Search of human proteins with 223890252

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|223890252 glutamate receptor interacting protein 1 [Homo
sapiens]
         (1076 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|223890252 glutamate receptor interacting protein 1 [Homo sapi...  2107   0.0  
gi|122937249 glutamate receptor interacting protein 2 [Homo sapi...  1138   0.0  
gi|148746189 multiple PDZ domain protein [Homo sapiens]               123   8e-28
gi|112382257 InaD-like [Homo sapiens]                                 112   2e-24
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]                     107   6e-23
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi...    97   8e-20
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]           94   5e-19
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]           94   5e-19
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa...    93   2e-18
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi...    92   2e-18
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom...    87   8e-17
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom...    87   1e-16
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom...    86   1e-16
gi|45827729 scribble isoform b [Homo sapiens]                          86   2e-16
gi|45827731 scribble isoform a [Homo sapiens]                          86   2e-16
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]                      84   9e-16
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]                       84   9e-16
gi|218505835 membrane-associated guanylate kinase-related  3 iso...    82   2e-15
gi|148833504 interleukin 16 isoform 2 [Homo sapiens]                   75   3e-13
gi|27262655 interleukin 16 isoform 1 precursor [Homo sapiens]          75   3e-13
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i...    75   4e-13
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i...    75   4e-13
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is...    75   4e-13
gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]       74   6e-13
gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens]       74   6e-13
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa...    74   6e-13
gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sa...    74   6e-13
gi|155969695 membrane-associated guanylate kinase-related  3 iso...    74   7e-13
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i...    72   3e-12
gi|24025688 ligand of numb-protein X 2 [Homo sapiens]                  69   3e-11

>gi|223890252 glutamate receptor interacting protein 1 [Homo sapiens]
          Length = 1076

 Score = 2107 bits (5458), Expect = 0.0
 Identities = 1076/1076 (100%), Positives = 1076/1076 (100%)

Query: 1    MIAVSFKCRCQILRRLTKDESPYTKSASQTKPPDGALAVRRQSIPEEFKGSTVVELMKKE 60
            MIAVSFKCRCQILRRLTKDESPYTKSASQTKPPDGALAVRRQSIPEEFKGSTVVELMKKE
Sbjct: 1    MIAVSFKCRCQILRRLTKDESPYTKSASQTKPPDGALAVRRQSIPEEFKGSTVVELMKKE 60

Query: 61   GTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISL 120
            GTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISL
Sbjct: 61   GTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISL 120

Query: 121  LKNVGERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPV 180
            LKNVGERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPV
Sbjct: 121  LKNVGERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPV 180

Query: 181  VITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSV 240
            VITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSV
Sbjct: 181  VITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSV 240

Query: 241  MDSVATASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDH 300
            MDSVATASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDH
Sbjct: 241  MDSVATASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDH 300

Query: 301  ILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHAALVSSSFSPTSM 360
            ILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHAALVSSSFSPTSM
Sbjct: 301  ILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHAALVSSSFSPTSM 360

Query: 361  SAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQVVHTETTE 420
            SAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQVVHTETTE
Sbjct: 361  SAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQVVHTETTE 420

Query: 421  VVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPT 480
            VVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPT
Sbjct: 421  VVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPT 480

Query: 481  EDSTFEEASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITISSPS 540
            EDSTFEEASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITISSPS
Sbjct: 481  EDSTFEEASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITISSPS 540

Query: 541  SRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKL 600
            SRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKL
Sbjct: 541  SRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKL 600

Query: 601  KIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTG 660
            KIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTG
Sbjct: 601  KIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTG 660

Query: 661  AIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQSASSPKKFPISSHL 720
            AIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQSASSPKKFPISSHL
Sbjct: 661  AIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQSASSPKKFPISSHL 720

Query: 721  SDLGDVEEDSSPAQKPGKLSDMYPSTVPSVDSAVDSWDGSAIDTSYGTQGTSFQASGYNF 780
            SDLGDVEEDSSPAQKPGKLSDMYPSTVPSVDSAVDSWDGSAIDTSYGTQGTSFQASGYNF
Sbjct: 721  SDLGDVEEDSSPAQKPGKLSDMYPSTVPSVDSAVDSWDGSAIDTSYGTQGTSFQASGYNF 780

Query: 781  NTYDWRSPKQRGSLSPVTKPRSQTYPDVGLSYEDWDRSTASGFAGAADSAETEQEENFWS 840
            NTYDWRSPKQRGSLSPVTKPRSQTYPDVGLSYEDWDRSTASGFAGAADSAETEQEENFWS
Sbjct: 781  NTYDWRSPKQRGSLSPVTKPRSQTYPDVGLSYEDWDRSTASGFAGAADSAETEQEENFWS 840

Query: 841  QALEDLETCGQSGILRELEEKADRRVSLRNMTLLATIMSGSTMSLNHEAPTPRSQLGRQA 900
            QALEDLETCGQSGILRELEEKADRRVSLRNMTLLATIMSGSTMSLNHEAPTPRSQLGRQA
Sbjct: 841  QALEDLETCGQSGILRELEEKADRRVSLRNMTLLATIMSGSTMSLNHEAPTPRSQLGRQA 900

Query: 901  SFQERSSSRPHYSQTTRSNTLPSDVGRKSVTLRKMKQEIKEIMSPTPVELHKVTLYKDSD 960
            SFQERSSSRPHYSQTTRSNTLPSDVGRKSVTLRKMKQEIKEIMSPTPVELHKVTLYKDSD
Sbjct: 901  SFQERSSSRPHYSQTTRSNTLPSDVGRKSVTLRKMKQEIKEIMSPTPVELHKVTLYKDSD 960

Query: 961  MEDFGFSVADGLLEKGVYVKNIRPAGPGDLGGLKPYDRLLQVNHVRTRDFDCCLVVPLIA 1020
            MEDFGFSVADGLLEKGVYVKNIRPAGPGDLGGLKPYDRLLQVNHVRTRDFDCCLVVPLIA
Sbjct: 961  MEDFGFSVADGLLEKGVYVKNIRPAGPGDLGGLKPYDRLLQVNHVRTRDFDCCLVVPLIA 1020

Query: 1021 ESGNKLDLVISRNPLASQKSIDQQSLPGDWSEQNSAFFQQPSHGGNLETREPTNTL 1076
            ESGNKLDLVISRNPLASQKSIDQQSLPGDWSEQNSAFFQQPSHGGNLETREPTNTL
Sbjct: 1021 ESGNKLDLVISRNPLASQKSIDQQSLPGDWSEQNSAFFQQPSHGGNLETREPTNTL 1076


>gi|122937249 glutamate receptor interacting protein 2 [Homo sapiens]
          Length = 1141

 Score = 1138 bits (2943), Expect = 0.0
 Identities = 623/1077 (57%), Positives = 766/1077 (71%), Gaps = 115/1077 (10%)

Query: 19   DESPYTKSASQTKPPDGALAVRRQSIPEEFKGSTVVELMKKEGTTLGLTVSGGIDKDGKP 78
            D+ PY+K        D +LA RRQSIPEEF+G TVVEL+KKEG+TLGLT+SGG DKDGKP
Sbjct: 111  DDGPYSKGGKDAGGADVSLACRRQSIPEEFRGITVVELIKKEGSTLGLTISGGTDKDGKP 170

Query: 79   RVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEYELPP 138
            RVSNLR GG+AARSD L++GDYI++VNGI+L + RHDEII+LLKNVGERVVLEVEYELPP
Sbjct: 171  RVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPP 230

Query: 139  VSVQGSS-VIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTI 197
             + + +  +I +TV+V+L+KEGN+FGFV+RGGAH+D +KSRP+V+T VRPGGPADREG++
Sbjct: 231  PAPENNPRIISKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSL 290

Query: 198  KPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASGPLLVEVAK 257
            K GDRLLSVDGI L G +HA A++ L+QC  EA   +EYDV+  D+VA ASGPL+VE+ K
Sbjct: 291  KVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYDVATPDTVANASGPLMVEIVK 350

Query: 258  TPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEA 317
            TPG++LG++LTT+   NK VI ID+IK AS+ DR GALH GDHILSIDGTSME+C+L EA
Sbjct: 351  TPGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEA 410

Query: 318  TQFLANTTDQVKLEILPHHQTRLALK---------------------------------- 343
            T+ LA+ +++V+LEILP  Q++  L+                                  
Sbjct: 411  TKLLASISEKVRLEILPVPQSQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPRPGHCRM 470

Query: 344  -------GPDHAALVSSS--FSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKK 394
                   G D +  +SS+   SPT   A+S +  N  TLPR     SPR TM RRR +++
Sbjct: 471  PTWATPAGQDQSRSLSSTPFSSPTLNHAFSCN--NPSTLPRGSQPMSPRTTMGRRRQRRR 528

Query: 395  DFKSSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYI 454
            + KSSLSLASSTVG  GQ+VHTETTEVVL  DP++GFG+QLQG +FATETLSSPPL+ +I
Sbjct: 529  EHKSSLSLASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFI 588

Query: 455  EADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVAESVI 514
            E DSPAERCG+LQ+GDRV++INGI TED T EEA+QLLRD+++  KV LE+EFDVAESVI
Sbjct: 589  EPDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLEVEFDVAESVI 648

Query: 515  PSSGTFHVKLPKKHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAI 574
            PSSGTFHVKLPKK +VELGITISS +SRK G+PL+ISDIKKGSVAHRTGTLE GDKLLAI
Sbjct: 649  PSSGTFHVKLPKKRSVELGITISS-ASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAI 707

Query: 575  DNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGPLGIT 634
            DNIRLDNC MEDAVQIL+QCEDLVKLKIRKDEDNSDE E++GA+ YTVELKRYGGPLGIT
Sbjct: 708  DNIRLDNCPMEDAVQILRQCEDLVKLKIRKDEDNSDELETTGAVSYTVELKRYGGPLGIT 767

Query: 635  ISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGET 694
            ISGTEEPFDPI+IS LTK GLAERTGAIH+GDRILAIN+ SLKG+PLSEAIHLLQ+AGET
Sbjct: 768  ISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGET 827

Query: 695  VTLKIKKQTDAQSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDMYPSTVPSVDSAV 754
            VTLKIKKQ D      P+K   S  LS+  D +ED + A K G  +  +   VPSVDSAV
Sbjct: 828  VTLKIKKQLDRPLL--PRK---SGSLSETSDADEDPADALKGGLPAARFSPAVPSVDSAV 882

Query: 755  DSWDGSAIDTSYGTQGTSFQASGYNFNTYDWRSPKQRGSLSPVTKPRSQTYPDVGLSY-- 812
            +SWD SA +  +G  G+    +     T   R P       P T+PR  +Y         
Sbjct: 883  ESWDSSATEGGFGGPGSYTPQAAARGTTPQERRPGWLRGSPPPTEPRRTSYTPTPADESF 942

Query: 813  ------EDWDRSTASGFAGAADSAETEQEENFW---SQALEDLETCGQSGILRELEEKAD 863
                  +DW+  T+     A       +EE FW    +ALEDLE+CGQS +LRELE    
Sbjct: 943  PEEEEEDDWEPPTSPAPGPA-------REEGFWRMFGEALEDLESCGQSELLRELE---- 991

Query: 864  RRVSLRNMTLLATIMSGSTMSLNHEAPTPRSQLGRQASFQERSSSRPHYSQTTRSNTLPS 923
                       A+IM+G+                ++ + + R   RP             
Sbjct: 992  -----------ASIMTGTV---------------QRVALEGRPGHRPWQR---------- 1015

Query: 924  DVGRKSVTLRKMKQEIKEIMSPTPVELHKVTLYKDSDMEDFGFSVADGLLEKGVYVKNIR 983
              GR+   +R    E++E++ PTP+E+HKVTL+KD    DFGFSV+DGLLEKGVYV  +R
Sbjct: 1016 --GRE---VRASPAEMEELLLPTPLEMHKVTLHKDPMRHDFGFSVSDGLLEKGVYVHTVR 1070

Query: 984  PAGPGDLGGLKPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISRNPLASQKS 1040
            P GP   GGL+P+DR+LQVNHVRTRDFDCCL VPL+AE+G+ L+L+ISR P  +  S
Sbjct: 1071 PDGPAHRGGLQPFDRVLQVNHVRTRDFDCCLAVPLLAEAGDVLELIISRKPHTAHSS 1127


>gi|148746189 multiple PDZ domain protein [Homo sapiens]
          Length = 2041

 Score =  123 bits (309), Expect = 8e-28
 Identities = 145/627 (23%), Positives = 270/627 (43%), Gaps = 92/627 (14%)

Query: 153  VTLHKEGNTFGFVIRGGAHDDRNKSR-PVVITCVRPGGPADREGTIKPGDRLLSVDGIRL 211
            + L K  +  G  + G    ++++SR  V I  + P G A ++G ++  D LL ++G  L
Sbjct: 1351 IELEKGHSGLGLSLAG----NKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQIL 1406

Query: 212  LGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASGPLL------------------- 252
             G +H  A SI+K    +  ++   +   ++ +A   G  +                   
Sbjct: 1407 YGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTV 1466

Query: 253  -----------------VEVAKTPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGAL 295
                             +E+ K  G  LG+A++     +   ++I  +    +A   G L
Sbjct: 1467 TTSDAAVDLSSFKNVQHLELPKDQGG-LGIAISEEDTLSG--VIIKSLTEHGVAATDGRL 1523

Query: 296  HVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHAALVSSSF 355
             VGD IL++D   +    + +    L      VKL I          + PD  A+ S++ 
Sbjct: 1524 KVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI--------HAENPDSQAVPSAAG 1575

Query: 356  SPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQVVH 415
            + +     S  SL    +P+S       G+     ++     S+ ++ +S       +  
Sbjct: 1576 AASGEKKNSSQSL---MVPQS-------GSPEPESIRNTSRSSTPAIFASDPATCPIIPG 1625

Query: 416  TETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAI 475
             ETT  +  +   TG G+ + G    ++TL    +I  +  +  A + G L  GD+++ +
Sbjct: 1626 CETT--IEISKGRTGLGLSIVGG---SDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEV 1680

Query: 476  NGIPTEDSTFEEASQLLRDSSITSKVTL-EIEFDVAESVIPSSGTFHVKLPKKHNVELGI 534
            NGI    +T +EA  +LR +    ++TL   E    E  +    T  ++L KK    LG+
Sbjct: 1681 NGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEV--CDTLTIELQKKPGKGLGL 1738

Query: 535  TISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQC 594
            +I     ++    + +SDI KG +A   G L  GD++L ++   + N + E    +L+  
Sbjct: 1739 SIVG---KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVS 1795

Query: 595  EDLVK-----LKIRKDEDNSDEQESSGAI------IYTVELKRYGGP---LGITISG-TE 639
            E  +      L      ++ +      A+      + TVE+K+  GP   LGI+I+G   
Sbjct: 1796 EGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKK--GPTDSLGISIAGGVG 1853

Query: 640  EPFD--PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTL 697
             P    PI I+ +   G+A +T  + +GDRI+ I  +S +G   ++A++LL+ A  ++ +
Sbjct: 1854 SPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEM 1913

Query: 698  KIKKQTDAQSASSPKKFPISSHLSDLG 724
            ++    D    +  ++ P SS LS  G
Sbjct: 1914 QVVAGGDVSVVTGHQQEPASSSLSFTG 1940



 Score =  117 bits (292), Expect = 8e-26
 Identities = 157/718 (21%), Positives = 284/718 (39%), Gaps = 138/718 (19%)

Query: 53  VVELMKKEGTTLGLTVSGGIDKDGKPR----VSNLRQGGIAARSDQLDVGDYIKAVNGIN 108
           V EL+K     LG +V G +  + +      V  +++G +A R  +L   D I A+NG  
Sbjct: 137 VFELLKPPSGGLGFSVVG-LRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQA 195

Query: 109 LAK-FRHDEIISLLKNVGERVVLEVEYELPP----------------VSVQGSSVIFRTV 151
           L +   H + IS+L+   + V L +     P                +S   + V ++ +
Sbjct: 196 LDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHM 255

Query: 152 E-VTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIR 210
           E + L  +G+  GF I GG      K+  V++  + PGG AD+ G +  GD +L +    
Sbjct: 256 ETIELVNDGSGLGFGIIGG------KATGVIVKTILPGGVADQHGRLCSGDHILKIGDTD 309

Query: 211 LLGTTHAEAMSILKQCGQEAALLIEYDVS-----------VMDSVATASGPLLVEVAKTP 259
           L G +  +   +L+QCG    L+I                 + S  T++  L V+ +   
Sbjct: 310 LAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQK 369

Query: 260 GAS--------------LGVALTTSMCCNK---QVIVIDKIKSASIADRCGALHVGDHIL 302
           G                LG+ +   +   K     I +  I  +S  +  G + +GD I+
Sbjct: 370 GEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQII 429

Query: 303 SIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQ------------TRLALKGPDHAAL 350
           ++DGT+++  T  +A + L +T   V L ++                T+ A   P +A++
Sbjct: 430 AVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASI 489

Query: 351 VSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLA 410
           +  ++        S  + N+       Y             +K++  + L+     +G+ 
Sbjct: 490 IKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQE-AALLTKWQRIMGIN 548

Query: 411 GQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGD 470
            ++V    ++        +G GI L+ +V           I  +  + P    G L  GD
Sbjct: 549 YEIVVAHVSKF----SENSGLGISLEATV-------GHHFIRSVLPEGPVGHSGKLFSGD 597

Query: 471 RVMAINGIPTEDSTFEEASQLLRDSSI--TSKVTLEIEFDVAESVIPSSGTFHVKLPKKH 528
            ++ +NGI       ++   +L++  I  T            +S + S     ++L +K 
Sbjct: 598 ELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKP 657

Query: 529 NVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAV 588
           +V+LG  I                          G+ E  D +LA          M DA 
Sbjct: 658 HVDLGEFI--------------------------GSSETEDPVLA----------MTDAG 681

Query: 589 QILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEPFDP---- 644
           Q  ++ +  + +                A I  +EL++    LG +I   ++P DP    
Sbjct: 682 QSTEEVQAPLAMW--------------EAGIQHIELEKGSKGLGFSILDYQDPIDPASTV 727

Query: 645 IIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMA-GETVTLKIKK 701
           III SL  GG+AE+ G +  GDR++ +N  +L+   L EA+  L+ A   TV + + K
Sbjct: 728 IIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAK 785



 Score =  103 bits (257), Expect = 9e-22
 Identities = 151/631 (23%), Positives = 245/631 (38%), Gaps = 145/631 (22%)

Query: 48   FKGSTVVELMKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGI 107
            FK    +EL K +G  LG+ +S      G   + +L + G+AA   +L VGD I AV+  
Sbjct: 1478 FKNVQHLELPKDQGG-LGIAISEEDTLSGVI-IKSLTEHGVAATDGRLKVGDQILAVDDE 1535

Query: 108  NLAKFRHDEIISLLKNVGERVVLEVEYELP------------------------------ 137
             +  +  ++ ISLLK     V L +  E P                              
Sbjct: 1536 IVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGS 1595

Query: 138  --PVSVQGSS-----VIF--------------RTVEVTLHKEGNTFGFVIRGGAHDDRNK 176
              P S++ +S      IF               T+E++  + G   G  I GG+      
Sbjct: 1596 PEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTG--LGLSIVGGSD---TL 1650

Query: 177  SRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEY 236
               ++I  V   G A ++G +  GD++L V+GI L   TH EA+++L+Q  Q   L +  
Sbjct: 1651 LGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYR 1710

Query: 237  DVSVMDSVATASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALH 296
            D +           L +E+ K PG  LG+++      N   + +  I    IAD  G L 
Sbjct: 1711 DEAPYKEEEVCD-TLTIELQKKPGKGLGLSIVGKR--NDTGVFVSDIVKGGIADADGRLM 1767

Query: 297  VGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHAALVSSSFS 356
             GD IL ++G  +             N T +    +L                       
Sbjct: 1768 QGDQILMVNGEDVR------------NATQEAVAALL----------------------- 1792

Query: 357  PTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQVVHT 416
               +S  SLSS    T P S  STS                 SL  +S    LA ++   
Sbjct: 1793 --KVSEGSLSSF---TFPLSGSSTS----------------ESLESSSKKNALASEIQGL 1831

Query: 417  ETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAIN 476
             T E  +   P    GI + G V  +     P  I+ +     A +   L++GDR++ I 
Sbjct: 1832 RTVE--MKKGPTDSLGISIAGGV-GSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTIC 1888

Query: 477  GIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVAE---------------SVIPSSGTFH 521
            G  TE  T  +A  LL+++S + ++ +    DV+                + + SS  F 
Sbjct: 1889 GTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQ 1948

Query: 522  VKL--PKKHNVE-------LGITISSPSSRKPGD-PLVISDIKKGSVAHRTGTLELGDKL 571
              L  P+  ++        LG +I        GD P+ +  +     A   G L+ GD++
Sbjct: 1949 DDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQI 2008

Query: 572  LAIDNIRLDNCSMEDAVQILQQCEDLVKLKI 602
            +A++   L+  + E+AV IL++ +  V L +
Sbjct: 2009 IAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 150/758 (19%), Positives = 290/758 (38%), Gaps = 138/758 (18%)

Query: 54   VELMKKEGTTLGLTVSGGIDKDGKPRVSNLRQG---------GIAARSDQLDVGDYIKAV 104
            VEL ++   +LG+++ GG     +     + +G           A ++  L  GD I  V
Sbjct: 1152 VELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEV 1211

Query: 105  NGINLAKFRHDEIISLLKNVGERVVLEVEYEL-PPVSVQGSSVIFRTVEVTLHKEGNTF- 162
            +G++L    H++ +  ++  G  VV  V+  +  P      S++            N F 
Sbjct: 1212 DGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFA 1271

Query: 163  -GFVIRGGAHDDRNKSRP--VVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEA 219
                I       +++S P    +  V P  P+                    +G+ H + 
Sbjct: 1272 DSLQINADKAPSQSESEPEKAPLCSVPPPPPS----------------AFAEMGSDHTQ- 1314

Query: 220  MSILKQCGQEAALLIEYDVS---VMDSVATASGPLLVEVAKTPGASLGVALTTSMCCNKQ 276
             S   +  Q+     E+  S   + +   T +G L +   +   + LG++L  +   ++ 
Sbjct: 1315 -SSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRM 1373

Query: 277  VIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHH 336
             + I  I     A + G L + D +L I+G  +   +   A+  +     +VK+  +   
Sbjct: 1374 SVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFI--- 1430

Query: 337  QTRLALKGPDHAALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDF 396
                                  +  A +  ++  G     L S S         L+ K+ 
Sbjct: 1431 ---------------------RNKDAVNQMAVCPGNAVEPLPSNS-------ENLQNKET 1462

Query: 397  KSSLSLASSTVGLAG--QVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYI 454
            + +++ + + V L+    V H E  +         G GI +     + E   S  +I  +
Sbjct: 1463 EPTVTTSDAAVDLSSFKNVQHLELPK------DQGGLGIAI-----SEEDTLSGVIIKSL 1511

Query: 455  EADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVAESV- 513
                 A   G L++GD+++A++         E+   LL+ + +T K+T+  E   +++V 
Sbjct: 1512 TEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVP 1571

Query: 514  ------------------IPSSG---------TFHVKLP--------------------- 525
                              +P SG         T     P                     
Sbjct: 1572 SAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIE 1631

Query: 526  -KKHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSM 584
              K    LG++I   S    G  ++I ++ +   A + G L  GD++L ++ I L   + 
Sbjct: 1632 ISKGRTGLGLSIVGGSDTLLG-AIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATH 1690

Query: 585  EDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVEL-KRYGGPLGITISGTEEPFD 643
            ++A+ +L+Q    V+L + +DE    E+E    +  T+EL K+ G  LG++I G      
Sbjct: 1691 DEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTL--TIELQKKPGKGLGLSIVGKRND-T 1747

Query: 644  PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAG---ETVTLKIK 700
             + +S + KGG+A+  G +  GD+IL +N   ++         LL+++     + T  + 
Sbjct: 1748 GVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFTFPLS 1807

Query: 701  KQTDAQS-ASSPKKFPISSHLSDLGDVEEDSSPAQKPG 737
              + ++S  SS KK  ++S +  L  VE    P    G
Sbjct: 1808 GSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLG 1845



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 58/221 (26%), Positives = 107/221 (48%), Gaps = 27/221 (12%)

Query: 40   RRQSIPEEFKGSTVVELMKKEGTTLGLTVSGGIDK---DGKPRVSNLRQGGIAARSDQLD 96
            ++ ++  E +G   VE+ K    +LG++++GG+     D    ++ +   G+AA++ +L 
Sbjct: 1820 KKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLR 1879

Query: 97   VGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVE----------YELPPVSVQ---- 142
            VGD I  + G +     H + ++LLKN    + ++V           ++  P S      
Sbjct: 1880 VGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFT 1939

Query: 143  --GSSVIFRT-------VEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADR 193
               SS IF+          +TL +  +  GF I GG +   +   P+ +  V   G A  
Sbjct: 1940 GLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGG-YGSPHGDLPIYVKTVFAKGAASE 1998

Query: 194  EGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLI 234
            +G +K GD++++V+G  L G TH EA++ILK+      L++
Sbjct: 1999 DGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 147/708 (20%), Positives = 267/708 (37%), Gaps = 154/708 (21%)

Query: 115 DEIISLLKNVGERVVLEVEYEL--PPVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHD 172
           DE   L+KN+ +   +EV +EL  PP    G SV+                     G   
Sbjct: 120 DEFDQLIKNMAQGRHVEV-FELLKPPSGGLGFSVV---------------------GLRS 157

Query: 173 DRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGT-THAEAMSILKQCGQEAA 231
           +      + +  ++ G  A R+G +K  D++L+++G  L  T TH +A+SIL++      
Sbjct: 158 ENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISILQKAKDTVQ 217

Query: 232 LLI-------------EYDVSVMDSVATASGPLLVEVAKT-----PGASLGVALTTSMCC 273
           L+I                 S   +++  S P+  +  +T      G+ LG  +      
Sbjct: 218 LVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKAT 277

Query: 274 NKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEIL 333
               +++  I    +AD+ G L  GDHIL I  T +   +  +  Q L    ++VKL I 
Sbjct: 278 G---VIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIA 334

Query: 334 PHHQTRLALKGPDHAALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKK 393
                            +    +PT++   +LSS    T    + +++ +G         
Sbjct: 335 --------------RGAIEERTAPTAL-GITLSSSPTSTPELRVDASTQKGE-------- 371

Query: 394 KDFKSSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISY 453
                                 +ET +V LT + V G GI + G +   +   S   +  
Sbjct: 372 ---------------------ESETFDVELTKN-VQGLGITIAGYIGDKKLEPSGIFVKS 409

Query: 454 IEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTL-------EIE 506
           I   S  E  G +QIGD+++A++G   +  T ++A ++LR +  T  +TL       E E
Sbjct: 410 ITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAE 469

Query: 507 FDVAESVIPSSGTFHVKLPKKHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLE 566
               E V   +    V            +I   +  K  D   +S  +  ++     T E
Sbjct: 470 LMSREDVTKDADLSPV----------NASIIKENYEKDED--FLSSTRNTNI---LPTEE 514

Query: 567 LGDKLLAIDNIRLDNCSMEDAV------QILQQCEDLVKLKIRKDEDNSDEQESSGAIIY 620
            G  LL+ +   +++   ++A       +I+    ++V   + K  +NS           
Sbjct: 515 EGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSG---------- 564

Query: 621 TVELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKP 680
                     LGI++  T        I S+   G    +G +  GD +L +N  +L G+ 
Sbjct: 565 ----------LGISLEAT---VGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGEN 611

Query: 681 LSEAIHLLQMAGETVTLKIKKQTDAQSASSPK--------KFPISSHLSDLGDVEEDSSP 732
             + +++L+     VT+   ++T   +  S          +     H+ DLG+    S  
Sbjct: 612 HQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHV-DLGEFIGSSET 670

Query: 733 AQKPGKLSDMYPSTVPSVDSAVDSWDGSA--IDTSYGTQGTSFQASGY 778
                 ++D   ST   V + +  W+     I+   G++G  F    Y
Sbjct: 671 EDPVLAMTDAGQST-EEVQAPLAMWEAGIQHIELEKGSKGLGFSILDY 717



 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 99/365 (27%), Positives = 153/365 (41%), Gaps = 53/365 (14%)

Query: 13   LRRLTKDESPYTKSASQTKPPDGALAVRRQSIP---EEFKGSTVVELMKKEGTTLGLTVS 69
            LR+ T DE+    +  +  P    L + R   P   EE   +  +EL KK G  LGL++ 
Sbjct: 1685 LRKATHDEAI---NVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIV 1741

Query: 70   GGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVV 129
            G  +  G   VS++ +GGIA    +L  GD I  VNG ++     + + +LLK V E  +
Sbjct: 1742 GKRNDTG-VFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLK-VSEGSL 1799

Query: 130  LEVEYELPPVSVQGS-----------SVI--FRTVEVTLHKEGNT--FGFVIRGGAHDDR 174
                + L   S   S           S I   RTVE+   K+G T   G  I GG     
Sbjct: 1800 SSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEM---KKGPTDSLGISIAGGVGSPL 1856

Query: 175  NKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQ--EAAL 232
                P+ I  + P G A +   ++ GDR++++ G    G TH +A+++LK      E  +
Sbjct: 1857 G-DVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQV 1915

Query: 233  LIEYDVSVM----DSVATAS----------------GP---LLVEVAKTP-GASLGVALT 268
            +   DVSV+       A++S                GP     + + + P G    +   
Sbjct: 1916 VAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGG 1975

Query: 269  TSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQV 328
                     I +  + +   A   G L  GD I++++G S+E  T  EA   L  T   V
Sbjct: 1976 YGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTV 2035

Query: 329  KLEIL 333
             L +L
Sbjct: 2036 TLMVL 2040



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 137/620 (22%), Positives = 237/620 (38%), Gaps = 120/620 (19%)

Query: 469  GDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKH 528
            G  +  ING P  D    E  QL+++ +    V      +V E + P SG          
Sbjct: 107  GPGIPHINGKPACD----EFDQLIKNMAQGRHV------EVFELLKPPSGG--------- 147

Query: 529  NVELGITISSPSSRKPGD-PLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNC-SMED 586
               LG ++    S   G+  + + +I++GSVAHR G L+  D++LAI+   LD   + + 
Sbjct: 148  ---LGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQ 204

Query: 587  AVQILQQCEDLVKLKI--------------RKDEDNSDEQESSGAIIY----TVELKRYG 628
            A+ ILQ+ +D V+L I              R     S     S  + +    T+EL   G
Sbjct: 205  AISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDG 264

Query: 629  GPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLL 688
              LG  I G +     +I+ ++  GG+A++ G +  GD IL I  + L G    +   +L
Sbjct: 265  SGLGFGIIGGKAT--GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVL 322

Query: 689  QMAGETVTLKIKKQTDAQSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDMYPSTVP 748
            +  G  V L I +                      G +EE ++P      LS   P++ P
Sbjct: 323  RQCGNRVKLMIAR----------------------GAIEERTAPTALGITLSSS-PTSTP 359

Query: 749  S--VDSAVDSWDGSA---IDTSYGTQGTSFQASGYNFNTYDWRSPKQRGSLSPVTKPRSQ 803
               VD++    + S    ++ +   QG     +GY     D +       +  +TK  + 
Sbjct: 360  ELRVDASTQKGEESETFDVELTKNVQGLGITIAGY---IGDKKLEPSGIFVKSITKSSAV 416

Query: 804  TYP---DVGLSYEDWDRSTASGFAGAADSAETEQEENFWSQALEDLETCGQSGILRELEE 860
             +     +G      D +   GF                 QA+E L   GQ+ +L  +  
Sbjct: 417  EHDGRIQIGDQIIAVDGTNLQGFTN--------------QQAVEVLRHTGQTVLLTLMR- 461

Query: 861  KADRRVSLRNMTLLATIMSGSTMSLNHEAPTPRSQLGRQASFQERSSSRPHYSQTTRSNT 920
                    R M   A +MS   ++ + +     S +      +         S T  +N 
Sbjct: 462  --------RGMKQEAELMSREDVTKDADL----SPVNASIIKENYEKDEDFLSSTRNTNI 509

Query: 921  LPSDVGRKSVTLRKMKQEIKEIMSPTPVELHK-----------VTLYKDSDMEDFGFSVA 969
            LP++     +   ++ +EI++        L K           V  +     E+ G  ++
Sbjct: 510  LPTEEEGYPLLSAEI-EEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGIS 568

Query: 970  DGLLEKGVYVKNIRPAGP-GDLGGLKPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDL 1028
                    +++++ P GP G  G L   D LL+VN +     +   VV ++ E   ++ +
Sbjct: 569  LEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTM 628

Query: 1029 VISRN--PLASQKSIDQQSL 1046
            V  R   P  +Q  +D   L
Sbjct: 629  VCCRRTVPPTTQSELDSLDL 648



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 78/323 (24%), Positives = 139/323 (43%), Gaps = 45/323 (13%)

Query: 417  ETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAIN 476
            +T  + L   P  G G+ + G    T        +S I     A+  G L  GD+++ +N
Sbjct: 1722 DTLTIELQKKPGKGLGLSIVGKRNDTGVF-----VSDIVKGGIADADGRLMQGDQILMVN 1776

Query: 477  GIPTEDSTFEEASQLLR--DSSITSKVTLEIEFDVAESVIPSS----------GTFHVKL 524
            G    ++T E  + LL+  + S++S          +ES+  SS          G   V++
Sbjct: 1777 GEDVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEM 1836

Query: 525  PKKHNVELGITISSPSSRKPGD-PLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCS 583
             K     LGI+I+       GD P+ I+ +    VA +T  L +GD+++ I     +  +
Sbjct: 1837 KKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMT 1896

Query: 584  MEDAVQILQQCEDLVKLKIRKDEDNS-----DEQESSGAIIYT----------------- 621
               AV +L+     +++++    D S      ++ +S ++ +T                 
Sbjct: 1897 HTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQC 1956

Query: 622  --VELKRYGGPLGITI-SGTEEPFD--PIIISSLTKGGLAERTGAIHIGDRILAINSSSL 676
              + L+R    LG +I  G   P    PI + ++   G A   G +  GD+I+A+N  SL
Sbjct: 1957 KSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSL 2016

Query: 677  KGKPLSEAIHLLQMAGETVTLKI 699
            +G    EA+ +L+    TVTL +
Sbjct: 2017 EGVTHEEAVAILKRTKGTVTLMV 2039



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 133/686 (19%), Positives = 252/686 (36%), Gaps = 174/686 (25%)

Query: 180  VVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQ-------------- 225
            +++  +  GG   R+G I  GD +LS++    +  T+A+A ++L++              
Sbjct: 1031 MIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLRRHSLIGPDIKITYVP 1090

Query: 226  ----------CGQEAALLIEYDV----------------------SVMDSVATA--SGPL 251
                       GQ++  ++  D+                      S + + A +  + P 
Sbjct: 1091 AEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPR 1150

Query: 252  LVEVAKTPGASLGVALT-----TSMCCNKQV---IVIDKIKSASIADRCGALHVGDHILS 303
             VE+ + P  SLG+++       S   N +V   I I  +   S A + G L  GD I+ 
Sbjct: 1151 RVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVE 1210

Query: 304  IDGTSMEYCTLAEATQFLANTTDQV--KLEILPHHQTRLALKGPDHAALVSSSFSPTSMS 361
            +DG  +   +  +A + +    + V   ++ + +   +  L    H      +FS T+  
Sbjct: 1211 VDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPF 1270

Query: 362  AYSLSSLNMGTLPRS---------LYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQ 412
            A SL  +N    P           L S  P        +     +SS S  S  V    +
Sbjct: 1271 ADSL-QINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDE 1329

Query: 413  VVH------------TETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPA 460
              +            T    ++      +G G+ L G+    +       I  I+ +  A
Sbjct: 1330 FGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGN---KDRSRMSVFIVGIDPNGAA 1386

Query: 461  ERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVAESV------- 513
             + G LQI D ++ ING      + + AS +++ +    K+      D    +       
Sbjct: 1387 GKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNA 1446

Query: 514  ---IPSS--------------------------GTFHVKLPKKHNVELGITISSPSSRKP 544
               +PS+                             H++LPK     LGI IS   +   
Sbjct: 1447 VEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQG-GLGIAISEEDTL-- 1503

Query: 545  GDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRK 604
               ++I  + +  VA   G L++GD++LA+D+  +    +E  + +L+  +  VKL I  
Sbjct: 1504 -SGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHA 1562

Query: 605  DEDNS------------DEQESSGAIIY-------------------------------- 620
            +  +S            +++ SS +++                                 
Sbjct: 1563 ENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPI 1622

Query: 621  ------TVELKRYGGPLGITI-SGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINS 673
                  T+E+ +    LG++I  G++     III  + + G A + G +  GD+IL +N 
Sbjct: 1623 IPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNG 1682

Query: 674  SSLKGKPLSEAIHLLQMAGETVTLKI 699
              L+     EAI++L+   + V L +
Sbjct: 1683 IDLRKATHDEAINVLRQTPQRVRLTL 1708



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 71/297 (23%), Positives = 127/297 (42%), Gaps = 43/297 (14%)

Query: 495  SSITSKVTLEIEF-----DVAESVIPSSGTFHVKLPKKHNVELGITISSPSSRKPGDPLV 549
            S I+  V  E EF     ++ E     +G  H+   +K +  LG++++    R      +
Sbjct: 1318 SKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFI 1377

Query: 550  ISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDED-- 607
            +  I     A + G L++ D+LL I+   L   S ++A  I++     VK+   +++D  
Sbjct: 1378 VG-IDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAV 1436

Query: 608  ----------------NSDEQE-----------------SSGAIIYTVELKRYGGPLGIT 634
                            NS+  +                 SS   +  +EL +  G LGI 
Sbjct: 1437 NQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIA 1496

Query: 635  ISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGET 694
            IS  E+    +II SLT+ G+A   G + +GD+ILA++   + G P+ + I LL+ A  T
Sbjct: 1497 IS-EEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMT 1555

Query: 695  VTLKIKKQT-DAQSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDMYPSTVPSV 750
            V L I  +  D+Q+  S          +    +    S + +P  + +   S+ P++
Sbjct: 1556 VKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAI 1612



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 102/478 (21%), Positives = 187/478 (39%), Gaps = 63/478 (13%)

Query: 24  TKSASQTKPPDGALAVRRQSIPEEFKGSTVVELMKKEGTTLGLTVSGGI-DKDGKPR--- 79
           T S+S T  P+  L V   +   E   +  VEL K     LG+T++G I DK  +P    
Sbjct: 350 TLSSSPTSTPE--LRVDASTQKGEESETFDVELTKNV-QGLGITIAGYIGDKKLEPSGIF 406

Query: 80  VSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEYELPPV 139
           V ++ +        ++ +GD I AV+G NL  F + + + +L++ G+ V+L     L   
Sbjct: 407 VKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLL----TLMRR 462

Query: 140 SVQGSSVIFRTVEVTLHKE-GNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIK 198
            ++  + +    +VT   +       +I+     D +       T + P        T +
Sbjct: 463 GMKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFLSSTRNTNILP--------TEE 514

Query: 199 PGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYD--VSVMDSVATASGPLLVEVA 256
            G  LLS           AE   I     QEAALL ++   + +   +  A       V+
Sbjct: 515 EGYPLLS-----------AEIEEIEDAQKQEAALLTKWQRIMGINYEIVVA------HVS 557

Query: 257 K-TPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLA 315
           K +  + LG++L  ++  +     I  +         G L  GD +L ++G ++    L 
Sbjct: 558 KFSENSGLGISLEATVGHH----FIRSVLPEGPVGHSGKLFSGDELLEVNGITL----LG 609

Query: 316 EATQFLANTTDQVKLEILPHHQTRLALKGPDHAALVSSSFSPTSMSAYSLSSLNMGTLPR 375
           E  Q + N   ++ +E+      R     P        S     +       +++G    
Sbjct: 610 ENHQDVVNILKELPIEVTMVCCRRTV---PPTTQSELDSLDLCDIELTEKPHVDLGEFIG 666

Query: 376 SLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQL 435
           S  +  P   M       ++ ++ L++  + +    Q +  E            G G  +
Sbjct: 667 SSETEDPVLAMTDAGQSTEEVQAPLAMWEAGI----QHIELEKGS--------KGLGFSI 714

Query: 436 QGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLR 493
                  +  S+  +I  +     AE+ G L  GDR+M +N +  E+S+ EEA + L+
Sbjct: 715 LDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALK 772



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 57/272 (20%), Positives = 112/272 (41%), Gaps = 32/272 (11%)

Query: 228  QEAALLIEYDVSVMDSVATASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIKSAS 287
            ++++L    +  ++ +V+  S    + +AK   +SLG  +T S   +   +++  I    
Sbjct: 984  EQSSLACNAECVMLQNVSKESFERTINIAKG-NSSLG--MTVSANKDGLGMIVRSIIHGG 1040

Query: 288  IADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDH 347
               R G + +GD ILSI+  S    T A+A   L                 R +L GPD 
Sbjct: 1041 AISRDGRIAIGDCILSINEESTISVTNAQARAMLR----------------RHSLIGPD- 1083

Query: 348  AALVSSSFSPTS-MSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASST 406
               +  ++ P   +  + +S   +G     + +     +   R + +   +       S 
Sbjct: 1084 ---IKITYVPAEHLEEFKIS---LGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESE 1137

Query: 407  VGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPL-----ISYIEADSPAE 461
            +         +   V L  +P    GI + G       LS+  +     I ++  DSPA 
Sbjct: 1138 LQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAG 1197

Query: 462  RCGVLQIGDRVMAINGIPTEDSTFEEASQLLR 493
            + G L+ GDR++ ++G+   D++ E+A + +R
Sbjct: 1198 KNGTLKPGDRIVEVDGMDLRDASHEQAVEAIR 1229



 Score = 37.7 bits (86), Expect = 0.059
 Identities = 20/55 (36%), Positives = 31/55 (56%), Gaps = 1/55 (1%)

Query: 621  TVELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSS 675
            T+ + +    LG+T+S  ++    +I+ S+  GG   R G I IGD IL+IN  S
Sbjct: 1008 TINIAKGNSSLGMTVSANKDGLG-MIVRSIIHGGAISRDGRIAIGDCILSINEES 1061



 Score = 35.4 bits (80), Expect = 0.29
 Identities = 19/67 (28%), Positives = 39/67 (58%), Gaps = 1/67 (1%)

Query: 965  GFSVADGLLEKGVYVKNIRPAGP-GDLGGLKPYDRLLQVNHVRTRDFDCCLVVPLIAESG 1023
            G  +++G + +G+++K++    P G  G LKP DR+++V+ +  RD      V  I ++G
Sbjct: 1173 GSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAG 1232

Query: 1024 NKLDLVI 1030
            N +  ++
Sbjct: 1233 NPVVFMV 1239


>gi|112382257 InaD-like [Homo sapiens]
          Length = 1801

 Score =  112 bits (279), Expect = 2e-24
 Identities = 166/751 (22%), Positives = 299/751 (39%), Gaps = 142/751 (18%)

Query: 53   VVELMKKEGTTLGLTVSGGID-----KDGKPR----VSNLRQGGIAARSDQLDVGDYIKA 103
            +VE+ ++   +LG+++ GG       K+G+      +  + +   A +++ L  GD I  
Sbjct: 1068 IVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILE 1127

Query: 104  VNGINLAKFRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKEGNTFG 163
            V+G++L    H E +  +KN G  VV  V+      S+  +  +   V    H + N   
Sbjct: 1128 VSGVDLQNASHSEAVEAIKNAGNPVVFIVQ------SLSSTPRVIPNV----HNKANK-- 1175

Query: 164  FVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSIL 223
              I G  + D  + +              R+GT  P  +L              +A++  
Sbjct: 1176 --ITGNQNQDTQEKKE------------KRQGTAPPPMKL----------PPPYKALTDD 1211

Query: 224  KQCGQEAALLIEYDVSVMDSVATASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKI 283
                +E       D  +    A   G L +   +     LG++L  +   ++  I +  I
Sbjct: 1212 SDENEEEDAFT--DQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGI 1269

Query: 284  KSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALK 343
                 A   G + +GD +L I+   +   +   A+  +     +VKL  + +     A+ 
Sbjct: 1270 NPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNED---AVN 1326

Query: 344  GPDHAALVSSSFSPTSMSAYS----LSSLNMGTLPRSLYST--SPRGTMMRRRLKKKDFK 397
                      S SP+S+   S    +SS   G++   +     S    +   ++K++ + 
Sbjct: 1327 QMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKYP 1386

Query: 398  SSLSLASSTVGLAGQVVHTETT---------EVVLTADPVT------------------G 430
            + +S +S  + LA    +  T          +  L+ DP T                  G
Sbjct: 1387 TKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSG 1446

Query: 431  FGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQ 490
             G+ + G     +T  +  +I  +  +  A R G L  GD+++ +NG+   +S+ EEA  
Sbjct: 1447 LGLSIVGG---KDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAIT 1503

Query: 491  LLRDSSITSKVTLEIEFDVAESVIPSS-GTFHVKLPKKHNVELGITISSPSSRKPGDPLV 549
             LR +    KV L +  D A      +   F V L KK    LG++I     ++ G  + 
Sbjct: 1504 ALRQTP--QKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVG---KRNGSGVF 1558

Query: 550  ISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKI------- 602
            ISDI KG  A   G L  GD++L+++   + N S E    IL+  + LV+L+I       
Sbjct: 1559 ISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGS 1618

Query: 603  ----RKDEDNSD---------------------------------EQESSGAII--YTVE 623
                R    NS                                   Q++SG  +   TVE
Sbjct: 1619 WTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVE 1678

Query: 624  LKR-YGGPLGITISGTE-EPFD--PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGK 679
            + R     LGI+I+G    P    P+ I+ +   G+A RT  + +GDRI++IN   L G 
Sbjct: 1679 INRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGL 1738

Query: 680  PLSEAIHLLQMAGETVTLKIKKQTDAQSASS 710
              ++ ++LL+ A   + L++   T+  + ++
Sbjct: 1739 SHADVVNLLKNAYGRIILQVVADTNISAIAA 1769



 Score =  104 bits (259), Expect = 5e-22
 Identities = 146/628 (23%), Positives = 244/628 (38%), Gaps = 107/628 (17%)

Query: 80  VSNLRQGGIAARSDQLDVGDYIKAVNGINLAK-FRHDEIISLLKNVGERVVLEVEYELPP 138
           V +++ G +A R  +L   D I A+N   L +   H + I+LL+     + L V  E   
Sbjct: 164 VKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVH 223

Query: 139 VSVQGSSVIFRTV-----------EVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRP 187
                SS +  T            EV L  +G+  GF I GG      K+  VV+  + P
Sbjct: 224 TKSSTSSSLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGG------KTSGVVVRTIVP 277

Query: 188 GGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEY----DVSVMDS 243
           GG ADR+G ++ GD +L + G  + G T  +   +L+ CG    +L+      D+SV   
Sbjct: 278 GGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPP 337

Query: 244 VATA----------SGP---------LLVEVAKTPGASLGVALT----TSMCCNKQVIVI 280
              A           GP           VE+ +  G SLG+ +     TS       I +
Sbjct: 338 APAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYV 397

Query: 281 DKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPH--HQT 338
             I   S A   G + V D I+++DG +++     +  + L N    V L ++      +
Sbjct: 398 KSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSS 457

Query: 339 RLALKGPDHAALVSSSFSPTSMSAYSLSSLNMGT------LPRSLYSTSPRGTMMRRRLK 392
              L+ P     V     P ++                  +   + +          +L+
Sbjct: 458 TSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLE 517

Query: 393 KKDFKSSLSLASSTVGLAGQ----VVHTETTEVVLTAD--------PVTGFGIQLQGSVF 440
           K        L S    L G     +V T  T++   A+        P+    + ++    
Sbjct: 518 KVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVE---- 573

Query: 441 ATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRD-----S 495
             ++      IS I +  P +  G+LQ  D ++ +NG+     +  EA   L++     +
Sbjct: 574 -VDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFT 632

Query: 496 SITSKVTLEIEFDV-----AESVIPSS---------------GTFHVKLPKKHNVEL--- 532
            +  +   + E  V      E+ +P +               G   +  P+   VEL   
Sbjct: 633 LVCCRRLFDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKD 692

Query: 533 --GITISSPSSRKPGDP----LVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMED 586
             G+  S    + P DP    +VI  +    VA R+G L  GD+L++++   LDN S+ +
Sbjct: 693 CKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAE 752

Query: 587 AVQILQQC-EDLVKLKIRKD--EDNSDE 611
           AV+IL+     LV L I K   EDN +E
Sbjct: 753 AVEILKAVPPGLVHLGICKPLVEDNEEE 780



 Score = 87.4 bits (215), Expect = 6e-17
 Identities = 127/606 (20%), Positives = 231/606 (38%), Gaps = 105/606 (17%)

Query: 180 VVITCVRPGGPADREGTIKPGDRLLSVDGIRL-LGTTHAEAMSILKQCGQEAALLIEYDV 238
           + +  V+PG  ADR+  +K  D++L+++   L    +H +A+++L+Q      L++  + 
Sbjct: 162 IFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREP 221

Query: 239 SVMDSVATAS------------GPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIKSA 286
               S  ++S            G +        G+ LG  +          +V+  I   
Sbjct: 222 VHTKSSTSSSLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGGKTSG---VVVRTIVPG 278

Query: 287 SIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPD 346
            +ADR G L  GDHIL I GT+++  T  +  Q L N  + V++ +       +++  P 
Sbjct: 279 GLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPA 338

Query: 347 HAALV--------------SSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLK 392
            AAL               SS F   ++        ++G        TS  G      +K
Sbjct: 339 PAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVK 398

Query: 393 KKDFKSSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLIS 452
                 S +  +  + +  ++V  +   +   A+      ++  G V     +      S
Sbjct: 399 SI-IPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSS 457

Query: 453 YIEADSPAERCGVLQ--------IGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLE 504
               + P++R  V++        +   V     +  ED   +E    L++ +I +   LE
Sbjct: 458 TSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLE 517

Query: 505 IEFDVAESVIPSSGTF-------------------------HVKLPKKHNVELGITISSP 539
              D  E+ + S                             + KL   H + LG+ + S 
Sbjct: 518 KVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSF 577

Query: 540 SSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQ------ 593
                     IS I  G      G L+  D+LL ++ ++L   S  +AV  L++      
Sbjct: 578 DGHH-----YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFT 632

Query: 594 ---CEDLVKLKIRKDE-----------------DNSDEQESSGAI------IYTVELKRY 627
              C  L   +   DE                 D + E++  G +      +  VEL + 
Sbjct: 633 LVCCRRLFDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKD 692

Query: 628 GGPLGITISGTEEPFDP----IIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSE 683
              LG +I   ++P DP    I+I SL   G+AER+G +  GDR++++N   L    L+E
Sbjct: 693 CKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAE 752

Query: 684 AIHLLQ 689
           A+ +L+
Sbjct: 753 AVEILK 758



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 64/224 (28%), Positives = 109/224 (48%), Gaps = 24/224 (10%)

Query: 544  PGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIR 603
            P + +VI ++ +   A R G L  GD++L ++ + L N S E+A+  L+Q    V+L + 
Sbjct: 1458 PLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVY 1517

Query: 604  KDEDNSDEQESSGAIIYTVEL-KRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAI 662
            +DE +  ++E+    I+ V+L K+ G  LG++I G       + IS + KGG A+  G +
Sbjct: 1518 RDEAHYRDEEN--LEIFPVDLQKKAGRGLGLSIVGKRNG-SGVFISDIVKGGAADLDGRL 1574

Query: 663  HIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKK-------------------QT 703
              GD+IL++N   ++         +L+ A   V L+I +                   Q 
Sbjct: 1575 IQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQ 1634

Query: 704  DAQSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDMYPSTV 747
             A S+  P   P+ + L +L   +  S P+QK    +DM P TV
Sbjct: 1635 SAHSSCHPSFAPVITGLQNLVGTKRVSDPSQK-NSGTDMEPRTV 1677



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 104/418 (24%), Positives = 175/418 (41%), Gaps = 49/418 (11%)

Query: 125  GERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITC 184
            G +  L V+    P+ V G  +I   +E++  + G   G  I GG     N    +VI  
Sbjct: 1416 GFQAPLSVDPATCPI-VPGQEMI---IEISKGRSG--LGLSIVGGKDTPLNA---IVIHE 1466

Query: 185  VRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVS-VMDS 243
            V   G A R+G +  GD++L V+G+ L  ++H EA++ L+Q  Q+  L++  D +   D 
Sbjct: 1467 VYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDE 1526

Query: 244  VATASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILS 303
                  P  V++ K  G  LG+++      N   + I  I     AD  G L  GD ILS
Sbjct: 1527 ENLEIFP--VDLQKKAGRGLGLSIVGKR--NGSGVFISDIVKGGAADLDGRLIQGDQILS 1582

Query: 304  IDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHAALVSSSFSPTSMSAY 363
            ++G  M   +       L      V+LEI      RL       A   S +   +  SA+
Sbjct: 1583 VNGEDMRNASQETVATILKCAQGLVQLEI-----GRLRAGSWTSARTTSQNSQGSQQSAH 1637

Query: 364  SLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQVVHTETTEVVL 423
            S    +   +   L +    GT   +R+     K+S           G  +   T E+  
Sbjct: 1638 SSCHPSFAPVITGLQNLV--GT---KRVSDPSQKNS-----------GTDMEPRTVEI-- 1679

Query: 424  TADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDS 483
              +     GI + G    +     P  I+ I+A   A R   L++GDR+++ING P +  
Sbjct: 1680 NRELSDALGISIAGGR-GSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGL 1738

Query: 484  TFEEASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITISSPSS 541
            +  +   LL+++    ++ L++  D   S I +         +  N+  G  + SP++
Sbjct: 1739 SHADVVNLLKNA--YGRIILQVVADTNISAIAA---------QLENMSTGYHLGSPTA 1785



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 93/420 (22%), Positives = 176/420 (41%), Gaps = 62/420 (14%)

Query: 355 FSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTM-MRRRLKKKDFKSSLSLASSTVGLAGQV 413
           FS   +  ++  S+  G + R   +++  G      +L  +DF S +           Q+
Sbjct: 77  FSRKGLLVFTDGSITNGNVHRPSNNSTVSGLFPWTPKLGNEDFNSVIQ----------QM 126

Query: 414 VHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPL-ISYIEADSPAERCGVLQIGDRV 472
                 E +    P TG G+        ++ L    + +  ++  S A+R   L+  D++
Sbjct: 127 AQGRQIEYIDIERPSTG-GLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQI 185

Query: 473 MAINGIPTEDS-TFEEASQLLRDSSITSKVTLEIE---------FDVAESVIPSSGTF-H 521
           +AIN  P + + + ++A  LL+ ++ + ++ +  E           + ++ +P +  + H
Sbjct: 186 LAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGH 245

Query: 522 VKLPKKHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDN 581
           V+  +  N   G+       +  G  +V+  I  G +A R G L+ GD +L I    +  
Sbjct: 246 VEEVELINDGSGLGFGIVGGKTSG--VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQG 303

Query: 582 CSMEDAVQILQQCEDLVKLKIRKDE----------------------DNSDEQESSGAII 619
            + E   Q+L+ C + V++ + +D                             +SS    
Sbjct: 304 MTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSLFET 363

Query: 620 YTVELKRYGGP-LGITISG------TEEPFDPIIISSLTKGGLAERTGAIHIGDRILAIN 672
           Y VEL R  G  LGI I G      T E    I + S+  G  A   G I + D+I+A++
Sbjct: 364 YNVELVRKDGQSLGIRIVGYVGTSHTGEA-SGIYVKSIIPGSAAYHNGHIQVNDKIVAVD 422

Query: 673 SSSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQSASSPKKFPISSHLSDLGDVEEDSSP 732
             +++G    + + +L+ AG+ V L + ++    S++SP + P     SD G V E   P
Sbjct: 423 GVNIQGFANHDVVEVLRNAGQVVHLTLVRR-KTSSSTSPLEPP-----SDRGTVVEPLKP 476



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 81/339 (23%), Positives = 139/339 (41%), Gaps = 67/339 (19%)

Query: 50   GSTVVELMKKEGTTLGLTVSGGIDKDGKPRVSN-LRQGGIAARSDQLDVGDYIKAVNGIN 108
            G  ++  + K  + LGL++ GG D      V + + + G AAR  +L  GD I  VNG++
Sbjct: 1433 GQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVD 1492

Query: 109  LAKFRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKE-GNTFGFVIR 167
            L    H+E I+ L+   ++V L V  +      + +  IF    V L K+ G   G  I 
Sbjct: 1493 LRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIF---PVDLQKKAGRGLGLSIV 1549

Query: 168  GGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCG 227
            G     +     V I+ +  GG AD +G +  GD++LSV+G  +   +     +ILK C 
Sbjct: 1550 G-----KRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILK-CA 1603

Query: 228  QEAALLIEYDVS-----------------------------------------------V 240
            Q    L++ ++                                                V
Sbjct: 1604 QG---LVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRV 1660

Query: 241  MDSVATASG----PLLVEVAKTPGASLGVALT--TSMCCNKQVIVIDKIKSASIADRCGA 294
             D     SG    P  VE+ +    +LG+++            + I  I+++ +A R   
Sbjct: 1661 SDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQK 1720

Query: 295  LHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEIL 333
            L VGD I+SI+G  ++  + A+    L N   ++ L+++
Sbjct: 1721 LKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVV 1759



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 96/490 (19%), Positives = 186/490 (37%), Gaps = 79/490 (16%)

Query: 250  PLLVEVAKTPGASLGVALTTSMCCNKQV--------IVIDKIKSASIADRCGALHVGDHI 301
            P +VE+ + P  SLG+++       K++        I I ++   S A +  AL  GD I
Sbjct: 1066 PRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKI 1125

Query: 302  LSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHAALVSSSFSPTSMS 361
            L + G  ++  + +EA + + N  + V   +     T   +    + A  +      +  
Sbjct: 1126 LEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKA--NKITGNQNQD 1183

Query: 362  AYSLSSLNMGTLPRSLYSTSPRGTMM--RRRLKKKDFKSSLSLASSTVGLAGQVVHTETT 419
                     GT P  +    P   +       +++D  +   +      L G++      
Sbjct: 1184 TQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGEL------ 1237

Query: 420  EVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIP 479
             ++       G G+ L G+    +       +  I  + PA   G ++IGD ++ IN   
Sbjct: 1238 HIIELEKDKNGLGLSLAGN---KDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQI 1294

Query: 480  TEDSTFEEASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITISSP 539
                + + AS +++    T+   +++ F   E  +         +P           SSP
Sbjct: 1295 LYGRSHQNASAIIK----TAPSKVKLVFIRNEDAVNQMAVTPFPVPS----------SSP 1340

Query: 540  SS--RKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDL 597
            SS   + G   + S+          G++E+G K L       ++ S + AV  ++Q +  
Sbjct: 1341 SSIEDQSGTEPISSE--------EDGSVEVGIKQLP------ESESFKLAVSQMKQQKYP 1386

Query: 598  VKLKIRKDE--------DNSDEQESSG---------------AII----YTVELKRYGGP 630
             K+     E         +S + + +G                I+      +E+ +    
Sbjct: 1387 TKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSG 1446

Query: 631  LGITI-SGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQ 689
            LG++I  G + P + I+I  + + G A R G +  GD+IL +N   L+     EAI  L+
Sbjct: 1447 LGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALR 1506

Query: 690  MAGETVTLKI 699
               + V L +
Sbjct: 1507 QTPQKVRLVV 1516



 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 62/281 (22%), Positives = 111/281 (39%), Gaps = 74/281 (26%)

Query: 522  VKLPKKHNVELGITISSPSS----RKPGDPL---VISDIKKGSVAHRTGTLELGDKLLAI 574
            V++ ++ NV LGI+I    +     K G+ L    I  + + S A +T  L+ GDK+L +
Sbjct: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEV 1128

Query: 575  DNIRLDNCSMEDAVQILQ---------------------------------QCEDLVKLK 601
              + L N S  +AV+ ++                                 Q +D  + K
Sbjct: 1129 SGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKK 1188

Query: 602  IRKD----------------EDNSDEQESSGAI---------------IYTVELKRYGGP 630
             ++                  D+SDE E   A                ++ +EL++    
Sbjct: 1189 EKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNG 1248

Query: 631  LGITISGTEEPFD-PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQ 689
            LG++++G ++     I +  +   G A   G + IGD +L IN+  L G+    A  +++
Sbjct: 1249 LGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIK 1308

Query: 690  MAGETVTLKIKKQTDAQSASSPKKFPISSHLSDLGDVEEDS 730
             A   V L   +  DA +  +   FP+ S  S    +E+ S
Sbjct: 1309 TAPSKVKLVFIRNEDAVNQMAVTPFPVPS--SSPSSIEDQS 1347



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 31/104 (29%), Positives = 57/104 (54%), Gaps = 8/104 (7%)

Query: 37   LAVRRQSIPEEFKGST-----VVELMKKEGTTLGLTVSGGIDK---DGKPRVSNLRQGGI 88
            +  +R S P +    T      VE+ ++    LG++++GG      D    ++ ++  G+
Sbjct: 1655 VGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGV 1714

Query: 89   AARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEV 132
            AAR+ +L VGD I ++NG  L    H ++++LLKN   R++L+V
Sbjct: 1715 AARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQV 1758



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 34/115 (29%), Positives = 58/115 (50%), Gaps = 12/115 (10%)

Query: 28  SQTKPPDGALAVRRQSIPEEFKGSTV-------VELMKKEGTTLGLTVSG--GIDKDGKP 78
           S T P   AL V   ++  +  GS         VEL++K+G +LG+ + G  G    G+ 
Sbjct: 333 SVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEA 392

Query: 79  R---VSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVL 130
               V ++  G  A  +  + V D I AV+G+N+  F + +++ +L+N G+ V L
Sbjct: 393 SGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHL 447



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 31/124 (25%), Positives = 51/124 (41%), Gaps = 15/124 (12%)

Query: 937  QEIKEIMSPTPVELHKVTLYKDSDMEDFGFSVADGLLEKGVYVKNIRPAGPGDLGG-LKP 995
            Q+I++  +  P ELH + L KD +      +         ++V  I P GP    G ++ 
Sbjct: 1224 QKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRI 1283

Query: 996  YDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISRN--------------PLASQKSI 1041
             D LL++N+             +I  + +K+ LV  RN              P +S  SI
Sbjct: 1284 GDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSI 1343

Query: 1042 DQQS 1045
            + QS
Sbjct: 1344 EDQS 1347



 Score = 32.7 bits (73), Expect = 1.9
 Identities = 20/77 (25%), Positives = 36/77 (46%), Gaps = 2/77 (2%)

Query: 959  SDMEDFGFSVADGLLEKGVYVKNIRPAGPGDLGG-LKPYDRLLQVNHVRTRDFDCCLVVP 1017
            +D    GF +  G    GV V+ I P G  D  G L+  D +L++     +      V  
Sbjct: 253  NDGSGLGFGIVGGKTS-GVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQ 311

Query: 1018 LIAESGNKLDLVISRNP 1034
            ++   GN + ++++R+P
Sbjct: 312  VLRNCGNSVRMLVARDP 328


>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
          Length = 749

 Score =  107 bits (267), Expect = 6e-23
 Identities = 112/451 (24%), Positives = 195/451 (43%), Gaps = 47/451 (10%)

Query: 139 VSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRP-VVITCVRPGGPADREGTI 197
           + V G+ + +   E+TL +  +  GF I GG  +      P + IT + PGG A  +G +
Sbjct: 34  IPVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRL 93

Query: 198 KPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASGPLLVEVAK 257
           +  D +L V+ + +   +H++A+  LK+ G    L +     ++++V       L +  K
Sbjct: 94  RVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIK---LFKGPK 150

Query: 258 TPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEA 317
             G S+   +          I + KI     A + G L VGD +L ++  S+E  T  EA
Sbjct: 151 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 210

Query: 318 TQFLANTTDQVKLEILPHHQTRLALKGPDHAALVSSSFSPTSMSAYSLSSLNMGTLP--R 375
              L NT++ V L++     T + +  P     ++ S+SP  M  + LS  N GTL    
Sbjct: 211 VAILKNTSEVVYLKV--GKPTTIYMTDPYGPPDITHSYSPP-MENHLLSG-NNGTLEYKT 266

Query: 376 SLYSTSPR--GTMMRRRLKKKDFKSSLSLASST----------VGLAGQVVHTETTEVVL 423
           SL   SP     + +  L   D+ S    +++T          V L G     E  +VVL
Sbjct: 267 SLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEG-----EPRKVVL 321

Query: 424 TADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDS 483
                TG G  + G             +S+I A  PA+  G LQ GD+++++NGI    +
Sbjct: 322 HKGS-TGLGFNIVGGEDGEGIF-----VSFILAGGPADLSGELQRGDQILSVNGIDLRGA 375

Query: 484 TFEEASQLLRDSSITSKVTLEIE-----------FDVAESVI---PSSGTFHVKLPKKHN 529
           + E+A+  L+ +  T  +  + +            D+ E ++    SSG+  ++  +K +
Sbjct: 376 SHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRS 435

Query: 530 VELGITISSPSSRKPGDPLVISDIKKGSVAH 560
           + +        S+  G P      K G + H
Sbjct: 436 LYVRAMFDYDKSKDSGLPSQGLSFKYGDILH 466



 Score = 77.4 bits (189), Expect = 7e-14
 Identities = 58/204 (28%), Positives = 94/204 (46%), Gaps = 18/204 (8%)

Query: 37  LAVRRQSIPEEFKGSTVVELMKKEGTTLGLTVSGGIDK-----DGKPRVSNLRQGGIAAR 91
           + V    I  EF+  T    +++  + LG +++GG D      D    ++ +  GG AA 
Sbjct: 34  IPVNGTEIEYEFEEIT----LERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAE 89

Query: 92  SDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFRTV 151
             +L V D I  VN +++++  H + +  LK  G  V L V    P        ++   V
Sbjct: 90  DGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRP--------ILETVV 141

Query: 152 EVTLHKEGNTFGFVIRGGAHDDRNKS-RPVVITCVRPGGPADREGTIKPGDRLLSVDGIR 210
           E+ L K     GF I GG  +        + +T +  GG A ++G ++ GDRLL V+   
Sbjct: 142 EIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYS 201

Query: 211 LLGTTHAEAMSILKQCGQEAALLI 234
           L   TH EA++ILK   +   L +
Sbjct: 202 LEEVTHEEAVAILKNTSEVVYLKV 225



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 78/283 (27%), Positives = 131/283 (46%), Gaps = 44/283 (15%)

Query: 487 EASQLLRDSSITSKVTLEIEFDVAESVIPSSGT-----FHVKLPKKHNVELGITISSPSS 541
           E  QLL D+  + K   + E  +  + IP +GT     F     ++ N  LG +I+  + 
Sbjct: 10  ENYQLLWDTIASLK---QCEQAMQHAFIPVNGTEIEYEFEEITLERGNSGLGFSIAGGTD 66

Query: 542 RKP--GDP-LVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLV 598
                 DP + I+ I  G  A   G L + D +L ++ + +   S   AV+ L++   +V
Sbjct: 67  NPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIV 126

Query: 599 KLKIRKDEDNSDEQESSGAIIYTVELKRYGGP--LGITISG----TEEPFD-PIIISSLT 651
           +L +R+     +           VE+K + GP  LG +I+G       P D  I ++ + 
Sbjct: 127 RLYVRRRRPILET---------VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKII 177

Query: 652 KGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQT-------- 703
            GG A++ G + +GDR+L +N+ SL+     EA+ +L+   E V LK+ K T        
Sbjct: 178 DGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPY 237

Query: 704 ---DAQSASSPKKFPISSHL--SDLGDVE-EDSSPAQKPGKLS 740
              D   + SP   P+ +HL   + G +E + S P   PG+ S
Sbjct: 238 GPPDITHSYSP---PMENHLLSGNNGTLEYKTSLPPISPGRYS 277



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 60/245 (24%), Positives = 99/245 (40%), Gaps = 26/245 (10%)

Query: 460 AERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVAESVIPSSGT 519
           A++ G LQ+GDR++ +N    E+ T EEA  +L++   TS+V                  
Sbjct: 182 AQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKN---TSEVV----------------- 221

Query: 520 FHVKLPKKHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRL 579
            ++K+ K   + +      P       P + + +  G+     GTLE    L  I   R 
Sbjct: 222 -YLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGN----NGTLEYKTSLPPISPGRY 276

Query: 580 DNCSMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISGTE 639
                   V              R+         S       V L +    LG  I G E
Sbjct: 277 SPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGE 336

Query: 640 EPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKI 699
           +  + I +S +  GG A+ +G +  GD+IL++N   L+G    +A   L+ AG+TVT+  
Sbjct: 337 DG-EGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIA 395

Query: 700 KKQTD 704
           + Q +
Sbjct: 396 QYQPE 400



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 36/117 (30%), Positives = 62/117 (52%), Gaps = 6/117 (5%)

Query: 19  DESPYTKSASQTKPPDGALAVRRQSIPEEFKGSTVVELMKKEGTTLGLTVSGGIDKDGKP 78
           D + +++ ++ T+ P   L   ++++  E +   VV  + K  T LG  + GG D +G  
Sbjct: 288 DYTSHSQHSTATRQPSMTL---QRAVSLEGEPRKVV--LHKGSTGLGFNIVGGEDGEGI- 341

Query: 79  RVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEYE 135
            VS +  GG A  S +L  GD I +VNGI+L    H++  + LK  G+ V +  +Y+
Sbjct: 342 FVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQ 398



 Score = 38.1 bits (87), Expect = 0.045
 Identities = 35/136 (25%), Positives = 61/136 (44%), Gaps = 20/136 (14%)

Query: 877  IMSGSTMSLNHEAPTPRSQLGRQASFQERSSSRPHYSQTTRSNTL---PSDVGRKSVTLR 933
            ++SG+  +L ++   P    GR +   +       Y+  ++ +T    PS   +++V+L 
Sbjct: 254  LLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLE 313

Query: 934  KMKQEIKEIMSPTPVELHKVTLYKDSDMEDFGFSVADGLLEKGVYVKNIRPAGPGDLGG- 992
                           E  KV L+K S     GF++  G   +G++V  I   GP DL G 
Sbjct: 314  G--------------EPRKVVLHKGST--GLGFNIVGGEDGEGIFVSFILAGGPADLSGE 357

Query: 993  LKPYDRLLQVNHVRTR 1008
            L+  D++L VN +  R
Sbjct: 358  LQRGDQILSVNGIDLR 373



 Score = 30.8 bits (68), Expect = 7.2
 Identities = 24/91 (26%), Positives = 43/91 (47%), Gaps = 9/91 (9%)

Query: 949  ELHKVTLYKDSDMEDFGFSVADGLL------EKGVYVKNIRPAGPG-DLGGLKPYDRLLQ 1001
            E  ++TL + +     GFS+A G        + G+++  I P G   + G L+  D +L+
Sbjct: 44   EFEEITLERGNS--GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILR 101

Query: 1002 VNHVRTRDFDCCLVVPLIAESGNKLDLVISR 1032
            VN V   +      V  + E+G+ + L + R
Sbjct: 102  VNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 132


>gi|119943106 synapse-associated protein 102 isoform a [Homo
           sapiens]
          Length = 817

 Score = 97.1 bits (240), Expect = 8e-20
 Identities = 89/366 (24%), Positives = 154/366 (42%), Gaps = 45/366 (12%)

Query: 141 VQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRP-VVITCVRPGGPADREGTIKP 199
           V GS  +F+  E+ L +  +  GF I GG  +      P + IT + PGG A  +G +  
Sbjct: 120 VNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGV 179

Query: 200 GDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASGPLLVEVAKTP 259
            D +L V+ + +    H+ A+  LK+ G    L++       +++   +   L++  K  
Sbjct: 180 NDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVN---LLKGPKGL 236

Query: 260 GASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQ 319
           G S+   +          I I KI     A + G L +GD +L+++ T+++     EA  
Sbjct: 237 GFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVA 296

Query: 320 FLANTTDQVKLEILPHHQTRL--ALKGPDHA----ALVSSSFSPTSMSAY------SLSS 367
            L NT+D V L++       L      PD+A    AL  +  S  S   Y       +S 
Sbjct: 297 SLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSY 356

Query: 368 LNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQVVHTETTEVVLTADP 427
                +P + YS  PR  +      ++  K  + L   + GL   +V  E  E +     
Sbjct: 357 PAPPQVPPTRYSPIPRHMLAEEDFTREPRK--IILHKGSTGLGFNIVGGEDGEGIF---- 410

Query: 428 VTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEE 487
                                  +S+I A  PA+  G L+ GDR++++NG+   ++T E+
Sbjct: 411 -----------------------VSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQ 447

Query: 488 ASQLLR 493
           A+  L+
Sbjct: 448 AAAALK 453



 Score = 87.8 bits (216), Expect = 5e-17
 Identities = 72/263 (27%), Positives = 112/263 (42%), Gaps = 72/263 (27%)

Query: 37  LAVRRQSIPEEFKGSTVVELMKKEGTT-LGLTVSGGIDK-----DGKPRVSNLRQGGIAA 90
           L VRR+  P E    T++E+   +G   LG +++GGI       D    ++ + +GG A 
Sbjct: 212 LVVRRRQPPPE----TIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQ 267

Query: 91  RSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVL-------------------- 130
           +  +L +GD + AVN  NL   RH+E ++ LKN  + V L                    
Sbjct: 268 KDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYA 327

Query: 131 -------------------------EVEYELPP-VSVQGSSVIFRTV-----------EV 153
                                    +V Y  PP V     S I R +           ++
Sbjct: 328 STFTALADNHISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKI 387

Query: 154 TLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLG 213
            LHK     GF I GG   +      + ++ +  GGPAD  G ++ GDR+LSV+G+ L  
Sbjct: 388 ILHKGSTGLGFNIVGGEDGEG-----IFVSFILAGGPADLSGELRRGDRILSVNGVNLRN 442

Query: 214 TTHAEAMSILKQCGQEAALLIEY 236
            TH +A + LK+ GQ   ++ +Y
Sbjct: 443 ATHEQAAAALKRAGQSVTIVAQY 465



 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 87/373 (23%), Positives = 150/373 (40%), Gaps = 77/373 (20%)

Query: 429 TGFGIQLQGSVFATETLSSPPL-ISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEE 487
           +G G  + G +        P + I+ I     A   G L + D V+ +N +   +     
Sbjct: 139 SGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSR 198

Query: 488 ASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITISSPSSRK--PG 545
           A + L+++    ++ +       E+++  +    +K PK     LG +I+     +  PG
Sbjct: 199 AVEALKEAGPVVRLVVRRRQPPPETIMEVN---LLKGPKG----LGFSIAGGIGNQHIPG 251

Query: 546 D-PLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRK 604
           D  + I+ I +G  A + G L++GD+LLA++N  L +   E+AV  L+   D+V LK+ K
Sbjct: 252 DNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAK 311

Query: 605 D---------------------EDNSDEQESSGAIIYTVELK-RYGGP------------ 630
                                  DN     SS   +  VE K  Y  P            
Sbjct: 312 PGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIP 371

Query: 631 ------------------------LGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGD 666
                                   LG  I G E+  + I +S +  GG A+ +G +  GD
Sbjct: 372 RHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDG-EGIFVSFILAGGPADLSGELRRGD 430

Query: 667 RILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQSASSPKKFPISSHLSDLGDV 726
           RIL++N  +L+     +A   L+ AG++VT+  + + +  S          S + DL + 
Sbjct: 431 RILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSR-------FESKIHDLREQ 483

Query: 727 EEDSSPAQKPGKL 739
             +SS +   G L
Sbjct: 484 MMNSSMSSGSGSL 496



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 62/226 (27%), Positives = 107/226 (47%), Gaps = 30/226 (13%)

Query: 508 DVAESVIPSSGTFHVK--LPKKHNVELGITISS--PSSRKPGDP-LVISDIKKGSVAHRT 562
           D  E V  S G F  +  + ++ N  LG +I+    +   P DP + I+ I  G  A   
Sbjct: 115 DWYEQVNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMD 174

Query: 563 GTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTV 622
           G L + D +L ++ + +       AV+ L++   +V+L +R+ +   +        I  V
Sbjct: 175 GRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPET-------IMEV 227

Query: 623 ELKRYGGPLGITISG----TEEPFD-PIIISSLTKGGLAERTGAIHIGDRILAINSSSLK 677
            L +    LG +I+G       P D  I I+ + +GG A++ G + IGDR+LA+N+++L+
Sbjct: 228 NLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQ 287

Query: 678 GKPLSEAIHLLQMAGETVTLKIKKQTDAQSASSPKKFPISSHLSDL 723
                EA+  L+   + V LK+ K             P S HL+D+
Sbjct: 288 DVRHEEAVASLKNTSDMVYLKVAK-------------PGSLHLNDM 320



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 38/116 (32%), Positives = 55/116 (47%), Gaps = 2/116 (1%)

Query: 20  ESPYTKSASQTKPPDGALAVRRQSIPEE-FKGSTVVELMKKEGTTLGLTVSGGIDKDGKP 78
           ES  +  A    PP     + R  + EE F       ++ K  T LG  + GG D +G  
Sbjct: 351 ESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGI- 409

Query: 79  RVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEY 134
            VS +  GG A  S +L  GD I +VNG+NL    H++  + LK  G+ V +  +Y
Sbjct: 410 FVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQY 465



 Score = 39.7 bits (91), Expect = 0.015
 Identities = 27/87 (31%), Positives = 41/87 (47%), Gaps = 3/87 (3%)

Query: 949  ELHKVTLYKDSDMEDFGFSVADGLLEKGVYVKNIRPAGPGDLGG-LKPYDRLLQVNHVRT 1007
            E  K+ L+K S     GF++  G   +G++V  I   GP DL G L+  DR+L VN V  
Sbjct: 383  EPRKIILHKGST--GLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNL 440

Query: 1008 RDFDCCLVVPLIAESGNKLDLVISRNP 1034
            R+         +  +G  + +V    P
Sbjct: 441  RNATHEQAAAALKRAGQSVTIVAQYRP 467


>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
          Length = 904

 Score = 94.4 bits (233), Expect = 5e-19
 Identities = 96/440 (21%), Positives = 181/440 (41%), Gaps = 52/440 (11%)

Query: 138 PVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDR-NKSRPVVITCVRPGGPADREGT 196
           P  V G+   +   E+TL +  +  GF I GG  +        + IT +  GG A ++G 
Sbjct: 210 PTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGR 269

Query: 197 IKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASGPLLVEVA 256
           ++  D +L V+ + +   TH++A+  LK+ G    L ++    V + +       L++  
Sbjct: 270 LRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIK---LIKGP 326

Query: 257 KTPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAE 316
           K  G S+   +          I + KI     A + G L +GD +L+++   +E  T  E
Sbjct: 327 KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEE 386

Query: 317 ATQFLANTTDQVKLEILPHHQTRLALKGPDHAALVSSSFSPTSMSAYSLSSLNMGTLPRS 376
           A   L NT+D V L++               +  ++  ++P  ++  S   ++    P S
Sbjct: 387 AVTALKNTSDFVYLKV-----------AKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSS 435

Query: 377 LYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQ 436
               +P               +  S  S  V L    +  E  +VVL     TG G  + 
Sbjct: 436 FLGQTPAS------------PARYSPVSKAV-LGDDEITREPRKVVLHRGS-TGLGFNIV 481

Query: 437 GSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSS 496
           G             IS+I A  PA+  G L+ GDR++++N +    ++ E+A+  L+++ 
Sbjct: 482 GGEDGEGI-----FISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAG 536

Query: 497 ITSKVTLEIEF-------------DVAESVIP---SSGTFHVKLPKKHNVELGITISSPS 540
               VT+  ++             D+ E ++    SSG+  ++  +K ++ +        
Sbjct: 537 --QAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDK 594

Query: 541 SRKPGDPLVISDIKKGSVAH 560
           ++  G P    + K G + H
Sbjct: 595 TKDSGLPSQGLNFKFGDILH 614



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 87/337 (25%), Positives = 149/337 (44%), Gaps = 63/337 (18%)

Query: 451 ISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVA 510
           I+ I     A + G L++ D ++ +N +   D T  +A + L+++    ++ ++    V+
Sbjct: 255 ITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVS 314

Query: 511 ESVIPSSGTFHVKLPKKHNVELGITISSPSSRK--PGD-PLVISDIKKGSVAHRTGTLEL 567
           E ++       +K PK     LG +I+     +  PGD  + ++ I +G  AH+ G L++
Sbjct: 315 EKIMEIK---LIKGPKG----LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQI 367

Query: 568 GDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRK-------------DEDNSDEQ-- 612
           GDKLLA++N+ L+  + E+AV  L+   D V LK+ K             D  NS  Q  
Sbjct: 368 GDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPV 427

Query: 613 ---------------------ESSGAII---------YTVELKRYGGPLGITISGTEEPF 642
                                  S A++           V L R    LG  I G E+  
Sbjct: 428 DNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDG- 486

Query: 643 DPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQ 702
           + I IS +  GG A+ +G +  GDRI+++NS  L+     +A   L+ AG+ VT+  + +
Sbjct: 487 EGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYR 546

Query: 703 TDAQSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKL 739
            +  S    K       + DL +   +SS +   G L
Sbjct: 547 PEEYSRFEAK-------IHDLREQMMNSSISSGSGSL 576



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 84/357 (23%), Positives = 143/357 (40%), Gaps = 60/357 (16%)

Query: 57  MKKEGTTLGLTVSGGIDK-----DGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAK 111
           +++  + LG +++GG D      D    ++ +  GG AA+  +L V D I  VN +++  
Sbjct: 227 LERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRD 286

Query: 112 FRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAH 171
             H + +  LK  G  V L V+   P        V  + +E+ L K     GF I GG  
Sbjct: 287 VTHSKAVEALKEAGSIVRLYVKRRKP--------VSEKIMEIKLIKGPKGLGFSIAGGVG 338

Query: 172 DDRNKS-RPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEA 230
           +        + +T +  GG A ++G ++ GD+LL+V+ + L   TH EA++ LK      
Sbjct: 339 NQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFV 398

Query: 231 ALLIEYDVSVM--------DSVATASGPLLVEVA------KTPGA--------------- 261
            L +    S+         D   ++S P+   V+      +TP +               
Sbjct: 399 YLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDD 458

Query: 262 --------------SLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGT 307
                         S G+        + + I I  I +   AD  G L  GD I+S++  
Sbjct: 459 EITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSV 518

Query: 308 SMEYCTLAEATQFLANTTDQVKL--EILPHHQTRLALKGPD-HAALVSSSFSPTSMS 361
            +   +  +A   L N    V +  +  P   +R   K  D    +++SS S  S S
Sbjct: 519 DLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGS 575



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 56/217 (25%), Positives = 107/217 (49%), Gaps = 33/217 (15%)

Query: 526 KKHNVELGITISSPSSRKP-GDP--LVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNC 582
           ++ N  LG +I+  +     GD   + I+ I  G  A + G L + D +L ++ + + + 
Sbjct: 228 ERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDV 287

Query: 583 SMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGP--LGITISG--- 637
           +   AV+ L++   +V+L +++ +  S++          +E+K   GP  LG +I+G   
Sbjct: 288 THSKAVEALKEAGSIVRLYVKRRKPVSEK---------IMEIKLIKGPKGLGFSIAGGVG 338

Query: 638 -TEEPFD-PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETV 695
               P D  I ++ + +GG A + G + IGD++LA+N+  L+     EA+  L+   + V
Sbjct: 339 NQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFV 398

Query: 696 TLKIKKQT-----------DAQSASSPKKFPISSHLS 721
            LK+ K T           D  ++SS    P+ +H+S
Sbjct: 399 YLKVAKPTSMYMNDGYAPPDITNSSSQ---PVDNHVS 432



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 26/79 (32%), Positives = 43/79 (54%), Gaps = 1/79 (1%)

Query: 56  LMKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHD 115
           ++ +  T LG  + GG D +G   +S +  GG A  S +L  GD I +VN ++L    H+
Sbjct: 468 VLHRGSTGLGFNIVGGEDGEGI-FISFILAGGPADLSGELRKGDRIISVNSVDLRAASHE 526

Query: 116 EIISLLKNVGERVVLEVEY 134
           +  + LKN G+ V +  +Y
Sbjct: 527 QAAAALKNAGQAVTIVAQY 545



 Score = 38.9 bits (89), Expect = 0.026
 Identities = 33/133 (24%), Positives = 56/133 (42%), Gaps = 11/133 (8%)

Query: 906  SSSRP---HYSQTTRSNTLPSDVGRKSVTLRKMKQEIKEIMSPTPVELHKVTLYKDSDME 962
            SSS+P   H S ++     P+   R S   + +  + +    P  V LH+ +        
Sbjct: 422  SSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGST------- 474

Query: 963  DFGFSVADGLLEKGVYVKNIRPAGPGDLGG-LKPYDRLLQVNHVRTRDFDCCLVVPLIAE 1021
              GF++  G   +G+++  I   GP DL G L+  DR++ VN V  R          +  
Sbjct: 475  GLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKN 534

Query: 1022 SGNKLDLVISRNP 1034
            +G  + +V    P
Sbjct: 535  AGQAVTIVAQYRP 547



 Score = 33.1 bits (74), Expect = 1.4
 Identities = 27/107 (25%), Positives = 49/107 (45%), Gaps = 9/107 (8%)

Query: 949  ELHKVTLYKDSDMEDFGFSVADGLL------EKGVYVKNIRPAGPGDLGG-LKPYDRLLQ 1001
            E  ++TL + +     GFS+A G        +  +++  I   G     G L+  D +L+
Sbjct: 221  EYEEITLERGNS--GLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILR 278

Query: 1002 VNHVRTRDFDCCLVVPLIAESGNKLDLVISRNPLASQKSIDQQSLPG 1048
            VN V  RD      V  + E+G+ + L + R    S+K ++ + + G
Sbjct: 279  VNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKG 325


>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
          Length = 926

 Score = 94.4 bits (233), Expect = 5e-19
 Identities = 96/440 (21%), Positives = 181/440 (41%), Gaps = 52/440 (11%)

Query: 138 PVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDR-NKSRPVVITCVRPGGPADREGT 196
           P  V G+   +   E+TL +  +  GF I GG  +        + IT +  GG A ++G 
Sbjct: 210 PTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGR 269

Query: 197 IKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASGPLLVEVA 256
           ++  D +L V+ + +   TH++A+  LK+ G    L ++    V + +       L++  
Sbjct: 270 LRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIK---LIKGP 326

Query: 257 KTPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAE 316
           K  G S+   +          I + KI     A + G L +GD +L+++   +E  T  E
Sbjct: 327 KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEE 386

Query: 317 ATQFLANTTDQVKLEILPHHQTRLALKGPDHAALVSSSFSPTSMSAYSLSSLNMGTLPRS 376
           A   L NT+D V L++               +  ++  ++P  ++  S   ++    P S
Sbjct: 387 AVTALKNTSDFVYLKV-----------AKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSS 435

Query: 377 LYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQ 436
               +P               +  S  S  V L    +  E  +VVL     TG G  + 
Sbjct: 436 FLGQTPAS------------PARYSPVSKAV-LGDDEITREPRKVVLHRGS-TGLGFNIV 481

Query: 437 GSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSS 496
           G             IS+I A  PA+  G L+ GDR++++N +    ++ E+A+  L+++ 
Sbjct: 482 GGEDGEGI-----FISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAG 536

Query: 497 ITSKVTLEIEF-------------DVAESVIP---SSGTFHVKLPKKHNVELGITISSPS 540
               VT+  ++             D+ E ++    SSG+  ++  +K ++ +        
Sbjct: 537 --QAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDK 594

Query: 541 SRKPGDPLVISDIKKGSVAH 560
           ++  G P    + K G + H
Sbjct: 595 TKDSGLPSQGLNFKFGDILH 614



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 87/337 (25%), Positives = 149/337 (44%), Gaps = 63/337 (18%)

Query: 451 ISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVA 510
           I+ I     A + G L++ D ++ +N +   D T  +A + L+++    ++ ++    V+
Sbjct: 255 ITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVS 314

Query: 511 ESVIPSSGTFHVKLPKKHNVELGITISSPSSRK--PGD-PLVISDIKKGSVAHRTGTLEL 567
           E ++       +K PK     LG +I+     +  PGD  + ++ I +G  AH+ G L++
Sbjct: 315 EKIMEIK---LIKGPKG----LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQI 367

Query: 568 GDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRK-------------DEDNSDEQ-- 612
           GDKLLA++N+ L+  + E+AV  L+   D V LK+ K             D  NS  Q  
Sbjct: 368 GDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPV 427

Query: 613 ---------------------ESSGAII---------YTVELKRYGGPLGITISGTEEPF 642
                                  S A++           V L R    LG  I G E+  
Sbjct: 428 DNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDG- 486

Query: 643 DPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQ 702
           + I IS +  GG A+ +G +  GDRI+++NS  L+     +A   L+ AG+ VT+  + +
Sbjct: 487 EGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYR 546

Query: 703 TDAQSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKL 739
            +  S    K       + DL +   +SS +   G L
Sbjct: 547 PEEYSRFEAK-------IHDLREQMMNSSISSGSGSL 576



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 84/357 (23%), Positives = 143/357 (40%), Gaps = 60/357 (16%)

Query: 57  MKKEGTTLGLTVSGGIDK-----DGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAK 111
           +++  + LG +++GG D      D    ++ +  GG AA+  +L V D I  VN +++  
Sbjct: 227 LERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRD 286

Query: 112 FRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAH 171
             H + +  LK  G  V L V+   P        V  + +E+ L K     GF I GG  
Sbjct: 287 VTHSKAVEALKEAGSIVRLYVKRRKP--------VSEKIMEIKLIKGPKGLGFSIAGGVG 338

Query: 172 DDRNKS-RPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEA 230
           +        + +T +  GG A ++G ++ GD+LL+V+ + L   TH EA++ LK      
Sbjct: 339 NQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFV 398

Query: 231 ALLIEYDVSVM--------DSVATASGPLLVEVA------KTPGA--------------- 261
            L +    S+         D   ++S P+   V+      +TP +               
Sbjct: 399 YLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDD 458

Query: 262 --------------SLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGT 307
                         S G+        + + I I  I +   AD  G L  GD I+S++  
Sbjct: 459 EITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSV 518

Query: 308 SMEYCTLAEATQFLANTTDQVKL--EILPHHQTRLALKGPD-HAALVSSSFSPTSMS 361
            +   +  +A   L N    V +  +  P   +R   K  D    +++SS S  S S
Sbjct: 519 DLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGS 575



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 56/217 (25%), Positives = 107/217 (49%), Gaps = 33/217 (15%)

Query: 526 KKHNVELGITISSPSSRKP-GDP--LVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNC 582
           ++ N  LG +I+  +     GD   + I+ I  G  A + G L + D +L ++ + + + 
Sbjct: 228 ERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDV 287

Query: 583 SMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGP--LGITISG--- 637
           +   AV+ L++   +V+L +++ +  S++          +E+K   GP  LG +I+G   
Sbjct: 288 THSKAVEALKEAGSIVRLYVKRRKPVSEK---------IMEIKLIKGPKGLGFSIAGGVG 338

Query: 638 -TEEPFD-PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETV 695
               P D  I ++ + +GG A + G + IGD++LA+N+  L+     EA+  L+   + V
Sbjct: 339 NQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFV 398

Query: 696 TLKIKKQT-----------DAQSASSPKKFPISSHLS 721
            LK+ K T           D  ++SS    P+ +H+S
Sbjct: 399 YLKVAKPTSMYMNDGYAPPDITNSSSQ---PVDNHVS 432



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 26/79 (32%), Positives = 43/79 (54%), Gaps = 1/79 (1%)

Query: 56  LMKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHD 115
           ++ +  T LG  + GG D +G   +S +  GG A  S +L  GD I +VN ++L    H+
Sbjct: 468 VLHRGSTGLGFNIVGGEDGEGI-FISFILAGGPADLSGELRKGDRIISVNSVDLRAASHE 526

Query: 116 EIISLLKNVGERVVLEVEY 134
           +  + LKN G+ V +  +Y
Sbjct: 527 QAAAALKNAGQAVTIVAQY 545



 Score = 38.9 bits (89), Expect = 0.026
 Identities = 33/133 (24%), Positives = 56/133 (42%), Gaps = 11/133 (8%)

Query: 906  SSSRP---HYSQTTRSNTLPSDVGRKSVTLRKMKQEIKEIMSPTPVELHKVTLYKDSDME 962
            SSS+P   H S ++     P+   R S   + +  + +    P  V LH+ +        
Sbjct: 422  SSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGST------- 474

Query: 963  DFGFSVADGLLEKGVYVKNIRPAGPGDLGG-LKPYDRLLQVNHVRTRDFDCCLVVPLIAE 1021
              GF++  G   +G+++  I   GP DL G L+  DR++ VN V  R          +  
Sbjct: 475  GLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKN 534

Query: 1022 SGNKLDLVISRNP 1034
            +G  + +V    P
Sbjct: 535  AGQAVTIVAQYRP 547



 Score = 33.1 bits (74), Expect = 1.4
 Identities = 27/107 (25%), Positives = 49/107 (45%), Gaps = 9/107 (8%)

Query: 949  ELHKVTLYKDSDMEDFGFSVADGLL------EKGVYVKNIRPAGPGDLGG-LKPYDRLLQ 1001
            E  ++TL + +     GFS+A G        +  +++  I   G     G L+  D +L+
Sbjct: 221  EYEEITLERGNS--GLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILR 278

Query: 1002 VNHVRTRDFDCCLVVPLIAESGNKLDLVISRNPLASQKSIDQQSLPG 1048
            VN V  RD      V  + E+G+ + L + R    S+K ++ + + G
Sbjct: 279  VNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKG 325


>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
           sapiens]
          Length = 721

 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 92/374 (24%), Positives = 159/374 (42%), Gaps = 32/374 (8%)

Query: 128 VVLEVEYELPPVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRP-VVITCVR 186
           V++  +    P  V G+       E+TL +  +  GF I GG  +      P + IT + 
Sbjct: 38  VIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKII 97

Query: 187 PGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVAT 246
           PGG A ++G ++  D +L V+ + +   TH+ A+  LK+ G    L +       + V  
Sbjct: 98  PGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVME 157

Query: 247 ASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDG 306
                L++  K  G S+   +          I + KI     A + G L +GD IL+++ 
Sbjct: 158 IK---LIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNS 214

Query: 307 TSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLA--LKGPDHAALVSSSFSPTSMSAYS 364
             +E     +A   L NT D V L++       L+     PD    +++S+S    +  S
Sbjct: 215 VGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPD----ITTSYSQHLDNEIS 270

Query: 365 LSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQVVHTETTEVVLT 424
            SS      P ++  TSPR    R     KD             L  + +  E   +V+ 
Sbjct: 271 HSSYLGTDYPTAMTPTSPR----RYSPVAKDL------------LGEEDIPREPRRIVIH 314

Query: 425 ADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDST 484
               TG G  + G             IS+I A  PA+  G L+ GD+++++NG+   +++
Sbjct: 315 RGS-TGLGFNIVGGEDGEGIF-----ISFILAGGPADLSGELRKGDQILSVNGVDLRNAS 368

Query: 485 FEEASQLLRDSSIT 498
            E+A+  L+++  T
Sbjct: 369 HEQAAIALKNAGQT 382



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 83/353 (23%), Positives = 149/353 (42%), Gaps = 65/353 (18%)

Query: 429 TGFGIQLQGSVFATETLSSPPL-ISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEE 487
           +G G  + G          P + I+ I     A + G L++ D ++ +N +   + T   
Sbjct: 70  SGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSA 129

Query: 488 ASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITISSPSSRK--PG 545
           A + L+++    ++ +      AE V+       +K PK     LG +I+     +  PG
Sbjct: 130 AVEALKEAGSIVRLYVMRRKPPAEKVMEIK---LIKGPKG----LGFSIAGGVGNQHIPG 182

Query: 546 D-PLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRK 604
           D  + ++ I +G  AH+ G L++GDK+LA++++ L++   EDAV  L+   D+V LK+ K
Sbjct: 183 DNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAK 242

Query: 605 DED------------------NSDEQESSGAIIYT------------------------- 621
             +                  + D + S  + + T                         
Sbjct: 243 PSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEE 302

Query: 622 --------VELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINS 673
                   + + R    LG  I G E+  + I IS +  GG A+ +G +  GD+IL++N 
Sbjct: 303 DIPREPRRIVIHRGSTGLGFNIVGGEDG-EGIFISFILAGGPADLSGELRKGDQILSVNG 361

Query: 674 SSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQSASSPKKFPISSHL--SDLG 724
             L+     +A   L+ AG+TVT+  + + +  S    K   +   L  S LG
Sbjct: 362 VDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLG 414



 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 62/256 (24%), Positives = 105/256 (41%), Gaps = 65/256 (25%)

Query: 37  LAVRRQSIPEEFKGSTVVELMKKEGTT-LGLTVSGGIDK-----DGKPRVSNLRQGGIAA 90
           L V R+  P E     V+E+   +G   LG +++GG+       D    V+ + +GG A 
Sbjct: 143 LYVMRRKPPAE----KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAH 198

Query: 91  RSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEV----------EYELPPVS 140
           +  +L +GD I AVN + L    H++ ++ LKN  + V L+V           Y  P ++
Sbjct: 199 KDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDIT 258

Query: 141 VQGSSVIFRTVE----------------------------------------VTLHKEGN 160
              S  +   +                                         + +H+   
Sbjct: 259 TSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGST 318

Query: 161 TFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAM 220
             GF I GG   +      + I+ +  GGPAD  G ++ GD++LSV+G+ L   +H +A 
Sbjct: 319 GLGFNIVGGEDGEG-----IFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAA 373

Query: 221 SILKQCGQEAALLIEY 236
             LK  GQ   ++ +Y
Sbjct: 374 IALKNAGQTVTIIAQY 389



 Score = 63.9 bits (154), Expect = 8e-10
 Identities = 51/195 (26%), Positives = 98/195 (50%), Gaps = 19/195 (9%)

Query: 526 KKHNVELGITISSPSSRKP--GDPLV-ISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNC 582
           ++ N  LG +I+  +       DP + I+ I  G  A + G L + D +L ++ + +   
Sbjct: 66  ERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREV 125

Query: 583 SMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGP--LGITISG--- 637
           +   AV+ L++   +V+L + + +  +++          +E+K   GP  LG +I+G   
Sbjct: 126 THSAAVEALKEAGSIVRLYVMRRKPPAEK---------VMEIKLIKGPKGLGFSIAGGVG 176

Query: 638 -TEEPFD-PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETV 695
               P D  I ++ + +GG A + G + IGD+ILA+NS  L+     +A+  L+   + V
Sbjct: 177 NQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVV 236

Query: 696 TLKIKKQTDAQSASS 710
            LK+ K ++A  + S
Sbjct: 237 YLKVAKPSNAYLSDS 251



 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 27/80 (33%), Positives = 44/80 (55%), Gaps = 1/80 (1%)

Query: 56  LMKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHD 115
           ++ +  T LG  + GG D +G   +S +  GG A  S +L  GD I +VNG++L    H+
Sbjct: 312 VIHRGSTGLGFNIVGGEDGEGI-FISFILAGGPADLSGELRKGDQILSVNGVDLRNASHE 370

Query: 116 EIISLLKNVGERVVLEVEYE 135
           +    LKN G+ V +  +Y+
Sbjct: 371 QAAIALKNAGQTVTIIAQYK 390



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 88/424 (20%), Positives = 143/424 (33%), Gaps = 95/424 (22%)

Query: 57  MKKEGTTLGLTVSGGIDK-----DGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAK 111
           +++  + LG +++GG D      D    ++ +  GG AA+  +L V D I  VN +++ +
Sbjct: 65  LERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVRE 124

Query: 112 FRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKEGNTFGF------- 164
             H   +  LK  G  V L V    PP          + +E+ L K     GF       
Sbjct: 125 VTHSAAVEALKEAGSIVRLYVMRRKPPAE--------KVMEIKLIKGPKGLGFSIAGGVG 176

Query: 165 --------------VIRGGA-HDDRNKSRPVVITCVRPGGPAD--REGTI---------- 197
                         +I GGA H D        I  V   G  D   E  +          
Sbjct: 177 NQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVV 236

Query: 198 -----KPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASGPLL 252
                KP +  LS D       T + +  +  +    + L  +Y  ++  +      P+ 
Sbjct: 237 YLKVAKPSNAYLS-DSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVA 295

Query: 253 VE------VAKTPG------ASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDH 300
            +      + + P        S G+        + + I I  I +   AD  G L  GD 
Sbjct: 296 KDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQ 355

Query: 301 ILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHAALVSSSFSPTSM 360
           ILS++G                     V L    H Q  +ALK       + + + P   
Sbjct: 356 ILSVNG---------------------VDLRNASHEQAAIALKNAGQTVTIIAQYKPEEY 394

Query: 361 SAY---------SLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAG 411
           S +          L + ++G+   SL S   RG  +R        K    L+ +     G
Sbjct: 395 SRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFG 454

Query: 412 QVVH 415
            V+H
Sbjct: 455 DVLH 458



 Score = 35.0 bits (79), Expect = 0.38
 Identities = 22/89 (24%), Positives = 42/89 (47%), Gaps = 3/89 (3%)

Query: 947  PVELHKVTLYKDSDMEDFGFSVADGLLEKGVYVKNIRPAGPGDLGG-LKPYDRLLQVNHV 1005
            P E  ++ +++ S     GF++  G   +G+++  I   GP DL G L+  D++L VN V
Sbjct: 305  PREPRRIVIHRGST--GLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGV 362

Query: 1006 RTRDFDCCLVVPLIAESGNKLDLVISRNP 1034
              R+         +  +G  + ++    P
Sbjct: 363  DLRNASHEQAAIALKNAGQTVTIIAQYKP 391


>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
           sapiens]
          Length = 767

 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 93/368 (25%), Positives = 157/368 (42%), Gaps = 35/368 (9%)

Query: 134 YELPPVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRP-VVITCVRPGGPAD 192
           YEL    V G+       E+TL +  +  GF I GG  +      P + IT + PGG A 
Sbjct: 93  YEL---QVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAA 149

Query: 193 REGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASGPLL 252
           ++G ++  D +L V+ + +   TH+ A+  LK+ G    L +       + V       L
Sbjct: 150 QDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIK---L 206

Query: 253 VEVAKTPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYC 312
           ++  K  G S+   +          I + KI     A + G L +GD IL+++   +E  
Sbjct: 207 IKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDV 266

Query: 313 TLAEATQFLANTTDQVKLEILPHHQTRLA--LKGPDHAALVSSSFSPTSMSAYSLSSLNM 370
              +A   L NT D V L++       L+     PD    +++S+S    +  S SS   
Sbjct: 267 MHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPD----ITTSYSQHLDNEISHSSYLG 322

Query: 371 GTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQVVHTETTEVVLTADPVTG 430
              P ++  TSPR    R     KD             L  + +  E   +V+     TG
Sbjct: 323 TDYPTAMTPTSPR----RYSPVAKDL------------LGEEDIPREPRRIVIHRGS-TG 365

Query: 431 FGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQ 490
            G  + G             IS+I A  PA+  G L+ GD+++++NG+   +++ E+A+ 
Sbjct: 366 LGFNIVGGEDGEGIF-----ISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAI 420

Query: 491 LLRDSSIT 498
            L+++  T
Sbjct: 421 ALKNAGQT 428



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 83/353 (23%), Positives = 149/353 (42%), Gaps = 65/353 (18%)

Query: 429 TGFGIQLQGSVFATETLSSPPL-ISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEE 487
           +G G  + G          P + I+ I     A + G L++ D ++ +N +   + T   
Sbjct: 116 SGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSA 175

Query: 488 ASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITISSPSSRK--PG 545
           A + L+++    ++ +      AE V+       +K PK     LG +I+     +  PG
Sbjct: 176 AVEALKEAGSIVRLYVMRRKPPAEKVMEIK---LIKGPKG----LGFSIAGGVGNQHIPG 228

Query: 546 D-PLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRK 604
           D  + ++ I +G  AH+ G L++GDK+LA++++ L++   EDAV  L+   D+V LK+ K
Sbjct: 229 DNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAK 288

Query: 605 DED------------------NSDEQESSGAIIYT------------------------- 621
             +                  + D + S  + + T                         
Sbjct: 289 PSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEE 348

Query: 622 --------VELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINS 673
                   + + R    LG  I G E+  + I IS +  GG A+ +G +  GD+IL++N 
Sbjct: 349 DIPREPRRIVIHRGSTGLGFNIVGGEDG-EGIFISFILAGGPADLSGELRKGDQILSVNG 407

Query: 674 SSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQSASSPKKFPISSHL--SDLG 724
             L+     +A   L+ AG+TVT+  + + +  S    K   +   L  S LG
Sbjct: 408 VDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLG 460



 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 62/256 (24%), Positives = 105/256 (41%), Gaps = 65/256 (25%)

Query: 37  LAVRRQSIPEEFKGSTVVELMKKEGTT-LGLTVSGGIDK-----DGKPRVSNLRQGGIAA 90
           L V R+  P E     V+E+   +G   LG +++GG+       D    V+ + +GG A 
Sbjct: 189 LYVMRRKPPAE----KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAH 244

Query: 91  RSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEV----------EYELPPVS 140
           +  +L +GD I AVN + L    H++ ++ LKN  + V L+V           Y  P ++
Sbjct: 245 KDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDIT 304

Query: 141 VQGSSVIFRTVE----------------------------------------VTLHKEGN 160
              S  +   +                                         + +H+   
Sbjct: 305 TSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGST 364

Query: 161 TFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAM 220
             GF I GG   +      + I+ +  GGPAD  G ++ GD++LSV+G+ L   +H +A 
Sbjct: 365 GLGFNIVGGEDGEG-----IFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAA 419

Query: 221 SILKQCGQEAALLIEY 236
             LK  GQ   ++ +Y
Sbjct: 420 IALKNAGQTVTIIAQY 435



 Score = 63.9 bits (154), Expect = 8e-10
 Identities = 51/195 (26%), Positives = 98/195 (50%), Gaps = 19/195 (9%)

Query: 526 KKHNVELGITISSPSSRKP--GDPLV-ISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNC 582
           ++ N  LG +I+  +       DP + I+ I  G  A + G L + D +L ++ + +   
Sbjct: 112 ERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREV 171

Query: 583 SMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGP--LGITISG--- 637
           +   AV+ L++   +V+L + + +  +++          +E+K   GP  LG +I+G   
Sbjct: 172 THSAAVEALKEAGSIVRLYVMRRKPPAEK---------VMEIKLIKGPKGLGFSIAGGVG 222

Query: 638 -TEEPFD-PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETV 695
               P D  I ++ + +GG A + G + IGD+ILA+NS  L+     +A+  L+   + V
Sbjct: 223 NQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVV 282

Query: 696 TLKIKKQTDAQSASS 710
            LK+ K ++A  + S
Sbjct: 283 YLKVAKPSNAYLSDS 297



 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 27/80 (33%), Positives = 44/80 (55%), Gaps = 1/80 (1%)

Query: 56  LMKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHD 115
           ++ +  T LG  + GG D +G   +S +  GG A  S +L  GD I +VNG++L    H+
Sbjct: 358 VIHRGSTGLGFNIVGGEDGEGI-FISFILAGGPADLSGELRKGDQILSVNGVDLRNASHE 416

Query: 116 EIISLLKNVGERVVLEVEYE 135
           +    LKN G+ V +  +Y+
Sbjct: 417 QAAIALKNAGQTVTIIAQYK 436



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 88/424 (20%), Positives = 143/424 (33%), Gaps = 95/424 (22%)

Query: 57  MKKEGTTLGLTVSGGIDK-----DGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAK 111
           +++  + LG +++GG D      D    ++ +  GG AA+  +L V D I  VN +++ +
Sbjct: 111 LERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVRE 170

Query: 112 FRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKEGNTFGF------- 164
             H   +  LK  G  V L V    PP          + +E+ L K     GF       
Sbjct: 171 VTHSAAVEALKEAGSIVRLYVMRRKPPAE--------KVMEIKLIKGPKGLGFSIAGGVG 222

Query: 165 --------------VIRGGA-HDDRNKSRPVVITCVRPGGPAD--REGTI---------- 197
                         +I GGA H D        I  V   G  D   E  +          
Sbjct: 223 NQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVV 282

Query: 198 -----KPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASGPLL 252
                KP +  LS D       T + +  +  +    + L  +Y  ++  +      P+ 
Sbjct: 283 YLKVAKPSNAYLS-DSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVA 341

Query: 253 VE------VAKTPG------ASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDH 300
            +      + + P        S G+        + + I I  I +   AD  G L  GD 
Sbjct: 342 KDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQ 401

Query: 301 ILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHAALVSSSFSPTSM 360
           ILS++G                     V L    H Q  +ALK       + + + P   
Sbjct: 402 ILSVNG---------------------VDLRNASHEQAAIALKNAGQTVTIIAQYKPEEY 440

Query: 361 SAY---------SLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAG 411
           S +          L + ++G+   SL S   RG  +R        K    L+ +     G
Sbjct: 441 SRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFG 500

Query: 412 QVVH 415
            V+H
Sbjct: 501 DVLH 504



 Score = 35.0 bits (79), Expect = 0.38
 Identities = 22/89 (24%), Positives = 42/89 (47%), Gaps = 3/89 (3%)

Query: 947  PVELHKVTLYKDSDMEDFGFSVADGLLEKGVYVKNIRPAGPGDLGG-LKPYDRLLQVNHV 1005
            P E  ++ +++ S     GF++  G   +G+++  I   GP DL G L+  D++L VN V
Sbjct: 351  PREPRRIVIHRGST--GLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGV 408

Query: 1006 RTRDFDCCLVVPLIAESGNKLDLVISRNP 1034
              R+         +  +G  + ++    P
Sbjct: 409  DLRNASHEQAAIALKNAGQTVTIIAQYKP 437


>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
            containing 1 isoform a [Homo sapiens]
          Length = 1287

 Score = 87.0 bits (214), Expect = 8e-17
 Identities = 172/850 (20%), Positives = 285/850 (33%), Gaps = 209/850 (24%)

Query: 17   TKDESPYTKSASQTKPPDGALAVRRQSI---------PEEFKGSTVVELMKKEGTTLGLT 67
            T+D S          PP      R   +         P E KG  +   ++K     G T
Sbjct: 426  TEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFT 485

Query: 68   VSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNV--G 125
            V GG + D   ++ +L   G AA   +++ GD I +VN   +    H +++ + +++  G
Sbjct: 486  VVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIG 545

Query: 126  ERVVLEVEYELP-PVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITC 184
              V LE+    P P      +    T    L KE      ++ G    D           
Sbjct: 546  ASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEP----IIVNGQETYDS---------- 591

Query: 185  VRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSV 244
              P   + + G +               G   A   S        +       VS+  S+
Sbjct: 592  --PASHSSKTGKVN--------------GMKDARPSSPADVASNSSHGYPNDTVSLASSI 635

Query: 245  ATASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSI 304
            AT    + V + K P    G  +  S     Q     ++K    + RC  L  GD I+ +
Sbjct: 636  ATQPELITVHIVKGP-MGFGFTIADSPGGGGQ-----RVKQIVDSPRCRGLKEGDLIVEV 689

Query: 305  DGTSMEYCTLAEATQFLANTTDQVKLEIL------------PHHQT-------------- 338
            +  +++  T  +    L       ++ +L            P  Q               
Sbjct: 690  NKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSV 749

Query: 339  ----RLALKGPDHAALVSSSFSPTSMSAYSLSSLNMGTLP---------RSLYSTSPRGT 385
                 L    P H+  V   F P    A   +  +    P         RS+Y   P   
Sbjct: 750  SSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSP 809

Query: 386  MMRRRLKKKDFKSSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETL 445
                 L K + +  ++  S+  G      + E    +   +  TGFG ++ G     E  
Sbjct: 810  SPASGLSKGEREREIN--STNFGECPIPDYQEQDIFLWRKE--TGFGFRILGGNEPGE-- 863

Query: 446  SSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLL----RDSSITSKV 501
              P  I +I     A+  G L+ GD ++ ++G P    + +   QL+    +   +   V
Sbjct: 864  --PIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTV 921

Query: 502  TLEIEFDV--AESVIP--------------------------------SSGT-------- 519
              ++ F V   E+ +P                                SSG+        
Sbjct: 922  RRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGS 981

Query: 520  ---------------FHVKLPKKHNVELGITISSPSSRKPGD----------PLVISDIK 554
                           + V++ +  N   G  I S  SR              P  I  I 
Sbjct: 982  GGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRII 1041

Query: 555  KGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNSD---- 610
            +GS A R G L++GD++LA++   + N S  D V ++++  + V L+I   +++S+    
Sbjct: 1042 EGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLL 1101

Query: 611  -----------------------------EQESSGAI----------IYTVELKRYGGPL 631
                                         +QES               YTVEL+R     
Sbjct: 1102 TNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGF 1161

Query: 632  GITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMA 691
            G ++ G  E    + +  L + G AER G + IGD IL IN  + K    S AI L++  
Sbjct: 1162 GFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNG 1221

Query: 692  GETVTLKIKK 701
            G  V L +K+
Sbjct: 1222 GRRVRLFLKR 1231



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 78/384 (20%), Positives = 144/384 (37%), Gaps = 60/384 (15%)

Query: 278  IVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQ 337
            I I  I     AD  G L  GD ++ +DGT +   +     Q +     Q  + +    +
Sbjct: 865  IYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRK 924

Query: 338  TRLALKGPDHAALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFK 397
               A+   ++     +S   +S    SL+              +P+G+            
Sbjct: 925  VVFAVPKTENEVPSPASSHHSSNQPASLTE----------EKRTPQGSQNSLNTVSSGSG 974

Query: 398  SSLSLASSTVGLAGQV-VHTETTEVVLTADPVTGFGIQLQGSV--------FATETLSSP 448
            S+  + S   G +G V    +  +V +      GFG  +  SV        F    ++ P
Sbjct: 975  STSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMP 1034

Query: 449  PLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSIT---------- 498
              I  I   SPA+RCG L++GDR++A+NG    + +  +   L++++  T          
Sbjct: 1035 HKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDE 1094

Query: 499  -SKVTLEIEFDVAESVIPS-----SGT--------------FHVKLPKK------HNVEL 532
             S  TL    +   ++  +      GT              F  K P+       + VEL
Sbjct: 1095 SSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVEL 1154

Query: 533  -----GITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDA 587
                 G   S    R+    L +  + +   A R G + +GD++L I+     N     A
Sbjct: 1155 ERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRA 1214

Query: 588  VQILQQCEDLVKLKIRKDEDNSDE 611
            +++++     V+L +++ + +  E
Sbjct: 1215 IELIKNGGRRVRLFLKRGDGSVPE 1238



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 88/423 (20%), Positives = 158/423 (37%), Gaps = 65/423 (15%)

Query: 632  GITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMA 691
            G  I G  EP +PI I  +   G A+  G +  GD ++ ++ + + GK     + L+Q A
Sbjct: 852  GFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQA 911

Query: 692  GE----TVTLKIKKQTDAQSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDMYPSTV 747
             +     +T++ K         +    P SSH S           + +P  L++   +  
Sbjct: 912  AKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHS-----------SNQPASLTEEKRTPQ 960

Query: 748  PSVDS--AVDSWDGSAIDTSYGTQGTSFQASGYNFNTYDWRSPKQRGSLSPVTKPRSQTY 805
             S +S   V S  GS      G  G S   S      YD    +            S + 
Sbjct: 961  GSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTV-VQPYDVEIRRGENEGFGFVIVSSVSR 1019

Query: 806  PDVGLSYEDWDRSTASGFAGAADSAETEQ------EENFWSQALEDLETCGQSGILRELE 859
            P+ G ++ +   +         + +  ++       +   +     +     S I+  ++
Sbjct: 1020 PEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIK 1079

Query: 860  EKADRRVSLR--------NMTLLATIMSGSTMSLNHEAPTPRSQLGRQASFQERSSSRPH 911
            E A   V+LR        N TLL      +T++  H   TP SQ G              
Sbjct: 1080 E-AGNTVTLRIIPGDESSNATLLTNAEKIATITTTH---TP-SQQG-------------- 1120

Query: 912  YSQTTRSNTLPSDVGRKSVTLRKMKQEIKEIMSPTPVELHKVTLYKDSDMEDFGFSVADG 971
             +Q TR+ T P          ++ + E K   +    + + V L + +  + FGFS+  G
Sbjct: 1121 -TQETRNTTKPK---------QESQFEFKAPQATQEQDFYTVELERGA--KGFGFSLRGG 1168

Query: 972  L-LEKGVYVKNIRPAGPGD-LGGLKPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLV 1029
                  +YV  +   GP +  G ++  D +L++N   T++      + LI   G ++ L 
Sbjct: 1169 REYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLF 1228

Query: 1030 ISR 1032
            + R
Sbjct: 1229 LKR 1231



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 33/127 (25%), Positives = 52/127 (40%), Gaps = 12/127 (9%)

Query: 16   LTKDESPYTKSASQTKPPDGALAVRRQSIPE-----EFKGSTVVEL-------MKKEGTT 63
            LT  E   T + + T    G    R  + P+     EFK     +        +++    
Sbjct: 1101 LTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKG 1160

Query: 64   LGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKN 123
             G ++ GG + +    V  L + G A R  ++ +GD I  +NG      +H   I L+KN
Sbjct: 1161 FGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKN 1220

Query: 124  VGERVVL 130
             G RV L
Sbjct: 1221 GGRRVRL 1227


>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
            containing 1 isoform b [Homo sapiens]
          Length = 1256

 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 172/851 (20%), Positives = 285/851 (33%), Gaps = 210/851 (24%)

Query: 17   TKDESPYTKSASQTKPPDGALAVRRQSI---------PEEFKGSTVVELMKKEGTTLGLT 67
            T+D S          PP      R   +         P E KG  +   ++K     G T
Sbjct: 426  TEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFT 485

Query: 68   VSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNV--G 125
            V GG + D   ++ +L   G AA   +++ GD I +VN   +    H +++ + +++  G
Sbjct: 486  VVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIG 545

Query: 126  ERVVLEVEYELP-PVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITC 184
              V LE+    P P      +    T    L KE      ++ G    D           
Sbjct: 546  ASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEP----IIVNGQETYDS---------- 591

Query: 185  VRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSV 244
              P   + + G +               G   A   S        +       VS+  S+
Sbjct: 592  --PASHSSKTGKVN--------------GMKDARPSSPADVASNSSHGYPNDTVSLASSI 635

Query: 245  ATASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSI 304
            AT    + V + K P    G  +  S     Q     ++K    + RC  L  GD I+ +
Sbjct: 636  ATQPELITVHIVKGP-MGFGFTIADSPGGGGQ-----RVKQIVDSPRCRGLKEGDLIVEV 689

Query: 305  DGTSMEYCTLAEATQFLANTTDQVKLEIL------------PHHQT-------------- 338
            +  +++  T  +    L       ++ +L            P  Q               
Sbjct: 690  NKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSV 749

Query: 339  ----RLALKGPDHAALVSSSFSPTSMSAYSLSSLNMGTLP---------RSLYSTSPRGT 385
                 L    P H+  V   F P    A   +  +    P         RS+Y   P   
Sbjct: 750  SSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSP 809

Query: 386  MMRRRLKKKDFKSSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETL 445
                 L K + +  ++  S+  G      + E    +   +  TGFG ++ G     E  
Sbjct: 810  SPASGLSKGEREREIN--STNFGECPIPDYQEQDIFLWRKE--TGFGFRILGGNEPGE-- 863

Query: 446  SSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLL----RDSSITSKV 501
              P  I +I     A+  G L+ GD ++ ++G P    + +   QL+    +   +   V
Sbjct: 864  --PIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTV 921

Query: 502  TLEIEFDV--AESVIP--------------------------------SSGT-------- 519
              ++ F V   E+ +P                                SSG+        
Sbjct: 922  RRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGS 981

Query: 520  ---------------FHVKLPKKHNVELGITISSPSSRKPGD-----------PLVISDI 553
                           + V++ +  N   G  I S  SR               P  I  I
Sbjct: 982  GGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGRI 1041

Query: 554  KKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNSD--- 610
             +GS A R G L++GD++LA++   + N S  D V ++++  + V L+I   +++S+   
Sbjct: 1042 IEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATL 1101

Query: 611  ------------------------------EQESSGAI----------IYTVELKRYGGP 630
                                          +QES               YTVEL+R    
Sbjct: 1102 LTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKG 1161

Query: 631  LGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQM 690
             G ++ G  E    + +  L + G AER G + IGD IL IN  + K    S AI L++ 
Sbjct: 1162 FGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKN 1221

Query: 691  AGETVTLKIKK 701
             G  V L +K+
Sbjct: 1222 GGRRVRLFLKR 1232



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 89/414 (21%), Positives = 153/414 (36%), Gaps = 46/414 (11%)

Query: 632  GITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMA 691
            G  I G  EP +PI I  +   G A+  G +  GD ++ ++ + + GK     + L+Q A
Sbjct: 852  GFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQA 911

Query: 692  GE----TVTLKIKKQTDAQSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDMYPSTV 747
             +     +T++ K         +    P SSH S           + +P  L++   +  
Sbjct: 912  AKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHS-----------SNQPASLTEEKRTPQ 960

Query: 748  PSVDS--AVDSWDGSAIDTSYGTQGTSFQASGYNFNTYDWRSPKQRGSLSPVTKPRSQTY 805
             S +S   V S  GS      G  G S   S      YD    +            S + 
Sbjct: 961  GSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTV-VQPYDVEIRRGENEGFGFVIVSSVSR 1019

Query: 806  PDVGLSYEDWDRSTASGFAGAADSAETEQEENFWSQALEDLETCGQSGILRELEEKADRR 865
            P+ G +           FAG A  A   +       +  D   CG+         K   R
Sbjct: 1020 PEAGTT-----------FAGNACVAMPHKIGRIIEGSPAD--RCGKL--------KVGDR 1058

Query: 866  VSLRNMTLLATIMSGSTMSLNHEA---PTPRSQLGRQASFQERSSSRPHYSQTTRSNTLP 922
            +   N   +        ++L  EA    T R   G ++S     ++    +  T ++T  
Sbjct: 1059 ILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPS 1118

Query: 923  SDVGRKSVTLRKMKQEIK-EIMSPTPV-ELHKVTLYKDSDMEDFGFSVADGL-LEKGVYV 979
                +++    K KQE + E  +P    E    T+  +   + FGFS+  G      +YV
Sbjct: 1119 QQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYV 1178

Query: 980  KNIRPAGPGD-LGGLKPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISR 1032
              +   GP +  G ++  D +L++N   T++      + LI   G ++ L + R
Sbjct: 1179 LRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKR 1232



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 33/127 (25%), Positives = 52/127 (40%), Gaps = 12/127 (9%)

Query: 16   LTKDESPYTKSASQTKPPDGALAVRRQSIPE-----EFKGSTVVEL-------MKKEGTT 63
            LT  E   T + + T    G    R  + P+     EFK     +        +++    
Sbjct: 1102 LTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKG 1161

Query: 64   LGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKN 123
             G ++ GG + +    V  L + G A R  ++ +GD I  +NG      +H   I L+KN
Sbjct: 1162 FGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKN 1221

Query: 124  VGERVVL 130
             G RV L
Sbjct: 1222 GGRRVRL 1228


>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
            containing 1 isoform c [Homo sapiens]
          Length = 1462

 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 172/822 (20%), Positives = 286/822 (34%), Gaps = 181/822 (22%)

Query: 17   TKDESPYTKSASQTKPPDGALAVRRQSI---------PEEFKGSTVVELMKKEGTTLGLT 67
            T+D S          PP      R   +         P E KG  +   ++K     G T
Sbjct: 426  TEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFT 485

Query: 68   VSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNV--G 125
            V GG + D   ++ +L   G AA   +++ GD I +VN   +    H +++ + +++  G
Sbjct: 486  VVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIG 545

Query: 126  ERVVLEVEYELP-PVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITC 184
              V LE+    P P      +    T    L KE      ++ G    D           
Sbjct: 546  ASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEP----IIVNGQETYDS---------- 591

Query: 185  VRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSV 244
              P   + + G +               G   A   S        +       VS+  S+
Sbjct: 592  --PASHSSKTGKVN--------------GMKDARPSSPADVASNSSHGYPNDTVSLASSI 635

Query: 245  ATASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSI 304
            AT    + V + K P    G  +  S     Q     ++K    + RC  L  GD I+ +
Sbjct: 636  ATQPELITVHIVKGP-MGFGFTIADSPGGGGQ-----RVKQIVDSPRCRGLKEGDLIVEV 689

Query: 305  DGTSMEYCTLAEATQFLANTTDQVKLEILPHHQ-TRLALKGPDHAALV------SSSFSP 357
            +  +++  T  +    L       ++ +L       +  K P    L       SS  S 
Sbjct: 690  NKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSV 749

Query: 358  TSMSAYSLSSLNMGT--LPR--SLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQV 413
            +S  +   +S +  T  LP      + +P  T    + K   FK     A S      ++
Sbjct: 750  SSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKI---WAQSRSMYENRL 806

Query: 414  VHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVM 473
               +  ++ L     TGFG ++ G     E    P  I +I     A+  G L+ GD ++
Sbjct: 807  PDYQEQDIFLWRKE-TGFGFRILGGNEPGE----PIYIGHIVPLGAADTDGRLRSGDELI 861

Query: 474  AINGIPTEDSTFEEASQLL----RDSSITSKVTLEIEFDV--AESVIP------------ 515
             ++G P    + +   QL+    +   +   V  ++ F V   E+ +P            
Sbjct: 862  CVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQP 921

Query: 516  --------------------SSGT-----------------------FHVKLPKKHNVEL 532
                                SSG+                       + V++ +  N   
Sbjct: 922  ASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGF 981

Query: 533  GITISSPSSRKPGD----------PLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNC 582
            G  I S  SR              P  I  I +GS A R G L++GD++LA++   + N 
Sbjct: 982  GFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNK 1041

Query: 583  SMEDAVQILQQCEDLVKLKIRKDEDNSD-------------------------------- 610
            S  D V ++++  + V L+I   +++S+                                
Sbjct: 1042 SHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTK 1101

Query: 611  -EQESSGAI----------IYTVELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERT 659
             +QES               YTVEL+R     G ++ G  E    + +  L + G AER 
Sbjct: 1102 PKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERC 1161

Query: 660  GAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKK 701
            G + IGD IL IN  + K    S AI L++  G  V L +K+
Sbjct: 1162 GKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKR 1203



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 79/388 (20%), Positives = 146/388 (37%), Gaps = 60/388 (15%)

Query: 278  IVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQ 337
            I I  I     AD  G L  GD ++ +DGT +   +     Q +     Q  + +    +
Sbjct: 837  IYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRK 896

Query: 338  TRLALKGPDHAALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFK 397
               A+   ++     +S   +S    SL+              +P+G+            
Sbjct: 897  VVFAVPKTENEVPSPASSHHSSNQPASLTE----------EKRTPQGSQNSLNTVSSGSG 946

Query: 398  SSLSLASSTVGLAGQV-VHTETTEVVLTADPVTGFGIQLQGSV--------FATETLSSP 448
            S+  + S   G +G V    +  +V +      GFG  +  SV        F    ++ P
Sbjct: 947  STSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMP 1006

Query: 449  PLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSIT---------- 498
              I  I   SPA+RCG L++GDR++A+NG    + +  +   L++++  T          
Sbjct: 1007 HKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDE 1066

Query: 499  -SKVTLEIEFDVAESVIPS-----SGT--------------FHVKLPKK------HNVEL 532
             S  TL    +   ++  +      GT              F  K P+       + VEL
Sbjct: 1067 SSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVEL 1126

Query: 533  -----GITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDA 587
                 G   S    R+    L +  + +   A R G + +GD++L I+     N     A
Sbjct: 1127 ERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRA 1186

Query: 588  VQILQQCEDLVKLKIRKDEDNSDEQESS 615
            +++++     V+L +++ + +  E + S
Sbjct: 1187 IELIKNGGRRVRLFLKRGDGSVPEYDPS 1214



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 55/227 (24%), Positives = 91/227 (40%), Gaps = 65/227 (28%)

Query: 79   RVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEV------ 132
            ++  + +G  A R  +L VGD I AVNG ++    H +I++L+K  G  V L +      
Sbjct: 1008 KIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDES 1067

Query: 133  -----------------------------------------EYELPPVSVQGSSVIFRTV 151
                                                     E++ P  + +     F TV
Sbjct: 1068 SNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQD---FYTV 1124

Query: 152  EVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRL 211
            E+    +G  FGF +RGG    R  +  + +  +   GPA+R G ++ GD +L ++G   
Sbjct: 1125 ELERGAKG--FGFSLRGG----REYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETT 1178

Query: 212  LGTTHAEAMSILKQCGQEAALLI--------EYDVSVMDSVATASGP 250
                H+ A+ ++K  G+   L +        EYD S  D    A+GP
Sbjct: 1179 KNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPS-SDRHGPATGP 1224



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 71/317 (22%), Positives = 120/317 (37%), Gaps = 72/317 (22%)

Query: 145  SVIFRTVEVTLHK-EGNTFGFVI--------RGGAHDDRNKSRPVVITCVRPGGPADREG 195
            S + +  +V + + E   FGFVI         G    +   + P  I  +  G PADR G
Sbjct: 963  STVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCG 1022

Query: 196  TIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAAL-LIEYDVSVMDSVATASGPLLVE 254
             +K GDR+L+V+G  +   +H++ ++++K+ G    L +I  D S   ++ T +  +   
Sbjct: 1023 KLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATI 1082

Query: 255  VA--------------------------KTPGAS----------------LGVALTTSMC 272
                                        K P A+                 G +L     
Sbjct: 1083 TTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGRE 1142

Query: 273  CNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKL-- 330
             N  + V+ ++     A+RCG + +GD IL I+G + +    + A + + N   +V+L  
Sbjct: 1143 YNMDLYVL-RLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFL 1201

Query: 331  --------EILPHHQTRLALKGPDHAALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSP 382
                    E  P         GP     V +   P      SL S    + P  L+ +SP
Sbjct: 1202 KRGDGSVPEYDPSSDRHGPATGPQGVPEVRA--GPDRRQHPSLES----SYPPDLHKSSP 1255

Query: 383  RGTMMRRRLKKKDFKSS 399
             G    +R   +D K S
Sbjct: 1256 HG---EKRAHARDPKGS 1269



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 88/423 (20%), Positives = 158/423 (37%), Gaps = 65/423 (15%)

Query: 632  GITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMA 691
            G  I G  EP +PI I  +   G A+  G +  GD ++ ++ + + GK     + L+Q A
Sbjct: 824  GFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQA 883

Query: 692  GE----TVTLKIKKQTDAQSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDMYPSTV 747
             +     +T++ K         +    P SSH S           + +P  L++   +  
Sbjct: 884  AKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHS-----------SNQPASLTEEKRTPQ 932

Query: 748  PSVDS--AVDSWDGSAIDTSYGTQGTSFQASGYNFNTYDWRSPKQRGSLSPVTKPRSQTY 805
             S +S   V S  GS      G  G S   S      YD    +            S + 
Sbjct: 933  GSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTV-VQPYDVEIRRGENEGFGFVIVSSVSR 991

Query: 806  PDVGLSYEDWDRSTASGFAGAADSAETEQ------EENFWSQALEDLETCGQSGILRELE 859
            P+ G ++ +   +         + +  ++       +   +     +     S I+  ++
Sbjct: 992  PEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIK 1051

Query: 860  EKADRRVSLR--------NMTLLATIMSGSTMSLNHEAPTPRSQLGRQASFQERSSSRPH 911
            E A   V+LR        N TLL      +T++  H   TP SQ G              
Sbjct: 1052 E-AGNTVTLRIIPGDESSNATLLTNAEKIATITTTH---TP-SQQG-------------- 1092

Query: 912  YSQTTRSNTLPSDVGRKSVTLRKMKQEIKEIMSPTPVELHKVTLYKDSDMEDFGFSVADG 971
             +Q TR+ T P          ++ + E K   +    + + V L + +  + FGFS+  G
Sbjct: 1093 -TQETRNTTKPK---------QESQFEFKAPQATQEQDFYTVELERGA--KGFGFSLRGG 1140

Query: 972  L-LEKGVYVKNIRPAGPGD-LGGLKPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLV 1029
                  +YV  +   GP +  G ++  D +L++N   T++      + LI   G ++ L 
Sbjct: 1141 REYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLF 1200

Query: 1030 ISR 1032
            + R
Sbjct: 1201 LKR 1203



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 33/127 (25%), Positives = 52/127 (40%), Gaps = 12/127 (9%)

Query: 16   LTKDESPYTKSASQTKPPDGALAVRRQSIPE-----EFKGSTVVEL-------MKKEGTT 63
            LT  E   T + + T    G    R  + P+     EFK     +        +++    
Sbjct: 1073 LTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKG 1132

Query: 64   LGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKN 123
             G ++ GG + +    V  L + G A R  ++ +GD I  +NG      +H   I L+KN
Sbjct: 1133 FGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKN 1192

Query: 124  VGERVVL 130
             G RV L
Sbjct: 1193 GGRRVRL 1199


>gi|45827729 scribble isoform b [Homo sapiens]
          Length = 1630

 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 87/319 (27%), Positives = 131/319 (41%), Gaps = 64/319 (20%)

Query: 64   LGLTVSGGIDK------DGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEI 117
            LG +++GG         D    VS + +GG A R+  L VGD + ++NG+++ + RHD  
Sbjct: 872  LGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHA 931

Query: 118  ISLLKNVGERVVLEVEYE----LPPVSVQGSSVIFRTV---------------------- 151
            +SLL      + L +E E    LPP  +  SS     V                      
Sbjct: 932  VSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSL 991

Query: 152  ------------EVTLHKEGNTFGFVIRGGA----HDDRNKSRPVVITCVRPGGPADREG 195
                        E+ L + G   G  I GG+    H    +   V I+ V P G A R G
Sbjct: 992  LAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG 1051

Query: 196  TIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASGPLLVEV 255
             ++ GDR+L+V+G  +   TH EA+S L +   E +LL+  D           G   + +
Sbjct: 1052 -LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRD-------PAPPGLRELCI 1103

Query: 256  AKTPGASLGVALT--------TSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGT 307
             K PG  LG+++                + I I K+     A R G L VG  +L ++  
Sbjct: 1104 QKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQ 1163

Query: 308  SMEYCTLAEATQFLANTTD 326
            S+   T  EA Q L +  D
Sbjct: 1164 SLLGLTHGEAVQLLRSVGD 1182



 Score = 84.0 bits (206), Expect = 7e-16
 Identities = 123/502 (24%), Positives = 188/502 (37%), Gaps = 94/502 (18%)

Query: 153  VTLHKEGNTFGFVIRGGAHDDRNKS--RPVVITCVRPGGPADREGTIKPGDRLLSVDGIR 210
            +T+ ++    G  I GG      K     + I+ V   GPA R G ++ GD+LL V+G+ 
Sbjct: 729  LTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVA 787

Query: 211  LLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASGPLLVEVAKTPGASLGVAL--- 267
            L G  H EA+  L+  G    + +  +  V    A    PL  E   +P    G  L   
Sbjct: 788  LQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLP 847

Query: 268  ----------------------------------TTSMCCNKQVIVIDKIKSASIADRCG 293
                                              +T        I + +I     A R G
Sbjct: 848  LLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAG 907

Query: 294  ALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEIL-----PHHQTRLALKGPDHA 348
             L VGD +LSI+G  +       A   L   +  + L +      P   + L    P  A
Sbjct: 908  TLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTA 967

Query: 349  ALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVG 408
            A+ ++S +  +     L SL    L  +L    P   +   RL +      LS+    VG
Sbjct: 968  AVATTSITTATPGVPGLPSLAPSLLAAALEGPYP---VEEIRLPRAGGPLGLSI----VG 1020

Query: 409  LAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQI 468
             +    H               FG+Q  G VF          IS +     A R G L++
Sbjct: 1021 GSDHSSHP--------------FGVQEPG-VF----------ISKVLPRGLAARSG-LRV 1054

Query: 469  GDRVMAINGIPTEDSTFEEA-SQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKK 527
            GDR++A+NG    D+T +EA S LLR         LE+   V     P  G   + + K 
Sbjct: 1055 GDRILAVNGQDVRDATHQEAVSALLRP-------CLELSLLVRRDPAP-PGLRELCIQKA 1106

Query: 528  HNVELGITISSPSSRKPGDP-------LVISDIKKGSVAHRTGTLELGDKLLAIDNIRLD 580
                LGI+I   +    G+P       + IS +     A R G L +G +LL ++   L 
Sbjct: 1107 PGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLL 1166

Query: 581  NCSMEDAVQILQQCEDLVKLKI 602
              +  +AVQ+L+   D + + +
Sbjct: 1167 GLTHGEAVQLLRSVGDTLTVLV 1188



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 128/540 (23%), Positives = 209/540 (38%), Gaps = 120/540 (22%)

Query: 278  IVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQ 337
            I I ++     A R G + VGD +L ++G +++     EA + L      V++ +     
Sbjct: 758  IFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVW---- 812

Query: 338  TRLALKGPDHAALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFK 397
             R  +  P++A  ++          YS      G L   L      G + +R +      
Sbjct: 813  -RERMVEPENAVTITPLRPEDD---YSPRERRGGGLRLPLLPPESPGPLRQRHVA----- 863

Query: 398  SSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEAD 457
                LA S  GL   +   + +      D     GI                 +S I   
Sbjct: 864  ---CLARSERGLGFSIAGGKGSTPYRAGDA----GI----------------FVSRIAEG 900

Query: 458  SPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVAESVIPSS 517
              A R G LQ+GDRV++ING+   ++  + A  LL  +S T  + LE E   A   +P S
Sbjct: 901  GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLERE---AGGPLPPS 957

Query: 518  GTFHVKLPKKHNVELGITISSPSSR--------------------------KPGDPL--- 548
               H   P        IT ++P                             + G PL   
Sbjct: 958  PLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLS 1017

Query: 549  -------------------VISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQ 589
                                IS +    +A R+G L +GD++LA++   + + + ++AV 
Sbjct: 1018 IVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVS 1076

Query: 590  -ILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISG-----TEEPFD 643
             +L+ C +L  L +R+D      +E           K  G  LGI+I G        P D
Sbjct: 1077 ALLRPCLEL-SLLVRRDPAPPGLRE-------LCIQKAPGERLGISIRGGARGHAGNPRD 1128

Query: 644  P----IIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKI 699
            P    I IS ++  G A R G + +G R+L +N  SL G    EA+ LL+  G+T+T+ +
Sbjct: 1129 PTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188

Query: 700  ----KKQTDAQSASSPKKF--PIS------SHLSDLGDVEEDSSPAQKPGKLSDMYPSTV 747
                +  TDA    SP     P +      + L  +  ++ + SP + PGK  ++   T+
Sbjct: 1189 CDGFEASTDAALEVSPGVIANPFAAGIGHRNSLESISSIDRELSP-EGPGKEKELPGQTL 1247



 Score = 77.0 bits (188), Expect = 9e-14
 Identities = 88/358 (24%), Positives = 147/358 (41%), Gaps = 88/358 (24%)

Query: 417  ETTEVVLTADPVTG-FGIQLQGSVFATETLSSPP--LISYIEADSPAERCGVLQIGDRVM 473
            E  E+ LT    TG  GI + G   +T          IS +  + PA R GV ++GD+++
Sbjct: 723  EEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGV-RVGDKLL 781

Query: 474  AINGIPTEDSTFEEASQLLR--DSSITSKVTLE--IEFDVAESVIP-------------- 515
             +NG+  + +   EA + LR   +++  +V  E  +E + A ++ P              
Sbjct: 782  EVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRG 841

Query: 516  -----------SSGTF---HVKLPKKHNVELGITISSPSSRKP---GDP-LVISDIKKGS 557
                       S G     HV    +    LG +I+      P   GD  + +S I +G 
Sbjct: 842  GGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGG 901

Query: 558  VAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDN-------SD 610
             AHR GTL++GD++L+I+ + +     + AV +L      + L + ++            
Sbjct: 902  AAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPH 961

Query: 611  EQESSGAIIYT--------------------------------VELKRYGGPLGITISG- 637
                + A+  T                                + L R GGPLG++I G 
Sbjct: 962  SSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGG 1021

Query: 638  ---TEEPF---DP-IIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLL 688
               +  PF   +P + IS +   GLA R+G + +GDRILA+N   ++     EA+  L
Sbjct: 1022 SDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSAL 1078



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 62/192 (32%), Positives = 89/192 (46%), Gaps = 24/192 (12%)

Query: 57   MKKEGTTLGLTVSGGIDKDGKPR--------VSNLRQGGIAARSDQLDVGDYIKAVNGIN 108
            + + G  LGL++ GG D    P         +S +   G+AARS  L VGD I AVNG +
Sbjct: 1007 LPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQD 1065

Query: 109  LAKFRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKE-GNTFGFVIR 167
            +    H E +S L      + L V  +  P  ++         E+ + K  G   G  IR
Sbjct: 1066 VRDATHQEAVSALLRPCLELSLLVRRDPAPPGLR---------ELCIQKAPGERLGISIR 1116

Query: 168  GGAHDDRNKSRP-----VVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSI 222
            GGA       R      + I+ V P G A R+G ++ G RLL V+   LLG TH EA+ +
Sbjct: 1117 GGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQL 1176

Query: 223  LKQCGQEAALLI 234
            L+  G    +L+
Sbjct: 1177 LRSVGDTLTVLV 1188



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 81/345 (23%), Positives = 130/345 (37%), Gaps = 91/345 (26%)

Query: 64   LGLTVSGGIDKDGKPR--------VSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHD 115
            LG++++GG  K   P         +S + + G AAR+  + VGD +  VNG+ L    H 
Sbjct: 738  LGISIAGG--KGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHH 794

Query: 116  EIISLLKNVGERVVLEVEYE-------------------------------LPPVSVQGS 144
            E +  L+  G  V + V  E                               LP +  +  
Sbjct: 795  EAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESP 854

Query: 145  SVIFRTVEVTLHKEGNTFGFVIRGGAHDD--RNKSRPVVITCVRPGGPADREGTIKPGDR 202
              + +     L +     GF I GG      R     + ++ +  GG A R GT++ GDR
Sbjct: 855  GPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDR 914

Query: 203  LLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVS------------------VMDSV 244
            +LS++G+ +    H  A+S+L       ALL+E +                       S+
Sbjct: 915  VLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSI 974

Query: 245  ATAS-------------------GPLLVEVAKTP--GASLGVAL-------TTSMCCNKQ 276
             TA+                   GP  VE  + P  G  LG+++       +      + 
Sbjct: 975  TTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEP 1034

Query: 277  VIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFL 321
             + I K+    +A R G L VGD IL+++G  +   T  EA   L
Sbjct: 1035 GVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSAL 1078



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 54/222 (24%), Positives = 94/222 (42%), Gaps = 43/222 (19%)

Query: 532 LGITISSPSSRKP--GDP--LVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDA 587
           LGI+I+      P  GD   + IS + +   A R G + +GDKLL ++ + L      +A
Sbjct: 738 LGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHEA 796

Query: 588 VQILQQCEDLVKLKI-----------------RKDEDNSDEQESSGAIIYTVELKRYGGP 630
           V+ L+     V++++                 R ++D S  +   G +   +      GP
Sbjct: 797 VEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPGP 856

Query: 631 L---------------GITISGTE--EPFDP----IIISSLTKGGLAERTGAIHIGDRIL 669
           L               G +I+G +   P+      I +S + +GG A R G + +GDR+L
Sbjct: 857 LRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVL 916

Query: 670 AINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQSASSP 711
           +IN   +       A+ LL  A  T+ L ++++       SP
Sbjct: 917 SINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSP 958



 Score = 35.8 bits (81), Expect = 0.22
 Identities = 46/201 (22%), Positives = 74/201 (36%), Gaps = 18/201 (8%)

Query: 863  DRRVSLRNMTLLATIMSGSTMSLNHEAPTPRSQLGRQASFQERSSSRPHYSQTTRSNT-- 920
            DR +S+  + +       +   L   +PT    L R+A      S  PH S  T +    
Sbjct: 913  DRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATT 972

Query: 921  -----------LPSDVGRKSVTLRKMKQEIKEIMSPTPVELHKVTLYKDSDMEDFGFSVA 969
                       LPS          +    ++EI  P       +++   SD     F   
Sbjct: 973  SITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPF--- 1029

Query: 970  DGLLEKGVYVKNIRPAGPGDLGGLKPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLV 1029
             G+ E GV++  + P G     GL+  DR+L VN    RD      V  +     +L L+
Sbjct: 1030 -GVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLL 1088

Query: 1030 ISRNPL-ASQKSIDQQSLPGD 1049
            + R+P     + +  Q  PG+
Sbjct: 1089 VRRDPAPPGLRELCIQKAPGE 1109



 Score = 32.7 bits (73), Expect = 1.9
 Identities = 27/145 (18%), Positives = 59/145 (40%), Gaps = 7/145 (4%)

Query: 903  QERSSSRPHYSQTTRSNTLPSDVGRKSVTLRKMKQEIKEIMSPTPVELHKVTLYKDSDME 962
            +E + +    + T   +   + V   SV      Q    ++ P  +E  ++TL       
Sbjct: 677  EEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPARIEEEELTLTILRQTG 736

Query: 963  DFGFSVADGLL-------EKGVYVKNIRPAGPGDLGGLKPYDRLLQVNHVRTRDFDCCLV 1015
              G S+A G         ++G+++  +   GP    G++  D+LL+VN V  +  +    
Sbjct: 737  GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEA 796

Query: 1016 VPLIAESGNKLDLVISRNPLASQKS 1040
            V  +  +G  + + + R  +   ++
Sbjct: 797  VEALRGAGTAVQMRVWRERMVEPEN 821


>gi|45827731 scribble isoform a [Homo sapiens]
          Length = 1655

 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 87/319 (27%), Positives = 131/319 (41%), Gaps = 64/319 (20%)

Query: 64   LGLTVSGGIDK------DGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEI 117
            LG +++GG         D    VS + +GG A R+  L VGD + ++NG+++ + RHD  
Sbjct: 872  LGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHA 931

Query: 118  ISLLKNVGERVVLEVEYE----LPPVSVQGSSVIFRTV---------------------- 151
            +SLL      + L +E E    LPP  +  SS     V                      
Sbjct: 932  VSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSL 991

Query: 152  ------------EVTLHKEGNTFGFVIRGGA----HDDRNKSRPVVITCVRPGGPADREG 195
                        E+ L + G   G  I GG+    H    +   V I+ V P G A R G
Sbjct: 992  LAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG 1051

Query: 196  TIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASGPLLVEV 255
             ++ GDR+L+V+G  +   TH EA+S L +   E +LL+  D           G   + +
Sbjct: 1052 -LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRD-------PAPPGLRELCI 1103

Query: 256  AKTPGASLGVALT--------TSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGT 307
             K PG  LG+++                + I I K+     A R G L VG  +L ++  
Sbjct: 1104 QKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQ 1163

Query: 308  SMEYCTLAEATQFLANTTD 326
            S+   T  EA Q L +  D
Sbjct: 1164 SLLGLTHGEAVQLLRSVGD 1182



 Score = 84.0 bits (206), Expect = 7e-16
 Identities = 123/502 (24%), Positives = 188/502 (37%), Gaps = 94/502 (18%)

Query: 153  VTLHKEGNTFGFVIRGGAHDDRNKS--RPVVITCVRPGGPADREGTIKPGDRLLSVDGIR 210
            +T+ ++    G  I GG      K     + I+ V   GPA R G ++ GD+LL V+G+ 
Sbjct: 729  LTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVA 787

Query: 211  LLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASGPLLVEVAKTPGASLGVAL--- 267
            L G  H EA+  L+  G    + +  +  V    A    PL  E   +P    G  L   
Sbjct: 788  LQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLP 847

Query: 268  ----------------------------------TTSMCCNKQVIVIDKIKSASIADRCG 293
                                              +T        I + +I     A R G
Sbjct: 848  LLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAG 907

Query: 294  ALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEIL-----PHHQTRLALKGPDHA 348
             L VGD +LSI+G  +       A   L   +  + L +      P   + L    P  A
Sbjct: 908  TLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTA 967

Query: 349  ALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVG 408
            A+ ++S +  +     L SL    L  +L    P   +   RL +      LS+    VG
Sbjct: 968  AVATTSITTATPGVPGLPSLAPSLLAAALEGPYP---VEEIRLPRAGGPLGLSI----VG 1020

Query: 409  LAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQI 468
             +    H               FG+Q  G VF          IS +     A R G L++
Sbjct: 1021 GSDHSSHP--------------FGVQEPG-VF----------ISKVLPRGLAARSG-LRV 1054

Query: 469  GDRVMAINGIPTEDSTFEEA-SQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKK 527
            GDR++A+NG    D+T +EA S LLR         LE+   V     P  G   + + K 
Sbjct: 1055 GDRILAVNGQDVRDATHQEAVSALLRP-------CLELSLLVRRDPAP-PGLRELCIQKA 1106

Query: 528  HNVELGITISSPSSRKPGDP-------LVISDIKKGSVAHRTGTLELGDKLLAIDNIRLD 580
                LGI+I   +    G+P       + IS +     A R G L +G +LL ++   L 
Sbjct: 1107 PGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLL 1166

Query: 581  NCSMEDAVQILQQCEDLVKLKI 602
              +  +AVQ+L+   D + + +
Sbjct: 1167 GLTHGEAVQLLRSVGDTLTVLV 1188



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 128/540 (23%), Positives = 209/540 (38%), Gaps = 120/540 (22%)

Query: 278  IVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQ 337
            I I ++     A R G + VGD +L ++G +++     EA + L      V++ +     
Sbjct: 758  IFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVW---- 812

Query: 338  TRLALKGPDHAALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFK 397
             R  +  P++A  ++          YS      G L   L      G + +R +      
Sbjct: 813  -RERMVEPENAVTITPLRPEDD---YSPRERRGGGLRLPLLPPESPGPLRQRHVA----- 863

Query: 398  SSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEAD 457
                LA S  GL   +   + +      D     GI                 +S I   
Sbjct: 864  ---CLARSERGLGFSIAGGKGSTPYRAGDA----GI----------------FVSRIAEG 900

Query: 458  SPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVAESVIPSS 517
              A R G LQ+GDRV++ING+   ++  + A  LL  +S T  + LE E   A   +P S
Sbjct: 901  GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLERE---AGGPLPPS 957

Query: 518  GTFHVKLPKKHNVELGITISSPSSR--------------------------KPGDPL--- 548
               H   P        IT ++P                             + G PL   
Sbjct: 958  PLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLS 1017

Query: 549  -------------------VISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQ 589
                                IS +    +A R+G L +GD++LA++   + + + ++AV 
Sbjct: 1018 IVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVS 1076

Query: 590  -ILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISG-----TEEPFD 643
             +L+ C +L  L +R+D      +E           K  G  LGI+I G        P D
Sbjct: 1077 ALLRPCLEL-SLLVRRDPAPPGLRE-------LCIQKAPGERLGISIRGGARGHAGNPRD 1128

Query: 644  P----IIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKI 699
            P    I IS ++  G A R G + +G R+L +N  SL G    EA+ LL+  G+T+T+ +
Sbjct: 1129 PTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188

Query: 700  ----KKQTDAQSASSPKKF--PIS------SHLSDLGDVEEDSSPAQKPGKLSDMYPSTV 747
                +  TDA    SP     P +      + L  +  ++ + SP + PGK  ++   T+
Sbjct: 1189 CDGFEASTDAALEVSPGVIANPFAAGIGHRNSLESISSIDRELSP-EGPGKEKELPGQTL 1247



 Score = 77.0 bits (188), Expect = 9e-14
 Identities = 88/358 (24%), Positives = 147/358 (41%), Gaps = 88/358 (24%)

Query: 417  ETTEVVLTADPVTG-FGIQLQGSVFATETLSSPP--LISYIEADSPAERCGVLQIGDRVM 473
            E  E+ LT    TG  GI + G   +T          IS +  + PA R GV ++GD+++
Sbjct: 723  EEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGV-RVGDKLL 781

Query: 474  AINGIPTEDSTFEEASQLLR--DSSITSKVTLE--IEFDVAESVIP-------------- 515
             +NG+  + +   EA + LR   +++  +V  E  +E + A ++ P              
Sbjct: 782  EVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRG 841

Query: 516  -----------SSGTF---HVKLPKKHNVELGITISSPSSRKP---GDP-LVISDIKKGS 557
                       S G     HV    +    LG +I+      P   GD  + +S I +G 
Sbjct: 842  GGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGG 901

Query: 558  VAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDN-------SD 610
             AHR GTL++GD++L+I+ + +     + AV +L      + L + ++            
Sbjct: 902  AAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPH 961

Query: 611  EQESSGAIIYT--------------------------------VELKRYGGPLGITISG- 637
                + A+  T                                + L R GGPLG++I G 
Sbjct: 962  SSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGG 1021

Query: 638  ---TEEPF---DP-IIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLL 688
               +  PF   +P + IS +   GLA R+G + +GDRILA+N   ++     EA+  L
Sbjct: 1022 SDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSAL 1078



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 62/192 (32%), Positives = 89/192 (46%), Gaps = 24/192 (12%)

Query: 57   MKKEGTTLGLTVSGGIDKDGKPR--------VSNLRQGGIAARSDQLDVGDYIKAVNGIN 108
            + + G  LGL++ GG D    P         +S +   G+AARS  L VGD I AVNG +
Sbjct: 1007 LPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQD 1065

Query: 109  LAKFRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKE-GNTFGFVIR 167
            +    H E +S L      + L V  +  P  ++         E+ + K  G   G  IR
Sbjct: 1066 VRDATHQEAVSALLRPCLELSLLVRRDPAPPGLR---------ELCIQKAPGERLGISIR 1116

Query: 168  GGAHDDRNKSRP-----VVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSI 222
            GGA       R      + I+ V P G A R+G ++ G RLL V+   LLG TH EA+ +
Sbjct: 1117 GGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQL 1176

Query: 223  LKQCGQEAALLI 234
            L+  G    +L+
Sbjct: 1177 LRSVGDTLTVLV 1188



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 81/345 (23%), Positives = 130/345 (37%), Gaps = 91/345 (26%)

Query: 64   LGLTVSGGIDKDGKPR--------VSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHD 115
            LG++++GG  K   P         +S + + G AAR+  + VGD +  VNG+ L    H 
Sbjct: 738  LGISIAGG--KGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHH 794

Query: 116  EIISLLKNVGERVVLEVEYE-------------------------------LPPVSVQGS 144
            E +  L+  G  V + V  E                               LP +  +  
Sbjct: 795  EAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESP 854

Query: 145  SVIFRTVEVTLHKEGNTFGFVIRGGAHDD--RNKSRPVVITCVRPGGPADREGTIKPGDR 202
              + +     L +     GF I GG      R     + ++ +  GG A R GT++ GDR
Sbjct: 855  GPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDR 914

Query: 203  LLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVS------------------VMDSV 244
            +LS++G+ +    H  A+S+L       ALL+E +                       S+
Sbjct: 915  VLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSI 974

Query: 245  ATAS-------------------GPLLVEVAKTP--GASLGVAL-------TTSMCCNKQ 276
             TA+                   GP  VE  + P  G  LG+++       +      + 
Sbjct: 975  TTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEP 1034

Query: 277  VIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFL 321
             + I K+    +A R G L VGD IL+++G  +   T  EA   L
Sbjct: 1035 GVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSAL 1078



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 54/222 (24%), Positives = 94/222 (42%), Gaps = 43/222 (19%)

Query: 532 LGITISSPSSRKP--GDP--LVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDA 587
           LGI+I+      P  GD   + IS + +   A R G + +GDKLL ++ + L      +A
Sbjct: 738 LGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHEA 796

Query: 588 VQILQQCEDLVKLKI-----------------RKDEDNSDEQESSGAIIYTVELKRYGGP 630
           V+ L+     V++++                 R ++D S  +   G +   +      GP
Sbjct: 797 VEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPGP 856

Query: 631 L---------------GITISGTE--EPFDP----IIISSLTKGGLAERTGAIHIGDRIL 669
           L               G +I+G +   P+      I +S + +GG A R G + +GDR+L
Sbjct: 857 LRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVL 916

Query: 670 AINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQSASSP 711
           +IN   +       A+ LL  A  T+ L ++++       SP
Sbjct: 917 SINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSP 958



 Score = 35.8 bits (81), Expect = 0.22
 Identities = 46/201 (22%), Positives = 74/201 (36%), Gaps = 18/201 (8%)

Query: 863  DRRVSLRNMTLLATIMSGSTMSLNHEAPTPRSQLGRQASFQERSSSRPHYSQTTRSNT-- 920
            DR +S+  + +       +   L   +PT    L R+A      S  PH S  T +    
Sbjct: 913  DRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATT 972

Query: 921  -----------LPSDVGRKSVTLRKMKQEIKEIMSPTPVELHKVTLYKDSDMEDFGFSVA 969
                       LPS          +    ++EI  P       +++   SD     F   
Sbjct: 973  SITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPF--- 1029

Query: 970  DGLLEKGVYVKNIRPAGPGDLGGLKPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLV 1029
             G+ E GV++  + P G     GL+  DR+L VN    RD      V  +     +L L+
Sbjct: 1030 -GVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLL 1088

Query: 1030 ISRNPL-ASQKSIDQQSLPGD 1049
            + R+P     + +  Q  PG+
Sbjct: 1089 VRRDPAPPGLRELCIQKAPGE 1109



 Score = 32.7 bits (73), Expect = 1.9
 Identities = 27/145 (18%), Positives = 59/145 (40%), Gaps = 7/145 (4%)

Query: 903  QERSSSRPHYSQTTRSNTLPSDVGRKSVTLRKMKQEIKEIMSPTPVELHKVTLYKDSDME 962
            +E + +    + T   +   + V   SV      Q    ++ P  +E  ++TL       
Sbjct: 677  EEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPARIEEEELTLTILRQTG 736

Query: 963  DFGFSVADGLL-------EKGVYVKNIRPAGPGDLGGLKPYDRLLQVNHVRTRDFDCCLV 1015
              G S+A G         ++G+++  +   GP    G++  D+LL+VN V  +  +    
Sbjct: 737  GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEA 796

Query: 1016 VPLIAESGNKLDLVISRNPLASQKS 1040
            V  +  +G  + + + R  +   ++
Sbjct: 797  VEALRGAGTAVQMRVWRERMVEPEN 821


>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
          Length = 975

 Score = 83.6 bits (205), Expect = 9e-16
 Identities = 107/455 (23%), Positives = 193/455 (42%), Gaps = 56/455 (12%)

Query: 141 VQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRP-VVITCVRPGGPADREGTIKP 199
           V G+ + +   E+TL +  +  GF I GG  +      P + IT + PGG A  +G ++ 
Sbjct: 192 VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRV 251

Query: 200 GDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASGPLLVEVAKTP 259
            D +L V+ + +   +H++A+  LK+ G    L +     ++++V       L +  K  
Sbjct: 252 NDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIK---LFKGPKGL 308

Query: 260 GASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQ 319
           G S+   +          I + KI     A + G L VGD +L ++  S+E  T  EA  
Sbjct: 309 GFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVA 368

Query: 320 FLANTTDQVKLEILPHHQTRLALKGPDHAALVSSSFSPTSMSAYSLSSLNMGTLPRSLYS 379
            L NT++ V L++     T + +  P     ++ S+SP  M  + LS  N GTL      
Sbjct: 369 ILKNTSEVVYLKV--GKPTTIYMTDPYGPPDITHSYSP-PMENHLLSG-NNGTL------ 418

Query: 380 TSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSV 439
                          ++K+SL   S      G+  ++   + +L  D  T     +  +V
Sbjct: 419 ---------------EYKTSLPPIS-----PGR--YSPIPKHMLVDDDYTRPPEPVYSTV 456

Query: 440 -FATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIP-TEDSTFEEASQLLRDSSI 497
               +  +SP   S +E D    +  +L        +  +P +E ++  + S   R  S+
Sbjct: 457 NKLCDKPASPRHYSPVECD----KSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSM 512

Query: 498 TSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITISSPSSRKPGDPLVISDIKKGS 557
           T +  + +E +  + V+            K +  LG  I      + G+ + +S I  G 
Sbjct: 513 TLQRAVSLEGEPRKVVL-----------HKGSTGLGFNI---VGGEDGEGIFVSFILAGG 558

Query: 558 VAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQ 592
            A  +G L+ GD++L+++ I L   S E A   L+
Sbjct: 559 PADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 593



 Score = 77.0 bits (188), Expect = 9e-14
 Identities = 53/184 (28%), Positives = 87/184 (47%), Gaps = 14/184 (7%)

Query: 57  MKKEGTTLGLTVSGGIDK-----DGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAK 111
           +++  + LG +++GG D      D    ++ +  GG AA   +L V D I  VN +++++
Sbjct: 206 LERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSE 265

Query: 112 FRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAH 171
             H + +  LK  G  V L V    P        ++   VE+ L K     GF I GG  
Sbjct: 266 VSHSKAVEALKEAGSIVRLYVRRRRP--------ILETVVEIKLFKGPKGLGFSIAGGVG 317

Query: 172 DDRNKS-RPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEA 230
           +        + +T +  GG A ++G ++ GDRLL V+   L   TH EA++ILK   +  
Sbjct: 318 NQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVV 377

Query: 231 ALLI 234
            L +
Sbjct: 378 YLKV 381



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 66/239 (27%), Positives = 113/239 (47%), Gaps = 36/239 (15%)

Query: 526 KKHNVELGITISSPSSRKP--GDP-LVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNC 582
           ++ N  LG +I+  +       DP + I+ I  G  A   G L + D +L ++ + +   
Sbjct: 207 ERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEV 266

Query: 583 SMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGP--LGITISG--- 637
           S   AV+ L++   +V+L +R+     +           VE+K + GP  LG +I+G   
Sbjct: 267 SHSKAVEALKEAGSIVRLYVRRRRPILET---------VVEIKLFKGPKGLGFSIAGGVG 317

Query: 638 -TEEPFD-PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETV 695
               P D  I ++ +  GG A++ G + +GDR+L +N+ SL+     EA+ +L+   E V
Sbjct: 318 NQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVV 377

Query: 696 TLKIKKQT-----------DAQSASSPKKFPISSHL--SDLGDVE-EDSSPAQKPGKLS 740
            LK+ K T           D   + SP   P+ +HL   + G +E + S P   PG+ S
Sbjct: 378 YLKVGKPTTIYMTDPYGPPDITHSYSP---PMENHLLSGNNGTLEYKTSLPPISPGRYS 433



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 31/85 (36%), Positives = 48/85 (56%), Gaps = 5/85 (5%)

Query: 152 EVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRL 211
           +V LHK     GF I GG   +      + ++ +  GGPAD  G ++ GD++LSV+GI L
Sbjct: 526 KVVLHKGSTGLGFNIVGGEDGEG-----IFVSFILAGGPADLSGELQRGDQILSVNGIDL 580

Query: 212 LGTTHAEAMSILKQCGQEAALLIEY 236
            G +H +A + LK  GQ   ++ +Y
Sbjct: 581 RGASHEQAAAALKGAGQTVTIIAQY 605



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 70/275 (25%), Positives = 118/275 (42%), Gaps = 34/275 (12%)

Query: 460 AERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSS--ITSKVTLEIEFDVAESVIPSS 517
           A++ G LQ+GDR++ +N    E+ T EEA  +L+++S  +  KV       + +   P  
Sbjct: 338 AQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPD 397

Query: 518 GTFHVKLPKKHNVELGI--TISSPSSRKPGDPLVISDIKKGSVAHRTGTL---------- 565
            T     P ++++  G   T+   +S  P  P   S I K  +     T           
Sbjct: 398 ITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVN 457

Query: 566 ELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDED-NSDEQESSGAIIYTVEL 624
           +L DK  +  +     C   D   +L        L +  D +  S  Q S+     ++ L
Sbjct: 458 KLCDKPASPRHYSPVEC---DKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTL 514

Query: 625 KRY----GGP-----------LGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRIL 669
           +R     G P           LG  I G E+  + I +S +  GG A+ +G +  GD+IL
Sbjct: 515 QRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDG-EGIFVSFILAGGPADLSGELQRGDQIL 573

Query: 670 AINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTD 704
           ++N   L+G    +A   L+ AG+TVT+  + Q +
Sbjct: 574 SVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPE 608



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 30/87 (34%), Positives = 48/87 (55%), Gaps = 6/87 (6%)

Query: 52  TVVELMKKEGTT-LGLTVSGGIDK-----DGKPRVSNLRQGGIAARSDQLDVGDYIKAVN 105
           TVVE+   +G   LG +++GG+       D    V+ +  GG A +  +L VGD +  VN
Sbjct: 295 TVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVN 354

Query: 106 GINLAKFRHDEIISLLKNVGERVVLEV 132
             +L +  H+E +++LKN  E V L+V
Sbjct: 355 NYSLEEVTHEEAVAILKNTSEVVYLKV 381



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 29/80 (36%), Positives = 44/80 (55%), Gaps = 1/80 (1%)

Query: 56  LMKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHD 115
           ++ K  T LG  + GG D +G   VS +  GG A  S +L  GD I +VNGI+L    H+
Sbjct: 528 VLHKGSTGLGFNIVGGEDGEGI-FVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 586

Query: 116 EIISLLKNVGERVVLEVEYE 135
           +  + LK  G+ V +  +Y+
Sbjct: 587 QAAAALKGAGQTVTIIAQYQ 606



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 29/124 (23%), Positives = 58/124 (46%), Gaps = 14/124 (11%)

Query: 451 ISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEIE---- 506
           +S+I A  PA+  G LQ GD+++++NGI    ++ E+A+  L+ +  T  +  + +    
Sbjct: 551 VSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDY 610

Query: 507 -------FDVAESVI---PSSGTFHVKLPKKHNVELGITISSPSSRKPGDPLVISDIKKG 556
                   D+ E ++    SSG+  ++  +K ++ +        S+  G P      K G
Sbjct: 611 ARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYG 670

Query: 557 SVAH 560
            + H
Sbjct: 671 DILH 674



 Score = 35.4 bits (80), Expect = 0.29
 Identities = 23/61 (37%), Positives = 33/61 (54%), Gaps = 3/61 (4%)

Query: 949  ELHKVTLYKDSDMEDFGFSVADGLLEKGVYVKNIRPAGPGDLGG-LKPYDRLLQVNHVRT 1007
            E  KV L+K S     GF++  G   +G++V  I   GP DL G L+  D++L VN +  
Sbjct: 523  EPRKVVLHKGST--GLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDL 580

Query: 1008 R 1008
            R
Sbjct: 581  R 581



 Score = 30.8 bits (68), Expect = 7.2
 Identities = 24/91 (26%), Positives = 43/91 (47%), Gaps = 9/91 (9%)

Query: 949  ELHKVTLYKDSDMEDFGFSVADGLL------EKGVYVKNIRPAGPG-DLGGLKPYDRLLQ 1001
            E  ++TL + +     GFS+A G        + G+++  I P G   + G L+  D +L+
Sbjct: 200  EFEEITLERGNS--GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILR 257

Query: 1002 VNHVRTRDFDCCLVVPLIAESGNKLDLVISR 1032
            VN V   +      V  + E+G+ + L + R
Sbjct: 258  VNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 288


>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
          Length = 870

 Score = 83.6 bits (205), Expect = 9e-16
 Identities = 107/455 (23%), Positives = 193/455 (42%), Gaps = 56/455 (12%)

Query: 141 VQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRP-VVITCVRPGGPADREGTIKP 199
           V G+ + +   E+TL +  +  GF I GG  +      P + IT + PGG A  +G ++ 
Sbjct: 87  VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRV 146

Query: 200 GDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASGPLLVEVAKTP 259
            D +L V+ + +   +H++A+  LK+ G    L +     ++++V       L +  K  
Sbjct: 147 NDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIK---LFKGPKGL 203

Query: 260 GASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQ 319
           G S+   +          I + KI     A + G L VGD +L ++  S+E  T  EA  
Sbjct: 204 GFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVA 263

Query: 320 FLANTTDQVKLEILPHHQTRLALKGPDHAALVSSSFSPTSMSAYSLSSLNMGTLPRSLYS 379
            L NT++ V L++     T + +  P     ++ S+SP  M  + LS  N GTL      
Sbjct: 264 ILKNTSEVVYLKV--GKPTTIYMTDPYGPPDITHSYSP-PMENHLLSG-NNGTL------ 313

Query: 380 TSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSV 439
                          ++K+SL   S      G+  ++   + +L  D  T     +  +V
Sbjct: 314 ---------------EYKTSLPPIS-----PGR--YSPIPKHMLVDDDYTRPPEPVYSTV 351

Query: 440 -FATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIP-TEDSTFEEASQLLRDSSI 497
               +  +SP   S +E D    +  +L        +  +P +E ++  + S   R  S+
Sbjct: 352 NKLCDKPASPRHYSPVECD----KSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSM 407

Query: 498 TSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITISSPSSRKPGDPLVISDIKKGS 557
           T +  + +E +  + V+            K +  LG  I      + G+ + +S I  G 
Sbjct: 408 TLQRAVSLEGEPRKVVL-----------HKGSTGLGFNI---VGGEDGEGIFVSFILAGG 453

Query: 558 VAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQ 592
            A  +G L+ GD++L+++ I L   S E A   L+
Sbjct: 454 PADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 488



 Score = 77.0 bits (188), Expect = 9e-14
 Identities = 53/184 (28%), Positives = 87/184 (47%), Gaps = 14/184 (7%)

Query: 57  MKKEGTTLGLTVSGGIDK-----DGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAK 111
           +++  + LG +++GG D      D    ++ +  GG AA   +L V D I  VN +++++
Sbjct: 101 LERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSE 160

Query: 112 FRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAH 171
             H + +  LK  G  V L V    P        ++   VE+ L K     GF I GG  
Sbjct: 161 VSHSKAVEALKEAGSIVRLYVRRRRP--------ILETVVEIKLFKGPKGLGFSIAGGVG 212

Query: 172 DDRNKS-RPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEA 230
           +        + +T +  GG A ++G ++ GDRLL V+   L   TH EA++ILK   +  
Sbjct: 213 NQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVV 272

Query: 231 ALLI 234
            L +
Sbjct: 273 YLKV 276



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 66/239 (27%), Positives = 113/239 (47%), Gaps = 36/239 (15%)

Query: 526 KKHNVELGITISSPSSRKP--GDP-LVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNC 582
           ++ N  LG +I+  +       DP + I+ I  G  A   G L + D +L ++ + +   
Sbjct: 102 ERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEV 161

Query: 583 SMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGP--LGITISG--- 637
           S   AV+ L++   +V+L +R+     +           VE+K + GP  LG +I+G   
Sbjct: 162 SHSKAVEALKEAGSIVRLYVRRRRPILET---------VVEIKLFKGPKGLGFSIAGGVG 212

Query: 638 -TEEPFD-PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETV 695
               P D  I ++ +  GG A++ G + +GDR+L +N+ SL+     EA+ +L+   E V
Sbjct: 213 NQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVV 272

Query: 696 TLKIKKQT-----------DAQSASSPKKFPISSHL--SDLGDVE-EDSSPAQKPGKLS 740
            LK+ K T           D   + SP   P+ +HL   + G +E + S P   PG+ S
Sbjct: 273 YLKVGKPTTIYMTDPYGPPDITHSYSP---PMENHLLSGNNGTLEYKTSLPPISPGRYS 328



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 31/85 (36%), Positives = 48/85 (56%), Gaps = 5/85 (5%)

Query: 152 EVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRL 211
           +V LHK     GF I GG   +      + ++ +  GGPAD  G ++ GD++LSV+GI L
Sbjct: 421 KVVLHKGSTGLGFNIVGGEDGEG-----IFVSFILAGGPADLSGELQRGDQILSVNGIDL 475

Query: 212 LGTTHAEAMSILKQCGQEAALLIEY 236
            G +H +A + LK  GQ   ++ +Y
Sbjct: 476 RGASHEQAAAALKGAGQTVTIIAQY 500



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 70/275 (25%), Positives = 118/275 (42%), Gaps = 34/275 (12%)

Query: 460 AERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSS--ITSKVTLEIEFDVAESVIPSS 517
           A++ G LQ+GDR++ +N    E+ T EEA  +L+++S  +  KV       + +   P  
Sbjct: 233 AQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPD 292

Query: 518 GTFHVKLPKKHNVELGI--TISSPSSRKPGDPLVISDIKKGSVAHRTGTL---------- 565
            T     P ++++  G   T+   +S  P  P   S I K  +     T           
Sbjct: 293 ITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVN 352

Query: 566 ELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDED-NSDEQESSGAIIYTVEL 624
           +L DK  +  +     C   D   +L        L +  D +  S  Q S+     ++ L
Sbjct: 353 KLCDKPASPRHYSPVEC---DKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTL 409

Query: 625 KRY----GGP-----------LGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRIL 669
           +R     G P           LG  I G E+  + I +S +  GG A+ +G +  GD+IL
Sbjct: 410 QRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDG-EGIFVSFILAGGPADLSGELQRGDQIL 468

Query: 670 AINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTD 704
           ++N   L+G    +A   L+ AG+TVT+  + Q +
Sbjct: 469 SVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPE 503



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 30/87 (34%), Positives = 48/87 (55%), Gaps = 6/87 (6%)

Query: 52  TVVELMKKEGTT-LGLTVSGGIDK-----DGKPRVSNLRQGGIAARSDQLDVGDYIKAVN 105
           TVVE+   +G   LG +++GG+       D    V+ +  GG A +  +L VGD +  VN
Sbjct: 190 TVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVN 249

Query: 106 GINLAKFRHDEIISLLKNVGERVVLEV 132
             +L +  H+E +++LKN  E V L+V
Sbjct: 250 NYSLEEVTHEEAVAILKNTSEVVYLKV 276



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 29/80 (36%), Positives = 44/80 (55%), Gaps = 1/80 (1%)

Query: 56  LMKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHD 115
           ++ K  T LG  + GG D +G   VS +  GG A  S +L  GD I +VNGI+L    H+
Sbjct: 423 VLHKGSTGLGFNIVGGEDGEGI-FVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 481

Query: 116 EIISLLKNVGERVVLEVEYE 135
           +  + LK  G+ V +  +Y+
Sbjct: 482 QAAAALKGAGQTVTIIAQYQ 501



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 29/124 (23%), Positives = 58/124 (46%), Gaps = 14/124 (11%)

Query: 451 ISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEIE---- 506
           +S+I A  PA+  G LQ GD+++++NGI    ++ E+A+  L+ +  T  +  + +    
Sbjct: 446 VSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDY 505

Query: 507 -------FDVAESVI---PSSGTFHVKLPKKHNVELGITISSPSSRKPGDPLVISDIKKG 556
                   D+ E ++    SSG+  ++  +K ++ +        S+  G P      K G
Sbjct: 506 ARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYG 565

Query: 557 SVAH 560
            + H
Sbjct: 566 DILH 569



 Score = 35.4 bits (80), Expect = 0.29
 Identities = 23/61 (37%), Positives = 33/61 (54%), Gaps = 3/61 (4%)

Query: 949  ELHKVTLYKDSDMEDFGFSVADGLLEKGVYVKNIRPAGPGDLGG-LKPYDRLLQVNHVRT 1007
            E  KV L+K S     GF++  G   +G++V  I   GP DL G L+  D++L VN +  
Sbjct: 418  EPRKVVLHKGST--GLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDL 475

Query: 1008 R 1008
            R
Sbjct: 476  R 476



 Score = 30.8 bits (68), Expect = 7.2
 Identities = 24/91 (26%), Positives = 43/91 (47%), Gaps = 9/91 (9%)

Query: 949  ELHKVTLYKDSDMEDFGFSVADGLL------EKGVYVKNIRPAGPG-DLGGLKPYDRLLQ 1001
            E  ++TL + +     GFS+A G        + G+++  I P G   + G L+  D +L+
Sbjct: 95   EFEEITLERGNS--GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILR 152

Query: 1002 VNHVRTRDFDCCLVVPLIAESGNKLDLVISR 1032
            VN V   +      V  + E+G+ + L + R
Sbjct: 153  VNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 183


>gi|218505835 membrane-associated guanylate kinase-related  3 isoform
            1 [Homo sapiens]
          Length = 1481

 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 91/420 (21%), Positives = 169/420 (40%), Gaps = 58/420 (13%)

Query: 149  RTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDG 208
            + ++V L K+ + FGF + GG   D++    + I  + P G A+++G ++  D L+ +DG
Sbjct: 723  KDLDVFLRKQESGFGFRVLGGDGPDQS----IYIGAIIPLGAAEKDGRLRAADELMCIDG 778

Query: 209  IRLLGTTHAEAMSILKQCGQEAALLIEY------------DVSVMDSVATASGPLLVEVA 256
            I + G +H + + ++    +   +L+              D S    ++T +G   +  A
Sbjct: 779  IPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRA 838

Query: 257  KTPGA-----------------SLGVALTTSMCCNKQVIV---IDKIKSASIADRCGALH 296
            + P                     G  + TS       ++   I ++   S ADRCG L 
Sbjct: 839  EVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLK 898

Query: 297  VGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHAALVSSSFS 356
            VGDHI +++G S+   +     Q + +    V L ++   +      GP      +S+  
Sbjct: 899  VGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHH----GPPSGT--NSARQ 952

Query: 357  PTSMSAYSLSSLNMGTLP---RSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQV 413
              ++    +       +P    +L     +      R    D K      ++ + + G  
Sbjct: 953  SPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSR 1012

Query: 414  VHTETT---EVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGD 470
             H +      V L   P  GFG  L+G     +  +    I  +  D PA + G + +GD
Sbjct: 1013 -HNQNLGCYPVELERGP-RGFGFSLRGG----KEYNMGLFILRLAEDGPAIKDGRIHVGD 1066

Query: 471  RVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNV 530
            +++ ING PT+  T   A +L++     +KV L +       +IP  G + +  P   NV
Sbjct: 1067 QIVEINGEPTQGITHTRAIELIQAGG--NKVLLLLR--PGTGLIPDHGDWDINNPSSSNV 1122



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 74/288 (25%), Positives = 119/288 (41%), Gaps = 33/288 (11%)

Query: 417  ETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAIN 476
            E  +VVL      GFG  +  S         P  I  +   SPA+RCG L++GD + A+N
Sbjct: 848  EPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVN 907

Query: 477  GIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVK-LPKKHNVELGIT 535
            G    + + +   QL++D+ +T  +T+  E    E   P SGT   +  P   +  +G  
Sbjct: 908  GQSIVELSHDNIVQLIKDAGVTVTLTVIAE---EEHHGPPSGTNSARQSPALQHRPMG-- 962

Query: 536  ISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCE 595
              S ++  PGD   +    +G +     T                  S  D   + Q   
Sbjct: 963  -QSQANHIPGDRSAL----EGEIGKDVSTSY--------------RHSWSDHKHLAQPDT 1003

Query: 596  DLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTKGGL 655
             ++ +   +   N           Y VEL+R     G ++ G +E    + I  L + G 
Sbjct: 1004 AVISVVGSRHNQNLG--------CYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGP 1055

Query: 656  AERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQT 703
            A + G IH+GD+I+ IN    +G   + AI L+Q  G  V L ++  T
Sbjct: 1056 AIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGT 1103



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 125/598 (20%), Positives = 233/598 (38%), Gaps = 92/598 (15%)

Query: 45  PEEFKGSTVVELMKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAV 104
           P + KG  V   +KK     G T+ GG   D   +V N+ + G AA+  ++  GD I  +
Sbjct: 401 PSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDI 460

Query: 105 NGINLAKFRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKEGNTFGF 164
           NG  +    H +++ +             ++L PV+   +  + R   +    E      
Sbjct: 461 NGNCVLGHTHADVVQM-------------FQLVPVNQYVNLTLCRGYPLPDDSEDPVVDI 507

Query: 165 VIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILK 224
           V      + ++ ++    TC+ P          KPG  +L  +G +   T   + ++   
Sbjct: 508 VAATPVINGQSLTKGE--TCMNP-------QDFKPGAMVLEQNG-KSGHTLTGDGLN--- 554

Query: 225 QCGQEAALLIEYDVSVMDSVATASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIK 284
             G   A   E  VS+  S ++    + + + K P    G A+  S    K  +++D   
Sbjct: 555 --GPSDA--SEQRVSMASSGSSQPELVTIPLIKGP-KGFGFAIADSPTGQKVKMILD--- 606

Query: 285 SASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKG 344
               +  C  L  GD I  I   +++  T  +  + L        + +L      +   G
Sbjct: 607 ----SQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLL------ILRGG 656

Query: 345 PDHAALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLAS 404
           P      +   +    +A SL ++N   +P+ +    P    + R    K   S + L S
Sbjct: 657 PPSPTKTAKMKTDKKENAGSLEAIN-EPIPQPM----PFPPSIIRSGSPKLDPSEVYLKS 711

Query: 405 STVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSP---AE 461
            T+    +  +T+  +V L     +GFG ++ G          P    YI A  P   AE
Sbjct: 712 KTL-YEDKPPNTKDLDVFLRKQE-SGFGFRVLGG-------DGPDQSIYIGAIIPLGAAE 762

Query: 462 RCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEI-----------EFDVA 510
           + G L+  D +M I+GIP +  + ++   L+  ++    V L +           E D +
Sbjct: 763 KDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSS 822

Query: 511 ESVIPSSG------------------TFHVKLPKKHNVELGITISSPSSRKPGD--PLVI 550
           ++ I +                     + V L +K N   G  I +  ++ P    P  I
Sbjct: 823 QAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKI 882

Query: 551 SDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDN 608
             + +GS A R G L++GD + A++   +   S ++ VQ+++     V L +  +E++
Sbjct: 883 GRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEH 940



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 143/661 (21%), Positives = 235/661 (35%), Gaps = 126/661 (19%)

Query: 151 VEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIR 210
           V  +L K    FGF I GG   D      + +  V   GPA ++G I PGD ++ ++G  
Sbjct: 409 VRASLKKSTMGFGFTIIGGDRPDEF----LQVKNVLKDGPAAQDGKIAPGDVIVDINGNC 464

Query: 211 LLGTTHAEAMSI--LKQCGQEAALLIEYDVSVMDSVATASGPLLVEVAKTPGASLGVALT 268
           +LG THA+ + +  L    Q   L +     + D    +  P++  VA TP  + G +LT
Sbjct: 465 VLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDD---SEDPVVDIVAATPVIN-GQSLT 520

Query: 269 T-SMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQ 327
               C N Q    D    A + ++ G      H L+ DG +       +     ++ + Q
Sbjct: 521 KGETCMNPQ----DFKPGAMVLEQNGK---SGHTLTGDGLNGPSDASEQRVSMASSGSSQ 573

Query: 328 VKLEILPHHQTRLALKGPDHAALVSSSFSPTSMSAYSL------SSLNMGTLPRSLYSTS 381
            +L  +P       +KGP       +  SPT      +        L  G + + +Y  +
Sbjct: 574 PELVTIP------LIKGPKGFGFAIAD-SPTGQKVKMILDSQWCQGLQKGDIIKEIYHQN 626

Query: 382 PRGTMMRRRLKKKDFKSSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFA 441
            +                             + H +  E VL   PV G  + L   +  
Sbjct: 627 VQ----------------------------NLTHLQVVE-VLKQFPV-GADVPL---LIL 653

Query: 442 TETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKV 501
                SP   + ++ D   E  G L+  +  +    +P   S     S  L  S +  K 
Sbjct: 654 RGGPPSPTKTAKMKTDK-KENAGSLEAINEPIP-QPMPFPPSIIRSGSPKLDPSEVYLK- 710

Query: 502 TLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITISSPSSRKPGDPLVISDIKKGSVAHR 561
                  + E   P++    V L K+   E G          P   + I  I     A +
Sbjct: 711 ----SKTLYEDKPPNTKDLDVFLRKQ---ESGFGFRVLGGDGPDQSIYIGAIIPLGAAEK 763

Query: 562 TGTLELGDKLLAIDNIRLDNCSMEDAVQILQQC--EDLVKLKIRKD---EDNSDEQESSG 616
            G L   D+L+ ID I +   S +  + ++        V L +R+     +   E +SS 
Sbjct: 764 DGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQ 823

Query: 617 AIIYT----VELKRYGGPLGITISGTEEPFDPII-------------------------- 646
           A I T      L R   P        +EP+D ++                          
Sbjct: 824 AFISTQNGSPRLNRAEVP---ARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPH 880

Query: 647 -ISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTDA 705
            I  + +G  A+R G + +GD I A+N  S+        + L++ AG TVTL +  + + 
Sbjct: 881 KIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEH 940

Query: 706 QSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDMYPSTVPSVDSAVDSWDGSAIDTS 765
               S             G      SPA +   +     + +P   SA++   G  + TS
Sbjct: 941 HGPPS-------------GTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTS 987

Query: 766 Y 766
           Y
Sbjct: 988 Y 988



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 67/292 (22%), Positives = 111/292 (38%), Gaps = 53/292 (18%)

Query: 54   VELMKKEGTTLGLTVSGGIDKDGKP-------RVSNLRQGGIAARSDQLDVGDYIKAVNG 106
            V L +KE    G  +   +    KP       ++  + +G  A R  +L VGD+I AVNG
Sbjct: 852  VVLQRKENEGFGFVI---LTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNG 908

Query: 107  INLAKFRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKEGNTFGFVI 166
             ++ +  HD I+ L+K+ G  V L V                   E   H          
Sbjct: 909  QSIVELSHDNIVQLIKDAGVTVTLTV-----------------IAEEEHH---------- 941

Query: 167  RGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQC 226
              G     N +R       RP G +  +    PGDR        L G    +  +  +  
Sbjct: 942  --GPPSGTNSARQSPALQHRPMGQS--QANHIPGDR------SALEGEIGKDVSTSYRHS 991

Query: 227  GQEAALLIEYDVSVMDSVATASGPLL----VEVAKTPGASLGVALTTSMCCNKQVIVIDK 282
              +   L + D +V+  V +     L    VE+ + P    G +L      N  + ++ +
Sbjct: 992  WSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGP-RGFGFSLRGGKEYNMGLFIL-R 1049

Query: 283  IKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILP 334
            +     A + G +HVGD I+ I+G   +  T   A + +    ++V L + P
Sbjct: 1050 LAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRP 1101



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 23/92 (25%), Positives = 43/92 (46%), Gaps = 1/92 (1%)

Query: 599 KLKIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAER 658
           K  + K     D  +  G ++    LK+     G TI G + P + + + ++ K G A +
Sbjct: 389 KPDMEKSHFTRDPSQLKGVLV-RASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQ 447

Query: 659 TGAIHIGDRILAINSSSLKGKPLSEAIHLLQM 690
            G I  GD I+ IN + + G   ++ + + Q+
Sbjct: 448 DGKIAPGDVIVDINGNCVLGHTHADVVQMFQL 479



 Score = 30.4 bits (67), Expect = 9.4
 Identities = 22/69 (31%), Positives = 32/69 (46%), Gaps = 11/69 (15%)

Query: 162 FGFVIRGGAHDD------RNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTT 215
           FG  IRGGA         R +  P   TC    G A       PGD LL V+G  + G T
Sbjct: 29  FGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAP-----SPGDVLLEVNGTPVSGLT 83

Query: 216 HAEAMSILK 224
           + + +++++
Sbjct: 84  NRDTLAVIR 92


>gi|148833504 interleukin 16 isoform 2 [Homo sapiens]
          Length = 1332

 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 84/322 (26%), Positives = 140/322 (43%), Gaps = 46/322 (14%)

Query: 33   PDGALAVRRQSIPEEFKGSTVVELMKKEGTTLGLTVSGGIDKDGKPRVSNLRQ---GGIA 89
            P      +   IP+E  G++      ++    G   +  +D      +S LR+   G   
Sbjct: 1006 PSSISCAQTPCIPKE--GASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGLTE 1063

Query: 90   ARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFR 149
            A+ D  D GD+    +G          +ISLL +   + ++E    L   +++    I  
Sbjct: 1064 AKED--DDGDHSSLQSG--------QSVISLLSSEELKKLIEEVKVLDEATLKQLDGIHV 1113

Query: 150  TVEVTLHKE-GNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDG 208
            T+   LHKE G   GF + GGA D  NK   + +  V P G A +EGTI+ G+ +LS++G
Sbjct: 1114 TI---LHKEEGAGLGFSLAGGA-DLENKV--ITVHRVFPNGLASQEGTIQKGNEVLSING 1167

Query: 209  IRLLGTTHAEAMSILKQCGQ-EAALLIEYDV---------SVMDSVATASGPLLVEVAKT 258
              L GTTH +A++IL+Q  +   A+++   +         S  DS A+AS    V V  T
Sbjct: 1168 KSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVEST 1227

Query: 259  PGASLGVALTTSMCC--------------NKQVIVIDKIKSASIADRCGALHVGDHILSI 304
              A++       M                  + + I++I   + +++   +  GD IL +
Sbjct: 1228 AEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQL 1287

Query: 305  DGTSMEYCTLAEATQFLANTTD 326
             GT+M+  T  EA   +    D
Sbjct: 1288 GGTAMQGLTRFEAWNIIKALPD 1309



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 57/227 (25%), Positives = 102/227 (44%), Gaps = 25/227 (11%)

Query: 46   EEFKGSTVVELMKKEGTTLGLTVSGGIDKDGKP-RVSNLRQGGIAARSDQLDVGDYIKAV 104
            ++  G  V  L K+EG  LG +++GG D + K   V  +   G+A++   +  G+ + ++
Sbjct: 1106 KQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSI 1165

Query: 105  NGINLAKFRHDEIISLLKNVGE-RVVLEVEYELPP---------------------VSVQ 142
            NG +L    H + +++L+   E R  + V  +L P                     VSV+
Sbjct: 1166 NGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVE 1225

Query: 143  GSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDR 202
             S+       VTL K     GF + GG     +  +P+ I  +  G  +++  T++PGD 
Sbjct: 1226 -STAEATVCTVTLEKMSAGLGFSLEGGK-GSLHGDKPLTINRIFKGAASEQSETVQPGDE 1283

Query: 203  LLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASG 249
            +L + G  + G T  EA +I+K        ++    S+     TA+G
Sbjct: 1284 ILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAG 1330



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 49/244 (20%), Positives = 111/244 (45%), Gaps = 37/244 (15%)

Query: 486  EEASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITISSPSSRKPG 545
            EE  +L+ +  +  + TL+             G     L K+    LG +++  +  +  
Sbjct: 1088 EELKKLIEEVKVLDEATLK----------QLDGIHVTILHKEEGAGLGFSLAGGADLE-N 1136

Query: 546  DPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCED-----LVKL 600
              + +  +    +A + GT++ G+++L+I+   L   +  DA+ IL+Q  +     +V  
Sbjct: 1137 KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTR 1196

Query: 601  KIRK----DEDNSDEQESSG-------------AIIYTVELKRYGGPLGITISGTEEPFD 643
            K+      D ++S +  +S              A + TV L++    LG ++ G +    
Sbjct: 1197 KLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLH 1256

Query: 644  ---PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQ-MAGETVTLKI 699
               P+ I+ + KG  +E++  +  GD IL +  ++++G    EA ++++ +    VT+ I
Sbjct: 1257 GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVI 1316

Query: 700  KKQT 703
            ++++
Sbjct: 1317 RRKS 1320



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 69/322 (21%), Positives = 120/322 (37%), Gaps = 54/322 (16%)

Query: 350 LVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGL 409
           +   S +PT    YSL S N  +L + L   + +     R  +     S+  L   + GL
Sbjct: 154 MTKKSAAPTDRQPYSLCS-NRKSLSQQLDCPAGKAAGTSRPTRSL---STAQLVQPSGGL 209

Query: 410 AGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPP--LISYIEADSPAERCGVLQ 467
              V+    + +VL      G G  + G     +++  P    +  I A   A   G LQ
Sbjct: 210 QASVI----SNIVLMKGQAKGLGFSIVGG---KDSIYGPIGIYVKTIFAGGAAAADGRLQ 262

Query: 468 IGDRVMAINGIPTEDSTFEEASQLLRDS-----SITSKVTLEIEFDVAESVIP------S 516
            GD ++ +NG      T ++A Q  + +     ++T +  L     +   + P      S
Sbjct: 263 EGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLS 322

Query: 517 SGT----------------------------FHVKLPKKHNVELGITISSPSSRKPGDPL 548
           S T                              V L K+  V LGI + S    +    +
Sbjct: 323 SSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGI 382

Query: 549 VISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCE--DLVKLKIRKDE 606
            +  +  GSVAH  G L  GD+++ I +  +   ++ +   IL  C+   +  +  R  +
Sbjct: 383 FVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPD 442

Query: 607 DNSDEQESSGAIIYTVELKRYG 628
               EQ+   A+   VE  ++G
Sbjct: 443 PQVSEQQLKEAVAQAVENTKFG 464



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 44/181 (24%), Positives = 83/181 (45%), Gaps = 24/181 (13%)

Query: 460  AERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSS-------ITSKVTLEIEFDV--- 509
            A + G +Q G+ V++ING   + +T  +A  +LR +        +T K+T E   D+   
Sbjct: 1150 ASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSS 1209

Query: 510  AESVIPSSGTFHVKLP------------KKHNVELGITISSPSSRKPGD-PLVISDIKKG 556
             +S   +S    V +             +K +  LG ++        GD PL I+ I KG
Sbjct: 1210 TDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKG 1269

Query: 557  SVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCED-LVKLKIRKDEDNSDEQESS 615
            + + ++ T++ GD++L +    +   +  +A  I++   D  V + IR+    S E  ++
Sbjct: 1270 AASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAA 1329

Query: 616  G 616
            G
Sbjct: 1330 G 1330



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 42/153 (27%), Positives = 73/153 (47%), Gaps = 10/153 (6%)

Query: 580  DNCSMEDAVQILQ--QCEDLVKL-KIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITIS 636
            D+ S++    ++     E+L KL +  K  D +  ++  G I  T+  K  G  LG +++
Sbjct: 1071 DHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDG-IHVTILHKEEGAGLGFSLA 1129

Query: 637  GTEEPFDPII-ISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGE-- 693
            G  +  + +I +  +   GLA + G I  G+ +L+IN  SLKG    +A+ +L+ A E  
Sbjct: 1130 GGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPR 1189

Query: 694  ---TVTLKIKKQTDAQSASSPKKFPISSHLSDL 723
                VT K+  +      SS      +S  SD+
Sbjct: 1190 QAVIVTRKLTPEAMPDLNSSTDSAASASAASDV 1222



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 38/148 (25%), Positives = 69/148 (46%), Gaps = 5/148 (3%)

Query: 228  QEAALLIEYDVSVMD--SVATASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIKS 285
            +E   LIE +V V+D  ++    G  +  + K  GA LG +L        +VI + ++  
Sbjct: 1088 EELKKLIE-EVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFP 1146

Query: 286  ASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGP 345
              +A + G +  G+ +LSI+G S++  T  +A   L    +  +  I+    T  A+  P
Sbjct: 1147 NGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAM--P 1204

Query: 346  DHAALVSSSFSPTSMSAYSLSSLNMGTL 373
            D  +   S+ S ++ S  S+ S    T+
Sbjct: 1205 DLNSSTDSAASASAASDVSVESTAEATV 1232



 Score = 37.7 bits (86), Expect = 0.059
 Identities = 56/243 (23%), Positives = 93/243 (38%), Gaps = 44/243 (18%)

Query: 27  ASQTKPPDGALAVRRQSIPEEFKGSTVVE---LMKKEGTTLGLTVSGGIDKDGKP---RV 80
           A+ T  P  +L+  +   P     ++V+    LMK +   LG ++ GG D    P    V
Sbjct: 187 AAGTSRPTRSLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYV 246

Query: 81  SNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVV-LEVEYEL--- 136
             +  GG AA   +L  GD I  +NG ++A   H + +   K   + ++ L V   L   
Sbjct: 247 KTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAP 306

Query: 137 --------PPV--SVQGSSVIFR-----------------------TVEVTLHKEGNTFG 163
                   PP+  S+  S+ I +                        VEV+L KE    G
Sbjct: 307 PSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGV-G 365

Query: 164 FVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSIL 223
             I   +         + +  + PG  A  +G ++ GD ++ +    +   T  E  +IL
Sbjct: 366 LGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTIL 425

Query: 224 KQC 226
             C
Sbjct: 426 SHC 428



 Score = 35.4 bits (80), Expect = 0.29
 Identities = 32/115 (27%), Positives = 54/115 (46%), Gaps = 5/115 (4%)

Query: 622 VELKRYGGPLGITISGTEEP-FDPI--IISSLTKGGLAERTGAIHIGDRILAINSSSLKG 678
           V +K     LG +I G ++  + PI   + ++  GG A   G +  GD IL +N  S+ G
Sbjct: 218 VLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAG 277

Query: 679 KPLSEAIHLLQMAGE-TVTLKIK-KQTDAQSASSPKKFPISSHLSDLGDVEEDSS 731
               +A+   + A +  +TL ++ + T   S  S    P+   LS    + +DSS
Sbjct: 278 LTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSS 332


>gi|27262655 interleukin 16 isoform 1 precursor [Homo sapiens]
          Length = 631

 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 84/322 (26%), Positives = 140/322 (43%), Gaps = 46/322 (14%)

Query: 33  PDGALAVRRQSIPEEFKGSTVVELMKKEGTTLGLTVSGGIDKDGKPRVSNLRQ---GGIA 89
           P      +   IP+E  G++      ++    G   +  +D      +S LR+   G   
Sbjct: 305 PSSISCAQTPCIPKE--GASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGLTE 362

Query: 90  ARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFR 149
           A+ D  D GD+    +G          +ISLL +   + ++E    L   +++    I  
Sbjct: 363 AKED--DDGDHSSLQSG--------QSVISLLSSEELKKLIEEVKVLDEATLKQLDGIHV 412

Query: 150 TVEVTLHKE-GNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDG 208
           T+   LHKE G   GF + GGA D  NK   + +  V P G A +EGTI+ G+ +LS++G
Sbjct: 413 TI---LHKEEGAGLGFSLAGGA-DLENKV--ITVHRVFPNGLASQEGTIQKGNEVLSING 466

Query: 209 IRLLGTTHAEAMSILKQCGQ-EAALLIEYDV---------SVMDSVATASGPLLVEVAKT 258
             L GTTH +A++IL+Q  +   A+++   +         S  DS A+AS    V V  T
Sbjct: 467 KSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVEST 526

Query: 259 PGASLGVALTTSMCC--------------NKQVIVIDKIKSASIADRCGALHVGDHILSI 304
             A++       M                  + + I++I   + +++   +  GD IL +
Sbjct: 527 AEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQL 586

Query: 305 DGTSMEYCTLAEATQFLANTTD 326
            GT+M+  T  EA   +    D
Sbjct: 587 GGTAMQGLTRFEAWNIIKALPD 608



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 57/227 (25%), Positives = 102/227 (44%), Gaps = 25/227 (11%)

Query: 46  EEFKGSTVVELMKKEGTTLGLTVSGGIDKDGKP-RVSNLRQGGIAARSDQLDVGDYIKAV 104
           ++  G  V  L K+EG  LG +++GG D + K   V  +   G+A++   +  G+ + ++
Sbjct: 405 KQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSI 464

Query: 105 NGINLAKFRHDEIISLLKNVGE-RVVLEVEYELPP---------------------VSVQ 142
           NG +L    H + +++L+   E R  + V  +L P                     VSV+
Sbjct: 465 NGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVE 524

Query: 143 GSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDR 202
            S+       VTL K     GF + GG     +  +P+ I  +  G  +++  T++PGD 
Sbjct: 525 -STAEATVCTVTLEKMSAGLGFSLEGGK-GSLHGDKPLTINRIFKGAASEQSETVQPGDE 582

Query: 203 LLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASG 249
           +L + G  + G T  EA +I+K        ++    S+     TA+G
Sbjct: 583 ILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAG 629



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 49/244 (20%), Positives = 111/244 (45%), Gaps = 37/244 (15%)

Query: 486 EEASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITISSPSSRKPG 545
           EE  +L+ +  +  + TL+             G     L K+    LG +++  +  +  
Sbjct: 387 EELKKLIEEVKVLDEATLK----------QLDGIHVTILHKEEGAGLGFSLAGGADLE-N 435

Query: 546 DPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCED-----LVKL 600
             + +  +    +A + GT++ G+++L+I+   L   +  DA+ IL+Q  +     +V  
Sbjct: 436 KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTR 495

Query: 601 KIRK----DEDNSDEQESSG-------------AIIYTVELKRYGGPLGITISGTEEPFD 643
           K+      D ++S +  +S              A + TV L++    LG ++ G +    
Sbjct: 496 KLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLH 555

Query: 644 ---PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQ-MAGETVTLKI 699
              P+ I+ + KG  +E++  +  GD IL +  ++++G    EA ++++ +    VT+ I
Sbjct: 556 GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVI 615

Query: 700 KKQT 703
           ++++
Sbjct: 616 RRKS 619



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 44/181 (24%), Positives = 83/181 (45%), Gaps = 24/181 (13%)

Query: 460 AERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSS-------ITSKVTLEIEFDV--- 509
           A + G +Q G+ V++ING   + +T  +A  +LR +        +T K+T E   D+   
Sbjct: 449 ASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSS 508

Query: 510 AESVIPSSGTFHVKLP------------KKHNVELGITISSPSSRKPGD-PLVISDIKKG 556
            +S   +S    V +             +K +  LG ++        GD PL I+ I KG
Sbjct: 509 TDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKG 568

Query: 557 SVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCED-LVKLKIRKDEDNSDEQESS 615
           + + ++ T++ GD++L +    +   +  +A  I++   D  V + IR+    S E  ++
Sbjct: 569 AASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAA 628

Query: 616 G 616
           G
Sbjct: 629 G 629



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 42/153 (27%), Positives = 73/153 (47%), Gaps = 10/153 (6%)

Query: 580 DNCSMEDAVQILQ--QCEDLVKL-KIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITIS 636
           D+ S++    ++     E+L KL +  K  D +  ++  G I  T+  K  G  LG +++
Sbjct: 370 DHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDG-IHVTILHKEEGAGLGFSLA 428

Query: 637 GTEEPFDPII-ISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGE-- 693
           G  +  + +I +  +   GLA + G I  G+ +L+IN  SLKG    +A+ +L+ A E  
Sbjct: 429 GGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPR 488

Query: 694 ---TVTLKIKKQTDAQSASSPKKFPISSHLSDL 723
               VT K+  +      SS      +S  SD+
Sbjct: 489 QAVIVTRKLTPEAMPDLNSSTDSAASASAASDV 521



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 38/148 (25%), Positives = 69/148 (46%), Gaps = 5/148 (3%)

Query: 228 QEAALLIEYDVSVMD--SVATASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIKS 285
           +E   LIE +V V+D  ++    G  +  + K  GA LG +L        +VI + ++  
Sbjct: 387 EELKKLIE-EVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFP 445

Query: 286 ASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGP 345
             +A + G +  G+ +LSI+G S++  T  +A   L    +  +  I+    T  A+  P
Sbjct: 446 NGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAM--P 503

Query: 346 DHAALVSSSFSPTSMSAYSLSSLNMGTL 373
           D  +   S+ S ++ S  S+ S    T+
Sbjct: 504 DLNSSTDSAASASAASDVSVESTAEATV 531


>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
            isoform 3 [Homo sapiens]
          Length = 2294

 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 179/814 (21%), Positives = 299/814 (36%), Gaps = 126/814 (15%)

Query: 278  IVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEIL-PHH 336
            I I  +     AD  G L  GD ++S++  S+E  +   A + L N  + V L I  P  
Sbjct: 930  IFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKE 989

Query: 337  QTRLALKGPDHAALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDF 396
            +       P H  L +   +    S+Y   S    +     +S   RGT+  R + +  F
Sbjct: 990  KISKVPSTPVH--LTNEMKNYMKKSSYMQDSAIDSSSKDHHWS---RGTL--RHISENSF 1042

Query: 397  KSSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEA 456
              S  L   +  L+ Q   TE+    L+   V GF     G     E+    P  S I  
Sbjct: 1043 GPSGGLREGS--LSSQDSRTESAS--LSQSQVNGFFASHLGDQTWQESQHGSPSPSVISK 1098

Query: 457  -----------DSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQ----LLRDSSITSKV 501
                        S  ++ G+  + D   +  G    D     +SQ      ++SS +   
Sbjct: 1099 ATEKETFTDSNQSKTKKPGISDVTD--YSDRGDSDMDEATYSSSQDHQTPKQESSSSVNT 1156

Query: 502  TLEIEFDVAESVIPSSGT-FHVKLPKKHNVELGITISSP--SSRKPGDPLVISDIKKGSV 558
            + ++ F    S  P  G  F V+L K  N  LGI+++    +S + G   V + I +G+ 
Sbjct: 1157 SNKMNFKTFSSSPPKPGDIFEVELAKNDN-SLGISVTGGVNTSVRHGGIYVKAVIPQGA- 1214

Query: 559  AHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDE------------ 606
            A   G +  GD++LA++ + L+  + + AV+ L+    +V L + K +            
Sbjct: 1215 AESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTP 1274

Query: 607  -----DNSDEQESSGAIIYTVELKRY----------------GGPLGITISGTEEPFDPI 645
                 D + + +    +  T ++K Y                   LG + S  +      
Sbjct: 1275 QCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQ 1334

Query: 646  IISSLTK------GGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKI 699
            I +S+ +      G  A  +G I +GD IL +N +SLKG    E I  L+     V L +
Sbjct: 1335 INASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLL 1394

Query: 700  KKQTDAQSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDMYPSTVPSVDSAVDSWDG 759
             +                                  PG L ++  + +  + S       
Sbjct: 1395 CR--------------------------------PPPGVLPEIDTALLTPLQSPAQVLPN 1422

Query: 760  SAIDTSYGTQGTSFQASGYNFNTYDWRSPKQRGSLSPVTKPRSQTYPDVGLSYEDWDRST 819
            S+ D+S        Q++  + N    +S KQ  S S     R  +Y D   S ED D  T
Sbjct: 1423 SSKDSS--QPSCVEQSTSSDENEMSDKSKKQCKSPS-----RRDSYSDSSGSGED-DLVT 1474

Query: 820  ASGFAGAADSAETEQEENFWSQALEDLETCGQSGILRELEEKADRRVSLRNMTLL-ATIM 878
            A   A  ++S         WS AL    +   S      E    +  ++  M      I 
Sbjct: 1475 AP--ANISNST--------WSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIP 1524

Query: 879  SGSTMSLNHEAPTPRSQLGRQASFQERSSSRPHYSQTTRSNTLPSDVGRKSVTLRKMKQE 938
            +      ++ +P P      Q S+Q +S S    S         S+  R+      +K +
Sbjct: 1525 NKPEFEDSNPSPLPPDMAPGQ-SYQPQSESASSSSMDKYHIHHISEPTRQE-NWTPLKND 1582

Query: 939  IKEIMSPTPVELHKVTLYKDSDMEDFGFSVADGLLEKGVYVKNIRPAGPGDLGGLKPYDR 998
            ++  +    +E+  +     S+    GF+V  G    G YV ++        G LKP DR
Sbjct: 1583 LENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDR 1642

Query: 999  LLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISR 1032
            L++VN     +      V L+  +   + LVI R
Sbjct: 1643 LIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR 1676



 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 109/487 (22%), Positives = 188/487 (38%), Gaps = 73/487 (14%)

Query: 163  GFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSI 222
            GF I GG    R     + I+ V PGGPAD +G +KPGDRL+SV+ + L G +H  A+ I
Sbjct: 914  GFQIIGGEKMGR-LDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEI 972

Query: 223  LKQCGQEAALLIEYDVSVMDSVATASGPLLVEV---AKTPGASLGVALTTSMCCNKQVIV 279
            L+   ++  L+I      +  V +    L  E+    K        A+ +S   +     
Sbjct: 973  LQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRG 1032

Query: 280  IDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQ---FLANTTDQVKLEILPHH 336
              +  S +     G L  G   LS   +  E  +L+++     F ++  DQ   E     
Sbjct: 1033 TLRHISENSFGPSGGLREGS--LSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGS 1090

Query: 337  QTRLAL-KGPDHAALVSSSFSPTSMSAYS----LSSLNMGTLPRSLYSTSPRGTMMRRRL 391
             +   + K  +      S+ S T     S     S      +  + YS+S        + 
Sbjct: 1091 PSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSS-----QDHQT 1145

Query: 392  KKKDFKSSLSLA--------SSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATE 443
             K++  SS++ +        SS+    G +   E       A      GI + G V  T 
Sbjct: 1146 PKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVE------LAKNDNSLGISVTGGV-NTS 1198

Query: 444  TLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSS------- 496
                   +  +     AE  G +  GDRV+A+NG+  E +T ++A + LR++        
Sbjct: 1199 VRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLL 1258

Query: 497  -------------ITSKVTLEIEFDVAE--------------SVIPSSGTFHVKLPKKHN 529
                         +T + TL  +    +              S +    TF VKL  K++
Sbjct: 1259 EKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKL-FKNS 1317

Query: 530  VELGITISSPSSRKP----GDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSME 585
              LG + S   +  P       + +  +  G  A  +G +++GD +L ++   L   S +
Sbjct: 1318 SGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQ 1377

Query: 586  DAVQILQ 592
            + +  L+
Sbjct: 1378 EVISALR 1384



 Score = 63.9 bits (154), Expect = 8e-10
 Identities = 114/490 (23%), Positives = 185/490 (37%), Gaps = 95/490 (19%)

Query: 587  AVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKR---YGGPLGITISGTEEPFD 643
            A Q  Q  +D+  L  R    +S E+E     I  V LK+   YG  LG  I G E+   
Sbjct: 873  ARQSNQDAQDIDVLHKRWSIVSSPERE-----ITLVNLKKDAKYG--LGFQIIGGEKMGR 925

Query: 644  ---PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIK 700
                I ISS+  GG A+  G +  GDR++++NS SL+G     AI +LQ A E VTL I 
Sbjct: 926  LDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVI- 984

Query: 701  KQTDAQSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDMYPSTVPSVDSAVDSWDGS 760
                +Q      K P              S+P     ++ +    +    DSA+D    S
Sbjct: 985  ----SQPKEKISKVP--------------STPVHLTNEMKNYMKKSSYMQDSAID----S 1022

Query: 761  AIDTSYGTQGTSFQASGYNFNTYDWRSPKQRGSLSPVTKPRSQTYPDVGLSYEDWDRSTA 820
            +    + ++GT    S    N++      + GSLS           D         +S  
Sbjct: 1023 SSKDHHWSRGTLRHISE---NSFGPSGGLREGSLSS---------QDSRTESASLSQSQV 1070

Query: 821  SGFAGAADSAETEQEENFWSQALEDLETCGQSGILRELEEKADRRVSLRNMTLLATIMSG 880
            +GF  +    +T QE    S +           ++ +  EK                   
Sbjct: 1071 NGFFASHLGDQTWQESQHGSPS---------PSVISKATEK------------------- 1102

Query: 881  STMSLNHEAPTPRSQLGRQASFQERSSS---RPHYSQTTRSNTLPSDVGRKSVTLRKMKQ 937
             T + ++++ T +  +     + +R  S      YS +    T   +      T  KM  
Sbjct: 1103 ETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNF 1162

Query: 938  EIKEIMSPTPVELHKVTLYKDSDMEDFGFSVADG----LLEKGVYVKNIRPAGPGDLGG- 992
            +      P P ++ +V L K+ +    G SV  G    +   G+YVK + P G  +  G 
Sbjct: 1163 KTFSSSPPKPGDIFEVELAKNDN--SLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGR 1220

Query: 993  LKPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISRN---------PLASQKSIDQ 1043
            +   DR+L VN V          V  +  +G  + L++ +          P+  Q ++  
Sbjct: 1221 IHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSD 1280

Query: 1044 QSLPGDWSEQ 1053
            Q+  G   E+
Sbjct: 1281 QNAQGQGPEK 1290



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 70/272 (25%), Positives = 107/272 (39%), Gaps = 66/272 (24%)

Query: 19   DESPYTKSASQTKPPDGALAVRRQSIPEEFK---------GSTVVELMKKEGTTLGLTVS 69
            DE+ Y+ S     P   + +    S    FK         G      + K   +LG++V+
Sbjct: 1133 DEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVT 1192

Query: 70   GGIDKDGKPRVSNLRQGGI---------AARSD-QLDVGDYIKAVNGINLAKFRHDEIIS 119
            GG++       +++R GGI         AA SD ++  GD + AVNG++L    H + + 
Sbjct: 1193 GGVN-------TSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVE 1245

Query: 120  LLKNVGERVVLEVEYELPPVSV------------------QGSSVIFRTV---------- 151
             L+N G+ V L +E    P S                   QG   + +T           
Sbjct: 1246 TLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTE 1305

Query: 152  ----EVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVR-----PGGPADREGTIKPGDR 202
                EV L K  +  GF     + +D      +  + VR     PG PA   G I  GD 
Sbjct: 1306 ENTFEVKLFKNSSGLGFSF---SREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDV 1362

Query: 203  LLSVDGIRLLGTTHAEAMSILKQCGQEAALLI 234
            +L V+G  L G +  E +S L+    E  LL+
Sbjct: 1363 ILKVNGASLKGLSQQEVISALRGTAPEVFLLL 1394



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 57/219 (26%), Positives = 88/219 (40%), Gaps = 43/219 (19%)

Query: 152  EVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRL 211
            EV L K  N+ G  + GG +        + +  V P G A+ +G I  GDR+L+V+G+ L
Sbjct: 1177 EVELAKNDNSLGISVTGGVNTSVRHGG-IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSL 1235

Query: 212  LGTTHAEAMSILKQCGQEAALLIEYDVS--------------VMDSVATASGPLLVEVAK 257
             G TH +A+  L+  GQ   LL+E   S              + D  A   GP   +V K
Sbjct: 1236 EGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGP--EKVKK 1293

Query: 258  TP---------------------GASLGVALTTS-----MCCNKQVIVIDKIKSASIADR 291
            T                       + LG + +          N  ++ + K+     A  
Sbjct: 1294 TTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAE 1353

Query: 292  CGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKL 330
             G + VGD IL ++G S++  +  E    L  T  +V L
Sbjct: 1354 SGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFL 1392



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 52/194 (26%), Positives = 87/194 (44%), Gaps = 9/194 (4%)

Query: 190  PADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASG 249
            PA  +G +KPGDRL+ V+   +   TH +A+++L+   +   L+I     V++       
Sbjct: 1630 PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIG---RVLELPRIPML 1686

Query: 250  P-LLVEVAKTPG-ASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGT 307
            P LL ++  T     LG +L        QV+ I  I   S+A   G L + D I  ++G 
Sbjct: 1687 PHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGV 1746

Query: 308  SMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHAALVSSSFSPTSMSAYSLSS 367
            S +  TL E  + L  +   +   +L   +  L +      + VS+  S     +YS+ S
Sbjct: 1747 STQGMTLEEVNRALDMSLPSL---VLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGS 1803

Query: 368  LNMGTL-PRSLYST 380
             +   L P   +ST
Sbjct: 1804 CSQPALTPNDSFST 1817



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 103/518 (19%), Positives = 188/518 (36%), Gaps = 64/518 (12%)

Query: 548  LVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDED 607
            + IS +  G  A   G L+ GD+L++++++ L+  S   A++ILQ   + V L I + ++
Sbjct: 930  IFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKE 989

Query: 608  NSDEQESSGAIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDR 667
               +  S+  +  T E+K Y                   I S +K     R    HI + 
Sbjct: 990  KISKVPST-PVHLTNEMKNY--------MKKSSYMQDSAIDSSSKDHHWSRGTLRHISEN 1040

Query: 668  ILAINS-------SSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQSASSPKKFPISSHL 720
                +        SS   +  S ++   Q+ G   +    +        SP    IS   
Sbjct: 1041 SFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKAT 1100

Query: 721  SDLGDVEEDSSPAQKPGKLSDMYPSTVPSVDSAVDSWDGSAIDTSYGTQGTSFQASGYNF 780
                  + + S  +KPG +SD+                     T Y  +G S        
Sbjct: 1101 EKETFTDSNQSKTKKPG-ISDV---------------------TDYSDRGDSDMDEATYS 1138

Query: 781  NTYDWRSPKQRGSLSPVT------KPRSQTYPDVGLSYE----DWDRSTASGFAGAADSA 830
            ++ D ++PKQ  S S  T      K  S + P  G  +E      D S      G  +++
Sbjct: 1139 SSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTS 1198

Query: 831  ETEQEENFWSQALEDLETCGQSGILRELEEKADRRVSLRNMTLLATIMSGSTMSLNHEAP 890
               +    + +A+         G +     K DR +++  ++L       +  +L +   
Sbjct: 1199 V--RHGGIYVKAVIPQGAAESDGRIH----KGDRVLAVNGVSLEGATHKQAVETLRNTGQ 1252

Query: 891  TPRSQLGRQASFQERSSSRPHYSQTTRSNTLPSDVGRKSVTLRKMKQEIKEIMSPTPVEL 950
                 L +  S     +S+ H   T +      +   +     K   ++K+    T    
Sbjct: 1253 VVHLLLEKGQS----PTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENT 1308

Query: 951  HKVTLYKDSDMEDFGFSVADGLLEKG-----VYVKNIRPAGP-GDLGGLKPYDRLLQVNH 1004
             +V L+K+S    F FS  D L+ +      V VK + P  P  + G +   D +L+VN 
Sbjct: 1309 FEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNG 1368

Query: 1005 VRTRDFDCCLVVPLIAESGNKLDLVISRNPLASQKSID 1042
               +      V+  +  +  ++ L++ R P      ID
Sbjct: 1369 ASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEID 1406



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 51/220 (23%), Positives = 93/220 (42%), Gaps = 11/220 (5%)

Query: 522  VKLPKKHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDN 581
            + L K     LG T++  + R       + D+ +   A   G L+ GD+L+ +++  + N
Sbjct: 1598 ITLIKSEKGSLGFTVTKGNQRIG---CYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTN 1653

Query: 582  CSMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEP 641
             +  DAV +L+     V+L I +  +          ++  + L      LG ++ G  + 
Sbjct: 1654 MTHTDAVNLLRAASKTVRLVIGRVLE-LPRIPMLPHLLPDITLTCNKEELGFSLCGGHDS 1712

Query: 642  -FDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIK 700
             +  + IS +    +A   G + + D I  +N  S +G  L E    L M+  ++ LK  
Sbjct: 1713 LYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKAT 1772

Query: 701  KQTDAQSASSPKKFPISSHLSDLGD----VEEDSSPAQKP 736
            +  D     S K+  +S+  S  G+    V   S PA  P
Sbjct: 1773 R-NDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTP 1811



 Score = 38.1 bits (87), Expect = 0.045
 Identities = 31/115 (26%), Positives = 54/115 (46%), Gaps = 5/115 (4%)

Query: 52   TVVELMKKEGTTLGLTVSGGIDKDGKPR----VSNLRQGGIAARSDQLDVGDYIKAVNGI 107
            T+V L K     LG  + GG +K G+      +S++  GG A     L  GD + +VN +
Sbjct: 901  TLVNLKKDAKYGLGFQIIGG-EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSV 959

Query: 108  NLAKFRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKEGNTF 162
            +L    H   I +L+N  E V L +      +S   S+ +  T E+  + + +++
Sbjct: 960  SLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSY 1014



 Score = 35.4 bits (80), Expect = 0.29
 Identities = 33/98 (33%), Positives = 45/98 (45%), Gaps = 5/98 (5%)

Query: 451  ISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVA 510
            IS I   S A   G LQ+ D +  +NG+ T+  T EE ++ L D S+ S V      D+ 
Sbjct: 1719 ISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRAL-DMSLPSLVLKATRNDL- 1776

Query: 511  ESVIPSSGTFHVKLPK--KHNVELGITISSPSSRKPGD 546
              V+PSS    V  PK  K N    +   S  +  P D
Sbjct: 1777 -PVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPND 1813


>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
            isoform 1 [Homo sapiens]
          Length = 2485

 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 179/814 (21%), Positives = 299/814 (36%), Gaps = 126/814 (15%)

Query: 278  IVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEIL-PHH 336
            I I  +     AD  G L  GD ++S++  S+E  +   A + L N  + V L I  P  
Sbjct: 1121 IFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKE 1180

Query: 337  QTRLALKGPDHAALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDF 396
            +       P H  L +   +    S+Y   S    +     +S   RGT+  R + +  F
Sbjct: 1181 KISKVPSTPVH--LTNEMKNYMKKSSYMQDSAIDSSSKDHHWS---RGTL--RHISENSF 1233

Query: 397  KSSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEA 456
              S  L   +  L+ Q   TE+    L+   V GF     G     E+    P  S I  
Sbjct: 1234 GPSGGLREGS--LSSQDSRTESAS--LSQSQVNGFFASHLGDQTWQESQHGSPSPSVISK 1289

Query: 457  -----------DSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQ----LLRDSSITSKV 501
                        S  ++ G+  + D   +  G    D     +SQ      ++SS +   
Sbjct: 1290 ATEKETFTDSNQSKTKKPGISDVTD--YSDRGDSDMDEATYSSSQDHQTPKQESSSSVNT 1347

Query: 502  TLEIEFDVAESVIPSSGT-FHVKLPKKHNVELGITISSP--SSRKPGDPLVISDIKKGSV 558
            + ++ F    S  P  G  F V+L K  N  LGI+++    +S + G   V + I +G+ 
Sbjct: 1348 SNKMNFKTFSSSPPKPGDIFEVELAKNDN-SLGISVTGGVNTSVRHGGIYVKAVIPQGA- 1405

Query: 559  AHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDE------------ 606
            A   G +  GD++LA++ + L+  + + AV+ L+    +V L + K +            
Sbjct: 1406 AESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTP 1465

Query: 607  -----DNSDEQESSGAIIYTVELKRY----------------GGPLGITISGTEEPFDPI 645
                 D + + +    +  T ++K Y                   LG + S  +      
Sbjct: 1466 QCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQ 1525

Query: 646  IISSLTK------GGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKI 699
            I +S+ +      G  A  +G I +GD IL +N +SLKG    E I  L+     V L +
Sbjct: 1526 INASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLL 1585

Query: 700  KKQTDAQSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDMYPSTVPSVDSAVDSWDG 759
             +                                  PG L ++  + +  + S       
Sbjct: 1586 CR--------------------------------PPPGVLPEIDTALLTPLQSPAQVLPN 1613

Query: 760  SAIDTSYGTQGTSFQASGYNFNTYDWRSPKQRGSLSPVTKPRSQTYPDVGLSYEDWDRST 819
            S+ D+S        Q++  + N    +S KQ  S S     R  +Y D   S ED D  T
Sbjct: 1614 SSKDSS--QPSCVEQSTSSDENEMSDKSKKQCKSPS-----RRDSYSDSSGSGED-DLVT 1665

Query: 820  ASGFAGAADSAETEQEENFWSQALEDLETCGQSGILRELEEKADRRVSLRNMTLL-ATIM 878
            A   A  ++S         WS AL    +   S      E    +  ++  M      I 
Sbjct: 1666 AP--ANISNST--------WSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIP 1715

Query: 879  SGSTMSLNHEAPTPRSQLGRQASFQERSSSRPHYSQTTRSNTLPSDVGRKSVTLRKMKQE 938
            +      ++ +P P      Q S+Q +S S    S         S+  R+      +K +
Sbjct: 1716 NKPEFEDSNPSPLPPDMAPGQ-SYQPQSESASSSSMDKYHIHHISEPTRQE-NWTPLKND 1773

Query: 939  IKEIMSPTPVELHKVTLYKDSDMEDFGFSVADGLLEKGVYVKNIRPAGPGDLGGLKPYDR 998
            ++  +    +E+  +     S+    GF+V  G    G YV ++        G LKP DR
Sbjct: 1774 LENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDR 1833

Query: 999  LLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISR 1032
            L++VN     +      V L+  +   + LVI R
Sbjct: 1834 LIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR 1867



 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 109/487 (22%), Positives = 188/487 (38%), Gaps = 73/487 (14%)

Query: 163  GFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSI 222
            GF I GG    R     + I+ V PGGPAD +G +KPGDRL+SV+ + L G +H  A+ I
Sbjct: 1105 GFQIIGGEKMGR-LDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEI 1163

Query: 223  LKQCGQEAALLIEYDVSVMDSVATASGPLLVEV---AKTPGASLGVALTTSMCCNKQVIV 279
            L+   ++  L+I      +  V +    L  E+    K        A+ +S   +     
Sbjct: 1164 LQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRG 1223

Query: 280  IDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQ---FLANTTDQVKLEILPHH 336
              +  S +     G L  G   LS   +  E  +L+++     F ++  DQ   E     
Sbjct: 1224 TLRHISENSFGPSGGLREGS--LSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGS 1281

Query: 337  QTRLAL-KGPDHAALVSSSFSPTSMSAYS----LSSLNMGTLPRSLYSTSPRGTMMRRRL 391
             +   + K  +      S+ S T     S     S      +  + YS+S        + 
Sbjct: 1282 PSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSS-----QDHQT 1336

Query: 392  KKKDFKSSLSLA--------SSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATE 443
             K++  SS++ +        SS+    G +   E       A      GI + G V  T 
Sbjct: 1337 PKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVE------LAKNDNSLGISVTGGV-NTS 1389

Query: 444  TLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSS------- 496
                   +  +     AE  G +  GDRV+A+NG+  E +T ++A + LR++        
Sbjct: 1390 VRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLL 1449

Query: 497  -------------ITSKVTLEIEFDVAE--------------SVIPSSGTFHVKLPKKHN 529
                         +T + TL  +    +              S +    TF VKL  K++
Sbjct: 1450 EKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKL-FKNS 1508

Query: 530  VELGITISSPSSRKP----GDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSME 585
              LG + S   +  P       + +  +  G  A  +G +++GD +L ++   L   S +
Sbjct: 1509 SGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQ 1568

Query: 586  DAVQILQ 592
            + +  L+
Sbjct: 1569 EVISALR 1575



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 70/272 (25%), Positives = 107/272 (39%), Gaps = 66/272 (24%)

Query: 19   DESPYTKSASQTKPPDGALAVRRQSIPEEFK---------GSTVVELMKKEGTTLGLTVS 69
            DE+ Y+ S     P   + +    S    FK         G      + K   +LG++V+
Sbjct: 1324 DEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVT 1383

Query: 70   GGIDKDGKPRVSNLRQGGI---------AARSD-QLDVGDYIKAVNGINLAKFRHDEIIS 119
            GG++       +++R GGI         AA SD ++  GD + AVNG++L    H + + 
Sbjct: 1384 GGVN-------TSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVE 1436

Query: 120  LLKNVGERVVLEVEYELPPVSV------------------QGSSVIFRTV---------- 151
             L+N G+ V L +E    P S                   QG   + +T           
Sbjct: 1437 TLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTE 1496

Query: 152  ----EVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVR-----PGGPADREGTIKPGDR 202
                EV L K  +  GF     + +D      +  + VR     PG PA   G I  GD 
Sbjct: 1497 ENTFEVKLFKNSSGLGFSF---SREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDV 1553

Query: 203  LLSVDGIRLLGTTHAEAMSILKQCGQEAALLI 234
            +L V+G  L G +  E +S L+    E  LL+
Sbjct: 1554 ILKVNGASLKGLSQQEVISALRGTAPEVFLLL 1585



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 57/219 (26%), Positives = 88/219 (40%), Gaps = 43/219 (19%)

Query: 152  EVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRL 211
            EV L K  N+ G  + GG +        + +  V P G A+ +G I  GDR+L+V+G+ L
Sbjct: 1368 EVELAKNDNSLGISVTGGVNTSVRHGG-IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSL 1426

Query: 212  LGTTHAEAMSILKQCGQEAALLIEYDVS--------------VMDSVATASGPLLVEVAK 257
             G TH +A+  L+  GQ   LL+E   S              + D  A   GP   +V K
Sbjct: 1427 EGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGP--EKVKK 1484

Query: 258  TP---------------------GASLGVALTTS-----MCCNKQVIVIDKIKSASIADR 291
            T                       + LG + +          N  ++ + K+     A  
Sbjct: 1485 TTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAE 1544

Query: 292  CGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKL 330
             G + VGD IL ++G S++  +  E    L  T  +V L
Sbjct: 1545 SGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFL 1583



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 94/426 (22%), Positives = 159/426 (37%), Gaps = 82/426 (19%)

Query: 645  IIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTD 704
            I ISS+  GG A+  G +  GDR++++NS SL+G     AI +LQ A E VTL I     
Sbjct: 1121 IFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVI----- 1175

Query: 705  AQSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDMYPSTVPSVDSAVDSWDGSAIDT 764
            +Q      K P              S+P     ++ +    +    DSA+D    S+   
Sbjct: 1176 SQPKEKISKVP--------------STPVHLTNEMKNYMKKSSYMQDSAID----SSSKD 1217

Query: 765  SYGTQGTSFQASGYNFNTYDWRSPKQRGSLSPVTKPRSQTYPDVGLSYEDWDRSTASGFA 824
             + ++GT    S    N++      + GSLS           D         +S  +GF 
Sbjct: 1218 HHWSRGTLRHISE---NSFGPSGGLREGSLSS---------QDSRTESASLSQSQVNGFF 1265

Query: 825  GAADSAETEQEENFWSQALEDLETCGQSGILRELEEKADRRVSLRNMTLLATIMSGSTMS 884
             +    +T QE    S +           ++ +  EK                    T +
Sbjct: 1266 ASHLGDQTWQESQHGSPS---------PSVISKATEK-------------------ETFT 1297

Query: 885  LNHEAPTPRSQLGRQASFQERSSS---RPHYSQTTRSNTLPSDVGRKSVTLRKMKQEIKE 941
             ++++ T +  +     + +R  S      YS +    T   +      T  KM  +   
Sbjct: 1298 DSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFS 1357

Query: 942  IMSPTPVELHKVTLYKDSDMEDFGFSVADG----LLEKGVYVKNIRPAGPGDLGG-LKPY 996
               P P ++ +V L K+ +    G SV  G    +   G+YVK + P G  +  G +   
Sbjct: 1358 SSPPKPGDIFEVELAKNDN--SLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKG 1415

Query: 997  DRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISRN---------PLASQKSIDQQSLP 1047
            DR+L VN V          V  +  +G  + L++ +          P+  Q ++  Q+  
Sbjct: 1416 DRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQ 1475

Query: 1048 GDWSEQ 1053
            G   E+
Sbjct: 1476 GQGPEK 1481



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 52/194 (26%), Positives = 87/194 (44%), Gaps = 9/194 (4%)

Query: 190  PADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASG 249
            PA  +G +KPGDRL+ V+   +   TH +A+++L+   +   L+I     V++       
Sbjct: 1821 PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIG---RVLELPRIPML 1877

Query: 250  P-LLVEVAKTPG-ASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGT 307
            P LL ++  T     LG +L        QV+ I  I   S+A   G L + D I  ++G 
Sbjct: 1878 PHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGV 1937

Query: 308  SMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHAALVSSSFSPTSMSAYSLSS 367
            S +  TL E  + L  +   +   +L   +  L +      + VS+  S     +YS+ S
Sbjct: 1938 STQGMTLEEVNRALDMSLPSL---VLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGS 1994

Query: 368  LNMGTL-PRSLYST 380
             +   L P   +ST
Sbjct: 1995 CSQPALTPNDSFST 2008



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 103/518 (19%), Positives = 188/518 (36%), Gaps = 64/518 (12%)

Query: 548  LVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDED 607
            + IS +  G  A   G L+ GD+L++++++ L+  S   A++ILQ   + V L I + ++
Sbjct: 1121 IFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKE 1180

Query: 608  NSDEQESSGAIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDR 667
               +  S+  +  T E+K Y                   I S +K     R    HI + 
Sbjct: 1181 KISKVPST-PVHLTNEMKNY--------MKKSSYMQDSAIDSSSKDHHWSRGTLRHISEN 1231

Query: 668  ILAINS-------SSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQSASSPKKFPISSHL 720
                +        SS   +  S ++   Q+ G   +    +        SP    IS   
Sbjct: 1232 SFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKAT 1291

Query: 721  SDLGDVEEDSSPAQKPGKLSDMYPSTVPSVDSAVDSWDGSAIDTSYGTQGTSFQASGYNF 780
                  + + S  +KPG +SD+                     T Y  +G S        
Sbjct: 1292 EKETFTDSNQSKTKKPG-ISDV---------------------TDYSDRGDSDMDEATYS 1329

Query: 781  NTYDWRSPKQRGSLSPVT------KPRSQTYPDVGLSYE----DWDRSTASGFAGAADSA 830
            ++ D ++PKQ  S S  T      K  S + P  G  +E      D S      G  +++
Sbjct: 1330 SSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTS 1389

Query: 831  ETEQEENFWSQALEDLETCGQSGILRELEEKADRRVSLRNMTLLATIMSGSTMSLNHEAP 890
               +    + +A+         G +     K DR +++  ++L       +  +L +   
Sbjct: 1390 V--RHGGIYVKAVIPQGAAESDGRIH----KGDRVLAVNGVSLEGATHKQAVETLRNTGQ 1443

Query: 891  TPRSQLGRQASFQERSSSRPHYSQTTRSNTLPSDVGRKSVTLRKMKQEIKEIMSPTPVEL 950
                 L +  S     +S+ H   T +      +   +     K   ++K+    T    
Sbjct: 1444 VVHLLLEKGQS----PTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENT 1499

Query: 951  HKVTLYKDSDMEDFGFSVADGLLEKG-----VYVKNIRPAGP-GDLGGLKPYDRLLQVNH 1004
             +V L+K+S    F FS  D L+ +      V VK + P  P  + G +   D +L+VN 
Sbjct: 1500 FEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNG 1559

Query: 1005 VRTRDFDCCLVVPLIAESGNKLDLVISRNPLASQKSID 1042
               +      V+  +  +  ++ L++ R P      ID
Sbjct: 1560 ASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEID 1597



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 31/96 (32%), Positives = 48/96 (50%), Gaps = 6/96 (6%)

Query: 942  IMSPTPVELHKVTLYKDSDMEDFGFSVADG----LLEKGVYVKNIRPAGPGDLGG-LKPY 996
            I+S    E+  V L KD+     GF +  G     L+ G+++ ++ P GP DL G LKP 
Sbjct: 1083 IVSSPEREITLVNLKKDAKY-GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPG 1141

Query: 997  DRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISR 1032
            DRL+ VN V          + ++  +   + LVIS+
Sbjct: 1142 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQ 1177



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 51/220 (23%), Positives = 93/220 (42%), Gaps = 11/220 (5%)

Query: 522  VKLPKKHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDN 581
            + L K     LG T++  + R       + D+ +   A   G L+ GD+L+ +++  + N
Sbjct: 1789 ITLIKSEKGSLGFTVTKGNQRIG---CYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTN 1844

Query: 582  CSMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEP 641
             +  DAV +L+     V+L I +  +          ++  + L      LG ++ G  + 
Sbjct: 1845 MTHTDAVNLLRAASKTVRLVIGRVLE-LPRIPMLPHLLPDITLTCNKEELGFSLCGGHDS 1903

Query: 642  -FDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIK 700
             +  + IS +    +A   G + + D I  +N  S +G  L E    L M+  ++ LK  
Sbjct: 1904 LYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKAT 1963

Query: 701  KQTDAQSASSPKKFPISSHLSDLGD----VEEDSSPAQKP 736
            +  D     S K+  +S+  S  G+    V   S PA  P
Sbjct: 1964 R-NDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTP 2002



 Score = 38.9 bits (89), Expect = 0.026
 Identities = 39/144 (27%), Positives = 67/144 (46%), Gaps = 10/144 (6%)

Query: 26   SASQTKPPDGALAVRRQSI---PEEFKGSTVVELMKKEGTTLGLTVSGGIDKDGKPR--- 79
            S+SQ    +  +  +R SI   PE  +  T+V L K     LG  + GG +K G+     
Sbjct: 1065 SSSQVPLKENDVLHKRWSIVSSPE--REITLVNLKKDAKYGLGFQIIGG-EKMGRLDLGI 1121

Query: 80   -VSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEYELPP 138
             +S++  GG A     L  GD + +VN ++L    H   I +L+N  E V L +      
Sbjct: 1122 FISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEK 1181

Query: 139  VSVQGSSVIFRTVEVTLHKEGNTF 162
            +S   S+ +  T E+  + + +++
Sbjct: 1182 ISKVPSTPVHLTNEMKNYMKKSSY 1205



 Score = 35.4 bits (80), Expect = 0.29
 Identities = 33/98 (33%), Positives = 45/98 (45%), Gaps = 5/98 (5%)

Query: 451  ISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVA 510
            IS I   S A   G LQ+ D +  +NG+ T+  T EE ++ L D S+ S V      D+ 
Sbjct: 1910 ISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRAL-DMSLPSLVLKATRNDL- 1967

Query: 511  ESVIPSSGTFHVKLPK--KHNVELGITISSPSSRKPGD 546
              V+PSS    V  PK  K N    +   S  +  P D
Sbjct: 1968 -PVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPND 2004


>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
            2 [Homo sapiens]
          Length = 2466

 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 126/568 (22%), Positives = 220/568 (38%), Gaps = 84/568 (14%)

Query: 90   ARSDQLDVGDYIKAVNGINLAKF-------RHDEIISLLKNVGERVVLEVEYELPPVSVQ 142
            +RSD   +    K  N  ++A         +H+   S +++ G+  VL+V ++   +   
Sbjct: 1008 SRSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLDVLHKRWSIV-- 1065

Query: 143  GSSVIFRTVEVTLHKEGNT-FGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGD 201
             SS       V L K+     GF I GG    R     + I+ V PGGPAD +G +KPGD
Sbjct: 1066 -SSPEREITLVNLKKDAKYGLGFQIIGGEKMGR-LDLGIFISSVAPGGPADLDGCLKPGD 1123

Query: 202  RLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASGPLLVEV---AKT 258
            RL+SV+ + L G +H  A+ IL+   ++  L+I      +  V +    L  E+    K 
Sbjct: 1124 RLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKK 1183

Query: 259  PGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEAT 318
                   A+ +S   +       +  S +     G L  G   LS   +  E  +L+++ 
Sbjct: 1184 SSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGS--LSSQDSRTESASLSQSQ 1241

Query: 319  Q---FLANTTDQVKLEILPHHQTRLAL-KGPDHAALVSSSFSPTSMSAYS----LSSLNM 370
                F ++  DQ   E      +   + K  +      S+ S T     S     S    
Sbjct: 1242 VNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGD 1301

Query: 371  GTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLA--------SSTVGLAGQVVHTETTEVV 422
              +  + YS+S        +  K++  SS++ +        SS+    G +   E     
Sbjct: 1302 SDMDEATYSSS-----QDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVE----- 1351

Query: 423  LTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTED 482
              A      GI + G V  T        +  +     AE  G +  GDRV+A+NG+  E 
Sbjct: 1352 -LAKNDNSLGISVTGGV-NTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1409

Query: 483  STFEEASQLLRDSS--------------------ITSKVTLEIEFDVAE----------- 511
            +T ++A + LR++                     +T + TL  +    +           
Sbjct: 1410 ATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQV 1469

Query: 512  ---SVIPSSGTFHVKLPKKHNVELGITISSPSSRKP----GDPLVISDIKKGSVAHRTGT 564
               S +    TF VKL  K++  LG + S   +  P       + +  +  G  A  +G 
Sbjct: 1470 KDYSFVTEENTFEVKL-FKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGK 1528

Query: 565  LELGDKLLAIDNIRLDNCSMEDAVQILQ 592
            +++GD +L ++   L   S ++ +  L+
Sbjct: 1529 IDVGDVILKVNGASLKGLSQQEVISALR 1556



 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 179/814 (21%), Positives = 299/814 (36%), Gaps = 126/814 (15%)

Query: 278  IVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEIL-PHH 336
            I I  +     AD  G L  GD ++S++  S+E  +   A + L N  + V L I  P  
Sbjct: 1102 IFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKE 1161

Query: 337  QTRLALKGPDHAALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDF 396
            +       P H  L +   +    S+Y   S    +     +S   RGT+  R + +  F
Sbjct: 1162 KISKVPSTPVH--LTNEMKNYMKKSSYMQDSAIDSSSKDHHWS---RGTL--RHISENSF 1214

Query: 397  KSSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEA 456
              S  L   +  L+ Q   TE+    L+   V GF     G     E+    P  S I  
Sbjct: 1215 GPSGGLREGS--LSSQDSRTESAS--LSQSQVNGFFASHLGDQTWQESQHGSPSPSVISK 1270

Query: 457  -----------DSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQ----LLRDSSITSKV 501
                        S  ++ G+  + D   +  G    D     +SQ      ++SS +   
Sbjct: 1271 ATEKETFTDSNQSKTKKPGISDVTD--YSDRGDSDMDEATYSSSQDHQTPKQESSSSVNT 1328

Query: 502  TLEIEFDVAESVIPSSGT-FHVKLPKKHNVELGITISSP--SSRKPGDPLVISDIKKGSV 558
            + ++ F    S  P  G  F V+L K  N  LGI+++    +S + G   V + I +G+ 
Sbjct: 1329 SNKMNFKTFSSSPPKPGDIFEVELAKNDN-SLGISVTGGVNTSVRHGGIYVKAVIPQGA- 1386

Query: 559  AHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDE------------ 606
            A   G +  GD++LA++ + L+  + + AV+ L+    +V L + K +            
Sbjct: 1387 AESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTP 1446

Query: 607  -----DNSDEQESSGAIIYTVELKRY----------------GGPLGITISGTEEPFDPI 645
                 D + + +    +  T ++K Y                   LG + S  +      
Sbjct: 1447 QCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQ 1506

Query: 646  IISSLTK------GGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKI 699
            I +S+ +      G  A  +G I +GD IL +N +SLKG    E I  L+     V L +
Sbjct: 1507 INASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLL 1566

Query: 700  KKQTDAQSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDMYPSTVPSVDSAVDSWDG 759
             +                                  PG L ++  + +  + S       
Sbjct: 1567 CR--------------------------------PPPGVLPEIDTALLTPLQSPAQVLPN 1594

Query: 760  SAIDTSYGTQGTSFQASGYNFNTYDWRSPKQRGSLSPVTKPRSQTYPDVGLSYEDWDRST 819
            S+ D+S        Q++  + N    +S KQ  S S     R  +Y D   S ED D  T
Sbjct: 1595 SSKDSS--QPSCVEQSTSSDENEMSDKSKKQCKSPS-----RRDSYSDSSGSGED-DLVT 1646

Query: 820  ASGFAGAADSAETEQEENFWSQALEDLETCGQSGILRELEEKADRRVSLRNMTLL-ATIM 878
            A   A  ++S         WS AL    +   S      E    +  ++  M      I 
Sbjct: 1647 AP--ANISNST--------WSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIP 1696

Query: 879  SGSTMSLNHEAPTPRSQLGRQASFQERSSSRPHYSQTTRSNTLPSDVGRKSVTLRKMKQE 938
            +      ++ +P P      Q S+Q +S S    S         S+  R+      +K +
Sbjct: 1697 NKPEFEDSNPSPLPPDMAPGQ-SYQPQSESASSSSMDKYHIHHISEPTRQE-NWTPLKND 1754

Query: 939  IKEIMSPTPVELHKVTLYKDSDMEDFGFSVADGLLEKGVYVKNIRPAGPGDLGGLKPYDR 998
            ++  +    +E+  +     S+    GF+V  G    G YV ++        G LKP DR
Sbjct: 1755 LENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDR 1814

Query: 999  LLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISR 1032
            L++VN     +      V L+  +   + LVI R
Sbjct: 1815 LIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR 1848



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 70/272 (25%), Positives = 107/272 (39%), Gaps = 66/272 (24%)

Query: 19   DESPYTKSASQTKPPDGALAVRRQSIPEEFK---------GSTVVELMKKEGTTLGLTVS 69
            DE+ Y+ S     P   + +    S    FK         G      + K   +LG++V+
Sbjct: 1305 DEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVT 1364

Query: 70   GGIDKDGKPRVSNLRQGGI---------AARSD-QLDVGDYIKAVNGINLAKFRHDEIIS 119
            GG++       +++R GGI         AA SD ++  GD + AVNG++L    H + + 
Sbjct: 1365 GGVN-------TSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVE 1417

Query: 120  LLKNVGERVVLEVEYELPPVSV------------------QGSSVIFRTV---------- 151
             L+N G+ V L +E    P S                   QG   + +T           
Sbjct: 1418 TLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTE 1477

Query: 152  ----EVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVR-----PGGPADREGTIKPGDR 202
                EV L K  +  GF     + +D      +  + VR     PG PA   G I  GD 
Sbjct: 1478 ENTFEVKLFKNSSGLGFSF---SREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDV 1534

Query: 203  LLSVDGIRLLGTTHAEAMSILKQCGQEAALLI 234
            +L V+G  L G +  E +S L+    E  LL+
Sbjct: 1535 ILKVNGASLKGLSQQEVISALRGTAPEVFLLL 1566



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 94/426 (22%), Positives = 159/426 (37%), Gaps = 82/426 (19%)

Query: 645  IIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTD 704
            I ISS+  GG A+  G +  GDR++++NS SL+G     AI +LQ A E VTL I     
Sbjct: 1102 IFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVI----- 1156

Query: 705  AQSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDMYPSTVPSVDSAVDSWDGSAIDT 764
            +Q      K P              S+P     ++ +    +    DSA+D    S+   
Sbjct: 1157 SQPKEKISKVP--------------STPVHLTNEMKNYMKKSSYMQDSAID----SSSKD 1198

Query: 765  SYGTQGTSFQASGYNFNTYDWRSPKQRGSLSPVTKPRSQTYPDVGLSYEDWDRSTASGFA 824
             + ++GT    S    N++      + GSLS           D         +S  +GF 
Sbjct: 1199 HHWSRGTLRHISE---NSFGPSGGLREGSLSS---------QDSRTESASLSQSQVNGFF 1246

Query: 825  GAADSAETEQEENFWSQALEDLETCGQSGILRELEEKADRRVSLRNMTLLATIMSGSTMS 884
             +    +T QE    S +           ++ +  EK                    T +
Sbjct: 1247 ASHLGDQTWQESQHGSPS---------PSVISKATEK-------------------ETFT 1278

Query: 885  LNHEAPTPRSQLGRQASFQERSSS---RPHYSQTTRSNTLPSDVGRKSVTLRKMKQEIKE 941
             ++++ T +  +     + +R  S      YS +    T   +      T  KM  +   
Sbjct: 1279 DSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFS 1338

Query: 942  IMSPTPVELHKVTLYKDSDMEDFGFSVADG----LLEKGVYVKNIRPAGPGDLGG-LKPY 996
               P P ++ +V L K+ +    G SV  G    +   G+YVK + P G  +  G +   
Sbjct: 1339 SSPPKPGDIFEVELAKNDN--SLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKG 1396

Query: 997  DRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISRN---------PLASQKSIDQQSLP 1047
            DR+L VN V          V  +  +G  + L++ +          P+  Q ++  Q+  
Sbjct: 1397 DRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQ 1456

Query: 1048 GDWSEQ 1053
            G   E+
Sbjct: 1457 GQGPEK 1462



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 52/194 (26%), Positives = 87/194 (44%), Gaps = 9/194 (4%)

Query: 190  PADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASG 249
            PA  +G +KPGDRL+ V+   +   TH +A+++L+   +   L+I     V++       
Sbjct: 1802 PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIG---RVLELPRIPML 1858

Query: 250  P-LLVEVAKTPG-ASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGT 307
            P LL ++  T     LG +L        QV+ I  I   S+A   G L + D I  ++G 
Sbjct: 1859 PHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGV 1918

Query: 308  SMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHAALVSSSFSPTSMSAYSLSS 367
            S +  TL E  + L  +   +   +L   +  L +      + VS+  S     +YS+ S
Sbjct: 1919 STQGMTLEEVNRALDMSLPSL---VLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGS 1975

Query: 368  LNMGTL-PRSLYST 380
             +   L P   +ST
Sbjct: 1976 CSQPALTPNDSFST 1989



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 103/518 (19%), Positives = 188/518 (36%), Gaps = 64/518 (12%)

Query: 548  LVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDED 607
            + IS +  G  A   G L+ GD+L++++++ L+  S   A++ILQ   + V L I + ++
Sbjct: 1102 IFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKE 1161

Query: 608  NSDEQESSGAIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDR 667
               +  S+  +  T E+K Y                   I S +K     R    HI + 
Sbjct: 1162 KISKVPST-PVHLTNEMKNY--------MKKSSYMQDSAIDSSSKDHHWSRGTLRHISEN 1212

Query: 668  ILAINS-------SSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQSASSPKKFPISSHL 720
                +        SS   +  S ++   Q+ G   +    +        SP    IS   
Sbjct: 1213 SFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKAT 1272

Query: 721  SDLGDVEEDSSPAQKPGKLSDMYPSTVPSVDSAVDSWDGSAIDTSYGTQGTSFQASGYNF 780
                  + + S  +KPG +SD+                     T Y  +G S        
Sbjct: 1273 EKETFTDSNQSKTKKPG-ISDV---------------------TDYSDRGDSDMDEATYS 1310

Query: 781  NTYDWRSPKQRGSLSPVT------KPRSQTYPDVGLSYE----DWDRSTASGFAGAADSA 830
            ++ D ++PKQ  S S  T      K  S + P  G  +E      D S      G  +++
Sbjct: 1311 SSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTS 1370

Query: 831  ETEQEENFWSQALEDLETCGQSGILRELEEKADRRVSLRNMTLLATIMSGSTMSLNHEAP 890
               +    + +A+         G +     K DR +++  ++L       +  +L +   
Sbjct: 1371 V--RHGGIYVKAVIPQGAAESDGRIH----KGDRVLAVNGVSLEGATHKQAVETLRNTGQ 1424

Query: 891  TPRSQLGRQASFQERSSSRPHYSQTTRSNTLPSDVGRKSVTLRKMKQEIKEIMSPTPVEL 950
                 L +  S     +S+ H   T +      +   +     K   ++K+    T    
Sbjct: 1425 VVHLLLEKGQS----PTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENT 1480

Query: 951  HKVTLYKDSDMEDFGFSVADGLLEKG-----VYVKNIRPAGP-GDLGGLKPYDRLLQVNH 1004
             +V L+K+S    F FS  D L+ +      V VK + P  P  + G +   D +L+VN 
Sbjct: 1481 FEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNG 1540

Query: 1005 VRTRDFDCCLVVPLIAESGNKLDLVISRNPLASQKSID 1042
               +      V+  +  +  ++ L++ R P      ID
Sbjct: 1541 ASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEID 1578



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 31/96 (32%), Positives = 48/96 (50%), Gaps = 6/96 (6%)

Query: 942  IMSPTPVELHKVTLYKDSDMEDFGFSVADG----LLEKGVYVKNIRPAGPGDLGG-LKPY 996
            I+S    E+  V L KD+     GF +  G     L+ G+++ ++ P GP DL G LKP 
Sbjct: 1064 IVSSPEREITLVNLKKDAKY-GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPG 1122

Query: 997  DRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISR 1032
            DRL+ VN V          + ++  +   + LVIS+
Sbjct: 1123 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQ 1158



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 51/220 (23%), Positives = 93/220 (42%), Gaps = 11/220 (5%)

Query: 522  VKLPKKHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDN 581
            + L K     LG T++  + R       + D+ +   A   G L+ GD+L+ +++  + N
Sbjct: 1770 ITLIKSEKGSLGFTVTKGNQRIG---CYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTN 1825

Query: 582  CSMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEP 641
             +  DAV +L+     V+L I +  +          ++  + L      LG ++ G  + 
Sbjct: 1826 MTHTDAVNLLRAASKTVRLVIGRVLE-LPRIPMLPHLLPDITLTCNKEELGFSLCGGHDS 1884

Query: 642  -FDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIK 700
             +  + IS +    +A   G + + D I  +N  S +G  L E    L M+  ++ LK  
Sbjct: 1885 LYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKAT 1944

Query: 701  KQTDAQSASSPKKFPISSHLSDLGD----VEEDSSPAQKP 736
            +  D     S K+  +S+  S  G+    V   S PA  P
Sbjct: 1945 R-NDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTP 1983



 Score = 38.1 bits (87), Expect = 0.045
 Identities = 31/115 (26%), Positives = 54/115 (46%), Gaps = 5/115 (4%)

Query: 52   TVVELMKKEGTTLGLTVSGGIDKDGKPR----VSNLRQGGIAARSDQLDVGDYIKAVNGI 107
            T+V L K     LG  + GG +K G+      +S++  GG A     L  GD + +VN +
Sbjct: 1073 TLVNLKKDAKYGLGFQIIGG-EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSV 1131

Query: 108  NLAKFRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKEGNTF 162
            +L    H   I +L+N  E V L +      +S   S+ +  T E+  + + +++
Sbjct: 1132 SLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSY 1186



 Score = 35.4 bits (80), Expect = 0.29
 Identities = 33/98 (33%), Positives = 45/98 (45%), Gaps = 5/98 (5%)

Query: 451  ISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVA 510
            IS I   S A   G LQ+ D +  +NG+ T+  T EE ++ L D S+ S V      D+ 
Sbjct: 1891 ISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRAL-DMSLPSLVLKATRNDL- 1948

Query: 511  ESVIPSSGTFHVKLPK--KHNVELGITISSPSSRKPGD 546
              V+PSS    V  PK  K N    +   S  +  P D
Sbjct: 1949 -PVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPND 1985


>gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]
          Length = 728

 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 91/345 (26%), Positives = 143/345 (41%), Gaps = 52/345 (15%)

Query: 426 DPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTF 485
           DP     I+L G    +ET     +I +I  D    R G L  GD ++ +NG+   +   
Sbjct: 281 DPSESLSIRLVGG---SETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPH 337

Query: 486 EEASQLLRDSSITSKVTL--EIEF------DVAESVIPSSGTFHVKLPKKHNVE-LGITI 536
             A +LLR       +T+  E +F         ++  P   +FHV L K    E LGI +
Sbjct: 338 NYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKL 397

Query: 537 SSPSSRKPGDP-LVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCE 595
                RK  +P + I ++  G VA+R G LE  D++LAI+   L   S E A  ++Q  E
Sbjct: 398 ----VRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASE 453

Query: 596 DLVKLKIRKD--------------EDNSDEQESSGAIIYTVE---------------LKR 626
             V L + +                 N       G    T +                K 
Sbjct: 454 RRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKD 513

Query: 627 YGGPLGITISG--TEEPFD-PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSE 683
            G  LG+T++G  +   +D PI + S+  GG+  R G I  GD +L ++   L     SE
Sbjct: 514 PGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSE 573

Query: 684 AIHLLQMAGETVTLK---IKKQTDAQSASSPKKFPISSHLSDLGD 725
           A+ LL+    ++ LK   +K+    +  SSP     + +++   D
Sbjct: 574 AVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSD 618



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 60/215 (27%), Positives = 96/215 (44%), Gaps = 34/215 (15%)

Query: 53  VVELMKKEGTTLGLTVSGGIDK---DGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINL 109
           VV + K  G +LG+TV+GG      D    V ++  GG+ +R  ++  GD +  V+G+ L
Sbjct: 507 VVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVEL 566

Query: 110 AKFRHDEIISLLKNVGERVVLEV----EYE-----------------LPPVSVQGSSV-- 146
            +    E ++LLK     +VL+     EYE                  PP     S V  
Sbjct: 567 TEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMW 626

Query: 147 ------IFRTVEVTLHKE-GNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKP 199
                 ++   ++ L +    + GF I GG +++ N ++P  I  +  G PA  +G I+ 
Sbjct: 627 LELPRCLYNCKDIVLRRNTAGSLGFCIVGG-YEEYNGNKPFFIKSIVEGTPAYNDGRIRC 685

Query: 200 GDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLI 234
           GD LL+V+G    G  HA    +LK+      L I
Sbjct: 686 GDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 720



 Score = 67.4 bits (163), Expect = 7e-11
 Identities = 75/304 (24%), Positives = 122/304 (40%), Gaps = 64/304 (21%)

Query: 460 AERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSS-----ITSKVTLEIEFDVAE--- 511
           A R G L+  DRV+AING      + E A+ L++ S      + S+   +   D+ +   
Sbjct: 417 AYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAG 476

Query: 512 -----SVIPSSG-------------TFH---VKLPKKHNVELGITISSPSSRKPGD-PLV 549
                S  P  G             T H   V + K     LG+T++  +S +  D P+ 
Sbjct: 477 WNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIY 536

Query: 550 ISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNS 609
           +  ++ G V  R G ++ GD LL +D + L   S  +AV +L++    + LK  + ++  
Sbjct: 537 VISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYE 596

Query: 610 DEQESSGAI------------------IYTVELKRY-------------GGPLGITISGT 638
            +++ S                     +  +EL R               G LG  I G 
Sbjct: 597 PQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGG 656

Query: 639 EEPFD---PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETV 695
            E ++   P  I S+ +G  A   G I  GD +LA+N  S  G   +    LL+     +
Sbjct: 657 YEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRI 716

Query: 696 TLKI 699
           TL I
Sbjct: 717 TLTI 720



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 94/462 (20%), Positives = 176/462 (38%), Gaps = 80/462 (17%)

Query: 80  VSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEYELPPV 139
           + ++ + G+ AR  +L  GD I  VNG++++   H+  + LL+   + + L V  E    
Sbjct: 303 IQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFR 362

Query: 140 SVQGSSV--IFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRP-VVITCVRPGGPADREGT 196
           S         +R  + + H   N      + G    R    P V I  V  GG A R G 
Sbjct: 363 SRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQ 422

Query: 197 IKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMD-----------SVA 245
           ++  DR+L+++G  L   +   A  +++   +   L++   V               + +
Sbjct: 423 LEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGS 482

Query: 246 TASGP------------------LLVEVAKTPGASLGVALTTSMCCNKQ--VIVIDKIKS 285
            + GP                   +V + K PG SLG+ +       +    I +  ++ 
Sbjct: 483 WSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEP 542

Query: 286 ASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEIL--PHHQTRLALK 343
             +  R G +  GD +L++DG  +   + +EA   L  T+  + L+ L    ++ +    
Sbjct: 543 GGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCS 602

Query: 344 GPDHAALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLA 403
            P   A + S+ +    S +S S +    LPR LY+                        
Sbjct: 603 SP---AALDSNHNMAPPSDWSPSWVMWLELPRCLYNCK---------------------- 637

Query: 404 SSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERC 463
                           ++VL  +     G  + G  +     + P  I  I   +PA   
Sbjct: 638 ----------------DIVLRRNTAGSLGFCIVGG-YEEYNGNKPFFIKSIVEGTPAYND 680

Query: 464 GVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEI 505
           G ++ GD ++A+NG  T        ++LL++  +  ++TL I
Sbjct: 681 GRIRCGDILLAVNGRSTSGMIHACLARLLKE--LKGRITLTI 720



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 90/464 (19%), Positives = 166/464 (35%), Gaps = 85/464 (18%)

Query: 180 VVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLI----- 234
           ++I  +   G   R+G + PGD +L V+G+ +    H  A+ +L+Q  Q   L +     
Sbjct: 301 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQK 360

Query: 235 ---EYDVSVMDSVATASGPLLVEVAK-TPGASLGVALTTSMCCNKQVIVIDKIKSASIAD 290
                +    D+         V + K +P   LG+ L   +  ++  + I  +    +A 
Sbjct: 361 FRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKV--DEPGVFIFNVLDGGVAY 418

Query: 291 RCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHAAL 350
           R G L   D +L+I+G  + Y +   A   +  +  +V L +      ++  + PD    
Sbjct: 419 RHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVV----SRQVRQRSPD---- 470

Query: 351 VSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLA 410
           +       S  ++S         P+ L+ T                              
Sbjct: 471 IFQEAGWNSNGSWSPGPGERSNTPKPLHPT------------------------------ 500

Query: 411 GQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGD 470
              +      V +  DP    G+ + G     E    P  +  +E      R G ++ GD
Sbjct: 501 ---ITCHEKVVNIQKDPGESLGMTVAGGASHRE-WDLPIYVISVEPGGVISRDGRIKTGD 556

Query: 471 RVMAINGIP-TEDSTFEEASQLLRDSSITSKVTLEIE-------------FDVAESVIPS 516
            ++ ++G+  TE S  E  + L R SS      LE++              D   ++ P 
Sbjct: 557 ILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPP 616

Query: 517 SG-----TFHVKLPK----------KHNV--ELGITISSPSSRKPGD-PLVISDIKKGSV 558
           S         ++LP+          + N    LG  I        G+ P  I  I +G+ 
Sbjct: 617 SDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTP 676

Query: 559 AHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKI 602
           A+  G +  GD LLA++             ++L++ +  + L I
Sbjct: 677 AYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 720


>gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens]
          Length = 632

 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 91/345 (26%), Positives = 143/345 (41%), Gaps = 52/345 (15%)

Query: 426 DPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTF 485
           DP     I+L G    +ET     +I +I  D    R G L  GD ++ +NG+   +   
Sbjct: 185 DPSESLSIRLVGG---SETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPH 241

Query: 486 EEASQLLRDSSITSKVTL--EIEF------DVAESVIPSSGTFHVKLPKKHNVE-LGITI 536
             A +LLR       +T+  E +F         ++  P   +FHV L K    E LGI +
Sbjct: 242 NYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKL 301

Query: 537 SSPSSRKPGDP-LVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCE 595
                RK  +P + I ++  G VA+R G LE  D++LAI+   L   S E A  ++Q  E
Sbjct: 302 ----VRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASE 357

Query: 596 DLVKLKIRKD--------------EDNSDEQESSGAIIYTVE---------------LKR 626
             V L + +                 N       G    T +                K 
Sbjct: 358 RRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKD 417

Query: 627 YGGPLGITISG--TEEPFD-PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSE 683
            G  LG+T++G  +   +D PI + S+  GG+  R G I  GD +L ++   L     SE
Sbjct: 418 PGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSE 477

Query: 684 AIHLLQMAGETVTLK---IKKQTDAQSASSPKKFPISSHLSDLGD 725
           A+ LL+    ++ LK   +K+    +  SSP     + +++   D
Sbjct: 478 AVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSD 522



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 60/215 (27%), Positives = 96/215 (44%), Gaps = 34/215 (15%)

Query: 53  VVELMKKEGTTLGLTVSGGIDK---DGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINL 109
           VV + K  G +LG+TV+GG      D    V ++  GG+ +R  ++  GD +  V+G+ L
Sbjct: 411 VVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVEL 470

Query: 110 AKFRHDEIISLLKNVGERVVLEV----EYE-----------------LPPVSVQGSSV-- 146
            +    E ++LLK     +VL+     EYE                  PP     S V  
Sbjct: 471 TEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMW 530

Query: 147 ------IFRTVEVTLHKE-GNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKP 199
                 ++   ++ L +    + GF I GG +++ N ++P  I  +  G PA  +G I+ 
Sbjct: 531 LELPRCLYNCKDIVLRRNTAGSLGFCIVGG-YEEYNGNKPFFIKSIVEGTPAYNDGRIRC 589

Query: 200 GDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLI 234
           GD LL+V+G    G  HA    +LK+      L I
Sbjct: 590 GDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 624



 Score = 67.4 bits (163), Expect = 7e-11
 Identities = 75/304 (24%), Positives = 122/304 (40%), Gaps = 64/304 (21%)

Query: 460 AERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSS-----ITSKVTLEIEFDVAE--- 511
           A R G L+  DRV+AING      + E A+ L++ S      + S+   +   D+ +   
Sbjct: 321 AYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAG 380

Query: 512 -----SVIPSSG-------------TFH---VKLPKKHNVELGITISSPSSRKPGD-PLV 549
                S  P  G             T H   V + K     LG+T++  +S +  D P+ 
Sbjct: 381 WNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIY 440

Query: 550 ISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNS 609
           +  ++ G V  R G ++ GD LL +D + L   S  +AV +L++    + LK  + ++  
Sbjct: 441 VISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYE 500

Query: 610 DEQESSGAI------------------IYTVELKRY-------------GGPLGITISGT 638
            +++ S                     +  +EL R               G LG  I G 
Sbjct: 501 PQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGG 560

Query: 639 EEPFD---PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETV 695
            E ++   P  I S+ +G  A   G I  GD +LA+N  S  G   +    LL+     +
Sbjct: 561 YEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRI 620

Query: 696 TLKI 699
           TL I
Sbjct: 621 TLTI 624



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 94/462 (20%), Positives = 176/462 (38%), Gaps = 80/462 (17%)

Query: 80  VSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEYELPPV 139
           + ++ + G+ AR  +L  GD I  VNG++++   H+  + LL+   + + L V  E    
Sbjct: 207 IQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFR 266

Query: 140 SVQGSSV--IFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRP-VVITCVRPGGPADREGT 196
           S         +R  + + H   N      + G    R    P V I  V  GG A R G 
Sbjct: 267 SRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQ 326

Query: 197 IKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMD-----------SVA 245
           ++  DR+L+++G  L   +   A  +++   +   L++   V               + +
Sbjct: 327 LEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGS 386

Query: 246 TASGP------------------LLVEVAKTPGASLGVALTTSMCCNKQ--VIVIDKIKS 285
            + GP                   +V + K PG SLG+ +       +    I +  ++ 
Sbjct: 387 WSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEP 446

Query: 286 ASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEIL--PHHQTRLALK 343
             +  R G +  GD +L++DG  +   + +EA   L  T+  + L+ L    ++ +    
Sbjct: 447 GGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCS 506

Query: 344 GPDHAALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLA 403
            P   A + S+ +    S +S S +    LPR LY+                        
Sbjct: 507 SP---AALDSNHNMAPPSDWSPSWVMWLELPRCLYNCK---------------------- 541

Query: 404 SSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERC 463
                           ++VL  +     G  + G  +     + P  I  I   +PA   
Sbjct: 542 ----------------DIVLRRNTAGSLGFCIVGG-YEEYNGNKPFFIKSIVEGTPAYND 584

Query: 464 GVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEI 505
           G ++ GD ++A+NG  T        ++LL++  +  ++TL I
Sbjct: 585 GRIRCGDILLAVNGRSTSGMIHACLARLLKE--LKGRITLTI 624



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 90/464 (19%), Positives = 166/464 (35%), Gaps = 85/464 (18%)

Query: 180 VVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLI----- 234
           ++I  +   G   R+G + PGD +L V+G+ +    H  A+ +L+Q  Q   L +     
Sbjct: 205 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQK 264

Query: 235 ---EYDVSVMDSVATASGPLLVEVAK-TPGASLGVALTTSMCCNKQVIVIDKIKSASIAD 290
                +    D+         V + K +P   LG+ L   +  ++  + I  +    +A 
Sbjct: 265 FRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKV--DEPGVFIFNVLDGGVAY 322

Query: 291 RCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHAAL 350
           R G L   D +L+I+G  + Y +   A   +  +  +V L +      ++  + PD    
Sbjct: 323 RHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVV----SRQVRQRSPD---- 374

Query: 351 VSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLA 410
           +       S  ++S         P+ L+ T                              
Sbjct: 375 IFQEAGWNSNGSWSPGPGERSNTPKPLHPT------------------------------ 404

Query: 411 GQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGD 470
              +      V +  DP    G+ + G     E    P  +  +E      R G ++ GD
Sbjct: 405 ---ITCHEKVVNIQKDPGESLGMTVAGGASHRE-WDLPIYVISVEPGGVISRDGRIKTGD 460

Query: 471 RVMAINGIP-TEDSTFEEASQLLRDSSITSKVTLEIE-------------FDVAESVIPS 516
            ++ ++G+  TE S  E  + L R SS      LE++              D   ++ P 
Sbjct: 461 ILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPP 520

Query: 517 SG-----TFHVKLPK----------KHNV--ELGITISSPSSRKPGD-PLVISDIKKGSV 558
           S         ++LP+          + N    LG  I        G+ P  I  I +G+ 
Sbjct: 521 SDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTP 580

Query: 559 AHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKI 602
           A+  G +  GD LLA++             ++L++ +  + L I
Sbjct: 581 AYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 624


>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
            sapiens]
          Length = 1287

 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 68/230 (29%), Positives = 93/230 (40%), Gaps = 45/230 (19%)

Query: 138  PVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRP---VVITCVRPGGPADRE 194
            P  +    + F    V L KE  T GF + GG     N S P   + +  + PGGPA +E
Sbjct: 918  PPEISAGEIYF----VELVKEDGTLGFSVTGGI----NTSVPYGGIYVKSIVPGGPAAKE 969

Query: 195  GTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDV--------SVMDS--- 243
            G I  GDRLL VDG+ L G TH +A+  L   GQ A L++E  V        S  DS   
Sbjct: 970  GQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGD 1029

Query: 244  ------------------VATASGPLLVEVAKTPGASLG---VALTTSMCCN--KQVIVI 280
                              V+   GP      K     LG   V +    C +    ++ I
Sbjct: 1030 ERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRI 1089

Query: 281  DKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKL 330
             ++     A+  GA+  GD IL+++G S E     E    L     +V L
Sbjct: 1090 KRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTL 1139



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 72/299 (24%), Positives = 125/299 (41%), Gaps = 31/299 (10%)

Query: 417  ETTEVVLTADPVTGFGIQLQGSVFATETLSSPPL-ISYIEADSPAERCGVLQIGDRVMAI 475
            E   V L  DP  GFG  +    ++ +  + P + IS I    PAE+   ++ G +++A+
Sbjct: 750  EIVRVTLKRDPHRGFGFVINEGEYSGQ--ADPGIFISSIIPGGPAEKAKTIKPGGQILAL 807

Query: 476  NGIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGIT 535
            N I  E  TF  A +++++S         IE  +++S     G       ++ N      
Sbjct: 808  NHISLEGFTFNMAVRMIQNSPDN------IELIISQS----KGVGGNNPDEEKNSTANSG 857

Query: 536  ISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCE 595
            +SS          ++S   +GS+   T   +   +        LD   ++  V  L+   
Sbjct: 858  VSSTD--------ILSFGYQGSLLSHTQDQDRNTE-------ELDMAGVQSLVPRLRHQL 902

Query: 596  DLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISG---TEEPFDPIIISSLTK 652
              + LK           E S   IY VEL +  G LG +++G   T  P+  I + S+  
Sbjct: 903  SFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVP 962

Query: 653  GGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQSASSP 711
            GG A + G I  GDR+L ++   L G    +A+  L   G+   L ++++    +   P
Sbjct: 963  GGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCP 1021



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 71/237 (29%), Positives = 101/237 (42%), Gaps = 35/237 (14%)

Query: 32   PPDGALAVRRQSIPEEFKGSTV-VELMKKEGTTLGLTVSGGIDKD---GKPRVSNLRQGG 87
            P  GA +    S PE   G    VEL+K++GT LG +V+GGI+     G   V ++  GG
Sbjct: 906  PLKGAGSSCPPSPPEISAGEIYFVELVKEDGT-LGFSVTGGINTSVPYGGIYVKSIVPGG 964

Query: 88   IAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEYELPPVSVQ----- 142
             AA+  Q+  GD +  V+G+ L    H + +  L   G+   L +E  +P  + Q     
Sbjct: 965  PAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSAN 1024

Query: 143  -------------------GSSVIFRT----VEVTLHKEGN--TFGFVIRGGAHDDRNKS 177
                                SS +  T     EV L K  N   F FV          KS
Sbjct: 1025 DSMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKS 1084

Query: 178  RPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLI 234
              V I  + PG PA+  G I  GD +L+V+G    G    E + +L+   QE  LL+
Sbjct: 1085 DLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLL 1141



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 82/362 (22%), Positives = 139/362 (38%), Gaps = 57/362 (15%)

Query: 516  SSGTFHVKLPKKHNVELGITISSP-SSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAI 574
            S+G  +     K +  LG +++   ++  P   + +  I  G  A + G +  GD+LL +
Sbjct: 922  SAGEIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQV 981

Query: 575  DNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNSDEQ----------ESSGAIIYT--- 621
            D + L   + + AVQ L     + +L + +    S +Q          E +   + T   
Sbjct: 982  DGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALP 1041

Query: 622  ----------------VELKRYGGPLGITISGTEEPF------DPIIISSLTKGGLAERT 659
                            V+LK+    LG +    E+        D + I  L  G  AE  
Sbjct: 1042 GRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEEN 1101

Query: 660  GAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQSASSPKKFPISSH 719
            GAI  GD ILA+N  S +G    E +HLL+ A + VTL + +             P    
Sbjct: 1102 GAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCR-------------PPPGA 1148

Query: 720  LSDL-GDVEEDSSPAQKPGKLSDMYPSTVPSVDSAVDSWDGSAIDTSYGTQGTSFQASGY 778
            L +L  + +     A K    +    S    +    DSW  SA   +    G   ++S  
Sbjct: 1149 LPELEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQK 1208

Query: 779  NFNTYDWRSPKQRGSLSPVTKPRSQTYPDVGLSYEDWDRSTASGFAGAADSAETEQEENF 838
                  W   ++R   S +T    +++P +   +++ D ST       A S E +  +N 
Sbjct: 1209 AIREAQWGQNRERPWASSLTH-SPESHPHLCKLHQERDEST------LATSLEKDVRQNC 1261

Query: 839  WS 840
            +S
Sbjct: 1262 YS 1263



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 30/91 (32%), Positives = 50/91 (54%), Gaps = 2/91 (2%)

Query: 151 VEVTLHKEGNT-FGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGI 209
           V VTL ++ +  FGFVI  G +  +     + I+ + PGGPA++  TIKPG ++L+++ I
Sbjct: 752 VRVTLKRDPHRGFGFVINEGEYSGQ-ADPGIFISSIIPGGPAEKAKTIKPGGQILALNHI 810

Query: 210 RLLGTTHAEAMSILKQCGQEAALLIEYDVSV 240
            L G T   A+ +++       L+I     V
Sbjct: 811 SLEGFTFNMAVRMIQNSPDNIELIISQSKGV 841



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 27/101 (26%), Positives = 54/101 (53%), Gaps = 6/101 (5%)

Query: 949  ELHKVTLYKDSDMEDFGFSVADG----LLEKGVYVKNIRPAGPGDLGG-LKPYDRLLQVN 1003
            E+ +VTL +D     FGF + +G      + G+++ +I P GP +    +KP  ++L +N
Sbjct: 750  EIVRVTLKRDPH-RGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALN 808

Query: 1004 HVRTRDFDCCLVVPLIAESGNKLDLVISRNPLASQKSIDQQ 1044
            H+    F   + V +I  S + ++L+IS++      + D++
Sbjct: 809  HISLEGFTFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEE 849



 Score = 34.7 bits (78), Expect = 0.50
 Identities = 34/107 (31%), Positives = 47/107 (43%), Gaps = 8/107 (7%)

Query: 949  ELHKVTLYKDSDMEDFGFSVADGLLEK----GVYVKNIRPAGP-GDLGGLKPYDRLLQVN 1003
            E++ V L K+      GFSV  G+       G+YVK+I P GP    G +   DRLLQV+
Sbjct: 925  EIYFVELVKEDGT--LGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVD 982

Query: 1004 HVRTRDFDCCLVVPLIAESGNKLDLVISRN-PLASQKSIDQQSLPGD 1049
             V          V  +   G    LV+ R  P ++Q+        GD
Sbjct: 983  GVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGD 1029



 Score = 34.7 bits (78), Expect = 0.50
 Identities = 16/35 (45%), Positives = 21/35 (60%)

Query: 459  PAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLR 493
            PAE  G +  GD ++A+NG  TE   F+E   LLR
Sbjct: 1097 PAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLR 1131


>gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo
            sapiens]
          Length = 1309

 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 68/230 (29%), Positives = 93/230 (40%), Gaps = 45/230 (19%)

Query: 138  PVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRP---VVITCVRPGGPADRE 194
            P  +    + F    V L KE  T GF + GG     N S P   + +  + PGGPA +E
Sbjct: 940  PPEISAGEIYF----VELVKEDGTLGFSVTGGI----NTSVPYGGIYVKSIVPGGPAAKE 991

Query: 195  GTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDV--------SVMDS--- 243
            G I  GDRLL VDG+ L G TH +A+  L   GQ A L++E  V        S  DS   
Sbjct: 992  GQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGD 1051

Query: 244  ------------------VATASGPLLVEVAKTPGASLG---VALTTSMCCN--KQVIVI 280
                              V+   GP      K     LG   V +    C +    ++ I
Sbjct: 1052 ERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRI 1111

Query: 281  DKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKL 330
             ++     A+  GA+  GD IL+++G S E     E    L     +V L
Sbjct: 1112 KRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTL 1161



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 72/299 (24%), Positives = 125/299 (41%), Gaps = 31/299 (10%)

Query: 417  ETTEVVLTADPVTGFGIQLQGSVFATETLSSPPL-ISYIEADSPAERCGVLQIGDRVMAI 475
            E   V L  DP  GFG  +    ++ +  + P + IS I    PAE+   ++ G +++A+
Sbjct: 772  EIVRVTLKRDPHRGFGFVINEGEYSGQ--ADPGIFISSIIPGGPAEKAKTIKPGGQILAL 829

Query: 476  NGIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGIT 535
            N I  E  TF  A +++++S         IE  +++S     G       ++ N      
Sbjct: 830  NHISLEGFTFNMAVRMIQNSPDN------IELIISQS----KGVGGNNPDEEKNSTANSG 879

Query: 536  ISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCE 595
            +SS          ++S   +GS+   T   +   +        LD   ++  V  L+   
Sbjct: 880  VSSTD--------ILSFGYQGSLLSHTQDQDRNTE-------ELDMAGVQSLVPRLRHQL 924

Query: 596  DLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISG---TEEPFDPIIISSLTK 652
              + LK           E S   IY VEL +  G LG +++G   T  P+  I + S+  
Sbjct: 925  SFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVP 984

Query: 653  GGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQSASSP 711
            GG A + G I  GDR+L ++   L G    +A+  L   G+   L ++++    +   P
Sbjct: 985  GGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCP 1043



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 71/237 (29%), Positives = 101/237 (42%), Gaps = 35/237 (14%)

Query: 32   PPDGALAVRRQSIPEEFKGSTV-VELMKKEGTTLGLTVSGGIDKD---GKPRVSNLRQGG 87
            P  GA +    S PE   G    VEL+K++GT LG +V+GGI+     G   V ++  GG
Sbjct: 928  PLKGAGSSCPPSPPEISAGEIYFVELVKEDGT-LGFSVTGGINTSVPYGGIYVKSIVPGG 986

Query: 88   IAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEYELPPVSVQ----- 142
             AA+  Q+  GD +  V+G+ L    H + +  L   G+   L +E  +P  + Q     
Sbjct: 987  PAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSAN 1046

Query: 143  -------------------GSSVIFRT----VEVTLHKEGN--TFGFVIRGGAHDDRNKS 177
                                SS +  T     EV L K  N   F FV          KS
Sbjct: 1047 DSMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKS 1106

Query: 178  RPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLI 234
              V I  + PG PA+  G I  GD +L+V+G    G    E + +L+   QE  LL+
Sbjct: 1107 DLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLL 1163



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 82/362 (22%), Positives = 139/362 (38%), Gaps = 57/362 (15%)

Query: 516  SSGTFHVKLPKKHNVELGITISSP-SSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAI 574
            S+G  +     K +  LG +++   ++  P   + +  I  G  A + G +  GD+LL +
Sbjct: 944  SAGEIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQV 1003

Query: 575  DNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNSDEQ----------ESSGAIIYT--- 621
            D + L   + + AVQ L     + +L + +    S +Q          E +   + T   
Sbjct: 1004 DGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALP 1063

Query: 622  ----------------VELKRYGGPLGITISGTEEPF------DPIIISSLTKGGLAERT 659
                            V+LK+    LG +    E+        D + I  L  G  AE  
Sbjct: 1064 GRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEEN 1123

Query: 660  GAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQSASSPKKFPISSH 719
            GAI  GD ILA+N  S +G    E +HLL+ A + VTL + +             P    
Sbjct: 1124 GAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCR-------------PPPGA 1170

Query: 720  LSDL-GDVEEDSSPAQKPGKLSDMYPSTVPSVDSAVDSWDGSAIDTSYGTQGTSFQASGY 778
            L +L  + +     A K    +    S    +    DSW  SA   +    G   ++S  
Sbjct: 1171 LPELEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQK 1230

Query: 779  NFNTYDWRSPKQRGSLSPVTKPRSQTYPDVGLSYEDWDRSTASGFAGAADSAETEQEENF 838
                  W   ++R   S +T    +++P +   +++ D ST       A S E +  +N 
Sbjct: 1231 AIREAQWGQNRERPWASSLTH-SPESHPHLCKLHQERDEST------LATSLEKDVRQNC 1283

Query: 839  WS 840
            +S
Sbjct: 1284 YS 1285



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 30/91 (32%), Positives = 50/91 (54%), Gaps = 2/91 (2%)

Query: 151 VEVTLHKEGNT-FGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGI 209
           V VTL ++ +  FGFVI  G +  +     + I+ + PGGPA++  TIKPG ++L+++ I
Sbjct: 774 VRVTLKRDPHRGFGFVINEGEYSGQ-ADPGIFISSIIPGGPAEKAKTIKPGGQILALNHI 832

Query: 210 RLLGTTHAEAMSILKQCGQEAALLIEYDVSV 240
            L G T   A+ +++       L+I     V
Sbjct: 833 SLEGFTFNMAVRMIQNSPDNIELIISQSKGV 863



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 27/101 (26%), Positives = 54/101 (53%), Gaps = 6/101 (5%)

Query: 949  ELHKVTLYKDSDMEDFGFSVADG----LLEKGVYVKNIRPAGPGDLGG-LKPYDRLLQVN 1003
            E+ +VTL +D     FGF + +G      + G+++ +I P GP +    +KP  ++L +N
Sbjct: 772  EIVRVTLKRDPH-RGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALN 830

Query: 1004 HVRTRDFDCCLVVPLIAESGNKLDLVISRNPLASQKSIDQQ 1044
            H+    F   + V +I  S + ++L+IS++      + D++
Sbjct: 831  HISLEGFTFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEE 871



 Score = 34.7 bits (78), Expect = 0.50
 Identities = 34/107 (31%), Positives = 47/107 (43%), Gaps = 8/107 (7%)

Query: 949  ELHKVTLYKDSDMEDFGFSVADGLLEK----GVYVKNIRPAGP-GDLGGLKPYDRLLQVN 1003
            E++ V L K+      GFSV  G+       G+YVK+I P GP    G +   DRLLQV+
Sbjct: 947  EIYFVELVKEDGT--LGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVD 1004

Query: 1004 HVRTRDFDCCLVVPLIAESGNKLDLVISRN-PLASQKSIDQQSLPGD 1049
             V          V  +   G    LV+ R  P ++Q+        GD
Sbjct: 1005 GVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGD 1051



 Score = 34.7 bits (78), Expect = 0.50
 Identities = 16/35 (45%), Positives = 21/35 (60%)

Query: 459  PAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLR 493
            PAE  G +  GD ++A+NG  TE   F+E   LLR
Sbjct: 1119 PAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLR 1153


>gi|155969695 membrane-associated guanylate kinase-related  3 isoform
            2 [Homo sapiens]
          Length = 1125

 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 74/288 (25%), Positives = 119/288 (41%), Gaps = 33/288 (11%)

Query: 417  ETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAIN 476
            E  +VVL      GFG  +  S         P  I  +   SPA+RCG L++GD + A+N
Sbjct: 848  EPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVN 907

Query: 477  GIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVK-LPKKHNVELGIT 535
            G    + + +   QL++D+ +T  +T+  E    E   P SGT   +  P   +  +G  
Sbjct: 908  GQSIVELSHDNIVQLIKDAGVTVTLTVIAE---EEHHGPPSGTNSARQSPALQHRPMG-- 962

Query: 536  ISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCE 595
              S ++  PGD   +    +G +     T                  S  D   + Q   
Sbjct: 963  -QSQANHIPGDRSAL----EGEIGKDVSTSY--------------RHSWSDHKHLAQPDT 1003

Query: 596  DLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTKGGL 655
             ++ +   +   N           Y VEL+R     G ++ G +E    + I  L + G 
Sbjct: 1004 AVISVVGSRHNQNLG--------CYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGP 1055

Query: 656  AERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQT 703
            A + G IH+GD+I+ IN    +G   + AI L+Q  G  V L ++  T
Sbjct: 1056 AIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGT 1103



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 125/598 (20%), Positives = 233/598 (38%), Gaps = 92/598 (15%)

Query: 45  PEEFKGSTVVELMKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAV 104
           P + KG  V   +KK     G T+ GG   D   +V N+ + G AA+  ++  GD I  +
Sbjct: 401 PSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDI 460

Query: 105 NGINLAKFRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKEGNTFGF 164
           NG  +    H +++ +             ++L PV+   +  + R   +    E      
Sbjct: 461 NGNCVLGHTHADVVQM-------------FQLVPVNQYVNLTLCRGYPLPDDSEDPVVDI 507

Query: 165 VIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILK 224
           V      + ++ ++    TC+ P          KPG  +L  +G +   T   + ++   
Sbjct: 508 VAATPVINGQSLTKGE--TCMNP-------QDFKPGAMVLEQNG-KSGHTLTGDGLN--- 554

Query: 225 QCGQEAALLIEYDVSVMDSVATASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIK 284
             G   A   E  VS+  S ++    + + + K P    G A+  S    K  +++D   
Sbjct: 555 --GPSDA--SEQRVSMASSGSSQPELVTIPLIKGP-KGFGFAIADSPTGQKVKMILD--- 606

Query: 285 SASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKG 344
               +  C  L  GD I  I   +++  T  +  + L        + +L      +   G
Sbjct: 607 ----SQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLL------ILRGG 656

Query: 345 PDHAALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLAS 404
           P      +   +    +A SL ++N   +P+ +    P    + R    K   S + L S
Sbjct: 657 PPSPTKTAKMKTDKKENAGSLEAIN-EPIPQPM----PFPPSIIRSGSPKLDPSEVYLKS 711

Query: 405 STVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSP---AE 461
            T+    +  +T+  +V L     +GFG ++ G          P    YI A  P   AE
Sbjct: 712 KTL-YEDKPPNTKDLDVFLRKQE-SGFGFRVLGG-------DGPDQSIYIGAIIPLGAAE 762

Query: 462 RCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEI-----------EFDVA 510
           + G L+  D +M I+GIP +  + ++   L+  ++    V L +           E D +
Sbjct: 763 KDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSS 822

Query: 511 ESVIPSSG------------------TFHVKLPKKHNVELGITISSPSSRKPGD--PLVI 550
           ++ I +                     + V L +K N   G  I +  ++ P    P  I
Sbjct: 823 QAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKI 882

Query: 551 SDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDN 608
             + +GS A R G L++GD + A++   +   S ++ VQ+++     V L +  +E++
Sbjct: 883 GRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEH 940



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 143/661 (21%), Positives = 235/661 (35%), Gaps = 126/661 (19%)

Query: 151 VEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIR 210
           V  +L K    FGF I GG   D      + +  V   GPA ++G I PGD ++ ++G  
Sbjct: 409 VRASLKKSTMGFGFTIIGGDRPDEF----LQVKNVLKDGPAAQDGKIAPGDVIVDINGNC 464

Query: 211 LLGTTHAEAMSI--LKQCGQEAALLIEYDVSVMDSVATASGPLLVEVAKTPGASLGVALT 268
           +LG THA+ + +  L    Q   L +     + D    +  P++  VA TP  + G +LT
Sbjct: 465 VLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDD---SEDPVVDIVAATPVIN-GQSLT 520

Query: 269 T-SMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQ 327
               C N Q    D    A + ++ G      H L+ DG +       +     ++ + Q
Sbjct: 521 KGETCMNPQ----DFKPGAMVLEQNGK---SGHTLTGDGLNGPSDASEQRVSMASSGSSQ 573

Query: 328 VKLEILPHHQTRLALKGPDHAALVSSSFSPTSMSAYSL------SSLNMGTLPRSLYSTS 381
            +L  +P       +KGP       +  SPT      +        L  G + + +Y  +
Sbjct: 574 PELVTIP------LIKGPKGFGFAIAD-SPTGQKVKMILDSQWCQGLQKGDIIKEIYHQN 626

Query: 382 PRGTMMRRRLKKKDFKSSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFA 441
            +                             + H +  E VL   PV G  + L   +  
Sbjct: 627 VQ----------------------------NLTHLQVVE-VLKQFPV-GADVPL---LIL 653

Query: 442 TETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKV 501
                SP   + ++ D   E  G L+  +  +    +P   S     S  L  S +  K 
Sbjct: 654 RGGPPSPTKTAKMKTDK-KENAGSLEAINEPIP-QPMPFPPSIIRSGSPKLDPSEVYLK- 710

Query: 502 TLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITISSPSSRKPGDPLVISDIKKGSVAHR 561
                  + E   P++    V L K+   E G          P   + I  I     A +
Sbjct: 711 ----SKTLYEDKPPNTKDLDVFLRKQ---ESGFGFRVLGGDGPDQSIYIGAIIPLGAAEK 763

Query: 562 TGTLELGDKLLAIDNIRLDNCSMEDAVQILQQC--EDLVKLKIRKD---EDNSDEQESSG 616
            G L   D+L+ ID I +   S +  + ++        V L +R+     +   E +SS 
Sbjct: 764 DGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQ 823

Query: 617 AIIYT----VELKRYGGPLGITISGTEEPFDPII-------------------------- 646
           A I T      L R   P        +EP+D ++                          
Sbjct: 824 AFISTQNGSPRLNRAEVP---ARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPH 880

Query: 647 -ISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTDA 705
            I  + +G  A+R G + +GD I A+N  S+        + L++ AG TVTL +  + + 
Sbjct: 881 KIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEH 940

Query: 706 QSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDMYPSTVPSVDSAVDSWDGSAIDTS 765
               S             G      SPA +   +     + +P   SA++   G  + TS
Sbjct: 941 HGPPS-------------GTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTS 987

Query: 766 Y 766
           Y
Sbjct: 988 Y 988



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 67/292 (22%), Positives = 111/292 (38%), Gaps = 53/292 (18%)

Query: 54   VELMKKEGTTLGLTVSGGIDKDGKP-------RVSNLRQGGIAARSDQLDVGDYIKAVNG 106
            V L +KE    G  +   +    KP       ++  + +G  A R  +L VGD+I AVNG
Sbjct: 852  VVLQRKENEGFGFVI---LTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNG 908

Query: 107  INLAKFRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKEGNTFGFVI 166
             ++ +  HD I+ L+K+ G  V L V                   E   H          
Sbjct: 909  QSIVELSHDNIVQLIKDAGVTVTLTV-----------------IAEEEHH---------- 941

Query: 167  RGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQC 226
              G     N +R       RP G +  +    PGDR        L G    +  +  +  
Sbjct: 942  --GPPSGTNSARQSPALQHRPMGQS--QANHIPGDR------SALEGEIGKDVSTSYRHS 991

Query: 227  GQEAALLIEYDVSVMDSVATASGPLL----VEVAKTPGASLGVALTTSMCCNKQVIVIDK 282
              +   L + D +V+  V +     L    VE+ + P    G +L      N  + ++ +
Sbjct: 992  WSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGP-RGFGFSLRGGKEYNMGLFIL-R 1049

Query: 283  IKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILP 334
            +     A + G +HVGD I+ I+G   +  T   A + +    ++V L + P
Sbjct: 1050 LAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRP 1101



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 23/92 (25%), Positives = 43/92 (46%), Gaps = 1/92 (1%)

Query: 599 KLKIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAER 658
           K  + K     D  +  G ++    LK+     G TI G + P + + + ++ K G A +
Sbjct: 389 KPDMEKSHFTRDPSQLKGVLV-RASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQ 447

Query: 659 TGAIHIGDRILAINSSSLKGKPLSEAIHLLQM 690
            G I  GD I+ IN + + G   ++ + + Q+
Sbjct: 448 DGKIAPGDVIVDINGNCVLGHTHADVVQMFQL 479



 Score = 30.4 bits (67), Expect = 9.4
 Identities = 22/69 (31%), Positives = 32/69 (46%), Gaps = 11/69 (15%)

Query: 162 FGFVIRGGAHDD------RNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTT 215
           FG  IRGGA         R +  P   TC    G A       PGD LL V+G  + G T
Sbjct: 29  FGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAP-----SPGDVLLEVNGTPVSGLT 83

Query: 216 HAEAMSILK 224
           + + +++++
Sbjct: 84  NRDTLAVIR 92


>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
            isoform 4 [Homo sapiens]
          Length = 2490

 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 179/819 (21%), Positives = 299/819 (36%), Gaps = 131/819 (15%)

Query: 278  IVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEIL-PHH 336
            I I  +     AD  G L  GD ++S++  S+E  +   A + L N  + V L I  P  
Sbjct: 1121 IFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKE 1180

Query: 337  QTRLALKGPDHAALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDF 396
            +       P H  L +   +    S+Y   S    +     +S   RGT+  R + +  F
Sbjct: 1181 KISKVPSTPVH--LTNEMKNYMKKSSYMQDSAIDSSSKDHHWS---RGTL--RHISENSF 1233

Query: 397  KSSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEA 456
              S  L   +  L+ Q   TE+    L+   V GF     G     E+    P  S I  
Sbjct: 1234 GPSGGLREGS--LSSQDSRTESAS--LSQSQVNGFFASHLGDQTWQESQHGSPSPSVISK 1289

Query: 457  -----------DSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQ----LLRDSSITSKV 501
                        S  ++ G+  + D   +  G    D     +SQ      ++SS +   
Sbjct: 1290 ATEKETFTDSNQSKTKKPGISDVTD--YSDRGDSDMDEATYSSSQDHQTPKQESSSSVNT 1347

Query: 502  TLEIEFDVAESVIPSSGT-FHVKLPKKHNVELGITISS-------PSSRKPGDPLVISDI 553
            + ++ F    S  P  G  F V+L K  N  LGI+++         +S + G   V + I
Sbjct: 1348 SNKMNFKTFSSSPPKPGDIFEVELAKNDN-SLGISVTVLFDKGGVNTSVRHGGIYVKAVI 1406

Query: 554  KKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDE------- 606
             +G+ A   G +  GD++LA++ + L+  + + AV+ L+    +V L + K +       
Sbjct: 1407 PQGA-AESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEH 1465

Query: 607  ----------DNSDEQESSGAIIYTVELKRY----------------GGPLGITISGTEE 640
                      D + + +    +  T ++K Y                   LG + S  + 
Sbjct: 1466 VPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDN 1525

Query: 641  PFDPIIISSLTK------GGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGET 694
                 I +S+ +      G  A  +G I +GD IL +N +SLKG    E I  L+     
Sbjct: 1526 LIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPE 1585

Query: 695  VTLKIKKQTDAQSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDMYPSTVPSVDSAV 754
            V L + +                                  PG L ++  + +  + S  
Sbjct: 1586 VFLLLCR--------------------------------PPPGVLPEIDTALLTPLQSPA 1613

Query: 755  DSWDGSAIDTSYGTQGTSFQASGYNFNTYDWRSPKQRGSLSPVTKPRSQTYPDVGLSYED 814
                 S+ D+S        Q++  + N    +S KQ  S S     R  +Y D   S ED
Sbjct: 1614 QVLPNSSKDSS--QPSCVEQSTSSDENEMSDKSKKQCKSPS-----RRDSYSDSSGSGED 1666

Query: 815  WDRSTASGFAGAADSAETEQEENFWSQALEDLETCGQSGILRELEEKADRRVSLRNMTLL 874
             D  TA   A  ++S         WS AL    +   S      E    +  ++  M   
Sbjct: 1667 -DLVTAP--ANISNST--------WSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYY 1715

Query: 875  -ATIMSGSTMSLNHEAPTPRSQLGRQASFQERSSSRPHYSQTTRSNTLPSDVGRKSVTLR 933
               I +      ++ +P P      Q S+Q +S S    S         S+  R+     
Sbjct: 1716 PQKIPNKPEFEDSNPSPLPPDMAPGQ-SYQPQSESASSSSMDKYHIHHISEPTRQE-NWT 1773

Query: 934  KMKQEIKEIMSPTPVELHKVTLYKDSDMEDFGFSVADGLLEKGVYVKNIRPAGPGDLGGL 993
             +K +++  +    +E+  +     S+    GF+V  G    G YV ++        G L
Sbjct: 1774 PLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRL 1833

Query: 994  KPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISR 1032
            KP DRL++VN     +      V L+  +   + LVI R
Sbjct: 1834 KPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR 1872



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 71/272 (26%), Positives = 106/272 (38%), Gaps = 61/272 (22%)

Query: 19   DESPYTKSASQTKPPDGALAVRRQSIPEEFK---------GSTVVELMKKEGTTLGLTVS 69
            DE+ Y+ S     P   + +    S    FK         G      + K   +LG++V+
Sbjct: 1324 DEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVT 1383

Query: 70   GGIDKDGKPRVSNLRQGGI---------AARSD-QLDVGDYIKAVNGINLAKFRHDEIIS 119
               DK G    +++R GGI         AA SD ++  GD + AVNG++L    H + + 
Sbjct: 1384 VLFDKGGVN--TSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVE 1441

Query: 120  LLKNVGERVVLEVEYELPPVSV------------------QGSSVIFRTV---------- 151
             L+N G+ V L +E    P S                   QG   + +T           
Sbjct: 1442 TLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTE 1501

Query: 152  ----EVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVR-----PGGPADREGTIKPGDR 202
                EV L K  +  GF     + +D      +  + VR     PG PA   G I  GD 
Sbjct: 1502 ENTFEVKLFKNSSGLGFSF---SREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDV 1558

Query: 203  LLSVDGIRLLGTTHAEAMSILKQCGQEAALLI 234
            +L V+G  L G +  E +S L+    E  LL+
Sbjct: 1559 ILKVNGASLKGLSQQEVISALRGTAPEVFLLL 1590



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 90/423 (21%), Positives = 165/423 (39%), Gaps = 71/423 (16%)

Query: 645  IIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTD 704
            I ISS+  GG A+  G +  GDR++++NS SL+G     AI +LQ A E VTL I     
Sbjct: 1121 IFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVI----- 1175

Query: 705  AQSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDMYPSTVPSVDSAVDSWDGSAIDT 764
            +Q      K P              S+P     ++ +    +    DSA+D    S+   
Sbjct: 1176 SQPKEKISKVP--------------STPVHLTNEMKNYMKKSSYMQDSAID----SSSKD 1217

Query: 765  SYGTQGTSFQASGYNFNTYDWRSPKQRGSLSPVTKPRSQTYPDVGLSYEDWDRSTASGFA 824
             + ++GT    S    N++      + GSLS           D         +S  +GF 
Sbjct: 1218 HHWSRGTLRHISE---NSFGPSGGLREGSLSS---------QDSRTESASLSQSQVNGFF 1265

Query: 825  GAADSAETEQEENFWSQALEDLETCGQSGILRELEEKADRRVSLRNMTLLA----TIMSG 880
             +    +T QE    S +   +    +     +  +   ++  + ++T  +    + M  
Sbjct: 1266 ASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDE 1325

Query: 881  STMSLNHEAPTPRSQLGRQASFQERSSSRPHYSQTTRSNTLPSDVGRKSVTLRKMKQEIK 940
            +T S + +  TP+    +++S    +S++ ++   + S   P D+            E++
Sbjct: 1326 ATYSSSQDHQTPK----QESSSSVNTSNKMNFKTFSSSPPKPGDI-----------FEVE 1370

Query: 941  EIMSPTPVELHKVTLYKDSDMEDFGFSVADGLLEKGVYVKNIRPAGPGDLGG-LKPYDRL 999
               +   + +    L+   D      SV  G    G+YVK + P G  +  G +   DR+
Sbjct: 1371 LAKNDNSLGISVTVLF---DKGGVNTSVRHG----GIYVKAVIPQGAAESDGRIHKGDRV 1423

Query: 1000 LQVNHVRTRDFDCCLVVPLIAESGNKLDLVISRN---------PLASQKSIDQQSLPGDW 1050
            L VN V          V  +  +G  + L++ +          P+  Q ++  Q+  G  
Sbjct: 1424 LAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQG 1483

Query: 1051 SEQ 1053
             E+
Sbjct: 1484 PEK 1486



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 31/72 (43%), Positives = 44/72 (61%), Gaps = 1/72 (1%)

Query: 163  GFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSI 222
            GF I GG    R     + I+ V PGGPAD +G +KPGDRL+SV+ + L G +H  A+ I
Sbjct: 1105 GFQIIGGEKMGR-LDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEI 1163

Query: 223  LKQCGQEAALLI 234
            L+   ++  L+I
Sbjct: 1164 LQNAPEDVTLVI 1175



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 57/224 (25%), Positives = 89/224 (39%), Gaps = 48/224 (21%)

Query: 152  EVTLHKEGNTFGFVI-----RGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSV 206
            EV L K  N+ G  +     +GG +        + +  V P G A+ +G I  GDR+L+V
Sbjct: 1368 EVELAKNDNSLGISVTVLFDKGGVNTSVRHGG-IYVKAVIPQGAAESDGRIHKGDRVLAV 1426

Query: 207  DGIRLLGTTHAEAMSILKQCGQEAALLIEYDVS--------------VMDSVATASGPLL 252
            +G+ L G TH +A+  L+  GQ   LL+E   S              + D  A   GP  
Sbjct: 1427 NGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGP-- 1484

Query: 253  VEVAKTP---------------------GASLGVALTTS-----MCCNKQVIVIDKIKSA 286
             +V KT                       + LG + +          N  ++ + K+   
Sbjct: 1485 EKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPG 1544

Query: 287  SIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKL 330
              A   G + VGD IL ++G S++  +  E    L  T  +V L
Sbjct: 1545 QPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFL 1588



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 52/194 (26%), Positives = 87/194 (44%), Gaps = 9/194 (4%)

Query: 190  PADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASG 249
            PA  +G +KPGDRL+ V+   +   TH +A+++L+   +   L+I     V++       
Sbjct: 1826 PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIG---RVLELPRIPML 1882

Query: 250  P-LLVEVAKTPG-ASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGT 307
            P LL ++  T     LG +L        QV+ I  I   S+A   G L + D I  ++G 
Sbjct: 1883 PHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGV 1942

Query: 308  SMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHAALVSSSFSPTSMSAYSLSS 367
            S +  TL E  + L  +   +   +L   +  L +      + VS+  S     +YS+ S
Sbjct: 1943 STQGMTLEEVNRALDMSLPSL---VLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGS 1999

Query: 368  LNMGTL-PRSLYST 380
             +   L P   +ST
Sbjct: 2000 CSQPALTPNDSFST 2013



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 31/96 (32%), Positives = 48/96 (50%), Gaps = 6/96 (6%)

Query: 942  IMSPTPVELHKVTLYKDSDMEDFGFSVADG----LLEKGVYVKNIRPAGPGDLGG-LKPY 996
            I+S    E+  V L KD+     GF +  G     L+ G+++ ++ P GP DL G LKP 
Sbjct: 1083 IVSSPEREITLVNLKKDAKY-GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPG 1141

Query: 997  DRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISR 1032
            DRL+ VN V          + ++  +   + LVIS+
Sbjct: 1142 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQ 1177



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 51/220 (23%), Positives = 93/220 (42%), Gaps = 11/220 (5%)

Query: 522  VKLPKKHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDN 581
            + L K     LG T++  + R       + D+ +   A   G L+ GD+L+ +++  + N
Sbjct: 1794 ITLIKSEKGSLGFTVTKGNQRIG---CYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTN 1849

Query: 582  CSMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEP 641
             +  DAV +L+     V+L I +  +          ++  + L      LG ++ G  + 
Sbjct: 1850 MTHTDAVNLLRAASKTVRLVIGRVLE-LPRIPMLPHLLPDITLTCNKEELGFSLCGGHDS 1908

Query: 642  -FDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIK 700
             +  + IS +    +A   G + + D I  +N  S +G  L E    L M+  ++ LK  
Sbjct: 1909 LYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKAT 1968

Query: 701  KQTDAQSASSPKKFPISSHLSDLGD----VEEDSSPAQKP 736
            +  D     S K+  +S+  S  G+    V   S PA  P
Sbjct: 1969 R-NDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTP 2007



 Score = 38.9 bits (89), Expect = 0.026
 Identities = 39/144 (27%), Positives = 67/144 (46%), Gaps = 10/144 (6%)

Query: 26   SASQTKPPDGALAVRRQSI---PEEFKGSTVVELMKKEGTTLGLTVSGGIDKDGKPR--- 79
            S+SQ    +  +  +R SI   PE  +  T+V L K     LG  + GG +K G+     
Sbjct: 1065 SSSQVPLKENDVLHKRWSIVSSPE--REITLVNLKKDAKYGLGFQIIGG-EKMGRLDLGI 1121

Query: 80   -VSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEYELPP 138
             +S++  GG A     L  GD + +VN ++L    H   I +L+N  E V L +      
Sbjct: 1122 FISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEK 1181

Query: 139  VSVQGSSVIFRTVEVTLHKEGNTF 162
            +S   S+ +  T E+  + + +++
Sbjct: 1182 ISKVPSTPVHLTNEMKNYMKKSSY 1205



 Score = 35.4 bits (80), Expect = 0.29
 Identities = 33/98 (33%), Positives = 45/98 (45%), Gaps = 5/98 (5%)

Query: 451  ISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVA 510
            IS I   S A   G LQ+ D +  +NG+ T+  T EE ++ L D S+ S V      D+ 
Sbjct: 1915 ISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRAL-DMSLPSLVLKATRNDL- 1972

Query: 511  ESVIPSSGTFHVKLPK--KHNVELGITISSPSSRKPGD 546
              V+PSS    V  PK  K N    +   S  +  P D
Sbjct: 1973 -PVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPND 2009


>gi|24025688 ligand of numb-protein X 2 [Homo sapiens]
          Length = 690

 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 56/190 (29%), Positives = 91/190 (47%), Gaps = 12/190 (6%)

Query: 530 VELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQ 589
           ++LGI+I    +  P   +VI ++ +  V  R G L  GD++L ++N  + N S   A  
Sbjct: 243 IQLGISIVG-GNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARA 301

Query: 590 ILQQCEDLVKLKIRKDE------DNSDEQESSGAIIYTVELKRY--GGPLGIT-ISGTEE 640
           +L Q  + + L + ++        N  +  S    I+ V L +   G  LGI  +  T+E
Sbjct: 302 VLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDE 361

Query: 641 PFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIK 700
           P   + I  L +GGLA + G +   DR+LAIN   LK      A  ++Q +GE V L I 
Sbjct: 362 P--GVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIA 419

Query: 701 KQTDAQSASS 710
           +    Q  ++
Sbjct: 420 RPGKPQPGNT 429



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 57/214 (26%), Positives = 100/214 (46%), Gaps = 34/214 (15%)

Query: 54  VELMKKE-GTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKF 112
           V L K++ G  LG+ +    D+ G   + +L +GG+AA+  +L   D + A+NG +L   
Sbjct: 340 VALHKRDSGEQLGIKLVRRTDEPGV-FILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYG 398

Query: 113 RHDEIISLLKNVGERVVLEV-----------------------EYELPPVSVQGSS---- 145
             +    +++  GERV L +                        +  PP   + SS    
Sbjct: 399 TPELAAQIIQASGERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDL 458

Query: 146 ---VIFRTVEVTLHKEGN-TFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGD 201
              V  +   +T+ KE + + G  + GG    ++   P+ +T V P G   R+G IK GD
Sbjct: 459 TQCVTCQEKHITVKKEPHESLGMTVAGG-RGSKSGELPIFVTSVPPHGCLARDGRIKRGD 517

Query: 202 RLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIE 235
            LL+++GI L   +H+EA+++LK      A+ ++
Sbjct: 518 VLLNINGIDLTNLSHSEAVAMLKASAASPAVALK 551



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 55/218 (25%), Positives = 103/218 (47%), Gaps = 41/218 (18%)

Query: 54  VELMKKEGTTLGLTVSGGI-DKDGKPR--VSNLRQGGIAARSDQLDVGDYIKAVNGINLA 110
           + + K+   +LG+TV+GG   K G+    V+++   G  AR  ++  GD +  +NGI+L 
Sbjct: 469 ITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLT 528

Query: 111 KFRHDEIISLLK-----------------------NVGER--VVLEVEYELPPVSVQGSS 145
              H E +++LK                       N  E+     E EY+    S   S 
Sbjct: 529 NLSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYD---ASWSPSW 585

Query: 146 VIFRTVEVTLHKEGN---------TFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGT 196
           V++  +  TLH   +         ++GF I GG +++ + ++P  I  +  G PA  +G 
Sbjct: 586 VMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGG-YEENHTNQPFFIKTIVLGTPAYYDGR 644

Query: 197 IKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLI 234
           +K GD +++V+G+  +G +H+  + +LK+   +  L +
Sbjct: 645 LKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTV 682



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 78/326 (23%), Positives = 132/326 (40%), Gaps = 49/326 (15%)

Query: 418 TTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAING 477
           TT  +  ++P    GI + G     ET     +I  +  D    R G L  GD+++ +N 
Sbjct: 232 TTIEIHRSNPYIQLGISIVGG---NETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNN 288

Query: 478 IPTEDSTFEEASQLLRDSSITSKVTLEIE-------FDVAESVIPSSGTFHVKLPKKHNV 530
               + +   A  +L     T  +T+  E        + ++S  P    F V L K+ + 
Sbjct: 289 YNISNVSHNYARAVLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSG 348

Query: 531 E-LGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQ 589
           E LGI +   +  +PG  + I D+ +G +A + G L   D++LAI+   L   + E A Q
Sbjct: 349 EQLGIKLVRRTD-EPG--VFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQ 405

Query: 590 ILQQCEDLVKLKIRKD-------------EDNSDEQESSGAIIYT--------------- 621
           I+Q   + V L I +                +S  Q  +    Y+               
Sbjct: 406 IIQASGERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQ 465

Query: 622 ----VELKRYGGPLGITISG---TEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSS 674
                  K     LG+T++G   ++    PI ++S+   G   R G I  GD +L IN  
Sbjct: 466 EKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGI 525

Query: 675 SLKGKPLSEAIHLLQMAGETVTLKIK 700
            L     SEA+ +L+ +  +  + +K
Sbjct: 526 DLTNLSHSEAVAMLKASAASPAVALK 551



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 73/308 (23%), Positives = 123/308 (39%), Gaps = 68/308 (22%)

Query: 460 AERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTL------EIEFDVAESV 513
           A + G L   DRV+AING   +  T E A+Q+++ S     +T+      +    + E+ 
Sbjct: 375 AAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGNTIREAG 434

Query: 514 IPSSGTFH--------------------------VKLPKKHNVELGITISSPSSRKPGD- 546
             SS + H                          + + K+ +  LG+T++     K G+ 
Sbjct: 435 NHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGEL 494

Query: 547 PLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQ--CEDLVKLK--- 601
           P+ ++ +       R G ++ GD LL I+ I L N S  +AV +L+       V LK   
Sbjct: 495 PIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKALE 554

Query: 602 ---IRKDEDNSDEQESSGA-----------------------IIYTVELKR-YGGPLGIT 634
              + +   N++EQ S+ +                         + + L+R Y G  G +
Sbjct: 555 VQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLGLPSTLHSCHDIVLRRSYLGSWGFS 614

Query: 635 ISGTEEPF---DPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMA 691
           I G  E      P  I ++  G  A   G +  GD I+A+N  S  G   S  + +L+  
Sbjct: 615 IVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQ 674

Query: 692 GETVTLKI 699
              VTL +
Sbjct: 675 RNKVTLTV 682



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 91/464 (19%), Positives = 172/464 (37%), Gaps = 82/464 (17%)

Query: 180 VVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVS 239
           +VI  V   G   R+G +  GD++L V+   +   +H  A ++L Q      L +  +  
Sbjct: 260 IVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLHLTVLRERR 319

Query: 240 VMD-----SVATASGPLLVEVA---KTPGASLGVALTTSMCCNKQVIVIDKIKSASIADR 291
             +     S + +    + +VA   +  G  LG+ L      ++  + I  +    +A +
Sbjct: 320 FGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRR--TDEPGVFILDLLEGGLAAQ 377

Query: 292 CGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHAALV 351
            G L   D +L+I+G  ++Y T   A Q +  + ++V L I      R     P +    
Sbjct: 378 DGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTI-----ARPGKPQPGN---- 428

Query: 352 SSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAG 411
                 T   A + SS +    P   YS         R    KD                
Sbjct: 429 ------TIREAGNHSSSSQHHTPPPYYS---------RPSSHKDLT-------------- 459

Query: 412 QVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDR 471
           Q V  +   + +  +P    G+ + G    +++   P  ++ +       R G ++ GD 
Sbjct: 460 QCVTCQEKHITVKKEPHESLGMTVAGG-RGSKSGELPIFVTSVPPHGCLARDGRIKRGDV 518

Query: 472 VMAINGIPTEDSTFEEASQLLRDSSITSKVTLE-IEFDVAESVIPSS------------- 517
           ++ INGI   + +  EA  +L+ S+ +  V L+ +E  + E    ++             
Sbjct: 519 LLNINGIDLTNLSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYD 578

Query: 518 --------------GTFH----VKLPKKHNVELGITI-SSPSSRKPGDPLVISDIKKGSV 558
                          T H    + L + +    G +I           P  I  I  G+ 
Sbjct: 579 ASWSPSWVMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTP 638

Query: 559 AHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKI 602
           A+  G L+ GD ++A++ +     S    V +L++  + V L +
Sbjct: 639 AYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTV 682



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 32/136 (23%), Positives = 57/136 (41%), Gaps = 6/136 (4%)

Query: 3   AVSFKC-RCQILRRLTK--DESPYTKSASQTKPPDGALAVRRQSIPEEFKGSTVVELMKK 59
           AV+ K    QI+   T+  +E P T S ++         V    +P        + L + 
Sbjct: 547 AVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLGLPSTLHSCHDIVLRRS 606

Query: 60  EGTTLGLTVSGGIDKDGKPR---VSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDE 116
              + G ++ GG +++   +   +  +  G  A    +L  GD I AVNG++     H  
Sbjct: 607 YLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSA 666

Query: 117 IISLLKNVGERVVLEV 132
           ++ +LK    +V L V
Sbjct: 667 LVPMLKEQRNKVTLTV 682



 Score = 32.0 bits (71), Expect = 3.2
 Identities = 23/85 (27%), Positives = 39/85 (45%), Gaps = 1/85 (1%)

Query: 949  ELHKVTLYKDSDMEDFGFSVADGLLEKGVYVKNIRPAG-PGDLGGLKPYDRLLQVNHVRT 1007
            E+ +V L+K    E  G  +     E GV++ ++   G     G L   DR+L +N    
Sbjct: 336  EIFQVALHKRDSGEQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDL 395

Query: 1008 RDFDCCLVVPLIAESGNKLDLVISR 1032
            +     L   +I  SG +++L I+R
Sbjct: 396  KYGTPELAAQIIQASGERVNLTIAR 420


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.130    0.367 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,205,455
Number of Sequences: 37866
Number of extensions: 1814058
Number of successful extensions: 5988
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 156
Number of HSP's successfully gapped in prelim test: 95
Number of HSP's that attempted gapping in prelim test: 4276
Number of HSP's gapped (non-prelim): 1530
length of query: 1076
length of database: 18,247,518
effective HSP length: 113
effective length of query: 963
effective length of database: 13,968,660
effective search space: 13451819580
effective search space used: 13451819580
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.