Search of human proteins with 21361888

Search of human proteins with 21361888

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21361888 PDZ and LIM domain 2 isoform 2 [Homo sapiens]
         (352 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21361888 PDZ and LIM domain 2 isoform 2 [Homo sapiens]             700   0.0  
gi|28866957 PDZ and LIM domain 2 isoform 1 [Homo sapiens]             650   0.0  
gi|38327612 PDZ and LIM domain 2 isoform 3 [Homo sapiens]             497   e-141
gi|13994151 PDZ and LIM domain 1 [Homo sapiens]                       198   7e-51
gi|19923181 PDZ and LIM domain 4 isoform 1 [Homo sapiens]             170   2e-42
gi|166235176 PDZ and LIM domain protein 3 isoform a [Homo sapiens]    161   9e-40
gi|166235178 PDZ and LIM domain protein 3 isoform b [Homo sapiens]    157   1e-38
gi|196162711 PDZ and LIM domain 4 isoform 2 [Homo sapiens]            114   1e-25
gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]              93   3e-19
gi|122056617 LIM domain binding 3 isoform 3 [Homo sapiens]             90   3e-18
gi|197383077 PDZ and LIM domain 5 isoform a [Homo sapiens]             90   3e-18
gi|197383100 PDZ and LIM domain 5 isoform b [Homo sapiens]             87   2e-17
gi|58533161 PDZ and LIM domain 5 isoform e [Homo sapiens]              86   5e-17
gi|58533159 PDZ and LIM domain 5 isoform d [Homo sapiens]              86   5e-17
gi|11496885 PDZ and LIM domain 7 isoform 1 [Homo sapiens]              85   9e-17
gi|42741675 PDZ and LIM domain 7 isoform 2 [Homo sapiens]              84   1e-16
gi|122056619 LIM domain binding 3 isoform 4 [Homo sapiens]             81   1e-15
gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens]             81   1e-15
gi|47157328 PDZ and LIM domain 7 isoform 4 [Homo sapiens]              79   8e-15
gi|166706868 synaptopodin 2-like isoform a [Homo sapiens]              69   8e-12
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom...    62   1e-09
gi|153070254 MAGI family member, X-linked isoform b [Homo sapiens]     60   3e-09
gi|153070258 MAGI family member, X-linked isoform a [Homo sapiens]     58   1e-08
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom...    57   2e-08
gi|203098098 shroom family member 3 protein [Homo sapiens]             55   1e-07
gi|193083191 synaptopodin 2 isoform c [Homo sapiens]                   54   2e-07
gi|193083185 synaptopodin 2 isoform b [Homo sapiens]                   54   2e-07
gi|193083183 synaptopodin 2 isoform a [Homo sapiens]                   54   2e-07
gi|4502175 apical protein of Xenopus-like [Homo sapiens]               52   8e-07
gi|112363080 microtubule associated serine/threonine kinase 2 [H...    51   1e-06

>gi|21361888 PDZ and LIM domain 2 isoform 2 [Homo sapiens]
          Length = 352

 Score =  700 bits (1807), Expect = 0.0
 Identities = 352/352 (100%), Positives = 352/352 (100%)

Query: 1   MALTVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGM 60
           MALTVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGM
Sbjct: 1   MALTVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGM 60

Query: 61  LHAEAQSKIRQSPSPLRLQLDRSQATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRS 120
           LHAEAQSKIRQSPSPLRLQLDRSQATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRS
Sbjct: 61  LHAEAQSKIRQSPSPLRLQLDRSQATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRS 120

Query: 121 SYSSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQSLACSPGLPAADRLSYSGRPGSRQ 180
           SYSSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQSLACSPGLPAADRLSYSGRPGSRQ
Sbjct: 121 SYSSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQSLACSPGLPAADRLSYSGRPGSRQ 180

Query: 181 AGLGRAGDSAVLVLPPSPGPRSSRPSMDSEGGSLLLDEDSEVFKMLQENREGRAAPRQSS 240
           AGLGRAGDSAVLVLPPSPGPRSSRPSMDSEGGSLLLDEDSEVFKMLQENREGRAAPRQSS
Sbjct: 181 AGLGRAGDSAVLVLPPSPGPRSSRPSMDSEGGSLLLDEDSEVFKMLQENREGRAAPRQSS 240

Query: 241 SFRLLQEALEAEERGGTPAFLPSSLSPQSSLPASRALATPPKLHTCEKCSTSIANQAVRI 300
           SFRLLQEALEAEERGGTPAFLPSSLSPQSSLPASRALATPPKLHTCEKCSTSIANQAVRI
Sbjct: 241 SFRLLQEALEAEERGGTPAFLPSSLSPQSSLPASRALATPPKLHTCEKCSTSIANQAVRI 300

Query: 301 QEGRYRHPGCYTCADCGLNLKMRGHFWVGDELYCEKHARQRYSAPATLSSRA 352
           QEGRYRHPGCYTCADCGLNLKMRGHFWVGDELYCEKHARQRYSAPATLSSRA
Sbjct: 301 QEGRYRHPGCYTCADCGLNLKMRGHFWVGDELYCEKHARQRYSAPATLSSRA 352


>gi|28866957 PDZ and LIM domain 2 isoform 1 [Homo sapiens]
          Length = 366

 Score =  650 bits (1677), Expect = 0.0
 Identities = 327/327 (100%), Positives = 327/327 (100%)

Query: 1   MALTVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGM 60
           MALTVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGM
Sbjct: 1   MALTVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGM 60

Query: 61  LHAEAQSKIRQSPSPLRLQLDRSQATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRS 120
           LHAEAQSKIRQSPSPLRLQLDRSQATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRS
Sbjct: 61  LHAEAQSKIRQSPSPLRLQLDRSQATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRS 120

Query: 121 SYSSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQSLACSPGLPAADRLSYSGRPGSRQ 180
           SYSSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQSLACSPGLPAADRLSYSGRPGSRQ
Sbjct: 121 SYSSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQSLACSPGLPAADRLSYSGRPGSRQ 180

Query: 181 AGLGRAGDSAVLVLPPSPGPRSSRPSMDSEGGSLLLDEDSEVFKMLQENREGRAAPRQSS 240
           AGLGRAGDSAVLVLPPSPGPRSSRPSMDSEGGSLLLDEDSEVFKMLQENREGRAAPRQSS
Sbjct: 181 AGLGRAGDSAVLVLPPSPGPRSSRPSMDSEGGSLLLDEDSEVFKMLQENREGRAAPRQSS 240

Query: 241 SFRLLQEALEAEERGGTPAFLPSSLSPQSSLPASRALATPPKLHTCEKCSTSIANQAVRI 300
           SFRLLQEALEAEERGGTPAFLPSSLSPQSSLPASRALATPPKLHTCEKCSTSIANQAVRI
Sbjct: 241 SFRLLQEALEAEERGGTPAFLPSSLSPQSSLPASRALATPPKLHTCEKCSTSIANQAVRI 300

Query: 301 QEGRYRHPGCYTCADCGLNLKMRGHFW 327
           QEGRYRHPGCYTCADCGLNLKMRGHFW
Sbjct: 301 QEGRYRHPGCYTCADCGLNLKMRGHFW 327


>gi|38327612 PDZ and LIM domain 2 isoform 3 [Homo sapiens]
          Length = 278

 Score =  497 bits (1279), Expect = e-141
 Identities = 255/255 (100%), Positives = 255/255 (100%)

Query: 1   MALTVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGM 60
           MALTVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGM
Sbjct: 1   MALTVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGM 60

Query: 61  LHAEAQSKIRQSPSPLRLQLDRSQATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRS 120
           LHAEAQSKIRQSPSPLRLQLDRSQATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRS
Sbjct: 61  LHAEAQSKIRQSPSPLRLQLDRSQATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRS 120

Query: 121 SYSSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQSLACSPGLPAADRLSYSGRPGSRQ 180
           SYSSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQSLACSPGLPAADRLSYSGRPGSRQ
Sbjct: 121 SYSSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQSLACSPGLPAADRLSYSGRPGSRQ 180

Query: 181 AGLGRAGDSAVLVLPPSPGPRSSRPSMDSEGGSLLLDEDSEVFKMLQENREGRAAPRQSS 240
           AGLGRAGDSAVLVLPPSPGPRSSRPSMDSEGGSLLLDEDSEVFKMLQENREGRAAPRQSS
Sbjct: 181 AGLGRAGDSAVLVLPPSPGPRSSRPSMDSEGGSLLLDEDSEVFKMLQENREGRAAPRQSS 240

Query: 241 SFRLLQEALEAEERG 255
           SFRLLQEALEAEERG
Sbjct: 241 SFRLLQEALEAEERG 255


>gi|13994151 PDZ and LIM domain 1 [Homo sapiens]
          Length = 329

 Score =  198 bits (503), Expect = 7e-51
 Identities = 127/348 (36%), Positives = 189/348 (54%), Gaps = 42/348 (12%)

Query: 5   VDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGMLHAE 64
           +D+ GP PWGFR+ GG+DF  P+ +++V    KA  A+L  GD+I AI+GE+   M H E
Sbjct: 6   IDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSNMTHLE 65

Query: 65  AQSKIRQSPSPLRLQLDRSQ--ATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRSSY 122
           AQ++I+     L L + RS+    SP  T             +G    Y  + +S     
Sbjct: 66  AQNRIKGCTDNLTLTVARSEHKVWSPLVTE------------EGKRHPYKMNLASEPQEV 113

Query: 123 SSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQSLACSPGLPAADRLS-YSGRPGSRQA 181
               S   R+  PF+  P+SS  T    I+  + + A   GL +++ +S ++    S+ A
Sbjct: 114 LHIGSAHNRSAMPFTASPASS--TTARVITNQYNNPA---GLYSSENISNFNNALESKTA 168

Query: 182 GLGRAGDSAVL--VLPPSPGPRSSRPSMDSEGGSLLLDEDSEVFKMLQENREGRAAPRQS 239
             G   +S  L    PPS               SL++D++SEV+KMLQE +E    P+QS
Sbjct: 169 ASGVEANSRPLDHAQPPS---------------SLVIDKESEVYKMLQEKQELNEPPKQS 213

Query: 240 SSFRLLQEALEAEERG--GTPAFLPSSLSPQSSLPASRALATPPKLHTCEKCSTSIANQA 297
           +SF +LQE LE+EE+G    P+   S  +P + + AS  +    KL  C+KC T I    
Sbjct: 214 TSFLVLQEILESEEKGDPNKPSGFRSVKAPVTKVAAS--IGNAQKLPMCDKCGTGIVGVF 271

Query: 298 VRIQEGRYRHPGCYTCADCGLNLKMRGHFWVGDELYCEKHARQRYSAP 345
           V++++ R+RHP CY C DCG NLK +GHF+V D++YCEKHAR+R + P
Sbjct: 272 VKLRD-RHRHPECYVCTDCGTNLKQKGHFFVEDQIYCEKHARERVTPP 318


>gi|19923181 PDZ and LIM domain 4 isoform 1 [Homo sapiens]
          Length = 330

 Score =  170 bits (430), Expect = 2e-42
 Identities = 119/354 (33%), Positives = 163/354 (46%), Gaps = 50/354 (14%)

Query: 1   MALTVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGM 60
           M  +V + GP+PWGFR+ GGRDF  P+ +++V    KA  A L PGD+I AINGES E M
Sbjct: 1   MPHSVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELM 60

Query: 61  LHAEAQSKIRQSPSPLRLQLDRSQATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRS 120
            H EAQ++I+     L L + R +  S      DS  +         ++  + + S   S
Sbjct: 61  THLEAQNRIKGCHDHLTLSVSRPEGRSWPSAPDDSKAQAHRIHIDPEIQDGSPTTSRRPS 120

Query: 121 SYSS-PTSLSPRAGSPFSPPPS---SSSLTGEAAISRSFQSLACSPGLPAADRLSYSGRP 176
              + P    P  GSP+  PP      + + EA +     +L  SP              
Sbjct: 121 GTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSP-------------- 166

Query: 177 GSRQAGLGRAGDSAVLVLPPSPGPRSSRPSMDSEGGSLLLDEDSEVFKMLQENREGRAA- 235
                             PPS  P    P          +D  SEV++ML+E  E  AA 
Sbjct: 167 ------------------PPSADPARGLP----RSRDCRVDLGSEVYRMLREPAEPVAAE 204

Query: 236 PRQSSSFRLLQEALEAEERGGTPAFLPSSLSPQSSLPASRALATPPK----LHTCEKCST 291
           P+QS SFR LQ  LEA E G  P   P    P++  P +  L  P      L  C +C  
Sbjct: 205 PKQSGSFRYLQGMLEAGEGGDWPG--PGG--PRNLKPTASKLGAPLSGLQGLPECTRCGH 260

Query: 292 SIANQAVRIQEGRYRHPGCYTCADCGLNLKMRGHFWVGDELYCEKHARQRYSAP 345
            I    V+ ++  Y HP C+ C+DCGLNLK RG+F++ + LYCE HA+ R   P
Sbjct: 261 GIVGTIVKARDKLY-HPECFMCSDCGLNLKQRGYFFLDERLYCESHAKARVKPP 313


>gi|166235176 PDZ and LIM domain protein 3 isoform a [Homo sapiens]
          Length = 364

 Score =  161 bits (407), Expect = 9e-40
 Identities = 116/370 (31%), Positives = 184/370 (49%), Gaps = 43/370 (11%)

Query: 1   MALTVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGM 60
           M  TV + GPAPWGFR++GG DF+ P+++T++    KA  A+L PGD+I+AI+G   E M
Sbjct: 1   MPQTVILPGPAPWGFRLSGGIDFNQPLVITRITPGSKAAAANLCPGDVILAIDGFGTESM 60

Query: 61  LHAEAQSKIRQSPSPLRLQLDRSQAT--SPGQTNGDSSLEVLATRFQGSVR--TYTESQS 116
            HA+AQ +I+ +   L L++DR +    SP Q + D          +   +   Y E + 
Sbjct: 61  THADAQDRIKAAAHQLCLKIDRGETHLWSP-QVSEDGKAHPFKINLESEPQDGNYFEHKH 119

Query: 117 SLR----------SSYSSPTSLSPRAGSPFSPPPSSSSLT----GEAAISRSFQSLACSP 162
           ++R          S  S+P+ +    GS  S P S S+++    G+  ++        +P
Sbjct: 120 NIRPKPFVIPGRSSGCSTPSGID--CGSGRSTPSSVSTVSTICPGDLKVAAKL-----AP 172

Query: 163 GLPAADRLSYSGRPGSRQAGLG-------RAGDSAVLVLPPSPGPRSSRPSMDSEGGSLL 215
            +P    L     PG +             + D+ +  L            + SE  + +
Sbjct: 173 NIPLEMEL-----PGVKIVHAQFNTPMQLYSDDNIMETLQGQVSTALGETPLMSEPTASV 227

Query: 216 LDEDSEVFKMLQENREGRAAPRQSSSFRLLQEALEAEERGGTPAFLPSSLSPQSSLPASR 275
             E S+V++ML +NR     PRQS SFR+LQ  ++ +     PA   S  +P + +    
Sbjct: 228 PPE-SDVYRMLHDNRNEPTQPRQSGSFRVLQGMVD-DGSDDRPAGTRSVRAPVTKVHGGS 285

Query: 276 ALATPPKLHTCEKCSTSIANQAVRIQEGRYRHPGCYTCADCGLNLKMRGHFWVGDELYCE 335
             A   ++  C+KC + I    V+ ++ +YRHP C+ CADC LNLK +G+F++  ELYCE
Sbjct: 286 GGAQ--RMPLCDKCGSGIVGAVVKARD-KYRHPECFVCADCNLNLKQKGYFFIEGELYCE 342

Query: 336 KHARQRYSAP 345
            HAR R   P
Sbjct: 343 THARARTKPP 352


>gi|166235178 PDZ and LIM domain protein 3 isoform b [Homo sapiens]
          Length = 316

 Score =  157 bits (398), Expect = 1e-38
 Identities = 109/347 (31%), Positives = 167/347 (48%), Gaps = 45/347 (12%)

Query: 1   MALTVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGM 60
           M  TV + GPAPWGFR++GG DF+ P+++T++    KA  A+L PGD+I+AI+G   E M
Sbjct: 1   MPQTVILPGPAPWGFRLSGGIDFNQPLVITRITPGSKAAAANLCPGDVILAIDGFGTESM 60

Query: 61  LHAEAQSKIRQSPSPLRLQLDRSQATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRS 120
            HA+AQ +I+ +   L L++DR          G++ L        G    +  +  S   
Sbjct: 61  THADAQDRIKAAAHQLCLKIDR----------GETHLWSPQVSEDGKAHPFKINLESEPQ 110

Query: 121 SYSSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQSLACSPGLPAADRLSYSGRPGSRQ 180
            +    +   R   PF            A I    Q ++ S   P    +        + 
Sbjct: 111 EFKPIGTAHNRRAQPF---------VAAANIDDKRQVVSASYNSP----IGLYSTSNIQD 157

Query: 181 AGLGRAGDSAVLVLPPSPG--PRSSRPSMDSEGGSLLLDEDSEVFKMLQENREGRAAPRQ 238
           A  G+       ++P SP   P +S P             +S+V++ML +NR     PRQ
Sbjct: 158 ALHGQLRG----LIPSSPQNEPTASVPP------------ESDVYRMLHDNRNEPTQPRQ 201

Query: 239 SSSFRLLQEALEAEERGGTPAFLPSSLSPQSSLPASRALATPPKLHTCEKCSTSIANQAV 298
           S SFR+LQ  ++ +     PA   S  +P + +      A   ++  C+KC + I    V
Sbjct: 202 SGSFRVLQGMVD-DGSDDRPAGTRSVRAPVTKVHGGSGGAQ--RMPLCDKCGSGIVGAVV 258

Query: 299 RIQEGRYRHPGCYTCADCGLNLKMRGHFWVGDELYCEKHARQRYSAP 345
           + ++ +YRHP C+ CADC LNLK +G+F++  ELYCE HAR R   P
Sbjct: 259 KARD-KYRHPECFVCADCNLNLKQKGYFFIEGELYCETHARARTKPP 304


>gi|196162711 PDZ and LIM domain 4 isoform 2 [Homo sapiens]
          Length = 246

 Score =  114 bits (286), Expect = 1e-25
 Identities = 91/284 (32%), Positives = 126/284 (44%), Gaps = 45/284 (15%)

Query: 1   MALTVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGM 60
           M  +V + GP+PWGFR+ GGRDF  P+ +++V    KA  A L PGD+I AINGES E M
Sbjct: 1   MPHSVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELM 60

Query: 61  LHAEAQSKIRQSPSPLRLQLDRSQATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRS 120
            H EAQ++I+     L L + R +  S      DS  +         ++  + + S   S
Sbjct: 61  THLEAQNRIKGCHDHLTLSVSRPEGRSWPSAPDDSKAQAHRIHIDPEIQDGSPTTSRRPS 120

Query: 121 SYSS-PTSLSPRAGSPFSPPPS---SSSLTGEAAISRSFQSLACSPGLPAADRLSYSGRP 176
              + P    P  GSP+  PP      + + EA +     +L  SP              
Sbjct: 121 GTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSP-------------- 166

Query: 177 GSRQAGLGRAGDSAVLVLPPSPGPRSSRPSMDSEGGSLLLDEDSEVFKMLQENREGRAA- 235
                             PPS  P    P          +D  SEV++ML+E  E  AA 
Sbjct: 167 ------------------PPSADPARGLP----RSRDCRVDLGSEVYRMLREPAEPVAAE 204

Query: 236 PRQSSSFRLLQEALEAEERGGTPAFLPSSLSPQSSLPASRALAT 279
           P+QS SFR LQ  LEA E GG P+   S     S++P++    T
Sbjct: 205 PKQSGSFRYLQGMLEAGE-GGAPS---SRHGTSSTIPSASCAVT 244


>gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]
          Length = 727

 Score = 93.2 bits (230), Expect = 3e-19
 Identities = 94/348 (27%), Positives = 143/348 (41%), Gaps = 59/348 (16%)

Query: 1   MALTVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGM 60
           M+ +V + GP PWGFR+ GG+DF+ P+ ++++    KA  + L  GD++VAI+G + + M
Sbjct: 1   MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTM 60

Query: 61  LHAEAQSKIRQSPSPLRLQLDRSQATSPGQTNG---DSSLEVLATRFQGSVRTYTESQSS 117
            H EAQ+KI+ +   L L L +S+   P  T      + L V+  +   ++ T       
Sbjct: 61  THLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKDPALDT------- 113

Query: 118 LRSSYSSPTSLSPRAGSPFSPPPSSSSLTGEAAISR--SFQSLA--CSPGLPAA------ 167
              S  +P+       SP +P       T   A SR  +F SLA    PG P A      
Sbjct: 114 -NGSLVAPSPSPEARASPGTPGTPELRPTFSPAFSRPSAFSSLAEASDPGPPRASLRAKT 172

Query: 168 ------DRLSYSGRPGSRQA-------GLGRAGDSAVLVLPPSPGPRSSRPSMDSEGGSL 214
                 D L     PGS Q        GL  A     +        R     +   GGSL
Sbjct: 173 SPEGARDLLGPKALPGSSQPRQYNNPIGLYSAETLREMAQMYQMSLRGKASGVGLPGGSL 232

Query: 215 -----LLDEDSEVFKMLQENREG----------RAAPRQSSSFRLLQEAL---------- 249
                 +D  S V++ + +++            R++  QS SFR+L +            
Sbjct: 233 PIKDLAVDSASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDE 292

Query: 250 EAEERGGTPAFLPSSLSPQSSLPASRALATPPKLHTCEKCSTSIANQA 297
           EA  R  TP       + Q++ P   A A PP   +    S  +A  A
Sbjct: 293 EALRRSSTPIEHAPVCTSQATTPLLPASAQPPAAASPSAASPPLATAA 340



 Score = 36.6 bits (83), Expect = 0.035
 Identities = 70/305 (22%), Positives = 114/305 (37%), Gaps = 34/305 (11%)

Query: 60  MLHAEAQSKIRQSPSPLRLQLDRSQATSPGQTN-GDSSLEVLATRFQGSVRTYTESQSSL 118
           +L A AQ     SPS     L    AT+   T    +S    A+    S R    S S  
Sbjct: 316 LLPASAQPPAAASPSAASPPL----ATAAAHTAIASASTTAPASSPADSPRPQASSYSPA 371

Query: 119 RSSYSSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQSLACSPGLPAADRLSYSGRPGS 178
            ++ S+P + +  +  P +P P    +T  +     +Q +  S   P+    +YS  P +
Sbjct: 372 VAASSAPATHTSYSEGPAAPAPKPRVVTTASIRPSVYQPVPASTYSPSPGA-NYSPTPYT 430

Query: 179 RQAGLGRAGDSAVLVLP---------------PSPGPR-SSRPSMDSEGGSLLLDEDSEV 222
                      A    P               PSP P  +  PS+   GG    +  S  
Sbjct: 431 PSPAPAYTPSPAPAYTPSPVPTYTPSPAPAYTPSPAPNYNPAPSVAYSGGPA--EPASRP 488

Query: 223 FKMLQENREGRAAPRQSSSFRLLQEALEAEERGGTPAFLPSS--LSPQSSLPASRALATP 280
             +  ++   + AP +S++      + +   RGG PA+ P+   + P +     RA   P
Sbjct: 489 PWVTDDSFSQKFAPGKSTT----SISKQTLPRGG-PAYTPAGPQVPPLARGTVQRAERFP 543

Query: 281 PKLHT--CEKCSTSIANQAVRIQEGRYRHPGCYTCADCGLNLKMRGHFWVGDELYCEKHA 338
               T  C  C+  I    + +  GR  HP  +TCA C  +L         + +YCE+  
Sbjct: 544 ASSRTPLCGHCNNVIRGPFL-VAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCY 602

Query: 339 RQRYS 343
            Q ++
Sbjct: 603 EQFFA 607



 Score = 30.0 bits (66), Expect = 3.3
 Identities = 13/36 (36%), Positives = 19/36 (52%)

Query: 303 GRYRHPGCYTCADCGLNLKMRGHFWVGDELYCEKHA 338
           G   H  C+ CA C +NL+ +  +   D   C+KHA
Sbjct: 687 GHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHA 722


>gi|122056617 LIM domain binding 3 isoform 3 [Homo sapiens]
          Length = 330

 Score = 89.7 bits (221), Expect = 3e-18
 Identities = 71/243 (29%), Positives = 113/243 (46%), Gaps = 28/243 (11%)

Query: 1   MALTVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGM 60
           M+ +V + GP PWGFR+ GG+DF+ P+ ++++    KA  + L  GD++VAI+G + + M
Sbjct: 1   MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTM 60

Query: 61  LHAEAQSKIRQSPSPLRLQLDRSQATSPGQTNG---DSSLEVLATRFQGSVRTYTESQSS 117
            H EAQ+KI+ +   L L L +S+   P  T      + L V+  +   ++ T       
Sbjct: 61  THLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKDPALDT------- 113

Query: 118 LRSSYSSPTSLSPRAGSPFSPPPSSSSLTGEAAISR--SFQSL--ACSPGLPAADRLSYS 173
              S  +P+       SP +P       T   A SR  +F SL  A  PG P A   + +
Sbjct: 114 -NGSLVAPSPSPEARASPGTPGTPELRPTFSPAFSRPSAFSSLAEASDPGPPRASLRAKT 172

Query: 174 GRPGSRQAGLGRAGDSAVLVLPPSPGPRSSRPSMDSEGGSLLLDED-SEVFKMLQENREG 232
              G+R             +L P   P SS+P   +    L   E   E+ +M Q +  G
Sbjct: 173 SPEGARD------------LLGPKALPGSSQPRQYNNPIGLYSAETLREMAQMYQMSLRG 220

Query: 233 RAA 235
           +A+
Sbjct: 221 KAS 223


>gi|197383077 PDZ and LIM domain 5 isoform a [Homo sapiens]
          Length = 596

 Score = 89.7 bits (221), Expect = 3e-18
 Identities = 63/193 (32%), Positives = 99/193 (51%), Gaps = 14/193 (7%)

Query: 4   TVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGMLHA 63
           +V + GPAPWGFR+ GG+DF+ P+ ++ + + GKA  A++R GD++++I+G +A+GM H 
Sbjct: 5   SVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMTHL 64

Query: 64  EAQSKIRQSPSPLRLQLDRSQAT---SPGQTNGDSSLEVL----ATRFQGSVRTYTESQS 116
           EAQ+KI+     L + L R+ A     P         EV+     T    S  T T + +
Sbjct: 65  EAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKGEPKEVVKPVPITSPAVSKVTSTNNMA 124

Query: 117 SLRS-----SYSSPTSLS-PRAGSPFSPP-PSSSSLTGEAAISRSFQSLACSPGLPAADR 169
             ++     S SSP   S P   S F+P   ++SS    + ++     L  + GL A   
Sbjct: 125 YNKAPRPFGSVSSPKVTSIPSPSSAFTPAHATTSSHASPSPVAAVTPPLFAASGLHANAN 184

Query: 170 LSYSGRPGSRQAG 182
           LS    P +  AG
Sbjct: 185 LSADQSPSALSAG 197


>gi|197383100 PDZ and LIM domain 5 isoform b [Homo sapiens]
          Length = 487

 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 96/381 (25%), Positives = 152/381 (39%), Gaps = 75/381 (19%)

Query: 4   TVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGMLHA 63
           +V + GPAPWGFR+ GG+DF+ P+ ++ + + GKA  A++R GD++++I+G +A+GM H 
Sbjct: 5   SVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMTHL 64

Query: 64  EAQSKIRQSPSPLRLQLDRSQAT---------SPGQTN--GDSSLEVLATRFQGS----- 107
           EAQ+KI+     L + L R+ A           P  T+   ++S E+   + +GS     
Sbjct: 65  EAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKPTVTSVCSETSQELAEGQRRGSQGDSK 124

Query: 108 ----------VRTYTE-------SQSSLRSSYSSPTSLSPRAGSPFSPPPSSSSLTGEAA 150
                     V  YTE       S +S +          PR G+                
Sbjct: 125 QQNGPPRKHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGT---------------T 169

Query: 151 ISRSFQSLACSPGLPAADRLSYSGRPGSRQAGLGR-------AGDSAVLVLPPS-PGPRS 202
            SRSF+ LA   G    + L  S    +++A   +       +  ++   +P S   P S
Sbjct: 170 QSRSFRILAQITG---TEHLKESEADNTKKANNSQEPSPQLASSVASTRSMPESLDSPTS 226

Query: 203 SRPSMDSEGGSLLLDE--DSEVFKMLQENREGRAAPRQSSSFRLLQEALEAEERGGTPAF 260
            RP + S   +        + V K     R  +  P   S+ R+   A  +       + 
Sbjct: 227 GRPGVTSLTAAAAFKPVGSTGVIKSPSWQRPNQGVP---STGRISNSATYSGSVAPANSA 283

Query: 261 LPSSLSPQSSLPASRALATPPKLHT--CEKCSTSIANQAVR----IQEGRYRHPGCYTCA 314
           L  +          RA   P    T  C  C     NQ +R    +  G+  HP  + CA
Sbjct: 284 LGQTQPSDQDTLVQRAEHIPAGKRTPMCAHC-----NQVIRGPFLVALGKSWHPEEFNCA 338

Query: 315 DCGLNLKMRGHFWVGDELYCE 335
            C   +   G       LYCE
Sbjct: 339 HCKNTMAYIGFVEEKGALYCE 359


>gi|58533161 PDZ and LIM domain 5 isoform e [Homo sapiens]
          Length = 214

 Score = 85.9 bits (211), Expect = 5e-17
 Identities = 36/82 (43%), Positives = 59/82 (71%)

Query: 4  TVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGMLHA 63
          +V + GPAPWGFR+ GG+DF+ P+ ++ + + GKA  A++R GD++++I+G +A+GM H 
Sbjct: 5  SVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMTHL 64

Query: 64 EAQSKIRQSPSPLRLQLDRSQA 85
          EAQ+KI+     L + L R+ A
Sbjct: 65 EAQNKIKGCTGSLNMTLQRASA 86


>gi|58533159 PDZ and LIM domain 5 isoform d [Homo sapiens]
          Length = 234

 Score = 85.9 bits (211), Expect = 5e-17
 Identities = 36/82 (43%), Positives = 59/82 (71%)

Query: 4  TVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGMLHA 63
          +V + GPAPWGFR+ GG+DF+ P+ ++ + + GKA  A++R GD++++I+G +A+GM H 
Sbjct: 5  SVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMTHL 64

Query: 64 EAQSKIRQSPSPLRLQLDRSQA 85
          EAQ+KI+     L + L R+ A
Sbjct: 65 EAQNKIKGCTGSLNMTLQRASA 86


>gi|11496885 PDZ and LIM domain 7 isoform 1 [Homo sapiens]
          Length = 457

 Score = 85.1 bits (209), Expect = 9e-17
 Identities = 98/372 (26%), Positives = 148/372 (39%), Gaps = 72/372 (19%)

Query: 5   VDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGMLHAE 64
           V + GPAPWGFR+ GG+DF+ P+ ++++   GKA  A +  GD +++I+GE+A  + H E
Sbjct: 6   VVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGSLTHIE 65

Query: 65  AQSKIRQSPSPLRLQLDRSQATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRSSYSS 124
           AQ+KIR     L L L R+Q   P Q+         A+        YT + S   +  + 
Sbjct: 66  AQNKIRACGERLSLGLSRAQ---PVQSKPQK-----ASAPAADPPRYTFAPSVSLNKTAR 117

Query: 125 PTSLSPRAGS----------PFSPPPSSSSL------------TGEAAISRSFQSLACSP 162
           P    P A S          P  P  S   L            TG+   SRSF+ LA   
Sbjct: 118 PFGAPPPADSAPQQNGQPLRPLVPDASKQRLMENTEDWRPRPGTGQ---SRSFRILAHLT 174

Query: 163 GL-----PAADRLSYSGRPGSRQAGLGRAGDSAVLVLPPSPGPRSSRPSMDSEGGSLLLD 217
           G      P  + L  S +    +A       +     P  P P  + PS  S     +  
Sbjct: 175 GTEFMQDPDEEHLKKSSQVPRTEA------PAPASSTPQEPWPGPTAPSPTSRPPWAVDP 228

Query: 218 EDSEVFKMLQENREGRAAPRQSSSFRLLQEALEAEERGGTPAFLPSSLSPQSSLPASRAL 277
             +E           R AP ++S+            R   PA  P+ L  ++S+  + A 
Sbjct: 229 AFAE-----------RYAPDKTST---------VLTRHSQPA-TPTPLQSRTSIVQAAAG 267

Query: 278 ATP------PKLHTCEKCSTSIANQAVRIQEGRYRHPGCYTCADCGLNLKMRGHFWVGDE 331
             P       K   C +C   I  + + +  G   HP  + C+ CG  L+  G F     
Sbjct: 268 GVPGGGSNNGKTPVCHQCHKVIRGRYL-VALGHAYHPEEFVCSQCGKVLEEGGFFEEKGA 326

Query: 332 LYCEKHARQRYS 343
           ++C      RY+
Sbjct: 327 IFCPPCYDVRYA 338



 Score = 28.9 bits (63), Expect = 7.3
 Identities = 11/32 (34%), Positives = 17/32 (53%)

Query: 307 HPGCYTCADCGLNLKMRGHFWVGDELYCEKHA 338
           H  C+ CA C +NL+ +  +   D   C+ HA
Sbjct: 422 HDTCFVCAICQINLEGKTFYSKKDRPLCKSHA 453


>gi|42741675 PDZ and LIM domain 7 isoform 2 [Homo sapiens]
          Length = 423

 Score = 84.3 bits (207), Expect = 1e-16
 Identities = 92/350 (26%), Positives = 142/350 (40%), Gaps = 62/350 (17%)

Query: 5   VDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGMLHAE 64
           V + GPAPWGFR+ GG+DF+ P+ ++++   GKA  A +  GD +++I+GE+A  + H E
Sbjct: 6   VVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGSLTHIE 65

Query: 65  AQSKIRQSPSPLRLQLDRSQATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRSSYSS 124
           AQ+KIR     L L L R+Q          S  + + T  +  +R      S  R    +
Sbjct: 66  AQNKIRACGERLSLGLSRAQPV-------QSKPQKVQTPDKQPLRPLVPDASKQR-LMEN 117

Query: 125 PTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQSLACSPGL-----PAADRLSYSGRPGSR 179
                PR G            TG+   SRSF+ LA   G      P  + L  S +    
Sbjct: 118 TEDWRPRPG------------TGQ---SRSFRILAHLTGTEFMQDPDEEHLKKSSQVPRT 162

Query: 180 QAGLGRAGDSAVLVLPPSPGPRSSRPSMDSEGGSLLLDEDSEVFKMLQENREGRAAPRQS 239
           +A       +     P  P P  + PS  S     +    +E           R AP ++
Sbjct: 163 EA------PAPASSTPQEPWPGPTAPSPTSRPPWAVDPAFAE-----------RYAPDKT 205

Query: 240 SSFRLLQEALEAEERGGTPAFLPSSLSPQSSLPASRALATP------PKLHTCEKCSTSI 293
           S+            R   PA  P+ L  ++S+  + A   P       K   C +C   I
Sbjct: 206 ST---------VLTRHSQPA-TPTPLQSRTSIVQAAAGGVPGGGSNNGKTPVCHQCHKVI 255

Query: 294 ANQAVRIQEGRYRHPGCYTCADCGLNLKMRGHFWVGDELYCEKHARQRYS 343
             + + +  G   HP  + C+ CG  L+  G F     ++C      RY+
Sbjct: 256 RGRYL-VALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYA 304


>gi|122056619 LIM domain binding 3 isoform 4 [Homo sapiens]
          Length = 283

 Score = 81.3 bits (199), Expect = 1e-15
 Identities = 36/91 (39%), Positives = 58/91 (63%)

Query: 1  MALTVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGM 60
          M+ +V + GP PWGFR+ GG+DF+ P+ ++++    KA  + L  GD++VAI+G + + M
Sbjct: 1  MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTM 60

Query: 61 LHAEAQSKIRQSPSPLRLQLDRSQATSPGQT 91
           H EAQ+KI+ +   L L L +S+   P  T
Sbjct: 61 THLEAQNKIKSASYNLSLTLQKSKRPIPIST 91


>gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens]
          Length = 617

 Score = 81.3 bits (199), Expect = 1e-15
 Identities = 36/91 (39%), Positives = 58/91 (63%)

Query: 1  MALTVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGM 60
          M+ +V + GP PWGFR+ GG+DF+ P+ ++++    KA  + L  GD++VAI+G + + M
Sbjct: 1  MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTM 60

Query: 61 LHAEAQSKIRQSPSPLRLQLDRSQATSPGQT 91
           H EAQ+KI+ +   L L L +S+   P  T
Sbjct: 61 THLEAQNKIKSASYNLSLTLQKSKRPIPIST 91



 Score = 36.2 bits (82), Expect = 0.045
 Identities = 61/283 (21%), Positives = 105/283 (37%), Gaps = 28/283 (9%)

Query: 67  SKIRQSPSPLRLQLDRSQATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRSSYSSPT 126
           ++  Q P    L+  R QA+S       SS     T +             + ++   P+
Sbjct: 237 TEFMQDPDEEALRRSRPQASSYSPAVAASSAPATHTSYSEGPAAPAPKPRVVTTASIRPS 296

Query: 127 SLSPRAGSPFSPPPSSSSLTGEAAISRSFQSLACSPGLPA-ADRLSYSGRPGSRQAGLGR 185
              P   S +SP P ++               + +P  P+ A   + S  P    + +  
Sbjct: 297 VYQPVPASTYSPSPGAN--------------YSPTPYTPSPAPAYTPSPAPAYTPSPVPT 342

Query: 186 AGDSAVLVLPPSPGPR-SSRPSMDSEGGSLLLDEDSEVFKMLQENREGRAAPRQSSSFRL 244
              S      PSP P  +  PS+   GG    +  S    +  ++   + AP +S++   
Sbjct: 343 YTPSPAPAYTPSPAPNYNPAPSVAYSGGPA--EPASRPPWVTDDSFSQKFAPGKSTT--- 397

Query: 245 LQEALEAEERGGTPAFLPSS--LSPQSSLPASRALATPPKLHT--CEKCSTSIANQAVRI 300
              + +   RGG PA+ P+   + P +     RA   P    T  C  C+  I    + +
Sbjct: 398 -SISKQTLPRGG-PAYTPAGPQVPPLARGTVQRAERFPASSRTPLCGHCNNVIRGPFL-V 454

Query: 301 QEGRYRHPGCYTCADCGLNLKMRGHFWVGDELYCEKHARQRYS 343
             GR  HP  +TCA C  +L         + +YCE+   Q ++
Sbjct: 455 AMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFA 497



 Score = 30.0 bits (66), Expect = 3.3
 Identities = 13/36 (36%), Positives = 19/36 (52%)

Query: 303 GRYRHPGCYTCADCGLNLKMRGHFWVGDELYCEKHA 338
           G   H  C+ CA C +NL+ +  +   D   C+KHA
Sbjct: 577 GHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHA 612


>gi|47157328 PDZ and LIM domain 7 isoform 4 [Homo sapiens]
          Length = 222

 Score = 78.6 bits (192), Expect = 8e-15
 Identities = 36/80 (45%), Positives = 54/80 (67%)

Query: 5  VDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGMLHAE 64
          V + GPAPWGFR+ GG+DF+ P+ ++++   GKA  A +  GD +++I+GE+A  + H E
Sbjct: 6  VVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGSLTHIE 65

Query: 65 AQSKIRQSPSPLRLQLDRSQ 84
          AQ+KIR     L L L R+Q
Sbjct: 66 AQNKIRACGERLSLGLSRAQ 85


>gi|166706868 synaptopodin 2-like isoform a [Homo sapiens]
          Length = 977

 Score = 68.6 bits (166), Expect = 8e-12
 Identities = 38/97 (39%), Positives = 54/97 (55%)

Query: 5   VDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGMLHAE 64
           V ++G APWGFR+ GG +   P+ V+K+  R +A  A LR  D ++AING S   + HA 
Sbjct: 9   VTLSGGAPWGFRLHGGAEQRKPLQVSKIRRRSQAGRAGLRERDQLLAINGVSCTNLSHAS 68

Query: 65  AQSKIRQSPSPLRLQLDRSQATSPGQTNGDSSLEVLA 101
           A S I  S + L L + R     P Q+     L+VL+
Sbjct: 69  AMSLIDASGNQLVLTVQRLADEGPVQSPSPHELQVLS 105



 Score = 30.8 bits (68), Expect = 1.9
 Identities = 38/152 (25%), Positives = 54/152 (35%), Gaps = 13/152 (8%)

Query: 66  QSKIRQSPSPLRLQLDRSQATSPGQTNGDS-------SLEVLATRFQGSV--RTYTESQS 116
           + + + SP+P  L L ++    P     +S       SL   A  F   V  R+Y     
Sbjct: 641 KEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPH 700

Query: 117 SLRSSYSSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQSLACSPGLPAADRLSYSGRP 176
               +       +P   +P +PPP +        +       A S G+P   RL   GR 
Sbjct: 701 VTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRL--QGRG 758

Query: 177 GSRQAGLGRAGDSAVLVLPPSP--GPRSSRPS 206
           G   A      D  V+   P P  GPR   PS
Sbjct: 759 GELFAKRQSRADRYVVEGTPGPGLGPRPRSPS 790


>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
            containing 2 [Homo sapiens]
          Length = 1455

 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 81/322 (25%), Positives = 118/322 (36%), Gaps = 82/322 (25%)

Query: 4    TVDVA-GPAPWGFRITGGRDFHTPIMVTKVAERGKA-KDADLRPGDIIVAINGESAEGML 61
            TVD+  G   +GF I GGR++   + V ++AE G A ++  +R GD I+ INGES   M 
Sbjct: 1147 TVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMT 1206

Query: 62   HAEAQSKIRQSPSPLRLQLDRSQATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRSS 121
            HA A   I+     +RL L R                       G V  Y E      + 
Sbjct: 1207 HARAIELIKSGGRRVRLLLKRG---------------------TGQVPEYDEP-----AP 1240

Query: 122  YSSPTSLSPRAG----------SPFSP----PPSSSS----------LTGEAAISRSFQS 157
            +SSP + +P             +PFSP    PPS  S          +  E  + +  + 
Sbjct: 1241 WSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPSHQISPGPTWDIKREHDVRKPKEL 1300

Query: 158  LACSPGLPAADRLSYSGRPGSRQAGLGRAGDSAVLVLPPSPG-PRSSRPSMDSEGGSLLL 216
             AC        +    G    R A   RA    +   P   G P + RP+ ++    L  
Sbjct: 1301 SAC------GQKKQRLGEQRERSASPQRAARPRLEEAPGGQGRPEAGRPASEARAPGLAA 1354

Query: 217  DEDSEVFKMLQENREGRAAPRQSSSFRLLQE------------------ALEAEERGGTP 258
             + ++  +       G+ APR ++   L +                   ALEAE R G  
Sbjct: 1355 ADAADAAR-----AGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGSGALEAEGRAGAR 1409

Query: 259  AFLPSSLSPQSSLPASRALATP 280
            A       P    PA +A   P
Sbjct: 1410 AGPRPGPRPPGGAPARKAAVAP 1431



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 43/147 (29%), Positives = 66/147 (44%), Gaps = 15/147 (10%)

Query: 13  WGFRITGGRDFHTPIMVTKVAERGKA-KDADLRPGDIIVAINGESAEGMLHAEAQSKIRQ 71
           +GFRI GG +   PI++  V   G A +D  L PGD +V ++G    G  H      +  
Sbjct: 788 FGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHH 847

Query: 72  SPSPLRLQLD-RSQATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRSSYSSPTSLSP 130
           +    ++ L  R +    G+   ++       R  GSV T+    SS RS Y++ T+ + 
Sbjct: 848 AARNGQVNLTVRRKVLCGGEPCPENG------RSPGSVSTH---HSSPRSDYATYTNSNH 898

Query: 131 RAGSPFSPPP----SSSSLTGEAAISR 153
            A S  + PP    S S  T +  I R
Sbjct: 899 AAPSSNASPPEGFASHSLQTSDVVIHR 925



 Score = 32.3 bits (72), Expect = 0.66
 Identities = 31/141 (21%), Positives = 56/141 (39%), Gaps = 12/141 (8%)

Query: 16   RITGGRDFHTPIMVTKVAERGKA-KDADLRPGDIIVAINGESAEGMLHAEAQSKIRQSPS 74
            R   G     P  + ++ +   A + A L+ GD I+A+NG+S   M HA+    I+ +  
Sbjct: 941  RPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGL 1000

Query: 75   PLRLQ-LDRSQATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRSSYSSPTSLSPRAG 133
             + L+ + + +  SP           +A           +S  + +S  + P+  +P + 
Sbjct: 1001 SVTLRIIPQEELNSPTSAPSSEKQSPMA----------QQSPLAQQSPLAQPSPATPNSP 1050

Query: 134  SPFSPPPSSSSLTGEAAISRS 154
                 PP    L G     RS
Sbjct: 1051 IAQPAPPQPLQLQGHENSYRS 1071



 Score = 30.8 bits (68), Expect = 1.9
 Identities = 20/62 (32%), Positives = 28/62 (45%), Gaps = 1/62 (1%)

Query: 13  WGFRITGGRDFHTPIMVTKVAERGKA-KDADLRPGDIIVAINGESAEGMLHAEAQSKIRQ 71
           +GF I GG +    + V  V   G A +D  +  GD+IV IN     G  HA+     + 
Sbjct: 436 FGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQS 495

Query: 72  SP 73
            P
Sbjct: 496 VP 497


>gi|153070254 MAGI family member, X-linked isoform b [Homo sapiens]
          Length = 262

 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 56/183 (30%), Positives = 83/183 (45%), Gaps = 22/183 (12%)

Query: 7   VAGPAPWGFRITGGRDF--HTPIMVTKVAERGKAKDAD-LRPGDIIVAINGESAEGMLHA 63
           V G A +G  + GGRD    TP+ V  + + G A+    L  GD+++ INGES +G+ HA
Sbjct: 62  VRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHA 121

Query: 64  EAQSKIRQSPSPLRLQLDRSQATSPGQTNG--------DSSLEVLATRFQGSVRTYTESQ 115
           +A  +IR     L L + R   T PG+  G        D S +       GS      S 
Sbjct: 122 QAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPDPGGPEVTGS----RSSS 177

Query: 116 SSLRSSYSSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQ----SLACSPG---LPAAD 168
           +SL     S T+L    GSP   P +++     +   R  +     +  SPG   +P+ +
Sbjct: 178 TSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGPWLVPSEE 237

Query: 169 RLS 171
           RLS
Sbjct: 238 RLS 240


>gi|153070258 MAGI family member, X-linked isoform a [Homo sapiens]
          Length = 334

 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 56/188 (29%), Positives = 83/188 (44%), Gaps = 27/188 (14%)

Query: 7   VAGPAPWGFRITGGRDF--HTPIMVTKVAERGKAKDAD-LRPGDIIVAINGESAEGMLHA 63
           V G A +G  + GGRD    TP+ V  + + G A+    L  GD+++ INGES +G+ HA
Sbjct: 129 VRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHA 188

Query: 64  EAQSKIRQSPSPLRLQLDRSQATSPGQTNG-------------DSSLEVLATRFQGSVRT 110
           +A  +IR     L L + R   T PG+  G             D S +       GS   
Sbjct: 189 QAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPDRSPDPGGPEVTGS--- 245

Query: 111 YTESQSSLRSSYSSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQ----SLACSPG--- 163
              S +SL     S T+L    GSP   P +++     +   R  +     +  SPG   
Sbjct: 246 -RSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGPWL 304

Query: 164 LPAADRLS 171
           +P+ +RLS
Sbjct: 305 VPSEERLS 312


>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
            containing 1 isoform c [Homo sapiens]
          Length = 1462

 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 78/278 (28%), Positives = 113/278 (40%), Gaps = 42/278 (15%)

Query: 9    GPAPWGFRITGGRDFHTPIMVTKVAERGKAKDAD-LRPGDIIVAINGESAEGMLHAEAQS 67
            G   +GF + GGR+++  + V ++AE G A+    +R GD I+ INGE+ + M H+ A  
Sbjct: 1129 GAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIE 1188

Query: 68   KIRQSPSPLRLQLDRSQATSPGQTNGDSSLEVLATRFQG--SVRTYTESQS--SLRSSY- 122
             I+     +RL L R   + P + +  S     AT  QG   VR   + +   SL SSY 
Sbjct: 1189 LIKNGGRRVRLFLKRGDGSVP-EYDPSSDRHGPATGPQGVPEVRAGPDRRQHPSLESSYP 1247

Query: 123  -----SSP------TSLSPRAGSPFSPPPSSSSLTGEAAISRSFQSLACSPGLPAADRLS 171
                 SSP       +  P+    +S  P+          SR   S AC P   A +   
Sbjct: 1248 PDLHKSSPHGEKRAHARDPKGSREYSRQPNEHHTWN--GTSRKPDSGACRPKDRAPE--- 1302

Query: 172  YSGRPGSRQAGLGRAGDSAVLVLPPSPGPRSSRPSMDSEGGSLLLDEDSEVFKMLQ---- 227
                 G R A   RA   A    P    P   R    S   +L   E  E  + +     
Sbjct: 1303 -----GRRDAQAERA---AAANGPKRRSPEKRREGTRSADNTLERREKHEKRRDVSPERR 1354

Query: 228  ------ENREGRAAPRQSSSFRLLQEALEAE-ERGGTP 258
                    R+G  + R+ S  RLL++    E  RGG+P
Sbjct: 1355 RERSPTRRRDGSPSRRRRSLERLLEQRRSPERRRGGSP 1392



 Score = 37.0 bits (84), Expect = 0.027
 Identities = 29/125 (23%), Positives = 54/125 (43%), Gaps = 3/125 (2%)

Query: 13  WGFRITGGRDFHTPIMVTKVAERGKA-KDADLRPGDIIVAINGESAEGMLHAEAQSKIRQ 71
           +GFRI GG +   PI +  +   G A  D  LR GD ++ ++G    G  H      ++Q
Sbjct: 823 FGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQ 882

Query: 72  SPSP--LRLQLDRSQATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRSSYSSPTSLS 129
           +     + L + R    +  +T  +      +        + TE + + + S +S  ++S
Sbjct: 883 AAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVS 942

Query: 130 PRAGS 134
             +GS
Sbjct: 943 SGSGS 947



 Score = 30.8 bits (68), Expect = 1.9
 Identities = 19/79 (24%), Positives = 40/79 (50%), Gaps = 6/79 (7%)

Query: 43   LRPGDIIVAINGESAEGMLHAEAQSKIRQSPSPLRLQLDRSQATSPGQTNGDSSLEVLAT 102
            L+ GD I+A+NG S     H++  + I+++ + + L++       PG  + +++L   A 
Sbjct: 1024 LKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI------IPGDESSNATLLTNAE 1077

Query: 103  RFQGSVRTYTESQSSLRSS 121
            +      T+T SQ   + +
Sbjct: 1078 KIATITTTHTPSQQGTQET 1096



 Score = 29.6 bits (65), Expect = 4.3
 Identities = 17/70 (24%), Positives = 31/70 (44%), Gaps = 1/70 (1%)

Query: 13  WGFRITGGRDFHTPIMVTKVAERGKAK-DADLRPGDIIVAINGESAEGMLHAEAQSKIRQ 71
           +GF + GG +    + +  +   G A  D  +  GD+IV++N     G  HA+     + 
Sbjct: 482 FGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQS 541

Query: 72  SPSPLRLQLD 81
            P    + L+
Sbjct: 542 IPIGASVDLE 551


>gi|203098098 shroom family member 3 protein [Homo sapiens]
          Length = 1996

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 34/90 (37%), Positives = 48/90 (53%), Gaps = 3/90 (3%)

Query: 9   GPAPWGFRITGGRDFHTPIMVTKVAERGKAK--DADLRPGDIIVAINGESAEGMLHAEAQ 66
           G APWGF + GG +   P++++KV E GKA    + L+ GD +V IN E        EA 
Sbjct: 34  GGAPWGFTLKGGLEHGEPLIISKVEEGGKADTLSSKLQAGDEVVHIN-EVTLSSSRKEAV 92

Query: 67  SKIRQSPSPLRLQLDRSQATSPGQTNGDSS 96
           S ++ S   LRL + R   T PG  +  +S
Sbjct: 93  SLVKGSYKTLRLVVRRDVCTDPGHADTGAS 122


>gi|193083191 synaptopodin 2 isoform c [Homo sapiens]
          Length = 1109

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 24/80 (30%), Positives = 42/80 (52%)

Query: 3  LTVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGMLH 62
          + + + G APWGFR+ GG++   P+ V K+  + KA  + L  GD +V+ING     + +
Sbjct: 7  ICISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNPCADLTY 66

Query: 63 AEAQSKIRQSPSPLRLQLDR 82
           E    +      L++ + R
Sbjct: 67 PEVIKLMESITDSLQMLIKR 86


>gi|193083185 synaptopodin 2 isoform b [Homo sapiens]
          Length = 1093

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 24/80 (30%), Positives = 42/80 (52%)

Query: 3  LTVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGMLH 62
          + + + G APWGFR+ GG++   P+ V K+  + KA  + L  GD +V+ING     + +
Sbjct: 7  ICISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNPCADLTY 66

Query: 63 AEAQSKIRQSPSPLRLQLDR 82
           E    +      L++ + R
Sbjct: 67 PEVIKLMESITDSLQMLIKR 86


>gi|193083183 synaptopodin 2 isoform a [Homo sapiens]
          Length = 1261

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 24/80 (30%), Positives = 42/80 (52%)

Query: 3  LTVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGMLH 62
          + + + G APWGFR+ GG++   P+ V K+  + KA  + L  GD +V+ING     + +
Sbjct: 7  ICISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNPCADLTY 66

Query: 63 AEAQSKIRQSPSPLRLQLDR 82
           E    +      L++ + R
Sbjct: 67 PEVIKLMESITDSLQMLIKR 86


>gi|4502175 apical protein of Xenopus-like [Homo sapiens]
          Length = 1616

 Score = 52.0 bits (123), Expect = 8e-07
 Identities = 31/79 (39%), Positives = 43/79 (54%), Gaps = 2/79 (2%)

Query: 5   VDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDAD-LRPGDIIVAINGESAEGMLHA 63
           V ++G APWGF + GGR+   P+++TK+ E  KA   D L  GD IV IN     G    
Sbjct: 29  VQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVGINDIGLSG-FRQ 87

Query: 64  EAQSKIRQSPSPLRLQLDR 82
           EA   ++ S   L+L + R
Sbjct: 88  EAICLVKGSHKTLKLVVKR 106



 Score = 32.3 bits (72), Expect = 0.66
 Identities = 59/231 (25%), Positives = 79/231 (34%), Gaps = 24/231 (10%)

Query: 64   EAQSKIRQSPSPLRLQLDRSQATSPGQT--NGDSSLEVLATRF------QGSVRTYTESQ 115
            E QS  RQ+ +  R     SQ   P Q   N  +  E+   R       +G  R  T  +
Sbjct: 958  EGQSTPRQADAQCREGSPGSQQHPPSQKAPNPPTFSELSHCRGAPELPREGRGRAGTLPR 1017

Query: 116  SSLRSSYSSPTSLSPRAGSPFSP---------PPSSSSLTGEAA------ISRSFQSLAC 160
                S  S+P  L PRA SP SP         P SS+ L+   A        R  +    
Sbjct: 1018 DYRYSEESTPADLGPRAQSPGSPLHARGQDSWPVSSALLSKRPAPQRPPPPKREPRRYRA 1077

Query: 161  SPGLPAADRLSYSGRPGSRQAGLGRAGDSAVLVLPPSPGPRSSRPSMDSEGGSLLLDEDS 220
            + G PA   +   GRP    +        A L L  SP   SS    D+   ++      
Sbjct: 1078 TDGAPADAPVGVLGRPFPTPSPASLDVYVARLSLSHSPSVFSSAQPQDTPKATVCERGSQ 1137

Query: 221  EVFKMLQENREGRAAPRQSSSFRLLQEALEAEERGGTPAFLPSSLSPQSSL 271
             V             P +    R LQ A     R  +P F P  L+ +  L
Sbjct: 1138 HVSGDASRPLPEALLPPKQQHLR-LQTATMETSRSPSPQFAPQKLTDKPPL 1187


>gi|112363080 microtubule associated serine/threonine kinase 2 [Homo
            sapiens]
          Length = 1798

 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 74/265 (27%), Positives = 108/265 (40%), Gaps = 29/265 (10%)

Query: 28   MVTKVAERGKAKDADLRPGDIIVAINGESAEGMLHAEAQSKIRQSPSPLRLQLDRSQATS 87
            MV  V + G A +A LR GD+I  +NGE   G++H E    I +S + + +     + TS
Sbjct: 1136 MVWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLENTS 1195

Query: 88   --PGQTNGDSSLEVLATRFQGSVRTYTESQSSLRSSYSSPTSLSPRAGSPFSPPPSSSSL 145
               G     S    +A R + S R     +S  RS      SL  +     S   +S SL
Sbjct: 1196 IKVGPARKGSYKAKMARRSKRS-RGKDGQESRKRS------SLFRKITKQASLLHTSRSL 1248

Query: 146  TGEAAISRSFQSLACSPGLPAADRLSYSGRPGSRQAGLGRAGDSAVLV---LPPSPGPRS 202
               ++++RS  S    PG P     S+S  P S   G     D+   V      S  P S
Sbjct: 1249 ---SSLNRSLSSGESGPGSPTH---SHSLSPRSPTQGYRVTPDAVHSVGGNSSQSSSPSS 1302

Query: 203  SRPSMDSEGGSLLLDEDSEVFKMLQENREGRAAPRQSSSFRLLQEALEAEERGGTPAFLP 262
            S PS  +  G       S +  +  + +    +PR+ S+      ++       TP+  P
Sbjct: 1303 SVPSSPAGSGH---TRPSSLHGLAPKLQRQYRSPRRKSA-----GSIPLSPLAHTPSPPP 1354

Query: 263  SSLSPQ---SSLPASRALATPPKLH 284
             + SPQ   S L    A A P KLH
Sbjct: 1355 PTASPQRSPSPLSGHVAQAFPTKLH 1379


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.128    0.372 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,833,723
Number of Sequences: 37866
Number of extensions: 833124
Number of successful extensions: 5430
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 187
Number of HSP's successfully gapped in prelim test: 518
Number of HSP's that attempted gapping in prelim test: 4443
Number of HSP's gapped (non-prelim): 1428
length of query: 352
length of database: 18,247,518
effective HSP length: 103
effective length of query: 249
effective length of database: 14,347,320
effective search space: 3572482680
effective search space used: 3572482680
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.