Search of human proteins with 11415038

Search of human proteins with 11415038

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
         (556 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|11415038 solute carrier family 22 member 3 [Homo sapiens]         1123   0.0  
gi|4507001 solute carrier family 22 member 2 [Homo sapiens]           572   e-163
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap...   555   e-158
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa...   464   e-130
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa...   277   2e-74
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa...   274   2e-73
gi|4507005 solute carrier family 22 member 5 [Homo sapiens]           273   3e-73
gi|166064021 solute carrier family 22 (organic anion transporter...   273   4e-73
gi|24497499 solute carrier family 22 member 8 [Homo sapiens]          272   5e-73
gi|238814326 solute carrier family 22, member 20 [Homo sapiens]       259   5e-69
gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa...   259   6e-69
gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa...   254   2e-67
gi|24497490 solute carrier family 22 member 4 [Homo sapiens]          250   2e-66
gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]          241   1e-63
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa...   240   2e-63
gi|31542327 solute carrier family 22, member 16 [Homo sapiens]        238   1e-62
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa...   237   2e-62
gi|166197673 solute carrier family 22, member 15 [Homo sapiens]       221   1e-57
gi|148664184 solute carrier family 22, member 10 [Homo sapiens]       216   3e-56
gi|211059435 solute carrier family 22, member 24 [Homo sapiens]       216   6e-56
gi|8923870 solute carrier family 22 member 11 [Homo sapiens]          208   9e-54
gi|157426885 organic cation transporter like 4 [Homo sapiens]         202   9e-52
gi|153791484 putative UST1-like organic anion transporter [Homo ...   171   2e-42
gi|42542386 solute carrier family 22 (organic anion/cation trans...   165   9e-41
gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]          162   7e-40
gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6...   144   3e-34
gi|63999576 solute carrier family 22, member 17 isoform b [Homo ...   143   5e-34
gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1...   138   1e-32
gi|21361834 solute carrier family 22, member 17 isoform a [Homo ...   138   2e-32
gi|170650643 solute carrier family 22, member 23 isoform a [Homo...   132   6e-31

>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
          Length = 556

 Score = 1124 bits (2906), Expect = 0.0
 Identities = 556/556 (100%), Positives = 556/556 (100%)

Query: 1   MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALA 60
           MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALA
Sbjct: 1   MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALA 60

Query: 61  ERCGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNR 120
           ERCGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNR
Sbjct: 61  ERCGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNR 120

Query: 121 SAPLVPCRGGWRYAQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYG 180
           SAPLVPCRGGWRYAQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYG
Sbjct: 121 SAPLVPCRGGWRYAQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYG 180

Query: 181 RIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRR 240
           RIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRR
Sbjct: 181 RIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRR 240

Query: 241 IVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKK 300
           IVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKK
Sbjct: 241 IVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKK 300

Query: 301 GDKALQILRRIAKCNGKYLSSNYSEITVTDEEVSNPSFLDLVRTPQMRKCTLILMFAWFT 360
           GDKALQILRRIAKCNGKYLSSNYSEITVTDEEVSNPSFLDLVRTPQMRKCTLILMFAWFT
Sbjct: 301 GDKALQILRRIAKCNGKYLSSNYSEITVTDEEVSNPSFLDLVRTPQMRKCTLILMFAWFT 360

Query: 361 SAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVA 420
           SAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVA
Sbjct: 361 SAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVA 420

Query: 421 CLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFG 480
           CLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFG
Sbjct: 421 CLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFG 480

Query: 481 GIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKLGSPHS 540
           GIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKLGSPHS
Sbjct: 481 GIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKLGSPHS 540

Query: 541 CKCGRNKKTPVSRSHL 556
           CKCGRNKKTPVSRSHL
Sbjct: 541 CKCGRNKKTPVSRSHL 556


>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
          Length = 555

 Score =  572 bits (1473), Expect = e-163
 Identities = 275/542 (50%), Positives = 382/542 (70%), Gaps = 12/542 (2%)

Query: 5   DEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERCG 64
           D+ L+  GEF  FQ+++F LL L   TFA ++VG+VFLG  PDH  CR P  A L+ RCG
Sbjct: 6   DDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHR-CRSPGVAELSLRCG 64

Query: 65  WSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFP-NRSA- 122
           WSP EE N T P   GP       +C+RY ++         S   C DPLA+   NRS  
Sbjct: 65  WSPAEELNYTVPGP-GPAGEASPRQCRRYEVDWNQ------STFDCVDPLASLDTNRSRL 117

Query: 123 PLVPCRGGWRYAQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRI 182
           PL PCR GW Y    S+IV+EF+LVC N+WMLDL Q+ +N+GF  G+ ++GY ADR+GR 
Sbjct: 118 PLGPCRDGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRK 177

Query: 183 VIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIV 242
           +  L + L     GV++A +P +   +IFR +QG+  K  W+  Y+++TE VG + RR V
Sbjct: 178 LCLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTV 237

Query: 243 GIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGD 302
           GI  Q+ +T+G+++L G+AY +P+W+ +Q  + LP+F FLLYYW +PESPRWLI++ K  
Sbjct: 238 GIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNA 297

Query: 303 KALQILRRIAKCNGKYLSSNYSEITVTDE--EVSNPSFLDLVRTPQMRKCTLILMFAWFT 360
           +A++I++ IAK NGK L ++   + + +E  +  NPSFLDLVRTPQ+RK T+ILM+ WFT
Sbjct: 298 EAMRIIKHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFT 357

Query: 361 SAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVA 420
           S+V+YQGL+M +G+ G N+Y+DFF S +VE P A +I+LTI+R+GRR P+AASN+VAG A
Sbjct: 358 SSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAA 417

Query: 421 CLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFG 480
           CL + F+P  + WL+  ++ LGR+GITMA+EIV LVN+ELYPT +RN GV +CS +CD G
Sbjct: 418 CLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIG 477

Query: 481 GIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKLGSPHS 540
           GII PFL++RL  +WLELPL++FG+L  + GGLV+LLPETKG ALPET+++ E +  P  
Sbjct: 478 GIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRK 537

Query: 541 CK 542
            K
Sbjct: 538 NK 539


>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
           sapiens]
          Length = 554

 Score =  555 bits (1430), Expect = e-158
 Identities = 272/540 (50%), Positives = 379/540 (70%), Gaps = 12/540 (2%)

Query: 1   MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALA 60
           MP+ D+ L++VGE G FQ++ FL+LCL    FA + VG+VFLG  PDH+ C+ P  A L+
Sbjct: 1   MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHH-CQSPGVAELS 59

Query: 61  ERCGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFP-N 119
           +RCGWSP EE N T P   GP      G+C+RY ++         SALSC DPLA+   N
Sbjct: 60  QRCGWSPAEELNYTVPGL-GPAGEAFLGQCRRYEVDWNQ------SALSCVDPLASLATN 112

Query: 120 RS-APLVPCRGGWRYAQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADR 178
           RS  PL PC+ GW Y    S+IV+EF+LVC ++W LDL Q+ LN GFL G+  +GY ADR
Sbjct: 113 RSHLPLGPCQDGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADR 172

Query: 179 YGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQ 238
           +GR +  L + L   V+GV++AF+PN+   ++FR LQG+  KG WM  Y ++TE VGS  
Sbjct: 173 FGRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGS 232

Query: 239 RRIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITR 298
           RR V I+ QM FT+G++ L G+AY +P+W+ +QLA++LP+FLFLLYYW VPESPRWL+++
Sbjct: 233 RRTVAIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQ 292

Query: 299 KKGDKALQILRRIAKCNGKYLSSNYSEITVTDE--EVSNPSFLDLVRTPQMRKCTLILMF 356
           K+  +A++I+  IA+ NGK   ++   +++ ++  E  +PSF DL RTP++RK T ILM+
Sbjct: 293 KRNTEAIKIMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMY 352

Query: 357 AWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIV 416
            WFT +V+YQGL++ +G   GNLY+DF  S +VE+PGA + L+TI+R+GR  P A SN++
Sbjct: 353 LWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLL 412

Query: 417 AGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGL 476
           AG ACLV  F+   + WL   +  +GR+GIT+A +++ LVN+ELYPT +RN GV +CS L
Sbjct: 413 AGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSL 472

Query: 477 CDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKLG 536
           CD GGII PF++FRL  VW  LPLI+F +L  +  G+ +LLPETKG+ALPET+ D E LG
Sbjct: 473 CDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAENLG 532


>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
           sapiens]
          Length = 506

 Score =  464 bits (1193), Expect = e-130
 Identities = 232/479 (48%), Positives = 330/479 (68%), Gaps = 13/479 (2%)

Query: 1   MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALA 60
           MP+ D+ L++VGE G FQ++ FL+LCL    FA + VG+VFLG  PDH+ C+ P  A L+
Sbjct: 1   MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHH-CQSPGVAELS 59

Query: 61  ERCGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFP-N 119
           +RCGWSP EE N T P   GP      G+C+RY ++         SALSC DPLA+   N
Sbjct: 60  QRCGWSPAEELNYTVPGL-GPAGEAFLGQCRRYEVDWNQ------SALSCVDPLASLATN 112

Query: 120 RS-APLVPCRGGWRYAQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADR 178
           RS  PL PC+ GW Y    S+IV+EF+LVC ++W LDL Q+ LN GFL G+  +GY ADR
Sbjct: 113 RSHLPLGPCQDGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADR 172

Query: 179 YGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQ 238
           +GR +  L + L   V+GV++AF+PN+   ++FR LQG+  KG WM  Y ++TE VGS  
Sbjct: 173 FGRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGS 232

Query: 239 RRIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITR 298
           RR V I+ QM FT+G++ L G+AY +P+W+ +QLA++LP+FLFLLYYW VPESPRWL+++
Sbjct: 233 RRTVAIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQ 292

Query: 299 KKGDKALQILRRIAKCNGKYLSSNYSEITVTDE--EVSNPSFLDLVRTPQMRKCTLILMF 356
           K+  +A++I+  IA+ NGK   ++   +++ ++  E  +PSF DL RTP++RK T ILM+
Sbjct: 293 KRNTEAIKIMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMY 352

Query: 357 AWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIV 416
            WFT +V+YQGL++ +G   GNLY+DF  S +VE+PGA + L+TI+R+GR  P A SN++
Sbjct: 353 LWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLL 412

Query: 417 AGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSG 475
           AG ACLV  F+   + WL   +  +GR+GIT+A +++ LVN+ELYPT +   G + C G
Sbjct: 413 AGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVSGVGPA-CRG 470


>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
           sapiens]
          Length = 563

 Score =  277 bits (709), Expect = 2e-74
 Identities = 186/567 (32%), Positives = 287/567 (50%), Gaps = 36/567 (6%)

Query: 3   SFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAER 62
           +F++ LQ+VG  GRFQ+    L+ L  +  A       F    P H+ CR P+ A L++ 
Sbjct: 2   AFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHH-CRPPADANLSKN 60

Query: 63  CGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSA 122
            G    E W    P  R  +P      C R+         S    L   +   A  N + 
Sbjct: 61  GGL---EVW---LPRDRQGQPES----CLRF--------TSPQWGLPFLNGTEA--NGTG 100

Query: 123 PLVPCRGGWRYAQAH--STIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYG 180
              PC  GW Y  +   STIV+E+DLVC +  +  L Q++  +G L GA   GY ADR G
Sbjct: 101 ATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLG 160

Query: 181 RIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRR 240
           R  + +L+ L   V+G   AFAPNFP++  FR L G+   G  + C  +  E +    R 
Sbjct: 161 RRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRA 220

Query: 241 IVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKK 300
            VG +I   ++LG  +L G+AY +P+W+ +QL ++ P F F +Y W   ES RW  +  +
Sbjct: 221 CVGTLIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGR 280

Query: 301 GDKALQILRRIAKCNGK-----YLSSNYSEITVTDEEV---SNPSFLDLVRTPQMRKCTL 352
            D  L+ L+R+A+ NGK      LS      ++  E        S ++L+R P +R   L
Sbjct: 281 LDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFL 340

Query: 353 ILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAA 412
            L   WF ++  Y GLVM L   G ++Y+   I G V+LP  L+  L I  LGRR    A
Sbjct: 341 CLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMA 400

Query: 413 SNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSL 472
           + ++AG+  L+   +P+  + +RT++A LG+  +  +F  ++L   ELYPT +R  G+ +
Sbjct: 401 ALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGM 460

Query: 473 CSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDV 532
            S +   G I++P L+   A ++  +PL I+G +      + +LLPET G  LP+TV D+
Sbjct: 461 GSTMARVGSIVSP-LVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDL 519

Query: 533 EKLGSPHSCKCG----RNKKTPVSRSH 555
           E   +P   + G    + K+T   + H
Sbjct: 520 ESRWAPTQKEAGIYPRKGKQTRQQQEH 546


>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
           sapiens]
          Length = 550

 Score =  274 bits (700), Expect = 2e-73
 Identities = 181/541 (33%), Positives = 277/541 (51%), Gaps = 32/541 (5%)

Query: 3   SFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAER 62
           +F++ LQ+VG  GRFQ+    L+ L  +  A       F    P H+ CR P+ A L++ 
Sbjct: 2   AFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHH-CRPPADANLSKN 60

Query: 63  CGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSA 122
            G    E W    P  R  +P      C R+         S    L   +   A  N + 
Sbjct: 61  GGL---EVW---LPRDRQGQPES----CLRF--------TSPQWGLPFLNGTEA--NGTG 100

Query: 123 PLVPCRGGWRYAQAH--STIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYG 180
              PC  GW Y  +   STIV+E+DLVC +  +  L Q++  +G L GA   GY ADR G
Sbjct: 101 ATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLG 160

Query: 181 RIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRR 240
           R  + +L+ L   V+G   AFAPNFP++  FR L G+   G  + C  +  E +    R 
Sbjct: 161 RRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRA 220

Query: 241 IVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKK 300
            VG +I   ++LG  +L G+AY +P+W+ +QL ++ P F F +Y W   ES RW  +  +
Sbjct: 221 CVGTLIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGR 280

Query: 301 GDKALQILRRIAKCNGK-----YLSSNYSEITVTDEEV---SNPSFLDLVRTPQMRKCTL 352
            D  L+ L+R+A+ NGK      LS      ++  E        S ++L+R P +R   L
Sbjct: 281 LDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFL 340

Query: 353 ILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAA 412
            L   WF ++  Y GLVM L   G ++Y+   I G V+LP  L+  L I  LGRR    A
Sbjct: 341 CLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMA 400

Query: 413 SNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSL 472
           + ++AG+  L+   +P+  + +RT++A LG+  +  +F  ++L   ELYPT +R  G+ +
Sbjct: 401 ALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGM 460

Query: 473 CSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDV 532
            S +   G I++P L+   A ++  +PL I+G +      + +LLPET G  LP+TV D+
Sbjct: 461 GSTMARVGSIVSP-LVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDL 519

Query: 533 E 533
           E
Sbjct: 520 E 520


>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
          Length = 557

 Score =  273 bits (698), Expect = 3e-73
 Identities = 185/566 (32%), Positives = 303/566 (53%), Gaps = 46/566 (8%)

Query: 1   MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALA 60
           M  +DE    +GE+G FQR +F LL  + +   F  +  VFL   P+H  CR P AA L+
Sbjct: 1   MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHR-CRVPDAANLS 59

Query: 61  ERCGWSPEEEWNRTAPASR--GPEPPERRGRCQRYLLEA-ANDSASATSALSCADPLAAF 117
               W      N T P     G E P     C+RY L   AN SA           L   
Sbjct: 60  S--AWR-----NHTVPLRLRDGREVPHS---CRRYRLATIANFSA-----------LGLE 98

Query: 118 PNRSAPL-----VPCRGGWRYAQAH--STIVSEFDLVCVNAWMLDLTQAILNLGFLTGAF 170
           P R   L       C  GW ++Q    STIV+E++LVC + W   LT ++  +G L G+F
Sbjct: 99  PGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSF 158

Query: 171 TLGYAADRYGRI-VIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVI 229
             G  +DR+GR  V+++   +  G + + + F+ NF +FV+   L G+     ++  +V+
Sbjct: 159 ISGQLSDRFGRKNVLFVTMGMQTGFSFLQI-FSKNFEMFVVLFVLVGMGQISNYVAAFVL 217

Query: 230 VTEIVGSKQRRIVGIV-IQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVV 288
            TEI+G   R I   + + +F+  G ++LP  AYFI +W+ + +A+T+P  L +  +W +
Sbjct: 218 GTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFI 277

Query: 289 PESPRWLITRKKGDKALQILRRIAKCNGKYLSSNY---SEIT-VTDEEVSNPSFLDLVRT 344
           PESPRWLI++ + ++A  I+R+ AK NG  + S     SE+  ++ ++  + + LDL+RT
Sbjct: 278 PESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRT 337

Query: 345 PQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERL 404
             +R  T++ +  W T +V Y GL +    + G+++++ F+S +VE+P  +L  L ++ L
Sbjct: 338 WNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYL 397

Query: 405 GRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTT 464
            RR   A +  + G   L    +P  + +L T +  +G+ G+T AF +VY+  +ELYPT 
Sbjct: 398 PRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTV 457

Query: 465 LRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIA 524
           +RN GV + S     G I++P+ ++ L A    LP I+ G L  +   L + LPE+ G  
Sbjct: 458 VRNMGVGVSSTASRLGSILSPYFVY-LGAYDRFLPYILMGSLTILTAILTLFLPESFGTP 516

Query: 525 LPETVDDVEKLGSPHSCKCGRNKKTP 550
           LP+T+D + ++      K  +++KTP
Sbjct: 517 LPDTIDQMLRV------KGMKHRKTP 536


>gi|166064021 solute carrier family 22 (organic anion transporter),
           member 13 [Homo sapiens]
          Length = 551

 Score =  273 bits (697), Expect = 4e-73
 Identities = 173/551 (31%), Positives = 271/551 (49%), Gaps = 24/551 (4%)

Query: 1   MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALA 60
           M  F + L  +G+FGRFQ ++ +LLC+      F F   VF+     H+      A    
Sbjct: 1   MAQFVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCA---VAWVKN 57

Query: 61  ERCGWSPEEEWNRTAPASRG--PEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFP 118
                S  E+   + P      PEP      C  +    AN  AS    LS         
Sbjct: 58  HTFNLSAAEQLVLSVPLDTAGHPEP------CLMFRPPPAN--ASLQDILS--------- 100

Query: 119 NRSAPLVPCRGGWRYAQAH-STIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAAD 177
           +R     PC  GW Y +    ++ +EF+LVC    + D TQ++   G L G    G   D
Sbjct: 101 HRFNETQPCDMGWEYPENRLPSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCD 160

Query: 178 RYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSK 237
           R GR    L   L   + G+  AF P+F +++  RF       G   +   ++TE VG  
Sbjct: 161 RIGRKATILAQLLLFTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPS 220

Query: 238 QRRIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLIT 297
            R    ++ Q  F+LG ++L G+AY   NW+ +Q+  T P  L   Y+W +PES RWL+T
Sbjct: 221 WRTQAVVLAQCNFSLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLT 280

Query: 298 RKKGDKALQILRRIAKCNGKYLSSNYSEITVTDEEVSNPSFLDLVRTPQMRKCTLILMFA 357
           R + D+A+Q++++ A  N + LS       V ++   + + LDL R PQ+RK TLI+   
Sbjct: 281 RGRMDEAIQLIQKAASVNRRKLSPELMNQLVPEKTGPSGNALDLFRHPQLRKVTLIIFCV 340

Query: 358 WFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVA 417
           WF  ++ Y GL +++G  G ++Y+   I G VE+P     +  ++R GR+     + ++ 
Sbjct: 341 WFVDSLGYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLG 400

Query: 418 GVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLC 477
           G+ C++  F+P  +  + T +A +G++    AF I Y+ ++EL+PT LR  G+ L     
Sbjct: 401 GLMCIIIIFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFS 460

Query: 478 DFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKLGS 537
             GGI+ P L+  L      LP++I+G L  + G L  LLPET G  L +T+ D+E    
Sbjct: 461 RIGGILTP-LVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLELGPH 519

Query: 538 PHSCKCGRNKK 548
           P S K   ++K
Sbjct: 520 PRSPKSVPSEK 530


>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
          Length = 542

 Score =  272 bits (696), Expect = 5e-73
 Identities = 179/540 (33%), Positives = 271/540 (50%), Gaps = 42/540 (7%)

Query: 3   SFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAER 62
           +F E L RVG  G FQ     +L L  +  A   +  +F    P H+ CR P  A+    
Sbjct: 2   TFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHH-CRPPHNAS---- 56

Query: 63  CGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSA 122
                      T P      P  +  RC R++                  P A+ PN + 
Sbjct: 57  -----------TGPWVLPMGPNGKPERCLRFV----------------HPPNASLPNDTQ 89

Query: 123 -PLVPCRGGWRYAQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGR 181
             + PC  GW Y     +IV+E+DLVC +  + ++ Q+I   G L G   LG  +DR+GR
Sbjct: 90  RAMEPCLDGWVYNSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGR 149

Query: 182 IVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRI 241
             I   S L +  +G   AF+P FP++++FRFL G    G  ++  ++  E V ++ R I
Sbjct: 150 RPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAI 209

Query: 242 VGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKG 301
           +   +   +T G  ILPG+AY IP W+ +QL +++P F+F L  W  PES RWL+   K 
Sbjct: 210 MSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKS 269

Query: 302 DKALQILRRIAKCNGK-----YLSSNYSEITVTDE---EVSNPSFLDLVRTPQMRKCTLI 353
            KAL+ILRR+A  NGK      LS    ++ +  E     +  +  DL R P +R+ T  
Sbjct: 270 SKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFC 329

Query: 354 LMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAAS 413
           L  AWF +   Y  L M +   G NLYI   I G V++P   + +L++  LGR    AA+
Sbjct: 330 LSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAA 389

Query: 414 NIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLC 473
            ++AG A L   F+P  +  +RT +A  G+  ++ +F  ++L  SELYPT +R  G+ + 
Sbjct: 390 LLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVS 449

Query: 474 SGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVE 533
           +     G +++P L+     V   +P II+GI A + G   + LPET    LPET++D+E
Sbjct: 450 NLWTRVGSMVSP-LVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLE 508


>gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
          Length = 555

 Score =  259 bits (662), Expect = 5e-69
 Identities = 187/550 (34%), Positives = 266/550 (48%), Gaps = 46/550 (8%)

Query: 3   SFDEALQRVGEFGRFQ-RRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAE 61
           +F + L  +G  GRFQ     LLL   G+     F+        P H  CRGP+    A 
Sbjct: 2   AFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHH--CRGPANHTEAS 59

Query: 62  RCGWSPEEEWNR-TAPASR--GPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFP 118
               +    W R T P  +   PEP  R  + Q  LL                      P
Sbjct: 60  T---NDSGAWLRATIPLDQLGAPEPCRRFTKPQWALLS---------------------P 95

Query: 119 NRSAPLVP---CRGGWRYAQA--HSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLG 173
           N S P      C+ GW Y ++   STIV E+DLVC    + DL Q++   G L GA   G
Sbjct: 96  NSSIPGAATEGCKDGWVYNRSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFG 155

Query: 174 YAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEI 233
             ADR G     + S L +  +G   A+  +F  + +FRFL G+   G  +    +V E 
Sbjct: 156 SLADRLGCKGPLVWSYLQLAASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEW 215

Query: 234 VGSKQRRIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPR 293
           + ++ R + GI++   FTLG +IL G+AY I  W+ +Q AI+ P  +F LY W +PES R
Sbjct: 216 MPTRGRTVAGILLGYSFTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSR 275

Query: 294 WLITRKKGDKALQILRRIAKCNG---------KYLSSNYSEITVTDEEVSNPSFLDLVRT 344
           WL+   K   A+Q L+++A  NG         K + S+Y +        SN S LDL RT
Sbjct: 276 WLLLHGKSQLAVQNLQKVAAMNGRKEEGERLTKEVMSSYIQSEFASVCTSN-SILDLFRT 334

Query: 345 PQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERL 404
           P +RK T  LM  WF+++V Y GL M L   G +LY+   + G++  P  L+   T+  +
Sbjct: 335 PAIRKVTCCLMVIWFSNSVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYV 394

Query: 405 GRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTT 464
           GRR   A+  I+AG+  +   F+PEG   L T  A LG+  +  +F  VYL   ELYPT 
Sbjct: 395 GRRATVASFLILAGLMVIANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTE 454

Query: 465 LRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIA 524
           +R  G+   S     GG+ AP L+  L      LP + FG  A + G  V +L ET+ + 
Sbjct: 455 IRQMGMGFASVHARLGGLTAP-LVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMP 513

Query: 525 LPETVDDVEK 534
           L ET+  +E+
Sbjct: 514 LVETIAAMER 523


>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
           sapiens]
          Length = 546

 Score =  259 bits (661), Expect = 6e-69
 Identities = 176/545 (32%), Positives = 264/545 (48%), Gaps = 22/545 (4%)

Query: 4   FDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERC 63
           F+E L++VG FG FQ R   LL L  V     F+  +FL   P H  C  P A A     
Sbjct: 3   FEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHR-CALPGAPA----- 56

Query: 64  GWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSAP 123
            +S ++ W     A    EP      C R+    A  + +          L   P     
Sbjct: 57  NFSHQDVW---LEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEP----A 109

Query: 124 LVPCRGGWRY--AQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGR 181
            VPC  GW Y  ++  STI +E+DLVC    +          G L GA   GY +DR+GR
Sbjct: 110 TVPCSQGWEYDHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGR 169

Query: 182 IVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRI 241
             + L++ +   V G+  A + ++ +F I R L G    G  +    +  E +  + R +
Sbjct: 170 RRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTV 229

Query: 242 VGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKG 301
            G++   F+T G+++L  + Y I +W+ + LA+TLP    +L  W VPES RWL+T+   
Sbjct: 230 AGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHV 289

Query: 302 DKALQILRRIAKCNGK------YLSSNYSEITVTDEEVSNPSFLDLVRTPQMRKCTLILM 355
            +A + L   A+ NG+      +     S++   +  V  PS+LDL RTP++R  +L  +
Sbjct: 290 KEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCV 349

Query: 356 FAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNI 415
             WF     Y GL + +  +G N+Y    + G VELP  LL+ L++   GRRL  A + +
Sbjct: 350 VVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLL 409

Query: 416 VAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSG 475
              +A      +   +    T +A +G+     AF   YL  SELYPT LR  G+ L + 
Sbjct: 410 GTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTAL 469

Query: 476 LCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKL 535
           +   GG +AP L   L  VWL LP + +G +A +  G  +LLPET+   LPET+ DVE+ 
Sbjct: 470 VGRLGGSLAP-LAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERK 528

Query: 536 GSPHS 540
            +P S
Sbjct: 529 SAPTS 533


>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
           sapiens]
          Length = 548

 Score =  254 bits (648), Expect = 2e-67
 Identities = 176/547 (32%), Positives = 264/547 (48%), Gaps = 24/547 (4%)

Query: 4   FDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERC 63
           F+E L++VG FG FQ R   LL L  V     F+  +FL   P H  C  P A A     
Sbjct: 3   FEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHR-CALPGAPA----- 56

Query: 64  GWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSAP 123
            +S ++ W     A    EP      C R+    A  + +          L   P     
Sbjct: 57  NFSHQDVW---LEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEP----A 109

Query: 124 LVPCRGGWRY--AQAHSTIVSE--FDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRY 179
            VPC  GW Y  ++  STI +E  +DLVC    +          G L GA   GY +DR+
Sbjct: 110 TVPCSQGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRF 169

Query: 180 GRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQR 239
           GR  + L++ +   V G+  A + ++ +F I R L G    G  +    +  E +  + R
Sbjct: 170 GRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHR 229

Query: 240 RIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRK 299
            + G++   F+T G+++L  + Y I +W+ + LA+TLP    +L  W VPES RWL+T+ 
Sbjct: 230 TVAGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQG 289

Query: 300 KGDKALQILRRIAKCNGK------YLSSNYSEITVTDEEVSNPSFLDLVRTPQMRKCTLI 353
              +A + L   A+ NG+      +     S++   +  V  PS+LDL RTP++R  +L 
Sbjct: 290 HVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLC 349

Query: 354 LMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAAS 413
            +  WF     Y GL + +  +G N+Y    + G VELP  LL+ L++   GRRL  A +
Sbjct: 350 CVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGT 409

Query: 414 NIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLC 473
            +   +A      +   +    T +A +G+     AF   YL  SELYPT LR  G+ L 
Sbjct: 410 LLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLT 469

Query: 474 SGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVE 533
           + +   GG +AP L   L  VWL LP + +G +A +  G  +LLPET+   LPET+ DVE
Sbjct: 470 ALVGRLGGSLAP-LAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVE 528

Query: 534 KLGSPHS 540
           +  +P S
Sbjct: 529 RKSAPTS 535


>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
          Length = 551

 Score =  250 bits (639), Expect = 2e-66
 Identities = 171/551 (31%), Positives = 280/551 (50%), Gaps = 42/551 (7%)

Query: 1   MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALA 60
           M  +DE +  +GE+G FQR +F LL  + +   F  + VVFL   P+H  CR P AA L+
Sbjct: 1   MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHR-CRVPDAANLS 59

Query: 61  ERCGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEA-ANDSASATSALSCADPLAAFPN 119
                     W   +   R  +  E    C RY L   AN SA           L   P 
Sbjct: 60  SA--------WRNNSVPLRLRDGREVPHSCSRYRLATIANFSA-----------LGLEPG 100

Query: 120 RSAPL-----VPCRGGWRYAQAH--STIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTL 172
           R   L       C  GW ++Q    ST+V+E++LVC + W + LT ++  +G L G+F  
Sbjct: 101 RDVDLGQLEQESCLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVS 160

Query: 173 GYAADRYGRI-VIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVT 231
           G  +DR+GR  V++    +  G + + + F+ ++ +F +   + G+     ++  +++ T
Sbjct: 161 GQLSDRFGRKNVLFATMAVQTGFSFLQI-FSISWEMFTVLFVIVGMGQISNYVVAFILGT 219

Query: 232 EIVGSKQRRIVGIV-IQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPE 290
           EI+G   R I   + +  FF +G ++LP  AYFI +W+ + LA+T+P  L +  +W +PE
Sbjct: 220 EILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPE 279

Query: 291 SPRWLITRKKGDKALQILRRIAKCNGKYLSSNYSEITVTDEEVSNPS------FLDLVRT 344
           SPRWLI++++  +A  I+++ AK N   + +    +     E  NP        LDL RT
Sbjct: 280 SPRWLISQRRFREAEDIIQKAAKMNNIAVPA----VIFDSVEELNPLKQQKAFILDLFRT 335

Query: 345 PQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERL 404
             +   T++ +  W  ++V Y  L +    + G+ Y++ F+S ++E+P  +   L +  L
Sbjct: 336 RNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTL 395

Query: 405 GRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTT 464
            RR   AA     G   L    +P    +L   +  LG+ GIT AF ++Y+  +ELYPT 
Sbjct: 396 PRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTL 455

Query: 465 LRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIA 524
           +RN  V + S     G IIAP+ ++ L A    LP I+ G L  + G L +  PE+ G+ 
Sbjct: 456 VRNMAVGVTSTASRVGSIIAPYFVY-LGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMT 514

Query: 525 LPETVDDVEKL 535
           LPET++ ++K+
Sbjct: 515 LPETLEQMQKV 525


>gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]
          Length = 553

 Score =  241 bits (616), Expect = 1e-63
 Identities = 180/562 (32%), Positives = 277/562 (49%), Gaps = 63/562 (11%)

Query: 3   SFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAER 62
           +F E L  VG  GRFQ    +L  +       L V +++L TQ         SAA  + R
Sbjct: 2   AFSELLDLVGGLGRFQ----VLQTMA------LMVSIMWLCTQS---MLENFSAAVPSHR 48

Query: 63  CGWSPEEEWNRTAPASR--------------GPEPPERRGRCQRYLL---EAANDSASAT 105
           C W+P  + N TA AS                P P +R  +C+R+     +  + +A+AT
Sbjct: 49  C-WAPLLD-NSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATAT 106

Query: 106 SALSCADPLAAFPNRSAPLVPCRGGWRYAQA--HSTIVSEFDLVCVNAWMLDLTQAILNL 163
           S               A   PC  GW Y ++   STIV++++LVC +  +  + Q+I   
Sbjct: 107 SW------------SEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLA 154

Query: 164 GFLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTW 223
           G L GA   G A+DR+GR ++   S L + V G   AFAP FPV+ +FRFL      G  
Sbjct: 155 GILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVM 214

Query: 224 MTCYVIVTEIVGSKQRRIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLL 283
           M    ++ E   ++ R +V  +  + F+ G  +   +AY + +W  +QL +++P FL  L
Sbjct: 215 MNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFL 274

Query: 284 YYWVVPESPRWLITRKKGDKALQILRRIAKCNGK-----------YLSSNYSEITVTDEE 332
           Y W + ES RWL+T  + D  LQ L R+A  NGK            LS+   E+++    
Sbjct: 275 YSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPP 334

Query: 333 VSNPSFLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELP 392
            S  +   L+R P +R  T I    WF     + GL + L  +G N+++     GVV++P
Sbjct: 335 ASLGT---LLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIP 391

Query: 393 GALLILLTIERLGRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEI 452
             +  LL +  LGRR   AAS ++AG+  L    +P  +  LR+ +A LG  G+  AF  
Sbjct: 392 AKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTC 451

Query: 453 VYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFL-LFRLAAVWLELPLIIFGILASICG 511
           + + +SEL+PT LR   V L       G I+ P + L  +   W  LPL+++G +  + G
Sbjct: 452 ITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPW--LPLLVYGTVPVLSG 509

Query: 512 GLVMLLPETKGIALPETVDDVE 533
              +LLPET+ + LP+T+ DV+
Sbjct: 510 LAALLLPETQSLPLPDTIQDVQ 531


>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
           sapiens]
          Length = 519

 Score =  240 bits (613), Expect = 2e-63
 Identities = 175/567 (30%), Positives = 265/567 (46%), Gaps = 80/567 (14%)

Query: 3   SFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAER 62
           +F++ LQ+VG  GRFQ+    L+ L  +  A       F    P H+ CR P+ A L++ 
Sbjct: 2   AFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHH-CRPPADANLSKN 60

Query: 63  CGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSA 122
            G    E W    P  R  +P      C R+         S    L   +   A  N + 
Sbjct: 61  GGL---EVW---LPRDRQGQPES----CLRF--------TSPQWGLPFLNGTEA--NGTG 100

Query: 123 PLVPCRGGWRYAQAH--STIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYG 180
              PC  GW Y  +   STIV+E+DLVC +  +  L Q++  +G L GA   GY ADR G
Sbjct: 101 ATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLG 160

Query: 181 RIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRR 240
           R  + +L+ L   V+G   AFAPNFP++  FR L G+   G  + C  +  E +    R 
Sbjct: 161 RRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRA 220

Query: 241 IVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKK 300
            VG +I   ++LG  +L G+AY +P+W+ +QL ++ P F F +Y W   ES RW  +  +
Sbjct: 221 CVGTLIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGR 280

Query: 301 GDKALQILRRIAKCNGK-----YLSSNYSEITVTDEEV---SNPSFLDLVRTPQMRKCTL 352
            D  L+ L+R+A+ NGK      LS      ++  E        S ++L+R P +R   L
Sbjct: 281 LDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFL 340

Query: 353 ILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAA 412
            L   WF ++  Y GLVM L   G ++Y+   I G V+LP  L+  L I  LGRR    A
Sbjct: 341 CLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMA 400

Query: 413 SNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSL 472
           + ++AG+  L+   +P+  + +RT++A LG+  +  +F  ++L   ELYPT +R      
Sbjct: 401 ALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR------ 454

Query: 473 CSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDV 532
                                                   + +LLPET G  LP+TV D+
Sbjct: 455 ---------------------------------------AVTVLLPETLGQPLPDTVQDL 475

Query: 533 EKLGSPHSCKCG----RNKKTPVSRSH 555
           E   +P   + G    + K+T   + H
Sbjct: 476 ESRWAPTQKEAGIYPRKGKQTRQQQEH 502


>gi|31542327 solute carrier family 22, member 16 [Homo sapiens]
          Length = 577

 Score =  238 bits (606), Expect = 1e-62
 Identities = 156/556 (28%), Positives = 264/556 (47%), Gaps = 23/556 (4%)

Query: 4   FDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGP---SAAALA 60
           F+     VG FGRFQR ++ +     ++    ++  VF+G  P H+ CR P   S     
Sbjct: 6   FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTP-HHVCRPPGNVSQVVFH 64

Query: 61  ERCGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNR 120
               WS E+     +   +     + +      L   + +    TS+L            
Sbjct: 65  NHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEY------TG 118

Query: 121 SAPLVPCRGGWRYAQA--HSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADR 178
           S    PC  G+ Y Q    ST V++++LVC   W+  L Q +   G L G+ T GY +DR
Sbjct: 119 SKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDR 178

Query: 179 YGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQ 238
            GR V+   +   + + G+  AFA ++  F+  RF   +   G  +  +V V E +G K 
Sbjct: 179 LGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKS 238

Query: 239 RRIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITR 298
           R    + +  FF +G +++    Y +  W   Q+ ++  +  F+L  WV+PE+P WL++ 
Sbjct: 239 RTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSE 298

Query: 299 KKGDKALQILRRIAKCNGKYLSSNYSEITVTD---------EEVSNPSFLDLVRTPQMRK 349
            + ++A +I+  +AK N +  S   SE+   D          EV   +   L     + K
Sbjct: 299 GRYEEAQKIVDIMAKWN-RASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITK 357

Query: 350 CTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLP 409
            TL +   WFT ++ +    +    +GGN Y++ F+ GVVE+P    + + ++++GRR  
Sbjct: 358 RTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTV 417

Query: 410 FAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFG 469
            A S   + +AC V   +P+    L    A +G+  I  AF ++YL  +ELYPT +R+  
Sbjct: 418 LAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLA 477

Query: 470 VSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETV 529
           V   S +C    I+APF +  L+++W+ +P +  G +A + G L + LPET G  L  T 
Sbjct: 478 VGSGSMVCRLASILAPFSV-DLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTW 536

Query: 530 DDVEKLGSPHSCKCGR 545
           ++  KL S +  K  +
Sbjct: 537 EEAAKLESENESKSSK 552


>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
           sapiens]
          Length = 506

 Score =  237 bits (604), Expect = 2e-62
 Identities = 170/541 (31%), Positives = 255/541 (47%), Gaps = 76/541 (14%)

Query: 3   SFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAER 62
           +F++ LQ+VG  GRFQ+    L+ L  +  A       F    P H+ CR P+ A L++ 
Sbjct: 2   AFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHH-CRPPADANLSKN 60

Query: 63  CGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSA 122
            G    E W    P  R  +P      C R+         S    L   +   A  N + 
Sbjct: 61  GGL---EVW---LPRDRQGQPES----CLRF--------TSPQWGLPFLNGTEA--NGTG 100

Query: 123 PLVPCRGGWRYAQAH--STIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYG 180
              PC  GW Y  +   STIV+E+DLVC +  +  L Q++  +G L GA   GY ADR G
Sbjct: 101 ATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLG 160

Query: 181 RIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRR 240
           R  + +L+ L   V+G   AFAPNFP++  FR L G+   G  + C  +  E +    R 
Sbjct: 161 RRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRA 220

Query: 241 IVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKK 300
            VG +I   ++LG  +L G+AY +P+W+ +QL ++ P F F +Y W   ES RW  +  +
Sbjct: 221 CVGTLIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGR 280

Query: 301 GDKALQILRRIAKCNGK-----YLSSNYSEITVTDEEV---SNPSFLDLVRTPQMRKCTL 352
            D  L+ L+R+A+ NGK      LS      ++  E        S ++L+R P +R   L
Sbjct: 281 LDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFL 340

Query: 353 ILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAA 412
            L   WF ++  Y GLVM L   G ++Y+   I G V+LP  L+  L I  LGRR    A
Sbjct: 341 CLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMA 400

Query: 413 SNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSL 472
           + ++AG+  L+   +P+  + +RT++A LG+  +  +F  ++L   ELYPT +R      
Sbjct: 401 ALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR------ 454

Query: 473 CSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDV 532
                                                   + +LLPET G  LP+TV D+
Sbjct: 455 ---------------------------------------AVTVLLPETLGQPLPDTVQDL 475

Query: 533 E 533
           E
Sbjct: 476 E 476


>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
          Length = 547

 Score =  221 bits (564), Expect = 1e-57
 Identities = 136/410 (33%), Positives = 216/410 (52%), Gaps = 11/410 (2%)

Query: 133 YAQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSCLGV 192
           ++ + ++I SE+ L+   ++ +    +    G   G  + G  +DR+GR  +YL      
Sbjct: 90  FSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALD 149

Query: 193 GVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFTL 252
            +  +   F+P++  F + RFL G+   G  +  +V++ E VG+    + G +  +FF +
Sbjct: 150 ILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAV 209

Query: 253 GIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIA 312
           GI     + YFI +W+ + + + L   +  L    +PESPRWL ++ +  +A + L  IA
Sbjct: 210 GIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIA 269

Query: 313 KCNGKYLSSNYSEITVTDEEV-SNPSFLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMR 371
           K N K L   +S     +       SFLDL R   +   TLILMF WF  ++VY GL + 
Sbjct: 270 KRNRK-LKCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLS 328

Query: 372 LGIIGGNLYIDFFISGVVELPGALLILLTIER--LGRRLPFAASNIVAGVACLVTAFLPE 429
            G +GG++Y +  +SG++E+P   L +  I +   GR+   +A   + G+ACL+  FLPE
Sbjct: 329 AGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPE 388

Query: 430 ----GIAWL--RTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGII 483
               G+  +    +++ LG+L I+ AF IVY+  SELYPT +RN G+  CS     GGII
Sbjct: 389 KKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGII 448

Query: 484 APFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVE 533
           APF+       W  LP I+FG      G L +LLPET    L ET  D++
Sbjct: 449 APFIPSLKYVQW-SLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQ 497


>gi|148664184 solute carrier family 22, member 10 [Homo sapiens]
          Length = 541

 Score =  216 bits (551), Expect = 3e-56
 Identities = 144/419 (34%), Positives = 213/419 (50%), Gaps = 13/419 (3%)

Query: 126 PCRGGWRYAQAH--STIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIV 183
           PC  GW Y Q++  STIV+++DLVC    +  + Q +L  G L G    G+ +DR+GR  
Sbjct: 115 PCVDGWVYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRF 174

Query: 184 IYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVG 243
           I     L + +T    AFAP FPV+ + RFL G           + +TE +    + +V 
Sbjct: 175 ILRWCLLQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVV 234

Query: 244 IVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLF-LLYYWVVPESPRWLITRKKGD 302
           I+     ++G IIL G+AY   +WQ + +  ++P F+F LL  W+V ES RWLI   K D
Sbjct: 235 ILSSGALSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLV-ESARWLIITNKLD 293

Query: 303 KALQILRRIAKCNGKYLSSNYSEITVT--------DEEVSNPSFLDLVRTPQMRKCTLIL 354
           + L+ LR++A+ NG   +     I V         D   +  +  DL R P MRK   IL
Sbjct: 294 EGLKALRKVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICIL 353

Query: 355 MFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASN 414
           +F  F + + + G ++ L  +G N+++   + G V L    L LLT+  +GRR+      
Sbjct: 354 VFLRFANTIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFM 413

Query: 415 IVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCS 474
            + G++ L   F+P+ +  LR  +A LG       F  V +   EL PT LR     +  
Sbjct: 414 FLVGLSILANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDL 473

Query: 475 GLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVE 533
                G  +AP LL  L   +  LP II+GI   I G +V LLPETK + LP+T+ DVE
Sbjct: 474 TASRIGAALAP-LLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVE 531


>gi|211059435 solute carrier family 22, member 24 [Homo sapiens]
          Length = 551

 Score =  216 bits (549), Expect = 6e-56
 Identities = 166/554 (29%), Positives = 258/554 (46%), Gaps = 49/554 (8%)

Query: 4   FDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVV---FLGTQPDHYWCRGP----SA 56
           FD  L +VG  GRFQ  +    C+T +    LF  +V   F    P H  C  P      
Sbjct: 3   FDVLLDQVGGMGRFQICLIAFFCITNI---LLFPNIVLENFTAFTPSHR-CWVPLLDNDT 58

Query: 57  AALAERCGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAA 116
            +  +    S ++    + P      P     +CQR++                      
Sbjct: 59  VSDNDTGTLSKDDLLRISIPLDSNLRPQ----KCQRFI----------HPQWQLLHLNGT 104

Query: 117 FPNRSAP-LVPCRGGWRYAQAH--STIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLG 173
           FPN + P   PC  GW Y ++   STIV+E+DLVC +  +  + Q++   G L G    G
Sbjct: 105 FPNTNEPDTEPCVDGWVYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYG 164

Query: 174 YAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEI 233
           + +DR GR +I  L  L + ++    AFAP F V+ I RFL G          +++  E 
Sbjct: 165 HLSDRVGRKIICKLCFLQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEW 224

Query: 234 VGSKQRRIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPR 293
              + R +  +V+   +++G ++L G+A+ I +W  +QL ++ P  +  L  W + ES R
Sbjct: 225 TLPRSRSMTIMVLLCSYSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESAR 284

Query: 294 WLITRKKGDKALQILRRIAKCNGKYLSSNYSEITVTDEEVSNP------------SFLDL 341
           WLI   + D+ L+ LRR+A  NGK      +E T+T E V +             S   L
Sbjct: 285 WLIINNQLDEGLKELRRVAHINGK----KNTEETLTTELVRSTMKKELDAVRIKTSIFSL 340

Query: 342 VRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTI 401
            R P++R     L F  F   V + GL++ L  +G N+ +   + G V      + LLT+
Sbjct: 341 FRAPKLRMRVFGLCFVRFAITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTL 400

Query: 402 ERLGRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELY 461
             +GRR+         G+  LV  FLP+ +  LR  +ATLG   ++ A     + ++EL 
Sbjct: 401 NHMGRRISQILFTFPVGLFILVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELV 460

Query: 462 PTTLRN--FGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPE 519
           PT LR+   G++  SG    G  +AP LL  L A    LP I +G+   +   +++LLPE
Sbjct: 461 PTILRSTVAGINAVSGRT--GAALAP-LLMTLMAYSPHLPWISYGVFPILAVPVILLLPE 517

Query: 520 TKGIALPETVDDVE 533
           T+ + LP T+ DVE
Sbjct: 518 TRDLPLPNTIQDVE 531


>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
          Length = 550

 Score =  208 bits (530), Expect = 9e-54
 Identities = 139/434 (32%), Positives = 232/434 (53%), Gaps = 14/434 (3%)

Query: 112 DPLAAFPNRS-APLVPCRGGWRYAQA--HSTIVSEFDLVCVNAWMLDLTQAILNLGFLTG 168
           DP A   + S A   PC  GW Y ++   STIV+++DLVC +  +  L+Q+I   G L G
Sbjct: 97  DPNATATSWSEADTEPCVDGWVYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVG 156

Query: 169 AFTLGYAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYV 228
           +F  G  + R+GR  +    CL + V G    FAP F ++   RF+      G +++   
Sbjct: 157 SFIWGLLSYRFGRKPMLSWCCLQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLT 216

Query: 229 IVTEIVGSKQRRIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVV 288
           ++ E   + +R +   V+   F+ G   L G+A+ + +W+ +QLA ++P F   L  W +
Sbjct: 217 LMVEWTTTSRRAVTMTVVGCAFSAGQAALGGLAFALRDWRTLQLAASVPFFAISLISWWL 276

Query: 289 PESPRWLITRKKGDKALQILRRIAKCNGKYLSSNYS-EITVTD--EEVSNP----SFLDL 341
           PES RWLI + K D+ALQ LR++A+ NG   + N + E+ ++   EEV++     S LDL
Sbjct: 277 PESARWLIIKGKPDQALQELRKVARINGHKEAKNLTIEVLMSSVKEEVASAKEPRSVLDL 336

Query: 342 VRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTI 401
              P +R  +  ++   F+  + Y GLV  L  +G ++++   + G V+  G     L +
Sbjct: 337 FCVPVLRWRSCAMLVVNFSLLISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLL 396

Query: 402 ERLGRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELY 461
             LGRR   A S  +AG+A L    +P+ +  LR   A LG+    ++   + +  +EL+
Sbjct: 397 SFLGRRTIQAGSQAMAGLAILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELF 456

Query: 462 PTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVML--LPE 519
           PT +R     +   +   G ++ P +L    A+ L LP +++G++ SI   LV+L  LPE
Sbjct: 457 PTPVRMTADGILHTVGRLGAMMGPLILMSRQALPL-LPPLLYGVI-SIASSLVVLFFLPE 514

Query: 520 TKGIALPETVDDVE 533
           T+G+ LP+T+ D+E
Sbjct: 515 TQGLPLPDTIQDLE 528


>gi|157426885 organic cation transporter like 4 [Homo sapiens]
          Length = 594

 Score =  202 bits (513), Expect = 9e-52
 Identities = 154/544 (28%), Positives = 250/544 (45%), Gaps = 40/544 (7%)

Query: 4   FDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERC 63
           F   L  VGEFG FQ+R+  L  +  +  AF      F+ T    Y C      A+    
Sbjct: 52  FANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPY-CNTSWILAVGPHL 110

Query: 64  GWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSAP 123
             S  E+ N T P +    P      C  YL    N  +     L+  D           
Sbjct: 111 --SKAEQLNLTIPQA----PNGSFLTCFMYLPVPWNLDSIIQFGLNDTDT---------- 154

Query: 124 LVPCRGGWRYAQAHS-TIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRI 182
              C+ GW Y  A   ++++EFDLVC      D  Q +   G   G+       D+ GR 
Sbjct: 155 ---CQDGWIYPDAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRY 211

Query: 183 VIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIV 242
              LLS LG+ + G   AF  +F +++ FRF       G  ++   + TE +  + R   
Sbjct: 212 PAILLSLLGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHA 271

Query: 243 GIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGD 302
            I+   FF +G ++L GIAY +P+WQ + L   +    F+ Y W++PESPRWL+ + K  
Sbjct: 272 IILGHCFFAVGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVK 331

Query: 303 KALQILRRIAKCNGKYLSSN-YSEITVTDEEVSNPSFLDLVRTPQMRKCTLILMFAWFTS 361
           +A Q+L   A  N K + SN   E+ +  ++V+  S LD  +  Q+ K TL++   WFT 
Sbjct: 332 EAKQVLCYAASVNKKTIPSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTV 391

Query: 362 AVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVAC 421
           +  Y  L +R+  +G +++    +  ++E+P  L  +  ++++GR+   A + + A + C
Sbjct: 392 SYTYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWC 451

Query: 422 LVTAFLPEG-----IAWLR----------TTVATLGRLGITMAFEIVYLVNSELYPTTLR 466
           L+  FLPEG     + W R            V  L    +     + +L  +EL PT LR
Sbjct: 452 LLLLFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLR 511

Query: 467 NFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALP 526
             G+ L S     G I++  ++ +  ++   LP+ +  +LA +   L  LLPET+   L 
Sbjct: 512 ATGLGLVSLASVAGAILSLTIISQTPSL---LPIFLCCVLAIVAFSLSSLLPETRDQPLS 568

Query: 527 ETVD 530
           E+++
Sbjct: 569 ESLN 572


>gi|153791484 putative UST1-like organic anion transporter [Homo
           sapiens]
          Length = 547

 Score =  171 bits (432), Expect = 2e-42
 Identities = 119/431 (27%), Positives = 202/431 (46%), Gaps = 12/431 (2%)

Query: 117 FPNRSAP-LVPCRGGWRYAQAH--STIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLG 173
           FPN S P   PC  GW Y Q+   STIV+++DLVC +  +  + + +   G + G    G
Sbjct: 105 FPNTSEPDTEPCVDGWVYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYG 164

Query: 174 YAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEI 233
           + +DR+GR  +   S L + + G   AFAP   V+   RFL G       +   +++ E 
Sbjct: 165 HLSDRFGRKFVLRWSYLQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEW 224

Query: 234 VGSKQRRIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPR 293
           +  +   +   +     ++G I L  +A+ I +   +QL ++ P F+F L+   + ES R
Sbjct: 225 ITHQFCAMALTLTLCAASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESAR 284

Query: 294 WLITRKKGDKALQILRRIAKCNGKYLSSNYSEITVTDEEVSNP--------SFLDLVRTP 345
           WLI   K ++ L+ LR+ A  NG   + +   + V    +           S  +L+R P
Sbjct: 285 WLIINNKPEEGLKELRKAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIP 344

Query: 346 QMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLG 405
            + K    L F  F S + + GL + L  +G N+++   + G V L    +    +  + 
Sbjct: 345 NICKRICFLSFVRFASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMS 404

Query: 406 RRLPFAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTL 465
           RRL       +     L   F+P+ +  LR  +ATLG    ++         +EL P+ +
Sbjct: 405 RRLSQMLLMFLLATCLLAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSII 464

Query: 466 RNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIAL 525
           R     +     + GG +A  ++  L+     LP II+G+ A + G +V+LLPET+   L
Sbjct: 465 RGRATGITGNFANIGGALASLMMI-LSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPL 523

Query: 526 PETVDDVEKLG 536
            +++ DVE  G
Sbjct: 524 LDSIQDVENEG 534


>gi|42542386 solute carrier family 22 (organic anion/cation
           transporter), member 9 [Homo sapiens]
          Length = 553

 Score =  165 bits (418), Expect = 9e-41
 Identities = 118/429 (27%), Positives = 210/429 (48%), Gaps = 17/429 (3%)

Query: 117 FPNRS-APLVPCRGGWRYAQAH--STIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLG 173
           FPN S A + PC  GW Y +    STIV+E+DLVC +  +  + + +   G + G    G
Sbjct: 105 FPNTSDADMEPCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGG 164

Query: 174 YAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEI 233
           + +DR+GR  +     L V + G   A AP F ++   RFL G+          +++ E 
Sbjct: 165 HLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAE- 223

Query: 234 VGSKQRRIVGIVIQMFFT-LGIIILPGIAYFIPNWQGIQLAITLPSF-LFLLYYWVVPES 291
             + + + +GI + M  + +  + L G+A+ I +W  +QL +++P F +FL   W++ ES
Sbjct: 224 WATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLL-ES 282

Query: 292 PRWLITRKKGDKALQILRRIAKCNG-----KYLSSNYSEITVTDE----EVSNPSFLDLV 342
            RWLI   K ++ L+ LR+ A  +G       L+    + T+  E    +   PS  +++
Sbjct: 283 ARWLIINNKPEEGLKELRKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEML 342

Query: 343 RTPQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIE 402
             P + K   +L F  F + + Y GL + +  +G N+++   + G V L    +    ++
Sbjct: 343 HMPNICKRISLLSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALK 402

Query: 403 RLGRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYP 462
            + RR        +  +  L   F+P+ +  LR  +ATLG     +A  + +   +E+ P
Sbjct: 403 YMNRRASQMLLMFLLAICLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIP 462

Query: 463 TTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKG 522
           T +R   + + +   +  G +AP ++  L+     LP II+G+   I G   +LLPET+ 
Sbjct: 463 TIIRARAMGINATFANIAGALAPLMMI-LSVYSPPLPWIIYGVFPFISGFAFLLLPETRN 521

Query: 523 IALPETVDD 531
             L +T+ D
Sbjct: 522 KPLFDTIQD 530


>gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]
          Length = 332

 Score =  162 bits (410), Expect = 7e-40
 Identities = 102/314 (32%), Positives = 163/314 (51%), Gaps = 17/314 (5%)

Query: 232 EIVGSKQRRIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPES 291
           E   ++ R +V  +  + F+ G  +   +AY + +W  +QL +++P FL  LY W + ES
Sbjct: 2   EWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAES 61

Query: 292 PRWLITRKKGDKALQILRRIAKCNGK-----------YLSSNYSEITVTDEEVSNPSFLD 340
            RWL+T  + D  LQ L R+A  NGK            LS+   E+++     S  +   
Sbjct: 62  ARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGT--- 118

Query: 341 LVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLT 400
           L+R P +R  T I    WF     + GL + L  +G N+++     GVV++P  +  LL 
Sbjct: 119 LLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLL 178

Query: 401 IERLGRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSEL 460
           +  LGRR   AAS ++AG+  L    +P  +  LR+ +A LG  G+  AF  + + +SEL
Sbjct: 179 LSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSEL 238

Query: 461 YPTTLRNFGVSLCSGLCDFGGIIAPFL-LFRLAAVWLELPLIIFGILASICGGLVMLLPE 519
           +PT LR   V L       G I+ P + L  +   W  LPL+++G +  + G   +LLPE
Sbjct: 239 FPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPW--LPLLVYGTVPVLSGLAALLLPE 296

Query: 520 TKGIALPETVDDVE 533
           T+ + LP+T+ DV+
Sbjct: 297 TQSLPLPDTIQDVQ 310


>gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6
           [Homo sapiens]
          Length = 560

 Score =  144 bits (362), Expect = 3e-34
 Identities = 130/475 (27%), Positives = 206/475 (43%), Gaps = 27/475 (5%)

Query: 83  PPERRGRCQRYLLEAANDSASATSALSCADPLAAF-PNRSAPLV--PCRGGWRYAQAHST 139
           PP  R      LL+AA      T A S   PL    P+  APL   P    W      + 
Sbjct: 58  PPALRALRGPALLDAAIPRLGPTRAASPCLPLGVLSPSYLAPLTRAPRPSSWASCSG-AA 116

Query: 140 IVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGVVV 199
               ++LVC + W + L Q    LG+L G   LG   DR+GR  +++ S +     G   
Sbjct: 117 AGPTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASE 176

Query: 200 AFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFTLGIIILPG 259
           A A +FP  ++ R L G    G  +  Y+   E+     R    +   +F  +G ++LPG
Sbjct: 177 ALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPG 236

Query: 260 IAYFIPNWQGIQLAITLPSFLFLLYYW---VVPESPRWLITRKKGDKALQILRRIAKCNG 316
           +A  + +W+ +Q    L S L LL++    + PESP WL+   +  +A +IL R A+ +G
Sbjct: 237 LAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASG 296

Query: 317 -----KYLSSN----YSEITVTDEEVSNPSF---LDLVRTPQMRKCTLILMFAWFTSAVV 364
                  L  N     +E+T+       P +   L L+RT    +  LIL F+      +
Sbjct: 297 VGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGI 356

Query: 365 YQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLV- 423
                  L       Y+ +F+   +E    + +LLT +  GRR       +V G+A L+ 
Sbjct: 357 RASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLL 416

Query: 424 ---TAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFG 480
                +LP    W    ++ LG L       +  L  +E++PT +R  G+ L  G   F 
Sbjct: 417 LAGAQYLP---GWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLG-AGFL 472

Query: 481 GIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKL 535
           G  A  L          L  ++F  LA +    V+LLPE++   LP+++ D ++L
Sbjct: 473 GQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRL 527


>gi|63999576 solute carrier family 22, member 17 isoform b [Homo
           sapiens]
          Length = 520

 Score =  143 bits (360), Expect = 5e-34
 Identities = 143/469 (30%), Positives = 208/469 (44%), Gaps = 43/469 (9%)

Query: 102 ASATSALSCADPLAAF--PNRSAPLVP----CRGGWRY---AQAHSTIVSEFDLVCVNAW 152
           ASA  A S A  +A    P+ S    P    C   W Y       +  + ++DLVC   W
Sbjct: 39  ASAALAASAASRVATSTDPSCSGFAPPDFNHCLKDWDYNGLPVLTTNAIGQWDLVCDLGW 98

Query: 153 MLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFR 212
            + L Q +  LGF +G   LGY ADR+GR  I LL+   VG  GV  A A +    +  R
Sbjct: 99  QVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALR 158

Query: 213 FLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQL 272
           FL G    G  +  Y++  E+    QR  V +  ++    G  +  G+A    +W+ +Q 
Sbjct: 159 FLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQR 218

Query: 273 AITLPSFLFLLYYW--VVPESPRWLITRKKGDKALQILRRIAKCN---GKYLSSNYSEI- 326
            IT P  LFL Y W  +  ES RWLI +++ ++A  +LR +A+ N   G+ L     E  
Sbjct: 219 MITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNRPHGQMLGEEAQEAL 278

Query: 327 -----TVTDEEVSNPSFLDLVRTPQMRKCTLILMFAWFTSAVV---YQGLVMRLGIIGGN 378
                T      S+ SF  L+    + K  LIL F  F +  +   YQ       + GG 
Sbjct: 279 QDLENTCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCYQ------PVGGGG 332

Query: 379 LYIDFFI-----SGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLVTA----FLPE 429
              DF++     SG   L   + + +T++R GRR     S  + G+A LV      +L E
Sbjct: 333 SPSDFYLCSLLASGTAAL-ACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDYLNE 391

Query: 430 GIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLF 489
                 TT + LG      A  +  L+ +E+ PTT+R  G+ L   L   GG+  P    
Sbjct: 392 AAI---TTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRL 448

Query: 490 RLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKLGSP 538
            +      L  ++    A +C   +MLLPETK   LPE + D E    P
Sbjct: 449 HMGH-GAFLQHVVLAACALLCILSIMLLPETKRKLLPEVLRDGELCRRP 496


>gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1
           [Homo sapiens]
          Length = 558

 Score =  138 bits (348), Expect = 1e-32
 Identities = 126/476 (26%), Positives = 202/476 (42%), Gaps = 31/476 (6%)

Query: 83  PPERRGRCQRYLLEAA----NDSASATSALSCADPLAAFPNRSAPLVPCRGGWRYAQAHS 138
           PP  R      LL+AA      + +   AL    P    P   AP          A A  
Sbjct: 58  PPALRALRGPALLDAAIPRLGPTRAPAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAGP 117

Query: 139 TIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGVV 198
           T    ++LVC + W + L Q    LG+L G   LG   DR+GR  +++ S +     G  
Sbjct: 118 T----WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGAS 173

Query: 199 VAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFTLGIIILP 258
            A A +FP  ++ R L G    G  +  Y+   E+     R    +   +F  +G ++LP
Sbjct: 174 EALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLP 233

Query: 259 GIAYFIPNWQGIQLAITLPSFLFLLYYW---VVPESPRWLITRKKGDKALQILRRIAKCN 315
           G+A  + +W+ +Q    L S L LL++    + PESP WL+   +  +A +IL R A+ +
Sbjct: 234 GLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEAS 293

Query: 316 G-----KYLSSN----YSEITVTDEEVSNPSF---LDLVRTPQMRKCTLILMFAWFTSAV 363
           G       L  N     +E+T+       P +   L L+RT    +  LIL F+      
Sbjct: 294 GVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGG 353

Query: 364 VYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLV 423
           +       L       Y+ +F+   +E    + +LLT +  GRR       +V G+A L+
Sbjct: 354 IRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLL 413

Query: 424 ----TAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDF 479
                 +LP    W    ++ LG L       +  L  +E++PT +R  G+ L  G    
Sbjct: 414 LLAGAQYLP---GWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFL 470

Query: 480 GGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKL 535
           G    P            L  ++F  LA +    V+LLPE++   LP+++ D ++L
Sbjct: 471 GQAAGPLDTLH-GRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRL 525


>gi|21361834 solute carrier family 22, member 17 isoform a [Homo
           sapiens]
          Length = 538

 Score =  138 bits (347), Expect = 2e-32
 Identities = 143/484 (29%), Positives = 209/484 (43%), Gaps = 55/484 (11%)

Query: 102 ASATSALSCADPLAAF--PNRSAPLVP----CRGGWRY---AQAHSTIVSEFDLVCVNAW 152
           ASA  A S A  +A    P+ S    P    C   W Y       +  + ++DLVC   W
Sbjct: 39  ASAALAASAASRVATSTDPSCSGFAPPDFNHCLKDWDYNGLPVLTTNAIGQWDLVCDLGW 98

Query: 153 MLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFR 212
            + L Q +  LGF +G   LGY ADR+GR  I LL+   VG  GV  A A +    +  R
Sbjct: 99  QVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALR 158

Query: 213 FLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQL 272
           FL G    G  +  Y++  E+    QR  V +  ++    G  +  G+A    +W+ +Q 
Sbjct: 159 FLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQR 218

Query: 273 AITLPSFLFLLYYW--VVPESPRWLITRKKGDKALQILRRIAKCN---GKYLSSNYSEI- 326
            IT P  LFL Y W  +  ES RWLI +++ ++A  +LR +A+ N   G+ L     E  
Sbjct: 219 MITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNRPHGQMLGEEAQEAL 278

Query: 327 -----TVTDEEVSNPSFLDLVRTPQMRKCTLILMFAWFTSAVV---YQGLVMRLGIIGGN 378
                T      S+ SF  L+    + K  LIL F  F +  +   YQ       + GG 
Sbjct: 279 QDLENTCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCYQ------PVGGGG 332

Query: 379 LYIDFFI-----SGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLVTAFLPE---- 429
              DF++     SG   L   + + +T++R GRR     S  + G+A LV   L +    
Sbjct: 333 SPSDFYLCSLLASGTAAL-ACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDCEHP 391

Query: 430 --GIAWLR-------------TTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCS 474
                W +             TT + LG      A  +  L+ +E+ PTT+R  G+ L  
Sbjct: 392 IFPTVWAQQGNPNRDLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIM 451

Query: 475 GLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEK 534
            L   GG+  P     +      L  ++    A +C   +MLLPETK   LPE + D E 
Sbjct: 452 ALGALGGLSGPAQRLHMGH-GAFLQHVVLAACALLCILSIMLLPETKRKLLPEVLRDGEL 510

Query: 535 LGSP 538
              P
Sbjct: 511 CRRP 514


>gi|170650643 solute carrier family 22, member 23 isoform a [Homo
           sapiens]
          Length = 686

 Score =  132 bits (333), Expect = 6e-31
 Identities = 138/556 (24%), Positives = 238/556 (42%), Gaps = 51/556 (9%)

Query: 15  GRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERCGWSPEEEWNRT 74
           G +Q+ + LL  +  +   F      FL  QP+ +WCRG  A    E  G +        
Sbjct: 93  GGYQKTLVLLTWIPALFIGFSQFSDSFLLDQPN-FWCRG--AGKGTELAGVTTTGRGGDM 149

Query: 75  APASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNR--SAPLVPCRGGWR 132
              +  P  P      +     A N S S+ +      PL + P++  +A    CR  W 
Sbjct: 150 GNWTSLPTTPFATAPWEA----AGNRSNSSGADGGDTPPLPSPPDKGDNASNCDCRA-WD 204

Query: 133 Y---AQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSC 189
           Y   A     +VS++DLVC NAW + + +  L +G + G    G  AD  GR  + L S 
Sbjct: 205 YGIRAGLVQNVVSKWDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSI 264

Query: 190 LGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMF 249
           + + + G+ VA + N  +F   RF +G    G  +T Y +  E+    +R ++ +V    
Sbjct: 265 IFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFV 324

Query: 250 FTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILR 309
              G  ++PG+A    +WQ +Q  I  P  L LLY+ + PES RWL+  ++ + A +++ 
Sbjct: 325 AMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLIL 384

Query: 310 RIAKCNGKYLSSNY-SEITVTDEEVS----NPSFLDLVRTPQMRKCTLILMFAWFTSAVV 364
              + N      +    I   ++E+S        + +V T  + K  ++L     T   +
Sbjct: 385 HFTQKNRMNPEGDIKGVIPELEKELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGI 444

Query: 365 Y-------QGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRR--------LP 409
           +        G  +++ ++  N Y D++ +  + L   L + + +  LGRR        L 
Sbjct: 445 HHCFARSMMGHEVKVPLL-ENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILT 503

Query: 410 FAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNS----------- 458
             AS +  G+  L+  +     + +  +V    +   ++AF IV +  S           
Sbjct: 504 ALASLLQLGLLNLIGKYSQHPDSGMSDSV----KDKFSIAFSIVGMFASHAVGSLSVFFC 559

Query: 459 -ELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLL 517
            E+ PT +R  G+ L      FG + AP +       +  L  IIF     IC   ++LL
Sbjct: 560 AEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYF-LHHIIFACCTLICIICILLL 618

Query: 518 PETKGIALPETVDDVE 533
           PE++   LPE + + E
Sbjct: 619 PESRDQNLPENISNGE 634


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.328    0.143    0.456 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,260,535
Number of Sequences: 37866
Number of extensions: 949374
Number of successful extensions: 3179
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 44
Number of HSP's successfully gapped in prelim test: 34
Number of HSP's that attempted gapping in prelim test: 2959
Number of HSP's gapped (non-prelim): 115
length of query: 556
length of database: 18,247,518
effective HSP length: 107
effective length of query: 449
effective length of database: 14,195,856
effective search space: 6373939344
effective search space used: 6373939344
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.