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Search of human proteins with 114205399
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|114205399 cyclic nucleotide gated channel beta 1 isoform a
[Homo sapiens]
(1251 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H... 2538 0.0
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens] 725 0.0
gi|208431781 cyclic nucleotide gated channel beta 1 isoform b [H... 597 e-170
gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [... 315 1e-85
gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho... 315 1e-85
gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [... 313 9e-85
gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H... 313 9e-85
gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens] 294 4e-79
gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens] 267 4e-71
gi|156071470 hyperpolarization activated cyclic nucleotide-gated... 157 5e-38
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p... 156 1e-37
gi|116325989 hyperpolarization activated cyclic nucleotide-gated... 156 1e-37
gi|38327037 hyperpolarization activated cyclic nucleotide-gated ... 151 4e-36
gi|4504831 potassium voltage-gated channel, subfamily H, member ... 113 1e-24
gi|6912446 potassium voltage-gated channel, subfamily H, member ... 112 3e-24
gi|22024390 potassium voltage-gated channel, subfamily H, member... 108 2e-23
gi|27886648 potassium voltage-gated channel, subfamily H, member... 108 2e-23
gi|27437001 potassium voltage-gated channel, subfamily H, member... 102 2e-21
gi|27886646 potassium voltage-gated channel, subfamily H, member... 99 2e-20
gi|26051273 voltage-gated potassium channel, subfamily H, member... 98 4e-20
gi|4557729 voltage-gated potassium channel, subfamily H, member ... 98 4e-20
gi|27886667 potassium voltage-gated channel, subfamily H, member... 97 7e-20
gi|27886653 potassium voltage-gated channel, subfamily H, member... 96 2e-19
gi|13540549 potassium voltage-gated channel, subfamily H, member... 94 1e-18
gi|38569493 potassium voltage-gated channel, subfamily H (eag-re... 90 1e-17
gi|26051271 voltage-gated potassium channel, subfamily H, member... 85 4e-16
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 85 4e-16
gi|27886651 potassium voltage-gated channel, subfamily H, member... 85 4e-16
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 80 9e-15
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 80 9e-15
>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
sapiens]
Length = 1251
Score = 2538 bits (6577), Expect = 0.0
Identities = 1251/1251 (100%), Positives = 1251/1251 (100%)
Query: 1 MLGWVQRVLPQPPGTPRKTKMQEEEEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFK 60
MLGWVQRVLPQPPGTPRKTKMQEEEEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFK
Sbjct: 1 MLGWVQRVLPQPPGTPRKTKMQEEEEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFK 60
Query: 61 EEEVAVADPSPQETKEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHS 120
EEEVAVADPSPQETKEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHS
Sbjct: 61 EEEVAVADPSPQETKEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHS 120
Query: 121 ITEDPAQILGHGSTGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVW 180
ITEDPAQILGHGSTGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVW
Sbjct: 121 ITEDPAQILGHGSTGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVW 180
Query: 181 RDEPAVATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQ 240
RDEPAVATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQ
Sbjct: 181 RDEPAVATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQ 240
Query: 241 AQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTISILPGGQV 300
AQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTISILPGGQV
Sbjct: 241 AQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTISILPGGQV 300
Query: 301 EPDLVLEEVEPPWEDAHQDVSTSPQGTEVVPAYEEENKAVEKMPRELSRIEEEKEDEEEE 360
EPDLVLEEVEPPWEDAHQDVSTSPQGTEVVPAYEEENKAVEKMPRELSRIEEEKEDEEEE
Sbjct: 301 EPDLVLEEVEPPWEDAHQDVSTSPQGTEVVPAYEEENKAVEKMPRELSRIEEEKEDEEEE 360
Query: 361 EEEEEEEEEEEVTEVLLDSCVVSQVGVGQSEEDGTRPQSTSDQKLWEEVGEEAKKEAEEK 420
EEEEEEEEEEEVTEVLLDSCVVSQVGVGQSEEDGTRPQSTSDQKLWEEVGEEAKKEAEEK
Sbjct: 361 EEEEEEEEEEEVTEVLLDSCVVSQVGVGQSEEDGTRPQSTSDQKLWEEVGEEAKKEAEEK 420
Query: 421 AKEEAEEVAEEEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCPLM 480
AKEEAEEVAEEEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCPLM
Sbjct: 421 AKEEAEEVAEEEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCPLM 480
Query: 481 AEENPPSTVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESPVVAWSD 540
AEENPPSTVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESPVVAWSD
Sbjct: 481 AEENPPSTVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESPVVAWSD 540
Query: 541 PTTPKDTDGQDRAASTASTNSAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKP 600
PTTPKDTDGQDRAASTASTNSAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKP
Sbjct: 541 PTTPKDTDGQDRAASTASTNSAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKP 600
Query: 601 SPAKKAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKYQFPQSIDPLTNLMYVLWL 660
SPAKKAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKYQFPQSIDPLTNLMYVLWL
Sbjct: 601 SPAKKAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKYQFPQSIDPLTNLMYVLWL 660
Query: 661 FFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVRGGD 720
FFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVRGGD
Sbjct: 661 FFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVRGGD 720
Query: 721 IITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVNPLLRLPRCLKYMAFFEFNSRLE 780
IITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVNPLLRLPRCLKYMAFFEFNSRLE
Sbjct: 721 IITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVNPLLRLPRCLKYMAFFEFNSRLE 780
Query: 781 SILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVGNSYIRCYYFAV 840
SILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVGNSYIRCYYFAV
Sbjct: 781 SILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVGNSYIRCYYFAV 840
Query: 841 KTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDST 900
KTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDST
Sbjct: 841 KTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDST 900
Query: 901 VKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKV 960
VKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKV
Sbjct: 901 VKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKV 960
Query: 961 ALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLV 1020
ALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLV
Sbjct: 961 ALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLV 1020
Query: 1021 TLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKA 1080
TLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKA
Sbjct: 1021 TLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKA 1080
Query: 1081 RRMLRSNNKPKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARLKELA 1140
RRMLRSNNKPKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARLKELA
Sbjct: 1081 RRMLRSNNKPKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARLKELA 1140
Query: 1141 ALEAAAKQQELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSP 1200
ALEAAAKQQELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSP
Sbjct: 1141 ALEAAAKQQELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSP 1200
Query: 1201 PPASLGRPEGEEEGPAEPEEHSVRICMSPGPEPGEQILSVKMPEEREEKAE 1251
PPASLGRPEGEEEGPAEPEEHSVRICMSPGPEPGEQILSVKMPEEREEKAE
Sbjct: 1201 PPASLGRPEGEEEGPAEPEEHSVRICMSPGPEPGEQILSVKMPEEREEKAE 1251
>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
Length = 809
Score = 725 bits (1871), Expect = 0.0
Identities = 399/858 (46%), Positives = 522/858 (60%), Gaps = 80/858 (9%)
Query: 409 VGEEAKKEAEEKAKEEAEEVAEEEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQ 468
+GE + E + EE + + + Q+ E K E E + P T + P
Sbjct: 14 IGENNENEQSSRRNEEGSHPSNQSQQTTAQE--ENKGE---EKSLKTKSTPVTSEEPHTN 68
Query: 469 VEDTDADSCPLMAEENPPS--TVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELK 526
++D ++++N T P P A T VP K+ P+
Sbjct: 69 IQDK-------LSKKNSSGDLTTNPDPQNAAEPTGTVPEQKEMDPGKEGPN--------- 112
Query: 527 ALSPAESPVVAWSDPTTPKDTDGQDRAASTASTNSAIINDRLQELVKLFKERTEKVKEKL 586
SP P A P + D Q L LVK ++RT K+KL
Sbjct: 113 --SPQNKPPAA---PVINEYADAQ-----------------LHNLVKRMRQRTALYKKKL 150
Query: 587 IDPDVTSDEESPKPSPAKKAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKY---- 642
++ D++S E SP+ + P P K ++ +P E HY +L K K P +Y
Sbjct: 151 VEGDLSSPEASPQTAK----PTAVPPVKESDDKPTE--HYYRLLWFKVKKMPLTEYLKRI 204
Query: 643 QFPQSIDPLTNLMYVLWLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIY 702
+ P SID T+ +Y+LWL V +A+NWNC IP+R FPYQT DNIH+WL+ D +CD+IY
Sbjct: 205 KLPNSIDSYTDRLYLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIY 264
Query: 703 FLDITVFQTRLQFVRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVNPLLR 762
D+ Q RLQFVRGGDII D ++R +Y S +F++D+ S++P D YL G NP+ R
Sbjct: 265 LYDMLFIQPRLQFVRGGDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFFGFNPMFR 324
Query: 763 LPRCLKYMAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTH 822
R LKY +FFEFN LESI+ KAY+YRVIRTT YLL+ LH+N+C+YYWAS Y+G+G+T
Sbjct: 325 ANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTR 384
Query: 823 WVYDGVGNSYIRCYYFAVKTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDV 882
WVYDG GN Y+RCYY+AV+TLITIGGLP+P+TLFEIVFQLLN+F+GVF FS +IGQMRDV
Sbjct: 385 WVYDGEGNEYLRCYYWAVRTLITIGGLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDV 444
Query: 883 VGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPD 942
+GAATA Q Y+R+CMD T+ YMN Y IPK VQ RV+TWYEYTW SQ MLDES+L+ LP
Sbjct: 445 IGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPT 504
Query: 943 KMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYII 1002
++L LAIDVN++I+SKV LF+GCD QMI+DML RL+SV+YLP D+VCKKGEIG+EMYII
Sbjct: 505 TVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYII 564
Query: 1003 QAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDL 1062
+ G+VQVLGGPDG VLVTLKAGSVFGEISLLA GGGNRRTANVVAHGF NL LDKK L
Sbjct: 565 KHGEVQVLGGPDGTKVLVTLKAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTL 624
Query: 1063 NEILVHYPESQKLLRKKARRMLRSNNK-----PKEEKSVLILPPRAGTPKLFNAALAMTG 1117
EILVHYP+S+++L KKAR +L+ K P + L+ PP+ TPKLF L TG
Sbjct: 625 QEILVHYPDSERILMKKARVLLKQKAKTAEATPPRKDLALLFPPKEETPKLFKTLLGGTG 684
Query: 1118 KMGGKGAKGGKLAHLRARLKELAALEAAAKQQEL---VEQAKSSQDVKGEEGSAAPDQHT 1174
K ARL +L +AA K++ E+ K ++D + E +
Sbjct: 685 KAS------------LARLLKLKREQAAQKKENSEGGEEEGKENEDKQKENEDKQKENED 732
Query: 1175 HPKEAATDPPAPRTPPEPPGSPP--SSPPPASLGRPEGEEEG--PAEPEEHSVRICMSPG 1230
KE D R P E P P ++ P A P P S+ I M+P
Sbjct: 733 KGKE-NEDKDKGREPEEKPLDRPECTASPIAVEEEPHSVRRTVLPRGTSRQSLIISMAPS 791
Query: 1231 PEPGEQILSVKMPEEREE 1248
E GE++L++++ E+ ++
Sbjct: 792 AEGGEEVLTIEVKEKAKQ 809
Score = 38.1 bits (87), Expect = 0.053
Identities = 31/100 (31%), Positives = 46/100 (46%), Gaps = 10/100 (10%)
Query: 334 EEENKAVEKMPRELSRIEEEKEDEEEEEEEEEEEEEEEVTEVLLDSCVVSQVGVGQSEED 393
EEE K E +E ++E ED+ +E E++++ E E + C S + V +
Sbjct: 710 EEEGKENEDKQKENEDKQKENEDKGKENEDKDKGREPEEKPLDRPECTASPIAVEEEPHS 769
Query: 394 GTR---PQSTSDQKL------WEEVGEEAKK-EAEEKAKE 423
R P+ TS Q L E GEE E +EKAK+
Sbjct: 770 VRRTVLPRGTSRQSLIISMAPSAEGGEEVLTIEVKEKAKQ 809
Score = 35.8 bits (81), Expect = 0.26
Identities = 30/115 (26%), Positives = 49/115 (42%), Gaps = 20/115 (17%)
Query: 398 QSTSDQKLWEEVGEEAKKEAEEKAKEEAEEVAEEEAEKEPQDWAETKEEPEAEAEAASSG 457
+ + +K E GEE KE E+K KE ++ E E + + + + EPE
Sbjct: 697 EQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDKGREPE--------- 747
Query: 458 VPATKQHPEVQVEDTDADSCPLMAEENPPS---TVLPPPSPAKSDTLIVPSSASG 509
E ++ + + P+ EE P S TVLP + +S + + SA G
Sbjct: 748 --------EKPLDRPECTASPIAVEEEPHSVRRTVLPRGTSRQSLIISMAPSAEG 794
>gi|208431781 cyclic nucleotide gated channel beta 1 isoform b [Homo
sapiens]
Length = 299
Score = 597 bits (1538), Expect = e-170
Identities = 293/298 (98%), Positives = 294/298 (98%)
Query: 1 MLGWVQRVLPQPPGTPRKTKMQEEEEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFK 60
MLGWVQRVLPQPPGTPRKTKMQEEEEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFK
Sbjct: 1 MLGWVQRVLPQPPGTPRKTKMQEEEEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFK 60
Query: 61 EEEVAVADPSPQETKEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHS 120
EEEVAVADPSPQETKEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHS
Sbjct: 61 EEEVAVADPSPQETKEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHS 120
Query: 121 ITEDPAQILGHGSTGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVW 180
ITEDPAQILGHGSTGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVW
Sbjct: 121 ITEDPAQILGHGSTGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVW 180
Query: 181 RDEPAVATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQ 240
RDEPAVATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQ
Sbjct: 181 RDEPAVATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQ 240
Query: 241 AQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTISILPGG 298
AQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQT + GG
Sbjct: 241 AQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTRVMGAGG 298
Score = 35.4 bits (80), Expect = 0.34
Identities = 54/235 (22%), Positives = 80/235 (34%), Gaps = 21/235 (8%)
Query: 318 QDVSTSPQGTEVVPAYEEENKAVEKMPRELSRIEEEKEDEEEEEEEEEEEEEEEVTEVLL 377
Q V P GT +EE + VE P + +E E EE E E E EE E
Sbjct: 6 QRVLPQPPGTPRKTKMQEEEE-VEPEPEMEAEVEPEPNPEEAETESESMPPEESFKE--- 61
Query: 378 DSCVVSQVGVGQSEEDGTRPQSTSDQKLWEEVGEEAK----KEAEEKAKEEAEEVAEEEA 433
+V V PQ T + L + A+ E ++ + +
Sbjct: 62 -----EEVAVADPS-----PQETKEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVE 111
Query: 434 EKEPQDWAETKEEPEAEAEAASSGVPATKQHPE--VQVEDTDADSCPLMAEENPPSTVLP 491
+ PQ E+P S+G P ++ +DT L+ E VLP
Sbjct: 112 KVIPQPVHSITEDPAQILGHGSTGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLP 171
Query: 492 PPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESPVVAWSDPTTPKD 546
P + P+ A+G P + E L E+P + P PK+
Sbjct: 172 QPPKSSEVWRDEPAVATGAASDPAPPGRPQ-EMGPKLQARETPSLPTPIPLQPKE 225
Score = 33.1 bits (74), Expect = 1.7
Identities = 53/234 (22%), Positives = 89/234 (38%), Gaps = 25/234 (10%)
Query: 397 PQSTSDQKLWEEVGEEAKKEAE-------EKAKEEAEEVAEEEAEKEPQDWAETKEEPEA 449
P+ T Q+ EEV E + EAE E+A+ E+E + EE+ KE + E
Sbjct: 16 PRKTKMQEE-EEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFKEEEVAVADPSPQET 74
Query: 450 EAEAASSGVPATKQHPEVQVEDTDADSCPLMAEENPPSTVLPPPSPAKSDTLIVPSSASG 509
+ A +S + Q E+ ++ + + + P D + S
Sbjct: 75 KEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHSITEDPAQILGHGS- 133
Query: 510 THRKKLPSEDDEAEELKALSPAESPVVAWSD-------PTTPKDTD--GQDRAASTASTN 560
T E +EA E + P ++ W + P PK ++ + A +T + +
Sbjct: 134 TGDTGCTDEPNEALEAQDTRPG-LRLLLWLEQNLERVLPQPPKSSEVWRDEPAVATGAAS 192
Query: 561 SAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKPSPAKKAPEPAPDTK 614
R QE+ + R L P +E PK +P APEP P ++
Sbjct: 193 DPAPPGRPQEMGPKLQARE---TPSLPTPIPLQPKEEPKEAP---APEPQPGSQ 240
Score = 32.3 bits (72), Expect = 2.9
Identities = 28/104 (26%), Positives = 40/104 (38%), Gaps = 24/104 (23%)
Query: 1149 QELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPE-----PPGSPPSSPPPA 1203
+ ++ Q S +V +E + A AA+DP P P E PS P P
Sbjct: 167 ERVLPQPPKSSEVWRDEPAVATG-------AASDPAPPGRPQEMGPKLQARETPSLPTPI 219
Query: 1204 SLGRPEGEEEGPAEPEEHSVRICMSPGPEPGEQILSVKMPEERE 1247
L E +E PA P P+PG Q + +P R+
Sbjct: 220 PLQPKEEPKEAPA------------PEPQPGSQAQTSSLPPTRD 251
>gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [Homo
sapiens]
Length = 676
Score = 315 bits (808), Expect = 1e-85
Identities = 165/458 (36%), Positives = 272/458 (59%), Gaps = 15/458 (3%)
Query: 648 IDPLTNLMYVLWLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDIT 707
+DP +NL Y WL + + +N +L+ R F + + WL++DY D++Y LD+
Sbjct: 143 VDPSSNLYY-RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVL 201
Query: 708 VFQTRLQFVRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVN-PLLRLPRC 766
V + R F+ G +++D + +Y + +FK+D+LSL+P D YLKVG N P +R R
Sbjct: 202 V-RARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRL 260
Query: 767 LKYMAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYD 826
LK+ FEF R E+ + ++R+ Y+L +H N+C+Y+ S + G G+ WVY
Sbjct: 261 LKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYP 320
Query: 827 GVG--------NSYIRCYYFAVKTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQ 878
+ YI Y++ TL TIG P P E +F ++++ GV F+ ++G
Sbjct: 321 NISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGN 380
Query: 879 MRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMV 938
+ ++ A + +++ +DS +YM F K+ K ++ RV W++Y W ++ +DE E++
Sbjct: 381 VGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLK 440
Query: 939 QLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGRE 998
LPDK++ ++AI+V+ + + KV +FQ C+ ++ +++ +LR V+ P DY+CKKG+IG+E
Sbjct: 441 SLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKE 500
Query: 999 MYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGG---GNRRTANVVAHGFTNLF 1055
MYII G++ V+ DG + V L GS FGEIS+L + G GNRRTAN+ + G+++LF
Sbjct: 501 MYIINEGKLAVV-ADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLF 559
Query: 1056 ILDKKDLNEILVHYPESQKLLRKKARRMLRSNNKPKEE 1093
L K DL E L YPE++K L +K R++L +N EE
Sbjct: 560 CLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEE 597
>gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo
sapiens]
Length = 694
Score = 315 bits (808), Expect = 1e-85
Identities = 165/458 (36%), Positives = 272/458 (59%), Gaps = 15/458 (3%)
Query: 648 IDPLTNLMYVLWLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDIT 707
+DP +NL Y WL + + +N +L+ R F + + WL++DY D++Y LD+
Sbjct: 161 VDPSSNLYY-RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVL 219
Query: 708 VFQTRLQFVRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVN-PLLRLPRC 766
V + R F+ G +++D + +Y + +FK+D+LSL+P D YLKVG N P +R R
Sbjct: 220 V-RARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRL 278
Query: 767 LKYMAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYD 826
LK+ FEF R E+ + ++R+ Y+L +H N+C+Y+ S + G G+ WVY
Sbjct: 279 LKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYP 338
Query: 827 GVG--------NSYIRCYYFAVKTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQ 878
+ YI Y++ TL TIG P P E +F ++++ GV F+ ++G
Sbjct: 339 NISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGN 398
Query: 879 MRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMV 938
+ ++ A + +++ +DS +YM F K+ K ++ RV W++Y W ++ +DE E++
Sbjct: 399 VGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLK 458
Query: 939 QLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGRE 998
LPDK++ ++AI+V+ + + KV +FQ C+ ++ +++ +LR V+ P DY+CKKG+IG+E
Sbjct: 459 SLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKE 518
Query: 999 MYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGG---GNRRTANVVAHGFTNLF 1055
MYII G++ V+ DG + V L GS FGEIS+L + G GNRRTAN+ + G+++LF
Sbjct: 519 MYIINEGKLAVV-ADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLF 577
Query: 1056 ILDKKDLNEILVHYPESQKLLRKKARRMLRSNNKPKEE 1093
L K DL E L YPE++K L +K R++L +N EE
Sbjct: 578 CLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEE 615
>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [Homo
sapiens]
Length = 759
Score = 313 bits (801), Expect = 9e-85
Identities = 181/580 (31%), Positives = 311/580 (53%), Gaps = 31/580 (5%)
Query: 517 SEDDEAEELKALSPAESPVVAWSDPTTPKDTDGQDRAASTASTNSAIINDRLQELVKLFK 576
SEDD++ S E+P S G + A+ N + +
Sbjct: 112 SEDDDSASTSEESENENPHARGSFSYKSLRKGGPSQREQYLPGAIALFN--VNNSSNKDQ 169
Query: 577 ERTEKVKEKLIDPDVTSDEESPKPSPAKKAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKH 636
E EK K+K + D+ K P KK + + K E K K
Sbjct: 170 EPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEE--------------KSKD 215
Query: 637 RPWKKYQFPQSIDPLTNLMYVLWLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDY 696
+ ++ + IDP N Y WLF + + +N ++ R F D + +WL++DY
Sbjct: 216 KKEEEKKEVVVIDPSGNTYYN-WLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDY 274
Query: 697 LCDLIYFLDITVFQTRLQFVRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVG 756
+ D++Y +D+ V +TR ++ G ++ ++ + N Y + +FK+D+LSL+P D LY K+G
Sbjct: 275 VSDIVYLIDMFV-RTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLG 333
Query: 757 VN-PLLRLPRCLKYMAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAY 815
N P +RL R L++ FEF R E+ + ++R+ Y++ +H N+C++Y S
Sbjct: 334 WNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKA 393
Query: 816 QGLGSTHWVYDGVGN--------SYIRCYYFAVKTLITIGGLPDPKTLFEIVFQLLNYFT 867
G G+ WVY + + Y+ Y++ TL TIG P P E VF ++++
Sbjct: 394 IGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLI 453
Query: 868 GVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHS 927
GV F+ ++G + ++ A + +++ +D+ +YM+F + K ++ RV W++Y W +
Sbjct: 454 GVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTN 513
Query: 928 QGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPND 987
+ +DE E++ LPDK+R ++AI+V+ + + KV +F C+ ++ +++ +L+ VY P D
Sbjct: 514 KKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGD 573
Query: 988 YVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGG---GNRRTA 1044
Y+CKKG+IGREMYII+ G++ V+ DG + V L GS FGEIS+L + G GNRRTA
Sbjct: 574 YICKKGDIGREMYIIKEGKLAVV-ADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTA 632
Query: 1045 NVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKARRML 1084
N+ + G+++LF L K DL E L YP+++ +L +K +++L
Sbjct: 633 NIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQIL 672
>gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo
sapiens]
Length = 690
Score = 313 bits (801), Expect = 9e-85
Identities = 181/580 (31%), Positives = 311/580 (53%), Gaps = 31/580 (5%)
Query: 517 SEDDEAEELKALSPAESPVVAWSDPTTPKDTDGQDRAASTASTNSAIINDRLQELVKLFK 576
SEDD++ S E+P S G + A+ N + +
Sbjct: 43 SEDDDSASTSEESENENPHARGSFSYKSLRKGGPSQREQYLPGAIALFN--VNNSSNKDQ 100
Query: 577 ERTEKVKEKLIDPDVTSDEESPKPSPAKKAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKH 636
E EK K+K + D+ K P KK + + K E K K
Sbjct: 101 EPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEE--------------KSKD 146
Query: 637 RPWKKYQFPQSIDPLTNLMYVLWLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDY 696
+ ++ + IDP N Y WLF + + +N ++ R F D + +WL++DY
Sbjct: 147 KKEEEKKEVVVIDPSGNTYYN-WLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDY 205
Query: 697 LCDLIYFLDITVFQTRLQFVRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVG 756
+ D++Y +D+ V +TR ++ G ++ ++ + N Y + +FK+D+LSL+P D LY K+G
Sbjct: 206 VSDIVYLIDMFV-RTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLG 264
Query: 757 VN-PLLRLPRCLKYMAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAY 815
N P +RL R L++ FEF R E+ + ++R+ Y++ +H N+C++Y S
Sbjct: 265 WNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKA 324
Query: 816 QGLGSTHWVYDGVGN--------SYIRCYYFAVKTLITIGGLPDPKTLFEIVFQLLNYFT 867
G G+ WVY + + Y+ Y++ TL TIG P P E VF ++++
Sbjct: 325 IGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLI 384
Query: 868 GVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHS 927
GV F+ ++G + ++ A + +++ +D+ +YM+F + K ++ RV W++Y W +
Sbjct: 385 GVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTN 444
Query: 928 QGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPND 987
+ +DE E++ LPDK+R ++AI+V+ + + KV +F C+ ++ +++ +L+ VY P D
Sbjct: 445 KKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGD 504
Query: 988 YVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGG---GNRRTA 1044
Y+CKKG+IGREMYII+ G++ V+ DG + V L GS FGEIS+L + G GNRRTA
Sbjct: 505 YICKKGDIGREMYIIKEGKLAVV-ADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTA 563
Query: 1045 NVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKARRML 1084
N+ + G+++LF L K DL E L YP+++ +L +K +++L
Sbjct: 564 NIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQIL 603
>gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]
Length = 664
Score = 294 bits (752), Expect = 4e-79
Identities = 149/441 (33%), Positives = 256/441 (58%), Gaps = 14/441 (3%)
Query: 656 YVLWLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQF 715
Y WLF + M +N L+ R F WL++DY+ D++Y D+ + + R F
Sbjct: 140 YYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFI-RLRTGF 198
Query: 716 VRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVN-PLLRLPRCLKYMAFFE 774
+ G ++ D K +R+NY+ + +FK+D+ S++P D +Y V ++ P +R R L + FE
Sbjct: 199 LEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPEVRFNRLLHFARMFE 258
Query: 775 FNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGV------ 828
F R E+ + ++R+ Y+L +H N+C+YY S G G WVY +
Sbjct: 259 FFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSIGFGVDTWVYPNITDPEYG 318
Query: 829 --GNSYIRCYYFAVKTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAA 886
YI C Y++ TL TIG P P E +F + ++ GV F+ ++G + ++
Sbjct: 319 YLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNM 378
Query: 887 TAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRL 946
A + +++ +D+ YM F K+ K ++ +V W++Y W ++ +DE E++ LP K+R
Sbjct: 379 NATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRA 438
Query: 947 DLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQ 1006
++AI+V+ + + KV +F C+ ++ +++ +LR V+ P DY+C+KG+IG+EMYII+ G+
Sbjct: 439 EIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGK 498
Query: 1007 VQVLGGPDGKSVLVTLKAGSVFGEISLLAVGG---GNRRTANVVAHGFTNLFILDKKDLN 1063
+ V+ DG + L AGS FGEIS+L + G GNRRTAN+ + G+++LF L K DL
Sbjct: 499 LAVV-ADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLM 557
Query: 1064 EILVHYPESQKLLRKKARRML 1084
E + YP+++K+L ++ R +L
Sbjct: 558 EAVTEYPDAKKVLEERGREIL 578
>gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]
Length = 575
Score = 267 bits (683), Expect = 4e-71
Identities = 165/553 (29%), Positives = 280/553 (50%), Gaps = 24/553 (4%)
Query: 656 YVLWLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQF 715
Y WL +V +N ++ R FP + WL++DY DL+Y LD+ V + F
Sbjct: 34 YYWWLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWLVLDYTSDLLYLLDMVV-RFHTGF 92
Query: 716 VRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVN-PLLRLPRCLKYMAFFE 774
+ G ++ DK + + Y+++ F +DL SL+P D +Y+++G + P LRL R L+ FE
Sbjct: 93 LEQGILVVDKGRISSRYVRTWSFFLDLASLMPTDVVYVRLGPHTPTLRLNRFLRAPRLFE 152
Query: 775 FNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVY--------D 826
R E+ + +R+ + Y+ +H NSCLY+ S Y G G WVY +
Sbjct: 153 AFDRTETRTAYPNAFRIAKLMLYIFVVIHWNSCLYFALSRYLGFGRDAWVYPDPAQPGFE 212
Query: 827 GVGNSYIRCYYFAVKTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAA 886
+ Y+ +YF+ L T+G P P E +F + ++ V F+ ++G M V+
Sbjct: 213 RLRRQYLYSFYFSTLILTTVGDTPPPAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNM 272
Query: 887 TAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRL 946
+ KYM + + ++ RV WY++ ++ M +E ++ LP+++R
Sbjct: 273 NTADAAFYPDHALVKKYMKLQHVNRKLERRVIDWYQHLQINKKMTNEVAILQHLPERLRA 332
Query: 947 DLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQ 1006
++A+ V+ + +S+V +FQ C+ ++ +++ +L+ Y P +YVC+KG+IG+EMYII+ GQ
Sbjct: 333 EVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQ 392
Query: 1007 VQVLGGPDGKSVLVTLKAGSVFGEISLLAVGG---GNRRTANVVAHGFTNLFILDKKDLN 1063
+ V+ DG + L AG FGEIS++ + G GNRRTAN+ + G+++LF L K+DL
Sbjct: 393 LAVV-ADDGITQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLR 451
Query: 1064 EILVHYPESQKLLRKKARRMLRSNNKPKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKG 1123
E+L YP++Q ++ +K R +L NK + + T +
Sbjct: 452 EVLSEYPQAQTIMEEKGREILLKMNKLDVNAEAAEIALQEATESRLRGLDQQLDDL---- 507
Query: 1124 AKGGKLAHLRARLKELAALEAAAKQQELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDP 1183
K A L A L E +AL+ A + + L Q +++ E A D P+E +
Sbjct: 508 --QTKFARLLAEL-ESSALKIAYRIERLEWQ---TREWPMPEDLAEADDEGEPEEGTSKD 561
Query: 1184 PAPRTPPEPPGSP 1196
R E P P
Sbjct: 562 EEGRASQEGPPGP 574
>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
potassium channel 2 [Homo sapiens]
Length = 889
Score = 157 bits (398), Expect = 5e-38
Identities = 145/613 (23%), Positives = 266/613 (43%), Gaps = 70/613 (11%)
Query: 659 WLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITV-FQTRLQFVR 717
W F +++ N +IPV + + W++ + + D + +D+ + F+T +
Sbjct: 214 WDFTMLLFMVGNLIIIPV--GITFFKDETTAPWIVFNVVSDTFFLMDLVLNFRTGIVIED 271
Query: 718 GGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKV--GVNP---------------- 759
+II D + ++ YL++ F +D +S +P+D+++L V G++
Sbjct: 272 NTEIILDPEKIKKKYLRTW-FVVDFVSSIPVDYIFLIVEKGIDSEVYKTARALRIVRFTK 330
Query: 760 ------LLRLPRCLKYMAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWAS 813
LLRL R ++Y+ +E + L+ A V R+ + +L H + CL +
Sbjct: 331 ILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASA-VMRICNLISMMLLLCHWDGCLQFLVP 389
Query: 814 AYQGLGSTHWVYDG--VGNSYIRCYYFAV----KTLITIG-GLPDPKTLFEIVFQLLNYF 866
Q WV V +S+ Y FA+ ++ IG G P+++ +I +L+
Sbjct: 390 MLQDFPRNCWVSINGMVNHSWSELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMI 449
Query: 867 TGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWH 926
G +++ IG ++ + + + Y+ +YM+F+K+P + ++ +YE+ +
Sbjct: 450 VGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQ 509
Query: 927 SQGMLDESELMVQLPDKMRLDLAIDVNYN---IVSKVALFQGCDRQMIFDMLKRLRSVVY 983
+ M DE ++ +L +R ++ VN+N +V+ + LF D + ML +L+ V+
Sbjct: 510 GK-MFDEDSILGELNGPLREEI---VNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVF 565
Query: 984 LPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGGGNRRT 1043
P DY+ ++G IG++MY IQ G V VL + + + L GS FGEI LL G RRT
Sbjct: 566 QPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKE---MKLSDGSYFGEICLLTRG---RRT 619
Query: 1044 ANVVAHGFTNLFILDKKDLNEILVHYP------------------ESQKLLRKKARRMLR 1085
A+V A + L+ L + NE+L YP + +L K + L
Sbjct: 620 ASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLHKVQHDLN 679
Query: 1086 SNNKPKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARLKELAALEAA 1145
S +E +++ + + A L + ++ A L++ AA+
Sbjct: 680 SGVFNNQENAIIQEIVKYDREMVQQAELGQRVGLFPPPPPPPQVTSAIATLQQAAAMSFC 739
Query: 1146 AKQQELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSPPPASL 1205
++ + P P A+ PP P +PP P SP +
Sbjct: 740 ---PQVARPLVGPLALGSPRLVRRPPPGPAPAAASPGPPPPASPPGAPASPRAPRTSPYG 796
Query: 1206 GRPEGEEEGPAEP 1218
G P GPA P
Sbjct: 797 GLPAAPLAGPALP 809
Score = 39.3 bits (90), Expect = 0.024
Identities = 18/49 (36%), Positives = 22/49 (44%)
Query: 1166 GSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSPPPASLGRPEGEEEG 1214
G P P++ PP P PP P +PP PP A PE +EG
Sbjct: 21 GPPPPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAEALPPEAADEG 69
Score = 37.0 bits (84), Expect = 0.12
Identities = 20/46 (43%), Positives = 23/46 (50%), Gaps = 4/46 (8%)
Query: 1176 PKEAATDPPAPRTPPEPPGSPPSS--PPPASLGRPEGEEEGPAEPE 1219
P E+ PAP PP PP +PP PPP P G GPA P+
Sbjct: 10 PGESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPPPG--PGPAPPQ 53
Score = 34.7 bits (78), Expect = 0.59
Identities = 20/55 (36%), Positives = 22/55 (40%), Gaps = 1/55 (1%)
Query: 1163 GEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSPPPASLGRPEGEEEGPAE 1217
GE A P P PP + PP PP +PP P PA P E P E
Sbjct: 11 GESPGATPAPGPPPPPPPA-PPQQQPPPPPPPAPPPGPGPAPPQHPPRAEALPPE 64
Score = 33.1 bits (74), Expect = 1.7
Identities = 20/56 (35%), Positives = 23/56 (41%), Gaps = 5/56 (8%)
Query: 198 GRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPG-----SQAQTSSLPP 248
GRP E A P P P P Q + P PAP P PG + +LPP
Sbjct: 8 GRPGESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAEALPP 63
Score = 31.6 bits (70), Expect = 5.0
Identities = 18/63 (28%), Positives = 22/63 (34%), Gaps = 2/63 (3%)
Query: 1160 DVKGEEGSAAPDQHTHPKEAATDPPAPRTPPE--PPGSPPSSPPPASLGRPEGEEEGPAE 1217
D +G G P PP P P + PP PP+ PP P+ A
Sbjct: 2 DARGGGGRPGESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAEAL 61
Query: 1218 PEE 1220
P E
Sbjct: 62 PPE 64
>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
potassium channel 4 [Homo sapiens]
Length = 1203
Score = 156 bits (394), Expect = 1e-37
Identities = 118/449 (26%), Positives = 211/449 (46%), Gaps = 53/449 (11%)
Query: 659 WLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITV-FQTRLQFVR 717
W +++ N +IPV + +N W++ + + D + +D+ + F+T +
Sbjct: 265 WDLTMLLLMVGNLIIIPV--GITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVED 322
Query: 718 GGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVN------------------- 758
+II D + ++ YLKS F +D +S +P+D+++L V
Sbjct: 323 NTEIILDPQRIKMKYLKSW-FMVDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTK 381
Query: 759 -----PLLRLPRCLKYMAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWAS 813
LLRL R ++Y+ +E + L+ A V R++ +L H + CL +
Sbjct: 382 ILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVV-RIVNLIGMMLLLCHWDGCLQFLVP 440
Query: 814 AYQGLGSTHWVY------DGVGNSYIRCYYFAVKTLITIG-GLPDPKTLFEIVFQLLNYF 866
Q WV + G Y + A+ ++ IG G P + ++ +L+
Sbjct: 441 MLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMI 500
Query: 867 TGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWH 926
G +++ IG ++ + + + Y+ +YM+F+K+P + R+ +YE+ +
Sbjct: 501 VGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQ 560
Query: 927 SQGMLDESELMVQLPDKMRLDLAIDVNYN---IVSKVALFQGCDRQMIFDMLKRLRSVVY 983
+ M DE ++ +L + +R ++ +N+N +V+ + LF D + ML +LR V+
Sbjct: 561 GK-MFDEESILGELSEPLREEI---INFNCRKLVASMPLFANADPNFVTSMLTKLRFEVF 616
Query: 984 LPNDYVCKKGEIGREMYIIQAGQVQVL--GGPDGKSVLVTLKAGSVFGEISLLAVGGGNR 1041
P DY+ ++G IG++MY IQ G V VL G + K L GS FGEI LL G R
Sbjct: 617 QPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETK-----LADGSYFGEICLLTRG---R 668
Query: 1042 RTANVVAHGFTNLFILDKKDLNEILVHYP 1070
RTA+V A + L+ L + NE+L YP
Sbjct: 669 RTASVRADTYCRLYSLSVDNFNEVLEEYP 697
Score = 38.5 bits (88), Expect = 0.041
Identities = 38/137 (27%), Positives = 53/137 (38%), Gaps = 14/137 (10%)
Query: 1101 PRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARLKELAALEAAAKQQELVEQAKSSQD 1160
P A TP AA + G A GG L+ + L L L+ A+ + + + +
Sbjct: 890 PSAPTPSAGVAATTIAGFGHFHKALGGSLSSSDSPL--LTPLQPGARSPQAAQPSPAPPG 947
Query: 1161 VKGEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSPPPASLGRPEG----EEEGPA 1216
+G G P+ P PP+ R+P PG P SLG G E P
Sbjct: 948 ARG--GLGLPEHFLPP------PPSSRSPSSSPGQLGQPPGELSLGLATGPLSTPETPPR 999
Query: 1217 EPEEHSVRICMSPGPEP 1233
+PE S+ S G P
Sbjct: 1000 QPEPPSLVAGASGGASP 1016
Score = 36.6 bits (83), Expect = 0.15
Identities = 35/136 (25%), Positives = 50/136 (36%), Gaps = 26/136 (19%)
Query: 1104 GTPKLFNAALAMTGKMGG-KGAKGGKLAHLRARLKELAALEAAAKQQELVEQAKSSQDVK 1162
G + F +LA G GG G G +H L +A+++ L+
Sbjct: 91 GDCRRFRGSLASLGSRGGGSGGTGSGSSH--------GHLHDSAEERRLIA--------- 133
Query: 1163 GEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSPPPASLGRPEGEEEGPAEPEEHS 1222
EG A+P + P A +P P +P SPP PP +P E
Sbjct: 134 --EGDASPGEDRTPPGLAAEPERPGASAQPAASPP--PPQ----QPPQPASASCEQPSVD 185
Query: 1223 VRICMSPGPEPGEQIL 1238
I + G G+QIL
Sbjct: 186 TAIKVEGGAAAGDQIL 201
>gi|116325989 hyperpolarization activated cyclic nucleotide-gated
potassium channel 1 [Homo sapiens]
Length = 890
Score = 156 bits (394), Expect = 1e-37
Identities = 118/447 (26%), Positives = 210/447 (46%), Gaps = 49/447 (10%)
Query: 659 WLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITV-FQTRLQFVR 717
W +++ N +IPV + T W++ + D ++ LD+ + F+T
Sbjct: 145 WDLIMLIMMVGNLVIIPV--GITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNED 202
Query: 718 GGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKV---------------------- 755
+II D K ++ NYLKS F +D +S +P+D+++L V
Sbjct: 203 SSEIILDPKVIKMNYLKSW-FVVDFISSIPVDYIFLIVEKGMDSEVYKTARALRIVRFTK 261
Query: 756 --GVNPLLRLPRCLKYMAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWAS 813
+ LLRL R ++Y+ +E + L+ A V R+ +L H + CL +
Sbjct: 262 ILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVV-RIFNLIGMMLLLCHWDGCLQFLVP 320
Query: 814 AYQGLGSTHWVY------DGVGNSYIRCYYFAVKTLITIG-GLPDPKTLFEIVFQLLNYF 866
Q WV D G Y + A+ ++ IG G P ++ ++ +L+
Sbjct: 321 LLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMI 380
Query: 867 TGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWH 926
G +++ +G ++ + + + Y+ +YM+F+K+P ++ ++ +YE+ +
Sbjct: 381 VGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQ 440
Query: 927 SQGMLDESELMVQLPDKMRLDLAIDVNYN---IVSKVALFQGCDRQMIFDMLKRLRSVVY 983
+ + DE ++ +L D +R ++ VN+N +V+ + LF D + ML +LR V+
Sbjct: 441 GK-IFDEENILNELNDPLREEI---VNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVF 496
Query: 984 LPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGGGNRRT 1043
P DY+ ++G +G++MY IQ G V G S + L GS FGEI LL G RRT
Sbjct: 497 QPGDYIIREGAVGKKMYFIQHG---VAGVITKSSKEMKLTDGSYFGEICLLTKG---RRT 550
Query: 1044 ANVVAHGFTNLFILDKKDLNEILVHYP 1070
A+V A + L+ L + NE+L YP
Sbjct: 551 ASVRADTYCRLYSLSVDNFNEVLEEYP 577
>gi|38327037 hyperpolarization activated cyclic nucleotide-gated
potassium channel 3 [Homo sapiens]
Length = 774
Score = 151 bits (381), Expect = 4e-36
Identities = 119/468 (25%), Positives = 215/468 (45%), Gaps = 50/468 (10%)
Query: 659 WLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITV-FQTRLQFVR 717
W +++ N ++PV F + +N W++ + L D + LD+ + F+T +
Sbjct: 96 WDLIMLLLMVGNLIVLPVGITFFKE--ENSPPWIVFNVLSDTFFLLDLVLNFRTGIVVEE 153
Query: 718 GGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVNP------------------ 759
G +I+ + +R YL++ F +DL+S +P+D+++L V + P
Sbjct: 154 GAEILLAPRAIRTRYLRTW-FLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRIVRF 212
Query: 760 --------LLRLPRCLKYMAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYW 811
LLRL R ++Y+ +E + L+ A V R+ +L H + CL +
Sbjct: 213 TKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVV-RIFNLIGMMLLLCHWDGCLQFL 271
Query: 812 ASAYQG------LGSTHWVYDGVGNSYIRCYYFAVKTLITIG-GLPDPKTLFEIVFQLLN 864
Q + H V G Y + A+ ++ IG G P + ++ +L+
Sbjct: 272 VPMLQDFPPDCWVSINHMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLS 331
Query: 865 YFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYT 924
G +++ IG ++ + + + Y+ +YM+F+K+P + R+ +YE+
Sbjct: 332 MIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHR 391
Query: 925 WHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYL 984
+ + M DE ++ +L + +R ++ +V+ + LF D + +L +LR V+
Sbjct: 392 YQGK-MFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQ 450
Query: 985 PNDYVCKKGEIGREMYIIQAGQVQVL--GGPDGKSVLVTLKAGSVFGEISLLAVGGGNRR 1042
P D V ++G +GR+MY IQ G + VL G D + L GS FGEI LL G RR
Sbjct: 451 PGDLVVREGSVGRKMYFIQHGLLSVLARGARDTR-----LTDGSYFGEICLLTRG---RR 502
Query: 1043 TANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKAR-RMLRSNNK 1089
TA+V A + L+ L N +L +P ++ A R+LR K
Sbjct: 503 TASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGKK 550
>gi|4504831 potassium voltage-gated channel, subfamily H, member 1
isoform 2 [Homo sapiens]
Length = 962
Score = 113 bits (283), Expect = 1e-24
Identities = 117/514 (22%), Positives = 211/514 (41%), Gaps = 82/514 (15%)
Query: 659 WLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVR- 717
W + +++ + L+P +F +T N WL++D + D+I+ +DI V FV
Sbjct: 220 WDWIILILTFYTAILVPYNVSF--KTRQNNVAWLVVDSIVDVIFLVDI-VLNFHTTFVGP 276
Query: 718 GGDIITDKKDMRNNYLKSRRFKMDLLSLLPLD----FLYLKVGVNPLLRLPRCLKYMAFF 773
G++I+D K +R NYLK+ F +DLLS LP D F + G++ L + ++ +
Sbjct: 277 AGEVISDPKLIRMNYLKTW-FVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLG 335
Query: 774 EFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQ----------------- 816
+L+ + V+ + L + H +C++Y Y+
Sbjct: 336 RVARKLDHYIEYGAAVLVLLVCVFGL-AAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQ 394
Query: 817 ------------GLGSTHWVYDGVGNS-YIRCYYFAVKTLITIG-GLPDPKTLFEIVFQL 862
G GS W NS YI YF + +L ++G G P T E +F +
Sbjct: 395 LAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAV 454
Query: 863 LNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYE 922
G ++ + G + + A Y ++S ++ Y++PK + RV +
Sbjct: 455 AIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIV 514
Query: 923 YTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVV 982
TW +D +++ P MR D+ + +N + + F+ + + ++V
Sbjct: 515 STWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVH 574
Query: 983 YLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEI----SLLAVGG 1038
P D + GE + + +G ++V+ V+ L G VFG++ + LA
Sbjct: 575 CAPGDLIYHAGESVDSLCFVVSGSLEVI---QDDEVVAILGKGDVFGDVFWKEATLA--- 628
Query: 1039 GNRRTANVVAHGFTNLFILDKKDLNEILVHYPE-----SQKLL----------------- 1076
+ ANV A + +L ++ + L ++L Y S+ L+
Sbjct: 629 --QSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDV 686
Query: 1077 -RKKARRMLRSNNKPKEEKSVLILPPRAGTPKLF 1109
R++ RM R N P LILPP +LF
Sbjct: 687 KREEEERMKRKNEAP------LILPPDHPVRRLF 714
>gi|6912446 potassium voltage-gated channel, subfamily H, member 4
[Homo sapiens]
Length = 1017
Score = 112 bits (279), Expect = 3e-24
Identities = 143/647 (22%), Positives = 263/647 (40%), Gaps = 85/647 (13%)
Query: 658 LWLFFVVMAWNWNCWLIPVRWAFPYQ--TPDNIHHWLLMDYLCDLIYFLDITVFQTRLQF 715
+W +++A + +P F TP H L+ D ++++ LDI +
Sbjct: 228 IWDGLILLATFYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYV 287
Query: 716 VRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYL-KVGVNPLLRLPRCLKYMAFFE 774
+ G +I+ + + +YL + F +DL++ LP D LY+ + V L+ L + ++ +
Sbjct: 288 SQSGQVISAPRSIGLHYLATWFF-IDLIAALPFDLLYIFNITVTSLVHLLKTVRLLRLLR 346
Query: 775 FNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQ---------GLGSTH--- 822
+LE + V + + + L + H +C++Y + +G H
Sbjct: 347 LLQKLERYSQCSAVVLTLLMSVFALLA-HWMACIWYVIGRREMEANDPLLWDIGWLHELG 405
Query: 823 ------WVYDGVG-----NSYIRCYYFAVKTLITIG-GLPDPKTLFEIVFQLLNYFTGVF 870
+V VG ++YI YF + +L ++G G T E +F + G
Sbjct: 406 KRLEVPYVNGSVGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGAL 465
Query: 871 AFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGM 930
+V+ G + ++ + ++ Y S M ++ +++P+ ++ R+ +++ TW
Sbjct: 466 MHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSG 525
Query: 931 LDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVC 990
+D +EL+ PD++R D+A+ +N I+ ++ LF R + + +++ P +Y+
Sbjct: 526 IDANELLRDFPDELRADIAMHLNREIL-QLPLFGAASRGCLRALSLHIKTSFCAPGEYLL 584
Query: 991 KKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFG--------EISLLAVGGGNRR 1042
++G+ + Y + +G ++VL VL L G + G E L A +
Sbjct: 585 RRGDALQAHYYVCSGSLEVL---RDNMVLAILGKGDLIGADIPEPGQEPGLGADPNFVLK 641
Query: 1043 T-ANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKARRMLRSNNKPKEEKSVL---I 1098
T A+V A + L L + L E+L YPE R R L N + + S L
Sbjct: 642 TSADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAFRAGLPRDLTFNLRQGSDTSGLSRFS 701
Query: 1099 LPPRAGTPK-----------LFNAALAMTGKMGGKG----------------AKGGKLAH 1131
PR P+ L + A +G G G +G ++
Sbjct: 702 RSPRLSQPRSESLGSSSDKTLPSITEAESGAEPGGGPRPRRPLLLPNLSPARPRGSLVSL 761
Query: 1132 LRARLKELAALEAAAKQQELVEQAKSSQDVKGEEGSAAPDQHTHPK-EAATDPPAPRTPP 1190
L L +AL ++ + A + G+ SA+P H P+ AA PP PP
Sbjct: 762 LGEELPPFSALVSSPSLSPSLSPA-----LAGQGHSASP--HGPPRCSAAWKPPQLLIPP 814
Query: 1191 EPPGSPPSSPPPASLGRPEGEEEGPAEPEEHSVRICMSPG-PEPGEQ 1236
PP P +G E+ + E S R P P P Q
Sbjct: 815 LGTFGPPDLSPRI----VDGIEDSGSTAEAPSFRFSRRPELPRPRSQ 857
>gi|22024390 potassium voltage-gated channel, subfamily H, member 5
isoform 1 [Homo sapiens]
Length = 988
Score = 108 bits (271), Expect = 2e-23
Identities = 102/448 (22%), Positives = 190/448 (42%), Gaps = 56/448 (12%)
Query: 667 WNWNCWL------IPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVR-GG 719
W+W + I V + ++T N WL++D + D+I+ +DI V FV GG
Sbjct: 217 WDWVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDI-VLNFHTTFVGPGG 275
Query: 720 DIITDKKDMRNNYLKSRRFKMDLLSLLPLD----FLYLKVGVNPLLRLPRCLKYMAFFEF 775
++I+D K +R NYLK+ F +DLLS LP D F + G++ L + ++ +
Sbjct: 276 EVISDPKLIRMNYLKTW-FVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRV 334
Query: 776 NSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGST-------HWVYD-- 826
+L+ L V+ + L + H +C++Y Y+ + W+Y
Sbjct: 335 ARKLDHYLEYGAAVLVLLVCVFGLVA-HWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLA 393
Query: 827 -GVGNSY-------------------IRCYYFAVKTLITIG-GLPDPKTLFEIVFQLLNY 865
+G Y + YF + +L TIG G P T E +F +
Sbjct: 394 LSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMM 453
Query: 866 FTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTW 925
G ++ + G + + A Y +++ ++ Y++PK + RV + TW
Sbjct: 454 MVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTW 513
Query: 926 HSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLP 985
+D +++ P MR D+ + +N + ++ F+ + + +++ P
Sbjct: 514 SMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAP 573
Query: 986 NDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEI----SLLAVGGGNR 1041
D + GE + + +G ++V+ V+ L G VFG+I + LA
Sbjct: 574 GDLIYHAGESVDALCFVVSGSLEVI---QDDEVVAILGKGDVFGDIFWKETTLA-----H 625
Query: 1042 RTANVVAHGFTNLFILDKKDLNEILVHY 1069
ANV A + +L I+ ++ L ++L Y
Sbjct: 626 ACANVRALTYCDLHIIKREALLKVLDFY 653
>gi|27886648 potassium voltage-gated channel, subfamily H, member 5
isoform 2 [Homo sapiens]
Length = 624
Score = 108 bits (271), Expect = 2e-23
Identities = 102/448 (22%), Positives = 190/448 (42%), Gaps = 56/448 (12%)
Query: 667 WNWNCWL------IPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVR-GG 719
W+W + I V + ++T N WL++D + D+I+ +DI V FV GG
Sbjct: 159 WDWVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDI-VLNFHTTFVGPGG 217
Query: 720 DIITDKKDMRNNYLKSRRFKMDLLSLLPLD----FLYLKVGVNPLLRLPRCLKYMAFFEF 775
++I+D K +R NYLK+ F +DLLS LP D F + G++ L + ++ +
Sbjct: 218 EVISDPKLIRMNYLKTW-FVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRV 276
Query: 776 NSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGST-------HWVYD-- 826
+L+ L V+ + L + H +C++Y Y+ + W+Y
Sbjct: 277 ARKLDHYLEYGAAVLVLLVCVFGLVA-HWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLA 335
Query: 827 -GVGNSY-------------------IRCYYFAVKTLITIG-GLPDPKTLFEIVFQLLNY 865
+G Y + YF + +L TIG G P T E +F +
Sbjct: 336 LSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMM 395
Query: 866 FTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTW 925
G ++ + G + + A Y +++ ++ Y++PK + RV + TW
Sbjct: 396 MVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTW 455
Query: 926 HSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLP 985
+D +++ P MR D+ + +N + ++ F+ + + +++ P
Sbjct: 456 SMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAP 515
Query: 986 NDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEI----SLLAVGGGNR 1041
D + GE + + +G ++V+ V+ L G VFG+I + LA
Sbjct: 516 GDLIYHAGESVDALCFVVSGSLEVI---QDDEVVAILGKGDVFGDIFWKETTLA-----H 567
Query: 1042 RTANVVAHGFTNLFILDKKDLNEILVHY 1069
ANV A + +L I+ ++ L ++L Y
Sbjct: 568 ACANVRALTYCDLHIIKREALLKVLDFY 595
>gi|27437001 potassium voltage-gated channel, subfamily H, member 1
isoform 1 [Homo sapiens]
Length = 989
Score = 102 bits (255), Expect = 2e-21
Identities = 120/540 (22%), Positives = 213/540 (39%), Gaps = 107/540 (19%)
Query: 659 WLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVR- 717
W + +++ + L+P +F +T N WL++D + D+I+ +DI V FV
Sbjct: 220 WDWIILILTFYTAILVPYNVSF--KTRQNNVAWLVVDSIVDVIFLVDI-VLNFHTTFVGP 276
Query: 718 GGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVNPLLRLPRCLKYMAFFEF-- 775
G++I+D K +R NYLK+ F +DLLS LP D + V+ + + F +
Sbjct: 277 AGEVISDPKLIRMNYLKTW-FVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIP 335
Query: 776 -------NSRLESILSKAYVYRVIRTTA-------YLLY--------------SLHLNSC 807
+ + S+ S V R++R Y+ Y + H +C
Sbjct: 336 PPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMAC 395
Query: 808 LYYWASAYQ-----------------------------GLGSTHWVYDGVGNS-YIRCYY 837
++Y Y+ G GS W NS YI Y
Sbjct: 396 IWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLY 455
Query: 838 FAVKTLITIG-GLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSC 896
F + +L ++G G P T E +F + G ++ + G + + A Y
Sbjct: 456 FTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEM 515
Query: 897 MDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNI 956
++S ++ Y++PK + RV + TW +D +++ P MR D+ + +N +
Sbjct: 516 LNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKV 575
Query: 957 VSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGK 1016
+ F+ + + ++V P D + GE + + +G ++V+
Sbjct: 576 FKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVI---QDD 632
Query: 1017 SVLVTLKAGSVFGEI----SLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPE- 1071
V+ L G VFG++ + LA + ANV A + +L ++ + L ++L Y
Sbjct: 633 EVVAILGKGDVFGDVFWKEATLA-----QSCANVRALTYCDLHVIKRDALQKVLEFYTAF 687
Query: 1072 ----SQKLL------------------RKKARRMLRSNNKPKEEKSVLILPPRAGTPKLF 1109
S+ L+ R++ RM R N P LILPP +LF
Sbjct: 688 SHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAP------LILPPDHPVRRLF 741
>gi|27886646 potassium voltage-gated channel, subfamily H, member 5
isoform 3 [Homo sapiens]
Length = 611
Score = 99.4 bits (246), Expect = 2e-20
Identities = 85/394 (21%), Positives = 166/394 (42%), Gaps = 44/394 (11%)
Query: 667 WNWNCWL------IPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVR-GG 719
W+W + I V + ++T N WL++D + D+I+ +DI V FV GG
Sbjct: 217 WDWVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDI-VLNFHTTFVGPGG 275
Query: 720 DIITDKKDMRNNYLKSRRFKMDLLSLLPLD----FLYLKVGVNPLLRLPRCLKYMAFFEF 775
++I+D K +R NYLK+ F +DLLS LP D F + G++ L + ++ +
Sbjct: 276 EVISDPKLIRMNYLKTW-FVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRV 334
Query: 776 NSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGST-------HWVYD-- 826
+L+ L V+ + L + H +C++Y Y+ + W+Y
Sbjct: 335 ARKLDHYLEYGAAVLVLLVCVFGLVA-HWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLA 393
Query: 827 -GVGNSY-------------------IRCYYFAVKTLITIG-GLPDPKTLFEIVFQLLNY 865
+G Y + YF + +L TIG G P T E +F +
Sbjct: 394 LSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMM 453
Query: 866 FTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTW 925
G ++ + G + + A Y +++ ++ Y++PK + RV + TW
Sbjct: 454 MVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTW 513
Query: 926 HSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLP 985
+D +++ P MR D+ + +N + ++ F+ + + +++ P
Sbjct: 514 SMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAP 573
Query: 986 NDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVL 1019
D + GE + + +G ++V+ + ++L
Sbjct: 574 GDLIYHAGESVDALCFVVSGSLEVIQDDEVVAIL 607
>gi|26051273 voltage-gated potassium channel, subfamily H, member 2
isoform c [Homo sapiens]
Length = 819
Score = 98.2 bits (243), Expect = 4e-20
Identities = 80/404 (19%), Positives = 185/404 (45%), Gaps = 35/404 (8%)
Query: 693 LMDYLCDLIYFLDITVFQTRLQFVRGGD-IITDKKDMRNNYLKSRRFKMDLLSLLPLDFL 751
++D + D+++ +DI + R +V + +++ + +Y K F +D+++ +P D L
Sbjct: 114 VVDLIVDIMFIVDILI-NFRTTYVNANEEVVSHPGRIAVHYFKGW-FLIDMVAAIPFDLL 171
Query: 752 YLKVGVNPLLRLPRCLKYMAFFEFNSRLE--SILSKAYVYRVIRTTAYLLYSLHLNSCLY 809
G L+ L + + + +L+ S A ++ ++ T A + + L +C++
Sbjct: 172 IFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWL---ACIW 228
Query: 810 YWASAYQG------LGSTHWVYDGVG--------------NSYIRCYYFAVKTLITIG-G 848
Y + +G H + D +G + Y+ YF +L ++G G
Sbjct: 229 YAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFG 288
Query: 849 LPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYK 908
P T E +F + G ++ + G + ++ +G Y + M +++ F++
Sbjct: 289 NVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQ 348
Query: 909 IPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDR 968
IP ++ R++ ++++ W +D + ++ P+ ++ D+ + +N +++ F+G +
Sbjct: 349 IPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATK 408
Query: 969 QMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVF 1028
+ + + ++ P D + G++ +Y I G +++L G V+ L +F
Sbjct: 409 GCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEIL---RGDVVVAILGKNDIF 465
Query: 1029 GE-ISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPE 1071
GE ++L A G + +V A + +L + + DL E+L YPE
Sbjct: 466 GEPLNLYARPG--KSNGDVRALTYCDLHKIHRDDLLEVLDMYPE 507
>gi|4557729 voltage-gated potassium channel, subfamily H, member 2
isoform a [Homo sapiens]
Length = 1159
Score = 98.2 bits (243), Expect = 4e-20
Identities = 80/404 (19%), Positives = 185/404 (45%), Gaps = 35/404 (8%)
Query: 693 LMDYLCDLIYFLDITVFQTRLQFVRGGD-IITDKKDMRNNYLKSRRFKMDLLSLLPLDFL 751
++D + D+++ +DI + R +V + +++ + +Y K F +D+++ +P D L
Sbjct: 454 VVDLIVDIMFIVDILI-NFRTTYVNANEEVVSHPGRIAVHYFKGW-FLIDMVAAIPFDLL 511
Query: 752 YLKVGVNPLLRLPRCLKYMAFFEFNSRLE--SILSKAYVYRVIRTTAYLLYSLHLNSCLY 809
G L+ L + + + +L+ S A ++ ++ T A + + L +C++
Sbjct: 512 IFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWL---ACIW 568
Query: 810 YWASAYQG------LGSTHWVYDGVG--------------NSYIRCYYFAVKTLITIG-G 848
Y + +G H + D +G + Y+ YF +L ++G G
Sbjct: 569 YAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFG 628
Query: 849 LPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYK 908
P T E +F + G ++ + G + ++ +G Y + M +++ F++
Sbjct: 629 NVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQ 688
Query: 909 IPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDR 968
IP ++ R++ ++++ W +D + ++ P+ ++ D+ + +N +++ F+G +
Sbjct: 689 IPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATK 748
Query: 969 QMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVF 1028
+ + + ++ P D + G++ +Y I G +++L G V+ L +F
Sbjct: 749 GCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEIL---RGDVVVAILGKNDIF 805
Query: 1029 GE-ISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPE 1071
GE ++L A G + +V A + +L + + DL E+L YPE
Sbjct: 806 GEPLNLYARPG--KSNGDVRALTYCDLHKIHRDDLLEVLDMYPE 847
>gi|27886667 potassium voltage-gated channel, subfamily H, member 8
[Homo sapiens]
Length = 1107
Score = 97.4 bits (241), Expect = 7e-20
Identities = 117/621 (18%), Positives = 253/621 (40%), Gaps = 82/621 (13%)
Query: 695 DYLCDLIYFLDITVFQTRLQFVRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLY-L 753
D ++++ +DI + + G +I + + + +Y+ + F +DL++ LP D LY
Sbjct: 261 DIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVTTW-FIIDLIAALPFDLLYAF 319
Query: 754 KVGVNPLLRLPRCLKYMAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYY--- 810
V V L+ L + ++ + +L+ + + + + + L + H +C++Y
Sbjct: 320 NVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLMSMFALLA-HWMACIWYVIG 378
Query: 811 -----------WASAY-----QGLGSTHWVYDGVG-----NSYIRCYYFAVKTLITIG-G 848
W + + L S ++ + +G ++YI YF + +L ++G G
Sbjct: 379 KMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSVGFG 438
Query: 849 LPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYK 908
T E +F + G +++ G + ++ + + Y + ++ +
Sbjct: 439 NVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHH 498
Query: 909 IPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDR 968
+P+ ++ R+ +++ TW +D +EL+ PD++R D+ + +N I+ +++LF+ R
Sbjct: 499 LPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEIL-QLSLFECASR 557
Query: 969 QMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVF 1028
+ + +++ P +Y+ ++G+ + +Y + +G ++VL VL L G +
Sbjct: 558 GCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVL---KDSMVLAILGKGDLI 614
Query: 1029 GEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKARRMLRSNN 1088
G +L + A+V A + +L + K L E+L YPE + + L N
Sbjct: 615 G-ANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHKFVEDIQHDLTYNL 673
Query: 1089 KPKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHL--RARLKELAALEAAA 1146
+ E V+ +L N ++ + G G +L + +E E A
Sbjct: 674 REGHESDVI--------SRLSNKSMVSQSEPKGNGNINKRLPSIVEDEEEEEEGEEEEAV 725
Query: 1147 KQQELVEQAKSSQDVK------------GEEGSAAPDQHTHPKEAATDPPAPRTPPEPPG 1194
+ + SS++ K + S H+ + + ++ P + +PP
Sbjct: 726 SLSPICTRGSSSRNKKVGSNKAYLGLSLKQLASGTVPFHSPIRVSRSNSPKTKQEIDPPN 785
Query: 1195 SPP---------------SSPPPASLGRPEGEEEGPAEPEEH-----SVRICMSP----- 1229
+ PP S +G E+G + E S RI P
Sbjct: 786 HNKRKEKNLKLQLSTLNNAGPPDLSPRIVDGIEDGNSSEESQTFDFGSERIRSEPRISPP 845
Query: 1230 --GPEPGEQILSVKMPEEREE 1248
PE G +L +K E +++
Sbjct: 846 LGDPEIGAAVLFIKAEETKQQ 866
Score = 33.1 bits (74), Expect = 1.7
Identities = 27/92 (29%), Positives = 42/92 (45%), Gaps = 4/92 (4%)
Query: 287 CDVQTISILPGGQVEPDLVLEEVEPPWEDAHQDVSTSPQG---TEVVPAYEEENKAVEKM 343
CD+Q I IL G DL E ED D++ + + ++V+ ++ +
Sbjct: 637 CDLQCI-ILKGLFEVLDLYPEYAHKFVEDIQHDLTYNLREGHESDVISRLSNKSMVSQSE 695
Query: 344 PRELSRIEEEKEDEEEEEEEEEEEEEEEVTEV 375
P+ I + E+EEEEEE EEEE +
Sbjct: 696 PKGNGNINKRLPSIVEDEEEEEEGEEEEAVSL 727
>gi|27886653 potassium voltage-gated channel, subfamily H, member 7
isoform 1 [Homo sapiens]
Length = 1196
Score = 96.3 bits (238), Expect = 2e-19
Identities = 77/404 (19%), Positives = 181/404 (44%), Gaps = 31/404 (7%)
Query: 693 LMDYLCDLIYFLDITVFQTRLQFVRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLY 752
++D + D+++ +DI + + ++++D + +Y K F +D+++ +P D L
Sbjct: 453 VVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGW-FLIDMVAAIPFDLLI 511
Query: 753 LKVGVNP------------LLRLPRCLKYM-AFFEFNSRLESILSKAYVYRVIRTTAYLL 799
G + LLRL R + + + E+ + + +L + + A +
Sbjct: 512 FGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFAL-IAHWLACIW 570
Query: 800 YSL------HLNSCLYYWASAYQGLGSTHWVYDG-----VGNSYIRCYYFAVKTLITIG- 847
Y++ +L + + S Q +G + D + + Y+ YF +L ++G
Sbjct: 571 YAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTSVGF 630
Query: 848 GLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFY 907
G P T E +F + G ++ + G + ++ +G Y M +++ F+
Sbjct: 631 GNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFH 690
Query: 908 KIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCD 967
+IP ++ R++ ++++ W +D + ++ P+ ++ D+ + +N ++ F+G
Sbjct: 691 QIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFRGAS 750
Query: 968 RQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSV 1027
+ + + + ++ P D + G++ +Y + G +++L V+ L +
Sbjct: 751 KGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEIL---KDDIVVAILGKNDI 807
Query: 1028 FGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPE 1071
FGE+ L G + A+V A + +L + ++DL E+L YPE
Sbjct: 808 FGEMVHLYAKPG-KSNADVRALTYCDLHKIQREDLLEVLDMYPE 850
>gi|13540549 potassium voltage-gated channel, subfamily H, member 6
isoform 1 [Homo sapiens]
Length = 994
Score = 93.6 bits (231), Expect = 1e-18
Identities = 83/407 (20%), Positives = 185/407 (45%), Gaps = 39/407 (9%)
Query: 693 LMDYLCDLIYFLDITVFQTRLQFVRGGD-IITDKKDMRNNYLKSRRFKMDLLSLLPLDFL 751
++D + D+++ +DI V R +V D +++ + + +Y K F +D+++ +P D L
Sbjct: 302 VVDLIVDIMFVVDI-VINFRTTYVNTNDEVVSHPRRIAVHYFKGW-FLIDMVAAIPFDLL 359
Query: 752 YLKVG---VNPLLRLPRCLKYMAFFEFNSRLE--SILSKAYVYRVIRTTAYLLYSLHLNS 806
+ G L+ L + + + +L+ S A ++ ++ T A + + L +
Sbjct: 360 IFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWL---A 416
Query: 807 CLYYWASAYQGLGSTH---WV----------YDG--------VGNSYIRCYYFAVKTLIT 845
C++Y + H W+ Y+G V + Y+ YF +L +
Sbjct: 417 CIWYAIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTS 476
Query: 846 IG-GLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYM 904
+G G P T E VF + G ++ + G + ++ +G Y + M +++
Sbjct: 477 VGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFI 536
Query: 905 NFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQ 964
F++IP ++ R++ ++++ W +D + ++ P+ ++ D+ + ++ ++ F
Sbjct: 537 RFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFS 596
Query: 965 GCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKA 1024
G + + + + ++ P D + G++ +Y I G +++L V+ L
Sbjct: 597 GAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEIL---RDDVVVAILGK 653
Query: 1025 GSVFGE-ISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYP 1070
+FGE +SL A G + +A+V A + +L + + DL E+L YP
Sbjct: 654 NDIFGEPVSLHAQPG--KSSADVRALTYCDLHKIQRADLLEVLDMYP 698
>gi|38569493 potassium voltage-gated channel, subfamily H
(eag-related), member 3 [Homo sapiens]
Length = 1083
Score = 90.1 bits (222), Expect = 1e-17
Identities = 93/431 (21%), Positives = 182/431 (42%), Gaps = 62/431 (14%)
Query: 695 DYLCDLIYFLDITVFQTRLQFV-RGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLY- 752
D ++++ LDI V R FV + G ++ K + +Y+ + F +D+++ LP D L+
Sbjct: 265 DLAVEVLFILDI-VLNFRTTFVSKSGQVVFAPKSICLHYVTTW-FLLDVIAALPFDLLHA 322
Query: 753 LKVGVNPLLRLPRCLKYMAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWA 812
KV V L + ++ + RL+ + V + + L + H +C++++
Sbjct: 323 FKVNVYFGAHLLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVFALLA-HWVACVWFYI 381
Query: 813 ------SAYQGLGSTHWVYD-----------------------------------GVG-- 829
S+ L W+ + G G
Sbjct: 382 GQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCSSSSEANGTGLE 441
Query: 830 --------NSYIRCYYFAVKTLITIG-GLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMR 880
++YI YFA+ +L ++G G T E +F + G +V+ G +
Sbjct: 442 LLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNVT 501
Query: 881 DVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQL 940
++ A + Y S Y+ ++IPK ++ R+ +++ TW +D +EL+ L
Sbjct: 502 AIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQSL 561
Query: 941 PDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMY 1000
PD++R D+A+ ++ ++ ++ LF+ R + + LR P +Y+ +G+ + +Y
Sbjct: 562 PDELRADIAMHLHKEVL-QLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQALY 620
Query: 1001 IIQAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKK 1060
+ +G ++VL G +VL L G + G L + A+V + L L
Sbjct: 621 FVCSGSMEVL---KGGTVLAILGKGDLIG-CELPRREQVVKANADVKGLTYCVLQCLQLA 676
Query: 1061 DLNEILVHYPE 1071
L++ L YPE
Sbjct: 677 GLHDSLALYPE 687
Score = 32.0 bits (71), Expect = 3.8
Identities = 27/95 (28%), Positives = 34/95 (35%), Gaps = 10/95 (10%)
Query: 173 PPKSSEVWRDEPAVATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPA 232
P S W A T + SD PP G TP+ P P EE
Sbjct: 980 PASQSSPWPRATAFWT-STSDSEPPAS----GDLCSEPSTPASPPP-----SEEGARTGP 1029
Query: 233 PEPQPGSQAQTSSLPPTRDPARLVAWVLHRLEMAL 267
EP ++A ++ PP + W H LEM L
Sbjct: 1030 AEPVSQAEATSTGEPPPGSGGLALPWDPHSLEMVL 1064
>gi|26051271 voltage-gated potassium channel, subfamily H, member 2
isoform b [Homo sapiens]
Length = 888
Score = 85.1 bits (209), Expect = 4e-16
Identities = 62/344 (18%), Positives = 156/344 (45%), Gaps = 29/344 (8%)
Query: 693 LMDYLCDLIYFLDITVFQTRLQFVRGGD-IITDKKDMRNNYLKSRRFKMDLLSLLPLDFL 751
++D + D+++ +DI + R +V + +++ + +Y K F +D+++ +P D L
Sbjct: 454 VVDLIVDIMFIVDILI-NFRTTYVNANEEVVSHPGRIAVHYFKGW-FLIDMVAAIPFDLL 511
Query: 752 YLKVGVNPLLRLPRCLKYMAFFEFNSRLE--SILSKAYVYRVIRTTAYLLYSLHLNSCLY 809
G L+ L + + + +L+ S A ++ ++ T A + + L +C++
Sbjct: 512 IFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWL---ACIW 568
Query: 810 YWASAYQG------LGSTHWVYDGVG--------------NSYIRCYYFAVKTLITIG-G 848
Y + +G H + D +G + Y+ YF +L ++G G
Sbjct: 569 YAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFG 628
Query: 849 LPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYK 908
P T E +F + G ++ + G + ++ +G Y + M +++ F++
Sbjct: 629 NVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQ 688
Query: 909 IPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDR 968
IP ++ R++ ++++ W +D + ++ P+ ++ D+ + +N +++ F+G +
Sbjct: 689 IPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATK 748
Query: 969 QMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGG 1012
+ + + ++ P D + G++ +Y I G +++L G
Sbjct: 749 GCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRG 792
>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
sapiens]
Length = 1130
Score = 85.1 bits (209), Expect = 4e-16
Identities = 93/353 (26%), Positives = 131/353 (37%), Gaps = 42/353 (11%)
Query: 182 DEPAVATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPA-PEPQPGSQ 240
D+ V P PP P P A P +P P+ KEEP+E PA P P P
Sbjct: 785 DDSVVIVPEGLPPLPPPPPSGATPPPIAPTGPPTASP-PVPAKEEPEELPAAPGPLPPPP 843
Query: 241 AQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTISILPGGQV 300
PP P L PQ V G G P P + + T+ +
Sbjct: 844 PPP---PPVPGPVTLPP----------PQLVPEGTPGGGGP--PALEEDLTVININSSDE 888
Query: 301 EPDLVLEEVEPPWEDAHQDVSTSPQGTEVVPAYEEENKAVEKMPRELSRIEEEKEDEEEE 360
E + EE E E+ ++ + + +EEE + E+ E E E E+EEEE
Sbjct: 889 EEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEE 948
Query: 361 EEEEEEEEEEEVTEVLLDSCVVSQVGVGQSEEDGTRPQSTSDQKLWEEVGEEAKKEAEEK 420
E+EEEEEE EEV ++ + G E+G P T L
Sbjct: 949 EDEEEEEELEEVEDLEFGT-------AGGEVEEGAPPPPTLPPAL--------------- 986
Query: 421 AKEEAEEVAEEEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCPLM 480
E+ + E E EP E EEP E E + P PE + +
Sbjct: 987 PPPESPPKVQPEPEPEPGLLLEV-EEPGTEEERGADTAPTLA--PEALPSQGEVEREGES 1043
Query: 481 AEENPPSTVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELKALSPAES 533
PP L P+ TL+ + G+ + + P E EE++ + AE+
Sbjct: 1044 PAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAEEEMETETEAEA 1096
Score = 39.3 bits (90), Expect = 0.024
Identities = 62/237 (26%), Positives = 89/237 (37%), Gaps = 54/237 (22%)
Query: 22 QEEEEVEPEPEMEAEVEPEPNPEE---------AETESESMPPEESFKEEEVAV----AD 68
+EEEE E E E E E E E + EE E E E EE F+EEE + +
Sbjct: 889 EEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEE 948
Query: 69 PSPQETKEAALTSTISLRAQGAEISEMNSPSRRVLTWL--MKGVEKVIPQPVHSITEDPA 126
+E +E + G E+ E P + L + KV P+P +P
Sbjct: 949 EDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEP----EPEPG 1004
Query: 127 QILGHGSTGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQP-PKSSEVWRDEPA 185
+L G T+E A DT P L P+ P EV R+ +
Sbjct: 1005 LLLEVEEPG----TEEERGA----DTAPTL-------------APEALPSQGEVEREGES 1043
Query: 186 VATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQAQ 242
A G PP PQE+ E PS P + + E+ + P P+ ++ +
Sbjct: 1044 PAAG------PP--PQEL-----VEEEPSAPPTLLEEETEDGSDKVQPPPETPAEEE 1087
Score = 36.6 bits (83), Expect = 0.15
Identities = 47/194 (24%), Positives = 74/194 (38%), Gaps = 25/194 (12%)
Query: 183 EPAVATGAASDP-APPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQA 241
E V A + P PP +P MGP + PTP P+ P E P AP P
Sbjct: 622 EALVTCAALTHPRVPPLQP--MGP--------TCPTPAPVPPPEAPSPFRAPPFHPPGPM 671
Query: 242 QTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTISILPGGQVE 301
+ P+ P + A P P G + P P + +S+ PG
Sbjct: 672 PSVGSMPSAGP----------MPSAGPMPSA-GPVPSARPGPPTTANHLGLSV-PGLVSV 719
Query: 302 PDLVLEEVEPPWEDAHQDVSTSPQGTEVVPAYEEENKAVEKMPRELSRIEEEKEDEEEEE 361
P +L E +++D +P GT P + ++PR + + +KE+ + E
Sbjct: 720 PPRLLPGPENHRAGSNEDPILAPSGTP-PPTIPPDETFGGRVPRP-AFVHYDKEEASDVE 777
Query: 362 EEEEEEEEEEVTEV 375
E + ++ V V
Sbjct: 778 ISLESDSDDSVVIV 791
Score = 35.0 bits (79), Expect = 0.45
Identities = 26/71 (36%), Positives = 33/71 (46%), Gaps = 5/71 (7%)
Query: 1183 PPAPRTPPEPPGSPPSSPPPASLGRPEGEEEGPAEP--EEHSVRICMSPGPEPGEQILSV 1240
PP P PP PG P + PPP + PEG G P EE I ++ E E+
Sbjct: 840 PPPPPPPPPVPG-PVTLPPPQLV--PEGTPGGGGPPALEEDLTVININSSDEEEEEEEEE 896
Query: 1241 KMPEEREEKAE 1251
+ EE EE+ E
Sbjct: 897 EEEEEEEEEEE 907
Score = 33.9 bits (76), Expect = 1.00
Identities = 32/87 (36%), Positives = 40/87 (45%), Gaps = 14/87 (16%)
Query: 3 GWVQRVLPQPPGTPRKTKMQE-----EEEVEPEPEMEAEVEPEPNPEE---AET----ES 50
G V+ P PP P E + E EPEP + EVE EP EE A+T
Sbjct: 970 GEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVE-EPGTEEERGADTAPTLAP 1028
Query: 51 ESMPPE-ESFKEEEVAVADPSPQETKE 76
E++P + E +E E A P PQE E
Sbjct: 1029 EALPSQGEVEREGESPAAGPPPQELVE 1055
Score = 33.5 bits (75), Expect = 1.3
Identities = 41/174 (23%), Positives = 69/174 (39%), Gaps = 19/174 (10%)
Query: 466 EVQVEDTDADSCPLMAEENPPSTVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEEL 525
E+ +E DS ++ E PP LPPP P+ + + + T +P++ +E EEL
Sbjct: 777 EISLESDSDDSVVIVPEGLPP---LPPPPPSGATPPPIAPTGPPTASPPVPAK-EEPEEL 832
Query: 526 KAL-----------SPAESPVVAWSDPTTPKDTDGQDRAASTASTNSAI-INDRLQELVK 573
A P PV P+ T G + + I IN +E +
Sbjct: 833 PAAPGPLPPPPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEE 892
Query: 574 LFKERTEKVKEKLIDPDVTSDEESPK---PSPAKKAPEPAPDTKPAEAEPVEEE 624
+E E+ +E+ + D +EE + ++ E + + E E EEE
Sbjct: 893 EEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEE 946
Score = 33.5 bits (75), Expect = 1.3
Identities = 25/96 (26%), Positives = 33/96 (34%), Gaps = 6/96 (6%)
Query: 1143 EAAAKQQELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSPPP 1202
E ++ EL E+ + + + EE D + AP P PP PP PP
Sbjct: 934 EFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPP 993
Query: 1203 ASLGRPEGEE------EGPAEPEEHSVRICMSPGPE 1232
PE E E P EE + PE
Sbjct: 994 KVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPE 1029
Score = 32.3 bits (72), Expect = 2.9
Identities = 23/53 (43%), Positives = 26/53 (49%), Gaps = 10/53 (18%)
Query: 1183 PPAPRTPPEPPGSPPSSPPPASLGRPEGEEEGPA--EPEEHSVRICMSPGPEP 1233
PP P PP P G+ P PP A G P PA EPEE + +PGP P
Sbjct: 796 PPLP--PPPPSGATP--PPIAPTGPPTASPPVPAKEEPEE----LPAAPGPLP 840
Score = 32.0 bits (71), Expect = 3.8
Identities = 40/134 (29%), Positives = 55/134 (41%), Gaps = 31/134 (23%)
Query: 264 EMALPQPVLHGKIGEQEPDSPGICDVQTISILPGGQVEPDLVLEEVEPPWEDAHQDVSTS 323
E A P P L + P+SP + P + EP L+LE VE P + + T+
Sbjct: 974 EGAPPPPTLPPAL--PPPESPP-------KVQPEPEPEPGLLLE-VEEPGTEEERGADTA 1023
Query: 324 PQ-GTEVVPAYEE-----ENKAVEKMPREL---------SRIEEEKEDEEE------EEE 362
P E +P+ E E+ A P+EL + +EEE ED + E
Sbjct: 1024 PTLAPEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETP 1083
Query: 363 EEEEEEEEEVTEVL 376
EEE E E E L
Sbjct: 1084 AEEEMETETEAEAL 1097
>gi|27886651 potassium voltage-gated channel, subfamily H, member 6
isoform 2 [Homo sapiens]
Length = 905
Score = 85.1 bits (209), Expect = 4e-16
Identities = 76/382 (19%), Positives = 171/382 (44%), Gaps = 42/382 (10%)
Query: 693 LMDYLCDLIYFLDITVFQTRLQFVRGGD-IITDKKDMRNNYLKSRRFKMDLLSLLPLDFL 751
++D + D+++ +DI V R +V D +++ + + +Y K F +D+++ +P D L
Sbjct: 302 VVDLIVDIMFVVDI-VINFRTTYVNTNDEVVSHPRRIAVHYFKGW-FLIDMVAAIPFDLL 359
Query: 752 YLKVGVNPLLRLPRCLKYMAFFEFNSRLESILSKAYVYRVIRTTAYL-LYSLHLNSCLYY 810
+ G + + L +L A + R++R L YS + + L+
Sbjct: 360 IFRTGSDE----------------TTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFL 403
Query: 811 WASAYQGLGSTHWVYDGVGNSYIRCYYFAVKTLITIG-GLPDPKTLFEIVFQLLNYFTGV 869
+ + HW+ + +L ++G G P T E VF + G
Sbjct: 404 LMCTFALIA--HWLA-------------CICSLTSVGFGNVSPNTNSEKVFSICVMLIGS 448
Query: 870 FAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQG 929
++ + G + ++ +G Y + M +++ F++IP ++ R++ ++++ W
Sbjct: 449 LMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTN 508
Query: 930 MLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYV 989
+D + ++ P+ ++ D+ + ++ ++ F G + + + + ++ P D +
Sbjct: 509 GIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTL 568
Query: 990 CKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGE-ISLLAVGGGNRRTANVVA 1048
G++ +Y I G +++L V+ L +FGE +SL A G + +A+V A
Sbjct: 569 VHLGDVLSTLYFISRGSIEIL---RDDVVVAILGKNDIFGEPVSLHAQPG--KSSADVRA 623
Query: 1049 HGFTNLFILDKKDLNEILVHYP 1070
+ +L + + DL E+L YP
Sbjct: 624 LTYCDLHKIQRADLLEVLDMYP 645
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 80.5 bits (197), Expect = 9e-15
Identities = 91/360 (25%), Positives = 154/360 (42%), Gaps = 38/360 (10%)
Query: 295 LPGGQVEPDLVLEEVEPPWEDAHQDVSTSPQGTEVVPAYEEENKAVEKMPRELSRIEEEK 354
LP G + V ++ E+ + V S + T +V EE + E++ E + +E+
Sbjct: 422 LPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEE 481
Query: 355 EDEEEEEEEEEEEE--EEEVTEVLLDSCVVSQVGVGQSEEDGTRPQSTSDQKLWEEVGEE 412
E +EEE EEEE E EEE + + + + + ++ S + EE
Sbjct: 482 EGKEEEGGEEEEAEGGEEETKSPPAEEAASPE----KEAKSPVKEEAKSPAEAKSPEKEE 537
Query: 413 AKKEAEEKAKEEAEEVAEEEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDT 472
AK AE K+ E+A+ A+EEA+ P+ + KEE ++ AE S P + P + +
Sbjct: 538 AKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKS---PEKAKSPAKEEAKS 594
Query: 473 DADSCPLMAEENPPSTVLPPPSPAKS---DTLIVPSSASGTHRKKLPSEDD--------- 520
A++ ++P P+ AKS + P+ + K P++++
Sbjct: 595 PAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKS 654
Query: 521 -EAEELKALSPAESPVVAWSDPTTPKDTDGQDRAASTASTNSAIINDR---------LQE 570
E EE K+ A+SPV A + + + A S S + + ++E
Sbjct: 655 PEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKE 714
Query: 571 LVKLFKERTEKVKEKLIDPDVTSD---EESPKPSPAKKAPEPAP--DTKPAEAE-PVEEE 624
K ++ VKE+ P+ EE+ P A K+PE A D K EA+ P +EE
Sbjct: 715 EAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKA-KSPEKAKTLDVKSPEAKTPAKEE 773
Score = 73.2 bits (178), Expect = 1e-12
Identities = 112/506 (22%), Positives = 188/506 (37%), Gaps = 54/506 (10%)
Query: 175 KSSEVWRDEPAVATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPK-EEPKEAPAP 233
+ E +E G + A G + P + +P P++ + + P EA +P
Sbjct: 474 EEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSP 533
Query: 234 EPQPG-SQAQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTI 292
E + S A+ S + PA+ E A P E SP + ++
Sbjct: 534 EKEEAKSPAEVKSPEKAKSPAK---------EEAKSPP---------EAKSPEKEEAKSP 575
Query: 293 SILPGGQVEPDLVLEEVEPPWEDAHQDVSTSPQGTEVVPAYEEENKAVE--KMPRELSRI 350
+ + + EE + P E + + SP E E ++ E K P E+
Sbjct: 576 AEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSP 635
Query: 351 EEEKEDEEEEEEEEEE----EEEEEVTEVLLDSCVVSQVGVGQSEEDGTRPQSTSDQKLW 406
E+ K +EE + E+ E+EE + S V ++ + + + ++ S +K
Sbjct: 636 EKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAK 695
Query: 407 EEVGEEAKKE--------AEEKAKEEAEEVAEEEAEKEPQDWAETKEEPEAEAEAASSGV 458
V EEAK E K+ E+A+ +EEA+ + + KEE ++ +A S
Sbjct: 696 SPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEK 755
Query: 459 PAT-------KQHPEVQVEDTDADSCPLMAEENPPSTVLPP---PSPAKSDTLIVPSSAS 508
T + P + + AD P A+ V P SP K D
Sbjct: 756 AKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIP 815
Query: 509 GTHRKKLP-SEDDEAEELKALSPAESPVVAWSDPTTPKDTDGQDRAASTASTNSAIINDR 567
K P E+++ +E+K P + P TPK + +D A A
Sbjct: 816 KKEEVKSPVKEEEKPQEVKVKEPPKK-AEEEKAPATPKTEEKKDSKKEEAPKKEA----P 870
Query: 568 LQELVKLFKERTEKVKEKLIDPDVTSDEESPK-PSPAKKAP---EPAPDTKPAEAEPVEE 623
++ + + EK KE ++ E+ K P+P K+AP E D KP E V +
Sbjct: 871 KPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAK 930
Query: 624 EHYCDMLCCKFKHRPWKKYQFPQSID 649
+ D + KK P+ D
Sbjct: 931 KEPDDAKAKEPSKPAEKKEAAPEKKD 956
Score = 70.1 bits (170), Expect = 1e-11
Identities = 139/631 (22%), Positives = 235/631 (37%), Gaps = 103/631 (16%)
Query: 9 LPQPPGTPRKTKMQEEEEVE--PEPEMEAEVEPEPNPEEAETESESMPPEESFKEEEVAV 66
LP+ P K++ EE+++ + E E + E E TE + E+ KEEE
Sbjct: 426 LPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKE 485
Query: 67 ADPSPQETKEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHSITEDPA 126
+ +E E T S A+ E SP EK PV + PA
Sbjct: 486 EEGGEEEEAEGGEEETKSPPAE-----EAASP------------EKEAKSPVKEEAKSPA 528
Query: 127 QILGHGSTGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVWRDEPAV 186
+ + E EA + + + + + PP++ ++E
Sbjct: 529 EAK----------SPEKEEAKSPAEVKSPEKA----KSPAKEEAKSPPEAKSPEKEE--- 571
Query: 187 ATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAP-EPQPGSQAQTSS 245
A PA P++ K A+E P + P++A +P + + S A+ S
Sbjct: 572 ----AKSPAEVKSPEKA--KSPAKEEAKSPAEA-----KSPEKAKSPVKEEAKSPAEAKS 620
Query: 246 LPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTISILPGGQVEPDLV 305
P ++ A+ A V + P ++E SP + V
Sbjct: 621 --PVKEEAKSPAEVKSPEKAKSPT--------KEEAKSPEKAKSPEKEEAKSPEKAKSPV 670
Query: 306 LEEVEPPWEDAHQDVSTSPQGTEVVPA-YEEENKAVEKMPRELSRIEEEKEDEEEEEEEE 364
E + P E A V + E + +EE K+ EK + EE K E+ + +
Sbjct: 671 KAEAKSP-EKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVK--EEAKSPEKAKSPVK 727
Query: 365 EEEEEEEVTEVLLDSCVVSQVGVGQSEEDGTRPQSTSDQKLWEEVGEEAKKEAEEKAKEE 424
EE + E ++ V + + + +S K + EAK A+E+A+
Sbjct: 728 EEAKTPEK----------AKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSP 777
Query: 425 AEEVAEEEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCPLMAEEN 484
A++ E+ K P KEE ++ E A S + + PE ++ + P+ EE
Sbjct: 778 ADKFPEKA--KSP-----VKEEVKSP-EKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEK 829
Query: 485 PPSTVLPPPSPAKSDTLIVPSSASGTHRKKLPSED-----------DEAEELKALSPAES 533
P + P P K++ P++ +K E+ +E +E P ES
Sbjct: 830 PQEVKVKEP-PKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKES 888
Query: 534 PVVAWSDPTTPKDTDGQDRAASTASTNSAIINDRLQELVKLFKERTEKVKEKLIDPDVTS 593
V A K + +D+ A ++E K KE+TE K+ +PD
Sbjct: 889 KVEA-------KKEEAEDKKKVPTPEKEAPAKVEVKEDAKP-KEKTEVAKK---EPDDAK 937
Query: 594 DEESPKPSPAKKAPEPAPDTKPAEAEPVEEE 624
+E KP+ K+A DTK +A+ EE+
Sbjct: 938 AKEPSKPAEKKEAAPEKKDTKEEKAKKPEEK 968
Score = 68.6 bits (166), Expect = 4e-11
Identities = 137/618 (22%), Positives = 220/618 (35%), Gaps = 96/618 (15%)
Query: 22 QEEEEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFKEEEVAVADPSPQETKEAALTS 81
+EE+E + E E E E E E E++S P EE+ E+ A P +E K A
Sbjct: 473 EEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEA-KSPVKEEAKSPA--- 528
Query: 82 TISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHSITEDPAQILGHGSTGDTGCTD 141
A+ E E SP+ +K EK P + P + +
Sbjct: 529 ----EAKSPEKEEAKSPAE------VKSPEKA-KSPAKEEAKSPPE----------AKSP 567
Query: 142 EPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVWRDEPAVATGAASDPAPPGRPQ 201
E EA + + P K+ ++E A PA P+
Sbjct: 568 EKEEAKSPAEVK------------------SPEKAKSPAKEE-------AKSPAEAKSPE 602
Query: 202 EMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQAQTSSLPPTRDPARLVAWVLH 261
+ K +E P KEE K +PA P +A++ + + P + A
Sbjct: 603 K--AKSPVKEEAKSPAEAKSPVKEEAK-SPAEVKSP-EKAKSPTKEEAKSPEK--AKSPE 656
Query: 262 RLEMALPQPVLHGKIGEQEPDSPGICDVQTISILPGGQVEPDLVLEEVEPPWEDAHQDVS 321
+ E P+ E + V+ + P P V EE + P E A V
Sbjct: 657 KEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSP--VKEEAKSP-EKAKSPVK 713
Query: 322 TSPQGTEVVPAYEEENKAVEKMPRELSRIEEEKEDEEEEEEEEEEEEEEEVTEVLLDSCV 381
+ E KA + E E+ K +EE + E+ + E + L V
Sbjct: 714 EEAKSPE---------KAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTL---DV 761
Query: 382 VSQVGVGQSEEDGTRPQSTSDQKLWEEVGEEAK--KEAEEKAKEEA----------EEVA 429
S ++E+ P +K V EE K ++A+ KE+A EEV
Sbjct: 762 KSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVK 821
Query: 430 EEEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCPLMAEENPPSTV 489
E+E + KE P+ E + P T++ + + E+ P E
Sbjct: 822 SPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPA 881
Query: 490 LPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEA----EELKALSPAESPVVAWSDPTTPK 545
+ P +K + +KK+P+ + EA E + P E VA +P K
Sbjct: 882 VEKPKESK----VEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAK 937
Query: 546 DTDGQDRAASTASTNSAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKPSPAKK 605
+ A + D +E K +E+ K + K + D T +E KP A+K
Sbjct: 938 AKEPSKPAEKKEAAPEK--KDTKEEKAKKPEEK-PKTEAKAKEDDKTLSKEPSKPK-AEK 993
Query: 606 APEPAPDTKPAEAEPVEE 623
A E + T +++P E+
Sbjct: 994 A-EKSSSTDQKDSKPPEK 1010
Score = 68.6 bits (166), Expect = 4e-11
Identities = 103/503 (20%), Positives = 194/503 (38%), Gaps = 61/503 (12%)
Query: 10 PQPPGTPRKTKMQEEEEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFKEEEVAVADP 69
P +P K K +EE + PE ++ P EEA++ +E PE++ + P
Sbjct: 541 PAEVKSPEKAKSPAKEEAKSPPEAKS-----PEKEEAKSPAEVKSPEKAKSPAKEEAKSP 595
Query: 70 SPQETKEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHSITEDPAQIL 129
+ ++ E A + ++ + +E SP + E P+ S T++ A+
Sbjct: 596 AEAKSPEKAKSP---VKEEAKSPAEAKSPVKEEAK---SPAEVKSPEKAKSPTKEEAK-- 647
Query: 130 GHGSTGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVWRD---EPAV 186
+ + + E EA + + ++ + + + KS E + E A
Sbjct: 648 ----SPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAK 703
Query: 187 ATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEE---PKEAPAPEPQPGSQAQT 243
+ A P K +E P KEE P++A +PE ++
Sbjct: 704 SPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKS 763
Query: 244 -SSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTISILPGGQVEP 302
+ P ++ AR A + PV ++ SP ++
Sbjct: 764 PEAKTPAKEEARSPA---DKFPEKAKSPVKEEVKSPEKAKSP---------------LKE 805
Query: 303 DLVLEEVEPPWEDAHQDVSTSPQGTEVVPAYEEENKAVEKMPRELSRIEEEKEDEEEEEE 362
D E E P ++ + + + V E KA E+ + EE+K+ ++EE
Sbjct: 806 DAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAP 865
Query: 363 EEE------EEEEEEVTEVLLDSCVVSQVGVGQSEEDGTRPQSTSDQKLW-------EEV 409
++E EE++E E +S V ++ + ++ P+ + K+ +E
Sbjct: 866 KKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEK 925
Query: 410 GEEAKKEAEE-KAKEEAEEVAEEEAEKEPQDWAETK-----EEPEAEAEAASSGVPATKQ 463
E AKKE ++ KAKE ++ ++EA E +D E K E+P+ EA+A +K+
Sbjct: 926 TEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKE 985
Query: 464 HPEVQVEDTDADSCPLMAEENPP 486
+ + E + S + PP
Sbjct: 986 PSKPKAEKAEKSSSTDQKDSKPP 1008
Score = 58.9 bits (141), Expect = 3e-08
Identities = 124/611 (20%), Positives = 216/611 (35%), Gaps = 78/611 (12%)
Query: 18 KTKMQEEEEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFKEEEVAVADPSPQETKEA 77
K + +EEE E E E E +P E S + KEE + A+ E +EA
Sbjct: 479 KEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEA 538
Query: 78 ALTSTIS--------LRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHSITEDPAQIL 129
+ + + + E SP + E P+ S ++ A+
Sbjct: 539 KSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEE---AKSPAEVKSPEKAKSPAKEEAKSP 595
Query: 130 GHGSTGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVWRDEPAVATG 189
+ + + EA + + ++ E + P K+ ++E
Sbjct: 596 AEAKSPEKAKSPVKEEAKSPAEAKSPVK----EEAKSPAEVKSPEKAKSPTKEE------ 645
Query: 190 AASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQAQTSSLPPT 249
A P P+ K +A+ +P+ + K P++A +P +A+ S
Sbjct: 646 -AKSPEKAKSPE----KEEAKSPEKAKSPVKAEAK-SPEKAKSP-----VKAEAKSPEKA 694
Query: 250 RDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTISILPGGQVEPDLVLEEV 309
+ P + A + PV ++ SP + +T E E+
Sbjct: 695 KSPVKEEA----KSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKA 750
Query: 310 EPPWEDAHQDVSTSPQGTEVVPAYEEENKAVEKMPREL-SRIEEEKEDEEEEEEEEEEEE 368
+ P + DV SP+ PA EE +K P + S ++EE + E+ + +E+
Sbjct: 751 KSPEKAKTLDVK-SPEAK--TPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDA 807
Query: 369 EEEVTEVLLDSCVVSQVGVGQSEEDGTRPQSTSDQKLWEEVGEEAKKEAEEKAKEEAEEV 428
+ E+ V S V + EE + K EE A + EEK + EE
Sbjct: 808 KAPEKEIPKKEEVKSPV---KEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEA 864
Query: 429 AEEEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCPLMAEENPPST 488
++EA P+ E K+EP E + S V A K+ E D P +E P
Sbjct: 865 PKKEA---PKPKVEEKKEPAVE-KPKESKVEAKKEEAE------DKKKVPTPEKEAPAKV 914
Query: 489 VLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESPVVAWSDPTTPKDTD 548
+ + K T + E D+A+ + PAE A P+ D
Sbjct: 915 EVKEDAKPKEKTEVA------------KKEPDDAKAKEPSKPAEKKEAA------PEKKD 956
Query: 549 GQDRAASTASTNSAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKPSPAKKAPE 608
++ A + +E K + K K + + ++D++ KP PE
Sbjct: 957 TKEEKAKKPEEKPK-TEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKP------PE 1009
Query: 609 PAPDTKPAEAE 619
A + K A+ +
Sbjct: 1010 KATEDKAAKGK 1020
Score = 58.5 bits (140), Expect = 4e-08
Identities = 117/566 (20%), Positives = 207/566 (36%), Gaps = 67/566 (11%)
Query: 14 GTPRKTKMQEEEEVEPEPEMEAEVEPE---PNPEEAETESESMPPEESFKEEEVAVAD-P 69
G + + EEE P E A E E P EEA++ +E+ PE KEE + A+
Sbjct: 489 GEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPE---KEEAKSPAEVK 545
Query: 70 SPQETKEAALTSTISL-RAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHSITEDPAQI 128
SP++ K A S A+ E E SP+ E P+ S ++ A+
Sbjct: 546 SPEKAKSPAKEEAKSPPEAKSPEKEEAKSPA-----------EVKSPEKAKSPAKEEAKS 594
Query: 129 LGHGSTGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVWRDE---PA 185
+ + + EA + + ++ E + P K+ ++E P
Sbjct: 595 PAEAKSPEKAKSPVKEEAKSPAEAKSPVKE----EAKSPAEVKSPEKAKSPTKEEAKSPE 650
Query: 186 VATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQAQTSS 245
A + A + K +A+ +P+ + K P++A +P + + +
Sbjct: 651 KAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKS-PEKAKSPVKEEAKSPEKAK 709
Query: 246 LP---PTRDPARLVAWVLHRLEMALPQ----PVLHGKIGEQEPDSPGICDVQTISILPGG 298
P + P + + V + E P+ PV ++ SP +T+ +
Sbjct: 710 SPVKEEAKSPEKAKSPV--KEEAKTPEKAKSPVKEEAKSPEKAKSPE--KAKTLDVKSP- 764
Query: 299 QVEPDLVLEEVEPPWEDAHQDVSTSPQGTEVVPAYEEENKAVEKMPRELSRIEEEKEDEE 358
E P E+A P+ + E ++ K P + EKE +
Sbjct: 765 --------EAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPK 816
Query: 359 EEEEEEEEEEEEEVTEVLLDSCVVSQVGVGQSEEDGTRPQSTS--DQKLWEEVGEEAKK- 415
+EE + +EEE+ EV V + E+ P++ D K E +EA K
Sbjct: 817 KEEVKSPVKEEEKPQEVK----VKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKP 872
Query: 416 EAEEKAKEEAEEVAEEEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDAD 475
+ EEK + E+ E + E + ++ + K+ P E EA + P+ + E
Sbjct: 873 KVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTE----- 927
Query: 476 SCPLMAEENPPSTVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESPV 535
+A++ P PS P K E+ E KA E
Sbjct: 928 ----VAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKA---KEDDK 980
Query: 536 VAWSDPTTPKDTDGQDRAASTASTNS 561
+P+ PK + ++++ST +S
Sbjct: 981 TLSKEPSKPK-AEKAEKSSSTDQKDS 1005
Score = 44.3 bits (103), Expect = 7e-04
Identities = 33/118 (27%), Positives = 50/118 (42%), Gaps = 6/118 (5%)
Query: 1133 RARLKELAALEAAAKQQELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPEP 1192
++ +KE A A AK E E+AKS +VK E + +P KE A PP ++P +
Sbjct: 517 KSPVKEEAKSPAEAKSPEK-EEAKSPAEVKSPEKAKSP-----AKEEAKSPPEAKSPEKE 570
Query: 1193 PGSPPSSPPPASLGRPEGEEEGPAEPEEHSVRICMSPGPEPGEQILSVKMPEEREEKA 1250
P+ + +EE + E S SP E + K P + E K+
Sbjct: 571 EAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKS 628
Score = 39.7 bits (91), Expect = 0.018
Identities = 30/126 (23%), Positives = 54/126 (42%), Gaps = 10/126 (7%)
Query: 1131 HLRARLKE-LAALEAAAKQ----QELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPA 1185
H++ + +E + +E + K+ +E E+ + +++V EE A ++ +E + A
Sbjct: 435 HIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEA 494
Query: 1186 PRTPPEPPGSPPSSPPPASLGRPEGEEEGPAEPEEHSVRICMSPGPEPGEQILSVKMPEE 1245
E SPP PE E + P + E S SP E + VK PE+
Sbjct: 495 EGGEEET-----KSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEK 549
Query: 1246 REEKAE 1251
+ A+
Sbjct: 550 AKSPAK 555
Score = 36.2 bits (82), Expect = 0.20
Identities = 34/116 (29%), Positives = 47/116 (40%), Gaps = 10/116 (8%)
Query: 1137 KELAALEAAAKQQELVEQAKSSQDVKGEEGSAAP--DQHTHPKEAATDPPAPRTPPEPPG 1194
KE A AK E E+AKS +VK E + +P ++ P EA + A E
Sbjct: 555 KEEAKSPPEAKSPEK-EEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAK 613
Query: 1195 SPPSSPPPASLGRPEGEEEGPAEPEEHSVRICMSPGPEPGEQILSVKMPEEREEKA 1250
SP + P +EE + E S SP E + K PE+ E K+
Sbjct: 614 SPAEAKSPV-------KEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKS 662
Score = 33.1 bits (74), Expect = 1.7
Identities = 36/125 (28%), Positives = 50/125 (40%), Gaps = 18/125 (14%)
Query: 1124 AKGGKLAHLRARLKELAALEAAAKQQELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDP 1183
A+GG+ +E A+ E AK + E+AKS + K E KE A P
Sbjct: 494 AEGGEEETKSPPAEEAASPEKEAKSP-VKEEAKSPAEAKSPE-----------KEEAKSP 541
Query: 1184 PAPRTPPE---PPGSPPSSPPPASLGRPEGEEEGPAEPEEHSVRICMSPGPEPGEQILSV 1240
++P + P SPP A PE +EE + E S SP E +
Sbjct: 542 AEVKSPEKAKSPAKEEAKSPPEAK--SPE-KEEAKSPAEVKSPEKAKSPAKEEAKSPAEA 598
Query: 1241 KMPEE 1245
K PE+
Sbjct: 599 KSPEK 603
Score = 32.7 bits (73), Expect = 2.2
Identities = 26/117 (22%), Positives = 44/117 (37%), Gaps = 8/117 (6%)
Query: 1137 KELAALEAAAKQQELVEQAKSSQDVKGEEGSAAPDQHTHP--KEAATDPPAPRTPPEPPG 1194
KE E ++E E + E +A+P++ KE A P ++P +
Sbjct: 479 KEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEA 538
Query: 1195 SPPSSPPPASLGRPEGEEEGPAEPEEHSVRICMSPGPEPGEQILSVKMPEEREEKAE 1251
P+ + +EE + PE SP E + VK PE+ + A+
Sbjct: 539 KSPAEVKSPEKAKSPAKEEAKSPPE------AKSPEKEEAKSPAEVKSPEKAKSPAK 589
Score = 31.2 bits (69), Expect = 6.5
Identities = 32/119 (26%), Positives = 47/119 (39%), Gaps = 16/119 (13%)
Query: 1137 KELAALEAAAKQQELV-----EQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPE 1191
KE A A K E E+AKS + K E + +P KE A P ++P +
Sbjct: 569 KEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSP-----VKEEAKSPAEAKSPVK 623
Query: 1192 PPGSPPSSPPPASLGRPEGEEEGPAEPEEHSVRICMSPGPEPGEQILSVKMPEEREEKA 1250
+ PA + PE + + P + E S SP E + K P + E K+
Sbjct: 624 -----EEAKSPAEVKSPE-KAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKS 676
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 80.5 bits (197), Expect = 9e-15
Identities = 116/505 (22%), Positives = 180/505 (35%), Gaps = 49/505 (9%)
Query: 24 EEEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFKEEEV-AVADPSPQETKEAALTST 82
E E E +PE E PE + E E E+ P E + E A P ++ +
Sbjct: 1839 EAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWE 1898
Query: 83 ISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHSITEDPAQILGHGSTGDTGCTDE 142
+ ++GAE E ++ + + +P E AQ + G T
Sbjct: 1899 VQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAE--AQEAEEAAQEAEGQTQP 1956
Query: 143 PNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVWRDEPAVATGAASDPAPPGRPQE 202
+E +E+Q+ + P+S +V E V T A A P
Sbjct: 1957 ESEVIESQEAEEEAQ----------------PESEDVEALEVEVETQEAEGEAQPESEDV 2000
Query: 203 MGPK----LQARETPSLPTP--IPLQPKEEPKEAPAPEPQPGSQAQTSSLPPTRDPARLV 256
P+ +Q E + P + QPK E +EA E + +Q P D
Sbjct: 2001 EAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGE--TQKTEGDAQPESDGVEAP 2058
Query: 257 AWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTISILPGGQVEPDLVLEEVEPPWEDA 316
E + + GE P+S + D Q G+ +P+ E VE P +
Sbjct: 2059 E---AEEEAQEAEGEVQEAEGEAHPESEDV-DAQEAE----GEAQPES--EGVEAPEAEG 2108
Query: 317 HQDVSTSPQGTEVVPAYEEENKAVEKMPRELSRIEEEKEDEEEEEEEEEEEEEEEVTEVL 376
+ + E + E++ +E P + E E E ++ E E + E E E
Sbjct: 2109 EAQKAEGIEAPETEGEAQPESEGIEA-PEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQ 2167
Query: 377 LDSCVVSQVGVGQSEEDGTRPQSTSDQKLWEEVGEEAKKEAEEKAKEEAEEV----AEEE 432
Q E +G + E G EA EAE +A+ E E V AEEE
Sbjct: 2168 ------EAEEEAQPELEGVEAPEAEGEAQPESEGIEAP-EAEGEAQPELEGVEAPEAEEE 2220
Query: 433 AEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCPLMAEENPPSTVLPP 492
A+ EP+ + E EA+ E+ K P+V + D ++ + P PP
Sbjct: 2221 AQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPP 2280
Query: 493 PSPAKSDTLIVPSSASGTHRKKLPS 517
PSP P S +G + S
Sbjct: 2281 PSPGGDTPHQRPGSQTGPSSSRASS 2305
Score = 73.2 bits (178), Expect = 1e-12
Identities = 107/475 (22%), Positives = 176/475 (37%), Gaps = 63/475 (13%)
Query: 172 QPPKSSEVWRDEPAVATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAP 231
+ P++ ++ A + D P E P+ + ETP + QP+ E EAP
Sbjct: 1852 EAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEV--QPESEGAEAP 1909
Query: 232 APEPQPGSQAQTSSLPPTR---DPARLVAWVLHRLEMALP-----QP---VLHGKIGEQE 280
E + + ++ T +P A E A QP V+ + E+E
Sbjct: 1910 EAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEE 1969
Query: 281 --PDSPGI--CDVQTISILPGGQVEP---DLVLEEVEPPWEDAHQDVSTSPQGTEVVPAY 333
P+S + +V+ + G+ +P D+ E E ++A ++ G E P
Sbjct: 1970 AQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKS 2029
Query: 334 E-EENKAVEKMPRELSRIEEEKED--EEEEEEEEEEEEEEEVTEVLLDSCVVSQ------ 384
E EE + VE ++ + + D E E EEE +E E EV E ++ S+
Sbjct: 2030 EGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQE 2089
Query: 385 -VGVGQSEEDGTRPQSTSDQKLWEEVGEEAKKEAEEKAKEEAEEVAEEEAEKEPQDWAET 443
G Q E +G + E E + E E + + E E E E E +P+
Sbjct: 2090 AEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVE 2149
Query: 444 KEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCPLMAEENPPSTVLPPPSPAKSDTLIV 503
++ E EA+ S G+ A + E Q E ++ E P S + P
Sbjct: 2150 AQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAP---------- 2199
Query: 504 PSSASGTHRKKLPS-EDDEAEELKALSP--AESP-VVAWSDPTTPKDTDGQDRAASTAST 559
A G + +L E EAEE P E+P + P + +T G+ + + S
Sbjct: 2200 --EAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSL 2257
Query: 560 NSAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKPSPAKKAPEPAPDTK 614
++E+ E V D +P PSP P P ++
Sbjct: 2258 GDG---------------QSEEASES--SSPVPEDRPTPPPSPGGDTPHQRPGSQ 2295
Score = 47.0 bits (110), Expect = 1e-04
Identities = 126/602 (20%), Positives = 207/602 (34%), Gaps = 112/602 (18%)
Query: 13 PGTPRKTKMQEEEEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFKEEEVAVADPSPQ 72
P + ++ + +PEPE + P+ E + PE + A AD
Sbjct: 1006 PAQAGQQSLEGDPGQDPEPEGALLGSSDTGPQSGEGVPQGAAPEGVSEAPAEAGAD---- 1061
Query: 73 ETKEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHSITEDPAQILGHG 132
+EA +SLRA +S S +++ LM G ++ P V ++ A+ L
Sbjct: 1062 --REAPAGCRVSLRALPGRVSA----STQIMRALM-GSKQGRPSSVPEVSRPMARRLSCS 1114
Query: 133 STGDTGCT--------------------DEPN--EALE-AQDTRPG-------LRLLLWL 162
+ C D P E L ++D PG L LW
Sbjct: 1115 AGALITCLASLQLFEEDLGSPASKVRFKDSPRYQELLSISKDLWPGCDVGEDQLDSGLW- 1173
Query: 163 EQNLERVLPQPPKSSEVWRDEPAVATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQ 222
E + LP + P ++G G + P + T +PL+
Sbjct: 1174 ELTWSQALPDLGSHAMTENFTPTSSSGVDISSGSGGSGESSVPCAMDGTLVTQGTELPLK 1233
Query: 223 PKEEPKEAPAPEPQPGSQAQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPD 282
+ ++ E + Q PT AR A + E E D
Sbjct: 1234 TSNQRPDSRTYESPGDLENQQQCCFPTFLNARACACATNE--------------DEAERD 1279
Query: 283 SPGICDVQTISILPGGQVEPDLVLEEVEPPWEDAHQDVSTSPQGTEVVPAYEEENKAVEK 342
S + L V+ ++ LEE + T +G + EE K E
Sbjct: 1280 SEEQRASSNLEQLAENTVQEEVQLEETKE---------GTEGEGLQEEAVQLEETKTEEG 1330
Query: 343 MPRELSRIEEEKEDEEEEEEEEEEEEEEEVTEVLLDSCVVSQVGVGQSEEDGTRPQSTSD 402
+ E ++EE KE E E ++EEE + EE + + G +E+G +
Sbjct: 1331 LQEEGVQLEETKETEGEGQQEEEAQLEE-----------IEETGGEGLQEEGVQ------ 1373
Query: 403 QKLWEEVGEEAKKEAEEKAKEEA--EEVAEEEAEKEPQDWAETKEEPEAEAEAASSGVPA 460
EEV E + + +A EE EE EE Q+ +E P+ + V
Sbjct: 1374 ---LEEVKEGPEGGLQGEALEEGLKEEGLPEEGSVHGQELSEA-SSPDGKGSQEDDPV-- 1427
Query: 461 TKQHPEVQVEDTDADSCPLMAEENPPSTVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDD 520
Q E A+ CP E P PP +++D PS+ SE
Sbjct: 1428 --QEEEAGRASASAEPCPAEGTEEPTE---PPSHLSETD----PSA----------SERQ 1468
Query: 521 EAEELK-ALSPAESPVVAWSDPTTPKDTDGQDRAASTASTNSAIINDRLQELVKLFKERT 579
+L+ L + + T + T G +S+ + ++A+ D + V + ++T
Sbjct: 1469 SGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPI--WVSVLLKKT 1526
Query: 580 EK 581
EK
Sbjct: 1527 EK 1528
Score = 46.2 bits (108), Expect = 2e-04
Identities = 144/652 (22%), Positives = 225/652 (34%), Gaps = 64/652 (9%)
Query: 10 PQPPGTPRKTKMQEEE------EVEPEPEMEAEVEPEPNPEEAETESESMPPEESFKEEE 63
P G+ +QEEE EP P E EP +ET+ + + + E
Sbjct: 1416 PDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEP 1475
Query: 64 VAVADPSP----QETKEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVH 119
P QE +A T + R+ S ++ L+K EK +
Sbjct: 1476 GLEKPPGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLA 1535
Query: 120 SITEDPAQILGHGSTGDTGCTDEPNEALEAQDTRPGL-----RLLLWLEQNLERVLPQPP 174
S A++ D D+ L+ QD L R L L+ R++ +PP
Sbjct: 1536 SAV---AELRARWGLQDNDLLDQMAAELQ-QDVAQRLQDSTKRELQKLQGRAGRMVLEPP 1591
Query: 175 KSSEVWRDEPAVAT--------GAASDPAPPGRPQEMGP-KLQARETPSLPTPIPLQPKE 225
+ E E + T G + A R +GP + P+L T + Q E
Sbjct: 1592 R--EALTGELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGE 1649
Query: 226 EPKEAPAPEPQPGSQAQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPG 285
E A E P + P A + A E Q +L K GE
Sbjct: 1650 E---AEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQRKRGEHT----- 1701
Query: 286 ICDVQTISILPGGQVEPDLVLEEVEPPWEDAHQDVSTSPQGTEVVPAYEEENKAVEKMPR 345
D + + PG V+ +S P E E+ + +++ R
Sbjct: 1702 --DGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDE-----GEDGEGSQRLNR 1754
Query: 346 ELSRIEEEKEDEEEEEEEEEEEEEEEVTEVLLDSCVVSQVGVGQSEEDGTRPQSTSDQKL 405
+ E E + +E E + E T + Q G G SE T Q + +
Sbjct: 1755 DKDPKLGEAEGDAMAQEREGKTHNSE-TSAGSELGEAEQEGEGISERGETGGQGSGHEDN 1813
Query: 406 WEEVGEEAKKEAEEKAKEE-AEEVAEEEAEKEPQDWAETKEEPEAEAEA---------AS 455
+ GE A ++ + + AE + EAE E Q +E E PEAE +A S
Sbjct: 1814 LQ--GEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPES 1871
Query: 456 SGVPATKQHPEVQVEDTDADSCPLMAEENPPSTVLPPPSPAKSDTLIVPS-SASGTHRKK 514
V A + E Q E D ++ E P S P K S A T +
Sbjct: 1872 EDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGED 1931
Query: 515 LP-SEDDEAEEL-KALSPAESPVVAWSDPTTPKDTDGQDRAASTASTNSAIINDRLQELV 572
P SE EA+E +A AE S+ ++ + ++ + + + QE
Sbjct: 1932 EPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAE-EEAQPESEDVEALEVEVETQEAE 1990
Query: 573 KLFKERTEKVKEKLIDPDVTSDEESPKPSPAKKAPEPAPDTKPAEAEPVEEE 624
+ +E V+ + ++ EE +P E P ++ EA+ VE E
Sbjct: 1991 GEAQPESEDVEAPEAEGEMQEAEEEAQPE--SDGVEAQPKSEGEEAQEVEGE 2040
Score = 38.5 bits (88), Expect = 0.041
Identities = 92/454 (20%), Positives = 154/454 (33%), Gaps = 90/454 (19%)
Query: 22 QEEEEVEPEPE----MEAEVEPEPNPEEAETESESMPPEESFKEEEVAVADPSPQETKEA 77
+ E E +PE E EAE E + EEA+ ES+ + + + EE + Q+T+
Sbjct: 1988 EAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGD 2047
Query: 78 ALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHSITEDPAQILGHGSTGDT 137
A + + A AE + +G + H +ED + + G+
Sbjct: 2048 AQPESDGVEAPEAEEEAQEA----------EGEVQEAEGEAHPESED---VDAQEAEGEA 2094
Query: 138 GCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVWRDEPAVATGAASDPAPP 197
E EA EA+ E + P E + + A A
Sbjct: 2095 QPESEGVEAPEAEG-----------EAQKAEGIEAPETEGEAQPESEGIEAPEAEGEA-- 2141
Query: 198 GRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQAQTSSLPPTRDPARLVA 257
+P+ G + Q E + QP+ E EA E + + + P
Sbjct: 2142 -QPESEGVEAQDAEGEA-------QPESEGIEAQEAEEEAQPELEGVEAPEAE------- 2186
Query: 258 WVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTISILPGGQVEPDLVLEEVEPPWEDAH 317
GE +P+S GI + G+ +P+ LE VE P +A
Sbjct: 2187 -------------------GEAQPESEGIEAPEA-----EGEAQPE--LEGVEAP--EAE 2218
Query: 318 QDVSTSPQGT-------EVVPAYEEENKAVEKMPRELSRIEEEKEDEEEEEEEEEEEEEE 370
++ P+G E P E E + +K ++S + + E+ E E+
Sbjct: 2219 EEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPT 2278
Query: 371 EVTEVLLDS---CVVSQVGVGQSEEDG----TRPQSTSDQKLWEEVGEEAKKEAEEKAKE 423
D+ SQ G S + S +D L + +AK A+
Sbjct: 2279 PPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAER 2338
Query: 424 EAEEVAEEEAEKEPQDWAETKEEPEAEAEAASSG 457
+A + E + E ++ PE + AS G
Sbjct: 2339 KATRMYPESSTSEQEEAPLGSRTPE---QGASEG 2369
Score = 38.5 bits (88), Expect = 0.041
Identities = 64/244 (26%), Positives = 92/244 (37%), Gaps = 26/244 (10%)
Query: 20 KMQE-EEEVEPE-------PEMEAEVEPEPNPEEAETESESMPPEESFK----EEEVAVA 67
+MQE EEE +PE P+ E E E E +TE ++ P + + EEE A
Sbjct: 2008 EMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEA 2067
Query: 68 DPSPQETKEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHSITEDPAQ 127
+ QE + A + + AQ AE E S V +G + TE AQ
Sbjct: 2068 EGEVQEAEGEAHPESEDVDAQEAE-GEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQ 2126
Query: 128 ILGHG--STGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVWRDEPA 185
G + G +E +EAQD + + +E + E+ E
Sbjct: 2127 PESEGIEAPEAEGEAQPESEGVEAQDAEGEAQP---ESEGIEAQEAEEEAQPELEGVEAP 2183
Query: 186 VATGAASDPA----PPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAP--EPQPGS 239
A G A + P E P+L+ E P QP+ E E P E QP S
Sbjct: 2184 EAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEE--EAQPEPEGVETPEAEGEAQPES 2241
Query: 240 QAQT 243
+ +T
Sbjct: 2242 EGET 2245
Score = 32.3 bits (72), Expect = 2.9
Identities = 21/71 (29%), Positives = 29/71 (40%), Gaps = 6/71 (8%)
Query: 1175 HPKEAATDPPAPRTPPEPPGSP-PSSPPPASLGRPEGEEEGPAEPEEHSVRICMSPGPEP 1233
H ++ + A E +P PSSP +GRPE GP H C PG +P
Sbjct: 779 HTSDSCSKSGAASLGEEARDTPQPSSPLVLQVGRPEQGAVGP-----HRSHCCSQPGTQP 833
Query: 1234 GEQILSVKMPE 1244
++ PE
Sbjct: 834 AQEAQRGPSPE 844
Score = 32.0 bits (71), Expect = 3.8
Identities = 27/108 (25%), Positives = 43/108 (39%), Gaps = 2/108 (1%)
Query: 1141 ALEAAAKQQELVEQAKSSQDVKGE-EGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSS 1199
A E A + E VE ++ + + E EG AP+ + AP E P
Sbjct: 2169 AEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGV 2228
Query: 1200 PPPASLGRPEGEEEGPAEPEEH-SVRICMSPGPEPGEQILSVKMPEER 1246
P + G + E EG + E+ S ++ + G S +PE+R
Sbjct: 2229 ETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDR 2276
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.131 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,537,162
Number of Sequences: 37866
Number of extensions: 3783153
Number of successful extensions: 99912
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1049
Number of HSP's successfully gapped in prelim test: 1877
Number of HSP's that attempted gapping in prelim test: 32799
Number of HSP's gapped (non-prelim): 35395
length of query: 1251
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1137
effective length of database: 13,930,794
effective search space: 15839312778
effective search space used: 15839312778
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.