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Search of human proteins with 21536485
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21536485 HIR histone cell cycle regulation defective homolog
A [Homo sapiens]
(1017 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21536485 HIR histone cell cycle regulation defective homolog ... 2033 0.0
gi|4885105 chromatin assembly factor 1 subunit B [Homo sapiens] 148 3e-35
gi|4757988 WD repeat domain 39 [Homo sapiens] 82 2e-15
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 75 4e-13
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 75 4e-13
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 75 4e-13
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 75 4e-13
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 74 5e-13
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 73 1e-12
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 73 1e-12
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 73 1e-12
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 73 1e-12
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 72 3e-12
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 71 6e-12
gi|19913367 transducin beta-like 1Y [Homo sapiens] 69 2e-11
gi|19913365 transducin beta-like 1Y [Homo sapiens] 69 2e-11
gi|15150805 transducin beta-like 1Y [Homo sapiens] 69 2e-11
gi|62234438 Notchless gene homolog isoform b [Homo sapiens] 69 2e-11
gi|118402582 cell division cycle 20 [Homo sapiens] 69 3e-11
gi|23199987 WD repeat domain 5B [Homo sapiens] 68 5e-11
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 66 2e-10
gi|157739942 gemin 5 [Homo sapiens] 65 2e-10
gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens] 65 4e-10
gi|16554629 WD repeat domain 5 [Homo sapiens] 64 7e-10
gi|16554627 WD repeat domain 5 [Homo sapiens] 64 7e-10
gi|26665869 WD repeat domain 51B [Homo sapiens] 64 7e-10
gi|21071067 TBP-associated factor 5 [Homo sapiens] 63 1e-09
gi|16445438 bromodomain and WD repeat domain containing 1 isofor... 62 3e-09
gi|16445436 bromodomain and WD repeat domain containing 1 isofor... 62 3e-09
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 60 1e-08
>gi|21536485 HIR histone cell cycle regulation defective homolog A
[Homo sapiens]
Length = 1017
Score = 2033 bits (5268), Expect = 0.0
Identities = 1017/1017 (100%), Positives = 1017/1017 (100%)
Query: 1 MKLLKPTWVNHNGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIP 60
MKLLKPTWVNHNGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIP
Sbjct: 1 MKLLKPTWVNHNGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIP 60
Query: 61 KMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQ 120
KMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQ
Sbjct: 61 KMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQ 120
Query: 121 WRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGL 180
WRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGL
Sbjct: 121 WRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGL 180
Query: 181 TWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSA 240
TWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSA
Sbjct: 181 TWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSA 240
Query: 241 HAMNNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCC 300
HAMNNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCC
Sbjct: 241 HAMNNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCC 300
Query: 301 AVGSKDRSLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLDFSQD 360
AVGSKDRSLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLDFSQD
Sbjct: 301 AVGSKDRSLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLDFSQD 360
Query: 361 ELGDPLSEEEKSRIHQSTYGKSLAIMTEAQLSTAVIENPEMLKYQRRQQQQQLDQKSAAT 420
ELGDPLSEEEKSRIHQSTYGKSLAIMTEAQLSTAVIENPEMLKYQRRQQQQQLDQKSAAT
Sbjct: 361 ELGDPLSEEEKSRIHQSTYGKSLAIMTEAQLSTAVIENPEMLKYQRRQQQQQLDQKSAAT 420
Query: 421 REMGSATSVAGVVNGESLEDIRKNLLKKQVETRTADGRRRITPLCIAQLDTGDFSTAFFN 480
REMGSATSVAGVVNGESLEDIRKNLLKKQVETRTADGRRRITPLCIAQLDTGDFSTAFFN
Sbjct: 421 REMGSATSVAGVVNGESLEDIRKNLLKKQVETRTADGRRRITPLCIAQLDTGDFSTAFFN 480
Query: 481 SIPLSGSLAGTMLSSHSSPQLLPLDSSTPNSFGASKPCTEPVVAASARPAGDSVNKDSMN 540
SIPLSGSLAGTMLSSHSSPQLLPLDSSTPNSFGASKPCTEPVVAASARPAGDSVNKDSMN
Sbjct: 481 SIPLSGSLAGTMLSSHSSPQLLPLDSSTPNSFGASKPCTEPVVAASARPAGDSVNKDSMN 540
Query: 541 ATSTPAALSPSVLTTPSKIEPMKAFDSRFTERSKATPGAPALTSMTPTAVERLKEQNLVK 600
ATSTPAALSPSVLTTPSKIEPMKAFDSRFTERSKATPGAPALTSMTPTAVERLKEQNLVK
Sbjct: 541 ATSTPAALSPSVLTTPSKIEPMKAFDSRFTERSKATPGAPALTSMTPTAVERLKEQNLVK 600
Query: 601 ELRPRDLLESSSDSDEKVPLAKASSLSKRKLELEVETVEKKKKGRPRKDSRLMPVSLSVQ 660
ELRPRDLLESSSDSDEKVPLAKASSLSKRKLELEVETVEKKKKGRPRKDSRLMPVSLSVQ
Sbjct: 601 ELRPRDLLESSSDSDEKVPLAKASSLSKRKLELEVETVEKKKKGRPRKDSRLMPVSLSVQ 660
Query: 661 SPAALTAEKEAMCLSAPALALKLPIPSPQRAFTLQVSSDPSMYIEVENEVTVVGGVKLSR 720
SPAALTAEKEAMCLSAPALALKLPIPSPQRAFTLQVSSDPSMYIEVENEVTVVGGVKLSR
Sbjct: 661 SPAALTAEKEAMCLSAPALALKLPIPSPQRAFTLQVSSDPSMYIEVENEVTVVGGVKLSR 720
Query: 721 LKCNREGKEWETVLTSRILTAAGSCDVVCVACEKRMLSVFSTCGRRLLSPILLPSPISTL 780
LKCNREGKEWETVLTSRILTAAGSCDVVCVACEKRMLSVFSTCGRRLLSPILLPSPISTL
Sbjct: 721 LKCNREGKEWETVLTSRILTAAGSCDVVCVACEKRMLSVFSTCGRRLLSPILLPSPISTL 780
Query: 781 HCTGSYVMALTAAATLSVWDVHRQVVVVKEESLHSILAGSDMTVSQILLTQHGIPVMNLS 840
HCTGSYVMALTAAATLSVWDVHRQVVVVKEESLHSILAGSDMTVSQILLTQHGIPVMNLS
Sbjct: 781 HCTGSYVMALTAAATLSVWDVHRQVVVVKEESLHSILAGSDMTVSQILLTQHGIPVMNLS 840
Query: 841 DGKAYCFNPSLSTWNLVSDKQDSLAQCADFRSSLPSQDAMLCSGPLAIIQGRTSNSGRQA 900
DGKAYCFNPSLSTWNLVSDKQDSLAQCADFRSSLPSQDAMLCSGPLAIIQGRTSNSGRQA
Sbjct: 841 DGKAYCFNPSLSTWNLVSDKQDSLAQCADFRSSLPSQDAMLCSGPLAIIQGRTSNSGRQA 900
Query: 901 ARLFSVPHVVQQETTLAYLENQVAAALTLQSSHEYRHWLLVYARYLVNEGFEYRLREICK 960
ARLFSVPHVVQQETTLAYLENQVAAALTLQSSHEYRHWLLVYARYLVNEGFEYRLREICK
Sbjct: 901 ARLFSVPHVVQQETTLAYLENQVAAALTLQSSHEYRHWLLVYARYLVNEGFEYRLREICK 960
Query: 961 DLLGPVHYSTGSQWESTVVGLRKRELLKELLPVIGQNLRFQRLFTECQEQLDILRDK 1017
DLLGPVHYSTGSQWESTVVGLRKRELLKELLPVIGQNLRFQRLFTECQEQLDILRDK
Sbjct: 961 DLLGPVHYSTGSQWESTVVGLRKRELLKELLPVIGQNLRFQRLFTECQEQLDILRDK 1017
>gi|4885105 chromatin assembly factor 1 subunit B [Homo sapiens]
Length = 559
Score = 148 bits (373), Expect = 3e-35
Identities = 113/394 (28%), Positives = 182/394 (46%), Gaps = 32/394 (8%)
Query: 1 MKLLKPTWVNHNGKPIFSVDIHPD--GTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDEN 58
MK++ HN +P++S+D G G D+ V IW + E +
Sbjct: 1 MKVITCEIAWHNKEPVYSLDFQHGTAGRIHRLASAGVDTN-VRIWKV-----EKGPDGKA 54
Query: 59 IPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLA-- 116
I + L + H VN VR+S +G LASGGDD +I++WK P + A
Sbjct: 55 IVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQL 114
Query: 117 NVEQWRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGL 176
N E W V LR H DV D+ W+ +AS SVDNT +IW+ K +I + H
Sbjct: 115 NKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKI-SIFNEHKSY 173
Query: 177 VKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGG--------------- 221
V+G+TWDP+G+Y+A+ + DR L+V+ ++ +++K G
Sbjct: 174 VQGVTWDPLGQYVATLSCDRVLRVYSIQKKRVAFNVSKMLSGIGAEGEARSYRMFHDDSM 233
Query: 222 TTHVLRLSWSPDGHYLVSAHAMNNSGP----TAQIIEREGWKTNMDFVG-HRKAVTVVKF 276
+ RLS++PDG L++ SG T + R+ K + + KA V+
Sbjct: 234 KSFFRRLSFTPDGSLLLTPAGCVESGENVMNTTYVFSRKNLKRPIAHLPCPGKATLAVRC 293
Query: 277 NPKIFKKKQKNGSSAK-PSCPYCCCAVGSKDRSLSVWLTCLKRPLVVIHELFDKSIMDIS 335
P F+ + + + S PY + + S+ ++ T P + + ++ DIS
Sbjct: 294 CPVYFELRPVVETGVELMSLPYRLVFAVASEDSVLLYDTQQSFPFGYVSNIHYHTLSDIS 353
Query: 336 WTLNGLGILVCSMDGSVAFLDFSQDELGDPLSEE 369
W+ +G + + S DG +F+ F +DELG PL E+
Sbjct: 354 WSSDGAFLAISSTDGYCSFVTFEKDELGIPLKEK 387
>gi|4757988 WD repeat domain 39 [Homo sapiens]
Length = 339
Score = 82.4 bits (202), Expect = 2e-15
Identities = 47/150 (31%), Positives = 79/150 (52%), Gaps = 17/150 (11%)
Query: 54 EKDENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSG 113
+K+++ + + ++ H V V W+ SG LA+ DK + VW+
Sbjct: 89 KKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE--------------- 133
Query: 114 KLANVEQWRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEIL-ATLRG 172
+ +++ CVS+L +H+ DV V W P LAS S D+TV ++ + + ATL G
Sbjct: 134 -VDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEG 192
Query: 173 HSGLVKGLTWDPVGKYIASQADDRSLKVWR 202
H V L +DP G+ +AS +DDR++++WR
Sbjct: 193 HESTVWSLAFDPSGQRLASCSDDRTVRIWR 222
Score = 82.0 bits (201), Expect = 3e-15
Identities = 84/309 (27%), Positives = 119/309 (38%), Gaps = 66/309 (21%)
Query: 78 WSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSIL-RNHSGDVMD 136
W+ +G LAS G D+ I +W G+ G + W C S+L H V
Sbjct: 24 WNPAGTLLASCGGDRRIRIW------------GTEG-----DSWICKSVLSEGHQRTVRK 66
Query: 137 VAWSPHDAWLASCSVDNTVVIW--NAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQAD 194
VAWSP +LAS S D T IW N F E + TL GH VK + W P G +A+ +
Sbjct: 67 VAWSPCGNYLASASFDATTCIWKKNQDDF-ECVTTLEGHENEVKSVAWAPSGNLLATCSR 125
Query: 195 DRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQII- 253
D+S+ VW +D + E + T V + W P L SA + T ++
Sbjct: 126 DKSVWVWE-VDEEDEYECVSVLN--SHTQDVKHVVWHPSQELLASA----SYDDTVKLYR 178
Query: 254 -EREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCCAVGSKDRSLSVW 312
E + W GH V + F+P SC S DR++ +W
Sbjct: 179 EEEDDWVCCATLEGHESTVWSLAFDP---------SGQRLASC--------SDDRTVRIW 221
Query: 313 LTCLK---------------RPLVVIHELFDKSIMDISW-TLNGLGILVCSMDGSVAFLD 356
L + + + ++I DI+W L G C G A
Sbjct: 222 RQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATAC---GDDAIRV 278
Query: 357 FSQDELGDP 365
F +D DP
Sbjct: 279 FQEDPNSDP 287
Score = 75.9 bits (185), Expect = 2e-13
Identities = 62/222 (27%), Positives = 96/222 (43%), Gaps = 39/222 (17%)
Query: 22 HPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLACVNCVRWSNS 81
+P GT A+ G + ++ IW E D I K + + H V V WS
Sbjct: 25 NPAGTLLASCGGDR---RIRIWGT--------EGDSWICKSVLS-EGHQRTVRKVAWSPC 72
Query: 82 GMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHSGDVMDVAWSP 141
G YLAS D +WK+ N + + CV+ L H +V VAW+P
Sbjct: 73 GNYLASASFDATTCIWKK-----------------NQDDFECVTTLEGHENEVKSVAWAP 115
Query: 142 HDAWLASCSVDNTVVIWNAVKFP--EILATLRGHSGLVKGLTWDPVGKYIASQADDRSLK 199
LA+CS D +V +W + E ++ L H+ VK + W P + +AS + D ++K
Sbjct: 116 SGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVK 175
Query: 200 VWRTL--DWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVS 239
++R DW ++ G + V L++ P G L S
Sbjct: 176 LYREEEDDWVCCATLE------GHESTVWSLAFDPSGQRLAS 211
Score = 52.4 bits (124), Expect = 2e-06
Identities = 30/105 (28%), Positives = 47/105 (44%), Gaps = 6/105 (5%)
Query: 137 VAWSPHDAWLASCSVDNTVVIWNAVKFPEILATL--RGHSGLVKGLTWDPVGKYIASQAD 194
+AW+P LASC D + IW I ++ GH V+ + W P G Y+AS +
Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
Query: 195 DRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVS 239
D + +W+ E T G V ++W+P G+ L +
Sbjct: 82 DATTCIWKKNQDDFECVTTLE----GHENEVKSVAWAPSGNLLAT 122
Score = 44.3 bits (103), Expect = 6e-04
Identities = 43/184 (23%), Positives = 77/184 (41%), Gaps = 25/184 (13%)
Query: 39 KVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLACVNC---------VRWSNSGMYLASGG 89
K V+W+ S L D+ + + D+ + C + + SG LAS
Sbjct: 154 KHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCS 213
Query: 90 DDKLIMVWKRATYI-GPSTVFGSSGKLANVEQWRCVSILRN-HSGDVMDVAWSPHDAWLA 147
DD+ + +W++ Y+ G SG + W+C+ L HS + D+AW LA
Sbjct: 214 DDRTVRIWRQ--YLPGNEQGVACSG---SDPSWKCICTLSGFHSRTIYDIAWCQLTGALA 268
Query: 148 SCSVDNTVVIW-----NAVKFPEILATL---RGHSGLVKGLTWDPVGK-YIASQADDRSL 198
+ D+ + ++ + + P T + HS V + W+P +AS +DD +
Sbjct: 269 TACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEV 328
Query: 199 KVWR 202
W+
Sbjct: 329 AFWK 332
Score = 42.7 bits (99), Expect = 0.002
Identities = 33/106 (31%), Positives = 47/106 (44%), Gaps = 19/106 (17%)
Query: 180 LTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVS 239
L W+P G +AS DR +++W T + ++ I K G V +++WSP G+YL S
Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGT---EGDSWICKSVLSEGHQRTVRKVAWSPCGNYLAS 78
Query: 240 AHAMNNSGPTAQIIEREGWKTNMD-------FVGHRKAVTVVKFNP 278
A + T I WK N D GH V V + P
Sbjct: 79 A----SFDATTCI-----WKKNQDDFECVTTLEGHENEVKSVAWAP 115
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 74.7 bits (182), Expect = 4e-13
Identities = 62/256 (24%), Positives = 102/256 (39%), Gaps = 50/256 (19%)
Query: 18 SVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLACVNCVR 77
SV DG F T D V +W + K L + H+ V C +
Sbjct: 70 SVHFCSDGQSFVTAS---DDKTVKVWAT------------HRQKFLFSLSQHINWVRCAK 114
Query: 78 WSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHSGDVMDV 137
+S G + S DDK + +W +++ CV H G V V
Sbjct: 115 FSPDGRLIVSASDDKTVKLWDKSSR-------------------ECVHSYCEHGGFVTYV 155
Query: 138 AWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRS 197
+ P +A+ +DNTV +W+ V+ +L + HS V GL++ P G Y+ + + D +
Sbjct: 156 DFHPSGTCIAAAGMDNTVKVWD-VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDST 214
Query: 198 LKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREG 257
LK+ ++ +L ++ G +++S G Y S G Q++
Sbjct: 215 LKILDLMEGRLLYTLH------GHQGPATTVAFSRTGEYFAS------GGSDEQVMV--- 259
Query: 258 WKTNMDFVGHRKAVTV 273
WK+N D V H + V
Sbjct: 260 WKSNFDIVDHGEVTKV 275
Score = 61.2 bits (147), Expect = 5e-09
Identities = 67/262 (25%), Positives = 102/262 (38%), Gaps = 48/262 (18%)
Query: 40 VVIWNMSPVLQEDDEKDENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKR 99
+++W+M P + H V CV +S SG LASG DK + +W
Sbjct: 5 LMVWHMKP------------QSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWV- 51
Query: 100 ATYIGPSTVF---------------GSSGKLAN----VEQW-----RCVSILRNHSGDVM 135
G STVF G S A+ V+ W + + L H V
Sbjct: 52 PNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVR 111
Query: 136 DVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADD 195
+SP + S S D TV +W+ E + + H G V + + P G IA+ D
Sbjct: 112 CAKFSPDGRLIVSASDDKTVKLWDK-SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMD 170
Query: 196 RSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIER 255
++KVW +L G LS+ P G+YL++A +S T +I++
Sbjct: 171 NTVKVWDVRTHRLLQHYQLHSAAVNG------LSFHPSGNYLITA----SSDSTLKILDL 220
Query: 256 EGWKTNMDFVGHRKAVTVVKFN 277
+ GH+ T V F+
Sbjct: 221 MEGRLLYTLHGHQGPATTVAFS 242
Score = 36.6 bits (83), Expect = 0.12
Identities = 22/70 (31%), Positives = 32/70 (45%), Gaps = 11/70 (15%)
Query: 61 KMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYI-----------GPSTVF 109
++L + H V +S +G Y ASGG D+ +MVWK I P+T+
Sbjct: 224 RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLA 283
Query: 110 GSSGKLANVE 119
S G L V+
Sbjct: 284 SSMGNLPEVD 293
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 74.7 bits (182), Expect = 4e-13
Identities = 62/256 (24%), Positives = 102/256 (39%), Gaps = 50/256 (19%)
Query: 18 SVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLACVNCVR 77
SV DG F T D V +W + K L + H+ V C +
Sbjct: 108 SVHFCSDGQSFVTAS---DDKTVKVWAT------------HRQKFLFSLSQHINWVRCAK 152
Query: 78 WSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHSGDVMDV 137
+S G + S DDK + +W +++ CV H G V V
Sbjct: 153 FSPDGRLIVSASDDKTVKLWDKSSR-------------------ECVHSYCEHGGFVTYV 193
Query: 138 AWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRS 197
+ P +A+ +DNTV +W+ V+ +L + HS V GL++ P G Y+ + + D +
Sbjct: 194 DFHPSGTCIAAAGMDNTVKVWD-VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDST 252
Query: 198 LKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREG 257
LK+ ++ +L ++ G +++S G Y S G Q++
Sbjct: 253 LKILDLMEGRLLYTLH------GHQGPATTVAFSRTGEYFAS------GGSDEQVMV--- 297
Query: 258 WKTNMDFVGHRKAVTV 273
WK+N D V H + V
Sbjct: 298 WKSNFDIVDHGEVTKV 313
Score = 66.2 bits (160), Expect = 1e-10
Identities = 73/306 (23%), Positives = 123/306 (40%), Gaps = 54/306 (17%)
Query: 60 PKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVE 119
P + H V CV +S + LASG D +MVW S + +G
Sbjct: 9 PSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKP---QSRAYRFTG------ 59
Query: 120 QWRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEI---LATLRGHSGL 176
H V V +SP LAS S D TV IW P + R H+
Sbjct: 60 ----------HKDAVTCVNFSPSGHLLASGSRDKTVRIW----VPNVKGESTVFRAHTAT 105
Query: 177 VKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHY 236
V+ + + G+ + +DD+++KVW T + S+++ + V +SPDG
Sbjct: 106 VRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHIN------WVRCAKFSPDGRL 159
Query: 237 LVSAHAMNNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCP 296
+VSA + T ++ ++ + + H VT V F+P +G+
Sbjct: 160 IVSA----SDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHP--------SGT------- 200
Query: 297 YCCCAVGSKDRSLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLD 356
C A D ++ VW R L+ ++L ++ +S+ +G ++ S D ++ LD
Sbjct: 201 --CIAAAGMDNTVKVWDVRTHR-LLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 257
Query: 357 FSQDEL 362
+ L
Sbjct: 258 LMEGRL 263
Score = 61.2 bits (147), Expect = 5e-09
Identities = 67/262 (25%), Positives = 102/262 (38%), Gaps = 48/262 (18%)
Query: 40 VVIWNMSPVLQEDDEKDENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKR 99
+++W+M P + H V CV +S SG LASG DK + +W
Sbjct: 43 LMVWHMKP------------QSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWV- 89
Query: 100 ATYIGPSTVF---------------GSSGKLAN----VEQW-----RCVSILRNHSGDVM 135
G STVF G S A+ V+ W + + L H V
Sbjct: 90 PNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVR 149
Query: 136 DVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADD 195
+SP + S S D TV +W+ E + + H G V + + P G IA+ D
Sbjct: 150 CAKFSPDGRLIVSASDDKTVKLWDK-SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMD 208
Query: 196 RSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIER 255
++KVW +L G LS+ P G+YL++A +S T +I++
Sbjct: 209 NTVKVWDVRTHRLLQHYQLHSAAVNG------LSFHPSGNYLITA----SSDSTLKILDL 258
Query: 256 EGWKTNMDFVGHRKAVTVVKFN 277
+ GH+ T V F+
Sbjct: 259 MEGRLLYTLHGHQGPATTVAFS 280
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 74.7 bits (182), Expect = 4e-13
Identities = 62/256 (24%), Positives = 102/256 (39%), Gaps = 50/256 (19%)
Query: 18 SVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLACVNCVR 77
SV DG F T D V +W + K L + H+ V C +
Sbjct: 108 SVHFCSDGQSFVTAS---DDKTVKVWAT------------HRQKFLFSLSQHINWVRCAK 152
Query: 78 WSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHSGDVMDV 137
+S G + S DDK + +W +++ CV H G V V
Sbjct: 153 FSPDGRLIVSASDDKTVKLWDKSSR-------------------ECVHSYCEHGGFVTYV 193
Query: 138 AWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRS 197
+ P +A+ +DNTV +W+ V+ +L + HS V GL++ P G Y+ + + D +
Sbjct: 194 DFHPSGTCIAAAGMDNTVKVWD-VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDST 252
Query: 198 LKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREG 257
LK+ ++ +L ++ G +++S G Y S G Q++
Sbjct: 253 LKILDLMEGRLLYTLH------GHQGPATTVAFSRTGEYFAS------GGSDEQVMV--- 297
Query: 258 WKTNMDFVGHRKAVTV 273
WK+N D V H + V
Sbjct: 298 WKSNFDIVDHGEVTKV 313
Score = 66.2 bits (160), Expect = 1e-10
Identities = 73/306 (23%), Positives = 123/306 (40%), Gaps = 54/306 (17%)
Query: 60 PKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVE 119
P + H V CV +S + LASG D +MVW S + +G
Sbjct: 9 PSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKP---QSRAYRFTG------ 59
Query: 120 QWRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEI---LATLRGHSGL 176
H V V +SP LAS S D TV IW P + R H+
Sbjct: 60 ----------HKDAVTCVNFSPSGHLLASGSRDKTVRIW----VPNVKGESTVFRAHTAT 105
Query: 177 VKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHY 236
V+ + + G+ + +DD+++KVW T + S+++ + V +SPDG
Sbjct: 106 VRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHIN------WVRCAKFSPDGRL 159
Query: 237 LVSAHAMNNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCP 296
+VSA + T ++ ++ + + H VT V F+P +G+
Sbjct: 160 IVSA----SDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHP--------SGT------- 200
Query: 297 YCCCAVGSKDRSLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLD 356
C A D ++ VW R L+ ++L ++ +S+ +G ++ S D ++ LD
Sbjct: 201 --CIAAAGMDNTVKVWDVRTHR-LLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 257
Query: 357 FSQDEL 362
+ L
Sbjct: 258 LMEGRL 263
Score = 61.2 bits (147), Expect = 5e-09
Identities = 67/262 (25%), Positives = 102/262 (38%), Gaps = 48/262 (18%)
Query: 40 VVIWNMSPVLQEDDEKDENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKR 99
+++W+M P + H V CV +S SG LASG DK + +W
Sbjct: 43 LMVWHMKP------------QSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWV- 89
Query: 100 ATYIGPSTVF---------------GSSGKLAN----VEQW-----RCVSILRNHSGDVM 135
G STVF G S A+ V+ W + + L H V
Sbjct: 90 PNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVR 149
Query: 136 DVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADD 195
+SP + S S D TV +W+ E + + H G V + + P G IA+ D
Sbjct: 150 CAKFSPDGRLIVSASDDKTVKLWDK-SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMD 208
Query: 196 RSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIER 255
++KVW +L G LS+ P G+YL++A +S T +I++
Sbjct: 209 NTVKVWDVRTHRLLQHYQLHSAAVNG------LSFHPSGNYLITA----SSDSTLKILDL 258
Query: 256 EGWKTNMDFVGHRKAVTVVKFN 277
+ GH+ T V F+
Sbjct: 259 MEGRLLYTLHGHQGPATTVAFS 280
Score = 36.6 bits (83), Expect = 0.12
Identities = 22/70 (31%), Positives = 32/70 (45%), Gaps = 11/70 (15%)
Query: 61 KMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYI-----------GPSTVF 109
++L + H V +S +G Y ASGG D+ +MVWK I P+T+
Sbjct: 262 RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLA 321
Query: 110 GSSGKLANVE 119
S G L V+
Sbjct: 322 SSMGNLPEVD 331
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 74.7 bits (182), Expect = 4e-13
Identities = 59/222 (26%), Positives = 101/222 (45%), Gaps = 31/222 (13%)
Query: 48 VLQEDDEKDENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATY----- 102
+L+E+D++D+N + + H V R+ L S +D I W ++
Sbjct: 320 ILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVL 379
Query: 103 ------------IGPSTVFGSSG------KLANVEQWRCVSILRNHSGDVMDVAWSPHDA 144
I P +++ +SG +L + ++ + I H DV V + P+
Sbjct: 380 YQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSN 439
Query: 145 WLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTL 204
+LA+ S D TV +W+A + + GH G V L + P GKY+AS +D+ LK+W
Sbjct: 440 YLATGSTDKTVRLWSAQQGNSV-RLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLA 498
Query: 205 DWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNS 246
L + G T ++ L++SPD + SA +M+NS
Sbjct: 499 SGTLYKELR------GHTDNITSLTFSPDSGLIASA-SMDNS 533
Score = 74.7 bits (182), Expect = 4e-13
Identities = 50/187 (26%), Positives = 84/187 (44%), Gaps = 35/187 (18%)
Query: 15 PIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLACVN 74
P++ +DI P FA+G + + +W+ D P + HLA V+
Sbjct: 386 PVWDLDISPYSLYFASGSHDRTAR---LWSF----------DRTYPLRIYA--GHLADVD 430
Query: 75 CVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHSGDV 134
CV++ + YLA+G DK + +W + +Q V + H G V
Sbjct: 431 CVKFHPNSNYLATGSTDKTVRLW-------------------SAQQGNSVRLFTGHRGPV 471
Query: 135 MDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQAD 194
+ +A+SP+ +LAS D + +W+ + LRGH+ + LT+ P IAS +
Sbjct: 472 LSLAFSPNGKYLASAGEDQRLKLWDLAS-GTLYKELRGHTDNITSLTFSPDSGLIASASM 530
Query: 195 DRSLKVW 201
D S++VW
Sbjct: 531 DNSVRVW 537
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 74.3 bits (181), Expect = 5e-13
Identities = 48/181 (26%), Positives = 80/181 (44%), Gaps = 30/181 (16%)
Query: 59 IPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANV 118
+ + ++ H V V +S +G YLASG D + W +T
Sbjct: 103 VTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLST---------------ET 147
Query: 119 EQWRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVK 178
+ C + H V+ ++WSP LAS + +++W+ ++ TL GHS +
Sbjct: 148 PHFTC----KGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWIT 203
Query: 179 GLTWDPVG-----KYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPD 233
GL+W+P+ +Y+AS + D S+++W T + E +T G T V L W D
Sbjct: 204 GLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILT------GHTQSVTCLRWGGD 257
Query: 234 G 234
G
Sbjct: 258 G 258
Score = 69.3 bits (168), Expect = 2e-11
Identities = 45/142 (31%), Positives = 67/142 (47%), Gaps = 20/142 (14%)
Query: 61 KMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQ 120
K L +M H A +N V +S +AS DK I +W G +GK
Sbjct: 363 KPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWD-----------GRTGKY----- 406
Query: 121 WRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGL 180
++ LR H V +AWS L S S D+T+ +W+ VK ++ L GH+ V +
Sbjct: 407 ---LASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWD-VKAQKLAMDLPGHADEVYAV 462
Query: 181 TWDPVGKYIASQADDRSLKVWR 202
W P G+ +AS D+ L++WR
Sbjct: 463 DWSPDGQRVASGGKDKCLRIWR 484
Score = 67.0 bits (162), Expect = 9e-11
Identities = 63/271 (23%), Positives = 105/271 (38%), Gaps = 53/271 (19%)
Query: 66 MDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVS 125
+ H V C+RW G+ L S D+ I VW+ + T+ G G N
Sbjct: 242 LTGHTQSVTCLRWGGDGL-LYSASQDRTIKVWRAHDGVLCRTLQGH-GHWVNTMALSTDY 299
Query: 126 ILRNHSGDVMDVAWSPHDAW------------------------LASCSVDNTVVIWNAV 161
LR + + + + +P D L S S D T+ +W+
Sbjct: 300 ALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPA 359
Query: 162 KFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGG 221
+ + L + GH L+ + + P + +AS + D+S+K+W + S+ G
Sbjct: 360 EDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLR------GH 413
Query: 222 TTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIF 281
V +++WS D LVS +S T ++ + + K MD GH V V ++P
Sbjct: 414 VAAVYQIAWSADSRLLVS----GSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSP--- 466
Query: 282 KKKQKNGSSAKPSCPYCCCAVGSKDRSLSVW 312
+G A G KD+ L +W
Sbjct: 467 -----DGQRV---------ASGGKDKCLRIW 483
Score = 62.4 bits (150), Expect = 2e-09
Identities = 47/152 (30%), Positives = 65/152 (42%), Gaps = 23/152 (15%)
Query: 168 ATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTH-VL 226
++L GHS V + + P GKY+AS + D +++ W + S P C G H VL
Sbjct: 108 SSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFW-------DLSTETPHFTCKGHRHWVL 160
Query: 227 RLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQK 286
+SWSPDG L S +G G + GH K +T + + P
Sbjct: 161 SISWSPDGRKLASG---CKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEP-------- 209
Query: 287 NGSSAKPSCPYCCCAVGSKDRSLSVWLTCLKR 318
A P C Y A SKD S+ +W T R
Sbjct: 210 --LHANPECRY--VASSSKDGSVRIWDTTAGR 237
Score = 40.0 bits (92), Expect = 0.011
Identities = 27/103 (26%), Positives = 38/103 (36%), Gaps = 19/103 (18%)
Query: 56 DENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKL 115
D K L + H+A V + WS L SG D + VW
Sbjct: 400 DGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVW------------------ 441
Query: 116 ANVEQWRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIW 158
+V+ + L H+ +V V WSP +AS D + IW
Sbjct: 442 -DVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 36.2 bits (82), Expect = 0.16
Identities = 16/44 (36%), Positives = 22/44 (50%)
Query: 56 DENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKR 99
D K+ + H V V WS G +ASGG DK + +W+R
Sbjct: 442 DVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR 485
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 73.2 bits (178), Expect = 1e-12
Identities = 83/350 (23%), Positives = 135/350 (38%), Gaps = 67/350 (19%)
Query: 12 NGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLA 71
+ K + S+D + +GT ATG G IW +D N+ L Q H
Sbjct: 236 SNKDVTSLDWNTNGTLLATGSY---DGFARIWT----------EDGNLASTLGQ---HKG 279
Query: 72 CVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHS 131
+ ++W+ G Y+ S G DK ++W T G+ + HS
Sbjct: 280 PIFALKWNRKGNYILSAGVDKTTIIWDAHT-----------GEAKQQFPF--------HS 320
Query: 132 GDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIAS 191
+DV W ++ ASCS D + + + + T +GH+ V + WDP G +AS
Sbjct: 321 APALDVDWQ-NNTTFASCSTDMCIHVCR-LGCDRPVKTFQGHTNEVNAIKWDPSGMLLAS 378
Query: 192 QADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAH-----AMNNS 246
+DD +LK+W + E I D + + WSP G + + A +
Sbjct: 379 CSDDMTLKIW---SMKQEVCI---HDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASF 432
Query: 247 GPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCCAVGSKD 306
T ++ + E H++ V V F+P +G A GS D
Sbjct: 433 DSTVRLWDIERGVCTHTLTKHQEPVYSVAFSP--------DGK---------YLASGSFD 475
Query: 307 RSLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLD 356
+ + +W T + +V I ++ W G + + DGSV LD
Sbjct: 476 KCVHIWNT--QSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLD 523
Score = 41.6 bits (96), Expect = 0.004
Identities = 37/129 (28%), Positives = 60/129 (46%), Gaps = 20/129 (15%)
Query: 125 SILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILAT---LR------GH-- 173
++LR H +V AW+P LAS S D+T IWN + +T LR GH
Sbjct: 175 TVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 234
Query: 174 --SGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWS 231
+ V L W+ G +A+ + D ++W T D L +++ + + L W+
Sbjct: 235 PSNKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQ------HKGPIFALKWN 287
Query: 232 PDGHYLVSA 240
G+Y++SA
Sbjct: 288 RKGNYILSA 296
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 73.2 bits (178), Expect = 1e-12
Identities = 83/350 (23%), Positives = 135/350 (38%), Gaps = 67/350 (19%)
Query: 12 NGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLA 71
+ K + S+D + +GT ATG G IW +D N+ L Q H
Sbjct: 236 SNKDVTSLDWNTNGTLLATGSY---DGFARIWT----------EDGNLASTLGQ---HKG 279
Query: 72 CVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHS 131
+ ++W+ G Y+ S G DK ++W T G+ + HS
Sbjct: 280 PIFALKWNRKGNYILSAGVDKTTIIWDAHT-----------GEAKQQFPF--------HS 320
Query: 132 GDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIAS 191
+DV W ++ ASCS D + + + + T +GH+ V + WDP G +AS
Sbjct: 321 APALDVDWQ-NNTTFASCSTDMCIHVCR-LGCDRPVKTFQGHTNEVNAIKWDPSGMLLAS 378
Query: 192 QADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAH-----AMNNS 246
+DD +LK+W + E I D + + WSP G + + A +
Sbjct: 379 CSDDMTLKIW---SMKQEVCI---HDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASF 432
Query: 247 GPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCCAVGSKD 306
T ++ + E H++ V V F+P +G A GS D
Sbjct: 433 DSTVRLWDIERGVCTHTLTKHQEPVYSVAFSP--------DGK---------YLASGSFD 475
Query: 307 RSLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLD 356
+ + +W T + +V I ++ W G + + DGSV LD
Sbjct: 476 KCVHIWNT--QSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLD 523
Score = 41.6 bits (96), Expect = 0.004
Identities = 37/129 (28%), Positives = 60/129 (46%), Gaps = 20/129 (15%)
Query: 125 SILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILAT---LR------GH-- 173
++LR H +V AW+P LAS S D+T IWN + +T LR GH
Sbjct: 175 TVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 234
Query: 174 --SGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWS 231
+ V L W+ G +A+ + D ++W T D L +++ + + L W+
Sbjct: 235 PSNKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQ------HKGPIFALKWN 287
Query: 232 PDGHYLVSA 240
G+Y++SA
Sbjct: 288 RKGNYILSA 296
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 73.2 bits (178), Expect = 1e-12
Identities = 83/350 (23%), Positives = 135/350 (38%), Gaps = 67/350 (19%)
Query: 12 NGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLA 71
+ K + S+D + +GT ATG G IW +D N+ L Q H
Sbjct: 287 SNKDVTSLDWNTNGTLLATGSY---DGFARIWT----------EDGNLASTLGQ---HKG 330
Query: 72 CVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHS 131
+ ++W+ G Y+ S G DK ++W T G+ + HS
Sbjct: 331 PIFALKWNRKGNYILSAGVDKTTIIWDAHT-----------GEAKQQFPF--------HS 371
Query: 132 GDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIAS 191
+DV W ++ ASCS D + + + + T +GH+ V + WDP G +AS
Sbjct: 372 APALDVDWQ-NNTTFASCSTDMCIHVCR-LGCDRPVKTFQGHTNEVNAIKWDPSGMLLAS 429
Query: 192 QADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAH-----AMNNS 246
+DD +LK+W + E I D + + WSP G + + A +
Sbjct: 430 CSDDMTLKIW---SMKQEVCI---HDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASF 483
Query: 247 GPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCCAVGSKD 306
T ++ + E H++ V V F+P +G A GS D
Sbjct: 484 DSTVRLWDIERGVCTHTLTKHQEPVYSVAFSP--------DGK---------YLASGSFD 526
Query: 307 RSLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLD 356
+ + +W T + +V I ++ W G + + DGSV LD
Sbjct: 527 KCVHIWNT--QSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLD 574
Score = 41.6 bits (96), Expect = 0.004
Identities = 37/129 (28%), Positives = 60/129 (46%), Gaps = 20/129 (15%)
Query: 125 SILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILAT---LR------GH-- 173
++LR H +V AW+P LAS S D+T IWN + +T LR GH
Sbjct: 226 TVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 285
Query: 174 --SGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWS 231
+ V L W+ G +A+ + D ++W T D L +++ + + L W+
Sbjct: 286 PSNKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQ------HKGPIFALKWN 338
Query: 232 PDGHYLVSA 240
G+Y++SA
Sbjct: 339 RKGNYILSA 347
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 73.2 bits (178), Expect = 1e-12
Identities = 83/350 (23%), Positives = 135/350 (38%), Gaps = 67/350 (19%)
Query: 12 NGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLA 71
+ K + S+D + +GT ATG G IW +D N+ L Q H
Sbjct: 287 SNKDVTSLDWNTNGTLLATGSY---DGFARIWT----------EDGNLASTLGQ---HKG 330
Query: 72 CVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHS 131
+ ++W+ G Y+ S G DK ++W T G+ + HS
Sbjct: 331 PIFALKWNRKGNYILSAGVDKTTIIWDAHT-----------GEAKQQFPF--------HS 371
Query: 132 GDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIAS 191
+DV W ++ ASCS D + + + + T +GH+ V + WDP G +AS
Sbjct: 372 APALDVDWQ-NNTTFASCSTDMCIHVCR-LGCDRPVKTFQGHTNEVNAIKWDPSGMLLAS 429
Query: 192 QADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAH-----AMNNS 246
+DD +LK+W + E I D + + WSP G + + A +
Sbjct: 430 CSDDMTLKIW---SMKQEVCI---HDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASF 483
Query: 247 GPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCCAVGSKD 306
T ++ + E H++ V V F+P +G A GS D
Sbjct: 484 DSTVRLWDIERGVCTHTLTKHQEPVYSVAFSP--------DGK---------YLASGSFD 526
Query: 307 RSLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLD 356
+ + +W T + +V I ++ W G + + DGSV LD
Sbjct: 527 KCVHIWNT--QSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLD 574
Score = 41.6 bits (96), Expect = 0.004
Identities = 37/129 (28%), Positives = 60/129 (46%), Gaps = 20/129 (15%)
Query: 125 SILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILAT---LR------GH-- 173
++LR H +V AW+P LAS S D+T IWN + +T LR GH
Sbjct: 226 TVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 285
Query: 174 --SGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWS 231
+ V L W+ G +A+ + D ++W T D L +++ + + L W+
Sbjct: 286 PSNKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQ------HKGPIFALKWN 338
Query: 232 PDGHYLVSA 240
G+Y++SA
Sbjct: 339 RKGNYILSA 347
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 72.0 bits (175), Expect = 3e-12
Identities = 79/346 (22%), Positives = 133/346 (38%), Gaps = 59/346 (17%)
Query: 12 NGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLA 71
+ K + S+D + +GT ATG G IW KD N+ L Q H
Sbjct: 224 SNKDVTSLDWNSEGTLLATGSY---DGFARIWT----------KDGNLASTLGQ---HKG 267
Query: 72 CVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHS 131
+ ++W+ G ++ S G DK ++W T G+ + HS
Sbjct: 268 PIFALKWNKKGNFILSAGVDKTTIIWDAHT-----------GEAKQQFPF--------HS 308
Query: 132 GDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIAS 191
+DV W ++ + ASCS D + + + + T +GH+ V + WDP G +AS
Sbjct: 309 APALDVDWQSNNTF-ASCSTDMCIHVCKLGQ-DRPIKTFQGHTNEVNAIKWDPTGNLLAS 366
Query: 192 QADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQ 251
+DD +LK+W + + + D + + WSP G + +A +
Sbjct: 367 CSDDMTLKIW---SMKQDNCV---HDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASF 420
Query: 252 IIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCCAVGSKDRSLSV 311
W + H T+ K ++ + P Y A GS D+ + +
Sbjct: 421 DSTVRLWDVDRGICIH----TLTKHQEPVY------SVAFSPDGRY--LASGSFDKCVHI 468
Query: 312 WLTCLKRPLVVIHELFDK-SIMDISWTLNGLGILVCSMDGSVAFLD 356
W T + ++H I ++ W G + + DGSV LD
Sbjct: 469 WNT---QTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVLD 511
Score = 39.7 bits (91), Expect = 0.015
Identities = 33/128 (25%), Positives = 55/128 (42%), Gaps = 20/128 (15%)
Query: 126 ILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPE------ILATLRGHSGL--- 176
+LR H +V AW+P LAS S D+T IWN + +L G
Sbjct: 164 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVP 223
Query: 177 ----VKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSP 232
V L W+ G +A+ + D ++W T D L +++ + + L W+
Sbjct: 224 SNKDVTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQ------HKGPIFALKWNK 276
Query: 233 DGHYLVSA 240
G++++SA
Sbjct: 277 KGNFILSA 284
Score = 32.7 bits (73), Expect = 1.8
Identities = 22/84 (26%), Positives = 32/84 (38%), Gaps = 8/84 (9%)
Query: 164 PEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDEC---G 220
P LRGH V W+PV +AS + D + ++W + S C G
Sbjct: 159 PNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREG 218
Query: 221 G-----TTHVLRLSWSPDGHYLVS 239
G V L W+ +G L +
Sbjct: 219 GQDVPSNKDVTSLDWNSEGTLLAT 242
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 70.9 bits (172), Expect = 6e-12
Identities = 58/232 (25%), Positives = 101/232 (43%), Gaps = 47/232 (20%)
Query: 81 SGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHSGDVMDVAWS 140
SG LA+GGDD + +W ++ + C+ L H+ V V +
Sbjct: 32 SGRLLATGGDDCRVNLW-------------------SINKPNCIMSLTGHTSPVESVRLN 72
Query: 141 PHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKV 200
+ + + S ++ +W+ ++ +IL TL GH + L + P G+++AS + D ++K+
Sbjct: 73 TPEELIVAGSQSGSIRVWD-LEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKL 131
Query: 201 WRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKT 260
W D + + + F G + V L +SPDG +L SA T ++ + K
Sbjct: 132 W---DIRRKGCV---FRYRGHSQAVRCLRFSPDGKWLASA----ADDHTVKLWDLTAGKM 181
Query: 261 NMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCCAVGSKDRSLSVW 312
+F GH V VV+F+P + A GS DR++ W
Sbjct: 182 MSEFPGHTGPVNVVEFHPNEY-----------------LLASGSSDRTIRFW 216
Score = 63.2 bits (152), Expect = 1e-09
Identities = 59/254 (23%), Positives = 103/254 (40%), Gaps = 45/254 (17%)
Query: 25 GTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLACVNCVRWSNSGMY 84
G ATGG D +V +W++ N P + + H + V VR +
Sbjct: 33 GRLLATGG---DDCRVNLWSI------------NKPNCIMSLTGHTSPVESVRLNTPEEL 77
Query: 85 LASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHSGDVMDVAWSPHDA 144
+ +G I VW ++E + + L H ++ + + P+
Sbjct: 78 IVAGSQSGSIRVW-------------------DLEAAKILRTLMGHKANICSLDFHPYGE 118
Query: 145 WLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTL 204
++AS S D + +W+ ++ + RGHS V+ L + P GK++AS ADD ++K+W
Sbjct: 119 FVASGSQDTNIKLWD-IRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLW--- 174
Query: 205 DWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDF 264
+ + K E G T + + YL+ A +S T + + E ++
Sbjct: 175 ----DLTAGKMMSEFPGHTGPVNVVEFHPNEYLL---ASGSSDRTIRFWDLEKFQVVSCI 227
Query: 265 VGHRKAVTVVKFNP 278
G V V FNP
Sbjct: 228 EGEPGPVRSVLFNP 241
Score = 60.8 bits (146), Expect = 6e-09
Identities = 54/200 (27%), Positives = 91/200 (45%), Gaps = 38/200 (19%)
Query: 2 KLLKPTWVNHNGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPK 61
K+L+ T + H I S+D HP G A+G Q + + +W D
Sbjct: 96 KILR-TLMGHKAN-ICSLDFHPYGEFVASGSQDTN---IKLW------------DIRRKG 138
Query: 62 MLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQW 121
+ + H V C+R+S G +LAS DD + +W ++GK+
Sbjct: 139 CVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDL-----------TAGKM------ 181
Query: 122 RCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLT 181
+S H+G V V + P++ LAS S D T+ W+ KF ++++ + G G V+ +
Sbjct: 182 --MSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKF-QVVSCIEGEPGPVRSVL 238
Query: 182 WDPVGKYIASQADDRSLKVW 201
++P G + S D SL+V+
Sbjct: 239 FNPDGCCLYSGCQD-SLRVY 257
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 69.3 bits (168), Expect = 2e-11
Identities = 80/350 (22%), Positives = 136/350 (38%), Gaps = 67/350 (19%)
Query: 12 NGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLA 71
+ K + S+D + DGT A G G IW ++ N+ L Q H
Sbjct: 234 SNKDVTSLDWNSDGTLLAMGSY---DGFARIWT----------ENGNLASTLGQ---HKG 277
Query: 72 CVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHS 131
+ ++W+ G Y+ S G DK ++W T G+ + HS
Sbjct: 278 PIFALKWNKKGNYVLSAGVDKTTIIWDAHT-----------GEAKQQFPF--------HS 318
Query: 132 GDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIAS 191
+DV W ++ ASCS D + + + + T +GH+ V + WDP G +AS
Sbjct: 319 APALDVDWQ-NNMTFASCSTDMCIHVCR-LGCDHPVKTFQGHTNEVNAIKWDPSGMLLAS 376
Query: 192 QADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAH-----AMNNS 246
+DD +LK+W + + + D + + + WSP G + + A +
Sbjct: 377 CSDDMTLKIW---SMKQDACV---HDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASF 430
Query: 247 GPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCCAVGSKD 306
T ++ + E + H++ V V F+P +G A GS D
Sbjct: 431 DSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSP--------DGK---------YLASGSFD 473
Query: 307 RSLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLD 356
+ + +W T + +V I ++ W G + + DGSV LD
Sbjct: 474 KYVHIWNT--QSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLD 521
Score = 38.9 bits (89), Expect = 0.025
Identities = 36/129 (27%), Positives = 59/129 (45%), Gaps = 20/129 (15%)
Query: 125 SILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILAT---LR------GH-- 173
++LR H +V AW+P LAS S D+T IWN + +T LR GH
Sbjct: 173 TVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 232
Query: 174 --SGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWS 231
+ V L W+ G +A + D ++W T + L +++ + + L W+
Sbjct: 233 PSNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQ------HKGPIFALKWN 285
Query: 232 PDGHYLVSA 240
G+Y++SA
Sbjct: 286 KKGNYVLSA 294
Score = 33.9 bits (76), Expect = 0.80
Identities = 31/128 (24%), Positives = 48/128 (37%), Gaps = 21/128 (16%)
Query: 164 PEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWR--------TLDWQLETSITKP 215
P LRGH V W+PV +AS + D + ++W + L I +
Sbjct: 169 PNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREG 228
Query: 216 FDECGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDFVG----HRKAV 271
+ V L W+ DG L AM + A+I W N + H+ +
Sbjct: 229 GHDVPSNKDVTSLDWNSDGTLL----AMGSYDGFARI-----WTENGNLASTLGQHKGPI 279
Query: 272 TVVKFNPK 279
+K+N K
Sbjct: 280 FALKWNKK 287
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 69.3 bits (168), Expect = 2e-11
Identities = 80/350 (22%), Positives = 136/350 (38%), Gaps = 67/350 (19%)
Query: 12 NGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLA 71
+ K + S+D + DGT A G G IW ++ N+ L Q H
Sbjct: 234 SNKDVTSLDWNSDGTLLAMGSY---DGFARIWT----------ENGNLASTLGQ---HKG 277
Query: 72 CVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHS 131
+ ++W+ G Y+ S G DK ++W T G+ + HS
Sbjct: 278 PIFALKWNKKGNYVLSAGVDKTTIIWDAHT-----------GEAKQQFPF--------HS 318
Query: 132 GDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIAS 191
+DV W ++ ASCS D + + + + T +GH+ V + WDP G +AS
Sbjct: 319 APALDVDWQ-NNMTFASCSTDMCIHVCR-LGCDHPVKTFQGHTNEVNAIKWDPSGMLLAS 376
Query: 192 QADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAH-----AMNNS 246
+DD +LK+W + + + D + + + WSP G + + A +
Sbjct: 377 CSDDMTLKIW---SMKQDACV---HDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASF 430
Query: 247 GPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCCAVGSKD 306
T ++ + E + H++ V V F+P +G A GS D
Sbjct: 431 DSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSP--------DGK---------YLASGSFD 473
Query: 307 RSLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLD 356
+ + +W T + +V I ++ W G + + DGSV LD
Sbjct: 474 KYVHIWNT--QSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLD 521
Score = 38.9 bits (89), Expect = 0.025
Identities = 36/129 (27%), Positives = 59/129 (45%), Gaps = 20/129 (15%)
Query: 125 SILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILAT---LR------GH-- 173
++LR H +V AW+P LAS S D+T IWN + +T LR GH
Sbjct: 173 TVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 232
Query: 174 --SGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWS 231
+ V L W+ G +A + D ++W T + L +++ + + L W+
Sbjct: 233 PSNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQ------HKGPIFALKWN 285
Query: 232 PDGHYLVSA 240
G+Y++SA
Sbjct: 286 KKGNYVLSA 294
Score = 33.9 bits (76), Expect = 0.80
Identities = 31/128 (24%), Positives = 48/128 (37%), Gaps = 21/128 (16%)
Query: 164 PEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWR--------TLDWQLETSITKP 215
P LRGH V W+PV +AS + D + ++W + L I +
Sbjct: 169 PNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREG 228
Query: 216 FDECGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDFVG----HRKAV 271
+ V L W+ DG L AM + A+I W N + H+ +
Sbjct: 229 GHDVPSNKDVTSLDWNSDGTLL----AMGSYDGFARI-----WTENGNLASTLGQHKGPI 279
Query: 272 TVVKFNPK 279
+K+N K
Sbjct: 280 FALKWNKK 287
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 69.3 bits (168), Expect = 2e-11
Identities = 80/350 (22%), Positives = 136/350 (38%), Gaps = 67/350 (19%)
Query: 12 NGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLA 71
+ K + S+D + DGT A G G IW ++ N+ L Q H
Sbjct: 234 SNKDVTSLDWNSDGTLLAMGSY---DGFARIWT----------ENGNLASTLGQ---HKG 277
Query: 72 CVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHS 131
+ ++W+ G Y+ S G DK ++W T G+ + HS
Sbjct: 278 PIFALKWNKKGNYVLSAGVDKTTIIWDAHT-----------GEAKQQFPF--------HS 318
Query: 132 GDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIAS 191
+DV W ++ ASCS D + + + + T +GH+ V + WDP G +AS
Sbjct: 319 APALDVDWQ-NNMTFASCSTDMCIHVCR-LGCDHPVKTFQGHTNEVNAIKWDPSGMLLAS 376
Query: 192 QADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAH-----AMNNS 246
+DD +LK+W + + + D + + + WSP G + + A +
Sbjct: 377 CSDDMTLKIW---SMKQDACV---HDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASF 430
Query: 247 GPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCCAVGSKD 306
T ++ + E + H++ V V F+P +G A GS D
Sbjct: 431 DSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSP--------DGK---------YLASGSFD 473
Query: 307 RSLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLD 356
+ + +W T + +V I ++ W G + + DGSV LD
Sbjct: 474 KYVHIWNT--QSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLD 521
Score = 38.9 bits (89), Expect = 0.025
Identities = 36/129 (27%), Positives = 59/129 (45%), Gaps = 20/129 (15%)
Query: 125 SILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILAT---LR------GH-- 173
++LR H +V AW+P LAS S D+T IWN + +T LR GH
Sbjct: 173 TVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 232
Query: 174 --SGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWS 231
+ V L W+ G +A + D ++W T + L +++ + + L W+
Sbjct: 233 PSNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQ------HKGPIFALKWN 285
Query: 232 PDGHYLVSA 240
G+Y++SA
Sbjct: 286 KKGNYVLSA 294
Score = 33.9 bits (76), Expect = 0.80
Identities = 31/128 (24%), Positives = 48/128 (37%), Gaps = 21/128 (16%)
Query: 164 PEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWR--------TLDWQLETSITKP 215
P LRGH V W+PV +AS + D + ++W + L I +
Sbjct: 169 PNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREG 228
Query: 216 FDECGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDFVG----HRKAV 271
+ V L W+ DG L AM + A+I W N + H+ +
Sbjct: 229 GHDVPSNKDVTSLDWNSDGTLL----AMGSYDGFARI-----WTENGNLASTLGQHKGPI 279
Query: 272 TVVKFNPK 279
+K+N K
Sbjct: 280 FALKWNKK 287
>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
Length = 193
Score = 69.3 bits (168), Expect = 2e-11
Identities = 45/142 (31%), Positives = 67/142 (47%), Gaps = 20/142 (14%)
Query: 61 KMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQ 120
K L +M H A +N V +S +AS DK I +W G +GK
Sbjct: 71 KPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWD-----------GRTGKY----- 114
Query: 121 WRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGL 180
++ LR H V +AWS L S S D+T+ +W+ VK ++ L GH+ V +
Sbjct: 115 ---LASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWD-VKAQKLAMDLPGHADEVYAV 170
Query: 181 TWDPVGKYIASQADDRSLKVWR 202
W P G+ +AS D+ L++WR
Sbjct: 171 DWSPDGQRVASGGKDKCLRIWR 192
Score = 57.4 bits (137), Expect = 7e-08
Identities = 43/167 (25%), Positives = 73/167 (43%), Gaps = 27/167 (16%)
Query: 146 LASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLD 205
L S S D T+ +W+ + + L + GH L+ + + P + +AS + D+S+K+W
Sbjct: 52 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRT 111
Query: 206 WQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDFV 265
+ S+ G V +++WS D LVS +S T ++ + + K MD
Sbjct: 112 GKYLASLR------GHVAAVYQIAWSADSRLLVS----GSSDSTLKVWDVKAQKLAMDLP 161
Query: 266 GHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCCAVGSKDRSLSVW 312
GH V V ++P +G A G KD+ L +W
Sbjct: 162 GHADEVYAVDWSP--------DGQRV---------ASGGKDKCLRIW 191
Score = 40.0 bits (92), Expect = 0.011
Identities = 27/103 (26%), Positives = 38/103 (36%), Gaps = 19/103 (18%)
Query: 56 DENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKL 115
D K L + H+A V + WS L SG D + VW
Sbjct: 108 DGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVW------------------ 149
Query: 116 ANVEQWRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIW 158
+V+ + L H+ +V V WSP +AS D + IW
Sbjct: 150 -DVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 191
Score = 36.2 bits (82), Expect = 0.16
Identities = 16/44 (36%), Positives = 22/44 (50%)
Query: 56 DENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKR 99
D K+ + H V V WS G +ASGG DK + +W+R
Sbjct: 150 DVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR 193
>gi|118402582 cell division cycle 20 [Homo sapiens]
Length = 499
Score = 68.6 bits (166), Expect = 3e-11
Identities = 54/174 (31%), Positives = 77/174 (44%), Gaps = 38/174 (21%)
Query: 66 MDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIG--------------------- 104
+ H V +RW+ G +LASGG+D L+ VW A G
Sbjct: 305 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 364
Query: 105 --PSTVFGSSG-------KLANVEQWRCVSILRNHSGDVMDVAWSPHDAWLASCS--VDN 153
S V + G ++ NV C+S + HS V + WSPH L S N
Sbjct: 365 PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKELISGHGFAQN 423
Query: 154 TVVIWNAVKFPEI--LATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLD 205
+VIW K+P + +A L+GH+ V LT P G +AS A D +L++WR +
Sbjct: 424 QLVIW---KYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFE 474
Score = 50.8 bits (120), Expect = 6e-06
Identities = 37/140 (26%), Positives = 64/140 (45%), Gaps = 23/140 (16%)
Query: 63 LCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWR 122
L QM+ ++ V W G YLA G + +W +V+Q +
Sbjct: 219 LLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLW-------------------DVQQQK 259
Query: 123 CVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEI-LATLRGHSGLVKGLT 181
+ + +HS V ++W+ +++ S + + + V+ E +ATL GHS V GL
Sbjct: 260 RLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLR 316
Query: 182 WDPVGKYIASQADDRSLKVW 201
W P G+++AS +D + VW
Sbjct: 317 WAPDGRHLASGGNDNLVNVW 336
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 67.8 bits (164), Expect = 5e-11
Identities = 41/138 (29%), Positives = 68/138 (49%), Gaps = 20/138 (14%)
Query: 64 CQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRC 123
C + H V+ V++S +G +LAS D+LI++W T++G
Sbjct: 35 CTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYG------------- 81
Query: 124 VSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWD 183
H+ ++ DVAWS + L S S D T+ +W+ V+ + L TL+GHS V ++
Sbjct: 82 ------HNLEISDVAWSSDSSRLVSASDDKTLKLWD-VRSGKCLKTLKGHSNYVFCCNFN 134
Query: 184 PVGKYIASQADDRSLKVW 201
P I S + D ++K+W
Sbjct: 135 PPSNLIISGSFDETVKIW 152
Score = 62.8 bits (151), Expect = 2e-09
Identities = 52/233 (22%), Positives = 96/233 (41%), Gaps = 28/233 (12%)
Query: 127 LRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVG 186
L H+ V V +SP+ WLAS S D ++IW A + TL GH+ + + W
Sbjct: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYD-GKYEKTLYGHNLEISDVAWSSDS 95
Query: 187 KYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNS 246
+ S +DD++LK+W + ++ G + +V +++P + ++S +
Sbjct: 96 SRLVSASDDKTLKLWDVRSGKCLKTLK------GHSNYVFCCNFNPPSNLIIS----GSF 145
Query: 247 GPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCCAVGSKD 306
T +I E + K H V+ V FN C GS D
Sbjct: 146 DETVKIWEVKTGKCLKTLSAHSDPVSAVHFN-----------------CSGSLIVSGSYD 188
Query: 307 RSLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLDFSQ 359
+W + L + + + + + ++ NG IL ++D ++ D+S+
Sbjct: 189 GLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSR 241
Score = 49.7 bits (117), Expect = 1e-05
Identities = 53/221 (23%), Positives = 87/221 (39%), Gaps = 39/221 (17%)
Query: 4 LKPTWVNHNGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKML 63
LK T V H + + SV P+G A+ + ++IW D K E
Sbjct: 33 LKCTLVGHT-EAVSSVKFSPNGEWLASSSADR---LIIIWGAY------DGKYEKT---- 78
Query: 64 CQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWK------------RATYI------GP 105
+ H ++ V WS+ L S DDK + +W + Y+ P
Sbjct: 79 --LYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPP 136
Query: 106 STV-----FGSSGKLANVEQWRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNA 160
S + F + K+ V+ +C+ L HS V V ++ + + S S D IW+A
Sbjct: 137 SNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDA 196
Query: 161 VKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVW 201
+ + + V + + P GKYI + D +LK+W
Sbjct: 197 ASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLW 237
Score = 48.5 bits (114), Expect = 3e-05
Identities = 44/171 (25%), Positives = 73/171 (42%), Gaps = 32/171 (18%)
Query: 61 KMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRAT------------------- 101
K L + H V+ V ++ SG + SG D L +W A+
Sbjct: 158 KCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVK 217
Query: 102 ------YIGPSTVFGSSGKLANVEQWRCVSILRNHSGDVMDVAWS---PHDAWLASCSVD 152
YI +T+ ++ KL + + RC+ H + + + W+ S S D
Sbjct: 218 FSPNGKYILTATL-DNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED 276
Query: 153 NTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQA--DDRSLKVW 201
N V IWN ++ EI+ L+GH+ +V P IAS A +D+++K+W
Sbjct: 277 NLVYIWN-LQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 65.9 bits (159), Expect = 2e-10
Identities = 67/297 (22%), Positives = 119/297 (40%), Gaps = 53/297 (17%)
Query: 11 HNGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHL 70
H G+ ++ HP+G+ A+ G + +++WN V + D + H
Sbjct: 65 HEGE-VYCCKFHPNGSTLASAGFDR---LILLWN---VYGDCDN--------YATLKGHS 109
Query: 71 ACVNCVRWSNSGMYLASGGDDKLIMVWKRAT--------------------YIGPSTVFG 110
V + ++ G L S DK + VW T GP V
Sbjct: 110 GAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCT 169
Query: 111 SSG----KLANVEQWRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEI 166
S KL ++ + + +N + V+ V ++ + S +DN + +W+ ++ ++
Sbjct: 170 GSDDGTVKLWDIRKKAAIQTFQN-TYQVLAVTFNDTSDQIISGGIDNDIKVWD-LRQNKL 227
Query: 167 LATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTH-- 224
T+RGH+ V GL+ G Y+ S A D +++VW + + K F G H
Sbjct: 228 TYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQ---GNVHNF 284
Query: 225 ---VLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNP 278
+LR SWSPDG S A ++ + + + GH ++ V F+P
Sbjct: 285 EKNLLRCSWSPDG----SKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHP 337
Score = 57.0 bits (136), Expect = 9e-08
Identities = 73/315 (23%), Positives = 119/315 (37%), Gaps = 80/315 (25%)
Query: 48 VLQEDDEKDENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPST 107
+LQ + ++ + + H V C ++ +G LAS G D+LI++W
Sbjct: 44 LLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLW---------N 94
Query: 108 VFGSSGKLANVEQWRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEIL 167
V+G A L+ HSG VM++ ++ + L S S D TV +W++ + E +
Sbjct: 95 VYGDCDNYAT---------LKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDS-ETGERV 144
Query: 168 ATLRGHSGLVK------------------------------------------GLTWDPV 185
L+GH+ V +T++
Sbjct: 145 KRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDT 204
Query: 186 GKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNN 245
I S D +KVW +L ++ G V LS S +G YL+S +AM+N
Sbjct: 205 SDQIISGGIDNDIKVWDLRQNKLTYTMR------GHADSVTGLSLSSEGSYLLS-NAMDN 257
Query: 246 SGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCCAVGSK 305
T ++ W F + V + + N F+K S + A GS
Sbjct: 258 ---TVRV-----WDVR-PFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSK---IAAGSA 305
Query: 306 DRSLSVWLTCLKRPL 320
DR + VW T +R L
Sbjct: 306 DRFVYVWDTTSRRIL 320
>gi|157739942 gemin 5 [Homo sapiens]
Length = 1508
Score = 65.5 bits (158), Expect = 2e-10
Identities = 47/152 (30%), Positives = 69/152 (45%), Gaps = 17/152 (11%)
Query: 61 KMLCQMDNHLACVNCVRWSNS-------GMYLASGGDDKLIMVWKRATYIGPSTVFGSSG 113
K++C + H VN + W + +ASG ++ +I V T I S
Sbjct: 569 KLICTIQQHHKLVNTISWHHEHGSQPELSYLMASGSNNAVIYVHNLKTVIESSP----ES 624
Query: 114 KLANVEQWRCVSILRNHSGDVMDVAWSPH-DAWLASCSVDNTVVIWNAVKFPEILATLRG 172
+ E +R +S H+ + VAWSPH D L S S D T +W+A++ E L RG
Sbjct: 625 PVTITEPYRTLS---GHTAKITSVAWSPHHDGRLVSASYDGTAQVWDALR-EEPLCNFRG 680
Query: 173 HSGLVKGLTWDPVG-KYIASQADDRSLKVWRT 203
H G + + W P+ I S ADD + W T
Sbjct: 681 HRGRLLCVAWSPLDPDCIYSGADDFCVHKWLT 712
Score = 31.6 bits (70), Expect = 4.0
Identities = 28/110 (25%), Positives = 46/110 (41%), Gaps = 18/110 (16%)
Query: 34 GQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKL 93
G ++ + + N+ V++ E I + + H A + V WS D +L
Sbjct: 603 GSNNAVIYVHNLKTVIESSPESPVTITEPYRTLSGHTAKITSVAWS-------PHHDGRL 655
Query: 94 IMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHSGDVMDVAWSPHD 143
+ A+Y G + V+ A E+ C R H G ++ VAWSP D
Sbjct: 656 V----SASYDGTAQVWD-----ALREEPLC--NFRGHRGRLLCVAWSPLD 694
>gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]
Length = 1336
Score = 64.7 bits (156), Expect = 4e-10
Identities = 85/414 (20%), Positives = 156/414 (37%), Gaps = 80/414 (19%)
Query: 15 PIFSVDIHPDGTKFATGGQGQDSGKVVIWN-----MSPVLQEDDEKDENIPKMLCQMDNH 69
P+F V P+G + TG SG+ +WN +LQ D
Sbjct: 121 PVFVVRWTPEGRRLVTGAS---SGEFTLWNGLTFNFETILQAHDSP-------------- 163
Query: 70 LACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRN 129
V + WS++ M++ + + W+ + NV+ ++
Sbjct: 164 ---VRAMTWSHNDMWMLTADHGGYVKYWQ--------------SNMNNVKMFQA------ 200
Query: 130 HSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYI 189
H + + ++SP D A+CS D TV IW+ ++ E LRGH VK + W P +
Sbjct: 201 HKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHE-ERILRGHGADVKCVDWHPTKGLV 259
Query: 190 ASQADD--RSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNSG 247
S + D + +K W Q ++ V+ + + +G++L++A +
Sbjct: 260 VSGSKDSQQPIKFWDPKTGQSLATLH------AHKNTVMEVKLNLNGNWLLTA----SRD 309
Query: 248 PTAQIIEREGWKTNMD-FVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCCAVGSKD 306
++ + K + F GH+K T V ++P G A G D
Sbjct: 310 HLCKLFDIRNLKEELQVFRGHKKEATAVAWHP------VHEGLFAS----------GGSD 353
Query: 307 RSLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLDFSQDELGDPL 366
SL W +++ + + + I ++W + LG ++CS ++++ GD +
Sbjct: 354 GSLLFWHVGVEKEVGGMEMAHEGMIWSLAW--HPLGHILCSGSNDHTSKFWTRNRPGDKM 411
Query: 367 SEEEKSRIHQSTYGKSLAIMTEAQLSTAVIEN---PEMLKYQRRQQQQQLDQKS 417
+ + + S AVI PE LK Q+Q D+ +
Sbjct: 412 RDRYNLNLLPGMSEDGVEYDDLEPNSLAVIPGMGIPEQLKLAMEQEQMGKDESN 465
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 63.9 bits (154), Expect = 7e-10
Identities = 61/224 (27%), Positives = 97/224 (43%), Gaps = 35/224 (15%)
Query: 69 HLACVNCVRWSNSGMYLASGGDDKLIMVWK----------RATYIGPSTVFGSSG----- 113
H V+ V++S +G +LAS DKLI +W +G S V SS
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103
Query: 114 --------KLANVEQWRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPE 165
K+ +V +C+ L+ HS V ++P + S S D +V IW+ VK +
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD-VKTGK 162
Query: 166 ILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQ-LETSITKPFDECGGTTH 224
L TL HS V + ++ G I S + D ++W T Q L+T I
Sbjct: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID------DDNPP 216
Query: 225 VLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDFVGHR 268
V + +SP+G Y+++A N T ++ + K + GH+
Sbjct: 217 VSFVKFSPNGKYILAATLDN----TLKLWDYSKGKCLKTYTGHK 256
Score = 60.5 bits (145), Expect = 8e-09
Identities = 54/235 (22%), Positives = 100/235 (42%), Gaps = 32/235 (13%)
Query: 127 LRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAV--KFPEILATLRGHSGLVKGLTWDP 184
L H+ V V +SP+ WLAS S D + IW A KF + T+ GH + + W
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK---TISGHKLGISDVAWSS 97
Query: 185 VGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMN 244
+ S +DD++LK+W + ++ G + +V +++P + +VS
Sbjct: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLK------GHSNYVFCCNFNPQSNLIVS----G 147
Query: 245 NSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCCAVGS 304
+ + +I + + K H V+ V FN ++GS S S
Sbjct: 148 SFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN--------RDGSLIVSS---------S 190
Query: 305 KDRSLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLDFSQ 359
D +W T + L + + + + + ++ NG IL ++D ++ D+S+
Sbjct: 191 YDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245
Score = 51.6 bits (122), Expect = 4e-06
Identities = 49/183 (26%), Positives = 78/183 (42%), Gaps = 38/183 (20%)
Query: 169 TLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRL 228
TL GH+ V + + P G+++AS + D+ +K+W D + E +I+ G + +
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS------GHKLGISDV 93
Query: 229 SWSPDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNG 288
+WS D + LVSA + T +I + K GH V FNP Q N
Sbjct: 94 AWSSDSNLLVSA----SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP------QSN- 142
Query: 289 SSAKPSCPYCCCAVGSKDRSLSVWLT----CLKR------PLVVIHELFDKSIMDISWTL 338
GS D S+ +W CLK P+ +H D S++ +S +
Sbjct: 143 ----------LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLI-VSSSY 191
Query: 339 NGL 341
+GL
Sbjct: 192 DGL 194
Score = 48.5 bits (114), Expect = 3e-05
Identities = 52/221 (23%), Positives = 84/221 (38%), Gaps = 39/221 (17%)
Query: 4 LKPTWVNHNGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKML 63
LK T H K + SV P+G A+ + + IW D K E
Sbjct: 37 LKFTLAGHT-KAVSSVKFSPNGEWLASSSADK---LIKIWGAY------DGKFEKT---- 82
Query: 64 CQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWK------------RATYI-----GP- 105
+ H ++ V WS+ L S DDK + +W + Y+ P
Sbjct: 83 --ISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ 140
Query: 106 -----STVFGSSGKLANVEQWRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNA 160
S F S ++ +V+ +C+ L HS V V ++ + + S S D IW+
Sbjct: 141 SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
Query: 161 VKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVW 201
+ + + V + + P GKYI + D +LK+W
Sbjct: 201 ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241
Score = 45.8 bits (107), Expect = 2e-04
Identities = 42/178 (23%), Positives = 74/178 (41%), Gaps = 32/178 (17%)
Query: 56 DENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRAT-------------- 101
D K L + H V+ V ++ G + S D L +W A+
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 216
Query: 102 -----------YIGPSTVFGSSGKLANVEQWRCVSILRNHSGDVMDVAWS---PHDAWLA 147
YI +T+ ++ KL + + +C+ H + + + W+
Sbjct: 217 VSFVKFSPNGKYILAATL-DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275
Query: 148 SCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQA--DDRSLKVWRT 203
S S DN V IWN ++ EI+ L+GH+ +V P IAS A +D+++K+W++
Sbjct: 276 SGSEDNLVYIWN-LQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 63.9 bits (154), Expect = 7e-10
Identities = 61/224 (27%), Positives = 97/224 (43%), Gaps = 35/224 (15%)
Query: 69 HLACVNCVRWSNSGMYLASGGDDKLIMVWK----------RATYIGPSTVFGSSG----- 113
H V+ V++S +G +LAS DKLI +W +G S V SS
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103
Query: 114 --------KLANVEQWRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPE 165
K+ +V +C+ L+ HS V ++P + S S D +V IW+ VK +
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD-VKTGK 162
Query: 166 ILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQ-LETSITKPFDECGGTTH 224
L TL HS V + ++ G I S + D ++W T Q L+T I
Sbjct: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID------DDNPP 216
Query: 225 VLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDFVGHR 268
V + +SP+G Y+++A N T ++ + K + GH+
Sbjct: 217 VSFVKFSPNGKYILAATLDN----TLKLWDYSKGKCLKTYTGHK 256
Score = 60.5 bits (145), Expect = 8e-09
Identities = 54/235 (22%), Positives = 100/235 (42%), Gaps = 32/235 (13%)
Query: 127 LRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAV--KFPEILATLRGHSGLVKGLTWDP 184
L H+ V V +SP+ WLAS S D + IW A KF + T+ GH + + W
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK---TISGHKLGISDVAWSS 97
Query: 185 VGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMN 244
+ S +DD++LK+W + ++ G + +V +++P + +VS
Sbjct: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLK------GHSNYVFCCNFNPQSNLIVS----G 147
Query: 245 NSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCCAVGS 304
+ + +I + + K H V+ V FN ++GS S S
Sbjct: 148 SFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN--------RDGSLIVSS---------S 190
Query: 305 KDRSLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLDFSQ 359
D +W T + L + + + + + ++ NG IL ++D ++ D+S+
Sbjct: 191 YDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245
Score = 51.6 bits (122), Expect = 4e-06
Identities = 49/183 (26%), Positives = 78/183 (42%), Gaps = 38/183 (20%)
Query: 169 TLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRL 228
TL GH+ V + + P G+++AS + D+ +K+W D + E +I+ G + +
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS------GHKLGISDV 93
Query: 229 SWSPDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNG 288
+WS D + LVSA + T +I + K GH V FNP Q N
Sbjct: 94 AWSSDSNLLVSA----SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP------QSN- 142
Query: 289 SSAKPSCPYCCCAVGSKDRSLSVWLT----CLKR------PLVVIHELFDKSIMDISWTL 338
GS D S+ +W CLK P+ +H D S++ +S +
Sbjct: 143 ----------LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLI-VSSSY 191
Query: 339 NGL 341
+GL
Sbjct: 192 DGL 194
Score = 48.5 bits (114), Expect = 3e-05
Identities = 52/221 (23%), Positives = 84/221 (38%), Gaps = 39/221 (17%)
Query: 4 LKPTWVNHNGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKML 63
LK T H K + SV P+G A+ + + IW D K E
Sbjct: 37 LKFTLAGHT-KAVSSVKFSPNGEWLASSSADK---LIKIWGAY------DGKFEKT---- 82
Query: 64 CQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWK------------RATYI-----GP- 105
+ H ++ V WS+ L S DDK + +W + Y+ P
Sbjct: 83 --ISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ 140
Query: 106 -----STVFGSSGKLANVEQWRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNA 160
S F S ++ +V+ +C+ L HS V V ++ + + S S D IW+
Sbjct: 141 SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
Query: 161 VKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVW 201
+ + + V + + P GKYI + D +LK+W
Sbjct: 201 ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241
Score = 45.8 bits (107), Expect = 2e-04
Identities = 42/178 (23%), Positives = 74/178 (41%), Gaps = 32/178 (17%)
Query: 56 DENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRAT-------------- 101
D K L + H V+ V ++ G + S D L +W A+
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 216
Query: 102 -----------YIGPSTVFGSSGKLANVEQWRCVSILRNHSGDVMDVAWS---PHDAWLA 147
YI +T+ ++ KL + + +C+ H + + + W+
Sbjct: 217 VSFVKFSPNGKYILAATL-DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275
Query: 148 SCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQA--DDRSLKVWRT 203
S S DN V IWN ++ EI+ L+GH+ +V P IAS A +D+++K+W++
Sbjct: 276 SGSEDNLVYIWN-LQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 63.9 bits (154), Expect = 7e-10
Identities = 67/295 (22%), Positives = 122/295 (41%), Gaps = 50/295 (16%)
Query: 69 HLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILR 128
H A + + S +G LA+ D +M+W + G
Sbjct: 17 HKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVG------------------ 58
Query: 129 NHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKY 188
H V V +SPH LAS S D TV +W K + + + H+ V+ + + G++
Sbjct: 59 -HKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKF-SEFKAHTAPVRSVDFSADGQF 116
Query: 189 IASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLS-WSPDGHYLVSAHAMNNSG 247
+A+ ++D+S+KVW + S+ + TH +R + +SPDG +VS +
Sbjct: 117 LATASEDKSIKVWSMYRQRFLYSLYR-------HTHWVRCAKFSPDGRLIVSC----SED 165
Query: 248 PTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCCAVGSKDR 307
T +I + + +F V FNP +G+ C A D+
Sbjct: 166 KTIKIWDTTNKQCVNNFSDSVGFANFVDFNP--------SGT---------CIASAGSDQ 208
Query: 308 SLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLDFSQDEL 362
++ VW + + L+ +++ + IS+ +G ++ S DG++ LD + L
Sbjct: 209 TVKVWDVRVNK-LLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRL 262
Score = 60.8 bits (146), Expect = 6e-09
Identities = 54/212 (25%), Positives = 93/212 (43%), Gaps = 39/212 (18%)
Query: 15 PIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLACVN 74
P+ SVD DG AT + + + +W+M + L + H V
Sbjct: 104 PVRSVDFSADGQFLATASEDKS---IKVWSMYR------------QRFLYSLYRHTHWVR 148
Query: 75 CVRWSNSGMYLASGGDDKLIMVWKR---------------ATYI--GPS-TVFGSSGKLA 116
C ++S G + S +DK I +W A ++ PS T S+G
Sbjct: 149 CAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQ 208
Query: 117 NVEQW--RCVSILRN---HSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLR 171
V+ W R +L++ HSG V +++ P +L + S D T+ I + ++ ++ TL+
Sbjct: 209 TVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLE-GRLIYTLQ 267
Query: 172 GHSGLVKGLTWDPVGKYIASQADDRSLKVWRT 203
GH+G V +++ G+ AS D + +WRT
Sbjct: 268 GHTGPVFTVSFSKGGELFASGGADTQVLLWRT 299
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 63.2 bits (152), Expect = 1e-09
Identities = 35/133 (26%), Positives = 66/133 (49%), Gaps = 20/133 (15%)
Query: 69 HLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILR 128
HLA VNC R+ + Y+A+G D+ + +W +V CV I
Sbjct: 626 HLADVNCTRFHPNSNYVATGSADRTVRLW-------------------DVLNGNCVRIFT 666
Query: 129 NHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKY 188
H G + + +SP+ +LA+ + D V++W+ + ++ L+GH+ V L + G+
Sbjct: 667 GHKGPIHSLTFSPNGRFLATGATDGRVLLWD-IGHGLMVGELKGHTDTVCSLRFSRDGEI 725
Query: 189 IASQADDRSLKVW 201
+AS + D ++++W
Sbjct: 726 LASGSMDNTVRLW 738
Score = 57.8 bits (138), Expect = 5e-08
Identities = 55/236 (23%), Positives = 94/236 (39%), Gaps = 43/236 (18%)
Query: 11 HNGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHL 70
H+G P++ PD + + G V +W++ K N P
Sbjct: 542 HSG-PVYGASFSPDRNYLLSSSE---DGTVRLWSLQTFTCLVGYKGHNYP---------- 587
Query: 71 ACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNH 130
V ++S G Y SGG D++ +W + ++ + I H
Sbjct: 588 --VWDTQFSPYGYYFVSGGHDRVARLWA-------------------TDHYQPLRIFAGH 626
Query: 131 SGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIA 190
DV + P+ ++A+ S D TV +W+ + + GH G + LT+ P G+++A
Sbjct: 627 LADVNCTRFHPNSNYVATGSADRTVRLWDVLN-GNCVRIFTGHKGPIHSLTFSPNGRFLA 685
Query: 191 SQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNS 246
+ A D + +W + L K G T V L +S DG L S +M+N+
Sbjct: 686 TGATDGRVLLW-DIGHGLMVGELK-----GHTDTVCSLRFSRDGEILASG-SMDNT 734
Score = 48.9 bits (115), Expect = 2e-05
Identities = 29/84 (34%), Positives = 41/84 (48%), Gaps = 1/84 (1%)
Query: 124 VSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWD 183
+ IL HSG V ++SP +L S S D TV +W+ F L +GH+ V +
Sbjct: 536 LKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTF-TCLVGYKGHNYPVWDTQFS 594
Query: 184 PVGKYIASQADDRSLKVWRTLDWQ 207
P G Y S DR ++W T +Q
Sbjct: 595 PYGYYFVSGGHDRVARLWATDHYQ 618
Score = 38.5 bits (88), Expect = 0.032
Identities = 26/90 (28%), Positives = 41/90 (45%), Gaps = 16/90 (17%)
Query: 8 WVNHNGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMD 67
+ H G PI S+ P+G ATG G+V++W++ L M+ ++
Sbjct: 665 FTGHKG-PIHSLTFSPNGRFLATGAT---DGRVLLWDIGHGL------------MVGELK 708
Query: 68 NHLACVNCVRWSNSGMYLASGGDDKLIMVW 97
H V +R+S G LASG D + +W
Sbjct: 709 GHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
>gi|16445438 bromodomain and WD repeat domain containing 1 isoform B
[Homo sapiens]
Length = 2269
Score = 62.0 bits (149), Expect = 3e-09
Identities = 42/154 (27%), Positives = 76/154 (49%), Gaps = 27/154 (17%)
Query: 61 KMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQ 120
KM ++ HL+ V CV + +G + +G DD L+ +W +T+ G
Sbjct: 177 KMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIW--STHNG---------------- 218
Query: 121 WRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGL 180
R +S LR HS ++ D+A + + +A+ S D + +W ++ +A L+GH+G + L
Sbjct: 219 -RLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVW-CLRTCAPVAVLQGHTGSITSL 276
Query: 181 TWDPVGK----YIASQADDRSLKVWRTLDWQLET 210
+ P+ K Y+ S D ++ W+ W LE+
Sbjct: 277 QFSPMAKGSQRYMVSTGADGTVCFWQ---WDLES 307
Score = 44.7 bits (104), Expect = 5e-04
Identities = 43/186 (23%), Positives = 83/186 (44%), Gaps = 22/186 (11%)
Query: 60 PKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWK------RATYIGPSTVFGSSG 113
P+ + ++++H V+ +++ N+G SG D +W+ R+ + +T SG
Sbjct: 358 PEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRI--SG 415
Query: 114 KLANVEQWRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGH 173
L++ E+ R V +AW+ +D+ + + D+ + +WN+ ++L L GH
Sbjct: 416 DLSSEEE-------RFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYT-GQLLHNLMGH 467
Query: 174 SGLVKGLTWDPV-GKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTH--VLRLSW 230
+ V L P + + S D S+ +W D T + F+ G H V +
Sbjct: 468 ADEVFVLETHPFDSRIMLSAGHDGSIFIW---DITKGTKMKHYFNMIEGQGHGAVFDCKF 524
Query: 231 SPDGHY 236
S DG +
Sbjct: 525 SQDGQH 530
Score = 32.0 bits (71), Expect = 3.0
Identities = 37/159 (23%), Positives = 63/159 (39%), Gaps = 32/159 (20%)
Query: 75 CVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHSGDV 134
C +S GM+LA+G D +I R ++G F + K+A +E +H+ V
Sbjct: 329 CSSFSVGGMFLATGSTDHVI----RMYFLG----FEAPEKIAELE---------SHTDKV 371
Query: 135 MDVAWSPHDAWLASCSVDNTVVIW--NAVKFPEILATL-------------RGHSGLVKG 179
+ + + S S D T IW +++ IL + R V
Sbjct: 372 DSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTM 431
Query: 180 LTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDE 218
+ W+ + + +D LKVW + QL ++ DE
Sbjct: 432 IAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADE 470
>gi|16445436 bromodomain and WD repeat domain containing 1 isoform A
[Homo sapiens]
Length = 2320
Score = 62.0 bits (149), Expect = 3e-09
Identities = 42/154 (27%), Positives = 76/154 (49%), Gaps = 27/154 (17%)
Query: 61 KMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQ 120
KM ++ HL+ V CV + +G + +G DD L+ +W +T+ G
Sbjct: 177 KMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIW--STHNG---------------- 218
Query: 121 WRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGL 180
R +S LR HS ++ D+A + + +A+ S D + +W ++ +A L+GH+G + L
Sbjct: 219 -RLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVW-CLRTCAPVAVLQGHTGSITSL 276
Query: 181 TWDPVGK----YIASQADDRSLKVWRTLDWQLET 210
+ P+ K Y+ S D ++ W+ W LE+
Sbjct: 277 QFSPMAKGSQRYMVSTGADGTVCFWQ---WDLES 307
Score = 44.7 bits (104), Expect = 5e-04
Identities = 43/186 (23%), Positives = 83/186 (44%), Gaps = 22/186 (11%)
Query: 60 PKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWK------RATYIGPSTVFGSSG 113
P+ + ++++H V+ +++ N+G SG D +W+ R+ + +T SG
Sbjct: 358 PEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRI--SG 415
Query: 114 KLANVEQWRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGH 173
L++ E+ R V +AW+ +D+ + + D+ + +WN+ ++L L GH
Sbjct: 416 DLSSEEE-------RFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYT-GQLLHNLMGH 467
Query: 174 SGLVKGLTWDPV-GKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTH--VLRLSW 230
+ V L P + + S D S+ +W D T + F+ G H V +
Sbjct: 468 ADEVFVLETHPFDSRIMLSAGHDGSIFIW---DITKGTKMKHYFNMIEGQGHGAVFDCKF 524
Query: 231 SPDGHY 236
S DG +
Sbjct: 525 SQDGQH 530
Score = 32.0 bits (71), Expect = 3.0
Identities = 37/159 (23%), Positives = 63/159 (39%), Gaps = 32/159 (20%)
Query: 75 CVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHSGDV 134
C +S GM+LA+G D +I R ++G F + K+A +E +H+ V
Sbjct: 329 CSSFSVGGMFLATGSTDHVI----RMYFLG----FEAPEKIAELE---------SHTDKV 371
Query: 135 MDVAWSPHDAWLASCSVDNTVVIW--NAVKFPEILATL-------------RGHSGLVKG 179
+ + + S S D T IW +++ IL + R V
Sbjct: 372 DSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTM 431
Query: 180 LTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDE 218
+ W+ + + +D LKVW + QL ++ DE
Sbjct: 432 IAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADE 470
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 60.1 bits (144), Expect = 1e-08
Identities = 49/187 (26%), Positives = 80/187 (42%), Gaps = 36/187 (19%)
Query: 16 IFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLACVNC 75
++ + H DG+ TGG G+V W++ + + ++ HL +
Sbjct: 368 VYDIAFHQDGSLAGTGGLDA-FGRV--WDL------------RTGRCIMFLEGHLKEIYG 412
Query: 76 VRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHSGDVM 135
+ +S +G ++A+G D VW ++ Q RCV + H V
Sbjct: 413 INFSPNGYHIATGSGDNTCKVW-------------------DLRQRRCVYTIPAHQNLVT 453
Query: 136 DVAWSP-HDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQAD 194
V + P H +L + + DNT IW + L TL GH G V GL G+ IA+ +
Sbjct: 454 GVKFEPIHGNFLLTGAYDNTAKIWTHPGWSP-LKTLAGHEGKVMGLDISSDGQLIATCSY 512
Query: 195 DRSLKVW 201
DR+ K+W
Sbjct: 513 DRTFKLW 519
Score = 53.9 bits (128), Expect = 7e-07
Identities = 49/226 (21%), Positives = 93/226 (41%), Gaps = 43/226 (19%)
Query: 38 GKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVW 97
G V +W++ + DE + ++ H V V W SG +L + D+ +W
Sbjct: 303 GSVKLWSL--------DSDEPV----ADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLW 350
Query: 98 ----------KRATYIGPSTV-FGSSGKLA------------NVEQWRCVSILRNHSGDV 134
+ +G + F G LA ++ RC+ L H ++
Sbjct: 351 DLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEI 410
Query: 135 MDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPV-GKYIASQA 193
+ +SP+ +A+ S DNT +W+ ++ + T+ H LV G+ ++P+ G ++ + A
Sbjct: 411 YGINFSPNGYHIATGSGDNTCKVWD-LRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGA 469
Query: 194 DDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVS 239
D + K+W W ++ G V+ L S DG + +
Sbjct: 470 YDNTAKIWTHPGWSPLKTL------AGHEGKVMGLDISSDGQLIAT 509
Score = 52.0 bits (123), Expect = 3e-06
Identities = 50/207 (24%), Positives = 86/207 (41%), Gaps = 36/207 (17%)
Query: 114 KLANVEQWRCVSILRNHSGDV--------MDVAWSPHDAWLASCSVDNTVVIWNAVKFPE 165
KL +V + LR H+ +V V+ P D LASC+ D +V +W+ + E
Sbjct: 256 KLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWS-LDSDE 314
Query: 166 ILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHV 225
+A + GH+ V + W P G+++ + DRS WR D + + I + G + V
Sbjct: 315 PVADIEGHTVRVARVMWHPSGRFLGTTCYDRS---WRLWDLEAQEEI---LHQEGHSMGV 368
Query: 226 LRLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQ 285
+++ DG L ++ G ++ + + M GH K + + F+P +
Sbjct: 369 YDIAFHQDGS-LAGTGGLDAFG---RVWDLRTGRCIMFLEGHLKEIYGINFSPNGYH--- 421
Query: 286 KNGSSAKPSCPYCCCAVGSKDRSLSVW 312
A GS D + VW
Sbjct: 422 --------------IATGSGDNTCKVW 434
Score = 39.7 bits (91), Expect = 0.015
Identities = 40/167 (23%), Positives = 69/167 (41%), Gaps = 11/167 (6%)
Query: 112 SGKLANVEQWRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLR 171
S KL +++ V+ + H+ V V W P +L + D + +W+ EIL
Sbjct: 304 SVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQ-E 362
Query: 172 GHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWS 231
GHS V + + G + D +V W L T F E G + +++S
Sbjct: 363 GHSMGVYDIAFHQDGSLAGTGGLDAFGRV-----WDLRTGRCIMFLE-GHLKEIYGINFS 416
Query: 232 PDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNP 278
P+G+++ + N T ++ + + H+ VT VKF P
Sbjct: 417 PNGYHIATGSGDN----TCKVWDLRQRRCVYTIPAHQNLVTGVKFEP 459
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.130 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,881,752
Number of Sequences: 37866
Number of extensions: 1825452
Number of successful extensions: 9273
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 136
Number of HSP's successfully gapped in prelim test: 249
Number of HSP's that attempted gapping in prelim test: 7033
Number of HSP's gapped (non-prelim): 1677
length of query: 1017
length of database: 18,247,518
effective HSP length: 112
effective length of query: 905
effective length of database: 14,006,526
effective search space: 12675906030
effective search space used: 12675906030
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.