIRAALAPAKESPRKGAAP 913
Query: 810 KPPVSSGSGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFSRD 869
PP +G ++ + S G SS +++ S G V ++
Sbjct: 914 TPPGKTGPSAAQAGKQDDS---------------GSSS----EESDSDGEAPAAVTSAQV 954
Query: 870 RESRSPFLKPDERAPTEMAKAAPGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRS 929
+ F+ P+ R+P A A P + T KA+A + + +++ +
Sbjct: 955 IKPPLIFVDPN-RSPAGPA-ATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQC 1012
Query: 930 -GGGSGGSGGQVSLKKSKADSCSQAAGTKGAEETSWSGEERAAKVPSTPPPKAAPPPPAL 988
G + + + + AG ++E+S + + + P+T A PA
Sbjct: 1013 LTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPAT 1072
Query: 989 TPDSQTVD----SSCKTPEVSFLPEEATEEAGVRGGAEEEEEEEEEEEEEEEEEEQQPAT 1044
+P S +V + + P+ LPE ++A + ++ E+ + EE+ + P
Sbjct: 1073 SPQSTSVQAKGTNKLRKPK---LPE--VQQATKAPESSDDSEDSSDSSSGSEEDGEGPQG 1127
Query: 1045 TTATSTAAAAPS-TAPSAGSTAGDSGAEDGPASRVSQL 1081
+ T PS T TA +S +D A S L
Sbjct: 1128 AKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLL 1165
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 97.1 bits (240), Expect = 1e-19
Identities = 222/1104 (20%), Positives = 357/1104 (32%), Gaps = 159/1104 (14%)
Query: 219 APPAPRFDIYDPFHPTDEAYSPPPAPEQKYDPFEPTG-SNPSSSAGTPSPEEEEEEEEEE 277
A P DIY + T E A E + T S+P S++ E
Sbjct: 41 AQPVTLLDIYTHWQQTSELGRKRKAEEDAALQAKKTRVSDPISTS------------ESS 88
Query: 278 EEEEEDEEEEEGLSQSISRISETLAGIYDDNSLSQDFPGDESPRPDAQPTQPTPAPG-TP 336
EEEEE E E + ++ + ++ G +S+ + + + P PA G T
Sbjct: 89 EEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTV 148
Query: 337 PQVDSTRADGAMRRRVFVVGTEAEACREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEI 396
+ S ++ +E EG V A GAA P ++ G ++ +
Sbjct: 149 ANLLSGKSPRKSAEPSANTTLVSETEEEGSVP-----AFGAAAKPGMVSAGQADSSSEDT 203
Query: 397 VQPEEEPRLALSLFRPGGRAARPTPAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGE 456
+E + + + + A TP P PP + E D E
Sbjct: 204 SSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSE 263
Query: 457 GALQVDLGEPAPAPPAADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTR 516
+ + + + PAA + + + SP APAP GP
Sbjct: 264 SSSE-ESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVA 322
Query: 517 KKSRRERKRSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRS 576
K +R+ ++ S S PA P+ + S K ++ ++
Sbjct: 323 KAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKT 382
Query: 577 RSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRD 636
+ + + D R RE + P S G
Sbjct: 383 GPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGK 442
Query: 637 GGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDH 696
G G K + + G E + + + S S+ G VP ++ +
Sbjct: 443 GAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSD---------GEVPTAVAPAQEK 493
Query: 697 DLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGA 756
L I + K P+ P + + +SE S EE S D + A
Sbjct: 494 SLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSE--SSEE---SSDSADSEEAPA 548
Query: 757 ASSSSSSRE--KGSRRKALDGGDRDRDRDRDRDRDRSSKKARP-------PKESAPSSGP 807
A +++ ++ K + KA + +S K P P+++ ++ P
Sbjct: 549 AMTAAQAKPALKIPQTKACP----------KKTNTTASAKVAPVRVGTQAPRKAGTATSP 598
Query: 808 PPKPPVSSG-----SGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSI 862
P +G + SSSS S + K V V + V K A+ GS+
Sbjct: 599 AGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSL 658
Query: 863 G-----------------VKFSRDRESRSPFLKPDERAPTEMAKAAPGSTKP--KKTKVK 903
G VK + +S S +E + +E A A+P K KKT+ K
Sbjct: 659 GQGTAPVLPGKTGPTVTQVKAEKQEDSES----SEEESDSEEAAASPAQVKTSVKKTQAK 714
Query: 904 AKAGAKKTKGTKG----------------KTKPSKTRKKVRSGGGS----GGSGGQVSLK 943
A A + KG + PSK + VR+ S G S+
Sbjct: 715 ANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVG 774
Query: 944 KSKADSCSQAAGTK----GAEETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTV-DSS 998
K+ A + G + +EE S S EE P K AL P ++ +
Sbjct: 775 KAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGA 834
Query: 999 CKTPEVSFLPEEATEEAGVRGGAEEEEEEEEEEEE------------------EEEEEEQ 1040
TP P A +AG + + EE + + E +
Sbjct: 835 APTPPGKTGPSAA--QAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPA 892
Query: 1041 QPATTTATSTAAAAPSTAPSAGSTAGDSGAED--------------GPASRVSQLPTLPP 1086
PA T A + AA+ P A ++ STA S +E G + V +PT P
Sbjct: 893 GPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHP 952
Query: 1087 PM-PWNLPAGVDCT-----TSGVLALTALLFKMEEANLASRAKAQELIQATNQILSHRKP 1140
+ P AG + S ++ + N AS Q ++ Q S +P
Sbjct: 953 RIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQP 1012
Query: 1141 P-----------SSLGMTPAPVPTSLGLPPGPSSYLLPGSLPLGGCGSTPPTPTGLAATS 1189
P S++G PA P S + ++ L LP P +
Sbjct: 1013 PVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLP--EVQQATKAPESSDDSE 1070
Query: 1190 DKREGSSSSEGRGDTDKYLKKLHT 1213
D + SS SE G+ + K HT
Sbjct: 1071 DSSDSSSGSEEDGEGPQGAKSAHT 1094
Score = 82.8 bits (203), Expect = 2e-15
Identities = 191/956 (19%), Positives = 298/956 (31%), Gaps = 126/956 (13%)
Query: 184 PAPP-PAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEA-YSPP 241
PAPP A + AS + + P S S P A T + +
Sbjct: 240 PAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 299
Query: 242 PAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISETL 301
PA E P + A + + EE+ + EE D EEE S + +
Sbjct: 300 PAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQV 359
Query: 302 AGIYDDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAEA 361
+ P ESPR A P P QV + + R +
Sbjct: 360 R--------AASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSR----------SS 401
Query: 362 CREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPTP 421
E E + A AA PL G S P+ +P + + P G+ A P P
Sbjct: 402 SEESDSDREALAAMNAAQVKPL---GKS---------PQVKPASTMGM-GPLGKGAGPVP 448
Query: 422 AASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGGLD 481
P P + E + S + +G + P PA + G +
Sbjct: 449 PGKVGPAT---PSAQVGKWEEDSESSSEESSDSSDGEV------PTAVAPAQEKSLGNI- 498
Query: 482 LRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQP 541
Q P+ +PA P AGP + + + E+ E +S S+ ++
Sbjct: 499 -------------LQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEE 545
Query: 542 APPA---------------PASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRR 586
AP A A P + S P + + R+ + S + S+
Sbjct: 546 APAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAV 605
Query: 587 SRSTDRRRGGSRRSRSREKRRRR-----------------RRSASPPPATSSSSSSRRER 629
+ T R S S + + + A+ P S
Sbjct: 606 AGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPV 665
Query: 630 HRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPS 689
GK K +K+ S + D E A +PA + S + A PS
Sbjct: 666 LPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKT-SVKKTQAKANPAAARAPS 724
Query: 690 IQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQK 749
+ + A + +T K P +P+ + S G +
Sbjct: 725 AKGT----ISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATA 780
Query: 750 DRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPP 809
+ ++G S SS E+ + + + + + + A P + +P G P
Sbjct: 781 AQAQTGPEEDSGSSEEESDSEEEAE----TLAQVKPSGKTHQIRAALAPAKESPRKGAAP 836
Query: 810 KPPVSSG-----------SGSSSSSSSCSSRKVKLQSKVAVL------IREGVSSTTPAK 852
PP +G SGSSS S + V+ + S PA
Sbjct: 837 TPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAA 896
Query: 853 DAASAGLGSIGVKFSRDRESRSPFLKPDERAPTEMAKAAPGSTKPKKTKVKAKAGAKKT- 911
A A S K +R ES + E ++ A T +T V A
Sbjct: 897 TPAQAQAASTPRK-ARASESTARS-SSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRI 954
Query: 912 --KGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKKSKADSCSQAAGTKGAEETSWSGEER 969
K + SK ++ G G QVS K + +QAA A++ S +
Sbjct: 955 APKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPV 1014
Query: 970 AAKVPSTPPPKAAPPPPALTPDSQTVDSS----CKTPEVSFLPEEATEEAGVRGGAEEEE 1025
A PS+ A PA +P S +V + + P+ LPE + E+
Sbjct: 1015 ARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPK---LPEVQQATKAPESSDDSED 1071
Query: 1026 EEEEEEEEEEEEEEQQPATTTATSTAAAAPSTAPSAGSTAGDSGAEDGPASRVSQL 1081
+ EE+ E Q A + T T TA +S +D A S L
Sbjct: 1072 SSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLL 1127
Score = 79.3 bits (194), Expect = 2e-14
Identities = 199/948 (20%), Positives = 317/948 (33%), Gaps = 196/948 (20%)
Query: 185 APPPAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEAYSPPP-- 242
A P +S SS S + S +P A PA P+ T + P
Sbjct: 524 AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR 583
Query: 243 ----APEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRIS 298
AP + P GS+P+ + GT P E+ EE + EEE+ GL+ ++ +
Sbjct: 584 VGTQAPRKAGTATSPAGSSPAVAGGTQRP----AEDSSSSEESDSEEEKTGLAVTVGQAK 639
Query: 299 ETLAGIY-------------------------------------DDNSLSQDFPGDESPR 321
G+ D S ++ +E+
Sbjct: 640 SVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAA 699
Query: 322 PDAQ---PTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAEACREGKVSVE-------- 370
AQ + T A P + A G + VV A+A + V+
Sbjct: 700 SPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQN 759
Query: 371 --VVTAGGAALP-----------PPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRA- 416
V+ G A++P P DS E E EE L+ +P G+
Sbjct: 760 STVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEE--SDSEEEAETLAQVKPSGKTH 817
Query: 417 --------ARPTPAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAP 468
A+ +P A PT P A +A + DD S ESD +G
Sbjct: 818 QIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDG----------E 867
Query: 469 APPAADSRWGGLDLRRKILTQRRERYRQRSPS-PAPAPAPAAAAGPPTRKKSRRERKRSG 527
AP A S + I RSP+ PA PA A AA P RK
Sbjct: 868 APAAVTS-------AQVIKPPLIFVDPNRSPAGPAATPAQAQAASTP--------RKARA 912
Query: 528 EAKEAASSSSGTQPAPPAPASPWDSKKHRSR-DRKPGSHASSSARRRSRSRSRSRSTRRR 586
A SSSS ++ PA+ + R+ P +H + + S S+ + R
Sbjct: 913 SESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRI 972
Query: 587 SRSTDRRRGGSRRSRSR-----------EKRRRRRRSASPP-----------------PA 618
S + ++ S+ + ++ A PP PA
Sbjct: 973 SDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPA 1032
Query: 619 TSSSSSSRRERHRGKHRD------GGGSKKKKKRSRSRGEKRSGDGSEK-APAPAPPPSG 671
TS S+S + + K R +K + S S GSE+ P S
Sbjct: 1033 TSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSA 1092
Query: 672 STSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKRE-- 729
T G SR V + + ++ D+ A +++ G + S A ++PK +
Sbjct: 1093 HTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSS 1152
Query: 730 VLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRD 789
S + ++ GK K ++ +G S + +E S
Sbjct: 1153 PSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAAS--------------------G 1192
Query: 790 RSSKKARPPKESAPSSGPPPKPPVSSGSGSSS---------SSSSCSSRKVKLQSKVAVL 840
+ +K+R PK+ A G P ++ S + + + + VK+ +++
Sbjct: 1193 TTPQKSRKPKKGA---GNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQ 1249
Query: 841 IREGVSSTTPAKDAASAGLGSIGVKFSRDR-ESRSPFLKPDERAPTEMAKAAPGSTKPKK 899
R+ V TT K+++ G S K S D+ +R+P K ++ + S P+K
Sbjct: 1250 ERKKVVDTT--KESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGA--GEGGEASVSPEK 1305
Query: 900 TKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGG-----------GSGG-SGGQVSLKKSKA 947
T +K AK+ K + G K K + + S G G G GG S KSK
Sbjct: 1306 TSTTSKGKAKRDKAS-GDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKK 1364
Query: 948 DSCSQAAGTKGAEETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTV 995
+ K E+ + + A + P QTV
Sbjct: 1365 EKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAEQTV 1412
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b [Homo
sapiens]
Length = 1411
Score = 97.1 bits (240), Expect = 1e-19
Identities = 222/1104 (20%), Positives = 357/1104 (32%), Gaps = 159/1104 (14%)
Query: 219 APPAPRFDIYDPFHPTDEAYSPPPAPEQKYDPFEPTG-SNPSSSAGTPSPEEEEEEEEEE 277
A P DIY + T E A E + T S+P S++ E
Sbjct: 41 AQPVTLLDIYTHWQQTSELGRKRKAEEDAALQAKKTRVSDPISTS------------ESS 88
Query: 278 EEEEEDEEEEEGLSQSISRISETLAGIYDDNSLSQDFPGDESPRPDAQPTQPTPAPG-TP 336
EEEEE E E + ++ + ++ G +S+ + + + P PA G T
Sbjct: 89 EEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTV 148
Query: 337 PQVDSTRADGAMRRRVFVVGTEAEACREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEI 396
+ S ++ +E EG V A GAA P ++ G ++ +
Sbjct: 149 ANLLSGKSPRKSAEPSANTTLVSETEEEGSVP-----AFGAAAKPGMVSAGQADSSSEDT 203
Query: 397 VQPEEEPRLALSLFRPGGRAARPTPAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGE 456
+E + + + + A TP P PP + E D E
Sbjct: 204 SSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSE 263
Query: 457 GALQVDLGEPAPAPPAADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTR 516
+ + + + PAA + + + SP APAP GP
Sbjct: 264 SSSE-ESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVA 322
Query: 517 KKSRRERKRSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRS 576
K +R+ ++ S S PA P+ + S K ++ ++
Sbjct: 323 KAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKT 382
Query: 577 RSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRD 636
+ + + D R RE + P S G
Sbjct: 383 GPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGK 442
Query: 637 GGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDH 696
G G K + + G E + + + S S+ G VP ++ +
Sbjct: 443 GAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSD---------GEVPTAVAPAQEK 493
Query: 697 DLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGA 756
L I + K P+ P + + +SE S EE S D + A
Sbjct: 494 SLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSE--SSEE---SSDSADSEEAPA 548
Query: 757 ASSSSSSRE--KGSRRKALDGGDRDRDRDRDRDRDRSSKKARP-------PKESAPSSGP 807
A +++ ++ K + KA + +S K P P+++ ++ P
Sbjct: 549 AMTAAQAKPALKIPQTKACP----------KKTNTTASAKVAPVRVGTQAPRKAGTATSP 598
Query: 808 PPKPPVSSG-----SGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSI 862
P +G + SSSS S + K V V + V K A+ GS+
Sbjct: 599 AGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSL 658
Query: 863 G-----------------VKFSRDRESRSPFLKPDERAPTEMAKAAPGSTKP--KKTKVK 903
G VK + +S S +E + +E A A+P K KKT+ K
Sbjct: 659 GQGTAPVLPGKTGPTVTQVKAEKQEDSES----SEEESDSEEAAASPAQVKTSVKKTQAK 714
Query: 904 AKAGAKKTKGTKG----------------KTKPSKTRKKVRSGGGS----GGSGGQVSLK 943
A A + KG + PSK + VR+ S G S+
Sbjct: 715 ANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVG 774
Query: 944 KSKADSCSQAAGTK----GAEETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTV-DSS 998
K+ A + G + +EE S S EE P K AL P ++ +
Sbjct: 775 KAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGA 834
Query: 999 CKTPEVSFLPEEATEEAGVRGGAEEEEEEEEEEEE------------------EEEEEEQ 1040
TP P A +AG + + EE + + E +
Sbjct: 835 APTPPGKTGPSAA--QAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPA 892
Query: 1041 QPATTTATSTAAAAPSTAPSAGSTAGDSGAED--------------GPASRVSQLPTLPP 1086
PA T A + AA+ P A ++ STA S +E G + V +PT P
Sbjct: 893 GPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHP 952
Query: 1087 PM-PWNLPAGVDCT-----TSGVLALTALLFKMEEANLASRAKAQELIQATNQILSHRKP 1140
+ P AG + S ++ + N AS Q ++ Q S +P
Sbjct: 953 RIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQP 1012
Query: 1141 P-----------SSLGMTPAPVPTSLGLPPGPSSYLLPGSLPLGGCGSTPPTPTGLAATS 1189
P S++G PA P S + ++ L LP P +
Sbjct: 1013 PVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLP--EVQQATKAPESSDDSE 1070
Query: 1190 DKREGSSSSEGRGDTDKYLKKLHT 1213
D + SS SE G+ + K HT
Sbjct: 1071 DSSDSSSGSEEDGEGPQGAKSAHT 1094
Score = 76.6 bits (187), Expect = 1e-13
Identities = 197/947 (20%), Positives = 315/947 (33%), Gaps = 195/947 (20%)
Query: 185 APPPAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEAYSPPP-- 242
A P +S SS S + S +P A PA P+ T + P
Sbjct: 524 AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR 583
Query: 243 ----APEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRIS 298
AP + P GS+P+ + GT P E+ EE + EEE + GL+ ++ +
Sbjct: 584 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEE----KTGLAVTVGQAK 639
Query: 299 ETLAGIY-------------------------------------DDNSLSQDFPGDESPR 321
G+ D S ++ +E+
Sbjct: 640 SVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAA 699
Query: 322 PDAQ---PTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAEACREGKVSVE-------- 370
AQ + T A P + A G + VV A+A + V+
Sbjct: 700 SPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQN 759
Query: 371 --VVTAGGAALPP-----------PLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRA- 416
V+ G A++P P DS E E EE LA +P G+
Sbjct: 760 STVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQ--VKPSGKTH 817
Query: 417 --------ARPTPAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAP 468
A+ +P A PT P A +A + DD S ESD +G
Sbjct: 818 QIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGE---------- 867
Query: 469 APPAADSRWGGLDLRRKILTQRRERYRQRSPS-PAPAPAPAAAAGPPTRKKSRRERKRSG 527
AP A S + I RSP+ PA PA A AA P RK
Sbjct: 868 APAAVTSA-------QVIKPPLIFVDPNRSPAGPAATPAQAQAASTP--------RKARA 912
Query: 528 EAKEAASSSSGTQPAPPAPASPWDSKKHRSRD-RKPGSHASSSARRRSRSRSRSRSTRRR 586
A SSSS ++ PA+ + R+ P +H + + S S+ + R
Sbjct: 913 SESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRI 972
Query: 587 SRSTDRRRGGSRRSRSREKR-----------RRRRRSASPP-----------------PA 618
S + ++ S+ ++ A PP PA
Sbjct: 973 SDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPA 1032
Query: 619 TSSSSSSRRERHRGKHRDGG------GSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGS 672
TS S+S + + K R +K + S S GSE+ +
Sbjct: 1033 TSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSA 1092
Query: 673 TSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVL- 731
+ G SR V + + ++ D+ A +++ G + S A ++PK +
Sbjct: 1093 HTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSP 1152
Query: 732 -YDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDR 790
S + ++ GK K ++ +G S + +E S
Sbjct: 1153 SVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAAS--------------------GT 1192
Query: 791 SSKKARPPKESAPSSGPPPKPPVSSGSGSSS---------SSSSCSSRKVKLQSKVAVLI 841
+ +K+R PK+ A G P ++ S + + + + VK+ +++
Sbjct: 1193 TPQKSRKPKKGA---GNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQE 1249
Query: 842 REGVSSTTPAKDAASAGLGSIGVKFSRDRES-RSPFLKPDERAPTEMAKAAPGSTKPKKT 900
R+ V TT K+++ G S K S D+ + R+P K ++ + S P+KT
Sbjct: 1250 RKKVVDTT--KESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGA--GEGGEASVSPEKT 1305
Query: 901 KVKAKAGAKKTKGTKGKTKPSKTRKKVRSGG-----------GSGG-SGGQVSLKKSKAD 948
+K AK+ K + G K K + + S G G G GG S KSK +
Sbjct: 1306 STTSKGKAKRDKAS-GDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKE 1364
Query: 949 SCSQAAGTKGAEETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTV 995
K E+ + + A + P QTV
Sbjct: 1365 KKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAEQTV 1411
Score = 72.8 bits (177), Expect = 2e-12
Identities = 243/1179 (20%), Positives = 392/1179 (33%), Gaps = 157/1179 (13%)
Query: 141 PLPVPSLLPRLRAWRTGKTVSP-QSNSSRPTCARHLTLGTGDGGPAPPPAPSSASSSPSP 199
P P P + + GK QS+S G AP +SA
Sbjct: 311 PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASA------ 364
Query: 200 SPSSSSPSPPPPPPPPAPPAPPAPRFDI----YDPFHPTDEAYS-------------PPP 242
P+ SP P PP P A + + D ++E+ S P
Sbjct: 365 -PAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 423
Query: 243 APEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISETLA 302
+ P G P P P + + + EE+ E S+ S S
Sbjct: 424 GKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSS---- 479
Query: 303 GIYDDNSLSQDFPGDESPRPDAQPTQPTPAPGT-PPQVDSTRADGAMRRRVFVVGTEAEA 361
D + P E + +PT +P PPQ A + +E
Sbjct: 480 ---DGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEE 536
Query: 362 CREGKVSVEVVTAGGAALPPPLLP-------PGDSEIEEGEIVQPEEEPRLALSLFRPGG 414
+ S E A AA P L P + V P R+ R G
Sbjct: 537 SSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAP---VRVGTQAPRKAG 593
Query: 415 RAARPTPAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAAD 474
A P ++ A P + + E D +E + G L V +G+ A
Sbjct: 594 TATSPAGSSPAVAGGTQRPAEDSSSSEESD------SEEEKTG-LAVTVGQ-------AK 639
Query: 475 SRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAAS 534
S GL ++ + + S AP G PT + + E++ E+ E S
Sbjct: 640 SVGKGLQVKAASVPVK------GSLGQGTAPVLPGKTG-PTVTQVKAEKQEDSESSEEES 692
Query: 535 SSSGTQPAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSR--SRSTRRRSRSTDR 592
S + A +PA S K P + + SA+ + + + + + + RS +
Sbjct: 693 DS---EEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSK 749
Query: 593 RRGGSRRSRSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGE 652
+ R ++ R S P+ + ++ + G D G S+++
Sbjct: 750 VKPPVRNPQNSTVLARGPASV---PSVGKAVATAAQAQTGPEEDSGSSEEE--------- 797
Query: 653 KRSGDGSEKAPAPAP-PPSGSTS------CGDRDSRRRGAVPPSIQDLTDHDLFAIKRTI 705
D E+A A PSG T ++S R+GA P A K+
Sbjct: 798 ---SDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDD 854
Query: 706 TVGRLDKSDPRGPSPAPASSP---KREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSS 762
+ ++SD G +PA +S K +++ S +Q A ++S+
Sbjct: 855 SGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQ-------AQAASTP 907
Query: 763 SREKGSRRKALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSS 822
+ + S A D D + R + P++ P P S SSS
Sbjct: 908 RKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSK 967
Query: 823 SSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKF--SRDRESRSPFLKPD 880
SS S K +EG ++ K+ AS L +K + E++ P +
Sbjct: 968 ESSRISDGKK---------QEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQ 1018
Query: 881 ERAPTEMAKAAPGSTKPKKTKVKAKAGAKKTK--------GTKGKTKPSKTRKKVRSGGG 932
+ + A +T P+ T V+AK K K TK + S G
Sbjct: 1019 PSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSG 1078
Query: 933 SGGSG-GQVSLKKSKADSCSQAAGTKGAEETSWSGEERAAKVPSTPPPKAAPPPPALTPD 991
S G G K + + + EET+ E PS + P LTP
Sbjct: 1079 SEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPS-QSLLSGYMTPGLTPA 1137
Query: 992 SQTVDSSCKTPEVSFLPEEATEEAGVRGGAEEEEEEEEEEEEEEEEEEQQPATTTATSTA 1051
+ +S TP++ P ++ A A+++ + ++E + ++ P T + +
Sbjct: 1138 NS--QASKATPKLDSSPSVSSTLA-----AKDDPDGKQEAKPQQAAGMLSPKTGGKEAAS 1190
Query: 1052 AAAPSTAPSAGSTAGDSGAED-GPASRVSQLPTLPPPMPWNLPAGVDCTTSGVLALTALL 1110
P + AG+ A S ++Q L P P N S V LT LL
Sbjct: 1191 GTTPQKSRKPKKGAGNPQASTLALQSNITQC-LLGQPWPLN---EAQVQASVVKVLTELL 1246
Query: 1111 FKMEEANLASRAKAQELIQATNQILSHRKPPSSLGMTPAPVPTS-----LGLPPGPSSYL 1165
+ E + K +++ + RK S A P S LG G + +
Sbjct: 1247 -EQERKKVVDTTK-----ESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASV 1300
Query: 1166 LPGSLPLGGCGSTPPTPTGLAATSDKREGSSSSEGRGD--TDKYLKKLHTQE-------R 1216
P G K +GS S+G D ++ K + T E +
Sbjct: 1301 SPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPK 1360
Query: 1217 AVEEVKLAIKPYYQKKDITKEEYKDILRKAVHKICHSKS 1255
+ +E K + K +KKD K+E K +KA K S S
Sbjct: 1361 SKKEKKKSDK---RKKDKEKKEKKKKAKKASTKDSESPS 1396
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 95.1 bits (235), Expect = 4e-19
Identities = 219/1081 (20%), Positives = 343/1081 (31%), Gaps = 166/1081 (15%)
Query: 250 PFEPTGSNPSSSAGTPSPEEEEEEEEE----EEEEEEDEEEEEGLSQSISRISETLAGIY 305
P TG ++ SP + E E EEE G + +S A
Sbjct: 140 PHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSS 199
Query: 306 DDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAEACREG 365
+++ S D +P +P Q + + + + +A A G
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPA----------------PG 243
Query: 366 KVSVEVVTAGGAALPPPLL---PPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPTPA 422
KV G ALPP P +SE E EE P S + + + A
Sbjct: 244 KVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAA 303
Query: 423 ---ASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGG 479
A TP P PP + E D E + + + + PAA +
Sbjct: 304 SAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSE-ESSDSEEETPAAKALLQA 362
Query: 480 LDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGT 539
+ + SP APAP GP K +R+ ++ S S
Sbjct: 363 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEE 422
Query: 540 QPAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRR 599
PA P+ + S K ++ ++ + + + D R
Sbjct: 423 APAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEES 482
Query: 600 SRSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGS 659
RE + P S G G G K + + G
Sbjct: 483 DSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWE 542
Query: 660 EKAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPS 719
E + + + S S+ G VP ++ + L I + K P+
Sbjct: 543 EDSESSSEESSDSSD---------GEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAG 593
Query: 720 PAPASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSRE--KGSRRKALDGGD 777
P + + +SE S EE S D + AA +++ ++ K + KA
Sbjct: 594 PVAVQVKAEKPMDNSE--SSEE---SSDSADSEEAPAAMTAAQAKPALKIPQTKACP--- 645
Query: 778 RDRDRDRDRDRDRSSKKARP-------PKESAPSSGPPPKPPVSSG-----SGSSSSSSS 825
+ +S K P P+++ ++ P P +G + SSSS
Sbjct: 646 -------KKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEE 698
Query: 826 CSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIG-----------------VKFSR 868
S + K V V + V K A+ GS+G VK +
Sbjct: 699 SDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEK 758
Query: 869 DRESRSPFLKPDERAPTEMAKAAPGSTKP--KKTKVKAKAGAKKTKGTKG---------- 916
+S S +E + +E A A+P K KKT+ KA A + KG
Sbjct: 759 QEDSES----SEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVT 814
Query: 917 ------KTKPSKTRKKVRSGGGS----GGSGGQVSLKKSKADSCSQAAGTK----GAEET 962
+ PSK + VR+ S G S+ K+ A + G + +EE
Sbjct: 815 AAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEE 874
Query: 963 SWSGEERAAKVPSTPPPKAAPPPPALTPDSQTV-DSSCKTPEVSFLPEEATEEAGVRGGA 1021
S S EE P K AL P ++ + TP P A +AG + +
Sbjct: 875 SDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAA--QAGKQDDS 932
Query: 1022 EEEEEEEEEEEE------------------EEEEEEQQPATTTATSTAAAAPSTAPSAGS 1063
EE + + E + PA T A + AA+ P A ++ S
Sbjct: 933 GSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASES 992
Query: 1064 TAGDSGAED--------------GPASRVSQLPTLPPPM-PWNLPAGVDCT-----TSGV 1103
TA S +E G + V +PT P + P AG + S
Sbjct: 993 TARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDG 1052
Query: 1104 LALTALLFKMEEANLASRAKAQELIQATNQILSHRKPP-----------SSLGMTPAPVP 1152
++ + N AS Q ++ Q S +PP S++G PA P
Sbjct: 1053 KKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSP 1112
Query: 1153 TSLGLPPGPSSYLLPGSLPLGGCGSTPPTPTGLAATSDKREGSSSSEGRGDTDKYLKKLH 1212
S + ++ L LP P + D + SS SE G+ + K H
Sbjct: 1113 QSTSVQAKGTNKLRKPKLP--EVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAH 1170
Query: 1213 T 1213
T
Sbjct: 1171 T 1171
Score = 82.4 bits (202), Expect = 3e-15
Identities = 192/957 (20%), Positives = 304/957 (31%), Gaps = 129/957 (13%)
Query: 184 PAPP-PAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEA-YSPP 241
PAPP A + AS + + P S S P A T + +
Sbjct: 317 PAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 376
Query: 242 PAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISETL 301
PA E P + A + + EE+ + EE D EEE S + +
Sbjct: 377 PAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQV 436
Query: 302 AGIYDDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAEA 361
+ P ESPR A P P QV + + R +
Sbjct: 437 R--------AASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSR----------SS 478
Query: 362 CREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPTP 421
E E + A AA PL G S P+ +P + + P G+ A P P
Sbjct: 479 SEESDSDREALAAMNAAQVKPL---GKS---------PQVKPASTMGM-GPLGKGAGPVP 525
Query: 422 AASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGGLD 481
P P + E + S + +G + P PA + G +
Sbjct: 526 PGKVGPAT---PSAQVGKWEEDSESSSEESSDSSDGEV------PTAVAPAQEKSLGNI- 575
Query: 482 LRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQP 541
Q P+ +PA P AGP + + + E+ E +S S+ ++
Sbjct: 576 -------------LQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEE 622
Query: 542 APPA---------------PASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRR 586
AP A A P + S P + + R+ + S + S+
Sbjct: 623 APAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAV 682
Query: 587 SRSTDRRRGGSRRSRSREKRRRR-----------------RRSASPPPATSSSSSSRRER 629
+ T R S S + + + A+ P S
Sbjct: 683 AGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPV 742
Query: 630 HRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPS 689
GK K +K+ S + D E A +PA + S + A PS
Sbjct: 743 LPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKT-SVKKTQAKANPAAARAPS 801
Query: 690 IQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQK 749
+ + A + +T K P +P+ + S G +
Sbjct: 802 AKGT----ISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATA 857
Query: 750 DRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPP 809
+ ++G S SS E+ + + + + + + A P + +P G P
Sbjct: 858 AQAQTGPEEDSGSSEEESDSEEEAE----TLAQVKPSGKTHQIRAALAPAKESPRKGAAP 913
Query: 810 KPPVSSG-----------SGSSSSSSSCSSRKVKLQSKVAVL------IREGVSSTTPAK 852
PP +G SGSSS S + V+ + S PA
Sbjct: 914 TPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAA 973
Query: 853 DAASAGLGSIGVKFSRDRESRSPFLKPDERAPTEMAKAAPGSTKPKKTKVKAKAGAKKT- 911
A A S K +R ES + E ++ A T +T V A
Sbjct: 974 TPAQAQAASTPRK-ARASESTARS-SSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRI 1031
Query: 912 --KGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKKSKADSCSQAAGTKGAEETSWSGEER 969
K + SK ++ G G QVS K + +QAA A++ S +
Sbjct: 1032 APKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPV 1091
Query: 970 AAKVPSTPPPKAAPPPPALTPDSQTVDSS----CKTPEVSFLPEEATEEAGVRGGAEEEE 1025
A PS+ A PA +P S +V + + P+ LPE ++A + ++
Sbjct: 1092 ARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPK---LPE--VQQATKAPESSDDS 1146
Query: 1026 EEEEEEEEEEEEEEQQPATTTATSTAAAAPS-TAPSAGSTAGDSGAEDGPASRVSQL 1081
E+ + EE+ + P + T PS T TA +S +D A S L
Sbjct: 1147 EDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLL 1203
Score = 76.6 bits (187), Expect = 1e-13
Identities = 196/947 (20%), Positives = 316/947 (33%), Gaps = 195/947 (20%)
Query: 185 APPPAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEAYSPPP-- 242
A P +S SS S + S +P A PA P+ T + P
Sbjct: 601 AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR 660
Query: 243 ----APEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRIS 298
AP + P GS+P+ + GT P E+ EE + EEE+ GL+ ++ +
Sbjct: 661 VGTQAPRKAGTATSPAGSSPAVAGGTQRP----AEDSSSSEESDSEEEKTGLAVTVGQAK 716
Query: 299 ETLAGIY-------------------------------------DDNSLSQDFPGDESPR 321
G+ D S ++ +E+
Sbjct: 717 SVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAA 776
Query: 322 PDAQ---PTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAEACREGKVSVE-------- 370
AQ + T A P + A G + VV A+A + V+
Sbjct: 777 SPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQN 836
Query: 371 --VVTAGGAALP-----------PPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRA- 416
V+ G A++P P DS E E EE L+ +P G+
Sbjct: 837 STVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEE--SDSEEEAETLAQVKPSGKTH 894
Query: 417 --------ARPTPAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAP 468
A+ +P A PT P A +A + DD S ESD +G
Sbjct: 895 QIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDG----------E 944
Query: 469 APPAADSRWGGLDLRRKILTQRRERYRQRSPS-PAPAPAPAAAAGPPTRKKSRRERKRSG 527
AP A S + I RSP+ PA PA A AA P RK
Sbjct: 945 APAAVTS-------AQVIKPPLIFVDPNRSPAGPAATPAQAQAASTP--------RKARA 989
Query: 528 EAKEAASSSSGTQPAPPAPASPWDSKKHRSR-DRKPGSHASSSARRRSRSRSRSRSTRRR 586
A SSSS ++ PA+ + R+ P +H + + S S+ + R
Sbjct: 990 SESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRI 1049
Query: 587 SRSTDRRRGGSRRSRSR-----------EKRRRRRRSASPP-----------------PA 618
S + ++ S+ + ++ A PP PA
Sbjct: 1050 SDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPA 1109
Query: 619 TSSSSSSRRERHRGKHRD------GGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGS 672
TS S+S + + K R +K + S S GSE+ +
Sbjct: 1110 TSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSA 1169
Query: 673 TSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKRE--V 730
+ G SR V + + ++ D+ A +++ G + S A ++PK +
Sbjct: 1170 HTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSP 1229
Query: 731 LYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDR 790
S + ++ GK K ++ +G S + +E S
Sbjct: 1230 SVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAAS--------------------GT 1269
Query: 791 SSKKARPPKESAPSSGPPPKPPVSSGSGSSS---------SSSSCSSRKVKLQSKVAVLI 841
+ +K+R PK+ A G P ++ S + + + + VK+ +++
Sbjct: 1270 TPQKSRKPKKGA---GNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQE 1326
Query: 842 REGVSSTTPAKDAASAGLGSIGVKFSRDR-ESRSPFLKPDERAPTEMAKAAPGSTKPKKT 900
R+ V TT K+++ G S K S D+ +R+P K ++ + S P+KT
Sbjct: 1327 RKKVVDTT--KESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGA--GEGGEASVSPEKT 1382
Query: 901 KVKAKAGAKKTKGTKGKTKPSKTRKKVRSGG-----------GSGG-SGGQVSLKKSKAD 948
+K AK+ K + G K K + + S G G G GG S KSK +
Sbjct: 1383 STTSKGKAKRDKAS-GDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKE 1441
Query: 949 SCSQAAGTKGAEETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTV 995
K E+ + + A + P QTV
Sbjct: 1442 KKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAEQTV 1488
>gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens]
Length = 953
Score = 95.1 bits (235), Expect = 4e-19
Identities = 195/947 (20%), Positives = 306/947 (32%), Gaps = 177/947 (18%)
Query: 237 AYSPPPAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISR 296
A P E + E S P S E EEE +E EE + +
Sbjct: 55 ARGPSQEEEDNHSDEEDRASEPKSQDQDSEVNELSRGPTSSPCEEEGDEGEEDRTSDLRD 114
Query: 297 ISETLAGIYDDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRR----V 352
+ ++ D++ L D +E P A Q A + D + +G R V
Sbjct: 115 EASSVTRELDEHELDYD---EEVPEEPAPAVQEDEAEKAGAEDDEEKGEGTPREEGKAGV 171
Query: 353 FVVGTE--AEACREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEIVQPEE---EPRLAL 407
VG + EA +E K + + D ++EEGE+ P + PR
Sbjct: 172 QSVGEKESLEAAKEKKKEDDDGEIDDGEI-------DDDDLEEGEVKDPSDRKVRPRPTC 224
Query: 408 SLFRPGG-------RAARP--TPAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGA 458
F G R P + + + P PP P G L + A G
Sbjct: 225 RFFMKGNCTWGMNCRFIHPGVNDKGNYSLITKADPFPPNGAPPLGPHPL-MPANPWGGPV 283
Query: 459 LQVDLGEPAPAPPAADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKK 518
+ L P P PP + GL +++L ++ R+ G R+
Sbjct: 284 VDEILPPPPPEPPTESAWERGLRHAKEVL--KKATIRKEQEPDFEEKRFTVTIGEDEREF 341
Query: 519 SRRERKRSGEAKEAASSSSGTQPAPPA-PASPWDSKK-------HRSRDRKPGSHASSSA 570
+ T P A P ++ ++ R + + +
Sbjct: 342 DKENEVFRDWNSRIPRDVRDTVLEPYADPYYDYEIERFWRGGQYENFRVQYTETEPYHNY 401
Query: 571 RRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPATSSSSSSRRERH 630
R R R R R R R R +R R RR R RE+ R R RR+
Sbjct: 402 RERERERERENRQRERERERERDRERERRQREREREREHER---------DKERQRRKEE 452
Query: 631 RGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPSI 690
+ R K ++ R R R ++R + + P PPS +++ G
Sbjct: 453 WERERAKRDEKDRQHRDRDREKEREKEKGKPKPRSPQPPSRQAEPPKKEAATTGPQVKRA 512
Query: 691 QDLTDHDLFAIKRTITVGRLDKSDPR--GPSPAPASSPKREVLYDSEGLSGEERGGKSSQ 748
+ D R KS + G S +P+ + +R S + +SS
Sbjct: 513 DEWKD-----------PWRRSKSPKKKLGVSVSPSRARRRR--KTSASSASASNSSRSSS 559
Query: 749 KDRRRSGAASSSSSSREKG-------SRRKALDGGDRDRDR------------DRDRDRD 789
+ SG+ SS S SR S R + G R R R R
Sbjct: 560 RSSSYSGSGSSRSRSRSSSYSSYSSRSSRHSSFSGSRSRSRSFSSSPSPSPTPSPHRPSI 619
Query: 790 RSSKKARPP-----KESAPSSGPPPKPPVS------------------------------ 814
R+ + PP ++S PPP PP +
Sbjct: 620 RTKGEPAPPPGKAGEKSVKKPAPPPAPPQATKTTAPVPEPTKPGDPREARRKERPARTPP 679
Query: 815 -------SGSGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFS 867
SGSGS SS S SSR L + SS++ A S + +
Sbjct: 680 RRRTLSGSGSGSGSSYSGSSSRSRSLSVSSVSSVSSATSSSSSAHSVDSEDMYA------ 733
Query: 868 RDRESRSPFLKPDERAPTEMAKAAPGSTKPKKTKVKAKAGAKKTKGTK-GKTKPSKTRKK 926
+ SP R+P AP T+ +K K K + G K+ K + T+P K+ K
Sbjct: 734 ---DLASPVSSASSRSP------APAQTRKEKGKSKKEDGVKEEKRKRDSSTQPPKSAKP 784
Query: 927 VRSGGGSGGSGGQVSLKKSKADSCSQAAGT-------------KGAEETSWSGEERAAKV 973
+GG Q +A GT K A++ S E + K
Sbjct: 785 -----PAGGKSSQQPSTPQQAPPGQPQQGTFVAHKEIKLTLLNKAADKGSRKRYEPSDKD 839
Query: 974 PSTPPPKAAPPPPALTPDSQTVDSSCKTPEVSFLPEEATEEAGVRGGAEEEEEEEEEEEE 1033
+PPP P +PD + D ++G R G+ + E + + +
Sbjct: 840 RQSPPPAKR---PNTSPDRGSRD----------------RKSGGRLGSPKPERQRGQNSK 880
Query: 1034 EEEEEEQQPATTTATSTAAAAPSTAPSAGSTAGDSGAEDGPASRVSQ 1080
+ + S +++ ++ P S G + + G AS +S+
Sbjct: 881 APAAPADRKRQLSPQSKSSSKVTSVPGKASDPGAASTKSGKASTLSR 927
Score = 50.1 bits (118), Expect = 1e-05
Identities = 85/360 (23%), Positives = 120/360 (33%), Gaps = 62/360 (17%)
Query: 192 SASSSPSPSPSSSSPS------PPPPP---------PPPAPPAPPAPRFDIYDPFHPTDE 236
S+S SPSP+PS PS P PPP P PPAPP +
Sbjct: 603 SSSPSPSPTPSPHRPSIRTKGEPAPPPGKAGEKSVKKPAPPPAPP-----------QATK 651
Query: 237 AYSPPPAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISR 296
+P P P + DP E A TP S S+S
Sbjct: 652 TTAPVPEPTKPGDPRE--ARRKERPARTPPRRRTLSGSGSGSGSSYSGSSSRSRSLSVSS 709
Query: 297 ISETLAGIYDDNSL----SQDFPGD-ESPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRR 351
+S + +S S+D D SP A P PA + S + DG +
Sbjct: 710 VSSVSSATSSSSSAHSVDSEDMYADLASPVSSASSRSPAPAQTRKEKGKSKKEDGVKEEK 769
Query: 352 VFVVGTEAEACREGKVSVEVVTAGGAALPPPL---LPPGDSEIEEGEIVQPEEEPRLALS 408
+ ++ + S + G ++ P PPG + ++G V +E L+
Sbjct: 770 -----RKRDSSTQPPKSAKPPAGGKSSQQPSTPQQAPPG--QPQQGTFVAHKEIKLTLLN 822
Query: 409 LFRPGGRAARPTPAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDG-----EGALQVDL 463
G R P+ + PPA R D S +S G + Q
Sbjct: 823 KAADKGSRKRYEPSDKDRQS-----PPPAKRPNTSPDRGSRDRKSGGRLGSPKPERQRGQ 877
Query: 464 GEPAPAPPAADSRWGGLDLRRKILTQRRERYRQRS-PSPAPAPAPAAAAGPPTRKKSRRE 522
APA PA D +R++ Q + + S P A P A+ SRRE
Sbjct: 878 NSKAPAAPA--------DRKRQLSPQSKSSSKVTSVPGKASDPGAASTKSGKASTLSRRE 929
Score = 40.0 bits (92), Expect = 0.015
Identities = 49/217 (22%), Positives = 72/217 (33%), Gaps = 38/217 (17%)
Query: 139 PIPLPVPSLLPRLRAWRT-GKTVSPQSNSSRPTCARHLTLGTGDGGPAPPPAPSSASSSP 197
P P P PS P + RT G+ P + + + PAPPPAP A+ +
Sbjct: 606 PSPSPTPS--PHRPSIRTKGEPAPPPGKAGEKSVKK----------PAPPPAPPQATKTT 653
Query: 198 SPSPSSSSPSPPPPPPPPAPPAPPAPR------------------------FDIYDPFHP 233
+P P + P P PA PR +
Sbjct: 654 APVPEPTKPGDPREARRKERPARTPPRRRTLSGSGSGSGSSYSGSSSRSRSLSVSSVSSV 713
Query: 234 TDEAYSPPPAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQS 293
+ S A + ++P SSA + SP + +E+ + ++ED +EE +
Sbjct: 714 SSATSSSSSAHSVDSEDMYADLASPVSSASSRSPAPAQTRKEKGKSKKEDGVKEEKRKRD 773
Query: 294 ISRISETLAGIYDDNSLSQDFPGDESPRPDAQPTQPT 330
S A SQ P P QP Q T
Sbjct: 774 SSTQPPKSAKPPAGGKSSQQ-PSTPQQAPPGQPQQGT 809
Score = 33.9 bits (76), Expect = 1.1
Identities = 18/60 (30%), Positives = 31/60 (51%), Gaps = 3/60 (5%)
Query: 1013 EEAGVRGGAEEEEEEEEEEEEEEEEEEQQPATTTATSTAAAAPSTAPSAGSTAGDSGAED 1072
EE+ RG ++EEE+ +EE+ E + Q + + + P+++P GD G ED
Sbjct: 51 EESAARGPSQEEEDNHSDEEDRASEPKSQD-QDSEVNELSRGPTSSPC--EEEGDEGEED 107
>gi|158854042 hypothetical protein LOC222183 [Homo sapiens]
Length = 653
Score = 92.0 bits (227), Expect = 3e-18
Identities = 110/433 (25%), Positives = 163/433 (37%), Gaps = 53/433 (12%)
Query: 508 AAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHAS 567
++A+ PP +KK ++ R K S + P KKHR RDR +
Sbjct: 162 SSASPPPKKKKKKKGGHRRSRKKRRLESECSCGSSSPLRKKKKSVKKHR-RDR-----SD 215
Query: 568 SSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPATSSSSSSRR 627
S +RR+ R RSRS +R+ ++ +++R + R R S SP ++ S S
Sbjct: 216 SGSRRKRRHRSRSSKCKRKEKNKEKKRPHTESPGRRSHRHSSGSSHSPSLSSHYSDSRSP 275
Query: 628 ERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVP 687
R KHRD G ++ S SR SG + P + G R S G P
Sbjct: 276 SRLSPKHRDEGRKTGSQRSSGSRSPSPSGGSGWGS------PQRNGGSGQR-SGAHGGRP 328
Query: 688 PSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPA---SSPKREVLYDSEGLSGEERG- 743
S D R DK+ P+P PA SP S+G G G
Sbjct: 329 GSAHSPPDKPSSPSPRV-----RDKAAAAAPTP-PARGKESPSPRSAPSSQGRGGRAAGG 382
Query: 744 -GKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDRSSKKARPPKESA 802
G+ ++ RRR + SS+S+ R +G RR R RS +AR +S
Sbjct: 383 AGRRRRRRRRRRRSRSSASAPRRRGRRRPR---------PAPPRGSSRSLSRARSSSDSG 433
Query: 803 PSSGPP-PKPPVSSGSGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGS 861
G P P P S G R + + +ST+P+ A G
Sbjct: 434 SGRGAPGPGPEPGSERGHGGHGKRAKERPPRARP----------ASTSPSPGAHGRRGGP 483
Query: 862 IGVKFSRD--------RESRSPFLKPDERAPTEMAKAAPGSTKPKKTKVKAKAGAKKTKG 913
G SR SRSP K R+ + + S PKK + K G + +
Sbjct: 484 EGKSSSRSPGPHPRSWSSSRSP-SKSRSRSAEKRPHSPSRSPSPKKPLSRDKDGEGRARH 542
Query: 914 TKGKTKPSKTRKK 926
++ + ++ R +
Sbjct: 543 SEAEATRARRRSR 555
Score = 89.4 bits (220), Expect = 2e-17
Identities = 123/448 (27%), Positives = 175/448 (39%), Gaps = 53/448 (11%)
Query: 450 HAESDGEGALQVDLGE---PAPAPPAADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPA 506
H ES G + + G P+ + +DSR L K + R+ QRS S + +P+
Sbjct: 244 HTESPGRRSHRHSSGSSHSPSLSSHYSDSR-SPSRLSPKHRDEGRKTGSQRS-SGSRSPS 301
Query: 507 PAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHA 566
P+ +G + +++ +RSG A S+ + P P+ SP K + P +
Sbjct: 302 PSGGSGWGSPQRNGGSGQRSG-AHGGRPGSAHSPPDKPSSPSPRVRDKAAAAAPTPPARG 360
Query: 567 SSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPATSSSSSSR 626
S RS S+ R R GG+ R R R +RRRR RS S+S+ R
Sbjct: 361 KESPSPRSAPSSQGRG--------GRAAGGAGRRRRRRRRRRRSRS-------SASAPRR 405
Query: 627 RERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAV 686
R R R + GS + R+RS + SG G AP P P P G R +
Sbjct: 406 RGRRRPRPAPPRGSSRSLSRARSSSDSGSGRG---APGPGPEPGSERGHGGHGKRAKERP 462
Query: 687 PPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKS 746
P + T A R G KS R P P P S S S + +S
Sbjct: 463 PRARPASTSPSPGAHGR--RGGPEGKSSSRSPGPHPRSW--------SSSRSPSKSRSRS 512
Query: 747 SQKDRRRSGAASSSSSSREKGSRRKALDGGDR--DRDRDRDRDRDRSSKKARPPKESAPS 804
++K R + S S S ++ SR K +G R + + R R R RS R + +PS
Sbjct: 513 AEK---RPHSPSRSPSPKKPLSRDKDGEGRARHSEAEATRARRRSRSYSPIRKRRRDSPS 569
Query: 805 SGPP------PKPPVSSGSGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAG 858
P K P+ S SSSSSC S +S S +P S
Sbjct: 570 FMEPRRITSARKRPIPYYRPSPSSSSSCLSSDYSTRSH--------SRSPSPGHSHGSYS 621
Query: 859 LGSIGVKFSRDRESRSPFLKPDERAPTE 886
S G + SR+P R+ +E
Sbjct: 622 SRSHGTRSRTRSPSRTPSPSYHSRSSSE 649
Score = 68.9 bits (167), Expect = 3e-11
Identities = 102/454 (22%), Positives = 153/454 (33%), Gaps = 94/454 (20%)
Query: 535 SSSGTQPAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRST---RRRSRSTD 591
SSS P P + + +K G H S +RR S S+ R++ +S
Sbjct: 160 SSSSASPPP------------KKKKKKKGGHRRSRKKRRLESECSCGSSSPLRKKKKSVK 207
Query: 592 RRRGGSRRSRSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRG 651
+ R S SR KRR R RS S R+E+++ K K+ S R
Sbjct: 208 KHRRDRSDSGSRRKRRHRSRS---------SKCKRKEKNKEK-------KRPHTESPGRR 251
Query: 652 EKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLD 711
R GS +P S S DSR + P +D G
Sbjct: 252 SHRHSSGSSHSP--------SLSSHYSDSRSPSRLSPKHRD----------EGRKTGSQR 293
Query: 712 KSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRK 771
S R PSP+ S G +R G S Q+ G S+ S +K S
Sbjct: 294 SSGSRSPSPSGGS-----------GWGSPQRNGGSGQRSGAHGGRPGSAHSPPDKPSSPS 342
Query: 772 ALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSSSSSCSSRKV 831
R RD+++ A P S P P S G G ++ + R+
Sbjct: 343 P-------------RVRDKAAAAAPTPPARGKESPSPRSAPSSQGRGGRAAGGAGRRRRR 389
Query: 832 KLQ-----SKVAVLIREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDERAPTE 886
+ + S + R G PA S+ SR R S + +
Sbjct: 390 RRRRRRSRSSASAPRRRGRRRPRPAPPRGSSR------SLSRARSS----------SDSG 433
Query: 887 MAKAAPGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKKSK 946
+ APG ++ K+ K + +P+ T + G GG G+ S +
Sbjct: 434 SGRGAPGPGPEPGSERGHGGHGKRAKERPPRARPASTSPSPGAHGRRGGPEGKSSSRSPG 493
Query: 947 ADSCSQAAGTKGAEETSWSGEERAAKVPSTPPPK 980
S ++ ++ S S E+R +P PK
Sbjct: 494 PHPRSWSSSRSPSKSRSRSAEKRPHSPSRSPSPK 527
Score = 64.3 bits (155), Expect = 7e-10
Identities = 93/353 (26%), Positives = 130/353 (36%), Gaps = 49/353 (13%)
Query: 394 GEIVQPEEEPRLALSLFRPGGRAARPTPAA----SATPTAQPLPQPPAPRAPEGDDFLSL 449
G P ++P R AA PTP A S +P + P Q RA G
Sbjct: 329 GSAHSPPDKPSSPSPRVRDKAAAAAPTPPARGKESPSPRSAPSSQGRGGRAAGGAGRRRR 388
Query: 450 H------AESDGEGALQVDLGEPAPAPPAADSRWGGLDLRRKILTQRRERYRQRSPSPAP 503
+ S + P PAPP SR L++ R S AP
Sbjct: 389 RRRRRRRSRSSASAPRRRGRRRPRPAPPRGSSR---------SLSRARSSSDSGSGRGAP 439
Query: 504 APAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPG 563
P P + +R ++R A+ A++S S P + +S R PG
Sbjct: 440 GPGPEPGSERGHGGHGKRAKERPPRARPASTSPS------PGAHGRRGGPEGKSSSRSPG 493
Query: 564 SH----ASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPAT 619
H +SS + +SRSRS + SRS ++ SR+K R S AT
Sbjct: 494 PHPRSWSSSRSPSKSRSRSAEKRPHSPSRSP-----SPKKPLSRDKDGEGRARHSEAEAT 548
Query: 620 SSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAP--APPPSGSTSCGD 677
R R + R +K+++ S S E R + K P P P PS S+SC
Sbjct: 549 ---------RARRRSRSYSPIRKRRRDSPSFMEPRRITSARKRPIPYYRPSPSSSSSCLS 599
Query: 678 RD-SRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKRE 729
D S R + PS H ++ + T R +S R PSP+ S E
Sbjct: 600 SDYSTRSHSRSPSPGH--SHGSYSSRSHGTRSR-TRSPSRTPSPSYHSRSSSE 649
Score = 39.7 bits (91), Expect = 0.019
Identities = 80/384 (20%), Positives = 121/384 (31%), Gaps = 63/384 (16%)
Query: 728 REVLYDSEG-LSGEERGGKS--SQKDRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDR 784
R++L + EG L+ E+R G ++ R GA E G D D D D
Sbjct: 92 RQMLMEKEGVLTREDRPGGHIVAETPRLTEGA--------EPGLEYAPFDDDDGPVDCDC 143
Query: 785 DRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSSSSSCSSRKVKLQSKVAVLIREG 844
R + R S+ S+ PPPK G S +K +L+S+ +
Sbjct: 144 PASCYRGHRGYRTKHWSSSSASPPPKKKKKKKGGHRR-----SRKKRRLESECSCGSSSP 198
Query: 845 VSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDERAPTEMAKAAPGSTKPKKTKVKA 904
+ + G + R SRS K E+ K P + P + +
Sbjct: 199 LRKKKKSVKKHRRDRSDSGSRRKRRHRSRSSKCKRKEK---NKEKKRPHTESPGRRSHRH 255
Query: 905 KAGAKKTKGTKG----KTKPSKTRKKVRSGGGSGGSGGQVSLKKSKADSCSQAAGTKGAE 960
+G+ + PS+ K R G GS S++ S S +G +
Sbjct: 256 SSGSSHSPSLSSHYSDSRSPSRLSPKHRDEGRKTGSQRS---SGSRSPSPSGGSGWGSPQ 312
Query: 961 ETSWSGEERAA------------KVPSTPPPK-------AAPPPPALTPDSQTVDSSCKT 1001
SG+ A PS+P P+ AAP PPA +S
Sbjct: 313 RNGGSGQRSGAHGGRPGSAHSPPDKPSSPSPRVRDKAAAAAPTPPARGKES--------- 363
Query: 1002 PEVSFLPEEATEEAGVRGGAEEEEEEEEEEEEEEE---------EEEQQPATTTATSTAA 1052
P P GGA +PA +S +
Sbjct: 364 PSPRSAPSSQGRGGRAAGGAGRRRRRRRRRRRSRSSASAPRRRGRRRPRPAPPRGSSRSL 423
Query: 1053 AAPSTAPSAGSTAGDSGAEDGPAS 1076
+ ++ +GS G G P S
Sbjct: 424 SRARSSSDSGSGRGAPGPGPEPGS 447
Score = 39.7 bits (91), Expect = 0.019
Identities = 61/233 (26%), Positives = 84/233 (36%), Gaps = 22/233 (9%)
Query: 373 TAGGAALPPPLLPPGDSEIEEGEIVQPEEEP---RLALSLFRPGGRAARPTPAASATPTA 429
+ G P P PG G + +E P R A + PG R P ++ +
Sbjct: 432 SGSGRGAPGPGPEPGSERGHGGHGKRAKERPPRARPASTSPSPGAHGRRGGPEGKSSSRS 491
Query: 430 QPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGGLDLRRKILTQ 489
P PR+ S E P+P P + + G R
Sbjct: 492 PG----PHPRSWSSSRSPSKSRSRSAEKRPHSPSRSPSPKKPLSRDKDGEGRARHSEAEA 547
Query: 490 RRERYRQRSPSPA-PAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQPAPPAPAS 548
R R R RS SP + + P R S R+R +SSSS +S
Sbjct: 548 TRARRRSRSYSPIRKRRRDSPSFMEPRRITSARKRPIPYYRPSPSSSSS-------CLSS 600
Query: 549 PWDSKKHRSRDRKPG-SHASSSARR-----RSRSRSRSRSTRRRSRSTDRRRG 595
+ ++ H SR PG SH S S+R R+RS SR+ S SRS+ G
Sbjct: 601 DYSTRSH-SRSPSPGHSHGSYSSRSHGTRSRTRSPSRTPSPSYHSRSSSESGG 652
Score = 35.0 bits (79), Expect = 0.47
Identities = 36/155 (23%), Positives = 55/155 (35%), Gaps = 9/155 (5%)
Query: 149 PRLRAWRTGKTVSPQSNSSRPTCARHLTLGTGDGGPAPPPAPSSASSSPSPSPSSSSPSP 208
PR R R + P+ +S + AR + +G G AP P P S +
Sbjct: 403 PRRRGRRRPRPAPPRGSSRSLSRARSSS-DSGSGRGAPGPGPEPGSERGHGGHGKRAKER 461
Query: 209 PPPPPPPAPPAPPAPRFDIYDPFHPTDEAYSPPPAPEQKYDPFEPTGS-------NPSSS 261
PP P + P P + SP P P P+ S P S
Sbjct: 462 PPRARPASTSPSPGAHGRRGGP-EGKSSSRSPGPHPRSWSSSRSPSKSRSRSAEKRPHSP 520
Query: 262 AGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISR 296
+ +PSP++ +++ E E E ++ SR
Sbjct: 521 SRSPSPKKPLSRDKDGEGRARHSEAEATRARRRSR 555
Score = 31.6 bits (70), Expect = 5.2
Identities = 14/34 (41%), Positives = 15/34 (44%), Gaps = 2/34 (5%)
Query: 1280 HGRKPGDPPGPPRPPKEPGP--PDKGGPGLPLPP 1311
HG +PG PP P P P DK P PP
Sbjct: 324 HGGRPGSAHSPPDKPSSPSPRVRDKAAAAAPTPP 357
>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
sapiens]
Length = 1130
Score = 91.3 bits (225), Expect = 6e-18
Identities = 103/380 (27%), Positives = 132/380 (34%), Gaps = 102/380 (26%)
Query: 121 ESEDMLELVAEVRIGDRDPIPLPVPSLLPRLRAWRTGKTVSPQSNSSRPTCARHLTLGTG 180
+S+D + +V E P+P P PS G T P + + PT
Sbjct: 783 DSDDSVVIVPE----GLPPLPPPPPS----------GATPPPIAPTGPPT---------- 818
Query: 181 DGGPAPPPAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAP---PAPRFDIYDPFHPTDEA 237
A PP P A P P++ P PPPPPPPP P P P P+
Sbjct: 819 ----ASPPVP--AKEEPEELPAAPGPLPPPPPPPPPVPGPVTLPPPQL-----VPEGTPG 867
Query: 238 YSPPPAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRI 297
PPA E+ S+ EEEEEEEEEEE+ EE+EE+EE +
Sbjct: 868 GGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEE- 926
Query: 298 SETLAGIYDDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVVGT 357
++ ++F +E + + +
Sbjct: 927 --------EEEEFEEEFEEEEGELEEEEEEE---------------------------DE 951
Query: 358 EAEACREGKVSVEVVTAGG----AALPPPLLPPGDSEIEEGEIVQPEEEPR--LALSLFR 411
E E E +E TAGG A PPP LPP E VQPE EP L L +
Sbjct: 952 EEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEE 1011
Query: 412 PG-----GRAARPTPAASA------------TPTAQPLPQPPAPRAPEGDDFLSLHAESD 454
PG G PT A A +P A P PQ P L D
Sbjct: 1012 PGTEEERGADTAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETED 1071
Query: 455 GEGALQVDLGEPAPAPPAAD 474
G +Q P P PA +
Sbjct: 1072 GSDKVQ-----PPPETPAEE 1086
Score = 53.1 bits (126), Expect = 2e-06
Identities = 36/80 (45%), Positives = 39/80 (48%), Gaps = 7/80 (8%)
Query: 967 EERAAKVPSTPPPKAAPPP---PALTPDSQTVDSSCKTPEVSFLP--EEATEEAGVRGGA 1021
EE A PPP PPP P P Q V TP P EE +
Sbjct: 830 EELPAAPGPLPPPPPPPPPVPGPVTLPPPQLVPEG--TPGGGGPPALEEDLTVININSSD 887
Query: 1022 EEEEEEEEEEEEEEEEEEQQ 1041
EEEEEEEEEEEEEEEEEE++
Sbjct: 888 EEEEEEEEEEEEEEEEEEEE 907
Score = 49.7 bits (117), Expect = 2e-05
Identities = 29/68 (42%), Positives = 34/68 (50%)
Query: 974 PSTPPPKAAPPPPALTPDSQTVDSSCKTPEVSFLPEEATEEAGVRGGAEEEEEEEEEEEE 1033
P PPP P P L P + + L E+ T EEEEEEEEEEEE
Sbjct: 841 PPPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEE 900
Query: 1034 EEEEEEQQ 1041
EEEEEE++
Sbjct: 901 EEEEEEEE 908
Score = 44.3 bits (103), Expect = 8e-04
Identities = 29/74 (39%), Positives = 37/74 (50%), Gaps = 9/74 (12%)
Query: 977 PPPKAAPP-------PPALTPDSQTVDSSCKTPEVSFLPEEATEEAGVRGGAEEEEEEEE 1029
PPP+ P PPAL D ++ + E EE EE E+ EEEEE
Sbjct: 856 PPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEE 915
Query: 1030 EEEE--EEEEEEQQ 1041
+EEE EEEEEE++
Sbjct: 916 DEEEYFEEEEEEEE 929
Score = 43.5 bits (101), Expect = 0.001
Identities = 97/449 (21%), Positives = 126/449 (28%), Gaps = 123/449 (27%)
Query: 162 PQSNSSRPTCARHLTLGTGDGGPAPP---PAPSSASSSPSPSPSSSSPSPPPPPPPPAPP 218
P + PT A HL L PP P P + + + P + PPP PP
Sbjct: 696 PSARPGPPTTANHLGLSVPGLVSVPPRLLPGPENHRAGSNEDPILAPSGTPPPTIPPDET 755
Query: 219 ---APPAPRFDIYDPFHPTDEAYSP---------------PPAPEQKYDPFEPTGSNPSS 260
P P F YD +D S PP P P P+G+ P
Sbjct: 756 FGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLPPLP-----PPPPSGATPPP 810
Query: 261 SAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISETLAGIYDDNSLSQDFPGDESP 320
A T P +EE EE PG P
Sbjct: 811 IAPTGPPTASPPVPAKEEPEELPAA-----------------------------PGPLPP 841
Query: 321 RPDAQPTQPTPAPGTPPQV--DSTRADG---AMRRRVFVVGTEAEACREGKVSVEVVTAG 375
P P P P PPQ+ + T G A+ + V+ + E + E
Sbjct: 842 PPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEE 901
Query: 376 GAALPPPLLPPGDS--------------------EIEEGEIVQPEEEPRLA--------- 406
+ E EEGE+ + EEE
Sbjct: 902 EEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVE 961
Query: 407 -LSLFRPGGRAARPTPAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGE 465
L GG P P A P P+ P PE + L E + G + +
Sbjct: 962 DLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGAD 1021
Query: 466 PAP--APPAADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAP-----AAAAGPPTRKK 518
AP AP A S + + SPA P P + PPT +
Sbjct: 1022 TAPTLAPEALPS---------------QGEVEREGESPAAGPPPQELVEEEPSAPPTLLE 1066
Query: 519 SRRERKRSGEAKEAASSSSGTQPAPPAPA 547
+E S QP P PA
Sbjct: 1067 -----------EETEDGSDKVQPPPETPA 1084
Score = 43.1 bits (100), Expect = 0.002
Identities = 75/329 (22%), Positives = 103/329 (31%), Gaps = 78/329 (23%)
Query: 139 PIPLPVPSLLPRLRAWRTGKT-----VSPQSNSSRPTCARHLTLGTGDGGPAPPPAPSSA 193
P P P L L+A+ G+ VS + + TCA L P P P+
Sbjct: 590 PSPRCPPPLACALQAFSLGQREDSLEVSSFCSEALVTCA---ALTHPRVPPLQPMGPTCP 646
Query: 194 SSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEAYSPPPAPEQKYDPFEP 253
+ +P P P + SP PP PP P P P P
Sbjct: 647 TPAPVPPPEAPSPFRAPPFHPPGP---------------MPSVGSMPSAGPMPSAGPMPS 691
Query: 254 TGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISETLAGIYDDNSLSQD 313
G PS+ G P+ + + + ++ G+ + +
Sbjct: 692 AGPVPSARPGPPT--------------------------TANHLGLSVPGLV--SVPPRL 723
Query: 314 FPGDESPRPDAQPTQPTPAPGTPPQV---DSTRADGAMRRRVFVVGTEAEAC-------R 363
PG E+ R + GTPP D T G + R FV + EA
Sbjct: 724 LPGPENHRAGSNEDPILAPSGTPPPTIPPDET-FGGRVPRPAFVHYDKEEASDVEISLES 782
Query: 364 EGKVSVEVVTAG---------GAALPPPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGG 414
+ SV +V G A PPP+ P G V +EEP P
Sbjct: 783 DSDDSVVIVPEGLPPLPPPPPSGATPPPIAPTGPPTASPP--VPAKEEPEEL-----PAA 835
Query: 415 RAARPTPAASATPTAQPLPQPPAPRAPEG 443
P P P P+ PP PEG
Sbjct: 836 PGPLPPPPPPPPPVPGPVTLPPPQLVPEG 864
Score = 42.0 bits (97), Expect = 0.004
Identities = 31/87 (35%), Positives = 36/87 (41%), Gaps = 16/87 (18%)
Query: 1003 EVSFLPEEATEEAGVRGGAEEEEEEEEEEEEEEEEEEQQPATTTATSTAAAAPSTAPSAG 1062
E + EE EE EEEE E EEEEEEE+EEE++
Sbjct: 917 EEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEE-----------ELEEVEDLEF 965
Query: 1063 STAGDSGAEDGPASRVSQLPTLPPPMP 1089
TAG E P PTLPP +P
Sbjct: 966 GTAGGEVEEGAPPP-----PTLPPALP 987
Score = 41.6 bits (96), Expect = 0.005
Identities = 31/92 (33%), Positives = 38/92 (41%), Gaps = 24/92 (26%)
Query: 974 PSTPPPKAAP---PPPALTPDSQ-------TVDSSCKTPEVSFLPEEATEEAGVRGGAEE 1023
P PPP P PPP L P+ ++ ++ EE EE EE
Sbjct: 843 PPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEE 902
Query: 1024 EEEEEE--------------EEEEEEEEEEQQ 1041
EEEEEE EEEEEEEE E++
Sbjct: 903 EEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEE 934
Score = 40.4 bits (93), Expect = 0.011
Identities = 61/268 (22%), Positives = 84/268 (31%), Gaps = 58/268 (21%)
Query: 331 PAPGTPPQVDSTRADGAMRRRVFVVGTEAEACREGKVSVE-VVTAGGAALP--PPLLPPG 387
P+P PP + A + F +G ++ E +VT P PPL P G
Sbjct: 590 PSPRCPPPL-------ACALQAFSLGQREDSLEVSSFCSEALVTCAALTHPRVPPLQPMG 642
Query: 388 DSEIEEGEIVQPEEEPRLALSLFRPGG--------RAARPTPAASATPTAQPLPQPPAPR 439
+ + PE F P G +A P P+A P+A P+P P
Sbjct: 643 PTCPTPAPVPPPEAPSPFRAPPFHPPGPMPSVGSMPSAGPMPSAGPMPSAGPVPS-ARPG 701
Query: 440 APEGDDFLSL------------------HAESDGEGALQVDLGEPAPAPPAADSRWGGLD 481
P + L L H E + G P P P D +GG
Sbjct: 702 PPTTANHLGLSVPGLVSVPPRLLPGPENHRAGSNEDPILAPSGTPPPTIP-PDETFGGRV 760
Query: 482 LRRKILTQRRERYRQRSPS-----------------PAPAPAPAAAAGP---PTRKKSRR 521
R + +E S P P P P+ A P PT +
Sbjct: 761 PRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLPPLPPPPPSGATPPPIAPTGPPTAS 820
Query: 522 ERKRSGEAKEAASSSSGTQPAPPAPASP 549
+ E E ++ G P PP P P
Sbjct: 821 PPVPAKEEPEELPAAPGPLPPPPPPPPP 848
Score = 32.7 bits (73), Expect = 2.3
Identities = 51/234 (21%), Positives = 85/234 (36%), Gaps = 26/234 (11%)
Query: 1067 DSGAEDGPASRVSQLPTLPPPMPWNLPAGVDCTTSGVLALTALLFKMEEANLASRAKAQE 1126
+S ++D LP LPPP P T A + K E E
Sbjct: 781 ESDSDDSVVIVPEGLPPLPPPPPSGATPPPIAPTGPPTASPPVPAKEE----------PE 830
Query: 1127 LIQATNQILSHRKPPSSLGMTPAPVPTSLGLPPGPSSYLLPGSLPLGGCGSTPPTPTGLA 1186
+ A L PP P PVP + LPP L+P P GG PP
Sbjct: 831 ELPAAPGPLPPPPPP------PPPVPGPVTLPP---PQLVPEGTPGGG---GPPALEEDL 878
Query: 1187 ATSDKREGSSSSEGRGDTDKYLKKLHTQERAVEEVKLAIKPYYQKKDITKEEYKDILRKA 1246
+ E + ++ ++ +E EE + + Y+++++ +EE+++ +
Sbjct: 879 TVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEE 938
Query: 1247 VHKICHSKSGEINPVKVSNLVRAYVQRYRYFRKHGR-KPGDPPGPPRPPKEPGP 1299
++ + E + + L V+ + G + G PP P PP P P
Sbjct: 939 EGEL-EEEEEEEDEEEEEELEE--VEDLEFGTAGGEVEEGAPPPPTLPPALPPP 989
Score = 32.0 bits (71), Expect = 4.0
Identities = 30/97 (30%), Positives = 38/97 (39%), Gaps = 18/97 (18%)
Query: 967 EERAAKVPSTPPPKAAPP----------PPALTPDSQTVDSSCKTPEVSFLPEEATEEAG 1016
EER A T P+A P P A P + V+ P L EE TE+
Sbjct: 1016 EERGADTAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPT--LLEEETEDGS 1073
Query: 1017 VR------GGAEEEEEEEEEEEEEEEEEEQQPATTTA 1047
+ AEEE E E E E +E+E+ A A
Sbjct: 1074 DKVQPPPETPAEEEMETETEAEALQEKEQDDTAAMLA 1110
>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
Length = 494
Score = 89.4 bits (220), Expect = 2e-17
Identities = 109/427 (25%), Positives = 161/427 (37%), Gaps = 69/427 (16%)
Query: 511 AGPPTRKKSRRERKRSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHASSSA 570
AG T + + RK G E S S + + + +K R + KPGS
Sbjct: 127 AGEVTYADAHKGRKNEGVI-EFVSYSDMKRALEKLDGTEVNGRKIRLVEDKPGSRRR--- 182
Query: 571 RRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPATSSSSSSRRERH 630
R SRSRS SRS RSRSR R+ R RS S + SS S R R
Sbjct: 183 RSYSRSRSHSRS----------------RSRSRHSRKSRSRSGS----SKSSHSKSRSRS 222
Query: 631 RGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPSI 690
R G + K RSRS+ RS ++P+ S S S G S+ + I
Sbjct: 223 R-----SGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKI 277
Query: 691 QDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQKD 750
Q+ VG+ P+ SP+ S + E EE+ G S+
Sbjct: 278 QN-----------NDNVGK-----PKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGR 321
Query: 751 RRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPPK 810
+ S S SR K GG R R R R + +D+ + R +ES S K
Sbjct: 322 SQEKSLRQSRSRSRSK--------GGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSK 373
Query: 811 PPVSSGSGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFSRDR 870
S GS S + SS+K K + R S + ++ A + S R
Sbjct: 374 SERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSE--------SSQR 425
Query: 871 ESRSPFLKPDERAPTEMAKAAPGSTK---PKKTKVKAKAGAKKTKGTKGKTK-----PSK 922
E R T + +K P +++ ++K+ +K +K +++ PS+
Sbjct: 426 EGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSASRSPSR 485
Query: 923 TRKKVRS 929
+R + S
Sbjct: 486 SRSRSHS 492
Score = 77.4 bits (189), Expect = 8e-14
Identities = 88/360 (24%), Positives = 145/360 (40%), Gaps = 53/360 (14%)
Query: 483 RRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQPA 542
RR+ ++ R R RS S + SR+ R RSG +K + S S
Sbjct: 181 RRRSYSRSRSHSRSRSRS----------------RHSRKSRSRSGSSKSSHSKS------ 218
Query: 543 PPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRS 602
RSR R S + S ++ RSRS+SRSRS + +SRS + + SR +
Sbjct: 219 -------------RSRSR---SGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSA 262
Query: 603 REKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKA 662
+ R + + A + + + R +H+ S+ + + R EKR ++
Sbjct: 263 GKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRS 322
Query: 663 PAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAP 722
+ S S S SR R +D KR ++S R S +
Sbjct: 323 QEKSLRQSRSRSRSKGGSRSRSRSRSKSKD---------KRKGRKRSREESRSRSRSRSK 373
Query: 723 AS-SPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSS---SREKGSRRKALDGGDR 778
+ S KR DS+ S +++ + + + + RS + S S ++ + S+R+ +
Sbjct: 374 SERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESEN 433
Query: 779 DRDRDRDRDRDRSSKKARP--PKESAPSSGPPPKPPVSSGSGSSSSSSSCSSRKVKLQSK 836
R R RS+ K++P P ES S K S S S S+S S S + + S+
Sbjct: 434 AGTNQETRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRSRSHSR 493
Score = 70.9 bits (172), Expect = 8e-12
Identities = 74/318 (23%), Positives = 120/318 (37%), Gaps = 21/318 (6%)
Query: 767 GSRRKALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSSSSSC 826
GSRR+ R R R R R R S+K+R S+ SS + SGS S S S S
Sbjct: 178 GSRRRR--SYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSR 235
Query: 827 SSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFL-------KP 879
S + + + + S +P+K+ + + S G S+ ++ + KP
Sbjct: 236 SQSRSRSKKE---------KSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKP 286
Query: 880 DERAPTEMAKAAPGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQ 939
R+P+ + ++ ++ +V+ + ++G + ++R + RS GGS
Sbjct: 287 KSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRS 346
Query: 940 VSLKKSKADSCSQAAGTKGAEETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTVDSSC 999
S K K ++ + S S ER+ K S KA D+ S
Sbjct: 347 RSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRS 406
Query: 1000 KTPEVSFLPEEATEEAGVRGGAEEEEEEEEEEEEEEEEEEQQPATTTATSTAAAAPSTAP 1059
+ VS E A E+ R G E E +E + S + S +
Sbjct: 407 PSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESR---SRSK 463
Query: 1060 SAGSTAGDSGAEDGPASR 1077
SA T S + ASR
Sbjct: 464 SASKTRSRSKSRSRSASR 481
Score = 43.1 bits (100), Expect = 0.002
Identities = 35/113 (30%), Positives = 54/113 (47%), Gaps = 7/113 (6%)
Query: 474 DSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAA 533
DS+ G ++K + +R + RSPS + + A ++++ R E + +G +E
Sbjct: 385 DSKAGSSKKKKK---EDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETR 441
Query: 534 SSS-SGTQPAPPAPASPWDSKKHRSRDRKPGSHASSSARR---RSRSRSRSRS 582
S S S ++ P P+ K S+ R S SA R RSRSRS SRS
Sbjct: 442 SRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRSRSHSRS 494
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c [Homo
sapiens]
Length = 958
Score = 87.8 bits (216), Expect = 6e-17
Identities = 176/861 (20%), Positives = 279/861 (32%), Gaps = 110/861 (12%)
Query: 250 PFEPTGSNPSSSAGTPSPEEEEEEEEE----EEEEEEDEEEEEGLSQSISRISETLAGIY 305
P TG ++ SP + E E EEE G + +S A
Sbjct: 140 PHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSS 199
Query: 306 DDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAEACREG 365
+++ S D +P +P Q + + + + +A A G
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPA----------------PG 243
Query: 366 KVSVEVVTAGGAALPPPLL---PPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPTPA 422
KV G ALPP P +SE E EE P S + + + A
Sbjct: 244 KVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAA 303
Query: 423 ---ASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGG 479
A TP P PP + E D E + + + + PAA +
Sbjct: 304 SAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSE-ESSDSEEETPAAKALLQA 362
Query: 480 LDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGT 539
+ + SP APAP GP K +R+ ++ S S
Sbjct: 363 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEE 422
Query: 540 QPAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRR 599
PA P+ + S K ++ ++ + + + D R
Sbjct: 423 APAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEES 482
Query: 600 SRSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGS 659
RE + P S G G G K + + G
Sbjct: 483 DSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWE 542
Query: 660 EKAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPS 719
E + + + S S+ G VP ++ + L I + K P+
Sbjct: 543 EDSESSSEESSDSSD---------GEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAG 593
Query: 720 PAPASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSRE--KGSRRKALDGGD 777
P + + +SE S EE S D + AA +++ ++ K + KA
Sbjct: 594 PVAVQVKAEKPMDNSE--SSEE---SSDSADSEEAPAAMTAAQAKPALKIPQTKACP--- 645
Query: 778 RDRDRDRDRDRDRSSKKARP-------PKESAPSSGPPPKPPVSSG-----SGSSSSSSS 825
+ +S K P P+++ ++ P P +G + SSSS
Sbjct: 646 -------KKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEE 698
Query: 826 CSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDERAPT 885
S + K V V + V K A+ GS+G + +P L
Sbjct: 699 SDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLG-------QGTAPVL-------- 743
Query: 886 EMAKAAPGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQV--SLK 943
PG T P T+VKA+ K + S++ ++ + S QV S+K
Sbjct: 744 ------PGKTGPTVTQVKAE-----------KQEDSESSEEESDSEEAAASPAQVKTSVK 786
Query: 944 KSKADSCSQAAGTKGAEET-SWSGEERAAKVPSTPPPKAAPPPPALTPDSQTVDSSCKTP 1002
K++A + AA A+ T S G+ A + + PP P + TV +
Sbjct: 787 KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 846
Query: 1003 EVSFLPEEATEEAGVRGGAEEEEEEEEEEEEEEEEE---EQQPATTTATSTAAAAPS--- 1056
S AT G E+ EEE + EEE E + +P+ T AA AP+
Sbjct: 847 VPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKES 906
Query: 1057 ----TAPSAGSTAGDSGAEDG 1073
AP+ G S A+ G
Sbjct: 907 PRKGAAPTPPGKTGPSAAQAG 927
Score = 86.3 bits (212), Expect = 2e-16
Identities = 216/1015 (21%), Positives = 341/1015 (33%), Gaps = 141/1015 (13%)
Query: 219 APPAPRFDIYDPFHPTDEAYSPPPAPEQKYDPFEPTG-SNPSSSAGTPSPEEEEEEEEEE 277
A P DIY + T E A E + T S+P S++ E
Sbjct: 41 AQPVTLLDIYTHWQQTSELGRKRKAEEDAALQAKKTRVSDPISTS------------ESS 88
Query: 278 EEEEEDEEEEEGLSQSISRISETLAGIYDDNSLSQDFPGDESPRPDAQPTQPTPAPG-TP 336
EEEEE E E + ++ + ++ G +S+ + + + P PA G T
Sbjct: 89 EEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTV 148
Query: 337 PQVDSTRADGAMRRRVFVVGTEAEACREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEI 396
+ S ++ +E EG V A GAA P ++ G ++ +
Sbjct: 149 ANLLSGKSPRKSAEPSANTTLVSETEEEGSVP-----AFGAAAKPGMVSAGQADSSSEDT 203
Query: 397 VQPEEEPRLALSLFRPGGRAARPTPAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGE 456
+E + G + +P +++ + + P A AP G+
Sbjct: 204 SSSSDETDVE------GKPSVKPAQVKASSVSTKESPARKAAPAPG----------KVGD 247
Query: 457 GALQVDLGEPAPAPPAADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTR 516
QV G PA R K + E + S S APA TR
Sbjct: 248 VTPQVKGGALPPAK------------RAKKPEEESESSEEGSESEEEAPAG-------TR 288
Query: 517 KKSRRERK----RSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHASSSARR 572
+ + K R+ A + G PAPP A S+ ++ KP + SS+
Sbjct: 289 SQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQ---TKAGKPEEDSESSSEE 345
Query: 573 RSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPATSSSSSSRRERHRG 632
S S + + + ++ + + S + R+ A+P P + + + +
Sbjct: 346 SSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQ--- 402
Query: 633 KHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQD 692
+ K+++ S+S E+ D E+APA A P + R A P+
Sbjct: 403 -------AGKREEDSQSSSEE--SDSEEEAPAQAKPSGKAPQV-------RAASAPA--- 443
Query: 693 LTDHDLFAIKRTITVGRLDKSDPR-GPSPAPASSPKREVLYDSEGLSGEERGGKSSQKDR 751
K PR G +PAP G E+ S + D
Sbjct: 444 -------------------KESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDS 484
Query: 752 RRSG-AASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPPK 810
R AA +++ + G + K P SA
Sbjct: 485 DREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEED 544
Query: 811 PPVSSGSGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAAS-AGLGSIGVKFSRD 869
SS S SS + Q K I + +++PAK AG ++ VK +
Sbjct: 545 SESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKP 604
Query: 870 RESRSPFLKPDERAPTEMAKAA--PGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKV 927
++ + + A +E A AA KP + KA KKT T K + R
Sbjct: 605 MDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTN-TTASAKVAPVRVGT 663
Query: 928 RSGGGSGGSGGQVSLKKSKADSCSQAAGTKGAEETSWSGEERAAKVPSTPPPKAAPPPPA 987
++ +G + + A + A + E S S EE+ + K+
Sbjct: 664 QAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQ 723
Query: 988 LTPDSQTVDSSCKTPEVSFLPEEATEEAGVRGGAEEEEEEEEEEEEEEEEEEQQPATTTA 1047
+ S V S LP + T + AE++E+ E EEE + EE
Sbjct: 724 VKAASVPVKGSLGQGTAPVLPGK-TGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVK 782
Query: 1048 TST------AAAAPSTAPSAGSTAGDSGAEDGPASRVSQL--PTLPPPM--PWNL----- 1092
TS A A + APSA T G A++ Q + PP+ P N
Sbjct: 783 TSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLAR 842
Query: 1093 -PAGVDCTTSGVLALTALLFKMEEANLASRAKAQELIQATNQILSHRKPPSSLGMTPAPV 1151
PA V V EE + +S ++ +A + L+ KP A
Sbjct: 843 GPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA--ETLAQVKPSGKTHQIRA-- 898
Query: 1152 PTSLGLPPGPSSYLLPGSLPLGGCGSTPPTPTG-LAATSDKREGSSSSEGRGDTD 1205
L P S P G TPP TG AA + K++ S SS D+D
Sbjct: 899 ----ALAPAKES-------PRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSD 942
Score = 67.4 bits (163), Expect = 9e-11
Identities = 163/752 (21%), Positives = 249/752 (33%), Gaps = 148/752 (19%)
Query: 552 SKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRR 611
+KK R D P S + SS +++T R + + G S +EK +
Sbjct: 73 AKKTRVSD--PISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETE 130
Query: 612 SAS------PPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAP 665
A P PAT + ++ G +K S + E+ P
Sbjct: 131 KAGKTGNSMPHPATGKTVANLLS----------GKSPRKSAEPSANTTLVSETEEEGSVP 180
Query: 666 A---PPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAP 722
A G S G DS S D TD + + V S P+
Sbjct: 181 AFGAAAKPGMVSAGQADSSSEDT--SSSSDETDVEGKPSVKPAQVKASSVSTKESPARKA 238
Query: 723 ASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDRDR 782
A +P + ++ + +GG R + S SS S +A G R +
Sbjct: 239 APAPGKV-----GDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAG---TRSQ 290
Query: 783 DRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSG--------------SGSSSSSSSCSS 828
+ ++ + A P + P G P PP +G S SSS SS S
Sbjct: 291 VKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE 350
Query: 829 R-----KVKLQSKVAVLIREGVSSTTPAKD-----AASAGLGSIGVKFSRDRESRSPFLK 878
K LQ+K + + +++ PAK+ AA A G G ++ + +
Sbjct: 351 EETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDS 410
Query: 879 PDERAPTEMAKAAPGSTKP--KKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGS 936
++ + AP KP K +V+A + K KG P+ RK +G +
Sbjct: 411 QSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAA-PAPPRK-------TGPA 462
Query: 937 GGQVSLKKSKADSCS---------QAAGTKGAEETSWSGEERAAKVPST----------- 976
QV + K + DS S +A A + G+ K ST
Sbjct: 463 AAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAG 522
Query: 977 --PPPKAAPPPPALTPDSQTVDSSCKTPEVSFL--------------------------- 1007
PP K P P+ DS + E S
Sbjct: 523 PVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTS 582
Query: 1008 -----PEEATEEAGVRGGAEE--EEEEEEEEEEEEEEEEQQPATTTATSTAAAA--PSTA 1058
P + V+ AE+ + E EE + + E+ PA TA A P T
Sbjct: 583 SPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTK 642
Query: 1059 PSAGSTAGDSGAEDGPASRVSQLPTLPPPMPWNLPAGVDCTTSGVLALTALLFKMEEANL 1118
T + A+ P +Q P PAG +G A E+++
Sbjct: 643 ACPKKTNTTASAKVAPVRVGTQAPRKAGTA--TSPAGSSPAVAGGTQRPA-----EDSSS 695
Query: 1119 ASRAKAQE----LIQATNQILSHRKPPSSLGMTPAPVPTSLGLPPGPSSYLLPGSLPLGG 1174
+ + ++E L Q S K + PV SLG P +LPG
Sbjct: 696 SEESDSEEEKTGLAVTVGQAKSVGKG-LQVKAASVPVKGSLGQGTAP---VLPGK----- 746
Query: 1175 CGSTPPTPTGLAATSDKREGSSSSEGRGDTDK 1206
T PT T + A +K+E S SSE D+++
Sbjct: 747 ---TGPTVTQVKA--EKQEDSESSEEESDSEE 773
Score = 58.9 bits (141), Expect = 3e-08
Identities = 132/686 (19%), Positives = 210/686 (30%), Gaps = 108/686 (15%)
Query: 184 PAPP-PAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEA-YSPP 241
PAPP A + AS + + P S S P A T + +
Sbjct: 317 PAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 376
Query: 242 PAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISETL 301
PA E P + A + + EE+ + EE D EEE S + +
Sbjct: 377 PAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQV 436
Query: 302 AGIYDDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAEA 361
+ P ESPR A P P QV + + R +
Sbjct: 437 R--------AASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSR----------SS 478
Query: 362 CREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPTP 421
E E + A AA PL G S P+ +P + + P G+ A P P
Sbjct: 479 SEESDSDREALAAMNAAQVKPL---GKS---------PQVKPASTMGM-GPLGKGAGPVP 525
Query: 422 AASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGGLD 481
P P + E + S + +G + P PA + G +
Sbjct: 526 PGKVGPAT---PSAQVGKWEEDSESSSEESSDSSDGEV------PTAVAPAQEKSLGNI- 575
Query: 482 LRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQP 541
Q P+ +PA P AGP + + + E+ E +S S+ ++
Sbjct: 576 -------------LQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEE 622
Query: 542 APPA---------------PASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRR 586
AP A A P + S P + + R+ + S + S+
Sbjct: 623 APAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAV 682
Query: 587 SRSTDRRRGGSRRSRSREKRRRR-----------------RRSASPPPATSSSSSSRRER 629
+ T R S S + + + A+ P S
Sbjct: 683 AGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPV 742
Query: 630 HRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPS 689
GK K +K+ S + D E A +PA + S + A PS
Sbjct: 743 LPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKT-SVKKTQAKANPAAARAPS 801
Query: 690 IQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQK 749
+ + A + +T K P +P+ + S G +
Sbjct: 802 AKG----TISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATA 857
Query: 750 DRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPP 809
+ ++G S SS E+ + + + + + + A P + +P G P
Sbjct: 858 AQAQTGPEEDSGSSEEESDSEEEAE----TLAQVKPSGKTHQIRAALAPAKESPRKGAAP 913
Query: 810 KPPVSSG-----------SGSSSSSS 824
PP +G SGSSS S
Sbjct: 914 TPPGKTGPSAAQAGKQDDSGSSSEES 939
Score = 55.8 bits (133), Expect = 3e-07
Identities = 109/475 (22%), Positives = 161/475 (33%), Gaps = 79/475 (16%)
Query: 765 EKGSRRKALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSSSS 824
E G +RKA + + R D +S+ + +E A + P ++S + S +
Sbjct: 58 ELGRKRKAEEDAALQAKKTRVSDPISTSESSEE-EEEAEAETAKATPRLASTNSSVLGAD 116
Query: 825 SCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGS-IGVKFSRDRESRSPFLKPDER- 882
SS K K +++ + G S PA A L S + S + + + + E
Sbjct: 117 LPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEE 176
Query: 883 --APTEMAKAAPG--------------STKPKKTKVKAKAGAK--KTKGTKGKTKPSKTR 924
P A A PG S+ +T V+ K K + K + TK S R
Sbjct: 177 GSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPAR 236
Query: 925 KKVRSGGGSGGSGGQVS---------LKKSKADSCSQAAGTKGAEETSWSGEERAAKVPS 975
K + G G QV KK + +S S G++ EE +
Sbjct: 237 KAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEK 296
Query: 976 TPPPKAAPPPPALTPDSQTVDSSCKTPEVSFLPEEATEEAGVRGGAEEEEEEEEEEEEEE 1035
+AA P TP + P +A A + EE+ E EE
Sbjct: 297 ILQVRAASAPAKGTPGKGATPAP---------PGKAGAVASQTKAGKPEEDSESSSEESS 347
Query: 1036 EEEEQQPATTTATSTAAAAPSTAPSAGSTAGDSGAEDGPASRVSQLPTLPPPMPWNLPAG 1095
+ EE+ P AA A A ++G T+ GA PA + P P PA
Sbjct: 348 DSEEETP--------AAKALLQAKASGKTS-QVGAASAPAKESPRKGAAPAPPGKTGPA- 397
Query: 1096 VDCTTSGVLALTALLFKMEEANLASRAKAQELIQATNQILSHRKPPSSLGMTPAPVPTSL 1155
A K EE + +S ++ +A Q K P + AP S
Sbjct: 398 ---------VAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAP-QVRAASAPAKES- 446
Query: 1156 GLPPGPSSYLLPGSLPLGGCGSTPPTPTGLAA----TSDKREGSSSSEGRGDTDK 1206
P G PP TG AA + E S SS D+D+
Sbjct: 447 ---------------PRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDR 486
Score = 50.4 bits (119), Expect = 1e-05
Identities = 89/386 (23%), Positives = 141/386 (36%), Gaps = 47/386 (12%)
Query: 185 APPPAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEAYSPPP-- 242
A P +S SS S + S +P A PA P+ T + P
Sbjct: 601 AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR 660
Query: 243 ----APEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDE--EEEEGLSQSISR 296
AP + P GS+P+ + GT P E+ EE + EEE G ++S+ +
Sbjct: 661 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK 720
Query: 297 -ISETLAGIYDDNSLSQD----FPGDESPR-PDAQPTQPTPAPGTPPQVDSTRADGAMRR 350
+ A + SL Q PG P + + + + + DS A + +
Sbjct: 721 GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 780
Query: 351 -RVFVVGTEAEACREGKVSVEVVTAGGAALPPPLLPPGDSEIEE---GEIVQPEEEPRLA 406
+ V T+A+A + +A G P + ++ ++ ++ P P+ +
Sbjct: 781 VKTSVKKTQAKA---NPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNS 837
Query: 407 LSLFRPGGRAARPTPAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEP 466
L R G A+ P+ + AQ A PE +D S ESD E + L +
Sbjct: 838 TVLAR--GPASVPSVGKAVATAAQ------AQTGPE-EDSGSSEEESDSEEEAET-LAQV 887
Query: 467 APAPPAADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRS 526
P+ G R L +E SP AP P GP + +++ S
Sbjct: 888 KPS--------GKTHQIRAALAPAKE-----SPRKGAAPTPPGKTGPSAAQAGKQD--DS 932
Query: 527 GEAKEAASSSSGTQPAPPAPASPWDS 552
G + E S S G PA A +S
Sbjct: 933 GSSSE-ESDSDGEAPAAVTSAQDQES 957
>gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]
Length = 1682
Score = 85.5 bits (210), Expect = 3e-16
Identities = 168/695 (24%), Positives = 226/695 (32%), Gaps = 201/695 (28%)
Query: 106 PPDTWVPSRLDLRPGESEDMLELVAEVRIGDRDPIPLPVPSLLPRLRAWRTGKTVSPQSN 165
PP W+ E ++LE E+ G P P P P LP R G P S
Sbjct: 481 PPPAWLKGPACRAAREDGEILE---ELFFGTEGP-PRPAPPPLPH----REGFLGPPASR 532
Query: 166 SSRPTCARHLTLGTGDGGPAPPPAPSSASSSPSPSPSSSSPS------------------ 207
S T H P PP P+++SS+ + SSSP+
Sbjct: 533 FSVGTQDSHT--------PPTPPTPTTSSSNSNSGSHSSSPAGPVSFPPPPYLARSIDPL 584
Query: 208 PPPPPP----------------PPAPPA------------PPAPRFDIYDPFHPTDEAYS 239
P PP P PPAPP+ P +PR + P P +
Sbjct: 585 PRPPSPAQNPQDPPLVPLTLALPPAPPSSCHQNTSGSFRRPESPRPRVSFPKTP-EVGPG 643
Query: 240 PPPAPEQKYDPFEPTGSNPSSSAG------TPSPEEEEEEEEEEEEEEEDEEEEEGLSQS 293
PPP P K P G + G P+P E++ EE E + D GL+
Sbjct: 644 PPPGPLSKAPQPVPPGVGELPARGPRLFDFPPTPLEDQFEEPAEFKILPD-----GLANI 698
Query: 294 ISRISETL----------AGIYDDNSLSQDFPGDESPRP-DAQPTQPTPAPGTPPQVDST 342
+ + E++ AG+ L + F +SP P D PT PA +T
Sbjct: 699 MKMLDESIRKEEEQQQHEAGVAPQPPLKEPFASLQSPFPTDTAPTTTAPAVAVTTTTTTT 758
Query: 343 RADGAMRRRVFVVGTEAEACREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEIVQPEEE 402
A T+ E + PPP LPP
Sbjct: 759 TTTTA---------TQEEEKK----------------PPPALPP---------------- 777
Query: 403 PRLALSLFRPGGRAARPTPAASATPTAQPLPQPPAPRAP-----------EGDDFL---S 448
P P A P +QP P PP P +P EG + +
Sbjct: 778 ----------------PPPLAKFPPPSQPQPPPPPPPSPASLLKSLASVLEGQKYCYRGT 821
Query: 449 LHAESDGEGALQVDLGEPAP------APP--AADSRWGGLDLRRKILTQ--------RRE 492
A S G L P P PP AA S G +Q RE
Sbjct: 822 GAAVSTRPGPLPTTQYSPGPPSGATALPPTSAAPSAQGSPQPSASSSSQFSTSGGPWARE 881
Query: 493 RYRQRSPSP---APAPAPAAAAGPPTRKKSR--RERKRSGEAKEAASSSSGTQPAPPA-P 546
R P P P P + PP R +S E R+ E S T PA P
Sbjct: 882 RRAGEEPVPGPMTPTQPPPPLSLPPARSESEVLEEISRACETLVERVGRSATDPADPVDT 941
Query: 547 ASPWDSKKHR------SRDRKPGSHA-SSSARRRSRSRSRSRSTRRRS--RSTDRR-RGG 596
A P DS R +++ G A S S +RR + + RR+ S RR R G
Sbjct: 942 AEPADSGTERLLPPAQAKEEAGGVAAVSGSCKRRQKEHQKEHRRHRRACKDSVGRRPREG 1001
Query: 597 SRRSRSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSG 656
+++++ + + RR S R + D GG+ K K +
Sbjct: 1002 RAKAKAKVPKEKSRRVLGNLDLQSEEIQGREK----SRPDLGGASKAK--------PPTA 1049
Query: 657 DGSEKAPAP-APPPSGSTSCGDRDSRRRGAVPPSI 690
APAP A P S S + +R PP +
Sbjct: 1050 PAPPSAPAPSAQPTPPSASVPGKKAREEAPGPPGV 1084
Score = 73.2 bits (178), Expect = 2e-12
Identities = 172/755 (22%), Positives = 240/755 (31%), Gaps = 190/755 (25%)
Query: 149 PRLRAWRTGKTVSPQSNSSR------PTCARHLTLGTGDGGPAPPPAPSSASSSPSPS-- 200
P L G+ + P ++SSR P HL+L G P PPP P P P+
Sbjct: 428 PALEVSHHGR-LGPSAHSSRKPFLGAPAATPHLSLPPGPSSPPPPPCPRLLRPPPPPAWL 486
Query: 201 --PSS---------------SSPSPPPPPPPPAPP-----APPAPRFDIYDPFHPTDEAY 238
P+ + PP P PPP P PPA RF + T +++
Sbjct: 487 KGPACRAAREDGEILEELFFGTEGPPRPAPPPLPHREGFLGPPASRFSV-----GTQDSH 541
Query: 239 SPPPAPEQKYDPFEP-TGSNPSSSAGT----PSPEEEEEEEEEEEEEEEDEEEEEGLSQS 293
+PP P +GS+ SS AG P P + + ++
Sbjct: 542 TPPTPPTPTTSSSNSNSGSHSSSPAGPVSFPPPPYLARSIDPLPRPPSPAQNPQDPPLVP 601
Query: 294 ISRISETLAGIYDDNSLSQDFPGDESPRPDAQ-PTQPTPAPGTPPQVDSTRADGAMRRRV 352
++ + S F ESPRP P P PG PP
Sbjct: 602 LTLALPPAPPSSCHQNTSGSFRRPESPRPRVSFPKTPEVGPGPPP--------------- 646
Query: 353 FVVGTEAEACREGKVSVEVVTAGGAAL----PPPLLPPGDSEIEEGEIVQPEEEPRLALS 408
G ++A + V + A G L P PL E + +P E L
Sbjct: 647 ---GPLSKAPQPVPPGVGELPARGPRLFDFPPTPL---------EDQFEEPAEFKIL--- 691
Query: 409 LFRPGGRAARPTPAASATPTAQPLPQPPA---PRAPEGDDFLSLHAESDGEGALQVDLGE 465
P G A + + Q A P+ P + F SL + + A
Sbjct: 692 ---PDGLANIMKMLDESIRKEEEQQQHEAGVAPQPPLKEPFASLQSPFPTDTA------- 741
Query: 466 PAPAPPAADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKR 525
P PA TQ E+ P PA P P A PP
Sbjct: 742 PTTTAPAVAVTTTTTTTTTTTATQEEEK----KPPPALPPPPPLAKFPPP---------- 787
Query: 526 SGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRR 585
S QP PP P SP K + + + R + STR
Sbjct: 788 -----------SQPQPPPPPPPSPASLLKSLASVLEGQKYCY-------RGTGAAVSTRP 829
Query: 586 RSRSTDRRRGGSRRSRSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKK 645
T + G + SA P S+SSSS+ GG +++
Sbjct: 830 GPLPTTQYSPGPPSGATALPPTSAAPSAQGSPQPSASSSSQ-------FSTSGGPWARER 882
Query: 646 RSRSRGEKRSGDGSEKAPAPA----PPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAI 701
R+ G E P P PPP S +S + + + L +
Sbjct: 883 RA----------GEEPVPGPMTPTQPPPPLSLPPARSESEVLEEISRACETLVER----- 927
Query: 702 KRTITVGRLDKSDPRGP--SPAPASSPKREVLYDSEGLSGEERGG------------KSS 747
VGR +DP P + PA S +L ++ + EE GG K
Sbjct: 928 -----VGR-SATDPADPVDTAEPADSGTERLLPPAQ--AKEEAGGVAAVSGSCKRRQKEH 979
Query: 748 QKDRRRSGAASSSSSSRE-------------KGSRRKALDGGDRDRDRDRDRDRDR---- 790
QK+ RR A S R K R+ L D + + R++ R
Sbjct: 980 QKEHRRHRRACKDSVGRRPREGRAKAKAKVPKEKSRRVLGNLDLQSEEIQGREKSRPDLG 1039
Query: 791 SSKKARPPKESAPSSGPPPK----PPVSSGSGSSS 821
+ KA+PP AP S P P PP +S G +
Sbjct: 1040 GASKAKPPTAPAPPSAPAPSAQPTPPSASVPGKKA 1074
Score = 55.5 bits (132), Expect = 3e-07
Identities = 106/453 (23%), Positives = 143/453 (31%), Gaps = 111/453 (24%)
Query: 139 PIPLPVPSLLPRLRAWRTGKTVSPQSNSSRPTCARHLTLGTGDGGPAPPPAPSSASSSPS 198
P+ PVP P + +G+ R C T G G P PPP P
Sbjct: 204 PVVQPVP---PAALSGPSGEEGLSPGGKRRRGCNSEQT-GLPPGLPLPPP--------PL 251
Query: 199 PSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDP----------FHPTDEAYSPPPAPEQKY 248
P P P PPPPPPPP P +P F + P + P + +PP EQ++
Sbjct: 252 PPP----PPPPPPPPPPLPGLATSPPFQLTKPGLWSTLHGDAWGPERKGSAPPERQEQRH 307
Query: 249 DPFEP--------TGSNPSS---SAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRI 297
P T P A P P E L +S +
Sbjct: 308 SLPHPYPYPAPAYTAHPPGHRLVPAAPPGPGPRPPGAESHGCLPATRPPGSDLRESRVQR 367
Query: 298 SETLAGIYDDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVVGT 357
S D+S+S P + P++P PGT S+ + R V
Sbjct: 368 SRM------DSSVS---PAATTACVPYAPSRPPGLPGTTTSSSSSSSSNTGLRGVEPNPG 418
Query: 358 EAEACREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAA 417
A ++EV G L P + + P P L+L P G ++
Sbjct: 419 IPGADHYQTPALEVSHHG-------RLGPSAHSSRKPFLGAPAATPHLSL----PPGPSS 467
Query: 418 RPTPAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRW 477
P P P + L PP P +G + A DGE ++ G P PA
Sbjct: 468 PPPP-----PCPRLLRPPPPPAWLKGPACRA--AREDGEILEELFFGTEGPPRPA----- 515
Query: 478 GGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSS 537
P P P GPP + S + S
Sbjct: 516 -----------------------PPPLPHREGFLGPPASRFS------------VGTQDS 540
Query: 538 GTQPAPPAPASPWDSKKHRSRDRKPGSHASSSA 570
T P PP P + S + GSH+SS A
Sbjct: 541 HTPPTPPTPTT-------SSSNSNSGSHSSSPA 566
Score = 43.5 bits (101), Expect = 0.001
Identities = 104/428 (24%), Positives = 142/428 (33%), Gaps = 84/428 (19%)
Query: 139 PIPLPVPSL-------LPRLRAWRT--GKTVSPQSNSSRPTCARHLTLGTGDGGPAPPPA 189
P P P+P L L + W T G P+ S P + P P PA
Sbjct: 260 PPPPPLPGLATSPPFQLTKPGLWSTLHGDAWGPERKGSAPPERQEQRHSLPH--PYPYPA 317
Query: 190 PSSASSSPSPSPSSSSPSPPPPPPPPAP-----PAPPAPRFDIYD---PFHPTDEAYSP- 240
P+ + P ++P P P PP A PA P D+ + D + SP
Sbjct: 318 PAYTAHPPGHRLVPAAPPGPGPRPPGAESHGCLPATRPPGSDLRESRVQRSRMDSSVSPA 377
Query: 241 ------PPAPEQKYD-PFEPTGSNPSSSAGT------PSPEEEEEEEEEEEEEEEDEEEE 287
P AP + P T S+ SSS+ T P+P + + E
Sbjct: 378 ATTACVPYAPSRPPGLPGTTTSSSSSSSSNTGLRGVEPNPGIPGADHYQTPALEVSHHGR 437
Query: 288 EGLSQSISRISETLAGIYDDNSLSQDFPGDESPRPDAQP--TQPTPAPG--TPPQVDSTR 343
G S SR L LS PG SP P P +P P P P + R
Sbjct: 438 LGPSAHSSR-KPFLGAPAATPHLSLP-PGPSSPPPPPCPRLLRPPPPPAWLKGPACRAAR 495
Query: 344 ADGAMRRRVFVVGTEAEACREGKVSVEVVTAGGAALPPPL------LPPGDSEI----EE 393
DG + +F GTE PPPL L P S ++
Sbjct: 496 EDGEILEELF-FGTEGPP---------------RPAPPPLPHREGFLGPPASRFSVGTQD 539
Query: 394 GEIVQPEEEPRLALSLFRPGGRAARPTPAASATP------TAQPLPQPPAPRAPEGDDFL 447
P + S G ++ P S P + PLP+PP+P D L
Sbjct: 540 SHTPPTPPTPTTSSSNSNSGSHSSSPAGPVSFPPPPYLARSIDPLPRPPSPAQNPQDPPL 599
Query: 448 SLHAESDGEGALQVDLGEPAPAPPAADSRWGGLDLRRKILTQRRERY-RQRSPSPAPAPA 506
+ + L P PAPP++ + RR + R + + P P P
Sbjct: 600 -----------VPLTLALP-PAPPSSCHQNTSGSFRRPESPRPRVSFPKTPEVGPGPPPG 647
Query: 507 PAAAAGPP 514
P + A P
Sbjct: 648 PLSKAPQP 655
Score = 43.1 bits (100), Expect = 0.002
Identities = 109/493 (22%), Positives = 146/493 (29%), Gaps = 63/493 (12%)
Query: 184 PAPPPAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEAYSP-PP 242
P PPP S+ P S+ PP P P PP+ + HP+ Y+P P
Sbjct: 33 PHPPPR-----SAWLPGGRCSASIGQPPLPAPLPPSHGS------SSGHPSKPYYAPGAP 81
Query: 243 APEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISETLA 302
P + E + P+ E+ + E E D EE S R + A
Sbjct: 82 TPRPLHGKLESLHGCVQALLREPAQPGLWEQLGQLYESEHDSEEATRCYHSALRYGGSFA 141
Query: 303 ------GIYDDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVVG 356
G L G R P P ++ R GA R G
Sbjct: 142 ELGPRIGRLQQAQLWNFHTGSCQHRAKVLP--PLEQVWNLLHLEHKRNYGAKRG-----G 194
Query: 357 TEAEACREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRA 416
+ E V V PP G S EEG + P + R + + G
Sbjct: 195 PPVKRAAEPPVVQPV---------PPAALSGPSG-EEG--LSPGGKRRRGCNSEQTGLPP 242
Query: 417 ARPTPAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSR 476
P P PLP PP P P L + L +P
Sbjct: 243 GLPLPPP-------PLPPPPPPPPPPPPPLPGLATSPPFQ------LTKPGLWSTLHGDA 289
Query: 477 WGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSS 536
WG R+ R+ R P P P PAPA A PP + G + + S
Sbjct: 290 WG--PERKGSAPPERQEQRHSLPHPYPYPAPAYTAHPPGHRLVPAAPPGPG-PRPPGAES 346
Query: 537 SGTQPAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGG 596
G PA P S D ++ R + + S S +A + SR +T
Sbjct: 347 HGCLPATRPPGS--DLRESRVQRSRMDSSVSPAATTACVPYAPSRPPGLPGTTTS----- 399
Query: 597 SRRSRSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSG 656
S S R P P + + H G R G +
Sbjct: 400 ---SSSSSSSNTGLRGVEPNPGIPGADHYQTPALEVSHHGRLGPSAHSSRKPFLGAPAAT 456
Query: 657 DGSEKAPAPAPPP 669
P P+ PP
Sbjct: 457 PHLSLPPGPSSPP 469
Score = 39.3 bits (90), Expect = 0.025
Identities = 187/944 (19%), Positives = 265/944 (28%), Gaps = 253/944 (26%)
Query: 184 PAPPPAPSSASSSPSPSPSSSS---------------PSPPPPPPPPAPPAPPAPRFDIY 228
P PP A S S SP P PPPP PPP PP PP P
Sbjct: 208 PVPPAALSGPSGEEGLSPGGKRRRGCNSEQTGLPPGLPLPPPPLPPPPPP-PPPP----- 261
Query: 229 DPFHPTDEAYSPPPAPEQKYDP-FEPT--GSNPSSSAGTPSPEEEEEEEEEEEEEEEDEE 285
PPP P P F+ T G + PE + E +E+
Sbjct: 262 -----------PPPLPGLATSPPFQLTKPGLWSTLHGDAWGPERKGSAPPERQEQR---- 306
Query: 286 EEEGLSQSISRISETLAGIYDDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRAD 345
+SL +P +P A P P PP R
Sbjct: 307 ----------------------HSLPHPYPYP-APAYTAHPPGHRLVPAAPPG-PGPRPP 342
Query: 346 GAMRRRVFVVGTEAEACREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEIVQPEEEPRL 405
GA E+ C P PPG S++ E
Sbjct: 343 GA----------ESHGCL-----------------PATRPPG-SDLRES----------- 363
Query: 406 ALSLFRPGGRAARPTPAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGE 465
R R +S +P A P AP P G + + S + E
Sbjct: 364 ---------RVQRSRMDSSVSPAATTACVPYAPSRPPGLPGTTTSSSSSSSSNTGLRGVE 414
Query: 466 PAPAPPAAD---------SRWGGL-----DLRRKILTQRRERYRQRSP----SPAPAPAP 507
P P P AD S G L R+ L P SP P P P
Sbjct: 415 PNPGIPGADHYQTPALEVSHHGRLGPSAHSSRKPFLGAPAATPHLSLPPGPSSPPPPPCP 474
Query: 508 AAAAGPPT----RKKSRRERKRSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPG 563
PP + + R + GE E + P P P P HR P
Sbjct: 475 RLLRPPPPPAWLKGPACRAAREDGEILEELFFGTEGPPRPAPPPLP-----HREGFLGPP 529
Query: 564 SHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPATSSSS 623
+ S + S + +PP T+SSS
Sbjct: 530 ASRFSVGTQDSHT-----------------------------------PPTPPTPTTSSS 554
Query: 624 SSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAP--------PPSGSTSC 675
+S H +RS + P P PP+ +SC
Sbjct: 555 NSNSGSHSSSPAGPVSFPPPPYLARSIDPLPRPPSPAQNPQDPPLVPLTLALPPAPPSSC 614
Query: 676 GDRDS---RRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVLY 732
S RR + P + ++ + + + P G PA P+ L+
Sbjct: 615 HQNTSGSFRRPESPRPRVSFPKTPEVGPGPPPGPLSKAPQPVPPGVGELPARGPR---LF 671
Query: 733 DSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDRSS 792
D E++ + ++ G A+ K LD R + + +
Sbjct: 672 DFPPTPLEDQFEEPAEFKILPDGLANIM----------KMLDESIRKEEEQQQHE----- 716
Query: 793 KKARPPKESAPSSGPPPKPPVSSGSGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPAK 852
+G P+PP+ S S + VAV ++TT A
Sbjct: 717 ------------AGVAPQPPLKEPFASLQSPFPTDTAPTTTAPAVAVTTTTTTTTTTTA- 763
Query: 853 DAASAGLGSIGVKFSRDRESRSPFLKPDERAPTEMAKAAPGSTK------PKKTKVKAKA 906
+++ E + P P P +AK P S P K+
Sbjct: 764 --------------TQEEEKKPPPALPP---PPPLAKFPPPSQPQPPPPPPPSPASLLKS 806
Query: 907 GAKKTKGTKGKTKPSKTRKKVRSGG------GSGGSGGQVSLKKSKADSCSQAAGTKGAE 960
A +G K + + R G G G +L + A +Q + A
Sbjct: 807 LASVLEGQKYCYRGTGAAVSTRPGPLPTTQYSPGPPSGATALPPTSAAPSAQGSPQPSAS 866
Query: 961 ETS--------WSGEERAAKVPSTPPPKAAPPPPALTPDSQTVDSSCKTPEVSFLPEEAT 1012
+S W+ E RA + P P PPP L+ +S E+S E
Sbjct: 867 SSSQFSTSGGPWARERRAGEEPVPGPMTPTQPPPPLSLPPARSESEV-LEEISRACETLV 925
Query: 1013 EEAGVRGGAEEEEEEEEEEEEEEEEEEQQPATTTATSTAAAAPS 1056
E G + + E + E PA + AA S
Sbjct: 926 ERVGRSATDPADPVDTAEPADSGTERLLPPAQAKEEAGGVAAVS 969
Score = 35.8 bits (81), Expect = 0.28
Identities = 52/242 (21%), Positives = 85/242 (35%), Gaps = 23/242 (9%)
Query: 791 SSKKARPPKESAPSSGPPPKPPVSSGSGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTP 850
S A PP +APS+ P+P SS S S+S + + + V + P
Sbjct: 843 SGATALPPTSAAPSAQGSPQPSASSSSQFSTSGGPWARERRAGEEPVPGPMTP-TQPPPP 901
Query: 851 AKDAASAGLGSIGVKFSRDRES---RSPFLKPDERAPTEMAKAA---------PGSTKPK 898
+ + + SR E+ R D P + A+ A P K +
Sbjct: 902 LSLPPARSESEVLEEISRACETLVERVGRSATDPADPVDTAEPADSGTERLLPPAQAKEE 961
Query: 899 KTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLK-KSKADSCSQAAGTK 957
V A +G+ K + + + + + R+ + G G+ K K + + G
Sbjct: 962 AGGVAAVSGSCKRRQKEHQKEHRRHRRACKDSVGRRPREGRAKAKAKVPKEKSRRVLGNL 1021
Query: 958 GAEETSWSGEERAAK----VPSTPPPKAAPPPPALTPDSQTVDSSCKTPEVSFLPEEATE 1013
+ G E++ PP A PP A P +Q S P ++A E
Sbjct: 1022 DLQSEEIQGREKSRPDLGGASKAKPPTAPAPPSAPAPSAQPTPPSASVP-----GKKARE 1076
Query: 1014 EA 1015
EA
Sbjct: 1077 EA 1078
Score = 32.0 bits (71), Expect = 4.0
Identities = 16/39 (41%), Positives = 24/39 (61%), Gaps = 5/39 (12%)
Query: 1021 AEEEEEEEEEEEEEEEEEEQQPATTTATSTAAAAPSTAP 1059
A +E +EE+E E+EE ++P +TT T PS+AP
Sbjct: 1285 ASSFQESLQEEKESEDEESEEPDSTTGT-----PPSSAP 1318
>gi|239758013 PREDICTED: hypothetical protein [Homo sapiens]
Length = 819
Score = 84.3 bits (207), Expect = 7e-16
Identities = 117/528 (22%), Positives = 204/528 (38%), Gaps = 71/528 (13%)
Query: 464 GEPAPAPPAADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTR----KKS 519
G+ A AA ++ GG ++ + + R +QR P A+AAG +R KK
Sbjct: 329 GQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKG 388
Query: 520 RRERKRSGEAKEAASSSSGTQPAPPAPASP---WDSKKHRSRDRKPGSHASSSARRRSRS 576
RE KR G+ ++ + + A APA+ SKK R R G A+ S +SRS
Sbjct: 389 LREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRR----GPKAAKSRGGKSRS 444
Query: 577 RSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPATS---SSSSSRRERHRGK 633
+ RR ++ + SR +K+ R++ SA+ + S S + RG+
Sbjct: 445 GGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQ 504
Query: 634 HRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDL 693
+ G K ++SRG K+ + PA + S G + +R+ AV
Sbjct: 505 KAEAAGEKATAAGAKSRGRKQ-----PRRQKPAVAGAKSRVGGSKSRQRQKAV------- 552
Query: 694 TDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQKDRRR 753
A T G +K G P + + + RGG Q ++
Sbjct: 553 ------AAGATSHGGGGNKQSRGGGGNKPRQ-------WGQTAAAAKTRGGGDKQPGWQK 599
Query: 754 SGAASSSSSSREKGS---RRKALDGGDRDRD---RDRDRDRDRSSKKARPPKESAPSSGP 807
+ A + S S + G R+KA G + R R +D + K S S G
Sbjct: 600 AAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGK 659
Query: 808 PPKPPVSSGSGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFS 867
P+ + +GS SS+++ ++ + + K R S A+ G+
Sbjct: 660 QPRWQKPAAAGSESSAAAAVGQEAEARKKPR---RRRAKSRGDGGQNAAVGI-------- 708
Query: 868 RDRESRSPFLKPDERAPTEMAKAAPGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKV 927
+P+ + ++ ++ G+ K + GAK K++ K
Sbjct: 709 ------NPWQRRGKKPRLGKSRGGGGA------KSRGSGGAKSRGSGGAKSRSGKKAAAS 756
Query: 928 RSGGGSGGSGGQVSLKKSKADSCSQAAGTKGAEETSWSGEERAAKVPS 975
+S GG G + KS++ + A T G ++ + +G ++ +V S
Sbjct: 757 KSHGGGGAKRRRGGGAKSRS---GEKAVTAGGQKAAAAGGKKPPRVKS 801
Score = 79.3 bits (194), Expect = 2e-14
Identities = 130/542 (23%), Positives = 203/542 (37%), Gaps = 74/542 (13%)
Query: 465 EPAPAPPAADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERK 524
+ A A++R GG +K + R P AAA G S++ R
Sbjct: 90 QKAAGAGGAENRGGG---EQKAAAAGTKSLGGRGRKPRRRGQKAAATG------SKKPRW 140
Query: 525 RSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTR 584
R+ ++ A S + G A A+ S+ KP A++ A+ RS + R R +
Sbjct: 141 RAQKSAAAGSKNRGAGAQKAAAAAGVKSQG----GEKPQKAAAAGAKSRSGKKPRRRGAK 196
Query: 585 RRSRSTDRRRGGSRRSRSR---------EKRRRRRRSASPPPATSSSSSSR-------RE 628
SR + ++G R ++SR +K RR P PA + S R ++
Sbjct: 197 --SRGDEDKKGRQREAKSRFGKTRGGRRKKHRR------PKPAAGGAKSRRGGGKKPQKQ 248
Query: 629 RHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSR--RRGAV 686
R RG+ GG K + +SR G+K+ + A G+ + G++ + R G
Sbjct: 249 RRRGQKAATGG-KSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRG 307
Query: 687 PPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLSGEER---- 742
P S+ R G+ + + + A A+ KR G G+++
Sbjct: 308 PKSLGGQN-------PRWGRGGKKPRRRGQKATKAAAAGTKR-------GGGGQQKAAVV 353
Query: 743 GGKSSQKDRRR---------SGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDRSSK 793
G KS +K RRR S A + S +K R+A GD R + R ++ R ++
Sbjct: 354 GVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGD-GRKKPRWQNPRRRAQ 412
Query: 794 KARPPKESAPSSGPP----PKPPVSSGSGSSSSSSSCSSRK-VKLQSKVAVLIREGVSST 848
KA K S P PK S G S S R+ K + K A E
Sbjct: 413 KAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDK 472
Query: 849 TPAKDAAS-AGLGSIGVKFSRDRESRSPFLKPDERAPTEMAKAAPGSTKPKKTKVKAKAG 907
+ AS AG S G A E A AA ++ +K + K
Sbjct: 473 KQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPA 532
Query: 908 AKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKKSKADSCSQAAGTKGAEETSWSGE 967
K G +K + +K V +G S G GG + + Q T A +T G+
Sbjct: 533 VAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGD 592
Query: 968 ER 969
++
Sbjct: 593 KQ 594
Score = 43.9 bits (102), Expect = 0.001
Identities = 44/156 (28%), Positives = 65/156 (41%), Gaps = 18/156 (11%)
Query: 495 RQRSPSPAPAPAPAAAA---GPPTRKKSRRERKRSGEAKEAASSSSGTQPAPPAPASPWD 551
R + P+ A + + AAAA RKK RR R A S G Q A +PW
Sbjct: 662 RWQKPAAAGSESSAAAAVGQEAEARKKPRRRR--------AKSRGDGGQNAAVG-INPWQ 712
Query: 552 --SKKHRSRDRKPG----SHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREK 605
KK R + G S S A+ R ++SRS ++ + S GG++R R
Sbjct: 713 RRGKKPRLGKSRGGGGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGA 772
Query: 606 RRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSK 641
+ R A ++++ ++ R K R G G K
Sbjct: 773 KSRSGEKAVTAGGQKAAAAGGKKPPRVKSRGGRGQK 808
>gi|149158690 HLA-B associated transcript-2 [Homo sapiens]
Length = 2157
Score = 83.2 bits (204), Expect = 2e-15
Identities = 181/877 (20%), Positives = 278/877 (31%), Gaps = 143/877 (16%)
Query: 178 GTGDGGPAPPPAPSSASSSPSPSPSSSSPSPPPPP----------PPPAPPAPPAPRFDI 227
G+ P PP P + P+P + PPPPP PPP PP PR+ +
Sbjct: 670 GSAPPTPVPPSPPQPVTLGAVPAPQA----PPPPPKALYPGALGRPPPMPPMNFDPRWMM 725
Query: 228 YDPFHPTDEAYSPPPAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEE 287
P+ PP F P G +PS P E + E +
Sbjct: 726 IPPYVDPRLLQGRPPLD------FYPPGVHPSGLV----PRERSDSGGSSSEPFDRHAPA 775
Query: 288 EGLSQSISRISETLAGIYDDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGA 347
+ + LA + D + A P +P P +P + + D
Sbjct: 776 MLRERGTPPVDPKLAWVGDVFT--------------ATPAEPRPLT-SPLRQAADEDDKG 820
Query: 348 MRRRVFVVGTEAEACREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEIVQPEEEPRLAL 407
MR V PPP L E G P +
Sbjct: 821 MRSETPPVPP----------------------PPPYLASYPGFPENGA-------PGPPI 851
Query: 408 SLFRPGGRAARPTPAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDG-EGALQVDLGEP 466
S F RP P + + PP + P ++ L G + A V G
Sbjct: 852 SRFPLEEPGPRPLPWPPGSDEVAKIQTPPPKKEPPKEETAQLTGPEAGRKPARGVGSGGQ 911
Query: 467 APAPPAADSR----WGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRE 522
P PP +SR WG R +R P AP AGP +K
Sbjct: 912 GPPPPRRESRTETRWGP-----------RPGSSRRGIPPEEPGAPPRRAGP-IKKPPPPT 959
Query: 523 RKRSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHASSSARRR---SRSRSR 579
+ K +P P P K ++ P + S + R R S R
Sbjct: 960 KVEELPPKPLEQGDETPKPPKPDPLKITKGKLGGPKETPPNGNLSPAPRLRRDYSYERVG 1019
Query: 580 SRSTRRRSRSTDRRRGGS---------RRSRSREKRRRRRRSASPPPATSSSSSSRRERH 630
S R R R RG R +RSRE R R + +
Sbjct: 1020 PTSCRGRGRGEYFARGRGFRGTYGGRGRGARSREFRSYREFRGDDGRGGGTGGPNHPPAP 1079
Query: 631 RGK-----HRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGA 685
RG+ +G ++ KR R RG + + E AP+ + + G
Sbjct: 1080 RGRTASETRSEGSEYEEIPKRRRQRGSETGSETHESDLAPSDKEAPTPKEGTLTQVPLAP 1139
Query: 686 VPPSIQDLTDHDLFAIK--RTITVGRLDKSDPRG-----PSPAPASSPKREVLYDSEGLS 738
PP F + R T + RG P P SP + L + +
Sbjct: 1140 PPPGAPPSPAPARFTARGGRVFTPRGVPSRRGRGGGRPPPQVCPGWSPPAKSLAPKKPPT 1199
Query: 739 GEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRDR----DRDRSSKK 794
G K K++ G S + G ++ G+R R R R D+ ++
Sbjct: 1200 GPLPPSKEPLKEKLIPGPLSPVARGGSNGGSNVGMEDGERPRRRRHGRAQQQDKPPRFRR 1259
Query: 795 ARPPKESA------------PSSGPPPKPPVSSGSGSSSSSSSCSSRKVKLQSKVAVLIR 842
+ +E+A P+S P P+ +++ + + + + +++ L ++ +
Sbjct: 1260 LKQERENAARGSEGKPSLTLPASAPGPEEALTTVTVAPAPRRA-AAKSPDLSNQNSDQAN 1318
Query: 843 EGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDERAPTEMAK---AAPGSTKPKK 899
E + + + D S G D+E+ P L + T A PG + +
Sbjct: 1319 EEWETASESSDFTSERRG--------DKEAPPPVLLTPKAVGTPGGGGGGAVPGISAMSR 1370
Query: 900 TKVKAKAGAKKTKGTKGKTKPSKTRKKVRSG-GGSGGSGGQVSLKKSKADSCSQAAGTKG 958
+ +A +K + +P R+ R G GG GS G S G
Sbjct: 1371 GDLSQRA-KDLSKRSFSSQRPGMERQNRRPGPGGKAGSSGSSS--GGGGGGPGGRTGPGR 1427
Query: 959 AEETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTV 995
++ SW + ++ P PP PPP P S V
Sbjct: 1428 GDKRSWPSPKNRSRPPEERPPGLPLPPP--PPSSSAV 1462
Score = 79.3 bits (194), Expect = 2e-14
Identities = 199/890 (22%), Positives = 288/890 (32%), Gaps = 200/890 (22%)
Query: 180 GDGGPAPPPAPSSA----SSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTD 235
G+ + PP P +A S P P +P PP PPP P P D D P
Sbjct: 378 GNSPNSEPPTPKTAWAETSRPPETEPGPPAPKPPLPPPHRGPAGNWGPPGDYPDRGGPP- 436
Query: 236 EAYSPPPAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSIS 295
PPAPE + + + SS E EEEE EE ++ +
Sbjct: 437 ---CKPPAPEDEDEAWRQRRKQSSSEISL--AVERARRRREEEERRMQEERRAACAEKLK 491
Query: 296 RISETLAGIYDDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVV 355
R+ E D L E P A P+ P P P P ++ + A
Sbjct: 492 RLDEKFGA--PDKRLKA-----EPAAPPAAPSTPAPPPAVPKELPAPPAPPPASAP--TP 542
Query: 356 GTEAEACREGKVSVEVVTAGGAALPPPLLPPGD-SEIEEGEIVQPEEEPRLALSLFRPGG 414
TE E + + T G AA P + G S G EP+L
Sbjct: 543 ETEPEEPAQAPPAQSTPTPGVAAAPTLVSGGGSTSSTSSGSFEASPVEPQL--------- 593
Query: 415 RAARPTPAASATPTAQPLP-QPPAPRAPEGDDFLSLHAESDGEGALQVDLGEP---APAP 470
P+ P P P PP P+ D + + +G LG P P
Sbjct: 594 ----PSKEGPEPPEEVPPPTTPPVPKVEPKGDGIGPTRQPPSQG-----LGYPKYQKSLP 644
Query: 471 PAADSRWGGLDLRRKILTQRRERYRQRSPSPA-PAPAPAAAAGPPTRKKSRRERKRSGEA 529
P R+ + + Q++ +++Q A P P P + P T +
Sbjct: 645 P----RFQRQQQEQLLKQQQQHQWQQHQQGSAPPTPVPPSPPQPVTLGAVPAPQAPPPPP 700
Query: 530 KEAASSSSG-TQPAPPAPASP-W-------DSKKHRSRD----RKPGSHASSSARRRSRS 576
K + G P PP P W D + + R PG H S
Sbjct: 701 KALYPGALGRPPPMPPMNFDPRWMMIPPYVDPRLLQGRPPLDFYPPGVHPSGLV-----P 755
Query: 577 RSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRR---------RRSASPPPATSSSSSSRR 627
R RS S S DR R R + A P P TS +
Sbjct: 756 RERSDSGGSSSEPFDRHAPAMLRERGTPPVDPKLAWVGDVFTATPAEPRPLTSPLRQAAD 815
Query: 628 ERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVP 687
E +G SE P P PPP ++ G ++ GA
Sbjct: 816 EDDKGMR------------------------SETPPVPPPPPYLASYPGFPEN---GAPG 848
Query: 688 PSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASS----------PKRE-VLYDSEG 736
P I L++ PR P P P S PK+E ++
Sbjct: 849 PPISRFP---------------LEEPGPR-PLPWPPGSDEVAKIQTPPPKKEPPKEETAQ 892
Query: 737 LSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDRSSKKAR 796
L+G E G +K R G+ + SR + G R SS++
Sbjct: 893 LTGPEAG----RKPARGVGSGGQGPPPPRRESRTETRWG-----------PRPGSSRRGI 937
Query: 797 PPKE-SAP--SSGPPPKPPVSSGSGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPAK- 852
PP+E AP +GP KPP + K++ + +G + P K
Sbjct: 938 PPEEPGAPPRRAGPIKKPPPPT----------------KVEELPPKPLEQGDETPKPPKP 981
Query: 853 DAASAGLGSI-GVKFSRDRESRSPFLKPDERAPTEMAKAAPGSTKPK-KTKVKAKA-GAK 909
D G + G K + + SP P R + P S + + + + A+ G +
Sbjct: 982 DPLKITKGKLGGPKETPPNGNLSP--APRLRRDYSYERVGPTSCRGRGRGEYFARGRGFR 1039
Query: 910 KTKGTKGKTKPSKTRKKVRS-------GGGSGG----------SGGQVSLKKSKADSCSQ 952
T G +G+ S+ + R GGG+GG + + + S+ + +
Sbjct: 1040 GTYGGRGRGARSREFRSYREFRGDDGRGGGTGGPNHPPAPRGRTASETRSEGSEYEEIPK 1099
Query: 953 AAGTKGAEETSWSGEERAA---------------KVPSTPPPKAAPPPPA 987
+G+E S + E A +VP PPP APP PA
Sbjct: 1100 RRRQRGSETGSETHESDLAPSDKEAPTPKEGTLTQVPLAPPPPGAPPSPA 1149
Score = 75.1 bits (183), Expect = 4e-13
Identities = 200/901 (22%), Positives = 290/901 (32%), Gaps = 145/901 (16%)
Query: 27 PTLSPSAFILRAIQQAVGSSLQGDLPNDKDGSRCHGLRWRRCRSPRSEPRSQESGGTDTA 86
P + PS + R + GSS + P D+ R +P +P+ G TA
Sbjct: 746 PGVHPSGLVPRERSDSGGSSSE---PFDRHAPAM----LRERGTPPVDPKLAWVGDVFTA 798
Query: 87 TV---------LDMATDSFLAGLVSVLDPPDTWVPSRLDLRPGESEDMLE--LVAEVRIG 135
T L A D G+ S PP P L PG E+ ++ +
Sbjct: 799 TPAEPRPLTSPLRQAADEDDKGMRSET-PPVPPPPPYLASYPGFPENGAPGPPISRFPLE 857
Query: 136 DRDPIPLPVPSLLPRLRAWRTG--KTVSPQSNSSR---PTCARHLTLGTGDG--GPAPPP 188
+ P PLP P + +T K P+ +++ P R G G G GP PP
Sbjct: 858 EPGPRPLPWPPGSDEVAKIQTPPPKKEPPKEETAQLTGPEAGRKPARGVGSGGQGPPPPR 917
Query: 189 APSSASSSPSPSPSSSSPSPPP-----PPPPPAPPAPPAPRFDIYD----PFHPTDEAYS 239
S + P P SS PP PP P P P + + P DE
Sbjct: 918 RESRTETRWGPRPGSSRRGIPPEEPGAPPRRAGPIKKPPPPTKVEELPPKPLEQGDETPK 977
Query: 240 PPPAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISE 299
PP K + G + G SP + E G + +R
Sbjct: 978 PPKPDPLKITKGKLGGPKETPPNGNLSPAPRLRRDYSYERVGPTSCRGRGRGEYFAR-GR 1036
Query: 300 TLAGIYDD---NSLSQDFPGDESPRPDAQPTQPTPAPGTPP-----QVDSTRADGA---- 347
G Y + S++F R D T P PP TR++G+
Sbjct: 1037 GFRGTYGGRGRGARSREFRSYREFRGDDGRGGGTGGPNHPPAPRGRTASETRSEGSEYEE 1096
Query: 348 ----MRRRVFVVGTE------AEACREGKVSVE-VVTAGGAALPPPLLPPGDS----EIE 392
R+R G+E A + +E E +T A PPP PP +
Sbjct: 1097 IPKRRRQRGSETGSETHESDLAPSDKEAPTPKEGTLTQVPLAPPPPGAPPSPAPARFTAR 1156
Query: 393 EGEIVQPEEEPRLALSLFRPGGR----------------AARPTPAASATPTAQPL---- 432
G + P P R GGR A + P P+ +PL
Sbjct: 1157 GGRVFTPRGVPS---RRGRGGGRPPPQVCPGWSPPAKSLAPKKPPTGPLPPSKEPLKEKL 1213
Query: 433 -PQPPAPRAPEGDDFLSLHAESDGEGALQVDLG--EPAPAPPAADSRWGGLDLRRKILTQ 489
P P +P A G + S DGE + G + PP R + L Q
Sbjct: 1214 IPGPLSPVARGGSNGGSNVGMEDGERPRRRRHGRAQQQDKPP-----------RFRRLKQ 1262
Query: 490 RRERYRQRSPSPAPAPAPAAAAGP-------PTRKKSRRERKRSGEAKEAASSSSGTQPA 542
RE + S PA+A GP RR +S + S + +
Sbjct: 1263 ERENAARGSEGKPSLTLPASAPGPEEALTTVTVAPAPRRAAAKSPDLSNQNSDQANEEWE 1322
Query: 543 PPAPASPWDSKKHRSRDRKP----GSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSR 598
+ +S + S++ ++ P A + S R + R + S+
Sbjct: 1323 TASESSDFTSERRGDKEAPPPVLLTPKAVGTPGGGGGGAVPGISAMSRGDLSQRAKDLSK 1382
Query: 599 RSRSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDG 658
RS S ++ R++ P P + SS G GGG + RG+KRS
Sbjct: 1383 RSFSSQRPGMERQNRRPGPGGKAGSS-------GSSSGGGGGGPGGRTGPGRGDKRSWPS 1435
Query: 659 --------SEKAPA-PAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITV-G 708
E+ P P PPP S+S R + + P IQ L + + ++T G
Sbjct: 1436 PKNRSRPPEERPPGLPLPPPPPSSSAVFRLDQVIHSNPAGIQQAL-AQLSSRQGSVTAPG 1494
Query: 709 RLDKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGS 768
+ P P SP+ Y+ + R + SS E G
Sbjct: 1495 GHPRHKPGLPQAPQGPSPRPPTRYEPQ----------------RVNSGLSSDPHFEEPGP 1538
Query: 769 RRKALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSSSSSCSS 828
+ + G RD R + R P+ S PPP GS S
Sbjct: 1539 MVRGVGGTPRDSAGVSPFPPKRRERPPRKPELLQEESLPPPHSSGFLGSKPEGPGPQAES 1598
Query: 829 R 829
R
Sbjct: 1599 R 1599
Score = 70.9 bits (172), Expect = 8e-12
Identities = 225/1148 (19%), Positives = 344/1148 (29%), Gaps = 193/1148 (16%)
Query: 168 RPTCARHLT-LGTGDGGP-----APPPAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAPP 221
R CA L L G P A P AP +A S+P+P P+ P PP PPPA + P
Sbjct: 483 RAACAEKLKRLDEKFGAPDKRLKAEPAAPPAAPSTPAPPPAVPKELPAPPAPPPA--SAP 540
Query: 222 APRFDIYDPFHPTDEAYSPPPAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEE 281
P + +P +P P GS S+S+G+ E + +E E
Sbjct: 541 TPETEPEEPAQAPPAQSTPTPGVAAAPTLVSGGGSTSSTSSGSFEASPVEPQLPSKEGPE 600
Query: 282 EDEEEEEGLSQSISRISETLAGIYDDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDS 341
EE + + ++ GI G P P PP+
Sbjct: 601 PPEEVPPPTTPPVPKVEPKGDGI-----------GPTRQPPSQGLGYPKYQKSLPPRFQR 649
Query: 342 TRADGAMRRRVFVVGTEAEACREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEIVQPEE 401
+ + ++++ + + G+A P P+ P + G + P+
Sbjct: 650 QQQEQLLKQQQQHQWQQHQQ--------------GSAPPTPVPPSPPQPVTLGAVPAPQA 695
Query: 402 EPRLALSLFRPGGRAARPTPAASATPTAQPLPQPPAPRAPEGDDFLSLH----------- 450
P +L+ P P + P +P PR +G L +
Sbjct: 696 PPPPPKALYPGALGRPPPMPPMNFDPRWMMIPPYVDPRLLQGRPPLDFYPPGVHPSGLVP 755
Query: 451 -AESDGEGALQVDLGEPAPA------PPAADSR--WGGLDLRRKILTQRRERYRQRSPSP 501
SD G+ APA P D + W G + + P
Sbjct: 756 RERSDSGGSSSEPFDRHAPAMLRERGTPPVDPKLAWVG------------DVFTATPAEP 803
Query: 502 APAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSG----TQPAPPAPASPWDSKKHRS 557
P +P A K R E +S G P PP P + R
Sbjct: 804 RPLTSPLRQAADEDDKGMRSETPPVPPPPPYLASYPGFPENGAPGPPISRFPLEEPGPRP 863
Query: 558 RDRKPGS------HASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRR 611
PGS + + + + R R G + +R R
Sbjct: 864 LPWPPGSDEVAKIQTPPPKKEPPKEETAQLTGPEAGRKPARGVGSGGQGPPPPRRESRTE 923
Query: 612 SASPPPATSSSSSSRRERHRGKHRDGGGSKK----KKKRSRSRGEKRSGDGSEKAPAPAP 667
+ P SS E R G KK K GD + K P P P
Sbjct: 924 TRWGPRPGSSRRGIPPEEPGAPPRRAGPIKKPPPPTKVEELPPKPLEQGDETPKPPKPDP 983
Query: 668 --------------PPSGSTSCGD---RDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRL 710
PP+G+ S RD P S + + FA R G
Sbjct: 984 LKITKGKLGGPKETPPNGNLSPAPRLRRDYSYERVGPTSCRGRGRGEYFARGR----GFR 1039
Query: 711 DKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRR 770
RG +G G G R R+ + + S S + +
Sbjct: 1040 GTYGGRGRGARSREFRSYREFRGDDGRGGGTGGPNHPPAPRGRTASETRSEGSEYEEIPK 1099
Query: 771 KALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSSSSSCSSRK 830
+ G + D S K+A PKE + P PP G+ S + + ++R
Sbjct: 1100 RRRQRGSETGSETHESDLAPSDKEAPTPKEGTLTQVPLAPPP--PGAPPSPAPARFTARG 1157
Query: 831 VKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDERAPTEMAKA 890
++ + V R G P G + + P P + P + K
Sbjct: 1158 GRVFTPRGVPSRRGRGGGRPPPQVC-PGWSPPAKSLAPKKPPTGPL--PPSKEPLK-EKL 1213
Query: 891 APGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKKSKADSC 950
PG P A+ G + G R + R G + ++ K +
Sbjct: 1214 IPGPLSP-----VARGG---SNGGSNVGMEDGERPRRRRHGRAQQQDKPPRFRRLKQERE 1265
Query: 951 SQAAGTKGAEETSWSG-----EERAAKVPSTPPPK--AAPPPPALTPDSQTVDSSCKT-- 1001
+ A G++G + EE V P P+ AA P +S + +T
Sbjct: 1266 NAARGSEGKPSLTLPASAPGPEEALTTVTVAPAPRRAAAKSPDLSNQNSDQANEEWETAS 1325
Query: 1002 ----------------PEVSFLPEEATEEAGVRGGAEEEEEEEEEEEEEEEEEEQQPATT 1045
P V P+ G GGA + + ++ +
Sbjct: 1326 ESSDFTSERRGDKEAPPPVLLTPKAVGTPGGGGGGAVPGISAMSRGDLSQRAKDLSKRSF 1385
Query: 1046 TATSTAAAAPSTAPSAGSTAGDSGAEDG-----------------------------PAS 1076
++ + P G AG SG+ G P
Sbjct: 1386 SSQRPGMERQNRRPGPGGKAGSSGSSSGGGGGGPGGRTGPGRGDKRSWPSPKNRSRPPEE 1445
Query: 1077 RVSQLPTLPPPMPWNLPAGVDCTTSGVLALTALLFKME---EANLASRAKAQELIQATNQ 1133
R LP LPPP P ++S V L ++ + LA + Q + A
Sbjct: 1446 RPPGLP-LPPPPP---------SSSAVFRLDQVIHSNPAGIQQALAQLSSRQGSVTAPGG 1495
Query: 1134 ILSHRK--PPSSLGMTPAPVPT-------SLGLPPGPSSYLLPGSLPLGGCGSTPPTPTG 1184
H+ P + G +P P PT + GL P + PG + + G G TP G
Sbjct: 1496 HPRHKPGLPQAPQGPSPRP-PTRYEPQRVNSGLSSDP-HFEEPGPM-VRGVGGTPRDSAG 1552
Query: 1185 LAATSDKR 1192
++ KR
Sbjct: 1553 VSPFPPKR 1560
Score = 57.0 bits (136), Expect = 1e-07
Identities = 186/945 (19%), Positives = 309/945 (32%), Gaps = 171/945 (18%)
Query: 436 PAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGGLDLRRKI-----LTQR 490
P + +G + SL+ +G +++ +PA AP G + + R++ L
Sbjct: 7 PTAKGKDGKKYSSLNLFDTYKGK-SLEIQKPAVAPRHGLQSLGKVAIARRMPPPANLPSL 65
Query: 491 RERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQPAPPAPASPW 550
+ + P+ + P G K + +S +A A S PA PAS
Sbjct: 66 KAENKGNDPNVSLVPKD----GTGWASKQEQSDPKSSDASTAQPPESQPLPASQTPASNQ 121
Query: 551 DSKKHRSRDRKP------GSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSRE 604
+ + + P S A +S + R++ SR + + + ++
Sbjct: 122 PKRPPAAPENTPLVPSGVKSWAQASVTHGAHGDG-GRASSLLSRFSREEFPTLQAAGDQD 180
Query: 605 KRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRS----RGEKRSGDGSE 660
K + R SA +S S R ++ RDGGG + G G
Sbjct: 181 KAAKERESAEQ---SSGPGPSLRPQNSTTWRDGGGRGPDELEGPDSKLHHGHDPRGGLQP 237
Query: 661 KAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQD--LTDHDLFAIKRTITVGRLDKSDPRGP 718
P PP RG +PP + L + + G P GP
Sbjct: 238 SGPPQFPP-------------YRGMMPPFMYPPYLPFPPPYGPQ-----GPYRYPTPDGP 279
Query: 719 SPAPASSPKREVLYDSEGLSGEERGGKSS--QKDRRRSGAASSSSSSREKGSRRKALDGG 776
S P + R + E G+ S ++D + + + +D
Sbjct: 280 SRFPRVAGPRG---SGPPMRLVEPVGRPSILKEDNLKEFDQLDQENDDGWAGAHEEVDYT 336
Query: 777 DRDRDRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSSSSSCSSRKVKLQSK 836
++ + D + RD + A ++S +SG P G+S +S + + ++
Sbjct: 337 EKLKFSDEEDGRDSDEEGAEGHRDSQSASGEERPPEADGKKGNSPNSEPPTPKTAWAETS 396
Query: 837 VAVLIREGVSSTTPAKDAASAG-LGSIGVKFSRDRESRSPFLKPDERAPTEMAKAAPGST 895
G + P G G+ G P PD P
Sbjct: 397 RPPETEPGPPAPKPPLPPPHRGPAGNWG----------PPGDYPDRGGPP---------C 437
Query: 896 KPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKKSKADSCSQAAG 955
KP + + +A ++ K + + + R + R + +++ + +C++
Sbjct: 438 KPPAPEDEDEAWRQRRKQSSSEISLAVERARRRR------EEEERRMQEERRAACAEKL- 490
Query: 956 TKGAEETSWSGEERAAKVPSTPP--PKAAPPPPALTPDSQTVDSSCKTPEVSFLPEEATE 1013
K +E + ++R P+ PP P PPPA+ + LP
Sbjct: 491 -KRLDEKFGAPDKRLKAEPAAPPAAPSTPAPPPAVPKE---------------LPAPP-- 532
Query: 1014 EAGVRGGAEEEEEEEEEEEEEEEEEEQQPATTTATSTAAAAPSTAPSAGSTAGDSG---- 1069
A E E EE + PA +T T AAAP+ GST+ S
Sbjct: 533 -------APPPASAPTPETEPEEPAQAPPAQSTPTPGVAAAPTLVSGGGSTSSTSSGSFE 585
Query: 1070 ---------AEDGPASRVSQLPTLPPPMPWNLPAGVDCTTSGVLALTALLFKMEEANLAS 1120
+++GP P PP+P P G + L + + +L
Sbjct: 586 ASPVEPQLPSKEGPEPPEEVPPPTTPPVPKVEPKGDGIGPTRQPPSQGLGYPKYQKSLPP 645
Query: 1121 RAKAQELIQATNQILSHR--------KPPSSLGMTPAPVPTSLG------LPPGPSSYLL 1166
R + Q+ Q Q H+ PP+ + +P P P +LG PP P L
Sbjct: 646 RFQRQQQEQLLKQQQQHQWQQHQQGSAPPTPVPPSP-PQPVTLGAVPAPQAPPPPPKALY 704
Query: 1167 PGSLPLGGCGSTPPTPTGLAATSDKR-------EGSSSSEGRGDTDKYLKKLHTQERAVE 1219
PG+L G PP P D R +GR D Y +H
Sbjct: 705 PGAL-----GRPPPMP---PMNFDPRWMMIPPYVDPRLLQGRPPLDFYPPGVHPSGLVPR 756
Query: 1220 EVKLAIKPYYQKKDITKEEYKDILRKAVHKICHSKSGEINP--VKVSNLVRAYVQRYRYF 1277
E + D + R A + + ++P V ++ A R
Sbjct: 757 E----------RSDSGGSSSEPFDRHAPAMLRERGTPPVDPKLAWVGDVFTATPAEPRPL 806
Query: 1278 RKHGRKPGD----------PPGPPRPP---KEPGPPDKGGPGLPL 1309
R+ D PP PP PP PG P+ G PG P+
Sbjct: 807 TSPLRQAADEDDKGMRSETPPVPPPPPYLASYPGFPENGAPGPPI 851
Score = 49.3 bits (116), Expect = 2e-05
Identities = 84/391 (21%), Positives = 128/391 (32%), Gaps = 62/391 (15%)
Query: 180 GDGGPAPPPAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEAYS 239
G GP P S PS PP PP PP +Y P+ P Y
Sbjct: 211 GGRGPDELEGPDSKLHHGHDPRGGLQPSGPPQFPPYRGMMPPF----MYPPYLPFPPPYG 266
Query: 240 P--------PPAPEQKYDPFEPTGSNPS----SSAGTPSPEEEEEEEEEEEEEEEDEEEE 287
P P P + P GS P G PS +E+ +E ++ ++E+++
Sbjct: 267 PQGPYRYPTPDGPSRFPRVAGPRGSGPPMRLVEPVGRPSILKEDNLKEFDQLDQENDDGW 326
Query: 288 EGLSQSISRISETLAGIYDDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGA 347
G + + +E L +++ D G E R +Q PP+ D + +
Sbjct: 327 AGAHEEVD-YTEKLKFSDEEDGRDSDEEGAEGHR----DSQSASGEERPPEADGKKGNSP 381
Query: 348 MRRRVFVVGTEAEACREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEIVQPEEEPRLAL 407
AE R + T G P P LPP P P
Sbjct: 382 NSEPPTPKTAWAETSRPPE------TEPGPPAPKPPLPP------------PHRGP---- 419
Query: 408 SLFRPGGRAARPTPAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPA 467
A P P +PPAP E + + +S E +L V+
Sbjct: 420 --------AGNWGPPGDYPDRGGPPCKPPAPE-DEDEAWRQRRKQSSSEISLAVERARRR 470
Query: 468 PAPPAADSRWGGLDLRRKILTQRRERYRQRSPSP------APAPAPAAAAGPPTRKKSRR 521
+ + RR ++ +R ++ +P PA PAA + P +
Sbjct: 471 REEEERRMQ----EERRAACAEKLKRLDEKFGAPDKRLKAEPAAPPAAPSTPAPPPAVPK 526
Query: 522 ERKRSGEAKEAASSSSGTQPAPPAPASPWDS 552
E A++ + T+P PA A P S
Sbjct: 527 ELPAPPAPPPASAPTPETEPEEPAQAPPAQS 557
Score = 45.1 bits (105), Expect = 5e-04
Identities = 140/692 (20%), Positives = 210/692 (30%), Gaps = 123/692 (17%)
Query: 126 LELVAEVRIGDRDPIPLPVPSLLPRLRAWRTGKTVSPQSNSSRPTCARHLTLGTGDGGPA 185
L+ + +V I R P P +PSL + ++ P+ + + + D A
Sbjct: 44 LQSLGKVAIARRMPPPANLPSLKAENKGNDPNVSLVPKDGTGWASKQEQSDPKSSDASTA 103
Query: 186 PPPAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEAYSPPPAPE 245
PP S S +P+S+ P PP P P P + + T A+
Sbjct: 104 QPP--ESQPLPASQTPASNQPKRPPAAPENTPLVPSGVK--SWAQASVTHGAHGDGGRAS 159
Query: 246 QKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISETLAGIY 305
F +AG ++++ +E E E+ G S+ + T
Sbjct: 160 SLLSRFSREEFPTLQAAG---------DQDKAAKERESAEQSSGPGPSLRPQNSTT--WR 208
Query: 306 DDNSLSQD-FPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAEACRE 364
D D G +S + P PPQ R G M ++
Sbjct: 209 DGGGRGPDELEGPDSKLHHGHDPRGGLQPSGPPQFPPYR--GMMPPFMY----------- 255
Query: 365 GKVSVEVVTAGGAALPPPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPTPAAS 424
PPP P G + P PR+A G R + P
Sbjct: 256 ---------PPYLPFPPPYGPQGPYRYPTPD--GPSRFPRVA------GPRGSGP----- 293
Query: 425 ATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGA---LQVDLGEPAPAPPAADSRWGGLD 481
+P+ +P + +F L E+D A +VD E D R +
Sbjct: 294 PMRLVEPVGRPSILKEDNLKEFDQLDQENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEE 353
Query: 482 LRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQP 541
+ +R P + + PPT K + E R E T+P
Sbjct: 354 GAEGHRDSQSASGEERPPEADGKKGNSPNSEPPTPKTAWAETSRPPE----------TEP 403
Query: 542 APPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSR 601
PPAP P HR G R + + + R++ S S
Sbjct: 404 GPPAPKPPL-PPPHRGPAGNWGPPGDYPDRGGPPCKPPAPEDEDEAWRQRRKQSSSEISL 462
Query: 602 SREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEK 661
+ E+ RRRR ER + R ++K K+ G + D K
Sbjct: 463 AVERARRRR--------------EEEERRMQEERRAACAEKLKRLDEKFG---APDKRLK 505
Query: 662 APAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPA 721
A APP + ST A PP++ K P P+P
Sbjct: 506 AEPAAPPAAPSTP----------APPPAV--------------------PKELPAPPAPP 535
Query: 722 PASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDRD 781
PAS+P E EE + G A++ + GS G
Sbjct: 536 PASAPTPET-------EPEEPAQAPPAQSTPTPGVAAAPTLVSGGGSTSSTSSGS----F 584
Query: 782 RDRDRDRDRSSKKARPPKESAPSSGPPPKPPV 813
+ SK+ P E P PP P V
Sbjct: 585 EASPVEPQLPSKEGPEPPEEVPPPTTPPVPKV 616
Score = 44.7 bits (104), Expect = 6e-04
Identities = 125/549 (22%), Positives = 186/549 (33%), Gaps = 95/549 (17%)
Query: 156 TGKTVSPQSNSSRPTCARHLTLGTGDGGPA--PPPAPSSASSSPSPSPSSSSPSPPPPPP 213
+G +S S S C++ + G G A PP P +S P ++ P PP
Sbjct: 1651 SGVDLSGDSQVSSGPCSQRSSPDGGLKGAAEGPPKRPGGSS------PLNAVPCEGPPGS 1704
Query: 214 PPAPPAPPAPRFDIYDPFHPTDEAYSP-----PPAP-----EQKYD-PFEPTGSNPSSSA 262
P PPAP H D P PP P Q+ D EP PS
Sbjct: 1705 EPPRRPPPAP--------HDGDRKELPREQPLPPGPIGTERSQRTDRGTEPGPIRPSHRP 1756
Query: 263 GTPSPEEEEEEEEEEEEEEEDE-EEEEGLSQSIS---------RISETLAGIYDDNSLSQ 312
G P +++ + D + E+ L+ S++ + + A + S +
Sbjct: 1757 GPPVQFGTSDKDSDLRLVVGDSLKAEKELTASVTEAIPVSRDWELLPSAAASAEPQSKNL 1816
Query: 313 DFPGDESPRPDA--QPTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAEACREGKVSVE 370
D G P P + Q P G+ S + GAM ++ + R G S+
Sbjct: 1817 D-SGHCVPEPSSSGQRLYPEVFYGSAGPSSSQISGGAMDSQLH---PNSGGFRPGTPSLH 1872
Query: 371 VVTAGGAALPPPLLPPG--------DSEIEEGEIVQPEEEPRLALSLFRPGGRAARPTPA 422
+ LPP PP + + +Q E +L P G P P+
Sbjct: 1873 PYRSQPLYLPPGPAPPSALLSGLALKGQFLDFSTMQATELGKL------PAGGVLYPPPS 1926
Query: 423 ASATPTAQPLPQPPA------PRAPEGDDFLSLHAESDGEGALQVDLGEPAPAP----PA 472
+P P P P P DF S + G+ L APA P
Sbjct: 1927 FLYSPAFCPSPLPDTSLLQVRQDLPSPSDFYSTPLQPGGQSGF---LPSGAPAQQMLLPM 1983
Query: 473 ADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAA--AAGPPTRKKSRRERKRSGEAK 530
DS+ ++ + P+P PAP P + GP + S R A
Sbjct: 1984 VDSQLPVVN------------FGSLPPAPPPAPPPLSLLPVGPALQPPSLAVRPPPAPAT 2031
Query: 531 EAASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRST 590
S PA P PAS ++ H + + S+ SR+ T R
Sbjct: 2032 RVLPS-----PARPFPASLGRAELHPVELKPFQDYQKLSSNLGGPGSSRTPPTGRSFSGL 2086
Query: 591 DRRRGGSRRSRS---REKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRS 647
+ R + + S R +R + ASPP A ER R+ G ++ +
Sbjct: 2087 NSRLKATPSTYSGVFRTQRVDLYQQASPPDALRWIPKP-WERTGPPPRE--GPSRRAEEP 2143
Query: 648 RSRGEKRSG 656
SRG+K G
Sbjct: 2144 GSRGDKEPG 2152
Score = 31.2 bits (69), Expect = 6.8
Identities = 13/27 (48%), Positives = 15/27 (55%)
Query: 1285 GDPPGPPRPPKEPGPPDKGGPGLPLPP 1311
GD P P PP++ PGLPLPP
Sbjct: 1428 GDKRSWPSPKNRSRPPEERPPGLPLPP 1454
>gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]
Length = 715
Score = 82.8 bits (203), Expect = 2e-15
Identities = 165/750 (22%), Positives = 270/750 (36%), Gaps = 113/750 (15%)
Query: 399 PEEEPRLALSLFRPGGR--AARPTPAAS------ATPTAQPLPQPPAPRAPEGDDFLSLH 450
P+ + ++SL G A P P AS ATP +P PA S+
Sbjct: 4 PKRSSKPSMSLAPSGSSMPTADPKPPASLKSTKSATPNRSLVPTKPATSRN------SVM 57
Query: 451 AESDGEGALQVDLGEPAPAPPAADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAA 510
+ S + P++ SR +R K T R R+ + A
Sbjct: 58 SPSSSKSTKSTSTKRAPSNRPSSRSR-----VRSKARTPSRVSTDTRTSKASKASDVRCH 112
Query: 511 AGPPTRKKSR---RERKRSGEAKEAASSSSG---TQPAPPAPASPWDSKKHRSRDRKPGS 564
T + R R RS + + +S+ G T A P AS + ++ GS
Sbjct: 113 QRRGTHSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMAS----RVRTPTSQQKGS 168
Query: 565 HASSSARRRSRSRSRSRSTRRR-SRSTDRRRGGSRRSRSREKR--------------RRR 609
S R R+ +R RS S R S+ + R GGS RS E +
Sbjct: 169 RGKSYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSK 228
Query: 610 RRSASPPPATS----------------SSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEK 653
+S +P P++S S S + + + + S+SR +
Sbjct: 229 EKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPR 288
Query: 654 RSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLD-- 711
RS GS+K S S SR R I L+ + R+ + G+
Sbjct: 289 RSRSGSQKRTHSRVR---SHSWKRNHSRARSRTRKGI--LSQMGRHSQSRSHSKGKSQNQ 343
Query: 712 -KSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRR 770
++ RG S + +P +E + S +ER + S R+ SG + S S ++++ R
Sbjct: 344 SRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSR 403
Query: 771 KALDGGDRDRDRDR------DRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSSSS 824
RDR R R DR R RS KAR S + S + + S
Sbjct: 404 SRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSR 463
Query: 825 SCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDERAP 884
S S K + +S+ S +P+K+ + LGS S++R+ R R+P
Sbjct: 464 SRSPNKARDRSR----------SRSPSKERDHSQLGSP----SKERDHRR------SRSP 503
Query: 885 TEMAKAAPGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKK 944
++ + + K+ + K + + P+K R + +S S + S
Sbjct: 504 SKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSP 563
Query: 945 SKA-DSCSQAAGTKGAE--ETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTVDSSCKT 1001
SK D + +K E ++ S EER +P ++ P + S K
Sbjct: 564 SKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRAS-------SKEKA 616
Query: 1002 PEVSFLPEEATEEAGVRGGAEEEEEEEEEEEEEEEEEEQQPATT------TATSTAAAAP 1055
S P + + R ++E + + + + T+ T + T++ +P
Sbjct: 617 HSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSP 676
Query: 1056 STAPSAGSTAGDSGAEDGPASRVSQLPTLP 1085
ST PS G T +D A + TLP
Sbjct: 677 STFPSGGQTLSQ---DDSQADATTSKATLP 703
Score = 61.2 bits (147), Expect = 6e-09
Identities = 90/416 (21%), Positives = 142/416 (34%), Gaps = 92/416 (22%)
Query: 450 HAESDGEGALQVDLGEPAPAPPAADSRWGGLDLRRKILTQR-----RERYRQRSP----- 499
H+ S + G +P + S+ G + +R R R+R R RSP
Sbjct: 365 HSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARD 424
Query: 500 -SPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSR 558
S + +P A R+R RS +A S P + + RSR
Sbjct: 425 RSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSP---------NKARDRSR 475
Query: 559 DRKP---------GSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRR 609
R P GS + RRSRS S+ R R+ S+ R RS S+E++RR+
Sbjct: 476 SRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQ 535
Query: 610 RRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPP 669
RS + S S S ER +HR K++ R R R + + +
Sbjct: 536 SRSPNKERDRSQSRSPSEER---EHRQSRSPSKERDRRRWRSPSKERERRQ--------- 583
Query: 670 SGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKRE 729
+S +RD R + SP ++
Sbjct: 584 -SRSSSEERDHSR----------------------------------------SRSPNKQ 602
Query: 730 VLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRD 789
Y S +E+ S+ + + S +SS+E + + R D R R
Sbjct: 603 SGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTV---PRSPDWKRSPTRT 659
Query: 790 RSSKKARPPKESA-------PSSGPPPKPPVSSGSGSSSSSSSCSSRKVKLQSKVA 838
S + R P +++ PS G S ++S ++ R SK+A
Sbjct: 660 SSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKATLPGERSSSSSSKLA 715
>gi|50962882 G patch domain containing 8 [Homo sapiens]
Length = 1502
Score = 82.8 bits (203), Expect = 2e-15
Identities = 132/607 (21%), Positives = 219/607 (36%), Gaps = 89/607 (14%)
Query: 483 RRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQPA 542
++K ++ +++++ + + A +G ++K+ +R+RK++ ++ A S G +P
Sbjct: 676 KKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKN-KSSAPADSERGPKPE 734
Query: 543 PPAPASPWDSKKHR------SRDRKPGSHASSSARRRSRSRSRSRSTRRRSR------ST 590
PP SP ++ R R P SS + S S+ R S+
Sbjct: 735 PPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSS 794
Query: 591 DRRRGGSRRSRSREKRRRRRRSASPPPATSSS----SSSRRERHRGKHRDGGGSKKKKKR 646
+RR G++RS SR R + S +SS S + + + GS+ + R
Sbjct: 795 CQRRAGTKRS-SRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSR 853
Query: 647 SRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTIT 706
SRS S S ++ + + S SC SR+R S D +D KR+
Sbjct: 854 SRSGRRHSSHRSSRRSYSSSSDASSDQSCY---SRQRSYSDDSYSDYSDRSRRHSKRSHD 910
Query: 707 VGRLDKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQKDRRRS---GAASSSSSS 763
D + + S S D LS + +S R RS G + SSS S
Sbjct: 911 SDDSDYASSKHRSKRHKYSSSD----DDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCS 966
Query: 764 REKGSRR-KALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSS 822
R + RR ++ R R RDR RS+ R P + + S G S
Sbjct: 967 RSRSKRRSRSTTAHSWQRSRSYSRDRSRST---RSPSQRSGSR--------KRSWGHESP 1015
Query: 823 SSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDER 882
S R+ ++SK+ S +P + G G R +S++ P +
Sbjct: 1016 EERHSGRRDFIRSKI-------YRSQSPHYFRSGRGEGPGKKDDGRGDDSKATG-PPSQN 1067
Query: 883 APTEMAKAAPGSTKPK-KTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVS 941
+ + + G P+ K V AK +K + K + KPS +
Sbjct: 1068 SNIGTGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSVS------------------ 1109
Query: 942 LKKSKADSCSQAAGTKGAEETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTVDSSCKT 1001
EE + + K+ P P P + + K
Sbjct: 1110 ------------------EEVQATPNKAGPKLKDPPQGYFGPKLPPSLGNKPVLPLIGKL 1151
Query: 1002 PEVSFLPEEATEEAGVRGGAEEEEEEEEEEEEEEEEE---EQQPATTTATSTAAAAPSTA 1058
P P + EE+G+ G E+E+ E EE + Q P+ T P +
Sbjct: 1152 PATR-KPNKKCEESGLERGEEQEQSETEEGPPGSSDALFGHQFPSEETTGPLLDPPPEES 1210
Query: 1059 PSAGSTA 1065
S +TA
Sbjct: 1211 KSGEATA 1217
Score = 70.5 bits (171), Expect = 1e-11
Identities = 157/679 (23%), Positives = 238/679 (35%), Gaps = 120/679 (17%)
Query: 515 TRKKSRRERKRSGEAKEAASSSS----GTQPAPPAPASPWDSKKH-RSRDRKPGSHASSS 569
+R K R K + + K+ SSS G P P + +K RS + + AS S
Sbjct: 579 SRNKDART-KGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGS 637
Query: 570 ARRRSRSR-------SRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPATSSS 622
A + S + T R S R G S R + ++K ++ + A +
Sbjct: 638 ACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEE 697
Query: 623 SSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGST--------- 673
SS+ E G SKK+KKR R + + + SE+ P P PP SGS
Sbjct: 698 KSSKAE-------SGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRA 750
Query: 674 --------------SCGDRDS-------------RRRGAVPPSI---QDLTDHDLFAIKR 703
S G +D + +G +PPS + T + R
Sbjct: 751 QDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHR 810
Query: 704 TITVGRLDKSDPRG------PSPAPASSPKREVLYDSEGLSGEERGGK--SSQKDRRRSG 755
+ + SD SP+ S + E SE R G+ SS + RRS
Sbjct: 811 SQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSY 870
Query: 756 AASSSSSSREK-GSRRKAL------DGGDRDRDRDR----DRDRDRSSKKARPPKESAPS 804
++SS +SS + SR+++ D DR R + D D +S K R + S
Sbjct: 871 SSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSS 930
Query: 805 SGPPPKPPVS-------------SGSGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPA 851
S S S S S SSSCS + K +S+ + S + +
Sbjct: 931 SDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSR-STTAHSWQRSRSYS 989
Query: 852 KDAASAGLGSIGVKFSRDRE--SRSPFLKPDERAPTEMAKAAPGSTKPKKTKVKAKAGAK 909
+D + + SR R SP + R +K + + + K
Sbjct: 990 RDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPGK 1049
Query: 910 KTKGTKGKTK---PSKTRKKVRSGGGSGGSGGQVSLKKSKADSCSQAAGTKGAEETSWSG 966
K G +K P + +G GS G A + ++ E
Sbjct: 1050 KDDGRGDDSKATGPPSQNSNIGTGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSVS 1109
Query: 967 EERAAKVPSTPPPKAAPPP-----PALTPDSQTVDSSCKTPEVSFLPEEATEEAGVRGGA 1021
EE A P+ PK PP P L P ++ + P + LP AT + +
Sbjct: 1110 EEVQA-TPNKAGPKLKDPPQGYFGPKLPP---SLGNKPVLPLIGKLP--ATRKPNKK--C 1161
Query: 1022 EEEEEEEEEEEEEEEEEEQQPATTTAT--STAAAAPSTAPSAGSTAGDSGAEDGPASRVS 1079
EE E EE+E+ E EE P ++ A + +T P +S + + A
Sbjct: 1162 EESGLERGEEQEQSETEEGPPGSSDALFGHQFPSEETTGPLLDPPPEESKSGEATADH-- 1219
Query: 1080 QLPTLPPPMPWNLPAGVDC 1098
P P PA DC
Sbjct: 1220 ------PVAPLGTPAHSDC 1232
Score = 35.0 bits (79), Expect = 0.47
Identities = 62/233 (26%), Positives = 95/233 (40%), Gaps = 32/233 (13%)
Query: 822 SSSSCSSRKVKLQSKVAVL---IREGVSS--TTPAKDAASAGLGSIGVKFSRDRESRSPF 876
S S VKL+S +V EG S T P + ++ GL +G D S
Sbjct: 301 SFSFAKKAPVKLESIASVFKDHAEEGTSEDGTKPDEKSSDQGLQKVG---DSDGSSNLDG 357
Query: 877 LKPDERAPTEMAKAAPGSTKPKKTKVKAKAGAKKTK------GTKGKTKPS-------KT 923
K DE P + A +K K+ K + AGA + + K KP+ +
Sbjct: 358 KKEDED-PQDGGSLASTLSKLKRMKREEGAGATEPEYYHYIPPAHCKVKPNFPFLLFMRA 416
Query: 924 RKKVRSGGGSGGSGGQVSLKKS--KADSCSQAAGTKGAEET----SWSGEERAAKVPSTP 977
+++ + S K S K SC +AA ++GAE+T S +E + PS P
Sbjct: 417 SEQMDGDNTTHPKNAPESKKGSSPKPKSCIKAAASQGAEKTVSEVSEQPKETSMTEPSEP 476
Query: 978 PPKAAPPPPALTPD--SQTVDS-SCKTPEVSFLPEEATEEAGVRGGAEEEEEE 1027
K A AL D Q+++S S K E +++E + A +E +E
Sbjct: 477 GSK-AEAKKALGGDVSDQSLESHSQKVSETQMCESNSSKETSLATPAGKESQE 528
Score = 33.5 bits (75), Expect = 1.4
Identities = 38/136 (27%), Positives = 49/136 (36%), Gaps = 38/136 (27%)
Query: 198 SPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFH----PTDEAYSPPP------APEQK 247
S +P+ S P P PP PAPP R D P +E S + Q
Sbjct: 721 SSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQD 780
Query: 248 YDPFEPTGSNPSSS----AGT-----------PSPEEEEEEEE-------------EEEE 279
+ + G P SS AGT PS +E+ ++ EEE
Sbjct: 781 HGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEE 840
Query: 280 EEEDEEEEEGLSQSIS 295
EEED E S+S S
Sbjct: 841 EEEDSGSEHSRSRSRS 856
>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
Length = 1512
Score = 82.0 bits (201), Expect = 3e-15
Identities = 160/658 (24%), Positives = 235/658 (35%), Gaps = 111/658 (16%)
Query: 381 PPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPTPAASATPTAQPLPQPPAPRA 440
PPLL P + + +++QP P L L PG AA AA+++ P P R
Sbjct: 37 PPLLLP----LLQPQLLQPPPPPPPLLFLAAPGTAAAAAAAAAASSSCFSPGPPLEVKRL 92
Query: 441 PEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGGLDLRRKILTQRRERYRQRS-- 498
G R GG RR+ +E ++R
Sbjct: 93 ARGK------------------------------RRAGGRQKRRRGPRAGQEAEKRRVFS 122
Query: 499 -PSPAPAPAPAAAAG----PPTRKKSRRERKRSG------EAKEAASSSSGTQPAPPAPA 547
P P A++G P + + G A AA+++ GT + +PA
Sbjct: 123 LPQPQQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGSPA 182
Query: 548 SPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRR 607
S +++ R GS RRS S RS+ R R D +RGGS S+SR +
Sbjct: 183 SSSGTQR-----RGEGSERRPRRDRRSSS-GRSKERHREHRRRDGQRGGSEASKSRSRHS 236
Query: 608 R-------------------RRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSR 648
RR+SAS ATSSSSSSR++R HR S K+ +
Sbjct: 237 HSGEERAEVAKSGSSSSSGGRRKSAS---ATSSSSSSRKDRDSKAHRSRTKSSKEPPSAY 293
Query: 649 SRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVG 708
K + + A S S G DS S++ +
Sbjct: 294 KEPPKAYREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSR 353
Query: 709 RLDKSDPRGPSPAPASSPKREVLYDSEGLSGEERGG-----KSSQKDRRRSGAASSSSSS 763
RL PR PSP S +R Y S ERGG S RRS + S
Sbjct: 354 RL----PRSPSP---YSRRRSPSYSRH--SSYERGGDVSPSPYSSSSWRRSRSPYSPVLR 404
Query: 764 REKGSRRKALDGGDRDRDRDRDR-DRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSS 822
R SR ++ R R R R R RS + P S + + + ++ +
Sbjct: 405 RSGKSRSRSPYSSRHSRSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEA 464
Query: 823 SSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDER 882
+ + + K +K A E + A + ++ G+ S S++ +K ++
Sbjct: 465 ARAAEAAKAAEATKAA----EAAAKAAKASNTSTPTKGNTETSAS---ASQTNHVKDVKK 517
Query: 883 APTEMAKAAPGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQ--- 939
E A + K K K K + TK T+K V G S + +
Sbjct: 518 IKIEHAPSPSSGGTLKNDKAKTKPPLQVTKVENNLIVDKATKKAVIVGKESKSAATKEES 577
Query: 940 VSLKKSKADSCSQAAGTKGAEETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTVDS 997
VSLK+ K + + G K E+ A V ST PP PP + P+ + DS
Sbjct: 578 VSLKE-KTKPLTPSIGAK-------EKEQHVALVTSTLPPLPLPP---MLPEDKEADS 624
Score = 76.3 bits (186), Expect = 2e-13
Identities = 166/693 (23%), Positives = 245/693 (35%), Gaps = 110/693 (15%)
Query: 478 GGLDLRRKILTQRRERYRQRSPSPAPAPAP-------AAAAGPPTRKKSRRERKRSGEAK 530
GGL K L +RR+R R SP P P PP + A
Sbjct: 13 GGLSWAEKKLEERRKRRRFLSPQQPPLLLPLLQPQLLQPPPPPPPLLFLAAPGTAAAAAA 72
Query: 531 EAASSSSGTQPAPPAPASPWDSKKHRS---RDRKPGSHASSSARRR-------------- 573
AA+SSS P PP K R+ + R+ G A A +R
Sbjct: 73 AAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRVFSLPQPQQDGGG 132
Query: 574 ------------------SRSR------SRSRSTRRRSRSTDRRRGGSRRSRSREKRRRR 609
S+S S +T + GGS S S +RR
Sbjct: 133 GASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGSPASSSGTQRRGE 192
Query: 610 RRSASPPPATSSSSSSRRERHR-GKHRDG--GGSKKKKKRSR--SRGEKR---------S 655
P SSS +ERHR + RDG GGS+ K RSR GE+R S
Sbjct: 193 GSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKSGSSS 252
Query: 656 GDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDP 715
G + A A S S+S DRDS+ + S ++ A K R DK++P
Sbjct: 253 SSGGRRKSASA-TSSSSSSRKDRDSKAHRSRTKSSKEPPS----AYKEPPKAYREDKTEP 307
Query: 716 RGPSPAPASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDG 775
+ + SP L + R +S + + S A SS + R +
Sbjct: 308 KAYRRRRSLSP----LGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYS 363
Query: 776 GDRDRDRDRDRDRDRSSKKARPPKESAP-SSGPPPKPPVSSGSGSSSSSSSCSSRKVKLQ 834
R R +R + P S+ P PV SG S S S SSR + +
Sbjct: 364 RRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSR 423
Query: 835 SKVAV-LIREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDERAPTEMAKAAPG 893
S+ + R SS +P+ + S+ + ++++++R+ + E AKAA
Sbjct: 424 SRHRLSRSRSRHSSISPSTLTLKS---SLAAELNKNKKARA----AEAARAAEAAKAAE- 475
Query: 894 STKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKKSKADSCSQA 953
+TK + KA + + TKG T+ S + + + +KK K +
Sbjct: 476 ATKAAEAAAKAAKASNTSTPTKGNTETSASASQ---------TNHVKDVKKIKIEH---- 522
Query: 954 AGTKGAEETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTVDSSCKTPEVSFLPEEATE 1013
A S G + K + PP + L D T + E AT+
Sbjct: 523 -----APSPSSGGTLKNDKAKTKPPLQVTKVENNLIVDKATKKAVIVGKESK---SAATK 574
Query: 1014 EAGVRGGAEEEEEEEEEEEEEEEEEEQQPATTTATSTAAAAPSTAP---SAGSTAGDSGA 1070
E V + +E+ + +E+EQ A T+T P P A S G+
Sbjct: 575 EESV---SLKEKTKPLTPSIGAKEKEQHVALVTSTLPPLPLPPMLPEDKEADSLRGNISV 631
Query: 1071 EDGPASRVSQLPTL--PPPMPWNLPAGVDCTTS 1101
+ +L L P+P LP G D + S
Sbjct: 632 KAVKKEVEKKLRCLLADLPLPPELPGGDDLSKS 664
>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
Length = 1452
Score = 82.0 bits (201), Expect = 3e-15
Identities = 160/658 (24%), Positives = 235/658 (35%), Gaps = 111/658 (16%)
Query: 381 PPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPTPAASATPTAQPLPQPPAPRA 440
PPLL P + + +++QP P L L PG AA AA+++ P P R
Sbjct: 37 PPLLLP----LLQPQLLQPPPPPPPLLFLAAPGTAAAAAAAAAASSSCFSPGPPLEVKRL 92
Query: 441 PEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGGLDLRRKILTQRRERYRQRS-- 498
G R GG RR+ +E ++R
Sbjct: 93 ARGK------------------------------RRAGGRQKRRRGPRAGQEAEKRRVFS 122
Query: 499 -PSPAPAPAPAAAAG----PPTRKKSRRERKRSG------EAKEAASSSSGTQPAPPAPA 547
P P A++G P + + G A AA+++ GT + +PA
Sbjct: 123 LPQPQQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGSPA 182
Query: 548 SPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRR 607
S +++ R GS RRS S RS+ R R D +RGGS S+SR +
Sbjct: 183 SSSGTQR-----RGEGSERRPRRDRRSSS-GRSKERHREHRRRDGQRGGSEASKSRSRHS 236
Query: 608 R-------------------RRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSR 648
RR+SAS ATSSSSSSR++R HR S K+ +
Sbjct: 237 HSGEERAEVAKSGSSSSSGGRRKSAS---ATSSSSSSRKDRDSKAHRSRTKSSKEPPSAY 293
Query: 649 SRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVG 708
K + + A S S G DS S++ +
Sbjct: 294 KEPPKAYREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSR 353
Query: 709 RLDKSDPRGPSPAPASSPKREVLYDSEGLSGEERGG-----KSSQKDRRRSGAASSSSSS 763
RL PR PSP S +R Y S ERGG S RRS + S
Sbjct: 354 RL----PRSPSP---YSRRRSPSYSRH--SSYERGGDVSPSPYSSSSWRRSRSPYSPVLR 404
Query: 764 REKGSRRKALDGGDRDRDRDRDR-DRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSS 822
R SR ++ R R R R R RS + P S + + + ++ +
Sbjct: 405 RSGKSRSRSPYSSRHSRSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEA 464
Query: 823 SSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDER 882
+ + + K +K A E + A + ++ G+ S S++ +K ++
Sbjct: 465 ARAAEAAKAAEATKAA----EAAAKAAKASNTSTPTKGNTETSAS---ASQTNHVKDVKK 517
Query: 883 APTEMAKAAPGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQ--- 939
E A + K K K K + TK T+K V G S + +
Sbjct: 518 IKIEHAPSPSSGGTLKNDKAKTKPPLQVTKVENNLIVDKATKKAVIVGKESKSAATKEES 577
Query: 940 VSLKKSKADSCSQAAGTKGAEETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTVDS 997
VSLK+ K + + G K E+ A V ST PP PP + P+ + DS
Sbjct: 578 VSLKE-KTKPLTPSIGAK-------EKEQHVALVTSTLPPLPLPP---MLPEDKEADS 624
Score = 76.3 bits (186), Expect = 2e-13
Identities = 166/693 (23%), Positives = 245/693 (35%), Gaps = 110/693 (15%)
Query: 478 GGLDLRRKILTQRRERYRQRSPSPAPAPAP-------AAAAGPPTRKKSRRERKRSGEAK 530
GGL K L +RR+R R SP P P PP + A
Sbjct: 13 GGLSWAEKKLEERRKRRRFLSPQQPPLLLPLLQPQLLQPPPPPPPLLFLAAPGTAAAAAA 72
Query: 531 EAASSSSGTQPAPPAPASPWDSKKHRS---RDRKPGSHASSSARRR-------------- 573
AA+SSS P PP K R+ + R+ G A A +R
Sbjct: 73 AAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRVFSLPQPQQDGGG 132
Query: 574 ------------------SRSR------SRSRSTRRRSRSTDRRRGGSRRSRSREKRRRR 609
S+S S +T + GGS S S +RR
Sbjct: 133 GASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGSPASSSGTQRRGE 192
Query: 610 RRSASPPPATSSSSSSRRERHR-GKHRDG--GGSKKKKKRSR--SRGEKR---------S 655
P SSS +ERHR + RDG GGS+ K RSR GE+R S
Sbjct: 193 GSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKSGSSS 252
Query: 656 GDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDP 715
G + A A S S+S DRDS+ + S ++ A K R DK++P
Sbjct: 253 SSGGRRKSASA-TSSSSSSRKDRDSKAHRSRTKSSKEPPS----AYKEPPKAYREDKTEP 307
Query: 716 RGPSPAPASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDG 775
+ + SP L + R +S + + S A SS + R +
Sbjct: 308 KAYRRRRSLSP----LGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYS 363
Query: 776 GDRDRDRDRDRDRDRSSKKARPPKESAP-SSGPPPKPPVSSGSGSSSSSSSCSSRKVKLQ 834
R R +R + P S+ P PV SG S S S SSR + +
Sbjct: 364 RRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSR 423
Query: 835 SKVAV-LIREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDERAPTEMAKAAPG 893
S+ + R SS +P+ + S+ + ++++++R+ + E AKAA
Sbjct: 424 SRHRLSRSRSRHSSISPSTLTLKS---SLAAELNKNKKARA----AEAARAAEAAKAAE- 475
Query: 894 STKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKKSKADSCSQA 953
+TK + KA + + TKG T+ S + + + +KK K +
Sbjct: 476 ATKAAEAAAKAAKASNTSTPTKGNTETSASASQ---------TNHVKDVKKIKIEH---- 522
Query: 954 AGTKGAEETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTVDSSCKTPEVSFLPEEATE 1013
A S G + K + PP + L D T + E AT+
Sbjct: 523 -----APSPSSGGTLKNDKAKTKPPLQVTKVENNLIVDKATKKAVIVGKESK---SAATK 574
Query: 1014 EAGVRGGAEEEEEEEEEEEEEEEEEEQQPATTTATSTAAAAPSTAP---SAGSTAGDSGA 1070
E V + +E+ + +E+EQ A T+T P P A S G+
Sbjct: 575 EESV---SLKEKTKPLTPSIGAKEKEQHVALVTSTLPPLPLPPMLPEDKEADSLRGNISV 631
Query: 1071 EDGPASRVSQLPTL--PPPMPWNLPAGVDCTTS 1101
+ +L L P+P LP G D + S
Sbjct: 632 KAVKKEVEKKLRCLLADLPLPPELPGGDDLSKS 664
>gi|133922600 splicing factor, arginine/serine-rich 16 [Homo
sapiens]
Length = 674
Score = 81.3 bits (199), Expect = 6e-15
Identities = 101/378 (26%), Positives = 151/378 (39%), Gaps = 54/378 (14%)
Query: 496 QRSPSPAPAPAPAAAAGP-PTRKK----------SRRERKRSGEAKEAASSSSGTQPAPP 544
+RSPS + + + + + P P R++ S E + A A+ ++G PAPP
Sbjct: 301 KRSPSESSSESRSRSRSPTPGREEKITFITSFGGSDEEAAAAAAAAAASGVTTGKPPAPP 360
Query: 545 APASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSRE 604
P P + +R R S +SSSA R S SRS SRS+ R RR GG RS
Sbjct: 361 QPGGPAPGRNASARRRSSSSSSSSSASRTSSSRSSSRSSSR-----SRRGGGYYRS---- 411
Query: 605 KRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPA 664
R R RS S + S S R R RG+ GGGS+ + SRS +R G G +
Sbjct: 412 GRHARSRSRSWSRSRSRSRRYSRSRSRGRRHSGGGSRDGHRYSRSPA-RRGGYGPRRRSR 470
Query: 665 PAPPPSGSTSCGDRDSRRRGA---------VPPSIQDLTDHDLFAIKRTITVGR-LDKSD 714
G R R + P + LT + + + R +S
Sbjct: 471 SRSHSGDRYRRGGRGLRHHSSSRSRSSWSLSPSRSRSLTRSRSHSPSPSQSRSRSRSRSQ 530
Query: 715 PRGPSPA------PASSPK-REVLYDSEGLSGEERGG---KSSQKDR---RRSGAASSSS 761
PSPA PA+SP E L +E +G+E G K + +++ R A +
Sbjct: 531 SPSPSPAREKLTRPAASPAVGEKLKKTEPAAGKETGAAKPKLTPQEKLKLRMQKALNRQF 590
Query: 762 SSREKGSRRKALDGGDRDRDRD----------RDRDRDRSSKKARPPKESAPSSGPPPKP 811
+ +K ++ K + ++R+ R ++R+R K+ + P P
Sbjct: 591 KADKKAAQEKMIQQEHERQEREDELRAMARKIRMKERERREKEREEWERQYSRQSRSPSP 650
Query: 812 PVSSGSGSSSSSSSCSSR 829
S SS S SR
Sbjct: 651 RYSREYSSSRRRSRSRSR 668
Score = 50.8 bits (120), Expect = 8e-06
Identities = 89/360 (24%), Positives = 119/360 (33%), Gaps = 39/360 (10%)
Query: 566 ASSSARRRSRSRSRSRSTRRRSR-----STDRRRGGS----RRSRSREKRRRRRRSASPP 616
A S RR R R R R R R S RR + +RS S R RS SP
Sbjct: 260 AMYSGRRSRRQRREFREKRLRGRKISPPSYARRDSPTYDPYKRSPSESSSESRSRSRSPT 319
Query: 617 PATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCG 676
P RE GGS ++ + + + G PAPP G + G
Sbjct: 320 PG--------REEKITFITSFGGSDEE---AAAAAAAAAASGVTTGKPPAPPQPGGPAPG 368
Query: 677 DRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEG 736
S RR + S + + + R + S A S R S
Sbjct: 369 RNASARRRSSSSSSSSSASRTSSSRSSSRSSSRSRRGGGYYRSGRHARSRSRSW---SRS 425
Query: 737 LSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDR------ 790
S R +S + RR SG S + R+ G R R R R DR
Sbjct: 426 RSRSRRYSRSRSRGRRHSGGGSRDGHRYSRSPARRG-GYGPRRRSRSRSHSGDRYRRGGR 484
Query: 791 -----SSKKARPPKESAPSSGPPPKPPVSSGSGSSSSSSSCSSRKVKLQSKVAVLIREGV 845
SS ++R +PS + S S S S S S S + + QS RE +
Sbjct: 485 GLRHHSSSRSRSSWSLSPSRS---RSLTRSRSHSPSPSQSRSRSRSRSQSPSPSPAREKL 541
Query: 846 SSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDERAPTEMAKAAPGSTKPKKTKVKAK 905
+ A A L ++ + P L P E+ M KA K K + K
Sbjct: 542 TRPA-ASPAVGEKLKKTEPAAGKETGAAKPKLTPQEKLKLRMQKALNRQFKADKKAAQEK 600
Score = 49.3 bits (116), Expect = 2e-05
Identities = 38/150 (25%), Positives = 59/150 (39%), Gaps = 4/150 (2%)
Query: 488 TQRRERYRQRSPSPAPAPA----PAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQPAP 543
+Q R R R RS SP+P+PA AA P +K ++ +G+ AA Q
Sbjct: 519 SQSRSRSRSRSQSPSPSPAREKLTRPAASPAVGEKLKKTEPAAGKETGAAKPKLTPQEKL 578
Query: 544 PAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSR 603
+++ ++ + R R+ R+ R +R R R
Sbjct: 579 KLRMQKALNRQFKADKKAAQEKMIQQEHERQEREDELRAMARKIRMKERERREKEREEWE 638
Query: 604 EKRRRRRRSASPPPATSSSSSSRRERHRGK 633
+ R+ RS SP + SSS RR R R +
Sbjct: 639 RQYSRQSRSPSPRYSREYSSSRRRSRSRSR 668
Score = 43.5 bits (101), Expect = 0.001
Identities = 45/194 (23%), Positives = 77/194 (39%), Gaps = 25/194 (12%)
Query: 748 QKDRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRD-RDRDRSSKKARPP---KESAP 803
+KD+ + A + + E+ KA+ G R R + R+ R++ +K PP + +P
Sbjct: 240 RKDKEEAEAIKHAKALEEE----KAMYSGRRSRRQRREFREKRLRGRKISPPSYARRDSP 295
Query: 804 SSGPPPKPPVSSGSGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIG 863
+ P + P S S S S S S + + + K+ + G S A AA+A +
Sbjct: 296 TYDPYKRSPSESSSESRSRSRSPTPGR---EEKITFITSFGGSDEEAAAAAAAAAASGVT 352
Query: 864 VKFSRDRESRSPFLKPDERAPTEMAKAAPGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKT 923
KP AP + APG + + + + + T S++
Sbjct: 353 TG------------KPP--APPQPGGPAPGRNASARRRSSSSSSSSSASRTSSSRSSSRS 398
Query: 924 RKKVRSGGGSGGSG 937
+ R GGG SG
Sbjct: 399 SSRSRRGGGYYRSG 412
Score = 33.1 bits (74), Expect = 1.8
Identities = 31/104 (29%), Positives = 39/104 (37%), Gaps = 11/104 (10%)
Query: 192 SASSSPSPSPS-------SSSPSPPPP----PPPPAPPAPPAPRFDIYDPFHPTDEAYSP 240
S S SPSPS S S SPSP P P A PA A P
Sbjct: 511 SRSHSPSPSQSRSRSRSRSQSPSPSPAREKLTRPAASPAVGEKLKKTEPAAGKETGAAKP 570
Query: 241 PPAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDE 284
P++K N A + +E+ ++E E +E EDE
Sbjct: 571 KLTPQEKLKLRMQKALNRQFKADKKAAQEKMIQQEHERQEREDE 614
>gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo
sapiens]
Length = 1031
Score = 80.5 bits (197), Expect = 1e-14
Identities = 57/147 (38%), Positives = 74/147 (50%), Gaps = 8/147 (5%)
Query: 517 KKSRRERKRSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHASSSA-RRRSR 575
++SR RKRS + S S P+ + D ++ RSRDR S S +RRSR
Sbjct: 3 RESRHYRKRSASRGRSGSRSRSRSPSDKR-SKRGDDRRSRSRDRDRRRERSRSRDKRRSR 61
Query: 576 SRSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRR-----RRSASPPPATSSSSSSRRERH 630
SR R R R RSR DR R RRSRSR++RR R RRS S P S + R R
Sbjct: 62 SRDRKRLRRSRSRERDRSR-ERRRSRSRDRRRSRSRSRGRRSRSSSPGNKSKKTENRSRS 120
Query: 631 RGKHRDGGGSKKKKKRSRSRGEKRSGD 657
+ K G SK+KKK + +++ D
Sbjct: 121 KEKTDGGESSKEKKKDKDDKEDEKEKD 147
Score = 62.0 bits (149), Expect = 4e-09
Identities = 43/116 (37%), Positives = 60/116 (51%), Gaps = 6/116 (5%)
Query: 571 RRRSRSRSRSRSTRRRSRSTDRR--RGGSRRSRSREKRRRRRRSASPPPATSSSSSSRR- 627
R+RS SR RS S R +D+R RG RRSRSR++ RRR RS S S S +R
Sbjct: 9 RKRSASRGRSGSRSRSRSPSDKRSKRGDDRRSRSRDRDRRRERSRSRDKRRSRSRDRKRL 68
Query: 628 ERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRR 683
R R + RD ++++RSRSR +RS S + + P + + SR +
Sbjct: 69 RRSRSRERD---RSRERRRSRSRDRRRSRSRSRGRRSRSSSPGNKSKKTENRSRSK 121
Score = 59.3 bits (142), Expect = 2e-08
Identities = 47/129 (36%), Positives = 65/129 (50%), Gaps = 20/129 (15%)
Query: 553 KKHRSRDRKPGSHASSSARRRSRSRSRSRSTR-----RRSRSTDRRRGGS-----RRSRS 602
++ R ++ S S +R RSRS S RS R RSR DRRR S RRSRS
Sbjct: 3 RESRHYRKRSASRGRSGSRSRSRSPSDKRSKRGDDRRSRSRDRDRRRERSRSRDKRRSRS 62
Query: 603 REKRR-RRRRSASPPPATSSSSSSRRERHRGKHRDGG--------GSKKKKKRSRSRGEK 653
R+++R RR RS + S R+R R + R G G+K KK +RSR ++
Sbjct: 63 RDRKRLRRSRSRERDRSRERRRSRSRDRRRSRSRSRGRRSRSSSPGNKSKKTENRSRSKE 122
Query: 654 RSGDGSEKA 662
++ DG E +
Sbjct: 123 KT-DGGESS 130
Score = 48.1 bits (113), Expect = 5e-05
Identities = 55/208 (26%), Positives = 81/208 (38%), Gaps = 27/208 (12%)
Query: 483 RRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSR-----RERKRSGEAKEAASSSS 537
R++ ++ R R RS SP+ + G R +SR RER RS + + + S
Sbjct: 9 RKRSASRGRSGSRSRSRSPSDK---RSKRGDDRRSRSRDRDRRRERSRSRDKRRSRSRDR 65
Query: 538 GTQPAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRS---RSRSTRRRSRSTDRRR 594
+ ++ RSR R S S RRSRS S +S+ T RSRS ++
Sbjct: 66 KRLRRSRSRERDRSRERRRSRSRDRRRSRSRSRGRRSRSSSPGNKSKKTENRSRSKEKTD 125
Query: 595 GG----SRRSRSREKRRRRRRSASPPPATSSSSSSR---------RERHRGKHRDGGGSK 641
GG ++ +K + + A R RE R K + G
Sbjct: 126 GGESSKEKKKDKDDKEDEKEKDAGNFDQNKLEEEMRKRKERVEKWREEQRKKAMENIGEL 185
Query: 642 KKKKRSRSRGEKRS---GDGSEKAPAPA 666
KK+ +G+K S D E PA A
Sbjct: 186 KKEIEEMKQGKKWSLEDDDDDEDDPAEA 213
Score = 45.8 bits (107), Expect = 3e-04
Identities = 42/152 (27%), Positives = 60/152 (39%), Gaps = 25/152 (16%)
Query: 702 KRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSS 761
KR+ + GR S R S +P+ D G++R +S +DRRR + S
Sbjct: 10 KRSASRGR---SGSRSRSRSPS---------DKRSKRGDDRRSRSRDRDRRRERSRSRDK 57
Query: 762 SSREKGSRRKALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSS 821
R++ R+RDR R+R R RS + R S G S S
Sbjct: 58 RRSRSRDRKRLRRSRSRERDRSRERRRSRSRDRRRSRSR-------------SRGRRSRS 104
Query: 822 SSSSCSSRKVKLQSKVAVLIREGVSSTTPAKD 853
SS S+K + +S+ G SS KD
Sbjct: 105 SSPGNKSKKTENRSRSKEKTDGGESSKEKKKD 136
Score = 39.7 bits (91), Expect = 0.019
Identities = 25/57 (43%), Positives = 30/57 (52%), Gaps = 1/57 (1%)
Query: 740 EERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDRSSKKAR 796
E R + R RSG+ S S S +K S+R D R RDRDR R+R RS K R
Sbjct: 4 ESRHYRKRSASRGRSGSRSRSRSPSDKRSKRGD-DRRSRSRDRDRRRERSRSRDKRR 59
Score = 36.6 bits (83), Expect = 0.16
Identities = 43/199 (21%), Positives = 71/199 (35%), Gaps = 31/199 (15%)
Query: 598 RRSRSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGD 657
+RS SR + R RS SP S RR R R + R ++++ RSR + RS D
Sbjct: 10 KRSASRGRSGSRSRSRSPSDKRSKRGDDRRSRSRDRDR-----RRERSRSRDKRRSRSRD 64
Query: 658 GSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRG 717
+ + S SR R R +S RG
Sbjct: 65 RKRLRRSRSRERDRSRERRRSRSRDR-------------------------RRSRSRSRG 99
Query: 718 PSPAPASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGS-RRKALDGG 776
+S + ++ S E+ G S K++++ ++ G+ + L+
Sbjct: 100 RRSRSSSPGNKSKKTENRSRSKEKTDGGESSKEKKKDKDDKEDEKEKDAGNFDQNKLEEE 159
Query: 777 DRDRDRDRDRDRDRSSKKA 795
R R ++ R+ KKA
Sbjct: 160 MRKRKERVEKWREEQRKKA 178
>gi|33356174 pinin, desmosome associated protein [Homo sapiens]
Length = 717
Score = 79.7 bits (195), Expect = 2e-14
Identities = 106/425 (24%), Positives = 159/425 (37%), Gaps = 42/425 (9%)
Query: 246 QKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISETLAGIY 305
Q+ + E TG+ + + EEEE+E + E E+EEE Q + E +
Sbjct: 314 QREEELEETGNQHNDVEIEEAGEEEEKEIAIVHSDAEKEQEEEEQKQEMEVKMEEETEVR 373
Query: 306 DDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGAM---RRRVFVVGTEAEAC 362
+ + D+QP + V AD + R V +E EA
Sbjct: 374 ESEK-----------QQDSQPEEVMDVLEMVENVKHVIADQEVMETNRVESVEPSENEAS 422
Query: 363 REGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPTPA 422
+E + +E L PG + ++ + EE + + P P
Sbjct: 423 KELEPEMEFEIEPDKECKS--LSPGKENVSALDMEKESEEKE---------EKESEPQPE 471
Query: 423 ASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGGLDL 482
A P QP QP + L S E + L P P + G L
Sbjct: 472 PVAQP--QPQSQPQLQLQSQSQPVLQSQPPSQPE---DLSLAVLQPTPQVTQEQ-GHLLP 525
Query: 483 RRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSR-RERKRSGEAKEAASSSSGTQP 541
RK + + P P + + TR +SR R R ++ +++ +SSSS +
Sbjct: 526 ERKDFPVESVKLTEVPVEPVLTVHPESKSKTKTRSRSRGRARNKTSKSRSRSSSSSSSSS 585
Query: 542 APPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSR 601
+ + +S S S R S +SS++ SR S S S+ SRS R RG +R +
Sbjct: 586 SSTSSSSGSSSSSGSSSSRSSSSSSSSTSGSSSRDSSSSTSSSSESRSRSRGRGHNRDRK 645
Query: 602 SREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRS---RSRGE-KRSGD 657
R R+RR TS S + G RD GSK K RS RS E RSG
Sbjct: 646 HRRSVDRKRRD------TSGLERSHKSSKGGSSRDTKGSKDKNSRSDRKRSISESSRSGK 699
Query: 658 GSEKA 662
S ++
Sbjct: 700 RSSRS 704
Score = 53.1 bits (126), Expect = 2e-06
Identities = 64/283 (22%), Positives = 104/283 (36%), Gaps = 43/283 (15%)
Query: 489 QRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQPAPPAPAS 548
++ E+ + P P P P + + +S+ + ++ S + QP P
Sbjct: 460 EKEEKESEPQPEPVAQPQPQSQPQLQLQSQSQPVLQSQPPSQPEDLSLAVLQPTPQVTQE 519
Query: 549 -----------PWDSKKHRSRDRKP--GSHASSSARRRSRSRSRSRSTRRRSRSTDRRRG 595
P +S K +P H S ++ ++RSRSR R+ + S+S R
Sbjct: 520 QGHLLPERKDFPVESVKLTEVPVEPVLTVHPESKSKTKTRSRSRGRARNKTSKSRSRSSS 579
Query: 596 GSRRSRSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRS 655
S S S S+S ++ SSSSS RD S SRSR R
Sbjct: 580 SSSSSSSSTSSSSGSSSSSGSSSSRSSSSSSSSTSGSSSRDSSSSTSSSSESRSRSRGRG 639
Query: 656 GDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKS-D 714
+RD + R +V D D ++R+ + S D
Sbjct: 640 --------------------HNRDRKHRRSV-----DRKRRDTSGLERSHKSSKGGSSRD 674
Query: 715 PRGPSPAPASSPKREVLYDS----EGLSGEERGGKSSQKDRRR 753
+G + S ++ + +S + S ER KS +KD+RR
Sbjct: 675 TKGSKDKNSRSDRKRSISESSRSGKRSSRSERDRKSDRKDKRR 717
Score = 49.3 bits (116), Expect = 2e-05
Identities = 48/177 (27%), Positives = 68/177 (38%), Gaps = 14/177 (7%)
Query: 620 SSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRD 679
S S + R R RG+ R+ K K RSRS S S + + + SGS+S
Sbjct: 552 SKSKTKTRSRSRGRARN----KTSKSRSRSSSSSSSSSSSTSSSSGSSSSSGSSSSRSSS 607
Query: 680 SRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLSG 739
S S +D + + + +S RG +R V SG
Sbjct: 608 SSSSSTSGSSSRDSSS--------STSSSSESRSRSRGRGHNRDRKHRRSVDRKRRDTSG 659
Query: 740 EERGGKSSQ--KDRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDRSSKK 794
ER KSS+ R G+ +S S K S ++ G R +RDR DR K+
Sbjct: 660 LERSHKSSKGGSSRDTKGSKDKNSRSDRKRSISESSRSGKRSSRSERDRKSDRKDKR 716
Score = 48.5 bits (114), Expect = 4e-05
Identities = 46/158 (29%), Positives = 70/158 (44%), Gaps = 17/158 (10%)
Query: 778 RDRDRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSSSSSCSSRKVKLQSKV 837
+ R R R R R+++SK + S+ SS SSGS SSS SSS S S
Sbjct: 557 KTRSRSRGRARNKTSKSRS--RSSSSSSSSSSSTSSSSGSSSSSGSSSSRSSSSSSSSTS 614
Query: 838 AVLIREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDERAPTEMAKAAPGSTKP 897
R+ SST+ + ++ S S G +RDR+ R R+ + G +
Sbjct: 615 GSSSRDSSSSTSSSSESRSR---SRGRGHNRDRKHR--------RSVDRKRRDTSGLERS 663
Query: 898 KKTKVKAKAGAKK-TKGTKGKTKPSKTRKKVRSGGGSG 934
K+ +K G+ + TKG+K K S ++ + SG
Sbjct: 664 HKS---SKGGSSRDTKGSKDKNSRSDRKRSISESSRSG 698
Score = 37.7 bits (86), Expect = 0.073
Identities = 39/156 (25%), Positives = 56/156 (35%), Gaps = 6/156 (3%)
Query: 703 RTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSS 762
R+ + GR + S + +SS S S G SS+ S + S SSS
Sbjct: 559 RSRSRGRARNKTSKSRSRSSSSSSSSSSSTSSSSGSSSSSGSSSSRSSSSSSSSTSGSSS 618
Query: 763 SREKGSRRKALDGGDRDRDRDRDRDRD--RSSKKARPPKESAPSSGPPPKPPVSSGSGSS 820
S + + R R R +RDR RS + R S K S + S
Sbjct: 619 RDSSSSTSSSSESRSRSRGRGHNRDRKHRRSVDRKRRDTSGLERSHKSSKGGSSRDTKGS 678
Query: 821 SSSSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAAS 856
+S S RK ++ R G S+ +D S
Sbjct: 679 KDKNSRSDRK----RSISESSRSGKRSSRSERDRKS 710
Score = 31.2 bits (69), Expect = 6.8
Identities = 15/33 (45%), Positives = 23/33 (69%)
Query: 1009 EEATEEAGVRGGAEEEEEEEEEEEEEEEEEEQQ 1041
EE E A V AE+E+EEEE+++E E + E++
Sbjct: 337 EEEKEIAIVHSDAEKEQEEEEQKQEMEVKMEEE 369
>gi|42741684 zinc finger protein 265 isoform 1 [Homo sapiens]
Length = 330
Score = 79.7 bits (195), Expect = 2e-14
Identities = 57/139 (41%), Positives = 74/139 (53%), Gaps = 21/139 (15%)
Query: 556 RSRDRKPGSHASSSARR------RSRSRSRSRST---RRRSRSTDRRRGGSRRSRSREKR 606
RSR + SH+ SS+R RSRSRSRSRS+ + RSRS+ R R SR S+SR
Sbjct: 201 RSRSKSRSSHSRSSSRSSSPSSSRSRSRSRSRSSSSSQSRSRSSSRERSRSRGSKSRSSS 260
Query: 607 RRRRRSASPPPAT--SSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPA 664
R R S+SP + SSSSS R R R + R +KK+R+RSR +R S
Sbjct: 261 RSHRGSSSPRKRSYSSSSSSPERNRKRSRSRSSSSGDRKKRRTRSRSPERRHRSS----- 315
Query: 665 PAPPPSGSTSCGDRDSRRR 683
SGS+ G R S ++
Sbjct: 316 -----SGSSHSGSRSSSKK 329
Score = 65.5 bits (158), Expect = 3e-10
Identities = 52/146 (35%), Positives = 69/146 (47%), Gaps = 23/146 (15%)
Query: 516 RKKSRRERKRSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHAS-----SSA 570
+KKS R + + + SSS + P+ S + RSR R S +S SS+
Sbjct: 195 KKKSNRRSRSKSRSSHSRSSSRSSSPS---------SSRSRSRSRSRSSSSSQSRSRSSS 245
Query: 571 RRRSRSR---SRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPATSSSSSSRR 627
R RSRSR SRS S R S+ R+R S S S E+ R+R RS S ++S RR
Sbjct: 246 RERSRSRGSKSRSSSRSHRGSSSPRKRSYSSSSSSPERNRKRSRSRS---SSSGDRKKRR 302
Query: 628 ERHRG---KHRDGGGSKKKKKRSRSR 650
R R +HR GS RS S+
Sbjct: 303 TRSRSPERRHRSSSGSSHSGSRSSSK 328
Score = 61.2 bits (147), Expect = 6e-09
Identities = 50/143 (34%), Positives = 74/143 (51%), Gaps = 11/143 (7%)
Query: 489 QRRERYRQRSPSPAPAPAPAAAAGPPTRKKSR-RERKRSGEAKEAAS-SSSGTQPAPPAP 546
+++ R RS S + ++ + P+ +SR R R RS + ++ S SSS +
Sbjct: 195 KKKSNRRSRSKSRSSHSRSSSRSSSPSSSRSRSRSRSRSSSSSQSRSRSSSRERSRSRGS 254
Query: 547 ASPWDSKKHR--SRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSRE 604
S S+ HR S RK +SSS+ R+R RSRSRS S S DR++ RR+RSR
Sbjct: 255 KSRSSSRSHRGSSSPRKRSYSSSSSSPERNRKRSRSRS----SSSGDRKK---RRTRSRS 307
Query: 605 KRRRRRRSASPPPATSSSSSSRR 627
RR R S+ + S SSS ++
Sbjct: 308 PERRHRSSSGSSHSGSRSSSKKK 330
Score = 53.5 bits (127), Expect = 1e-06
Identities = 39/131 (29%), Positives = 56/131 (42%), Gaps = 3/131 (2%)
Query: 702 KRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSS 761
+R+ + R S S +P+SS R S + R SS++ R G+ S SS
Sbjct: 200 RRSRSKSRSSHSRSSSRSSSPSSSRSRSRSRSRSSSSSQSRSRSSSRERSRSRGSKSRSS 259
Query: 762 SSREKGS---RRKALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSG 818
S +GS R+++ +R+R R R RSS K S P + SSGS
Sbjct: 260 SRSHRGSSSPRKRSYSSSSSSPERNRKRSRSRSSSSGDRKKRRTRSRSPERRHRSSSGSS 319
Query: 819 SSSSSSSCSSR 829
S S SS +
Sbjct: 320 HSGSRSSSKKK 330
Score = 43.5 bits (101), Expect = 0.001
Identities = 35/109 (32%), Positives = 44/109 (40%), Gaps = 10/109 (9%)
Query: 738 SGEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDRS-SKKAR 796
S KS R S +SS SSSR + R + R R R+R RS K+R
Sbjct: 198 SNRRSRSKSRSSHSRSSSRSSSPSSSRSRSRSRSRSSSSSQSRSRSSSRERSRSRGSKSR 257
Query: 797 PPKESAPSSGPPPKPPVSSGSGS---------SSSSSSCSSRKVKLQSK 836
S S P K SS S S S SSSS +K + +S+
Sbjct: 258 SSSRSHRGSSSPRKRSYSSSSSSPERNRKRSRSRSSSSGDRKKRRTRSR 306
Score = 41.6 bits (96), Expect = 0.005
Identities = 34/101 (33%), Positives = 41/101 (40%), Gaps = 9/101 (8%)
Query: 733 DSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSR---RKALDGGDRDRDRDRDRDRD 789
DS R S+ RS + SSS SS SR R + R R R+R R
Sbjct: 192 DSNKKKSNRRSRSKSRSSHSRSSSRSSSPSSSRSRSRSRSRSSSSSQSRSRSSSRERSRS 251
Query: 790 RSSKKARPPKESAPSSGPPPKPPVSSGSGSSSSSSSCSSRK 830
R SK + SS P + S SSSSSS +RK
Sbjct: 252 RGSKSRSSSRSHRGSSSPRKR------SYSSSSSSPERNRK 286
Score = 40.0 bits (92), Expect = 0.015
Identities = 34/106 (32%), Positives = 50/106 (47%), Gaps = 12/106 (11%)
Query: 488 TQRRERYRQRSPSPAPAPAPAAAA------GPPTRKKSRRERKRSGEAKEAASSSSGT-- 539
++ R R R RS S + + + +++ G +R SR R S K + SSSS +
Sbjct: 223 SRSRSRSRSRSSSSSQSRSRSSSRERSRSRGSKSRSSSRSHRGSSSPRKRSYSSSSSSPE 282
Query: 540 ---QPAPPAPASPWDSKKHRSRDRKPGS-HASSSARRRSRSRSRSR 581
+ + +S D KK R+R R P H SSS S SRS S+
Sbjct: 283 RNRKRSRSRSSSSGDRKKRRTRSRSPERRHRSSSGSSHSGSRSSSK 328
Score = 37.4 bits (85), Expect = 0.095
Identities = 60/239 (25%), Positives = 88/239 (36%), Gaps = 46/239 (19%)
Query: 712 KSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQK---DRRRSGAASSS---SSSRE 765
K RG + PAS K +SEG +E S K D A S +S E
Sbjct: 131 KKKYRGKAVGPASILKEVEDKESEGEEEDEDEDLSKYKLDEDEDEDDADLSKYNLDASEE 190
Query: 766 KGSRRKALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSSSSS 825
+ S +K + R R + RSS + S+PSS S S SSSS
Sbjct: 191 EDSNKK--------KSNRRSRSKSRSSHSRSSSRSSSPSSSR------SRSRSRSRSSSS 236
Query: 826 CSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDERAPT 885
SR S ++ + + S G S S R S SP +
Sbjct: 237 SQSR----------------SRSSSRERSRSRGSKSRSSSRSH-RGSSSP-----RKRSY 274
Query: 886 EMAKAAPGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKK 944
+ ++P + + + +G +K K +T+ ++ RS GS SG + S KK
Sbjct: 275 SSSSSSPERNRKRSRSRSSSSGDRK----KRRTRSRSPERRHRSSSGSSHSGSRSSSKK 329
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 79.3 bits (194), Expect = 2e-14
Identities = 127/579 (21%), Positives = 202/579 (34%), Gaps = 100/579 (17%)
Query: 521 RERKRSGEAKEAASSSSGTQPAPPAPA-----SPWDSKKHRSRDRKPGSHASSSARRRSR 575
R+ + S A + A ++ TQ A + S W K + +RK A+ ++++
Sbjct: 23 RDNQLSEVANKFAKATGATQQDANASSLLDIYSFW-LKSAKVPERK--LQANGPVAKKAK 79
Query: 576 SRSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPATSSSSSSRRERHRGKHR 635
++ S + S + +G + + +R S SSSS
Sbjct: 80 KKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESS------ 133
Query: 636 DGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTD 695
D + +KK+ +G K + A APP +S D DS P + +
Sbjct: 134 DDDDEEDQKKQPVQKGVK-----PQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKIT 188
Query: 696 HDLFAIKRTITVGRLDKSDPRGPSPAP-------ASSPKREVLYDSEGLSGEERGGKSSQ 748
+TV K+ P+ AP ASS S S EE+ + +
Sbjct: 189 --------PVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPK 240
Query: 749 KDRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPP 808
K + + + RK+ D D + ++ + +K P P S PP
Sbjct: 241 KTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPG-PYSSVPPPSAPP 299
Query: 809 PKP---------------PVSSGSGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPAKD 853
PK PV S SS S S S + K +K V + + PAK
Sbjct: 300 PKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVV--SKATTKPPPAKK 357
Query: 854 AASAGLGSIGVKFSRDRESRSPFLKPDERAPTEMAKAAPGSTKPKKTKVKAKAGAKKTKG 913
AA + S S D E+ P + A T + + K VK A K+ G
Sbjct: 358 AAESSSDSSDSDSSEDDEA------PSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVG 411
Query: 914 TKGKTKPSKTRKKVRSGGGSGGSGGQVSLKKSKADSCSQAAGTKGAEETSWSGEERAAKV 973
GGQ L + KADS S EE+S S EE+ K+
Sbjct: 412 -----------------------GGQKLLTR-KADSSSSE------EESSSSEEEKTKKM 441
Query: 974 PSTPPPKAAPPPPALTPDSQTVDSSCKTPEVSFLPEEATEEAGVRGGAEEEEEEEEEEEE 1033
+T PKA P Q S + S + EEEEE+ +
Sbjct: 442 VATTKPKATAKAALSLPAKQAPQGSRDSSSDS------------DSSSSEEEEEKTSKSA 489
Query: 1034 EEEEEEQQPATTTATSTAAAAPSTAPSAGSTAGDSGAED 1072
+++ ++ + A+A A S+ S++ D +E+
Sbjct: 490 VKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEE 528
Score = 75.9 bits (185), Expect = 2e-13
Identities = 82/336 (24%), Positives = 134/336 (39%), Gaps = 47/336 (13%)
Query: 766 KGSRRKALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSSSSS 825
K +++KA D + + + +KKA P A G PP + S SSSS S
Sbjct: 76 KKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVP---AKRVGLPPGKAAAKASESSSSEES 132
Query: 826 CSSRKVKLQSKVAVLIREGV-----SSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKP- 879
+ Q K V ++GV ++ P K A S+ S +++ P + P
Sbjct: 133 SDDDDEEDQKKQPV--QKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPV 190
Query: 880 ----DERAPTEMAKAAPGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGG 935
+AP + A+AAP K + + + + + K + T KK
Sbjct: 191 TVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKT-------- 242
Query: 936 SGGQVSLKKSKADSCSQAAGT----KGAEETSWSGEERAAKVP--STPPPKAAPPPPALT 989
V K+ A + +AA T + E S S EE K P + P P ++ PPP+
Sbjct: 243 ----VPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAP 298
Query: 990 PDSQTVDSSCKTPEVSFLPEEATEEAGVRGGAEEEEEEEEEEEEEEEEEEQQPATTTATS 1049
P +++ + P++A E+ E E+ +E + EEE++P T S
Sbjct: 299 PPKKSLGTQP--------PKKAVEKQQ----PVESSEDSSDESDSSSEEEKKPPTKAVVS 346
Query: 1050 TAAAAPSTAPSAGSTAGDSGAEDGPASRVSQLPTLP 1085
A P A A ++ DS D +S + P+ P
Sbjct: 347 KATTKPPPAKKAAESSSDS--SDSDSSEDDEAPSKP 380
Score = 71.6 bits (174), Expect = 5e-12
Identities = 123/579 (21%), Positives = 215/579 (37%), Gaps = 76/579 (13%)
Query: 502 APAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRK 561
A P A P KK+++ K S E +S PPA + +K R
Sbjct: 61 AKVPERKLQANGPVAKKAKK--KASSSDSEDSSEEEEEVQGPPAKKAAVPAK----RVGL 114
Query: 562 PGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPATSS 621
P A++ A S S S + + G + K ++ +S + SS
Sbjct: 115 PPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSS 174
Query: 622 SSSSRRERHRGKHRD---GGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDR 678
S + + K +K K +R+ + +G KA + + S S+S D
Sbjct: 175 SEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANG----KAASSSSSSSSSSSSDDS 230
Query: 679 DSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLS 738
+ + A P K+T+ ++ P A++P R+ + S
Sbjct: 231 EEEKAAATP--------------KKTVPKKQVVAKAP----VKAATTPTRKSSSSEDSSS 272
Query: 739 GEERGGKSSQKDRRRSGAA----SSSSSSREKGSR--RKALDGGDR-DRDRDRDRDRDRS 791
EE K K++ ++ S+ + G++ +KA++ + D + D S
Sbjct: 273 DEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSS 332
Query: 792 SKKARPPKESAPSSGPPPKPPVS--SGSGSSSSSSSCSSRKVKLQSKVAVLIREG----- 844
S++ + P A S KPP + + SS SS S SS + SK A +
Sbjct: 333 SEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPA 392
Query: 845 VSSTTPAKDAASAGLGSIG--VKFSRDRESRSPFLKPDERAPTEMAKAAPGSTKPKKTKV 902
V++ +PA A+A +G K + S + + E K +TKPK T
Sbjct: 393 VTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAK 452
Query: 903 KA-----------------KAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKKS 945
A + + ++ + KT S +KK + G S KK
Sbjct: 453 AALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKG 512
Query: 946 KADSCSQAAGTKGAEETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTVDSSCKTPEVS 1005
KA+S + ++ +EE EE K +P P+A P S + K + S
Sbjct: 513 KAESSNSSSSDDSSEE-----EEEKLKGKGSPRPQA----PKANGTSALTAQNGKAAKNS 563
Query: 1006 FLPEEATEEAGV---RGGAEEEEEEEEEEEEEEEEEEQQ 1041
EE ++A V + G+ ++ ++ E +E E + ++
Sbjct: 564 EEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKK 602
Score = 67.8 bits (164), Expect = 7e-11
Identities = 100/413 (24%), Positives = 158/413 (38%), Gaps = 75/413 (18%)
Query: 711 DKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRR 770
++ + +GP A+ P + V GL GK++ K S + SS E+ ++
Sbjct: 93 EEEEVQGPPAKKAAVPAKRV-----GLPP----GKAAAKASESSSSEESSDDDDEEDQKK 143
Query: 771 KALDGGDRD----------RDRDRDRDRDRSSKKARPPKESAPSSGP---------PPKP 811
+ + G + + + D D D SS+ PPK P P PPKP
Sbjct: 144 QPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSED-EPPKNQKPKITPVTVKAQTKAPPKP 202
Query: 812 P-----------VSSGSGSSSSSSSCSSRKVKLQSKVAVLI-REGVSSTTPAKDAASAGL 859
SS S SSSSSSS S + K + + ++ V + P K A +
Sbjct: 203 ARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTR 262
Query: 860 GSIGVKFSRDRESRSPFLKPDERAPTEMAKAAPGSTKPKKTKVKAKAGAKKTKGTKGKTK 919
S + S E KP + P + P S P K K+ GT+ K
Sbjct: 263 KSSSSEDSSSDEEEEQ-KKPMKNKPGPYSSVPPPSAPPPK----------KSLGTQPPKK 311
Query: 920 PSKTRKKVRSGGGSGGSGGQVSLKKSKADSCSQAA--------GTKGAEETSWSGEERAA 971
+ ++ V S S S ++ K + + + K AE +S S + ++
Sbjct: 312 AVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSS 371
Query: 972 KVPSTPPPKAAPPPPALTPDSQTVDSSCKTPEVSFLPEEATEEAGVRGG-------AEEE 1024
+ AP PA T + + + T + P A ++ V GG A+
Sbjct: 372 E------DDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQP-VGGGQKLLTRKADSS 424
Query: 1025 EEEEEEEEEEEEEEEQQPATTTATSTAAAAPS-TAPSAGSTAGDSGAEDGPAS 1076
EEE EEE+ ++ ATT +TA AA S A A + DS ++ +S
Sbjct: 425 SSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSS 477
Score = 64.3 bits (155), Expect = 7e-10
Identities = 93/497 (18%), Positives = 186/497 (37%), Gaps = 67/497 (13%)
Query: 190 PSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEAYSPPPAPEQKYD 249
P A SS S S SSS PP P P T +A + P +
Sbjct: 161 PKKAKSSDSDSDSSSEDEPPKNQKPKITPV--------------TVKAQTKAPPKPARAA 206
Query: 250 PFEPTG--SNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISET---LAGI 304
P G ++ SSS+ + S ++ EEE+ ++ +++ ++++ + + T +
Sbjct: 207 PKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSS 266
Query: 305 YDDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRAD---GAMRRRVFVVGTE--- 358
+D+S ++ + + P P P PP S A+ ++ V +E
Sbjct: 267 SEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSS 326
Query: 359 ----AEACREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGG 414
+ + E K + V + PPP +S + + E++ + +P G
Sbjct: 327 DESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPS----KPAG 382
Query: 415 RAARPTPAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAAD 474
+ + T + + AP+ P G L ++D + + +
Sbjct: 383 TTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEE-------------E 429
Query: 475 SRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAAS 534
S + +K++ + ++ + A PA A +R S S E +E +
Sbjct: 430 SSSSEEEKTKKMVATT----KPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKT 485
Query: 535 SSSGTQPAP------PAPASPWDSKKHRSRDRKPGSHASSS----ARRRSRSRSRSRSTR 584
S S + P AP+ P +KK ++ S SS + + + R ++ +
Sbjct: 486 SKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPK 545
Query: 585 RRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKK 644
S + G + +++ E+ ++ A+ + S S R++ K + +KK K
Sbjct: 546 ANGTSALTAQNG-KAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIK 604
Query: 645 KRS------RSRGEKRS 655
++ R +GEKR+
Sbjct: 605 LQTPNTFPKRKKGEKRA 621
Score = 58.9 bits (141), Expect = 3e-08
Identities = 100/518 (19%), Positives = 179/518 (34%), Gaps = 64/518 (12%)
Query: 183 GPAPPPAPSSASSSPSPSPSSSSPS-PPPPPPPPAPPA-----PPAPRFDIYDPFHPTDE 236
GP A ASSS S S PP A PA PP ++E
Sbjct: 72 GPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEE 131
Query: 237 AYSPPPAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGL------ 290
+ +QK P + G P + A P++ + + + + EDE +
Sbjct: 132 SSDDDDEEDQKKQPVQ-KGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPV 190
Query: 291 ------------SQSISRISETLAGIYDDNSLSQDFPGD-ESPRPDAQPTQPTPAPGTPP 337
+++ +I+ A +S S D E + A P + P
Sbjct: 191 TVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVA 250
Query: 338 QVDSTRADGAMRRRVFVVGTEAEACREGKVSVEVVTAGGAALPPPLLPPGDSEI------ 391
+ A R+ + ++ E K ++ +++PPP PP +
Sbjct: 251 KAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPK 310
Query: 392 EEGEIVQPEEEPRLALSLFRPGGRAAR--PTPAASATPTAQPLPQPPAPRAPEGDDFLSL 449
+ E QP E + + PT A + T +P PPA +A E S
Sbjct: 311 KAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKP---PPAKKAAESS---SD 364
Query: 450 HAESDGEGALQVDLGEPAPAPPAADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAA 509
++SD + AP+ PA ++ + + +SP+ PA AP
Sbjct: 365 SSDSDSSE------DDEAPSKPAGTTK----------NSSNKPAVTTKSPAVKPAAAPKQ 408
Query: 510 AAGPPTRKKSRRERKRSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHASSS 569
G + +R+ S E + ++S T+ +K S K S
Sbjct: 409 PVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRD 468
Query: 570 ARRRSRSRSRSRSTRRRSRSTDRRR-----GGSRRSRSREKRRRRRRSASPPPATSSSSS 624
+ S S S + S+S +++ GG+ S+ ++ + S++ ++SS S
Sbjct: 469 SSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSN---SSSSDDS 525
Query: 625 SRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKA 662
S E + K + + K S ++G ++ +
Sbjct: 526 SEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNS 563
Score = 54.7 bits (130), Expect = 6e-07
Identities = 112/623 (17%), Positives = 205/623 (32%), Gaps = 74/623 (11%)
Query: 244 PEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEE----EEEEDEEEEEGL--SQSISRI 297
PE+K P A + E+ EEEEE + ++ + GL ++ ++
Sbjct: 64 PERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKA 123
Query: 298 SETLAGIYDDNSLSQDFPGDESPRPDAQPTQPTP--APGTPPQVDSTRADGAMRRRVFVV 355
SE+ + + S D D+ +P + +P A P + S+ +D
Sbjct: 124 SESSSS---EESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDS------- 173
Query: 356 GTEAEACREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGR 415
+E E + K + VT PP +I G+ + S
Sbjct: 174 SSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEE 233
Query: 416 AARPTPAASATPTAQPLPQPPAPRA--PEGDDFLSLHAESDGEGALQVDLGEPAPAPPAA 473
A TP + P Q + + P A P S + SD E
Sbjct: 234 KAAATPKKTV-PKKQVVAKAPVKAATTPTRKSSSSEDSSSDEE----------------- 275
Query: 474 DSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAA 533
+ ++K + + Y P AP P + PP + +++ S E
Sbjct: 276 -------EEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDE 328
Query: 534 SSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRR 593
S SS + P P + ++ + P + ++ + S S S+
Sbjct: 329 SDSSSEEEKKP----PTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTT 384
Query: 594 RGGSRRSRSREKRRRRRRSASP--PPATSSSSSSRRERHRGKHRDGGGS--KKKKKRSRS 649
+ S + K + +A+P P +R+ + S +K KK +
Sbjct: 385 KNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVAT 444
Query: 650 RGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGR 709
K + + PA P S D DS + ++ T K G
Sbjct: 445 TKPKATAKAALSLPAKQAPQGSRDSSSDSDS----SSSEEEEEKTSKSAVKKKPQKVAGG 500
Query: 710 LDKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQKDR-----------RRSGAAS 758
S P A S DS E+ GK S + + ++G A+
Sbjct: 501 AAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAA 560
Query: 759 SSSSSREKGSRRKAL---DGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSS 815
+S E+ ++ A+ G + + + ++ + +A+ K P++ P K
Sbjct: 561 KNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRK---KG 617
Query: 816 GSGSSSSSSSCSSRKVKLQSKVA 838
+SS ++++ S+VA
Sbjct: 618 EKRASSPFRRVREEEIEVDSRVA 640
Score = 51.2 bits (121), Expect = 6e-06
Identities = 89/415 (21%), Positives = 136/415 (32%), Gaps = 54/415 (13%)
Query: 188 PAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEAYSPPPAPEQK 247
P P S+ PS P S PP P D D + E P
Sbjct: 286 PGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKP------ 339
Query: 248 YDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISETLAGIYDD 307
PT + S + P P ++ E + + + E++E S+
Sbjct: 340 -----PTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTK--------- 385
Query: 308 NSLSQDFPGDESP--RPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAEACREG 365
NS ++ +SP +P A P QP G ++ + +AD + E + +
Sbjct: 386 NSSNKPAVTTKSPAVKPAAAPKQPV---GGGQKLLTRKADSSSSEEESSSSEEEKTKKMV 442
Query: 366 KVSVEVVTAGGA-ALPPPLLPPG--DSEIEEGEIVQPEEEPRLALSLFRPGGRAARPTPA 422
+ TA A +LP P G DS + EEE + + S A + P
Sbjct: 443 ATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKS-------AVKKKPQ 495
Query: 423 ASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGGLDL 482
A A P E + S S+ E G P P P A+
Sbjct: 496 KVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANG------- 548
Query: 483 RRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQPA 542
LT + + + S AA ++ S ++RK++ AKEA + +
Sbjct: 549 -TSALTAQNGKAAKNSEEEEEEKKKAAVV--VSKSGSLKKRKQNEAAKEAETPQAKKIKL 605
Query: 543 PPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGS 597
P RK G +SS RR R +R S D +RG +
Sbjct: 606 QTPNTFP---------KRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAKRGAA 651
Score = 48.9 bits (115), Expect = 3e-05
Identities = 82/414 (19%), Positives = 142/414 (34%), Gaps = 56/414 (13%)
Query: 199 PSPSSSSPSPPPPPPPPA-PPAPPAPRFDIYDPFHPTDEAYSPPPAPEQKYDPFEPTGSN 257
P P SS P P PPP + PP + P ++++ + ++ + PT +
Sbjct: 286 PGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEE-EKKPPTKAV 344
Query: 258 PSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISETLAGIYDDNSLSQDFPGD 317
S + P P ++ E + + + E++E S+ NS ++
Sbjct: 345 VSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTK---------NSSNKPAVTT 395
Query: 318 ESP--RPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAEACREGKVSVEVVTAG 375
+SP +P A P QP G ++ + +AD + E + + + TA
Sbjct: 396 KSPAVKPAAAPKQPV---GGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAK 452
Query: 376 GA-ALPPPLLPPG--DSEIEEGEIVQPEEEPRLALSLFRP-----GGRAARPTPAASATP 427
A +LP P G DS + EEE + + S + G AA PA++
Sbjct: 453 AALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKG 512
Query: 428 TAQPLPQP------------------PAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPA 469
A+ P P+AP+ + +L A++ + E
Sbjct: 513 KAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKK 572
Query: 470 PPAADSRWGGLDLRR--------------KILTQRRERYRQRSPSPAPAPAPAAAAGPPT 515
S+ G L R+ KI Q + +R A +P
Sbjct: 573 AAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEE 632
Query: 516 RKKSRRERKRSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHASSS 569
+ R S +AK A+ G + + S +H +K GS+ S
Sbjct: 633 IEVDSRVADNSFDAKRGAAGDWGERANQVLKFTKGKSFRHEKTKKKRGSYRGGS 686
Score = 39.3 bits (90), Expect = 0.025
Identities = 41/165 (24%), Positives = 69/165 (41%), Gaps = 21/165 (12%)
Query: 939 QVSLKKSKADSCSQAAGTKGAEETSWSGEERAAKVP-----STPPPKAAPPPPALTPDSQ 993
+V+ K +KA +Q + +S ++AKVP + P A + DS+
Sbjct: 29 EVANKFAKATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPVAKKAKKKASSSDSE 88
Query: 994 TVDSSCKTPEVSFLPEEATEEAGVRGG----------AEEEEEEEEEEEEEEEEEEQQPA 1043
DSS + EV P + R G +E EE ++++EE++++QP
Sbjct: 89 --DSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPV 146
Query: 1044 T--TTATSTAAAAPSTAPSAGSTAGDSGAEDGPASRVSQLPTLPP 1086
+ AA AP + + DS +ED P +Q P + P
Sbjct: 147 QKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPK--NQKPKITP 189
>gi|186700623 Rab-like GTP-binding protein 1 isoform 1 [Homo
sapiens]
Length = 729
Score = 77.8 bits (190), Expect = 6e-14
Identities = 123/503 (24%), Positives = 176/503 (34%), Gaps = 101/503 (20%)
Query: 161 SPQSNSSRPTCARHLTLGTGDGGPAPP-PAPSSASSSPSPSPSSSSPSPPPPP--PPPAP 217
SP S P + TG P P PAP ++ +P SS P PP PPPA
Sbjct: 292 SPSPGSQSPVVPAG-AVSTGSSSPGTPQPAPQLPLNA---APPSSVPPVPPSEALPPPAC 347
Query: 218 PAPPAPRFDIYDPFH---PTDEAYSPPPAPE---------QKYDPFEPTGSNPSSSAGTP 265
P+ PAPR I P EA PPP P Q + F P S
Sbjct: 348 PSAPAPRRSIISRLFGTSPATEAAPPPPEPVPAAEGPATVQSVEDFVPDDRLDRSFLEDT 407
Query: 266 SPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISETLAGIYDDNSLSQDFPGDESPRPDAQ 325
+P +E++ + +++ + + E L + +AG DD L Q
Sbjct: 408 TPARDEKKVGAKAAQQDSDSDGEALGGN-----PMVAGFQDDVDLED------------Q 450
Query: 326 PTQPTPAPGTP-PQVDSTRADGAMRRRVFVVGTEAEACREGKVSVEVVTAGGAALPPPLL 384
P P P P P D T + +E EA V T G A P
Sbjct: 451 PRGSPPLPAGPVPSQDIT------------LSSEEEA------EVAAPTKGPAPAPQQCS 492
Query: 385 PPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPTPAASAT---PTAQPLPQPPAPRAP 441
P E + I P +PR + P AA P P + P + +PPA P
Sbjct: 493 EP---ETKWSSI--PASKPRRGTA---PTRTAAPPWPGGVSVRTGPEKRSSTRPPAEMEP 544
Query: 442 EGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGGLDLRRKI----LTQRRERYRQR 497
G + +ESD EG + + P +S G D +R+ +
Sbjct: 545 -GKGEQASSSESDPEGPIAAQMLSFVMDDPDFESE--GSDTQRRADDFPVRDDPSDVTDE 601
Query: 498 SPSPAPAPAPAAAAGPPTRKKSRRERKRSG--EAKEAASSSSGTQPAPPAPASPWDSKKH 555
PA P P P R K+ + G EA SS G + P SK+
Sbjct: 602 DEGPAEPPPPPKLPLPAFRLKNDSDLFGLGLEEAGPKESSEEGKEGKTP-------SKEK 654
Query: 556 RSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASP 615
+ + +K +A+++S+ + +S D+ G K RRRR P
Sbjct: 655 KKKKKKGKEEEEKAAKKKSKHK----------KSKDKEEG---------KEERRRRQQRP 695
Query: 616 PPATSSSSSSRRERHRGKHRDGG 638
P + +++ E G GG
Sbjct: 696 PRSRERTAADELEAFLGGGAPGG 718
Score = 42.4 bits (98), Expect = 0.003
Identities = 105/469 (22%), Positives = 160/469 (34%), Gaps = 65/469 (13%)
Query: 786 RDRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSSSSSCSSRKVKLQSKVAVLIREGV 845
R R +S A + +P S P P + +GSSS + + ++ L + +
Sbjct: 278 RSRGHASPLAANGQSPSPGSQSPVVPAGAVSTGSSSPGTPQPAPQLPLNAAPPSSVPPVP 337
Query: 846 SSTT---PAKDAASAGLGSIGVKFSRDRESRSPFLKPDERAPTEMAKAAPGSTKPKKTKV 902
S PA +A A SI + + P E P A P + + + V
Sbjct: 338 PSEALPPPACPSAPAPRRSIISRLFGTSPATEAAPPPPEPVP---AAEGPATVQSVEDFV 394
Query: 903 KAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKKSKADSCSQAAGTKGAEET 962
+ + T P++ KKV + K ++ DS S G
Sbjct: 395 PDD---RLDRSFLEDTTPARDEKKVGA-------------KAAQQDSDSDGEALGGNPMV 438
Query: 963 SWSGEERAAKVPSTPPPKAAPPPPALTPDSQTVDSSCKTPEVSFLPEEATEEAGVRGGAE 1022
+ ++ V P+ +PP PA SQ + S + EEA A +G A
Sbjct: 439 AGFQDD----VDLEDQPRGSPPLPAGPVPSQDITLSSE--------EEAEVAAPTKGPAP 486
Query: 1023 EEEEEEEEEEEEEEEEEQQPATTTATSTAAAAPSTAPSAGSTAGDSGAEDGPASRVSQLP 1082
++ E E + PA+ TA + P G + +G E ++R P
Sbjct: 487 APQQCSEPETKWSSI----PASKPRRGTAPTRTAAPPWPGGVSVRTGPEKRSSTRP---P 539
Query: 1083 TLPPPMPWNLPAGVDCTTSGVLALTALLFKMEEANLASRAKAQELIQATNQILSHRKPPS 1142
P + + G +A L F M++ + S Q R PS
Sbjct: 540 AEMEPGKGEQASSSESDPEGPIAAQMLSFVMDDPDFESEGSD---TQRRADDFPVRDDPS 596
Query: 1143 SL-----GMTPAPVPTSLGLPPGPSSYLLPGSLPLGGCGSTPPTPTGLAATSDKREGSSS 1197
+ G P P L LP ++ L L G G P SS
Sbjct: 597 DVTDEDEGPAEPPPPPKLPLP----AFRLKNDSDLFGLGLEEAGPK-----------ESS 641
Query: 1198 SEGR-GDTDKYLKKLHTQERAVEEVKLAIKPYYQKKDITKEEYKDILRK 1245
EG+ G T KK ++ EE K A K KK KEE K+ R+
Sbjct: 642 EEGKEGKTPSKEKKKKKKKGKEEEEKAAKKKSKHKKSKDKEEGKEERRR 690
Score = 37.4 bits (85), Expect = 0.095
Identities = 96/459 (20%), Positives = 153/459 (33%), Gaps = 88/459 (19%)
Query: 651 GEKRSGDGSEKAPAPAP-------PPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKR 703
G +G S P PAP PPS ++ PP+ I R
Sbjct: 305 GAVSTGSSSPGTPQPAPQLPLNAAPPSSVPPVPPSEA----LPPPACPSAPAPRRSIISR 360
Query: 704 TITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKS------SQKDRRRSGAA 757
++ P P P PA+ V E ++R +S +D ++ GA
Sbjct: 361 LFGTSPATEAAPPPPEPVPAAEGPATV-QSVEDFVPDDRLDRSFLEDTTPARDEKKVGAK 419
Query: 758 SSSSSSREKGSRRKALDG-----GDRDRDRDRDRDRDRSSKKARP-PKESAPSSGPPPKP 811
++ S G +AL G G +D D+ R A P P + S
Sbjct: 420 AAQQDSDSDG---EALGGNPMVAGFQDDVDLEDQPRGSPPLPAGPVPSQDITLSSEEEAE 476
Query: 812 PVSSGSGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFSRDRE 871
+ G + + CS + K S A R G T P + AA G + V+ E
Sbjct: 477 VAAPTKGPAPAPQQCSEPETKWSSIPASKPRRG---TAPTRTAAPPWPGGVSVRTGP--E 531
Query: 872 SRSPFLKPDERAPTEMAKAAPGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGG 931
RS P E P + +A+ + P+ + A+ + +++ S T+++
Sbjct: 532 KRSSTRPPAEMEPGKGEQASSSESDPEGP-IAAQMLSFVMDDPDFESEGSDTQRRA---- 586
Query: 932 GSGGSGGQVSLKKSKADSCSQAAGTKGAEETSWSGEERAAKVPSTPPPKAAPPPPALTPD 991
++ +D + G P+ PPP P PA
Sbjct: 587 ------DDFPVRDDPSDVTDEDEG------------------PAEPPPPPKLPLPAFRLK 622
Query: 992 SQTVDSSCKTPEVSFLPEEATEEAGVRG-------------GAEEEEE-----------E 1027
+ + E P+E++EE G G G EEEE+ +
Sbjct: 623 NDSDLFGLGLEEAG--PKESSEE-GKEGKTPSKEKKKKKKKGKEEEEKAAKKKSKHKKSK 679
Query: 1028 EEEEEEEEEEEEQQPATTTATSTAAAAPSTAPSAGSTAG 1066
++EE +EE QQ + TAA G+ G
Sbjct: 680 DKEEGKEERRRRQQRPPRSRERTAADELEAFLGGGAPGG 718
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 77.8 bits (190), Expect = 6e-14
Identities = 162/702 (23%), Positives = 249/702 (35%), Gaps = 129/702 (18%)
Query: 400 EEEPRLALSLFRPGGRAARPTPAASATPTAQPLPQPP-----APRAPEGDDFLSLHAESD 454
E PR L P AR P +P P P PP P P +A S
Sbjct: 2 ESGPRAELGAGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSS 61
Query: 455 GEGALQVDLGE----PAPAPPAADSRWGGLDLR---RKILTQRRERYRQRSPSPAPAPAP 507
+ L+ + P PAPP +S R + R R +RS P+P P
Sbjct: 62 KQLPLEPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVP 121
Query: 508 AAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHAS 567
A+ + PPT+++ ++ +R AKE + A A W K+ +++ +
Sbjct: 122 ASDS-PPTKQEVKKAGERHKLAKERREERAKYLAAKKA---VWLEKEEKAKALR---EKQ 174
Query: 568 SSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSR--------------EKRRRR---- 609
RRR R ++ +RR+ +R+R +++ R E R++R
Sbjct: 175 LQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWA 234
Query: 610 --RRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAP 667
+SP TS S S + KH D +K+ K S + S + S + A
Sbjct: 235 GALHHSSPGHKTSGSRCSVSAVNLPKHVDSIINKRLSKSSATLWNSPSRNRSLQLSA--- 291
Query: 668 PPSGSTSCGDR--------DSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPS 719
+S DR +R R AV R T GR S RGP
Sbjct: 292 ---WESSIVDRLMTPTLSFLARSRSAVTLPRNGRDQGRGCDPGRGPTWGRAGASLARGPQ 348
Query: 720 P-----------APASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGS 768
P P S+ + S S + +RR+ A S + R +
Sbjct: 349 PDRTHPSAAVPVCPRSASASPLTPCSVTRSVHRCAPAGERGERRKPNAGGSPAPVRRRPE 408
Query: 769 RRKALDGGDRDRDRDRDRD-----RDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSSS 823
+D++R+ +++ R+RS KK ++S P+S P+ +S+ + S S
Sbjct: 409 ASPVQKKEKKDKERENEKEKSALARERSLKK----RQSLPAS---PRARLSASTASELSP 461
Query: 824 SSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDERA 883
S K + S S PA S G G L P +
Sbjct: 462 KS----KARPSS-------PSTSWHRPASPCPSPGPGHT--------------LPPKPPS 496
Query: 884 PTEMAKAAPGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLK 943
P G+T K +V+ K AK++ G S+++ R S S
Sbjct: 497 PR-------GTTASPKGRVRRKEEAKESPSAAGPEDKSQSK---RRASNEKESAAPASPA 546
Query: 944 KSKADSCSQAAGTKGAEETSWSGEERAAKVPS-----TPPPKAAPPPPALTPDSQTVDSS 998
S A S + A K E+ A+ P+ T PP APP P + T D
Sbjct: 547 PSPAPSPTPAPPQK---------EQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDRE 597
Query: 999 CKTPEVSFLPEEATEEAGVRGGAEEEEEEEEEEEEEEEEEEQ 1040
E + L E +A + EE+E + E ++ EEQ
Sbjct: 598 ----EATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQ 635
Score = 61.2 bits (147), Expect = 6e-09
Identities = 90/435 (20%), Positives = 154/435 (35%), Gaps = 56/435 (12%)
Query: 503 PAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQPAPPA---PASPWDSKKHRSRD 559
P A A+ P + +S +GE E ++G PAP ASP K+ + ++
Sbjct: 362 PRSASASPLTPCSVTRSVHRCAPAGERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKE 421
Query: 560 RKPGSHASSSARRRSRSRSRSRSTRRRSR---STDRRRGGSRRSRSREKRRRRRRSASPP 616
R+ S+ AR RS + +S R+R ST ++R R ASP
Sbjct: 422 RENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWHRPASPC 481
Query: 617 PA-----------------TSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGS 659
P+ T+S R + K + K +S+ R +
Sbjct: 482 PSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAA 541
Query: 660 EKAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPS 719
+PAP+P PS + + ++ P + TD + + P PS
Sbjct: 542 PASPAPSPAPSPTPAPPQKEQ-------PPAETPTD-------AAVLTSPPAPAPPVTPS 587
Query: 720 PAPASSPKREVLYDSEGLSGEERGGKSSQKDR---RRSGAASSSSSSREKGSRRKALDGG 776
A + RE ++ L E+R Q++R R A RE+ R+A
Sbjct: 588 KPMAGTTDRE---EATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARA 644
Query: 777 DRDRDRDRDRDRDRSSKKARPPKE------------SAPSSGPPPKPPVSSGSGSSSSSS 824
+R+ + R R+ + +KA+ +E A S + +
Sbjct: 645 EREAEA-RRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQ 703
Query: 825 SCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDERAP 884
R+ +L+ + + VS T +D+ A + + E+RSP L+ +
Sbjct: 704 ERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQK 763
Query: 885 TEMAKAAPGSTKPKK 899
E P + P K
Sbjct: 764 EEPIPQEPQWSLPSK 778
Score = 55.8 bits (133), Expect = 3e-07
Identities = 60/255 (23%), Positives = 100/255 (39%), Gaps = 34/255 (13%)
Query: 412 PGGRAARPTPAASATPTAQPLPQP-------PAPRAPEGDDFLSLHAESDGEGALQVDLG 464
P +A +P+ S A P P P P P +P G A G + +
Sbjct: 461 PKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTT-----ASPKGRVRRKEEAK 515
Query: 465 E-PAPAPPAADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRER 523
E P+ A P S+ ++ + +E SP+P+PAP+P A PP +
Sbjct: 516 ESPSAAGPEDKSQ------SKRRASNEKESAAPASPAPSPAPSPTPA--PP--------Q 559
Query: 524 KRSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSR-SRSRSRS 582
K A+ ++ T P PAP + DR+ + + RR++R R R
Sbjct: 560 KEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQ 619
Query: 583 TRRRSRSTDRRRGGSRRSRSREKRRRRR---RSASPPPATSSSSSSRRERHR-GKHRDGG 638
RR D+R + +R E R R R A + + + E+ R K ++
Sbjct: 620 ERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEA 679
Query: 639 GSKKKKKRSRSRGEK 653
++ +++ R R E+
Sbjct: 680 EARSREEAERQRLER 694
Score = 52.8 bits (125), Expect = 2e-06
Identities = 44/148 (29%), Positives = 58/148 (39%), Gaps = 9/148 (6%)
Query: 139 PIPLPVPS-LLPRLRAWRTGKTVSPQSNSSRPTCARHLTLGTGDGGPAPPPAPSSASSSP 197
P P P P LP G T SP+ R A+ G + +S +
Sbjct: 480 PCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRAS-NEKE 538
Query: 198 SPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEA-YSPPPAPEQKYDPFEPTGS 256
S +P+S +PS P P P PAPP P + PTD A + PPAP P +P
Sbjct: 539 SAAPASPAPS-PAPSPTPAPPQKEQPPAET-----PTDAAVLTSPPAPAPPVTPSKPMAG 592
Query: 257 NPSSSAGTPSPEEEEEEEEEEEEEEEDE 284
T E+ + E+ E EE E
Sbjct: 593 TTDREEATRLLAEKRRQAREQREREEQE 620
Score = 43.9 bits (102), Expect = 0.001
Identities = 53/214 (24%), Positives = 77/214 (35%), Gaps = 52/214 (24%)
Query: 163 QSNSSRPTCARHLTLGTGDGGPAPPPAPSSASSSPSPSPSSSS-----------PSPPPP 211
++ + AR +L PA P A SAS++ SP S + P+ P P
Sbjct: 423 ENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWHRPASPCP 482
Query: 212 PPPPA---PPAPPAPRFDIYDP---FHPTDEAYSPPPA--PEQKYD-----PFEPTGSNP 258
P P PP PP+PR P +EA P A PE K E + P
Sbjct: 483 SPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAP 542
Query: 259 SSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISETLAGIYDDNSLSQDFPGDE 318
+S A +P+P ++E+ E + L+
Sbjct: 543 ASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLT--------------------------- 575
Query: 319 SPRPDAQPTQPT-PAPGTPPQVDSTRADGAMRRR 351
SP A P P+ P GT + ++TR RR+
Sbjct: 576 SPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQ 609
Score = 43.5 bits (101), Expect = 0.001
Identities = 33/101 (32%), Positives = 38/101 (37%), Gaps = 26/101 (25%)
Query: 182 GGPAPPPAPSSASSSPSPSPSSSSPSPPPPP-----PPPAPPAPPAPRFDIYDPFHPTDE 236
G APP + P PSP PSPPPPP P P PPA +
Sbjct: 10 GAGAPPAVVARTPPEPRPSPEGD-PSPPPPPMSALVPDTPPDTPPAMK------------ 56
Query: 237 AYSPPPAPEQKYDPFEPTGSNPSSSAG-TPSPEEEEEEEEE 276
A K P EP +PS G P+P +EE E
Sbjct: 57 -----NATSSKQLPLEP--ESPSGQVGPRPAPPQEESPSSE 90
Score = 40.0 bits (92), Expect = 0.015
Identities = 30/124 (24%), Positives = 47/124 (37%), Gaps = 15/124 (12%)
Query: 184 PAPPPAPSSASSSPSPSPSSSS--PSPPPPPPPPAPPAPPAPRFDIYDPF---------- 231
P+P PAP P+ +P+ ++ SPP P PP P P A D +
Sbjct: 551 PSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQA 610
Query: 232 ---HPTDEAYSPPPAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEE 288
+E A K E + A + EE+E E+ + ++EE+E
Sbjct: 611 REQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQE 670
Query: 289 GLSQ 292
L +
Sbjct: 671 RLQK 674
Score = 39.3 bits (90), Expect = 0.025
Identities = 31/118 (26%), Positives = 50/118 (42%), Gaps = 10/118 (8%)
Query: 181 DGGPAPPPAPSSA-----SSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTD 235
+G P+PPP P SA P+ +++ S P P +P PR P+
Sbjct: 30 EGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLPLEPESPSGQVGPRPAPPQEESPSS 89
Query: 236 EAYS---PPPA--PEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEE 288
EA S PPA P P + +P++ + SP ++E ++ E + +E E
Sbjct: 90 EAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKERRE 147
Score = 37.7 bits (86), Expect = 0.073
Identities = 29/96 (30%), Positives = 43/96 (44%), Gaps = 15/96 (15%)
Query: 135 GDRDPIPLPVPSLLPRLRAWRTGKTVSPQSNSSRPTCARHLTLG----TGDGGPAPPP-- 188
GD P P P+ +L+P T P ++ T ++ L L +G GP P P
Sbjct: 31 GDPSPPPPPMSALVPD-----TPPDTPPAMKNA--TSSKQLPLEPESPSGQVGPRPAPPQ 83
Query: 189 --APSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPA 222
+PSS + S P+P + P PP + P+P A
Sbjct: 84 EESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTA 119
Score = 33.1 bits (74), Expect = 1.8
Identities = 33/111 (29%), Positives = 44/111 (39%), Gaps = 13/111 (11%)
Query: 181 DGGPAPPPAPSSASSSPSPSPSSSSPS----PPPPPPPPAPPAPPAPRFDIYDPFHPTDE 236
D P PPA +A+SS SPS P P PP P+ A PT
Sbjct: 46 DTPPDTPPAMKNATSSKQLPLEPESPSGQVGPRPAPPQEESPSSEAKSRG------PTPP 99
Query: 237 AYSPPPA-PEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEE 286
A P A P ++ PT S S P+ +E ++ E + +E EE
Sbjct: 100 AMGPRDARPPRRSSQPSPTAVPASDS--PPTKQEVKKAGERHKLAKERREE 148
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.305 0.126 0.364
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 76,272,913
Number of Sequences: 37866
Number of extensions: 5582099
Number of successful extensions: 212330
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 2353
Number of HSP's successfully gapped in prelim test: 2546
Number of HSP's that attempted gapping in prelim test: 49657
Number of HSP's gapped (non-prelim): 86026
length of query: 1312
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1198
effective length of database: 13,930,794
effective search space: 16689091212
effective search space used: 16689091212
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.