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Search of human proteins with 21361348
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21361348 UTP14, U3 small nucleolar ribonucleoprotein,
homolog A [Homo sapiens]
(771 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21361348 UTP14, U3 small nucleolar ribonucleoprotein, homolog... 1505 0.0
gi|51871374 UTP14, U3 small nucleolar ribonucleoprotein, homolog... 1349 0.0
gi|221219020 NYD-SP11 protein [Homo sapiens] 78 3e-14
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 68 4e-11
gi|148746195 trichohyalin [Homo sapiens] 67 5e-11
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 64 4e-10
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 64 4e-10
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 64 4e-10
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 64 4e-10
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 64 4e-10
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 64 4e-10
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 64 4e-10
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 64 4e-10
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 64 5e-10
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 64 5e-10
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 64 7e-10
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 64 7e-10
gi|104526627 triadin [Homo sapiens] 63 9e-10
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 62 3e-09
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 61 3e-09
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 61 3e-09
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 61 3e-09
gi|45439327 periplakin [Homo sapiens] 60 6e-09
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 59 1e-08
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 59 1e-08
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 58 4e-08
gi|31982906 cingulin-like 1 [Homo sapiens] 58 4e-08
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 57 5e-08
gi|71061468 centromere protein E [Homo sapiens] 57 5e-08
gi|32698688 citron [Homo sapiens] 57 6e-08
>gi|21361348 UTP14, U3 small nucleolar ribonucleoprotein, homolog A
[Homo sapiens]
Length = 771
Score = 1505 bits (3897), Expect = 0.0
Identities = 771/771 (100%), Positives = 771/771 (100%)
Query: 1 MTANRLAESLLALSQQEELADLPKDYLLSESEDEGDNDGERKHQKLLEAISSLDGKNRRK 60
MTANRLAESLLALSQQEELADLPKDYLLSESEDEGDNDGERKHQKLLEAISSLDGKNRRK
Sbjct: 1 MTANRLAESLLALSQQEELADLPKDYLLSESEDEGDNDGERKHQKLLEAISSLDGKNRRK 60
Query: 61 LAERSEASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSSLATVKKQLSRVKSKKTVELPL 120
LAERSEASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSSLATVKKQLSRVKSKKTVELPL
Sbjct: 61 LAERSEASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSSLATVKKQLSRVKSKKTVELPL 120
Query: 121 NKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVLSGWKA 180
NKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVLSGWKA
Sbjct: 121 NKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVLSGWKA 180
Query: 181 RTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAELQRARALQSYYEAK 240
RTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAELQRARALQSYYEAK
Sbjct: 181 RTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAELQRARALQSYYEAK 240
Query: 241 ARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERMSLKHQ 300
ARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERMSLKHQ
Sbjct: 241 ARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERMSLKHQ 300
Query: 301 NSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESEEEEGGTEDVEELLVPD 360
NSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESEEEEGGTEDVEELLVPD
Sbjct: 301 NSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESEEEEGGTEDVEELLVPD 360
Query: 361 VVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGVSESEGEERPVAEEEIL 420
VVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGVSESEGEERPVAEEEIL
Sbjct: 361 VVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGVSESEGEERPVAEEEIL 420
Query: 421 LREFEERRSLRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASS 480
LREFEERRSLRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASS
Sbjct: 421 LREFEERRSLRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASS 480
Query: 481 EGTIPQVQREEPAPEEEEPLLLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQSER 540
EGTIPQVQREEPAPEEEEPLLLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQSER
Sbjct: 481 EGTIPQVQREEPAPEEEEPLLLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQSER 540
Query: 541 TPNNRPDAPKEKKKKEQMIDLQNLLTTQSPSVKSLAVPTIEELEDEEERNHRQMIKEAFA 600
TPNNRPDAPKEKKKKEQMIDLQNLLTTQSPSVKSLAVPTIEELEDEEERNHRQMIKEAFA
Sbjct: 541 TPNNRPDAPKEKKKKEQMIDLQNLLTTQSPSVKSLAVPTIEELEDEEERNHRQMIKEAFA 600
Query: 601 GDDVIRDFLKEKREAVEASKPKDVDLTLPGWGEWGGVGLKPSAKKRRRFLIKAPEGPPRK 660
GDDVIRDFLKEKREAVEASKPKDVDLTLPGWGEWGGVGLKPSAKKRRRFLIKAPEGPPRK
Sbjct: 601 GDDVIRDFLKEKREAVEASKPKDVDLTLPGWGEWGGVGLKPSAKKRRRFLIKAPEGPPRK 660
Query: 661 DKNLPNVIINEKRNIHAAAHQVRVLPYPFTHHWQFERTIQTPIGSTWNTQRAFQKLTTPK 720
DKNLPNVIINEKRNIHAAAHQVRVLPYPFTHHWQFERTIQTPIGSTWNTQRAFQKLTTPK
Sbjct: 661 DKNLPNVIINEKRNIHAAAHQVRVLPYPFTHHWQFERTIQTPIGSTWNTQRAFQKLTTPK 720
Query: 721 VVTKPGHIINPIKAEDVGYRSSSRSDLSVIQRNPKRITTRHKKQLKKCSVD 771
VVTKPGHIINPIKAEDVGYRSSSRSDLSVIQRNPKRITTRHKKQLKKCSVD
Sbjct: 721 VVTKPGHIINPIKAEDVGYRSSSRSDLSVIQRNPKRITTRHKKQLKKCSVD 771
>gi|51871374 UTP14, U3 small nucleolar ribonucleoprotein, homolog C
[Homo sapiens]
Length = 766
Score = 1349 bits (3492), Expect = 0.0
Identities = 692/767 (90%), Positives = 729/767 (95%), Gaps = 3/767 (0%)
Query: 1 MTANRLAESLLALSQQEELADLPKDYLLSESEDEGDNDGERKHQKLLEAISSLDGKNRRK 60
M N++AE+L ALS QEEL DLPK+Y LSE+EDEGD+DGERKHQKLLEAI SLDGKNRRK
Sbjct: 1 MNVNQVAENL-ALSHQEELVDLPKNYPLSENEDEGDSDGERKHQKLLEAIISLDGKNRRK 59
Query: 61 LAERSEASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSSLATVKKQLSRVKSKKTVELPL 120
LAERSEASLKVSEF+VSSEGSGEKL LADLLEPVKTSSSLATVKKQL+RVKSKK VELPL
Sbjct: 60 LAERSEASLKVSEFSVSSEGSGEKLGLADLLEPVKTSSSLATVKKQLNRVKSKKVVELPL 119
Query: 121 NKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVLSGWKA 180
NKE+IE+IHREVAF+KT+QVLSKWDP++LKN+QAEQLVFPL KE+PAIAPIEH LSGWKA
Sbjct: 120 NKEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALSGWKA 179
Query: 181 RTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAELQRARALQSYYEAK 240
RTPLEQEIFNLLHKNKQPVTDPLLTP+EKASL+AMSLEEAKM RAELQRARALQSYYEAK
Sbjct: 180 RTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEEAKMHRAELQRARALQSYYEAK 239
Query: 241 ARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERMSLKHQ 300
AR+EKKIKSKKYHKVVKKGKAKKALKEFEQL+KVNP ALEE+EKIE ARMMERMSLKHQ
Sbjct: 240 ARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEKIENARMMERMSLKHQ 299
Query: 301 NSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESEEEEGGTEDVEELLVPD 360
NSGKWAKSKAIMAKYDLEARQAMQEQL+KNKELTQKLQVASESEEEEGGTE VEELLVP
Sbjct: 300 NSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVASESEEEEGGTE-VEELLVPH 358
Query: 361 VVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGVSESEGEERPVAEEEIL 420
V NEVQMN DGPNPWM RSCTSDTKEAATQEDPEQ+PEL AH VS SE EERPVAEEEIL
Sbjct: 359 VANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSASEAEERPVAEEEIL 418
Query: 421 LREFEERRSLRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASS 480
LREFEER+SLRKRSEL+QDAEPA SQETKDS SQEVLSELR LSQKLKE HQSRKQKASS
Sbjct: 419 LREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQKASS 478
Query: 481 EGTIPQVQREEPAPEEEEPLLLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQSER 540
EGT+PQVQREEPAPEE EPLLLQR ERVQTLEELEELGKE+CFQNKELPRPVLEGQQSER
Sbjct: 479 EGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELPRPVLEGQQSER 538
Query: 541 TPNNRPDAPKEKKKKEQMIDLQNLLTTQSPSVKSLAVPT-IEELEDEEERNHRQMIKEAF 599
TPNNRPDAPKEKK+KEQ+I+LQN LTTQSPSV+SLAVPT IEELEDEEER+ RQMIKEAF
Sbjct: 539 TPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEERDQRQMIKEAF 598
Query: 600 AGDDVIRDFLKEKREAVEASKPKDVDLTLPGWGEWGGVGLKPSAKKRRRFLIKAPEGPPR 659
AGDDVIRDFLKEKREAVEASKPKDVDLTLPGWGEWGGVGLKPSAKKRR+FLIKAPEGPPR
Sbjct: 599 AGDDVIRDFLKEKREAVEASKPKDVDLTLPGWGEWGGVGLKPSAKKRRQFLIKAPEGPPR 658
Query: 660 KDKNLPNVIINEKRNIHAAAHQVRVLPYPFTHHWQFERTIQTPIGSTWNTQRAFQKLTTP 719
KDKNLPNVII+EKRNIHAAAHQV+VLPYPFTHH QFERTIQTPIGSTWNTQRAFQKLTTP
Sbjct: 659 KDKNLPNVIISEKRNIHAAAHQVQVLPYPFTHHRQFERTIQTPIGSTWNTQRAFQKLTTP 718
Query: 720 KVVTKPGHIINPIKAEDVGYRSSSRSDLSVIQRNPKRITTRHKKQLK 766
KVVTKPGHII PIKAEDVGY+SSSRSDL VIQRNPKRITTRH K+ K
Sbjct: 719 KVVTKPGHIIKPIKAEDVGYQSSSRSDLPVIQRNPKRITTRHNKEEK 765
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 78.2 bits (191), Expect = 3e-14
Identities = 145/640 (22%), Positives = 268/640 (41%), Gaps = 82/640 (12%)
Query: 5 RLAESLLALSQQEELADLPKDYLLSESEDEGDNDGE--RKHQKLLEAISSLDGKNRRKLA 62
+L+E L+Q+EEL K+ L E + + RK ++L+E + KLA
Sbjct: 1762 KLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIE--------KKMKLA 1813
Query: 63 ERSEASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSSLATVKKQLSRVKSKKTVELPLNK 122
++ E + N E + K++L + +LA K++L++ K L NK
Sbjct: 1814 QKRERWI-----NSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKEN----LLYNK 1864
Query: 123 EEIERIHREVA--------FNKT-AQVLSKW----DPVVLKNRQAEQLVFPLEKEEPAIA 169
E + +++ FNK AQV K + V+ K + + L + E ++A
Sbjct: 1865 ERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLA 1924
Query: 170 PIEHVLSGWKARTPLEQEIFNLLHKNKQPVTDPL-LTPVEKA-SLRAMSLEEAKMRRAEL 227
+ L+ K + LE+ + + K+ + L + EKA +L L E KMR E
Sbjct: 1925 KKQEKLAQEKMKLALEKAMV----QGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEG 1980
Query: 228 QRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIE 287
+ + K + + +K +V ++ +K E + L + A+EE E +
Sbjct: 1981 KETLS-------KGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAK 2033
Query: 288 -KARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESE-- 344
K + Q K AK+ + K R+++ ++ +K ++ + LQ + E
Sbjct: 2034 GKLEFTRGQRIFVQGQRKLAKASRKLIK----KRESLSKEPAKLNKILKALQKLTRDERK 2089
Query: 345 ---EEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQLPELEA 401
EE T+ L V + ++ + W K + +D ++L +
Sbjct: 2090 LTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSE-----KRSELTKDEKKLARKQR 2144
Query: 402 HGVSESEGEERPVAEEEILLREFEERRSLRKRSELSQDAEPAGSQETKDSGSQEVLSELR 461
++ R + +EE + E E + RK SE+ D E G E +EV+ L+
Sbjct: 2145 KLANKMR---RMINKEEKMTEE--ESKLARKHSEVILDDEEEGGIE-----EEEVIPFLK 2194
Query: 462 VLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLL--LQRPERV-----QTLEEL 514
+K KE + K K + +V+ EE EE E LL L++ E + + EE
Sbjct: 2195 RRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEE 2254
Query: 515 EELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMIDLQNLLTTQSPSVKS 574
EE +EE + +E + EG+ E+ + K+KKK+++ ++Q +
Sbjct: 2255 EEREEEEVREEEEERKEEEEGE--EKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEI 2312
Query: 575 LAVPTIEELEDEEERNHRQMIKEAFAGDDVIRDFLKEKRE 614
++ E L DEEE ++E D ++ LK++++
Sbjct: 2313 MSEEETESLSDEEEEEESCSLEEEV---DREKEILKKEKQ 2349
Score = 53.9 bits (128), Expect = 5e-07
Identities = 92/428 (21%), Positives = 182/428 (42%), Gaps = 55/428 (12%)
Query: 215 MSLEEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKV 274
++LEE R E + Q E + +++ K + H+ + + K+A +E +L +
Sbjct: 1544 VTLEEEVSREGEEKE----QQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEE-RKLAQE 1598
Query: 275 NPAAALEELEKIEKARMMERMSLK--------HQNSGKWAKSKAIMAKYDLEARQAMQEQ 326
A EE + ++ R + + +K Q GK+A+ + +A+ + Q ++
Sbjct: 1599 EEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKL 1658
Query: 327 LSKNKELTQKLQVASESEEE----EGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTS 382
K K+L +K + + EE+ G +V+ +L V Q R
Sbjct: 1659 AQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQ-----------REQNL 1707
Query: 383 DTKEAATQEDPEQLPELEAHGVSESEGEERPVAEEEILLREFEERRSLRKRSELSQDAEP 442
D +E ++ E+L E + EE EEE+ EE + + ++ +L+++ E
Sbjct: 1708 DWQEKELAQELEEL---------EWDMEELSWKEEEL---NQEEGKLVEEKKKLAEEEEA 1755
Query: 443 AGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLL 502
Q K S + L++ L + KE K+K E ++ R+ E++ L
Sbjct: 1756 LAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEE--ERLGRKREQLIEKKMKLA 1813
Query: 503 QRPER-VQTLEELEELGKEECFQNKELPRPVLE-GQQSERTPNNRPDAPKEKKK----KE 556
Q+ ER + ++EEL + K +Q K L + Q+ E+ + + K++ K+
Sbjct: 1814 QKRERWINSMEELTK-NKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKK 1872
Query: 557 QMIDLQNLLTTQSPSVKSLAVPTIEELEDEEERNHRQMIKEAFAGDDVIR--DFLKEKRE 614
Q++ ++N L + E+L E+E ++ K A +++ D L +K+E
Sbjct: 1873 QLVQVKNKL----GMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQE 1928
Query: 615 AVEASKPK 622
+ K K
Sbjct: 1929 KLAQEKMK 1936
Score = 47.0 bits (110), Expect = 7e-05
Identities = 83/394 (21%), Positives = 160/394 (40%), Gaps = 46/394 (11%)
Query: 184 LEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAELQRARALQSYYEAKARR 243
LE+E+ + +Q VT+ E+ + + A+ + Q R L E A+
Sbjct: 1546 LEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQE 1605
Query: 244 EKKIKSKK------YHKVVK------KGKAKKALKE---FEQLRKVNPAAALEELEKIEK 288
E+++ ++ Y K+ + + + K A KE ++ K++ A ++ +
Sbjct: 1606 ERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKL 1665
Query: 289 ARMMERMSLKHQ----NSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESE 344
A+ E+++ + + GK A+ K I+A+ E Q Q + KEL Q+L+
Sbjct: 1666 AKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDM 1725
Query: 345 EEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGV 404
EE E+ +V E + A+ +E A E+L E E
Sbjct: 1726 EELSWKEEELNQEEGKLVEEKKKLAE--------------EEEALAWQREKLSEEETKLA 1771
Query: 405 SESE---GEERPVAEEEILLREFEERRSLRKRSELSQDAEPAGSQETKDSGSQEVLSELR 461
E E E+ +A+ + + E EER RKR +L + + + S E L++ +
Sbjct: 1772 QEEELLIQEKEKLAQHKEKMPEEEERLG-RKREQLIEKKMKLAQKRERWINSMEELTKNK 1830
Query: 462 VLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLLQRPERVQTLEELEELGKEE 521
++ + K Q +K A Q +E + +E LL + + ++L ++ +
Sbjct: 1831 MILYQKKNLAQEKKNLA---------QEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKL 1881
Query: 522 CFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKK 555
NK L + + Q + T + + E +KK
Sbjct: 1882 GMFNKILAQVEEKLTQEKETVIKKKEKLAETEKK 1915
Score = 45.4 bits (106), Expect = 2e-04
Identities = 78/405 (19%), Positives = 165/405 (40%), Gaps = 36/405 (8%)
Query: 245 KKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEEL---EKIEKARMMERMSLKHQN 301
KK + K + K K+G+ KA+++ ++ K+ EE E++E+ +E +K +
Sbjct: 1389 KKEEKKTFQKSPKQGR--KAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQE- 1445
Query: 302 SGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESEE-----EEGGTEDVEEL 356
GK + + D ++A E + E + + E E EE E
Sbjct: 1446 -GKLVMIERTPSWQDW--KKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEK 1502
Query: 357 LVPDVVNEVQMNADGPNPW-----MLRSCTSDTKEAATQEDPEQLPELEAHGVSESEGEE 411
L P+ E + D W + + S + +D E++ LE E E +E
Sbjct: 1503 LSPE---EEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVT-LEEEVSREGEEKE 1558
Query: 412 RPVAEEEILLRE------FEERRSLRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQ 465
+ V EE+ ++E +R+ ++ ++ + A +E +++ E R L+Q
Sbjct: 1559 QQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQ 1618
Query: 466 KLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLLQRPERVQTLEELEELGKEECFQN 525
+ Q ++ A +EG Q+EE + E L + + Q ++L + ++ +
Sbjct: 1619 AYVKITQDDREMAQAEGKF--AQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREE 1676
Query: 526 KELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMIDLQNLLTTQSPSVKSLAVPTIEELED 585
++L + +G + N +E ++EQ +D Q Q + + E+
Sbjct: 1677 EKLAK---KGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEE 1733
Query: 586 EEERNHRQMI--KEAFAGDDVIRDFLKEKREAVEASKPKDVDLTL 628
E + +++ K+ A ++ + +EK E ++ +L +
Sbjct: 1734 ELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLI 1778
Score = 30.8 bits (68), Expect = 5.0
Identities = 39/199 (19%), Positives = 83/199 (41%), Gaps = 28/199 (14%)
Query: 240 KARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEK--ARMMERMSL 297
K R K+ ++K+ K +K ++ E E+ + L+ELEK E + E
Sbjct: 2194 KRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREE 2253
Query: 298 KHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESEEEEGGTEDVEELL 357
+ + + + + K + E + E+ + K+ +K + E +E+E E+ EE++
Sbjct: 2254 EEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIM 2313
Query: 358 VPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGVSESEGEERPVAEE 417
+ +T+ + +E+ E+ LE E + E+ + +E
Sbjct: 2314 SEE----------------------ETESLSDEEEEEESCSLE----EEVDREKEILKKE 2347
Query: 418 EILLREFEERRSLRKRSEL 436
+ + + R+SLR R +
Sbjct: 2348 KQFKLQEQRRKSLRGRERV 2366
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 67.8 bits (164), Expect = 4e-11
Identities = 125/602 (20%), Positives = 229/602 (38%), Gaps = 88/602 (14%)
Query: 28 LSESEDEGDNDGERKHQKLLEAISSLDGKNRRKLAERSEASLKVSEFNVSSEGSGEKLVL 87
++E E++ + E K ++ E + G+ K EA+ S E + V
Sbjct: 470 VTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAA--------SPEKEAKSPVK 521
Query: 88 ADLLEPVKTSSSLATVKKQLSRVKSKKTVELPLNKEEIERIHREVAFNKTAQVLSKWDPV 147
+ P + S K + VKS + + P KEE + P
Sbjct: 522 EEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPA-KEEAK------------------SPP 562
Query: 148 VLKNRQAEQLVFPLEKEEPAIAPI---EHVLSGWKARTPLEQEIFNLLHKNKQPVTDPLL 204
K+ + E+ P E + P A E S +A++P K K PV +
Sbjct: 563 EAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSP---------EKAKSPVKEEAK 613
Query: 205 TPVEKASLRAMSLEEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKA 264
+P E S ++E AE++ +S + +A+ +K KS + + KAK
Sbjct: 614 SPAEAKS----PVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSP 669
Query: 265 LKEFEQLRKVNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQ 324
+K + + + E + EKA+ + K K + AK +A+ ++
Sbjct: 670 VKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEE--AKSPEKAKSPVK 727
Query: 325 EQLSKNKELTQKLQVASESEEEEGGTEDVEELLV--PDVVNEVQMNADGPNPWMLRSCTS 382
E+ ++ ++ ++S E+ E + L V P+ + A P S
Sbjct: 728 EEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKS 787
Query: 383 DTKEAATQEDPEQLPELEAHGVSESEGEERPVAEEEILLREFEERRSLRKRSELSQDAEP 442
KE + + P E +++ E+ + ++E + +E K E+ P
Sbjct: 788 PVKEEVKSPEKAKSPLKE-----DAKAPEKEIPKKEEVKSPVKEEE---KPQEVKVKEPP 839
Query: 443 AGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLL 502
++E K + K +E S+K++A P+ + +P EE++ +
Sbjct: 840 KKAEEEKAPATP-----------KTEEKKDSKKEEA------PKKEAPKPKVEEKKEPAV 882
Query: 503 QRPERVQTLEELEELGKEECFQNKELPRPVLEG-QQSERTPNNRPDAPKEKKKKEQMIDL 561
++P+ E E KEE K++P P E + E + +P E KKE D
Sbjct: 883 EKPK-----ESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEP--DD 935
Query: 562 QNLLTTQSPSVKSLAVPTIEELEDEEERNHRQMIK-EAFAGDDVIRDFLKEKREAVEASK 620
P+ K A P ++ ++E+ + + K EA A +D +K + E SK
Sbjct: 936 AKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKED-------DKTLSKEPSK 988
Query: 621 PK 622
PK
Sbjct: 989 PK 990
Score = 60.1 bits (144), Expect = 8e-09
Identities = 97/432 (22%), Positives = 166/432 (38%), Gaps = 27/432 (6%)
Query: 246 KIKSKKYHKVVKKGKAKKALKE--FEQLRKVNPAAALEELEKIEKARMMERMSLKHQNSG 303
K+KS++ KVV+K + + + E E+ + EE E E+ E + + G
Sbjct: 437 KVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEG 496
Query: 304 KWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESEEEEGGTEDVEELLVPDVVN 363
++K+ A+ EA +E S KE + A E+EE + E+ P+
Sbjct: 497 GEEETKSPPAE---EAASPEKEAKSPVKEEAKSPAEAKSPEKEEA--KSPAEVKSPEKAK 551
Query: 364 EVQMNADGPNPWMLRSCTSDTKEAATQEDPEQLP---ELEAHGVSESEGEER---PVAEE 417
P + K A + PE+ + EA +E++ E+ PV EE
Sbjct: 552 SPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEE 611
Query: 418 EILLREFEERRSLRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQK 477
+ E +S K E AE ++ K +E S + S + +E K K
Sbjct: 612 A---KSPAEAKSPVKE-EAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAK 667
Query: 478 A--SSEGTIPQVQREEPAPEEEEPLLLQRP--ERVQTLEELEELGKEECFQNKELPRPVL 533
+ +E P+ + E + P + P E ++ E+ + KEE ++ PV
Sbjct: 668 SPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVK 727
Query: 534 EGQQSERTPNNRPDAPKEKKK---KEQMIDLQNLLTTQSPSVKSLAVPTIEELEDEEERN 590
E +TP KE+ K K + + L +SP K+ A D+
Sbjct: 728 E---EAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEK 784
Query: 591 HRQMIKEAFAGDDVIRDFLKEKREAVEASKPKDVDLTLPGWGEWGGVGLKPSAKKRRRFL 650
+ +KE + + LKE +A E PK ++ P E +K ++
Sbjct: 785 AKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEE 844
Query: 651 IKAPEGPPRKDK 662
KAP P ++K
Sbjct: 845 EKAPATPKTEEK 856
Score = 46.2 bits (108), Expect = 1e-04
Identities = 60/310 (19%), Positives = 112/310 (36%), Gaps = 32/310 (10%)
Query: 322 AMQEQLSKNKELTQKLQVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCT 381
++ E L K ++ ++V SE + + + E ++V + E Q+
Sbjct: 421 SLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVT------------- 467
Query: 382 SDTKEAATQEDPEQLPELEAHGVSESEGEERPVAEEEILLREFEERRSLRKRSELSQDAE 441
E T+E+ ++ E E E EE EEE EE S K ++ E
Sbjct: 468 ----EEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEE 523
Query: 442 PAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLL 501
E K +E S V S + ++ + K+ E P+ + + E + P
Sbjct: 524 AKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEK 583
Query: 502 LQRPER--------VQTLEELEELGKEECFQNKELPRPVLEGQQSE---RTPNNRPDAPK 550
+ P + ++ E+ + KEE E PV E +S ++P K
Sbjct: 584 AKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTK 643
Query: 551 EKKKKEQMIDLQNLLTTQSPSVKSLAVPTIEELEDEEERNHRQMIKEAFAGDDVIRDFLK 610
E+ K + +SP V + E + + +K + + +K
Sbjct: 644 EEAKSPEKAKSPEKEEAKSPEKAKSPV----KAEAKSPEKAKSPVKAEAKSPEKAKSPVK 699
Query: 611 EKREAVEASK 620
E+ ++ E +K
Sbjct: 700 EEAKSPEKAK 709
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 67.4 bits (163), Expect = 5e-11
Identities = 125/599 (20%), Positives = 243/599 (40%), Gaps = 91/599 (15%)
Query: 8 ESLLALSQQEELADL--PKDYLLSESEDEGDNDGERKHQKLLEAISSLDGKNRRKLAERS 65
ESLL +QEE P+D L E G+R+ QK E R+LAE
Sbjct: 107 ESLLQDRRQEEDQRRFEPRDRQLEEEP------GQRRRQKRQE--------QERELAEGE 152
Query: 66 EASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSSLATVKKQLSRVKSKKTVELP----LN 121
E S K ++ + E + A ++QL K +T E P L
Sbjct: 153 EQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAE-EEQLQSCKGHETEEFPDEEQLR 211
Query: 122 KEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVLSGWKAR 181
+ E+ + R+ K Q R+ + VF E+E+ W+ R
Sbjct: 212 RRELLELRRKGREEKQQQ-----------RRERQDRVFQEEEEKE-----------WRKR 249
Query: 182 TPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAELQRARALQSYYEAKA 241
+L K ++ + + P + L+ + K+ R EL+R R + + +
Sbjct: 250 E-------TVLRKEEEKLQEE--EPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRL 300
Query: 242 RREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERMSLKHQN 301
RRE++++ K+ + + + ++ +E ++ R+ ++L + ++ R +++ + +
Sbjct: 301 RREQQLRRKQEEE---RREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEE 357
Query: 302 SGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESEEEEGGTEDVEELLVPDV 361
+ + + + E + ++QL + ++L ++ Q+ E + +
Sbjct: 358 ERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQ----------------L 401
Query: 362 VNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGVSESEGEERPVAEEEILL 421
E Q+ + LR +E + + E+ + H E E R E+ L
Sbjct: 402 RREQQLRREQ----QLRREQQLRREQQLRREQEEERHEQKH-----EQERR----EQRLK 448
Query: 422 REFEERRSLRKRSELSQDAEPAGSQETKDSGSQEVLSE--LRVLSQKLKENHQSRKQKAS 479
RE EERR KR E ++ E ++ +E E L++ ++ +E + R+Q+
Sbjct: 449 REQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLR 508
Query: 480 SEGTIPQVQREEPAPEEEEPLLLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQSE 539
E + QR + +EEE L QR Q L +E +E+ + +E R E ++ +
Sbjct: 509 REQEERREQRLKR--QEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQE-RREQ 565
Query: 540 RTPNNRPDAPKEKKKKEQMIDLQNLLTTQSPSVKS-LAVPTIEELEDEEERNHRQMIKE 597
R + + + K+E+ Q L Q ++ L +E LE +EER +++ +E
Sbjct: 566 RLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLE-QEERREQRLKRE 623
Score = 67.0 bits (162), Expect = 6e-11
Identities = 93/434 (21%), Positives = 181/434 (41%), Gaps = 45/434 (10%)
Query: 218 EEAKMRRAELQRARALQSYY---EAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKV 274
E K RR E +R + E + RE++ K ++ + + K KK ++ EQL
Sbjct: 917 EREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGE 976
Query: 275 NPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEAR-----QAMQEQLSK 329
P + E+ +K R E + + + + + K +++ + R Q +EQL +
Sbjct: 977 EPEKRRRQ-EREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLR 1035
Query: 330 NKELTQKLQVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAAT 389
+ ++LQ EE + EE L+ + E + + + +E
Sbjct: 1036 EEREKRRLQERERQYREEEELQQEEEQLLGEE-RETRRRQELERQYRKEEELQQEEEQLL 1094
Query: 390 QEDPEQLPELEAHGVSESEGEERPVAEEEILLREFEERR-------SLRKRSELSQDAEP 442
+E+PE+ E + EE EEE LLRE E+R R+ E+ Q+ E
Sbjct: 1095 REEPEKRRRQERE--RQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQ 1152
Query: 443 AGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLL 502
+E + QE+ + R + +E Q +Q E + +RE EEEE
Sbjct: 1153 LLREEPEKRRRQELERQYR----EEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQ 1208
Query: 503 QRPERVQTLEELEELG------KEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKE 556
+R +R + ++ +L KE ++ ++ +G+++E+ ++++ ++
Sbjct: 1209 KRKQRYRDEDQRSDLKWQWEPEKENAVRDNKV---YCKGRENEQFRQLEDSQLRDRQSQQ 1265
Query: 557 QMIDLQNLLTTQSP----------SVKSLAVPTIEELEDEEERNHRQMIKEAFAGDDVIR 606
DLQ+LL Q + P E+LE EE++ ++ +++ ++R
Sbjct: 1266 ---DLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLR 1322
Query: 607 DFLKEKREAVEASK 620
+ +EKR E +
Sbjct: 1323 EEREEKRRRQETDR 1336
Score = 65.5 bits (158), Expect = 2e-10
Identities = 123/593 (20%), Positives = 233/593 (39%), Gaps = 64/593 (10%)
Query: 24 KDYLLSESEDEGDNDGERKHQ-------KLLEAISSLDGKNRRKLAERSEASLKVSEFNV 76
+D+L E E E RK Q + E L+ + RR+ ER E L+ +
Sbjct: 455 RDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEER 514
Query: 77 SSEGSGEKLVLADLLEPVKTSSSLATVKKQLSRVKSKKTVELPLNKEEIERIHREVAFNK 136
+ + L + +++ L +++ K+ E L +E E+ + +
Sbjct: 515 REQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEER 574
Query: 137 TAQVLSKWDP---VVLKNRQAEQLVFPLEKEEPAIAPIEHVLSGWKARTPLEQEIFNLLH 193
Q+L + + LK Q E+L L++EE +E + + L++E
Sbjct: 575 RDQLLKREEERRQQRLKREQEERLEQRLKREE-----VERLEQEERREQRLKRE------ 623
Query: 194 KNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAELQRARALQSYYEAKARREKKIKSKKYH 253
P E+ + + EE + RR + R E + RRE+++K ++
Sbjct: 624 -----------EPEEERRQQLLKSEEQEERRQQQLRR-------EQQERREQRLKREEEE 665
Query: 254 KVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARM-MERMSLKHQNSGKWAKSKAIM 312
+ +++ + +E E+ R+ A E+ + E+ + + + + ++ +SK
Sbjct: 666 ERLEQ----RLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYS 721
Query: 313 AKYDLEARQAMQEQLSKNKELTQKLQVASESEEEEGGTEDVEELLVPDVVNEVQMNADGP 372
E ++ QEQ K + +LQ EEE + EE D + Q
Sbjct: 722 RPRKQEGQRRRQEQEEKRRRRESELQW---QEEERAHRQQQEEEQRRDFTWQWQAEEKSE 778
Query: 373 NPWMLRSCTSDTKE-------AATQEDPEQ--LPELEAHGVSESEGEERPVAEEEILLRE 423
S +E A ++ EQ LPE E E +R E+E+ E
Sbjct: 779 RGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEE---KEQRRRQRREREKELQFLE 835
Query: 424 FEERRSLRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGT 483
EE+ R+R++ Q+ E ++ + SQE + + Q +E + R +
Sbjct: 836 EEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPAL 895
Query: 484 IPQVQREEPAPEEEEPLLLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQSERTPN 543
Q+++E+ +EEE L + + +E E +EE +E + + E ++ R
Sbjct: 896 QEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQE 955
Query: 544 NRPDAPKEKK---KKEQMIDLQNLLTTQSPSVKSLAVPTIEELEDEEERNHRQ 593
K+KK K+EQ++ + + K EEL+ EEE+ R+
Sbjct: 956 RERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREE--EELQQEEEQLLRE 1006
Score = 62.0 bits (149), Expect = 2e-09
Identities = 134/664 (20%), Positives = 261/664 (39%), Gaps = 97/664 (14%)
Query: 8 ESLLALSQQE--ELADLPKDYLLSESEDEGDNDGERKHQ--KLLEAISSLDGKNRRKLAE 63
E L L ++E E + + L E E+ + +R+ + +L + + S + + RR+ E
Sbjct: 486 ERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRS-EQQLRREQEE 544
Query: 64 RSEASLK-VSEFNVSSEGSGEKLVLADLLEPVKTSSSLATVKKQLSRVKSKKTVELPLNK 122
R E LK E + E ++L + ++Q + + ++ +E L +
Sbjct: 545 RREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKR 604
Query: 123 EEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVLSGWKART 182
EE+ER+ +E + Q L + +P + + +QL+ E+EE + R
Sbjct: 605 EEVERLEQE---ERREQRLKREEP---EEERRQQLLKSEEQEERRQQQLR--------RE 650
Query: 183 PLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAELQRARALQSYYEAKAR 242
E+ L + ++ + L + R L E + +A +R ++ ++ +
Sbjct: 651 QQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR-ERIKSRIPKWQWQLE 709
Query: 243 REKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERMSLKHQNS 302
E + K + +K + ++ +E E+ R+ + L+ E+ R + + +
Sbjct: 710 SEADARQSKVYSRPRKQEGQRRRQEQEEKRR-RRESELQWQEEERAHRQQQEEEQRRDFT 768
Query: 303 GKW-AKSKAIMAKYDLEARQAMQEQ-----------------LSKNKELTQKLQVASESE 344
+W A+ K+ + L AR ++EQ L + +E Q+ + E E
Sbjct: 769 WQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRERE 828
Query: 345 EEEGGTEDVEELLVPDVVNEVQMNADGPNP-----------------WML------RSCT 381
+E E+ E+L + ++Q DG W L R T
Sbjct: 829 KELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHT 888
Query: 382 SDTKEAAT----------QEDPEQLPELEAHGVSESEGEERPVAEEEILLREFEE----- 426
K A QE+ E+L E E +ER EEE L +E E+
Sbjct: 889 LYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQE-QERQYREEEQLQQEEEQLLREE 947
Query: 427 ---------RRSLRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQ---SR 474
R RK +L Q E +E + QE + R + +E Q
Sbjct: 948 REKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREE 1007
Query: 475 KQKASSEGTIPQVQREEPAPEEEEPLLLQRPERVQTLEELEELGKEECFQNKELPRPVLE 534
++K + Q ++++ +EEE LL + E+ + E + +EE Q +E L
Sbjct: 1008 REKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEE---EQLL 1064
Query: 535 GQQSERTPNNRPDAPKEKKKKEQMIDLQNLLTTQSPSVKSLAVPTIEELEDEE-ERNHRQ 593
G+ ER R + ++ +K+E++ + L + P + + E+EE ++ Q
Sbjct: 1065 GE--ERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQ 1122
Query: 594 MIKE 597
+++E
Sbjct: 1123 LLRE 1126
Score = 59.7 bits (143), Expect = 1e-08
Identities = 138/650 (21%), Positives = 252/650 (38%), Gaps = 105/650 (16%)
Query: 15 QQEELADLPKDYLLSESEDEGDNDGER---KHQKLLEAISSLDG----KNRRKLAE---R 64
++E+L + L E E + ER K +KL + L G K RR+ E R
Sbjct: 932 EEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYR 991
Query: 65 SEASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSSLATVKKQLSRVKSKKTVELPLNKEE 124
E L+ E + E EK + + L ++QL R + +K +E
Sbjct: 992 EEEELQQEEEQLLRE-EREKRRRQEWERQYRKKDELQQEEEQLLREEREKR-----RLQE 1045
Query: 125 IERIHREVAFNKTAQVLSKWDPVVL----KNRQAEQLVFPLEKEEPAIAPIEHVLSGWKA 180
ER +RE + L + + +L + R+ ++L KEE E +L
Sbjct: 1046 RERQYRE------EEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPE 1099
Query: 181 RTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAELQRARALQSYYEAK 240
+ ++ + + + L E+ R LE E+Q+ E +
Sbjct: 1100 KRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPE 1159
Query: 241 ARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERMSLKHQ 300
RR ++++ + + + + ++ L+E ++ R+ E E++++ + +R + Q
Sbjct: 1160 KRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQ 1219
Query: 301 NSG-KWAKSKAIMAKYDLEARQAMQEQ--LSKNKELTQKLQVASESEEEEGGTEDVEELL 357
S KW +++ E A+++ K +E Q Q+ + +D++ LL
Sbjct: 1220 RSDLKW--------QWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLL 1271
Query: 358 VPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGVSESEGEERPVAEE 417
+ + W R + PE+ +LE E++ +R EE
Sbjct: 1272 GEQQERDREQER---RRWQQRD----------RHFPEE-EQLEREEQKEAKRRDRKSQEE 1317
Query: 418 EILLREFEER--------RSLRKRSELSQDAE--PAGSQET-----------KDSGSQEV 456
+ LLRE E R R+ +L Q+ E P QE ++ G + +
Sbjct: 1318 KQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFL 1377
Query: 457 LSELRVLSQK-----LKENHQSRKQK-------------ASSEGTIPQVQREEPAPEEEE 498
E R+ Q+ LKE Q R Q+ E + + +R+ EEE+
Sbjct: 1378 EEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQ 1437
Query: 499 PLLLQRPERVQTLEELEELGKE--ECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKE 556
+ Q ER + LEE ++L +E F+ +E E QQ R +R +E++ +
Sbjct: 1438 QVRRQERER-KFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRR 1496
Query: 557 QMID---LQNLLTTQSPSVKSLAVPTIEELEDEEERNHRQMIKEAFAGDD 603
Q D + L +Q P K L +EE++ HRQ + F ++
Sbjct: 1497 QERDRKFREQELRSQEPERKFL---------EEEQQLHRQQRQRKFLQEE 1537
Score = 55.8 bits (133), Expect = 1e-07
Identities = 81/425 (19%), Positives = 168/425 (39%), Gaps = 71/425 (16%)
Query: 218 EEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKAL-KEFEQLRKVNP 276
+E ++RR EL R + + RRE++ + + + + K + L KE E+L++ P
Sbjct: 206 DEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEP 265
Query: 277 AAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQK 336
E E+ E+ R +ER L+ + + + Q++L + ++L +K
Sbjct: 266 QRQRELQEEEEQLRKLERQELRRER----------------QEEEQQQQRLRREQQLRRK 309
Query: 337 LQVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQL 396
Q E++E E E R + +E + + E+
Sbjct: 310 -QEEERREQQEERREQQER----------------------REQQEERREQQLRREQEER 346
Query: 397 PELEAHGVSESEGEERPVAEEEILLREFEERRSLRKRSELSQDAEPAGSQETKDS----- 451
E + E E E+ + E+ E + LR+ +L ++ + Q+ +
Sbjct: 347 REQQLRREQEEERREQQLRREQ---EEERREQQLRREQQLRREQQLRREQQLRREQQLRR 403
Query: 452 -----------GSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQ--------REEP 492
Q++ E ++ ++ +E H+ + ++ E + + Q REE
Sbjct: 404 EQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEE 463
Query: 493 APEEEEPLLLQRPERVQTLEELE---ELGKEECFQNKELPRPVLEGQQSERTPNNRPDAP 549
E+ Q+ +R Q E E +L +EE + +E L +Q ER R
Sbjct: 464 TERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERR-EQRLKRQ 522
Query: 550 KEKKKKEQMIDLQNLLTTQSPSVKSLAVPTIEELEDEEERNHRQMIKEAFAGDDVIRDFL 609
+E+++ +Q + + L + + + EE E+ER +++ +E D +
Sbjct: 523 EEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKRE 582
Query: 610 KEKRE 614
+E+R+
Sbjct: 583 EERRQ 587
Score = 55.5 bits (132), Expect = 2e-07
Identities = 81/405 (20%), Positives = 174/405 (42%), Gaps = 53/405 (13%)
Query: 218 EEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPA 277
EE ++ R + QR + LQ E + RR+++ + ++ + + +E EQLR+
Sbjct: 1520 EEQQLHRQQRQR-KFLQE--EQQLRRQERGQQRRQDR-------DRKFREEEQLRQEREE 1569
Query: 278 AALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKL 337
L E+ K R+ E+ + + K+ + + + + + + +Q QE+ K +E Q L
Sbjct: 1570 QQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQ-QQLRQERDRKFREDEQLL 1628
Query: 338 QVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQLP 397
Q E EE++ ++ + + + E Q+ + ++ +E+ + L
Sbjct: 1629 Q---EREEQQLHRQERDRKFLEE---EPQLRRQEREQQLRHD-----RDRKFREEEQLLQ 1677
Query: 398 ELEAHGVSESEGEERPVAEEEILLREFEERRSLRKRSELSQDAEPAGSQETKDSGSQEVL 457
E E + E + + EE+ L R+ ER+ L++ +L + QE+
Sbjct: 1678 EGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRR---------------QELE 1722
Query: 458 SELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLLQRPERVQTLEELEEL 517
+ R Q +E Q + ++ I + ++ P EE++ +R + + E+L +
Sbjct: 1723 RKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQE 1782
Query: 518 GKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMIDLQNLLTTQSPSVKSLAV 577
+E+ +++E R E +Q + + P+++ K + + Q L Q
Sbjct: 1783 REEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQE-------- 1834
Query: 578 PTIEELEDEEERNHRQMIKEAFAGDDVIRDFLKEKREAVEASKPK 622
+ L E +R +R +E FA + R +E++E + + K
Sbjct: 1835 ---QRLRQERDRQYR--AEEQFATQEKSR---REEQELWQEEEQK 1871
Score = 54.7 bits (130), Expect = 3e-07
Identities = 85/385 (22%), Positives = 163/385 (42%), Gaps = 50/385 (12%)
Query: 213 RAMSLEEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLR 272
R LEE K+RR E +R + ++ E + RR++ + + + K + ++ L+E E+ +
Sbjct: 1579 RKFRLEEQKVRRQEQER-KFMED--EQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQ 1635
Query: 273 KVNPAAALEELEKIEKARMMER-MSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNK 331
+ LE+ + R ER L+H K+ + + ++ + + E + QE+ K +
Sbjct: 1636 LHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGE-EQQLRRQERDRKFR 1694
Query: 332 ELTQKLQVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQE 391
E Q+L+ E E ++ ++L ++ + + + ++ +
Sbjct: 1695 EEEQQLR---RQERERKFLQEEQQLRRQELERKFR----------------EEEQLRQET 1735
Query: 392 DPEQLPELEAHGVSESEGEERPVAEEEILLREFEERRSLRKRSELSQDAEPAGSQETKDS 451
+ EQL E + E + RP EE+ L R+ E R R+ +L Q+ E Q+ +
Sbjct: 1736 EQEQLRRQERYRKILEEEQLRPEREEQQLRRQ-ERDRKFREEEQLRQERE---EQQLRSQ 1791
Query: 452 GSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLLQRPERVQTL 511
S E L Q+ +E Q R Q QR+ EEE L L+ E+
Sbjct: 1792 ESDRKFREEEQLRQE-REEQQLRPQ-----------QRDGKYRWEEEQLQLEEQEQRLRQ 1839
Query: 512 EELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMIDLQNLLTTQSPS 571
E + EE F +E R E Q+ + + +E+K +E+ I Q +
Sbjct: 1840 ERDRQYRAEEQFATQEKSR--REEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQ 1897
Query: 572 VKSLAVPTIEELEDEEERNHRQMIK 596
V E++ +E + H ++++
Sbjct: 1898 V--------GEIKSQEGKGHGRLLE 1914
Score = 53.1 bits (126), Expect = 9e-07
Identities = 85/391 (21%), Positives = 163/391 (41%), Gaps = 66/391 (16%)
Query: 218 EEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPA 277
EE ++ R E + A+ + K++ EK++ ++ + ++ + + +E EQL +
Sbjct: 1295 EEEQLEREEQKEAKRR----DRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREE 1350
Query: 278 AALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKL 337
L E+ K R E L+HQ G+ K+ LE Q ++ Q + K L ++
Sbjct: 1351 QPLRRQERDRKFREEE---LRHQEQGR---------KF-LEEEQRLRRQERERKFLKEEQ 1397
Query: 338 QVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQLP 397
Q+ + E++ ++ + D R + ++ + QE +
Sbjct: 1398 QLRCQEREQQ-----------------LRQDRD-------RKFREEEQQLSRQERDRKFR 1433
Query: 398 ELEAHGVSESEGEERPVAEEEILLREFEERRSLRKRSELSQDAEPAGSQETKDSGSQEVL 457
E E V E ER EEE LR+ E R R+ +L Q+ E Q + ++ L
Sbjct: 1434 E-EEQQVRRQE-RERKFLEEEQQLRQ-ERHRKFREEEQLLQEREE--QQLHRQERDRKFL 1488
Query: 458 SELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLLQRPERVQTLEELEEL 517
E Q+L+ + RK + E + + E EEE+ L Q+ +R + L+E ++L
Sbjct: 1489 EE----EQQLRRQERDRKFR---EQELRSQEPERKFLEEEQQLHRQQRQR-KFLQEEQQL 1540
Query: 518 GKEE-----------CFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMIDLQNLLT 566
++E F+ +E R E QQ R +R +E+K + Q + + +
Sbjct: 1541 RRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQE-RKFME 1599
Query: 567 TQSPSVKSLAVPTIEELEDEEERNHRQMIKE 597
+ + + + D + R Q+++E
Sbjct: 1600 DEQQLRRQEGQQQLRQERDRKFREDEQLLQE 1630
Score = 50.1 bits (118), Expect = 8e-06
Identities = 124/639 (19%), Positives = 251/639 (39%), Gaps = 101/639 (15%)
Query: 8 ESLLALSQQEELADLPKDYLLSESEDEGDNDGERKHQKLLEAISSLDGKNRRKLAERSEA 67
+ L L ++E+L + L E ED D ER+ S + + +K + E
Sbjct: 829 KELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRR--------SQEQRRDQKWRWQLEE 880
Query: 68 SLKVSEFNVSSEGSGEKLVLAD--LLEPVKTSSSLATVKKQLSRVKSKKTVELPLNKEEI 125
K + ++ + ++ + + LL+ + +K+ + + ++ E ++E
Sbjct: 881 ERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEE 940
Query: 126 ERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVLSGWKARTPLE 185
E++ RE + Q + + K+++ +Q L EEP + ++ L+
Sbjct: 941 EQLLREEREKRRRQ---ERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQ 997
Query: 186 QEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAELQRARALQSYYEAKARREK 245
QE LL + E+ R E ++ ELQ+ E + RE+
Sbjct: 998 QEEEQLLRE-------------EREKRRRQEWERQYRKKDELQQE-------EEQLLREE 1037
Query: 246 KIKSKKYHKVVKKGKAKKALKEFEQL----RKVNPAAALE-ELEKIEKARMMERMSLKHQ 300
+ K + + + + ++ +E EQL R+ LE + K E+ + E L+ +
Sbjct: 1038 REKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREE 1097
Query: 301 NSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESEEEEGGTEDVEELLVPD 360
+ + + + + E +Q ++ L + +E ++ ++ + EEE ++ E+LL +
Sbjct: 1098 PEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREE 1157
Query: 361 VVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGVSESEGEERPVAEEEIL 420
+ + +E Q++ EQL L + ER EEE L
Sbjct: 1158 PEKRRRQELE----------RQYREEEELQQEEEQL--LREEQEKRRQERERQYREEEEL 1205
Query: 421 LREFEER--RSLRKRSELSQDAEP-----------------------AGSQETKDSGSQE 455
R+ ++ R +RS+L EP + +D SQ+
Sbjct: 1206 QRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQ 1265
Query: 456 VLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLLQRPERVQTLEELE 515
L L + Q+ ++ Q R++ + P+ EE EE+ +R + Q ++L
Sbjct: 1266 DLQHL-LGEQQERDREQERRRWQQRDRHFPE---EEQLEREEQKEAKRRDRKSQEEKQLL 1321
Query: 516 ELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMIDLQNLLTTQSPSVKSL 575
+EE + +E R E +Q + +P +E+ +K + +L++ Q K L
Sbjct: 1322 REEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRH----QEQGRKFL 1377
Query: 576 AVPTIEELEDEEERNHRQMIKEAFAGDDVIRDFLKEKRE 614
EEE+ R+ +E R FLKE+++
Sbjct: 1378 ----------EEEQRLRRQERE--------RKFLKEEQQ 1398
Score = 48.9 bits (115), Expect = 2e-05
Identities = 79/409 (19%), Positives = 168/409 (41%), Gaps = 43/409 (10%)
Query: 213 RAMSLEEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLR 272
+A L+E K R + + + E RR + + + ++ + K+ +E E
Sbjct: 91 QATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAE 150
Query: 273 KVNPAAALEELEKIEKARMMERMSLKHQN----SGKWAKSKAIMAKYDLEARQAMQEQLS 328
+ E LE+ ++ R E + + Q + A+ + + + E + E+
Sbjct: 151 GEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQL 210
Query: 329 KNKELTQKLQVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAA 388
+ +EL + L+ E+++ E + + + E W R +E
Sbjct: 211 RRRELLE-LRRKGREEKQQQRRERQDRVFQEEEEKE----------WRKRETVLRKEEEK 259
Query: 389 TQED-PEQLPELEAHGVSESEGEERPVAEEEILLREFEERRSLRKRSELSQDAEPAGSQE 447
QE+ P++ EL + E E+ E + L RE +E ++R L ++ + QE
Sbjct: 260 LQEEEPQRQREL------QEEEEQLRKLERQELRRERQEEEQQQQR--LRREQQLRRKQE 311
Query: 448 TKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLLQRPE- 506
+ QE E + ++ +E + + ++ E Q++RE+ E+ L ++ E
Sbjct: 312 EERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEE 371
Query: 507 -RVQTLEELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMIDLQNLL 565
R Q L ++L +E+ + ++ R QQ R R + ++ ++EQ + + L
Sbjct: 372 RREQQLRREQQLRREQQLRREQQLR---REQQLRREQQLRRE---QQLRREQQLRREQQL 425
Query: 566 TTQSPSVKSLAVPTIEELEDEEERNHRQMIKEAFAGDDVIRDFLKEKRE 614
+ + E + E+ER +++ +E + RD+LK + E
Sbjct: 426 RREQEEER-------HEQKHEQERREQRLKRE----QEERRDWLKREEE 463
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 64.3 bits (155), Expect = 4e-10
Identities = 135/636 (21%), Positives = 261/636 (41%), Gaps = 63/636 (9%)
Query: 8 ESLLALSQQEEL-ADLPK-----DYLLSE---SEDEGDNDGERKHQKLLEAISSL----- 53
E+ A +++EL A+L K + LL+ +E+E + E+ Q+L
Sbjct: 1742 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1801
Query: 54 DGKNRRKLAERSEASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSSLATVKKQLSRVKSK 113
+ R LAE ++ +++E + + + + + VLA+ L + ++ L T + + K
Sbjct: 1802 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1861
Query: 114 KTVELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEH 173
+ L E+ E R + AQ + + + + R+A +K +E
Sbjct: 1862 ENERLRRLAED-EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-----GLVED 1915
Query: 174 VLSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMR-RAELQRARA 232
L + R +E+EI L ++ +E +R+ + + + + +AEL+ AR
Sbjct: 1916 TL---RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972
Query: 233 LQSYYEAKARR---EKKIKSKKYHKVVKKGKAKKALKEFEQLR-KVNPAAALEELEKIEK 288
Q E + RR E++++ + + K AL+E E+L+ KV A L E + E
Sbjct: 1973 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2032
Query: 289 ARMM---ERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESEE 345
AR + + + K + + A + A+ K Q +Q+ L + + + +L+ E+E
Sbjct: 2033 ARQLQLAQEAAQKRLQAEEKAHAFAVQQK-----EQELQQTLQQEQSVLDQLR--GEAEA 2085
Query: 346 EEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQED--PEQL-PELEAH 402
E+ EE V Q L+ + +A Q E+L E E
Sbjct: 2086 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2145
Query: 403 GVSESEGEERPVAEEEILLREFEERR-----SLRKRSELSQDAEPAGSQ-ETKDSGSQEV 456
++ E+ + +++ E E+ + +LR+++++ Q+ Q E D +
Sbjct: 2146 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2205
Query: 457 LSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPA------PEEEEPLLLQRPERVQT 510
EL+ L + E + R Q E +VQ EE + E L+L+ + Q
Sbjct: 2206 DEELQRLKAEATEAARQRSQ-VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264
Query: 511 -LEELEELGKEECFQNKELPRPVLEGQQ-----SERTPNNRPDAPKEKKKKEQMIDLQNL 564
L+E E K+ + L E + E R A K K+K Q +
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 565 LTTQSPSV---KSLAVPTIEELEDEEERNHRQMIKE 597
L ++ + K LA L++++E+ +Q+ +E
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2360
Score = 60.1 bits (144), Expect = 8e-09
Identities = 132/666 (19%), Positives = 269/666 (40%), Gaps = 93/666 (13%)
Query: 7 AESLLALSQQEELADLPKDYLLSESEDEGDNDGERKHQKLLEAISSLDGKNRRKLAERSE 66
AE L +Q EL + + L+ E+ + E + QK L A + + L E
Sbjct: 1955 AEDTLRSKEQAEL-EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013
Query: 67 ASLKVSEFNV----SSEGSGEKLVLAD-----LLEPVKTSSSLATVKKQ--LSRVKSKKT 115
KV E + + S +L LA L+ + + + A +K+ L + ++
Sbjct: 2014 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2073
Query: 116 VELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVL 175
L + E E R + A+V ++ + + + E EE A A +
Sbjct: 2074 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2133
Query: 176 SGWKARTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAELQRARALQS 235
+ K R EQE E+A+LR +A+M + + + L+
Sbjct: 2134 AAEKLRKEAEQEAARRAQ-------------AEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180
Query: 236 YYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERM 295
KA+ E+++ + + ++ + K L E Q K A + ++E+ R+
Sbjct: 2181 ----KAQVEQELTTLRL-QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2235
Query: 296 SLKHQNSGKW---AKSKAIMAKYDLEARQAMQEQLSKNKELTQ---KLQVASE------- 342
++ + K A+++A++ + ++ +QE+ K K++ + +L VA++
Sbjct: 2236 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2295
Query: 343 -SEEEEGGTEDVEELLVPDVVNEVQ----MNADGPNPWMLRSCTSDTKEAAT--QEDPEQ 395
+EE+ + E ++ + + VQ + A+ +L+ +E A QED EQ
Sbjct: 2296 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE---LLQQQKELAQEQARRLQEDKEQ 2352
Query: 396 LPEL---EAHGVSESEGEERP------VAEEEILLREFEERRSLRKRSELSQ----DAEP 442
+ + E G + ER E + LR E R+ + E +Q AE
Sbjct: 2353 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2412
Query: 443 AGSQ-ETKDSGSQEVLSELRVLS-QKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPL 500
G + + +QE ++ ++ L Q+ + +H + + + + I +++RE+ ++E L
Sbjct: 2413 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA----IAELEREKEKLQQEAKL 2468
Query: 501 LLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMID 560
L + E +QT+++ + L + + Q L + + +EK K EQ+
Sbjct: 2469 LQLKSEEMQTVQQEQLLQETQALQQSFL-------SEKDSLLQRERFIEQEKAKLEQLFQ 2521
Query: 561 LQNLLTTQSPSVKSLAVPTIEELEDEEERNHRQMIKEAFAGDDVIRDFLKEKREAVEASK 620
+ V ++L +E++R +QM +E + + + + EA E +
Sbjct: 2522 DE--------------VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2567
Query: 621 PKDVDL 626
K +L
Sbjct: 2568 RKQEEL 2573
Score = 53.5 bits (127), Expect = 7e-07
Identities = 130/678 (19%), Positives = 275/678 (40%), Gaps = 81/678 (11%)
Query: 5 RLAESLLALSQQEELADLPKDYLLSESEDEGDNDGERKHQKLLEAI-----SSLDGKNRR 59
RLAE AL +Q +LA+ ++++ + + + + Q++ E + +++D + ++
Sbjct: 1361 RLAEVEAALEKQRQLAEAH-----AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1415
Query: 60 K--------LAERSEASLKVSEFNVSSEGSGEKLVLADL------LEPVKTSSSLATVKK 105
+ L + SEA ++ + + ++ LE + A +
Sbjct: 1416 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1475
Query: 106 QLSRVKSKKT-VELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKE 164
Q R ++++ + +EE ER+ R+V + ++ V L +R + EK+
Sbjct: 1476 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE---VELASRVKAEAEAAREKQ 1532
Query: 165 EPAIAPIEHVLSGWKARTPLEQ-------EIFNLLHKNKQPVTDPLLTP----VEKASLR 213
A E L +A L Q ++ L ++ L + EK +
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1592
Query: 214 AMSLEEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRK 273
SL+E + A+L+ ++ +A+A R ++ ++ + + KA +AL+ Q +
Sbjct: 1593 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW--QLKANEALRLRLQAEE 1650
Query: 274 VNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAM-----QEQLS 328
V +L + E ++ ER + + + + A + +A+ +LE ++ + Q++L+
Sbjct: 1651 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1710
Query: 329 KNKELTQKLQVASESEEEEGGTEDVEELLV-------------PDVVNEVQMNADGPNPW 375
+EL +++ +E+E+ E + +EE L ++ E+
Sbjct: 1711 AEQEL---IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1767
Query: 376 MLRSCTSDTKEAATQEDPEQLPELEA---HGVSESEGEERPVAEEEILLREFEERRSLRK 432
+ ++ + +T E +Q E EA ++E R +AEE R+ E + R+
Sbjct: 1768 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1827
Query: 433 RSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEP 492
R+E AE +++ G L ++ K KE R ++ + + + + EE
Sbjct: 1828 RAE----AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQ 1883
Query: 493 APEE----EEPLLLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQS-ERTPNNRPD 547
A + EE L R LE + L ++ Q +++ +L + S E+ + +
Sbjct: 1884 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1943
Query: 548 APKEKKKKEQMIDLQNLLTTQSPSVKSLAVPTIEELEDEEERNHR---QMIKEAFAGDDV 604
E + + T +S L +L EEER R + ++++ A ++
Sbjct: 1944 LELELGRIRSNAE----DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999
Query: 605 IRDFLKEKREAVEASKPK 622
K E VE K K
Sbjct: 2000 AARQRKAALEEVERLKAK 2017
Score = 49.7 bits (117), Expect = 1e-05
Identities = 93/437 (21%), Positives = 170/437 (38%), Gaps = 48/437 (10%)
Query: 209 KASLRAMSLEEAKMRRAELQRARALQSYYEAKAR-REKKIKSKKYHKVVKKGKAKKALKE 267
KA L ++ AK + + +Q Y + + E + +Y K + + + ++E
Sbjct: 1290 KAQLEPVA-SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE--TLRRMEE 1346
Query: 268 FEQLRKVNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQL 327
E+L + A E L ++E A +R Q + A++KA + E +Q MQE++
Sbjct: 1347 EERLAEQQRAEERERLAEVEAALEKQR-----QLAEAHAQAKAQAEREAKELQQRMQEEV 1401
Query: 328 SKNKELT--------------QKLQVASESEEE----EGGTEDVEELLVPDVVNEVQMNA 369
+ +E Q+L+ +SE+E + + + L + + + V++
Sbjct: 1402 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1461
Query: 370 DGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGVSESEGEERPVAEEEILLREFEERRS 429
+ T + A E L L A E+E ++R EE LR + S
Sbjct: 1462 EA---------TERQRGGAEGE----LQALRARA-EEAEAQKRQAQEEAERLRRQVQDES 1507
Query: 430 LRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQR 489
RKR + A ++ Q L L L + +E + +Q QV
Sbjct: 1508 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1567
Query: 490 EEPAPEEEEPLLLQRPERVQTLEELEELGKEECFQNKELPRPV-LEGQQSERTPNNRPDA 548
E E L +R + +LE +EE +L QQ R +A
Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1627
Query: 549 PKEKKKKEQMIDLQNLLTTQSPSV---KSLAVPTIEELEDEEERNHRQMIK---EAFAGD 602
+E ++ + + L Q+ V KSLA E+ ++E ER R+ K +A
Sbjct: 1628 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1687
Query: 603 DVIRDFLKEKREAVEAS 619
++ L+++R+ E +
Sbjct: 1688 ELAEQELEKQRQLAEGT 1704
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 64.3 bits (155), Expect = 4e-10
Identities = 135/636 (21%), Positives = 261/636 (41%), Gaps = 63/636 (9%)
Query: 8 ESLLALSQQEEL-ADLPK-----DYLLSE---SEDEGDNDGERKHQKLLEAISSL----- 53
E+ A +++EL A+L K + LL+ +E+E + E+ Q+L
Sbjct: 1746 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1805
Query: 54 DGKNRRKLAERSEASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSSLATVKKQLSRVKSK 113
+ R LAE ++ +++E + + + + + VLA+ L + ++ L T + + K
Sbjct: 1806 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1865
Query: 114 KTVELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEH 173
+ L E+ E R + AQ + + + + R+A +K +E
Sbjct: 1866 ENERLRRLAED-EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-----GLVED 1919
Query: 174 VLSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMR-RAELQRARA 232
L + R +E+EI L ++ +E +R+ + + + + +AEL+ AR
Sbjct: 1920 TL---RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1976
Query: 233 LQSYYEAKARR---EKKIKSKKYHKVVKKGKAKKALKEFEQLR-KVNPAAALEELEKIEK 288
Q E + RR E++++ + + K AL+E E+L+ KV A L E + E
Sbjct: 1977 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2036
Query: 289 ARMM---ERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESEE 345
AR + + + K + + A + A+ K Q +Q+ L + + + +L+ E+E
Sbjct: 2037 ARQLQLAQEAAQKRLQAEEKAHAFAVQQK-----EQELQQTLQQEQSVLDQLR--GEAEA 2089
Query: 346 EEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQED--PEQL-PELEAH 402
E+ EE V Q L+ + +A Q E+L E E
Sbjct: 2090 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2149
Query: 403 GVSESEGEERPVAEEEILLREFEERR-----SLRKRSELSQDAEPAGSQ-ETKDSGSQEV 456
++ E+ + +++ E E+ + +LR+++++ Q+ Q E D +
Sbjct: 2150 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2209
Query: 457 LSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPA------PEEEEPLLLQRPERVQT 510
EL+ L + E + R Q E +VQ EE + E L+L+ + Q
Sbjct: 2210 DEELQRLKAEATEAARQRSQ-VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2268
Query: 511 -LEELEELGKEECFQNKELPRPVLEGQQ-----SERTPNNRPDAPKEKKKKEQMIDLQNL 564
L+E E K+ + L E + E R A K K+K Q +
Sbjct: 2269 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2328
Query: 565 LTTQSPSV---KSLAVPTIEELEDEEERNHRQMIKE 597
L ++ + K LA L++++E+ +Q+ +E
Sbjct: 2329 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2364
Score = 60.1 bits (144), Expect = 8e-09
Identities = 132/666 (19%), Positives = 269/666 (40%), Gaps = 93/666 (13%)
Query: 7 AESLLALSQQEELADLPKDYLLSESEDEGDNDGERKHQKLLEAISSLDGKNRRKLAERSE 66
AE L +Q EL + + L+ E+ + E + QK L A + + L E
Sbjct: 1959 AEDTLRSKEQAEL-EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2017
Query: 67 ASLKVSEFNV----SSEGSGEKLVLAD-----LLEPVKTSSSLATVKKQ--LSRVKSKKT 115
KV E + + S +L LA L+ + + + A +K+ L + ++
Sbjct: 2018 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2077
Query: 116 VELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVL 175
L + E E R + A+V ++ + + + E EE A A +
Sbjct: 2078 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2137
Query: 176 SGWKARTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAELQRARALQS 235
+ K R EQE E+A+LR +A+M + + + L+
Sbjct: 2138 AAEKLRKEAEQEAARRAQ-------------AEQAALRQKQAADAEMEKHKKFAEQTLRQ 2184
Query: 236 YYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERM 295
KA+ E+++ + + ++ + K L E Q K A + ++E+ R+
Sbjct: 2185 ----KAQVEQELTTLRL-QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2239
Query: 296 SLKHQNSGKW---AKSKAIMAKYDLEARQAMQEQLSKNKELTQ---KLQVASE------- 342
++ + K A+++A++ + ++ +QE+ K K++ + +L VA++
Sbjct: 2240 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2299
Query: 343 -SEEEEGGTEDVEELLVPDVVNEVQ----MNADGPNPWMLRSCTSDTKEAAT--QEDPEQ 395
+EE+ + E ++ + + VQ + A+ +L+ +E A QED EQ
Sbjct: 2300 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE---LLQQQKELAQEQARRLQEDKEQ 2356
Query: 396 LPEL---EAHGVSESEGEERP------VAEEEILLREFEERRSLRKRSELSQ----DAEP 442
+ + E G + ER E + LR E R+ + E +Q AE
Sbjct: 2357 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2416
Query: 443 AGSQ-ETKDSGSQEVLSELRVLS-QKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPL 500
G + + +QE ++ ++ L Q+ + +H + + + + I +++RE+ ++E L
Sbjct: 2417 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA----IAELEREKEKLQQEAKL 2472
Query: 501 LLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMID 560
L + E +QT+++ + L + + Q L + + +EK K EQ+
Sbjct: 2473 LQLKSEEMQTVQQEQLLQETQALQQSFL-------SEKDSLLQRERFIEQEKAKLEQLFQ 2525
Query: 561 LQNLLTTQSPSVKSLAVPTIEELEDEEERNHRQMIKEAFAGDDVIRDFLKEKREAVEASK 620
+ V ++L +E++R +QM +E + + + + EA E +
Sbjct: 2526 DE--------------VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2571
Query: 621 PKDVDL 626
K +L
Sbjct: 2572 RKQEEL 2577
Score = 53.5 bits (127), Expect = 7e-07
Identities = 130/678 (19%), Positives = 275/678 (40%), Gaps = 81/678 (11%)
Query: 5 RLAESLLALSQQEELADLPKDYLLSESEDEGDNDGERKHQKLLEAI-----SSLDGKNRR 59
RLAE AL +Q +LA+ ++++ + + + + Q++ E + +++D + ++
Sbjct: 1365 RLAEVEAALEKQRQLAEAH-----AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1419
Query: 60 K--------LAERSEASLKVSEFNVSSEGSGEKLVLADL------LEPVKTSSSLATVKK 105
+ L + SEA ++ + + ++ LE + A +
Sbjct: 1420 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1479
Query: 106 QLSRVKSKKT-VELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKE 164
Q R ++++ + +EE ER+ R+V + ++ V L +R + EK+
Sbjct: 1480 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE---VELASRVKAEAEAAREKQ 1536
Query: 165 EPAIAPIEHVLSGWKARTPLEQ-------EIFNLLHKNKQPVTDPLLTP----VEKASLR 213
A E L +A L Q ++ L ++ L + EK +
Sbjct: 1537 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1596
Query: 214 AMSLEEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRK 273
SL+E + A+L+ ++ +A+A R ++ ++ + + KA +AL+ Q +
Sbjct: 1597 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW--QLKANEALRLRLQAEE 1654
Query: 274 VNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAM-----QEQLS 328
V +L + E ++ ER + + + + A + +A+ +LE ++ + Q++L+
Sbjct: 1655 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1714
Query: 329 KNKELTQKLQVASESEEEEGGTEDVEELLV-------------PDVVNEVQMNADGPNPW 375
+EL +++ +E+E+ E + +EE L ++ E+
Sbjct: 1715 AEQEL---IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1771
Query: 376 MLRSCTSDTKEAATQEDPEQLPELEA---HGVSESEGEERPVAEEEILLREFEERRSLRK 432
+ ++ + +T E +Q E EA ++E R +AEE R+ E + R+
Sbjct: 1772 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1831
Query: 433 RSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEP 492
R+E AE +++ G L ++ K KE R ++ + + + + EE
Sbjct: 1832 RAE----AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQ 1887
Query: 493 APEE----EEPLLLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQS-ERTPNNRPD 547
A + EE L R LE + L ++ Q +++ +L + S E+ + +
Sbjct: 1888 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1947
Query: 548 APKEKKKKEQMIDLQNLLTTQSPSVKSLAVPTIEELEDEEERNHR---QMIKEAFAGDDV 604
E + + T +S L +L EEER R + ++++ A ++
Sbjct: 1948 LELELGRIRSNAE----DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2003
Query: 605 IRDFLKEKREAVEASKPK 622
K E VE K K
Sbjct: 2004 AARQRKAALEEVERLKAK 2021
Score = 49.7 bits (117), Expect = 1e-05
Identities = 93/437 (21%), Positives = 170/437 (38%), Gaps = 48/437 (10%)
Query: 209 KASLRAMSLEEAKMRRAELQRARALQSYYEAKAR-REKKIKSKKYHKVVKKGKAKKALKE 267
KA L ++ AK + + +Q Y + + E + +Y K + + + ++E
Sbjct: 1294 KAQLEPVA-SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE--TLRRMEE 1350
Query: 268 FEQLRKVNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQL 327
E+L + A E L ++E A +R Q + A++KA + E +Q MQE++
Sbjct: 1351 EERLAEQQRAEERERLAEVEAALEKQR-----QLAEAHAQAKAQAEREAKELQQRMQEEV 1405
Query: 328 SKNKELT--------------QKLQVASESEEE----EGGTEDVEELLVPDVVNEVQMNA 369
+ +E Q+L+ +SE+E + + + L + + + V++
Sbjct: 1406 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1465
Query: 370 DGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGVSESEGEERPVAEEEILLREFEERRS 429
+ T + A E L L A E+E ++R EE LR + S
Sbjct: 1466 EA---------TERQRGGAEGE----LQALRARA-EEAEAQKRQAQEEAERLRRQVQDES 1511
Query: 430 LRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQR 489
RKR + A ++ Q L L L + +E + +Q QV
Sbjct: 1512 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1571
Query: 490 EEPAPEEEEPLLLQRPERVQTLEELEELGKEECFQNKELPRPV-LEGQQSERTPNNRPDA 548
E E L +R + +LE +EE +L QQ R +A
Sbjct: 1572 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1631
Query: 549 PKEKKKKEQMIDLQNLLTTQSPSV---KSLAVPTIEELEDEEERNHRQMIK---EAFAGD 602
+E ++ + + L Q+ V KSLA E+ ++E ER R+ K +A
Sbjct: 1632 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1691
Query: 603 DVIRDFLKEKREAVEAS 619
++ L+++R+ E +
Sbjct: 1692 ELAEQELEKQRQLAEGT 1708
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 64.3 bits (155), Expect = 4e-10
Identities = 135/636 (21%), Positives = 261/636 (41%), Gaps = 63/636 (9%)
Query: 8 ESLLALSQQEEL-ADLPK-----DYLLSE---SEDEGDNDGERKHQKLLEAISSL----- 53
E+ A +++EL A+L K + LL+ +E+E + E+ Q+L
Sbjct: 1742 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1801
Query: 54 DGKNRRKLAERSEASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSSLATVKKQLSRVKSK 113
+ R LAE ++ +++E + + + + + VLA+ L + ++ L T + + K
Sbjct: 1802 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1861
Query: 114 KTVELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEH 173
+ L E+ E R + AQ + + + + R+A +K +E
Sbjct: 1862 ENERLRRLAED-EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-----GLVED 1915
Query: 174 VLSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMR-RAELQRARA 232
L + R +E+EI L ++ +E +R+ + + + + +AEL+ AR
Sbjct: 1916 TL---RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972
Query: 233 LQSYYEAKARR---EKKIKSKKYHKVVKKGKAKKALKEFEQLR-KVNPAAALEELEKIEK 288
Q E + RR E++++ + + K AL+E E+L+ KV A L E + E
Sbjct: 1973 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2032
Query: 289 ARMM---ERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESEE 345
AR + + + K + + A + A+ K Q +Q+ L + + + +L+ E+E
Sbjct: 2033 ARQLQLAQEAAQKRLQAEEKAHAFAVQQK-----EQELQQTLQQEQSVLDQLR--GEAEA 2085
Query: 346 EEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQED--PEQL-PELEAH 402
E+ EE V Q L+ + +A Q E+L E E
Sbjct: 2086 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2145
Query: 403 GVSESEGEERPVAEEEILLREFEERR-----SLRKRSELSQDAEPAGSQ-ETKDSGSQEV 456
++ E+ + +++ E E+ + +LR+++++ Q+ Q E D +
Sbjct: 2146 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2205
Query: 457 LSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPA------PEEEEPLLLQRPERVQT 510
EL+ L + E + R Q E +VQ EE + E L+L+ + Q
Sbjct: 2206 DEELQRLKAEATEAARQRSQ-VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264
Query: 511 -LEELEELGKEECFQNKELPRPVLEGQQ-----SERTPNNRPDAPKEKKKKEQMIDLQNL 564
L+E E K+ + L E + E R A K K+K Q +
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 565 LTTQSPSV---KSLAVPTIEELEDEEERNHRQMIKE 597
L ++ + K LA L++++E+ +Q+ +E
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2360
Score = 60.1 bits (144), Expect = 8e-09
Identities = 132/666 (19%), Positives = 269/666 (40%), Gaps = 93/666 (13%)
Query: 7 AESLLALSQQEELADLPKDYLLSESEDEGDNDGERKHQKLLEAISSLDGKNRRKLAERSE 66
AE L +Q EL + + L+ E+ + E + QK L A + + L E
Sbjct: 1955 AEDTLRSKEQAEL-EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013
Query: 67 ASLKVSEFNV----SSEGSGEKLVLAD-----LLEPVKTSSSLATVKKQ--LSRVKSKKT 115
KV E + + S +L LA L+ + + + A +K+ L + ++
Sbjct: 2014 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2073
Query: 116 VELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVL 175
L + E E R + A+V ++ + + + E EE A A +
Sbjct: 2074 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2133
Query: 176 SGWKARTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAELQRARALQS 235
+ K R EQE E+A+LR +A+M + + + L+
Sbjct: 2134 AAEKLRKEAEQEAARRAQ-------------AEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180
Query: 236 YYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERM 295
KA+ E+++ + + ++ + K L E Q K A + ++E+ R+
Sbjct: 2181 ----KAQVEQELTTLRL-QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2235
Query: 296 SLKHQNSGKW---AKSKAIMAKYDLEARQAMQEQLSKNKELTQ---KLQVASE------- 342
++ + K A+++A++ + ++ +QE+ K K++ + +L VA++
Sbjct: 2236 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2295
Query: 343 -SEEEEGGTEDVEELLVPDVVNEVQ----MNADGPNPWMLRSCTSDTKEAAT--QEDPEQ 395
+EE+ + E ++ + + VQ + A+ +L+ +E A QED EQ
Sbjct: 2296 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE---LLQQQKELAQEQARRLQEDKEQ 2352
Query: 396 LPEL---EAHGVSESEGEERP------VAEEEILLREFEERRSLRKRSELSQ----DAEP 442
+ + E G + ER E + LR E R+ + E +Q AE
Sbjct: 2353 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2412
Query: 443 AGSQ-ETKDSGSQEVLSELRVLS-QKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPL 500
G + + +QE ++ ++ L Q+ + +H + + + + I +++RE+ ++E L
Sbjct: 2413 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA----IAELEREKEKLQQEAKL 2468
Query: 501 LLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMID 560
L + E +QT+++ + L + + Q L + + +EK K EQ+
Sbjct: 2469 LQLKSEEMQTVQQEQLLQETQALQQSFL-------SEKDSLLQRERFIEQEKAKLEQLFQ 2521
Query: 561 LQNLLTTQSPSVKSLAVPTIEELEDEEERNHRQMIKEAFAGDDVIRDFLKEKREAVEASK 620
+ V ++L +E++R +QM +E + + + + EA E +
Sbjct: 2522 DE--------------VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2567
Query: 621 PKDVDL 626
K +L
Sbjct: 2568 RKQEEL 2573
Score = 53.5 bits (127), Expect = 7e-07
Identities = 130/678 (19%), Positives = 275/678 (40%), Gaps = 81/678 (11%)
Query: 5 RLAESLLALSQQEELADLPKDYLLSESEDEGDNDGERKHQKLLEAI-----SSLDGKNRR 59
RLAE AL +Q +LA+ ++++ + + + + Q++ E + +++D + ++
Sbjct: 1361 RLAEVEAALEKQRQLAEAH-----AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1415
Query: 60 K--------LAERSEASLKVSEFNVSSEGSGEKLVLADL------LEPVKTSSSLATVKK 105
+ L + SEA ++ + + ++ LE + A +
Sbjct: 1416 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1475
Query: 106 QLSRVKSKKT-VELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKE 164
Q R ++++ + +EE ER+ R+V + ++ V L +R + EK+
Sbjct: 1476 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE---VELASRVKAEAEAAREKQ 1532
Query: 165 EPAIAPIEHVLSGWKARTPLEQ-------EIFNLLHKNKQPVTDPLLTP----VEKASLR 213
A E L +A L Q ++ L ++ L + EK +
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1592
Query: 214 AMSLEEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRK 273
SL+E + A+L+ ++ +A+A R ++ ++ + + KA +AL+ Q +
Sbjct: 1593 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW--QLKANEALRLRLQAEE 1650
Query: 274 VNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAM-----QEQLS 328
V +L + E ++ ER + + + + A + +A+ +LE ++ + Q++L+
Sbjct: 1651 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1710
Query: 329 KNKELTQKLQVASESEEEEGGTEDVEELLV-------------PDVVNEVQMNADGPNPW 375
+EL +++ +E+E+ E + +EE L ++ E+
Sbjct: 1711 AEQEL---IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1767
Query: 376 MLRSCTSDTKEAATQEDPEQLPELEA---HGVSESEGEERPVAEEEILLREFEERRSLRK 432
+ ++ + +T E +Q E EA ++E R +AEE R+ E + R+
Sbjct: 1768 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1827
Query: 433 RSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEP 492
R+E AE +++ G L ++ K KE R ++ + + + + EE
Sbjct: 1828 RAE----AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQ 1883
Query: 493 APEE----EEPLLLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQS-ERTPNNRPD 547
A + EE L R LE + L ++ Q +++ +L + S E+ + +
Sbjct: 1884 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1943
Query: 548 APKEKKKKEQMIDLQNLLTTQSPSVKSLAVPTIEELEDEEERNHR---QMIKEAFAGDDV 604
E + + T +S L +L EEER R + ++++ A ++
Sbjct: 1944 LELELGRIRSNAE----DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999
Query: 605 IRDFLKEKREAVEASKPK 622
K E VE K K
Sbjct: 2000 AARQRKAALEEVERLKAK 2017
Score = 49.7 bits (117), Expect = 1e-05
Identities = 93/437 (21%), Positives = 170/437 (38%), Gaps = 48/437 (10%)
Query: 209 KASLRAMSLEEAKMRRAELQRARALQSYYEAKAR-REKKIKSKKYHKVVKKGKAKKALKE 267
KA L ++ AK + + +Q Y + + E + +Y K + + + ++E
Sbjct: 1290 KAQLEPVA-SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE--TLRRMEE 1346
Query: 268 FEQLRKVNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQL 327
E+L + A E L ++E A +R Q + A++KA + E +Q MQE++
Sbjct: 1347 EERLAEQQRAEERERLAEVEAALEKQR-----QLAEAHAQAKAQAEREAKELQQRMQEEV 1401
Query: 328 SKNKELT--------------QKLQVASESEEE----EGGTEDVEELLVPDVVNEVQMNA 369
+ +E Q+L+ +SE+E + + + L + + + V++
Sbjct: 1402 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1461
Query: 370 DGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGVSESEGEERPVAEEEILLREFEERRS 429
+ T + A E L L A E+E ++R EE LR + S
Sbjct: 1462 EA---------TERQRGGAEGE----LQALRARA-EEAEAQKRQAQEEAERLRRQVQDES 1507
Query: 430 LRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQR 489
RKR + A ++ Q L L L + +E + +Q QV
Sbjct: 1508 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1567
Query: 490 EEPAPEEEEPLLLQRPERVQTLEELEELGKEECFQNKELPRPV-LEGQQSERTPNNRPDA 548
E E L +R + +LE +EE +L QQ R +A
Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1627
Query: 549 PKEKKKKEQMIDLQNLLTTQSPSV---KSLAVPTIEELEDEEERNHRQMIK---EAFAGD 602
+E ++ + + L Q+ V KSLA E+ ++E ER R+ K +A
Sbjct: 1628 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1687
Query: 603 DVIRDFLKEKREAVEAS 619
++ L+++R+ E +
Sbjct: 1688 ELAEQELEKQRQLAEGT 1704
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 64.3 bits (155), Expect = 4e-10
Identities = 135/636 (21%), Positives = 261/636 (41%), Gaps = 63/636 (9%)
Query: 8 ESLLALSQQEEL-ADLPK-----DYLLSE---SEDEGDNDGERKHQKLLEAISSL----- 53
E+ A +++EL A+L K + LL+ +E+E + E+ Q+L
Sbjct: 1710 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1769
Query: 54 DGKNRRKLAERSEASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSSLATVKKQLSRVKSK 113
+ R LAE ++ +++E + + + + + VLA+ L + ++ L T + + K
Sbjct: 1770 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1829
Query: 114 KTVELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEH 173
+ L E+ E R + AQ + + + + R+A +K +E
Sbjct: 1830 ENERLRRLAED-EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-----GLVED 1883
Query: 174 VLSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMR-RAELQRARA 232
L + R +E+EI L ++ +E +R+ + + + + +AEL+ AR
Sbjct: 1884 TL---RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1940
Query: 233 LQSYYEAKARR---EKKIKSKKYHKVVKKGKAKKALKEFEQLR-KVNPAAALEELEKIEK 288
Q E + RR E++++ + + K AL+E E+L+ KV A L E + E
Sbjct: 1941 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2000
Query: 289 ARMM---ERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESEE 345
AR + + + K + + A + A+ K Q +Q+ L + + + +L+ E+E
Sbjct: 2001 ARQLQLAQEAAQKRLQAEEKAHAFAVQQK-----EQELQQTLQQEQSVLDQLR--GEAEA 2053
Query: 346 EEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQED--PEQL-PELEAH 402
E+ EE V Q L+ + +A Q E+L E E
Sbjct: 2054 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2113
Query: 403 GVSESEGEERPVAEEEILLREFEERR-----SLRKRSELSQDAEPAGSQ-ETKDSGSQEV 456
++ E+ + +++ E E+ + +LR+++++ Q+ Q E D +
Sbjct: 2114 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2173
Query: 457 LSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPA------PEEEEPLLLQRPERVQT 510
EL+ L + E + R Q E +VQ EE + E L+L+ + Q
Sbjct: 2174 DEELQRLKAEATEAARQRSQ-VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2232
Query: 511 -LEELEELGKEECFQNKELPRPVLEGQQ-----SERTPNNRPDAPKEKKKKEQMIDLQNL 564
L+E E K+ + L E + E R A K K+K Q +
Sbjct: 2233 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2292
Query: 565 LTTQSPSV---KSLAVPTIEELEDEEERNHRQMIKE 597
L ++ + K LA L++++E+ +Q+ +E
Sbjct: 2293 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2328
Score = 60.1 bits (144), Expect = 8e-09
Identities = 132/666 (19%), Positives = 269/666 (40%), Gaps = 93/666 (13%)
Query: 7 AESLLALSQQEELADLPKDYLLSESEDEGDNDGERKHQKLLEAISSLDGKNRRKLAERSE 66
AE L +Q EL + + L+ E+ + E + QK L A + + L E
Sbjct: 1923 AEDTLRSKEQAEL-EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1981
Query: 67 ASLKVSEFNV----SSEGSGEKLVLAD-----LLEPVKTSSSLATVKKQ--LSRVKSKKT 115
KV E + + S +L LA L+ + + + A +K+ L + ++
Sbjct: 1982 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2041
Query: 116 VELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVL 175
L + E E R + A+V ++ + + + E EE A A +
Sbjct: 2042 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2101
Query: 176 SGWKARTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAELQRARALQS 235
+ K R EQE E+A+LR +A+M + + + L+
Sbjct: 2102 AAEKLRKEAEQEAARRAQ-------------AEQAALRQKQAADAEMEKHKKFAEQTLRQ 2148
Query: 236 YYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERM 295
KA+ E+++ + + ++ + K L E Q K A + ++E+ R+
Sbjct: 2149 ----KAQVEQELTTLRL-QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2203
Query: 296 SLKHQNSGKW---AKSKAIMAKYDLEARQAMQEQLSKNKELTQ---KLQVASE------- 342
++ + K A+++A++ + ++ +QE+ K K++ + +L VA++
Sbjct: 2204 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2263
Query: 343 -SEEEEGGTEDVEELLVPDVVNEVQ----MNADGPNPWMLRSCTSDTKEAAT--QEDPEQ 395
+EE+ + E ++ + + VQ + A+ +L+ +E A QED EQ
Sbjct: 2264 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE---LLQQQKELAQEQARRLQEDKEQ 2320
Query: 396 LPEL---EAHGVSESEGEERP------VAEEEILLREFEERRSLRKRSELSQ----DAEP 442
+ + E G + ER E + LR E R+ + E +Q AE
Sbjct: 2321 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2380
Query: 443 AGSQ-ETKDSGSQEVLSELRVLS-QKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPL 500
G + + +QE ++ ++ L Q+ + +H + + + + I +++RE+ ++E L
Sbjct: 2381 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA----IAELEREKEKLQQEAKL 2436
Query: 501 LLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMID 560
L + E +QT+++ + L + + Q L + + +EK K EQ+
Sbjct: 2437 LQLKSEEMQTVQQEQLLQETQALQQSFL-------SEKDSLLQRERFIEQEKAKLEQLFQ 2489
Query: 561 LQNLLTTQSPSVKSLAVPTIEELEDEEERNHRQMIKEAFAGDDVIRDFLKEKREAVEASK 620
+ V ++L +E++R +QM +E + + + + EA E +
Sbjct: 2490 DE--------------VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2535
Query: 621 PKDVDL 626
K +L
Sbjct: 2536 RKQEEL 2541
Score = 53.5 bits (127), Expect = 7e-07
Identities = 130/678 (19%), Positives = 275/678 (40%), Gaps = 81/678 (11%)
Query: 5 RLAESLLALSQQEELADLPKDYLLSESEDEGDNDGERKHQKLLEAI-----SSLDGKNRR 59
RLAE AL +Q +LA+ ++++ + + + + Q++ E + +++D + ++
Sbjct: 1329 RLAEVEAALEKQRQLAEAH-----AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1383
Query: 60 K--------LAERSEASLKVSEFNVSSEGSGEKLVLADL------LEPVKTSSSLATVKK 105
+ L + SEA ++ + + ++ LE + A +
Sbjct: 1384 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1443
Query: 106 QLSRVKSKKT-VELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKE 164
Q R ++++ + +EE ER+ R+V + ++ V L +R + EK+
Sbjct: 1444 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE---VELASRVKAEAEAAREKQ 1500
Query: 165 EPAIAPIEHVLSGWKARTPLEQ-------EIFNLLHKNKQPVTDPLLTP----VEKASLR 213
A E L +A L Q ++ L ++ L + EK +
Sbjct: 1501 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1560
Query: 214 AMSLEEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRK 273
SL+E + A+L+ ++ +A+A R ++ ++ + + KA +AL+ Q +
Sbjct: 1561 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW--QLKANEALRLRLQAEE 1618
Query: 274 VNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAM-----QEQLS 328
V +L + E ++ ER + + + + A + +A+ +LE ++ + Q++L+
Sbjct: 1619 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1678
Query: 329 KNKELTQKLQVASESEEEEGGTEDVEELLV-------------PDVVNEVQMNADGPNPW 375
+EL +++ +E+E+ E + +EE L ++ E+
Sbjct: 1679 AEQEL---IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1735
Query: 376 MLRSCTSDTKEAATQEDPEQLPELEA---HGVSESEGEERPVAEEEILLREFEERRSLRK 432
+ ++ + +T E +Q E EA ++E R +AEE R+ E + R+
Sbjct: 1736 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1795
Query: 433 RSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEP 492
R+E AE +++ G L ++ K KE R ++ + + + + EE
Sbjct: 1796 RAE----AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQ 1851
Query: 493 APEE----EEPLLLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQS-ERTPNNRPD 547
A + EE L R LE + L ++ Q +++ +L + S E+ + +
Sbjct: 1852 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1911
Query: 548 APKEKKKKEQMIDLQNLLTTQSPSVKSLAVPTIEELEDEEERNHR---QMIKEAFAGDDV 604
E + + T +S L +L EEER R + ++++ A ++
Sbjct: 1912 LELELGRIRSNAE----DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1967
Query: 605 IRDFLKEKREAVEASKPK 622
K E VE K K
Sbjct: 1968 AARQRKAALEEVERLKAK 1985
Score = 49.7 bits (117), Expect = 1e-05
Identities = 93/437 (21%), Positives = 170/437 (38%), Gaps = 48/437 (10%)
Query: 209 KASLRAMSLEEAKMRRAELQRARALQSYYEAKAR-REKKIKSKKYHKVVKKGKAKKALKE 267
KA L ++ AK + + +Q Y + + E + +Y K + + + ++E
Sbjct: 1258 KAQLEPVA-SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE--TLRRMEE 1314
Query: 268 FEQLRKVNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQL 327
E+L + A E L ++E A +R Q + A++KA + E +Q MQE++
Sbjct: 1315 EERLAEQQRAEERERLAEVEAALEKQR-----QLAEAHAQAKAQAEREAKELQQRMQEEV 1369
Query: 328 SKNKELT--------------QKLQVASESEEE----EGGTEDVEELLVPDVVNEVQMNA 369
+ +E Q+L+ +SE+E + + + L + + + V++
Sbjct: 1370 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1429
Query: 370 DGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGVSESEGEERPVAEEEILLREFEERRS 429
+ T + A E L L A E+E ++R EE LR + S
Sbjct: 1430 EA---------TERQRGGAEGE----LQALRARA-EEAEAQKRQAQEEAERLRRQVQDES 1475
Query: 430 LRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQR 489
RKR + A ++ Q L L L + +E + +Q QV
Sbjct: 1476 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1535
Query: 490 EEPAPEEEEPLLLQRPERVQTLEELEELGKEECFQNKELPRPV-LEGQQSERTPNNRPDA 548
E E L +R + +LE +EE +L QQ R +A
Sbjct: 1536 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1595
Query: 549 PKEKKKKEQMIDLQNLLTTQSPSV---KSLAVPTIEELEDEEERNHRQMIK---EAFAGD 602
+E ++ + + L Q+ V KSLA E+ ++E ER R+ K +A
Sbjct: 1596 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1655
Query: 603 DVIRDFLKEKREAVEAS 619
++ L+++R+ E +
Sbjct: 1656 ELAEQELEKQRQLAEGT 1672
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 64.3 bits (155), Expect = 4e-10
Identities = 135/636 (21%), Positives = 261/636 (41%), Gaps = 63/636 (9%)
Query: 8 ESLLALSQQEEL-ADLPK-----DYLLSE---SEDEGDNDGERKHQKLLEAISSL----- 53
E+ A +++EL A+L K + LL+ +E+E + E+ Q+L
Sbjct: 1879 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1938
Query: 54 DGKNRRKLAERSEASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSSLATVKKQLSRVKSK 113
+ R LAE ++ +++E + + + + + VLA+ L + ++ L T + + K
Sbjct: 1939 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1998
Query: 114 KTVELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEH 173
+ L E+ E R + AQ + + + + R+A +K +E
Sbjct: 1999 ENERLRRLAED-EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-----GLVED 2052
Query: 174 VLSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMR-RAELQRARA 232
L + R +E+EI L ++ +E +R+ + + + + +AEL+ AR
Sbjct: 2053 TL---RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 2109
Query: 233 LQSYYEAKARR---EKKIKSKKYHKVVKKGKAKKALKEFEQLR-KVNPAAALEELEKIEK 288
Q E + RR E++++ + + K AL+E E+L+ KV A L E + E
Sbjct: 2110 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2169
Query: 289 ARMM---ERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESEE 345
AR + + + K + + A + A+ K Q +Q+ L + + + +L+ E+E
Sbjct: 2170 ARQLQLAQEAAQKRLQAEEKAHAFAVQQK-----EQELQQTLQQEQSVLDQLR--GEAEA 2222
Query: 346 EEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQED--PEQL-PELEAH 402
E+ EE V Q L+ + +A Q E+L E E
Sbjct: 2223 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2282
Query: 403 GVSESEGEERPVAEEEILLREFEERR-----SLRKRSELSQDAEPAGSQ-ETKDSGSQEV 456
++ E+ + +++ E E+ + +LR+++++ Q+ Q E D +
Sbjct: 2283 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2342
Query: 457 LSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPA------PEEEEPLLLQRPERVQT 510
EL+ L + E + R Q E +VQ EE + E L+L+ + Q
Sbjct: 2343 DEELQRLKAEATEAARQRSQ-VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2401
Query: 511 -LEELEELGKEECFQNKELPRPVLEGQQ-----SERTPNNRPDAPKEKKKKEQMIDLQNL 564
L+E E K+ + L E + E R A K K+K Q +
Sbjct: 2402 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2461
Query: 565 LTTQSPSV---KSLAVPTIEELEDEEERNHRQMIKE 597
L ++ + K LA L++++E+ +Q+ +E
Sbjct: 2462 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2497
Score = 60.1 bits (144), Expect = 8e-09
Identities = 132/666 (19%), Positives = 269/666 (40%), Gaps = 93/666 (13%)
Query: 7 AESLLALSQQEELADLPKDYLLSESEDEGDNDGERKHQKLLEAISSLDGKNRRKLAERSE 66
AE L +Q EL + + L+ E+ + E + QK L A + + L E
Sbjct: 2092 AEDTLRSKEQAEL-EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2150
Query: 67 ASLKVSEFNV----SSEGSGEKLVLAD-----LLEPVKTSSSLATVKKQ--LSRVKSKKT 115
KV E + + S +L LA L+ + + + A +K+ L + ++
Sbjct: 2151 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2210
Query: 116 VELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVL 175
L + E E R + A+V ++ + + + E EE A A +
Sbjct: 2211 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2270
Query: 176 SGWKARTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAELQRARALQS 235
+ K R EQE E+A+LR +A+M + + + L+
Sbjct: 2271 AAEKLRKEAEQEAARRAQ-------------AEQAALRQKQAADAEMEKHKKFAEQTLRQ 2317
Query: 236 YYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERM 295
KA+ E+++ + + ++ + K L E Q K A + ++E+ R+
Sbjct: 2318 ----KAQVEQELTTLRL-QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2372
Query: 296 SLKHQNSGKW---AKSKAIMAKYDLEARQAMQEQLSKNKELTQ---KLQVASE------- 342
++ + K A+++A++ + ++ +QE+ K K++ + +L VA++
Sbjct: 2373 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2432
Query: 343 -SEEEEGGTEDVEELLVPDVVNEVQ----MNADGPNPWMLRSCTSDTKEAAT--QEDPEQ 395
+EE+ + E ++ + + VQ + A+ +L+ +E A QED EQ
Sbjct: 2433 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE---LLQQQKELAQEQARRLQEDKEQ 2489
Query: 396 LPEL---EAHGVSESEGEERP------VAEEEILLREFEERRSLRKRSELSQ----DAEP 442
+ + E G + ER E + LR E R+ + E +Q AE
Sbjct: 2490 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2549
Query: 443 AGSQ-ETKDSGSQEVLSELRVLS-QKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPL 500
G + + +QE ++ ++ L Q+ + +H + + + + I +++RE+ ++E L
Sbjct: 2550 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA----IAELEREKEKLQQEAKL 2605
Query: 501 LLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMID 560
L + E +QT+++ + L + + Q L + + +EK K EQ+
Sbjct: 2606 LQLKSEEMQTVQQEQLLQETQALQQSFL-------SEKDSLLQRERFIEQEKAKLEQLFQ 2658
Query: 561 LQNLLTTQSPSVKSLAVPTIEELEDEEERNHRQMIKEAFAGDDVIRDFLKEKREAVEASK 620
+ V ++L +E++R +QM +E + + + + EA E +
Sbjct: 2659 DE--------------VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2704
Query: 621 PKDVDL 626
K +L
Sbjct: 2705 RKQEEL 2710
Score = 53.5 bits (127), Expect = 7e-07
Identities = 130/678 (19%), Positives = 275/678 (40%), Gaps = 81/678 (11%)
Query: 5 RLAESLLALSQQEELADLPKDYLLSESEDEGDNDGERKHQKLLEAI-----SSLDGKNRR 59
RLAE AL +Q +LA+ ++++ + + + + Q++ E + +++D + ++
Sbjct: 1498 RLAEVEAALEKQRQLAEAH-----AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1552
Query: 60 K--------LAERSEASLKVSEFNVSSEGSGEKLVLADL------LEPVKTSSSLATVKK 105
+ L + SEA ++ + + ++ LE + A +
Sbjct: 1553 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1612
Query: 106 QLSRVKSKKT-VELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKE 164
Q R ++++ + +EE ER+ R+V + ++ V L +R + EK+
Sbjct: 1613 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE---VELASRVKAEAEAAREKQ 1669
Query: 165 EPAIAPIEHVLSGWKARTPLEQ-------EIFNLLHKNKQPVTDPLLTP----VEKASLR 213
A E L +A L Q ++ L ++ L + EK +
Sbjct: 1670 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1729
Query: 214 AMSLEEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRK 273
SL+E + A+L+ ++ +A+A R ++ ++ + + KA +AL+ Q +
Sbjct: 1730 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW--QLKANEALRLRLQAEE 1787
Query: 274 VNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAM-----QEQLS 328
V +L + E ++ ER + + + + A + +A+ +LE ++ + Q++L+
Sbjct: 1788 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1847
Query: 329 KNKELTQKLQVASESEEEEGGTEDVEELLV-------------PDVVNEVQMNADGPNPW 375
+EL +++ +E+E+ E + +EE L ++ E+
Sbjct: 1848 AEQEL---IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1904
Query: 376 MLRSCTSDTKEAATQEDPEQLPELEA---HGVSESEGEERPVAEEEILLREFEERRSLRK 432
+ ++ + +T E +Q E EA ++E R +AEE R+ E + R+
Sbjct: 1905 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1964
Query: 433 RSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEP 492
R+E AE +++ G L ++ K KE R ++ + + + + EE
Sbjct: 1965 RAE----AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQ 2020
Query: 493 APEE----EEPLLLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQS-ERTPNNRPD 547
A + EE L R LE + L ++ Q +++ +L + S E+ + +
Sbjct: 2021 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 2080
Query: 548 APKEKKKKEQMIDLQNLLTTQSPSVKSLAVPTIEELEDEEERNHR---QMIKEAFAGDDV 604
E + + T +S L +L EEER R + ++++ A ++
Sbjct: 2081 LELELGRIRSNAE----DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2136
Query: 605 IRDFLKEKREAVEASKPK 622
K E VE K K
Sbjct: 2137 AARQRKAALEEVERLKAK 2154
Score = 49.7 bits (117), Expect = 1e-05
Identities = 93/437 (21%), Positives = 170/437 (38%), Gaps = 48/437 (10%)
Query: 209 KASLRAMSLEEAKMRRAELQRARALQSYYEAKAR-REKKIKSKKYHKVVKKGKAKKALKE 267
KA L ++ AK + + +Q Y + + E + +Y K + + + ++E
Sbjct: 1427 KAQLEPVA-SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE--TLRRMEE 1483
Query: 268 FEQLRKVNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQL 327
E+L + A E L ++E A +R Q + A++KA + E +Q MQE++
Sbjct: 1484 EERLAEQQRAEERERLAEVEAALEKQR-----QLAEAHAQAKAQAEREAKELQQRMQEEV 1538
Query: 328 SKNKELT--------------QKLQVASESEEE----EGGTEDVEELLVPDVVNEVQMNA 369
+ +E Q+L+ +SE+E + + + L + + + V++
Sbjct: 1539 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1598
Query: 370 DGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGVSESEGEERPVAEEEILLREFEERRS 429
+ T + A E L L A E+E ++R EE LR + S
Sbjct: 1599 EA---------TERQRGGAEGE----LQALRARA-EEAEAQKRQAQEEAERLRRQVQDES 1644
Query: 430 LRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQR 489
RKR + A ++ Q L L L + +E + +Q QV
Sbjct: 1645 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1704
Query: 490 EEPAPEEEEPLLLQRPERVQTLEELEELGKEECFQNKELPRPV-LEGQQSERTPNNRPDA 548
E E L +R + +LE +EE +L QQ R +A
Sbjct: 1705 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1764
Query: 549 PKEKKKKEQMIDLQNLLTTQSPSV---KSLAVPTIEELEDEEERNHRQMIK---EAFAGD 602
+E ++ + + L Q+ V KSLA E+ ++E ER R+ K +A
Sbjct: 1765 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1824
Query: 603 DVIRDFLKEKREAVEAS 619
++ L+++R+ E +
Sbjct: 1825 ELAEQELEKQRQLAEGT 1841
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 64.3 bits (155), Expect = 4e-10
Identities = 135/636 (21%), Positives = 261/636 (41%), Gaps = 63/636 (9%)
Query: 8 ESLLALSQQEEL-ADLPK-----DYLLSE---SEDEGDNDGERKHQKLLEAISSL----- 53
E+ A +++EL A+L K + LL+ +E+E + E+ Q+L
Sbjct: 1720 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1779
Query: 54 DGKNRRKLAERSEASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSSLATVKKQLSRVKSK 113
+ R LAE ++ +++E + + + + + VLA+ L + ++ L T + + K
Sbjct: 1780 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1839
Query: 114 KTVELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEH 173
+ L E+ E R + AQ + + + + R+A +K +E
Sbjct: 1840 ENERLRRLAED-EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-----GLVED 1893
Query: 174 VLSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMR-RAELQRARA 232
L + R +E+EI L ++ +E +R+ + + + + +AEL+ AR
Sbjct: 1894 TL---RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1950
Query: 233 LQSYYEAKARR---EKKIKSKKYHKVVKKGKAKKALKEFEQLR-KVNPAAALEELEKIEK 288
Q E + RR E++++ + + K AL+E E+L+ KV A L E + E
Sbjct: 1951 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2010
Query: 289 ARMM---ERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESEE 345
AR + + + K + + A + A+ K Q +Q+ L + + + +L+ E+E
Sbjct: 2011 ARQLQLAQEAAQKRLQAEEKAHAFAVQQK-----EQELQQTLQQEQSVLDQLR--GEAEA 2063
Query: 346 EEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQED--PEQL-PELEAH 402
E+ EE V Q L+ + +A Q E+L E E
Sbjct: 2064 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2123
Query: 403 GVSESEGEERPVAEEEILLREFEERR-----SLRKRSELSQDAEPAGSQ-ETKDSGSQEV 456
++ E+ + +++ E E+ + +LR+++++ Q+ Q E D +
Sbjct: 2124 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2183
Query: 457 LSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPA------PEEEEPLLLQRPERVQT 510
EL+ L + E + R Q E +VQ EE + E L+L+ + Q
Sbjct: 2184 DEELQRLKAEATEAARQRSQ-VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2242
Query: 511 -LEELEELGKEECFQNKELPRPVLEGQQ-----SERTPNNRPDAPKEKKKKEQMIDLQNL 564
L+E E K+ + L E + E R A K K+K Q +
Sbjct: 2243 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2302
Query: 565 LTTQSPSV---KSLAVPTIEELEDEEERNHRQMIKE 597
L ++ + K LA L++++E+ +Q+ +E
Sbjct: 2303 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2338
Score = 60.1 bits (144), Expect = 8e-09
Identities = 132/666 (19%), Positives = 269/666 (40%), Gaps = 93/666 (13%)
Query: 7 AESLLALSQQEELADLPKDYLLSESEDEGDNDGERKHQKLLEAISSLDGKNRRKLAERSE 66
AE L +Q EL + + L+ E+ + E + QK L A + + L E
Sbjct: 1933 AEDTLRSKEQAEL-EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1991
Query: 67 ASLKVSEFNV----SSEGSGEKLVLAD-----LLEPVKTSSSLATVKKQ--LSRVKSKKT 115
KV E + + S +L LA L+ + + + A +K+ L + ++
Sbjct: 1992 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2051
Query: 116 VELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVL 175
L + E E R + A+V ++ + + + E EE A A +
Sbjct: 2052 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2111
Query: 176 SGWKARTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAELQRARALQS 235
+ K R EQE E+A+LR +A+M + + + L+
Sbjct: 2112 AAEKLRKEAEQEAARRAQ-------------AEQAALRQKQAADAEMEKHKKFAEQTLRQ 2158
Query: 236 YYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERM 295
KA+ E+++ + + ++ + K L E Q K A + ++E+ R+
Sbjct: 2159 ----KAQVEQELTTLRL-QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2213
Query: 296 SLKHQNSGKW---AKSKAIMAKYDLEARQAMQEQLSKNKELTQ---KLQVASE------- 342
++ + K A+++A++ + ++ +QE+ K K++ + +L VA++
Sbjct: 2214 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2273
Query: 343 -SEEEEGGTEDVEELLVPDVVNEVQ----MNADGPNPWMLRSCTSDTKEAAT--QEDPEQ 395
+EE+ + E ++ + + VQ + A+ +L+ +E A QED EQ
Sbjct: 2274 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE---LLQQQKELAQEQARRLQEDKEQ 2330
Query: 396 LPEL---EAHGVSESEGEERP------VAEEEILLREFEERRSLRKRSELSQ----DAEP 442
+ + E G + ER E + LR E R+ + E +Q AE
Sbjct: 2331 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2390
Query: 443 AGSQ-ETKDSGSQEVLSELRVLS-QKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPL 500
G + + +QE ++ ++ L Q+ + +H + + + + I +++RE+ ++E L
Sbjct: 2391 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA----IAELEREKEKLQQEAKL 2446
Query: 501 LLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMID 560
L + E +QT+++ + L + + Q L + + +EK K EQ+
Sbjct: 2447 LQLKSEEMQTVQQEQLLQETQALQQSFL-------SEKDSLLQRERFIEQEKAKLEQLFQ 2499
Query: 561 LQNLLTTQSPSVKSLAVPTIEELEDEEERNHRQMIKEAFAGDDVIRDFLKEKREAVEASK 620
+ V ++L +E++R +QM +E + + + + EA E +
Sbjct: 2500 DE--------------VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2545
Query: 621 PKDVDL 626
K +L
Sbjct: 2546 RKQEEL 2551
Score = 53.5 bits (127), Expect = 7e-07
Identities = 130/678 (19%), Positives = 275/678 (40%), Gaps = 81/678 (11%)
Query: 5 RLAESLLALSQQEELADLPKDYLLSESEDEGDNDGERKHQKLLEAI-----SSLDGKNRR 59
RLAE AL +Q +LA+ ++++ + + + + Q++ E + +++D + ++
Sbjct: 1339 RLAEVEAALEKQRQLAEAH-----AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1393
Query: 60 K--------LAERSEASLKVSEFNVSSEGSGEKLVLADL------LEPVKTSSSLATVKK 105
+ L + SEA ++ + + ++ LE + A +
Sbjct: 1394 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1453
Query: 106 QLSRVKSKKT-VELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKE 164
Q R ++++ + +EE ER+ R+V + ++ V L +R + EK+
Sbjct: 1454 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE---VELASRVKAEAEAAREKQ 1510
Query: 165 EPAIAPIEHVLSGWKARTPLEQ-------EIFNLLHKNKQPVTDPLLTP----VEKASLR 213
A E L +A L Q ++ L ++ L + EK +
Sbjct: 1511 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1570
Query: 214 AMSLEEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRK 273
SL+E + A+L+ ++ +A+A R ++ ++ + + KA +AL+ Q +
Sbjct: 1571 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW--QLKANEALRLRLQAEE 1628
Query: 274 VNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAM-----QEQLS 328
V +L + E ++ ER + + + + A + +A+ +LE ++ + Q++L+
Sbjct: 1629 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1688
Query: 329 KNKELTQKLQVASESEEEEGGTEDVEELLV-------------PDVVNEVQMNADGPNPW 375
+EL +++ +E+E+ E + +EE L ++ E+
Sbjct: 1689 AEQEL---IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1745
Query: 376 MLRSCTSDTKEAATQEDPEQLPELEA---HGVSESEGEERPVAEEEILLREFEERRSLRK 432
+ ++ + +T E +Q E EA ++E R +AEE R+ E + R+
Sbjct: 1746 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1805
Query: 433 RSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEP 492
R+E AE +++ G L ++ K KE R ++ + + + + EE
Sbjct: 1806 RAE----AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQ 1861
Query: 493 APEE----EEPLLLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQS-ERTPNNRPD 547
A + EE L R LE + L ++ Q +++ +L + S E+ + +
Sbjct: 1862 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1921
Query: 548 APKEKKKKEQMIDLQNLLTTQSPSVKSLAVPTIEELEDEEERNHR---QMIKEAFAGDDV 604
E + + T +S L +L EEER R + ++++ A ++
Sbjct: 1922 LELELGRIRSNAE----DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1977
Query: 605 IRDFLKEKREAVEASKPK 622
K E VE K K
Sbjct: 1978 AARQRKAALEEVERLKAK 1995
Score = 49.7 bits (117), Expect = 1e-05
Identities = 93/437 (21%), Positives = 170/437 (38%), Gaps = 48/437 (10%)
Query: 209 KASLRAMSLEEAKMRRAELQRARALQSYYEAKAR-REKKIKSKKYHKVVKKGKAKKALKE 267
KA L ++ AK + + +Q Y + + E + +Y K + + + ++E
Sbjct: 1268 KAQLEPVA-SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE--TLRRMEE 1324
Query: 268 FEQLRKVNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQL 327
E+L + A E L ++E A +R Q + A++KA + E +Q MQE++
Sbjct: 1325 EERLAEQQRAEERERLAEVEAALEKQR-----QLAEAHAQAKAQAEREAKELQQRMQEEV 1379
Query: 328 SKNKELT--------------QKLQVASESEEE----EGGTEDVEELLVPDVVNEVQMNA 369
+ +E Q+L+ +SE+E + + + L + + + V++
Sbjct: 1380 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1439
Query: 370 DGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGVSESEGEERPVAEEEILLREFEERRS 429
+ T + A E L L A E+E ++R EE LR + S
Sbjct: 1440 EA---------TERQRGGAEGE----LQALRARA-EEAEAQKRQAQEEAERLRRQVQDES 1485
Query: 430 LRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQR 489
RKR + A ++ Q L L L + +E + +Q QV
Sbjct: 1486 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1545
Query: 490 EEPAPEEEEPLLLQRPERVQTLEELEELGKEECFQNKELPRPV-LEGQQSERTPNNRPDA 548
E E L +R + +LE +EE +L QQ R +A
Sbjct: 1546 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1605
Query: 549 PKEKKKKEQMIDLQNLLTTQSPSV---KSLAVPTIEELEDEEERNHRQMIK---EAFAGD 602
+E ++ + + L Q+ V KSLA E+ ++E ER R+ K +A
Sbjct: 1606 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1665
Query: 603 DVIRDFLKEKREAVEAS 619
++ L+++R+ E +
Sbjct: 1666 ELAEQELEKQRQLAEGT 1682
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 64.3 bits (155), Expect = 4e-10
Identities = 135/636 (21%), Positives = 261/636 (41%), Gaps = 63/636 (9%)
Query: 8 ESLLALSQQEEL-ADLPK-----DYLLSE---SEDEGDNDGERKHQKLLEAISSL----- 53
E+ A +++EL A+L K + LL+ +E+E + E+ Q+L
Sbjct: 1728 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1787
Query: 54 DGKNRRKLAERSEASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSSLATVKKQLSRVKSK 113
+ R LAE ++ +++E + + + + + VLA+ L + ++ L T + + K
Sbjct: 1788 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1847
Query: 114 KTVELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEH 173
+ L E+ E R + AQ + + + + R+A +K +E
Sbjct: 1848 ENERLRRLAED-EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-----GLVED 1901
Query: 174 VLSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMR-RAELQRARA 232
L + R +E+EI L ++ +E +R+ + + + + +AEL+ AR
Sbjct: 1902 TL---RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1958
Query: 233 LQSYYEAKARR---EKKIKSKKYHKVVKKGKAKKALKEFEQLR-KVNPAAALEELEKIEK 288
Q E + RR E++++ + + K AL+E E+L+ KV A L E + E
Sbjct: 1959 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2018
Query: 289 ARMM---ERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESEE 345
AR + + + K + + A + A+ K Q +Q+ L + + + +L+ E+E
Sbjct: 2019 ARQLQLAQEAAQKRLQAEEKAHAFAVQQK-----EQELQQTLQQEQSVLDQLR--GEAEA 2071
Query: 346 EEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQED--PEQL-PELEAH 402
E+ EE V Q L+ + +A Q E+L E E
Sbjct: 2072 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2131
Query: 403 GVSESEGEERPVAEEEILLREFEERR-----SLRKRSELSQDAEPAGSQ-ETKDSGSQEV 456
++ E+ + +++ E E+ + +LR+++++ Q+ Q E D +
Sbjct: 2132 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2191
Query: 457 LSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPA------PEEEEPLLLQRPERVQT 510
EL+ L + E + R Q E +VQ EE + E L+L+ + Q
Sbjct: 2192 DEELQRLKAEATEAARQRSQ-VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2250
Query: 511 -LEELEELGKEECFQNKELPRPVLEGQQ-----SERTPNNRPDAPKEKKKKEQMIDLQNL 564
L+E E K+ + L E + E R A K K+K Q +
Sbjct: 2251 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2310
Query: 565 LTTQSPSV---KSLAVPTIEELEDEEERNHRQMIKE 597
L ++ + K LA L++++E+ +Q+ +E
Sbjct: 2311 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2346
Score = 60.1 bits (144), Expect = 8e-09
Identities = 132/666 (19%), Positives = 269/666 (40%), Gaps = 93/666 (13%)
Query: 7 AESLLALSQQEELADLPKDYLLSESEDEGDNDGERKHQKLLEAISSLDGKNRRKLAERSE 66
AE L +Q EL + + L+ E+ + E + QK L A + + L E
Sbjct: 1941 AEDTLRSKEQAEL-EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1999
Query: 67 ASLKVSEFNV----SSEGSGEKLVLAD-----LLEPVKTSSSLATVKKQ--LSRVKSKKT 115
KV E + + S +L LA L+ + + + A +K+ L + ++
Sbjct: 2000 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2059
Query: 116 VELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVL 175
L + E E R + A+V ++ + + + E EE A A +
Sbjct: 2060 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2119
Query: 176 SGWKARTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAELQRARALQS 235
+ K R EQE E+A+LR +A+M + + + L+
Sbjct: 2120 AAEKLRKEAEQEAARRAQ-------------AEQAALRQKQAADAEMEKHKKFAEQTLRQ 2166
Query: 236 YYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERM 295
KA+ E+++ + + ++ + K L E Q K A + ++E+ R+
Sbjct: 2167 ----KAQVEQELTTLRL-QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2221
Query: 296 SLKHQNSGKW---AKSKAIMAKYDLEARQAMQEQLSKNKELTQ---KLQVASE------- 342
++ + K A+++A++ + ++ +QE+ K K++ + +L VA++
Sbjct: 2222 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2281
Query: 343 -SEEEEGGTEDVEELLVPDVVNEVQ----MNADGPNPWMLRSCTSDTKEAAT--QEDPEQ 395
+EE+ + E ++ + + VQ + A+ +L+ +E A QED EQ
Sbjct: 2282 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE---LLQQQKELAQEQARRLQEDKEQ 2338
Query: 396 LPEL---EAHGVSESEGEERP------VAEEEILLREFEERRSLRKRSELSQ----DAEP 442
+ + E G + ER E + LR E R+ + E +Q AE
Sbjct: 2339 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2398
Query: 443 AGSQ-ETKDSGSQEVLSELRVLS-QKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPL 500
G + + +QE ++ ++ L Q+ + +H + + + + I +++RE+ ++E L
Sbjct: 2399 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA----IAELEREKEKLQQEAKL 2454
Query: 501 LLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMID 560
L + E +QT+++ + L + + Q L + + +EK K EQ+
Sbjct: 2455 LQLKSEEMQTVQQEQLLQETQALQQSFL-------SEKDSLLQRERFIEQEKAKLEQLFQ 2507
Query: 561 LQNLLTTQSPSVKSLAVPTIEELEDEEERNHRQMIKEAFAGDDVIRDFLKEKREAVEASK 620
+ V ++L +E++R +QM +E + + + + EA E +
Sbjct: 2508 DE--------------VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2553
Query: 621 PKDVDL 626
K +L
Sbjct: 2554 RKQEEL 2559
Score = 53.5 bits (127), Expect = 7e-07
Identities = 130/678 (19%), Positives = 275/678 (40%), Gaps = 81/678 (11%)
Query: 5 RLAESLLALSQQEELADLPKDYLLSESEDEGDNDGERKHQKLLEAI-----SSLDGKNRR 59
RLAE AL +Q +LA+ ++++ + + + + Q++ E + +++D + ++
Sbjct: 1347 RLAEVEAALEKQRQLAEAH-----AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1401
Query: 60 K--------LAERSEASLKVSEFNVSSEGSGEKLVLADL------LEPVKTSSSLATVKK 105
+ L + SEA ++ + + ++ LE + A +
Sbjct: 1402 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1461
Query: 106 QLSRVKSKKT-VELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKE 164
Q R ++++ + +EE ER+ R+V + ++ V L +R + EK+
Sbjct: 1462 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE---VELASRVKAEAEAAREKQ 1518
Query: 165 EPAIAPIEHVLSGWKARTPLEQ-------EIFNLLHKNKQPVTDPLLTP----VEKASLR 213
A E L +A L Q ++ L ++ L + EK +
Sbjct: 1519 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1578
Query: 214 AMSLEEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRK 273
SL+E + A+L+ ++ +A+A R ++ ++ + + KA +AL+ Q +
Sbjct: 1579 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW--QLKANEALRLRLQAEE 1636
Query: 274 VNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAM-----QEQLS 328
V +L + E ++ ER + + + + A + +A+ +LE ++ + Q++L+
Sbjct: 1637 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1696
Query: 329 KNKELTQKLQVASESEEEEGGTEDVEELLV-------------PDVVNEVQMNADGPNPW 375
+EL +++ +E+E+ E + +EE L ++ E+
Sbjct: 1697 AEQEL---IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1753
Query: 376 MLRSCTSDTKEAATQEDPEQLPELEA---HGVSESEGEERPVAEEEILLREFEERRSLRK 432
+ ++ + +T E +Q E EA ++E R +AEE R+ E + R+
Sbjct: 1754 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1813
Query: 433 RSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEP 492
R+E AE +++ G L ++ K KE R ++ + + + + EE
Sbjct: 1814 RAE----AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQ 1869
Query: 493 APEE----EEPLLLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQS-ERTPNNRPD 547
A + EE L R LE + L ++ Q +++ +L + S E+ + +
Sbjct: 1870 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1929
Query: 548 APKEKKKKEQMIDLQNLLTTQSPSVKSLAVPTIEELEDEEERNHR---QMIKEAFAGDDV 604
E + + T +S L +L EEER R + ++++ A ++
Sbjct: 1930 LELELGRIRSNAE----DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1985
Query: 605 IRDFLKEKREAVEASKPK 622
K E VE K K
Sbjct: 1986 AARQRKAALEEVERLKAK 2003
Score = 49.7 bits (117), Expect = 1e-05
Identities = 93/437 (21%), Positives = 170/437 (38%), Gaps = 48/437 (10%)
Query: 209 KASLRAMSLEEAKMRRAELQRARALQSYYEAKAR-REKKIKSKKYHKVVKKGKAKKALKE 267
KA L ++ AK + + +Q Y + + E + +Y K + + + ++E
Sbjct: 1276 KAQLEPVA-SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE--TLRRMEE 1332
Query: 268 FEQLRKVNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQL 327
E+L + A E L ++E A +R Q + A++KA + E +Q MQE++
Sbjct: 1333 EERLAEQQRAEERERLAEVEAALEKQR-----QLAEAHAQAKAQAEREAKELQQRMQEEV 1387
Query: 328 SKNKELT--------------QKLQVASESEEE----EGGTEDVEELLVPDVVNEVQMNA 369
+ +E Q+L+ +SE+E + + + L + + + V++
Sbjct: 1388 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1447
Query: 370 DGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGVSESEGEERPVAEEEILLREFEERRS 429
+ T + A E L L A E+E ++R EE LR + S
Sbjct: 1448 EA---------TERQRGGAEGE----LQALRARA-EEAEAQKRQAQEEAERLRRQVQDES 1493
Query: 430 LRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQR 489
RKR + A ++ Q L L L + +E + +Q QV
Sbjct: 1494 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1553
Query: 490 EEPAPEEEEPLLLQRPERVQTLEELEELGKEECFQNKELPRPV-LEGQQSERTPNNRPDA 548
E E L +R + +LE +EE +L QQ R +A
Sbjct: 1554 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1613
Query: 549 PKEKKKKEQMIDLQNLLTTQSPSV---KSLAVPTIEELEDEEERNHRQMIK---EAFAGD 602
+E ++ + + L Q+ V KSLA E+ ++E ER R+ K +A
Sbjct: 1614 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1673
Query: 603 DVIRDFLKEKREAVEAS 619
++ L+++R+ E +
Sbjct: 1674 ELAEQELEKQRQLAEGT 1690
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 64.3 bits (155), Expect = 4e-10
Identities = 135/636 (21%), Positives = 261/636 (41%), Gaps = 63/636 (9%)
Query: 8 ESLLALSQQEEL-ADLPK-----DYLLSE---SEDEGDNDGERKHQKLLEAISSL----- 53
E+ A +++EL A+L K + LL+ +E+E + E+ Q+L
Sbjct: 1769 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1828
Query: 54 DGKNRRKLAERSEASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSSLATVKKQLSRVKSK 113
+ R LAE ++ +++E + + + + + VLA+ L + ++ L T + + K
Sbjct: 1829 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1888
Query: 114 KTVELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEH 173
+ L E+ E R + AQ + + + + R+A +K +E
Sbjct: 1889 ENERLRRLAED-EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-----GLVED 1942
Query: 174 VLSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMR-RAELQRARA 232
L + R +E+EI L ++ +E +R+ + + + + +AEL+ AR
Sbjct: 1943 TL---RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1999
Query: 233 LQSYYEAKARR---EKKIKSKKYHKVVKKGKAKKALKEFEQLR-KVNPAAALEELEKIEK 288
Q E + RR E++++ + + K AL+E E+L+ KV A L E + E
Sbjct: 2000 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2059
Query: 289 ARMM---ERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESEE 345
AR + + + K + + A + A+ K Q +Q+ L + + + +L+ E+E
Sbjct: 2060 ARQLQLAQEAAQKRLQAEEKAHAFAVQQK-----EQELQQTLQQEQSVLDQLR--GEAEA 2112
Query: 346 EEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQED--PEQL-PELEAH 402
E+ EE V Q L+ + +A Q E+L E E
Sbjct: 2113 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2172
Query: 403 GVSESEGEERPVAEEEILLREFEERR-----SLRKRSELSQDAEPAGSQ-ETKDSGSQEV 456
++ E+ + +++ E E+ + +LR+++++ Q+ Q E D +
Sbjct: 2173 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2232
Query: 457 LSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPA------PEEEEPLLLQRPERVQT 510
EL+ L + E + R Q E +VQ EE + E L+L+ + Q
Sbjct: 2233 DEELQRLKAEATEAARQRSQ-VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2291
Query: 511 -LEELEELGKEECFQNKELPRPVLEGQQ-----SERTPNNRPDAPKEKKKKEQMIDLQNL 564
L+E E K+ + L E + E R A K K+K Q +
Sbjct: 2292 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2351
Query: 565 LTTQSPSV---KSLAVPTIEELEDEEERNHRQMIKE 597
L ++ + K LA L++++E+ +Q+ +E
Sbjct: 2352 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2387
Score = 60.1 bits (144), Expect = 8e-09
Identities = 132/666 (19%), Positives = 269/666 (40%), Gaps = 93/666 (13%)
Query: 7 AESLLALSQQEELADLPKDYLLSESEDEGDNDGERKHQKLLEAISSLDGKNRRKLAERSE 66
AE L +Q EL + + L+ E+ + E + QK L A + + L E
Sbjct: 1982 AEDTLRSKEQAEL-EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2040
Query: 67 ASLKVSEFNV----SSEGSGEKLVLAD-----LLEPVKTSSSLATVKKQ--LSRVKSKKT 115
KV E + + S +L LA L+ + + + A +K+ L + ++
Sbjct: 2041 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2100
Query: 116 VELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVL 175
L + E E R + A+V ++ + + + E EE A A +
Sbjct: 2101 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2160
Query: 176 SGWKARTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAELQRARALQS 235
+ K R EQE E+A+LR +A+M + + + L+
Sbjct: 2161 AAEKLRKEAEQEAARRAQ-------------AEQAALRQKQAADAEMEKHKKFAEQTLRQ 2207
Query: 236 YYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERM 295
KA+ E+++ + + ++ + K L E Q K A + ++E+ R+
Sbjct: 2208 ----KAQVEQELTTLRL-QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2262
Query: 296 SLKHQNSGKW---AKSKAIMAKYDLEARQAMQEQLSKNKELTQ---KLQVASE------- 342
++ + K A+++A++ + ++ +QE+ K K++ + +L VA++
Sbjct: 2263 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2322
Query: 343 -SEEEEGGTEDVEELLVPDVVNEVQ----MNADGPNPWMLRSCTSDTKEAAT--QEDPEQ 395
+EE+ + E ++ + + VQ + A+ +L+ +E A QED EQ
Sbjct: 2323 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE---LLQQQKELAQEQARRLQEDKEQ 2379
Query: 396 LPEL---EAHGVSESEGEERP------VAEEEILLREFEERRSLRKRSELSQ----DAEP 442
+ + E G + ER E + LR E R+ + E +Q AE
Sbjct: 2380 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2439
Query: 443 AGSQ-ETKDSGSQEVLSELRVLS-QKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPL 500
G + + +QE ++ ++ L Q+ + +H + + + + I +++RE+ ++E L
Sbjct: 2440 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA----IAELEREKEKLQQEAKL 2495
Query: 501 LLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMID 560
L + E +QT+++ + L + + Q L + + +EK K EQ+
Sbjct: 2496 LQLKSEEMQTVQQEQLLQETQALQQSFL-------SEKDSLLQRERFIEQEKAKLEQLFQ 2548
Query: 561 LQNLLTTQSPSVKSLAVPTIEELEDEEERNHRQMIKEAFAGDDVIRDFLKEKREAVEASK 620
+ V ++L +E++R +QM +E + + + + EA E +
Sbjct: 2549 DE--------------VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2594
Query: 621 PKDVDL 626
K +L
Sbjct: 2595 RKQEEL 2600
Score = 53.5 bits (127), Expect = 7e-07
Identities = 130/678 (19%), Positives = 275/678 (40%), Gaps = 81/678 (11%)
Query: 5 RLAESLLALSQQEELADLPKDYLLSESEDEGDNDGERKHQKLLEAI-----SSLDGKNRR 59
RLAE AL +Q +LA+ ++++ + + + + Q++ E + +++D + ++
Sbjct: 1388 RLAEVEAALEKQRQLAEAH-----AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1442
Query: 60 K--------LAERSEASLKVSEFNVSSEGSGEKLVLADL------LEPVKTSSSLATVKK 105
+ L + SEA ++ + + ++ LE + A +
Sbjct: 1443 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1502
Query: 106 QLSRVKSKKT-VELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKE 164
Q R ++++ + +EE ER+ R+V + ++ V L +R + EK+
Sbjct: 1503 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE---VELASRVKAEAEAAREKQ 1559
Query: 165 EPAIAPIEHVLSGWKARTPLEQ-------EIFNLLHKNKQPVTDPLLTP----VEKASLR 213
A E L +A L Q ++ L ++ L + EK +
Sbjct: 1560 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1619
Query: 214 AMSLEEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRK 273
SL+E + A+L+ ++ +A+A R ++ ++ + + KA +AL+ Q +
Sbjct: 1620 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW--QLKANEALRLRLQAEE 1677
Query: 274 VNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAM-----QEQLS 328
V +L + E ++ ER + + + + A + +A+ +LE ++ + Q++L+
Sbjct: 1678 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1737
Query: 329 KNKELTQKLQVASESEEEEGGTEDVEELLV-------------PDVVNEVQMNADGPNPW 375
+EL +++ +E+E+ E + +EE L ++ E+
Sbjct: 1738 AEQEL---IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1794
Query: 376 MLRSCTSDTKEAATQEDPEQLPELEA---HGVSESEGEERPVAEEEILLREFEERRSLRK 432
+ ++ + +T E +Q E EA ++E R +AEE R+ E + R+
Sbjct: 1795 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1854
Query: 433 RSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEP 492
R+E AE +++ G L ++ K KE R ++ + + + + EE
Sbjct: 1855 RAE----AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQ 1910
Query: 493 APEE----EEPLLLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQS-ERTPNNRPD 547
A + EE L R LE + L ++ Q +++ +L + S E+ + +
Sbjct: 1911 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1970
Query: 548 APKEKKKKEQMIDLQNLLTTQSPSVKSLAVPTIEELEDEEERNHR---QMIKEAFAGDDV 604
E + + T +S L +L EEER R + ++++ A ++
Sbjct: 1971 LELELGRIRSNAE----DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2026
Query: 605 IRDFLKEKREAVEASKPK 622
K E VE K K
Sbjct: 2027 AARQRKAALEEVERLKAK 2044
Score = 49.7 bits (117), Expect = 1e-05
Identities = 93/437 (21%), Positives = 170/437 (38%), Gaps = 48/437 (10%)
Query: 209 KASLRAMSLEEAKMRRAELQRARALQSYYEAKAR-REKKIKSKKYHKVVKKGKAKKALKE 267
KA L ++ AK + + +Q Y + + E + +Y K + + + ++E
Sbjct: 1317 KAQLEPVA-SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE--TLRRMEE 1373
Query: 268 FEQLRKVNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQL 327
E+L + A E L ++E A +R Q + A++KA + E +Q MQE++
Sbjct: 1374 EERLAEQQRAEERERLAEVEAALEKQR-----QLAEAHAQAKAQAEREAKELQQRMQEEV 1428
Query: 328 SKNKELT--------------QKLQVASESEEE----EGGTEDVEELLVPDVVNEVQMNA 369
+ +E Q+L+ +SE+E + + + L + + + V++
Sbjct: 1429 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1488
Query: 370 DGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGVSESEGEERPVAEEEILLREFEERRS 429
+ T + A E L L A E+E ++R EE LR + S
Sbjct: 1489 EA---------TERQRGGAEGE----LQALRARA-EEAEAQKRQAQEEAERLRRQVQDES 1534
Query: 430 LRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQR 489
RKR + A ++ Q L L L + +E + +Q QV
Sbjct: 1535 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1594
Query: 490 EEPAPEEEEPLLLQRPERVQTLEELEELGKEECFQNKELPRPV-LEGQQSERTPNNRPDA 548
E E L +R + +LE +EE +L QQ R +A
Sbjct: 1595 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1654
Query: 549 PKEKKKKEQMIDLQNLLTTQSPSV---KSLAVPTIEELEDEEERNHRQMIK---EAFAGD 602
+E ++ + + L Q+ V KSLA E+ ++E ER R+ K +A
Sbjct: 1655 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1714
Query: 603 DVIRDFLKEKREAVEAS 619
++ L+++R+ E +
Sbjct: 1715 ELAEQELEKQRQLAEGT 1731
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 63.9 bits (154), Expect = 5e-10
Identities = 100/477 (20%), Positives = 198/477 (41%), Gaps = 75/477 (15%)
Query: 185 EQEIFNLLHKNKQPVTDPLLTPVEKASLR--AMSLEEAKMRRAELQRARALQSYYEAKA- 241
E++ LL K+ + D + EK S++ + + +++R EL+ R L S K
Sbjct: 1052 EKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEI 1111
Query: 242 ----------------RREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVN-PAAALEELE 284
+++K+ S K V+ K K + +L+ + ++ + +++ ++E
Sbjct: 1112 QSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIE 1171
Query: 285 KIEKARMMERMSLKH------------------QNSGKWAKSKAIMAKYDLEARQAMQEQ 326
++ + E S + Q+SG A SK++ D + E
Sbjct: 1172 DDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPEN 1231
Query: 327 LSKNKELTQKLQVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKE 386
K L ++++ A+ S +E+G ++D E + N + P ++ + +
Sbjct: 1232 RIAKKMLLEEIK-ANLSSDEDGSSDDEPE---EGKKRTGKQNEENPGDEEAKNQVNSESD 1287
Query: 387 AATQED--PEQLPELEAHGVSESEGEERPVAEEEILLREFEERRSLRKRSELSQDAEPAG 444
+ ++E P L H ++ S+GE E++ +E +E + +R S+D+E +
Sbjct: 1288 SDSEESKKPRYRHRLLRHKLTVSDGESGE--EKKTKPKEHKEVKGRNRRKVSSEDSEDSD 1345
Query: 445 SQETKDSGSQEVLSEL------RVLSQK---LKENHQSRKQK-----------ASSEGTI 484
QE SG E +SE R S K L+EN +S KQK +SSE
Sbjct: 1346 FQE---SGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKS 1402
Query: 485 PQVQREEPAPEEEEPLLLQRPERVQTLEELEELGK-----EECFQNKELPRPVLEGQQSE 539
+ EE EEEE + E ++ + GK + ++ +L + E
Sbjct: 1403 NSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEE 1462
Query: 540 RTPNNR-PDAPKEKKKKEQMIDLQNLLTTQSPSVKSLAVPTIEELEDEEERNHRQMI 595
R + +E++K ++I++++ T+ P L + EE ++ + HR M+
Sbjct: 1463 EERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETKEPLVQVHRNMV 1519
Score = 35.4 bits (80), Expect = 0.20
Identities = 51/268 (19%), Positives = 112/268 (41%), Gaps = 23/268 (8%)
Query: 234 QSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARMME 293
Q+ + K +R++K + KKGK+ K+ ++ R+ ++ + E ++ + M
Sbjct: 732 QAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMS 791
Query: 294 RMSLKHQNSGKWAKSKAIMAKYDLE-ARQAMQEQLSKNKELTQKLQVASESEEEEGGTED 352
++ + +K + D + +++ M Q KN + +Q EG ++D
Sbjct: 792 KIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQ-----------EGSSDD 840
Query: 353 VEELLVPDVVNEVQMNADGPNPWM-LRSCTSDTKEAATQEDPEQLPELEAHGVSESEGEE 411
E + + + D M LR ++A+ D + +L S + E
Sbjct: 841 AERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDG--VDKLSGKEQSFTSLEV 898
Query: 412 RPVAEEEILLREFEERRSLRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENH 471
R VAE + + + + + + LS AE ++ D S++ + + +++ K+
Sbjct: 899 RKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPS 958
Query: 472 QSRKQ--------KASSEGTIPQVQREE 491
+K+ ++SS+GT +REE
Sbjct: 959 DFKKKVIKMEQQYESSSDGTEKLPEREE 986
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 63.9 bits (154), Expect = 5e-10
Identities = 100/477 (20%), Positives = 198/477 (41%), Gaps = 75/477 (15%)
Query: 185 EQEIFNLLHKNKQPVTDPLLTPVEKASLR--AMSLEEAKMRRAELQRARALQSYYEAKA- 241
E++ LL K+ + D + EK S++ + + +++R EL+ R L S K
Sbjct: 1090 EKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEI 1149
Query: 242 ----------------RREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVN-PAAALEELE 284
+++K+ S K V+ K K + +L+ + ++ + +++ ++E
Sbjct: 1150 QSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIE 1209
Query: 285 KIEKARMMERMSLKH------------------QNSGKWAKSKAIMAKYDLEARQAMQEQ 326
++ + E S + Q+SG A SK++ D + E
Sbjct: 1210 DDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPEN 1269
Query: 327 LSKNKELTQKLQVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKE 386
K L ++++ A+ S +E+G ++D E + N + P ++ + +
Sbjct: 1270 RIAKKMLLEEIK-ANLSSDEDGSSDDEPE---EGKKRTGKQNEENPGDEEAKNQVNSESD 1325
Query: 387 AATQED--PEQLPELEAHGVSESEGEERPVAEEEILLREFEERRSLRKRSELSQDAEPAG 444
+ ++E P L H ++ S+GE E++ +E +E + +R S+D+E +
Sbjct: 1326 SDSEESKKPRYRHRLLRHKLTVSDGESGE--EKKTKPKEHKEVKGRNRRKVSSEDSEDSD 1383
Query: 445 SQETKDSGSQEVLSEL------RVLSQK---LKENHQSRKQK-----------ASSEGTI 484
QE SG E +SE R S K L+EN +S KQK +SSE
Sbjct: 1384 FQE---SGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKS 1440
Query: 485 PQVQREEPAPEEEEPLLLQRPERVQTLEELEELGK-----EECFQNKELPRPVLEGQQSE 539
+ EE EEEE + E ++ + GK + ++ +L + E
Sbjct: 1441 NSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEE 1500
Query: 540 RTPNNR-PDAPKEKKKKEQMIDLQNLLTTQSPSVKSLAVPTIEELEDEEERNHRQMI 595
R + +E++K ++I++++ T+ P L + EE ++ + HR M+
Sbjct: 1501 EERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETKEPLVQVHRNMV 1557
Score = 35.4 bits (80), Expect = 0.20
Identities = 51/268 (19%), Positives = 112/268 (41%), Gaps = 23/268 (8%)
Query: 234 QSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARMME 293
Q+ + K +R++K + KKGK+ K+ ++ R+ ++ + E ++ + M
Sbjct: 770 QAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMS 829
Query: 294 RMSLKHQNSGKWAKSKAIMAKYDLE-ARQAMQEQLSKNKELTQKLQVASESEEEEGGTED 352
++ + +K + D + +++ M Q KN + +Q EG ++D
Sbjct: 830 KIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQ-----------EGSSDD 878
Query: 353 VEELLVPDVVNEVQMNADGPNPWM-LRSCTSDTKEAATQEDPEQLPELEAHGVSESEGEE 411
E + + + D M LR ++A+ D + +L S + E
Sbjct: 879 AERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDG--VDKLSGKEQSFTSLEV 936
Query: 412 RPVAEEEILLREFEERRSLRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENH 471
R VAE + + + + + + LS AE ++ D S++ + + +++ K+
Sbjct: 937 RKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPS 996
Query: 472 QSRKQ--------KASSEGTIPQVQREE 491
+K+ ++SS+GT +REE
Sbjct: 997 DFKKKVIKMEQQYESSSDGTEKLPEREE 1024
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 63.5 bits (153), Expect = 7e-10
Identities = 91/472 (19%), Positives = 198/472 (41%), Gaps = 54/472 (11%)
Query: 101 ATVKKQLSRVKSKKTVELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFP 160
A ++++L V+S+K+ E+ LN +E++R Q L + K Q+
Sbjct: 224 AKLQEKLQLVESEKS-EIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQ 282
Query: 161 LEKEEPAIAPIEHVLSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSL--E 218
+ EE + W ++E + Q + + EK + + +
Sbjct: 283 AQVEENEL---------WNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ 333
Query: 219 EAKMRRAEL------QRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLR 272
E KMRR E ++ R + K + ++++ + K K + ++ + E E++R
Sbjct: 334 EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIR 393
Query: 273 KVNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKE 332
+ +E ++ E+ ++ E+ + Q + W + + I E + ++EQ K
Sbjct: 394 E-------QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR-----EQEEKIREQEKKMWR 441
Query: 333 LTQKLQVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQED 392
+K+ + EEE E E + + E + W + + ++ QE+
Sbjct: 442 QEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQE------EIWRQKEKMHEQEKIRKQEE 495
Query: 393 PEQLPELEAHGVSES--EGEERPVAEEEILLREFEERRSLRKRSELSQDAEPAGSQETKD 450
E + H E E EE+ +EE +RE EE+ +R++ E ++ E ++ +
Sbjct: 496 KVWRQEEKMHDQEEKIREQEEKMWRQEE-KIREQEEK--IREQEEKIREQEEMMQEQEEK 552
Query: 451 SGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLLQRPERVQT 510
G QE +K++E + R+Q+ +++ ++ E+E + ++ E+++
Sbjct: 553 MGEQE---------EKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIRE 603
Query: 511 LEELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMIDLQ 562
EE+ + +E+ ++ +E E Q + R +E+K EQ + L+
Sbjct: 604 QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR----QEEKMWEQEVRLR 651
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 63.5 bits (153), Expect = 7e-10
Identities = 79/398 (19%), Positives = 166/398 (41%), Gaps = 30/398 (7%)
Query: 218 EEAKMRRAELQ-RARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNP 276
EE K + AELQ + R +S K++K K + + + E R+
Sbjct: 183 EELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEE 242
Query: 277 AAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQK 336
E+ + ++ +M + + GK + + M + + R+ +E + KEL ++
Sbjct: 243 LREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQ 302
Query: 337 LQVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQL 396
++ + E+ + E + E E +M W +E E +Q+
Sbjct: 303 KKLREQEEQMQEQEEKMWE-------QEEKMREQEEKMW--------RQEERLWEQEKQM 347
Query: 397 PELEAHGVSESEGEERPVAEEEILLREFEER----RSLRKRSELSQDAEPAGSQETKDSG 452
E E + +E + E++ LRE EER + ++ E Q+ E +E K
Sbjct: 348 REQE----QKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMRE 403
Query: 453 SQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQR---EEPAPEEEEPLLLQRPERVQ 509
+E + E QK +EN +++K + +P+ + E+ +E+E + ++ E+++
Sbjct: 404 EEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIR 463
Query: 510 TLEELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMIDLQNLLTTQS 569
EE+ G+E+ +E R E Q E+ R K ++E+M + L +
Sbjct: 464 DQEEM--WGQEKKMWRQEKMRE-QEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKE 520
Query: 570 PSVKSLAVPTIEELEDEEERNHRQMIKEAFAGDDVIRD 607
++ +E + EE+ ++ K+ + ++ +R+
Sbjct: 521 ERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMRE 558
Score = 60.5 bits (145), Expect = 6e-09
Identities = 70/356 (19%), Positives = 147/356 (41%), Gaps = 18/356 (5%)
Query: 213 RAMSLEEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLR 272
+ M +E KMR Q R + + + E+ + +K + +K + ++ ++E E+
Sbjct: 345 KQMREQEQKMRD---QEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKM 401
Query: 273 KVNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKE 332
+ E+ EK++K + ++ Q +W + + K L ++ MQEQ K E
Sbjct: 402 REEEETMREQEEKMQK----QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWE 457
Query: 333 LTQKLQVASE---SEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAAT 389
+K++ E E++ E + E E +M W + E
Sbjct: 458 QEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLR 517
Query: 390 QEDPEQLPELEAHGVSESEGEERPVAEEEILLREFEER-----RSLRKRSELSQDAEPAG 444
+++ + + E EE+ E+E + EE+ R + ++ ++ E
Sbjct: 518 EKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMR 577
Query: 445 SQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLLQR 504
QE K +E + E + +E Q +++K + Q EE +E+E ++ ++
Sbjct: 578 EQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQ 637
Query: 505 PERVQTLEELEELGKEECFQNKELPR---PVLEGQQSERTPNNRPDAPKEKKKKEQ 557
E++Q EE +E+ + +E R ++GQ+ + +E+K +EQ
Sbjct: 638 EEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQ 693
Score = 59.3 bits (142), Expect = 1e-08
Identities = 82/382 (21%), Positives = 157/382 (41%), Gaps = 31/382 (8%)
Query: 218 EEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPA 277
+E KM+ E R R + E + RE++ K +K ++ ++ KE++Q R
Sbjct: 384 QEEKMQEEERIREREKKMREEEETMREQEEKMQKQ----EENMWEQEEKEWQQQRLPEQK 439
Query: 278 AALEELEKIEKA--RMMERMSLKHQNSGKWAKSKAIMAKYDL-EARQAMQEQLSKNKELT 334
L E EK+++ ++ E+ W + K + + + E M EQ K ++
Sbjct: 440 EKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQE 499
Query: 335 QKLQVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPE 394
QK+ ++EE E E L + Q M + +E T + E
Sbjct: 500 QKMW-----DQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEE 554
Query: 395 QLPELEAHGVSESEGEERPVAEEEILLREFEERRSLRKRSELSQDAEPAGSQETKDSGSQ 454
++ E E E+ + EEE ++RE EE+ + ++ + E QE K +
Sbjct: 555 KMREEE-----RMREREKKMREEEEMMREQEEKMQ-EQEEKMREQEEKMWEQEEKMQEQE 608
Query: 455 EVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLLQRPERVQTLEEL 514
E + E + +E + ++Q+ ++Q +E E+E + ++ E+++ EE
Sbjct: 609 EKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEK 668
Query: 515 EELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMIDLQNLLTTQSPSVKS 574
+ G+EE + +E E + E+ R K ++E+M + + Q
Sbjct: 669 MQ-GQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQ------ 721
Query: 575 LAVPTIEELEDEEERNHRQMIK 596
EE+ ++EER Q K
Sbjct: 722 ------EEMREKEERIRDQKEK 737
Score = 58.5 bits (140), Expect = 2e-08
Identities = 144/720 (20%), Positives = 286/720 (39%), Gaps = 100/720 (13%)
Query: 12 ALSQQEELADLPKDYLLSESEDEGDNDGERKH-----QKLLEAISSLDGKNRRKLAE--- 63
AL ++ A +D L ES+D H Q+ L A+S+ K R + E
Sbjct: 107 ALYYSQDAARKFEDGNLGESKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTK 166
Query: 64 -RSEASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSS--------LATVKKQLSRVK--- 111
R SL++ +++E +K A+L E ++ + S + +K++L R K
Sbjct: 167 ERDALSLELYRNTITNEELKKKN--AELQEKLRLAESEKSEIQLNVKELKRKLERAKFLL 224
Query: 112 ---SKKTVELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAI 168
T++ + ++E E +E K + + + + R EQ E+EE
Sbjct: 225 PQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQE-----ERLREQEGKMREQEEKMR 279
Query: 169 APIEHVLSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAELQ 228
+ + K E+E+ K + + + EK M +E KMR E +
Sbjct: 280 RQEKRLREQEKELREQEKELRE--QKKLREQEEQMQEQEEK-----MWEQEEKMREQEEK 332
Query: 229 RARALQSYYEA-KARREKKIKSKKYHKVV---------KKGKAKKALKEFEQLRKVNPAA 278
R + +E K RE++ K + + + K+ + ++ K +EQ K+
Sbjct: 333 MWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEE 392
Query: 279 ALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQ 338
+ E EK +M E + K K + M ++ E ++ Q++L + KE + +
Sbjct: 393 RIREREK----KMREEEETMREQEEKMQKQEENM--WEQEEKEWQQQRLPEQKEKLWEQE 446
Query: 339 VASESEE----EEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPE 394
E EE +E D EE+ G M R +E E E
Sbjct: 447 KMQEQEEKIWEQEEKIRDQEEMW-------------GQEKKMWRQEKMREQEDQMWEQEE 493
Query: 395 QLPELEAHGVSESEGEERPVAEEEILLREFEERRSLRKR----SELSQDAEPAGSQETKD 450
++ + E + +E + E++ LRE EER +K+ E ++ + QE K
Sbjct: 494 KMRDQE----QKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKT 549
Query: 451 SGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLLQRPERVQT 510
+E + E + ++ K+ + + E + + +EE E+EE + ++ E++Q
Sbjct: 550 WDQEEKMREEERMREREKKMREEEEMMREQEEKMQE--QEEKMREQEEK-MWEQEEKMQE 606
Query: 511 LEELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMIDLQNLLTTQSP 570
EE +E+ ++ +E E + E+ K ++++E+M + + + Q
Sbjct: 607 QEEKMWEQEEKMWEQEE------EDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEE 660
Query: 571 SVKSLAVPTIEELEDEEERNHRQMIKEAFAGDDVIRDFLKEKREAVEASKPKDVDLTLPG 630
++ E+++ +EE+ Q +E G + + ++E+ E + + K
Sbjct: 661 KMREQE----EKMQGQEEKMREQ--EEKMQGQE---EKMREQEEKMRGQEEKMWGQEEKM 711
Query: 631 WGE----WGGVGLKPSAKKRRRFLIKAPEGPPRKDKNLPNVIINEKRNIHAAAHQVRVLP 686
WG+ WG ++ ++ R K E P ++ + + + +H V P
Sbjct: 712 WGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEERCSEPCLPPSKVLCNMSHTGSVEP 771
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 63.2 bits (152), Expect = 9e-10
Identities = 86/411 (20%), Positives = 175/411 (42%), Gaps = 59/411 (14%)
Query: 217 LEEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNP 276
++E +R+ E+ + + E + + E+KI++K HK +KGK K KE P
Sbjct: 133 IDEPPLRKKEIHKDKT-----EKQEKPERKIQTKVTHKEKEKGKEKVREKE-------KP 180
Query: 277 AAALEELEKIEKARMMERMSL-KHQNSGKWAKSKAIMAKYDLEA--RQAMQEQLSKNKEL 333
EKIEK E +L K Q K A+ K +++ ++ +++ +K KE+
Sbjct: 181 EKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEV 240
Query: 334 TQKLQVASESEEEEGGT----EDVEELLVPDVVNEVQMNAD---GPNPWMLRSCTSDTKE 386
+ E E++E E ++ + ++ ++ D G +P + ++
Sbjct: 241 QKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQAS 300
Query: 387 AATQEDPEQLPELEAHGVSESEGEERPVAEEEILLREFEERRSLRKRSELS-----QDAE 441
T P + E EGE++ ++ + +E+ ++K+SE + E
Sbjct: 301 RPTPASP---------ALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKE 351
Query: 442 PAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQRE-----EPA--P 494
P + ETK G+ ++ ++ + KE+ + K+ A E + Q + EPA P
Sbjct: 352 PGKASETK-QGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSP 410
Query: 495 EEEEPLLLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKK 554
++E + + + +T EE+G + + G++ E+T +++ +
Sbjct: 411 KKEHSVPSDKQVKAKTERAKEEIGAVSI-------KKAVPGKKEEKTTK----TVEQEIR 459
Query: 555 KEQMIDLQNLLTTQSP-SVKSLAVPTIEELEDEEERNHRQMIKEAFAGDDV 604
KE+ ++L + P K VP + ++ E + +M K AG +V
Sbjct: 460 KEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSK---AGKEV 507
Score = 48.1 bits (113), Expect = 3e-05
Identities = 105/554 (18%), Positives = 223/554 (40%), Gaps = 58/554 (10%)
Query: 31 SEDEGDNDGERKHQKLLEAISSLDG---------KNRRKLAERSEASLKVSEFNVSSEGS 81
SEDE D+DG+ K +D K++ + E+ E ++ + E
Sbjct: 116 SEDEEDDDGDEDTDK-----GEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKG 170
Query: 82 GEKLVLADLLEPVKT-SSSLATVKKQLSRVKSKKTVELPLNKEEIERIHREVAFNKTAQV 140
EK+ + E T + +K ++ +K+ + ++ E+ +EV K +V
Sbjct: 171 KEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKV 230
Query: 141 LSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVLSGWKARTPLEQEIFNLLHKNKQPVT 200
V + + +KE+ A++ E R ++ + L + P
Sbjct: 231 KQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAI 290
Query: 201 DPLLTPVEKASLRAMSLEEAKMRRAELQRA-RALQSYYEAKARREKKIKSKKYHKV-VKK 258
P L P E+AS + + + E ++A + + S + K + + K KS+K + V+K
Sbjct: 291 PPPL-PTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEK 349
Query: 259 GKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLE 318
+ KA + + K+ AA ++ EK E ++ ++ + Q GK + K K+
Sbjct: 350 KEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKE---KHVEP 406
Query: 319 ARQAMQEQ-LSKNKELTQKLQVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWML 377
A+ +E + +K++ K + A +EE G +
Sbjct: 407 AKSPKKEHSVPSDKQVKAKTERA---KEEIGAVS-------------------------I 438
Query: 378 RSCTSDTKEAATQEDPEQLPELEAHGVSESEGEER-PVA--EEEILLREFEERRSLRKRS 434
+ KE T + EQ E G + S +++ P+ EE++ E+ +K
Sbjct: 439 KKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDE 498
Query: 435 ELSQDAEPAGSQETKDSGSQEVLSELRVLSQK---LKENHQSRKQK-ASSEGTIPQVQRE 490
++S+ + + + G +E E ++ + + E Q KQ E T+ + E
Sbjct: 499 KMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPE 558
Query: 491 EPAPEEEEPLLLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPK 550
E ++ + + +++ + + ++ E +E + P+P +G SE T + +
Sbjct: 559 EKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKG-TSEVTESGKKKTEI 617
Query: 551 EKKKKEQMIDLQNL 564
+K+ ++ D+++L
Sbjct: 618 SEKESKEKADMKHL 631
Score = 41.2 bits (95), Expect = 0.004
Identities = 59/305 (19%), Positives = 118/305 (38%), Gaps = 28/305 (9%)
Query: 339 VASESEEEEGGTEDVEE-------LLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQE 391
++SE EE++ G ED ++ L ++ + + P + T KE ++
Sbjct: 114 ISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEK 173
Query: 392 DPE-QLPELEAHGVSESEGEERPVAEEEILLREFEERRSLRKRSELSQDAEPAGSQETKD 450
E + PE +A + E +E+P E + L +E ++ ++ K E ++ G QE
Sbjct: 174 VREKEKPEKKATHKEKIEKKEKP--ETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVK 231
Query: 451 SGSQEVLSELRVLSQKLKE----------NHQSRKQKASSEGTIPQVQREEPAPEEEEPL 500
+ +V E++ K KE H+ + Q A I + P + +
Sbjct: 232 QTAAKV-KEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAI 290
Query: 501 LLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMID 560
P + T + + KE + E + + T + K+K +KE ID
Sbjct: 291 ----PPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAID 346
Query: 561 LQNLLTTQSPSVKSLAVPTIEEL---EDEEERNHRQMIKEAFAGDDVIRDFLKEKREAVE 617
++ ++ K V + +DE++ + ++ K A + K+++
Sbjct: 347 VEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEP 406
Query: 618 ASKPK 622
A PK
Sbjct: 407 AKSPK 411
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 61.6 bits (148), Expect = 3e-09
Identities = 114/602 (18%), Positives = 258/602 (42%), Gaps = 70/602 (11%)
Query: 27 LLSESEDEGDNDGERKHQKLLEAISSLDGKNRRKLAE----RSEASLKVSEFNVSSEGSG 82
L+S D GE ++ L A+++ K R + E R SL++ ++ E
Sbjct: 163 LISRLHDSWKFAGEL--EQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELK 220
Query: 83 EKLV-LADLLEPVKTSSSLATVK-KQLSRVKSKKTVELPLNKEEIERIHREVAFNK-TAQ 139
EK L + L+ V++ S + K+L R + + LP + + E H +A+
Sbjct: 221 EKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK 280
Query: 140 VLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVLSGWKARTPLEQEIFNLLHKNKQPV 199
+ ++ + L NR +Q + ++E I E + + + ++E + +
Sbjct: 281 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ 340
Query: 200 TDPLLTPVEKASLRAMSL--EEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVK 257
+ + EK + + +E KMRR E + E K RR++++ +K K+
Sbjct: 341 EEMMWEKEEKMRRQEEMMWEKEEKMRRQE-----EMMWEKEEKMRRQEEMMWEKEEKI-- 393
Query: 258 KGKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDL 317
+ ++ + E E++R+ +E ++ E+ ++ E+ + Q + W + + I
Sbjct: 394 -RELEEKMHEQEKIRE-------QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR----- 440
Query: 318 EARQAMQEQLSKNKELTQKLQVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWML 377
E + ++EQ K +K+ + EEE E E + ++E + W
Sbjct: 441 EQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQE------EIWRQ 494
Query: 378 RSCTSDTKEAATQEDP------EQLPELEAHGVSESEG---EERPVAEEEILLREFEERR 428
+ + +E +++ E++ E E + E +E + E+E + RE E+
Sbjct: 495 KEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMH 554
Query: 429 SLRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSR-KQKASSEGTIPQV 487
K E + E ++ +E ++ +K++E + R +Q+ ++
Sbjct: 555 EQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKI 614
Query: 488 QREEPAPEEEEPLLLQRPERVQTLEEL-----EELGKEE---CFQNKELPRPVLEGQQSE 539
+ +E +E+E + ++ E+++ EE+ E++G++E C Q +++ Q+ E
Sbjct: 615 REQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKM-------QEQE 667
Query: 540 RTPNNRPDAPKEKKKK-----EQMIDLQNLLTTQSPSV---KSLAVPTIEELEDEEERNH 591
T + + +E++KK E++ + + ++ Q + + E+++++EE+
Sbjct: 668 ETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMR 727
Query: 592 RQ 593
RQ
Sbjct: 728 RQ 729
Score = 60.5 bits (145), Expect = 6e-09
Identities = 116/593 (19%), Positives = 246/593 (41%), Gaps = 98/593 (16%)
Query: 3 ANRLAESLLALSQQEELADLPKDYLLSESEDEG---------DNDGERKHQKLLEAISSL 53
A L ++L A++ Q++ AD + L E + D + + K+ KL E + +
Sbjct: 174 AGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLV 233
Query: 54 DGKNRRKLAERSEASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSSLAT-VKKQLSRVKS 112
+ +E+SE L V E KL A LL P + + A + K+L V +
Sbjct: 234 E-------SEKSEIQLNVKELK-------RKLERAKLLLPQQQLQAEADHLGKELQSVSA 279
Query: 113 KKTVELP-------LNKEEIERIHREVAFNKTAQVLSKWDPVVL---------------- 149
K ++ LN+++ E++ R+ + + +W+ +
Sbjct: 280 KLQAQVEENELWNRLNQQQEEKMWRQ------EEKIQEWEEKIQEQEEKIREQEEKIREQ 333
Query: 150 --KNRQAEQLVFPLEKEEPAIAPIEHVLSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPV 207
K R+ E++++ EKEE E + W+ + ++ + K ++ +
Sbjct: 334 EEKMRRQEEMMW--EKEEKMRRQEEMM---WEKEEKMRRQEEMMWEKEEKMRRQEEMMWE 388
Query: 208 EKASLRAMSL---EEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAK-- 262
++ +R + E+ K+R E +R + E + R+E++ K + + +++ + K
Sbjct: 389 KEEKIRELEEKMHEQEKIREQEEKRQEE-EKIREQEKRQEQEAKMWRQEEKIREQEEKIR 447
Query: 263 -KALKEFEQLRKVNPAAALEELEKIEKARMMERMSLK-HQNSGKWAKSKAIMAKYDLEAR 320
+ K + Q K++ + E EK ++ M R K H+ W + + + + + +
Sbjct: 448 EQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRK 507
Query: 321 QA---------MQEQLSKNKELTQKLQVASES--EEEEGGTEDVEELLVPDVVNEVQMNA 369
Q ++EQ K +E +K+ E E+EE E+ + + E +
Sbjct: 508 QEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQE 567
Query: 370 DGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGVSESEG----------EERPVAEEEI 419
W + +E +++ E++ E E + E +E + E+E
Sbjct: 568 QEDKMWRQEEKIREQEEKVWRQE-EKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEE 626
Query: 420 LLREFEERRSLRKRSELSQDAEPA-GSQETKDSGSQEVLSELRVL----SQKLKENHQS- 473
+RE EE+ +R++ E++Q+ E G QE K +E + E +K++E +
Sbjct: 627 KIREQEEK--IREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKI 684
Query: 474 RKQKASSEGTIPQVQREEPAPEEEEPLLLQRPERVQTLEELEELGKEECFQNK 526
R+Q+ +Q +E E+E + ++ E++Q EE +E+ ++ +
Sbjct: 685 REQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQE 737
Score = 46.6 bits (109), Expect = 9e-05
Identities = 113/538 (21%), Positives = 219/538 (40%), Gaps = 98/538 (18%)
Query: 98 SSLATVKKQLSRVKSKKTVELPLNKEEIER--IHREVAFNKTAQVLSKWDPVVLKNRQAE 155
S++AT KK+ R + T E E+ R I E K A++ K V + + +
Sbjct: 182 SAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQ 241
Query: 156 QLVFPLEKEEPAIAPIEHVLSGWKARTPLEQEIFNLLHKNK--QPVTDPLLTPVEKASL- 212
V L+++ L K P +Q H K Q V+ L VE+ L
Sbjct: 242 LNVKELKRK----------LERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELW 291
Query: 213 -RAMSLEEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQL 271
R +E KM R E +Q + E +E+KI+ ++ +K ++ E++
Sbjct: 292 NRLNQQQEEKMWRQE----EKIQEWEEKIQEQEEKIREQE----------EKIREQEEKM 337
Query: 272 RKVNPAAALEEL--EKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSK 329
R+ EE+ EK EK R E M W K E + QE++
Sbjct: 338 RRQ------EEMMWEKEEKMRRQEEMM--------WEK----------EEKMRRQEEMMW 373
Query: 330 NKELTQKLQVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAAT 389
KE + Q E+EE E E++ + + E +E
Sbjct: 374 EKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIRE--------------------QEEKR 413
Query: 390 QEDPEQLPELEAHGVSESEGEERPVAEEEILLREFEERRSLRKRSELSQDAEPAGSQETK 449
QE+ E++ E E + + +E + +E +RE EE+ +++ Q+ + ++ +
Sbjct: 414 QEE-EKIREQE-----KRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIR 467
Query: 450 DSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLLQRPERVQ 509
+ ++ E+ +K+ E + +QK ++EE ++EE + Q E+++
Sbjct: 468 EEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMH------EQEEKIRKQEEKVWRQE-EKIR 520
Query: 510 TLEELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMIDLQNLLTTQS 569
EE +E+ ++ +E R E + E + + +E+K++EQ ++ + Q
Sbjct: 521 EQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQ----EDKMWRQE 576
Query: 570 PSVKSL--AVPTIEELEDEEERNHRQMIKEAFAGDDVIR---DFLKEKREAVEASKPK 622
++ V EE E+E ++ ++ + ++ IR + ++E+ E + + K
Sbjct: 577 EKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEK 634
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 61.2 bits (147), Expect = 3e-09
Identities = 77/383 (20%), Positives = 168/383 (43%), Gaps = 44/383 (11%)
Query: 218 EEAKMRRAELQRARALQSYYEA--KARREKKIKS--KKYHKVVKKGKAKKALKEFEQLRK 273
E+ + R + +R R + +E K R EKK++ KK +K + ++ ++E E+ +
Sbjct: 401 EQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMR 460
Query: 274 VNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKEL 333
E+ EK++K + ++ Q +W + + K L ++ MQEQ K E
Sbjct: 461 EEEETMREQEEKMQK----QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQ 516
Query: 334 TQKLQVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQEDP 393
+K++ +EE G E + + +M W +E ++
Sbjct: 517 EEKIR----DQEEMWGQE-------KKMWRQEKMREQEDQMW--------EQEEKMRDQE 557
Query: 394 EQLPELEAHGVSESEGEERPVAEEEILLREFEERRSLRKRSELSQDAEPAGSQETKDSGS 453
+++ + E +++ +E+ ++E +RE E R K+ + ++ E QE K
Sbjct: 558 QKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKK--MREEEEMMREQEEKMQEQ 615
Query: 454 QEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLLQR--PERVQTL 511
+E + E + +E Q +++K ++EE E+EE + Q+ PE+ + L
Sbjct: 616 EEKMQEQEEKMWEQEEKMQEQEEK--------MWEQEEKMWEQEEKMWEQQRLPEQKEKL 667
Query: 512 EELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEK-KKKEQMIDLQNLLTTQSP 570
E E++ ++E Q +E E + + + +EK +++E M + + + +
Sbjct: 668 WEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEE 727
Query: 571 SVKSLAVPTIEELEDEEERNHRQ 593
++ E+++++EE+ Q
Sbjct: 728 MMREQE----EKMQEQEEKMQEQ 746
Score = 60.1 bits (144), Expect = 8e-09
Identities = 97/469 (20%), Positives = 187/469 (39%), Gaps = 45/469 (9%)
Query: 111 KSKKTVELPLNKEEIERIH-REVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIA 169
+ KKT + +E ERI RE + + + + + + K Q E + EKE
Sbjct: 435 QEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQK--QEENMWEQEEKEWQQQR 492
Query: 170 PIEHVLSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAELQR 229
E W+ EQE + + ++ + D M +E KM R E R
Sbjct: 493 LPEQKEKLWEQEKMQEQE--EKIWEQEEKIRDQ----------EEMWGQEKKMWRQEKMR 540
Query: 230 ARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKA 289
+ Q + + + R+++ K + ++K ++ K ++Q K+ + E EK
Sbjct: 541 EQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREK---- 596
Query: 290 RMMERMSLKHQNSGKWAKSKAIMAKYD---LEARQAMQEQLSKNKELTQKLQVASESE-E 345
+M E + + K + + M + + E + MQEQ K E +K+ E E
Sbjct: 597 KMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWE 656
Query: 346 EEGGTEDVEELLVPDVVNEVQ-MNADGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGV 404
++ E E+L + + E + M W + E TQE ++ + E
Sbjct: 657 QQRLPEQKEKLWEHEKMQEQEKMQEQEEKIW-----EQEKMEKKTQEQEKKTWDQEKMRE 711
Query: 405 SESEGE-ERPVAEEEILLREFEERRSLRKRSELSQDAEPAGSQETKDSGSQEVLSELRVL 463
ES E E+ + EEE ++RE EE+ ++ Q+ E +E +++ + R+
Sbjct: 712 EESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLP 771
Query: 464 SQKLK---------------ENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLLQRPERV 508
QK K + + R Q+ G +++ +E +E + + E++
Sbjct: 772 EQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKM 831
Query: 509 QTLEELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQ 557
EE +E+ + +E ++GQ+ + +E+K +EQ
Sbjct: 832 WGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQ 880
Score = 58.5 bits (140), Expect = 2e-08
Identities = 85/391 (21%), Positives = 165/391 (42%), Gaps = 41/391 (10%)
Query: 218 EEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPA 277
+E KM+ E R R + E + RE++ K +K ++ ++ KE++Q R
Sbjct: 442 QEEKMQEEERIREREKKMREEEETMREQEEKMQKQ----EENMWEQEEKEWQQQRLPEQK 497
Query: 278 AALEELEKIEKA--RMMERMSLKHQNSGKWAKSKAIMAKYDL-EARQAMQEQLSKNKELT 334
L E EK+++ ++ E+ W + K + + + E M EQ K ++
Sbjct: 498 EKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQE 557
Query: 335 QKL-----QVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAAT 389
QK+ ++ +++E+E T D EE + + + M+R +E
Sbjct: 558 QKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMRE-----QEEKM 612
Query: 390 QEDPEQLPELEAHGVSESEG----EERPVAEEEILLREFE---ERRSLRKRSELSQDAEP 442
QE E++ E E + E EE+ +EE + + E E++ L ++ E + E
Sbjct: 613 QEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEK 672
Query: 443 AGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLL 502
QE K +E + E + +K +E + + +RE+ EEEE ++
Sbjct: 673 MQEQE-KMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEE-MMR 730
Query: 503 QRPERVQTLEELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMIDLQ 562
++ E++Q EE + +EE ++ +E + Q+ + R KEK + + + Q
Sbjct: 731 EQEEKMQEQEEKMQEQEEEMWEQEE----KMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ 786
Query: 563 NLLTTQSPSVKSLAVPTIEELEDEEERNHRQ 593
+ Q E++ D+EE+ Q
Sbjct: 787 EKIWEQE-----------EKMRDQEEKMRGQ 806
Score = 54.7 bits (130), Expect = 3e-07
Identities = 82/421 (19%), Positives = 177/421 (42%), Gaps = 39/421 (9%)
Query: 218 EEAKMRRAELQRARALQSYYEAKARRE-KKIKSKKYHKVVKKGKAKKALKEFEQLRKVNP 276
EE K + AELQ L +++ + K++K K + + + E R+
Sbjct: 221 EELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEE 280
Query: 277 AAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQK 336
E+ + ++ +M + + GK + + M + + R+ +E + KEL ++
Sbjct: 281 LREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQ 340
Query: 337 LQVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQL 396
++ + E+ + E + E E +M W +E E +Q+
Sbjct: 341 KELREQEEQMQEQEEKMWE-------QEEKMREQEEKMW--------RQEERLWEQEKQM 385
Query: 397 PELEAHGVSESEGEERPVAEEEILLREFEER----RSLRKRSELSQDAEPAGSQETKDSG 452
E E + +E + E++ LRE EER + ++ E ++ + QE K
Sbjct: 386 REQE----QKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRD 441
Query: 453 SQEVLSE---LRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLLQR-PERV 508
+E + E +R +K++E ++ +++ Q Q E +EE+ QR PE+
Sbjct: 442 QEEKMQEEERIREREKKMREEEETMREQEEK----MQKQEENMWEQEEKEWQQQRLPEQK 497
Query: 509 QTLEELEELGKEE--CFQNKELPRPVLE--GQQSE--RTPNNRPDAPKEKKKKEQMIDLQ 562
+ L E E++ ++E ++ +E R E GQ+ + R R + +++E+M D +
Sbjct: 498 EKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQE 557
Query: 563 NLLTTQSPSVKSLAVPTIEELEDEEER-NHRQMIKEAFAGDDVIRDFLKEKREAVEASKP 621
+ Q ++ ++ D+EE+ + ++E + ++E+ E ++ +
Sbjct: 558 QKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEE 617
Query: 622 K 622
K
Sbjct: 618 K 618
Score = 48.1 bits (113), Expect = 3e-05
Identities = 74/356 (20%), Positives = 151/356 (42%), Gaps = 36/356 (10%)
Query: 262 KKALKEFEQLRKVNPAAALE---------ELEKIEKARMMERMSLKHQNSG------KWA 306
KKA + E+L K A +LE EL+K + A + E++ L K
Sbjct: 193 KKADRYIEELTKERDALSLELYRNTITNEELKK-KNAELQEKLPLAESEKSEIQLNVKEL 251
Query: 307 KSKAIMAKYDLEARQA--MQEQLSKNKELTQKLQVASESEEEEGGTEDVEELLVPDVVNE 364
K K AK+ L Q +QE++ + +E ++ + +EE+ + EE L E
Sbjct: 252 KRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQ--EERLREQ---E 306
Query: 365 VQMNADGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGVSES-EGEERPVAEEEILLRE 423
+M W + ++ +++ E + E E + +E + E+E +RE
Sbjct: 307 GKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMRE 366
Query: 424 FEERRSLRKRSELSQDAEPAGSQETKDSGSQEVLSE----LRVLSQKLKENHQSRKQKAS 479
EE+ R+ L + + QE K +E + E LR ++++E + +Q
Sbjct: 367 QEEKM-WRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEK 425
Query: 480 SEGTIPQVQREEPAPEEEEPLLLQRP--ERVQTLEELEELGKEECFQNKELPRPVLEGQQ 537
++E+ ++EE + + ER + + E EE +E+ + ++ + E ++
Sbjct: 426 MREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEE 485
Query: 538 SERTPNNRPDAPKEKKKKEQMIDLQNLLTTQSPSVKSLAVPTIEELEDEEERNHRQ 593
E P+ ++ ++E+M + + + Q ++ EE+ +E++ RQ
Sbjct: 486 KEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ-----EEMWGQEKKMWRQ 536
Score = 40.0 bits (92), Expect = 0.008
Identities = 72/342 (21%), Positives = 149/342 (43%), Gaps = 56/342 (16%)
Query: 287 EKARMMERMSLKHQNSGKWAKS---KAIMAKYDLEARQAMQEQLSK-NKELTQKLQVASE 342
E R + +S +H+ + ++ + + +L E+L K N EL +KL +A E
Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLA-E 238
Query: 343 SEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQLPELEAH 402
SE+ E +L V ++ +++ ++L ++T + E+L E
Sbjct: 239 SEKSE------IQLNVKELKRKLERAK-----FLLPQVQTNTLQEEMWRQEEELRE---- 283
Query: 403 GVSESEGEERPVAEEEILLREFEERRSLRKRSELSQDAEPAGSQETKDSGSQEVLSELRV 462
+E+ + ++E + EER LR++ ++ E ++ K QE ELR
Sbjct: 284 -------QEKKIRKQEEKMWRQEER--LREQEGKMREQEEKMWRQEKRLREQE--KELRE 332
Query: 463 LSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLLQRPERVQTLEELEELGKEEC 522
++L+E + R+Q+ Q+Q +E E+E + ++ E++ E E L ++E
Sbjct: 333 QEKELREQKELREQE-------EQMQEQEEKMWEQEEKMREQEEKMWRQE--ERLWEQE- 382
Query: 523 FQNKELPRPVLEGQQSERTPNNRPDAPKEK-KKKEQMIDLQNLLTTQSPSVKSLAVPTIE 581
+ + E +Q R R E+ ++KE+ + Q + Q ++ E
Sbjct: 383 -------KQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMR-------E 428
Query: 582 ELEDEEERNHRQMIKEAFAGDDVIRDFLKEKREAVEASKPKD 623
E + +E+ + +E ++ IR+ K+ RE E + ++
Sbjct: 429 EKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQE 470
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 61.2 bits (147), Expect = 3e-09
Identities = 112/536 (20%), Positives = 224/536 (41%), Gaps = 64/536 (11%)
Query: 27 LLSESEDEGDNDGERKHQKLLEAISSLDGKNRRKLAE----RSEASLKVSEFNVSSEGSG 82
L+S D GE ++ L A+++ K R + E R SL++ ++ E
Sbjct: 224 LISRLHDSWKFAGEL--EQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELK 281
Query: 83 EKLV-LADLLEPVKTSSSLATVK-KQLSRVKSKKTVELPLNKEEIERIHREVAFNK-TAQ 139
EK L + L+ V++ S + K+L R + + LP + + E H +A+
Sbjct: 282 EKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK 341
Query: 140 VLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVLSGWKARTPLEQEIFNLLHKNKQPV 199
+ ++ + L NR +Q +E + E + W+ + ++E + +
Sbjct: 342 LQAQVEENELWNRLNQQ-------QEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ 394
Query: 200 TDPLLTPVEKASLRAMSLEEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKG 259
+ + E M +E KMRR E + E K RR++++ +K K+
Sbjct: 395 EEKMRRQEEM-----MWEKEEKMRRQE-----EMMWEKEEKMRRQEEMMWEKEEKI---R 441
Query: 260 KAKKALKEFEQLRKVNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEA 319
+ ++ + E E++R+ +E ++ E+ ++ E+ + Q + W + + I E
Sbjct: 442 ELEEKMHEQEKIRE-------QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR-----EQ 489
Query: 320 RQAMQEQLSKNKELTQKLQVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRS 379
+ ++EQ K +K+ + EEE E E + + E + W +
Sbjct: 490 EEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQE------EIWRQKE 543
Query: 380 CTSDTKEAAT-QEDPEQLPELEAHGVSESEGE--------ERPVAEEEILLREFEERRSL 430
+ +E QE+ E + H E E E + E+E +RE EE+ +
Sbjct: 544 KIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEK--I 601
Query: 431 RKRSELSQD-AEPAGSQETKDSGSQEVLSE----LRVLSQKLKENHQS-RKQKASSEGTI 484
R++ E++Q+ E G QE K +E + E +R +K++E + R+Q+
Sbjct: 602 REQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQE 661
Query: 485 PQVQREEPAPEEEEPLLLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQSER 540
+Q +E E+E + ++ E++Q EE +E+ ++ + R E Q +
Sbjct: 662 EMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQ 717
Score = 58.2 bits (139), Expect = 3e-08
Identities = 111/503 (22%), Positives = 204/503 (40%), Gaps = 58/503 (11%)
Query: 98 SSLATVKKQLSRVKSKKTVELPLNKEEIER--IHREVAFNKTAQVLSKWDPVVLKNRQAE 155
S++AT KK+ R + T E E+ R I E K A++ K V + + +
Sbjct: 243 SAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQ 302
Query: 156 QLVFPLEKEEPAIAPIEHVLSGWKARTPLEQEIFNLLHKNK--QPVTDPLLTPVEKASL- 212
V L+++ L K P +Q H K Q V+ L VE+ L
Sbjct: 303 LNVKELKRK----------LERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELW 352
Query: 213 -RAMSLEEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQL 271
R +E KM R E +Q + E +E+KI+ ++ + +++ + K +E
Sbjct: 353 NRLNQQQEEKMWRQE----EKIQEWEEKIQEQEEKIREQE--EKIREQEEKMRRQEEMMW 406
Query: 272 RKVNPAAALEEL--EKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSK 329
K EE+ EK EK R E M W K + I +LE + QE++ +
Sbjct: 407 EKEEKMRRQEEMMWEKEEKMRRQEEMM--------WEKEEKIR---ELEEKMHEQEKIRE 455
Query: 330 NKELTQ---KLQVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKE 386
+E Q K++ + +E+E EE + E ++ W + ++
Sbjct: 456 QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQ---EEKIREQEEKMWRQEEKIHEQEK 512
Query: 387 AATQEDPEQLPELEAHGVSESEGEE-----RPVAEEEILLREFEERRSLRKRSELSQDAE 441
+E ++ E+ E EE + E+E +R+ EE+ R+ ++ E
Sbjct: 513 IREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKM-WRQEEKMHDQEE 571
Query: 442 PAGSQETKDSGSQEVLSE----LRVLSQKLKENHQSRKQKASSEGTIPQ--VQREEPAPE 495
QE K +E + E +R +K++E + +++ G + ++EE E
Sbjct: 572 KIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQE 631
Query: 496 EEEPLLLQRP---ERVQTLEELEE--LGKEECFQNKELPRPVLEGQQSERTPNNRPDAPK 550
+EE + Q E+ + + E EE +EE Q +E E + E+ + K
Sbjct: 632 QEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEK 691
Query: 551 EKKKKEQMIDLQNLLTTQSPSVK 573
++++E+M + + L Q ++
Sbjct: 692 MRRQEEKMWEQEVRLRQQEEKMQ 714
Score = 57.4 bits (137), Expect = 5e-08
Identities = 107/540 (19%), Positives = 228/540 (42%), Gaps = 85/540 (15%)
Query: 3 ANRLAESLLALSQQEELADLPKDYLLSESEDEG---------DNDGERKHQKLLEAISSL 53
A L ++L A++ Q++ AD + L E + D + + K+ KL E + +
Sbjct: 235 AGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLV 294
Query: 54 DGKNRRKLAERSEASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSSLAT-VKKQLSRVKS 112
+ +E+SE L V E KL A LL P + + A + K+L V +
Sbjct: 295 E-------SEKSEIQLNVKELK-------RKLERAKLLLPQQQLQAEADHLGKELQSVSA 340
Query: 113 KKTVELP-------LNKEEIERIHREVAFNKTAQVLSKWDPVVL----KNRQAEQLVFPL 161
K ++ LN+++ E++ R+ + + +W+ + K R+ E+ +
Sbjct: 341 KLQAQVEENELWNRLNQQQEEKMWRQ------EEKIQEWEEKIQEQEEKIREQEEKI--- 391
Query: 162 EKEEPAIAPIEHVLSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAK 221
++E + E ++ W+ + ++ + K ++ + ++ +R + E K
Sbjct: 392 REQEEKMRRQEEMM--WEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIREL---EEK 446
Query: 222 MRRAELQRARALQSYYEAKARREKKIKS--KKYHKVVKKGKAKKALKEFEQLRKVNPAAA 279
M E R + E K + E+KI+ K+ + K + ++ ++E E+ +
Sbjct: 447 MHEQEKIREQ------EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKM 500
Query: 280 LEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDL-EARQAMQEQLSKNKELTQKLQ 338
+ EKI + + + + W + + I + ++ ++ + EQ K ++ +K+
Sbjct: 501 WRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMW 560
Query: 339 VASES--EEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQL 396
E ++EE E E++ + Q +R +E TQE E++
Sbjct: 561 RQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIRE-----QEEMTQEQEEKM 615
Query: 397 PELEAHGVSESEGEERPVAEEEILLREFEERRSLRKRSE-LSQDAEPAGSQETKDSGSQE 455
E +E + E+E ++E EE+ +R++ E + + + QE K +E
Sbjct: 616 GE-----------QEEKMCEQEEKMQEQEEK--MRRQEEKIREQEKKIREQEEKIREQEE 662
Query: 456 VLSEL--RVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLLQRPERVQTLEE 513
++ E ++ Q+ K Q K + E +++R+E E+E L Q+ E++Q +E
Sbjct: 663 MMQEQEEKMWEQEEKMCEQEEKMQEQEE----KMRRQEEKMWEQEVRLRQQEEKMQEHQE 718
Score = 48.9 bits (115), Expect = 2e-05
Identities = 78/450 (17%), Positives = 187/450 (41%), Gaps = 31/450 (6%)
Query: 171 IEHVLSGWKARTPLEQEIFNLLHKNKQP--VTDPLLTPVEKASLR----AMSLEEAKMRR 224
I + WK LEQ + + + K+ + L + SL ++ EE K +
Sbjct: 225 ISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKN 284
Query: 225 AELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELE 284
A+LQ L +++ + K +K + ++ E + L K + + +
Sbjct: 285 AKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQA 344
Query: 285 KIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASES- 343
++E+ + R++ + Q W + + I E + +QEQ K +E +K++ E
Sbjct: 345 QVEENELWNRLN-QQQEEKMWRQEEKIQ-----EWEEKIQEQEEKIREQEEKIREQEEKM 398
Query: 344 -EEEEGGTEDVEELLVPDVV---NEVQMNADGPNPWMLRSCTSDTKEAATQEDP---EQL 396
+EE E E++ + + E +M W + +E +++ ++
Sbjct: 399 RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEE 458
Query: 397 PELEAHGVSESEGEERPVAE---EEILLREFEERRSLRKRSELSQDAEPAGSQETKDSGS 453
E + E E + A+ +E +RE EE+ ++ Q+ + ++ ++
Sbjct: 459 KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEK 518
Query: 454 QEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLLQRPERVQTLEE 513
++ E+ +K++E + +QK +++++E +E + + E+++ EE
Sbjct: 519 RQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEE 578
Query: 514 ----LEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEK--KKKEQMIDLQNLLTT 567
EE +E+ + +E + E ++ + + +EK +++E+M + + +
Sbjct: 579 KVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRR 638
Query: 568 QSPSVKSLAVPTIEELEDEEERNHRQMIKE 597
Q ++ E ++E+ R +M++E
Sbjct: 639 QEEKIREQEKKIRE--QEEKIREQEEMMQE 666
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 61.2 bits (147), Expect = 3e-09
Identities = 154/747 (20%), Positives = 280/747 (37%), Gaps = 120/747 (16%)
Query: 13 LSQQEELADLPKDYLLSESEDEGDNDG----------ERKHQKLLEAI------------ 50
++ Q + D + ++ EGD++ ER+ ++L EA+
Sbjct: 68 VNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITD 127
Query: 51 SSLDGKNRRKLAERSEASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSSL----ATVKKQ 106
+SL +RR + A + +E SE E+ + + K+ A K+
Sbjct: 128 ASLSLPSRRM--QNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKK 185
Query: 107 LSRVKSKKTVELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEP 166
+ K ++ E P E + KT + + + LKN Q + EEP
Sbjct: 186 EDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQ-------ISSEEP 238
Query: 167 AIAPIEHVLSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAE 226
K EQ + H K D E+A L A E K + +
Sbjct: 239 ------------KQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDK 286
Query: 227 LQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEE--LE 284
+ E KA +++ + + + + + K+A +E +++++ AA E ++
Sbjct: 287 KIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIK 346
Query: 285 KIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESE 344
+ EK ER +K + K A + A+ + E + ++EQ +NK+L +K E++
Sbjct: 347 EEEKRAAEERQRIKEEE--KRAAEERQRARAEEEEKAKVEEQ-KRNKQLEEKKHAMQETK 403
Query: 345 EEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSD--TKEAATQED-PEQLPELEA 401
+ E VE+ + VNE + D +L+ + TK A +E E P +
Sbjct: 404 IKG---EKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKK 460
Query: 402 HGVSESEGEERPVAEEEILLREFEERRS-------------LRKRSELSQDAEPAGSQET 448
+ + + ++ +EE+ + F +R+ K G + +
Sbjct: 461 EEIKDEKIKKDKEPKEEV--KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRAS 518
Query: 449 KDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLLQRPERV 508
D+ +E +V + K E + R+ + SE Q+++ A E E L +R ER
Sbjct: 519 VDT--KEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERR 576
Query: 509 QTLEELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMIDLQNLLTTQ 568
+ LEE E+ K+E E R + E ++ R E +K Q + L +
Sbjct: 577 KVLEEEEQRRKQE-----EADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDK 631
Query: 569 SPSVKSLAVPTIEELEDEEERNHRQMIKEA-------FAGDDVIRDFLKEKREAVEA--- 618
P + ++E+ E ++ + K + A I L++ A+E
Sbjct: 632 KPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKS 691
Query: 619 ---SKPKDVDLTLPGWG--------EWGGV---------------GLKPSAKKR-RRFLI 651
+KP DL +P G E G V GLK R +L
Sbjct: 692 AKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLT 751
Query: 652 KAPEG---PPRKDKNLPNVIINEKRNI 675
K P+G P K +L ++ KRN+
Sbjct: 752 KTPDGNKSPAPKPSDLRPGDVSSKRNL 778
Score = 53.9 bits (128), Expect = 5e-07
Identities = 90/470 (19%), Positives = 188/470 (40%), Gaps = 71/470 (15%)
Query: 191 LLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAELQ-RARALQSYYEAKARREKKIKS 249
L K ++ + VE + ++ EEAK Q ++ E ARRE++
Sbjct: 50 LRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREER--- 106
Query: 250 KKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSK 309
+ K+ + E+ ++ +P L +R M+ + +++ + K KS+
Sbjct: 107 ----------RQKRLQEALERQKEFDPTITDASLSL--PSRRMQNDTAENETTEKEEKSE 154
Query: 310 AIMAKYDLEARQAMQEQLSKNK----ELTQKLQVASESEEEEGGT-----EDVEELLVPD 360
+ +Y++E + + + KN E +K E EEEE E+ E++V +
Sbjct: 155 SRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEE 214
Query: 361 VVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQ-LPELEAHGVSESEGEERPVAE--- 416
E Q + L++ ++E +E+ EQ E+ H E E +ER AE
Sbjct: 215 KTTESQ---EETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERAR 271
Query: 417 --------------------------EEILLREFEERRSLRKRSELSQDAEPAGSQETKD 450
EE + ERR +R + ++ + A + +
Sbjct: 272 LEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRI 331
Query: 451 SGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLLQRPERVQT 510
++ +E R ++ ++ +Q+ E +R+ EEEE ++ +R +
Sbjct: 332 KEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQ 391
Query: 511 LEELEELGKEECFQNKELPRPVLEGQ---QSERTPNNRPDAPKEKKKKEQMIDLQ---NL 564
LEE + +E + +++ + + EG+ + + + A +K+ +E+ +Q
Sbjct: 392 LEEKKHAMQETKIKGEKVEQKI-EGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREK 450
Query: 565 LTTQSPSVKSLAVPTIEELEDEEERNHRQMIKEAFAGDDVIRDFLKEKRE 614
L P+ K EE++DE+ + ++ +E + D + F + K +
Sbjct: 451 LQEDKPTFKK------EEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ 494
>gi|45439327 periplakin [Homo sapiens]
Length = 1756
Score = 60.5 bits (145), Expect = 6e-09
Identities = 113/548 (20%), Positives = 225/548 (41%), Gaps = 106/548 (19%)
Query: 6 LAESLLALSQQ-----EELADLPKDYLLSE----SEDEGDNDGERKHQKLLEAISSLDGK 56
L E L AL Q +E D ++Y++ E D D ++L+ L+
Sbjct: 967 LQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQAD------EVLQLREELEAL 1020
Query: 57 NRRKLAERSEASL---KVSEFNVSSEGSGEKLVLADLLEPVKTSSSLATVKKQLS----- 108
R+K A +E L +V+ + EK+ ++++ ++ L +QL
Sbjct: 1021 RRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVK-LQNDPQLEAEYQQLQEDHQR 1079
Query: 109 --RVKSKKTVELPLNKEEIERIHREVAFNK---TAQVLSKWDPVVLKNRQAEQLVFPLEK 163
+++ K+ EL +++++R+ +E A + T + + K + R+ L E
Sbjct: 1080 QDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYED 1139
Query: 164 EEPAIAPIEHVLSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPV---------EKASLRA 214
E + + +T L ++I+ L +N + V + + E A+LR
Sbjct: 1140 EAAKARASQ------REKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRL 1193
Query: 215 MSLEEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKAL-KEFEQLRK 273
+E+ + R ++ R+ QS EA RR +++ K+ K V K K + KE ++LR+
Sbjct: 1194 ELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLRE 1253
Query: 274 VNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKEL 333
E ++K R++ER L+ K +++A + + Q+ + KE+
Sbjct: 1254 ----------EIVDKTRLIERCDLE-----------IYQLKKEIQALKDTKPQV-QTKEV 1291
Query: 334 TQKLQVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQEDP 393
Q++ E + + + L + +V + +E A+QE+
Sbjct: 1292 VQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLE----------------RERASQEEQ 1335
Query: 394 EQLPELEAHGVSESEGEERPVAEEEILLREFEERRSLRKRSELSQDAEPAGSQETKDSGS 453
E E V E V ++E++ +EE LR AE + E+ D
Sbjct: 1336 IARKEEELSRVKER------VVQQEVV--RYEEEPGLR--------AEASAFAESIDV-- 1377
Query: 454 QEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLLQRPERVQTLEE 513
ELR + + E + ++++ E + +++RE A E E + + +R+ LE+
Sbjct: 1378 -----ELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQ 1432
Query: 514 LEELGKEE 521
E +E+
Sbjct: 1433 EEAEAREK 1440
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 59.3 bits (142), Expect = 1e-08
Identities = 137/649 (21%), Positives = 254/649 (39%), Gaps = 79/649 (12%)
Query: 34 EGDNDGERKHQKLLEAISSLDGKNRRKLAERSEASLKVSEFNV----------SSEGSGE 83
+G D E K +K+ + L K R+E + KV++ V S+
Sbjct: 1238 QGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSS 1297
Query: 84 KLV--LADLLEPVKTSSSLATV--KKQLSRVKSKKTVELPLN--KEEIERIHREVAFNKT 137
KL + L ++ + L +++LS K VE N +E++E E N
Sbjct: 1298 KLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEE-EEEAKHNLE 1356
Query: 138 AQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVLSGWKARTPLEQEIFNLLHKNK- 196
Q+ + V ++ E V LE E ++ L G R + ++ L K K
Sbjct: 1357 KQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKT 1416
Query: 197 --QPVTDPLLTPVEKASLRAMSLEEAKMRRAEL--QRARALQSYYEAKARREKKIKSKKY 252
Q D LL ++ A +LE+ + + +L + Y E + R E + + K+
Sbjct: 1417 RLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKE- 1475
Query: 253 HKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERMSLKH---QNSGKWAKSK 309
K +AL+E + A LE L K + M + MS K ++ + KSK
Sbjct: 1476 ---TKALSLARALEE-----AMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSK 1527
Query: 310 AIMAKYDLEAR---QAMQEQLSKNKELTQKLQV-----ASESEEEEGGTEDVEELLVPDV 361
+ + E + + ++++L ++ +L+V ++ E + G ++ E +
Sbjct: 1528 RALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQL 1587
Query: 362 VNEV-QMNADGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGVSESEGEERPV------ 414
V +V +M A+ + RS AA ++ L +LEAH S ++ + +
Sbjct: 1588 VRQVREMEAELEDERKQRSMA----VAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKL 1643
Query: 415 -AEEEILLREFEERRSLRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQS 473
A+ + +RE ++ R+ R+ L+Q E ++ ++ ++ EL + ++ Q
Sbjct: 1644 QAQMKDCMRELDDTRASREEI-LAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQE 1702
Query: 474 RKQKASSEGTIPQVQREEPAPEEEEPLLLQRPERVQTLEELEELGKEECFQNKELPRPVL 533
R + A I + EE+ L R +++ EELEE N L + L
Sbjct: 1703 RDELADE---IANSSGKGALALEEKRRLEARIAQLE--EELEEEQGNTELINDRLKKANL 1757
Query: 534 EGQQ---------SERTPNNRPDAPKEKKKKEQMIDLQNLLTTQSPSVKS------LAVP 578
+ Q S N E++ KE + LQ + T K+ +
Sbjct: 1758 QIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIA 1817
Query: 579 TIEELEDEEERNHRQMIKEAFAGDDVIRDFL----KEKREAVEASKPKD 623
+EE D E + + K+ + ++D L E+R A + D
Sbjct: 1818 QLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQAD 1866
Score = 43.5 bits (101), Expect = 7e-04
Identities = 119/607 (19%), Positives = 227/607 (37%), Gaps = 104/607 (17%)
Query: 111 KSKKTVELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAP 170
K K +++ +EE+ E+ + Q+ ++ ++ Q++ + L+ +E A
Sbjct: 833 KVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAE 892
Query: 171 IEHVLSGWKARTPL---EQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRR--A 225
E + R L +QE+ + H + V + E+ + + E+ KM++
Sbjct: 893 TELCAEAEELRARLTAKKQELEEICHDLEARVEE------EEERCQHLQAEKKKMQQNIQ 946
Query: 226 ELQRA-----RALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAAL 280
EL+ A Q K E K+K + +++ + + K KE + L
Sbjct: 947 ELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTT 1006
Query: 281 EELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQ----- 335
E+ EK++ + ++ KH+ A++ DLE R +E+ + E T+
Sbjct: 1007 NLTEEEEKSKSLAKLKNKHE---------AMIT--DLEERLRREEKQRQELEKTRRKLEG 1055
Query: 336 -------------------KLQVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWM 376
K+Q+A + EE + VEE Q N
Sbjct: 1056 DSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEE-------EAAQKNMALKKIRE 1108
Query: 377 LRSCTSDTKE----------AATQEDPEQLPELEAHGVSESEGEERPVAEEEILLREFEE 426
L S S+ +E A ++ + ELEA + + A++E+ + +E
Sbjct: 1109 LESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQE 1168
Query: 427 RRSLRKRSELSQDAEPAGSQETKDSGSQ--EVLSELRVLSQKLKENHQSRKQKASSE--- 481
L+K E A QE + SQ E L+E ++++K N + KQ +E
Sbjct: 1169 VNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGE 1228
Query: 482 ------------GTIPQVQREEPAPEEEEPLLLQRPERVQTLEELEELGKEECFQNKELP 529
G +++ A +E + ERV+T EL + EL
Sbjct: 1229 LANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRT-----ELADKVTKLQVELD 1283
Query: 530 RPVLEGQQSERTPNNRPDAPKEKKKKEQMIDLQNLLTTQSPSVKSLAVPTIEELEDEEER 589
+ G S+ + + Q+ D Q LL ++ SL+ ++++EDE+
Sbjct: 1284 N--VTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLST-KLKQVEDEKNS 1340
Query: 590 NHRQMIKEAFAGDDVIRDFLKEKREAVEASKPKDVDLTLPGWGEWGGVGLKPSAKKRRRF 649
Q+ +E A ++ + + + K + VG +A++ +R
Sbjct: 1341 FREQLEEEEEAKHNLEKQIATLHAQVADMKKKME-----------DSVGCLETAEEVKRK 1389
Query: 650 LIKAPEG 656
L K EG
Sbjct: 1390 LQKDLEG 1396
Score = 40.8 bits (94), Expect = 0.005
Identities = 108/528 (20%), Positives = 209/528 (39%), Gaps = 68/528 (12%)
Query: 16 QEELADLPKDYLLSESEDEGDNDGERKHQKLLEAISSLDGKNRRKLAERSEASLKVSEFN 75
Q+EL DL D ++K +LL ++ K + +R+EA + E
Sbjct: 1419 QQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEE-RDRAEAEAREKETK 1477
Query: 76 VSSEGSGEKLVLADLLEPVKTSSSLATVKKQLSRVKSKKTVELPLNKEEIERIHREVAFN 135
S + L E ++ + L + KQ + +L +K+++ + E+ +
Sbjct: 1478 ALS-------LARALEEAMEQKAELERLNKQFRT----EMEDLMSSKDDVGKSVHELEKS 1526
Query: 136 KTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVLSGWKARTPLEQEIFNLLHKN 195
K A V Q E+L L+ E A +E L KA+ E+++ ++
Sbjct: 1527 KRALE----QQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQ--FERDLQGRDEQS 1580
Query: 196 KQPVTDPLLTPVEKASLRAMSLEEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKV 255
++ +K +R + EA++ QR+ A+ A+ + E +K + H
Sbjct: 1581 EEK---------KKQLVRQVREMEAELEDERKQRSMAVA----ARKKLEMDLKDLEAHID 1627
Query: 256 VKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKY 315
+A+K+ +L+ + EL+ +R E ++ +N K +A M +
Sbjct: 1628 SANKNRDEAIKQLRKLQ-AQMKDCMRELDDTRASRE-EILAQAKENEKKLKSMEAEMIQL 1685
Query: 316 DLEA-------RQAMQEQ-----------------LSKNKELTQKL-QVASESEEEEGGT 350
E RQA QE+ L + + L ++ Q+ E EEE+G T
Sbjct: 1686 QEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNT 1745
Query: 351 EDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGVSESEGE 410
E + + L + Q+N D L + E A Q+ Q EL+ + E EG
Sbjct: 1746 ELINDRLKKANLQIDQINTD----LNLERSHAQKNENARQQLERQNKELKVK-LQEMEGT 1800
Query: 411 ERPVAEEEILLREFEERRSLRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKEN 470
+ + I E + + + +++ + A Q + +++ L ++ + + N
Sbjct: 1801 VKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRR---TEKKLKDVLLQVDDERRN 1857
Query: 471 HQSRKQKASSEGT-IPQVQRE-EPAPEEEEPLLLQRPERVQTLEELEE 516
+ K +A T + Q++R+ E A EE + R + + LE+ E
Sbjct: 1858 AEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATE 1905
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 59.3 bits (142), Expect = 1e-08
Identities = 106/491 (21%), Positives = 207/491 (42%), Gaps = 70/491 (14%)
Query: 31 SEDEGDNDGERKHQKLL--------EAISSLDGKNRRKLAERSEASLKVSEFNVSSEGSG 82
SE++ DN + K + + E+ L + +K ++++ + N + S
Sbjct: 164 SEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASF 223
Query: 83 EKLVLADLLEPVKTSSSLATVKKQLSRVK---SKKTVELPLNKEEIERIHREVAFNKTAQ 139
+ +KT + KK+ R K K + KEE+E ++ + K +Q
Sbjct: 224 K----------IKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQ 273
Query: 140 VLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPI--EHVLSGWKARTPLEQEIFNLLHKNKQ 197
K++ +K++ EE A P E G K + +++ K K+
Sbjct: 274 --RKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKE 331
Query: 198 PVTDPLLTPVE--KASLRAMSLEEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKV 255
P V+ + +L + EE + +R E +R + L+ EAK + E++++ +K +
Sbjct: 332 KKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEEL-EAKRKEEERLEQEKRERK 390
Query: 256 VKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAK- 314
+K K +K E+L+K L + ++ +AR + L Q G SK + K
Sbjct: 391 KQKEKERK-----ERLKK--EGKLLTKSQREARARAEATLKLL-QAQGVEVPSKDSLPKK 442
Query: 315 ---YDLEARQAMQEQLSKNKELTQKLQVASESEEEEGGTEDVEELLVPDVVNEVQMNAD- 370
Y+ + R+ + +QL ++KE+++ +++ + E E G + EE P E + D
Sbjct: 443 RPIYEDKKRKKIPQQL-ESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDA 501
Query: 371 GPNPWMLRSCTSDTK---------------------EAATQEDPEQLPELEAHGVSESEG 409
G + W + +T+ E +ED E E E G ESEG
Sbjct: 502 GLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEG--ESEG 559
Query: 410 EERPVAEEEILLREFEERRSLRKR--SELSQDAE-PAGSQETKDSGSQEVLSELRVLSQK 466
E E+E + E + ++L K+ E+S D+E + TK+ + + ++ R+ ++
Sbjct: 560 SEGD-EEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYD-KAKRRIEKRR 617
Query: 467 LKENHQSRKQK 477
L+ + +K
Sbjct: 618 LEHSKNVNTEK 628
Score = 52.8 bits (125), Expect = 1e-06
Identities = 87/442 (19%), Positives = 178/442 (40%), Gaps = 46/442 (10%)
Query: 201 DPLLTPVEKASLRAMSLEEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGK 260
D +L +E+ SL A ++ + E + ++ E ++KK K +K K
Sbjct: 56 DDILKELEELSLEAQGIKADR----ETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDN 111
Query: 261 AKKALKEFEQLRKVNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEAR 320
+ L++ + K +E + ++ K + GK KS K+D
Sbjct: 112 DSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAK--GKAQKSNK---KWD---- 162
Query: 321 QAMQEQLSKNKELTQKLQVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSC 380
+E +K++ ++ ++ S E G E E L + Q N GPN
Sbjct: 163 -GSEEDEDNSKKIKERSRINSSGES---GDESDEFLQSRKGQKKNQKNKPGPNI------ 212
Query: 381 TSDTKEAATQEDPE--QLPELEAHGVSESEGEERPVAEEEILLREFEERRSL-------- 430
E+ ++D ++ + + E E + EE+ LR+ +E+ L
Sbjct: 213 -----ESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQS 267
Query: 431 -RKRSELSQDAEPAGSQETKDSG---SQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQ 486
+K S+ + E S+ T D+G + E +E ++ E + +K K +G +
Sbjct: 268 KQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEE 327
Query: 487 VQREEPAPEEEEPLLLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQSERTPNNRP 546
++E+ + + + + EE E +EE + K L + ++ ER +
Sbjct: 328 KEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKR 387
Query: 547 DAPKEKKK--KEQMIDLQNLLTTQSPSVKSLAVPTIEELEDE--EERNHRQMIKEAFAGD 602
+ K+K+K KE++ LLT ++ A T++ L+ + E + + K+ +
Sbjct: 388 ERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYE 447
Query: 603 DVIRDFLKEKREAVEASKPKDV 624
D R + ++ E+ E S+ ++
Sbjct: 448 DKKRKKIPQQLESKEVSESMEL 469
Score = 35.0 bits (79), Expect = 0.26
Identities = 71/342 (20%), Positives = 144/342 (42%), Gaps = 31/342 (9%)
Query: 30 ESEDEGDNDGERKHQKLLEAISSLDGKNRRKLAERSEASLKVSEFNVSSEGSGEKLVLAD 89
E E + ++ + K +KL E GK + +++ E+ K E V S+ + + V+
Sbjct: 237 ERERKKRDEEKAKLRKLKEKEELETGKKDQ--SKQKESQRKFEEETVKSKVTVDTGVIPA 294
Query: 90 LLEPVKTSSSLATVKKQLSRVKSKKTVELPLNKEEIERIHREVAFNKTAQVLSKWDPVVL 149
E +T ++ + + K KK + KEE E+ ++ T + + + +
Sbjct: 295 SEEKAETPTAAEDDNEGDKKKKDKKKKKG--EKEEKEKEKKKGPSKATVKAMQE---ALA 349
Query: 150 KNRQAEQLVFPLEKEEPAIAPIEHVLSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPVEK 209
K ++ E+ +EE I +E + + K LEQE + KQ + ++
Sbjct: 350 KLKEEEER--QKREEEERIKRLEELEAKRKEEERLEQE---KRERKKQKEKERKERLKKE 404
Query: 210 ASLRAMSLEEAKMRRA---ELQRARALQ-----------SYYEAKARRE--KKIKSKKYH 253
L S EA+ R +L +A+ ++ YE K R++ ++++SK+
Sbjct: 405 GKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVS 464
Query: 254 KVVKKGKAKKALKE-FEQLRKVNPAAALEELEKIEKARM--MERMSLKHQNSGKWAKSKA 310
+ ++ A + +++ + + P EE E E A + E M+ +
Sbjct: 465 ESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVH 524
Query: 311 IMAKYDLEARQAMQEQLSKNKELTQKLQVASESEEEEGGTED 352
I K + E + +E+ +++E ++ + ESE EG ED
Sbjct: 525 IEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEED 566
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 57.8 bits (138), Expect = 4e-08
Identities = 128/645 (19%), Positives = 261/645 (40%), Gaps = 81/645 (12%)
Query: 4 NRLAESLLALSQQEELADLPKDYLLSESEDEGDNDGERKHQKLLEAISSLDGKNRRKLAE 63
+ LA SL QQ E ++ L + +++E +R ++ +A+ DG R+ E
Sbjct: 606 SNLAHSLQVAQQQAEELRQEREKLQA-AQEELRRQRDRLEEEQEDAVQ--DGARVRRELE 662
Query: 64 RSEASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSSLATVKKQLSRVKSKKTVELPLNKE 123
RS L+ E G++ VLA L V+ + S AT+++ + + + + E L K
Sbjct: 663 RSHRQLEQLE--------GKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEA-LTKA 713
Query: 124 EIERIHREVAFNKT-AQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVLSGWKART 182
E R+ E++ K A+ S D + + E L + L +
Sbjct: 714 EAGRVELELSMTKLRAEEASLQDSLSKLSALNESLA-------------QDKLDLNRLVA 760
Query: 183 PLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAELQRARALQSYYEAKAR 242
LE+E L + +Q + + E+ L + LE+ R+ R + EA +
Sbjct: 761 QLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQ 820
Query: 243 REKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERMSLKHQNS 302
+ ++ ++ + + + L EQ + A ++E +E+A E+ +L +++
Sbjct: 821 QLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERA-AREKEALAKEHA 879
Query: 303 GKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESEEEEGGTEDVEELLVPDVV 362
G + A A +E + ++E T ++ E E EG +V+ L
Sbjct: 880 GLAVQLVA-----------AEREGRTLSEEAT---RLRLEKEALEGSLFEVQRQLAQLEA 925
Query: 363 NEVQMNADGPNPWMLRSCTSD------TKEAATQEDPEQLPELEAHGVSESEGEERPVAE 416
Q+ A+G + + + + ATQE EL A + ++E E +
Sbjct: 926 RREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLR 985
Query: 417 EEILLREFEERRSLRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQ 476
E+ E + +R R++ ++ E +Q + S+L+ ++L ++ K+
Sbjct: 986 EQRAAHEEDLQRLQREKEAAWRELEAERAQ---------LQSQLQREQEELLARLEAEKE 1036
Query: 477 KASSEGTIPQVQREE----PAPEEEEPLLLQRPERVQTLEELEELGKEECFQNKELPRPV 532
+ S E Q +R+E E+++ L L+ E+ E+L +G L
Sbjct: 1037 ELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKL--MGTRHSLATISLE--- 1091
Query: 533 LEGQQSERTPNNRPDAPKEKKKKEQMIDLQNLLTTQSPSVKSLAVPTIEE---------- 582
+E Q+ + D ++ DL+ ++ + + V ++E
Sbjct: 1092 MERQKRDAQSRQEQDRSTVNALTSELRDLR-AQREEAAAAHAQEVRRLQEQARDLGKQRD 1150
Query: 583 ---LEDEEERNHRQMIKEAFAGDDVIRDFLKEKREAVEASKPKDV 624
E EE R +++++ A D + R+ L+ +R+ E+ + ++V
Sbjct: 1151 SCLREAEELRTQLRLLED--ARDGLRRELLEAQRKLRESQEGREV 1193
Score = 47.8 bits (112), Expect = 4e-05
Identities = 96/454 (21%), Positives = 186/454 (40%), Gaps = 62/454 (13%)
Query: 153 QAEQLVFPLEKEEPAIAPIEHVLSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPVEKASL 212
+A QL + + E A ++ LSG +A L++E + ++ D + T + SL
Sbjct: 1552 RARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATL--ERSL 1609
Query: 213 RAMSLEEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLR 272
+A E + + ++ + +A ++ E RR K++ + VK +++L+
Sbjct: 1610 QATE-SELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEG----- 1663
Query: 273 KVNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNK- 331
EL++ R+ L S + A+++A+ + D RQ ++
Sbjct: 1664 ---------ELQR-------SRLGL----SDREAQAQALQDRVDSLQRQVADSEVKAGTL 1703
Query: 332 ELT-QKLQVA-SESEEEEGGTED-VEELLVPDVVNEVQMNADGPNPWMLR----SCTSDT 384
+LT ++L A ++ EE EG D V L + +N+ L+ +C D
Sbjct: 1704 QLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDR 1763
Query: 385 KEAATQEDPEQLPELEAHGVSESEGEERPVAEEEILLREFE------ERRSLRKRSELSQ 438
+ + D + EA S S GE+ E+ E + + + LR+ Q
Sbjct: 1764 QVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQ 1823
Query: 439 DAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEE 498
+ E A Q++ E R+L ++L S + + Q++ E+ E E
Sbjct: 1824 EGEAAALNTV-----QKLQDERRLLQERL----------GSLQRALAQLEAEKR--EVER 1866
Query: 499 PLLLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQM 558
L +RV L+++ +E+ +++ R E + +RT E +++ Q
Sbjct: 1867 SALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQ 1926
Query: 559 IDLQNLLTTQSPSVKSLAVPTIE---ELEDEEER 589
++ Q ++ QS S L V + EL+ E ER
Sbjct: 1927 LEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVER 1960
Score = 39.7 bits (91), Expect = 0.011
Identities = 62/277 (22%), Positives = 117/277 (42%), Gaps = 50/277 (18%)
Query: 293 ERMSLKHQNSGKWAKSKAIM-----AKYDLEARQAMQEQLSKNKE-LTQKLQVASESEEE 346
ER +L+ Q K+ M A+ +++ ++ E LS+ K L LQVA + EE
Sbjct: 562 ERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEE 621
Query: 347 EGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQLPELEA--HGV 404
++ E+L E++ D + +E A Q+ ELE +
Sbjct: 622 L--RQEREKLQAAQ--EELRRQRDR---------LEEEQEDAVQDGARVRRELERSHRQL 668
Query: 405 SESEGEERPVAEEEILLREFEERRSLRKRSELSQDAEPAGSQETKDSGS----------- 453
+ EG+ +A+E + +RE R +L++ ++ AE A + ++G
Sbjct: 669 EQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLR 728
Query: 454 ------QEVLSELRVLSQKLKENH--------QSRKQKASSEGTIPQVQREEPAPEEEEP 499
Q+ LS+L L++ L ++ Q ++K++ +G Q ++E EE+
Sbjct: 729 AEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQ- 787
Query: 500 LLLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQ 536
+R E ++ +E+ G E + E + LE Q
Sbjct: 788 ---ERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQ 821
Score = 36.2 bits (82), Expect = 0.12
Identities = 94/390 (24%), Positives = 154/390 (39%), Gaps = 61/390 (15%)
Query: 62 AERSEASLKVSEFNVSSEGSGEKLVLADLLEP----VKTSSSLATVKKQLSRVKSKKTVE 117
AE+ E S +++ + E L+LA+ + +K S A +K + S T+
Sbjct: 1033 AEKEELSEEIAALQQERD---EGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATIS 1089
Query: 118 LPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVLSG 177
L + +++ + R+ T L+ L++ +A+ +EE A A + V
Sbjct: 1090 LEMERQKRDAQSRQEQDRSTVNALTS----ELRDLRAQ-------REEAAAAHAQEVRR- 1137
Query: 178 WKARTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAK--MRRAELQRARALQS 235
L+++ +L KQ D L E+ + LE+A+ +RR L+ R L+
Sbjct: 1138 ------LQEQARDL---GKQ--RDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRE 1186
Query: 236 YYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERM 295
E R ++ ++ + + + +G KE E LR+ N EEL K ER+
Sbjct: 1187 SQEG--REVQRQEAGELRRSLGEGA-----KEREALRRSN-----EELRSAVKKAESERI 1234
Query: 296 SLKHQNSGKWAK------SKAIMAKYDLEARQAMQEQLSKNKELTQKLQVAS------ES 343
SLK N K K ++ + K E R +QE E ++LQ +S
Sbjct: 1235 SLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDS 1294
Query: 344 EEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHG 403
E G E + EL + E LR K A+ E Q ++
Sbjct: 1295 ENTRLGRE-LAELQGRLALGERAEKESRRETLGLRQRL--LKGEASLEVMRQELQVAQRK 1351
Query: 404 VSESEGEERPVAEEEILLREFEERRSLRKR 433
+ E EGE R E LL EE R K+
Sbjct: 1352 LQEQEGEFR--TRERRLLGSLEEARGTEKQ 1379
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 57.8 bits (138), Expect = 4e-08
Identities = 109/449 (24%), Positives = 191/449 (42%), Gaps = 61/449 (13%)
Query: 215 MSLEEAKMRRAELQRARALQSYYEAKARRE---KKIKSKKYHKVVKKGKAKKALKEFE-Q 270
+++E A+++R + Q+ E + R ++++S+ KV + ++ L+E E +
Sbjct: 619 LTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGE 678
Query: 271 LRKVNPAAALEELEKIEKAR---------MMERMSLKHQNSGKWAKSK----------AI 311
LRK LEEL +++ R + +++S H +S+ +
Sbjct: 679 LRK-----NLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELL 733
Query: 312 MAKYDLE----ARQAMQEQLSKN-KELTQ-----KLQVASESEEEEGGTE--DVEELLVP 359
AK DL+ A++ ++ L K +ELT K +V+S +E + E D E +
Sbjct: 734 QAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALR 793
Query: 360 DVVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGVSESEGEERPVAE--- 416
+ V E N + RS TS+ +A T+ + L E SE ER VA+
Sbjct: 794 ESVEEATKNVE---VLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQR 850
Query: 417 --EEILLREFEERRSLRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSR 474
E++ E + + +L+K + E A K+ +E +S R L EN
Sbjct: 851 QIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEE--KEAVSARRAL-----ENELEA 903
Query: 475 KQKASSEGTIPQVQREEPAPEEEEPLLLQRPERVQTLEELEELGKEECFQNKELPRPVLE 534
Q S+ T Q Q E EE E R + + E LGK KE+ V
Sbjct: 904 AQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEA 963
Query: 535 GQQSERTPNNRPDAPKEKKKKEQMIDLQNLL---TTQSPSVKSLAVPTIEE--LEDEEER 589
+ S N+ D KEK ++E + ++Q L T ++ + A+ +E L +EE R
Sbjct: 964 SRTSTLELQNQLDEYKEKNRRE-LAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELR 1022
Query: 590 NHRQMIKEAFAGDDVIRDFLKEKREAVEA 618
++++ EA ++ LK+ +EA
Sbjct: 1023 DYQRAQDEALTKRQLLEQTLKDLEYELEA 1051
Score = 54.7 bits (130), Expect = 3e-07
Identities = 146/653 (22%), Positives = 258/653 (39%), Gaps = 137/653 (20%)
Query: 13 LSQQ--EELADLPKDYLLSESEDEGDNDGERKHQKLLEAISSLDGKNRRKLAERSEASLK 70
L+QQ EE A L E + D+ +RK + E I +L + ++A
Sbjct: 546 LTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNS 605
Query: 71 VSEFNVSSEGSGEKLVLADLLEPV-KTSSSLATVKKQLS-RVKSKKTVELPLNKEEIERI 128
SE + DLLE K + +A +++QL VK+++ + KEE ER+
Sbjct: 606 TSE-------------VKDLLEQKSKLTIEVAELQRQLQLEVKNQQNI-----KEERERM 647
Query: 129 HREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVLSGWKARTPLEQEI 188
+ ++ S+ + V +N +Q LE+ E + L K Q
Sbjct: 648 RANLE-----ELRSQHNEKVEENSTLQQR---LEESEGELRKNLEELFQVKMEREQHQTE 699
Query: 189 FNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAELQRARALQSYYEAKARREKKIK 248
L + D L ++ R+ E+ + LQ + LQ AK +E ++
Sbjct: 700 IRDLQDQLSEMHDEL-----DSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLR 754
Query: 249 SKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERMSLKHQNSGKWAKS 308
++ KG K+ + +Q E++K+++
Sbjct: 755 KRERELTALKGALKEEVSSHDQ-----------EMDKLKE-------------------- 783
Query: 309 KAIMAKYDLEARQAMQEQLSKNKELTQKLQV----ASESEEEEGGTEDVEELLVPDVVNE 364
+YD E QA++E + +E T+ ++V ++ SE+++ GTE +LL + NE
Sbjct: 784 -----QYDAEL-QALRESV---EEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEE--NE 832
Query: 365 VQMNADGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHG---VSESEGEERPVAEEEILL 421
RS + + A Q E L EA + + EGE R + E +
Sbjct: 833 KLQG---------RSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHA 883
Query: 422 REFEERRSLRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSE 481
R+ EE+ ++ R L + E A ++ + Q+ LSE L ++ ++ Q R+ K E
Sbjct: 884 RK-EEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEK--LKEESEQKEQLRRLKNEME 940
Query: 482 G-------TIPQVQREEPAPEEEEPLLLQRPERVQTLEELEELGKEECFQ-NKELPRPVL 533
TI ++Q+E + E E L+E +E + E + ++L L
Sbjct: 941 NERWHLGKTIEKLQKE--MADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTL 998
Query: 534 EGQQSERTPNNRPD--------------APKEKKKKEQMI-----DLQNLLTTQS--PSV 572
E ++S T D A E K Q++ DL+ L +S
Sbjct: 999 EAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDD 1058
Query: 573 KSLAVPTIE------ELEDEEERNHRQMIKEAFAGD----DVIRDFLKEKREA 615
+S V +E E+E EEERN+ ++ E + + +R+ L ++R A
Sbjct: 1059 RSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAA 1111
Score = 34.7 bits (78), Expect = 0.34
Identities = 71/382 (18%), Positives = 161/382 (42%), Gaps = 31/382 (8%)
Query: 5 RLAESLLALSQQEELADLPKDYLLSESED-EGDNDGERKHQKLLEAISSLDGKNRRKLAE 63
+L E+L+ ++E+ A + L +E E +G+ + QK L + + + +L
Sbjct: 875 QLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQL-R 933
Query: 64 RSEASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSSLATVKKQLSRVKSKKTVELPLNKE 123
R + ++ +++ + +AD++E +TS+ ++ QL K K EL +
Sbjct: 934 RLKNEMENERWHLGKTIEKLQKEMADIVEASRTST--LELQNQLDEYKEKNRRELAEMQR 991
Query: 124 EIERIHREVAFNKTAQVLSKWDPVVLKN------RQAEQLVFPLEKEEPAIAPIEHVLSG 177
+++ E ++ + + + +++ R ++ + + E + +E+ L
Sbjct: 992 QLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYEL-- 1049
Query: 178 WKARTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAM-------SLEEAKMRRAELQRA 230
+A++ L+ + L+ + + V+ + E+ + + S E+ + R EL +
Sbjct: 1050 -EAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQE 1108
Query: 231 RALQSYYEAKA----RREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKI 286
RA + E R+ K +KS+ H +K+ L V A + ELE
Sbjct: 1109 RAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLV-------VQMEARIAELEDR 1161
Query: 287 EKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESEEE 346
++ +R +L+ N K K ++ + D E ++ + L + E+EEE
Sbjct: 1162 LESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEE 1221
Query: 347 EGGTEDVEELLVPDVVNEVQMN 368
E ++ L ++ ++ MN
Sbjct: 1222 IDRLESSKKKLQRELEEQMDMN 1243
Score = 33.1 bits (74), Expect = 1.0
Identities = 59/312 (18%), Positives = 122/312 (39%), Gaps = 45/312 (14%)
Query: 321 QAMQEQLSKNKELTQKLQVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSC 380
Q+ +E+ K T LQ + + + G + + P N P +L+
Sbjct: 490 QSKKEEEVKTATATLMLQNRATATSPDSGAKKISVKTFPSASNTQA------TPDLLKG- 542
Query: 381 TSDTKEAATQEDPEQLPELEAHGVSESEGEERPVAEEEILLREFEERRSLRKRSELSQDA 440
+E Q + E ++ + + E + + ++ L FE+ ++L+ R+
Sbjct: 543 ---QQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNL-VFEKIQTLKSRA------ 592
Query: 441 EPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPL 500
AGS + + +L QK K + + ++QR+ + +
Sbjct: 593 --AGSAQGNNQACNSTSEVKDLLEQKSKLTIE-----------VAELQRQLQLEVKNQQN 639
Query: 501 LLQRPERVQT-LEELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQ-- 557
+ + ER++ LEEL E+ +N L + + E + R N + + K ++EQ
Sbjct: 640 IKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELR--KNLEELFQVKMEREQHQ 697
Query: 558 --MIDLQNLLTTQSPSVKSLAVPTIEELEDEEERNHRQMIKEAFAGDDVIRDFLKEKREA 615
+ DLQ+ L+ + S + E+R +I+E ++D L K E
Sbjct: 698 TEIRDLQDQLSEMHDELDSA--------KRSEDREKGALIEELLQAKQDLQDLLIAKEEQ 749
Query: 616 VEASKPKDVDLT 627
+ + ++ +LT
Sbjct: 750 EDLLRKRERELT 761
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 57.4 bits (137), Expect = 5e-08
Identities = 154/737 (20%), Positives = 289/737 (39%), Gaps = 149/737 (20%)
Query: 14 SQQEELADLPKDYLLSESEDEGDND---GERKH-----QKLLEAISSLDGKNRRKLAERS 65
++++EL ++ D E+E N E+K Q L E + +G ++ E+
Sbjct: 915 AKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKV 974
Query: 66 EASLKVSEF--------NVSSEGSGEKLVLADLLEPVKTSSSLATVK---KQLSRVKSKK 114
A K+ + + +S+ EK ++ D + + SS LA + K L+++++K+
Sbjct: 975 TAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRI--AECSSQLAEEEEKAKNLAKIRNKQ 1032
Query: 115 TV-----ELPLNKEEIERIHREVAFNKT-AQVLSKWDPVVLKNRQAEQLVFPLEKEEPAI 168
V E L KEE R E A K + D + Q ++L L K+E
Sbjct: 1033 EVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEE- 1091
Query: 169 APIEHVLSGWKARTPLEQEIFNLLHKNKQ-PVTDPLLTPVEKASLRAMSLEEAKMRRAEL 227
L G AR E LHKN V L + + E+A +AE
Sbjct: 1092 ------LQGALARGDDET-----LHKNNALKVVRELQAQIAELQ-EDFESEKASRNKAEK 1139
Query: 228 QRARALQSYYEAKARRE---------KKIKSKKYHKVVKKGKA-----KKALKEFEQLRK 273
Q+ + K E +++++K+ +V + KA K + + +R+
Sbjct: 1140 QKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQ 1199
Query: 274 VNPAAALEEL-EKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKE 332
+ A ALEEL E++E+A+ + +L+ G +K + + + +Q E K K+
Sbjct: 1200 RH-ATALEELSEQLEQAKRF-KANLEKNKQGLETDNKELACEVKV-LQQVKAESEHKRKK 1256
Query: 333 LTQKLQ---------------VASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWML 377
L ++Q +A ++ + + ++V LL ++ D + L
Sbjct: 1257 LDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAAS---L 1313
Query: 378 RSCTSDTKEAATQEDPEQLP-ELEAHGVSESEGEERPVAEEEILLREFEERRSLRKRSEL 436
S DT+E +E ++L + E + + EEE R+ E++ L +S+L
Sbjct: 1314 ESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQL 1373
Query: 437 SQDAEPA----GSQETKDSGSQEVLSELRVLSQKLKE----------------------- 469
+ + G+ E+ + +++L + LSQ+L+E
Sbjct: 1374 ADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLT 1433
Query: 470 ---NHQSR-----------------KQKASSEGTIPQVQREEPAPEEEEPLLLQRPERVQ 509
+HQ + ++K+ S + R E E+E L +
Sbjct: 1434 VDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSL---AR 1490
Query: 510 TLEELEELGKEECFQNKELPRPVLEGQQSERTP--NNRPDAPKEKKKKEQMID-----LQ 562
LEE E +E QNK+L R +E S + N + K K+ EQ ++ L+
Sbjct: 1491 ALEEALEAKEEFERQNKQL-RADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLE 1549
Query: 563 NL-------------LTTQSPSVKSLAVPTIEELEDEEERNHRQMIKEAFAGDDVIRDFL 609
L L ++K+ ++ +++ E R +IK+ + + D
Sbjct: 1550 ELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDER 1609
Query: 610 KEKREAVEASKPKDVDL 626
K++ AV + K ++DL
Sbjct: 1610 KQRALAVASKKKMEIDL 1626
Score = 53.9 bits (128), Expect = 5e-07
Identities = 122/551 (22%), Positives = 222/551 (40%), Gaps = 75/551 (13%)
Query: 5 RLAESLLALSQQEELADLPKDYLLSESED-EGDNDGERKHQKLLEAISSLDGKNRRKL-A 62
R A +L LS+Q E A K L + E DN K+L+ + + R+KL A
Sbjct: 1200 RHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDA 1259
Query: 63 ERSEASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSSLATVKKQLSRVKSKKTVELPLNK 122
+ E KVSE G++L + + K + L V L + KK ++ +
Sbjct: 1260 QVQELHAKVSE--------GDRLRVELAEKASKLQNELDNVSTLLEEAE-KKGIKFAKDA 1310
Query: 123 EEIE---RIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVLSGWK 179
+E + +E+ +T Q L+ + + L E+EE +
Sbjct: 1311 ASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEE-------------E 1357
Query: 180 ARTPLEQEIFNL---LHKNKQPVTDPLLT--PVEKASLRAMSLEEAKMRRAELQRARALQ 234
AR LE+++ L L K+ V D L T +E+A + + EA +R E ++A A
Sbjct: 1358 ARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLE-EKALAYD 1416
Query: 235 SYYEAKARREKKIKSKKY---HKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARM 291
+ K R ++++ H+ +K K+F+QL + + E+ ++A
Sbjct: 1417 KLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEA 1476
Query: 292 MERMSLKHQNSGKWAKSKAIMAKY-----------DLEARQAMQEQLSKNKELTQKLQVA 340
R S A +A+ AK D+E + ++ + KN +K + A
Sbjct: 1477 EAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRA 1536
Query: 341 SESEEEEGGT--EDVEELL--VPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQEDP--- 393
E + EE T E++E+ L D +++N R T++ +E
Sbjct: 1537 LEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDL--QTRDEQNEEKKRLL 1594
Query: 394 -EQLPELEAHGVSESEGEERPVAEEEILLREFEERRSLRKRSELSQDAEPAGSQ-ETKDS 451
+Q+ ELEA E E ++R +A + + ++ D + +Q E +
Sbjct: 1595 IKQVRELEAE--LEDERKQRALA--------------VASKKKMEIDLKDLEAQIEAANK 1638
Query: 452 GSQEVLSELRVLSQKLKE-NHQSRKQKASSEGTIPQVQREEPAPEEEEPLLLQRPERVQT 510
EV+ +LR L ++K+ + + +AS + Q + E + E +LQ E + +
Sbjct: 1639 ARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELAS 1698
Query: 511 LEELEELGKEE 521
E ++E
Sbjct: 1699 SERARRHAEQE 1709
Score = 52.4 bits (124), Expect = 2e-06
Identities = 137/643 (21%), Positives = 263/643 (40%), Gaps = 135/643 (20%)
Query: 10 LLALSQQEELADLPKDYLLSESEDEGDNDGE-----RKHQKLLEAISSLDGKNRRKLAER 64
LL +++QEE + LL E + +GE RKHQ+LLE
Sbjct: 844 LLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLE---------------- 887
Query: 65 SEASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSSLATVKKQLSRVKSKKTVELPLNKEE 124
EK +LA+ L+ + A ++ +R+ +KK + +
Sbjct: 888 ------------------EKNILAEQLQ--AETELFAEAEEMRARLAAKKQELEEILHDL 927
Query: 125 IERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPA--IAPIEHVLSGWKART 182
R+ E N+ Q K + L L++EE A +E V + K +
Sbjct: 928 ESRVEEEEERNQILQNEKK-----KMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIK- 981
Query: 183 PLEQEIFNLLHKNKQPVTDPLLTP---VEKASLRAMSLEEAKMRRAELQRARALQSYYEA 239
+E+EI L +N + + + L E +S A E+AK + + S E
Sbjct: 982 KMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEE 1041
Query: 240 KARREKKIKSKKYHKVVKK--GKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERM-- 295
+ ++E+K + ++ K +K G+ + +L+ A ++EL K++ A+ E +
Sbjct: 1042 RLKKEEKTR-QELEKAKRKLDGETTDLQDQIAELQ-----AQIDEL-KLQLAKKEEELQG 1094
Query: 296 SLKHQNSGKWAKSKAIMAKYDLEARQA------MQEQLSKNKELTQKLQVASESEEEEGG 349
+L + K+ A+ +L+A+ A E+ S+NK QK + SEE E
Sbjct: 1095 ALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDL---SEELEAL 1151
Query: 350 TEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGVSESEG 409
++E+ L T+ +E T+ + +++ EL+ E++
Sbjct: 1152 KTELEDTL---------------------DTTAAQQELRTKRE-QEVAELKKALEEETKN 1189
Query: 410 EERPVAE----EEILLREFEERRSLRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQ 465
E + + L E E+ KR + + + G ++ ++E+ E++VL Q
Sbjct: 1190 HEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQG----LETDNKELACEVKVLQQ 1245
Query: 466 -KLKENHQSRKQKAS--------SEGTIPQVQREEPAPEEEEPL-----LLQRPER---- 507
K + H+ +K A SEG +V+ E A + + L LL+ E+
Sbjct: 1246 VKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIK 1305
Query: 508 --------VQTLEELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKK--KEQ 557
L++ +EL +EE Q L + + ++ + + + + +E +K ++Q
Sbjct: 1306 FAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQ 1365
Query: 558 MIDLQNLLTTQSPSVKSLAVPTIEELEDEEERNHRQMIKEAFA 600
++ LQ+ L V + TIE LE+ + ++++K+A A
Sbjct: 1366 VLALQSQLADTKKKVDD-DLGTIESLEEAK----KKLLKDAEA 1403
Score = 45.8 bits (107), Expect = 1e-04
Identities = 86/387 (22%), Positives = 161/387 (41%), Gaps = 64/387 (16%)
Query: 286 IEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKE-LTQKLQVASE-- 342
++ R E + K + K K K + +LE + +QL + K L ++LQ +E
Sbjct: 845 LQVTRQEEELQAKDEELLK-VKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELF 903
Query: 343 SEEEE------GGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQL 396
+E EE +++EE+L D+ + V+ + + +A Q+ EQL
Sbjct: 904 AEAEEMRARLAAKKQELEEIL-HDLESRVEEEEERNQ---ILQNEKKKMQAHIQDLEEQL 959
Query: 397 PELEAHGVSESEGEERPVAE-------EEILLREFEERRSLRKRSELSQDAEPAGSQETK 449
E E G + E+ AE EEILL E + + ++++ + SQ +
Sbjct: 960 DEEE--GARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAE 1017
Query: 450 DSGSQEVLSELR--------VLSQKLKENHQSR------KQKASSEGTIPQVQREEPAPE 495
+ + L+++R L ++LK+ ++R K+K E T Q Q E +
Sbjct: 1018 EEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQ 1077
Query: 496 EEEPLLLQRPERVQTLEELEELGKEECFQN-------KELPRPVLEGQ---QSERTPNNR 545
+E L LQ ++ + L+ G +E +EL + E Q +SE+ N+
Sbjct: 1078 IDE-LKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNK 1136
Query: 546 PDAPKEKKKKEQMIDLQNLLTTQSPSVKSLA------------VPTIEELEDEEERNHRQ 593
EK+K++ +L+ L T ++ + A V +++ +EE +NH
Sbjct: 1137 ----AEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEA 1192
Query: 594 MIKEAFAGDDVIRDFLKEKREAVEASK 620
I++ + L E+ E + K
Sbjct: 1193 QIQDMRQRHATALEELSEQLEQAKRFK 1219
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 57.4 bits (137), Expect = 5e-08
Identities = 139/673 (20%), Positives = 265/673 (39%), Gaps = 89/673 (13%)
Query: 13 LSQQEELADLPKDYLLSESEDEGDNDGERKHQKLLEAISSLDGKNRRKLAERSEASLKVS 72
L Q +E + +D L S+ D + + + + Q L A+ SL +S+ S +VS
Sbjct: 934 LKQLQESLQIERDQLKSDIHDTVNMNIDTQEQ-LRNALESLKQHQETINTLKSKISEEVS 992
Query: 73 EFNVSSEGSGE-------KLVLADL---LEPVKTSSSLATVKKQLSRVKSKKTVELPLNK 122
E +GE K+V D LE T + A VK + +K L K
Sbjct: 993 RNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEK 1052
Query: 123 EEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVF---PLEKEEPAIAPIE-HVLS-- 176
E++++ V K + + + E+L L+K++ +A + H +
Sbjct: 1053 NELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKE 1112
Query: 177 GWKART---------PLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAEL 227
G +RT L+++ L K +Q LL E+ S + E + + EL
Sbjct: 1113 GELSRTCDRLAEVEEKLKEKSQQLQEKQQQ-----LLNVQEEMSEMQKKINEIENLKNEL 1167
Query: 228 QRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIE 287
+ + E + + ++ Y +V K +K LKE ++ + + +IE
Sbjct: 1168 KNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIE 1227
Query: 288 KARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESEEEE 347
+ + LK + + I E R+++ E+ ++ TQ L+ + +EE
Sbjct: 1228 ATGLQTKEELKIAHIHLKEHQETID-----ELRRSVSEKTAQIIN-TQDLEKSHTKLQEE 1281
Query: 348 GGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGVSES 407
E+ L+P+V EV + N L + S TK++ T E ES
Sbjct: 1282 IPVLHEEQELLPNV-KEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQES 1340
Query: 408 EGEERPVAEEEILLREFEE-------------RRSLRKRSELSQDAEPAGSQETKDSGSQ 454
+ E + + +E L+ +E R +L K E E + + + KD+ +
Sbjct: 1341 QEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETT 1400
Query: 455 EVLSE-----------LRV------LSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEE 497
+++SE LR+ LS++L+E+H K A + + ++Q
Sbjct: 1401 KIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQE-------- 1452
Query: 498 EPLLLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQ 557
+ + E Q E ++E+ + +EL ++ E T N EK+ +
Sbjct: 1453 ----VLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEIS 1508
Query: 558 MIDLQNLLTTQSPSVKSLAVPTIEELEDEEERNHRQMIKEAFAGDDVIRDF---LKEKRE 614
I Q ++ I+E+ ++EE+ + + I E + ++ F K K
Sbjct: 1509 TIQ------KQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDS 1562
Query: 615 AVEASKPKDVDLT 627
A+++ + K ++LT
Sbjct: 1563 ALQSIESKMLELT 1575
Score = 54.7 bits (130), Expect = 3e-07
Identities = 120/628 (19%), Positives = 257/628 (40%), Gaps = 69/628 (10%)
Query: 40 ERKHQKLLEAISSLDGKNRRKLAERSEASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSS 99
E KH +L E I R LA+ E+ K + E E + +E K S
Sbjct: 1362 EVKHDQLKEHI-------RETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDS 1414
Query: 100 LATVKKQLSRVKSKKTVE--------LPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKN 151
A ++ ++ + K ++ + K++++R+ +EV +++ Q+ +V K+
Sbjct: 1415 -ALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRL-QEVLQSESDQLKENIKEIVAKH 1472
Query: 152 RQAEQLVFPLEKEEPAIAPIEHVLSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPVEKAS 211
+ E+ L+ + E ++ + ++ + + K + + D L +++
Sbjct: 1473 LETEE---ELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIY 1529
Query: 212 LRAMSLEEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQL 271
+ ++ + ++ L+ + E + ++ ++S + + + +++ +E + +
Sbjct: 1530 EKEEQFNIKQISEVQ-EKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIM 1588
Query: 272 RKVNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAK-YDLEARQAMQEQLSKN 330
K EE++++++A +ER LK AK K K Y A+ E K
Sbjct: 1589 IKEK-----EEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKM 1643
Query: 331 KEL--------TQKLQVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTS 382
E+ TQKL + + E T+ + E L + + V D LRS
Sbjct: 1644 CEIEHLKEQFETQKLNLENIETENIRLTQILHENL--EEMRSVTKERDD-----LRSVEE 1696
Query: 383 DTKEAATQ----------EDPEQLPELEAHGVSESEGEERPVAEEEILLREFEERRSLRK 432
K Q D E+ EL+ + E +E I+ + E +++K
Sbjct: 1697 TLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQK 1756
Query: 433 RSELSQDAEPAGSQETKD---------SGSQEVLSELR-VLSQKLKENHQSRKQKASSEG 482
E S DA A + ++ QE + +LR ++S+K + +K +S
Sbjct: 1757 DLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNA 1816
Query: 483 TIPQVQREEPAPEEEEPLLLQRP--ERVQTLEELEELGKEECFQNKELPRPVLEG-QQSE 539
+ Q + +E E + + L++ E + + E+E+L K+ Q+ L + +E ++
Sbjct: 1817 KL-QEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQ 1875
Query: 540 RTPNNRPDAPKEKKKKEQMIDLQNLLTTQSPSVK-SLAVPTIEELEDEEE-RNHRQMIKE 597
+ N + K+++ + ++ L + +K SL +LE ++E + R + KE
Sbjct: 1876 KLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKE 1935
Query: 598 AFAGDDVIRDFLKEKREAVEASKPKDVD 625
D +R+ + EK + + KD+D
Sbjct: 1936 HKETVDKLREKISEKTIQI-SDIQKDLD 1962
Score = 32.0 bits (71), Expect = 2.2
Identities = 68/325 (20%), Positives = 145/325 (44%), Gaps = 44/325 (13%)
Query: 208 EKASLRAMSLEEAKMRRAEL-----QRARALQSYYEAKARREKKIKSKKYHKVVKKGKAK 262
E A LR+ +LE K + EL Q +Q Y + ++++KK +V + + +
Sbjct: 640 ESAFLRSENLE-LKEKMKELATTYKQMENDIQLY-------QSQLEAKKKMQVDLEKELQ 691
Query: 263 KALKEFEQLRKVN----PAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLE 318
A E +L + P L LE K +++ K + + + I+ +L+
Sbjct: 692 SAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLS-ELK 750
Query: 319 ARQAMQEQLSKN-KELTQKLQVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWML 377
+ + E+L K ++ +++L + + +++ +E V ++ E+ D
Sbjct: 751 SLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDD------ 804
Query: 378 RSCTSDTKEAATQEDPEQLPELEAHGVSESEGEERPVAEEEILLREFEERRSLRKRSELS 437
T+ + +T ++ + L + E + + V EE + + E +L K ++
Sbjct: 805 -LATTQSNYKSTDQEFQNFKTLHM----DFEQKYKMVLEENERMNQ--EIVNLSKEAQKF 857
Query: 438 QDAEPAGSQETKDS-GSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEE 496
+ G+ +T+ S +QE+ + R + ++L E Q ++Q + + T+ V+RE+ E
Sbjct: 858 DSS--LGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITE 915
Query: 497 EEPLLLQRPERVQTLEELEELGKEE 521
+ LQ QTLEE++ L +E+
Sbjct: 916 K----LQ-----QTLEEVKTLTQEK 931
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 57.0 bits (136), Expect = 6e-08
Identities = 125/623 (20%), Positives = 268/623 (43%), Gaps = 62/623 (9%)
Query: 4 NRLAESLLALSQQEEL--ADLPKDYLLSESEDEGDNDGERKHQKLLEAISSLDGKNRRKL 61
N+L E L++ ++ +L ++L + L +E + + K K + G+ +
Sbjct: 569 NQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLE 628
Query: 62 AERSEASLKVSEFNVSSEGSGEKLVLA-DLLEPVKTSSSLATVKKQLSRVKSKKTVELPL 120
+E LK+ E E + + A +LL+ ++ + A +++L ++++++ +
Sbjct: 629 KINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERA--ERELEKLQNREDSSEGI 686
Query: 121 NK-----EEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVL 175
K EE+E HRE AQV ++ V LK ++ + E I +++ +
Sbjct: 687 RKKLVEAEELEEKHRE------AQVSAQHLEVHLKQKE--------QHYEEKIKVLDNQI 732
Query: 176 SGWKARTPLEQEIFNLLHKNKQPVTDP-LLTPVEKASLRAM-----SLEEAKMRRAELQR 229
K ++ + N++ ++++ + + +KA + AM SLE+ + +E +
Sbjct: 733 ---KKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANK 789
Query: 230 ARALQSYY---EAKARRE--KKIKSKKYHKVVKKGKAKKALKEFE-QLRKVNPAAALEEL 283
A S + KA+ E +++ +K++ + GK + ++ E QL K++ ++
Sbjct: 790 LAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKN 849
Query: 284 EKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASES 343
+E + +SL+H+ K + + L+ R++ L + + +++
Sbjct: 850 RLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKT 909
Query: 344 EEEEGGTEDVEEL-LVPDVVNEVQMNADGPNPWMLRSCT--SDTKEAATQ--EDPEQLPE 398
E EE E EE+ + +E+Q D + SCT +D +E Q ED +L
Sbjct: 910 ELEETTAEAEEEIQALTAHRDEIQRKFDA----LRNSCTVITDLEEQLNQLTEDNAELNN 965
Query: 399 LEAHGVSESEGEERPVAEEEILLREFEE--RRSLRKRS-ELSQDAEPAGSQETKDSGSQE 455
+ +S+ E +E + LR + RR + +R +L+ + + +T + +E
Sbjct: 966 QNFY-LSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEE 1024
Query: 456 VLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLLQRPERVQTLEELE 515
+ +L L+ +L E + + S G + Q E E + L ++ R + + +
Sbjct: 1025 QVMDLEALNDELLEKERQWEAWRSVLGD-EKSQFECRVRELQRMLDTEKQSRARADQRIT 1083
Query: 516 ELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMIDLQNLLTTQSPSVKSL 575
E + KE +L QQ+ + ++K K E + D N L + ++
Sbjct: 1084 ESRQVVELAVKEHKAEILALQQALK---------EQKLKAESLSDKLNDLEKKHAMLEMN 1134
Query: 576 AVPTIEELEDEEERNHRQMIKEA 598
A ++LE E E R + ++A
Sbjct: 1135 ARSLQQKLETERELKQRLLEEQA 1157
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.126 0.341
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,876,236
Number of Sequences: 37866
Number of extensions: 1504424
Number of successful extensions: 10591
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 90
Number of HSP's successfully gapped in prelim test: 975
Number of HSP's that attempted gapping in prelim test: 7354
Number of HSP's gapped (non-prelim): 2732
length of query: 771
length of database: 18,247,518
effective HSP length: 110
effective length of query: 661
effective length of database: 14,082,258
effective search space: 9308372538
effective search space used: 9308372538
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.