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Search of human proteins with 208022641
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|208022641 elongin A [Homo sapiens]
(798 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|208022641 elongin A [Homo sapiens] 1612 0.0
gi|45439357 elongin A2 [Homo sapiens] 609 e-174
gi|156938279 transcription elongation factor B polypeptide 3C [H... 283 6e-76
gi|154816198 transcription elongation factor B polypeptide 3C-li... 280 4e-75
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 71 3e-12
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 60 8e-09
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 57 9e-08
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 57 9e-08
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap... 54 4e-07
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 54 7e-07
gi|125656165 THO complex 2 [Homo sapiens] 53 1e-06
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap... 53 1e-06
gi|239757016 PREDICTED: similar to RNA polymerase II transcripti... 53 1e-06
gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [... 52 2e-06
gi|154146223 splicing factor, arginine/serine-rich 130 [Homo sap... 52 2e-06
gi|154146193 splicing factor, arginine/serine-rich 130 [Homo sap... 52 2e-06
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ... 52 3e-06
gi|239749424 PREDICTED: hypothetical protein XP_002347041 [Homo ... 51 4e-06
gi|5803191 transcription elongation factor A 1 isoform 1 [Homo s... 51 4e-06
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens] 50 8e-06
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 50 8e-06
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 50 8e-06
gi|213385278 TNF receptor-associated factor 3 interacting protei... 50 8e-06
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 50 8e-06
gi|41350335 transcription elongation factor A (SII), 3 [Homo sap... 50 1e-05
gi|27477095 nuclear receptor binding SET domain protein 1 isofor... 49 1e-05
gi|19923586 nuclear receptor binding SET domain protein 1 isofor... 49 1e-05
gi|104526627 triadin [Homo sapiens] 49 1e-05
gi|52426743 cisplatin resistance-associated overexpressed protei... 49 1e-05
gi|19923485 cisplatin resistance-associated overexpressed protei... 49 1e-05
>gi|208022641 elongin A [Homo sapiens]
Length = 798
Score = 1612 bits (4173), Expect = 0.0
Identities = 798/798 (100%), Positives = 798/798 (100%)
Query: 1 MHGGRSCGPRTRREPSSGEEAAPVTAMAAESALQVVEKLQARLAANPDPKKLLKYLKKLS 60
MHGGRSCGPRTRREPSSGEEAAPVTAMAAESALQVVEKLQARLAANPDPKKLLKYLKKLS
Sbjct: 1 MHGGRSCGPRTRREPSSGEEAAPVTAMAAESALQVVEKLQARLAANPDPKKLLKYLKKLS 60
Query: 61 TLPITVDILAETGVGKTVNSLRKHEHVGSFARDLVAQWKKLVPVERNAEPDEQDFEKSNS 120
TLPITVDILAETGVGKTVNSLRKHEHVGSFARDLVAQWKKLVPVERNAEPDEQDFEKSNS
Sbjct: 61 TLPITVDILAETGVGKTVNSLRKHEHVGSFARDLVAQWKKLVPVERNAEPDEQDFEKSNS 120
Query: 121 RKRPRDALQKEEEMEGDYQETWKATGSRSYSPDHRQKKHRKLSELERPHKVSHGHERRDE 180
RKRPRDALQKEEEMEGDYQETWKATGSRSYSPDHRQKKHRKLSELERPHKVSHGHERRDE
Sbjct: 121 RKRPRDALQKEEEMEGDYQETWKATGSRSYSPDHRQKKHRKLSELERPHKVSHGHERRDE 180
Query: 181 RKRCHRMSPTYSSDPESSDYGHVQSPPSCTSPHQMYVDHYRSLEEDQEPIVSHQKPGKGH 240
RKRCHRMSPTYSSDPESSDYGHVQSPPSCTSPHQMYVDHYRSLEEDQEPIVSHQKPGKGH
Sbjct: 181 RKRCHRMSPTYSSDPESSDYGHVQSPPSCTSPHQMYVDHYRSLEEDQEPIVSHQKPGKGH 240
Query: 241 SNAFQDRLGASQERHLGEPHGKGVVSQNKEHKSSHKDKRPVDAKSDEKASVVSREKSHKA 300
SNAFQDRLGASQERHLGEPHGKGVVSQNKEHKSSHKDKRPVDAKSDEKASVVSREKSHKA
Sbjct: 241 SNAFQDRLGASQERHLGEPHGKGVVSQNKEHKSSHKDKRPVDAKSDEKASVVSREKSHKA 300
Query: 301 LSKEENRRPPSGDNAREKPPSSGVKKEKDREGSSLKKKCLPPSEAASDNHLKKPKHRDPE 360
LSKEENRRPPSGDNAREKPPSSGVKKEKDREGSSLKKKCLPPSEAASDNHLKKPKHRDPE
Sbjct: 301 LSKEENRRPPSGDNAREKPPSSGVKKEKDREGSSLKKKCLPPSEAASDNHLKKPKHRDPE 360
Query: 361 KAKLDKSKQGLDSFDTGKGAGDLLPKVKEKGSNNLKTPEGKVKTNLDRKSLGSLPKVEET 420
KAKLDKSKQGLDSFDTGKGAGDLLPKVKEKGSNNLKTPEGKVKTNLDRKSLGSLPKVEET
Sbjct: 361 KAKLDKSKQGLDSFDTGKGAGDLLPKVKEKGSNNLKTPEGKVKTNLDRKSLGSLPKVEET 420
Query: 421 DMEDEFEQPTMSFESYLSYDQPRKKKKKIVKTSATALGDKGLKKNDSKSTGKNLDSVQKL 480
DMEDEFEQPTMSFESYLSYDQPRKKKKKIVKTSATALGDKGLKKNDSKSTGKNLDSVQKL
Sbjct: 421 DMEDEFEQPTMSFESYLSYDQPRKKKKKIVKTSATALGDKGLKKNDSKSTGKNLDSVQKL 480
Query: 481 PKVNKTKSEKPAGADLAKLRKVPDVLPVLPDLPLPAIQANYRPLPSLELISSFQPKRKAF 540
PKVNKTKSEKPAGADLAKLRKVPDVLPVLPDLPLPAIQANYRPLPSLELISSFQPKRKAF
Sbjct: 481 PKVNKTKSEKPAGADLAKLRKVPDVLPVLPDLPLPAIQANYRPLPSLELISSFQPKRKAF 540
Query: 541 SSPQEEEEAGFTGRRMNSKMQVYSGSKCAYLPKMMTLHQQCIRVLKNNIDSIFEVGGVPY 600
SSPQEEEEAGFTGRRMNSKMQVYSGSKCAYLPKMMTLHQQCIRVLKNNIDSIFEVGGVPY
Sbjct: 541 SSPQEEEEAGFTGRRMNSKMQVYSGSKCAYLPKMMTLHQQCIRVLKNNIDSIFEVGGVPY 600
Query: 601 SVLEPVLERCTPDQLYRIEEYNHVLIEETDQLWKVHCHRDFKEERPEEYESWREMYLRLQ 660
SVLEPVLERCTPDQLYRIEEYNHVLIEETDQLWKVHCHRDFKEERPEEYESWREMYLRLQ
Sbjct: 601 SVLEPVLERCTPDQLYRIEEYNHVLIEETDQLWKVHCHRDFKEERPEEYESWREMYLRLQ 660
Query: 661 DAREQRLRVLTKNIQFAHANKPKGRQAKMAFVNSVAKPPRDVRRRQEKFGTGGAAVPEKI 720
DAREQRLRVLTKNIQFAHANKPKGRQAKMAFVNSVAKPPRDVRRRQEKFGTGGAAVPEKI
Sbjct: 661 DAREQRLRVLTKNIQFAHANKPKGRQAKMAFVNSVAKPPRDVRRRQEKFGTGGAAVPEKI 720
Query: 721 KIKPAPYPMGSSHASASSISFNPSPEEPAYDGPSTSSAHLAPVVSSTVSYDPRKPTVKKI 780
KIKPAPYPMGSSHASASSISFNPSPEEPAYDGPSTSSAHLAPVVSSTVSYDPRKPTVKKI
Sbjct: 721 KIKPAPYPMGSSHASASSISFNPSPEEPAYDGPSTSSAHLAPVVSSTVSYDPRKPTVKKI 780
Query: 781 APMMAKTIKAFKNRFSRR 798
APMMAKTIKAFKNRFSRR
Sbjct: 781 APMMAKTIKAFKNRFSRR 798
>gi|45439357 elongin A2 [Homo sapiens]
Length = 753
Score = 609 bits (1570), Expect = e-174
Identities = 373/787 (47%), Positives = 487/787 (61%), Gaps = 52/787 (6%)
Query: 28 AAESALQVVEKLQARLAANPDPKKLLKYLKKLSTLPITVDILAETGVGKTVNSLRKHEHV 87
A + L VEKLQ RLA +PKKL KYL+KLS LP+T DILAETG+ KTV LRKH+HV
Sbjct: 3 AGSTTLHAVEKLQVRLATKTEPKKLEKYLQKLSALPMTADILAETGIRKTVKRLRKHQHV 62
Query: 88 GSFARDLVAQWKKLVPVERNAEPDEQDFEKSNSRKRPRDALQKEEEMEGDYQETWKATGS 147
G FARDL A+WKKLV V+RN P QD E+S SR+R +ALQ +E+ G + E A S
Sbjct: 63 GDFARDLAARWKKLVLVDRNTRPGPQDPEESASRQRFGEALQDQEKAWG-FPENATAPRS 121
Query: 148 RSYSPDHRQKKHRKLSELERPHKVSHGHERRDERKRCHRMSPTYSSDPESSDYGHVQSPP 207
S+SP+HR+ R +RPH SH E R ERK C R++P +D G ++ P
Sbjct: 122 PSHSPEHRRTARRTPPGQQRPHPRSHSREPRAERK-CPRIAP--------ADSGRYRASP 172
Query: 208 SCTSPHQMYVDHYRSLEEDQEPIVSHQKPGKGHSNAFQDRLGASQERHLGEPHGKGVVSQ 267
+ T+P +M E EP ++PG+GH++A Q G+P GK VVS
Sbjct: 173 TRTAPLRM--------PEGPEPAAPGKQPGRGHTHAAQGGPLLCPGCQ-GQPQGKAVVSH 223
Query: 268 NKEHKSSHKDKRPVDAKSDEKASVVSREKSHKALSKEENRRPPSGDNAREKPPSS-GVKK 326
+K HKSS ++KRP+ A+ D + + REKS A +EE R PS +AR++ PS K
Sbjct: 224 SKGHKSSRQEKRPLCAQGDWHSPTLIREKSCGACLREETPRMPSWASARDRQPSDFKTDK 283
Query: 327 EKDREGSSLKKKCLPPSEAASDNHLKKPKHRDPEKAKLDKSKQGLDSFDTGKGAGDLLPK 386
E + GS + +P E A D+H K+P+H + +K + LD D G G L P+
Sbjct: 284 EGGQAGSGQR---VPALEEAPDSHQKRPQH-----SHSNKKRPSLDGRDPGNGTHGLSPE 335
Query: 387 VKEKGSNNLKTPEGKVKT-NLDRKSLGSLPKVEETDMEDEFEQPTMSFESYLSYDQPRKK 445
KE+ SN+ +T EGK T +LDR S+ SL +VEE DM +EFEQPT+S E YL+YDQ RK+
Sbjct: 336 EKEQLSNDRETQEGKPPTAHLDRTSVSSLSEVEEVDMAEEFEQPTLSCEKYLTYDQLRKQ 395
Query: 446 KKKIVKTSATALGDKGLKKNDSKSTGKNLDSVQKLPKVNKTKSEK--PAGADLAKLRKVP 503
KKK K++ TALGDK K N+SK T ++ DS +KLP V +++SE+ AGAD A + VP
Sbjct: 396 KKKTGKSATTALGDKQRKANESKGTRESWDSAKKLPPVQESQSERLQAAGADSAGPKTVP 455
Query: 504 D-VLPVLPDLPLPAIQANYRPLPSLELISSFQPKRKAFSSPQEEEEAGFTGRRMNSKMQV 562
V L DL +QANY PL + ++S Q K +A SSP+ EEA F GRR+N+KM V
Sbjct: 456 SHVFSELWDLSEAWMQANYDPLSDSDSMTS-QAKPEALSSPKFREEAAFPGRRVNAKMPV 514
Query: 563 YSGSKCAYLPKMMTLHQQCIRVLKNNIDSIFEVGGVPYSVLEPVLERCTPDQLYRIEEYN 622
YSGS+ A ++ TL QQC +VL+NN D++ +VG VPY VLEPVLE PDQLYR ++ N
Sbjct: 515 YSGSRPACQLQVPTLRQQCAQVLRNNPDALSDVGEVPYWVLEPVLEGWRPDQLYRRKKDN 574
Query: 623 HVLIEETDQLWKVHCHRDFKEERPEEYESWREMYLRLQDAREQRLRVLTKNIQFAHANKP 682
H L+ ETD+L + HC +DFKEE+P+E ++WRE YLRL DA EQRLRV+T NI+ A N P
Sbjct: 575 HALVRETDELRRNHCFQDFKEEKPQENKTWREQYLRLPDAPEQRLRVMTTNIRSARGNNP 634
Query: 683 KGRQAKMAFVNSVAKPPRDVRRRQEKFGTGGAAVPEKIKIKPAPYPMGSSHASASSISFN 742
GR+AKM SVAK P D RRQEK + G A PE +IKPA P GSSH +S S
Sbjct: 635 NGREAKMICFKSVAKTPYDTSRRQEK--SAGDADPENGEIKPASKPAGSSHTPSSQSSSG 692
Query: 743 PS-----------PEEPAYDGPSTSSAHLAPVVSSTVSYDPRKPTVKKIAPMMAKTIKAF 791
PE+ A S+S+ H AP + RK KK+AP+MAK I+ +
Sbjct: 693 GGRDSSSSILRWLPEKRANPCLSSSNEHAAPAAKT------RKQAAKKVAPLMAKAIRDY 746
Query: 792 KNRFSRR 798
K RFSRR
Sbjct: 747 KRRFSRR 753
>gi|156938279 transcription elongation factor B polypeptide 3C [Homo
sapiens]
Length = 546
Score = 283 bits (723), Expect = 6e-76
Identities = 165/326 (50%), Positives = 213/326 (65%), Gaps = 16/326 (4%)
Query: 476 SVQKLPKVNKTKSEK--PAGADLAKLRKVPD-VLPVLPDLPLPAIQANYRPLPSLELISS 532
S QK P V +++SE+ AGAD A + VP V L D +QANY L + E ++S
Sbjct: 234 SAQKSPPVQESQSERLQAAGADSAGPKTVPSHVFSELWDPSEAWMQANYDLLSAFEAMTS 293
Query: 533 FQPKRKAFSSPQEEEEAGFTGRRMNSKMQVYSGSKCAYLPKMMTLHQQCIRVLKNNIDSI 592
Q +A S+P +EEA F GRR+N+KM VYSGS+ A ++ TL QQC+RV +NN D++
Sbjct: 294 -QANPEALSAPALQEEAAFPGRRVNAKMPVYSGSRPACQLQVPTLRQQCLRVPRNNPDAL 352
Query: 593 FEVGGVPYSVLEPVLERCTPDQLYRIEEYNHVLIEETDQLWKVHCHRDFKEERPEEYESW 652
+V GVPYSVLEPVLE TPDQLYR E+ N L ETD+LW++HC +DFKEE+P+E+ESW
Sbjct: 353 GDVEGVPYSVLEPVLEGWTPDQLYRTEKDNAALARETDELWRIHCLQDFKEEKPQEHESW 412
Query: 653 REMYLRLQDAREQRLRVLTKNIQFAHANKPKGRQAKMAFVNSVAKPPRDVRRRQEKFGTG 712
RE+YLRL+DAREQRLRV+T I+ A NKP GRQ KM NSVAK P D RRQEK +
Sbjct: 413 RELYLRLRDAREQRLRVVTTKIRSARENKPSGRQTKMICFNSVAKTPYDASRRQEK--SA 470
Query: 713 GAAVPEKIKIKPAPYPMGSSHASASSISFNPSPEEPAYDGPSTSSAHLAPVVSSTVSYDP 772
GAA P +++PAP P GSS A + + + G +S+ H AP +
Sbjct: 471 GAADPGNGEMEPAPKPAGSSQAPSGL----GDGDGGSVSGGGSSNRHAAPADKT------ 520
Query: 773 RKPTVKKIAPMMAKTIKAFKNRFSRR 798
RK KK+AP+MAK I+ +K RFSRR
Sbjct: 521 RKQAAKKVAPLMAKAIRDYKGRFSRR 546
Score = 188 bits (478), Expect = 1e-47
Identities = 121/276 (43%), Positives = 158/276 (57%), Gaps = 27/276 (9%)
Query: 28 AAESALQVVEKLQARLAANPDPKKLLKYLKKLSTLPITVDILAETGVGKTVNSLRKHEHV 87
A + L+ V KLQ RLA +PKKL KYL+KLS LP+T DILAETG+ KTV LRKH+HV
Sbjct: 3 AGSTTLRAVGKLQVRLATKTEPKKLEKYLQKLSALPMTADILAETGIRKTVKRLRKHQHV 62
Query: 88 GSFARDLVAQWKKLVPVERNAEPDEQDFEKSNSRKRPRDALQKEEEMEGDYQETWKATGS 147
G FARDL A+WKKLV V+RN PD QD E+S SR+R +ALQ+ E+ G + E A S
Sbjct: 63 GDFARDLAARWKKLVLVDRNTGPDPQDPEESASRQRFGEALQEREKAWG-FPENATAPRS 121
Query: 148 RSYSPDHRQKKHRKLSELERPHKVSHGHERRDERKRCHRMSPTYSSDPESSDYGHVQSPP 207
S+SP+HR+ R +RPH S E R ERKR RM+P +D G + PP
Sbjct: 122 PSHSPEHRRTARRTPPGQQRPHPRSPSREPRAERKR-PRMAP--------ADSGPHRDPP 172
Query: 208 SCTSPHQMYVDHYRSLEEDQEPIVSHQKPGKGHSNAFQ--DRLGASQERHLGEPHGKGVV 265
+ T+P M E EP V ++PG+GH++A Q LG + G+P G+ V
Sbjct: 173 TRTAPLPM--------PEGPEPAVPGEQPGRGHAHAAQGGPLLGQGCQ---GQPQGEAVG 221
Query: 266 SQNKEHKSSH----KDKRPVDAKSDEKASVVSREKS 297
S +K HKSS + PV E+ + +
Sbjct: 222 SHSKGHKSSRGASAQKSPPVQESQSERLQAAGADSA 257
>gi|154816198 transcription elongation factor B polypeptide 3C-like
[Homo sapiens]
Length = 546
Score = 280 bits (716), Expect = 4e-75
Identities = 164/326 (50%), Positives = 212/326 (65%), Gaps = 16/326 (4%)
Query: 476 SVQKLPKVNKTKSEK--PAGADLAKLRKVPD-VLPVLPDLPLPAIQANYRPLPSLELISS 532
S QK P V +++SE+ AGAD A + VP V L D +QANY L + E ++S
Sbjct: 234 SAQKSPPVQESQSERLQAAGADSAGPKTVPSHVFSELWDPSEAWMQANYDLLSAFEAMTS 293
Query: 533 FQPKRKAFSSPQEEEEAGFTGRRMNSKMQVYSGSKCAYLPKMMTLHQQCIRVLKNNIDSI 592
Q +A S+P +EEA F GRR+N+KM VYSGS+ A ++ TL QQC+RV +NN D++
Sbjct: 294 -QANPEALSAPTLQEEAAFPGRRVNAKMPVYSGSRPACQLQVPTLRQQCLRVPRNNPDAL 352
Query: 593 FEVGGVPYSVLEPVLERCTPDQLYRIEEYNHVLIEETDQLWKVHCHRDFKEERPEEYESW 652
+V GVPYSVLEPVLE TPDQ YR E+ N L ETD+LW++HC +DFKEE+P+E+ESW
Sbjct: 353 GDVEGVPYSVLEPVLEGWTPDQPYRTEKDNAALARETDELWRIHCLQDFKEEKPQEHESW 412
Query: 653 REMYLRLQDAREQRLRVLTKNIQFAHANKPKGRQAKMAFVNSVAKPPRDVRRRQEKFGTG 712
RE+YLRL+DAREQRLRV+T I+ A NKP GRQ KM NSVAK P D RRQEK +
Sbjct: 413 RELYLRLRDAREQRLRVVTTKIRSARENKPSGRQTKMICFNSVAKTPYDASRRQEK--SA 470
Query: 713 GAAVPEKIKIKPAPYPMGSSHASASSISFNPSPEEPAYDGPSTSSAHLAPVVSSTVSYDP 772
GAA P +++PAP P GSS A + + + G +S+ H AP +
Sbjct: 471 GAADPGNGEMEPAPKPAGSSQAPSGL----GDGDGGSVSGGGSSNRHAAPADKT------ 520
Query: 773 RKPTVKKIAPMMAKTIKAFKNRFSRR 798
RK KK+AP+MAK I+ +K RFSRR
Sbjct: 521 RKQAAKKVAPLMAKAIRDYKGRFSRR 546
Score = 188 bits (478), Expect = 1e-47
Identities = 121/276 (43%), Positives = 158/276 (57%), Gaps = 27/276 (9%)
Query: 28 AAESALQVVEKLQARLAANPDPKKLLKYLKKLSTLPITVDILAETGVGKTVNSLRKHEHV 87
A + L+ V KLQ RLA +PKKL KYL+KLS LP+T DILAETG+ KTV LRKH+HV
Sbjct: 3 AGSTTLRAVGKLQVRLATKTEPKKLEKYLQKLSALPMTADILAETGIRKTVKRLRKHQHV 62
Query: 88 GSFARDLVAQWKKLVPVERNAEPDEQDFEKSNSRKRPRDALQKEEEMEGDYQETWKATGS 147
G FARDL A+WKKLV V+RN PD QD E+S SR+R +ALQ+ E+ G + E A S
Sbjct: 63 GDFARDLAARWKKLVLVDRNTGPDPQDPEESASRQRFGEALQEREKAWG-FPENATAPRS 121
Query: 148 RSYSPDHRQKKHRKLSELERPHKVSHGHERRDERKRCHRMSPTYSSDPESSDYGHVQSPP 207
S+SP+HR+ R +RPH S E R ERKR RM+P +D G + PP
Sbjct: 122 PSHSPEHRRTARRTPPGQQRPHPRSPSREPRAERKR-PRMAP--------ADSGPHRDPP 172
Query: 208 SCTSPHQMYVDHYRSLEEDQEPIVSHQKPGKGHSNAFQ--DRLGASQERHLGEPHGKGVV 265
+ T+P M E EP V ++PG+GH++A Q LG + G+P G+ V
Sbjct: 173 TRTAPLPM--------PEGPEPAVPGEQPGRGHAHAAQGGPLLGQGCQ---GQPQGEAVG 221
Query: 266 SQNKEHKSSH----KDKRPVDAKSDEKASVVSREKS 297
S +K HKSS + PV E+ + +
Sbjct: 222 SHSKGHKSSRGASAQKSPPVQESQSERLQAAGADSA 257
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 71.2 bits (173), Expect = 3e-12
Identities = 112/525 (21%), Positives = 199/525 (37%), Gaps = 40/525 (7%)
Query: 34 QVVEKLQARLAANPDPKKLLKYLKKLSTLPITVDILAETGVGKTVNSLRKHEHVGSFARD 93
+++E + R+ P P L + L K+ ++ + + +E + K V K +
Sbjct: 404 KLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKI-KVVEKSEKETVI------ 456
Query: 94 LVAQWKKLVPVERNAEPDEQDFEKSNSRKRPRDALQKEEEMEGDYQETWKATGSRSYSPD 153
+ Q ++ E E +E++ ++ ++ +EEE EG +ET + SP+
Sbjct: 457 VEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGG---EEEEAEGGEEETKSPPAEEAASPE 513
Query: 154 HRQKKHRKLSELERPHKVSHGHERRDERKRCHRMSPTYSSDPESSDYGHVQSPPSCTSPH 213
K K E + P + + E+ + + SP + P + +SPP SP
Sbjct: 514 KEAKSPVK-EEAKSPAE-AKSPEKEEAKSPAEVKSPEKAKSPAKEE---AKSPPEAKSPE 568
Query: 214 QMYVDHYRSLEEDQEPIVSHQKPGKGHSNAFQDRLGASQERHLGEPHGKGVVSQNKEHKS 273
+ ++ ++ ++ K + A S + + + +E KS
Sbjct: 569 KEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKS 628
Query: 274 SHKDKRPVDAKSDEKASVVSREKSHKALSKEENRRPPSGDNAREKPPSSGVKKEKDREGS 333
+ K P AKS K S EK+ K+ KEE + P + K P K ++ S
Sbjct: 629 PAEVKSPEKAKSPTKEEAKSPEKA-KSPEKEEAKSP-----EKAKSPVKAEAKSPEKAKS 682
Query: 334 SLKKKCLPPSEAASDNHLKKPKHRDPEKAK---LDKSKQGLDSFDTGKGAGDLLPKVKEK 390
+K + P +A S K + + PEKAK +++K + K K K
Sbjct: 683 PVKAEAKSPEKAKSP---VKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSP 739
Query: 391 GSNNLKTPEGKVKTNLDRKSLGSLPKVEETDMEDEFEQPTMSFESYLSYD-----QPRKK 445
K+PE K K+ K+L +T ++E P F + +K
Sbjct: 740 VKEEAKSPE-KAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEK 798
Query: 446 KKKIVKTSATALGDKGLKKNDSKSTGKNLDSVQ--KLPKVNKTKSEKPAGADLAKLRKVP 503
K +K A A + KK + KS K + Q K+ + K E+ A A K
Sbjct: 799 AKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKD 858
Query: 504 DVLPVLPDLPLPAIQANYRPLPSLELISSFQPKRKAFSSPQEEEE 548
P P + + P++E +PK + +EE E
Sbjct: 859 SKKEEAPKKEAPKPKVEEKKEPAVE-----KPKESKVEAKKEEAE 898
Score = 58.5 bits (140), Expect = 2e-08
Identities = 123/585 (21%), Positives = 221/585 (37%), Gaps = 67/585 (11%)
Query: 224 EEDQEPIVSHQKPGKGHSNAFQDRLGASQERHLGEPHGKGVVSQNKEHKSSHKD--KRPV 281
EE++E + ++ GK ++ +E P + S KE KS K+ K P
Sbjct: 473 EEEKE---AKEEEGKEEEGGEEEEAEGGEEETKSPP-AEEAASPEKEAKSPVKEEAKSPA 528
Query: 282 DAKSDEK------ASVVSREKSHKALSKEENRRPPSGDNA-REKPPSSGVKKEKDREGSS 334
+AKS EK A V S EK+ K+ +KEE + PP + +E+ S K ++ S
Sbjct: 529 EAKSPEKEEAKSPAEVKSPEKA-KSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSP 587
Query: 335 LKKKCLPPSEAASDNHLKKP---KHRDPEKAKLDKSKQGLDSFDTGKGAGDLLPKVKEKG 391
K++ P+EA S K P + + P +AK ++ + K K
Sbjct: 588 AKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSP-----EKAKSPT 642
Query: 392 SNNLKTPEGKVKTNLDRKSLGSLPKVEETDMEDEFEQPTMSFESYLSYDQPRKKKKKIVK 451
K+PE K K P+ ++ ++ E + P + + + +K K VK
Sbjct: 643 KEEAKSPE---KAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVK 699
Query: 452 TSATALGD-KGLKKNDSKSTGKNLDSVQKLPKV-NKTKSEKPAGADLAKLRKVPDVLPVL 509
A + K K ++KS K V++ K K KS A + K P+ L
Sbjct: 700 EEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTL 759
Query: 510 ----PDLPLPAIQANYRPLPSLELISSFQPKRKAFSSPQE-----EEEAGFTGRRMNSKM 560
P+ PA + P + P ++ SP++ +E+A + + K
Sbjct: 760 DVKSPEAKTPAKEEARSPADKFP-EKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKE 818
Query: 561 QVYSGSKCAYLPKMMTLHQQCIRVLKNNIDSIFEVGGVPYSVLEPVLERCTPDQLYRIEE 620
+V S K P+ + + + + + + + S E ++ P ++EE
Sbjct: 819 EVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKP--KVEE 876
Query: 621 YNHVLIEETDQLWKVHCHRDFKEERPE----EYESWREMYLRLQDAREQRLRVLTKNIQF 676
+E+ + KV ++ E++ + E E+ ++ ++ +++ V K
Sbjct: 877 KKEPAVEKPKES-KVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDD 935
Query: 677 AHANKPKGRQAKMAFVNSVAKPPRDVRRRQEKFGTGGAAVPEKIKIKPAPYPMGSSHASA 736
A A +P +K A A +D + + K KP P + A
Sbjct: 936 AKAKEP----SKPAEKKEAAPEKKDTKEEKAK--------------KPEEKPKTEAKAKE 977
Query: 737 SSISFNPSPEEPAYDGPSTSSAHLAPVVSSTVSYDPRKPTVKKIA 781
+ + P +P + SS+ S P K T K A
Sbjct: 978 DDKTLSKEPSKPKAEKAEKSSS-----TDQKDSKPPEKATEDKAA 1017
Score = 42.7 bits (99), Expect = 0.001
Identities = 57/269 (21%), Positives = 105/269 (39%), Gaps = 43/269 (15%)
Query: 105 ERNAEPDEQDFEKSNSRKRPRDALQKEEEMEGDYQETWKATGSRSYSPDHRQKKHRKLSE 164
E P++ K P + K+EE++ +E K + + K+ K +E
Sbjct: 791 EEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQ-------EVKVKEPPKKAE 843
Query: 165 LERPHKVSHGHERRDERKRCHRMSPTYSSDPESSDYGHVQSPPSCTSPHQMYVDHYRSLE 224
E+ E++D +K + P+ + + P+ P + V+ +
Sbjct: 844 EEKAPATPKTEEKKDSKKE--EAPKKEAPKPKVEE----KKEPAVEKPKESKVEAKKEEA 897
Query: 225 EDQEPIVSHQKPGKGHSNAFQDRLGASQERHLGEPHGKGVVSQNKEHKSSHKDKRPVDAK 284
ED++ + + +K +D +P K V++ K P DAK
Sbjct: 898 EDKKKVPTPEKEAPAKVEVKED----------AKPKEKTEVAK----------KEPDDAK 937
Query: 285 SDEKASVVSREKS--HKALSKEENRRPPSGDNAREKPPSSGVKKEKDREGSSLKKKCLPP 342
+ E + ++++ K +KEE + P EKP + KE D+ S K+ P
Sbjct: 938 AKEPSKPAEKKEAAPEKKDTKEEKAKKPE-----EKPKTEAKAKEDDKTLS--KEPSKPK 990
Query: 343 SEAASDNHLKKPKH-RDPEKAKLDKSKQG 370
+E A + K + PEKA DK+ +G
Sbjct: 991 AEKAEKSSSTDQKDSKPPEKATEDKAAKG 1019
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 60.1 bits (144), Expect = 8e-09
Identities = 77/413 (18%), Positives = 147/413 (35%), Gaps = 30/413 (7%)
Query: 83 KHEHVGSFARDLVAQWKKLVPVERNAEPDEQDFEKSNSRKRPRDALQKEEEMEGDYQETW 142
K + G F + L W++ P + D D E+ K R + ++ + +
Sbjct: 986 KDKSDGDFGKGL-EPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDKDKSEKSILE 1044
Query: 143 KATGSRSYSPDHRQKKHRKLSELERPHKVSHGHERRDERKRCHRMSPTYSSDPE--SSDY 200
K + + ++KK K HK +HG ++ + + P S D+
Sbjct: 1045 KCQKDKEFDKCFKEKKDTK-----EKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDF 1099
Query: 201 GHVQSPPSCTSPHQMYVDHYRSLEEDQEP--IVSHQKPGKGHSNAFQDRLGASQERHLGE 258
+ D + ED + S K G+ D L +E
Sbjct: 1100 SEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQEKEEGREAY 1159
Query: 259 PHGKGVVSQNKEHKSSHKDKRPVDAKSDEKASVVSREKSHKALSK-EENRRPPSGDNARE 317
+ S +K+H KDK P D + D A+ R+K K K +E + S + ++
Sbjct: 1160 ASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKD 1219
Query: 318 KPPSSGVKKEKDREGSSLKKKCLPPSEAASDNHLKKPKHRDPEKAKLDKSKQGLDSFDTG 377
+ + V +D++ + AA D K KH++ + K ++ S D
Sbjct: 1220 RKDRASVDSTQDKKNKQKLPEKAEKKHAAEDK--AKSKHKEKSDKEHSKERKSSRSADAE 1277
Query: 378 KGAGDLLPKVKEKGSNNLKTPEGKVKTNLDRKSLGSLPKVEETDMEDEFEQPTMSFESYL 437
K LL K++E+ + + S + +V D ++P ++ +
Sbjct: 1278 K---SLLEKLEEEALHEYR-----------EDSNDKISEVSSDSFTDRGQEPGLTAFLEV 1323
Query: 438 SYDQPRKKKKKIVKTSATALGDKGLKKNDSKSTGKNLDSVQKLPKVNKTKSEK 490
S+ +P K + L +K +K + + + + K K+EK
Sbjct: 1324 SFTEPPGDDK---PRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAEK 1373
Score = 42.4 bits (98), Expect = 0.002
Identities = 95/424 (22%), Positives = 147/424 (34%), Gaps = 51/424 (12%)
Query: 105 ERNAEPD-----EQDFEKSNSRKRPRDALQKEEEMEGDYQETWKATGSRSYSPDHRQKKH 159
+R EP E F + +PR++ E+++ + ++ S+ S D + K
Sbjct: 1310 DRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSSKK-SHDRERAKK 1368
Query: 160 RKLSELERPHKVSHGHERRDERKRCHRMSPTYSSD-PESSDYGHVQSPPSCTSPHQMYVD 218
K + E+ G R+D S Y D E+ YG + M D
Sbjct: 1369 EKAEKKEKGEDYKEGGSRKD--------SGQYEKDFLEADAYG---------VSYNMKAD 1411
Query: 219 HYRSLEEDQEPIVSHQKPGKGHSNAFQDRLGASQERHLGEPHGKGVVSQNKEHKSSHKDK 278
L++ E + S +K K S + E+ L +P+G ++ KE K K +
Sbjct: 1412 IEDELDKTIE-LFSTEKKDKNDSEREPSK---KIEKEL-KPYGSSAINILKEKKKREKHR 1466
Query: 279 RPVDAKSDEKASVVSREKSHKALSKEENRRPPSGDNAREKPPSSGVKKEKDREGSSLKKK 338
+ DEK R++ L + +KP + ++KD LK K
Sbjct: 1467 ---EKWRDEKER--HRDRHADGLLRHHRDELLRHHRDEQKPAT----RDKDSPPRVLKDK 1517
Query: 339 CLPPSEAASDNHLKKPKHRDPEKAKLD--KSKQGLDSFDTGKGAG--DLLPKVKEKGSNN 394
D LK+ EK K D K G D K G D P+ K G +
Sbjct: 1518 SRDEGPRLGDAKLKEKFKDGAEKEKGDPVKMSNGNDKVAPSKDPGKKDARPREKLLGDGD 1577
Query: 395 LKTPEGKVKTNLDRKSLGSLPKVEETDMEDEFEQPTMSFESYLSYDQPRKKKKKIVKTSA 454
L + T+ +R ++EE + M + S D K+K K
Sbjct: 1578 L------MMTSFERMLSQKDLEIEERHKRHKERMKQMEKLRHRSGDPKLKEKAKPADDGR 1631
Query: 455 TALGDKGLKKN---DSKSTGKNLDSVQKLPKVNKTKSEKPAGADLAKLRKVPDVLPVLPD 511
D KK D K L +P + K +GAD P + VLP
Sbjct: 1632 KKGLDIPAKKPPGLDPPFKDKKLKESTPIPPAAENKLHPASGADSKDWLAGPHMKEVLPA 1691
Query: 512 LPLP 515
P P
Sbjct: 1692 SPRP 1695
Score = 38.9 bits (89), Expect = 0.019
Identities = 82/425 (19%), Positives = 162/425 (38%), Gaps = 62/425 (14%)
Query: 126 DALQKEEEMEGDYQETWKATGSRSYSPDHRQKKHRK---LSE---------------LER 167
D+ + E DY + + S P ++++HRK LSE L++
Sbjct: 567 DSTRTRLTSESDYSS--EGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDK 624
Query: 168 PHKVSHGHERRDERKRCHRMSPTYSSDPESSDYGHVQSPPSCTSPHQMYVDHYRSLEEDQ 227
KV H+ + + K + + S + + + + S + +++ S E
Sbjct: 625 EGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKL 684
Query: 228 EPIVSHQKPGKGHSNAFQDRLGASQERHLGEPHGKGVVSQNKEHKSSHKDKRPVDAKSDE 287
+ + + K + +L + E K + NK+ S ++++ K+++
Sbjct: 685 KVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEK 744
Query: 288 KASVVSREKSHKA----LSKEENRRP----PSGDNAREKPPSSGVKKEKDR----EGSSL 335
+ S+ +EKS K L KEE ++ PS + + KEK++ + L
Sbjct: 745 ERSL--KEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFKEDKEKL 802
Query: 336 KKKCLPPSEAASDNHLKKPKHRDPEKAKLDKSKQGLDSF--DTGKGAGDLLPKVKEKGSN 393
KK+ + ++A D + K + + E K S D + D + D KG +
Sbjct: 803 KKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDF------KGED 856
Query: 394 NLKTPEGKVKTNLDRKSLGSLPKVEETDMED--------------EFEQP--TMSFESYL 437
+ +P V D KS + ET ED ++ +P YL
Sbjct: 857 SWDSP---VTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYL 913
Query: 438 SYD-QPRKKKKKIVKTSATALGDKGLKKNDSKSTGKNLDSVQKLPKVNKTKSEKPAGADL 496
+ + RK++ + K+ L +K K+ +S G++ + K + KP A
Sbjct: 914 DKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEAHR 973
Query: 497 AKLRK 501
+L++
Sbjct: 974 EELKE 978
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
[Homo sapiens]
Length = 624
Score = 56.6 bits (135), Expect = 9e-08
Identities = 68/312 (21%), Positives = 117/312 (37%), Gaps = 23/312 (7%)
Query: 130 KEEEMEGDYQETWKATGSRSYSPDHRQKKHRKLSELERPHKVSHGHER-RDERKRCHRMS 188
K E +G + + SRS S H ++K + R H S ++ R K H+
Sbjct: 299 KSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKR 358
Query: 189 PTYSSDPESSDYGHVQSPPSCTSPHQMYVDHYRSLEEDQEPIVSHQKPGKGHSNAFQDRL 248
+S H + T + + + ++E ++ + +DR
Sbjct: 359 SKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRD 418
Query: 249 GASQERHLGEPHGKGVVSQNKEH-KSSHKDKRPVDAKSDEKASVVSREKSHKALSKEENR 307
++ + + KEH K K+K K E+ S+E K +++R
Sbjct: 419 KEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSR 478
Query: 308 RPPSGDNAREKPPSSGVKKEKDREGSS---------LKKKCLPPSEAASDNHLKKPKHRD 358
PP NA + SS ++ + R SS +K+K S N KK K R+
Sbjct: 479 TPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRN--KKDKKRE 536
Query: 359 PEKAKLDKSKQGLDSFDTGKGAGDLLPKVK-EKGSNNL------KTPEGKVKTNLDRKSL 411
E+ + + ++ S K + D K K EK S +L K P+ V +D K
Sbjct: 537 KERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDK-- 594
Query: 412 GSLPKVEETDME 423
P+ EE ++
Sbjct: 595 -DAPRTEENKIQ 605
Score = 38.1 bits (87), Expect = 0.032
Identities = 44/218 (20%), Positives = 84/218 (38%), Gaps = 11/218 (5%)
Query: 116 EKSNSRKRPRDALQKEEEMEGDYQETWKATGSRSYSPDHRQKKHRKLSELERPHKVSHGH 175
EK ++R ++ +++E +E K G R+K K E +R + H
Sbjct: 382 EKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEH 441
Query: 176 ER-RDERKRCHRMSPTYSSDPESSDYGHV-QSPPSCTSPHQMYVDHYRSLEEDQEPIVSH 233
E+ RD+ K + S + + +P + Y RS +E
Sbjct: 442 EKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRE----- 496
Query: 234 QKPGKGHSNAFQDRLGASQERHLGEPHGKGVVSQNKEHKSSHKDKRPVDAKSDEKASVVS 293
++ + S++ R + +R S+NK+ K K++ + + + + S
Sbjct: 497 RRRRRSRSSSRSPRTSKTIKRK--SSRSPSPRSRNKKDKKREKERDHISERRERERSTSM 554
Query: 294 REKSHKALSKEENRRPPSGDNARE--KPPSSGVKKEKD 329
R+ S+ KE+ + + +E K P S V KE D
Sbjct: 555 RKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVD 592
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
[Homo sapiens]
Length = 508
Score = 56.6 bits (135), Expect = 9e-08
Identities = 68/312 (21%), Positives = 117/312 (37%), Gaps = 23/312 (7%)
Query: 130 KEEEMEGDYQETWKATGSRSYSPDHRQKKHRKLSELERPHKVSHGHER-RDERKRCHRMS 188
K E +G + + SRS S H ++K + R H S ++ R K H+
Sbjct: 183 KSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKR 242
Query: 189 PTYSSDPESSDYGHVQSPPSCTSPHQMYVDHYRSLEEDQEPIVSHQKPGKGHSNAFQDRL 248
+S H + T + + + ++E ++ + +DR
Sbjct: 243 SKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRD 302
Query: 249 GASQERHLGEPHGKGVVSQNKEH-KSSHKDKRPVDAKSDEKASVVSREKSHKALSKEENR 307
++ + + KEH K K+K K E+ S+E K +++R
Sbjct: 303 KEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSR 362
Query: 308 RPPSGDNAREKPPSSGVKKEKDREGSS---------LKKKCLPPSEAASDNHLKKPKHRD 358
PP NA + SS ++ + R SS +K+K S N KK K R+
Sbjct: 363 TPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRN--KKDKKRE 420
Query: 359 PEKAKLDKSKQGLDSFDTGKGAGDLLPKVK-EKGSNNL------KTPEGKVKTNLDRKSL 411
E+ + + ++ S K + D K K EK S +L K P+ V +D K
Sbjct: 421 KERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDK-- 478
Query: 412 GSLPKVEETDME 423
P+ EE ++
Sbjct: 479 -DAPRTEENKIQ 489
Score = 38.1 bits (87), Expect = 0.032
Identities = 44/218 (20%), Positives = 84/218 (38%), Gaps = 11/218 (5%)
Query: 116 EKSNSRKRPRDALQKEEEMEGDYQETWKATGSRSYSPDHRQKKHRKLSELERPHKVSHGH 175
EK ++R ++ +++E +E K G R+K K E +R + H
Sbjct: 266 EKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEH 325
Query: 176 ER-RDERKRCHRMSPTYSSDPESSDYGHV-QSPPSCTSPHQMYVDHYRSLEEDQEPIVSH 233
E+ RD+ K + S + + +P + Y RS +E
Sbjct: 326 EKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRE----- 380
Query: 234 QKPGKGHSNAFQDRLGASQERHLGEPHGKGVVSQNKEHKSSHKDKRPVDAKSDEKASVVS 293
++ + S++ R + +R S+NK+ K K++ + + + + S
Sbjct: 381 RRRRRSRSSSRSPRTSKTIKRK--SSRSPSPRSRNKKDKKREKERDHISERRERERSTSM 438
Query: 294 REKSHKALSKEENRRPPSGDNARE--KPPSSGVKKEKD 329
R+ S+ KE+ + + +E K P S V KE D
Sbjct: 439 RKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVD 476
>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sapiens]
Length = 1792
Score = 54.3 bits (129), Expect = 4e-07
Identities = 109/495 (22%), Positives = 183/495 (36%), Gaps = 80/495 (16%)
Query: 85 EHVGSFARDLVAQWKKLVPVERNAEPDEQDFEKSNSRKRPRDALQKEEE---MEGDYQET 141
E FA++L+ ++KK+ R + + +S R K Y +
Sbjct: 660 EFTNDFAKELM-EYKKIQKERRRSFSRSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRS 718
Query: 142 WKATGSRSYS--PDHRQKKHRKLSELERPHKVSHGHERRDERKRCHRMSPTYSSDPESSD 199
+ + SRSYS P + ++ K S R SHG+ R R +R + S P++
Sbjct: 719 FSRSHSRSYSRSPPYPRRGRGK-SRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAF- 776
Query: 200 YGHVQSPPSCTSPH----QMYVDHYRSLEEDQEPIVSHQKPGKGHSNAFQD-------RL 248
QSP P + Y + YR + P K G S F+D R
Sbjct: 777 --RGQSPNKRNVPQGETEREYFNRYREV-----PPPYDMKAYYGRSVDFRDPFEKERYRE 829
Query: 249 GASQERHLGEPHGKGVVSQNKEHKSSHKDKRPVDA--KSDEKASVVSREKSHKALSKEEN 306
+ R E + KG + + S++++ + + + S +R + + + +
Sbjct: 830 WERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQSH 889
Query: 307 RRPPSGDNAREKPPSSGVKKEKDREGSSLKKKCLPPSEAASDNHLKKPKHRDPEKAKLDK 366
R G N EK + +KD S K+ P + + H K K R E+++
Sbjct: 890 RSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESE--- 946
Query: 367 SKQGLDSFDTGKGAGDLLPKVKEKGSNNLKTPEGKVKTNLDRKSLGSLPKVEE-TDMEDE 425
G L P++ E S + P G + D SL LP ++ T + DE
Sbjct: 947 --------------GFLNPELLET-SRKSREPTGVEENKTD--SLFVLPSRDDATPVRDE 989
Query: 426 -FEQPTMSFESYLSYDQPRKKKKKIVKTSATALGDKGLKKNDSKSTGKNLDSVQKLPKVN 484
+ +++F+S D+ + K K A GDK +KND + K + + K
Sbjct: 990 PMDAESITFKSVSEKDKRERDKPK-------AKGDKTKRKNDGSAVSKK----ENIVKPA 1038
Query: 485 KTKSEKPAGADLAKLRKVPDVLPVLPDLPLPAIQANYRPLPSLELISSFQPKRKAFSSPQ 544
K EK G R P + + P K+ SS Q
Sbjct: 1039 KGPQEKVDGERERSPRSEPPIKKAKEETPK-------------------TDNTKSSSSSQ 1079
Query: 545 EEEEAGFTGRRMNSK 559
++E+ T R+ +SK
Sbjct: 1080 KDEKITGTPRKAHSK 1094
Score = 53.1 bits (126), Expect = 1e-06
Identities = 88/404 (21%), Positives = 153/404 (37%), Gaps = 69/404 (17%)
Query: 105 ERNAEPD-EQDFEKSNSRKRPRDALQKEEEME-GDYQETWKATGSRSYSPDHRQKKHRKL 162
+ + +P+ E + ++ N + + Q +E D ++ +A+ ++ ++P+ +K
Sbjct: 1420 KNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDT 1479
Query: 163 SELERPHKVSHGHERRDERKRCHRMSPTYSSDPESSDYGHVQSPPSCTSPHQMYVDHYRS 222
E +RRDE+ R + S + +S+
Sbjct: 1480 REYS-------SSKRRDEKNELTRRKDSPSRNKDSAS----------------------- 1509
Query: 223 LEEDQEPIVSHQKPGKGHSNAFQDRLGASQERHLGEPHGKGVVSQNKEHKSSHKDKRP-V 281
+ +P P KG ++ + S++R +PH +HK+++ KRP
Sbjct: 1510 -GQKNKPREERDLPKKGTGDSKKSNSSPSRDR---KPH---------DHKATYDTKRPNE 1556
Query: 282 DAKSDEKASVVSREKSHKALSKEENRRPPSGDNARE--KPPSSGVKKEKDREGSSLKKKC 339
+ KS +K REK + + N + SG+ PP + V+KE+ G K
Sbjct: 1557 ETKSVDKNPCKDREKH---VLEARNNKESSGNKLLYILNPPETQVEKEQIT-GQIDKSTV 1612
Query: 340 LPPSEAASDNHLKKPKHRDPEKAKLDKSKQGLDSFD---------TGKGAGDLLPKVKEK 390
P + + + L R+ ++A + DS +G + DL K+ EK
Sbjct: 1613 KPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEK 1672
Query: 391 GSNNLKTPEGKVKTNLDRKSLGSLPKVEETDMEDEFEQPTMSFESYLS----YDQPRKKK 446
+L T V+ + R S P V + T S S S D +KKK
Sbjct: 1673 AKESLDTA-AVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKK 1731
Query: 447 KKIVKTSATALGDKGLKKNDSKSTGKNLDSVQKLPKVNKTKSEK 490
KK K K KK+ T L+ QK K K KS+K
Sbjct: 1732 KKEKKKHKKHKKHKKHKKH--AGTEVELEKSQK-HKHKKKKSKK 1772
Score = 43.1 bits (100), Expect = 0.001
Identities = 62/277 (22%), Positives = 105/277 (37%), Gaps = 62/277 (22%)
Query: 235 KPGKGHSNAFQDRLGASQERHLGEPHGKGVVSQNKEHK-SSHKDKRPVDAKSDEKASVVS 293
KP KG Q+++ +ER P + + + KE + K ++ DEK +
Sbjct: 1036 KPAKGP----QEKVDGERER---SPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTP 1088
Query: 294 REKSHKALSKEENRRPPSGDNAREKPPSSGVKKEKDREGSSLKKKCLPPSEAASDNHLKK 353
R K+H +KE P + +K S VK EK L K +A N K
Sbjct: 1089 R-KAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEK------LTTK---EEKAKKPNEKNK 1138
Query: 354 PKHRDPEKAKLDKSKQGLD-SFDTG---------------------KGAGDLLPKVKEKG 391
P EK K ++G+D F++ + + + + EK
Sbjct: 1139 PLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKD 1198
Query: 392 SNNLKTPEGKVKTNLDR-KSLGSLPKVEETDMEDEFEQPTMSFESYLSYDQPRKKKKKIV 450
+L P K+K N + K +GS + T ++P+ ES S + K K K+
Sbjct: 1199 KISLSAPAKKIKLNRETGKKIGSTENISNT------KEPSEKLESTSSKVKQEKVKGKVR 1252
Query: 451 K---------------TSATALGDKGLKKNDSKSTGK 472
+ TS ++ G ++K++ K+ K
Sbjct: 1253 RKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTK 1289
Score = 37.7 bits (86), Expect = 0.042
Identities = 47/283 (16%), Positives = 101/283 (35%), Gaps = 25/283 (8%)
Query: 106 RNAEPDEQDFEKSNSRKRPRDALQKEEEMEGDYQETWKATGSRSYSPDHRQKKHRKLSEL 165
R P S + +PR+ ++ GD +++ + S S D + H+ +
Sbjct: 1497 RKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKS-----NSSPSRDRKPHDHKATYDT 1551
Query: 166 ERPHKVSHGHERRDERKR-CHRMSPTYSSDPESSDYGHVQSPPSCTSPHQMYVDHYRSLE 224
+RP++ + ++ + R H + + + + ++ +PP +
Sbjct: 1552 KRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKST 1611
Query: 225 EDQEPIVSHQK------PGKGHSNAFQDRLGASQERH---LGEPHGKGVVSQNKEHKSSH 275
+P +SH + AF+ S + E G +S++ + K
Sbjct: 1612 VKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVE 1671
Query: 276 KDKRPVDAKSDEKASV----------VSREKSHKALSKEENRRPPSGDNAREKPPSSGVK 325
K K +D + + + VS +SH + S +A + K
Sbjct: 1672 KAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKK 1731
Query: 326 KEKDREGSSLKKKCLPPSEAASDNHLKKPKHRDPEKAKLDKSK 368
K++ ++ KK A ++ L+K + +K K K+K
Sbjct: 1732 KKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNK 1774
Score = 36.2 bits (82), Expect = 0.12
Identities = 66/316 (20%), Positives = 120/316 (37%), Gaps = 56/316 (17%)
Query: 225 EDQEPIVSHQKPGKGHSNAFQDRLGASQERHLGEPHGKGVVSQNKEHKSSHK-------D 277
+D++ V ++ + N+ Q ++ +R + + K + +KE ++S K
Sbjct: 1404 KDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASS 1463
Query: 278 KRPVDAKSDEKASVVSREKSHKALSKEENRRPPSGDNAREKPPSSGVKKEKDREGSSLKK 337
+ D+K +RE S E+N D+ S+ +K K RE L K
Sbjct: 1464 NKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPK 1523
Query: 338 KCLPPSEA--ASDNHLKKP---------KHRDPEKAKLDKS------KQGLDSFDTGKGA 380
K S+ +S + +KP K + E +DK+ K L++ + + +
Sbjct: 1524 KGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESS 1583
Query: 381 GDLLPKV---------KEKGSNNLKTPEGKVKTNLDRKSLGSLPKVEETD--------ME 423
G+ L + KE+ + + K K L S S ETD E
Sbjct: 1584 GNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNE 1643
Query: 424 DEFEQPTMSFESYLSYDQPRKKKKKIVKTS-----ATALGDKGLKKNDSKSTGKNLDSVQ 478
+ E E S + + K KIV+ + A+ G+ +N S S+
Sbjct: 1644 SDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSS-------- 1695
Query: 479 KLPKVNKTKSEKPAGA 494
P V+ ++S P+G+
Sbjct: 1696 --PSVSPSRSHSPSGS 1709
Score = 30.8 bits (68), Expect = 5.2
Identities = 24/98 (24%), Positives = 38/98 (38%), Gaps = 18/98 (18%)
Query: 266 SQNKEHKSSHKDKRPVDAKSDEKASVVSREKSHKALSKEENRRPPSGDNAREKPPSSGVK 325
SQ + H SS D+K +K + K HK K +K + V+
Sbjct: 1709 SQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKK------------HKKHAGTEVE 1756
Query: 326 KEKDREGSSLKKKCLPPSEAASDNHLKKPKHRDPEKAK 363
EK ++ KKK + + +K K +D +K K
Sbjct: 1757 LEKSQKHKHKKKK------SKKNKDKEKEKEKDDQKVK 1788
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 53.5 bits (127), Expect = 7e-07
Identities = 54/232 (23%), Positives = 90/232 (38%), Gaps = 32/232 (13%)
Query: 195 PESSDYGHVQSPPSCTSPHQMYVDHYRSLEEDQEPIVSHQK-PGKGHSNAFQDRLGASQE 253
PE + HV+ PP S ++ V + ++ + +P V+ ++ P K + + + Q
Sbjct: 566 PEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQA 625
Query: 254 RHLGEPHGKGVVSQNKEHKSSHKDKRPVD-------AKSDEKASVVSREKSHKALSKEE- 305
+ +P + KE K +DK+ AK ++K + EK K K+E
Sbjct: 626 TDV-KPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEV 684
Query: 306 -------NRRPPSGDNAREKPPSSGVKKEKDREGSSLKK---------KCLPPSEAASDN 349
++ P + +E PP K+ K E +KK K LP S
Sbjct: 685 KKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSST 744
Query: 350 HLKKPKHRDPEKAKLDKSKQGLDSFDTGKGAGDLLPKVKEKGSNNLKTPEGK 401
L + K K K+ K ++ + G K KEKG + EGK
Sbjct: 745 PLSEAKKPAALKPKVPKKEESVKKDSVAAG------KPKEKGKIKVIKKEGK 790
Score = 37.0 bits (84), Expect = 0.072
Identities = 56/244 (22%), Positives = 96/244 (39%), Gaps = 38/244 (15%)
Query: 283 AKSDEKASVVSREKSHKALSKEENRRPPSGD--NAREKPPSSGVKKEKDREGSSLKK-KC 339
A S E ++ K++ KE P N EKPP K + +E +KK K
Sbjct: 539 ADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPP-----KVESKEKVMVKKDKP 593
Query: 340 LPPSEAASDNHLKKPKHRDPEKAKLDKSKQGLDSFDTGKGAGDLLPKVKEKGSNNLKTPE 399
+ S + P +P K + ++ K A D+ PK ++ + +T
Sbjct: 594 IKTETKPSVTEKEVPSKEEPSPVKAEVAE---------KQATDVKPKAAKEKTVKKET-- 642
Query: 400 GKVKTNLDRKSLGSLPKVEETDMEDEF----------EQPTMSFESYLSYDQPRKKKKKI 449
KVK D+K PK E ED+ E+ + + ++ ++ KK++
Sbjct: 643 -KVKPE-DKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEV 700
Query: 450 VKTSATALGDKGLKKNDSKSTGKNLDSVQKLPK--VNK-TKSEKPAGADLAKLRKVPDVL 506
K + K +KK + K K +K PK + K K K + L++ +K +
Sbjct: 701 KKETPPKEVKKEVKKEEKKEVKKE----EKEPKKEIKKLPKDAKKSSTPLSEAKKPAALK 756
Query: 507 PVLP 510
P +P
Sbjct: 757 PKVP 760
Score = 32.0 bits (71), Expect = 2.3
Identities = 37/149 (24%), Positives = 62/149 (41%), Gaps = 19/149 (12%)
Query: 363 KLDKSKQGLDSFDTGKGAGDLLPKVKEKGSNNLKTPEGKVKTNLDRKSLGSLPKVE---- 418
K K KQ DS ++ K A LP + + +TPE ++++ PKVE
Sbjct: 531 KQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKP-----PKVESKEK 585
Query: 419 ---ETDMEDEFE-QPTMSFESYLSYDQPRKKKKKIVKTSATALGDKGLKKNDSKSTGKNL 474
+ D + E +P+++ + S ++P K ++ + AT + K K+ K K
Sbjct: 586 VMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETK-- 643
Query: 475 DSVQKLPKVNKTKSEKPAGADLAKLRKVP 503
P+ K + EKP K K P
Sbjct: 644 ----VKPEDKKEEKEKPKKEVAKKEDKTP 668
>gi|125656165 THO complex 2 [Homo sapiens]
Length = 1593
Score = 53.1 bits (126), Expect = 1e-06
Identities = 68/321 (21%), Positives = 125/321 (38%), Gaps = 27/321 (8%)
Query: 105 ERNAEPDEQDFEKS-----NSRKRPRDALQKEEEMEGDYQETWKATGSRSYSPDHRQKKH 159
E+ E +++ EK+ +R +D +K +E + E + T R+ D ++K
Sbjct: 1272 EKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKF 1331
Query: 160 RKLSELER-------PHKVSHGHERRDERKRCHRMSPTYSSDPESSDY-GHVQSPPSCTS 211
+K + + P+ S + R+ K R + G ++P S +
Sbjct: 1332 KKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSGSL 1391
Query: 212 PHQMYVDHYRSLEEDQEPIVSHQKPGKGHSNAFQDRLGASQERHLGEPHGKGVVSQNKEH 271
+ E +Q+ P HS+ +D L L E K ++
Sbjct: 1392 KSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSL-----IELKESSAKLYINHTPPP 1446
Query: 272 KSSHKDKRPVDAKSDEKASVVSREKSHKALSKEENRRPPSGDNAREKPPSSGVKKEKDRE 331
S K+ R +D K +K+ SRE+ K + R+ +N RE PP K+ K+
Sbjct: 1447 LSKSKE-REMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDL-TKRRKEEN 1504
Query: 332 GSSLKKKCLPPSEAASDNHLKKPKHRDPEKAKLDKSKQGLDSFDTGKGAGDLLPKVKEKG 391
G+ K SE+ ++ K ++ K+K ++G DSF + K + K+ G
Sbjct: 1505 GTMGVSK--HKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEK-----MDKISSGG 1557
Query: 392 SNNLKTPEGKVKTNLDRKSLG 412
+ + K++ R S G
Sbjct: 1558 KKESRHDKEKIEKKEKRDSSG 1578
Score = 46.2 bits (108), Expect = 1e-04
Identities = 64/263 (24%), Positives = 110/263 (41%), Gaps = 22/263 (8%)
Query: 249 GASQERHLGEPHGKGVVSQNKEH-KSSHKDKRPVDAKSDEKASVVSREKSHKALSKEENR 307
G S + G K V +KE K K+K+ + +A V+ ++ K KEE
Sbjct: 1251 GNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKP--KEE-- 1306
Query: 308 RPPSGDNARE---KPPSSGVKKEKDREGSSLK----KKCLPPSEAASDNHLKKPKH--RD 358
RP + ARE + P S +KEK ++ K K +P +E+ S ++ K R+
Sbjct: 1307 RPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRE 1366
Query: 359 PEKAKLDKSKQGLDSFDTGKGAGDLLPKVKEKGSNNLKTPEGKVKTNLDRKSLGSLPKVE 418
+ AK KSK+ + + +G L V +++ PE + K + P
Sbjct: 1367 RDIAKEMKSKENVKGGEKTPVSGSLKSPVPR---SDIPEPEREQKRR--KIDTHPSPSHS 1421
Query: 419 ETDMEDEFEQPTMSFESYLSYDQPRKKKKKIVKTSATALGDKGLKKNDSKSTGKNLDSVQ 478
T + E S + Y+++ P K K + L DK ++ S+ K + +
Sbjct: 1422 STVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDL-DKSRER--SREREKKDEKDR 1478
Query: 479 KLPKVNKTKSEKPAGADLAKLRK 501
K K + + +++ DL K RK
Sbjct: 1479 KERKRDHSNNDREVPPDLTKRRK 1501
Score = 38.5 bits (88), Expect = 0.025
Identities = 64/267 (23%), Positives = 107/267 (40%), Gaps = 39/267 (14%)
Query: 97 QWKKLVPVERNAEPDEQDFEKSNSRKRP--RDALQKEEEMEGD---YQETWKATGSRSYS 151
++K VP + E++ EK SR+R ++ KE G+ + K+ RS
Sbjct: 1341 KFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDI 1400
Query: 152 PD-HRQKKHRKLSELERPHKVSHGHERRDERKRCHRMSPTYSSDPESSDYGHVQ-SPPSC 209
P+ R++K RK+ P S + E K ESS ++ +PP
Sbjct: 1401 PEPEREQKRRKIDTHPSPSHSSTVKDSLIELK-------------ESSAKLYINHTPPPL 1447
Query: 210 TSPHQMYVD-------HYRSLEEDQEPIVSHQKPGKGHSNAFQDRLGASQERHLGEPHGK 262
+ + +D RS E +++ ++ + HSN ++ + + E +G
Sbjct: 1448 SKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDRE-VPPDLTKRRKEENGT 1506
Query: 263 GVVSQNKEHKS------SHKDKRPVDAKSDEKASVVSREKSHK-----ALSKEENRRPPS 311
VS++K + KDK +KS K KS K + K+E+R
Sbjct: 1507 MGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKE 1566
Query: 312 GDNAREKPPSSGVKKEKDREGSSLKKK 338
+EK SSG K+EK SS K +
Sbjct: 1567 KIEKKEKRDSSGGKEEKKHHKSSDKHR 1593
Score = 37.7 bits (86), Expect = 0.042
Identities = 41/183 (22%), Positives = 64/183 (34%), Gaps = 14/183 (7%)
Query: 257 GEPHGKGVVSQNKEHKSSHKDKRPVDAKSDEKASVVSREKSHKALSKEENRRPPSGDNAR 316
G P + S +K +SS ++ +S V++ S N S N
Sbjct: 1206 GGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKA 1265
Query: 317 EKPPSSGVKKEKDREGSSLKKKCLPPSEAASDNHLKKPKHRDPEK-AKLDKSKQGLDSFD 375
K KEK++E P + + +KPK P K K ++K+ D
Sbjct: 1266 VKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSD 1325
Query: 376 TGKGAGDLLPKVKEKGSNNLKTPEGKVKT---NLDRKSLGSLPKVEETDMEDEFEQPTMS 432
K KEK K + K KT N + KS + +E E + + S
Sbjct: 1326 ----------KEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKS 1375
Query: 433 FES 435
E+
Sbjct: 1376 KEN 1378
>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sapiens]
Length = 1758
Score = 53.1 bits (126), Expect = 1e-06
Identities = 88/404 (21%), Positives = 153/404 (37%), Gaps = 69/404 (17%)
Query: 105 ERNAEPD-EQDFEKSNSRKRPRDALQKEEEME-GDYQETWKATGSRSYSPDHRQKKHRKL 162
+ + +P+ E + ++ N + + Q +E D ++ +A+ ++ ++P+ +K
Sbjct: 1386 KNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDT 1445
Query: 163 SELERPHKVSHGHERRDERKRCHRMSPTYSSDPESSDYGHVQSPPSCTSPHQMYVDHYRS 222
E +RRDE+ R + S + +S+
Sbjct: 1446 REYS-------SSKRRDEKNELTRRKDSPSRNKDSAS----------------------- 1475
Query: 223 LEEDQEPIVSHQKPGKGHSNAFQDRLGASQERHLGEPHGKGVVSQNKEHKSSHKDKRP-V 281
+ +P P KG ++ + S++R +PH +HK+++ KRP
Sbjct: 1476 -GQKNKPREERDLPKKGTGDSKKSNSSPSRDR---KPH---------DHKATYDTKRPNE 1522
Query: 282 DAKSDEKASVVSREKSHKALSKEENRRPPSGDNARE--KPPSSGVKKEKDREGSSLKKKC 339
+ KS +K REK + + N + SG+ PP + V+KE+ G K
Sbjct: 1523 ETKSVDKNPCKDREKH---VLEARNNKESSGNKLLYILNPPETQVEKEQIT-GQIDKSTV 1578
Query: 340 LPPSEAASDNHLKKPKHRDPEKAKLDKSKQGLDSFD---------TGKGAGDLLPKVKEK 390
P + + + L R+ ++A + DS +G + DL K+ EK
Sbjct: 1579 KPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEK 1638
Query: 391 GSNNLKTPEGKVKTNLDRKSLGSLPKVEETDMEDEFEQPTMSFESYLS----YDQPRKKK 446
+L T V+ + R S P V + T S S S D +KKK
Sbjct: 1639 AKESLDTA-AVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKK 1697
Query: 447 KKIVKTSATALGDKGLKKNDSKSTGKNLDSVQKLPKVNKTKSEK 490
KK K K KK+ T L+ QK K K KS+K
Sbjct: 1698 KKEKKKHKKHKKHKKHKKH--AGTEVELEKSQK-HKHKKKKSKK 1738
Score = 51.6 bits (122), Expect = 3e-06
Identities = 99/439 (22%), Positives = 164/439 (37%), Gaps = 76/439 (17%)
Query: 138 YQETWKATGSRSYS--PDHRQKKHRKLSELERPHKVSHGHERRDERKRCHRMSPTYSSDP 195
Y ++ + SRSYS P + ++ K S R SHG+ R R +R + S P
Sbjct: 681 YSRSFSRSHSRSYSRSPPYPRRGRGK-SRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSP 739
Query: 196 ESSDYGHVQSPPSCTSPH----QMYVDHYRSLEEDQEPIVSHQKPGKGHSNAFQD----- 246
++ QSP P + Y + YR + P K G S F+D
Sbjct: 740 QAF---RGQSPNKRNVPQGETEREYFNRYREV-----PPPYDMKAYYGRSVDFRDPFEKE 791
Query: 247 --RLGASQERHLGEPHGKGVVSQNKEHKSSHKDKRPVDA--KSDEKASVVSREKSHKALS 302
R + R E + KG + + S++++ + + + S +R + +
Sbjct: 792 RYREWERKYREWYEKYYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVG 851
Query: 303 KEENRRPPSGDNAREKPPSSGVKKEKDREGSSLKKKCLPPSEAASDNHLKKPKHRDPEKA 362
+ +R G N EK + +KD S K+ P + + H K K R E++
Sbjct: 852 GQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEES 911
Query: 363 KLDKSKQGLDSFDTGKGAGDLLPKVKEKGSNNLKTPEGKVKTNLDRKSLGSLPKVEE-TD 421
+ G L P++ E S + P G + D SL LP ++ T
Sbjct: 912 E-----------------GFLNPELLET-SRKSREPTGVEENKTD--SLFVLPSRDDATP 951
Query: 422 MEDE-FEQPTMSFESYLSYDQPRKKKKKIVKTSATALGDKGLKKNDSKSTGKNLDSVQKL 480
+ DE + +++F+S D+ + K K A GDK +KND + K + +
Sbjct: 952 VRDEPMDAESITFKSVSEKDKRERDKPK-------AKGDKTKRKNDGSAVSKK----ENI 1000
Query: 481 PKVNKTKSEKPAGADLAKLRKVPDVLPVLPDLPLPAIQANYRPLPSLELISSFQPKRKAF 540
K K EK G R P + + P K+
Sbjct: 1001 VKPAKGPQEKVDGERERSPRSEPPIKKAKEETPK-------------------TDNTKSS 1041
Query: 541 SSPQEEEEAGFTGRRMNSK 559
SS Q++E+ T R+ +SK
Sbjct: 1042 SSSQKDEKITGTPRKAHSK 1060
Score = 43.1 bits (100), Expect = 0.001
Identities = 62/277 (22%), Positives = 105/277 (37%), Gaps = 62/277 (22%)
Query: 235 KPGKGHSNAFQDRLGASQERHLGEPHGKGVVSQNKEHK-SSHKDKRPVDAKSDEKASVVS 293
KP KG Q+++ +ER P + + + KE + K ++ DEK +
Sbjct: 1002 KPAKGP----QEKVDGERER---SPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTP 1054
Query: 294 REKSHKALSKEENRRPPSGDNAREKPPSSGVKKEKDREGSSLKKKCLPPSEAASDNHLKK 353
R K+H +KE P + +K S VK EK L K +A N K
Sbjct: 1055 R-KAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEK------LTTK---EEKAKKPNEKNK 1104
Query: 354 PKHRDPEKAKLDKSKQGLD-SFDTG---------------------KGAGDLLPKVKEKG 391
P EK K ++G+D F++ + + + + EK
Sbjct: 1105 PLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKD 1164
Query: 392 SNNLKTPEGKVKTNLDR-KSLGSLPKVEETDMEDEFEQPTMSFESYLSYDQPRKKKKKIV 450
+L P K+K N + K +GS + T ++P+ ES S + K K K+
Sbjct: 1165 KISLSAPAKKIKLNRETGKKIGSTENISNT------KEPSEKLESTSSKVKQEKVKGKVR 1218
Query: 451 K---------------TSATALGDKGLKKNDSKSTGK 472
+ TS ++ G ++K++ K+ K
Sbjct: 1219 RKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTK 1255
Score = 37.7 bits (86), Expect = 0.042
Identities = 47/283 (16%), Positives = 101/283 (35%), Gaps = 25/283 (8%)
Query: 106 RNAEPDEQDFEKSNSRKRPRDALQKEEEMEGDYQETWKATGSRSYSPDHRQKKHRKLSEL 165
R P S + +PR+ ++ GD +++ + S S D + H+ +
Sbjct: 1463 RKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKS-----NSSPSRDRKPHDHKATYDT 1517
Query: 166 ERPHKVSHGHERRDERKR-CHRMSPTYSSDPESSDYGHVQSPPSCTSPHQMYVDHYRSLE 224
+RP++ + ++ + R H + + + + ++ +PP +
Sbjct: 1518 KRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKST 1577
Query: 225 EDQEPIVSHQK------PGKGHSNAFQDRLGASQERH---LGEPHGKGVVSQNKEHKSSH 275
+P +SH + AF+ S + E G +S++ + K
Sbjct: 1578 VKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVE 1637
Query: 276 KDKRPVDAKSDEKASV----------VSREKSHKALSKEENRRPPSGDNAREKPPSSGVK 325
K K +D + + + VS +SH + S +A + K
Sbjct: 1638 KAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKK 1697
Query: 326 KEKDREGSSLKKKCLPPSEAASDNHLKKPKHRDPEKAKLDKSK 368
K++ ++ KK A ++ L+K + +K K K+K
Sbjct: 1698 KKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNK 1740
Score = 36.2 bits (82), Expect = 0.12
Identities = 66/316 (20%), Positives = 120/316 (37%), Gaps = 56/316 (17%)
Query: 225 EDQEPIVSHQKPGKGHSNAFQDRLGASQERHLGEPHGKGVVSQNKEHKSSHK-------D 277
+D++ V ++ + N+ Q ++ +R + + K + +KE ++S K
Sbjct: 1370 KDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASS 1429
Query: 278 KRPVDAKSDEKASVVSREKSHKALSKEENRRPPSGDNAREKPPSSGVKKEKDREGSSLKK 337
+ D+K +RE S E+N D+ S+ +K K RE L K
Sbjct: 1430 NKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPK 1489
Query: 338 KCLPPSEA--ASDNHLKKP---------KHRDPEKAKLDKS------KQGLDSFDTGKGA 380
K S+ +S + +KP K + E +DK+ K L++ + + +
Sbjct: 1490 KGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESS 1549
Query: 381 GDLLPKV---------KEKGSNNLKTPEGKVKTNLDRKSLGSLPKVEETD--------ME 423
G+ L + KE+ + + K K L S S ETD E
Sbjct: 1550 GNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNE 1609
Query: 424 DEFEQPTMSFESYLSYDQPRKKKKKIVKTS-----ATALGDKGLKKNDSKSTGKNLDSVQ 478
+ E E S + + K KIV+ + A+ G+ +N S S+
Sbjct: 1610 SDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSS-------- 1661
Query: 479 KLPKVNKTKSEKPAGA 494
P V+ ++S P+G+
Sbjct: 1662 --PSVSPSRSHSPSGS 1675
Score = 30.8 bits (68), Expect = 5.2
Identities = 24/98 (24%), Positives = 38/98 (38%), Gaps = 18/98 (18%)
Query: 266 SQNKEHKSSHKDKRPVDAKSDEKASVVSREKSHKALSKEENRRPPSGDNAREKPPSSGVK 325
SQ + H SS D+K +K + K HK K +K + V+
Sbjct: 1675 SQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKK------------HKKHAGTEVE 1722
Query: 326 KEKDREGSSLKKKCLPPSEAASDNHLKKPKHRDPEKAK 363
EK ++ KKK + + +K K +D +K K
Sbjct: 1723 LEKSQKHKHKKKK------SKKNKDKEKEKEKDDQKVK 1754
>gi|239757016 PREDICTED: similar to RNA polymerase II transcription
factor SIII subunit A3, partial [Homo sapiens]
Length = 78
Score = 52.8 bits (125), Expect = 1e-06
Identities = 33/88 (37%), Positives = 47/88 (53%), Gaps = 10/88 (11%)
Query: 711 TGGAAVPEKIKIKPAPYPMGSSHASASSISFNPSPEEPAYDGPSTSSAHLAPVVSSTVSY 770
+ GAA P +++PAP P GSS A + + + G +S+ H AP +
Sbjct: 1 SAGAADPGNGEMEPAPKPAGSSQAPSGL----GDGDGGSGSGGGSSNRHAAPADKT---- 52
Query: 771 DPRKPTVKKIAPMMAKTIKAFKNRFSRR 798
RK KK+AP+MAK I+ +K RFSRR
Sbjct: 53 --RKQAAKKVAPLMAKAIRDYKGRFSRR 78
>gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [Homo
sapiens]
Length = 3969
Score = 52.4 bits (124), Expect = 2e-06
Identities = 93/402 (23%), Positives = 157/402 (39%), Gaps = 59/402 (14%)
Query: 144 ATGSRSYSPDHRQKKHRKLSELE-RPHKVSHGHERRDERKRCHRMSPTYSSDPESSDYGH 202
+ G+ S +R++K + S + P SH R R +SP SS
Sbjct: 723 SAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSLSI 782
Query: 203 VQSPPSCTSPHQMYVDHYRSLEEDQEPIVSHQKPGKGHSNAFQDRLGASQERHLGEPHGK 262
SP + ++ + + SL + E +Q+P K ++A + +S L
Sbjct: 783 SVSPLATSALNPTFTFPSHSLTQSGESAEKNQRPRK-QTSAPAEPFSSSSPTPLFPWFTP 841
Query: 263 GVVSQNKEHKSSHKDKRPVDAKSDEKASVVSREKSHKALSKEENRRPPSGDNAREKPPSS 322
G ++ + +KDK P + D A K++ K+++R D REK
Sbjct: 842 G----SQTERGRNKDKAPEELSKDRDAD--------KSVEKDKSR---ERDREREKENKR 886
Query: 323 GVKKEKDREGSSLK------------KKCLPPSEAASDNHLKKPKHRDPEKAKLDKSKQG 370
+KEK ++GS ++ K+ + + A+ + KK R +K+ S
Sbjct: 887 ESRKEKRKKGSEIQSSSALYPVGRVSKEKVVGEDVATSSSAKKATGR--KKSSSHDSGTD 944
Query: 371 LDSFDTGKGAGDLLPKVKEKGSNNLKTPEGKVKTNLDRKSLG-SLPKVEE-------TDM 422
+ S G + +KG NL+ KTNLD LG + P +E+ T
Sbjct: 945 ITSVTLGDTTAVKTKILIKKGRGNLE------KTNLD---LGPTAPSLEKEKTLCLSTPS 995
Query: 423 EDEFEQPTMSFESYLS----YDQPRKKKKKIVKTSATAL----GDKGLKKNDS-KSTGKN 473
+ T S S L+ K+ ++K + L K LK+ D K+ G+
Sbjct: 996 SSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQE 1055
Query: 474 LDSVQKLPKVNKTKSE-KPAGADLAKLRKV-PDVLPVLPDLP 513
DS + + + K + A L + R V PD +P L LP
Sbjct: 1056 SDSSETSVRGPRIKHVCRRAAVALGRKRAVFPDDMPTLSALP 1097
>gi|154146223 splicing factor, arginine/serine-rich 130 [Homo
sapiens]
Length = 805
Score = 52.0 bits (123), Expect = 2e-06
Identities = 73/358 (20%), Positives = 141/358 (39%), Gaps = 31/358 (8%)
Query: 127 ALQKEEEMEGDYQETWKATGSRSYSPDHRQKKHRKLSELERPHKVSHGHERRDERKRCHR 186
+L + E +GD K T + + S +K+H++ + R S R
Sbjct: 467 SLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSS 526
Query: 187 MSPTYSSDPESSDYGHVQSPPSCTSPHQMYVDHYRSLEEDQEPIVSHQKPGKGHSNAFQD 246
S T SS SS G ++ +SP + H RS + P + K + S ++
Sbjct: 527 TSSTVSSSSYSSSSGSSRTSSRSSSPKRKK-RHSRS----RSPTI---KARRSRSRSYSR 578
Query: 247 RLGASQER------HLGEPHGKGVVSQNKEHKSSHKDKRPVDAKS-DEKASVVSREKSHK 299
R+ R + + + + ++S +++R ++S D + + SR +S
Sbjct: 579 RIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRD 638
Query: 300 ALSKEENRRPPSGDNAREKPPSSGVKKEKDREGSSLKKKCLPPSEAASDNHLKKPKHRDP 359
++ R SG++ + K + +++K+R S K + E + +K K +
Sbjct: 639 RRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKRE 698
Query: 360 EK-----AKLDKSKQGLDSFDTGKGAGDLLPKVKEKGSNNLKTPEGKVKTNLDRKSLGSL 414
EK ++ D+ K+ +S T +G + K+ S + K T D K
Sbjct: 699 EKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQ----DSKKSTTKDSKKHSG- 753
Query: 415 PKVEETDMEDEFEQPTMSFESYLSYDQPRKKKKKIVKTSATALGDKGLKKNDSKSTGK 472
++ E P S E +P+ + + V+ S + G K +K+ SKS +
Sbjct: 754 ---SDSSGRSSSESPGSSKEK--KAKKPKHSRSRSVEKSQRS-GKKASRKHKSKSRSR 805
>gi|154146193 splicing factor, arginine/serine-rich 130 [Homo
sapiens]
Length = 805
Score = 52.0 bits (123), Expect = 2e-06
Identities = 73/358 (20%), Positives = 141/358 (39%), Gaps = 31/358 (8%)
Query: 127 ALQKEEEMEGDYQETWKATGSRSYSPDHRQKKHRKLSELERPHKVSHGHERRDERKRCHR 186
+L + E +GD K T + + S +K+H++ + R S R
Sbjct: 467 SLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSS 526
Query: 187 MSPTYSSDPESSDYGHVQSPPSCTSPHQMYVDHYRSLEEDQEPIVSHQKPGKGHSNAFQD 246
S T SS SS G ++ +SP + H RS + P + K + S ++
Sbjct: 527 TSSTVSSSSYSSSSGSSRTSSRSSSPKRKK-RHSRS----RSPTI---KARRSRSRSYSR 578
Query: 247 RLGASQER------HLGEPHGKGVVSQNKEHKSSHKDKRPVDAKS-DEKASVVSREKSHK 299
R+ R + + + + ++S +++R ++S D + + SR +S
Sbjct: 579 RIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRD 638
Query: 300 ALSKEENRRPPSGDNAREKPPSSGVKKEKDREGSSLKKKCLPPSEAASDNHLKKPKHRDP 359
++ R SG++ + K + +++K+R S K + E + +K K +
Sbjct: 639 RRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKRE 698
Query: 360 EK-----AKLDKSKQGLDSFDTGKGAGDLLPKVKEKGSNNLKTPEGKVKTNLDRKSLGSL 414
EK ++ D+ K+ +S T +G + K+ S + K T D K
Sbjct: 699 EKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQ----DSKKSTTKDSKKHSG- 753
Query: 415 PKVEETDMEDEFEQPTMSFESYLSYDQPRKKKKKIVKTSATALGDKGLKKNDSKSTGK 472
++ E P S E +P+ + + V+ S + G K +K+ SKS +
Sbjct: 754 ---SDSSGRSSSESPGSSKEK--KAKKPKHSRSRSVEKSQRS-GKKASRKHKSKSRSR 805
>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
containing B [Homo sapiens]
Length = 546
Score = 51.6 bits (122), Expect = 3e-06
Identities = 75/360 (20%), Positives = 135/360 (37%), Gaps = 56/360 (15%)
Query: 102 VPVERNAEPDEQDFEKSNSRKRPRDALQKEEEMEGDYQETWKATGSRSYSPDHRQKKHRK 161
VPV++N D+Q K+ RK +D + EE++ + + RS SP ++ R
Sbjct: 223 VPVQKNI--DQQI--KTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRS 278
Query: 162 LSELERPHKVSHGH-------ERRDERKRCHRMSPTYSSDPESS---DYGHVQSPPSCTS 211
S H+ HG ER ER+R R + + S D G
Sbjct: 279 RSH----HREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRG---------- 324
Query: 212 PHQMYVDHYRSLEEDQEPIVSHQKPGKGHSNAFQDRLGASQERHLGEPHGKGVVSQNKEH 271
++ RS ++ S + KG DR +ER G+ +
Sbjct: 325 -----LERRRSRSRERHRSRSRSRDRKG------DRRDRDREREKENERGRRRDRDYDKE 373
Query: 272 KSSHKDK---RPVDAKSDEKASVVSREKSHKALSKEENRRPPSGDNAREKPPSSGVKKEK 328
+ + ++K R + ++++ EK HK + R D+ +EK S +E+
Sbjct: 374 RGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRER 433
Query: 329 DREGSSLKKKCLPPSEAASDNHLKKPKHRDPEKAKLDK-SKQGLDSFDTGKGAGDLLPKV 387
S + S + S K KH++ K K +K S+ G +G D + K
Sbjct: 434 KHRSRSRSRNAGKRSRSRSKE--KSSKHKNESKEKSNKRSRSG------SQGRTDSVEKS 485
Query: 388 KEKGSNNLKTPEGKVKTNLDRKSLGSLPKVEETDMEDEFEQPTMSFESYLSYDQPRKKKK 447
K++ + K K + +R K + +D +D+ ++ + + K+ K
Sbjct: 486 KKREHSPSKEKSRKRSRSKERSH-----KRDHSDSKDQSDKHDRRRSQSIEQESQEKQHK 540
>gi|239749424 PREDICTED: hypothetical protein XP_002347041 [Homo
sapiens]
Length = 287
Score = 51.2 bits (121), Expect = 4e-06
Identities = 35/123 (28%), Positives = 57/123 (46%), Gaps = 13/123 (10%)
Query: 53 LKYLKKLSTLPITVDILAETGVGKTVNSLRKH---EHVGSFARDLVAQWKKLVPVERNAE 109
L LK+L +P+T+++L T +G +VN++RK E V S A+ L+ WKKL+
Sbjct: 11 LDLLKELKNIPMTLELLQSTRIGMSVNAIRKQSTDEEVTSLAKSLIKSWKKLL------- 63
Query: 110 PDEQDFEKSNSRKRPRDALQKEEEMEGDYQETWKATGSRSYSPDHRQKKHRKLSELERPH 169
D EK K+ A+ + E + T ++G+ S D + +S R
Sbjct: 64 -DGPSTEKDLDEKKKEPAITSQNSPEAREEST--SSGNVSNRKDETNARDTYVSSFPRAP 120
Query: 170 KVS 172
S
Sbjct: 121 STS 123
>gi|5803191 transcription elongation factor A 1 isoform 1 [Homo
sapiens]
Length = 301
Score = 51.2 bits (121), Expect = 4e-06
Identities = 35/123 (28%), Positives = 57/123 (46%), Gaps = 13/123 (10%)
Query: 53 LKYLKKLSTLPITVDILAETGVGKTVNSLRKH---EHVGSFARDLVAQWKKLVPVERNAE 109
L LK+L +P+T+++L T +G +VN++RK E V S A+ L+ WKKL+
Sbjct: 25 LDLLKELKNIPMTLELLQSTRIGMSVNAIRKQSTDEEVTSLAKSLIKSWKKLL------- 77
Query: 110 PDEQDFEKSNSRKRPRDALQKEEEMEGDYQETWKATGSRSYSPDHRQKKHRKLSELERPH 169
D EK K+ A+ + E + T ++G+ S D + +S R
Sbjct: 78 -DGPSTEKDLDEKKKEPAITSQNSPEAREEST--SSGNVSNRKDETNARDTYVSSFPRAP 134
Query: 170 KVS 172
S
Sbjct: 135 STS 137
>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
Length = 494
Score = 50.1 bits (118), Expect = 8e-06
Identities = 62/280 (22%), Positives = 106/280 (37%), Gaps = 24/280 (8%)
Query: 103 PVERNAEPDEQDFEKSNSRKRPRDALQKEEEMEGDYQETWKATGSRSYSPDHRQKKHRKL 162
P R + S SR R R + +K G + + + SRS S + K R
Sbjct: 177 PGSRRRRSYSRSRSHSRSRSRSRHS-RKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSR 235
Query: 163 SELERPHKV--SHGHERRDERKRCHRMSPTYSSDPESSDYGHVQSPPSCTSPHQMYVDHY 220
S+ K S + R R H + S + ++ +Q+ + P +
Sbjct: 236 SQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEE-KIQNNDNVGKPKSRSPSRH 294
Query: 221 RSLEED----QEPIVSHQKPGKGHSNAFQDRLGASQERHLGEPHGKGVVSQNKEHKSSHK 276
+S + QE V +K G Q++ S + KG +S K
Sbjct: 295 KSKSKSRSRSQERRVEEEKRGSVSRGRSQEK---SLRQSRSRSRSKGGSRSRSRSRSKSK 351
Query: 277 DKRPVDAKSDEKASVVSR-----EKSHKALSKEEN-------RRPPSGDNAREKPPSSGV 324
DKR +S E++ SR E+S K SK ++ ++ D ++ + PS V
Sbjct: 352 DKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSV 411
Query: 325 KKEKDR-EGSSLKKKCLPPSEAASDNHLKKPKHRDPEKAK 363
KE++ + S +++ SE A N + + R K+K
Sbjct: 412 SKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSK 451
Score = 44.3 bits (103), Expect = 5e-04
Identities = 36/135 (26%), Positives = 64/135 (47%), Gaps = 12/135 (8%)
Query: 235 KPGKGHSNAFQDRLGASQERHLGEPHGKGVVSQNKEHKSSHKDKRPVDAKSDEKASVVSR 294
KPG ++ S+ R H + S++ KSSH R ++S ++ SR
Sbjct: 176 KPGSRRRRSYSRSRSHSRSRSRSR-HSRKSRSRSGSSKSSHSKSRS-RSRSGSRSRSKSR 233
Query: 295 EKSH-KALSKEENRRPPSGDNAREKPPSSGVKKEKDREGSSLKKKCLPPSEAASDNHLKK 353
+S ++ SK+E R PS + +R + S+G + K ++ + K +++++ K
Sbjct: 234 SRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEK--------IQNNDNVGK 285
Query: 354 PKHRDPEKAKLDKSK 368
PK R P + K KSK
Sbjct: 286 PKSRSPSRHK-SKSK 299
Score = 36.6 bits (83), Expect = 0.094
Identities = 45/195 (23%), Positives = 75/195 (38%), Gaps = 18/195 (9%)
Query: 282 DAKSDEKASVVSREKSHKALSKEENRRPPSGDNAREKPPSSGVKKEKDREGSSLKKKCLP 341
D + SR +SH S + S + + R GS + K
Sbjct: 175 DKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRS 234
Query: 342 PSEAASDNHLKKPKHRDPEKAKLDKSKQGLDSFDTGKGAGDLLPKVKEKGSNNLKTPEGK 401
S++ S + KK K R P K K +S+ S GK + +EK NN + K
Sbjct: 235 RSQSRSRS--KKEKSRSPSKEK-SRSR----SHSAGKSRSKSKDQAEEKIQNNDNVGKPK 287
Query: 402 VKTNLDRKSLG-SLPKVEETDMEDEFEQPTMSFESYLSYDQPRKKKKKIVKTSATALGDK 460
++ KS S + +E +E+E S + R ++K + + S + K
Sbjct: 288 SRSPSRHKSKSKSRSRSQERRVEEEKRG---------SVSRGRSQEKSL-RQSRSRSRSK 337
Query: 461 GLKKNDSKSTGKNLD 475
G ++ S+S K+ D
Sbjct: 338 GGSRSRSRSRSKSKD 352
Score = 30.8 bits (68), Expect = 5.2
Identities = 51/261 (19%), Positives = 85/261 (32%), Gaps = 25/261 (9%)
Query: 117 KSNSRKRPRDALQKEEEMEGDYQETWKATGSRSYSPDHRQKKHRKLSELERPHKVSHGHE 176
+S SR R + + E + A SRS S D ++K + + +P S
Sbjct: 235 RSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRH 294
Query: 177 RRDERKRCHRMSPTYSSDPESSDYGHVQSPPSCTSPHQMYVDHYRSLEEDQEPIVSHQKP 236
+ + R S + E G V S + RS + S K
Sbjct: 295 KSKSKSR----SRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKS 350
Query: 237 G---KGHSNAFQDRLGASQERHLGEPHGK-GVVSQNKEHKSSHKDKRPVD-AKSDEKASV 291
KG + ++ S+ R E K G +K S K K D ++S +
Sbjct: 351 KDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRS 410
Query: 292 VSREKSHK----------------ALSKEENRRPPSGDNAREKPPSSGVKKEKDREGSSL 335
VS+E+ H ++E R S ++ PS + K +
Sbjct: 411 VSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSKSASKTRS 470
Query: 336 KKKCLPPSEAASDNHLKKPKH 356
+ K S + S + + H
Sbjct: 471 RSKSRSRSASRSPSRSRSRSH 491
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 50.1 bits (118), Expect = 8e-06
Identities = 86/398 (21%), Positives = 140/398 (35%), Gaps = 66/398 (16%)
Query: 99 KKLVPVERNAEPDEQDFEKSNSRKR----PRDALQKEEEMEGDYQETWKATGSRSYSPDH 154
+K +E+N + D+ EK S++R RD ++KE E ++ R P
Sbjct: 698 EKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTD 757
Query: 155 RQKKHRKLSELERPHKVSHGHERRDERKRCHRMSPTYSSDPESSDYGHVQSPPSCTSPHQ 214
+ + L G +E H + + + H++ S P +
Sbjct: 758 KDSEFTSL-----------GMSAIEESIGLHLVEKEIDIEKQEK---HIKE--SKEKPEK 801
Query: 215 MYVDHYRSLEEDQEPIVSHQKPGKGHSNAFQDRLGASQ------------ERHLGEPHGK 262
+ +E+ + +K K + +D+L S+ H + H +
Sbjct: 802 RSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKE 861
Query: 263 GVVSQNKEHKSSHKDKRPVDAKSDEKASVVSREKS-HKALSKEEN---RRPPSGDNAREK 318
G S+N D+ K D K EK H A SKE++ ++ DN+
Sbjct: 862 GEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYS 921
Query: 319 PPSSGVKKEKDREGSSLKKKCLPPSEAASDNHLKKPKHRDPEKAKLDKSKQGLDS----- 373
G KEKDRE KK K RD E + SK +
Sbjct: 922 KSEKGKNKEKDRELD------------------KKEKSRDKESINITNSKHIQEEKKSSI 963
Query: 374 FDTGKGAGDLLPKVKEKGSNN-LKTPEGKVKTNLDRKSLGSLPKVEETDMEDEFEQPTMS 432
D K + +KEK + LKTP+GK K D+ + + +E D + Q
Sbjct: 964 VDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDK----DIDRYKERDKHKDKIQINSL 1019
Query: 433 FESYLSYDQPRKKKKKIVKTSATALGDKGLKKNDSKST 470
+ D+P+ K K T +K L +D T
Sbjct: 1020 LKLKSEADKPKPKSSPASKD--TRPKEKRLVNDDLMQT 1055
Score = 33.1 bits (74), Expect = 1.0
Identities = 63/273 (23%), Positives = 112/273 (41%), Gaps = 41/273 (15%)
Query: 248 LGASQERHLGEPHGKGVVSQNKEHKSSHKDKRPVDAKSDE----KASVVS---REKS--- 297
L Q L + H K +S S D D E +SV S +EKS
Sbjct: 527 LSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQ 586
Query: 298 ---HKALSKEENRRPPSGDNAREKPPSSGVKKEKDREGSSLKKKCLPPSEAASDNHLKKP 354
H ++ N + D++ S K+ D+EG +LKK K
Sbjct: 587 KDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKK--------------HKL 632
Query: 355 KHRDPEKAKLDKSKQG-LDSFDTGKGAGDLLPKVKEK----GSNNLKTPEGK-VKTNLDR 408
KH++ EK K K +G + + T A +L V+ N K+ E + + N++
Sbjct: 633 KHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEH 692
Query: 409 KSLGSLPKVEETDMEDEFEQPTMSFESYLSYDQPRKKKK-KIVKTSATALGDKGLKKNDS 467
+SL +L K ++ +E + + E ++S ++ K+++ KI K S + ++ +K D
Sbjct: 693 ESL-TLEK--KSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIK--DL 747
Query: 468 KSTGKNL--DSVQKLPKVNKTKSEKPAGADLAK 498
K +N+ D + + + E+ G L +
Sbjct: 748 KEERENIPTDKDSEFTSLGMSAIEESIGLHLVE 780
Score = 32.7 bits (73), Expect = 1.4
Identities = 33/137 (24%), Positives = 56/137 (40%), Gaps = 8/137 (5%)
Query: 277 DKRPVDAKSDEKASVVSREKSHKALSKEENRRPPSGDNAREKP-----PSSGVKKEKDRE 331
D R + K K + EK+H +E+ P S + ++KP S+ E+ +
Sbjct: 353 DDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQ 412
Query: 332 GSSLKKKC-LPPSEAASDNHLKKPKHRDPEKAKLDKSKQGLDSFDTGKGAGDLLPKVKEK 390
+ C + P + SD KK E + K K+ L + + K +L K +++
Sbjct: 413 NKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQEL--KQEKE 470
Query: 391 GSNNLKTPEGKVKTNLD 407
G N + V T LD
Sbjct: 471 GKENTRITNLTVNTGLD 487
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 50.1 bits (118), Expect = 8e-06
Identities = 86/398 (21%), Positives = 140/398 (35%), Gaps = 66/398 (16%)
Query: 99 KKLVPVERNAEPDEQDFEKSNSRKR----PRDALQKEEEMEGDYQETWKATGSRSYSPDH 154
+K +E+N + D+ EK S++R RD ++KE E ++ R P
Sbjct: 721 EKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTD 780
Query: 155 RQKKHRKLSELERPHKVSHGHERRDERKRCHRMSPTYSSDPESSDYGHVQSPPSCTSPHQ 214
+ + L G +E H + + + H++ S P +
Sbjct: 781 KDSEFTSL-----------GMSAIEESIGLHLVEKEIDIEKQEK---HIKE--SKEKPEK 824
Query: 215 MYVDHYRSLEEDQEPIVSHQKPGKGHSNAFQDRLGASQ------------ERHLGEPHGK 262
+ +E+ + +K K + +D+L S+ H + H +
Sbjct: 825 RSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKE 884
Query: 263 GVVSQNKEHKSSHKDKRPVDAKSDEKASVVSREKS-HKALSKEEN---RRPPSGDNAREK 318
G S+N D+ K D K EK H A SKE++ ++ DN+
Sbjct: 885 GEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYS 944
Query: 319 PPSSGVKKEKDREGSSLKKKCLPPSEAASDNHLKKPKHRDPEKAKLDKSKQGLDS----- 373
G KEKDRE KK K RD E + SK +
Sbjct: 945 KSEKGKNKEKDRELD------------------KKEKSRDKESINITNSKHIQEEKKSSI 986
Query: 374 FDTGKGAGDLLPKVKEKGSNN-LKTPEGKVKTNLDRKSLGSLPKVEETDMEDEFEQPTMS 432
D K + +KEK + LKTP+GK K D+ + + +E D + Q
Sbjct: 987 VDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDK----DIDRYKERDKHKDKIQINSL 1042
Query: 433 FESYLSYDQPRKKKKKIVKTSATALGDKGLKKNDSKST 470
+ D+P+ K K T +K L +D T
Sbjct: 1043 LKLKSEADKPKPKSSPASKD--TRPKEKRLVNDDLMQT 1078
Score = 33.1 bits (74), Expect = 1.0
Identities = 63/273 (23%), Positives = 112/273 (41%), Gaps = 41/273 (15%)
Query: 248 LGASQERHLGEPHGKGVVSQNKEHKSSHKDKRPVDAKSDE----KASVVS---REKS--- 297
L Q L + H K +S S D D E +SV S +EKS
Sbjct: 550 LSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQ 609
Query: 298 ---HKALSKEENRRPPSGDNAREKPPSSGVKKEKDREGSSLKKKCLPPSEAASDNHLKKP 354
H ++ N + D++ S K+ D+EG +LKK K
Sbjct: 610 KDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKK--------------HKL 655
Query: 355 KHRDPEKAKLDKSKQG-LDSFDTGKGAGDLLPKVKEK----GSNNLKTPEGK-VKTNLDR 408
KH++ EK K K +G + + T A +L V+ N K+ E + + N++
Sbjct: 656 KHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEH 715
Query: 409 KSLGSLPKVEETDMEDEFEQPTMSFESYLSYDQPRKKKK-KIVKTSATALGDKGLKKNDS 467
+SL +L K ++ +E + + E ++S ++ K+++ KI K S + ++ +K D
Sbjct: 716 ESL-TLEK--KSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIK--DL 770
Query: 468 KSTGKNL--DSVQKLPKVNKTKSEKPAGADLAK 498
K +N+ D + + + E+ G L +
Sbjct: 771 KEERENIPTDKDSEFTSLGMSAIEESIGLHLVE 803
Score = 32.7 bits (73), Expect = 1.4
Identities = 33/137 (24%), Positives = 56/137 (40%), Gaps = 8/137 (5%)
Query: 277 DKRPVDAKSDEKASVVSREKSHKALSKEENRRPPSGDNAREKP-----PSSGVKKEKDRE 331
D R + K K + EK+H +E+ P S + ++KP S+ E+ +
Sbjct: 376 DDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQ 435
Query: 332 GSSLKKKC-LPPSEAASDNHLKKPKHRDPEKAKLDKSKQGLDSFDTGKGAGDLLPKVKEK 390
+ C + P + SD KK E + K K+ L + + K +L K +++
Sbjct: 436 NKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQEL--KQEKE 493
Query: 391 GSNNLKTPEGKVKTNLD 407
G N + V T LD
Sbjct: 494 GKENTRITNLTVNTGLD 510
>gi|213385278 TNF receptor-associated factor 3 interacting protein 1
isoform 2 [Homo sapiens]
Length = 625
Score = 50.1 bits (118), Expect = 8e-06
Identities = 52/257 (20%), Positives = 103/257 (40%), Gaps = 17/257 (6%)
Query: 257 GEPHGKGVV---SQNKEHKSSHKDKRPVDAKSDEKASVVSREKSHKALSKE-----ENRR 308
GE G+ + SQ ++K+ +++ V ++++ +E+S K+ E+R+
Sbjct: 134 GEVKGRASLTSRSQELDNKNVREEESRVHKNTEDRGDAEIKERSTSRDRKQKEELKEDRK 193
Query: 309 PPSGDNAREKPPSSGVKKEKDREGSSLKKKCLPPSEAASDNHLKKPKHRDPEKAKLDKSK 368
P D +EK +G + ++ E K + P +E D ++ K + ++
Sbjct: 194 PREKDKDKEKAKENGGNRHREGERERAKARARPDNERQKDRGNRERDRDSERKKETERKS 253
Query: 369 QGLDSFDTGKGAGDLLPKVKEKGSNNLKTPEGKVKTNLDRKSLGSLPKVEETDMEDEFEQ 428
+G + + + K K + + G+ +LDR+ K E D ++
Sbjct: 254 EGGKEKERLRDRDRERDRDKGKDRDRRRVKNGEHSWDLDRE------KNREHDKPEKKSA 307
Query: 429 PTMSFESYLSYDQPRKKKKKIVKTSATALGDKGLKKNDSKSTGKNLDSVQKLPKVNKTKS 488
+ LS D K K +T + K L SK KN SV+ +
Sbjct: 308 SSGEMSKKLS-DGTFKDSKAETETEISTRASKSLTTKTSKRRSKN--SVEGDSTSDAEGD 364
Query: 489 EKPAGADLAKLRKVPDV 505
PAG D +++ + P++
Sbjct: 365 AGPAGQDKSEVPETPEI 381
>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
Length = 1007
Score = 50.1 bits (118), Expect = 8e-06
Identities = 88/510 (17%), Positives = 203/510 (39%), Gaps = 65/510 (12%)
Query: 101 LVPVERNAEPDEQDFEKSNSRKRPRDALQKEEEMEGDYQETWKATGSRSYSPDHRQKKHR 160
+ E + ++ + E +NS K + + E + + + + H++ KH
Sbjct: 1 MAAAETQSLREQPEMEDANSEKSINEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHS 60
Query: 161 KLSELERPHKVSHGHERRDERKRC-----HRMSPTYSSDPE---------------SSDY 200
+ ++ HK H H++ ++ MSP + + ++
Sbjct: 61 SEEDKDKKHKHKHKHKKHKRKEIIDASDKEGMSPAKRTKLDDLALLEDLEKQRALIKAEL 120
Query: 201 GHVQSPPSCTSPHQMYVDHYRSLEEDQEPIVSHQKPGKGHSNAFQDRLGASQERHLGEPH 260
+ S + + Y S E++ I H+K G+ ++ + +S + L
Sbjct: 121 DNELMEGKVQSGMGLILQGYESGSEEEGEI--HEKARNGNRSSTR---SSSTKGKLELVD 175
Query: 261 GKGVVSQNKEHKSSHKDKRPVDAKSDEKASVVSREKSHKALSKEE------NRRPPSGDN 314
K + + +S + + D K + + +EK+ ++ SKE ++R S D
Sbjct: 176 NKITTKKRSKSRSKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQ 235
Query: 315 AREKPPSSGVKKEKDREGSSLKKKCLPPSEAASDNHLK---KPKHRDPEKAKLDKSKQGL 371
AR+ + ++ +++ G + + +D+ +K K K +D +K+ + +
Sbjct: 236 ARKSKSPTLRRRSQEKIGK---------ARSPTDDKVKIEDKSKSKDRKKSPIINESRSR 286
Query: 372 DSFDTGKGAGDLLPKVKEKGSNNLKTPEGKVKTNLDRKSLGSLPKVEETDMEDE--FEQP 429
D + DL K K++ S + + + +T+ ++K + S K + E+ +P
Sbjct: 287 DRGKKSRSPVDLRGKSKDRRSRSKERKSKRSETDKEKKPIKSPSKDASSGKENRSPSRRP 346
Query: 430 TMSFESYLSYDQPRKKKKKIVKTSATALGDKGLKKNDS---------KSTGKNLDSVQKL 480
S + +PR K + ++ + L D+ K++ S ++ ++L+ ++
Sbjct: 347 GRSPKRRSLSPKPRDKSR---RSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRRE 403
Query: 481 PKVNKTKSEKPAGAD--LAKLRKVPDVLPVLPDLPL-PAIQANYRPLPSLELISSFQPKR 537
P+ + S + D L++ + D P+ P ++ R L S P+R
Sbjct: 404 PERRRLSSPRTRPRDDILSRRERSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRSPRR 463
Query: 538 KAFSSPQEEEEAGFTGRRMNSKMQVYSGSK 567
++ SP+ + GRR S+++ S S+
Sbjct: 464 RS-RSPRRRDR----GRRSRSRLRRRSRSR 488
>gi|41350335 transcription elongation factor A (SII), 3 [Homo
sapiens]
Length = 348
Score = 49.7 bits (117), Expect = 1e-05
Identities = 44/173 (25%), Positives = 75/173 (43%), Gaps = 19/173 (10%)
Query: 30 ESALQVVEKLQARLAANPDPKKLLKYLKKLSTLPITVDILAETGVGKTVNSLRKH---EH 86
E L++ +KL+ ++ A + + L LKKL + +++ +L T +G VN +RKH +
Sbjct: 5 EELLRIAKKLE-KMVARKNTEGALDLLKKLHSCQMSIQLLQTTRIGVAVNGVRKHCSDKE 63
Query: 87 VGSFARDLVAQWKKLVPVERNAEPDEQDFEKSNSRKRPRDALQKEEEMEGDYQETWKATG 146
V S A+ L+ WK+L+ P EK R++ A +KE+ +E WK
Sbjct: 64 VVSLAKVLIKNWKRLLD-----SPGPPKGEKGEEREK---AKKKEKGLE---CSDWKPEA 112
Query: 147 SRSYSPDHRQKKHRKLSELERPHKVSHGHER----RDERKRCHRMSPTYSSDP 195
S R+ + ++ S +R R + SP S P
Sbjct: 113 GLSPPRKKREDPKTRRDSVDSKSSASSSPKRPSVERSNSSKSKAESPKTPSSP 165
>gi|27477095 nuclear receptor binding SET domain protein 1 isoform a
[Homo sapiens]
Length = 2427
Score = 49.3 bits (116), Expect = 1e-05
Identities = 80/362 (22%), Positives = 142/362 (39%), Gaps = 50/362 (13%)
Query: 234 QKPGKGHSNAFQDRLGASQERHLGEPHGKGVVSQNKEHKSSHKDKRPVDAKSDEKASVVS 293
+ P K L + H + H V Q+ K S K + K E SV++
Sbjct: 814 EDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELDSVMN 873
Query: 294 REKSH-KALSKEENRRPPSGDNAREKPPSSGVKKEKDREGSSLKKKCLPPSEAASDNHLK 352
E +++ ++ N R P + + K++E S + L PS+ + +
Sbjct: 874 SENDELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGRDE 933
Query: 353 KPKHRDPEKAKLDKSKQGLDSFDTGKGAGDLLPKVKEKGSNNLKTPEGKVKTNLDRKSL- 411
P+HR P + L++ + D AG L V +K S ++ G ++ SL
Sbjct: 934 FPEHRTPSASILEEPLTEQNHADCLDSAGPRL-NVCDKSSASI----GDMEKEPGIPSLT 988
Query: 412 --GSLPKVEETDMEDEFEQPTMSFESYL-SYDQ---PRKKKKKIV----KTSATALGDKG 461
LP+ + +P+ Y YDQ P+KK+KK+ K S+ +
Sbjct: 989 PQAELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEEESL 1048
Query: 462 LKKNDSKSTGKNLD-----SVQKLPKVNKTK--------SEKPAGADLAKLRKVPDVLPV 508
L + S + K +D S ++ P V + + ++ G A+L ++ +PV
Sbjct: 1049 LARGRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSELGGGHAELPQLTLSVPV 1108
Query: 509 LPDL-PLPAIQA---------NY----------RPLPSLELISSFQPKRKAFSSPQEEEE 548
P++ P PA+++ NY + L S +L F PK+ ++ E
Sbjct: 1109 APEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCYE 1168
Query: 549 AG 550
AG
Sbjct: 1169 AG 1170
>gi|19923586 nuclear receptor binding SET domain protein 1 isoform b
[Homo sapiens]
Length = 2696
Score = 49.3 bits (116), Expect = 1e-05
Identities = 80/362 (22%), Positives = 142/362 (39%), Gaps = 50/362 (13%)
Query: 234 QKPGKGHSNAFQDRLGASQERHLGEPHGKGVVSQNKEHKSSHKDKRPVDAKSDEKASVVS 293
+ P K L + H + H V Q+ K S K + K E SV++
Sbjct: 1083 EDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELDSVMN 1142
Query: 294 REKSH-KALSKEENRRPPSGDNAREKPPSSGVKKEKDREGSSLKKKCLPPSEAASDNHLK 352
E +++ ++ N R P + + K++E S + L PS+ + +
Sbjct: 1143 SENDELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGRDE 1202
Query: 353 KPKHRDPEKAKLDKSKQGLDSFDTGKGAGDLLPKVKEKGSNNLKTPEGKVKTNLDRKSL- 411
P+HR P + L++ + D AG L V +K S ++ G ++ SL
Sbjct: 1203 FPEHRTPSASILEEPLTEQNHADCLDSAGPRL-NVCDKSSASI----GDMEKEPGIPSLT 1257
Query: 412 --GSLPKVEETDMEDEFEQPTMSFESYL-SYDQ---PRKKKKKIV----KTSATALGDKG 461
LP+ + +P+ Y YDQ P+KK+KK+ K S+ +
Sbjct: 1258 PQAELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEEESL 1317
Query: 462 LKKNDSKSTGKNLD-----SVQKLPKVNKTK--------SEKPAGADLAKLRKVPDVLPV 508
L + S + K +D S ++ P V + + ++ G A+L ++ +PV
Sbjct: 1318 LARGRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSELGGGHAELPQLTLSVPV 1377
Query: 509 LPDL-PLPAIQA---------NY----------RPLPSLELISSFQPKRKAFSSPQEEEE 548
P++ P PA+++ NY + L S +L F PK+ ++ E
Sbjct: 1378 APEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCYE 1437
Query: 549 AG 550
AG
Sbjct: 1438 AG 1439
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 49.3 bits (116), Expect = 1e-05
Identities = 85/424 (20%), Positives = 154/424 (36%), Gaps = 43/424 (10%)
Query: 104 VERNAEPDEQDFEKSNSRKRPRDALQKE--EEMEGDYQETWKATGSRSYSPDHRQKKHRK 161
+E+ +P+ + K + + + +++ +E++G QE K T ++ QK K
Sbjct: 190 IEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEV---QKTPSK 246
Query: 162 LSELERPHKVSHG-HERRDERKRCHRMSPTYSSDPESSDYGHVQSPPSCTSPHQMYVDHY 220
E E K + HE++D+ C M + PP T
Sbjct: 247 PKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPAS 306
Query: 221 RSLEEDQ-EPIVSHQKPGKGHSNAFQDRLGASQERHLG---EPHGKGVVSQNKE------ 270
+LEE + E + +K ++ + E+ E G S+ K+
Sbjct: 307 PALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIA 366
Query: 271 -HKSSHKDKRPVDAKSDEKASVVSREKSHKALSKEENRRPPSGDNAREKPPS-----SGV 324
++ KD++ D+K +K + V + K K KE++ P PS +
Sbjct: 367 AQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKT 426
Query: 325 KKEKDREGSSLKKKCLPPSEAASDNHLKKPKHRDPEKAKLDKSKQGLDSFDTGKGAGDLL 384
++ K+ G+ KK +P + K ++ K K K+ L + KG + +
Sbjct: 427 ERAKEEIGAVSIKKAVP---GKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKV 483
Query: 385 PKVKEKGSNNLKTPEGKVKTNLDRKSLGSLPKVEETDMEDEFEQPTMSFESYLSYDQPRK 444
P S K PE K + + PK + + E E+P Q +K
Sbjct: 484 P-----ASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKE-EKPE---------PQIKK 528
Query: 445 KKKKIVKTSATALGDKGLKKNDSKSTGKNLDSVQKLPK---VNKTKSEKPAGADLAKLRK 501
+ K + +K + S GK + V K K + KT KP + R+
Sbjct: 529 EAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHRERE 588
Query: 502 VPDV 505
P +
Sbjct: 589 PPSI 592
Score = 42.7 bits (99), Expect = 0.001
Identities = 64/263 (24%), Positives = 106/263 (40%), Gaps = 33/263 (12%)
Query: 272 KSSHKDKRPVDAKSDEKASVVSREKSHKALSKEENRRPPSGDNAREKPPSSGVKKEKDRE 331
K +HK+K K EK + + + K+E +P + A+E+ + +K +++
Sbjct: 161 KVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKE--KPETKTLAKEQKKAKTAEKSEEKT 218
Query: 332 GSSLK--KKCLPPSEAASDNHLK----KPKHR-DPEKAKLDKSKQG---------LDSF- 374
+K K+ AA ++ KPK + D EKA + K +Q +D F
Sbjct: 219 KKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFV 278
Query: 375 --DTGKGAGDLLPKVKEKGSNNLKTP--------EGKVKTNLDRKSLGSLPKVEETDMED 424
D G +P + TP EG+ K ++K K E+ D++
Sbjct: 279 HGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGE-KKKAEKKVTSETKKKEKEDIKK 337
Query: 425 EFEQPTMSFESYLSYDQPRKKKKKIVKTSATALGDKGLKKNDSKSTGKNLDSVQKLPKVN 484
+ E+ T + + K+ VK +A A K KK DSK T K + Q PK
Sbjct: 338 KSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQ--PK-G 394
Query: 485 KTKSEKPAGADLAKLRKVPDVLP 507
K + +K + AK K +P
Sbjct: 395 KKQEKKEKHVEPAKSPKKEHSVP 417
>gi|52426743 cisplatin resistance-associated overexpressed protein
[Homo sapiens]
Length = 432
Score = 49.3 bits (116), Expect = 1e-05
Identities = 52/230 (22%), Positives = 88/230 (38%), Gaps = 34/230 (14%)
Query: 105 ERNAEPDEQDFEKSNSRKRPRDALQKEEEMEGDYQETWKATGSRSYSPDHRQKKHRKLSE 164
+R EPD E+ K+ R+ +KE E E + +E R + R+K+ + E
Sbjct: 236 KRTEEPDRD--ERLKKEKQEREEREKEREREREERER-----KRRREEEEREKERARDRE 288
Query: 165 LERPHKVSHGHERRDERKRCHRMSPTYSSDPESSDYGHVQSPPSCTSPHQMYVDHYRSLE 224
+ + H R +RC R S D+ +S + RS
Sbjct: 289 RRKRSRSRSRHSSRTSDRRCSR----------SRDHKRSRSR-----------ERRRSRS 327
Query: 225 EDQEPIVSHQKPGKGHSNAFQDRLGASQERHLGEPHGKGVVSQNKEHKSSHKDKRPVDAK 284
D+ SH + + H + +DR + H + ++ KS K+KR D
Sbjct: 328 RDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSD-- 385
Query: 285 SDEKASVVSREKSHKALSKEENRRPPSGDNARE-KPPSSGVKKEKDREGS 333
D+K+SV + S + S++ N D E S +K E D + +
Sbjct: 386 -DKKSSV--KSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQSN 432
Score = 33.1 bits (74), Expect = 1.0
Identities = 31/128 (24%), Positives = 53/128 (41%), Gaps = 11/128 (8%)
Query: 266 SQNKEHKSSHKDKRPVDAKSDEKASVV--SREKSHKALSKEENRRPPSGDNAREKPPSSG 323
S++++HK S +R D + S E+ H++ S+ + RR S D K S
Sbjct: 309 SRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSR-DRRRSKSRDRKSYKHRSKS 367
Query: 324 VKKEKDREGSSLKKKCLPPSEAASDNHLKKPKHRDPEKAKLDKSKQGLDSFDTGKGAGDL 383
+E+DR+ +K+ SD+ K EK D + + +S DT
Sbjct: 368 RDREQDRKSKEKEKR-------GSDDKKSSVKSGSREKQSEDTNTESKES-DTKNEVNGT 419
Query: 384 LPKVKEKG 391
+K +G
Sbjct: 420 SEDIKSEG 427
>gi|19923485 cisplatin resistance-associated overexpressed protein
[Homo sapiens]
Length = 432
Score = 49.3 bits (116), Expect = 1e-05
Identities = 52/230 (22%), Positives = 88/230 (38%), Gaps = 34/230 (14%)
Query: 105 ERNAEPDEQDFEKSNSRKRPRDALQKEEEMEGDYQETWKATGSRSYSPDHRQKKHRKLSE 164
+R EPD E+ K+ R+ +KE E E + +E R + R+K+ + E
Sbjct: 236 KRTEEPDRD--ERLKKEKQEREEREKEREREREERER-----KRRREEEEREKERARDRE 288
Query: 165 LERPHKVSHGHERRDERKRCHRMSPTYSSDPESSDYGHVQSPPSCTSPHQMYVDHYRSLE 224
+ + H R +RC R S D+ +S + RS
Sbjct: 289 RRKRSRSRSRHSSRTSDRRCSR----------SRDHKRSRSR-----------ERRRSRS 327
Query: 225 EDQEPIVSHQKPGKGHSNAFQDRLGASQERHLGEPHGKGVVSQNKEHKSSHKDKRPVDAK 284
D+ SH + + H + +DR + H + ++ KS K+KR D
Sbjct: 328 RDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSD-- 385
Query: 285 SDEKASVVSREKSHKALSKEENRRPPSGDNARE-KPPSSGVKKEKDREGS 333
D+K+SV + S + S++ N D E S +K E D + +
Sbjct: 386 -DKKSSV--KSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQSN 432
Score = 33.1 bits (74), Expect = 1.0
Identities = 31/128 (24%), Positives = 53/128 (41%), Gaps = 11/128 (8%)
Query: 266 SQNKEHKSSHKDKRPVDAKSDEKASVV--SREKSHKALSKEENRRPPSGDNAREKPPSSG 323
S++++HK S +R D + S E+ H++ S+ + RR S D K S
Sbjct: 309 SRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSR-DRRRSKSRDRKSYKHRSKS 367
Query: 324 VKKEKDREGSSLKKKCLPPSEAASDNHLKKPKHRDPEKAKLDKSKQGLDSFDTGKGAGDL 383
+E+DR+ +K+ SD+ K EK D + + +S DT
Sbjct: 368 RDREQDRKSKEKEKR-------GSDDKKSSVKSGSREKQSEDTNTESKES-DTKNEVNGT 419
Query: 384 LPKVKEKG 391
+K +G
Sbjct: 420 SEDIKSEG 427
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.127 0.364
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,121,017
Number of Sequences: 37866
Number of extensions: 1851845
Number of successful extensions: 9357
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 517
Number of HSP's that attempted gapping in prelim test: 7409
Number of HSP's gapped (non-prelim): 1902
length of query: 798
length of database: 18,247,518
effective HSP length: 110
effective length of query: 688
effective length of database: 14,082,258
effective search space: 9688593504
effective search space used: 9688593504
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.