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Search of human proteins with 223671861
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|223671861 complement factor properdin precursor [Homo
sapiens]
(469 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505737 complement factor properdin precursor [Homo sapiens] 1066 0.0
gi|223671861 complement factor properdin precursor [Homo sapiens] 1066 0.0
gi|118572606 hemicentin 1 [Homo sapiens] 233 4e-61
gi|147904700 semaphorin 5A [Homo sapiens] 183 3e-46
gi|91982767 semaphorin 5B isoform 1 [Homo sapiens] 176 4e-44
gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [... 172 6e-43
gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens] 171 2e-42
gi|40317626 thrombospondin 1 precursor [Homo sapiens] 156 3e-38
gi|115387099 brain-specific angiogenesis inhibitor 2 [Homo sapiens] 152 6e-37
gi|134031945 SCO-spondin [Homo sapiens] 151 1e-36
gi|40317628 thrombospondin 2 precursor [Homo sapiens] 149 5e-36
gi|32261318 unc-5 homolog B [Homo sapiens] 103 4e-22
gi|110347423 spondin 1, extracellular matrix protein [Homo sapiens] 102 6e-22
gi|16933525 unc5C [Homo sapiens] 95 1e-19
gi|209977117 unc-5 homolog D [Homo sapiens] 94 2e-19
gi|150170672 thrombospondin, type I, domain containing 7A [Homo ... 92 8e-19
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 86 7e-17
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 84 3e-16
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 83 6e-16
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 79 9e-15
gi|122937257 thrombospondin, type I, domain containing 7B [Homo ... 77 4e-14
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 75 1e-13
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 74 2e-13
gi|145309328 papilin [Homo sapiens] 72 1e-12
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 71 2e-12
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 71 2e-12
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 70 5e-12
gi|223718260 ADAMTS-like 2 precursor [Homo sapiens] 69 9e-12
gi|41281450 ADAMTS-like 2 precursor [Homo sapiens] 69 9e-12
gi|169174934 PREDICTED: similar to ADAMTS-like 2 [Homo sapiens] 69 9e-12
>gi|4505737 complement factor properdin precursor [Homo sapiens]
Length = 469
Score = 1066 bits (2758), Expect = 0.0
Identities = 469/469 (100%), Positives = 469/469 (100%)
Query: 1 MITEGAQAPRLLLPPLLLLLTLPATGSDPVLCFTQYEESSGKCKGLLGGGVSVEDCCLNT 60
MITEGAQAPRLLLPPLLLLLTLPATGSDPVLCFTQYEESSGKCKGLLGGGVSVEDCCLNT
Sbjct: 1 MITEGAQAPRLLLPPLLLLLTLPATGSDPVLCFTQYEESSGKCKGLLGGGVSVEDCCLNT 60
Query: 61 AFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTL 120
AFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTL
Sbjct: 61 AFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTL 120
Query: 121 EWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQE 180
EWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQE
Sbjct: 121 EWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQE 180
Query: 181 SEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPG 240
SEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPG
Sbjct: 181 SEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPG 240
Query: 241 LAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDA 300
LAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDA
Sbjct: 241 LAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDA 300
Query: 301 TRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRC 360
TRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRC
Sbjct: 301 TRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRC 360
Query: 361 AGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSM 420
AGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSM
Sbjct: 361 AGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSM 420
Query: 421 VEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEEEEL 469
VEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEEEEL
Sbjct: 421 VEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEEEEL 469
>gi|223671861 complement factor properdin precursor [Homo sapiens]
Length = 469
Score = 1066 bits (2758), Expect = 0.0
Identities = 469/469 (100%), Positives = 469/469 (100%)
Query: 1 MITEGAQAPRLLLPPLLLLLTLPATGSDPVLCFTQYEESSGKCKGLLGGGVSVEDCCLNT 60
MITEGAQAPRLLLPPLLLLLTLPATGSDPVLCFTQYEESSGKCKGLLGGGVSVEDCCLNT
Sbjct: 1 MITEGAQAPRLLLPPLLLLLTLPATGSDPVLCFTQYEESSGKCKGLLGGGVSVEDCCLNT 60
Query: 61 AFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTL 120
AFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTL
Sbjct: 61 AFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTL 120
Query: 121 EWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQE 180
EWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQE
Sbjct: 121 EWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQE 180
Query: 181 SEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPG 240
SEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPG
Sbjct: 181 SEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPG 240
Query: 241 LAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDA 300
LAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDA
Sbjct: 241 LAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDA 300
Query: 301 TRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRC 360
TRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRC
Sbjct: 301 TRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRC 360
Query: 361 AGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSM 420
AGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSM
Sbjct: 361 AGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSM 420
Query: 421 VEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEEEEL 469
VEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEEEEL
Sbjct: 421 VEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEEEEL 469
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 233 bits (593), Expect = 4e-61
Identities = 125/336 (37%), Positives = 166/336 (49%), Gaps = 24/336 (7%)
Query: 80 WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGW 139
+S WS W CSVTC +G Q R R C GK G+ + +++ C+++ C P G W
Sbjct: 4532 FSQWSAWRACSVTCGKGIQKRSRLCNQPLPANGGKPCQGS-DLEMRNCQNKPC-PVDGSW 4589
Query: 140 SGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGH-CPGQAQESEACDTQQVCPTHGAWAT 198
S W WE C+ +C +G +TR R CN+P+ + GG C G A E C+ + CP HGAW+
Sbjct: 4590 SEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRP-CPVHGAWSA 4648
Query: 199 WGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAG 258
W PW CS SC G +TR+R C+ P P+ G C G + + C CP+ G
Sbjct: 4649 WQPWGTCSESCGKG----TQTRARLCNNPPPAF--GGSYCDGAETQMQVCNE-RNCPIHG 4701
Query: 259 GWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEW 318
W W S C V+CG G R C+ PVPQ+GG C G ++ CN+ PCP G W
Sbjct: 4702 KWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGSDVQSDFCNSD-PCPTHGNW 4760
Query: 319 DSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRG--RKFDGHRCAGQQQDIRHCYSIQHC 376
W W C R +C GQ R RTC G C G I+ C + C
Sbjct: 4761 SPWSGWGTCSR------TCN--GGQMRRYRTCDNPPPSNGGRACGGPDSQIQRC-NTDMC 4811
Query: 377 PLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLP 412
P+ GSW W +W C CG + R+RLC +P
Sbjct: 4812 PVDGSWGSWHSWSQCSASCG-GGEKTRKRLCDHPVP 4846
Score = 219 bits (558), Expect = 4e-57
Identities = 117/305 (38%), Positives = 151/305 (49%), Gaps = 31/305 (10%)
Query: 80 WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGW 139
WS WS W C+ +C G+Q R R C + Q G+ G ++ C + C P G W
Sbjct: 4589 WSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAV-EIIMCNIRPC-PVHGAW 4646
Query: 140 SGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGG-HCPGQAQESEACDTQQVCPTHGAWAT 198
S W PW CS +C KGT+TR R CN+P P GG +C G + + C+ + CP HG WAT
Sbjct: 4647 SAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERN-CPIHGKWAT 4705
Query: 199 WGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAG 258
W W+ CS SC GG + R+R CS P P G+ C G + C PCP G
Sbjct: 4706 WASWSACSVSCGGGARQ----RTRGCSDPVPQY--GGRKCEGSDVQSDFCNS-DPCPTHG 4758
Query: 259 GWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEW 318
W PW C TC GQ RTC++P P +GG C G ++ CNT + CPVDG W
Sbjct: 4759 NWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQRCNTDM-CPVDGSW 4817
Query: 319 DSWGEWSPCIRRNMKSISCQEIPGQQSRGRTC------RGRKFDGHRCAGQQQDIRHCYS 372
SW WS C S SC G+++R R C +G G C G + C +
Sbjct: 4818 GSWHSWSQC------SASCG--GGEKTRKRLCDHPVPVKG----GRPCPGDTTQVTRC-N 4864
Query: 373 IQHCP 377
+Q CP
Sbjct: 4865 VQACP 4869
Score = 205 bits (521), Expect = 8e-53
Identities = 105/272 (38%), Positives = 133/272 (48%), Gaps = 18/272 (6%)
Query: 137 GGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGH-CPGQAQESEACDTQQVCPTHGA 195
GG+S W W CSVTC KG + R R CN P P GG C G E C + CP G+
Sbjct: 4530 GGFSQWSAWRACSVTCGKGIQKRSRLCNQPLPANGGKPCQGSDLEMRNCQNKP-CPVDGS 4588
Query: 196 WATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCP 255
W+ W W C+ SC G +TR+R C+ PS + G+PC G A E C + PCP
Sbjct: 4589 WSEWSLWEECTRSCGRG----NQTRTRTCN--NPSVQHGGRPCEGNAVEIIMC-NIRPCP 4641
Query: 256 VAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVD 315
V G W W P C +CG G R CN+P P GG +C G T+ +CN CP+
Sbjct: 4642 VHGAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNER-NCPIH 4700
Query: 316 GEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQH 375
G+W +W WS C S+SC Q++RG + ++ G +C G C S
Sbjct: 4701 GKWATWASWSAC------SVSCGGGARQRTRGCSDPVPQYGGRKCEGSDVQSDFCNS-DP 4753
Query: 376 CPLKGSWSEWSTWGLCMPPCGPNPTRARQRLC 407
CP G+WS WS WG C C R R R C
Sbjct: 4754 CPTHGNWSPWSGWGTCSRTCNGGQMR-RYRTC 4784
Score = 159 bits (402), Expect = 5e-39
Identities = 84/228 (36%), Positives = 111/228 (48%), Gaps = 20/228 (8%)
Query: 189 VCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRC 248
+ HG ++ W W CS +C G + RSR C+ P P+ GKPC G E R C
Sbjct: 4525 IVQVHGGFSQWSAWRACSVTCGKGIQK----RSRLCNQPLPANG--GKPCQGSDLEMRNC 4578
Query: 249 TGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNT 308
PCPV G W W C +CG G RTCN+P QHGG C G+A +CN
Sbjct: 4579 QN-KPCPVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNI 4637
Query: 309 AVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRG--RKFDGHRCAGQQQD 366
PCPV G W +W W C S SC + G Q+R R C F G C G +
Sbjct: 4638 R-PCPVHGAWSAWQPWGTC------SESCGK--GTQTRARLCNNPPPAFGGSYCDGAETQ 4688
Query: 367 IRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKY 414
++ C + ++CP+ G W+ W++W C CG R R R C+ +P+Y
Sbjct: 4689 MQVC-NERNCPIHGKWATWASWSACSVSCG-GGARQRTRGCSDPVPQY 4734
Score = 132 bits (332), Expect = 7e-31
Identities = 67/178 (37%), Positives = 94/178 (52%), Gaps = 11/178 (6%)
Query: 79 RWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGG 138
+W+ W++W+ CSV+C G++ R R C Q G+ G+ + Q C CP G
Sbjct: 4702 KWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGS-DVQSDFCNSDP-CPTHGN 4759
Query: 139 WSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGH-CPGQAQESEACDTQQVCPTHGAWA 197
WS W W CS TC+ G R R C++P P GG C G + + C+T +CP G+W
Sbjct: 4760 WSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQRCNT-DMCPVDGSWG 4818
Query: 198 TWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCP 255
+W W+ CSASC GG ++TR R C P P + G+PCPG + RC + CP
Sbjct: 4819 SWHSWSQCSASCGGG----EKTRKRLCDHPVPVK--GGRPCPGDTTQVTRC-NVQACP 4869
>gi|147904700 semaphorin 5A [Homo sapiens]
Length = 1074
Score = 183 bits (465), Expect = 3e-46
Identities = 113/355 (31%), Positives = 153/355 (43%), Gaps = 41/355 (11%)
Query: 76 RSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPE 135
R+ W+ W++W+PCS TC G Q+R R C + G+V G + + C + CP
Sbjct: 594 RNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQ-NREERYCNEHLLCPP 652
Query: 136 MGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGA 195
W+GWGPWE C+ C G + RRR C + G C G E ++C+T CP
Sbjct: 653 HMFWTGWGPWERCTAQCGGGIQARRRICEN-----GPDCAGCNVEYQSCNTNP-CPELKK 706
Query: 196 WATWGPWTPCSASCHGGPHEPKETRSRKCSAPEP----------------SQKPPGKPCP 239
W PWTP + S +GG +E + + K +P S G
Sbjct: 707 TTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDGTSGCSTD 766
Query: 240 GLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGD 299
GL+ + R V G W W S C C G +R CN+P P++GG C G
Sbjct: 767 GLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGP 826
Query: 300 ATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCR--GRKFDG 357
+ CN +PCPVDG W W W+ C S +C G R R+C + G
Sbjct: 827 SLEYQECN-ILPCPVDGVWSCWSPWTKC------SATCG--GGHYMRTRSCSNPAPAYGG 877
Query: 358 HRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLP 412
C G + C + Q CP SWSEWS W C + + R R C L P
Sbjct: 878 DICLGLHTEEALC-NTQPCP--ESWSEWSDWS----ECEASGVQVRARQCILLFP 925
Score = 160 bits (404), Expect = 3e-39
Identities = 113/366 (30%), Positives = 152/366 (41%), Gaps = 64/366 (17%)
Query: 80 WSLWSTWAPCSVT--CSEGSQL-RYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQC-CPE 135
+ +WS W PC+ T + GS L R R C QC G WQ + + C
Sbjct: 543 FGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGG--------WQCEGPGMEIANCSR 594
Query: 136 MGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGH-CPGQAQESEACDTQQVCPTHG 194
GGW+ W W PCS TC G + R+R+C++P P+ GG C GQ +E C+ +CP H
Sbjct: 595 NGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLLCPPHM 654
Query: 195 AWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPC 254
W WGPW C+A C GG + R R C G C G E + C PC
Sbjct: 655 FWTGWGPWERCTAQCGGG----IQARRRICE--------NGPDCAGCNVEYQSC-NTNPC 701
Query: 255 PVAGGWGPWGPVSPCPVTCGLGQ-------TMEQRTCNHPVPQHGGP-----FCAGDATR 302
P PW P +P ++ G T + R + + + G +C+ D T
Sbjct: 702 PELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDGTS 761
Query: 303 THICNT------------AVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTC 350
C+T V+G W +W WS C R C G ++R R C
Sbjct: 762 G--CSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSR------DCSR--GIRNRKRVC 811
Query: 351 RG--RKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCT 408
K+ G C G + + C +I CP+ G WS WS W C CG R R C+
Sbjct: 812 NNPEPKYGGMPCLGPSLEYQEC-NILPCPVDGVWSCWSPWTKCSATCG-GGHYMRTRSCS 869
Query: 409 PLLPKY 414
P Y
Sbjct: 870 NPAPAY 875
Score = 135 bits (340), Expect = 8e-32
Identities = 91/314 (28%), Positives = 122/314 (38%), Gaps = 41/314 (13%)
Query: 121 EWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRT---RRRACNHPAPKCGG-HCPG 176
E + AC + + G + W PW PC+ T + R R+C+ PAP+CGG C G
Sbjct: 526 EQSISACPTRNLTVD-GHFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEG 584
Query: 177 QAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGK 236
E C +G W W W+PCS +C G + R R CS P P + G+
Sbjct: 585 PGMEIANCS------RNGGWTPWTSWSPCSTTCGIG----FQVRQRSCSNPTP--RHGGR 632
Query: 237 PCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFC 296
C G E+R C CP W WGP C CG G +R C + GP C
Sbjct: 633 VCVGQNREERYCNEHLLCPPHMFWTGWGPWERCTAQCGGGIQARRRICEN------GPDC 686
Query: 297 AGDATRTHICNTAVPCPVDGEWDSWGEWSP----------------CIRRNMKSISCQEI 340
AG CNT PCP + W W+P + + + E+
Sbjct: 687 AGCNVEYQSCNTN-PCPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEV 745
Query: 341 PGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPT 400
Q+ R C G G D + G+WS W++W C C
Sbjct: 746 GRQRIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCS-RGI 804
Query: 401 RARQRLCTPLLPKY 414
R R+R+C PKY
Sbjct: 805 RNRKRVCNNPEPKY 818
Score = 102 bits (254), Expect = 7e-22
Identities = 62/174 (35%), Positives = 79/174 (45%), Gaps = 25/174 (14%)
Query: 80 WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQC----CPE 135
WS W++W+ CS CS G + R R C + G G + E Q+C CP
Sbjct: 787 WSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGP------SLEYQECNILPCPV 840
Query: 136 MGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGH-CPGQAQESEACDTQQVCPTHG 194
G WS W PW CS TC G R R+C++PAP GG C G E C+TQ CP
Sbjct: 841 DGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQP-CPE-- 897
Query: 195 AWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRC 248
+W+ W W+ C AS + R+R+C P G C G E R C
Sbjct: 898 SWSEWSDWSECEAS-------GVQVRARQCIL----LFPMGSQCSGNTTESRPC 940
>gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]
Length = 1151
Score = 176 bits (446), Expect = 4e-44
Identities = 117/389 (30%), Positives = 160/389 (41%), Gaps = 57/389 (14%)
Query: 42 KCKGL--LGGGVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQL 99
+C GL LG + + +C N A W+ WS+WA CS +C G Q+
Sbjct: 645 RCGGLDCLGPAIHIANCSRNGA------------------WTPWSSWALCSTSCGIGFQV 686
Query: 100 RYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTR 159
R R C + G++ G + + C + CP W+ WG W CS C G ++R
Sbjct: 687 RQRSCSNPAPRHGGRICVGKSREE-RFCNENTPCPVPIFWASWGSWSKCSSNCGGGMQSR 745
Query: 160 RRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKET 219
RRAC + G C G E + C+ + CP W PW P + + G E +
Sbjct: 746 RRACEN-----GNSCLGCGVEFKTCNPEG-CPEVRRNTPWTPWLPVNVTQGGARQEQRFR 799
Query: 220 RSRKCSAPEPS------QKPPGKPCPG----------LAYEQRRCTGLPPCPVAGGWGPW 263
+ + +P ++ + CP L R P V+GGW W
Sbjct: 800 FTCRAPLADPHGLQFGRRRTETRTCPADGSGSCDTDALVEVLLRSGSTSPHTVSGGWAAW 859
Query: 264 GPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGE 323
GP S C C LG + +RTC +P P++GG C GDA CN CPV G W W
Sbjct: 860 GPWSSCSRDCELGFRVRKRTCTNPEPRNGGLPCVGDAAEYQDCNPQA-CPVRGAWSCWTS 918
Query: 324 WSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWS 383
WSPC S SC Q++R T C G + C + Q CP WS
Sbjct: 919 WSPC------SASCGGGHYQRTRSCTSPAPSPGEDICLGLHTEEALC-ATQACP--EGWS 969
Query: 384 EWSTWGLCMPPCGPNPTRARQRLCTPLLP 412
WS W C + ++R R C LLP
Sbjct: 970 PWSEWS----KCTDDGAQSRSRHCEELLP 994
Score = 148 bits (374), Expect = 9e-36
Identities = 103/323 (31%), Positives = 123/323 (38%), Gaps = 57/323 (17%)
Query: 74 PCRSPR-WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQC 132
PC P W+ W +W+ CS C G Q R R C N C G + + C + C
Sbjct: 718 PCPVPIFWASWGSWSKCSSNCGGGMQSRRRACENGNS-CLGCGV------EFKTCNPEGC 770
Query: 133 CPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGH-------------CPGQAQ 179
PE+ + W PW P +VT + +R AP H CP A
Sbjct: 771 -PEVRRNTPWTPWLPVNVTQGGARQEQRFRFTCRAPLADPHGLQFGRRRTETRTCP--AD 827
Query: 180 ESEACDTQQVCPT------------HGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAP 227
S +CDT + G WA WGPW+ CS C G R R C+ P
Sbjct: 828 GSGSCDTDALVEVLLRSGSTSPHTVSGGWAAWGPWSSCSRDCELG----FRVRKRTCTNP 883
Query: 228 EPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHP 287
EP + G PC G A E + C CPV G W W SPC +CG G R+C P
Sbjct: 884 EP--RNGGLPCVGDAAEYQDCNP-QACPVRGAWSCWTSWSPCSASCGGGHYQRTRSCTSP 940
Query: 288 VPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRG 347
P G C G T +C T CP W W EWS C G QSR
Sbjct: 941 APSPGEDICLGLHTEEALCATQA-CPEG--WSPWSEWSKCTD-----------DGAQSRS 986
Query: 348 RTCRGRKFDGHRCAGQQQDIRHC 370
R C CAG R C
Sbjct: 987 RHCEELLPGSSACAGNSSQSRPC 1009
Score = 119 bits (297), Expect = 8e-27
Identities = 102/359 (28%), Positives = 137/359 (38%), Gaps = 62/359 (17%)
Query: 89 CSVTCSEGSQLRYRR-CVGWNGQ---CSGKVAPGTLE-W--QLQACEDQQCCPEMGGWSG 141
C+ S+G+ L R GW+G+ CS + W + AC + + GG+
Sbjct: 556 CAAYRSQGACLGARDPYCGWDGKQQRCSTLEDSSNMSLWTQNITACPVRNVTRD-GGFGP 614
Query: 142 WGPWEPCSVTCSKGTRT---RRRACNHPAPKCGG-HCPGQAQESEACDTQQVCPTHGAWA 197
W PW+PC + + R R+C+ P P+CGG C G A C +GAW
Sbjct: 615 WSPWQPCEHLDGDNSGSCLCRARSCDSPRPRCGGLDCLGPAIHIANCS------RNGAWT 668
Query: 198 TWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVA 257
W W CS SC G + R R CS P P + G+ C G + E+R C PCPV
Sbjct: 669 PWSSWALCSTSCGIG----FQVRQRSCSNPAP--RHGGRICVGKSREERFCNENTPCPVP 722
Query: 258 GGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGE 317
W WG S C CG G +R C + G C G CN CP
Sbjct: 723 IFWASWGSWSKCSSNCGGGMQSRRRACEN------GNSCLGCGVEFKTCNPE-GCPEVRR 775
Query: 318 WDSWGEWSPCIRRNMKSISCQEIPGQQSRGR-TCRGRKFDGH--RCAGQQQDIRHC---- 370
W W P N+ + Q+ R R TCR D H + ++ + R C
Sbjct: 776 NTPWTPWLPV---NVTQGGAR----QEQRFRFTCRAPLADPHGLQFGRRRTETRTCPADG 828
Query: 371 ----------------YSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPK 413
S + G W+ W W C C R R+R CT P+
Sbjct: 829 SGSCDTDALVEVLLRSGSTSPHTVSGGWAAWGPWSSCSRDCELG-FRVRKRTCTNPEPR 886
Score = 30.0 bits (66), Expect = 4.7
Identities = 25/87 (28%), Positives = 31/87 (35%), Gaps = 26/87 (29%)
Query: 32 CFTQYEESSGKCKGLLGGG-------------VSVEDCCLNTAFAYQKRSGGLCQPCRSP 78
C+T + S C GGG ED CL LC P
Sbjct: 915 CWTSWSPCSASC----GGGHYQRTRSCTSPAPSPGEDICLGL-----HTEEALCATQACP 965
Query: 79 R-WSLWSTWAPCSVTCSEGSQLRYRRC 104
WS WS W+ C+ +G+Q R R C
Sbjct: 966 EGWSPWSEWSKCT---DDGAQSRSRHC 989
>gi|111118994 brain-specific angiogenesis inhibitor 1 precursor
[Homo sapiens]
Length = 1584
Score = 172 bits (436), Expect = 6e-43
Identities = 108/337 (32%), Positives = 136/337 (40%), Gaps = 64/337 (18%)
Query: 80 WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCP----- 134
W LWS W C+ C G Q R R C+ G G G LE + + C + C P
Sbjct: 264 WKLWSLWGECTRDCGGGLQTRTRTCLPAPG-VEGGGCEGVLE-EGRQCNREACGPAGRTS 321
Query: 135 ---------------EMG----------------GWSGWGPWEPCSVTCSKGTRTRRRAC 163
E+G W PW CS TC +G +TR R C
Sbjct: 322 SRSQSLRSTDARRREELGDELQQFGFPAPQTGDPAAEEWSPWSVCSSTCGEGWQTRTRFC 381
Query: 164 NHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRK 223
+ C G +E C+ VCP HGAW W PW+ CS++C G + R+R
Sbjct: 382 --VSSSYSTQCSGPLREQRLCNNSAVCPVHGAWDEWSPWSLCSSTCGRGFRD----RTRT 435
Query: 224 CSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCP---VAGGWGPWGPVSPCPVTCGLGQTME 280
C P+ G PC G + + C + CP V G W W S C +C G+
Sbjct: 436 CRPPQFG----GNPCEGPEKQTKFC-NIALCPGRAVDGNWNEWSSWSACSASCSQGRQQR 490
Query: 281 QRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEI 340
R CN P +GG C G T C CPVDG+W +W W C S++C
Sbjct: 491 TRECNG--PSYGGAECQGHWVETRDC-FLQQCPVDGKWQAWASWGSC------SVTCG-- 539
Query: 341 PGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCP 377
G Q R R C G F G C G Q + R C Q CP
Sbjct: 540 AGSQRRERVCSGPFFGGAACQGPQDEYRQC-GTQRCP 575
Score = 80.9 bits (198), Expect = 2e-15
Identities = 61/216 (28%), Positives = 81/216 (37%), Gaps = 39/216 (18%)
Query: 194 GAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPP 253
G W W W C+ C GG +TR+R C P+ G C G+ E R+C
Sbjct: 262 GGWKLWSLWGECTRDCGGG----LQTRTRTCL---PAPGVEGGGCEGVLEEGRQCN---- 310
Query: 254 CPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCP 313
GP G S + + + Q G P P
Sbjct: 311 ---REACGPAGRTSSRSQSLRSTDARRREELGDELQQFGFP---------------APQT 352
Query: 314 VDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSI 373
D + W WS C S +C E G Q+R R C + +C+G ++ R C +
Sbjct: 353 GDPAAEEWSPWSVC------SSTCGE--GWQTRTRFCVSSSYST-QCSGPLREQRLCNNS 403
Query: 374 QHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTP 409
CP+ G+W EWS W LC CG R R R C P
Sbjct: 404 AVCPVHGAWDEWSPWSLCSSTCG-RGFRDRTRTCRP 438
Score = 43.1 bits (100), Expect = 5e-04
Identities = 28/102 (27%), Positives = 43/102 (42%), Gaps = 11/102 (10%)
Query: 32 CFTQYEESSGKCKGLLGGGVSVEDCCLNTAFAYQKRSGGLCQPCR-SPRWSLWSTWAPCS 90
C ++ + +C G GG + + T + Q C +W W++W CS
Sbjct: 483 CSQGRQQRTRECNGPSYGGAECQGHWVETRDCF-------LQQCPVDGKWQAWASWGSCS 535
Query: 91 VTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQC 132
VTC GSQ R R C +G G A + + + C Q+C
Sbjct: 536 VTCGAGSQRRERVC---SGPFFGGAACQGPQDEYRQCGTQRC 574
>gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens]
Length = 1522
Score = 171 bits (432), Expect = 2e-42
Identities = 95/282 (33%), Positives = 122/282 (43%), Gaps = 35/282 (12%)
Query: 138 GWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWA 197
G W W CSVTC +G++ R R C P G HC G +ES C+ +CP HG W
Sbjct: 293 GVEEWSQWSTCSVTCGQGSQVRTRTCVSPY---GTHCSGPLRESRVCNNTALCPVHGVWE 349
Query: 198 TWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVA 257
W PW+ CS +C G + TR+R C+ P+ G+PC G + C + CPV
Sbjct: 350 EWSPWSLCSFTCGRG----QRTRTRSCTPPQYG----GRPCEGPETHHKPC-NIALCPVD 400
Query: 258 GGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGE 317
G W W S C VTC G R C HGG C G + C C +G+
Sbjct: 401 GQWQEWSSWSQCSVTCSNGTQQRSRQCT--AAAHGGSECRGPWAESRECYNP-ECTANGQ 457
Query: 318 WDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCP 377
W+ WG WS C S SC G + R RTC+G G +C G +++R C S Q CP
Sbjct: 458 WNQWGHWSGC------SKSCD--GGWERRIRTCQGAVITGQQCEGTGEEVRRC-SEQRCP 508
Query: 378 -----------LKGSWSEWSTWGLCMPPCGPNPTRARQRLCT 408
+ W L C N T R C+
Sbjct: 509 APYEICPEDYLMSMVWKRTPAGDLAFNQCPLNATGTTSRRCS 550
Score = 145 bits (366), Expect = 8e-35
Identities = 85/237 (35%), Positives = 105/237 (44%), Gaps = 23/237 (9%)
Query: 83 WSTWAPCSVTCSEGSQLRYRRCVGWNG-QCSGKVAPGTLEWQLQACEDQQCCPEMGGWSG 141
WS W+ CSVTC +GSQ+R R CV G CSG + + + C + CP G W
Sbjct: 297 WSQWSTCSVTCGQGSQVRTRTCVSPYGTHCSGPLR------ESRVCNNTALCPVHGVWEE 350
Query: 142 WGPWEPCSVTCSKGTRTRRRACNHPAPKCGGH-CPGQAQESEACDTQQVCPTHGAWATWG 200
W PW CS TC +G RTR R+C P+ GG C G + C+ +CP G W W
Sbjct: 351 WSPWSLCSFTCGRGQRTRTRSCT--PPQYGGRPCEGPETHHKPCNI-ALCPVDGQWQEWS 407
Query: 201 PWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGW 260
W+ CS +C G + RSR+C+A G C G E R C P C G W
Sbjct: 408 SWSQCSVTCSNGTQQ----RSRQCTAAAHG----GSECRGPWAESRECYN-PECTANGQW 458
Query: 261 GPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGE 317
WG S C +C G RTC V G C G C+ CP E
Sbjct: 459 NQWGHWSGCSKSCDGGWERRIRTCQGAVIT--GQQCEGTGEEVRRCSEQ-RCPAPYE 512
Score = 108 bits (271), Expect = 8e-24
Identities = 64/170 (37%), Positives = 76/170 (44%), Gaps = 14/170 (8%)
Query: 80 WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGW 139
W WS W+ CS TC G + R R C Q G+ G E + C + CP G W
Sbjct: 348 WEEWSPWSLCSFTCGRGQRTRTRSCT--PPQYGGRPCEGP-ETHHKPC-NIALCPVDGQW 403
Query: 140 SGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATW 199
W W CSVTCS GT+ R R C A G C G ES C + C +G W W
Sbjct: 404 QEWSSWSQCSVTCSNGTQQRSRQCT-AAAHGGSECRGPWAESRECYNPE-CTANGQWNQW 461
Query: 200 GPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCT 249
G W+ CS SC GG E R R C + G+ C G E RRC+
Sbjct: 462 GHWSGCSKSCDGG----WERRIRTCQGAVIT----GQQCEGTGEEVRRCS 503
Score = 78.2 bits (191), Expect = 2e-14
Identities = 50/158 (31%), Positives = 67/158 (42%), Gaps = 20/158 (12%)
Query: 79 RWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQC----CP 134
+W WS+W+ CSVTCS G+Q R R+C A G E + E ++C C
Sbjct: 402 QWQEWSSWSQCSVTCSNGTQQRSRQCTA--------AAHGGSECRGPWAESRECYNPECT 453
Query: 135 EMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQ------Q 188
G W+ WG W CS +C G R R C A G C G +E C Q +
Sbjct: 454 ANGQWNQWGHWSGCSKSCDGGWERRIRTC-QGAVITGQQCEGTGEEVRRCSEQRCPAPYE 512
Query: 189 VCPTHGAWATWGPWTPC-SASCHGGPHEPKETRSRKCS 225
+CP + TP + + P T SR+CS
Sbjct: 513 ICPEDYLMSMVWKRTPAGDLAFNQCPLNATGTTSRRCS 550
>gi|40317626 thrombospondin 1 precursor [Homo sapiens]
Length = 1170
Score = 156 bits (395), Expect = 3e-38
Identities = 88/256 (34%), Positives = 112/256 (43%), Gaps = 36/256 (14%)
Query: 129 DQQCCPEM-------GGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQES 181
D +CCP GWS W W CS +C G + R R+C+ C G + ++
Sbjct: 365 DGECCPRCWPSDSADDGWSPWSEWTSCSTSCGNGIQQRGRSCD----SLNNRCEGSSVQT 420
Query: 182 EACDTQQV---CPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPC 238
C Q+ G W+ W PW+ CS +C G TR R C++P P GKPC
Sbjct: 421 RTCHIQECDKRFKQDGGWSHWSPWSSCSVTCGDGVI----TRIRLCNSPSPQMN--GKPC 474
Query: 239 PGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAG 298
G A E + C CP+ GGWGPW P C VTCG G R CN+P PQ GG C G
Sbjct: 475 EGEARETKACKK-DACPINGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVG 533
Query: 299 DATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIP-GQQSRGRTCRGRKFDG 357
D T ICN CP+DG +PC + C P G G G +G
Sbjct: 534 DVTENQICNKQ-DCPIDGCLS-----NPC----FAGVKCTSYPDGSWKCGACPPGYSGNG 583
Query: 358 HRCAGQQQDIRHCYSI 373
+C D+ C +
Sbjct: 584 IQCT----DVDECKEV 595
Score = 143 bits (361), Expect = 3e-34
Identities = 74/183 (40%), Positives = 93/183 (50%), Gaps = 18/183 (9%)
Query: 80 WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQC---CPEM 136
WS WS W CS +C G Q R R C N +C G Q + C Q+C +
Sbjct: 382 WSPWSEWTSCSTSCGNGIQQRGRSCDSLNNRCEGSSV------QTRTCHIQECDKRFKQD 435
Query: 137 GGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGH-CPGQAQESEACDTQQVCPTHGA 195
GGWS W PW CSVTC G TR R CN P+P+ G C G+A+E++AC + CP +G
Sbjct: 436 GGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKAC-KKDACPINGG 494
Query: 196 WATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCP 255
W W PW CS +C GG + RSR C+ P P + GK C G E + C CP
Sbjct: 495 WGPWSPWDICSVTCGGG----VQKRSRLCNNPTP--QFGGKDCVGDVTENQIC-NKQDCP 547
Query: 256 VAG 258
+ G
Sbjct: 548 IDG 550
Score = 84.3 bits (207), Expect = 2e-16
Identities = 63/224 (28%), Positives = 91/224 (40%), Gaps = 39/224 (17%)
Query: 202 WTPCSAS-CHGGPHEPKETRSRKCSAP----EPSQKPPGKPCPGLAYEQRRCTGLPPCPV 256
WT S + CH + T +K S P + P G+ CP RC P
Sbjct: 331 WTVDSCTECHC---QNSVTICKKVSCPIMPCSNATVPDGECCP-------RCW--PSDSA 378
Query: 257 AGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPV-- 314
GW PW + C +CG G R+C+ + C G + +T C+ C
Sbjct: 379 DDGWSPWSEWTSCSTSCGNGIQQRGRSCDSLNNR-----CEGSSVQTRTCHIQ-ECDKRF 432
Query: 315 --DGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGR--KFDGHRCAGQQQDIRHC 370
DG W W WS C S++C + G +R R C + +G C G+ ++ + C
Sbjct: 433 KQDGGWSHWSPWSSC------SVTCGD--GVITRIRLCNSPSPQMNGKPCEGEARETKAC 484
Query: 371 YSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKY 414
CP+ G W WS W +C CG + R RLC P++
Sbjct: 485 KK-DACPINGGWGPWSPWDICSVTCG-GGVQKRSRLCNNPTPQF 526
>gi|115387099 brain-specific angiogenesis inhibitor 2 [Homo sapiens]
Length = 1585
Score = 152 bits (384), Expect = 6e-37
Identities = 94/311 (30%), Positives = 132/311 (42%), Gaps = 51/311 (16%)
Query: 142 WGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATWGP 201
W PW CS+TC +G + R R+C + G C G +E+ C+ CP HG W WG
Sbjct: 315 WSPWSVCSLTCGQGLQVRTRSC--VSSPYGTLCSGPLRETRPCNNSATCPVHGVWEEWGS 372
Query: 202 WTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWG 261
W+ CS SC G +R R C P+ GK C G + + C+ + CPV G W
Sbjct: 373 WSLCSRSCGRG----SRSRMRTCVPPQHG----GKACEGPELQTKLCS-MAACPVEGQWL 423
Query: 262 PWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCP-VDGEWDS 320
WGP PC +C G R C+ P C G T T C+ + CP D +W
Sbjct: 424 EWGPWGPCSTSCANGTQQRSRKCSVAGP--AWATCTGALTDTRECSN-LECPATDSKWGP 480
Query: 321 WGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCP--- 377
W WS C S +C G Q R R C+ G+ C G ++++ C S + CP
Sbjct: 481 WNAWSLC------SKTCD--TGWQRRFRMCQATGTQGYPCEGTGEEVKPC-SEKRCPAFH 531
Query: 378 --------LKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSMVEGQGEKNV 429
+ +W + + + C PN + + R C ++ QG V
Sbjct: 532 EMCRDEYVMLMTWKKAAAGEIIYNKCPPNASGSASRRC------------LLSAQG---V 576
Query: 430 TFWGRP-LPRC 439
+WG P RC
Sbjct: 577 AYWGLPSFARC 587
Score = 145 bits (366), Expect = 8e-35
Identities = 81/228 (35%), Positives = 103/228 (45%), Gaps = 22/228 (9%)
Query: 83 WSTWAPCSVTCSEGSQLRYRRCVG--WNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWS 140
WS W+ CS+TC +G Q+R R CV + CSG + + + C + CP G W
Sbjct: 315 WSPWSVCSLTCGQGLQVRTRSCVSSPYGTLCSGPLR------ETRPCNNSATCPVHGVWE 368
Query: 141 GWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATWG 200
WG W CS +C +G+R+R R C P G C G +++ C + CP G W WG
Sbjct: 369 EWGSWSLCSRSCGRGSRSRMRTC-VPPQHGGKACEGPELQTKLC-SMAACPVEGQWLEWG 426
Query: 201 PWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGG- 259
PW PCS SC G + RSRKCS P+ C G + R C+ L CP
Sbjct: 427 PWGPCSTSCANGTQQ----RSRKCSVAGPA----WATCTGALTDTRECSNL-ECPATDSK 477
Query: 260 WGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICN 307
WGPW S C TC G R C Q G C G C+
Sbjct: 478 WGPWNAWSLCSKTCDTGWQRRFRMCQATGTQ--GYPCEGTGEEVKPCS 523
Score = 107 bits (266), Expect = 3e-23
Identities = 58/170 (34%), Positives = 75/170 (44%), Gaps = 13/170 (7%)
Query: 80 WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGW 139
W W +W+ CS +C GS+ R R CV Q GK G E Q + C CP G W
Sbjct: 367 WEEWGSWSLCSRSCGRGSRSRMRTCVP--PQHGGKACEGP-ELQTKLCS-MAACPVEGQW 422
Query: 140 SGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATW 199
WGPW PCS +C+ GT+ R R C+ P C G ++ C + T W W
Sbjct: 423 LEWGPWGPCSTSCANGTQQRSRKCSVAGP-AWATCTGALTDTRECSNLECPATDSKWGPW 481
Query: 200 GPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCT 249
W+ CS +C G + R R C A G PC G E + C+
Sbjct: 482 NAWSLCSKTCDTG----WQRRFRMCQATGTQ----GYPCEGTGEEVKPCS 523
Score = 68.6 bits (166), Expect = 1e-11
Identities = 38/128 (29%), Positives = 55/128 (42%), Gaps = 16/128 (12%)
Query: 71 LCQPCRSP---RWSLWSTWAPCSVTCSEGSQLRYRRC----VGWNGQCSGKVAPGTLEWQ 123
LC P +W W W PCS +C+ G+Q R R+C W C+G +
Sbjct: 410 LCSMAACPVEGQWLEWGPWGPCSTSCANGTQQRSRKCSVAGPAW-ATCTGALT------D 462
Query: 124 LQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEA 183
+ C + +C W W W CS TC G + R R C + G C G +E +
Sbjct: 463 TRECSNLECPATDSKWGPWNAWSLCSKTCDTGWQRRFRMCQATGTQ-GYPCEGTGEEVKP 521
Query: 184 CDTQQVCP 191
C +++ CP
Sbjct: 522 C-SEKRCP 528
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 151 bits (381), Expect = 1e-36
Identities = 127/430 (29%), Positives = 171/430 (39%), Gaps = 89/430 (20%)
Query: 47 LGGGVSVEDCCLNTAFAYQKRSGGLCQPCRSPR-WSLWSTWAPCSVTCSE-GSQLRYRRC 104
L G ++ C N + A+ K S L + + WS W PCS +C G++ R R+C
Sbjct: 3780 LDSGQTLRTSCGNCSCAHGKLSCSLDDCFEADGGFGPWSPWGPCSRSCGGLGTRTRSRQC 3839
Query: 105 VGWNGQCSGKVAPGTLEWQLQACEDQQC----CPEM------------GGWSGWGPWEPC 148
V SG+ G + D +C CP GGW W W PC
Sbjct: 3840 VLTMPTLSGQGCRGPRQ-------DLECPSPDCPGAEGSTVEPVTGLPGGWGPWSSWSPC 3892
Query: 149 SVTCSKGTR----TRRRACNHPAPKCGGHCPGQAQESE--ACDTQQVCPTHG------AW 196
S +C+ R +R R C C P Q + +C VCP G +W
Sbjct: 3893 SRSCTDPARPAWRSRTRLC---LANCTMGDPLQERPCNLPSCTELPVCPGPGCGAGNCSW 3949
Query: 197 ATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGL--AYEQRRCTGLPPC 254
+W PW PCS SC G ++ R R P P G CP + AY++RR L C
Sbjct: 3950 TSWAPWEPCSRSCGVG----QQRRLRAYRPPGPG----GHWCPNILTAYQERRFCNLRAC 4001
Query: 255 PVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPV 314
PV GGW W P S C +CG GQ++ R+C+ P ++GG CAG+ + +CN P P
Sbjct: 4002 PVPGGWSRWSPWSWCDRSCGGGQSLRSRSCSSPPSKNGGAPCAGERHQARLCN---PMPC 4058
Query: 315 DGEWDSWGEWSPCIRR-------NMKSISCQEIPGQQSRGRTCRG--------------- 352
+ + E C R + I CQ+ Q R +G
Sbjct: 4059 EAGCPAGMEVVTCANRCPRRCSDLQEGIVCQDDQVCQKGCRCPKGSLEQDGGCVPIGHCD 4118
Query: 353 -RKFDGHRCA--GQQQDIRHCYSIQ----HC-------PLKGSWSEWSTWGLCMPPCGPN 398
GH A Q QD + S Q C P +WS WS W C CGP
Sbjct: 4119 CTDAQGHSWAPGSQHQDACNNCSCQAGQLSCTAQPCPPPTHCAWSHWSAWSPCSHSCGPR 4178
Query: 399 PTRARQRLCT 408
++R R T
Sbjct: 4179 GQQSRFRSST 4188
Score = 145 bits (367), Expect = 6e-35
Identities = 124/444 (27%), Positives = 169/444 (38%), Gaps = 70/444 (15%)
Query: 13 LPPLLLLLTLPATGSDPVLCF-TQYEESSGKCKGLLGGGVSVEDCCLNTAFAYQKRSGGL 71
+P ++ + LP + LC +Q SG+C +S E C
Sbjct: 2445 VPFMMPTMALPGLPASRALCSPSQLSCGSGEC-------LSAERRCDLRPDCQDGSDEDG 2497
Query: 72 CQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQ 131
C C WS+WS+ CS +C G L ++R G P ++ Q+C Q
Sbjct: 2498 CVDCVLAPWSVWSS---CSRSCGLG--LTFQRQELLRPPLPGGSCPRD-RFRSQSCF-VQ 2550
Query: 132 CCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGG-HCPGQAQESEACDTQQV- 189
CP G W+ W W PCSV+C G ++R+R+C P PK GG CPG +QE C Q
Sbjct: 2551 ACPVAGAWAMWEAWGPCSVSCGGGHQSRQRSCVDPPPKNGGAPCPGASQERAPCGLQPCS 2610
Query: 190 ----CPTHGAWAT-----WGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPG----- 235
C + + G PC SC +PK RS E + PPG
Sbjct: 2611 GGTDCELGRVYVSADLCQKGLVPPCPPSC----LDPKANRSCSGHCVEGCRCPPGLLLHD 2666
Query: 236 ------KPCPGLAYEQRRCTGLP---------------------PCPVAGGWGPWGPVSP 268
CP L E+ + G+ CP+ GW W +P
Sbjct: 2667 TRCLPLSECPCLVGEELKWPGVSFLLGNCSQCVCEKGELLCQPGGCPLPCGWSAWSSWAP 2726
Query: 269 CPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCI 328
C +CG G R+ ++P GG C GD C+T V G W W WS C
Sbjct: 2727 CDRSCGSGVRARFRSPSNPPAAWGGAPCEGDRQELQGCHTVCGTEVFG-WTPWTSWSSC- 2784
Query: 329 RRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTW 388
+ ++ PG +SR R C C G C S CP+ W W+ W
Sbjct: 2785 --SQSCLAPGGGPGWRSRSRLCPSP--GDSSCPGDATQEEPC-SPPVCPVPSIWGLWAPW 2839
Query: 389 GLCMPPCGPNPTRARQRLCTPLLP 412
C PC + R R C+ L P
Sbjct: 2840 STCSAPC-DGGIQTRGRSCSSLAP 2862
Score = 131 bits (329), Expect = 2e-30
Identities = 120/428 (28%), Positives = 152/428 (35%), Gaps = 108/428 (25%)
Query: 73 QPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQC 132
+PC P W W+PCSV C G + R R G + T Q A
Sbjct: 3037 RPCPGPGGE-WGPWSPCSVPCGGGYRNRTR------GSSRSLMEFSTCGLQPCAGPVPGM 3089
Query: 133 CPEMGGW--SGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCP-GQAQESEACDTQQV 189
CP W GP ++ +GT + C HP G HCP G + C Q
Sbjct: 3090 CPRDKQWLDCAQGPASCAELSAPRGTN---QTC-HP----GCHCPSGMLLLNNVCVPTQD 3141
Query: 190 CPT--------------------------------------HGAWATWGPWTPCSASCHG 211
CP W+ W PW+ CSASC
Sbjct: 3142 CPCAHEGHLYPPGSTVVRPCENCSCVSGLIANCSSWPCAEGEPTWSPWTPWSQCSASC-- 3199
Query: 212 GPHEPKETRSRKCS----------APEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWG 261
GP + R R C+ AP P P C G E+ C L C AGGWG
Sbjct: 3200 GP--ARCHRHRFCARSPSAVPSTVAPLPLPATPTPLCSGPEAEEEPCL-LQGCDRAGGWG 3256
Query: 262 PWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSW 321
PWGP S C +CG G R C+ P PQ G +C G + +C A+PCPV
Sbjct: 3257 PWGPWSHCSRSCGGGLRSRTRACDQPPPQGLGDYCEGPRAQGEVCQ-ALPCPVTNCTAIE 3315
Query: 322 G-EWSPCIRRNMKSI------------SCQEIPGQ--QSRGRTC------------RGRK 354
G E+SPC +S C PGQ S G C G++
Sbjct: 3316 GAEYSPCGPPCPRSCDDLVHCVWRCQPGCYCPPGQVLSSNGAICVQPGHCSCLDLLTGQR 3375
Query: 355 FDGHRCAGQQQDIRHCYSIQ--------HCPLKGSWSEWSTWGLCMPPCGPNPTRARQRL 406
+ HC ++ CP+ G W WS W +C PC TR+R R
Sbjct: 3376 HHPGARLARPDGCNHCTCLEGRLNCTDLPCPVPGGWCPWSEWTMCSQPC-RGQTRSRSRA 3434
Query: 407 CTPLLPKY 414
C P++
Sbjct: 3435 CACPTPQH 3442
Score = 129 bits (324), Expect = 6e-30
Identities = 122/413 (29%), Positives = 149/413 (36%), Gaps = 96/413 (23%)
Query: 57 CLNTAFAYQKRSGGLCQPCRSPR-WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKV 115
C N AYQ+R + C P WS WS W+ C +C G LR R C + G
Sbjct: 3983 CPNILTAYQERRFCNLRACPVPGGWSRWSPWSWCDRSCGGGQSLRSRSCSSPPSKNGGAP 4042
Query: 116 APGTLEWQLQACEDQQC----------------CPEMGGWSGWGPWEPCSVTCSKGTRTR 159
G Q + C C CP G C KG R
Sbjct: 4043 CAGERH-QARLCNPMPCEAGCPAGMEVVTCANRCPRRCSDLQEGIVCQDDQVCQKGCRCP 4101
Query: 160 RRACNHPAPKCG-GHC-----------PGQAQESEACD-----------TQQVCP--THG 194
+ + GHC PG +Q +AC+ T Q CP TH
Sbjct: 4102 KGSLEQDGGCVPIGHCDCTDAQGHSWAPG-SQHQDACNNCSCQAGQLSCTAQPCPPPTHC 4160
Query: 195 AWATWGPWTPCSASCHGGPHEPKETRSRKCS----APE------PSQKPPGKPCPGLAY- 243
AW+ W W+PCS SC GP +++R R + APE SQ P CP L
Sbjct: 4161 AWSHWSAWSPCSHSC--GPRG-QQSRFRSSTSGSWAPECREEQSQSQPCPQPSCPPLCLQ 4217
Query: 244 --------------EQRRCTGLPP--------CPVAGGWGPWGPVSPCPVTCGLGQTMEQ 281
E +RC+ P C V W W S CPV+CG G +
Sbjct: 4218 GTRSRTLGDSWLQGECQRCSCTPEGVICEDTECAVPEAWTLWSSWSDCPVSCGGGNQVRT 4277
Query: 282 RTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIP 341
R C P H P C G T+T PCP E SWG W PC R SC P
Sbjct: 4278 RACRAAAPHHRSPPCLGPDTQTR----QQPCPGLLEACSWGPWGPCSR------SCG--P 4325
Query: 342 GQQSRGRTC---RGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLC 391
G SR +C + D + CYS CP + WS WS+W C
Sbjct: 4326 GLASRSGSCPCLMAKADPTCNSTFLHLDTQGCYS-GPCPEECVWSSWSSWTRC 4377
Score = 123 bits (308), Expect = 4e-28
Identities = 119/450 (26%), Positives = 148/450 (32%), Gaps = 124/450 (27%)
Query: 71 LCQPC-RSPRWSLWSTWAPCSVTCSEGSQLRYRRC-----VGWNGQCSGKVAPGTLEWQL 124
L Q C R+ W W W+ CS +C G + R R C G C G A G + Q
Sbjct: 3245 LLQGCDRAGGWGPWGPWSHCSRSCGGGLRSRTRACDQPPPQGLGDYCEGPRAQGEV-CQA 3303
Query: 125 QACEDQQCCPEMGG-WSGWGPWEPCSVTCSKGTRTRRRA---CNHPAPKC---------- 170
C C G +S GP PC +C R C P +
Sbjct: 3304 LPCPVTNCTAIEGAEYSPCGP--PCPRSCDDLVHCVWRCQPGCYCPPGQVLSSNGAICVQ 3361
Query: 171 GGHC------------PG-QAQESEACD-----------TQQVCPTHGAWATWGPWTPCS 206
GHC PG + + C+ T CP G W W WT CS
Sbjct: 3362 PGHCSCLDLLTGQRHHPGARLARPDGCNHCTCLEGRLNCTDLPCPVPGGWCPWSEWTMCS 3421
Query: 207 ASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLA------YEQRRCTGLPPCPVAGGW 260
C G +RSR C+ P P G PC G A +++ C CPV G W
Sbjct: 3422 QPCRG----QTRSRSRACACPTPQHG--GAPCTGEAGEAGAQHQREACPSYATCPVDGAW 3475
Query: 261 GPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNT------------ 308
GPWGP SPC + LGQ+ R C+ P GG C G+ T++ C
Sbjct: 3476 GPWGPWSPCDMC--LGQSHRSRACSRPPTPEGGRPCPGNHTQSRPCQENSTQCTDCGGGQ 3533
Query: 309 -----AVPCPVDGEWDSWGEWSPCIRRNMKSISCQE------------------------ 339
PCP S + SP S+ CQ
Sbjct: 3534 SLHPCGQPCP-----RSCQDLSPGSVCQPGSVGCQPTCGCPLGQLSQDGLCVPPAHCRCQ 3588
Query: 340 -------IPGQQSRGRTCRGRKFD----GHRCAGQQQD------IRHCYSIQHCPLKGSW 382
IP QSR R ++ G G + I C + CP G W
Sbjct: 3589 YQPGAMGIPENQSRSAGSRFSSWESLEPGEVVTGPCDNCTCVAGILQCQEVPDCPDPGVW 3648
Query: 383 SEWSTWGLCMPPCGPNPTRARQRLCTPLLP 412
S W W C CG +R P P
Sbjct: 3649 SSWGPWEDCSVSCGGGEQLRSRRCARPPCP 3678
Score = 122 bits (305), Expect = 9e-28
Identities = 123/462 (26%), Positives = 160/462 (34%), Gaps = 110/462 (23%)
Query: 37 EESSGKCKGLLGGGVSVEDCCLNTAFAYQKRS-GGLCQP--------CRSPRWSLWSTW- 86
+E+S +C GGG S+ C + Q S G +CQP C P L
Sbjct: 3520 QENSTQCTDC-GGGQSLHPCGQPCPRSCQDLSPGSVCQPGSVGCQPTCGCPLGQLSQDGL 3578
Query: 87 ----APCSVTCSEG--------SQLRYRRCVGWNGQCSGKVAPG-----TLEWQLQACED 129
A C G S+ R W G+V G T + C++
Sbjct: 3579 CVPPAHCRCQYQPGAMGIPENQSRSAGSRFSSWESLEPGEVVTGPCDNCTCVAGILQCQE 3638
Query: 130 QQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQV 189
CP+ G WS WGPWE CSV+C G + R R C P CPG A++S C TQ
Sbjct: 3639 VPDCPDPGVWSSWGPWEDCSVSCGGGEQLRSRRCARPP------CPGPARQSRTCSTQVC 3692
Query: 190 ----CPTHGAWATWGPWTPC--------------SASCHGGPHEPKETRSRKCSAPE--- 228
CP + P C S C G H P+ T + + +
Sbjct: 3693 REAGCPAGRLYRECQPGEGCPFSCAHVTQQVGCFSEGCEEGCHCPEGTFQHRLACVQECP 3752
Query: 229 ------------PSQKPPGKPC-PG--LAYEQRRCTGLPPCPVA---------------G 258
+ PG+P PG L Q T C A G
Sbjct: 3753 CVLTAWLLQELGATIGDPGQPLGPGDELDSGQTLRTSCGNCSCAHGKLSCSLDDCFEADG 3812
Query: 259 GWGPWGPVSPCPVTC-GLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCP---- 313
G+GPW P PC +C GLG R C +P G C G R + + CP
Sbjct: 3813 GFGPWSPWGPCSRSCGGLGTRTRSRQCVLTMPTLSGQGCRG--PRQDLECPSPDCPGAEG 3870
Query: 314 --------VDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQ 365
+ G W W WSPC R S + P +SR R C G +
Sbjct: 3871 STVEPVTGLPGGWGPWSSWSPCSR----SCTDPARPAWRSRTRLCLANCTMGDPLQERPC 3926
Query: 366 DIRHCYSIQHCPLKG------SWSEWSTWGLCMPPCGPNPTR 401
++ C + CP G SW+ W+ W C CG R
Sbjct: 3927 NLPSCTELPVCPGPGCGAGNCSWTSWAPWEPCSRSCGVGQQR 3968
Score = 114 bits (286), Expect = 1e-25
Identities = 108/414 (26%), Positives = 140/414 (33%), Gaps = 94/414 (22%)
Query: 80 WSLWSTWAPCSVTCSEGSQLRYR--RCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMG 137
W+ W+ W PCS +C G Q R R R G G + +Q + + + CP G
Sbjct: 3949 WTSWAPWEPCSRSCGVGQQRRLRAYRPPGPGGHWCPNILTA---YQERRFCNLRACPVPG 4005
Query: 138 GWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGH-CPGQAQESEACDTQQV---CPTH 193
GWS W PW C +C G R R+C+ P K GG C G+ ++ C+ CP
Sbjct: 4006 GWSRWSPWSWCDRSCGGGQSLRSRSCSSPPSKNGGAPCAGERHQARLCNPMPCEAGCPAG 4065
Query: 194 GAWATWGPWTP--CSASCHGGPHEPKETRSRKCSAPEPSQKPPG---------------- 235
T P CS G + + + C P+ S + G
Sbjct: 4066 MEVVTCANRCPRRCSDLQEGIVCQDDQVCQKGCRCPKGSLEQDGGCVPIGHCDCTDAQGH 4125
Query: 236 KPCPGLAYE-----------QRRCTGLP-PCPVAGGWGPWGPVSPCPVTCG--------- 274
PG ++ Q CT P P P W W SPC +CG
Sbjct: 4126 SWAPGSQHQDACNNCSCQAGQLSCTAQPCPPPTHCAWSHWSAWSPCSHSCGPRGQQSRFR 4185
Query: 275 -------LGQTMEQRTCNHPVPQHGGPFCAGDATRTH---------------------IC 306
+ E+++ + P PQ P TR+ IC
Sbjct: 4186 SSTSGSWAPECREEQSQSQPCPQPSCPPLCLQGTRSRTLGDSWLQGECQRCSCTPEGVIC 4245
Query: 307 NTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHR---CAGQ 363
C V W W WS C +SC G Q R R CR HR C G
Sbjct: 4246 EDT-ECAVPEAWTLWSSWSDC------PVSCGG--GNQVRTRACRAAA-PHHRSPPCLGP 4295
Query: 364 QQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPT 417
R Q CP W WG C CGP +R C L+ K PT
Sbjct: 4296 DTQTRQ----QPCPGLLEACSWGPWGPCSRSCGPG-LASRSGSCPCLMAKADPT 4344
Score = 108 bits (271), Expect = 8e-24
Identities = 106/405 (26%), Positives = 137/405 (33%), Gaps = 93/405 (22%)
Query: 69 GGLCQP--CRSPR-WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQ 125
G +C+ C P W+LWS+W+ C V+C G+Q+R R C +P L Q
Sbjct: 4242 GVICEDTECAVPEAWTLWSSWSDCPVSCGGGNQVRTRAC---RAAAPHHRSPPCLGPDTQ 4298
Query: 126 ACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQ--ESEA 183
QQ CP + WGPW PCS +C G +R +C K C +++
Sbjct: 4299 T--RQQPCPGLLEACSWGPWGPCSRSCGPGLASRSGSCPCLMAKADPTCNSTFLHLDTQG 4356
Query: 184 CDTQQVCPTHGAWATWGPWTPCSASC-------HGGPHEPKETRSRKCS----------- 225
C + CP W++W WT CS H GP C+
Sbjct: 4357 CYSGP-CPEECVWSSWSSWTRCSCRVLVQQRYRHQGPASRGARAGAPCTRLDGHFRPCLI 4415
Query: 226 --APEPSQKPP------GKPCPGLA---YEQRRCTGLPPCPVAGGWGPWGPVSPC----- 269
E S PP G PC GL + C LPPC G + P G +
Sbjct: 4416 SNCSEDSCTPPFEFHACGSPCAGLCATHLSHQLCQDLPPCQ-PGCYCPKGLLEQAGGCIP 4474
Query: 270 PVTC--------GLGQTME-----QRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDG 316
P C G G T+ Q C + G C C +P
Sbjct: 4475 PEECNCWHTSAAGAGMTLAPGDRLQLGCKECECRRGELHCTSQG-----CQGLLPL---S 4526
Query: 317 EWDSWGEWSPCIR-----------------RNMKSISCQEIP---GQQSRGRTC----RG 352
EW W PC+ R+ +S P +Q R R C G
Sbjct: 4527 EWSEWSPCGPCLPPSALAPASRTALEEHWLRDPTGLSPTLAPLLASEQHRHRLCLDPATG 4586
Query: 353 RKFDG--HRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPC 395
R + G H C R C CP WS W W C PC
Sbjct: 4587 RPWTGAPHLCTAPLSQQRLCPDPGACPDSCQWSLWGPWSPCQVPC 4631
Score = 106 bits (264), Expect = 5e-23
Identities = 80/293 (27%), Positives = 104/293 (35%), Gaps = 60/293 (20%)
Query: 80 WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQC----CPE 135
W+ W++W+ CS +C L GW + +PG A +++ C CP
Sbjct: 2775 WTPWTSWSSCSQSC-----LAPGGGPGWRSRSRLCPSPGDSSCPGDATQEEPCSPPVCPV 2829
Query: 136 MGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQV---CPT 192
W W PW CS C G +TR R+C+ AP CPG ++ C+TQ CP
Sbjct: 2830 PSIWGLWAPWSTCSAPCDGGIQTRGRSCSSLAPG-DTTCPGPHSQTRDCNTQPCTAQCPE 2888
Query: 193 HGAWA-----------------TWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPG 235
+ + T GP C+ C G P S SQ
Sbjct: 2889 NMLFRSAEQCHQEGGPCPRLCLTQGPGIECTGFCAPGCTCPPGLFLHNASCLPRSQ---- 2944
Query: 236 KPCPGLAYEQRRCTGLPP---------------------CPVAGGWGPWGPVSPCPVTCG 274
CP + Q +G CPVA GW PW S C +C
Sbjct: 2945 --CPCQLHGQLYASGAMARLDSCNNCTCVSGKMACTSERCPVACGWSPWTLWSLCSCSCN 3002
Query: 275 LGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPC 327
+G R P GG C G C+ PCP G WG WSPC
Sbjct: 3003 VGIRRRFRAGTAPPAAFGGAECQGPTMEAEFCSLR-PCP--GPGGEWGPWSPC 3052
Score = 102 bits (253), Expect = 1e-21
Identities = 107/355 (30%), Positives = 132/355 (37%), Gaps = 77/355 (21%)
Query: 87 APCSVTCSEGSQLRYRRCVGWNGQCSG-KVAPGTLEWQLQACEDQQCCPEMGGWSGWGPW 145
AP C+ G CV C G + P + AC P +GG + G
Sbjct: 1604 APHHAPCARGPH-----CVSPEQLCDGVRQCPDGSDEGPDACGG---LPALGGPNRTGL- 1654
Query: 146 EPC-SVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTP 204
PC TC GT + P CG PGQ S +Q C GAW W PW P
Sbjct: 1655 -PCPEYTCPNGTCIGFQLVCDGQPDCGR--PGQVGPSPE---EQGC---GAWGPWSPWGP 1705
Query: 205 CSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWG 264
CS +C GP + RSR+CS P + CPG ++ + C CPV G W W
Sbjct: 1706 CSRTC--GPWG--QGRSRRCS---PLGLLVLQNCPGPEHQSQACF-TAACPVDGEWSTWS 1757
Query: 265 PVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSW--G 322
P S C C G QR C+ P Q+GG CA H PCP DG ++ G
Sbjct: 1758 PWSVCSEPCR-GTMTRQRQCHSP--QNGGRTCAALPGGLHSTRQTKPCPQDGCPNATCSG 1814
Query: 323 E--WSPCIRRNMKSISCQEIPGQQ----------------------SRG-----RTCR-- 351
E + PC ++C +I GQ S G R C
Sbjct: 1815 ELMFQPCAPC---PLTCDDISGQVTCPPDWPCGSPGCWCPEGQVLGSEGWCVWPRQCPCL 1871
Query: 352 ---GRKFDGHR-------CAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCG 396
R + G R C Q R C C + WS WS W C+ PCG
Sbjct: 1872 VDGARYWPGQRIKADCQLCICQDGRPRRCRLNPDCAVDCGWSSWSPWAKCLGPCG 1926
Score = 96.7 bits (239), Expect = 4e-20
Identities = 121/489 (24%), Positives = 153/489 (31%), Gaps = 160/489 (32%)
Query: 73 QPCRSPR------WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEW---- 122
+PC P W LW+ W+ CS C G Q R R C +APG
Sbjct: 2820 EPCSPPVCPVPSIWGLWAPWSTCSAPCDGGIQTRGRSC--------SSLAPGDTTCPGPH 2871
Query: 123 -QLQACEDQQC---CPEM------------GG-----WSGWGPWEPCS------VTCSKG 155
Q + C Q C CPE GG GP C+ TC G
Sbjct: 2872 SQTRDCNTQPCTAQCPENMLFRSAEQCHQEGGPCPRLCLTQGPGIECTGFCAPGCTCPPG 2931
Query: 156 TRTRRRACNHPAPKCGGHCPGQAQES------EACD-----------TQQVCPTHGAWAT 198
+C P +C GQ S ++C+ T + CP W+
Sbjct: 2932 LFLHNASCL-PRSQCPCQLHGQLYASGAMARLDSCNNCTCVSGKMACTSERCPVACGWSP 2990
Query: 199 WGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAG 258
W W+ CS SC+ G R R + P G C G E C+ L PCP G
Sbjct: 2991 WTLWSLCSCSCNVG------IRRRFRAGTAPPAAFGGAECQGPTMEAEFCS-LRPCPGPG 3043
Query: 259 G-WGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQH---GGPFCAGDATRTHICNTAVPCPV 314
G WGPW SPC V CG G R + + + G CAG PV
Sbjct: 3044 GEWGPW---SPCSVPCGGGYRNRTRGSSRSLMEFSTCGLQPCAG--------------PV 3086
Query: 315 DGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGR--------------------- 353
G +W C + SC E+ + +TC
Sbjct: 3087 PGMCPRDKQWLDCAQ---GPASCAELSAPRGTNQTCHPGCHCPSGMLLLNNVCVPTQDCP 3143
Query: 354 -KFDGH-------------RCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNP 399
+GH C+ I +C S + +WS W+ W C CGP
Sbjct: 3144 CAHEGHLYPPGSTVVRPCENCSCVSGLIANCSSWPCAEGEPTWSPWTPWSQCSASCGPAR 3203
Query: 400 TRARQRLCTPLLPKYPPTVSMVEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVP 459
R R C P TV+ PLP P P
Sbjct: 3204 CH-RHRFCARSPSAVPSTVA---------------PLP---------------LPATPTP 3232
Query: 460 ACKDPEEEE 468
C PE EE
Sbjct: 3233 LCSGPEAEE 3241
Score = 95.1 bits (235), Expect = 1e-19
Identities = 90/277 (32%), Positives = 111/277 (40%), Gaps = 53/277 (19%)
Query: 80 WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGW 139
W WS W PCS TC Q R RRC G + PG E Q QAC CP G W
Sbjct: 1697 WGPWSPWGPCSRTCGPWGQGRSRRCSPL-GLLVLQNCPGP-EHQSQAC-FTAACPVDGEW 1753
Query: 140 SGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGH----CPG---QAQESEACDTQQVCP- 191
S W PW CS C +GT TR+R C+ +P+ GG PG ++++ C Q CP
Sbjct: 1754 STWSPWSVCSEPC-RGTMTRQRQCH--SPQNGGRTCAALPGGLHSTRQTKPC-PQDGCPN 1809
Query: 192 -THGAWATWGPWTPCSASC---HGGPHEPKE--TRSRKCSAPE------------PSQKP 233
T + P PC +C G P + S C PE P Q P
Sbjct: 1810 ATCSGELMFQPCAPCPLTCDDISGQVTCPPDWPCGSPGCWCPEGQVLGSEGWCVWPRQCP 1869
Query: 234 ---------PGKP-------CPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQ 277
PG+ C RRC P C V GW W P + C CG Q
Sbjct: 1870 CLVDGARYWPGQRIKADCQLCICQDGRPRRCRLNPDCAVDCGWSSWSPWAKCLGPCG-SQ 1928
Query: 278 TMEQ--RTCNHPVPQHGGPFCAGDATRTHICNTAVPC 312
+++ R+ N+P P G C G + C T PC
Sbjct: 1929 SIQWSFRSSNNPRPSGRGRQCRGIHRKARRCQTE-PC 1964
Score = 82.0 bits (201), Expect = 1e-15
Identities = 84/297 (28%), Positives = 103/297 (34%), Gaps = 69/297 (23%)
Query: 72 CQPCRSP-------RWSLWSTW-------APCSVTCSEGSQLRYRRCVG------WNGQC 111
C PC P R +L W +P Q R+R C+ W G
Sbjct: 4534 CGPCLPPSALAPASRTALEEHWLRDPTGLSPTLAPLLASEQHRHRLCLDPATGRPWTGAP 4593
Query: 112 SGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRR--------AC 163
AP + Q + C D CP+ WS WGPW PC V CS G R R R C
Sbjct: 4594 HLCTAPLS---QQRLCPDPGACPDSCQWSLWGPWSPCQVPCSGGFRLRWREAEALCGGGC 4650
Query: 164 NHP--APKC-GGHCPG-QAQESE-ACDTQQVCPTHGAWATWGP----WTPCSASCHGGPH 214
P C GG CP +AQ++ D CP H W PC C P
Sbjct: 4651 REPWAQESCNGGPCPECEAQDTVFTLDCANQCP-HSCADLWDRVQCLQGPCRPGCRCPPG 4709
Query: 215 EPKE------TRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGL--------PPCPVAGGW 260
+ + S +C P + P + + + CT + CPV G W
Sbjct: 4710 QLVQDGRCVPISSCRCGLPSANASWELAPAQAVQLDCQNCTCVNESLVCPHQECPVLGPW 4769
Query: 261 GPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFC----AGDATRTHICNTAVPCP 313
W S C CG G RTC GGP A D + CN PCP
Sbjct: 4770 SAW---SSCSAPCGGGTMERHRTC------EGGPGVAPCQAQDTEQRQECNLQ-PCP 4816
Score = 80.9 bits (198), Expect = 2e-15
Identities = 96/341 (28%), Positives = 116/341 (34%), Gaps = 67/341 (19%)
Query: 89 CSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWG----- 143
C E S L CV C GT +Q C+ CP+ G G G
Sbjct: 1477 CLDAADEESCLGQVTCVPGEVSC----VDGTCLGAIQLCDGVWDCPD-GADEGPGHCPLP 1531
Query: 144 --PWEPCSVTC-----SKGTRTRRRACNHPAPKCG--------GHCPGQAQESEACDTQQ 188
P P S S T + A PAP CG G C + CD ++
Sbjct: 1532 SLPTPPASTLPGPSPGSLDTASSPLASASPAPPCGPFEFRCGSGECTPRGWR---CDQEE 1588
Query: 189 VCPTHG-AWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPG-KPCPGLAYE-Q 245
C GP P A C GPH C +PE Q G + CP + E
Sbjct: 1589 DCADGSDERGCGGPCAPHHAPCARGPH---------CVSPE--QLCDGVRQCPDGSDEGP 1637
Query: 246 RRCTGLPPCPVAGGWGPWGPVSPCP-VTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTH 304
C GLP GP PCP TC G + + P G P G +
Sbjct: 1638 DACGGLPALG-----GPNRTGLPCPEYTCPNGTCIGFQLVCDGQPDCGRPGQVGPSPEEQ 1692
Query: 305 ICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDG-HRCAGQ 363
C G W W W PC R +C P Q R R C C G
Sbjct: 1693 GC---------GAWGPWSPWGPCSR------TCG--PWGQGRSRRCSPLGLLVLQNCPGP 1735
Query: 364 QQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQ 404
+ + C++ CP+ G WS WS W +C PC TR RQ
Sbjct: 1736 EHQSQACFTAA-CPVDGEWSTWSPWSVCSEPCRGTMTRQRQ 1775
Score = 72.4 bits (176), Expect = 8e-13
Identities = 125/516 (24%), Positives = 167/516 (32%), Gaps = 144/516 (27%)
Query: 40 SGKCKGLLGGGVSVEDCCLNTAFAYQKRSGGLCQPCRSPR-WSLWSTWAPCSVTCSEGSQ 98
SG C L+ D N+ F + G PC WS WS+W CS C Q
Sbjct: 4331 SGSCPCLMAKA----DPTCNSTFLHLDTQGCYSGPCPEECVWSSWSSWTRCS--CRVLVQ 4384
Query: 99 LRYRRCVGWNGQCSGKVAPGT-LEWQLQACEDQQCCPEMGGWSGWGPWE------PCSVT 151
RYR G + + AP T L+ + C C + S P+E PC+
Sbjct: 4385 QRYRH-QGPASRGARAGAPCTRLDGHFRPCLISNCSED----SCTPPFEFHACGSPCAGL 4439
Query: 152 CSKGTRTRRRACNHPAP-KCGGHCP-GQAQESEAC-----------------------DT 186
C+ T + C P + G +CP G +++ C D
Sbjct: 4440 CA--THLSHQLCQDLPPCQPGCYCPKGLLEQAGGCIPPEECNCWHTSAAGAGMTLAPGDR 4497
Query: 187 QQV-------------CPTHGA--------WATWGPWTPCSASCHGGP-----------H 214
Q+ C + G W+ W P PC P
Sbjct: 4498 LQLGCKECECRRGELHCTSQGCQGLLPLSEWSEWSPCGPCLPPSALAPASRTALEEHWLR 4557
Query: 215 EP-------------KETRSRKCSAPEPSQKPPGKP--CPGLAYEQRRCTGLPPCPVAGG 259
+P ++ R R C P + G P C +QR C CP +
Sbjct: 4558 DPTGLSPTLAPLLASEQHRHRLCLDPATGRPWTGAPHLCTAPLSQQRLCPDPGACPDSCQ 4617
Query: 260 WGPWGPVSPCPVTCGLGQTMEQRT--------CNHPVPQ---HGGPF--C-AGDATRTHI 305
W WGP SPC V C G + R C P Q +GGP C A D T
Sbjct: 4618 WSLWGPWSPCQVPCSGGFRLRWREAEALCGGGCREPWAQESCNGGPCPECEAQDTVFTLD 4677
Query: 306 CNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCA---- 361
C P WD C++ + C+ PGQ + C RC
Sbjct: 4678 CANQCPHSCADLWDR----VQCLQGPCRP-GCRCPPGQLVQDGRCV--PISSCRCGLPSA 4730
Query: 362 ----------GQQQDIRHCYSI--------QHCPLKGSWSEWSTWGLCMPPCGPNPTRAR 403
Q D ++C + Q CP+ G WS WS+ C PCG T R
Sbjct: 4731 NASWELAPAQAVQLDCQNCTCVNESLVCPHQECPVLGPWSAWSS---CSAPCG-GGTMER 4786
Query: 404 QRLCTPLLPKYPPTVSMVEGQGEKNVTFWGRPLPRC 439
R C P E + E N+ +P P C
Sbjct: 4787 HRTCEGGPGVAPCQAQDTEQRQECNL----QPCPEC 4818
Score = 46.2 bits (108), Expect = 6e-05
Identities = 65/261 (24%), Positives = 83/261 (31%), Gaps = 40/261 (15%)
Query: 71 LCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNG--QCSGKVAPGTLEWQLQACE 128
+C P WS W+ CS C G+ R+R C G G C + E LQ C
Sbjct: 4757 VCPHQECPVLGPWSAWSSCSAPCGGGTMERHRTCEGGPGVAPCQAQDTEQRQECNLQPCP 4816
Query: 129 DQQCCPEMGGWSGWGPWEPCSV-TCSKGTRTRRRACNHPAPKCGGHCP-GQAQESEACDT 186
+ CP S PC G + C P CG CP GQ + C
Sbjct: 4817 E---CPPGQVLSACATSCPCLCWHLQPGAICVQEPCQ---PGCG--CPGGQLLHNGTCVP 4868
Query: 187 QQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQR 246
CP WG P P +R C+ C G A+
Sbjct: 4869 PTACPCTQHSLPWGLTLTLEEQAQELP--PGTVLTRNCTR---------CVCHGGAFS-- 4915
Query: 247 RCTGLPPCPVAGGWGPWGPVSP-----CPVTC-GLGQTMEQRTCNHPVPQHGGPFCAGDA 300
L C V G W V+P C TC + T Q C+ + G C
Sbjct: 4916 --CSLVDCQVPPG-ETWQQVAPGELGLCEQTCLEMNATKTQSNCSS--ARASGCVCQPG- 4969
Query: 301 TRTHICNTAVPCPVDGEWDSW 321
H + A PC + + W
Sbjct: 4970 ---HFRSQAGPCVPEDHCECW 4987
Score = 41.6 bits (96), Expect = 0.002
Identities = 39/140 (27%), Positives = 55/140 (39%), Gaps = 19/140 (13%)
Query: 238 CPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCA 297
CP L+ RRC P PW + CPV C GQ E R C QH G
Sbjct: 798 CPVLSAYARRCAQEGASP------PWRNQTLCPVMCPGGQ--EYRECAPACGQHCGK--P 847
Query: 298 GDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDG 357
D C CP+ WD G+ P + + + PG + + C
Sbjct: 848 EDCGELGSCVAGCNCPLGLLWDPEGQCVPPSLCPCQLGARRYAPGSATM-KEC------- 899
Query: 358 HRCAGQQQDIRHCYSIQHCP 377
+RC Q++ + +C + +HCP
Sbjct: 900 NRCICQERGLWNC-TARHCP 918
Score = 33.9 bits (76), Expect = 0.33
Identities = 42/164 (25%), Positives = 53/164 (32%), Gaps = 21/164 (12%)
Query: 163 CNHPAPKC--GGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETR 220
C + A C GG C + S C HG W CS C GG + E
Sbjct: 1229 CLYDACGCDSGGDC--ECLCSAIATYADECARHGHHVRWRSQELCSLQCEGG--QVYEAC 1284
Query: 221 SRKCSAPEPSQKP-PGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQ-- 277
C Q P PG C +A C CP + P C G+
Sbjct: 1285 GPTCPPTCHEQHPEPGWHCQVVA-----CVEGCFCPEGTLLHGGACLEPASCPCEWGRNS 1339
Query: 278 ----TMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGE 317
++ Q+ C + Q G C GD C VP +GE
Sbjct: 1340 FPPGSVLQKDCGNCTCQEGQWHCGGDGGH---CEELVPACAEGE 1380
Score = 32.3 bits (72), Expect = 0.95
Identities = 60/230 (26%), Positives = 71/230 (30%), Gaps = 42/230 (18%)
Query: 190 CPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKP--CPGLAYEQRR 247
C GA W T C C GG R+C AP Q GKP C L
Sbjct: 808 CAQEGASPPWRNQTLCPVMCPGG------QEYREC-APACGQH-CGKPEDCGELG----S 855
Query: 248 CTGLPPCPVAGGWGPWG---PVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTH 304
C CP+ W P G P S CP C LG + G AT
Sbjct: 856 CVAGCNCPLGLLWDPEGQCVPPSLCP--CQLGARR---------------YAPGSATMKE 898
Query: 305 ICNTAVPCPVDGEWDSWGEWSP----CIRRNMKSI-SCQEIPGQQSRGRTCRGRKFDGHR 359
CN + C G W+ P C R + + +C S +C DG
Sbjct: 899 -CNRCI-CQERGLWNCTARHCPSQAFCPRELVYAPGACLLTCDSPSANHSCPAGSTDGCV 956
Query: 360 C-AGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCT 408
C G C CP + S + C R RQ CT
Sbjct: 957 CPPGTVLLDERCVPPDLCPCRHSGQWYLPNATIQEDCNVCVCRGRQWHCT 1006
Score = 30.0 bits (66), Expect = 4.7
Identities = 37/139 (26%), Positives = 43/139 (30%), Gaps = 37/139 (26%)
Query: 83 WSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLE-------WQLQ--ACEDQQCC 133
W + CS+ C EG Q+ Y C G P T W Q AC + C
Sbjct: 1265 WRSQELCSLQC-EGGQV-YEAC--------GPTCPPTCHEQHPEPGWHCQVVACVEGCFC 1314
Query: 134 PEMGGWSGWGPWEPCSVTCSKGTRT-----------RRRACNHPAPKC---GGHC----P 175
PE G EP S C G + C C GGHC P
Sbjct: 1315 PEGTLLHGGACLEPASCPCEWGRNSFPPGSVLQKDCGNCTCQEGQWHCGGDGGHCEELVP 1374
Query: 176 GQAQESEACDTQQVCPTHG 194
A+ C C HG
Sbjct: 1375 ACAEGEALCQENGHCVPHG 1393
>gi|40317628 thrombospondin 2 precursor [Homo sapiens]
Length = 1172
Score = 149 bits (376), Expect = 5e-36
Identities = 78/194 (40%), Positives = 94/194 (48%), Gaps = 18/194 (9%)
Query: 131 QCCPEM-------GGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKC-GGHCPGQAQESE 182
+CCP GWS W W CSVTC GT+ R R+C+ + C G +A
Sbjct: 369 ECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLS 428
Query: 183 ACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLA 242
CDT+ G W+ W PW+ CS +C G TR R C++P P GK C G
Sbjct: 429 KCDTR--IRQDGGWSHWSPWSSCSVTCGVG----NITRIRLCNSPVPQMG--GKNCKGSG 480
Query: 243 YEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATR 302
E + C G P CP+ G W PW P S C VTC G R CN P PQ+GG C GD
Sbjct: 481 RETKACQGAP-CPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQE 539
Query: 303 THICNTAVPCPVDG 316
+CN CPVDG
Sbjct: 540 RQMCNKR-SCPVDG 552
Score = 144 bits (363), Expect = 2e-34
Identities = 75/183 (40%), Positives = 95/183 (51%), Gaps = 18/183 (9%)
Query: 80 WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEM--- 136
WS W+ W CSVTC G+Q R R C + C G Q +AC +C +
Sbjct: 384 WSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGP------SIQTRACSLSKCDTRIRQD 437
Query: 137 GGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGG-HCPGQAQESEACDTQQVCPTHGA 195
GGWS W PW CSVTC G TR R CN P P+ GG +C G +E++AC CP G
Sbjct: 438 GGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAP-CPIDGR 496
Query: 196 WATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCP 255
W+ W PW+ C+ +C GG E R+R C++PEP GK C G E++ C CP
Sbjct: 497 WSPWSPWSACTVTCAGGIRE----RTRVCNSPEPQY--GGKACVGDVQERQMC-NKRSCP 549
Query: 256 VAG 258
V G
Sbjct: 550 VDG 552
Score = 120 bits (301), Expect = 3e-27
Identities = 72/223 (32%), Positives = 95/223 (42%), Gaps = 35/223 (15%)
Query: 174 CPGQAQESEACDTQQVCPT-------HGAWATWGPWTPCSASCHGGPHEPKETRSRKCSA 226
CP S + + CP+ W+ W WT CS +C G + R R C
Sbjct: 355 CPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQ----RGRSCDV 410
Query: 227 PEPSQKPPGKPCPGLAYEQRRCTGLPPCPVA----GGWGPWGPVSPCPVTCGLGQTMEQR 282
+ C G + + R C+ L C GGW W P S C VTCG+G R
Sbjct: 411 TSNT-------CLGPSIQTRACS-LSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIR 462
Query: 283 TCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPG 342
CN PVPQ GG C G T C A PCP+DG W W WS C +++C G
Sbjct: 463 LCNSPVPQMGGKNCKGSGRETKACQGA-PCPIDGRWSPWSPWSAC------TVTC--AGG 513
Query: 343 QQSRGRTCRG--RKFDGHRCAGQQQDIRHCYSIQHCPLKGSWS 383
+ R R C ++ G C G Q+ + C + + CP+ G S
Sbjct: 514 IRERTRVCNSPEPQYGGKACVGDVQERQMC-NKRSCPVDGCLS 555
Score = 84.7 bits (208), Expect = 2e-16
Identities = 57/187 (30%), Positives = 75/187 (40%), Gaps = 20/187 (10%)
Query: 234 PGKPCPGLAYEQRRCTGLPPC--PVAG--GWGPWGPVSPCPVTCGLGQTMEQRTCNHPVP 289
P C ++ + C P C V G GW PW + C VTCG G R+C+
Sbjct: 356 PPATCASPSFVEGECC--PSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSN 413
Query: 290 QHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRT 349
GP A C+T + DG W W WS C S++C G +R R
Sbjct: 414 TCLGPSIQTRACSLSKCDTRIR--QDGGWSHWSPWSSC------SVTCGV--GNITRIRL 463
Query: 350 CRGR--KFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLC 407
C + G C G ++ + C CP+ G WS WS W C C R R R+C
Sbjct: 464 CNSPVPQMGGKNCKGSGRETKACQGAP-CPIDGRWSPWSPWSACTVTCA-GGIRERTRVC 521
Query: 408 TPLLPKY 414
P+Y
Sbjct: 522 NSPEPQY 528
Score = 46.2 bits (108), Expect = 6e-05
Identities = 24/64 (37%), Positives = 32/64 (50%), Gaps = 4/64 (6%)
Query: 72 CQPCRSP---RWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACE 128
CQ P RWS WS W+ C+VTC+ G + R R C Q GK G ++ + Q C
Sbjct: 486 CQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQ-ERQMCN 544
Query: 129 DQQC 132
+ C
Sbjct: 545 KRSC 548
>gi|32261318 unc-5 homolog B [Homo sapiens]
Length = 945
Score = 103 bits (256), Expect = 4e-22
Identities = 48/114 (42%), Positives = 58/114 (50%), Gaps = 12/114 (10%)
Query: 137 GGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGG-HCPGQAQESEACDTQQVCPTHGA 195
GGWS W W PCS C +G + R R C +PAP GG C GQA + AC T +CP GA
Sbjct: 247 GGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTT--ICPVDGA 304
Query: 196 WATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCT 249
W W W+ CS C RSR+C AP P G+ C G + + CT
Sbjct: 305 WTEWSKWSACSTEC-------AHWRSRECMAPPPQN--GGRDCSGTLLDSKNCT 349
Score = 91.3 bits (225), Expect = 2e-18
Identities = 44/107 (41%), Positives = 51/107 (47%), Gaps = 5/107 (4%)
Query: 256 VAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVD 315
V GGW W SPC CG G RTC +P P +GG FC G A + C T CPVD
Sbjct: 245 VNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTI--CPVD 302
Query: 316 GEWDSWGEWSPCIRR--NMKSISCQEIPGQQSRGRTCRGRKFDGHRC 360
G W W +WS C + +S C P Q+ GR C G D C
Sbjct: 303 GAWTEWSKWSACSTECAHWRSRECM-APPPQNGGRDCSGTLLDSKNC 348
Score = 74.3 bits (181), Expect = 2e-13
Identities = 39/114 (34%), Positives = 53/114 (46%), Gaps = 11/114 (9%)
Query: 193 HGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLP 252
+G W++W W+PCS C G + R+R C+ P P G C G A+++ CT +
Sbjct: 246 NGGWSSWAEWSPCSNRCGRG----WQKRTRTCTNPAPLN--GGAFCEGQAFQKTACTTI- 298
Query: 253 PCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHIC 306
CPV G W W S C C R C P PQ+GG C+G + C
Sbjct: 299 -CPVDGAWTEWSKWSACSTECA---HWRSRECMAPPPQNGGRDCSGTLLDSKNC 348
Score = 68.9 bits (167), Expect = 9e-12
Identities = 40/112 (35%), Positives = 49/112 (43%), Gaps = 8/112 (7%)
Query: 80 WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGW 139
WS W+ W+PCS C G Q R R C G G +Q AC CP G W
Sbjct: 249 WSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQ-AFQKTAC--TTICPVDGAW 305
Query: 140 SGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGH-CPGQAQESEACDTQQVC 190
+ W W CS C+ R R C P P+ GG C G +S+ C T +C
Sbjct: 306 TEWSKWSACSTECA---HWRSRECMAPPPQNGGRDCSGTLLDSKNC-TDGLC 353
Score = 62.4 bits (150), Expect = 9e-10
Identities = 36/98 (36%), Positives = 45/98 (45%), Gaps = 14/98 (14%)
Query: 314 VDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRK--FDGHRCAGQQQDIRHCY 371
V+G W SW EWSPC R + G Q R RTC G C GQ C
Sbjct: 245 VNGGWSSWAEWSPCSNRCGR--------GWQKRTRTCTNPAPLNGGAFCEGQAFQKTACT 296
Query: 372 SIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTP 409
+I CP+ G+W+EWS W C C R+R+ + P
Sbjct: 297 TI--CPVDGAWTEWSKWSACSTECA--HWRSRECMAPP 330
>gi|110347423 spondin 1, extracellular matrix protein [Homo sapiens]
Length = 807
Score = 102 bits (255), Expect = 6e-22
Identities = 78/255 (30%), Positives = 105/255 (41%), Gaps = 26/255 (10%)
Query: 80 WSLWSTWAPC-SVTCSEGSQLRYRRCVGWNGQCSGKV-APGTLEWQLQACEDQQCCPEMG 137
+S WS W+ C S TC +G ++R R Q V P T ++ Q C C E G
Sbjct: 445 YSNWSPWSACSSSTCDKGKRMRQRML---KAQLDLSVPCPDTQDF--QPCMGPGCSDEDG 499
Query: 138 G---WSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVC-PTH 193
S W W PCS++C G R+R R P+ G C +E+E C + C P+
Sbjct: 500 STCTMSEWITWSPCSISCGMGMRSRERYVKQ-FPEDGSVCTLPTEETEKCTVNEECSPSS 558
Query: 194 GAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPP 253
WG W CSA+C G K R K + + G C + +C +P
Sbjct: 559 CLMTEWGEWDECSATC--GMGMKKRHRMIKMNPAD------GSMCKAETSQAEKCM-MPE 609
Query: 254 C-PVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPC 312
C + PW S C VTCG G QR + + G C D + C C
Sbjct: 610 CHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLK-SLAELGD--CNEDLEQVEKC-MLPEC 665
Query: 313 PVDGEWDSWGEWSPC 327
P+D E W +WS C
Sbjct: 666 PIDCELTEWSQWSEC 680
Score = 88.2 bits (217), Expect = 1e-17
Identities = 75/278 (26%), Positives = 106/278 (38%), Gaps = 35/278 (12%)
Query: 128 EDQQCCPEMGGWSGWGPWEPCSV-TCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDT 186
+D+ PE +S W PW CS TC KG R R+R CP Q+ + C
Sbjct: 434 KDEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLD-LSVPCP-DTQDFQPCMG 491
Query: 187 QQVCPTHGAWAT---WGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAY 243
G+ T W W+PCS SC G RSR+ + + G C
Sbjct: 492 PGCSDEDGSTCTMSEWITWSPCSISCGMG------MRSRERYVKQFPED--GSVCTLPTE 543
Query: 244 EQRRCTGLPPC-PVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATR 302
E +CT C P + WG C TCG+G R + G C + ++
Sbjct: 544 ETEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIK--MNPADGSMCKAETSQ 601
Query: 303 THICNT----AVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGH 358
C +PC + W EWS C S++C + G ++R R + G
Sbjct: 602 AEKCMMPECHTIPCLLS----PWSEWSDC------SVTCGK--GMRTRQRMLKSLAELGD 649
Query: 359 RCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCG 396
C + + C + CP+ +EWS W C CG
Sbjct: 650 -CNEDLEQVEKCM-LPECPIDCELTEWSQWSECNKSCG 685
Score = 85.1 bits (209), Expect = 1e-16
Identities = 62/234 (26%), Positives = 87/234 (37%), Gaps = 24/234 (10%)
Query: 73 QPCRSP----------RWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEW 122
QPC P S W TW+PCS++C G + R R + G V E
Sbjct: 487 QPCMGPGCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPED--GSVCTLPTEE 544
Query: 123 QLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESE 182
+ +++C P + WG W+ CS TC G + R R P G C + ++E
Sbjct: 545 TEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIK-MNPADGSMCKAETSQAE 603
Query: 183 ACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLA 242
C + + W W+ CS +C G TR R + C
Sbjct: 604 KCMMPECHTIPCLLSPWSEWSDCSVTCGKG----MRTRQRMLKSLAEL-----GDCNEDL 654
Query: 243 YEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFC 296
+ +C LP CP+ W S C +CG G + R PQ GG C
Sbjct: 655 EQVEKCM-LPECPIDCELTEWSQWSECNKSCGKGHVIRTRMIQME-PQFGGAPC 706
Score = 67.8 bits (164), Expect = 2e-11
Identities = 59/220 (26%), Positives = 77/220 (35%), Gaps = 36/220 (16%)
Query: 83 WSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGW 142
W W CS TC G + R+R G + Q + C +C S W
Sbjct: 564 WGEWDECSATCGMGMKKRHRMIK--MNPADGSMCKAETS-QAEKCMMPECHTIPCLLSPW 620
Query: 143 GPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPW 202
W CSVTC KG RTR+R A G C ++ E C + CP W W
Sbjct: 621 SEWSDCSVTCGKGMRTRQRMLKSLAEL--GDCNEDLEQVEKCMLPE-CPIDCELTEWSQW 677
Query: 203 TPCSASC----------------HGGPHEPKETRSRKCSAPEPSQKPPGKPCPGL-AYEQ 245
+ C+ SC GG P+ + +KC + + P + A E
Sbjct: 678 SECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQRKKCRIRKCLRNPSIQKLRWREARES 737
Query: 246 RRCTGL---------PPCPVAGGWGPWGPVSPCPVTCGLG 276
RR L P C + PW S C CG G
Sbjct: 738 RRSEQLKEESEGEQFPGCRMR----PWTAWSECTKLCGGG 773
>gi|16933525 unc5C [Homo sapiens]
Length = 931
Score = 95.1 bits (235), Expect = 1e-19
Identities = 45/114 (39%), Positives = 57/114 (50%), Gaps = 12/114 (10%)
Query: 137 GGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGG-HCPGQAQESEACDTQQVCPTHGA 195
GGWS W W C+ C +G + R R C +PAP GG C GQ+ + AC T +CP G
Sbjct: 261 GGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTT--LCPVDGR 318
Query: 196 WATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCT 249
W W W+ C C R R+C+AP P K GK C GL + + CT
Sbjct: 319 WTPWSKWSTCGTEC-------THWRRRECTAPAP--KNGGKDCDGLVLQSKNCT 363
Score = 78.6 bits (192), Expect = 1e-14
Identities = 38/107 (35%), Positives = 48/107 (44%), Gaps = 5/107 (4%)
Query: 256 VAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVD 315
V GGW W S C CG G RTC +P P +GG FC G + + C T CPVD
Sbjct: 259 VNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTL--CPVD 316
Query: 316 GEWDSWGEWSPCIRR--NMKSISCQEIPGQQSRGRTCRGRKFDGHRC 360
G W W +WS C + + C P ++ G+ C G C
Sbjct: 317 GRWTPWSKWSTCGTECTHWRRREC-TAPAPKNGGKDCDGLVLQSKNC 362
Score = 70.9 bits (172), Expect = 2e-12
Identities = 38/114 (33%), Positives = 54/114 (47%), Gaps = 11/114 (9%)
Query: 193 HGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLP 252
+G W+TW W+ C++ C G + R+R C+ P P G C G + ++ CT L
Sbjct: 260 NGGWSTWTEWSVCNSRCGRG----YQKRTRTCTNPAPLN--GGAFCEGQSVQKIACTTL- 312
Query: 253 PCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHIC 306
CPV G W PW S C C +R C P P++GG C G ++ C
Sbjct: 313 -CPVDGRWTPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDGLVLQSKNC 362
Score = 69.3 bits (168), Expect = 7e-12
Identities = 39/112 (34%), Positives = 47/112 (41%), Gaps = 8/112 (7%)
Query: 80 WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGW 139
WS W+ W+ C+ C G Q R R C G G +Q CP G W
Sbjct: 263 WSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQ---SVQKIACTTLCPVDGRW 319
Query: 140 SGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGG-HCPGQAQESEACDTQQVC 190
+ W W C C T RRR C PAPK GG C G +S+ C T +C
Sbjct: 320 TPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDGLVLQSKNC-TDGLC 367
Score = 57.8 bits (138), Expect = 2e-08
Identities = 36/102 (35%), Positives = 44/102 (43%), Gaps = 16/102 (15%)
Query: 314 VDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRK--FDGHRCAGQQQDIRHCY 371
V+G W +W EWS C R + G Q R RTC G C GQ C
Sbjct: 259 VNGGWSTWTEWSVCNSRCGR--------GYQKRTRTCTNPAPLNGGAFCEGQSVQKIACT 310
Query: 372 SIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPK 413
++ CP+ G W+ WS W C C T R+R CT PK
Sbjct: 311 TL--CPVDGRWTPWSKWSTCGTEC----THWRRRECTAPAPK 346
Score = 31.6 bits (70), Expect = 1.6
Identities = 18/54 (33%), Positives = 23/54 (42%), Gaps = 4/54 (7%)
Query: 79 RWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQC 132
RW+ WS W+ C C + R R C + GK G L Q + C D C
Sbjct: 318 RWTPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDG-LVLQSKNCTDGLC 367
>gi|209977117 unc-5 homolog D [Homo sapiens]
Length = 953
Score = 94.4 bits (233), Expect = 2e-19
Identities = 44/114 (38%), Positives = 59/114 (51%), Gaps = 12/114 (10%)
Query: 137 GGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGG-HCPGQAQESEACDTQQVCPTHGA 195
GGWS W W C+V C +G + R R C +PAP GG C G + + C + +CP G+
Sbjct: 253 GGWSSWTEWSACNVRCGRGWQKRSRTCTNPAPLNGGAFCEGMSVQKITCTS--LCPVDGS 310
Query: 196 WATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCT 249
W W W+ CS C + R R+C+AP P + GK C GL+ E CT
Sbjct: 311 WEVWSEWSVCSPEC-------EHLRIRECTAPPP--RNGGKFCEGLSQESENCT 355
Score = 82.4 bits (202), Expect = 8e-16
Identities = 40/112 (35%), Positives = 52/112 (46%), Gaps = 15/112 (13%)
Query: 256 VAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVD 315
V GGW W S C V CG G RTC +P P +GG FC G + + C + CPVD
Sbjct: 251 VNGGWSSWTEWSACNVRCGRGWQKRSRTCTNPAPLNGGAFCEGMSVQKITCTSL--CPVD 308
Query: 316 GEWDSWGEWSPCIRRNMKSISCQEI-------PGQQSRGRTCRGRKFDGHRC 360
G W+ W EWS C S C+ + P ++ G+ C G + C
Sbjct: 309 GSWEVWSEWSVC------SPECEHLRIRECTAPPPRNGGKFCEGLSQESENC 354
Score = 73.6 bits (179), Expect = 4e-13
Identities = 40/123 (32%), Positives = 59/123 (47%), Gaps = 12/123 (9%)
Query: 193 HGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLP 252
+G W++W W+ C+ C G + RSR C+ P P G C G++ ++ CT L
Sbjct: 252 NGGWSSWTEWSACNVRCGRG----WQKRSRTCTNPAPLN--GGAFCEGMSVQKITCTSL- 304
Query: 253 PCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPC 312
CPV G W W S C C + + R C P P++GG FC G + + C + C
Sbjct: 305 -CPVDGSWEVWSEWSVCSPEC---EHLRIRECTAPPPRNGGKFCEGLSQESENCTDGL-C 359
Query: 313 PVD 315
+D
Sbjct: 360 ILD 362
Score = 70.1 bits (170), Expect = 4e-12
Identities = 40/112 (35%), Positives = 47/112 (41%), Gaps = 8/112 (7%)
Query: 80 WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGW 139
WS W+ W+ C+V C G Q R R C G G +Q CP G W
Sbjct: 255 WSSWTEWSACNVRCGRGWQKRSRTCTNPAPLNGGAFCEG---MSVQKITCTSLCPVDGSW 311
Query: 140 SGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGG-HCPGQAQESEACDTQQVC 190
W W CS C R R C P P+ GG C G +QESE C T +C
Sbjct: 312 EVWSEWSVCSPECE---HLRIRECTAPPPRNGGKFCEGLSQESENC-TDGLC 359
Score = 60.5 bits (145), Expect = 3e-09
Identities = 37/102 (36%), Positives = 44/102 (43%), Gaps = 16/102 (15%)
Query: 314 VDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRK--FDGHRCAGQQQDIRHCY 371
V+G W SW EWS C ++ C G Q R RTC G C G C
Sbjct: 251 VNGGWSSWTEWSAC------NVRCGR--GWQKRSRTCTNPAPLNGGAFCEGMSVQKITCT 302
Query: 372 SIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPK 413
S+ CP+ GSW WS W +C P C R R CT P+
Sbjct: 303 SL--CPVDGSWEVWSEWSVCSPEC----EHLRIRECTAPPPR 338
>gi|150170672 thrombospondin, type I, domain containing 7A [Homo
sapiens]
Length = 1657
Score = 92.4 bits (228), Expect = 8e-19
Identities = 101/371 (27%), Positives = 138/371 (37%), Gaps = 78/371 (21%)
Query: 74 PCRSP-RWSLWST--WAPCSVT-------CSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQ 123
PC S LW T W+ C VT C EG Q R RC+ T +
Sbjct: 1089 PCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCM-----------QNTADGP 1137
Query: 124 LQACEDQQC---------------CPEMGGWSGWGPWEPCSVTCSKGTRTRRRA--CNHP 166
+ ED C CPE S WGPW C + C++ + +R A P
Sbjct: 1138 SEHVEDYLCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQP 1197
Query: 167 APKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSA 226
A + G CP A E E C+ + C + T W+ C S +TR C
Sbjct: 1198 ADE-GRSCP-NAVEKEPCNLNKNCYHYDYNVT--DWSTCQLSEKAVCGNGIKTRMLDCVR 1253
Query: 227 PEPSQKPPGKPCPGLAYE---QRRCTGLPPCPVAGGWGPWGPVSPCPVTCGL-GQTMEQR 282
+ + K C L E Q + + CPV W P S C TCGL G+ + +R
Sbjct: 1254 SD-GKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRR 1312
Query: 283 TCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDG--EWDSWGEWSPCIRRNMKSISCQEI 340
T P G P C + + + PCPV W +G+WSPC ++ C E
Sbjct: 1313 TVTQPFQGDGRP-CPS------LMDQSKPCPVKPCYRW-QYGQWSPC---QVQEAQCGE- 1360
Query: 341 PGQQSRGRTC---------RGRKFDGHRCA-------GQQQDIRHCYSIQHCPLKGSWSE 384
G ++R +C + D CA G + + Q CP +
Sbjct: 1361 -GTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQPCPGDCYLKD 1419
Query: 385 WSTWGLCMPPC 395
WS+W LC C
Sbjct: 1420 WSSWSLCQLTC 1430
Score = 78.6 bits (192), Expect = 1e-14
Identities = 89/368 (24%), Positives = 129/368 (35%), Gaps = 80/368 (21%)
Query: 81 SLWSTWAPCSVTCS----EGSQLRYRRCVGWNGQCSGKVAPGTLEWQ-LQACEDQQCCPE 135
S WSTW+ CS TCS EG Q+R R + + G+ G P + Q +++C + C
Sbjct: 638 STWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCT-- 695
Query: 136 MGGWSGWGPWEPC-----------------SVTCSKGTRTRRRAC-----NHPAPKCGGH 173
+ W GPW C +CS G +TR+ C PK
Sbjct: 696 VYHWQT-GPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPK---K 751
Query: 174 CPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKP 233
CP + C + WT C +SC G ++ + P+
Sbjct: 752 CPESLRPETVRPCLLPCKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANG- 810
Query: 234 PGKPCPGLAYEQRRCTGLPPCPV----AGGWG-----PWGPVSPCPVT---CGLGQTMEQ 281
G+ C YE++ C C W PW P CG G+
Sbjct: 811 -GRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARA 869
Query: 282 RTCN---------HPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNM 332
TC H Q+ GP A T C +PC D + SW ++S C
Sbjct: 870 ITCRKQDGGQAGIHECLQYAGPVPA----LTQACQ--IPCQDDCQLTSWSKFSSC----- 918
Query: 333 KSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSI---QHCPL-KGSWSEWSTW 388
+ C + ++R RT G+ +C H Y + Q+CP K + W
Sbjct: 919 -NGDCGAV---RTRKRTLVGKSKKKEKCKNS-----HLYPLIETQYCPCDKYNAQPVGNW 969
Query: 389 GLCMPPCG 396
C+ P G
Sbjct: 970 SDCILPEG 977
Score = 68.2 bits (165), Expect = 2e-11
Identities = 92/359 (25%), Positives = 129/359 (35%), Gaps = 68/359 (18%)
Query: 93 CSEGSQLRYRRCVGWNGQ------CSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWE 146
C G+Q++ C+ +G+ C + P + AC+ CP+ S W W
Sbjct: 592 CGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPV-----ACDAP--CPKDCVLSTWSTWS 644
Query: 147 PCSVTCS----KGTRTRRRACNHPAPKCGG-HCPGQA--QESEACDTQQVCPTHGAWATW 199
CS TCS +G + R R+ A + GG CP + QE +C+ H W T
Sbjct: 645 SCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVYH--WQT- 701
Query: 200 GPWTPC-----------------SASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLA 242
GPW C ASC G +TR C Q P K CP
Sbjct: 702 GPWGQCIEDTSVSSFNTTTTWNGEASCSVG----MQTRKVICVRVNVGQVGP-KKCPESL 756
Query: 243 YEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPV----PQHGGPFCAG 298
+ L PC P+ + CP +C G + ++ H V P +GG C
Sbjct: 757 RPETVRPCLLPCKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTD 816
Query: 299 DATRTHICNTAVPCPVDGEWDSWGEWSPC------IRRNMKSISCQEIPGQQSRGRTCRG 352
C C W + +W C ++++ PG+Q+R TCR
Sbjct: 817 PLYEEKACEAPQACQ-SYRWKTH-KWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCR- 873
Query: 353 RKFDG-----HRC---AGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRAR 403
K DG H C AG + I C + WS + C CG TR R
Sbjct: 874 -KQDGGQAGIHECLQYAGPVPALTQACQIP-CQDDCQLTSWSKFSSCNGDCGAVRTRKR 930
Score = 68.2 bits (165), Expect = 2e-11
Identities = 80/346 (23%), Positives = 119/346 (34%), Gaps = 54/346 (15%)
Query: 93 CSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTC 152
C +G + + C NG+ + + +AC CP S W W CS +C
Sbjct: 994 CGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIP--CPSDCKLSEWSNWSRCSKSC 1051
Query: 153 SKGTRTRRRACNHPAPKCGGHCP-----GQAQESEACDTQQVCPTHGAWATWGPWTPCS- 206
G + R + G CP QAQ E C + W T PW+ C
Sbjct: 1052 GSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQY-LWVT-EPWSICKV 1109
Query: 207 --ASCHGGPHEPKETRSRKC---SAPEPSQKPPGKPC--PGLAYEQRRCTGLPPCP---V 256
+ E +TR +C +A PS+ C + R C PCP V
Sbjct: 1110 TFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCK--LPCPEDCV 1167
Query: 257 AGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDG 316
WGPW + C + C ++ P G C +A CN C
Sbjct: 1168 ISEWGPW---TQCVLPCNQSSFRQRSADPIRQPADEGRSCP-NAVEKEPCNLNKNC---Y 1220
Query: 317 EWD-SWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSI-- 373
+D + +WS C ++ + G + R D R G+ D+++C ++
Sbjct: 1221 HYDYNVTDWSTC-----------QLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGL 1269
Query: 374 -----------QHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCT 408
CP+ S+WS W C CG R+R T
Sbjct: 1270 EKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVT 1315
Score = 57.8 bits (138), Expect = 2e-08
Identities = 84/329 (25%), Positives = 113/329 (34%), Gaps = 47/329 (14%)
Query: 81 SLWSTWAPCSV-TCSE-----GSQLRYRRCVGWNGQCSGKVAPGTLEWQLQA--CEDQQC 132
S WS W PC+ C++ G +LR RR N G G L+A CE+ C
Sbjct: 516 SPWSAWGPCTYENCNDQQGKKGFKLRKRRIT--NEPTGGSGVTGNCPHLLEAIPCEEPAC 573
Query: 133 CPEMGGWSG--WGPWEPCS-VTCSKGTRTRRRAC-NHPAPKCGGHCPGQA--QESEACDT 186
W G EP + C GT+ + C N + A ACD
Sbjct: 574 YD----WKAVRLGNCEPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDA 629
Query: 187 QQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQR 246
CP +TW W+ CS +C G E K+ R+R A + P E R
Sbjct: 630 P--CPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVR 687
Query: 247 RCTGLPPCPVAGGWGPWG------PVSPCPVT--------CGLGQTMEQRTC-NHPVPQH 291
C P GPWG VS T C +G + C V Q
Sbjct: 688 SCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQV 747
Query: 292 GGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPG---QQSRGR 348
G C + +PC D + +W+ C SC+E +QSR R
Sbjct: 748 GPKKCPESLRPETVRPCLLPCKKDCIVTPYSDWTSC------PSSCKEGDSSIRKQSRHR 801
Query: 349 TCRGRKFDGHR-CAGQQQDIRHCYSIQHC 376
+G R C + + C + Q C
Sbjct: 802 VIIQLPANGGRDCTDPLYEEKACEAPQAC 830
Score = 55.1 bits (131), Expect = 1e-07
Identities = 94/369 (25%), Positives = 121/369 (32%), Gaps = 91/369 (24%)
Query: 96 GSQLRYRRCVGWNGQ------CSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCS 149
G Q R C+ G+ C + P T Q+C + C S W W PCS
Sbjct: 322 GYQTREVMCINKTGKAADLSFCQQEKLPMTF----QSCVITKECQV----SEWSEWSPCS 373
Query: 150 VTCSK-----GTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQ----VCPTHGAWATWG 200
TC GTR R R CP + +E E C +Q C T+G W T
Sbjct: 374 KTCHDMVSPAGTRVRTRTIRQFPIGSEKECP-EFEEKEPCLSQGDGVVPCATYG-WRTT- 430
Query: 201 PWTPC----------------SASCHGGPHEPKETRSRKCSAPEPS---------QKPPG 235
WT C +A C GG +TR C + K
Sbjct: 431 EWTECRVDPLLSQQDKRRGNQTALCGGGI----QTREVYCVQANENLLSQLSTHKNKEAS 486
Query: 236 KPCPGLAYEQRRCTG-LP--------PCPVAGGWGPWGPVSPCPV-TCGLGQ------TM 279
KP + + CTG +P PCP PW PC C Q
Sbjct: 487 KPM-----DLKLCTGPIPNTTQLCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLR 541
Query: 280 EQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQE 339
++R N P GG G+ H+ A+PC +D W N + + +E
Sbjct: 542 KRRITNEPT---GGSGVTGNCP--HLLE-AIPCEEPACYD----WKAVRLGNCEPDNGKE 591
Query: 340 I-PGQQSRGRTC---RGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPC 395
PG Q + C G + D C I CP S WSTW C C
Sbjct: 592 CGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAP-CPKDCVLSTWSTWSSCSHTC 650
Query: 396 GPNPTRARQ 404
T +Q
Sbjct: 651 SGKTTEGKQ 659
Score = 51.2 bits (121), Expect = 2e-06
Identities = 40/150 (26%), Positives = 55/150 (36%), Gaps = 28/150 (18%)
Query: 83 WSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGW 142
WS W+ CS TC ++ RR V Q G+ P ++ Q + C + C W +
Sbjct: 1292 WSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSLMD-QSKPCPVKPCYR----WQ-Y 1345
Query: 143 GPWEPCSVT---CSKGTRTRRRACNHPAPKCGGHCPGQAQE-----------------SE 182
G W PC V C +GTRTR +C +E E
Sbjct: 1346 GQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEE 1405
Query: 183 ACDTQQVCPTHGAWATWGPWTPCSASCHGG 212
+C Q CP W W+ C +C G
Sbjct: 1406 SCS--QPCPGDCYLKDWSSWSLCQLTCVNG 1433
Score = 46.2 bits (108), Expect = 6e-05
Identities = 89/387 (22%), Positives = 122/387 (31%), Gaps = 117/387 (30%)
Query: 81 SLWSTWAPCSVTCSE-----GSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPE 135
S WS W+PCS TC + G+++R R + P E + E+++ C
Sbjct: 364 SEWSEWSPCSKTCHDMVSPAGTRVRTRTI---------RQFPIGSEKECPEFEEKEPCLS 414
Query: 136 MG------GWSGW--GPWEPCSV----------------TCSKGTRTRRRAC-------- 163
G GW W C V C G +TR C
Sbjct: 415 QGDGVVPCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLL 474
Query: 164 -------NHPAPK------CGGHCPGQAQESEACDTQQVCPTH---GAWATWGPWTPCSA 207
N A K C G P Q C CPT W+ WGP T +
Sbjct: 475 SQLSTHKNKEASKPMDLKLCTGPIPNTTQ---LCHIP--CPTECEVSPWSAWGPCTYENC 529
Query: 208 SCHGGPHEPKETRSRKCSAPEPSQKPPGK--------PCPGLAYEQRRCTGLPPCPVAGG 259
+ G K + R + P G PC A + L C G
Sbjct: 530 NDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNG 589
Query: 260 --WGPWGPVSPCPVTCGLGQTMEQRTCN---HPVPQHGGPFCAGDATRTHICNTAVPCPV 314
GP V G+ ++++ C P+P A DA PCP
Sbjct: 590 KECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIP------VACDA----------PCPK 633
Query: 315 DGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKF-------DGHRCAGQQ--Q 365
D +W WS C S +C G+ + G+ R R G RC Q
Sbjct: 634 DCVLSTWSTWSSC------SHTCS---GKTTEGKQIRARSILAYAGEEGGIRCPNSSALQ 684
Query: 366 DIRHCYSIQHCPLKGSWSEWSTWGLCM 392
++R C +H W + WG C+
Sbjct: 685 EVRSCN--EHPCTVYHW-QTGPWGQCI 708
Score = 44.3 bits (103), Expect = 2e-04
Identities = 30/82 (36%), Positives = 38/82 (46%), Gaps = 4/82 (4%)
Query: 81 SLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWS 140
S +S W+ CS TC G Q R R V Q G P E+Q+ C+ C E +S
Sbjct: 198 SEFSAWSECSKTCGSGLQHRTRHVVA-PPQFGGSGCPNLTEFQV--CQSSPCEAEELRYS 254
Query: 141 -GWGPWEPCSVTCSKGTRTRRR 161
GPW CS+ S+ R RR
Sbjct: 255 LHVGPWSTCSMPHSRQVRQARR 276
Score = 37.7 bits (86), Expect = 0.023
Identities = 26/101 (25%), Positives = 41/101 (40%), Gaps = 13/101 (12%)
Query: 140 SGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPG----QAQESEACDTQQVCPTHGA 195
S + W CS TC G + R R P G CP Q +S C+ +++ +
Sbjct: 198 SEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSSPCEAEELRYSLHV 257
Query: 196 WATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGK 236
GPW+ CS PH + ++R+ + +K K
Sbjct: 258 ----GPWSTCSM-----PHSRQVRQARRRGKNKEREKDRSK 289
Score = 32.0 bits (71), Expect = 1.2
Identities = 33/135 (24%), Positives = 47/135 (34%), Gaps = 26/135 (19%)
Query: 73 QPCRSPRWSLWSTWAPCSV---TCSEGSQLRYRRCVGWNGQCS--GKVAPGTLEWQLQAC 127
+PC ++ WS PC V C EG++ R CV +G KV ++
Sbjct: 1338 KPCYRWQYGQWS---PCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELI 1394
Query: 128 ED-----------QQCCPEMGGWSGWGPWEPCSVTCSK-------GTRTRRRACNHPAPK 169
D Q CP W W C +TC G + R R +
Sbjct: 1395 IDGNKNMVLEESCSQPCPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELE 1454
Query: 170 CGGHCPGQAQESEAC 184
CP Q E+++C
Sbjct: 1455 NQHLCPEQMLETKSC 1469
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 85.9 bits (211), Expect = 7e-17
Identities = 97/336 (28%), Positives = 132/336 (39%), Gaps = 60/336 (17%)
Query: 83 WST--WAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWS 140
W T W CS TC+ GSQ R C NG + + +ACE CP+ W+
Sbjct: 1332 WRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGP-CPQ---WA 1387
Query: 141 GWGPWEPCSVTCSKGTRTRRRACNHP----APKCGGHCPGQAQESEACDTQQVCPTHGAW 196
+G W C+ C G RTR C P + + E C+T CP AW
Sbjct: 1388 -YGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNT-HACPHDAAW 1445
Query: 197 ATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLA--YEQRRCTGLPPC 254
+T GPW+ CS SC G + R+ C A + S C LA + R+C G C
Sbjct: 1446 ST-GPWSSCSVSCGRG----HKQRNVYCMAKDGSHL-ESDYCKHLAKPHGHRKCRG-GRC 1498
Query: 255 P--VAGGWGPWGPVSPCPVTCGLGQTMEQRTC---NHPVPQHG--GPFCAGDATRTHICN 307
P AG W S C V+CG G C H + + P+ ++ R C
Sbjct: 1499 PKWKAGAW------SQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERD--CQ 1550
Query: 308 TAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTC---RGRKFDGHRCAGQQ 364
CP+ W + EW C + +C E G + R C + G RC +
Sbjct: 1551 -GPRCPL-YTWRA-EEWQECTK------TCGE--GSRYRKVVCVDDNKNEVHGARCDVSK 1599
Query: 365 QDI-RHCYSIQHCP---LKGSWSEWSTWGLCMPPCG 396
+ + R S+Q C + G WSE C CG
Sbjct: 1600 RPVDRESCSLQPCEYVWITGEWSE------CSVTCG 1629
Score = 85.5 bits (210), Expect = 9e-17
Identities = 102/388 (26%), Positives = 133/388 (34%), Gaps = 94/388 (24%)
Query: 73 QPCRSPRWSLWST--WAPCSVTCSEGSQLRYRRC-------VGWNGQCSGKVAP-GTLEW 122
Q C+ P + W W CSVTC +G QLR +C V + C+ P T +
Sbjct: 1101 QTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDC 1160
Query: 123 QLQACEDQQCCPE---------MGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGH 173
+L +C PE W +G W PCS TC KGTR R +C
Sbjct: 1161 ELPSCHPPPAAPETRRSTYSAPRTQWR-FGSWTPCSATCGKGTRMRYVSCRDE------- 1212
Query: 174 CPGQAQESEACDT------QQVCPTH--GAWATWGPWTPCSASCHGG------------P 213
G + AC T ++ C G W W+ CS +C G
Sbjct: 1213 -NGSVADESACATLPRPVAKEECSVTPCGQWKAL-DWSSCSVTCGQGRATRQVMCVNYSD 1270
Query: 214 HEPKETRSRKCSAPEPSQKPPGKPCP------GLAY-----EQRRCTGLPP--CPVAGG- 259
H + + PE Q PCP GLA E R P V GG
Sbjct: 1271 HVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGN 1330
Query: 260 -W--GPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDAT------RTHICNTAV 310
W GPWG C TC G C Q + A D C +
Sbjct: 1331 QWRTGPWG---ACSSTCAGGSQRRVVVC-----QDENGYTANDCVERIKPDEQRACESG- 1381
Query: 311 PCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRC--AGQQQDIR 368
PCP +W ++G W C + I + + Q+S G +F C + D
Sbjct: 1382 PCP---QW-AYGNWGECTKLCGGGIRTRLVVCQRS-----NGERFPDLSCEILDKPPDRE 1432
Query: 369 HCYSIQHCPLKGSWSEWSTWGLCMPPCG 396
C + CP +WS W C CG
Sbjct: 1433 QC-NTHACPHDAAWST-GPWSSCSVSCG 1458
Score = 68.6 bits (166), Expect = 1e-11
Identities = 92/393 (23%), Positives = 128/393 (32%), Gaps = 109/393 (27%)
Query: 72 CQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQ 131
C+ P+W+ + W C+ C G + R C NG+ ++ L+ + + +Q
Sbjct: 1378 CESGPCPQWA-YGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILD---KPPDREQ 1433
Query: 132 C----CPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQ 187
C CP WS GPW CSV+C +G + R C K G H ES+ C +
Sbjct: 1434 CNTHACPHDAAWST-GPWSSCSVSCGRGHKQRNVYC---MAKDGSHL-----ESDYC--K 1482
Query: 188 QVCPTHG----------AWATWGPWTPCSASCHGGPHE------------PKETRSRKCS 225
+ HG W G W+ CS SC G + +ET +
Sbjct: 1483 HLAKPHGHRKCRGGRCPKWKA-GAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYT 1541
Query: 226 APEPSQKPPGKPCP---GLAYEQRRCT--------------------------------- 249
PE + G CP A E + CT
Sbjct: 1542 RPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRP 1601
Query: 250 ------GLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTC--------NHPVPQHGGPF 295
L PC G W S C VTCG G +C N+
Sbjct: 1602 VDRESCSLQPCEYVWITGEW---SECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTIN 1658
Query: 296 CAG-DATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTC-RGR 353
C G H C CPV W G W C S+SC G R C
Sbjct: 1659 CPGTQPPSVHPCYLR-DCPVSATW-RVGNWGSC------SVSCG--VGVMQRSVQCLTNE 1708
Query: 354 KFDGHRCAG--QQQDIRHCYSIQHCPLKGSWSE 384
H C + ++ + C ++ +C L + E
Sbjct: 1709 DQPSHLCHTDLKPEERKTCRNVYNCELPQNCKE 1741
Score = 67.0 bits (162), Expect = 3e-11
Identities = 78/300 (26%), Positives = 111/300 (37%), Gaps = 54/300 (18%)
Query: 75 CRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGW-NGQCSGKVAPGTLEWQLQACEDQQCC 133
C + W +S W CS +C G+Q R CV N + +Q C + C
Sbjct: 996 CNTGGWR-YSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVTIQRCSEFPC- 1053
Query: 134 PEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGH-CPGQAQESEACDTQQVCPT 192
P+ W G W C VTC KG + R+ C + C + + + QQ P
Sbjct: 1054 PQ---WKS-GDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQ--PE 1107
Query: 193 HGAWATWGPWTPCSASCHGGPHEPKETRSRKC---------------SAPEPSQ----KP 233
+W GPW CS +C G + R+ KC +A P+ +
Sbjct: 1108 CASWQA-GPWGQCSVTCGQG----YQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCEL 1162
Query: 234 PGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTC---NHPVPQ 290
P P A E RR T P +G W +PC TCG G M +C N V
Sbjct: 1163 PSCHPPPAAPETRRSTYSAP-RTQWRFGSW---TPCSATCGKGTRMRYVSCRDENGSVAD 1218
Query: 291 HGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTC 350
C + PC G+W + +WS C S++C + G+ +R C
Sbjct: 1219 ESACATLPRPVAKEEC-SVTPC---GQWKAL-DWSSC------SVTCGQ--GRATRQVMC 1265
Score = 56.2 bits (134), Expect = 6e-08
Identities = 24/55 (43%), Positives = 28/55 (50%), Gaps = 1/55 (1%)
Query: 258 GGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPC 312
G WG W P C TCG G R CN P P++GG +C G + CNT PC
Sbjct: 589 GSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTE-PC 642
Score = 55.5 bits (132), Expect = 1e-07
Identities = 37/116 (31%), Positives = 50/116 (43%), Gaps = 14/116 (12%)
Query: 86 WAPCSVTCSEGSQLRYRRCVGWNGQCSG------KVAPGTLEWQLQACEDQQCCPEM--- 136
+ P S C Q R C NG G A GT + C+ C P+
Sbjct: 525 FGPGSQVCPYMMQCRRLWCNNVNGVHKGCRTQHTPWADGTECEPGKHCKYGFCVPKEMDV 584
Query: 137 ----GGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGG-HCPGQAQESEACDTQ 187
G W W P+ CS TC G +T R CN P PK GG +C G+ + ++C+T+
Sbjct: 585 PVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTE 640
Score = 45.8 bits (107), Expect = 8e-05
Identities = 34/102 (33%), Positives = 48/102 (47%), Gaps = 14/102 (13%)
Query: 154 KGTRTRRRACNHPAPKCGGHC-PGQAQESEACDTQQ--VCPTHGAWATWGPWTPCSASCH 210
KG RT+ H G C PG+ + C ++ V T G+W +W P+ CS +C
Sbjct: 551 KGCRTQ-----HTPWADGTECEPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCG 605
Query: 211 GGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLP 252
GG +T R+C+ PEP K GK C G + + C P
Sbjct: 606 GG----IKTAIRECNRPEP--KNGGKYCVGRRMKFKSCNTEP 641
Score = 44.7 bits (104), Expect = 2e-04
Identities = 66/285 (23%), Positives = 88/285 (30%), Gaps = 94/285 (32%)
Query: 134 PEMGGWSGWGPWEPCSVTCSKGTRTRRRAC--------------------NHPAPKCGGH 173
P+ W+ GPW+ CS C +G R R+ C H CG
Sbjct: 876 PQQFYWNSHGPWQACSKPC-QGERKRKLVCTRESDQLTVSDQRCDRLPQPGHITEPCGTD 934
Query: 174 C------PGQAQESEAC-------------------DTQQV----CPTH----------- 193
C +++ S C T++V C +H
Sbjct: 935 CDLRWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSG 994
Query: 194 ----GAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCT 249
G W + WT CS SC GG + R C K +RC+
Sbjct: 995 ECNTGGW-RYSAWTECSKSCDGG----TQRRRAICVNTRNDVLDDSKCTHQEKVTIQRCS 1049
Query: 250 GLPPCP--VAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICN 307
PCP +G W S C VTCG G Q C + C + T +
Sbjct: 1050 EF-PCPQWKSGDW------SECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQT 1102
Query: 308 TAVPCPVDGEWDSW--GEWSPCIRRNMKSISCQEIPGQQSRGRTC 350
P E SW G W C S++C + G Q R C
Sbjct: 1103 CQQP-----ECASWQAGPWGQC------SVTCGQ--GYQLRAVKC 1134
Score = 41.6 bits (96), Expect = 0.002
Identities = 75/299 (25%), Positives = 96/299 (32%), Gaps = 93/299 (31%)
Query: 191 PTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTG 250
P W + GPW CS C G R RK S + L +RC
Sbjct: 876 PQQFYWNSHGPWQACSKPCQG-------ERKRKLVCTRESDQ--------LTVSDQRCDR 920
Query: 251 LP-PCPVAGGWGP-----W--GPVSPCPVTCGLGQTMEQRTC------------------ 284
LP P + G W S C CGLG C
Sbjct: 921 LPQPGHITEPCGTDCDLRWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFC 980
Query: 285 -NHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQ 343
+HP P + C+G+ CNT G W + W+ C S SC G
Sbjct: 981 SSHPKPSNREK-CSGE------CNT-------GGW-RYSAWTEC------SKSCD--GGT 1017
Query: 344 QSRGRTC---RGRKFDGHRCAGQQQ-DIRHCYSIQHCP--LKGSWSEWSTWGLCMPPCGP 397
Q R C R D +C Q++ I+ C CP G WSE C+ CG
Sbjct: 1018 QRRRAICVNTRNDVLDDSKCTHQEKVTIQRCSEFP-CPQWKSGDWSE------CLVTCGK 1070
Query: 398 -----------NPTRARQRLCTPLLPKYPPTVSMVEGQGEKNVTFWGRPLPRCEELQGQ 445
R R+C P+ PT SM Q + ++ P +C GQ
Sbjct: 1071 GHKHRQVWCQFGEDRLNDRMCD---PETKPT-SMQTCQQPECASWQAGPWGQCSVTCGQ 1125
Score = 32.0 bits (71), Expect = 1.2
Identities = 16/59 (27%), Positives = 23/59 (38%), Gaps = 1/59 (1%)
Query: 74 PCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQC 132
P W WS + CS TC G + R C + GK G + ++C + C
Sbjct: 585 PVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGR-RMKFKSCNTEPC 642
Score = 29.6 bits (65), Expect = 6.1
Identities = 47/206 (22%), Positives = 70/206 (33%), Gaps = 43/206 (20%)
Query: 189 VCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPC--PGLAYEQR 246
+ PT + W+ CS E +T +C EP +P P PG+ Y
Sbjct: 462 MAPTLNFYTNPWMWSKCSRKYIT---EFLDTGYGECLLNEPESRPYPLPVQLPGILYNVN 518
Query: 247 RCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGG------PFCAG-D 299
+ C + +GP V P + C + CN+ H G P+ G +
Sbjct: 519 K-----QCELI--FGPGSQVCPYMMQC------RRLWCNNVNGVHKGCRTQHTPWADGTE 565
Query: 300 ATRTHICNTAVPCP-------VDGEWDSWGEWSPCIRRNMKSI-----SCQEIPGQQSRG 347
C P DG W SW + C R I C P ++ G
Sbjct: 566 CEPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNR-PEPKNGG 624
Query: 348 RTCRGRKF-----DGHRCAGQQQDIR 368
+ C GR+ + C Q++D R
Sbjct: 625 KYCVGRRMKFKSCNTEPCLKQKRDFR 650
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 84.0 bits (206), Expect = 3e-16
Identities = 103/420 (24%), Positives = 146/420 (34%), Gaps = 107/420 (25%)
Query: 71 LCQPCR---SPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGT-------- 119
+ QPC P+W L W+PC+VTC +G + R C+ G +G +P T
Sbjct: 428 IAQPCNIFDCPKW-LAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEEC 486
Query: 120 ------------------LEW--QLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTR 159
L W Q Q E+ E + W C+VTC GT+ R
Sbjct: 487 IVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEA-WSACTVTCGVGTQVR 545
Query: 160 RRAC-----------NHPAPKC------------GGHCPGQAQESEACDTQQVCPTHGAW 196
C + P +C G C G+ E +T + +
Sbjct: 546 IVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDF 605
Query: 197 ATWGPW-----TPCSASCHGGPHEP------KETRS-RKCSAPEPSQKPPGKPCPGLAYE 244
W T CS SC GG E K+TR + + S++PP +
Sbjct: 606 DELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPP---------Q 656
Query: 245 QRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGP--FCAGDATR 302
+ L PCP G W SPC +TCG+G C+H + + A + R
Sbjct: 657 LLKSCNLDPCPARWEIGKW---SPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCR 713
Query: 303 THICNTAVPCPVDGEWDSW--GEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGH-- 358
+T C +W +W PC R +C G Q R C+ R DG
Sbjct: 714 QPKPSTVQACNRFNCPPAWYPAQWQPCSR------TCG--GGVQKREVLCKQRMADGSFL 765
Query: 359 -----RCAGQQQDIRHCYSIQHCPLKGSWSEW--STWGLCMPPCGPNPTRARQRLCTPLL 411
C+ + + CP SEW S W C CG T+ R +C +L
Sbjct: 766 ELPETFCSASKPACQQACKKDDCP-----SEWLLSDWTECSTSCGEG-TQTRSAICRKML 819
Score = 58.5 bits (140), Expect = 1e-08
Identities = 65/227 (28%), Positives = 76/227 (33%), Gaps = 65/227 (28%)
Query: 38 ESSGKCKGLLGGGVS-VEDCCLNTAFAYQKRSGGLCQPCRSP--------------RWSL 82
E KC GGGV CLN + LC R P RW +
Sbjct: 614 EGFTKCSESCGGGVQEAVVSCLNKQ-TREPAEENLCVTSRRPPQLLKSCNLDPCPARWEI 672
Query: 83 WSTWAPCSVTCSEGSQLRYRRC-----------VGWNGQCSGKVAPGTLEWQLQACEDQQ 131
W+PCS+TC G Q R C V + + P T +QAC
Sbjct: 673 -GKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPST----VQACNRFN 727
Query: 132 CCPEMGGWSGWGP--WEPCSVTCSKGTRTRRRACNH----------PAPKCGGHCPGQAQ 179
C P W P W+PCS TC G + R C P C P
Sbjct: 728 CPP------AWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKP---- 777
Query: 180 ESEACDTQQVCPTHGAWATW--GPWTPCSASCHGGPHEPKETRSRKC 224
AC QQ C + W WT CS SC G +TRS C
Sbjct: 778 ---AC--QQACKKDDCPSEWLLSDWTECSTSCGEG----TQTRSAIC 815
Score = 45.4 bits (106), Expect = 1e-04
Identities = 33/123 (26%), Positives = 45/123 (36%), Gaps = 24/123 (19%)
Query: 110 QCSGKVAPGTL----EWQLQACEDQQCCPEMGG-WSGWGPWEPCSVTCSKGTRTRRRACN 164
+C + PGTL + L + + + G W WGPW CS TC G R C
Sbjct: 2 ECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRC- 60
Query: 165 HPAPKCGGH-----------CPGQAQE--SEACDTQQVCPTHGAWATW-----GPWTPCS 206
+ C G CP +A + ++ C HG + W P PCS
Sbjct: 61 LSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCS 120
Query: 207 ASC 209
C
Sbjct: 121 LKC 123
Score = 43.9 bits (102), Expect = 3e-04
Identities = 60/217 (27%), Positives = 78/217 (35%), Gaps = 55/217 (25%)
Query: 78 PRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACED----QQC- 132
PRW + W CS +C G Q R CV + Q G V EW+ Q C
Sbjct: 378 PRWEA-TPWTACSSSCGGGIQSRAVSCVEEDIQ--GHVT-SVEEWKCMYTPKMPIAQPCN 433
Query: 133 ---CPEMGGWSGWGPWEPCSVTCSKGTRTRRRAC-NHPAPKCGGHCP-GQAQESEACDTQ 187
CP+ W W PC+VTC +G R R C +H GG P + E C
Sbjct: 434 IFDCPK---WLAQ-EWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEEC--- 486
Query: 188 QVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRR 247
+ P TPC ++PKE P ++ P K L E+
Sbjct: 487 -IVP-----------TPC--------YKPKE------KLPVEAKLPWFKQAQEL--EEGA 518
Query: 248 CTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTC 284
P + W S C VTCG+G + C
Sbjct: 519 AVSEEPSFIPEAW------SACTVTCGVGTQVRIVRC 549
Score = 42.4 bits (98), Expect = 0.001
Identities = 27/98 (27%), Positives = 38/98 (38%), Gaps = 18/98 (18%)
Query: 76 RSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGK-----------VAPGTLEWQL 124
R W W W+ CS TC G+ RRC+ + C G+ P +++
Sbjct: 32 RDGLWDAWGPWSECSRTCGGGASYSLRRCLS-SKSCEGRNIRYRTCSNVDCPPEAGDFRA 90
Query: 125 QACEDQQCCPEMGGWSGW-----GPWEPCSVTC-SKGT 156
Q C G + W P PCS+ C +KGT
Sbjct: 91 QQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGT 128
Score = 40.0 bits (92), Expect = 0.005
Identities = 28/99 (28%), Positives = 38/99 (38%), Gaps = 28/99 (28%)
Query: 194 GAWATWGPWTPCSASCHGGPH------------EPKETRSRKCSAPEPSQKPPGKPCPGL 241
G W WGPW+ CS +C GG E + R R CS + CP
Sbjct: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVD---------CPPE 84
Query: 242 A--YEQRRCTGLPPCPVAGGWGPWGPVS-----PCPVTC 273
A + ++C+ G + W PVS PC + C
Sbjct: 85 AGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKC 123
Score = 37.7 bits (86), Expect = 0.023
Identities = 27/84 (32%), Positives = 35/84 (41%), Gaps = 21/84 (25%)
Query: 315 DGEWDSWGEWSPC-----------IRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQ 363
DG WD+WG WS C +RR + S SC+ G+ R RTC C +
Sbjct: 33 DGLWDAWGPWSECSRTCGGGASYSLRRCLSSKSCE---GRNIRYRTC-----SNVDCPPE 84
Query: 364 QQDIRHCYSIQHCPLK--GSWSEW 385
D R H +K G + EW
Sbjct: 85 AGDFRAQQCSAHNDVKHHGQFYEW 108
Score = 34.3 bits (77), Expect = 0.25
Identities = 20/56 (35%), Positives = 22/56 (39%), Gaps = 7/56 (12%)
Query: 258 GGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCP 313
G W WGP S C TCG G + R C C G R C+ V CP
Sbjct: 34 GLWDAWGPWSECSRTCGGGASYSLRRC------LSSKSCEGRNIRYRTCSN-VDCP 82
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 82.8 bits (203), Expect = 6e-16
Identities = 99/412 (24%), Positives = 135/412 (32%), Gaps = 117/412 (28%)
Query: 54 EDCCLNTAFAYQKRSGGLCQPCRSPRWSLW--STWAPCSVTCSEGSQLRYRRC------V 105
+ C L K L + + W +W PCSV+C G+Q RY C +
Sbjct: 1127 QSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRI 1186
Query: 106 GWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRAC-N 164
C+ P + W C G W G W PCS +C G TR+ C N
Sbjct: 1187 ADESYCAHLPRPAEI-W--------DCFTPCGEWQA-GDWSPCSASCGHGKTTRQVLCMN 1236
Query: 165 HPAPKCGGHCPGQAQE--SEACDTQQVCPTH----------------------------- 193
+ P +C + + + C P H
Sbjct: 1237 YHQPIDENYCDPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNEN 1296
Query: 194 ---------GAWATWGPWTPCSASCHGGPHEP----KETRSRKCSAPEPSQKPPGKPCPG 240
W T GPW CS+SC GG ++ + S + + KPP
Sbjct: 1297 QVVHPSVRGNQWRT-GPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPP------ 1349
Query: 241 LAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDA 300
E ++C G PCP +G WG C TCG G C P G
Sbjct: 1350 ---ELQQC-GPGPCP-QWNYGNWG---ECSQTCGGGIKSRLVICQFP---------NGQI 1392
Query: 301 TRTHICNTA-----------VPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRT 349
H C CP D W W+ C S SC + G++ R
Sbjct: 1393 LEDHNCEIVNKPPSVIQCHMHACPADVSWHQ-EPWTSC------SASCGK--GRKYREVF 1443
Query: 350 CRG---RKFDGHRCAGQQQDIRH--CYSIQHCPLKGSWSEWSTWGLCMPPCG 396
C RK + C+ Q+ H C S++ CP SW ++W C CG
Sbjct: 1444 CIDQFQRKLEDTNCSQVQKPPTHKACRSVR-CP---SWKA-NSWNECSVTCG 1490
Score = 79.0 bits (193), Expect = 9e-15
Identities = 73/275 (26%), Positives = 107/275 (38%), Gaps = 42/275 (15%)
Query: 75 CRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQC-- 132
C RW +S W+ CS +C G + R C+ G ++A + +L + C
Sbjct: 965 CVFTRWH-YSEWSQCSRSCGGGERSRESYCMNNFGH---RLADNECQ-ELSRVTRENCNE 1019
Query: 133 --CPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVC 190
CP W+ W C VTC KGT+ R+ C G S ++ C
Sbjct: 1020 FSCPS---WAA-SEWSECLVTCGKGTKQRQVWCQLNVDHLS---DGFCNSSTKPESLSPC 1072
Query: 191 PTHGAWATW--GPWTPCSASC-HGGPHEP------------KETRSRKCSAPEPSQKPPG 235
H A+W GPW PC+ +C HG ++T + S P Q
Sbjct: 1073 ELH-TCASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVL 1131
Query: 236 KPCPGLAYEQRRCTGLPPCPVAGGWGPW--GPVSPCPVTCGLGQTMEQRTCNHPVPQHGG 293
PC ++ + T L P + W G +PC V+CG G +C + +
Sbjct: 1132 TPC---SFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIAD 1188
Query: 294 -PFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPC 327
+CA I + PC GEW + G+WSPC
Sbjct: 1189 ESYCAHLPRPAEIWDCFTPC---GEWQA-GDWSPC 1219
Score = 78.6 bits (192), Expect = 1e-14
Identities = 92/388 (23%), Positives = 126/388 (32%), Gaps = 89/388 (22%)
Query: 74 PCRSPRWSLWST--WAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQ 131
PC + W W PC+ TC G Q+R +CV + + V T + D+Q
Sbjct: 1071 PCELHTCASWQVGPWGPCTTTCGHGYQMRDVKCV---NELASAVLEDTECHEASRPSDRQ 1127
Query: 132 CC---------------------PEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKC 170
C +M W G W PCSV+C +GT+ R +C +
Sbjct: 1128 SCVLTPCSFISKLETALLPTVLIKKMAQWR-HGSWTPCSVSCGRGTQARYVSCRDALDRI 1186
Query: 171 G--GHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGP----------HEP-- 216
+C + +E D C G W G W+PCSASC G H+P
Sbjct: 1187 ADESYCAHLPRPAEIWDCFTPC---GEWQA-GDWSPCSASCGHGKTTRQVLCMNYHQPID 1242
Query: 217 --------KETRSRKCS---APEPSQKPPGKPCPGLAY-----------EQRRCTGLPPC 254
+ ++CS P P P Y E + P
Sbjct: 1243 ENYCDPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPS 1302
Query: 255 PVAGGW--GPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFC--AGDATRTHICNTAV 310
W GPWG C +C G C Q +C A C
Sbjct: 1303 VRGNQWRTGPWG---SCSSSCSGGLQHRAVVCQDENGQ-SASYCDAASKPPELQQCGPG- 1357
Query: 311 PCPVDGEWDSWGEWSPCIRRNMKS--ISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIR 368
PCP + +WGE S +KS + CQ GQ C + +
Sbjct: 1358 PCP-QWNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNC--------EIVNKPPSVI 1408
Query: 369 HCYSIQHCPLKGSWSEWSTWGLCMPPCG 396
C+ + CP SW + W C CG
Sbjct: 1409 QCH-MHACPADVSWHQ-EPWTSCSASCG 1434
Score = 68.2 bits (165), Expect = 2e-11
Identities = 68/231 (29%), Positives = 84/231 (36%), Gaps = 55/231 (23%)
Query: 77 SPRWSLWST--WAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCP 134
S R + W T W CS +CS G Q R C NGQ + + +LQ C C P
Sbjct: 1302 SVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPC-P 1360
Query: 135 EMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDT-------- 186
+ W+ +G W CS TC G ++R C P GQ E C+
Sbjct: 1361 Q---WN-YGNWGECSQTCGGGIKSRLVICQFP--------NGQILEDHNCEIVNKPPSVI 1408
Query: 187 ---QQVCPTHGAWATWGPWTPCSASCHGG---------PHEPKETRSRKCSAPEPSQKPP 234
CP +W PWT CSASC G ++ CS QKPP
Sbjct: 1409 QCHMHACPADVSWHQ-EPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCS---QVQKPP 1464
Query: 235 -GKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTC 284
K C + RC P A W + C VTCG G C
Sbjct: 1465 THKACRSV-----RC----PSWKANSW------NECSVTCGSGVQQRDVYC 1500
Score = 62.8 bits (151), Expect = 7e-10
Identities = 28/59 (47%), Positives = 32/59 (54%), Gaps = 1/59 (1%)
Query: 255 PVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCP 313
PV G WGPW P S C TCG G R CN P P++GG +C G + CNT CP
Sbjct: 554 PVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTD-SCP 611
Score = 52.4 bits (124), Expect = 9e-07
Identities = 24/54 (44%), Positives = 31/54 (57%), Gaps = 5/54 (9%)
Query: 142 WGPWEP---CSVTCSKGTRTRRRACNHPAPKCGG-HCPGQAQESEACDTQQVCP 191
WGPWEP CS TC G + R CN P P+ GG +C G+ + +C+T CP
Sbjct: 559 WGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDS-CP 611
Score = 48.9 bits (115), Expect = 1e-05
Identities = 42/151 (27%), Positives = 58/151 (38%), Gaps = 28/151 (18%)
Query: 108 NGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPA 167
N QC PG+ Q C C + W + KG T+ H
Sbjct: 486 NKQCELAFGPGS-----QMCPHINICMHL--------WCTSTEKLHKGCFTQ-----HVP 527
Query: 168 PKCGGHC-PGQAQESEACDTQQV--CPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKC 224
P G C PG C ++ P +G W W P++ CS +C GG E+ +R+C
Sbjct: 528 PADGTDCGPGMHCRHGLCVNKETETRPVNGEWGPWEPYSSCSRTCGGG----IESATRRC 583
Query: 225 SAPEPSQKPPGKPCPGLAYEQRRCTGLPPCP 255
+ PEP + G C G + R C CP
Sbjct: 584 NRPEP--RNGGNYCVGRRMKFRSC-NTDSCP 611
Score = 42.7 bits (99), Expect = 7e-04
Identities = 60/260 (23%), Positives = 81/260 (31%), Gaps = 84/260 (32%)
Query: 135 EMGGWSGWGPWEPCSVTCSKGTRTRRRACNH---------------PAP-----KCGGHC 174
+M W +GPWE C+ C +G + R C H P P C C
Sbjct: 846 DMFTWDPYGPWEGCTKMC-QGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTDC 904
Query: 175 P------GQAQESEAC-----------------------------------DTQQVCPTH 193
G+++ S C TQ++C +
Sbjct: 905 ELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGN 964
Query: 194 GAWATW--GPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGL 251
+ W W+ CS SC GG + +R C + C L+ R
Sbjct: 965 CVFTRWHYSEWSQCSRSCGGG----ERSRESYC-MNNFGHRLADNECQELSRVTRENCNE 1019
Query: 252 PPCP--VAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTA 309
CP A W S C VTCG G Q C V FC +T+ +
Sbjct: 1020 FSCPSWAASEW------SECLVTCGKGTKQRQVWCQLNVDHLSDGFC-NSSTKP---ESL 1069
Query: 310 VPCPVDGEWDSW--GEWSPC 327
PC + SW G W PC
Sbjct: 1070 SPCELH-TCASWQVGPWGPC 1088
Score = 33.1 bits (74), Expect = 0.56
Identities = 46/188 (24%), Positives = 70/188 (37%), Gaps = 31/188 (16%)
Query: 202 WTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPC--PGLAYEQRRCTGLPPCPVAGG 259
W+ CS E +T +C +P ++ P PG Y+ G C +A
Sbjct: 443 WSNCSRKY---VTEFLDTGYGECLLDKPDEEIYNLPSELPGSRYD-----GNKQCELA-- 492
Query: 260 WGPWGPVSP-----CPVTCGLGQTMEQRTCNHPVPQHGGPFCA-GDATRTHIC--NTAVP 311
+GP + P + C + + + VP G C G R +C
Sbjct: 493 FGPGSQMCPHINICMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGMHCRHGLCVNKETET 552
Query: 312 CPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCR--GRKFDGHRCAGQQQDIRH 369
PV+GEW W +S C R +C G +S R C + G+ C G++ R
Sbjct: 553 RPVNGEWGPWEPYSSCSR------TCG--GGIESATRRCNRPEPRNGGNYCVGRRMKFRS 604
Query: 370 CYSIQHCP 377
C + CP
Sbjct: 605 C-NTDSCP 611
Score = 29.3 bits (64), Expect = 8.0
Identities = 14/53 (26%), Positives = 21/53 (39%), Gaps = 1/53 (1%)
Query: 80 WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQC 132
W W ++ CS TC G + RRC + G G + ++C C
Sbjct: 559 WGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGR-RMKFRSCNTDSC 610
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1 motif,
16 preproprotein [Homo sapiens]
Length = 1224
Score = 79.0 bits (193), Expect = 9e-15
Identities = 90/317 (28%), Positives = 122/317 (38%), Gaps = 57/317 (17%)
Query: 48 GGGVSVEDCC-------LNTAFAYQKRSG--GLCQPCR----SPRWSLWSTWAPCSVTCS 94
GG ++V + C +N +F K GL PC+ P WS+ W+ CS TC
Sbjct: 887 GGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLV-PCKVSACPPSWSV-GNWSACSRTCG 944
Query: 95 EGSQLRYRRC---VGWNGQ-CSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSV 150
G+Q R +C V ++ + + P QAC Q C P WS GPW CS
Sbjct: 945 GGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQSCPP---AWSA-GPWAECSH 1000
Query: 151 TCSKGTRTRRRACNHPAPKCGGH------CPGQAQE--SEACDTQQV-CPTHGAWATWGP 201
TC KG R R AC P C + + EAC Q+ P W
Sbjct: 1001 TCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLV-SA 1059
Query: 202 WTPCSASCHGGPHEP-------------KETRSRKCS-APEPSQKPPGKPCPGLAYEQRR 247
W+ CS +C G + +E S+KCS P+PS + + C L
Sbjct: 1060 WSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELE-RACAPLP----- 1113
Query: 248 CTGLPPCPVAG-GWGPW--GPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTH 304
C PP AG G W P S C +CG G C G + +
Sbjct: 1114 CPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQKPSASL 1173
Query: 305 ICNTAVPCPVDGEWDSW 321
CNT CP+ + D++
Sbjct: 1174 ACNTHF-CPIAEKKDAF 1189
Score = 62.4 bits (150), Expect = 9e-10
Identities = 32/96 (33%), Positives = 41/96 (42%), Gaps = 14/96 (14%)
Query: 253 PCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPC 312
P P G W W SPC TCG G + R C +P P HGG FC G +CN+ C
Sbjct: 582 PKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQ-KC 640
Query: 313 PVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGR 348
P D + ++ C E ++ RGR
Sbjct: 641 PRDSV-------------DFRAAQCAEHNSRRFRGR 663
Score = 58.2 bits (139), Expect = 2e-08
Identities = 33/94 (35%), Positives = 41/94 (43%), Gaps = 13/94 (13%)
Query: 110 QCSGKVAP---GTLEWQLQACEDQQCC--------PEMGGWSGWGPWEPCSVTCSKGTRT 158
+C K P GT+ C QC P G WS W W PCS TC G
Sbjct: 549 KCETKFMPAAEGTICGHDMWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSH 608
Query: 159 RRRACNHPAPKCGG-HCPGQAQESEACDTQQVCP 191
R R C +P P GG C G + + C++Q+ CP
Sbjct: 609 RSRLCTNPKPSHGGKFCEGSTRTLKLCNSQK-CP 641
Score = 55.8 bits (133), Expect = 8e-08
Identities = 33/93 (35%), Positives = 39/93 (41%), Gaps = 14/93 (15%)
Query: 163 CNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSR 222
C H GG C E PTHG W+ W W+PCS +C GG RSR
Sbjct: 563 CGHDMWCRGGQCVKYGDEGPK-------PTHGHWSDWSSWSPCSRTCGGGVSH----RSR 611
Query: 223 KCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCP 255
C+ P+PS GK C G + C CP
Sbjct: 612 LCTNPKPSH--GGKFCEGSTRTLKLCNS-QKCP 641
Score = 52.8 bits (125), Expect = 7e-07
Identities = 68/305 (22%), Positives = 98/305 (32%), Gaps = 56/305 (18%)
Query: 148 CSVTCSKGTRTRRRACNHPA--PKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPC 205
CSV+C G T R C C + + +V +W+ G W+ C
Sbjct: 881 CSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSV-GNWSAC 939
Query: 206 SASCHGGPHEPKETRSRKCS--APEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPW 263
S +C GG ++R +C+ S+ P CP A R+ CP A GPW
Sbjct: 940 SRTCGGG----AQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPW 995
Query: 264 GPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPF-----CAGD-ATRTHICNTAVPC--PVD 315
+ C TCG G C P C + R H C P
Sbjct: 996 ---AECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKK 1052
Query: 316 GEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQH 375
+W WS C S++C+ G Q R C + G + H
Sbjct: 1053 LQW-LVSAWSQC------SVTCER--GTQKRFLKCAEKYVSGKYRELASKKCSHL----- 1098
Query: 376 CPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPL-LPKYPPTVSMVEGQGEKNVTFWGR 434
P P+ +R C PL P++PP + +G + W +
Sbjct: 1099 ---------------------PKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQ 1137
Query: 435 PLPRC 439
C
Sbjct: 1138 CTASC 1142
Score = 45.1 bits (105), Expect = 1e-04
Identities = 21/53 (39%), Positives = 26/53 (49%), Gaps = 1/53 (1%)
Query: 80 WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQC 132
WS WS+W+PCS TC G R R C GK G+ L+ C Q+C
Sbjct: 589 WSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTR-TLKLCNSQKC 640
Score = 39.7 bits (91), Expect = 0.006
Identities = 51/169 (30%), Positives = 61/169 (36%), Gaps = 25/169 (14%)
Query: 239 PGLAYEQRRCT-GLPPCPVAGGWGPWGPV-SPCPVTCGLGQTMEQRTCNHPVP-QHGGPF 295
PG+A+E G P A W V S C V+CG GQ + C + Q F
Sbjct: 849 PGVAWEYSMPRLGTEKQPPAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDLKFQVNMSF 908
Query: 296 CAGDATRTHICNTAVPCPVDGEWDSW--GEWSPCIRRNMKSISCQEIPGQQSRGRTCRGR 353
C +T VPC V SW G WS C R +C G QSR C R
Sbjct: 909 C---NPKTRPVTGLVPCKVSACPPSWSVGNWSACSR------TCG--GGAQSRPVQCTRR 957
Query: 354 -KFDGH-----RCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCG 396
+D C R + Q CP +WS W C CG
Sbjct: 958 VHYDSEPVPASLCPQPAPSSRQACNSQSCP--PAWSA-GPWAECSHTCG 1003
Score = 37.7 bits (86), Expect = 0.023
Identities = 16/38 (42%), Positives = 20/38 (52%), Gaps = 1/38 (2%)
Query: 377 PLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKY 414
P G WS+WS+W C CG + R RLCT P +
Sbjct: 584 PTHGHWSDWSSWSPCSRTCGGGVSH-RSRLCTNPKPSH 620
>gi|122937257 thrombospondin, type I, domain containing 7B [Homo
sapiens]
Length = 1577
Score = 76.6 bits (187), Expect = 4e-14
Identities = 91/366 (24%), Positives = 135/366 (36%), Gaps = 51/366 (13%)
Query: 74 PCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQC- 132
PC S+W S C +G Q R C+ + + S ++ + Q+C
Sbjct: 776 PCILVPESVWQGITGSSEACGKGLQTRAVSCISDDNR-SAEMMECLKQTNGMPLLVQECT 834
Query: 133 --CPEMGGWSGWGPWEPCSVTCSKGTRTRRRAC---NHPAPKCGGHCPGQAQESEACDTQ 187
C E ++ W + PCS C + T++RRR + KC E+E C
Sbjct: 835 VPCREDCTFTAWSKFTPCSTNC-EATKSRRRQLTGKSRKKEKCQDSDLYPLVETELCPCD 893
Query: 188 QVCPTHGAWATWGPWTPCSASCHGGPHEPK-----ETRSRKCS------APEPSQKPPGK 236
+ +G W+ C G EP + S++C A S K G+
Sbjct: 894 EFIS-----QPYGNWSDCILP--EGRREPHRGLRVQADSKECGEGLRFRAVACSDK-NGR 945
Query: 237 P-----CPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQH 291
P C Y Q +C + PCP W C +CG+G + + P +
Sbjct: 946 PVDPSFCSSSGYIQEKC--VIPCPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEK-PYN 1002
Query: 292 GGPFCAG-DATRTHICNTAVPCPVDGEWDSW--GEWSPC-IRRNMKSISCQEIPGQQSRG 347
GG C D + AVPC + SW WS C I ++S+ C G QSR
Sbjct: 1003 GGRPCPKLDLKNQAQVHEAVPCYSECNQYSWVVEHWSSCKINNELRSLRCG--GGTQSRK 1060
Query: 348 RTC------RGRKFDGHRCAGQQ--QDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNP 399
C G D + C + + + C + CP + SEW W C C P+
Sbjct: 1061 IRCVNTADGEGGAVDSNLCNQDEIPPETQSCSLM--CPNECVMSEWGLWSKCPQSCDPHT 1118
Query: 400 TRARQR 405
+ R R
Sbjct: 1119 MQRRTR 1124
Score = 75.9 bits (185), Expect = 7e-14
Identities = 103/378 (27%), Positives = 135/378 (35%), Gaps = 66/378 (17%)
Query: 57 CLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQL---RYR-RCVGWNGQCS 112
CL +F +S + + C + S WS+W+PCS TC GS L R R R V
Sbjct: 288 CLQDSFPLTVQSCIMPKDCET---SQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGG 344
Query: 113 GKVAPGTLEWQLQACEDQ--QCCPEMGGWSGWGPWEPCSVT----------------CSK 154
GK P LE + E + Q CP W W+ C V+ C
Sbjct: 345 GKECPELLEKEACIVEGELLQQCPRY-SWR-TSEWKECQVSLLLEQQDPHWHVTGPVCGG 402
Query: 155 GTRTRRRACNHPAPKCG-------------GHCPGQAQ-ESEACDTQQVCPTHGAWATWG 200
G +TR C P C G A S+ C+ C T ++W
Sbjct: 403 GIQTREVYCAQSVPAAAALRAKEVSRPVEKALCVGPAPLPSQLCNIP--CSTDCIVSSWS 460
Query: 201 PWTPC-SASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPC--PVA 257
W C +CH P K R+R+ S P G CP L PC P+
Sbjct: 461 AWGLCIHENCH-DPQGKKGFRTRQRHVLMESTGPAGH-CPHLVES-------VPCEDPMC 511
Query: 258 GGW-GPWGPVSPCPVTCGLGQTMEQRTC-NHPVPQHGGPFC-AGDATRTHICNTAVPCPV 314
W G P CGLG + + C N G C C +PC +
Sbjct: 512 YRWLASEGICFPDHGKCGLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSCE--IPCRM 569
Query: 315 DGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHR-CAGQQQDIRHCYSI 373
D W EWS C +S S + G+Q+R RT +G + C Q H
Sbjct: 570 DCVLSEWTEWSSC----SQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHRLCN 625
Query: 374 QHCPLKGSWSEWSTWGLC 391
H ++ W E S WG C
Sbjct: 626 DHSCMQLHW-ETSPWGPC 642
Score = 70.9 bits (172), Expect = 2e-12
Identities = 99/410 (24%), Positives = 145/410 (35%), Gaps = 75/410 (18%)
Query: 49 GGVSVEDCCLNTAFAYQKRSGGLCQP--CRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVG 106
GG + C + +S L P C W LWS C +C + R R +
Sbjct: 1071 GGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEWGLWSK---CPQSCDPHTMQRRTRHLL 1127
Query: 107 WNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVT----CSKGTRTRRRA 162
S A + Q+Q C + C + W C ++ C +G RTR +
Sbjct: 1128 RPSLNSRTCAEDS---QVQPCLLNENCFQFQ--YNLTEWSTCQLSENAPCGQGVRTRLLS 1182
Query: 163 CNHPAPKCGGHCPGQAQESEACDTQQV----------CPTHGAWATWGPWTPCSASC-HG 211
C C P + E + ++ C + + W WT CS +C HG
Sbjct: 1183 C-----VCSDGKPVSMDQCEQHNLEKPQRMSIPCLVECVVNCQLSGWTAWTECSQTCGHG 1237
Query: 212 GPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCP--VAGGWGPWGPVSPC 269
G + +R+R P + G+PCP +++ C + PC V G W S C
Sbjct: 1238 G----RMSRTRFIIMPTQGE---GRPCPTELTQEKTCP-VTPCYSWVLGNW------SAC 1283
Query: 270 PVT---CGLGQTMEQRTC-------NHPVPQHGGPFCAG----DATRTHICNTAVPCPVD 315
+ CG G + +C +H + C D+ +C+ VPCP D
Sbjct: 1284 KLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSILKQLCS--VPCPGD 1341
Query: 316 GEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGH-RCAGQQQDIRHCY--S 372
W EWS C + S + + G+QSR RT + F+ C Q + R C
Sbjct: 1342 CHLTEWSEWSTCELTCIDGRSFETV-GRQSRSRTFIIQSFENQDSCPQQVLETRPCTGGK 1400
Query: 373 IQHCPLKGS---------WSEWSTWGLCMPPCGPNPTRARQRLCTPLLPK 413
H K S W + S C P A R C P K
Sbjct: 1401 CYHYTWKASLWNNNERTVWCQRSDGVNVTGGCSPQARPAAIRQCIPACRK 1450
Score = 67.0 bits (162), Expect = 3e-11
Identities = 92/385 (23%), Positives = 126/385 (32%), Gaps = 90/385 (23%)
Query: 75 CRSPRWSLWSTWAPCS-----------------VTCSEGSQLRYRRCVGWN-GQ-----C 111
C W S W PCS TC G Q R CV + GQ C
Sbjct: 629 CMQLHWET-SPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRC 687
Query: 112 SGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRT----RRRACNHPA 167
P T+ C+ + C + + W PC C G T R R A
Sbjct: 688 PDSTRPETVRPCFLPCK-KDCIV-----TAFSEWTPCPRMCQAGNATVKQSRYRIIIQEA 741
Query: 168 PKCGGHCPGQAQESEACDTQQVCPTHGAWATWGP--WTPC--------------SASCHG 211
G CP E C+ +CP + W P W+PC S +C
Sbjct: 742 ANGGQECPDTLYEERECEDVSLCPVY----RWKPQKWSPCILVPESVWQGITGSSEACGK 797
Query: 212 GPHEPKETRSRKCSAPEPSQKPPG---KPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSP 268
G +TR+ C + + K G+ + CT PC + W +P
Sbjct: 798 G----LQTRAVSCISDDNRSAEMMECLKQTNGMPLLVQECT--VPCREDCTFTAWSKFTP 851
Query: 269 CPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDS--WGEWSP 326
C C ++ ++ + D+ + T + CP D E+ S +G WS
Sbjct: 852 CSTNCEATKSRRRQLTGKSRKKEK----CQDSDLYPLVETEL-CPCD-EFISQPYGNWSD 905
Query: 327 CI------------RRNMKSISCQEIPGQQSRGRTC---RGRKFDGHRCAGQQQDIRHCY 371
CI R S C E G + R C GR D C+ C
Sbjct: 906 CILPEGRREPHRGLRVQADSKECGE--GLRFRAVACSDKNGRPVDPSFCSSSGYIQEKC- 962
Query: 372 SIQHCPLKGSWSEWSTWGLCMPPCG 396
+ CP S+WS+WG C CG
Sbjct: 963 -VIPCPFDCKLSDWSSWGSCSSSCG 986
Score = 60.1 bits (144), Expect = 4e-09
Identities = 99/430 (23%), Positives = 139/430 (32%), Gaps = 93/430 (21%)
Query: 32 CFTQYEESSGKCKGLLGGGVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSV 91
C T E + + + L G E C + Y LC PC + W+ C +
Sbjct: 852 CSTNCEATKSRRRQLTGKSRKKEKC--QDSDLYPLVETELC-PCDEFISQPYGNWSDCIL 908
Query: 92 TCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACED------------------QQC- 132
EG + +R G Q K L ++ AC D ++C
Sbjct: 909 P--EGRREPHR---GLRVQADSKECGEGLRFRAVACSDKNGRPVDPSFCSSSGYIQEKCV 963
Query: 133 --CPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCP-----GQAQESEACD 185
CP S W W CS +C G R R + G CP QAQ EA
Sbjct: 964 IPCPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHEAVP 1023
Query: 186 TQQVCPTHGAWATWGPWTPC-------SASCHGGPHEPKETRSRKCSAPEPSQKPPGKPC 238
C + +W W+ C S C GG T+SRK + G
Sbjct: 1024 CYSECNQY-SWVV-EHWSSCKINNELRSLRCGGG------TQSRKIRCVNTADGEGGAVD 1075
Query: 239 PGLAYEQRRCTGLPP--------CPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQ 290
L + +PP CP WG S CP +C TM++RT + P
Sbjct: 1076 SNLCNQDE----IPPETQSCSLMCPNECVMSEWGLWSKCPQSCD-PHTMQRRTRHLLRPS 1130
Query: 291 HGGPFCAGDATRTHICNTAVPCPVDGEWDSW----GEWSPC-----------IRRNMKSI 335
CA D + PC ++ + EWS C +R + S
Sbjct: 1131 LNSRTCAED-------SQVQPCLLNENCFQFQYNLTEWSTCQLSENAPCGQGVRTRLLSC 1183
Query: 336 SCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPC 395
C S G+ + + H Q+ C + C + S W+ W C C
Sbjct: 1184 VC-------SDGKPVSMDQCEQHNLEKPQRMSIPC--LVECVVNCQLSGWTAWTECSQTC 1234
Query: 396 GPNPTRARQR 405
G +R R
Sbjct: 1235 GHGGRMSRTR 1244
Score = 52.4 bits (124), Expect = 9e-07
Identities = 84/354 (23%), Positives = 120/354 (33%), Gaps = 70/354 (19%)
Query: 91 VTCSEGSQLRYRRCVGWNGQCSGKVAPGTL--EWQLQACEDQQC---CPEMGGWSGWGPW 145
VT G Q R RC+ + + V + + LQ +Q C CP S + PW
Sbjct: 101 VTAQHGLQHRMVRCIQ---KLNRTVVANEICEHFALQPPTEQACLIPCPRDCVVSEFLPW 157
Query: 146 EPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATW----GP 201
CS C K + R RA P G CP ES ACD CP T+ GP
Sbjct: 158 SNCSKGCGKKLQHRTRAVIAPPLFGGLQCP-NLTESRACDAPISCPLGEEEYTFSLKVGP 216
Query: 202 WTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWG 261
W+ C PH + S + S +Y+ + W
Sbjct: 217 WSKCRL-----PHLKEINPSGRTVLDFNSDSNERVTFKHQSYKAHH--------HSKSW- 262
Query: 262 PWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGG-PFCAGDATRTHICNTAVPCPVDGEWDS 320
+G Q +C Q+ C D+ + + + P D E
Sbjct: 263 ----------AIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIM--PKDCETSQ 310
Query: 321 WGEWSPCIRRNMKSISCQE---IPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCY----SI 373
W WSPC S +C+ +PG +SR R + G + + + C +
Sbjct: 311 WSSWSPC------SKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEGELL 364
Query: 374 QHCPLKGSW--SEWST-------------WGLCMPPCGPNPTRARQRLCTPLLP 412
Q CP + SW SEW W + P CG + R+ C +P
Sbjct: 365 QQCP-RYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCG-GGIQTREVYCAQSVP 416
Score = 37.7 bits (86), Expect = 0.023
Identities = 64/314 (20%), Positives = 102/314 (32%), Gaps = 69/314 (21%)
Query: 143 GPWEPCSVTCSKG-TRTRRRACNHPAPKCG--GHCPGQAQESEACDTQQVCPTHGAWATW 199
GPW C+ C G ++R C H +C + + +VC H W
Sbjct: 16 GPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFRVCDWHSDLFQW 75
Query: 200 ---------------GPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYE 244
G P +A C H + R +C + C A +
Sbjct: 76 EVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQH-RMVRCIQKLNRTVVANEICEHFALQ 134
Query: 245 ---QRRCTGLPPCP---VAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAG 298
++ C L PCP V + PW S G G+ ++ RT P G
Sbjct: 135 PPTEQAC--LIPCPRDCVVSEFLPWSNCSK-----GCGKKLQHRTRAVIAPPLFGGLQCP 187
Query: 299 DATRTHICNTAVPCPVDGEWDSW----GEWSPCIRRNMKSI-----SCQEIPGQQSRGRT 349
+ T + C+ + CP+ E ++ G WS C ++K I + + + T
Sbjct: 188 NLTESRACDAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDSNERVT 247
Query: 350 CRGRKFDGH--------------------RCAGQQQDIRHC------YSIQHC--PLKGS 381
+ + + H R GQ + C ++Q C P
Sbjct: 248 FKHQSYKAHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCE 307
Query: 382 WSEWSTWGLCMPPC 395
S+WS+W C C
Sbjct: 308 TSQWSSWSPCSKTC 321
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 75.1 bits (183), Expect = 1e-13
Identities = 83/298 (27%), Positives = 112/298 (37%), Gaps = 52/298 (17%)
Query: 15 PLLLLLTLPATGSDPVLCFTQYEESSGKCKGLLGGGVSVEDCCL-------NTAFAYQKR 67
P ++ T PAT E S C G G ++V+ CL N++F K
Sbjct: 861 PKVMNGTPPATKRPAYTWSIVQSECSVSCGG---GYINVKAICLRDQNTQVNSSFCSAKT 917
Query: 68 SG----GLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNG-----QCSGKVAPG 118
+C P + + W+ CS C+ G Q R +CV + P
Sbjct: 918 KPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPV 977
Query: 119 TLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPA----PKCGGHC 174
+ Q+QAC C P+ WS GPW CS TC +G R R C A P+
Sbjct: 978 STPTQVQACNSHACPPQ---WS-LGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTS 1033
Query: 175 PGQAQESEACDTQQVCPTHG--AWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQK 232
+ + E C + CP + W W+ CSA+C G + R KCS K
Sbjct: 1034 LPRPELQEGCVLGR-CPKNSRLQWVA-SSWSECSATCGLGVRK----REMKCSEKGFQGK 1087
Query: 233 P---PGKPC-----PGLAYEQ----RRCTGLPPCPVAGGWG--PWGPVSPCPVTCGLG 276
P + C P L E+ R C P + GW PW C VTCG G
Sbjct: 1088 LITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPW---QQCTVTCGGG 1142
Score = 60.8 bits (146), Expect = 2e-09
Identities = 27/62 (43%), Positives = 34/62 (54%), Gaps = 1/62 (1%)
Query: 251 LPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAV 310
L P P+ G W W S C TCG G ++R CN+P PQ+GG FC G + +CN
Sbjct: 583 LGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNIN- 641
Query: 311 PC 312
PC
Sbjct: 642 PC 643
Score = 56.6 bits (135), Expect = 5e-08
Identities = 37/123 (30%), Positives = 49/123 (39%), Gaps = 29/123 (23%)
Query: 110 QCSGKVAP---GTLEWQLQACEDQQCC--------PEMGGWSGWGPWEPCSVTCSKGTRT 158
+C K P GT+ C QC P G WS W W CS TC G +
Sbjct: 552 RCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKF 611
Query: 159 RRRACNHPAPKCGG-HCPGQAQESEACDTQ-----------QVC------PTHGAWATWG 200
+ R CN+P P+ GG CPG ++ + C+ Q C P G + W
Sbjct: 612 QERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFRGWFYQWK 671
Query: 201 PWT 203
P+T
Sbjct: 672 PYT 674
Score = 56.2 bits (134), Expect = 6e-08
Identities = 60/242 (24%), Positives = 86/242 (35%), Gaps = 37/242 (15%)
Query: 62 FAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQ------LRYRRCVGWNGQCSGKV 115
+A K G + P ++ + CSV+C G LR + + CS K
Sbjct: 858 YALPKVMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKT 917
Query: 116 APGTLEWQLQACEDQQCCPEMGGWSGW--GPWEPCSVTCSKGTRTRRRACNHPAPKCGGH 173
P T + + C + W G W CS C+ G ++R+ C P
Sbjct: 918 KPVT---------EPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEE 968
Query: 174 CPGQAQESEACDTQ-QVCPTHGAWATW--GPWTPCSASCHGGPHEPKETRSRKCSAPEPS 230
+ + TQ Q C +H W GPW+ CS +C G + + + P
Sbjct: 969 AVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPE 1028
Query: 231 QKPPGKPCPGLAYEQRRCTGLPPCP-------VAGGWGPWGPVSPCPVTCGLGQTMEQRT 283
+ P P L Q C L CP VA W S C TCGLG +
Sbjct: 1029 SQCTSLPRPEL---QEGCV-LGRCPKNSRLQWVASSW------SECSATCGLGVRKREMK 1078
Query: 284 CN 285
C+
Sbjct: 1079 CS 1080
Score = 45.1 bits (105), Expect = 1e-04
Identities = 22/64 (34%), Positives = 32/64 (50%), Gaps = 7/64 (10%)
Query: 191 PTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTG 250
P HG W+ W W+ CS +C GG + + R C+ P+P G CPG + + C
Sbjct: 587 PIHGQWSAWSKWSECSRTCGGG----VKFQERHCNNPKPQY--GGLFCPGSSRIYQLC-N 639
Query: 251 LPPC 254
+ PC
Sbjct: 640 INPC 643
Score = 45.1 bits (105), Expect = 1e-04
Identities = 37/138 (26%), Positives = 55/138 (39%), Gaps = 32/138 (23%)
Query: 70 GLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCV--GWNGQ--------CSGKVAPGT 119
G C +W + S+W+ CS TC G + R +C G+ G+ C P
Sbjct: 1046 GRCPKNSRLQW-VASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNL 1104
Query: 120 LEWQLQACEDQQCCPE------MGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGH 173
L+ +++ CP + GW PW+ C+VTC G +TR H
Sbjct: 1105 ---DLEETCNRRACPAHPVYNMVAGWYSL-PWQQCTVTCGGGVQTR-----------SVH 1149
Query: 174 CPGQAQESEACDTQQVCP 191
C Q + S +C Q P
Sbjct: 1150 CVQQGRPSSSCLLHQKPP 1167
Score = 43.9 bits (102), Expect = 3e-04
Identities = 23/83 (27%), Positives = 34/83 (40%), Gaps = 16/83 (19%)
Query: 79 RWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPG----------------TLEW 122
+WS WS W+ CS TC G + + R C Q G PG +L++
Sbjct: 591 QWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDF 650
Query: 123 QLQACEDQQCCPEMGGWSGWGPW 145
+ Q C + P G + W P+
Sbjct: 651 RAQQCAEYNSKPFRGWFYQWKPY 673
Score = 35.4 bits (80), Expect = 0.11
Identities = 23/89 (25%), Positives = 35/89 (39%), Gaps = 11/89 (12%)
Query: 311 PCPVDGEWDSWGEWSPCIRRNMKSISCQE----IPGQQSRGRTCRG-----RKFDGHRCA 361
P P+ G+W +W +WS C R + QE P Q G C G + + + C
Sbjct: 585 PRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCN 644
Query: 362 GQQQDIR--HCYSIQHCPLKGSWSEWSTW 388
D R C P +G + +W +
Sbjct: 645 ENSLDFRAQQCAEYNSKPFRGWFYQWKPY 673
Score = 34.7 bits (78), Expect = 0.19
Identities = 14/38 (36%), Positives = 19/38 (50%), Gaps = 1/38 (2%)
Query: 377 PLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKY 414
P+ G WS WS W C CG + ++R C P+Y
Sbjct: 587 PIHGQWSAWSKWSECSRTCG-GGVKFQERHCNNPKPQY 623
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 74.3 bits (181), Expect = 2e-13
Identities = 50/144 (34%), Positives = 58/144 (40%), Gaps = 40/144 (27%)
Query: 170 CGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEP 229
C GH G A C T+ H WA P P A C GG +C
Sbjct: 472 CSGHLNGHAM----CQTK-----HSPWADGTPCGPAQA-CMGG----------RC----- 506
Query: 230 SQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVP 289
L +Q + +P AGGWGPWGP C TCG G R C PVP
Sbjct: 507 -----------LHMDQLQDFNIPQ---AGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVP 552
Query: 290 QHGGPFCAGDATRTHICNTAVPCP 313
++GG +C G TR CNT CP
Sbjct: 553 RNGGKYCEGRRTRFRSCNTE-DCP 575
Score = 65.5 bits (158), Expect = 1e-10
Identities = 36/102 (35%), Positives = 47/102 (46%), Gaps = 15/102 (14%)
Query: 108 NGQCSGKVAP---GTLEWQLQACEDQQCC----------PEMGGWSGWGPWEPCSVTCSK 154
+ C K +P GT QAC +C P+ GGW WGPW CS TC
Sbjct: 479 HAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGG 538
Query: 155 GTRTRRRACNHPAPKCGG-HCPGQAQESEACDTQQVCPTHGA 195
G + R C P P+ GG +C G+ +C+T+ CPT A
Sbjct: 539 GVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTED-CPTGSA 579
Score = 34.3 bits (77), Expect = 0.25
Identities = 16/53 (30%), Positives = 21/53 (39%), Gaps = 1/53 (1%)
Query: 80 WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQC 132
W W W CS TC G Q R C + GK G + ++C + C
Sbjct: 523 WGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGR-RTRFRSCNTEDC 574
Score = 32.3 bits (72), Expect = 0.95
Identities = 32/141 (22%), Positives = 43/141 (30%), Gaps = 36/141 (25%)
Query: 273 CGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNM 332
C L + R C P +C+G +C T + W + +PC
Sbjct: 449 CQLTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQT--------KHSPWADGTPCG---- 496
Query: 333 KSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCM 392
P Q G C Q QD + P G W W WG C
Sbjct: 497 --------PAQACMGGRCLHMD--------QLQDF-------NIPQAGGWGPWGPWGDCS 533
Query: 393 PPCGPNPTRARQRLCTPLLPK 413
CG + R CT +P+
Sbjct: 534 RTCG-GGVQFSSRDCTRPVPR 553
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 71.6 bits (174), Expect = 1e-12
Identities = 80/302 (26%), Positives = 111/302 (36%), Gaps = 60/302 (19%)
Query: 77 SPRWSLWS--TWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTL-EWQLQACEDQQC- 132
SP +S WS +W+ CS C G Q R C + P + + Q + + + C
Sbjct: 276 SPGFS-WSHGSWSDCSAECGGGHQSRLVFCT-----IDHEAYPDHMCQRQPRPADRRSCN 329
Query: 133 ---CPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNH----------PAPKCGGHCPGQAQ 179
CPE W GPW PCS +C G+++R C +C G PG+
Sbjct: 330 LHPCPETKRWKA-GPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAG-LPGKPP 387
Query: 180 ESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKET---------RSRKCSAPEPS 230
+AC+ Q+ AW+ PW CS SC G + T + CS +
Sbjct: 388 AIQACNLQRC----AAWSP-EPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLED-- 440
Query: 231 QKPPGKPCPGLAYEQRRCTGLPPCPVAG--GW--GPWGPVSPCPVTCGLGQTMEQRTCNH 286
+ P +PC +E CP+ W G WG C +C G Q C
Sbjct: 441 RPPLTEPC---VHED--------CPLLSDQAWHVGTWG---LCSKSCSSGTRRRQVICAI 486
Query: 287 PVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSR 346
P H G CNT PC + E S + + QE P SR
Sbjct: 487 GPPSHCGSLQHSKPVDVEPCNTQ-PCHLPQEVPSMQDVHTPASNPWMPLGPQESPASDSR 545
Query: 347 GR 348
G+
Sbjct: 546 GQ 547
Score = 60.5 bits (145), Expect = 3e-09
Identities = 57/183 (31%), Positives = 72/183 (39%), Gaps = 50/183 (27%)
Query: 74 PC-RSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNG----------QCSGKVAPGTLEW 122
PC + RW WAPCS +C GSQ R C+ +G +C+G PG
Sbjct: 332 PCPETKRWKA-GPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAG--LPGKPP- 387
Query: 123 QLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESE 182
+QAC Q+C WS PW CSV+C G R R C G +
Sbjct: 388 AIQACNLQRC----AAWSP-EPWGECSVSCGVGVRKRSVTCRGER--------GSLLHTA 434
Query: 183 ACDTQ-----------QVCP--THGAWATWGPWTPCSASCHGGPHEPKETRSRK--CSAP 227
AC + + CP + AW G W CS SC G TR R+ C+
Sbjct: 435 ACSLEDRPPLTEPCVHEDCPLLSDQAWHV-GTWGLCSKSCSSG------TRRRQVICAIG 487
Query: 228 EPS 230
PS
Sbjct: 488 PPS 490
Score = 57.0 bits (136), Expect = 4e-08
Identities = 69/241 (28%), Positives = 86/241 (35%), Gaps = 55/241 (22%)
Query: 191 PTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTG 250
P+ G + G W+ CSA C GG H+ + P +P P RR
Sbjct: 275 PSPGFSWSHGSWSDCSAEC-GGGHQSRLVFCTIDHEAYPDHMCQRQPRPA----DRRSCN 329
Query: 251 LPPCPVAGGW--GPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPF--------CAG-- 298
L PCP W GPW +PC +CG G C + G CAG
Sbjct: 330 LHPCPETKRWKAGPW---APCSASCGGGSQSRSVYC---ISSDGAGIQEAVEEAECAGLP 383
Query: 299 ------DATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRG 352
A C P P WGE S+SC G + R TCRG
Sbjct: 384 GKPPAIQACNLQRCAAWSPEP-------WGEC---------SVSCG--VGVRKRSVTCRG 425
Query: 353 RKFD-GHRCAGQQQD---IRHCYSIQHCPLKGSWSEW--STWGLCMPPCGPNPTRARQRL 406
+ H A +D + + CPL S W TWGLC C + TR RQ +
Sbjct: 426 ERGSLLHTAACSLEDRPPLTEPCVHEDCPLL-SDQAWHVGTWGLCSKSCS-SGTRRRQVI 483
Query: 407 C 407
C
Sbjct: 484 C 484
Score = 52.0 bits (123), Expect = 1e-06
Identities = 98/408 (24%), Positives = 130/408 (31%), Gaps = 106/408 (25%)
Query: 76 RSPRWSLWSTWAPCSVTCSEGSQLRYR-----------RCVG---WNGQCSGKVAP-GTL 120
+S W WS W+PCS TC G R R CVG + C + P G
Sbjct: 25 QSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGPARSHRSCRTESCPDGAR 84
Query: 121 EWQLQACEDQQCCPEMGGWSGWGPW----EPCSVTC-SKGTR------------------ 157
+++ + C + G W P+ C + C KG
Sbjct: 85 DFRAEQCAEFDGAEFQGRRYRWLPYYSAPNKCELNCIPKGENFYYKHREAVVDGTPCEPG 144
Query: 158 ---------TRRRACNHPAP---------KCGGH---CPGQAQESEACD-TQQVCPTHGA 195
R C+H +CGG C A +A D ++ V G
Sbjct: 145 KRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDANDLSRAVKNVRGE 204
Query: 196 WATWGPWT--------PCSASCHGGPHEPKETRSRKCSAPEPSQKP------PGKPCPGL 241
+ G WT S H + + A P+ +P +P PG+
Sbjct: 205 YYLNGHWTIEAARALPAASTILHYERGAEGDLAPERLHARGPTSEPLVIELISQEPNPGV 264
Query: 242 AYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTC---NHPVPQHGGPFCAG 298
YE P + G W S C CG G C + P H
Sbjct: 265 HYEYHLPLRRPSPGFSWSHGSW---SDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPR 321
Query: 299 DATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDG- 357
A R CN PCP W + G W+PC S SC G QSR C G
Sbjct: 322 PADR-RSCNLH-PCPETKRWKA-GPWAPC------SASCG--GGSQSRSVYCISSDGAGI 370
Query: 358 ------HRCA---GQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCG 396
CA G+ I+ C ++Q C +WS WG C CG
Sbjct: 371 QEAVEEAECAGLPGKPPAIQAC-NLQRC---AAWSP-EPWGECSVSCG 413
Score = 49.3 bits (116), Expect = 7e-06
Identities = 102/410 (24%), Positives = 135/410 (32%), Gaps = 112/410 (27%)
Query: 42 KCKGLLGGGVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRY 101
+C GL G +++ C L A+ SP W CSV+C G + R
Sbjct: 378 ECAGLPGKPPAIQACNLQRCAAW------------SP-----EPWGECSVSCGVGVRKRS 420
Query: 102 RRCVGWNGQ------CSGKVAPGTLEWQLQACEDQQCCPEMGGWSGW--GPWEPCSVTCS 153
C G G CS + P E C + CP + W G W CS +CS
Sbjct: 421 VTCRGERGSLLHTAACSLEDRPPLTE----PCVHED-CPLLSD-QAWHVGTWGLCSKSCS 474
Query: 154 KGTRTRRRACN-HPAPKCGGHCPGQAQESEACDTQQV-------------CPTHGAWATW 199
GTR R+ C P CG + + E C+TQ P W
Sbjct: 475 SGTRRRQVICAIGPPSHCGSLQHSKPVDVEPCNTQPCHLPQEVPSMQDVHTPASNPWMPL 534
Query: 200 GP------------WT----PCSASCHGGPH-EPKETRSRKCSA--PEPS-QKPPGKPCP 239
GP W P + H G +P+ + SA P PS Q+PP
Sbjct: 535 GPQESPASDSRGQWWAAQEHPSARGDHRGERGDPRGDQGTHLSALGPAPSLQQPP----- 589
Query: 240 GLAYEQRRCTGLPPCPVAGGWGP----WGPVSPCP--VTCGLGQTMEQRTCNHPVPQHGG 293
Y+Q P+ G GP P CP T LG + + C Q
Sbjct: 590 ---YQQ---------PLRSGSGPHDCRHSPHGCCPDGHTASLGP--QWQGCPGAPCQQSR 635
Query: 294 PFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIP-GQQSRGRTCRG 352
C D C DS G P R ++ P QQ+ CRG
Sbjct: 636 YGCCPDRVSVAEGPHHAGCTKSYGGDSTG-GMPRSRAVASTVHNTHQPQAQQNEPSECRG 694
Query: 353 RKFD-------------GHRCAGQQQDIRHCYSIQHCPL---KGSWSEWS 386
+F G C GQ H Y ++ C L GS ++W+
Sbjct: 695 SQFGCCYDNVATAAGPLGEGCVGQPS---HAYPVR-CLLPSAHGSCADWA 740
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 71.2 bits (173), Expect = 2e-12
Identities = 111/469 (23%), Positives = 149/469 (31%), Gaps = 129/469 (27%)
Query: 72 CQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAP-------------- 117
C P+W + W+ C+VTC G + R C+ G+ G P
Sbjct: 474 CNLFDCPKW-IAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPI 532
Query: 118 ------------GTLEW--QLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRAC 163
L W Q Q E+ + E + PW CS TC G + R C
Sbjct: 533 PCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIP-EPWSACSTTCGPGVQVREVKC 591
Query: 164 -----------NHPAPKCGGHCPGQAQES----EACDTQ-----------QVCPTHGAWA 197
P +C G P E EACD + T W
Sbjct: 592 RVLLTFTQTETELPEEECEG--PKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWE 649
Query: 198 TWGPWTPCSASCHGGPHEP-------KETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTG 250
G +TPC+A+C GG E + ++ S + +PP +
Sbjct: 650 YAG-FTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPA---------MSQACN 699
Query: 251 LPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGP-FCAGDATRTHICNTA 309
PCP G WG PC TCG+G C HP P C +
Sbjct: 700 TEPCPPRWHVGSWG---PCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQ 756
Query: 310 VPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDG-------HRCAG 362
CP + EW C R +C G Q+R TCR DG C G
Sbjct: 757 FDCPPGWHIE---EWQQCSR------TCG--GGTQNRRVTCRQLLTDGSFLNLSDELCQG 805
Query: 363 QQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSMVE 422
+ + CP + +WS C CG R R+++C L K
Sbjct: 806 PKASSHKSCARTDCPPHLAVGDWSK---CSVSCGVGIQR-RKQVCQRLAAK--------- 852
Query: 423 GQGEKNVTFWGRPLP----RCEELQGQKLVVEEKRPCLHVPACKDPEEE 467
GR +P C +L G LV R C +P C + E
Sbjct: 853 ----------GRRIPLSEMMCRDLPGLPLV----RSC-QMPECSKIKSE 886
Score = 57.0 bits (136), Expect = 4e-08
Identities = 69/262 (26%), Positives = 92/262 (35%), Gaps = 46/262 (17%)
Query: 74 PCRSPRWSLWSTWAPCSVTCSE-GSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACE--DQ 130
P + P W W+ CS TC G++++ +CV NGQ + L+ L E +
Sbjct: 1422 PPQEPFWEP-GNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNI 1480
Query: 131 QCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQ--- 187
+ CP S W CSV+C +G +R+ C K G Q AC +
Sbjct: 1481 RDCPARWFTS---VWSQCSVSCGEGYHSRQVTCKRT--KANGTV--QVVSPRACAPKDRP 1533
Query: 188 ---QVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYE 244
+ C H W P C C G ++ R C + P L
Sbjct: 1534 LGRKPCFGHPC-VQWEPGNRCPGRCMGRAVRMQQ-RHTACQHNSSDSNCDDRKRPTL--- 1588
Query: 245 QRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNH-----PVPQHG------- 292
+R CT C V GPW PC CG G + C H PV +
Sbjct: 1589 RRNCTS-GACDVCWHTGPW---KPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKP 1644
Query: 293 -------GPFCAGDAT-RTHIC 306
GP C D T TH C
Sbjct: 1645 ISWRHCLGPSCDRDCTDTTHYC 1666
Score = 48.9 bits (115), Expect = 1e-05
Identities = 97/406 (23%), Positives = 124/406 (30%), Gaps = 107/406 (26%)
Query: 78 PRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACED----QQC- 132
PRW + W CSV+C G Q R CV G++ EW+ Q C
Sbjct: 420 PRWE-HNPWTACSVSCGGGIQRRSFVCV--EESMHGEILQ-VEEWKCMYAPKPKVMQTCN 475
Query: 133 ---CPEMGGWSGWGPWEPCSVTCSKGTRTRRRAC-NHPAPKCGGHCP------------- 175
CP+ W W C+VTC +G R R C NH GG P
Sbjct: 476 LFDCPK---WIAM-EWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIP 531
Query: 176 -------------------GQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEP 216
QAQE E PT PW+ CS +C G
Sbjct: 532 IPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTF----IPEPWSACSTTCGPG---- 583
Query: 217 KETRSRKC----SAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGG------------- 259
+ R KC + + + P + C G R L C +
Sbjct: 584 VQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSE 643
Query: 260 ----WGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATR-----THICNTAV 310
W + +PC TC G C H Q D + CNT
Sbjct: 644 TTYDW-EYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTE- 701
Query: 311 PCPVDGEWDSWGEWSPCIRRNMKSISCQEI----PGQ-QSRGRTCRGRKFDGHRCAGQQQ 365
PCP W G W PC I +++ PG+ + CR K + Q
Sbjct: 702 PCP--PRWHV-GSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFD 758
Query: 366 DIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLL 411
CP EW C CG T+ R+ C LL
Sbjct: 759 ----------CPPGWHIEEWQQ---CSRTCG-GGTQNRRVTCRQLL 790
Score = 45.8 bits (107), Expect = 8e-05
Identities = 30/105 (28%), Positives = 42/105 (40%), Gaps = 6/105 (5%)
Query: 315 DGEWDSWGEWSPCIRR--NMKSISCQE-IPGQQSRGRTCRGRKFDGHRCAGQQQDIR--H 369
DG WD+WG+WS C R S S + + G+ G+ R + H C +D R
Sbjct: 75 DGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQ 134
Query: 370 CYSIQHCPLKGSWSEW-STWGLCMPPCGPNPTRARQRLCTPLLPK 413
C + +G + EW + PC Q L L PK
Sbjct: 135 CSAYNDVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPK 179
Score = 45.4 bits (106), Expect = 1e-04
Identities = 26/91 (28%), Positives = 32/91 (35%), Gaps = 17/91 (18%)
Query: 137 GGWSGWGPWEPCSVTCSKGTRTRRRAC---------NHPAPKCGGH-CPGQAQE--SEAC 184
G W WG W CS TC G R C N C H CP A++ ++ C
Sbjct: 76 GNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQC 135
Query: 185 DTQQVCPTHGAWATW-----GPWTPCSASCH 210
G + W P PC+ CH
Sbjct: 136 SAYNDVQYQGHYYEWLPRYNDPAAPCALKCH 166
Score = 44.3 bits (103), Expect = 2e-04
Identities = 58/211 (27%), Positives = 79/211 (37%), Gaps = 61/211 (28%)
Query: 36 YEESSGKCKGLLGGGVSVEDCCLNTAFAYQKRSGGLCQPCRSP--------------RWS 81
+ S C G LG + C + Q+ S LC + P RW
Sbjct: 1433 WSHCSATC-GHLGARIQRPQCVMANG---QEVSEALCDHLQKPLAGFEPCNIRDCPARW- 1487
Query: 82 LWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPE---MGG 138
S W+ CSV+C EG R C A GT +Q + C P+ +G
Sbjct: 1488 FTSVWSQCSVSCGEGYHSR-------QVTCKRTKANGT----VQVVSPRACAPKDRPLGR 1536
Query: 139 WSGWG----PWEP---CSVTC-SKGTRTRRR--ACNHPAPKCGGHCPGQAQ-------ES 181
+G WEP C C + R ++R AC H + +C + + S
Sbjct: 1537 KPCFGHPCVQWEPGNRCPGRCMGRAVRMQQRHTACQHNS--SDSNCDDRKRPTLRRNCTS 1594
Query: 182 EACDTQQVCPTHGAWATWGPWTPCSASCHGG 212
ACD VC W T GPW PC+A+C G
Sbjct: 1595 GACD---VC-----WHT-GPWKPCTAACGRG 1616
Score = 43.1 bits (100), Expect = 5e-04
Identities = 38/147 (25%), Positives = 52/147 (35%), Gaps = 21/147 (14%)
Query: 39 SSGKCKGLLGGGVSVEDC-CLNTAFA------YQKRSGGLCQPCRS----PRWSLWSTWA 87
S G C G G+ D CL+ + Q C P W + W
Sbjct: 711 SWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHI-EEWQ 769
Query: 88 PCSVTCSEGSQLRYRRCV-----GWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGW 142
CS TC G+Q R C G S ++ G ++C C P +
Sbjct: 770 QCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAV---- 825
Query: 143 GPWEPCSVTCSKGTRTRRRACNHPAPK 169
G W CSV+C G + R++ C A K
Sbjct: 826 GDWSKCSVSCGVGIQRRKQVCQRLAAK 852
Score = 38.9 bits (89), Expect = 0.010
Identities = 25/88 (28%), Positives = 33/88 (37%), Gaps = 15/88 (17%)
Query: 80 WSLWSTWAPCSVTCSEGSQLRYRRCV---GWNGQ------CSGKVAPGTLE-WQLQACED 129
W W W+ CS TC G+ RRC+ GQ CS P E ++ Q C
Sbjct: 78 WDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQCSA 137
Query: 130 QQCCPEMGGWSGW-----GPWEPCSVTC 152
G + W P PC++ C
Sbjct: 138 YNDVQYQGHYYEWLPRYNDPAAPCALKC 165
Score = 36.2 bits (82), Expect = 0.066
Identities = 23/90 (25%), Positives = 33/90 (36%), Gaps = 10/90 (11%)
Query: 194 GAWATWGPWTPCSASCHGGPHEP--KETRSRKCSAPEPSQKP-PGKPCPGLA--YEQRRC 248
G W WG W+ CS +C GG + R C K CP A + ++C
Sbjct: 76 GNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQC 135
Query: 249 TGLPPCPVAGGWGPW-----GPVSPCPVTC 273
+ G + W P +PC + C
Sbjct: 136 SAYNDVQYQGHYYEWLPRYNDPAAPCALKC 165
Score = 35.0 bits (79), Expect = 0.15
Identities = 21/60 (35%), Positives = 23/60 (38%), Gaps = 7/60 (11%)
Query: 258 GGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGE 317
G W WG S C TCG G + R C G C G R C+ CP D E
Sbjct: 76 GNWDAWGDWSDCSRTCGGGASYSLRRC------LTGRNCEGQNIRYKTCSNH-DCPPDAE 128
Score = 35.0 bits (79), Expect = 0.15
Identities = 58/255 (22%), Positives = 82/255 (32%), Gaps = 71/255 (27%)
Query: 88 PCSVTCSEGSQLRYRRCVGW-------NGQC-----SGKVAPGTLEWQLQACEDQQCCPE 135
PC+VTC G QL CV + C + K P E + C E
Sbjct: 350 PCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKE 409
Query: 136 MGGWSGW--------GPWEPCSVTCSKGTRTRRRACNHPAP----------KCGGHCPGQ 177
+ + + PW CSV+C G + R C + KC + P +
Sbjct: 410 IMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKC-MYAP-K 467
Query: 178 AQESEACDTQQVCPTHGAWATWGPWTPCSASC-------------HGGPH------EPKE 218
+ + C+ CP W W+ C+ +C H G H + K
Sbjct: 468 PKVMQTCNLFD-CP---KWIAM-EWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKL 522
Query: 219 TRSRKCSAPEPSQKPPGK-----PCPGL----AYEQRRCTGLPPCPVAGGWGPWGPVSPC 269
+C P P KP K P L E+ R P + W S C
Sbjct: 523 HIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPW------SAC 576
Query: 270 PVTCGLGQTMEQRTC 284
TCG G + + C
Sbjct: 577 STTCGPGVQVREVKC 591
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1 motif,
19 preproprotein [Homo sapiens]
Length = 1207
Score = 70.9 bits (172), Expect = 2e-12
Identities = 50/145 (34%), Positives = 64/145 (44%), Gaps = 17/145 (11%)
Query: 73 QPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGW--NG---QCSGKVAPGTLEWQLQAC 127
QPC++ RW + + W PCS TC +G Q R C NG + + G Q C
Sbjct: 974 QPCQT-RWMM-TEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRC 1031
Query: 128 EDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQ 187
E Q C M W G W CSV C KG R R C +P KC + +E+E C+
Sbjct: 1032 EGQDC---MTVWEA-GVWSECSVKCGKGIRHRTVRCTNPRKKC--VLSTRPREAEDCEDY 1085
Query: 188 QVCPTHGAWATWGPWTPCSASCHGG 212
C W G W+ CS +C G
Sbjct: 1086 SKC---YVW-RMGDWSKCSITCGKG 1106
Score = 64.3 bits (155), Expect = 2e-10
Identities = 62/234 (26%), Positives = 80/234 (34%), Gaps = 50/234 (21%)
Query: 84 STWAPCSVTCSEGSQLRYRRC---------VGWNGQCSGKVAPGTLEWQLQACEDQQCCP 134
++W C TC G + C + N +C P E Q++ C +Q C
Sbjct: 922 TSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKP---EPQIRKCNEQPCQT 978
Query: 135 EMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPK----------CGGHCPGQAQESEAC 184
W W PCS TC KG ++R+ AC C G P AQ E
Sbjct: 979 R---WM-MTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQ 1034
Query: 185 DTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYE 244
D V W G W+ CS C G R+ +C+ P +P E
Sbjct: 1035 DCMTV------WEA-GVWSECSVKCGKGIRH----RTVRCTNPRKKCVLSTRP-----RE 1078
Query: 245 QRRCTGLPPCPVAGGW--GPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFC 296
C C V W G W S C +TCG G C H + G C
Sbjct: 1079 AEDCEDYSKCYV---WRMGDW---SKCSITCGKGMQSRVIQCMHKITGRHGNEC 1126
Score = 45.1 bits (105), Expect = 1e-04
Identities = 43/147 (29%), Positives = 56/147 (38%), Gaps = 29/147 (19%)
Query: 129 DQQC----------CPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCP-GQ 177
D+QC C EM G W C V K RT+ P G C G+
Sbjct: 566 DEQCQILFGPLASFCQEMQHVICTGLW--CKVEGEKECRTKL-----DPPMDGTDCDLGK 618
Query: 178 AQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKP 237
++ C ++ P H A W W+PCS +C G +R RKC P +
Sbjct: 619 WCKAGECTSRTSAPEHLA-GEWSLWSPCSRTCSAG----ISSRERKC----PGLDSEARD 669
Query: 238 CPGLAYEQRRCTGLPPCPVA-GGWGPW 263
C G + R C PPCP G+ W
Sbjct: 670 CNGPRKQYRICEN-PPCPAGLPGFRDW 695
Score = 44.7 bits (104), Expect = 2e-04
Identities = 21/60 (35%), Positives = 29/60 (48%), Gaps = 3/60 (5%)
Query: 83 WSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGW 142
WS W+PCS TCS G R R+C G + + P Q + CE+ C + G+ W
Sbjct: 639 WSLWSPCSRTCSAGISSRERKCPGLDSEARDCNGP---RKQYRICENPPCPAGLPGFRDW 695
Score = 34.3 bits (77), Expect = 0.25
Identities = 24/63 (38%), Positives = 29/63 (46%), Gaps = 10/63 (15%)
Query: 293 GPFC-AGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQE--IPGQQSRGRT 349
G +C AG+ T T+ P + GEW W SPC R IS +E PG S R
Sbjct: 617 GKWCKAGECTS----RTSAPEHLAGEWSLW---SPCSRTCSAGISSRERKCPGLDSEARD 669
Query: 350 CRG 352
C G
Sbjct: 670 CNG 672
Score = 34.3 bits (77), Expect = 0.25
Identities = 23/68 (33%), Positives = 27/68 (39%), Gaps = 8/68 (11%)
Query: 248 CTGLPPCP--VAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHI 305
CT P +AG W W SPC TC G + +R C P C G + I
Sbjct: 625 CTSRTSAPEHLAGEWSLW---SPCSRTCSAGISSRERKC--PGLDSEARDCNGPRKQYRI 679
Query: 306 CNTAVPCP 313
C PCP
Sbjct: 680 CENP-PCP 686
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 69.7 bits (169), Expect = 5e-12
Identities = 47/155 (30%), Positives = 57/155 (36%), Gaps = 41/155 (26%)
Query: 173 HCPGQAQESEA----CDT---QQVCPTHGAWATWGPWTPCSAS--CHGGPHEPKETRSRK 223
HCP + + C T + +C T W TPC C G P+E R
Sbjct: 462 HCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEEEVER- 520
Query: 224 CSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVA-GGWGPWGPVSPCPVTCGLGQTMEQR 282
P PVA GGW PWGP C TCG G R
Sbjct: 521 -----------------------------PKPVADGGWAPWGPWGECSRTCGGGVQFSHR 551
Query: 283 TCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGE 317
C P PQ+GG +C G + C+T CP DG+
Sbjct: 552 ECKDPEPQNGGRYCLGRRAKYQSCHTE-ECPPDGK 585
Score = 62.0 bits (149), Expect = 1e-09
Identities = 29/79 (36%), Positives = 40/79 (50%), Gaps = 12/79 (15%)
Query: 127 CEDQQCCPEM----------GGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGG-HCP 175
C + C PE GGW+ WGPW CS TC G + R C P P+ GG +C
Sbjct: 507 CSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCL 566
Query: 176 GQAQESEACDTQQVCPTHG 194
G+ + ++C T++ CP G
Sbjct: 567 GRRAKYQSCHTEE-CPPDG 584
Score = 45.1 bits (105), Expect = 1e-04
Identities = 34/128 (26%), Positives = 42/128 (32%), Gaps = 31/128 (24%)
Query: 133 CPEMGGWSGWGPWEPCSV--TCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVC 190
C G W PC CS+G+ P P G
Sbjct: 486 CHTKNGSLPWADGTPCGPGHLCSEGSCLPEEEVERPKPVADG------------------ 527
Query: 191 PTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTG 250
WA WGPW CS +C GG + R+C PEP G+ C G + + C
Sbjct: 528 ----GWAPWGPWGECSRTCGGG----VQFSHRECKDPEPQN--GGRYCLGRRAKYQSC-H 576
Query: 251 LPPCPVAG 258
CP G
Sbjct: 577 TEECPPDG 584
Score = 42.0 bits (97), Expect = 0.001
Identities = 19/63 (30%), Positives = 28/63 (44%), Gaps = 1/63 (1%)
Query: 73 QPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQC 132
+P W+ W W CS TC G Q +R C Q G+ G + Q+C ++C
Sbjct: 522 KPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGR-RAKYQSCHTEEC 580
Query: 133 CPE 135
P+
Sbjct: 581 PPD 583
Score = 37.4 bits (85), Expect = 0.029
Identities = 31/115 (26%), Positives = 40/115 (34%), Gaps = 29/115 (25%)
Query: 252 PPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVP 311
P C G PW +PC G G + +C +P+ P
Sbjct: 484 PLCHTKNGSLPWADGTPC----GPGHLCSEGSC---LPEE---------------EVERP 521
Query: 312 CPV-DGEWDSWGEWSPCIRR-----NMKSISCQEIPGQQSRGRTCRGRKFDGHRC 360
PV DG W WG W C R C++ P Q+ GR C GR+ C
Sbjct: 522 KPVADGGWAPWGPWGECSRTCGGGVQFSHRECKD-PEPQNGGRYCLGRRAKYQSC 575
Score = 36.2 bits (82), Expect = 0.066
Identities = 20/68 (29%), Positives = 28/68 (41%), Gaps = 1/68 (1%)
Query: 65 QKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQL 124
++ + + QP +W L W+ CS TC G Q R C +GQ S
Sbjct: 821 ERATTNIIQPLLHAQWVL-GDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDA 879
Query: 125 QACEDQQC 132
+ CE Q C
Sbjct: 880 KPCESQLC 887
Score = 33.5 bits (75), Expect = 0.43
Identities = 15/51 (29%), Positives = 26/51 (50%), Gaps = 3/51 (5%)
Query: 143 GPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPG--QAQESEACDTQQVCP 191
G W CS TC G + R C P+ + C + ++++ C++ Q+CP
Sbjct: 839 GDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCES-QLCP 888
>gi|223718260 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 68.9 bits (167), Expect = 9e-12
Identities = 60/225 (26%), Positives = 85/225 (37%), Gaps = 36/225 (16%)
Query: 74 PCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNG------QCSGKVAPGTLEWQLQAC 127
P RW L S+ PCS TC+ G Y CV ++G C P + + C
Sbjct: 562 PADMYRWKL-SSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVH---EFC 617
Query: 128 EDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRAC------NHPAPKCGGHCPGQAQES 181
++C P W W CS TC +G + R C + C +A E+
Sbjct: 618 AGRECQPR---WE-TSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLC--EAAEA 671
Query: 182 EACDTQQVCPTHGAWATW--GPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCP 239
+ ++ C W W+ C+A C TR +CS E P +P
Sbjct: 672 VRPEERKTCRNPACGPQWEMSEWSECTAKC---GERSVVTRDIRCSEDEKLCDPNTRP-- 726
Query: 240 GLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTC 284
++ CTG PPC WG PC +CG G+T+ C
Sbjct: 727 ---VGEKNCTG-PPCDRQWTVSDWG---PCSGSCGQGRTIRHVYC 764
Score = 51.6 bits (122), Expect = 2e-06
Identities = 74/295 (25%), Positives = 98/295 (33%), Gaps = 53/295 (17%)
Query: 68 SGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSG----------KVAP 117
+G CQP RW S+W+ CS TC EG Q R RC W G + A
Sbjct: 618 AGRECQP----RWET-SSWSECSRTCGEGYQFRVVRC--WKMLSPGFDSSVYSDLCEAAE 670
Query: 118 GTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTC-SKGTRTRRRACNHPAPKCGGHCPG 176
+ + C + C P+ W W C+ C + TR C+ C P
Sbjct: 671 AVRPEERKTCRNPACGPQ---WE-MSEWSECTAKCGERSVVTRDIRCSEDEKLCD---PN 723
Query: 177 QAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGG---PHEPKETRSRKCSAPEPSQKP 233
E T C + WG PCS SC G H +T + PE +
Sbjct: 724 TRPVGEKNCTGPPCDRQWTVSDWG---PCSGSCGQGRTIRHVYCKTSDGRV-VPESQCQM 779
Query: 234 PGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTC----NHPVP 289
KP + C P +A W C TCG G C N
Sbjct: 780 ETKPLAIHPCGDKNC---PAHWLAQDW------ERCNTTCGRGVKKRLVLCMELANGKPQ 830
Query: 290 QHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRR-----NMKSISCQE 339
GP C G A + +T P + S WS C + M+ + C +
Sbjct: 831 TRSGPEC-GLAKKPPEESTCFERPCFKWYTS--PWSECTKTCGVGVRMRDVKCYQ 882
Score = 38.5 bits (88), Expect = 0.013
Identities = 44/189 (23%), Positives = 56/189 (29%), Gaps = 22/189 (11%)
Query: 196 WATWGPWTPCSASCHGG--PHEPKETRSRKCSAPEPSQKP-----------PGKPCP--G 240
W W WT CS SC GG E + R+ S P P + + CP G
Sbjct: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
Query: 241 LAYEQRRCTGLPPCPVAGGWGPWGPVSP------CPVTCGLGQTMEQRTCNHPVPQHGGP 294
++ + +C G W P+ P C L T VP G
Sbjct: 110 RSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPARDGT 169
Query: 295 FC-AGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGR 353
C D + P DG S C SC + G +G G
Sbjct: 170 SCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAHLGY 229
Query: 354 KFDGHRCAG 362
H AG
Sbjct: 230 SLVTHIPAG 238
Score = 34.7 bits (78), Expect = 0.19
Identities = 18/61 (29%), Positives = 25/61 (40%), Gaps = 6/61 (9%)
Query: 139 WSGWGPWEPCSVTCSKGTRTRRRAC----NHPAPKCGGH-CPGQAQESEACDTQQVCPTH 193
W W W CS +C G ++ R C P G C G ++ + C Q+ CP
Sbjct: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQE-CPPD 108
Query: 194 G 194
G
Sbjct: 109 G 109
Score = 32.3 bits (72), Expect = 0.95
Identities = 16/60 (26%), Positives = 26/60 (43%), Gaps = 5/60 (8%)
Query: 80 WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQC----SGKVAPGTLEWQLQACEDQQCCPE 135
W W+ W CS +C G + R C+ + + GT + + Q C Q+C P+
Sbjct: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSK-RYQLCRVQECPPD 108
>gi|41281450 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 68.9 bits (167), Expect = 9e-12
Identities = 60/225 (26%), Positives = 85/225 (37%), Gaps = 36/225 (16%)
Query: 74 PCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNG------QCSGKVAPGTLEWQLQAC 127
P RW L S+ PCS TC+ G Y CV ++G C P + + C
Sbjct: 562 PADMYRWKL-SSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVH---EFC 617
Query: 128 EDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRAC------NHPAPKCGGHCPGQAQES 181
++C P W W CS TC +G + R C + C +A E+
Sbjct: 618 AGRECQPR---WE-TSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLC--EAAEA 671
Query: 182 EACDTQQVCPTHGAWATW--GPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCP 239
+ ++ C W W+ C+A C TR +CS E P +P
Sbjct: 672 VRPEERKTCRNPACGPQWEMSEWSECTAKC---GERSVVTRDIRCSEDEKLCDPNTRP-- 726
Query: 240 GLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTC 284
++ CTG PPC WG PC +CG G+T+ C
Sbjct: 727 ---VGEKNCTG-PPCDRQWTVSDWG---PCSGSCGQGRTIRHVYC 764
Score = 51.6 bits (122), Expect = 2e-06
Identities = 74/295 (25%), Positives = 98/295 (33%), Gaps = 53/295 (17%)
Query: 68 SGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSG----------KVAP 117
+G CQP RW S+W+ CS TC EG Q R RC W G + A
Sbjct: 618 AGRECQP----RWET-SSWSECSRTCGEGYQFRVVRC--WKMLSPGFDSSVYSDLCEAAE 670
Query: 118 GTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTC-SKGTRTRRRACNHPAPKCGGHCPG 176
+ + C + C P+ W W C+ C + TR C+ C P
Sbjct: 671 AVRPEERKTCRNPACGPQ---WE-MSEWSECTAKCGERSVVTRDIRCSEDEKLCD---PN 723
Query: 177 QAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGG---PHEPKETRSRKCSAPEPSQKP 233
E T C + WG PCS SC G H +T + PE +
Sbjct: 724 TRPVGEKNCTGPPCDRQWTVSDWG---PCSGSCGQGRTIRHVYCKTSDGRV-VPESQCQM 779
Query: 234 PGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTC----NHPVP 289
KP + C P +A W C TCG G C N
Sbjct: 780 ETKPLAIHPCGDKNC---PAHWLAQDW------ERCNTTCGRGVKKRLVLCMELANGKPQ 830
Query: 290 QHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRR-----NMKSISCQE 339
GP C G A + +T P + S WS C + M+ + C +
Sbjct: 831 TRSGPEC-GLAKKPPEESTCFERPCFKWYTS--PWSECTKTCGVGVRMRDVKCYQ 882
Score = 38.5 bits (88), Expect = 0.013
Identities = 44/189 (23%), Positives = 56/189 (29%), Gaps = 22/189 (11%)
Query: 196 WATWGPWTPCSASCHGG--PHEPKETRSRKCSAPEPSQKP-----------PGKPCP--G 240
W W WT CS SC GG E + R+ S P P + + CP G
Sbjct: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
Query: 241 LAYEQRRCTGLPPCPVAGGWGPWGPVSP------CPVTCGLGQTMEQRTCNHPVPQHGGP 294
++ + +C G W P+ P C L T VP G
Sbjct: 110 RSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPARDGT 169
Query: 295 FC-AGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGR 353
C D + P DG S C SC + G +G G
Sbjct: 170 SCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAHLGY 229
Query: 354 KFDGHRCAG 362
H AG
Sbjct: 230 SLVTHIPAG 238
Score = 34.7 bits (78), Expect = 0.19
Identities = 18/61 (29%), Positives = 25/61 (40%), Gaps = 6/61 (9%)
Query: 139 WSGWGPWEPCSVTCSKGTRTRRRAC----NHPAPKCGGH-CPGQAQESEACDTQQVCPTH 193
W W W CS +C G ++ R C P G C G ++ + C Q+ CP
Sbjct: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQE-CPPD 108
Query: 194 G 194
G
Sbjct: 109 G 109
Score = 32.3 bits (72), Expect = 0.95
Identities = 16/60 (26%), Positives = 26/60 (43%), Gaps = 5/60 (8%)
Query: 80 WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQC----SGKVAPGTLEWQLQACEDQQCCPE 135
W W+ W CS +C G + R C+ + + GT + + Q C Q+C P+
Sbjct: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSK-RYQLCRVQECPPD 108
>gi|169174934 PREDICTED: similar to ADAMTS-like 2 [Homo sapiens]
Length = 660
Score = 68.9 bits (167), Expect = 9e-12
Identities = 60/225 (26%), Positives = 85/225 (37%), Gaps = 36/225 (16%)
Query: 74 PCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNG------QCSGKVAPGTLEWQLQAC 127
P RW L S+ PCS TC+ G Y CV ++G C P + + C
Sbjct: 271 PADMYRWKL-SSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVH---EFC 326
Query: 128 EDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRAC------NHPAPKCGGHCPGQAQES 181
++C P W W CS TC +G + R C + C +A E+
Sbjct: 327 AGRECQPR---WE-TSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLC--EAAEA 380
Query: 182 EACDTQQVCPTHGAWATW--GPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCP 239
+ ++ C W W+ C+A C TR +CS E P +P
Sbjct: 381 VRPEERKTCRNPACGPQWEMSEWSECTAKC---GERSVVTRDIRCSEDEKLCDPNTRP-- 435
Query: 240 GLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTC 284
++ CTG PPC WG PC +CG G+T+ C
Sbjct: 436 ---VGEKNCTG-PPCDRQWTVSDWG---PCSGSCGQGRTIRHVYC 473
Score = 51.6 bits (122), Expect = 2e-06
Identities = 74/295 (25%), Positives = 98/295 (33%), Gaps = 53/295 (17%)
Query: 68 SGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSG----------KVAP 117
+G CQP RW S+W+ CS TC EG Q R RC W G + A
Sbjct: 327 AGRECQP----RWET-SSWSECSRTCGEGYQFRVVRC--WKMLSPGFDSSVYSDLCEAAE 379
Query: 118 GTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTC-SKGTRTRRRACNHPAPKCGGHCPG 176
+ + C + C P+ W W C+ C + TR C+ C P
Sbjct: 380 AVRPEERKTCRNPACGPQ---WE-MSEWSECTAKCGERSVVTRDIRCSEDEKLCD---PN 432
Query: 177 QAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGG---PHEPKETRSRKCSAPEPSQKP 233
E T C + WG PCS SC G H +T + PE +
Sbjct: 433 TRPVGEKNCTGPPCDRQWTVSDWG---PCSGSCGQGRTIRHVYCKTSDGRV-VPESQCQM 488
Query: 234 PGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTC----NHPVP 289
KP + C P +A W C TCG G C N
Sbjct: 489 ETKPLAIHPCGDKNC---PAHWLAQDW------ERCNTTCGRGVKKRLVLCMELANGKPQ 539
Query: 290 QHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRR-----NMKSISCQE 339
GP C G A + +T P + S WS C + M+ + C +
Sbjct: 540 TRSGPEC-GLAKKPPEESTCFERPCFKWYTS--PWSECTKTCGVGVRMRDVKCYQ 591
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.501
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,357,865
Number of Sequences: 37866
Number of extensions: 1630628
Number of successful extensions: 6896
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 77
Number of HSP's successfully gapped in prelim test: 139
Number of HSP's that attempted gapping in prelim test: 5124
Number of HSP's gapped (non-prelim): 903
length of query: 469
length of database: 18,247,518
effective HSP length: 106
effective length of query: 363
effective length of database: 14,233,722
effective search space: 5166841086
effective search space used: 5166841086
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.