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Search of human proteins with 223029510
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|223029510 echinoderm microtubule associated protein like 4
isoform b [Homo sapiens]
(923 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|223029510 echinoderm microtubule associated protein like 4 is... 1892 0.0
gi|19923497 echinoderm microtubule associated protein like 4 iso... 1725 0.0
gi|56790930 echinoderm microtubule associated protein like 1 iso... 938 0.0
gi|56790932 echinoderm microtubule associated protein like 1 iso... 930 0.0
gi|110227615 echinoderm microtubule associated protein like 3 [H... 867 0.0
gi|6912356 echinoderm microtubule associated protein like 2 [Hom... 818 0.0
gi|223005862 echinoderm microtubule associated protein like 6 [H... 384 e-106
gi|34485720 echinoderm microtubule associated protein like 5 [Ho... 365 e-100
gi|31377846 WD repeat domain 52 [Homo sapiens] 87 7e-17
gi|145279222 WD repeat domain 66 [Homo sapiens] 82 2e-15
gi|94400919 WD repeat domain 90 [Homo sapiens] 73 1e-12
gi|22749037 WD repeat domain 65 [Homo sapiens] 70 9e-12
gi|190684671 mitogen-activated protein kinase binding protein 1 ... 67 6e-11
gi|190684677 mitogen-activated protein kinase binding protein 1 ... 67 6e-11
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 62 3e-09
gi|145580608 WD repeat domain 62 isoform 1 [Homo sapiens] 61 5e-09
gi|145580610 WD repeat domain 62 isoform 2 [Homo sapiens] 61 5e-09
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 59 2e-08
gi|21071067 TBP-associated factor 5 [Homo sapiens] 57 6e-08
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 55 4e-07
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom... 55 4e-07
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 54 5e-07
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 54 5e-07
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 54 5e-07
gi|26665869 WD repeat domain 51B [Homo sapiens] 54 7e-07
gi|19913367 transducin beta-like 1Y [Homo sapiens] 54 9e-07
gi|19913365 transducin beta-like 1Y [Homo sapiens] 54 9e-07
gi|15150805 transducin beta-like 1Y [Homo sapiens] 54 9e-07
gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens] 53 1e-06
gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens] 53 1e-06
>gi|223029510 echinoderm microtubule associated protein like 4
isoform b [Homo sapiens]
Length = 923
Score = 1892 bits (4900), Expect = 0.0
Identities = 923/923 (100%), Positives = 923/923 (100%)
Query: 1 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVA 60
MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVA
Sbjct: 1 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVA 60
Query: 61 SVKKSVSSKGQPSPRAVIPMSCITNGSGANRKPSHTSAVSIAGKETLSSAAKSIKRPSPA 120
SVKKSVSSKGQPSPRAVIPMSCITNGSGANRKPSHTSAVSIAGKETLSSAAKSIKRPSPA
Sbjct: 61 SVKKSVSSKGQPSPRAVIPMSCITNGSGANRKPSHTSAVSIAGKETLSSAAKSIKRPSPA 120
Query: 121 EKSHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQEGEYIKMFMRGRPITM 180
EKSHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQEGEYIKMFMRGRPITM
Sbjct: 121 EKSHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQEGEYIKMFMRGRPITM 180
Query: 181 FIPSDVDNYDDIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGEIVYFIASVVVLFNYE 240
FIPSDVDNYDDIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGEIVYFIASVVVLFNYE
Sbjct: 181 FIPSDVDNYDDIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGEIVYFIASVVVLFNYE 240
Query: 241 ERTQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIG 300
ERTQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIG
Sbjct: 241 ERTQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIG 300
Query: 301 LGTFERGVGCLDFSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFH 360
LGTFERGVGCLDFSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFH
Sbjct: 301 LGTFERGVGCLDFSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFH 360
Query: 361 PTDANTIITCGKSHIFFWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGV 420
PTDANTIITCGKSHIFFWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGV
Sbjct: 361 PTDANTIITCGKSHIFFWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGV 420
Query: 421 MLIWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDH 480
MLIWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDH
Sbjct: 421 MLIWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDH 480
Query: 481 DLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGL 540
DLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGL
Sbjct: 481 DLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGL 540
Query: 541 ATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWF 600
ATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWF
Sbjct: 541 ATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWF 600
Query: 601 VLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCT 660
VLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCT
Sbjct: 601 VLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCT 660
Query: 661 GHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQ 720
GHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQ
Sbjct: 661 GHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQ 720
Query: 721 VFGVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVT 780
VFGVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVT
Sbjct: 721 VFGVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVT 780
Query: 781 NVSFTHNDSHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVSSTESVIQSNTP 840
NVSFTHNDSHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVSSTESVIQSNTP
Sbjct: 781 NVSFTHNDSHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVSSTESVIQSNTP 840
Query: 841 TPPPSQPLNETAEEESRISSSPTLLENSLEQTVEPSEDHSEEESEEGSGDLGEPLYEEPC 900
TPPPSQPLNETAEEESRISSSPTLLENSLEQTVEPSEDHSEEESEEGSGDLGEPLYEEPC
Sbjct: 841 TPPPSQPLNETAEEESRISSSPTLLENSLEQTVEPSEDHSEEESEEGSGDLGEPLYEEPC 900
Query: 901 NEISKEQAKATLLEDQQDPSPSS 923
NEISKEQAKATLLEDQQDPSPSS
Sbjct: 901 NEISKEQAKATLLEDQQDPSPSS 923
>gi|19923497 echinoderm microtubule associated protein like 4
isoform a [Homo sapiens]
Length = 981
Score = 1725 bits (4468), Expect = 0.0
Identities = 861/981 (87%), Positives = 880/981 (89%), Gaps = 58/981 (5%)
Query: 1 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQ---------------------EDEIT 39
MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQ ED +
Sbjct: 1 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVA 60
Query: 40 VLKAALAD--------VLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGANR 91
+K +++ V+ I+ A+ K S +S + + + + +
Sbjct: 61 SVKKSVSSKGQPSPRAVIPMSCITNGSGANRKPSHTSAVSIAGKETLSSAAKSGTEKKKE 120
Query: 92 KP---------SHTSAVSIAGKETLS--------------------SAAKSIKRPSPAEK 122
KP SH++ S + + S + KSIKRPSPAEK
Sbjct: 121 KPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEK 180
Query: 123 SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQEGEYIKMFMRGRPITMFI 182
SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQEGEYIKMFMRGRPITMFI
Sbjct: 181 SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQEGEYIKMFMRGRPITMFI 240
Query: 183 PSDVDNYDDIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGEIVYFIASVVVLFNYEER 242
PSDVDNYDDIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGEIVYFIASVVVLFNYEER
Sbjct: 241 PSDVDNYDDIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGEIVYFIASVVVLFNYEER 300
Query: 243 TQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLG 302
TQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLG
Sbjct: 301 TQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLG 360
Query: 303 TFERGVGCLDFSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPT 362
TFERGVGCLDFSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPT
Sbjct: 361 TFERGVGCLDFSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPT 420
Query: 363 DANTIITCGKSHIFFWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVML 422
DANTIITCGKSHIFFWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVML
Sbjct: 421 DANTIITCGKSHIFFWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVML 480
Query: 423 IWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDL 482
IWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDL
Sbjct: 481 IWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDL 540
Query: 483 NPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLAT 542
NPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLAT
Sbjct: 541 NPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLAT 600
Query: 543 HPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVL 602
HPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVL
Sbjct: 601 HPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVL 660
Query: 603 DAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCTGH 662
DAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCTGH
Sbjct: 661 DAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCTGH 720
Query: 663 SSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVF 722
SSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVF
Sbjct: 721 SSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVF 780
Query: 723 GVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNV 782
GVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNV
Sbjct: 781 GVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNV 840
Query: 783 SFTHNDSHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVSSTESVIQSNTPTP 842
SFTHNDSHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVSSTESVIQSNTPTP
Sbjct: 841 SFTHNDSHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVSSTESVIQSNTPTP 900
Query: 843 PPSQPLNETAEEESRISSSPTLLENSLEQTVEPSEDHSEEESEEGSGDLGEPLYEEPCNE 902
PPSQPLNETAEEESRISSSPTLLENSLEQTVEPSEDHSEEESEEGSGDLGEPLYEEPCNE
Sbjct: 901 PPSQPLNETAEEESRISSSPTLLENSLEQTVEPSEDHSEEESEEGSGDLGEPLYEEPCNE 960
Query: 903 ISKEQAKATLLEDQQDPSPSS 923
ISKEQAKATLLEDQQDPSPSS
Sbjct: 961 ISKEQAKATLLEDQQDPSPSS 981
>gi|56790930 echinoderm microtubule associated protein like 1
isoform b [Homo sapiens]
Length = 815
Score = 938 bits (2424), Expect = 0.0
Identities = 445/806 (55%), Positives = 592/806 (73%), Gaps = 20/806 (2%)
Query: 9 DDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSS 68
DDS SAAS+ +V DR+++LE RVQ QED+I +LK+ALADV+RRL I+E+ A + + +
Sbjct: 23 DDSASAASSMEVTDRIASLEQRVQMQEDDIQLLKSALADVVRRLNITEEQQAVLNRKGPT 82
Query: 69 KGQPSPRAVIPMSCITNGSGANRKPSHT-SAVSIAGKETLSSAAKS-IKRPSPAEKSHNS 126
K +P + + + + NG+ +KP+ + + S KET A KS IKR S +E+
Sbjct: 83 KARPLMQTLPLRTTVNNGTVLPKKPTGSLPSPSGVRKETAVPATKSNIKRTSSSERVSPG 142
Query: 127 W--ENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQEGEYIKMFMRGRPITMFIPS 184
E++ DSR ++ ST + K K+ + + E Y+KMF+RGRP+TM++P
Sbjct: 143 GRRESNGDSRGNRNRTGSTSSSSSGKKNSESKPKEPVFSAEEGYVKMFLRGRPVTMYMPK 202
Query: 185 D-VDNYD-DIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGEIVYFIASVVVLFNYEER 242
D VD+Y + + ELP ++LKLEW YGYRG+DCR N+YLLPTGE VYFIASVVVL+N EE+
Sbjct: 203 DQVDSYSLEAKVELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQ 262
Query: 243 TQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLG 302
QRHY GH D VKCLA+HPD+I IATGQ+AG KDG+ L PHVR+WDSVTL+TL +IG+G
Sbjct: 263 LQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIG 322
Query: 303 TFERGVGCLDFSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPT 362
F+R V C+ FSK++ G +LC +DDSN+H+L+VWDWQK+ K A++K +NE V A +FHPT
Sbjct: 323 FFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPT 382
Query: 363 DANTIITCGKSHIFFWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVML 422
D N I+TCGKSH++FWT G+SL +KQG+F K EKPKFV C+ F NGD +TGDS G +L
Sbjct: 383 DTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNIL 442
Query: 423 IWSKTTVEPTPGKGPKGVYQISKQIK-AHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHD 481
+W KG +IS ++ AH+G +F LC +R+G L++GGGKDRK+I W +
Sbjct: 443 VWG------------KGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGN 490
Query: 482 LNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLA 541
R+ E+P+Q+G IR VAEGK D L+GT+RNF+L+GT + F QGHTDELWGLA
Sbjct: 491 YQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTPITQGHTDELWGLA 550
Query: 542 THPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFV 601
H K LTC D+ LW+++ HR W +++++P + FHPSG+VVA+GT +GRWFV
Sbjct: 551 IHASKSQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFV 610
Query: 602 LDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCTG 661
D ET+DLV++HTDGNEQLSVMRYS DG FLA+GSHDN IY+Y VS+NGRKY+R G+C+G
Sbjct: 611 FDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSG 670
Query: 662 HSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQV 721
HSS+ITHLDWS ++++++SNSGDYEILYW +P+ CK + + +DI+W TYTC LGF V
Sbjct: 671 HSSFITHLDWSVNSQFLVSNSGDYEILYW-VPSACKQVVSVETTRDIEWATYTCTLGFHV 729
Query: 722 FGVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTN 781
FGVWPEGSDGTDINA+ R+H +K+++ DDF KVHLF YPCS+ +APSH Y HSSHVTN
Sbjct: 730 FGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAPSHIYGGHSSHVTN 789
Query: 782 VSFTHNDSHLISTGGKDMSIIQWKLV 807
V F DSHLISTGGKD SI+QW+++
Sbjct: 790 VDFLCEDSHLISTGGKDTSIMQWRVI 815
>gi|56790932 echinoderm microtubule associated protein like 1
isoform a [Homo sapiens]
Length = 834
Score = 930 bits (2403), Expect = 0.0
Identities = 443/825 (53%), Positives = 593/825 (71%), Gaps = 39/825 (4%)
Query: 9 DDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSS 68
DDS SAAS+ +V DR+++LE RVQ QED+I +LK+ALADV+RRL I+E+ A + + +
Sbjct: 23 DDSASAASSMEVTDRIASLEQRVQMQEDDIQLLKSALADVVRRLNITEEQQAVLNRKGPT 82
Query: 69 KGQPSPRAVIPMSCITNGSGANRKPSHT-SAVSIAGKETLSSAAKSIKR----------- 116
K +P + + + + NG+ +KP+ + + S KET A K + R
Sbjct: 83 KARPLMQTLPLRTTVNNGTVLPKKPTGSLPSPSGVRKETAVPATKRLNRSVSLLNACKLN 142
Query: 117 ---PSPAEKSHNSW--------ENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQE 165
PS +++ +S E++ DSR ++ ST + K K+ + + E
Sbjct: 143 RSTPSNIKRTSSSERVSPGGRRESNGDSRGNRNRTGSTSSSSSGKKNSESKPKEPVFSAE 202
Query: 166 GEYIKMFMRGRPITMFIPSD-VDNYD-DIRTELPPEKLKLEWAYGYRGKDCRANVYLLPT 223
Y+KMF+RGRP+TM++P D VD+Y + + ELP ++LKLEW YGYRG+DCR N+YLLPT
Sbjct: 203 EGYVKMFLRGRPVTMYMPKDQVDSYSLEAKVELPTKRLKLEWVYGYRGRDCRNNLYLLPT 262
Query: 224 GEIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQP 283
GE VYFIASVVVL+N EE+ QRHY GH D VKCLA+HPD+I IATGQ+AG KDG+ L P
Sbjct: 263 GETVYFIASVVVLYNVEEQLQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPP 322
Query: 284 HVRVWDSVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCVIDDSNEHMLTVWDWQKKAK 343
HVR+WDSVTL+TL +IG+G F+R V C+ FSK++ G +LC +DDSN+H+L+VWDWQK+ K
Sbjct: 323 HVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEK 382
Query: 344 GAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWTWSGNSLTRKQGIFGKYEKPKFVQC 403
A++K +NE V A +FHPTD N I+TCGKSH++FWT G+SL +KQG+F K EKPKFV C
Sbjct: 383 LADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKFVLC 442
Query: 404 LAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKGPKGVYQISKQIK-AHDGSVFTLCQMRN 462
+ F NGD +TGDS G +L+W KG +IS ++ AH+G +F LC +R+
Sbjct: 443 VTFSENGDTITGDSSGNILVWG------------KGTNRISYAVQGAHEGGIFALCMLRD 490
Query: 463 GMLLTGGGKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTF 522
G L++GGGKDRK+I W + R+ E+P+Q+G IR VAEGK D L+GT+RNF+L+GT
Sbjct: 491 GTLVSGGGKDRKLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTL 550
Query: 523 NDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCAD 582
+ F QGHTDELWGLA H K LTC D+ LW+++ HR W +++++P +
Sbjct: 551 SGDFTPITQGHTDELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSG 610
Query: 583 FHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIY 642
FHPSG+VVA+GT +GRWFV D ET+DLV++HTDGNEQLSVMRYS DG FLA+GSHDN IY
Sbjct: 611 FHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIY 670
Query: 643 LYVVSENGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNR 702
+Y VS+NGRKY+R G+C+GHSS+ITHLDWS ++++++SNSGDYEILYW +P+ CK + +
Sbjct: 671 IYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYW-VPSACKQVVSV 729
Query: 703 SDCKDIDWTTYTCVLGFQVFGVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPC 762
+DI+W TYTC LGF VFGVWPEGSDGTDINA+ R+H +K+++ DDF KVHLF YPC
Sbjct: 730 ETTRDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPC 789
Query: 763 SKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTGGKDMSIIQWKLV 807
S+ +APSH Y HSSHVTNV F DSHLISTGGKD SI+QW+++
Sbjct: 790 SQFRAPSHIYGGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI 834
>gi|110227615 echinoderm microtubule associated protein like 3 [Homo
sapiens]
Length = 896
Score = 867 bits (2240), Expect = 0.0
Identities = 448/908 (49%), Positives = 585/908 (64%), Gaps = 89/908 (9%)
Query: 1 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVA 60
MDG AG D ++ L +L R++ QE E+ ++KAALA+ LR L +
Sbjct: 1 MDGAAGPGD--------GPAREALQSLSQRLRVQEQEMELVKAALAEALRLLRLQVP--- 49
Query: 61 SVKKSVSSKGQPSPRAV-------IPMSC-------------------------ITNG-- 86
S+ G P+P +P +C ++NG
Sbjct: 50 --PSSLQGSGTPAPPGDSLAAPPGLPPTCTPSLVSRGTQTETEVELKSSPGPPGLSNGPP 107
Query: 87 --SGANRKPSHT------SAVSIAGKETLSSAAKSIKRP----SPAEKSHNSWENSDDSR 134
GA+ +PS T S+ S AG + ++ P +P S +S S+ R
Sbjct: 108 APQGASEEPSGTQSEGGGSSSSGAGSPGPPGILRPLQPPQRADTPRRNSSSSSSPSERPR 167
Query: 135 NKLSK--IPSTPKLIPKVTKTADKHKDVI------------INQEGEYIKMFMRGRPITM 180
KLS+ I S L+ + + KD + N EG +KMF+RGRPITM
Sbjct: 168 QKLSRKAISSANLLVRSGSTESRGGKDPLSSPGGPGSRRSNYNLEGISVKMFLRGRPITM 227
Query: 181 FIPSDVDNYDDIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGEIVYFIASVVVLFNYE 240
+IPS + + +++ + PPE L L+W YGYRG+D R+N+++L +GE+VYFIA VVVL+
Sbjct: 228 YIPSGIRSLEELPSGPPPETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPG 287
Query: 241 ERT-------QRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTL 293
QRHY GHTDCV+CLA+HPD +R+A+GQ AGVDKDG+PLQP V +WDS TL
Sbjct: 288 GGPGGPGGGGQRHYRGHTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETL 347
Query: 294 STLQIIGLGTFERGVGCLDFSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEV 353
LQ IGLG FERGVG L FS AD G LCV+DDSNEHML+VWD + K AEIK+TN+
Sbjct: 348 LKLQEIGLGAFERGVGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDS 407
Query: 354 VLAVEFHPTDANTIITCGKSHIFFWTWSGN-------SLTRKQGIFGKYEKPKFVQCLAF 406
VLAV F+P D++ I+T GKSH+ FW WSG +LTRKQG+FGKY+KPKF+ C F
Sbjct: 408 VLAVGFNPRDSSCIVTSGKSHVHFWNWSGGVGVPGNGTLTRKQGVFGKYKKPKFIPCFVF 467
Query: 407 LGNGDVLTGDSGGVMLIWSKTTVEP-TPGKG-PKGVYQISKQIKAHDGSVFTLCQMRNGM 464
L +GD+LTGDS G +L W ++ + TPG+G K Y I Q AH+GS+F LC R+G
Sbjct: 468 LPDGDILTGDSEGNILTWGRSPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLRRDGT 527
Query: 465 LLTGGGKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFND 524
+L+GGG+DR+++ W L +E E+P+ +G +RA+AEG + LVGT++N +LRG
Sbjct: 528 VLSGGGRDRRLVQWGPGLVALQEAEIPEHFGAVRAIAEGLGSELLVGTTKNALLRGDLAQ 587
Query: 525 GFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCADFH 584
GF +QGHTDELWGL THP ++ LTC DRQ+CLW+ H L W+ + E G CADFH
Sbjct: 588 GFSPVIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCADFH 647
Query: 585 PSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLY 644
PSG VVA+G ++GRW VLD ETR++VS DGNEQLSV+RYS DG +LA+GSHDN IY+Y
Sbjct: 648 PSGAVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIY 707
Query: 645 VVSENGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSD 704
VS +G K SR+GRC GHSS+ITHLDWS D +IMSNSGDYEILYWD+ GCK ++NR +
Sbjct: 708 SVSSDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNRYE 767
Query: 705 CKDIDWTTYTCVLGFQVFGVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSK 764
+D +W TYTCVLGF V+GVWP+GSDGTDIN+L RSHN +V+AVADDFCKVHLFQYPC++
Sbjct: 768 SRDREWATYTCVLGFHVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYPCAR 827
Query: 765 AKAPSHKYSAHSSHVTNVSFTHNDSHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLT 824
AKAPS Y H SHVT+V FTH+DSHL+S GGKD SI QW+++ T +
Sbjct: 828 AKAPSRMYGGHGSHVTSVRFTHDDSHLVSLGGKDASIFQWRVLGAGGAGPAPATPSRTPS 887
Query: 825 KAPVSSTE 832
+P SS +
Sbjct: 888 LSPASSLD 895
>gi|6912356 echinoderm microtubule associated protein like 2 [Homo
sapiens]
Length = 649
Score = 818 bits (2113), Expect = 0.0
Identities = 374/656 (57%), Positives = 495/656 (75%), Gaps = 14/656 (2%)
Query: 154 ADKHKDVIINQEGEYIKMFMRGRPITMFIPSDV-DNYD-DIRTELPPEKLKLEWAYGYRG 211
A K K+VI + E +KMF+RGRP+ M IP ++ Y D R+ELP +LKLEW YGYRG
Sbjct: 6 AGKTKEVIFSVEDGSVKMFLRGRPVPMMIPDELAPTYSLDTRSELPSCRLKLEWVYGYRG 65
Query: 212 KDCRANVYLLPTGEIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAIHPDKIRIATGQI 271
+DCRAN+YLLPTGEIVYF+ASV VL++ EE+ QRHYLGH D +KCLAIHPD + IATGQ+
Sbjct: 66 RDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAIHPDMVTIATGQV 125
Query: 272 AGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCVIDDSNEH 331
AG K+G+PL PHVR+WDSV+LSTL ++GLG F+R V C+ FSK++ G LC +D+SN+H
Sbjct: 126 AGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNGGNLLCAVDESNDH 185
Query: 332 MLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWTWSGNSLTRKQGI 391
ML+VWDW K+ K ++K +NE VL FHPTD +ITCGKSHI+FWT G SL+++QG+
Sbjct: 186 MLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLEGGSLSKRQGL 245
Query: 392 FGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKGPKGVYQISKQIKAHD 451
F K+EKPK+V C+ FL GDV+TGDSGG + +W GKG + Q + AHD
Sbjct: 246 FEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVW---------GKGGNRITQ--AVLGAHD 294
Query: 452 GSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVG 511
G VF LC +R+G L++GGG+DR+++LW D + +E+EVP+ +G +R VAEG D VG
Sbjct: 295 GGVFGLCALRDGTLVSGGGRDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVG 354
Query: 512 TSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWT 571
T+RN IL+G+ + GF + VQGH +ELWGLATHP + +TC QD+ V LW+S H+ W+
Sbjct: 355 TTRNSILQGSVHTGFSLLVQGHVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWS 414
Query: 572 RLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTF 631
R++++P A FHPSG+V+A+GT +GRW +LD ET DLV+IHTDGNEQ+SV+ +S DG +
Sbjct: 415 RIIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAY 474
Query: 632 LAVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWD 691
LAVGSHDN +Y+Y V + GRK SR G+C+GHSS+ITHLDW+ D+ ++NSGDYEILYWD
Sbjct: 475 LAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSSCFVTNSGDYEILYWD 534
Query: 692 IPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPEGSDGTDINALVRSHNRKVIAVADD 751
P CK I + ++++W T TCVLGF VFG+W EG+DGTDINA+ RSH+ K++A ADD
Sbjct: 535 -PATCKQITSADAVRNMEWATATCVLGFGVFGIWSEGADGTDINAVARSHDGKLLASADD 593
Query: 752 FCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTGGKDMSIIQWKLV 807
F KVHLF YPC + +A SHKY HSSHVTNV+F +DS ++TGGKD S++QW++V
Sbjct: 594 FGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMALTTGGKDTSVLQWRVV 649
>gi|223005862 echinoderm microtubule associated protein like 6 [Homo
sapiens]
Length = 1958
Score = 384 bits (987), Expect = e-106
Identities = 230/691 (33%), Positives = 364/691 (52%), Gaps = 47/691 (6%)
Query: 197 PPEKLKLEWAYGYRGKDCRANVYLLPTGEIVYFIASVVVLFNYEERTQRHYLGHTDCVKC 256
P +L+LEW YGYRG CR N+Y E+VYF+A V V++N E +Q+ +LGH D +
Sbjct: 7 PRCQLRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYNTREHSQKFFLGHNDDIIS 66
Query: 257 LAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLDFSKA 316
LA+HPDK +ATGQ+ +P++ +WDS + T+ ++ GV CL F
Sbjct: 67 LALHPDKTLVATGQVGK--------EPYICIWDSYNVQTVSLLK-DVHTHGVACLAFDS- 116
Query: 317 DSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIF 376
G L + ++ + +WDW+K A ++ + + + P N +++CG HI
Sbjct: 117 -DGQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIK 175
Query: 377 FWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKG 436
FWT GN+LT K+GIFGK + + CLA +G G + +W
Sbjct: 176 FWTLCGNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVW------------ 223
Query: 437 PKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPEREIEVPD-QYG 495
KG+ + AH +F++ G GG+D I LWD D P +I++ + + G
Sbjct: 224 -KGLNLVRTIQGAHSAGIFSMYACEEGFAT--GGRDGCIRLWDTDFKPITKIDLRETEQG 280
Query: 496 ----TIRAVAEGKADQFLVGTSRNFILRGTFN--DGFQIEVQGHTD-ELWGLATHPFKDL 548
+IR+V KAD+ L GT + I D + +QGH + ELW LA HP K L
Sbjct: 281 YKGLSIRSVC-WKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPL 339
Query: 549 LLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRD 608
+T + DR V LW+ +H L ++E F P G+ +A+G G + VL
Sbjct: 340 AVTGSDDRSVRLWSLADHALIARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMT 399
Query: 609 LVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITH 668
V D E + M++S DG++LAVGS+D + +Y V++ +Y + G C+ S+ITH
Sbjct: 400 EVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQ---RYKKIGECSKSLSFITH 456
Query: 669 LDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPEG 728
+DWS D+KY+ +N G E L++ +P+G K + ++ + K I W ++TCV G +V G+WP+
Sbjct: 457 IDWSLDSKYLQTNDGAGERLFYRMPSG-KPLTSKEEIKGIPWASWTCVKGPEVSGIWPKY 515
Query: 729 SDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHND 788
++ TDIN++ ++N V+ DDF V LF++PC K A KY HS+HVTNV ++H+
Sbjct: 516 TEVTDINSVDANYNSSVLVSGDDFGLVKLFKFPCLKRGAKFRKYVGHSAHVTNVRWSHDF 575
Query: 789 SHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVSSTESVIQSNTPTPPPSQP- 847
++STGG D S+ QW+ + E V++ L AP + + P
Sbjct: 576 QWVLSTGGADHSVFQWRFIP-------EGVSNGMLETAPQEGGADSYSEESDSDLSDVPE 628
Query: 848 LNETAEEESRISSSPTLLENSLEQTVEPSED 878
L+ E+E++I+ + + L Q + S++
Sbjct: 629 LDSDIEQEAQINYDRQVYKEDLPQLKQQSKE 659
Score = 371 bits (952), Expect = e-102
Identities = 228/631 (36%), Positives = 335/631 (53%), Gaps = 52/631 (8%)
Query: 193 RTELPPEKLKLEWAYGYRGKDCRANVYLLPTGEIVYFIASVVVLFNYEERTQRHYLGHTD 252
R + P + LKL++ +GYRG DCR N++ GE+VY IA+V V++N ++ +QR YLGH D
Sbjct: 669 REKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQRLYLGHDD 728
Query: 253 CVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLD 312
+ L IHP K +ATGQ+ GR HV WD+ TL L ++ G +RGV LD
Sbjct: 729 DILSLTIHPVKDYVATGQV------GRDAAIHV--WDTQTLKCLSLLK-GQHQRGVCALD 779
Query: 313 FSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGK 372
FS + +DD H + WDW+K K A + + + V+ +P + ++T G
Sbjct: 780 FSADGKCLVSVGLDDF--HSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGI 837
Query: 373 SHIFFWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGD-VLTGDSGGVMLIWSKTTVEP 431
HI FW +G T K+G FG K + + C+++ D V +G + G + IW
Sbjct: 838 KHIKFWQQAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIWKDIL--- 894
Query: 432 TPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDH----------- 480
+ K +KAHDG VF + + G + GGKD + LWD
Sbjct: 895 -----------LLKTVKAHDGPVFAMYALDKGFVT--GGKDGIVELWDDMFERCLKTYAI 941
Query: 481 ---DLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTD-E 536
L+ + + + +IRA+ G LVGT IL + + VQGH + E
Sbjct: 942 KRSALSTSSKGLLLEDNPSIRAITLGHG-HILVGTKNGEILEIDKSGPMTLLVQGHMEGE 1000
Query: 537 LWGLATHPFKDLLLTCAQDRQVCLWN-SMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTH 595
+WGLA HP + T + D+ + +W S +HR+ R + + G C F P G +A+G +
Sbjct: 1001 VWGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLN 1060
Query: 596 SGRWFVLDAET-RDLVSIHTDGNEQLSVMRYSID-GTFLAVGSHDNFIYLYVVSENGRKY 653
G + V++A+T D+VS H E +S +++S D G +LAV SHDNF+ +Y V +
Sbjct: 1061 DGSFLVVNADTVEDMVSFH-HRKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTS---- 1115
Query: 654 SRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTY 713
R G C G SSYITH+DW K + NSG E L+++ P G + I S+ + I+W T+
Sbjct: 1116 KRVGICKGASSYITHIDWDSRGKLLQVNSGAREQLFFEAPRGKRHIIRPSEIEKIEWDTW 1175
Query: 714 TCVLGFQVFGVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYS 773
TCVLG G+WP SD TD+NA + + ++A DDF V LF YP A KY
Sbjct: 1176 TCVLGPTCEGIWPAHSDITDVNAASLTKDCSLLATGDDFGFVKLFSYPVKGQHARFKKYV 1235
Query: 774 AHSSHVTNVSFTHNDSHLISTGGKDMSIIQW 804
HS+HVTNV + HNDS L++ GG D +++ W
Sbjct: 1236 GHSAHVTNVRWLHNDSVLLTVGGADTALMIW 1266
Score = 316 bits (809), Expect = 7e-86
Identities = 204/625 (32%), Positives = 319/625 (51%), Gaps = 47/625 (7%)
Query: 199 EKLKLEWAYGYRGKDCRANVYLLPTG-EIVYFIASVVVLFNYEERTQRHYLGHTDCVKCL 257
E+L L+ +GYRG DCR N++ L G +I++ A+ ++ N +Q YL HTD + CL
Sbjct: 1361 EELALDHVFGYRGFDCRNNLHYLNDGADIIFHTAAAGIVQNLSTGSQSFYLEHTDDILCL 1420
Query: 258 AI--HPDKIR--IATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLDF 313
+ HP K R +AT QI P + +WD++T TL ++ +GV ++F
Sbjct: 1421 TVNQHP-KYRNVVATSQIGTT--------PSIHIWDAMTKHTLSMLRC-FHSKGVNYINF 1470
Query: 314 SKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKS 373
S +G L + EH +TVW WQ+ AK A E + VEF P ++ G
Sbjct: 1471 SA--TGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVK 1528
Query: 374 HIFFWTWSGNSLTRKQGIFGKYEKPKFVQCL--AFLGNGDVLTGDSGGVMLIWSKTTVEP 431
H+ FWT +G++L K+G+ G K L AF N TG G + +W
Sbjct: 1529 HMKFWTLAGSALLYKKGVIGSLGAAKMQTMLSVAFGANNLTFTGAINGDVYVW------- 1581
Query: 432 TPGKGPKGVYQISKQIKAHDGSVFTL-CQMRNGMLLTGGGKDRK------IILWDHDLNP 484
K + I KAH G VFT+ +R+G+++TGG K+R + LWD ++
Sbjct: 1582 ------KDHFLIRLVAKAHTGPVFTMYTTLRDGLIVTGG-KERPTKEGGAVKLWDQEMKR 1634
Query: 485 ER--EIEVPDQYGTIRAVAEGKADQFLVGTSRNFILR-GTFNDGFQIEVQGHTD-ELWGL 540
R ++E +R+V GK + LVGT I+ G N I + GH + E+WGL
Sbjct: 1635 CRAFQLETGQLVECVRSVCRGKG-KILVGTKDGEIIEVGEKNAASNILIDGHMEGEIWGL 1693
Query: 541 ATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWF 600
ATHP KDL ++ + D +W+ + +L + CA + P G +VAIG +G +
Sbjct: 1694 ATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHAARCAAYSPDGEMVAIGMKNGEFV 1753
Query: 601 VLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCT 660
+L + + D + +R S D FLAVGS ++ + Y +++ G +R G C
Sbjct: 1754 ILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQ-GTNLNRIGYCK 1812
Query: 661 GHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQ 720
S++ +D+S D KYI ++G Y+ ++P G K + + I W ++T VLG +
Sbjct: 1813 DIPSFVIQMDFSADGKYIQVSTGAYKRQVHEVPLG-KQVTEAVVIEKITWASWTSVLGDE 1871
Query: 721 VFGVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVT 780
V G+WP +D D+N +H I DDF V LF +PC++ A +Y HS+HVT
Sbjct: 1872 VIGIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLFDFPCTEKFAKHKRYFGHSAHVT 1931
Query: 781 NVSFTHNDSHLISTGGKDMSIIQWK 805
N+ F+++D +++STGG D S+ W+
Sbjct: 1932 NIRFSYDDKYVVSTGGDDCSVFVWR 1956
>gi|34485720 echinoderm microtubule associated protein like 5 [Homo
sapiens]
Length = 1977
Score = 365 bits (937), Expect = e-100
Identities = 220/699 (31%), Positives = 360/699 (51%), Gaps = 47/699 (6%)
Query: 197 PPEKLKLEWAYGYRGKDCRANVYLLPTGEIVYFIASVVVLFNYEERTQRHYLGHTDCVKC 256
P L+LEW YGYRG CR N+Y EIVYF+A V V+++ E Q+ Y GH+D +
Sbjct: 7 PSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGHSDDIIS 66
Query: 257 LAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLDFSKA 316
LA+HP+++ +ATGQ+ +P++ +WDS T+ T+ ++ G+ CL F
Sbjct: 67 LALHPERVLVATGQVGK--------EPYICIWDSYTVQTISVLK-DVHTHGIACLAFDL- 116
Query: 317 DSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIF 376
G L + +++ + VWDW++ + + + + + N +++CG HI
Sbjct: 117 -DGQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIK 175
Query: 377 FWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKG 436
FW+ GN+LT K+G+FGK + + CLA + +G G + +W
Sbjct: 176 FWSLCGNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVW------------ 223
Query: 437 PKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPEREIEVPDQYG- 495
KG+ I AH +F++ G GG+D I LWD P I++ +
Sbjct: 224 -KGINLIRTIQGAHAAGIFSMNACEEGFAT--GGRDGCIRLWDLTFKPITVIDLRETDQG 280
Query: 496 ----TIRAVAEGKADQFLVGTSRNFILRGTF---NDGFQIEVQGHTD-ELWGLATHPFKD 547
++R+V + D LVGT + I N F I +QGH + ELW LA HP K
Sbjct: 281 YKGLSVRSVC-WRGDHILVGTQDSEIFEIVVQERNKPFLI-MQGHCEGELWALAVHPTKP 338
Query: 548 LLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETR 607
L +T + DR V +W+ ++H L ++EP CA + G +A+G G + VL
Sbjct: 339 LAVTGSDDRSVRIWSLVDHALIARCNMEEPIRCAAVNADGIHLALGMKDGSFTVLRVRDM 398
Query: 608 DLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYIT 667
V D E + ++YS DGT+LAVG +D+ + +Y V++ +Y + G C G S+IT
Sbjct: 399 TEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVAQ---RYKKVGECLGSLSFIT 455
Query: 668 HLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPE 727
HLDWS D++Y+ +N G+ + L++ +P G K + + + K + W ++TCV G +V G+WP+
Sbjct: 456 HLDWSSDSRYLQTNDGNGKRLFYRMPGG-KEVTSTEEIKGVHWASWTCVSGLEVNGIWPK 514
Query: 728 GSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHN 787
SD DIN++ ++ +V+ ADD+ + LF+YPC + A KY HS+HVTNV ++H+
Sbjct: 515 YSDINDINSVDGNYIGQVLVTADDYGIIKLFRYPCLRKGAKFRKYIGHSAHVTNVRWSHD 574
Query: 788 DSHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVSSTESVIQSNTPTPPPSQP 847
+IS GG D S+ QWK + + L +A S S+ P
Sbjct: 575 YQWVISIGGADHSVFQWKFIPERKLKDAVHIAPQESLADSHSDESDSDLSDVP------E 628
Query: 848 LNETAEEESRISSSPTLLENSLEQTVEPSEDHSEEESEE 886
L+ E+E++++ + + L Q E ++ + + +
Sbjct: 629 LDSEIEQETQLTYRRQVYKEDLPQLKEQCKEKQKSATSK 667
Score = 350 bits (898), Expect = 3e-96
Identities = 216/631 (34%), Positives = 333/631 (52%), Gaps = 52/631 (8%)
Query: 193 RTELPPEKLKLEWAYGYRGKDCRANVYLLPTGEIVYFIASVVVLFNYEERTQRHYLGHTD 252
R P ++L + +GYRG DCR+N++ GEIVY +A+V V++N ++ TQR YLGH D
Sbjct: 669 RERAPGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQRFYLGHDD 728
Query: 253 CVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLD 312
+ CL IHP K +ATGQ+ GR P + +WD+ T+ L I+ G + GV +D
Sbjct: 729 DILCLTIHPLKDYVATGQV------GR--DPSIHIWDTETIKPLSILK-GHHQYGVSAVD 779
Query: 313 FSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGK 372
FS + IDDS H + +WDW+K K + + + + + V+ +P + +IT G
Sbjct: 780 FSADGKRLASVGIDDS--HTVVLWDWKKGEKLSIARGSKDKIFVVKMNPYVPDKLITAGI 837
Query: 373 SHIFFWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDV-LTGDSGGVMLIWSKTTVEP 431
H+ FW +G L ++G G K + C + ++ +G S G + IW
Sbjct: 838 KHMKFWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIW------- 890
Query: 432 TPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNP------- 484
+ ++ + K +KAHDG VF++ + G + GGKD + LWD
Sbjct: 891 ------RDIFLV-KTVKAHDGPVFSMHALEKGFVT--GGKDGIVALWDDSFERCLKTYAI 941
Query: 485 EREIEVPDQYG-------TIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTD-E 536
+R P G +IRA++ G LVGT IL + + VQGH + E
Sbjct: 942 KRAALAPGSKGLLLEDNPSIRAISLGHG-HILVGTKNGEILEVDKSGPITLLVQGHMEGE 1000
Query: 537 LWGLATHPFKDLLLTCAQDRQVCLWN-SMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTH 595
+WGLATHP+ + T + D+ + +W+ S H + R + + G C F P G +A+G +
Sbjct: 1001 VWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLN 1060
Query: 596 SGRWFVLDAET-RDLVSIHTDGNEQLSVMRYSI-DGTFLAVGSHDNFIYLYVVSENGRKY 653
G + + +A+T DLVS H + +S +R+S G +LAV SHD+FI +Y V +
Sbjct: 1061 DGSFLMANADTLEDLVSFH-HRKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMSS---- 1115
Query: 654 SRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTY 713
R G C G +SYITH+DW K + N+G E L+++ P G K + + I W ++
Sbjct: 1116 KRVGICKGATSYITHIDWDIRGKLLQVNTGAKEQLFFEAPRGKKQTIPSVEVEKIAWASW 1175
Query: 714 TCVLGFQVFGVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYS 773
T VLG G+WP + TD+ A + ++ V+A DD V LF+YP +Y
Sbjct: 1176 TSVLGLCCEGIWPVIGEVTDVTASCLTSDKMVLATGDDLGFVKLFRYPTKGKFGKFKRYV 1235
Query: 774 AHSSHVTNVSFTHNDSHLISTGGKDMSIIQW 804
AHS+HVTNV +T++DS L++ GG DMS++ W
Sbjct: 1236 AHSTHVTNVRWTYDDSMLVTLGGTDMSLMVW 1266
Score = 311 bits (796), Expect = 2e-84
Identities = 203/628 (32%), Positives = 312/628 (49%), Gaps = 38/628 (6%)
Query: 197 PPEKLKLEWAYGYRGKDCRANVYLLPTGE-IVYFIASVVVLFNYEERTQRHYLGHTDCVK 255
P E L LE +GYRG+DCR NV+ L G+ I+Y ASV +L N +Q Y H D +
Sbjct: 1367 PIEDLVLELIFGYRGRDCRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDIL 1426
Query: 256 CLAI--HPDKIRI-ATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLD 312
CL + HP I I ATGQ+ G D P + +WD++ TL I+ +GV +
Sbjct: 1427 CLTVNQHPKFINIVATGQV-GDSADMSATAPSIHIWDAMNKQTLSILRC-YHSKGVCSVS 1484
Query: 313 FSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGK 372
FS +G L + EH +T+W WQ+ AK A N+ + EF P ++ G
Sbjct: 1485 FSA--TGKLLLSVGLDPEHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGV 1542
Query: 373 SHIFFWTWSGNSLTRKQGIFGKYEKPKF--VQCLAFLGNGDVLTGDSGGVMLIWSKTTVE 430
H+ FWT +G +L K+G+ E + + +AF N TG G + +W
Sbjct: 1543 KHVKFWTLAGRALLSKKGLLSTLEDARMQTMLAIAFGANNLTFTGTISGDVCVW------ 1596
Query: 431 PTPGKGPKGVYQISKQIKAHDGSVFTL-CQMRNGMLLTGGGKDRK------IILWDHDLN 483
K +AH+G VF + +R+G+++TGG K+R + LWD +L
Sbjct: 1597 -------KDHILCRIVARAHNGPVFAMYTTLRDGLIVTGG-KERPSKEGGAVKLWDQELR 1648
Query: 484 PEREIEVPDQYGT--IRAVAEGKADQFLVGTSRNFILR-GTFNDGFQIEVQGHTD-ELWG 539
R + T +R+V GK + LVGT I+ G N I V GH D +WG
Sbjct: 1649 RCRAFRLETGQATDCVRSVCRGKG-KILVGTRNAEIIEVGEKNAACNILVNGHVDGPIWG 1707
Query: 540 LATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRW 599
LATHP +D L+ A+D V LW+ + ++ + + P G +VAIG +G +
Sbjct: 1708 LATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAARTVCYSPEGDMVAIGMKNGEF 1767
Query: 600 FVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRC 659
+L + + D + +R+S D +LAVGS +N + Y ++ G +R C
Sbjct: 1768 IILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTL-GPTLNRISYC 1826
Query: 660 TGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGF 719
S++ +D+S D+ Y+ +SG Y+ +++P+G K + + + I W T+T +LG
Sbjct: 1827 KDIPSFVIQMDFSADSSYLQVSSGCYKRHVYEVPSG-KHLMDHAAIDRITWATWTSILGD 1885
Query: 720 QVFGVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHV 779
+V G+W ++ D+N SH+ + DDF V LF +PC + A ++ HS HV
Sbjct: 1886 EVLGIWSRHAEKADVNCACVSHSGISLVTGDDFGMVKLFDFPCPEKFAKHKRFLGHSPHV 1945
Query: 780 TNVSFTHNDSHLISTGGKDMSIIQWKLV 807
TN+ FT D H++S GG D S+ WK V
Sbjct: 1946 TNIRFTSGDRHVVSAGGDDCSLFVWKCV 1973
>gi|31377846 WD repeat domain 52 [Homo sapiens]
Length = 982
Score = 87.0 bits (214), Expect = 7e-17
Identities = 123/578 (21%), Positives = 220/578 (38%), Gaps = 108/578 (18%)
Query: 194 TELPPEKLKLEWAYGYRGKDCR--ANVYLLPTGEIVYFIASVVVLFNYEERTQRHYLGHT 251
+ +P + L L ++GY DCR AN+ LL +Y + ++ N + + Q + +
Sbjct: 126 SNIPLDLLTLVHSFGY---DCRKRANLQLLDDSIAIYIAGNQLIFLNLKTKEQIYLRSSS 182
Query: 252 -DCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGC 310
+ + + +HP K + P + +++ +L +++ GT E+G
Sbjct: 183 GEGIGVIGVHPHKTYFTVAEKGSF--------PDIIIYEYPSLRPYRVLRDGT-EKGYAY 233
Query: 311 LDFSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITC 370
+DF+ SG L + + ++ LT+W+W+++ K ++ V V F+P + T
Sbjct: 234 VDFNY--SGNLLASVGSNPDYTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDKEEQLTTS 291
Query: 371 GKSHIFFW----TWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIW-- 424
G HI FW T++G L G FGK ++ L +G VL+G G ML+W
Sbjct: 292 GSGHIKFWEMAFTFTGLKLQGSLGRFGKTITTD-IEGYMELPDGKVLSGSEWGNMLLWEG 350
Query: 425 SKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNP 484
VE G QI ++G V T+ G D + +WD +
Sbjct: 351 GLIKVELCRGTSKSCHNGPINQIMLYEGEVITV------------GSDGYVRIWDFETID 398
Query: 485 EREIEVPDQYGTIRAVAEGKADQ--------FLVGTSRNFILRGTFNDGF---------- 526
++ I + E + D+ + T NF L N
Sbjct: 399 TADVIDETGLLEIEPINELQVDKNVNLFSMIKMNETGNNFWLAQDANGAIWKLDLSFSNI 458
Query: 527 ----QIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWN--------SMEHRLEWTRLV 574
+ H+ + +A P L+ T A D V +++ M+ + T LV
Sbjct: 459 TQDPECLFSFHSGAIEAVAVSPLTYLMATTALDCSVRIYDFASKTPLAQMKFKQGGTALV 518
Query: 575 DEPGHCADFHPSGTVV----------------AIGTHSGRWFVLDAETRDLVSIHTDGNE 618
P +F + +V + +GR +LDA+ + L +
Sbjct: 519 WVP-RMVNFTGAQIIVGFEDGVVRILELYDPKGLTIFAGRKKILDADIQ-LKQVFKPHTA 576
Query: 619 QLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSP----- 673
++ + Y DG LA GS D ++ + V R Y G + L WSP
Sbjct: 577 CVTALAYERDGEILATGSKDQTVFFFEVE---RDYKPIGYINTPGP-VCQLMWSPMSHPE 632
Query: 674 -------DNKYIM--------SNSGDYEILYWDIPNGC 696
+N YI+ D++++ ++I + C
Sbjct: 633 STLLIICENGYILEAPLPTIKQEEDDHDVVSYEIKDMC 670
>gi|145279222 WD repeat domain 66 [Homo sapiens]
Length = 1149
Score = 82.0 bits (201), Expect = 2e-15
Identities = 141/709 (19%), Positives = 262/709 (36%), Gaps = 131/709 (18%)
Query: 197 PPEKLKLEWAYGYRGKDCRANVYLLPTGE---IVYFIASVVVLFNYEERTQRHYLGHTDC 253
P L + W++G+ VY + ++Y A +++N Q H GH +
Sbjct: 245 PVYPLTMTWSFGWNSS---LPVYYIREERQRVLLYVCAHTAIIYNVFRNNQYHLQGHANI 301
Query: 254 VKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLDF 313
+ CL + D+ IAT DK L V +WDS T + I + G G +
Sbjct: 302 ISCLCVSEDRRWIAT-----ADKGPDCL---VIIWDSFTGIPVHTI-FDSCPEGNGIMAM 352
Query: 314 SKADSGVHLCVIDDSNEHMLTVWDW----QKKAKGAEIKTTNEVVLAVEFHPTDANTIIT 369
+ +L I D+ + +W W + A E+ T V V F+PT+ +++
Sbjct: 353 AMTHDAKYLATISDAEVQKVCIWKWTLAVETPACTLELPTEYGVQNYVTFNPTNNKELVS 412
Query: 370 CGKSHIFFWTW---------SGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGV 420
K+ ++ W S LT K F K KF Q + L +L+ G
Sbjct: 413 NSKTRAIYYAWYEERDTLAHSAPLLTEK--TFNKL-VGKFSQSIFHLNLTQILSATMEGK 469
Query: 421 MLIW-------SKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDR 473
+++W S +T P P + + K+ T+ + ++TG K
Sbjct: 470 LVVWDIHRPPSSASTFLGFPYIKPCKLVHLQKE-------GITVLTTIDSYIVTGDIKG- 521
Query: 474 KIILWDHDLNPEREIEVPDQY-----GTIRAVAEGKAD---------------------- 506
I +DH L+ + + Y G IR ++ K
Sbjct: 522 NIKFYDHTLS------IVNWYSHLKLGAIRTLSFSKTPATPPTEKSNYPPDCTLKGDLFV 575
Query: 507 --QFLVGTSRNFILRGTFNDGFQIE--VQGHTDELWGLATHPFKDLLLTCAQDRQVCLWN 562
F++GTS + T DG ++E D + ++ HP++ L+ + + +WN
Sbjct: 576 LRNFIIGTSDAAVYHLT-TDGTKLEKLFVEPKDAICAISCHPYQPLIAIGSICGMIKVWN 634
Query: 563 SMEHRLEWTRLVDE--PGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQL 620
+ ++R+ ++ ++P G ++ G G ++LDA + + S +
Sbjct: 635 YENKQYLFSRVFEKGLGVQSLTYNPEGALLGAGFTEGTVYILDAMSLENESPEPFKYSRT 694
Query: 621 SV--MRYSIDGTFLAVG--SHDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDW----S 672
SV + +S D ++A S +Y+ VV R + R H I L +
Sbjct: 695 SVTHISFSHDSQYMATADRSFTVAVYMLVVRNGQRVWEYLARLRSHRKSIRSLLFGVYLD 754
Query: 673 PDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTY-TCVL-------------- 717
+ ++S D ++ +D+ K D D Y TC++
Sbjct: 755 SNEPRLLSLGTDRLLIEYDLLRSYKDHLEVLDIHHTDQGCYPTCMVWYPPLTRELFLLIC 814
Query: 718 --GFQV------------------FGVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHL 757
G++V +G E + + ++ R ++ + D KV L
Sbjct: 815 NSGYKVKLFNATTKMCRKTLLGPAYGSPIEQTQVLPVRSMAELQKRYLVFINRD--KVGL 872
Query: 758 FQYPCSKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTGGKDMSIIQWKL 806
P + H + V ++ +++ + + GG D S++QWK+
Sbjct: 873 QILPVDGNPHKTSAIVCHPNGVAGMAVSYDGCYAFTAGGHDRSVVQWKI 921
>gi|94400919 WD repeat domain 90 [Homo sapiens]
Length = 1748
Score = 73.2 bits (178), Expect = 1e-12
Identities = 130/615 (21%), Positives = 223/615 (36%), Gaps = 76/615 (12%)
Query: 58 HVASVKKSVSSKGQPSPRAVIPMSCITNGSG--------ANRKPSHTSAVSIAGKETLSS 109
HV +S+ +P ++ P + G G A+ KP S + + ++
Sbjct: 221 HVRFPSESLKVPSKPIEKSCSPPEAVLLGPGPQPLPCPVASSKPVRFSVSPVVQTPSPTA 280
Query: 110 AAKSIKRPSPAEKSHNSWENSDDSRNK---LSKIPSTPKLIPKVTKTADKHKDVIINQEG 166
+ ++ P P + S E SD S + +L TA V+ ++
Sbjct: 281 SGRAALAPRPFPEVSLSQERSDASNADGPGFHSLEPWAQLEASDIHTAAAGTHVLTHESA 340
Query: 167 EYIKMFMRGRPITMFIPSDVDNYDDIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGEI 226
E +P V LP L+L+ G+ G R ++ +
Sbjct: 341 E--------------VP--VARTGSCEGFLPDPVLRLKGVIGFGGHGTRQALWTPDGAAV 384
Query: 227 VYFIASVVVLFNYEERTQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVR 286
VY +V+V+ + QR +LGHTD V LA+ +A+ Q +R
Sbjct: 385 VYPCHAVIVVLLVDTGEQRFFLGHTDKVSALALDGSSSLLASAQARAPSV--------MR 436
Query: 287 VWDSVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCVI--DDSNEHMLTVWDWQKKAKG 344
+WD T + + L V C S +DSG LC + D M+ W + G
Sbjct: 437 LWD---FQTGRCLCLFRSPMHVVC-SLSFSDSGALLCGVGKDHHGRTMVVAWGTGQVGLG 492
Query: 345 AEIKT-----TNEVVLAVEFHPTDANTIITCGKSHIFFWTWSGNSLTRKQGIFGKYEKPK 399
E+ T+ V A D + +CG+ + W G L G++ +
Sbjct: 493 GEVVVLAKAHTDFDVQAFRVTFFDETRMASCGQGSVRLWRLRGGVLRSCPVDLGEHHALQ 552
Query: 400 FVQCLAFLGNGDVLTGDSGGVMLIWSKT---------------TVEPTPGKGPKGVYQIS 444
F LAF D S ++ + S++ P + P G +
Sbjct: 553 FTD-LAFKQARDGCPEPSAAMLFVCSRSGHILEIDCQRMVVRHARRLLPTRTPGGPHPQK 611
Query: 445 KQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNP---EREIEVPDQYGTIRAVA 501
+ + G + + M G +D + LW D + E E E P ++
Sbjct: 612 QTFSSGPGIAISSLSVSPAMCAV-GSEDGFLRLWPLDFSSVLLEAEHEGP--VSSVCVSP 668
Query: 502 EGKADQFLVGTSRNFI-LRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCL 560
+G + L TS + T + + + + HT + LA + L T +QDR V +
Sbjct: 669 DGL--RVLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRRGQLATVSQDRTVRI 726
Query: 561 WN--SMEHRLEWTRLVDEPGHCA-DFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGN 617
W+ +++ ++T D P CA FHP+ G SG E +++ HT
Sbjct: 727 WDLATLQQLYDFTSSEDAP--CAVTFHPTRPTFFCGFSSGAVRSFSLEAAEVLVEHTCHR 784
Query: 618 EQLSVMRYSIDGTFL 632
++ + + DG L
Sbjct: 785 GAVTGLTATPDGRLL 799
Score = 43.1 bits (100), Expect = 0.001
Identities = 80/381 (20%), Positives = 140/381 (36%), Gaps = 46/381 (12%)
Query: 201 LKLEWAYGYRGKDCRANVYLLP-TGEIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAI 259
L+L+ GY G RAN+ P TG Y +VV+ + Q+H+ GH+ + LA+
Sbjct: 1108 LRLKAVVGYSGNG-RANMVWRPDTGFFAYTCGRLVVVEDLHSGAQQHWSGHSAEISTLAL 1166
Query: 260 HPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLDFSKADSG 319
+A+ + +RVWD V+ Q + F L + +
Sbjct: 1167 SHSAQVLASAS----GRSSTTAHCQIRVWD-VSGGLCQHL---IFPHSTTVLALAFSPDD 1218
Query: 320 VHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTN--EVVLAVEFHPTDANTIITCGKSHIFF 377
L + D + L +W A + +T E V V F+P DA + G+ + F
Sbjct: 1219 RLLVTLGDHDGRTLALWG---TATYDLVSSTRLPEPVHGVAFNPWDAGELTCVGQGTVTF 1275
Query: 378 WTWSGN----SLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTP 433
W SL ++ + + L + + G S G + +W
Sbjct: 1276 WLLQQRGADISLQVRREPVPEAVGAGELTSLCYGAPPLLYCGTSSGQVCVWDTRA----- 1330
Query: 434 GKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPE-------- 485
G +S + A DG + L + +G L G ++ LW E
Sbjct: 1331 -----GRCFLSWE--ADDGGIGLL--LFSGSRLVSGSSTGRLRLWAVGAVSELRCKGSGA 1381
Query: 486 ----REIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIE-VQGHTDELWGL 540
E E+ + A + D +VGT+ + ++ +G + GH ++ +
Sbjct: 1382 SSVFMEHELVLDGAVVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSKVNEV 1441
Query: 541 ATHPFKDLLLTCAQDRQVCLW 561
P + TC++D V +W
Sbjct: 1442 VFSPGESHCATCSEDGSVRVW 1462
>gi|22749037 WD repeat domain 65 [Homo sapiens]
Length = 698
Score = 70.1 bits (170), Expect = 9e-12
Identities = 113/534 (21%), Positives = 199/534 (37%), Gaps = 94/534 (17%)
Query: 330 EHMLTVWDWQKKAKGA--EIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWTWSGNSLTR 387
E L W W+K+ A I T N V V F P D + G ++ +L
Sbjct: 130 ESNLVYWLWEKQKVMAIVRIDTQNNPVYQVSFSPQDNTQVCVTGNGMFKLLRFAEGTL-- 187
Query: 388 KQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWS-----KTTV---EPTPGKGPKG 439
KQ F + E ++ + V+ D+G + L S +T++ EPT G
Sbjct: 188 KQTSFQRGEPQNYLAHTWVADDKIVVGTDTGKLFLFESGDQRWETSIMVKEPTNGSKSLD 247
Query: 440 VYQISKQI-------------------KAHDG----SVFTLCQMRNGMLLTGGGKDRKII 476
V Q S+ + +H VF + G + G +++
Sbjct: 248 VIQESESLIEFPPVSSPLPSYEQMVAASSHSQMSMPQVFAIAAYSKGFACSAG--PGRVL 305
Query: 477 LWDH----DLNPE-REIEVP-----------DQYGTIRAVAEGKADQFLVGTSRNFILRG 520
L++ D E REI +P D+ + + + TS+N +
Sbjct: 306 LFEKMEEKDFYRESREIRIPVDPQSNDPSQSDKQDVLCLCFSPSEETLVASTSKNQLYSI 365
Query: 521 TFN---------DGFQIEVQG-HTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEW 570
T + F+ + H+ + GLAT K L+ TC+ DR + LWN + LE
Sbjct: 366 TMSLTEISKGEPAHFEYLMYPLHSAPITGLATCIRKPLIATCSLDRSIRLWNYETNTLEL 425
Query: 571 TRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGT 630
+ E + HPSG + +G + + +++ D+ S +S +G
Sbjct: 426 FKEYQEEAYSISLHPSGHFIVVG-FADKLRLMNLLIDDIRSFKEYSVRGCGECSFS-NGG 483
Query: 631 FLAVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYW 690
L + N I++Y + GH+ I + W+ D+ ++S D + W
Sbjct: 484 HLFAAVNGNVIHVYTTT----SLENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEW 539
Query: 691 DIPNGCKLIRNRSDCKDIDWTTYTCV-LGFQVFGVWPEGSDGT----------------- 732
++ G + ++C + +Y CV + ++ GSD T
Sbjct: 540 NLSTG----KRETECV-LKSCSYNCVTVSPDAKIIFAVGSDHTLKEIADSLILREISAFD 594
Query: 733 -DINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFT 785
A+V SH+ +++ V + +YP K ++Y AH+ +T VS T
Sbjct: 595 VTYTAIVISHSGRMMFVGTSVGTIRAMKYPLPLQK-EFNEYQAHAGPITKVSRT 647
>gi|190684671 mitogen-activated protein kinase binding protein 1
isoform a [Homo sapiens]
Length = 1508
Score = 67.4 bits (163), Expect = 6e-11
Identities = 60/211 (28%), Positives = 92/211 (43%), Gaps = 20/211 (9%)
Query: 169 IKMFMRGRPITMFIPSDVDNYDDIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGEIVY 228
IK +R I + + +D+ +++ EK+ G RG C +G + Y
Sbjct: 12 IKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR-----SGLVAY 66
Query: 229 FIASVVVLFNYEERTQRHYLGHT-DCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRV 287
VVVLFN + Q H L + + LA PD + TG+ + P VRV
Sbjct: 67 PAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHM--------PAVRV 118
Query: 288 WDSVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEI 347
WD S Q+ L + GV C+ FS S ++ + ++ ++ VW W+K A
Sbjct: 119 WDVAEHS--QVAELQEHKYGVACVAFS--PSAKYIVSVGYQHDMIVNVWAWKKNIVVASN 174
Query: 348 KTTNEVVLAVEFHPTDANTIITCGKSHIFFW 378
K ++ V AV F D + +T G HI FW
Sbjct: 175 KVSSRVT-AVSF-SEDCSYFVTAGNRHIKFW 203
Score = 40.8 bits (94), Expect = 0.006
Identities = 72/328 (21%), Positives = 134/328 (40%), Gaps = 46/328 (14%)
Query: 585 PSGTVVAIGTHSGRWFVLDAET-RDLVSIHTDGNEQLSVMRYSIDGT---FLAVGSHDNF 640
P+G +A G G V + ++ +++ + +E L + YS T LA S D
Sbjct: 483 PNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILC-LEYSKPDTGLKLLASASRDRL 541
Query: 641 IYLYVVSENGRKYSRYGRCTGHSSYITHLDWSP-DNKYIMSNSGDYEILYWDIP----NG 695
I+ V + GR+YS HSS IT + ++ D + M + G + +Y+ +G
Sbjct: 542 IH---VLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDG 598
Query: 696 CKLIRN-----RSDCKDID----WTTYTCV----LGFQVFGVWP-------EGSDGTDIN 735
+ R ++ D+D W YT + ++F + +GS G D
Sbjct: 599 VQFTRTHHVVRKTTLYDMDVEPSWK-YTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGT 657
Query: 736 ALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTG 795
+ + I +A +L + S + + + HS VT + F+++ HLIS
Sbjct: 658 LIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFG-HSEIVTGMKFSNDCKHLISVS 716
Query: 796 GKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVSSTESVIQSNTPTPPPSQPLNETAEEE 855
G D I W+L ++++ + +A+ + + + P+ P +
Sbjct: 717 G-DSCIFVWRLSSEMTISMRQRLAE-------LRQRQRGGKQQGPSSPQRASGPNRHQAP 768
Query: 856 SRISSSPTLLENSLEQTVEPSEDHSEEE 883
S +S P L S + E ++ +EEE
Sbjct: 769 SMLSPGPAL---SSDSDKEGEDEGTEEE 793
Score = 38.1 bits (87), Expect = 0.038
Identities = 82/393 (20%), Positives = 150/393 (38%), Gaps = 57/393 (14%)
Query: 329 NEHMLTVWDWQKKAKGAEIKTT---NEVVLAVEFHPTDANTIITCGKSHIFFWTWSGNSL 385
N+H + VWD + K ++ + + V +VE +P ++ C F S N++
Sbjct: 358 NDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSDNTI 417
Query: 386 ----TRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTV---EPTPGKGPK 438
T G+ G + ++L+ D ++ + T PG
Sbjct: 418 RLWNTESSGVHGSTL------------HRNILSSDLIKIIYVDGNTQALLDTELPGGDKA 465
Query: 439 GVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPERE-IEVPDQYGTI 497
+ ++ + ++C NG L G DR L H+L E ++V I
Sbjct: 466 DASLLDPRV-----GIRSVCVSPNGQHLASG--DRMGTLRVHELQSLSEMLKVEAHDSEI 518
Query: 498 RAVAEGKAD---QFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQ 554
+ K D + L SR+ ++ + G + +Q DE T + A
Sbjct: 519 LCLEYSKPDTGLKLLASASRDRLIH-VLDAGREYSLQQTLDEHSSSIT-----AVKFAAS 572
Query: 555 DRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGT-------HSGRWFVLDAETR 607
D QV + + + + R + G F + VV T S ++ + + R
Sbjct: 573 DGQVRMISCGADKSIYFRTAQKSGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDR 632
Query: 608 DLVSIHTDGNEQLSVMRYSI--DGTFLAVGSHDNFIYLYVVSENGRKYSRY----GRCT- 660
++ + +Q + + S DGT + V + + IY+ S + + S + G C
Sbjct: 633 NIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYI-ATSCSDKNLSIFDFSSGECVA 691
Query: 661 ---GHSSYITHLDWSPDNKYIMSNSGDYEILYW 690
GHS +T + +S D K+++S SGD I W
Sbjct: 692 TMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 724
>gi|190684677 mitogen-activated protein kinase binding protein 1
isoform b [Homo sapiens]
Length = 1514
Score = 67.4 bits (163), Expect = 6e-11
Identities = 60/211 (28%), Positives = 92/211 (43%), Gaps = 20/211 (9%)
Query: 169 IKMFMRGRPITMFIPSDVDNYDDIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGEIVY 228
IK +R I + + +D+ +++ EK+ G RG C +G + Y
Sbjct: 12 IKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR-----SGLVAY 66
Query: 229 FIASVVVLFNYEERTQRHYLGHT-DCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRV 287
VVVLFN + Q H L + + LA PD + TG+ + P VRV
Sbjct: 67 PAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHM--------PAVRV 118
Query: 288 WDSVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEI 347
WD S Q+ L + GV C+ FS S ++ + ++ ++ VW W+K A
Sbjct: 119 WDVAEHS--QVAELQEHKYGVACVAFS--PSAKYIVSVGYQHDMIVNVWAWKKNIVVASN 174
Query: 348 KTTNEVVLAVEFHPTDANTIITCGKSHIFFW 378
K ++ V AV F D + +T G HI FW
Sbjct: 175 KVSSRVT-AVSF-SEDCSYFVTAGNRHIKFW 203
Score = 40.8 bits (94), Expect = 0.006
Identities = 72/328 (21%), Positives = 134/328 (40%), Gaps = 46/328 (14%)
Query: 585 PSGTVVAIGTHSGRWFVLDAET-RDLVSIHTDGNEQLSVMRYSIDGT---FLAVGSHDNF 640
P+G +A G G V + ++ +++ + +E L + YS T LA S D
Sbjct: 489 PNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILC-LEYSKPDTGLKLLASASRDRL 547
Query: 641 IYLYVVSENGRKYSRYGRCTGHSSYITHLDWSP-DNKYIMSNSGDYEILYWDIP----NG 695
I+ V + GR+YS HSS IT + ++ D + M + G + +Y+ +G
Sbjct: 548 IH---VLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDG 604
Query: 696 CKLIRN-----RSDCKDID----WTTYTCV----LGFQVFGVWP-------EGSDGTDIN 735
+ R ++ D+D W YT + ++F + +GS G D
Sbjct: 605 VQFTRTHHVVRKTTLYDMDVEPSWK-YTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGT 663
Query: 736 ALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTG 795
+ + I +A +L + S + + + HS VT + F+++ HLIS
Sbjct: 664 LIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFG-HSEIVTGMKFSNDCKHLISVS 722
Query: 796 GKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVSSTESVIQSNTPTPPPSQPLNETAEEE 855
G D I W+L ++++ + +A+ + + + P+ P +
Sbjct: 723 G-DSCIFVWRLSSEMTISMRQRLAE-------LRQRQRGGKQQGPSSPQRASGPNRHQAP 774
Query: 856 SRISSSPTLLENSLEQTVEPSEDHSEEE 883
S +S P L S + E ++ +EEE
Sbjct: 775 SMLSPGPAL---SSDSDKEGEDEGTEEE 799
Score = 38.1 bits (87), Expect = 0.038
Identities = 82/393 (20%), Positives = 150/393 (38%), Gaps = 57/393 (14%)
Query: 329 NEHMLTVWDWQKKAKGAEIKTT---NEVVLAVEFHPTDANTIITCGKSHIFFWTWSGNSL 385
N+H + VWD + K ++ + + V +VE +P ++ C F S N++
Sbjct: 364 NDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSDNTI 423
Query: 386 ----TRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTV---EPTPGKGPK 438
T G+ G + ++L+ D ++ + T PG
Sbjct: 424 RLWNTESSGVHGSTL------------HRNILSSDLIKIIYVDGNTQALLDTELPGGDKA 471
Query: 439 GVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPERE-IEVPDQYGTI 497
+ ++ + ++C NG L G DR L H+L E ++V I
Sbjct: 472 DASLLDPRV-----GIRSVCVSPNGQHLASG--DRMGTLRVHELQSLSEMLKVEAHDSEI 524
Query: 498 RAVAEGKAD---QFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQ 554
+ K D + L SR+ ++ + G + +Q DE T + A
Sbjct: 525 LCLEYSKPDTGLKLLASASRDRLIH-VLDAGREYSLQQTLDEHSSSIT-----AVKFAAS 578
Query: 555 DRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGT-------HSGRWFVLDAETR 607
D QV + + + + R + G F + VV T S ++ + + R
Sbjct: 579 DGQVRMISCGADKSIYFRTAQKSGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDR 638
Query: 608 DLVSIHTDGNEQLSVMRYSI--DGTFLAVGSHDNFIYLYVVSENGRKYSRY----GRCT- 660
++ + +Q + + S DGT + V + + IY+ S + + S + G C
Sbjct: 639 NIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYI-ATSCSDKNLSIFDFSSGECVA 697
Query: 661 ---GHSSYITHLDWSPDNKYIMSNSGDYEILYW 690
GHS +T + +S D K+++S SGD I W
Sbjct: 698 TMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 730
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 61.6 bits (148), Expect = 3e-09
Identities = 45/167 (26%), Positives = 73/167 (43%), Gaps = 9/167 (5%)
Query: 531 QGHTDELWGLATHPFKDLLLTCAQDRQVCLWN---SMEHRLEWTRLVDEPGHCADFHPSG 587
QGH +W L P+ + + DR LW+ + R+ L D C FHP+
Sbjct: 381 QGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVD--CVKFHPNS 438
Query: 588 TVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVS 647
+A G+ + A+ + V + T + + +S +G +LA D + L+ ++
Sbjct: 439 NYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLA 498
Query: 648 ENGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPN 694
+ Y GH+ IT L +SPD+ I S S D + WDI N
Sbjct: 499 SG----TLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541
Score = 47.8 bits (112), Expect = 5e-05
Identities = 42/190 (22%), Positives = 80/190 (42%), Gaps = 16/190 (8%)
Query: 523 NDGFQIEV-QGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHC- 580
N G ++++ +GH ++ LL+C++D + W+ +T V GH
Sbjct: 330 NAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGS----FTNTVLYQGHAY 385
Query: 581 ----ADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGS 636
D P A G+H + + + I+ + +++ + +LA GS
Sbjct: 386 PVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGS 445
Query: 637 HDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGC 696
D + L+ ++ G + TGH + L +SP+ KY+ S D + WD+ +G
Sbjct: 446 TDKTVRLWS-AQQGNSVRLF---TGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGT 501
Query: 697 --KLIRNRSD 704
K +R +D
Sbjct: 502 LYKELRGHTD 511
Score = 34.7 bits (78), Expect = 0.42
Identities = 34/163 (20%), Positives = 54/163 (33%), Gaps = 54/163 (33%)
Query: 401 VQCLAFLGNGDVL-TGDSGGVMLIWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQ 459
V C+ F N + L TG + + +WS + H G V +L
Sbjct: 429 VDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSV------------RLFTGHRGPVLSLAF 476
Query: 460 MRNGMLLTGGGKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILR 519
NG L G+D+++ LWD +
Sbjct: 477 SPNGKYLASAGEDQRLKLWD-------------------------------------LAS 499
Query: 520 GTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWN 562
GT E++GHTD + L P L+ + + D V +W+
Sbjct: 500 GTLYK----ELRGHTDNITSLTFSPDSGLIASASMDNSVRVWD 538
Score = 30.4 bits (67), Expect = 7.9
Identities = 28/117 (23%), Positives = 50/117 (42%), Gaps = 16/117 (13%)
Query: 245 RHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTF 304
R Y GH V C+ HP+ +ATG DK VR+W + +++++ T
Sbjct: 420 RIYAGHLADVDCVKFHPNSNYLATG---STDKT-------VRLWSAQQGNSVRLF---TG 466
Query: 305 ERGVGCLDFSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHP 361
RG L + + +G +L + L +WD E++ + + ++ F P
Sbjct: 467 HRG-PVLSLAFSPNGKYLA--SAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSP 520
>gi|145580608 WD repeat domain 62 isoform 1 [Homo sapiens]
Length = 1523
Score = 60.8 bits (146), Expect = 5e-09
Identities = 46/157 (29%), Positives = 75/157 (47%), Gaps = 15/157 (9%)
Query: 223 TGEIVYFIASVVVLFNYEERTQRHYLGHT-DCVKCLAIHPDKIRIATGQIAGVDKDGRPL 281
TG + Y VVV+ + +E Q+H + LA PD I TG+ +G
Sbjct: 82 TGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGE------NGH-- 133
Query: 282 QPHVRVWDSVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCVIDDSNEHMLTVWDWQKK 341
+P VR+WD + Q+ + + GV C+ FS + H+ + ++ +L VWDW+K
Sbjct: 134 RPAVRIWDVEEKN--QVAEMLGHKYGVACVAFSP--NMKHIVSMGYQHDMVLNVWDWKKD 189
Query: 342 AKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFW 378
A K + V+ A+ F D++ +T G H+ FW
Sbjct: 190 IVVASNKVSCRVI-ALSF-SEDSSYFVTVGNRHVRFW 224
Score = 34.3 bits (77), Expect = 0.55
Identities = 45/214 (21%), Positives = 91/214 (42%), Gaps = 15/214 (7%)
Query: 446 QIKAHDGSVFTL--CQMRNGM-LLTGGGKDRKIILWDHDLNPEREIEVPDQYGTIRAVA- 501
+++AHD V L + G+ LL +DR I + + + N E + D +I A+
Sbjct: 529 KVEAHDAEVLCLEYSKPETGLTLLASASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKF 588
Query: 502 EGKADQFLV--GTSRNFILRGTF--NDGFQIEVQGHTDE---LWGLATHPFKDLLLTCAQ 554
G D ++ G ++ R +DG H E L+ + + + Q
Sbjct: 589 AGNRDIQMISCGADKSIYFRSAQQGSDGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQ 648
Query: 555 DRQVCLWNSMEHRLE--WTRLVDEPGHCADFH--PSGTVVAIGTHSGRWFVLDAETRDLV 610
DR V ++N++ + + + + G H PSGT +A V+D + + +
Sbjct: 649 DRNVRVYNTVNGKQKKCYKGSQGDEGSLLKVHVDPSGTFLATSCSDKSISVIDFYSGECI 708
Query: 611 SIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLY 644
+ +E ++ M+++ D L S D+ ++++
Sbjct: 709 AKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIW 742
Score = 33.9 bits (76), Expect = 0.72
Identities = 24/112 (21%), Positives = 49/112 (43%), Gaps = 8/112 (7%)
Query: 601 VLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVG--SHDNFIYLYVVSENGRKYSRYGR 658
+LD + I + LS + +S DG ++ G H + ++ V E ++
Sbjct: 95 ILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEK----NQVAE 150
Query: 659 CTGHSSYITHLDWSPDNKYIMSNSGDYEIL--YWDIPNGCKLIRNRSDCKDI 708
GH + + +SP+ K+I+S ++++ WD + N+ C+ I
Sbjct: 151 MLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVI 202
>gi|145580610 WD repeat domain 62 isoform 2 [Homo sapiens]
Length = 1518
Score = 60.8 bits (146), Expect = 5e-09
Identities = 46/157 (29%), Positives = 75/157 (47%), Gaps = 15/157 (9%)
Query: 223 TGEIVYFIASVVVLFNYEERTQRHYLGHT-DCVKCLAIHPDKIRIATGQIAGVDKDGRPL 281
TG + Y VVV+ + +E Q+H + LA PD I TG+ +G
Sbjct: 82 TGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGE------NGH-- 133
Query: 282 QPHVRVWDSVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCVIDDSNEHMLTVWDWQKK 341
+P VR+WD + Q+ + + GV C+ FS + H+ + ++ +L VWDW+K
Sbjct: 134 RPAVRIWDVEEKN--QVAEMLGHKYGVACVAFSP--NMKHIVSMGYQHDMVLNVWDWKKD 189
Query: 342 AKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFW 378
A K + V+ A+ F D++ +T G H+ FW
Sbjct: 190 IVVASNKVSCRVI-ALSF-SEDSSYFVTVGNRHVRFW 224
Score = 34.3 bits (77), Expect = 0.55
Identities = 45/214 (21%), Positives = 91/214 (42%), Gaps = 15/214 (7%)
Query: 446 QIKAHDGSVFTL--CQMRNGM-LLTGGGKDRKIILWDHDLNPEREIEVPDQYGTIRAVA- 501
+++AHD V L + G+ LL +DR I + + + N E + D +I A+
Sbjct: 529 KVEAHDAEVLCLEYSKPETGLTLLASASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKF 588
Query: 502 EGKADQFLV--GTSRNFILRGTF--NDGFQIEVQGHTDE---LWGLATHPFKDLLLTCAQ 554
G D ++ G ++ R +DG H E L+ + + + Q
Sbjct: 589 AGNRDIQMISCGADKSIYFRSAQQGSDGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQ 648
Query: 555 DRQVCLWNSMEHRLE--WTRLVDEPGHCADFH--PSGTVVAIGTHSGRWFVLDAETRDLV 610
DR V ++N++ + + + + G H PSGT +A V+D + + +
Sbjct: 649 DRNVRVYNTVNGKQKKCYKGSQGDEGSLLKVHVDPSGTFLATSCSDKSISVIDFYSGECI 708
Query: 611 SIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLY 644
+ +E ++ M+++ D L S D+ ++++
Sbjct: 709 AKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIW 742
Score = 33.9 bits (76), Expect = 0.72
Identities = 24/112 (21%), Positives = 49/112 (43%), Gaps = 8/112 (7%)
Query: 601 VLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVG--SHDNFIYLYVVSENGRKYSRYGR 658
+LD + I + LS + +S DG ++ G H + ++ V E ++
Sbjct: 95 ILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEK----NQVAE 150
Query: 659 CTGHSSYITHLDWSPDNKYIMSNSGDYEIL--YWDIPNGCKLIRNRSDCKDI 708
GH + + +SP+ K+I+S ++++ WD + N+ C+ I
Sbjct: 151 MLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVI 202
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 58.9 bits (141), Expect = 2e-08
Identities = 77/386 (19%), Positives = 155/386 (40%), Gaps = 56/386 (14%)
Query: 528 IEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCA-DFHPS 586
+ + GHT + + + ++L++ +Q + +W+ ++ T + + C+ DFHP
Sbjct: 57 MSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPY 116
Query: 587 GTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVV 646
G VA G+ + D + V + ++ + +R+S DG +LA + D+ + L+ +
Sbjct: 117 GEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDL 176
Query: 647 SENGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCK 706
+ G+ S + GH+ + +++ P+ + S S D I +WD+
Sbjct: 177 TA-GKMMSEF---PGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEK------------ 220
Query: 707 DIDWTTYTCVLGFQVFGVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAK 766
+ +C+ EG G + L + + D +V+ ++
Sbjct: 221 ---FQVVSCI----------EGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWE------- 260
Query: 767 APSHKYS---AHSSHVTNVSFTHNDSHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTL 823
P + + V +++ ++ LI ++ + +V+ + + TVA
Sbjct: 261 -PERCFDVVLVNWGKVADLAICND--QLIGVAFSQSNVSSY-VVDLTRVTRTGTVA---- 312
Query: 824 TKAPVSSTESVIQSNTPTPPPSQPLNETAEEESRISSSP-TLLENSLEQTVEPSEDHSEE 882
+ PV + Q P P PS PL E S S P + +NS + PS + +
Sbjct: 313 -RDPVQDHRPLAQ---PLPNPSAPLRRIYERPSTTCSKPQRVKQNSESERRSPSSEDDRD 368
Query: 883 ESEEGSGDLGEPLYEE---PCNEISK 905
E E + Y E P N IS+
Sbjct: 369 ERESRAEIQNAEDYNEIFQPKNSISR 394
Score = 48.1 bits (113), Expect = 4e-05
Identities = 41/154 (26%), Positives = 66/154 (42%), Gaps = 15/154 (9%)
Query: 548 LLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCADFH------PSGTVVAIGTHSGRWFV 601
LL T D +V LW+ + ++ GH + P +VA G+ SG V
Sbjct: 35 LLATGGDDCRVNLWSINKPNC----IMSLTGHTSPVESVRLNTPEELIVA-GSQSGSIRV 89
Query: 602 LDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCTG 661
D E ++ + + + G F+A GS D I L+ + G + R G
Sbjct: 90 WDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVF----RYRG 145
Query: 662 HSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNG 695
HS + L +SPD K++ S + D+ + WD+ G
Sbjct: 146 HSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAG 179
Score = 32.3 bits (72), Expect = 2.1
Identities = 34/157 (21%), Positives = 56/157 (35%), Gaps = 18/157 (11%)
Query: 324 VIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWTWSGN 383
++ S + VWD + + + +++FHP ++I W
Sbjct: 78 IVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLW----- 132
Query: 384 SLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGG-VMLIWSKTTVEPTPGKGPKGVYQ 442
+ RK +F + V+CL F +G L + + +W T GK
Sbjct: 133 DIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTA-----GK------- 180
Query: 443 ISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWD 479
+ + H G V + N LL G DR I WD
Sbjct: 181 MMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD 217
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 57.4 bits (137), Expect = 6e-08
Identities = 47/187 (25%), Positives = 77/187 (41%), Gaps = 15/187 (8%)
Query: 531 QGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEH---RLEWTRLVDEPGHCADFHPSG 587
+GH +W P+ ++ DR LW + + R+ L D +C FHP+
Sbjct: 582 KGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADV--NCTRFHPNS 639
Query: 588 TVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVS 647
VA G+ + D + V I T + + +S +G FLA G+ D + L+ +
Sbjct: 640 NYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIG 699
Query: 648 ENGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKD 707
G GH+ + L +S D + + S S D + WD I+ D +
Sbjct: 700 HG----LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD------AIKAFEDLET 749
Query: 708 IDWTTYT 714
D+TT T
Sbjct: 750 DDFTTAT 756
Score = 55.1 bits (131), Expect = 3e-07
Identities = 55/243 (22%), Positives = 103/243 (42%), Gaps = 37/243 (15%)
Query: 465 LLTGGGKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFND 524
L+ GG D + +W + P++ +R+V + +D L+ + +L ++
Sbjct: 484 LIAGGFADSTVRVWS--VTPKK----------LRSVKQA-SDLSLIDKESDDVLERIMDE 530
Query: 525 GFQIEVQ---GHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHC- 580
E++ GH+ ++G + P ++ LL+ ++D V LW+ +T LV GH
Sbjct: 531 KTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQT----FTCLVGYKGHNY 586
Query: 581 ----ADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGS 636
F P G G H + + + I ++ R+ + ++A GS
Sbjct: 587 PVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGS 646
Query: 637 HDNFIYLYVVSENGRKYSRYGRC----TGHSSYITHLDWSPDNKYIMSNSGDYEILYWDI 692
D + L+ V G C TGH I L +SP+ +++ + + D +L WDI
Sbjct: 647 ADRTVRLWDVLN--------GNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDI 698
Query: 693 PNG 695
+G
Sbjct: 699 GHG 701
Score = 37.0 bits (84), Expect = 0.085
Identities = 31/149 (20%), Positives = 58/149 (38%), Gaps = 34/149 (22%)
Query: 661 GHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQ 720
GHS + +SPD Y++S+S D + W + T+TC++G++
Sbjct: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQ------------------TFTCLVGYK 582
Query: 721 V--FGVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSH 778
+ VW + H+R A D + P ++ H +
Sbjct: 583 GHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQ-------------PLRIFAGHLAD 629
Query: 779 VTNVSFTHNDSHLISTGGKDMSIIQWKLV 807
V F H +S+ ++TG D ++ W ++
Sbjct: 630 VNCTRF-HPNSNYVATGSADRTVRLWDVL 657
Score = 34.3 bits (77), Expect = 0.55
Identities = 32/127 (25%), Positives = 48/127 (37%), Gaps = 18/127 (14%)
Query: 354 VLAVEFHPTDANTIITCGKSHIFFWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVL 413
V FHP + W + R IF ++ P + L F NG L
Sbjct: 630 VNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVR---IFTGHKGP--IHSLTFSPNGRFL 684
Query: 414 -TGDSGGVMLIWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKD 472
TG + G +L+W G + ++K H +V +L R+G +L G D
Sbjct: 685 ATGATDGRVLLWDI------------GHGLMVGELKGHTDTVCSLRFSRDGEILASGSMD 732
Query: 473 RKIILWD 479
+ LWD
Sbjct: 733 NTVRLWD 739
Score = 32.3 bits (72), Expect = 2.1
Identities = 27/106 (25%), Positives = 46/106 (43%), Gaps = 3/106 (2%)
Query: 462 NGMLLTGGGKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLV-GTSRNFILRG 520
N + G DR + LWD LN G I ++ +FL G + +L
Sbjct: 638 NSNYVATGSADRTVRLWDV-LNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLW 696
Query: 521 TFNDGFQI-EVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSME 565
G + E++GHTD + L ++L + + D V LW++++
Sbjct: 697 DIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIK 742
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 54.7 bits (130), Expect = 4e-07
Identities = 62/303 (20%), Positives = 114/303 (37%), Gaps = 59/303 (19%)
Query: 526 FQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGH---CAD 582
F+ ++GHTD + ++ LL +C+ D + LW+ E R + H
Sbjct: 142 FERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDF--QGFECIRTMHGHDHNVSSVA 199
Query: 583 FHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIY 642
P+G + + + + +T V T E + ++R + DGT +A S+D +
Sbjct: 200 IMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVR 259
Query: 643 LYVVSENGRKYSRYGRCTGHSSYITHLDWSPDNKY--------------------IMSNS 682
++VV+ K H + + W+P++ Y ++S S
Sbjct: 260 VWVVATKECK----AELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGS 315
Query: 683 GDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPEGSDGTDINALVRSHN 742
D I WD+ G C++ W G L S
Sbjct: 316 RDKTIKMWDVSTG------------------MCLMTLVGHDNWVRG-------VLFHSGG 350
Query: 743 RKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTGGKDMSII 802
+ +++ ADD + ++ Y K K +AH VT++ F H + + TG D ++
Sbjct: 351 KFILSCADD-KTLRVWDY---KNKRCMKTLNAHEHFVTSLDF-HKTAPYVVTGSVDQTVK 405
Query: 803 QWK 805
W+
Sbjct: 406 VWE 408
Score = 38.1 bits (87), Expect = 0.038
Identities = 59/261 (22%), Positives = 101/261 (38%), Gaps = 46/261 (17%)
Query: 445 KQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWD-HDLNPEREIEVPDQYGTIRAVAEG 503
+ +K H SV + +G LL D I LWD R + D + +VA
Sbjct: 144 RTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDH--NVSSVAIM 201
Query: 504 KADQFLVGTSRNFILR-GTFNDGFQIEV-QGHTDELWGLATHPFKD--LLLTCAQDRQVC 559
+V SR+ ++ G+ ++ GH + W P +D L+ +C+ D+ V
Sbjct: 202 PNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHRE--WVRMVRPNQDGTLIASCSNDQTVR 259
Query: 560 LW--NSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGN 617
+W + E + E R + C + P + +I +G +ET+
Sbjct: 260 VWVVATKECKAE-LREHEHVVECISWAPESSYSSISEATG------SETK---------- 302
Query: 618 EQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRC----TGHSSYITHLDWSP 673
+ G FL GS D I ++ VS G C GH +++ + +
Sbjct: 303 ------KSGKPGPFLLSGSRDKTIKMWDVST--------GMCLMTLVGHDNWVRGVLFHS 348
Query: 674 DNKYIMSNSGDYEILYWDIPN 694
K+I+S + D + WD N
Sbjct: 349 GGKFILSCADDKTLRVWDYKN 369
Score = 31.6 bits (70), Expect = 3.6
Identities = 27/124 (21%), Positives = 51/124 (41%), Gaps = 18/124 (14%)
Query: 250 HTDCVKCLAIHPDKIRIATGQIAGVD--KDGRP--------LQPHVRVWD-SVTLSTLQI 298
H V+C++ P+ + + G + K G+P +++WD S + + +
Sbjct: 275 HEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTL 334
Query: 299 IGLGTFERGVGCLDFSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVE 358
+G + RGV F + C D + L VWD++ K + V +++
Sbjct: 335 VGHDNWVRGVL---FHSGGKFILSCADDKT----LRVWDYKNKRCMKTLNAHEHFVTSLD 387
Query: 359 FHPT 362
FH T
Sbjct: 388 FHKT 391
>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
sapiens]
Length = 504
Score = 54.7 bits (130), Expect = 4e-07
Identities = 52/288 (18%), Positives = 115/288 (39%), Gaps = 37/288 (12%)
Query: 511 GTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHR-LE 569
G +N ++ ++ ++GHT ++ + HP +DL+ + + D + +W+ ++
Sbjct: 241 GADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQ 300
Query: 570 WTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNE--QLSVMRYSI 627
R + H +G + + W D +T +++ TD L+ ++
Sbjct: 301 VVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHP 360
Query: 628 DGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEI 687
DG G+ D+ I ++ + E + GHS IT + +S + Y+ + + D +
Sbjct: 361 DGLIFGTGTMDSQIKIWDLKER----TNVANFPGHSGPITSIAFSENGYYLATAADDSSV 416
Query: 688 LYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPEGSDGTDINALVRSHNRKVIA 747
WD +R + K + + + ++ +L+ + +A
Sbjct: 417 KLWD-------LRKLKNFKTL------------------QLDNNFEVKSLIFDQSGTYLA 451
Query: 748 VADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTG 795
+ ++ Y C + H ++ HS T V+F H+ + STG
Sbjct: 452 LGGTDVQI----YICKQWTEILH-FTEHSGLTTGVAFGHHAKFIASTG 494
Score = 49.7 bits (117), Expect = 1e-05
Identities = 45/214 (21%), Positives = 91/214 (42%), Gaps = 14/214 (6%)
Query: 442 QISKQIKAHDGSV-----FTLCQMRNGMLLTGGGKDRKIILWDHDLNPEREIEVPDQYGT 496
Q++ + H S+ LC +LTGG D+ ++++D + + +
Sbjct: 209 QVASHVGLHSASIPGILALDLCPSDTNKILTGGA-DKNVVVFDKS-SEQILATLKGHTKK 266
Query: 497 IRAVAEGKADQFLVGTSRNFILR--GTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQ 554
+ +V + + S + +R N V+ H + GL+ H D LL+ +
Sbjct: 267 VTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSD 326
Query: 555 DRQVCLWNSMEHRLEWTRLVDEPGHC----ADFHPSGTVVAIGTHSGRWFVLDAETRDLV 610
D Q ++ ++ T++ DE C A FHP G + GT + + D + R V
Sbjct: 327 D-QYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNV 385
Query: 611 SIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLY 644
+ + ++ + +S +G +LA + D+ + L+
Sbjct: 386 ANFPGHSGPITSIAFSENGYYLATAADDSSVKLW 419
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 54.3 bits (129), Expect = 5e-07
Identities = 51/234 (21%), Positives = 94/234 (40%), Gaps = 12/234 (5%)
Query: 462 NGMLLTGGGKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILR-- 519
+G LL G +D+ + +W ++ E + T+R+V Q V S + ++
Sbjct: 34 SGHLLASGSRDKTVRIWVPNVKGESTV-FRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 92
Query: 520 GTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGH 579
T F + H + + P L+++ + D+ V LW+ E E G
Sbjct: 93 ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR--ECVHSYCEHGG 150
Query: 580 CA---DFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGS 636
DFHPSGT +A V D T L+ + + ++ + + G +L S
Sbjct: 151 FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITAS 210
Query: 637 HDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYW 690
D+ + + + E Y+ + GH T + +S +Y S D +++ W
Sbjct: 211 SDSTLKILDLMEGRLLYTLH----GHQGPATTVAFSRTGEYFASGGSDEQVMVW 260
Score = 36.2 bits (82), Expect = 0.14
Identities = 65/322 (20%), Positives = 116/322 (36%), Gaps = 48/322 (14%)
Query: 580 CADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDN 639
C +F PSG ++A G+ + + ++ + + + DG S D
Sbjct: 28 CVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK 87
Query: 640 FIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLI 699
+ ++ +S + H +++ +SPD + I+S S D + WD K
Sbjct: 88 TVKVWATHRQKFLFS----LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD-----KSS 138
Query: 700 RN--RSDCKDIDWTTYTCVLGFQVFG--VWPEGSDGTDINALVRSH----NRKVIAVADD 751
R S C+ + TY + F G + G D T VR+H + ++ + A +
Sbjct: 139 RECVHSYCEHGGFVTY---VDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN 195
Query: 752 FCKVHLFQYPCSKAKAPS-------------HKYSAHSSHVTNVSFTHNDSHLISTGGKD 798
H A + S + H T V+F+ + S GG D
Sbjct: 196 GLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFAS-GGSD 254
Query: 799 MSIIQWKLVEKLSLPQNETVADTTLTKAP------VSSTESVIQSNTPTPP-PSQPLNET 851
++ WK + V +TK P SS ++ + + P PP + +
Sbjct: 255 EQVMVWK-------SNFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGRGRSVESV 307
Query: 852 AEEESRISSSPTLLENSLEQTV 873
+ S P L ++LE V
Sbjct: 308 QSQPQEPVSVPQTLTSTLEHIV 329
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 54.3 bits (129), Expect = 5e-07
Identities = 51/234 (21%), Positives = 94/234 (40%), Gaps = 12/234 (5%)
Query: 462 NGMLLTGGGKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILR-- 519
+G LL G +D+ + +W ++ E + T+R+V Q V S + ++
Sbjct: 72 SGHLLASGSRDKTVRIWVPNVKGESTV-FRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130
Query: 520 GTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGH 579
T F + H + + P L+++ + D+ V LW+ E E G
Sbjct: 131 ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR--ECVHSYCEHGG 188
Query: 580 CA---DFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGS 636
DFHPSGT +A V D T L+ + + ++ + + G +L S
Sbjct: 189 FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITAS 248
Query: 637 HDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYW 690
D+ + + + E Y+ + GH T + +S +Y S D +++ W
Sbjct: 249 SDSTLKILDLMEGRLLYTLH----GHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 39.3 bits (90), Expect = 0.017
Identities = 48/207 (23%), Positives = 81/207 (39%), Gaps = 32/207 (15%)
Query: 618 EQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPDNKY 677
+ ++ + +SI+ LA GS D+ + ++ + R Y R TGH +T +++SP
Sbjct: 20 DAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAY----RFTGHKDAVTCVNFSPSGHL 75
Query: 678 IMSNSGDYEILYWDIPN----------GCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPE 727
+ S S D + W +PN +R+ C D ++ + VW
Sbjct: 76 LASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCS--DGQSFVTASDDKTVKVWAT 132
Query: 728 G------SDGTDIN----ALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSS 777
S IN A R +++ +DD V L+ ++ H Y H
Sbjct: 133 HRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDD-KTVKLWD---KSSRECVHSYCEHGG 188
Query: 778 HVTNVSFTHNDSHLISTGGKDMSIIQW 804
VT V F H I+ G D ++ W
Sbjct: 189 FVTYVDF-HPSGTCIAAAGMDNTVKVW 214
Score = 34.7 bits (78), Expect = 0.42
Identities = 63/329 (19%), Positives = 115/329 (34%), Gaps = 75/329 (22%)
Query: 244 QRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGT 303
+RH+ GH D V C+ I T Q+A D + H++ T
Sbjct: 12 ERHFKGHRDAVTCV-----DFSINTKQLASGSMDSCLMVWHMKPQSRAYRFT-------G 59
Query: 304 FERGVGCLDFSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTD 363
+ V C++FS + HL + S + + +W K + + V +V F
Sbjct: 60 HKDAVTCVNFSPSG---HL-LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDG 115
Query: 364 ANTIITCGKSHIFFWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGG-VML 422
+ + + W + R++ +F + +V+C F +G ++ S +
Sbjct: 116 QSFVTASDDKTVKVW-----ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVK 170
Query: 423 IWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDL 482
+W K++ E H G V + +G + G D + +WD
Sbjct: 171 LWDKSSRE------------CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD--- 215
Query: 483 NPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLAT 542
V T R +L+ Q H+ + GL+
Sbjct: 216 ---------------------------VRTHR--LLQ---------HYQLHSAAVNGLSF 237
Query: 543 HPFKDLLLTCAQDRQVCLWNSMEHRLEWT 571
HP + L+T + D + + + ME RL +T
Sbjct: 238 HPSGNYLITASSDSTLKILDLMEGRLLYT 266
Score = 34.3 bits (77), Expect = 0.55
Identities = 22/112 (19%), Positives = 45/112 (40%), Gaps = 4/112 (3%)
Query: 580 CADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDN 639
C +F PSG ++A G+ + + ++ + + + DG S D
Sbjct: 66 CVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK 125
Query: 640 FIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWD 691
+ ++ +S + H +++ +SPD + I+S S D + WD
Sbjct: 126 TVKVWATHRQKFLFS----LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 173
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 54.3 bits (129), Expect = 5e-07
Identities = 51/234 (21%), Positives = 94/234 (40%), Gaps = 12/234 (5%)
Query: 462 NGMLLTGGGKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILR-- 519
+G LL G +D+ + +W ++ E + T+R+V Q V S + ++
Sbjct: 72 SGHLLASGSRDKTVRIWVPNVKGESTV-FRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130
Query: 520 GTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGH 579
T F + H + + P L+++ + D+ V LW+ E E G
Sbjct: 131 ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR--ECVHSYCEHGG 188
Query: 580 CA---DFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGS 636
DFHPSGT +A V D T L+ + + ++ + + G +L S
Sbjct: 189 FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITAS 248
Query: 637 HDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYW 690
D+ + + + E Y+ + GH T + +S +Y S D +++ W
Sbjct: 249 SDSTLKILDLMEGRLLYTLH----GHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 39.3 bits (90), Expect = 0.017
Identities = 48/207 (23%), Positives = 81/207 (39%), Gaps = 32/207 (15%)
Query: 618 EQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPDNKY 677
+ ++ + +SI+ LA GS D+ + ++ + R Y R TGH +T +++SP
Sbjct: 20 DAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAY----RFTGHKDAVTCVNFSPSGHL 75
Query: 678 IMSNSGDYEILYWDIPN----------GCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPE 727
+ S S D + W +PN +R+ C D ++ + VW
Sbjct: 76 LASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCS--DGQSFVTASDDKTVKVWAT 132
Query: 728 G------SDGTDIN----ALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSS 777
S IN A R +++ +DD V L+ ++ H Y H
Sbjct: 133 HRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDD-KTVKLWD---KSSRECVHSYCEHGG 188
Query: 778 HVTNVSFTHNDSHLISTGGKDMSIIQW 804
VT V F H I+ G D ++ W
Sbjct: 189 FVTYVDF-HPSGTCIAAAGMDNTVKVW 214
Score = 36.2 bits (82), Expect = 0.14
Identities = 65/322 (20%), Positives = 116/322 (36%), Gaps = 48/322 (14%)
Query: 580 CADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDN 639
C +F PSG ++A G+ + + ++ + + + DG S D
Sbjct: 66 CVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK 125
Query: 640 FIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLI 699
+ ++ +S + H +++ +SPD + I+S S D + WD K
Sbjct: 126 TVKVWATHRQKFLFS----LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD-----KSS 176
Query: 700 RN--RSDCKDIDWTTYTCVLGFQVFG--VWPEGSDGTDINALVRSH----NRKVIAVADD 751
R S C+ + TY + F G + G D T VR+H + ++ + A +
Sbjct: 177 RECVHSYCEHGGFVTY---VDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN 233
Query: 752 FCKVHLFQYPCSKAKAPS-------------HKYSAHSSHVTNVSFTHNDSHLISTGGKD 798
H A + S + H T V+F+ + S GG D
Sbjct: 234 GLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFAS-GGSD 292
Query: 799 MSIIQWKLVEKLSLPQNETVADTTLTKAP------VSSTESVIQSNTPTPP-PSQPLNET 851
++ WK + V +TK P SS ++ + + P PP + +
Sbjct: 293 EQVMVWK-------SNFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGRGRSVESV 345
Query: 852 AEEESRISSSPTLLENSLEQTV 873
+ S P L ++LE V
Sbjct: 346 QSQPQEPVSVPQTLTSTLEHIV 367
Score = 34.7 bits (78), Expect = 0.42
Identities = 63/329 (19%), Positives = 115/329 (34%), Gaps = 75/329 (22%)
Query: 244 QRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGT 303
+RH+ GH D V C+ I T Q+A D + H++ T
Sbjct: 12 ERHFKGHRDAVTCV-----DFSINTKQLASGSMDSCLMVWHMKPQSRAYRFT-------G 59
Query: 304 FERGVGCLDFSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTD 363
+ V C++FS + HL + S + + +W K + + V +V F
Sbjct: 60 HKDAVTCVNFSPSG---HL-LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDG 115
Query: 364 ANTIITCGKSHIFFWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGG-VML 422
+ + + W + R++ +F + +V+C F +G ++ S +
Sbjct: 116 QSFVTASDDKTVKVW-----ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVK 170
Query: 423 IWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDL 482
+W K++ E H G V + +G + G D + +WD
Sbjct: 171 LWDKSSRE------------CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD--- 215
Query: 483 NPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLAT 542
V T R +L+ Q H+ + GL+
Sbjct: 216 ---------------------------VRTHR--LLQ---------HYQLHSAAVNGLSF 237
Query: 543 HPFKDLLLTCAQDRQVCLWNSMEHRLEWT 571
HP + L+T + D + + + ME RL +T
Sbjct: 238 HPSGNYLITASSDSTLKILDLMEGRLLYT 266
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 53.9 bits (128), Expect = 7e-07
Identities = 91/403 (22%), Positives = 144/403 (35%), Gaps = 52/403 (12%)
Query: 531 QGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGH-----CADFHP 585
+GH + L P L T + D + LWN H R GH F P
Sbjct: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPH----ARAYRYVGHKDVVTSVQFSP 70
Query: 586 SGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYV 645
G ++A + + + R S + + +S DG FLA S D I ++
Sbjct: 71 HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWS 130
Query: 646 VSENGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSD- 704
+ YS Y H+ ++ +SPD + I+S S D I WD N + + N SD
Sbjct: 131 MYRQRFLYSLYR----HTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNK-QCVNNFSDS 185
Query: 705 ---CKDIDWT-TYTCVLGF---QVFGVW-----------PEGSDGTDINALVRSHNRKVI 746
+D+ + TC+ Q VW S G + + S N +
Sbjct: 186 VGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLIT 245
Query: 747 AVADDFCKV-HLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTGGKDMSIIQWK 805
A +D K+ L + + H+ V VSF+ L ++GG D ++ W+
Sbjct: 246 ASSDGTLKILDLLE------GRLIYTLQGHTGPVFTVSFS-KGGELFASGGADTQVLLWR 298
Query: 806 LVEKLSLPQNETVADTTLTKAPVSSTESVIQSNTPTPPPSQPLNETAE-------EESRI 858
+ + L + S ++ TP P + ET E + +I
Sbjct: 299 --TNFDELHCKGLTKRNLKRLHFDSPPHLLDIYPRTPHPHEEKVETVEINPKLEVIDLQI 356
Query: 859 SSSPT--LLENSLEQTVEPSEDHSEEESEEGSGDLGEPLYEEP 899
S+ P +L T E S ++ EE G P P
Sbjct: 357 STPPVMDILSFDSTTTTETSGRTLPDKGEEACGYFLNPSLMSP 399
Score = 52.4 bits (124), Expect = 2e-06
Identities = 48/233 (20%), Positives = 92/233 (39%), Gaps = 10/233 (4%)
Query: 462 NGMLLTGGGKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILR-- 519
+G LL +DR + LW D + E +R+V QFL S + ++
Sbjct: 71 HGNLLASASRDRTVRLWIPDKRGKFS-EFKAHTAPVRSVDFSADGQFLATASEDKSIKVW 129
Query: 520 GTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGH 579
+ F + HT + P L+++C++D+ + +W++ + D G
Sbjct: 130 SMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCV-NNFSDSVGF 188
Query: 580 C--ADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSH 637
DF+PSGT +A V D L+ + + ++ + + G +L S
Sbjct: 189 ANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASS 248
Query: 638 DNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYW 690
D + + + E Y+ GH+ + + +S + S D ++L W
Sbjct: 249 DGTLKILDLLEGRLIYT----LQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
Score = 44.7 bits (104), Expect = 4e-04
Identities = 50/263 (19%), Positives = 97/263 (36%), Gaps = 22/263 (8%)
Query: 443 ISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPEREIEVPDQYGTIRAVAE 502
+ + K H ++ +L NG L D ++LW+ + R + +V
Sbjct: 10 LERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPH-ARAYRYVGHKDVVTSVQF 68
Query: 503 GKADQFLVGTSRNFILRGTFND--GFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCL 560
L SR+ +R D G E + HT + + L T ++D+ + +
Sbjct: 69 SPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKV 128
Query: 561 WN--------SMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSI 612
W+ S+ W R CA F P G ++ + + D + V+
Sbjct: 129 WSMYRQRFLYSLYRHTHWVR-------CAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
Query: 613 HTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDWS 672
+D + + ++ GT +A D + ++ V N + Y HS + + +
Sbjct: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVN-KLLQHY---QVHSGGVNCISFH 237
Query: 673 PDNKYIMSNSGDYEILYWDIPNG 695
P Y+++ S D + D+ G
Sbjct: 238 PSGNYLITASSDGTLKILDLLEG 260
Score = 40.0 bits (92), Expect = 0.010
Identities = 54/271 (19%), Positives = 101/271 (37%), Gaps = 32/271 (11%)
Query: 328 SNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSH-IFFWTWSGNSLT 386
S + + +W K+ K +E K V +V+F D + T + I W S+
Sbjct: 79 SRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFS-ADGQFLATASEDKSIKVW-----SMY 132
Query: 387 RKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVML-IWSKTTVEPTPGKGPKGVYQISK 445
R++ ++ Y +V+C F +G ++ S + IW T + V S
Sbjct: 133 RQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQC--------VNNFSD 184
Query: 446 QIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKA 505
+ + F +G + G D+ + +WD +N + G + ++ +
Sbjct: 185 SVGFANFVDFN----PSGTCIASAGSDQTVKVWDVRVNKLLQ-HYQVHSGGVNCISFHPS 239
Query: 506 DQFLVGTSRNFILR--GTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNS 563
+L+ S + L+ +QGHT ++ ++ +L + D QV LW +
Sbjct: 240 GNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRT 299
Query: 564 MEHRLEWTRLV---------DEPGHCADFHP 585
L L D P H D +P
Sbjct: 300 NFDELHCKGLTKRNLKRLHFDSPPHLLDIYP 330
Score = 38.9 bits (89), Expect = 0.022
Identities = 65/327 (19%), Positives = 108/327 (33%), Gaps = 93/327 (28%)
Query: 157 HKDVIINQE----GEYIKMFMRGRPITMFIPSDVDNYDDIRTELPPEKLKLEWAYGYRGK 212
HKDV+ + + G + R R + ++IP + + + P R
Sbjct: 59 HKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAP----------VRSV 108
Query: 213 DCRANVYLLPTGEIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAIHPDKIRIATGQIA 272
D A+ L T S+ V Y +R HT V+C PD I +
Sbjct: 109 DFSADGQFLATASED---KSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVS---C 162
Query: 273 GVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLDFSKAD-SGVHLCVIDDSNEH 331
DK +++WD+ + F VG +F + SG C+ ++
Sbjct: 163 SEDKT-------IKIWDTTNKQCVN-----NFSDSVGFANFVDFNPSGT--CIASAGSDQ 208
Query: 332 MLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWTWSGNSLTRKQGI 391
+ VWD + + + V + FHP SGN L
Sbjct: 209 TVKVWDVRVNKLLQHYQVHSGGVNCISFHP-------------------SGNYL------ 243
Query: 392 FGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKGPKGVYQISKQIKAHD 451
+T S G + I ++ G+ + ++ H
Sbjct: 244 ---------------------ITASSDGTLKI-----LDLLEGR-------LIYTLQGHT 270
Query: 452 GSVFTLCQMRNGMLLTGGGKDRKIILW 478
G VFT+ + G L GG D +++LW
Sbjct: 271 GPVFTVSFSKGGELFASGGADTQVLLW 297
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 53.5 bits (127), Expect = 9e-07
Identities = 65/300 (21%), Positives = 116/300 (38%), Gaps = 62/300 (20%)
Query: 530 VQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEW-TRLVDEPGHCADFHPSGT 588
++GH E++ A +P DLL + + D +WN E+ T+LV HC
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLR--HC-------- 224
Query: 589 VVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSE 648
+ G H N+ ++ + ++ DGT LA+GS+D F ++ +E
Sbjct: 225 -IREGGHD-----------------VPSNKDVTSLDWNSDGTLLAMGSYDGFARIW--TE 264
Query: 649 NGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNG---CKLIRNRSDC 705
NG S G+ H I L W+ Y++S D + WD G + + +
Sbjct: 265 NGNLASTLGQ---HKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPA 321
Query: 706 KDIDWTT-------------YTCVLGFQVFGVWPEGSDGTDINALVRSHNRKVIAVADDF 752
D+DW + C LG V ++NA+ + ++A D
Sbjct: 322 LDVDWQNNMTFASCSTDMCIHVCRLGCD-HPVKTFQGHTNEVNAIKWDPSGMLLASCSDD 380
Query: 753 CKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFT--------HNDSHLISTGGKDMSIIQW 804
+ ++ K A H AHS + + ++ N S ++++ D ++ W
Sbjct: 381 MTLKIWS---MKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLW 437
Score = 40.4 bits (93), Expect = 0.008
Identities = 48/261 (18%), Positives = 99/261 (37%), Gaps = 17/261 (6%)
Query: 443 ISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPEREIEVPDQYGTIRAVAE 502
++ + H G +F L + G + G D+ I+WD ++ + P V
Sbjct: 268 LASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQ-QFPFHSAPALDVDW 326
Query: 503 GKADQFLVGTSRNFILRGTFNDGFQIEV-QGHTDELWGLATHPFKDLLLTCAQDRQVCLW 561
F ++ I ++ QGHT+E+ + P LL +C+ D + +W
Sbjct: 327 QNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 386
Query: 562 NSME---------HRLEWTRLVDEPGHCADFHPSGTV-VAIGTHSGRWFVLDAETRDLVS 611
+ + H E + P A +P+ ++ +A + + D E
Sbjct: 387 SMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTH 446
Query: 612 IHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDW 671
E + + +S DG +LA GS D +++++ +S G + I + W
Sbjct: 447 TLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG-----TGGIFEVCW 501
Query: 672 SPDNKYIMSNSGDYEILYWDI 692
+ + +++ D + D+
Sbjct: 502 NARGDKVGASASDGSVCVLDL 522
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 53.5 bits (127), Expect = 9e-07
Identities = 65/300 (21%), Positives = 116/300 (38%), Gaps = 62/300 (20%)
Query: 530 VQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEW-TRLVDEPGHCADFHPSGT 588
++GH E++ A +P DLL + + D +WN E+ T+LV HC
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLR--HC-------- 224
Query: 589 VVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSE 648
+ G H N+ ++ + ++ DGT LA+GS+D F ++ +E
Sbjct: 225 -IREGGHD-----------------VPSNKDVTSLDWNSDGTLLAMGSYDGFARIW--TE 264
Query: 649 NGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNG---CKLIRNRSDC 705
NG S G+ H I L W+ Y++S D + WD G + + +
Sbjct: 265 NGNLASTLGQ---HKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPA 321
Query: 706 KDIDWTT-------------YTCVLGFQVFGVWPEGSDGTDINALVRSHNRKVIAVADDF 752
D+DW + C LG V ++NA+ + ++A D
Sbjct: 322 LDVDWQNNMTFASCSTDMCIHVCRLGCD-HPVKTFQGHTNEVNAIKWDPSGMLLASCSDD 380
Query: 753 CKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFT--------HNDSHLISTGGKDMSIIQW 804
+ ++ K A H AHS + + ++ N S ++++ D ++ W
Sbjct: 381 MTLKIWS---MKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLW 437
Score = 40.4 bits (93), Expect = 0.008
Identities = 48/261 (18%), Positives = 99/261 (37%), Gaps = 17/261 (6%)
Query: 443 ISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPEREIEVPDQYGTIRAVAE 502
++ + H G +F L + G + G D+ I+WD ++ + P V
Sbjct: 268 LASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQ-QFPFHSAPALDVDW 326
Query: 503 GKADQFLVGTSRNFILRGTFNDGFQIEV-QGHTDELWGLATHPFKDLLLTCAQDRQVCLW 561
F ++ I ++ QGHT+E+ + P LL +C+ D + +W
Sbjct: 327 QNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 386
Query: 562 NSME---------HRLEWTRLVDEPGHCADFHPSGTV-VAIGTHSGRWFVLDAETRDLVS 611
+ + H E + P A +P+ ++ +A + + D E
Sbjct: 387 SMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTH 446
Query: 612 IHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDW 671
E + + +S DG +LA GS D +++++ +S G + I + W
Sbjct: 447 TLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG-----TGGIFEVCW 501
Query: 672 SPDNKYIMSNSGDYEILYWDI 692
+ + +++ D + D+
Sbjct: 502 NARGDKVGASASDGSVCVLDL 522
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 53.5 bits (127), Expect = 9e-07
Identities = 65/300 (21%), Positives = 116/300 (38%), Gaps = 62/300 (20%)
Query: 530 VQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEW-TRLVDEPGHCADFHPSGT 588
++GH E++ A +P DLL + + D +WN E+ T+LV HC
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLR--HC-------- 224
Query: 589 VVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSE 648
+ G H N+ ++ + ++ DGT LA+GS+D F ++ +E
Sbjct: 225 -IREGGHD-----------------VPSNKDVTSLDWNSDGTLLAMGSYDGFARIW--TE 264
Query: 649 NGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNG---CKLIRNRSDC 705
NG S G+ H I L W+ Y++S D + WD G + + +
Sbjct: 265 NGNLASTLGQ---HKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPA 321
Query: 706 KDIDWTT-------------YTCVLGFQVFGVWPEGSDGTDINALVRSHNRKVIAVADDF 752
D+DW + C LG V ++NA+ + ++A D
Sbjct: 322 LDVDWQNNMTFASCSTDMCIHVCRLGCD-HPVKTFQGHTNEVNAIKWDPSGMLLASCSDD 380
Query: 753 CKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFT--------HNDSHLISTGGKDMSIIQW 804
+ ++ K A H AHS + + ++ N S ++++ D ++ W
Sbjct: 381 MTLKIWS---MKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLW 437
Score = 40.4 bits (93), Expect = 0.008
Identities = 48/261 (18%), Positives = 99/261 (37%), Gaps = 17/261 (6%)
Query: 443 ISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPEREIEVPDQYGTIRAVAE 502
++ + H G +F L + G + G D+ I+WD ++ + P V
Sbjct: 268 LASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQ-QFPFHSAPALDVDW 326
Query: 503 GKADQFLVGTSRNFILRGTFNDGFQIEV-QGHTDELWGLATHPFKDLLLTCAQDRQVCLW 561
F ++ I ++ QGHT+E+ + P LL +C+ D + +W
Sbjct: 327 QNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 386
Query: 562 NSME---------HRLEWTRLVDEPGHCADFHPSGTV-VAIGTHSGRWFVLDAETRDLVS 611
+ + H E + P A +P+ ++ +A + + D E
Sbjct: 387 SMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTH 446
Query: 612 IHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDW 671
E + + +S DG +LA GS D +++++ +S G + I + W
Sbjct: 447 TLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG-----TGGIFEVCW 501
Query: 672 SPDNKYIMSNSGDYEILYWDI 692
+ + +++ D + D+
Sbjct: 502 NARGDKVGASASDGSVCVLDL 522
>gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens]
Length = 797
Score = 53.1 bits (126), Expect = 1e-06
Identities = 83/351 (23%), Positives = 127/351 (36%), Gaps = 58/351 (16%)
Query: 385 LTRKQGIFGKYEKPKF--------VQCLAFLGNGDVL-TGDSGGVMLIWSKTTVEPTPGK 435
L + F K PK+ V+ LAF VL T + +W+ P
Sbjct: 459 LPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKS 518
Query: 436 GPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPEREIEVPDQYG 495
V I +AH G V +L NG GG D I W+ P ++ D Y
Sbjct: 519 ASLDVEPIYT-FRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNM---PSPSVDPYDTY- 573
Query: 496 TIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQD 555
+L GT + GHTD +WGLA K+ LL+C+ D
Sbjct: 574 ------------------EPNVLAGT--------LVGHTDAVWGLAYSGIKNQLLSCSAD 607
Query: 556 RQVCLWNSMEHRLEWTRLVDEPGH----CADF---HPSGTVVAIGTHSGRWFVLDAETRD 608
V LWN E + H DF P+ V + T G + D ET
Sbjct: 608 GTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNT--GSAVIYDLETSQ 665
Query: 609 ---LVSIHTDGNEQLS--VMRYSIDGTF-LAVGSHDNFIYLYVVSENGRKYSRYGRCTGH 662
++S D Q + + R T + + +H++ + ++ G+ H
Sbjct: 666 SLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIH---SMVAH 722
Query: 663 SSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTY 713
+T L P+ Y+MS S D I W++ + + + K +D + Y
Sbjct: 723 LDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIY 773
>gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens]
Length = 713
Score = 53.1 bits (126), Expect = 1e-06
Identities = 83/351 (23%), Positives = 127/351 (36%), Gaps = 58/351 (16%)
Query: 385 LTRKQGIFGKYEKPKF--------VQCLAFLGNGDVL-TGDSGGVMLIWSKTTVEPTPGK 435
L + F K PK+ V+ LAF VL T + +W+ P
Sbjct: 375 LPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKS 434
Query: 436 GPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPEREIEVPDQYG 495
V I +AH G V +L NG GG D I W+ P ++ D Y
Sbjct: 435 ASLDVEPIYT-FRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNM---PSPSVDPYDTY- 489
Query: 496 TIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQD 555
+L GT + GHTD +WGLA K+ LL+C+ D
Sbjct: 490 ------------------EPNVLAGT--------LVGHTDAVWGLAYSGIKNQLLSCSAD 523
Query: 556 RQVCLWNSMEHRLEWTRLVDEPGH----CADF---HPSGTVVAIGTHSGRWFVLDAETRD 608
V LWN E + H DF P+ V + T G + D ET
Sbjct: 524 GTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNT--GSAVIYDLETSQ 581
Query: 609 ---LVSIHTDGNEQLS--VMRYSIDGTF-LAVGSHDNFIYLYVVSENGRKYSRYGRCTGH 662
++S D Q + + R T + + +H++ + ++ G+ H
Sbjct: 582 SLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIH---SMVAH 638
Query: 663 SSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTY 713
+T L P+ Y+MS S D I W++ + + + K +D + Y
Sbjct: 639 LDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIY 689
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,119,079
Number of Sequences: 37866
Number of extensions: 1858727
Number of successful extensions: 10949
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 121
Number of HSP's successfully gapped in prelim test: 266
Number of HSP's that attempted gapping in prelim test: 8872
Number of HSP's gapped (non-prelim): 1899
length of query: 923
length of database: 18,247,518
effective HSP length: 112
effective length of query: 811
effective length of database: 14,006,526
effective search space: 11359292586
effective search space used: 11359292586
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.