Search of human proteins with 225637560

Search of human proteins with 225637560

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens]
         (645 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens]         1288   0.0  
gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens]         1083   0.0  
gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens]           932   0.0  
gi|148839316 NIMA-related kinase 4 [Homo sapiens]                     229   6e-60
gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]            220   3e-57
gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]            220   3e-57
gi|41872673 NIMA-related kinase 1 [Homo sapiens]                      220   3e-57
gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]           218   2e-56
gi|83627721 NIMA-related kinase 5 [Homo sapiens]                      214   3e-55
gi|4505373 NIMA-related kinase 2 [Homo sapiens]                       181   1e-45
gi|30039692 NIMA-related kinase 8 [Homo sapiens]                      176   6e-44
gi|19424132 NIMA-related kinase 7 [Homo sapiens]                      171   3e-42
gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]           167   3e-41
gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens]            167   3e-41
gi|222136641 NIMA-related kinase 9 [Homo sapiens]                     163   5e-40
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]       142   7e-34
gi|41281453 serine/threonine kinase 2 [Homo sapiens]                  140   4e-33
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]      139   6e-33
gi|93004081 polo-like kinase 2 [Homo sapiens]                         137   4e-32
gi|126362971 serine/threonine kinase 10 [Homo sapiens]                134   3e-31
gi|21359873 polo-like kinase 1 [Homo sapiens]                         132   8e-31
gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]              130   5e-30
gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]               130   5e-30
gi|217330634 serine/threonine kinase 36 [Homo sapiens]                129   6e-30
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo...   127   3e-29
gi|21361358 serine/threonine kinase 25 [Homo sapiens]                 127   3e-29
gi|41872374 polo-like kinase 3 [Homo sapiens]                         127   4e-29
gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Ho...   123   5e-28
gi|150456432 unc-51-like kinase 3 [Homo sapiens]                      123   6e-28
gi|153945765 mitogen-activated protein kinase kinase kinase 1 [H...   120   3e-27

>gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens]
          Length = 645

 Score = 1288 bits (3333), Expect = 0.0
 Identities = 645/645 (100%), Positives = 645/645 (100%)

Query: 1   MLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVL 60
           MLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVL
Sbjct: 1   MLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVL 60

Query: 61  KEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKI 120
           KEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKI
Sbjct: 61  KEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKI 120

Query: 121 QEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSR 180
           QEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSR
Sbjct: 121 QEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSR 180

Query: 181 LLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSI 240
           LLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSI
Sbjct: 181 LLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSI 240

Query: 241 VLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSE 300
           VLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSE
Sbjct: 241 VLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSE 300

Query: 301 MTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKL 360
           MTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKL
Sbjct: 301 MTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKL 360

Query: 361 KKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDE 420
           KKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDE
Sbjct: 361 KKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDE 420

Query: 421 ERWQGREEESDEPTLENLPESQPIPSMDLHELESIVEDATSDLGYHEIPEDPLVAEEYYA 480
           ERWQGREEESDEPTLENLPESQPIPSMDLHELESIVEDATSDLGYHEIPEDPLVAEEYYA
Sbjct: 421 ERWQGREEESDEPTLENLPESQPIPSMDLHELESIVEDATSDLGYHEIPEDPLVAEEYYA 480

Query: 481 DAFDSYCEESDEEEEEIALERPEKEIRNEGSQPAYRTNQQDSDIEALARCLENVLGCTSL 540
           DAFDSYCEESDEEEEEIALERPEKEIRNEGSQPAYRTNQQDSDIEALARCLENVLGCTSL
Sbjct: 481 DAFDSYCEESDEEEEEIALERPEKEIRNEGSQPAYRTNQQDSDIEALARCLENVLGCTSL 540

Query: 541 DTKTITTMAEDMSPGPPIFNSVMARTKMKRMRESAMQKLGTEVFEEVYNYLKRARHQNAS 600
           DTKTITTMAEDMSPGPPIFNSVMARTKMKRMRESAMQKLGTEVFEEVYNYLKRARHQNAS
Sbjct: 541 DTKTITTMAEDMSPGPPIFNSVMARTKMKRMRESAMQKLGTEVFEEVYNYLKRARHQNAS 600

Query: 601 EAEIRECLEKVVPQASDCFEVDQLLYFEEQLLITMGKEPTLQNHL 645
           EAEIRECLEKVVPQASDCFEVDQLLYFEEQLLITMGKEPTLQNHL
Sbjct: 601 EAEIRECLEKVVPQASDCFEVDQLLYFEEQLLITMGKEPTLQNHL 645


>gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens]
          Length = 599

 Score = 1083 bits (2800), Expect = 0.0
 Identities = 541/541 (100%), Positives = 541/541 (100%)

Query: 1   MLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVL 60
           MLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVL
Sbjct: 1   MLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVL 60

Query: 61  KEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKI 120
           KEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKI
Sbjct: 61  KEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKI 120

Query: 121 QEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSR 180
           QEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSR
Sbjct: 121 QEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSR 180

Query: 181 LLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSI 240
           LLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSI
Sbjct: 181 LLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSI 240

Query: 241 VLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSE 300
           VLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSE
Sbjct: 241 VLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSE 300

Query: 301 MTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKL 360
           MTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKL
Sbjct: 301 MTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKL 360

Query: 361 KKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDE 420
           KKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDE
Sbjct: 361 KKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDE 420

Query: 421 ERWQGREEESDEPTLENLPESQPIPSMDLHELESIVEDATSDLGYHEIPEDPLVAEEYYA 480
           ERWQGREEESDEPTLENLPESQPIPSMDLHELESIVEDATSDLGYHEIPEDPLVAEEYYA
Sbjct: 421 ERWQGREEESDEPTLENLPESQPIPSMDLHELESIVEDATSDLGYHEIPEDPLVAEEYYA 480

Query: 481 DAFDSYCEESDEEEEEIALERPEKEIRNEGSQPAYRTNQQDSDIEALARCLENVLGCTSL 540
           DAFDSYCEESDEEEEEIALERPEKEIRNEGSQPAYRTNQQDSDIEALARCLENVLGCTSL
Sbjct: 481 DAFDSYCEESDEEEEEIALERPEKEIRNEGSQPAYRTNQQDSDIEALARCLENVLGCTSL 540

Query: 541 D 541
           D
Sbjct: 541 D 541


>gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens]
          Length = 470

 Score =  932 bits (2408), Expect = 0.0
 Identities = 466/466 (100%), Positives = 466/466 (100%)

Query: 1   MLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVL 60
           MLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVL
Sbjct: 1   MLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVL 60

Query: 61  KEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKI 120
           KEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKI
Sbjct: 61  KEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKI 120

Query: 121 QEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSR 180
           QEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSR
Sbjct: 121 QEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSR 180

Query: 181 LLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSI 240
           LLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSI
Sbjct: 181 LLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSI 240

Query: 241 VLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSE 300
           VLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSE
Sbjct: 241 VLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSE 300

Query: 301 MTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKL 360
           MTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKL
Sbjct: 301 MTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKL 360

Query: 361 KKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDE 420
           KKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDE
Sbjct: 361 KKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDE 420

Query: 421 ERWQGREEESDEPTLENLPESQPIPSMDLHELESIVEDATSDLGYH 466
           ERWQGREEESDEPTLENLPESQPIPSMDLHELESIVEDATSDLGYH
Sbjct: 421 ERWQGREEESDEPTLENLPESQPIPSMDLHELESIVEDATSDLGYH 466


>gi|148839316 NIMA-related kinase 4 [Homo sapiens]
          Length = 841

 Score =  229 bits (584), Expect = 6e-60
 Identities = 114/265 (43%), Positives = 173/265 (65%), Gaps = 7/265 (2%)

Query: 29  YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDH 88
           Y   + +G GS+G V LV   K +R  +  V+K++++   +  E   A  EAQLLS+L H
Sbjct: 6   YCYLRVVGKGSYGEVTLV---KHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKH 62

Query: 89  PAIVKFHASFVEQDNFC-IITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVD 147
           P IV +  S+   D    I+  +CEG DL  K++E K  G++ PENQ++EWF+Q+ + + 
Sbjct: 63  PNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQK--GQLLPENQVVEWFVQIAMALQ 120

Query: 148 YMHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKH 206
           Y+HE+ ILHRDLK++NVFL + N++K+GD G++R+L   CD+A+TL GTP+YMSPE   +
Sbjct: 121 YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN 180

Query: 207 QGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES 266
           + Y+ KSD+W+L C +YEM  + HAF   +  S+V +I+EG  P +P  Y  EL  ++ +
Sbjct: 181 KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT 240

Query: 267 MLNKNPSLRPSAIEILKIPYLDEQL 291
           ML+K P  RPS   IL+ PY+  Q+
Sbjct: 241 MLSKRPEERPSVRSILRQPYIKRQI 265


>gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]
          Length = 506

 Score =  220 bits (561), Expect = 3e-57
 Identities = 128/367 (34%), Positives = 210/367 (57%), Gaps = 10/367 (2%)

Query: 29  YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDH 88
           Y++ + +G GSFG   LV  + +    ++  +KEI + +   N T  +  EA LL+K+ H
Sbjct: 4   YMVLRMIGEGSFGRALLVQHESSN---QMFAMKEIRLPKSFSN-TQNSRKEAVLLAKMKH 59

Query: 89  PAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDY 148
           P IV F  SF  + +  I+ EYC+G DL  KI++ K  GK+FPE+ I+ WF Q+ LGV++
Sbjct: 60  PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQK--GKLFPEDMILNWFTQMCLGVNH 117

Query: 149 MHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQ 207
           +H++R+LHRD+KSKN+FL +N  +K+GDFG +RLL      A T  GTP+Y+ PE  ++ 
Sbjct: 118 IHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENL 177

Query: 208 GYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESM 267
            Y+ KSDIWSL CILYE+C + H F  +++ +++LK+ +G    LP  Y  EL  +++ M
Sbjct: 178 PYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQM 237

Query: 268 LNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHL 327
             +NPS RPSA  +L    +   +Q  +     M   ++ L+  K + H  N  +K+ + 
Sbjct: 238 FKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKH--NTPRKKTNP 295

Query: 328 QTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEENSKRMQELRSRNFQQLS 387
             +R     +  T +E  + RK    D ++   + +VE      ++  +  +S + ++ S
Sbjct: 296 SRIRIALGNEASTVQEEEQDRKGSHTDLESIN-ENLVESALRRVNREEKGNKSVHLRKAS 354

Query: 388 VDVLHEK 394
              LH +
Sbjct: 355 SPNLHRR 361


>gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]
          Length = 506

 Score =  220 bits (561), Expect = 3e-57
 Identities = 128/367 (34%), Positives = 210/367 (57%), Gaps = 10/367 (2%)

Query: 29  YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDH 88
           Y++ + +G GSFG   LV  + +    ++  +KEI + +   N T  +  EA LL+K+ H
Sbjct: 4   YMVLRMIGEGSFGRALLVQHESSN---QMFAMKEIRLPKSFSN-TQNSRKEAVLLAKMKH 59

Query: 89  PAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDY 148
           P IV F  SF  + +  I+ EYC+G DL  KI++ K  GK+FPE+ I+ WF Q+ LGV++
Sbjct: 60  PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQK--GKLFPEDMILNWFTQMCLGVNH 117

Query: 149 MHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQ 207
           +H++R+LHRD+KSKN+FL +N  +K+GDFG +RLL      A T  GTP+Y+ PE  ++ 
Sbjct: 118 IHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENL 177

Query: 208 GYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESM 267
            Y+ KSDIWSL CILYE+C + H F  +++ +++LK+ +G    LP  Y  EL  +++ M
Sbjct: 178 PYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQM 237

Query: 268 LNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHL 327
             +NPS RPSA  +L    +   +Q  +     M   ++ L+  K + H  N  +K+ + 
Sbjct: 238 FKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKH--NTPRKKTNP 295

Query: 328 QTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEENSKRMQELRSRNFQQLS 387
             +R     +  T +E  + RK    D ++   + +VE      ++  +  +S + ++ S
Sbjct: 296 SRIRIALGNEASTVQEEEQDRKGSHTDLESIN-ENLVESALRRVNREEKGNKSVHLRKAS 354

Query: 388 VDVLHEK 394
              LH +
Sbjct: 355 SPNLHRR 361


>gi|41872673 NIMA-related kinase 1 [Homo sapiens]
          Length = 1258

 Score =  220 bits (561), Expect = 3e-57
 Identities = 104/269 (38%), Positives = 176/269 (65%), Gaps = 6/269 (2%)

Query: 28  RYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLD 87
           +YV  QK+G GSFG   LV  K  + G +  V+KEI++  ++  E  ++  E  +L+ + 
Sbjct: 3   KYVRLQKIGEGSFGKAILV--KSTEDGRQY-VIKEINISRMSSKEREESRREVAVLANMK 59

Query: 88  HPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVD 147
           HP IV++  SF E  +  I+ +YCEG DL  +I   K  G +F E+QI++WF+Q+ L + 
Sbjct: 60  HPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQK--GVLFQEDQILDWFVQICLALK 117

Query: 148 YMHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKH 206
           ++H+R+ILHRD+KS+N+FL K+  +++GDFG++R+L  + +LA T  GTP+Y+SPE  ++
Sbjct: 118 HVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICEN 177

Query: 207 QGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES 266
           + Y+ KSDIW+L C+LYE+C + HAF   +  ++VLKI+ G  P +   Y  +L +++  
Sbjct: 178 KPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQ 237

Query: 267 MLNKNPSLRPSAIEILKIPYLDEQLQNLM 295
           +  +NP  RPS   IL+  ++ ++++  +
Sbjct: 238 LFKRNPRDRPSVNSILEKGFIAKRIEKFL 266


>gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]
          Length = 489

 Score =  218 bits (554), Expect = 2e-56
 Identities = 114/283 (40%), Positives = 175/283 (61%), Gaps = 12/283 (4%)

Query: 29  YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDH 88
           Y++ + +G GSFG   LV  + +    ++  +KEI + +   N T  +  EA LL+K+ H
Sbjct: 4   YMVLRMIGEGSFGRALLVQHESSN---QMFAMKEIRLPKSFSN-TQNSRKEAVLLAKMKH 59

Query: 89  PAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDY 148
           P IV F  SF  + +  I+ EYC+G DL  KI++ K  GK+FPE+ I+ WF Q+ LGV++
Sbjct: 60  PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQK--GKLFPEDMILNWFTQMCLGVNH 117

Query: 149 MHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQ 207
           +H++R+LHRD+KSKN+FL +N  +K+GDFG +RLL      A T  GTP+Y+ PE  ++ 
Sbjct: 118 IHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENL 177

Query: 208 GYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESM 267
            Y+ KSDIWSL CILYE+C + H F  +++ +++LK+ +G    LP  Y  EL  +++ M
Sbjct: 178 PYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQM 237

Query: 268 LNKNPSLRPSAIEILKIPYLDEQLQ-----NLMCRYSEMTLED 305
             +NPS RPSA  +L    +   +Q      ++  Y E  LE+
Sbjct: 238 FKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEE 280


>gi|83627721 NIMA-related kinase 5 [Homo sapiens]
          Length = 708

 Score =  214 bits (544), Expect = 3e-55
 Identities = 109/273 (39%), Positives = 171/273 (62%), Gaps = 11/273 (4%)

Query: 28  RYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLD 87
           +Y + + +G G+FG  YL    K K   +  V+KEI+  ++   E   +  E  LL K+ 
Sbjct: 3   KYDVIKAIGQGAFGKAYLA---KGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMK 59

Query: 88  HPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVD 147
           HP IV F  SF E     I+ EYC+G DL  +I   +Q G +F E+QI+ WF+Q+ LG+ 
Sbjct: 60  HPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRIN--RQRGVLFSEDQILGWFVQISLGLK 117

Query: 148 YMHERRILHRDLKSKNVFLKNN--LLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALK 205
           ++H+R+ILHRD+K++N+FL  N  + K+GDFG++R+L  S +LA T  GTP+Y+SPE  +
Sbjct: 118 HIHDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQ 177

Query: 206 HQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIME 265
           ++ Y+ K+DIWSL C+LYE+C + H F G+N   +VLKI +     +   + +EL++++ 
Sbjct: 178 NKPYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLIS 237

Query: 266 SMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRY 298
            +   +P  RPS   ILK P+    L+NL+ +Y
Sbjct: 238 QLFQVSPRDRPSINSILKRPF----LENLIPKY 266


>gi|4505373 NIMA-related kinase 2 [Homo sapiens]
          Length = 445

 Score =  181 bits (460), Expect = 1e-45
 Identities = 134/419 (31%), Positives = 203/419 (48%), Gaps = 36/419 (8%)

Query: 26  ARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSK 85
           A  Y +   +G+GS+G    +   + K   ++ V KE+  G +   E      E  LL +
Sbjct: 5   AEDYEVLYTIGTGSYGRCQKI---RRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRE 61

Query: 86  LDHPAIVKFHASFVEQDN--FCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLL 143
           L HP IV+++   +++ N    I+ EYCEG DL   I +  +  +   E  ++    QL 
Sbjct: 62  LKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLT 121

Query: 144 LGVDYMHERR-----ILHRDLKSKNVFL--KNNLLKIGDFGVSRLLMGSCDLATTLTGTP 196
           L +   H R      +LHRDLK  NVFL  K N+ K+GDFG++R+L      A T  GTP
Sbjct: 122 LALKECHRRSDGGHTVLHRDLKPANVFLDGKQNV-KLGDFGLARILNHDTSFAKTFVGTP 180

Query: 197 HYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERY 256
           +YMSPE +    Y+ KSDIWSL C+LYE+C +   F   +   +  KI EG    +P RY
Sbjct: 181 YYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRY 240

Query: 257 PKELNAIMESMLNKNPSLRPSAIEILKIPYL-----DEQLQNLMCRYSEMTLEDKNLDCQ 311
             ELN I+  MLN     RPS  EIL+ P +     DEQ +NL  R  ++   +K+ D  
Sbjct: 241 SDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSS 300

Query: 312 KEAAHI-INAMQKRIHLQTLRALSE-----VQKMTPRERMRLRKLQAADEKARKLKKIVE 365
              + + +  +Q +   + L+A  E      Q++  RER+   KL  A+   +    + E
Sbjct: 301 PVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKE 360

Query: 366 EKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKE-----EQPEGRLSCSPQDED 419
            K+   +   + L       L   V+ +K H  G E KE     E  E +L+   + +D
Sbjct: 361 RKFLSLASNPELL------NLPSSVIKKKVHFSG-ESKENIMRSENSESQLTSKSKCKD 412


>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
          Length = 692

 Score =  176 bits (446), Expect = 6e-44
 Identities = 97/269 (36%), Positives = 158/269 (58%), Gaps = 8/269 (2%)

Query: 28  RYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLD 87
           +Y   + +G G+FG V+L      K  ++L ++K+I V ++   E   A  E Q+L  L+
Sbjct: 3   KYERIRVVGRGAFGIVHLCL---RKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLN 59

Query: 88  HPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVD 147
           HP +++++ +F+E     I  EY  G  L + IQ  K+   +  E  I+ +F+Q+LL + 
Sbjct: 60  HPNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQ--KRCNSLLEEETILHFFVQILLALH 117

Query: 148 YMHERRILHRDLKSKNVFLKNN--LLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALK 205
           ++H   ILHRDLK++N+ L  +  ++KIGDFG+S++L  S   A T+ GTP Y+SPE  +
Sbjct: 118 HVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKIL-SSKSKAYTVVGTPCYISPELCE 176

Query: 206 HQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIME 265
            + Y+ KSDIW+L C+LYE+  +  AF  +N  ++VLKI+ G    + +RY  EL  ++ 
Sbjct: 177 GKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVL 236

Query: 266 SMLNKNPSLRPSAIEILKIPYLDEQLQNL 294
           S+L+  P+ RP    I+  P     L NL
Sbjct: 237 SLLSLEPAQRPPLSHIMAQPLCIRALLNL 265


>gi|19424132 NIMA-related kinase 7 [Homo sapiens]
          Length = 302

 Score =  171 bits (432), Expect = 3e-42
 Identities = 90/260 (34%), Positives = 148/260 (56%), Gaps = 10/260 (3%)

Query: 31  LQQKLGSGSFGTVYLVSDKKAKRGEELKV-LKEISVGEL-NPNETVQANLEAQLLSKLDH 88
           +++K+G G F  VY    + A   + + V LK++ + +L +         E  LL +L+H
Sbjct: 36  IEKKIGRGQFSEVY----RAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNH 91

Query: 89  PAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDY 148
           P ++K++ASF+E +   I+ E  +  DL   I+ +K+  ++ PE  + ++F+QL   +++
Sbjct: 92  PNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEH 151

Query: 149 MHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQ 207
           MH RR++HRD+K  NVF+    ++K+GD G+ R        A +L GTP+YMSPE +   
Sbjct: 152 MHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHEN 211

Query: 208 GYDTKSDIWSLACILYEMCCMNHAFAGS--NFLSIVLKIVEGDTPSLP-ERYPKELNAIM 264
           GY+ KSDIWSL C+LYEM  +   F G   N  S+  KI + D P LP + Y +EL  ++
Sbjct: 212 GYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLV 271

Query: 265 ESMLNKNPSLRPSAIEILKI 284
              +N +P  RP    +  +
Sbjct: 272 NMCINPDPEKRPDVTYVYDV 291


>gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]
          Length = 347

 Score =  167 bits (423), Expect = 3e-41
 Identities = 95/269 (35%), Positives = 150/269 (55%), Gaps = 18/269 (6%)

Query: 20  YPKTLIAR----RYVLQQKLGSGSFGTVYLVS---DKKAKRGEELKVLKEISVGELNPNE 72
           +P TL  R     + +++K+G G F  VY  +   D+K         LK++ + E+   +
Sbjct: 66  HPNTLSFRCSLADFQIEKKIGRGQFSEVYKATCLLDRKTV------ALKKVQIFEMMDAK 119

Query: 73  TVQANL-EAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFP 131
             Q  + E  LL +L+HP I+K+  SF+E +   I+ E  +  DL   I+ +K+  ++ P
Sbjct: 120 ARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIP 179

Query: 132 ENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLAT 190
           E  + ++F+QL   V++MH RR++HRD+K  NVF+    ++K+GD G+ R        A 
Sbjct: 180 ERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAH 239

Query: 191 TLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGS--NFLSIVLKIVEGD 248
           +L GTP+YMSPE +   GY+ KSDIWSL C+LYEM  +   F G   N  S+  KI + D
Sbjct: 240 SLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCD 299

Query: 249 TPSLP-ERYPKELNAIMESMLNKNPSLRP 276
            P LP E Y ++L  ++   +  +P  RP
Sbjct: 300 YPPLPGEHYSEKLRELVSMCICPDPHQRP 328


>gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens]
          Length = 313

 Score =  167 bits (423), Expect = 3e-41
 Identities = 95/269 (35%), Positives = 150/269 (55%), Gaps = 18/269 (6%)

Query: 20  YPKTLIAR----RYVLQQKLGSGSFGTVYLVS---DKKAKRGEELKVLKEISVGELNPNE 72
           +P TL  R     + +++K+G G F  VY  +   D+K         LK++ + E+   +
Sbjct: 32  HPNTLSFRCSLADFQIEKKIGRGQFSEVYKATCLLDRKTV------ALKKVQIFEMMDAK 85

Query: 73  TVQANL-EAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFP 131
             Q  + E  LL +L+HP I+K+  SF+E +   I+ E  +  DL   I+ +K+  ++ P
Sbjct: 86  ARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIP 145

Query: 132 ENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLAT 190
           E  + ++F+QL   V++MH RR++HRD+K  NVF+    ++K+GD G+ R        A 
Sbjct: 146 ERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAH 205

Query: 191 TLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGS--NFLSIVLKIVEGD 248
           +L GTP+YMSPE +   GY+ KSDIWSL C+LYEM  +   F G   N  S+  KI + D
Sbjct: 206 SLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCD 265

Query: 249 TPSLP-ERYPKELNAIMESMLNKNPSLRP 276
            P LP E Y ++L  ++   +  +P  RP
Sbjct: 266 YPPLPGEHYSEKLRELVSMCICPDPHQRP 294


>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
          Length = 979

 Score =  163 bits (412), Expect = 5e-40
 Identities = 92/269 (34%), Positives = 155/269 (57%), Gaps = 8/269 (2%)

Query: 29  YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDH 88
           Y+  + LG G+FG   L    +    + L V KE+ +  L+  E   A  E  +L+ L H
Sbjct: 52  YIPIRVLGRGAFGEATLY---RRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQH 108

Query: 89  PAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDY 148
             I+ ++  F++     I  EYC G +L DKI   +Q  K+F E  ++ +  Q++  V  
Sbjct: 109 DNIIAYYNHFMDNTTLLIELEYCNGGNLYDKI--LRQKDKLFEEEMVVWYLFQIVSAVSC 166

Query: 149 MHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQ 207
           +H+  ILHRD+K+ N+FL K NL+K+GD+G+++ L     +A TL GTP+YMSPE  +  
Sbjct: 167 IHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGV 226

Query: 208 GYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPE--RYPKELNAIME 265
            Y+ KSDIW++ C+++E+  +   F  +N L++ +KIV+G      +  +Y  EL  ++ 
Sbjct: 227 KYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVH 286

Query: 266 SMLNKNPSLRPSAIEILKIPYLDEQLQNL 294
           S L+++P  RP+A E+L  P L ++ + +
Sbjct: 287 SCLDQDPEQRPTADELLDRPLLRKRRREM 315


>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
          Length = 443

 Score =  142 bits (359), Expect = 7e-34
 Identities = 92/308 (29%), Positives = 153/308 (49%), Gaps = 20/308 (6%)

Query: 13  GSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNE 72
           GST +   P+ L  +     +K+G GSFG V+   D + ++   +K++ ++   E   +E
Sbjct: 24  GSTNLKADPEELFTKL----EKIGKGSFGEVFKGIDNRTQKVVAIKII-DLEEAE---DE 75

Query: 73  TVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPE 132
                 E  +LS+ D P + K++ S+++     II EY  G    D ++          E
Sbjct: 76  IEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGP-----LDE 130

Query: 133 NQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATT 191
            QI     ++L G+DY+H  + +HRD+K+ NV L ++  +K+ DFGV+  L  +     T
Sbjct: 131 TQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNT 190

Query: 192 LTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPS 251
             GTP +M+PE +K   YD+K+DIWSL     E+       +  + + ++  I + + P+
Sbjct: 191 FVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPT 250

Query: 252 LPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYL------DEQLQNLMCRYSEMTLED 305
           L   Y K L   +E+ LNK PS RP+A E+LK  ++         L  L+ RY     E 
Sbjct: 251 LEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQ 310

Query: 306 KNLDCQKE 313
            + D   E
Sbjct: 311 SHDDSSSE 318


>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
          Length = 1235

 Score =  140 bits (353), Expect = 4e-33
 Identities = 134/532 (25%), Positives = 248/532 (46%), Gaps = 64/532 (12%)

Query: 34  KLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVK 93
           +LG G+FG VY   +K+       KV+   S  EL         +E  +L+  DHP IVK
Sbjct: 39  ELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELE-----DYMVEIDILASCDHPNIVK 93

Query: 94  FHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERR 153
              +F  ++N  I+ E+C G  +D  + E ++      E+QI     Q L  ++Y+H+ +
Sbjct: 94  LLDAFYYENNLWILIEFCAGGAVDAVMLELERP---LTESQIQVVCKQTLDALNYLHDNK 150

Query: 154 ILHRDLKSKNV-FLKNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEAL-----KHQ 207
           I+HRDLK+ N+ F  +  +K+ DFGVS     +     +  GTP++M+PE +     K +
Sbjct: 151 IIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDR 210

Query: 208 GYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSL--PERYPKELNAIME 265
            YD K+D+WSL   L EM  +       N + ++LKI + + P+L  P R+       ++
Sbjct: 211 PYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLK 270

Query: 266 SMLNKNPSLRPSAIEILKIPY--------LDEQLQNLMCRYSEMTLEDKNLDCQKEAAHI 317
             L KN   R +  ++L+ P+        + E +       +E   + K  D ++E  + 
Sbjct: 271 KCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGKEEDEEEETENS 330

Query: 318 IN-AMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEENSKRMQ 376
           +     KR       A SE  K++    +    L++  EK  +     E+K   NSK + 
Sbjct: 331 LPIPASKRASSDLSIASSEEDKLSQNACI----LESVSEKTERSNS--EDKL--NSKILN 382

Query: 377 ELRSRNFQQLSVDVLHE---KTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEP 433
           E  + +  + +V+ ++E      L+ M E  +    R +   ++E E+R          P
Sbjct: 383 EKPTTDEPEKAVEDINEHITDAQLEAMTELHD----RTAVIKENEREKR----------P 428

Query: 434 TLENLPESQPIPSMDLHELESIVEDATSDLGYHEIPEDPLVAEEYYADAFDSYCEESDEE 493
            LENLP+++   ++D++   S+ E   +++         ++  E   +      EE D+E
Sbjct: 429 KLENLPDTEDQETVDIN---SVSEGKENNI---------MITLETNIEHNLKSEEEKDQE 476

Query: 494 EEEIALER--PEKEIRNEGSQPAYRTNQQDSDIEALARCLENVLGCTSLDTK 543
           ++++   +    +EI++   Q     +Q+  + EA  + +++ +G T  DT+
Sbjct: 477 KQQMFENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQ 528



 Score = 34.7 bits (78), Expect = 0.28
 Identities = 46/206 (22%), Positives = 93/206 (45%), Gaps = 20/206 (9%)

Query: 252  LPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLED-KNLDC 310
            L ER+ +E + +++  L     ++    ++LK     E+    M RY++  +E+ KN   
Sbjct: 1011 LEERHLQEKHQLLKQQLKDQYFMQRH--QLLK---RHEKETEQMQRYNQRLIEELKNRQT 1065

Query: 311  QKEAA--HIINAMQKRIHLQTLRALSEVQKMTP-RERMRLRKLQAADEKARKLKKIVEEK 367
            Q+ A    I  +  K       ++L      TP ++R ++++  A +EK +K +++ + +
Sbjct: 1066 QERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQ 1125

Query: 368  YEENSKR---------MQELRSRNFQQLSVDVLHEKTHLKGMEEK--EEQPEGRLSCSPQ 416
              EN  R         ++EL     ++  + V HE   LK ++E+  +E  E R    P+
Sbjct: 1126 KHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPR 1185

Query: 417  DEDEERWQGREEESDEPTLENLPESQ 442
             +  E    R+ +  E   +   ES+
Sbjct: 1186 KKTLEEEFARKLQEQEVFFKMTGESE 1211


>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
          Length = 431

 Score =  139 bits (351), Expect = 6e-33
 Identities = 87/288 (30%), Positives = 145/288 (50%), Gaps = 16/288 (5%)

Query: 33  QKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIV 92
           +K+G GSFG V+   D + ++   +K++ ++   E   +E      E  +LS+ D P + 
Sbjct: 28  EKIGKGSFGEVFKGIDNRTQKVVAIKII-DLEEAE---DEIEDIQQEITVLSQCDSPYVT 83

Query: 93  KFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHER 152
           K++ S+++     II EY  G    D ++          E QI     ++L G+DY+H  
Sbjct: 84  KYYGSYLKDTKLWIIMEYLGGGSALDLLEPGP-----LDETQIATILREILKGLDYLHSE 138

Query: 153 RILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDT 211
           + +HRD+K+ NV L ++  +K+ DFGV+  L  +     T  GTP +M+PE +K   YD+
Sbjct: 139 KKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDS 198

Query: 212 KSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNKN 271
           K+DIWSL     E+       +  + + ++  I + + P+L   Y K L   +E+ LNK 
Sbjct: 199 KADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKE 258

Query: 272 PSLRPSAIEILKIPYL------DEQLQNLMCRYSEMTLEDKNLDCQKE 313
           PS RP+A E+LK  ++         L  L+ RY     E  + D   E
Sbjct: 259 PSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSE 306


>gi|93004081 polo-like kinase 2 [Homo sapiens]
          Length = 685

 Score =  137 bits (344), Expect = 4e-32
 Identities = 80/258 (31%), Positives = 135/258 (52%), Gaps = 8/258 (3%)

Query: 27  RRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL 86
           +RY   + LG G F   Y ++D    +    K++    V + +  E +   +E   +  L
Sbjct: 80  KRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRI--L 137

Query: 87  DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGV 146
            H  +V+F+  F +++N  I+ EYC  R +   ++    A K+  E ++  +  Q++ G+
Sbjct: 138 HHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILK----ARKVLTEPEVRYYLRQIVSGL 193

Query: 147 DYMHERRILHRDLKSKNVFLKNNL-LKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALK 205
            Y+HE+ ILHRDLK  N F+   + LK+GDFG++  L        T+ GTP+Y+SPE L 
Sbjct: 194 KYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLN 253

Query: 206 HQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIME 265
            QG+  +SDIW+L C++Y M      F  +N L    + +     ++P         ++ 
Sbjct: 254 KQGHGCESDIWALGCVMYTMLLGRPPFETTN-LKETYRCIREARYTMPSSLLAPAKHLIA 312

Query: 266 SMLNKNPSLRPSAIEILK 283
           SML+KNP  RPS  +I++
Sbjct: 313 SMLSKNPEDRPSLDDIIR 330


>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
          Length = 968

 Score =  134 bits (336), Expect = 3e-31
 Identities = 89/281 (31%), Positives = 146/281 (51%), Gaps = 18/281 (6%)

Query: 34  KLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVK 93
           +LG G+FG VY   +K+       KV++  S  EL         +E ++L+  DHP IVK
Sbjct: 41  ELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELE-----DYIVEIEILATCDHPYIVK 95

Query: 94  FHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERR 153
              ++       I+ E+C G  +D  + E  + G   P+ Q++    Q+L  ++++H +R
Sbjct: 96  LLGAYYHDGKLWIMIEFCPGGAVDAIMLELDR-GLTEPQIQVV--CRQMLEALNFLHSKR 152

Query: 154 ILHRDLKSKNVFLK-NNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEA-----LKHQ 207
           I+HRDLK+ NV +     +++ DFGVS   + +     +  GTP++M+PE      +K  
Sbjct: 153 IIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDT 212

Query: 208 GYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSL--PERYPKELNAIME 265
            YD K+DIWSL   L EM  +       N + ++LKI + D P+L  P ++  E    ++
Sbjct: 213 PYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLK 272

Query: 266 SMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDK 306
             L+KNP  RPSA ++L+ P++     N   R  E+  E K
Sbjct: 273 IALDKNPETRPSAAQLLEHPFVSSITSNKALR--ELVAEAK 311



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 38/168 (22%), Positives = 77/168 (45%), Gaps = 12/168 (7%)

Query: 238 LSIVLKIVEGDTPSLPERYPKE-LNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMC 296
           L ++ K V+ +   LP +  KE +   ME    K         ++L   ++ +Q ++L  
Sbjct: 657 LKLMKKEVKNEVEKLPRQQRKESMKQKMEEHTQKK--------QLLDRDFVAKQKEDLEL 708

Query: 297 RYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEK 356
               +T +++   C KE   ++   ++ +      AL E+++   +ER +L K Q  D+ 
Sbjct: 709 AMKRLTTDNRREICDKERECLMK--KQELLRDREAALWEMEEHQLQERHQLVKQQLKDQY 766

Query: 357 ARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKE 404
             +  +++  K+E+  ++MQ    R  +QL V    EK  L  ++  E
Sbjct: 767 FLQRHELLR-KHEKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSE 813



 Score = 33.5 bits (75), Expect = 0.62
 Identities = 35/166 (21%), Positives = 73/166 (43%), Gaps = 32/166 (19%)

Query: 289 EQLQNLMCRYSEMTLEDKNLDCQKEAAHI-----------INAMQKRIHLQTLRALSEVQ 337
           E+ +  M RY++  +E   +  Q+E A +           +   +K +H+    + +E  
Sbjct: 778 EKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAE-- 835

Query: 338 KMTPRERMRLRKLQAADEKARKLKKIVEEKYEENSKR---------MQELRSRNFQQLSV 388
                +R ++++    +EK +K +++ +++  EN  R         M EL+    ++  +
Sbjct: 836 -----QREKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHL 890

Query: 389 DVLHEKTHLKGMEEKEEQ--PEGRLSCSPQD---EDEERWQGREEE 429
            V HE   LK ++E   Q   E R    P+    E++   + RE+E
Sbjct: 891 LVEHETQKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQE 936


>gi|21359873 polo-like kinase 1 [Homo sapiens]
          Length = 603

 Score =  132 bits (333), Expect = 8e-31
 Identities = 79/257 (30%), Positives = 134/257 (52%), Gaps = 8/257 (3%)

Query: 27  RRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL 86
           RRYV  + LG G F   + +SD   K     K++ +  +  L P++  + ++E  +   L
Sbjct: 51  RRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLL--LKPHQREKMSMEISIHRSL 108

Query: 87  DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGV 146
            H  +V FH  F + D   ++ E C  R L     E  +  K   E +   +  Q++LG 
Sbjct: 109 AHQHVVGFHGFFEDNDFVFVVLELCRRRSL----LELHKRRKALTEPEARYYLRQIVLGC 164

Query: 147 DYMHERRILHRDLKSKNVFLKNNL-LKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALK 205
            Y+H  R++HRDLK  N+FL  +L +KIGDFG++  +    +   TL GTP+Y++PE L 
Sbjct: 165 QYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLS 224

Query: 206 HQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIME 265
            +G+  + D+WS+ CI+Y +      F  S      L+I + +  S+P+       ++++
Sbjct: 225 KKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEY-SIPKHINPVAASLIQ 283

Query: 266 SMLNKNPSLRPSAIEIL 282
            ML  +P+ RP+  E+L
Sbjct: 284 KMLQTDPTARPTINELL 300


>gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]
          Length = 586

 Score =  130 bits (326), Expect = 5e-30
 Identities = 99/307 (32%), Positives = 161/307 (52%), Gaps = 32/307 (10%)

Query: 18  STYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVL--KEISVG---ELNPNE 72
           S YPK L    Y++ + LGSG+ G V L  ++K  +   +K++  ++ ++G   E +P  
Sbjct: 253 SVYPKAL-RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPAL 311

Query: 73  TVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPE 132
            V+  +E  +L KL+HP I+K   +F + +++ I+ E  EG +L DK+   K+      E
Sbjct: 312 NVETEIE--ILKKLNHPCIIKIK-NFFDAEDYYIVLELMEGGELFDKVVGNKR----LKE 364

Query: 133 NQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNN----LLKIGDFGVSRLLMGSCDL 188
                +F Q+LL V Y+HE  I+HRDLK +NV L +     L+KI DFG S++L G   L
Sbjct: 365 ATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKIL-GETSL 423

Query: 189 ATTLTGTPHYMSPEALKH---QGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLK-- 243
             TL GTP Y++PE L      GY+   D WSL  IL+ +C   +     +   + LK  
Sbjct: 424 MRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILF-ICLSGYPPFSEHRTQVSLKDQ 482

Query: 244 IVEGDTPSLPE---RYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQ-----LQNLM 295
           I  G    +PE      ++   +++ +L  +P  R +  E L+ P+L ++      Q+L+
Sbjct: 483 ITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLL 542

Query: 296 CRYSEMT 302
              +E T
Sbjct: 543 SEENEST 549


>gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]
          Length = 543

 Score =  130 bits (326), Expect = 5e-30
 Identities = 99/307 (32%), Positives = 161/307 (52%), Gaps = 32/307 (10%)

Query: 18  STYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVL--KEISVG---ELNPNE 72
           S YPK L    Y++ + LGSG+ G V L  ++K  +   +K++  ++ ++G   E +P  
Sbjct: 210 SVYPKAL-RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPAL 268

Query: 73  TVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPE 132
            V+  +E  +L KL+HP I+K   +F + +++ I+ E  EG +L DK+   K+      E
Sbjct: 269 NVETEIE--ILKKLNHPCIIKIK-NFFDAEDYYIVLELMEGGELFDKVVGNKR----LKE 321

Query: 133 NQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNN----LLKIGDFGVSRLLMGSCDL 188
                +F Q+LL V Y+HE  I+HRDLK +NV L +     L+KI DFG S++L G   L
Sbjct: 322 ATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKIL-GETSL 380

Query: 189 ATTLTGTPHYMSPEALKH---QGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLK-- 243
             TL GTP Y++PE L      GY+   D WSL  IL+ +C   +     +   + LK  
Sbjct: 381 MRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILF-ICLSGYPPFSEHRTQVSLKDQ 439

Query: 244 IVEGDTPSLPE---RYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQ-----LQNLM 295
           I  G    +PE      ++   +++ +L  +P  R +  E L+ P+L ++      Q+L+
Sbjct: 440 ITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLL 499

Query: 296 CRYSEMT 302
              +E T
Sbjct: 500 SEENEST 506


>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
          Length = 1315

 Score =  129 bits (325), Expect = 6e-30
 Identities = 84/267 (31%), Positives = 142/267 (53%), Gaps = 22/267 (8%)

Query: 28  RYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANL--EAQLLSK 85
           +Y + + +G GSFG VY     K +R    +V+    + +L  +E    NL  E +++  
Sbjct: 3   KYHVLEMIGEGSFGRVY-----KGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRG 57

Query: 86  LDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLG 145
           L HP IV    SF       ++T+Y EG    +  Q  +  GK+ PE+Q+     QL+  
Sbjct: 58  LRHPNIVHMLDSFETDKEVVVVTDYAEG----ELFQILEDDGKL-PEDQVQAIAAQLVSA 112

Query: 146 VDYMHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEAL 204
           + Y+H  RILHRD+K +N+ L K   +K+ DFG +R +  +  + T++ GTP YMSPE +
Sbjct: 113 LYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELV 172

Query: 205 KHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNA-- 262
           + + YD  +D+WS+ CILYE+      F  ++   +V  I++      P R+P  ++   
Sbjct: 173 EERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKD-----PVRWPSTISPCF 227

Query: 263 --IMESMLNKNPSLRPSAIEILKIPYL 287
              ++ +L K+P  R S  ++L  P++
Sbjct: 228 KNFLQGLLTKDPRQRLSWPDLLYHPFI 254


>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
           sapiens]
          Length = 416

 Score =  127 bits (319), Expect = 3e-29
 Identities = 77/256 (30%), Positives = 137/256 (53%), Gaps = 10/256 (3%)

Query: 33  QKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIV 92
           +++G GSFG V+   D + ++   +K++ ++   E   +E      E  +LS+ D   + 
Sbjct: 28  ERIGKGSFGEVFKGIDNRTQQVVAIKII-DLEEAE---DEIEDIQQEITVLSQCDSSYVT 83

Query: 93  KFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHER 152
           K++ S+++     II EY  G    D ++    AG  F E QI     ++L G+DY+H  
Sbjct: 84  KYYGSYLKGSKLWIIMEYLGGGSALDLLR----AGP-FDEFQIATMLKEILKGLDYLHSE 138

Query: 153 RILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDT 211
           + +HRD+K+ NV L +   +K+ DFGV+  L  +     T  GTP +M+PE ++   YD+
Sbjct: 139 KKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDS 198

Query: 212 KSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNKN 271
           K+DIWSL     E+       +  + + ++  I + + P+L   + K     +++ LNK+
Sbjct: 199 KADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKD 258

Query: 272 PSLRPSAIEILKIPYL 287
           PS RP+A E+LK  ++
Sbjct: 259 PSFRPTAKELLKHKFI 274


>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
          Length = 426

 Score =  127 bits (319), Expect = 3e-29
 Identities = 89/296 (30%), Positives = 142/296 (47%), Gaps = 25/296 (8%)

Query: 34  KLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVK 93
           ++G GSFG VY   D   K   E+  +K I + E   +E      E  +LS+ D P I +
Sbjct: 25  RIGKGSFGEVYKGIDNHTK---EVVAIKIIDLEEAE-DEIEDIQQEITVLSQCDSPYITR 80

Query: 94  FHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERR 153
           +  S+++     II EY  G    D ++          E  I     ++L G+DY+H  R
Sbjct: 81  YFGSYLKSTKLWIIMEYLGGGSALDLLKPGP-----LEETYIATILREILKGLDYLHSER 135

Query: 154 ILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTK 212
            +HRD+K+ NV L +   +K+ DFGV+  L  +     T  GTP +M+PE +K   YD K
Sbjct: 136 KIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFK 195

Query: 213 SDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNKNP 272
           +DIWSL     E+       +  + + ++  I +   P+L  ++ K     +E+ LNK+P
Sbjct: 196 ADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDP 255

Query: 273 SLRPSAIEILKIPYLDEQ------LQNLMCRY---------SEMTLEDKNLDCQKE 313
             RP+A E+LK  ++         L  L+ RY          E + ED ++D + E
Sbjct: 256 RFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHGEESSSEDSDIDGEAE 311


>gi|41872374 polo-like kinase 3 [Homo sapiens]
          Length = 646

 Score =  127 bits (318), Expect = 4e-29
 Identities = 79/258 (30%), Positives = 131/258 (50%), Gaps = 8/258 (3%)

Query: 27  RRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL 86
           R Y+  + LG G F   Y  +D +      +KV+ +  V + +  E +   +E  L   L
Sbjct: 60  RTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIE--LHRDL 117

Query: 87  DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGV 146
            H  IV+F   F + DN  I  E C  + L        +A     E ++  +  Q+L G+
Sbjct: 118 QHRHIVRFSHHFEDADNIYIFLELCSRKSL----AHIWKARHTLLEPEVRYYLRQILSGL 173

Query: 147 DYMHERRILHRDLKSKNVFLKNNL-LKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALK 205
            Y+H+R ILHRDLK  N F+  N+ LK+GDFG++  L        T+ GTP+Y++PE L 
Sbjct: 174 KYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL 233

Query: 206 HQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIME 265
            QG+  ++D+WSL C++Y + C +  F  ++ L    + ++    +LP         ++ 
Sbjct: 234 RQGHGPEADVWSLGCVMYTLLCGSPPFETAD-LKETYRCIKQVHYTLPASLSLPARQLLA 292

Query: 266 SMLNKNPSLRPSAIEILK 283
           ++L  +P  RPS  +IL+
Sbjct: 293 AILRASPRDRPSIDQILR 310


>gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Homo
           sapiens]
          Length = 619

 Score =  123 bits (309), Expect = 5e-28
 Identities = 87/263 (33%), Positives = 132/263 (50%), Gaps = 18/263 (6%)

Query: 31  LQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANL---EAQLLSKLD 87
           L + LG G+FG VYL  D     G EL V K++     +P  + + N    E QLL  L 
Sbjct: 358 LGKLLGQGAFGRVYLCYD--VDTGRELAV-KQVQFDPDSPETSKEVNALECEIQLLKNLL 414

Query: 88  HPAIVKFHASF--VEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLG 145
           H  IV+++      ++    I  EY  G  + D+++ Y        EN   ++  Q+L G
Sbjct: 415 HERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGA----LTENVTRKYTRQILEG 470

Query: 146 VDYMHERRILHRDLKSKNVFLKNN-LLKIGDFGVSRLLMGSCDLAT---TLTGTPHYMSP 201
           V Y+H   I+HRD+K  N+   +   +K+GDFG S+ L   C   T   ++TGTP++MSP
Sbjct: 471 VHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSP 530

Query: 202 EALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDT-PSLPERYPKEL 260
           E +  +GY  K+DIWS+AC + EM      +A    ++ + KI    T P LP       
Sbjct: 531 EVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYT 590

Query: 261 NAIMESMLNKNPSLRPSAIEILK 283
              ++ +      LRPSA E+L+
Sbjct: 591 RDFLKRIF-VEAKLRPSADELLR 612


>gi|150456432 unc-51-like kinase 3 [Homo sapiens]
          Length = 472

 Score =  123 bits (308), Expect = 6e-28
 Identities = 82/265 (30%), Positives = 131/265 (49%), Gaps = 12/265 (4%)

Query: 29  YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDH 88
           ++L ++LGSG++ TVY    KK  R  E+  +K ++   LN         E ++L  + H
Sbjct: 14  FILTERLGSGTYATVYKAYAKKDTR--EVVAIKCVAKKSLNKASVENLLTEIEILKGIRH 71

Query: 89  PAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDY 148
           P IV+      + DN  +I E+C G DL      +    +I PE     +  QL   + +
Sbjct: 72  PHIVQLKDFQWDSDNIYLIMEFCAGGDLS----RFIHTRRILPEKVARVFMQQLASALQF 127

Query: 149 MHERRILHRDLKSKNVFLKN---NLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALK 205
           +HER I H DLK +N+ L +     LK+ DFG ++  M   D    L G+P YM+PE + 
Sbjct: 128 LHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQH-MSPWDEKHVLRGSPLYMAPEMVC 186

Query: 206 HQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPER--YPKELNAI 263
            + YD + D+WS+  ILYE       FA  +F  +  KI       LP R    ++   +
Sbjct: 187 QRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDL 246

Query: 264 MESMLNKNPSLRPSAIEILKIPYLD 288
           ++ +L ++PS R S  +    P++D
Sbjct: 247 LQRLLERDPSRRISFQDFFAHPWVD 271


>gi|153945765 mitogen-activated protein kinase kinase kinase 1 [Homo
            sapiens]
          Length = 1512

 Score =  120 bits (302), Expect = 3e-27
 Identities = 79/264 (29%), Positives = 130/264 (49%), Gaps = 15/264 (5%)

Query: 33   QKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQA-NLEAQLLSKLDHPAI 91
            Q++G G+F + Y   D        +K +  +        E V+A   E +++S L+HP I
Sbjct: 1247 QQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNI 1306

Query: 92   VKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHE 151
            ++   +  E+ N+ +  E+  G  +   + +Y      F E+ +I +  QLL G+ Y+HE
Sbjct: 1307 IRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGA----FKESVVINYTEQLLRGLSYLHE 1362

Query: 152  RRILHRDLKSKNVFLKNN--LLKIGDFGVSRLLM----GSCDLATTLTGTPHYMSPEALK 205
             +I+HRD+K  N+ + +    L+I DFG +  L     G+ +    L GT  +M+PE L+
Sbjct: 1363 NQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLR 1422

Query: 206  HQGYDTKSDIWSLACILYEMCCMN---HAFAGSNFLSIVLKIVEGDT-PSLPERYPKELN 261
             Q Y    D+WS+ C + EM C     +A   SN L+++ KI    T PS+P      L 
Sbjct: 1423 GQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLR 1482

Query: 262  AIMESMLNKNPSLRPSAIEILKIP 285
             +    L   P  RP + E+LK P
Sbjct: 1483 DVALRCLELQPQDRPPSRELLKHP 1506


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.131    0.372 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,769,252
Number of Sequences: 37866
Number of extensions: 1192856
Number of successful extensions: 10747
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 724
Number of HSP's successfully gapped in prelim test: 697
Number of HSP's that attempted gapping in prelim test: 5786
Number of HSP's gapped (non-prelim): 2953
length of query: 645
length of database: 18,247,518
effective HSP length: 109
effective length of query: 536
effective length of database: 14,120,124
effective search space: 7568386464
effective search space used: 7568386464
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.