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Search of human proteins with 19882241
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19882241 immunoglobulin superfamily, DCC subclass, member 4
[Homo sapiens]
(1250 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19882241 immunoglobulin superfamily, DCC subclass, member 4 [... 2545 0.0
gi|83281200 protogenin [Homo sapiens] 668 0.0
gi|134244585 putative neuronal cell adhesion molecule [Homo sapi... 397 e-110
gi|157311649 neogenin homolog 1 [Homo sapiens] 271 4e-72
gi|110431348 deleted in colorectal carcinoma [Homo sapiens] 250 5e-66
gi|239741341 PREDICTED: similar to hCG1996527 [Homo sapiens] 247 6e-65
gi|169162264 PREDICTED: similar to hCG1996527 [Homo sapiens] 244 5e-64
gi|239747467 PREDICTED: similar to hCG1996527 [Homo sapiens] 244 5e-64
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 194 3e-49
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 189 1e-47
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 189 1e-47
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 187 5e-47
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 183 8e-46
gi|119220552 sidekick 1 [Homo sapiens] 183 1e-45
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 178 3e-44
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 176 1e-43
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 169 2e-41
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 169 2e-41
gi|28373122 contactin 4 isoform a precursor [Homo sapiens] 166 2e-40
gi|19743806 roundabout 1 isoform b [Homo sapiens] 165 2e-40
gi|4506569 roundabout 1 isoform a [Homo sapiens] 165 2e-40
gi|81158224 neuronal cell adhesion molecule isoform B precursor ... 165 3e-40
gi|224994173 roundabout 1 isoform d [Homo sapiens] 162 2e-39
gi|224994171 roundabout 1 isoform c [Homo sapiens] 162 2e-39
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 162 2e-39
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 162 2e-39
gi|81158226 neuronal cell adhesion molecule isoform A precursor ... 160 7e-39
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 159 1e-38
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 158 3e-38
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 157 6e-38
>gi|19882241 immunoglobulin superfamily, DCC subclass, member 4 [Homo
sapiens]
Length = 1250
Score = 2545 bits (6597), Expect = 0.0
Identities = 1250/1250 (100%), Positives = 1250/1250 (100%)
Query: 1 MARGDAGRGRGLLALTFCLLAARGELLLPQETTVELSCGVGPLQVILGPEQAAVLNCSLG 60
MARGDAGRGRGLLALTFCLLAARGELLLPQETTVELSCGVGPLQVILGPEQAAVLNCSLG
Sbjct: 1 MARGDAGRGRGLLALTFCLLAARGELLLPQETTVELSCGVGPLQVILGPEQAAVLNCSLG 60
Query: 61 AAAAGPPTRVTWSKDGDTLLEHDHLHLLPNGSLWLSQPLAPNGSDESVPEAVGVIEGNYS 120
AAAAGPPTRVTWSKDGDTLLEHDHLHLLPNGSLWLSQPLAPNGSDESVPEAVGVIEGNYS
Sbjct: 61 AAAAGPPTRVTWSKDGDTLLEHDHLHLLPNGSLWLSQPLAPNGSDESVPEAVGVIEGNYS 120
Query: 121 CLAHGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTARFECHIEGLPAPIITWEKDQ 180
CLAHGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTARFECHIEGLPAPIITWEKDQ
Sbjct: 121 CLAHGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTARFECHIEGLPAPIITWEKDQ 180
Query: 181 VTLPEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTR 240
VTLPEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTR
Sbjct: 181 VTLPEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTR 240
Query: 241 GQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTDVIVLGRTNLLIA 300
GQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTDVIVLGRTNLLIA
Sbjct: 241 GQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTDVIVLGRTNLLIA 300
Query: 301 NAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTARFVCRASG 360
NAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTARFVCRASG
Sbjct: 301 NAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTARFVCRASG 360
Query: 361 EPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAAASL 420
EPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAAASL
Sbjct: 361 EPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAAASL 420
Query: 421 AVVVREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFA 480
AVVVREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFA
Sbjct: 421 AVVVREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFA 480
Query: 481 VNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSSPNP 540
VNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSSPNP
Sbjct: 481 VNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSSPNP 540
Query: 541 SDIRVAWLPLPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVR 600
SDIRVAWLPLPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVR
Sbjct: 541 SDIRVAWLPLPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVR 600
Query: 601 ISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQAKMESLVVSWQPPPHPTQISG 660
ISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQAKMESLVVSWQPPPHPTQISG
Sbjct: 601 ISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQAKMESLVVSWQPPPHPTQISG 660
Query: 661 YKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAF 720
YKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAF
Sbjct: 661 YKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAF 720
Query: 721 NKHEDGYAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKI 780
NKHEDGYAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKI
Sbjct: 721 NKHEDGYAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKI 780
Query: 781 VNYTVRFSPWGLRNASLVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVER 840
VNYTVRFSPWGLRNASLVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVER
Sbjct: 781 VNYTVRFSPWGLRNASLVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVER 840
Query: 841 STLPDRPSTPPSDLRLSPLTPSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLT 900
STLPDRPSTPPSDLRLSPLTPSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLT
Sbjct: 841 STLPDRPSTPPSDLRLSPLTPSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLT 900
Query: 901 TQGNIFSAEVHGLESDTRYFFKMGARTEVGPGPFSRLQDVITLQEKLSDSLDMHSVTGII 960
TQGNIFSAEVHGLESDTRYFFKMGARTEVGPGPFSRLQDVITLQEKLSDSLDMHSVTGII
Sbjct: 901 TQGNIFSAEVHGLESDTRYFFKMGARTEVGPGPFSRLQDVITLQEKLSDSLDMHSVTGII 960
Query: 961 VGVCLGLLCLLACMCAGLRRSPHRESLPGLSSTATPGNPALYSRARLGPPSPPAAHELES 1020
VGVCLGLLCLLACMCAGLRRSPHRESLPGLSSTATPGNPALYSRARLGPPSPPAAHELES
Sbjct: 961 VGVCLGLLCLLACMCAGLRRSPHRESLPGLSSTATPGNPALYSRARLGPPSPPAAHELES 1020
Query: 1021 LVHPHPQDWSPPPSDVEDRAEVHSLMGGGVSEGRSHSKRKISWAQPSGLSWAGSWAGCEL 1080
LVHPHPQDWSPPPSDVEDRAEVHSLMGGGVSEGRSHSKRKISWAQPSGLSWAGSWAGCEL
Sbjct: 1021 LVHPHPQDWSPPPSDVEDRAEVHSLMGGGVSEGRSHSKRKISWAQPSGLSWAGSWAGCEL 1080
Query: 1081 PQAGPRPALTRALLPPAGTGQTLLLQALVYDAIKGNGRKKSPPACRNQVEAEVIVHSDFS 1140
PQAGPRPALTRALLPPAGTGQTLLLQALVYDAIKGNGRKKSPPACRNQVEAEVIVHSDFS
Sbjct: 1081 PQAGPRPALTRALLPPAGTGQTLLLQALVYDAIKGNGRKKSPPACRNQVEAEVIVHSDFS 1140
Query: 1141 ASNGNPDLHLQDLEPEDPLPPEAPDLISGVGDPGQGAAWLDRELGGCELAAPGPDRLTCL 1200
ASNGNPDLHLQDLEPEDPLPPEAPDLISGVGDPGQGAAWLDRELGGCELAAPGPDRLTCL
Sbjct: 1141 ASNGNPDLHLQDLEPEDPLPPEAPDLISGVGDPGQGAAWLDRELGGCELAAPGPDRLTCL 1200
Query: 1201 PEAASASCSYPDLQPGEVLEETPGDSCQLKSPCPLGASPGLPRSPVSSSA 1250
PEAASASCSYPDLQPGEVLEETPGDSCQLKSPCPLGASPGLPRSPVSSSA
Sbjct: 1201 PEAASASCSYPDLQPGEVLEETPGDSCQLKSPCPLGASPGLPRSPVSSSA 1250
>gi|83281200 protogenin [Homo sapiens]
Length = 1150
Score = 668 bits (1724), Expect = 0.0
Identities = 393/992 (39%), Positives = 548/992 (55%), Gaps = 63/992 (6%)
Query: 35 ELSCGVGPLQVILGPEQAAVLNCSLGAAAAGPPTRVTWSKDGDTLLEHDHLHLLPNGSLW 94
ELS P V + + VL+C A P +VTW K+G + E+ + +L NGSL+
Sbjct: 38 ELSFVKEPQDVTVTRKDPVVLDCQ---AHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLY 94
Query: 95 LSQPLAPNGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLADFSLHPESQTV 154
+S+ G EG Y CLA G + SQ A + L+T++ F + P S V
Sbjct: 95 ISEVEGRRGEQSD--------EGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPISTEV 146
Query: 155 EENGTARFECHIEGLPAPIITWEKDQVTLPEE-PRLIVLPNGVLQILDVQESDAGPYRCV 213
E G ARF C I P +ITWE ++ TLP R+ LP GVLQI DV + D+G YRC+
Sbjct: 147 HEGGVARFACKISSHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCI 206
Query: 214 ATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTP 273
A A + S EA L+V + S I+A P+N T Q+VV+EC+A+ +P P
Sbjct: 207 AATVAHRRKSMEASLTVIP--AKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKP 264
Query: 274 FVSWVRQDGKPIST-DVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVL 332
+SW R D K I + VLG NL+I++ + H+GVYVCRA P TR+F A A L VL
Sbjct: 265 IISWSRLDHKSIDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVL 324
Query: 333 AAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVI 392
A P+ + PE+L+R RA TARFVC+A G P P + WL NG + NGR+K+ LVI
Sbjct: 325 APPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHSNGRIKMYNS--KLVI 382
Query: 393 TQIGLQDAGYYQCVAENSAGMACAAASLAVVVREGLPSAPTRVTATPLSSSAVLVAWERP 452
QI +D YQC+AENS G + A L VV+ E PSAP V A +SSSA+L+AWERP
Sbjct: 383 NQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPSAPYNVHAETMSSSAILLAWERP 442
Query: 453 EMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGAS 512
+S+++I +S+HY KA G++N EYQ + NDTT + DLEP ++Y FY+VAY +GAS
Sbjct: 443 LYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGAS 502
Query: 513 RTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKED 572
+ S +TL+DVP P++SL+S +P+DI ++WLP+P GQVV Y++ + L E+
Sbjct: 503 QMSDHVTQNTLEDVPLRPPEISLTSRSPTDILISWLPIPAKYRRGQVVLYRLSFRLSTEN 562
Query: 573 QIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFA 632
I E+ G + +L L+P+ VY VRI+A T G G S W HRTP P +
Sbjct: 563 SIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRTPKA-TSVKAPKS 621
Query: 633 PAELKVQAKMESLVVSWQPPPHPT-QISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVG 691
P ++ V WQ T I GYKLY++E G +E G
Sbjct: 622 PELHLEPLNCTTISVRWQQDVEDTAAIQGYKLYYKEEGQQEN-----------------G 664
Query: 692 PVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQR--GP 749
P+ L K Y L+ L P R Y V+L+A+N +DGY A +T P R P
Sbjct: 665 PIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQA---DQTVSTPGCVSVRDRMVPP 721
Query: 750 PLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRFSPWGLRNASLVTYYTSSGEDIL 809
P PP H++A++N+S+SI+L W++P FT +I+NYT+R +P GL+NASLV Y +S +L
Sbjct: 722 PPPPHHLYAKANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTSETHML 781
Query: 810 IGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRLSPLTPSTVRLHWC 869
+ GL+P TKYEFAV+ H + P+ VV STLP+ P+ PP ++++ + T + W
Sbjct: 782 VQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSWK 841
Query: 870 PPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESDTRYFFKMGARTEV 929
PP P + Y ILY+S +W +L +G I A + L + Y K+ A EV
Sbjct: 842 PPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGNVYIVKISASNEV 901
Query: 930 GPGPFSRLQDVITLQEKLSDS--------------------LDMHSVTGIIVGVCLGLLC 969
G GPFS ++ L ++ S+S LD S+TGI VGV + L C
Sbjct: 902 GEGPFSNSVELAVLPKETSESNQRPKRLDSADAKVYSGYYHLDQKSMTGIAVGVGIALTC 961
Query: 970 LLACMCAGLRRSPHRESLPGLSSTATPGNPAL 1001
+L C+ + RS R+S S TA G L
Sbjct: 962 ILICVLILIYRSKARKS--SASKTAQNGTQQL 991
>gi|134244585 putative neuronal cell adhesion molecule [Homo
sapiens]
Length = 814
Score = 397 bits (1021), Expect = e-110
Identities = 244/605 (40%), Positives = 334/605 (55%), Gaps = 24/605 (3%)
Query: 10 RGLLALTFCLLAARGELLLPQETTVELSCGVGPLQVILGPEQAAVLNCSLGAAAAGPPTR 69
R LL L LL A E L + EL+ V P + P Q VL+C + PP R
Sbjct: 19 RLLLPLLLLLLPAPSEGL---GHSAELAFAVEPSDDVAVPGQPIVLDCRVEGT---PPVR 72
Query: 70 VTWSKDGDTLLEHDHLHLLPNGSLWLSQ-PLAPNGSDESVPEAVGVIEGNYSCLAHGPLG 128
+TW K+G L E H LL NGSL + L P GS EG+Y C+A G
Sbjct: 73 ITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSD--------EGDYECVAQNRFG 124
Query: 129 VLASQTAVVKLATLADFSLHPESQTVEENGTARFECHIEGLPAPIITWEKDQVTLP-EEP 187
++ S+ A ++ AT++DF +HP++ EE G ARF+C I GLP P+ITWEK++V + +
Sbjct: 125 LVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNE 184
Query: 188 RLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIV 247
R +LP GVLQI ++ D G + CVA+N A S A L+V+ GS A ++ I+
Sbjct: 185 RYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSGSGAY---KEPAIL 241
Query: 248 AAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTDVI-VLGRTNLLIANAQPWH 306
PEN T+ Q+ V+ECVA+ +P P VSW R DG+PI + I VLG NL+I++ H
Sbjct: 242 VGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVLGTGNLIISDVTVQH 301
Query: 307 SGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTARFVCRASGEPRPAL 366
SGVYVC AN+P TR TA L V A Q P+++SR +TA F C+A GEP P +
Sbjct: 302 SGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHV 361
Query: 367 RWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAVVVRE 426
WL NG L P G V+++ +L I+ IG +D YQCVAENSAG + A+A L V+ E
Sbjct: 362 TWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAE 421
Query: 427 GLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTT 486
GLP P V A +SS+ V V+W P ++++IIG+ LH +KA +EYQ AV+ T
Sbjct: 422 GLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTF 481
Query: 487 ELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVA 546
+ V DLEP+T Y FY+ AY+ GAS S P L TL + P A P LS+ S +++
Sbjct: 482 QHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAP-APPPLSVRVLGSSSLQLL 540
Query: 547 WLPLPPSLSNGQVVKYKIEY-GLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGT 605
W P P + +K+ Y K + G + L+ L P VY V++ A
Sbjct: 541 WEPWPRLAQHEG--GFKLFYRPASKTSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYN 598
Query: 606 AAGFG 610
G G
Sbjct: 599 QHGDG 603
Score = 146 bits (369), Expect = 1e-34
Identities = 156/620 (25%), Positives = 246/620 (39%), Gaps = 90/620 (14%)
Query: 145 FSLHPESQTVEENGTARFECHIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQ- 203
F++ P +C +EG P ITW K+ V LPE +L NG L I +
Sbjct: 44 FAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRL 103
Query: 204 -----ESDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSG 258
SD G Y CVA N S++A + A P+ T G
Sbjct: 104 EPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFH----------VHPQATVGEEG 153
Query: 259 QSVVMECVASADPTPFVSWVRQDGKPISTD---VIVLGRTNLLIANAQPWHSGVYVCRAN 315
+C P P ++W ++ PI TD +L + L I + G++ C A+
Sbjct: 154 GVARFQCQIHGLPKPLITW-EKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVAS 212
Query: 316 KPRTRDFATAAAELRVLAA-------PAITQAPEALSRTRASTARFVCRASGEPRPALRW 368
+ + A L V + PAI PE L+ T TA C A+G PRP + W
Sbjct: 213 NIASIRISHGA-RLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSW 271
Query: 369 LH-NGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAVVVREG 427
+G P+ G ++V G G +L+I+ + +Q +G Y C A A +VV+
Sbjct: 272 SRLDGRPIGVEG-IQVLGTG-NLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQ-- 327
Query: 428 LPSAPTRVTATPLSSSA--------VLVAWERPEMH-----SEQIIGFSLHYQKARGMDN 474
AP P S S A P H + Q++G H +
Sbjct: 328 ---APAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVR------- 377
Query: 475 VEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLS 534
+ N+ + L + + P + + VA + G+S+ S V + +P +
Sbjct: 378 ------LKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVR 431
Query: 535 LSSPNPSDIRVAWLPLPPSLSNGQVVKY--KIEYGLGKEDQIFSTEVRGNETQLMLNSLQ 592
S + +++RV+W P + +++ Y I + + V + Q +++ L+
Sbjct: 432 AVSVSSTEVRVSWSE--PLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLE 489
Query: 593 PNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQAK-MESLVVSWQP 651
P+ Y I A T G + S P++ + AP L V+ SL + W+P
Sbjct: 490 PSTAYSFYIKAYTPRGASSAS------VPTLASTLGEAPAPPPLSVRVLGSSSLQLLWEP 543
Query: 652 PPHPTQISG-YKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPG 710
P Q G +KL++R GP+ L V Y L+QL P
Sbjct: 544 WPRLAQHEGGFKLFYRPASKTSFT----------------GPILLPGTVSSYNLSQLDPT 587
Query: 711 RLYEVKLVAFNKHEDGYAAV 730
+YEVKL+A+N+H DG A V
Sbjct: 588 AVYEVKLLAYNQHGDGNATV 607
Score = 72.8 bits (177), Expect = 2e-12
Identities = 187/834 (22%), Positives = 289/834 (34%), Gaps = 181/834 (21%)
Query: 356 CRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQ------DAGYYQCVAEN 409
CR G P + W NG L P GSL+I L+ D G Y+CVA+N
Sbjct: 63 CRVEGTPPVRITWRKNGVEL-PESTHSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQN 121
Query: 410 SAGMACA------AASL--------AVVVREGLPSAPTRVTATPLSSSAVLVAWERPEMH 455
G+ + AA++ A V EG R L+ WE+ +
Sbjct: 122 RFGLVVSRKARIQAATMSDFHVHPQATVGEEG---GVARFQCQIHGLPKPLITWEKNRVP 178
Query: 456 SEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVA---------- 505
+ DN Y LQ+ L F+ VA
Sbjct: 179 IDT--------------DNERYTLLPKG---VLQITGLRAEDGGIFHCVASNIASIRISH 221
Query: 506 -----YSQLGASRTSTPALVHTLDDVPSAAPQLSL----SSPNPSDIRVAWLPLPPSLSN 556
S G+ PA++ +++ Q ++ ++ NP I V+W L +
Sbjct: 222 GARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPI-VSWSRL-----D 275
Query: 557 GQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWM 616
G+ + + LG + I S + + + +P RVR +A AP++++
Sbjct: 276 GRPIGVEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGT--RVRRTAQGRLVVQAPAEFV 333
Query: 617 HHRTPSMHNQSHVPFAPAELKVQAKMESLVVSWQPPPHPTQISGYKLYWREVGAEEEANG 676
H + S A QA+ E PPPH T + NG
Sbjct: 334 QHP----QSISRPAGTTAMFTCQAQGE-------PPPHVTWLK---------------NG 367
Query: 677 DRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTE 736
L G G VRLK ++ + P + VA N G ++
Sbjct: 368 QVLGPG--------GHVRLKNNNSTLTISGIGPEDEAIYQCVAENS---------AGSSQ 410
Query: 737 KAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRF----SPWGL 792
+ + G P PP +V A S SST + + W +P T +I+ Y + P L
Sbjct: 411 ASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPEL 470
Query: 793 RNASLVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPS 852
V+ T L+ L+P T Y F ++++ STL + P+ PP
Sbjct: 471 EYQEAVSKSTFQH---LVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPL 527
Query: 853 DLRLSPLTPSTVRLHWCP----PTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSA 908
+R+ L S+++L W P G + Y ++ T P + G + S
Sbjct: 528 SVRV--LGSSSLQLLWEPWPRLAQHEGGFKLFYRPASKTSFTGP------ILLPGTVSSY 579
Query: 909 EVHGLESDTRYFFKMGARTEVGPGPFS-RLQDVITLQEKLS----------DSLDMHSVT 957
+ L+ Y K+ A + G G + R + E+ + ++ + S T
Sbjct: 580 NLSQLDPTAVYEVKLLAYNQHGDGNATVRFVSLRGASERTALSPPCDCRKEEAANQTSTT 639
Query: 958 GIIVGVCLGLLCLLACMCAGLRRSPHRESL-----------PGLSSTATPGNPALY---- 1002
GI++G+ +G+ C++ C+ L R L G S PG AL
Sbjct: 640 GIVIGIHIGVTCIIFCVLFLLFGQRGRVLLCKDVENQLSPPQGPRSQRDPGILALNGARR 699
Query: 1003 -SRARLGPPSPPA-AHELESLVHPHPQDWSPPPSDVEDRA----------EVHSLMGGGV 1050
R +LG ELE L P P P +D A V L G G+
Sbjct: 700 GQRGQLGRDEKRVDMKELEQLFPPASAAGQPDPRPTQDPAAPAPCEETQLSVLPLQGCGL 759
Query: 1051 SEGRSHSKRKISWAQPSGLSWAGSWAGCELPQAGP---------RPALTRALLP 1095
EG++ + P AG A P GP RPA R P
Sbjct: 760 MEGKTTEAKTTEATAPC----AGLAAAPPPPDGGPGLLSEGQASRPAAARVTQP 809
>gi|157311649 neogenin homolog 1 [Homo sapiens]
Length = 1461
Score = 271 bits (692), Expect = 4e-72
Identities = 261/959 (27%), Positives = 393/959 (40%), Gaps = 113/959 (11%)
Query: 53 AVLNCSLGAAAAGPPTRVTWSKDGDTLLEHDHLHLLPNGSLWLSQPLAPNGSDESVPEAV 112
A+LNC + A V W ++ LL D + LP+G L +S +G
Sbjct: 169 AILNCEVNADLV---PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDG--------- 216
Query: 113 GVIEGNYSCLAHGPLGVLASQTAVVKLATLAD--------FSLHPESQTVEENGTARFEC 164
G Y C+ G + V+L L D F P C
Sbjct: 217 ----GLYRCVVES--GGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPC 270
Query: 165 HIEGLPAPIITWEKDQVTLPEEP--RLIVLPNGVLQILDVQESDAGPYRCVATNSARQHF 222
GLP P I W K++ L E RL++L G L+I DV E DAG Y C+A N
Sbjct: 271 VASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIE 330
Query: 223 SQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDG 282
+Q L A L P N +V EC + PTP V WV+
Sbjct: 331 AQAELTVQAQPEFLKQ-----------PTNIYAHESMDIVFECEVTGKPTPTVKWVKNGD 379
Query: 283 KPISTDVI-VLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLA-APAIT-- 338
I +D ++ NL + G Y C A A A A+L +L APA T
Sbjct: 380 MVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGN--AQAGAQLIILEHAPATTGP 437
Query: 339 --QAPEALSRTRASTARFVCRASGEPRP---------ALRWLHNGAPLRPNGRVKVQGGG 387
AP + + ST RF+ P ++ + G RV+
Sbjct: 438 LPSAPRDVVASLVST-RFIKLTWRTPASDPHGDNLTYSVFYTKEGIARE---RVENTSHP 493
Query: 388 GSLVITQIGLQDAGYY--QCVAENSAGMACAAASLAVVVREG--LPSAPTRVTATPLSSS 443
G + +T L A Y + +A+N G ++A L V + LP + A S +
Sbjct: 494 GEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPT 553
Query: 444 AVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYV 503
++ V WE P + +I + L+Y + +G D + V+ + + L+ T+Y F V
Sbjct: 554 SITVTWETPVSGNGEIQNYKLYYME-KGTDKEQ---DVDVSSHSYTINGLKKYTEYSFRV 609
Query: 504 VAYSQLGASRTSTPALVHTLDDVPSAAPQ-LSLSSPNPSDIRVAWLPLPPSLSNGQVVKY 562
VAY++ G ++ V TL DVPSAAPQ LSL N I + W P P+ NGQ+ Y
Sbjct: 610 VAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGY 669
Query: 563 KIEYG-LGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRT- 620
KI Y ++ + T V G + ++ L Y R++A T G G + W+ T
Sbjct: 670 KIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETF 729
Query: 621 PSMHNQSHVPFAPAELKVQAKMESLVVSWQPPPHPT-QISGYKLYWREVGAEEEANGDRL 679
S +++ VP P+ L V+ + S+VVSW PP + + GY +
Sbjct: 730 ESDLDETRVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAI---------------- 773
Query: 680 PGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGY----AAVWKGKT 735
G G + +++ K + Y + L P Y + L AFN +G +AV + T
Sbjct: 774 --GYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHT 831
Query: 736 EKAP-------APDMPIQRGPPL-PPAHVHAESNSSTSIWLRWKKPDFTTVKIVN----Y 783
+ + AP P+ P+ PP V A S +I + W + + Y
Sbjct: 832 DTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYY 891
Query: 784 TVRFSPWGLRNASLVTYYTSSGEDI--LIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERS 841
TVR W + Y ++ + L+ GLKP T YEF+V + +
Sbjct: 892 TVR---WKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGT 948
Query: 842 TLPDRPSTPPSDLRLSPLT--PSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLL 899
T P++PP D+ + P T+ ++W PP+E NG+I Y+I YS++ H W +
Sbjct: 949 TFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIE 1008
Query: 900 TTQGNIFSAEVHGLESDTRYFFKMGARTEVGPGPFSRLQDVITLQEKLSDSLDMHSVTG 958
GN + ++ L DT Y+FK+ AR G GP S T + SD + +G
Sbjct: 1009 PVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASG 1067
Score = 255 bits (652), Expect = 2e-67
Identities = 251/932 (26%), Positives = 409/932 (43%), Gaps = 106/932 (11%)
Query: 40 VGPLQVILGPEQAAVLNCSLGAAAAGPPTRVTWSKDGD--TLLEHDHLHLLPNGSLWLSQ 97
V P+ + + +LNCS A + P ++ W KDG L+ D LLP+GSL++S
Sbjct: 57 VEPVDTLSVRGSSVILNCS---AYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISN 113
Query: 98 PLAPNGSDESVPEAVGVIEGNYSCLAH-GPLGVLASQTAVVKLATLADFSLHPESQTVEE 156
+ S + P+ EG Y C+A LG + S+TA + +A L F+ PE +V
Sbjct: 114 VVH---SKHNKPD-----EGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYA 165
Query: 157 NGTARFECHIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCVATN 216
A C + P + WE+++ L + R+I LP+G+L I + E D G YRCV +
Sbjct: 166 GNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVES 225
Query: 217 SARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVS 276
+S E L V + S D+V + P V GQ VV+ CVAS PTP +
Sbjct: 226 GGPPKYSDEVELKVLPDPEVIS----DLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIK 281
Query: 277 WVRQD---GKPISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLA 333
W++ + S +++L +L I++ +G Y C A+ + A AEL V A
Sbjct: 282 WMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIAD--NGNETIEAQAELTVQA 339
Query: 334 APAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVIT 393
P + P + + F C +G+P P ++W+ NG + P+ K+ +L +
Sbjct: 340 QPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIV-KEHNLQVL 398
Query: 394 QIGLQDAGYYQCVAENSAGMACAAASLAVV-----VREGLPSAPTRVTATPLSSSAVLVA 448
+ D G+YQC+AEN G A A A L ++ LPSAP V A+ +S+ + +
Sbjct: 399 GLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLT 458
Query: 449 WERP--EMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAY 506
W P + H + + +S+ Y K G+ + + ++ +++L P T Y F V+A
Sbjct: 459 WRTPASDPHGDNLT-YSVFYTK-EGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQ 516
Query: 507 SQLGASRTSTPALVHTLDDV--PSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKI 564
++ G+ +S P V T +V P AP L + +P+ I V W P NG++ YK+
Sbjct: 517 NKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTW--ETPVSGNGEIQNYKL 574
Query: 565 EY---GLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTP 621
Y G KE +V + +N L+ Y R+ A G G + + RT
Sbjct: 575 YYMEKGTDKEQ-----DVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRT- 628
Query: 622 SMHNQSHVP-FAPAELKVQAK-MESLVVSWQPPPHPT---QISGYKLYWREVGAEEEANG 676
S VP AP L ++ + +S+++ WQPP T QI+GYK+ +R+ + +
Sbjct: 629 ----LSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTE 684
Query: 677 DRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTE 736
+ G + Q + L G Y ++ A + G A W +
Sbjct: 685 TLVSGTQLSQL----------------IEGLDRGTEYNFRVAALTINGTGPATDW--LSA 726
Query: 737 KAPAPDMPIQRGPPLPPA-HVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRFSPWGLRNA 795
+ D+ R P +P + HV TSI + W P+ + + Y + + G +A
Sbjct: 727 ETFESDLDETRVPEVPSSLHVRP---LVTSIVVSWTPPENQNIVVRGYAIGYG-IGSPHA 782
Query: 796 SLV------TYYTSSGED---ILIGGLKPFTK-------YEFAVQSHGVDMDGPFGSVVE 839
+ YYT D + LK F YE AV D V+
Sbjct: 783 QTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVIN 842
Query: 840 R--STLPD-RPSTPPSDLRLSPLTPSTVRLHWCPPTEPNGEIVE----YLILYSSN-HTQ 891
+ +PD P PP ++ S L+ T+R+ W + P + + Y + + +N
Sbjct: 843 APYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPAN 902
Query: 892 PEHQWTLLTTQGNIFSAEVHGLESDTRYFFKM 923
+++ TT S V GL+ +T Y F +
Sbjct: 903 TKYKNANATT----LSYLVTGLKPNTLYEFSV 930
Score = 171 bits (433), Expect = 4e-42
Identities = 215/857 (25%), Positives = 335/857 (39%), Gaps = 136/857 (15%)
Query: 132 SQTAVVKLATLADFSLHPESQTVEENGTARFECHIEGLPAPIITWEKDQ--VTLPEEPRL 189
S A ++ T F + P + C P+P I W+KD + L + R
Sbjct: 42 SPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRR 101
Query: 190 IVLPNGVLQILDVQES-----DAGPYRCVAT-NSARQHFSQEALLSVAHRGSLASTRGQD 243
+LP+G L I +V S D G Y+CVAT S S+ A L VA S
Sbjct: 102 QLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTS----- 156
Query: 244 VVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTD--VIVLGRTNLLIAN 301
PE ++V +G + ++ C +AD PFV W Q+ +P+ D VI L L+I+N
Sbjct: 157 -----QPEPSSVYAGNNAILNCEVNADLVPFVRW-EQNRQPLLLDDRVIKLPSGMLVISN 210
Query: 302 AQPWHSGVYVC---RANKPRTRDFATAAAELRVLAAPAI------TQAPEALSRTRASTA 352
A G+Y C P+ D EL+VL P + + P L R
Sbjct: 211 ATEGDGGLYRCVVESGGPPKYSD----EVELKVLPDPEVISDLVFLKQPSPLVRVIGQDV 266
Query: 353 RFVCRASGEPRPALRWLHNGAPLRPNGRVK-VQGGGGSLVITQIGLQDAGYYQCVAENSA 411
C ASG P P ++W+ N L + V GGSL I+ + DAG Y C+A+N
Sbjct: 267 VLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGN 326
Query: 412 GMACAAASLAVVVREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARG 471
A A L V + PT + A H I F + G
Sbjct: 327 ETIEAQAELTVQAQPEFLKQPTNIYA-----------------HESMDIVFEC---EVTG 366
Query: 472 MDNVEYQFAVNNDTT------------ELQVRDLEPNTDYEFYVVAYSQLGASRTSTPAL 519
++ N D LQV L + + + +A + +G ++ +
Sbjct: 367 KPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLI 426
Query: 520 V-----HTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEY---GLGKE 571
+ T +PSA + S + I++ W P S +G + Y + Y G+ +E
Sbjct: 427 ILEHAPATTGPLPSAPRDVVASLVSTRFIKLTW-RTPASDPHGDNLTYSVFYTKEGIARE 485
Query: 572 DQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRT-PSMHNQSHVP 630
++ +T G E Q+ + +L P VY R+ A G G S + T P + P
Sbjct: 486 -RVENTSHPG-EMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAP 543
Query: 631 FAPAELKVQAKMESLVVSWQPPPHPT-QISGYKLYWREVGAEEEANGDRLPGGRGDQAWD 689
A A S+ V+W+ P +I YKLY+ E G ++E + D
Sbjct: 544 NLRA---YAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVD------------ 588
Query: 690 VGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQRGP 749
Y + L Y ++VA+NKH G + PD+ ++
Sbjct: 589 -------VSSHSYTINGLKKYTEYSFRVVAYNKHGPGVS-----------TPDVAVRTLS 630
Query: 750 PLP---PAHVHAESNSSTSIWLRWKKPDFTTV--KIVNYTVRFSPWGLRNASLVTYYTSS 804
+P P ++ E +S SI + W+ P T +I Y +R+ ++ T + +
Sbjct: 631 DVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGT 690
Query: 805 GEDILIGGLKPFTKYEFAVQSHGVDMDGP---------FGSVVERSTLPDRPSTPPSDLR 855
LI GL T+Y F V + ++ GP F S ++ + +P+ PS L
Sbjct: 691 QLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPE----VPSSLH 746
Query: 856 LSPLTPSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLES 915
+ PL S V + W PP N + Y I Y P Q + + ++ E L+
Sbjct: 747 VRPLVTSIV-VSWTPPENQNIVVRGYAIGYGIG--SPHAQTIKVDYKQRYYTIE--NLDP 801
Query: 916 DTRYFFKMGARTEVGPG 932
+ Y + A VG G
Sbjct: 802 SSHYVITLKAFNNVGEG 818
>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
Length = 1447
Score = 250 bits (639), Expect = 5e-66
Identities = 265/925 (28%), Positives = 393/925 (42%), Gaps = 117/925 (12%)
Query: 54 VLNCSLGAAAAGPPTRVTWSKDGDTLL--EHDHLHLLPNGSLWLSQPLAPNGSDESVPEA 111
+L+CS + P + W KDG L + L NGSL + L S P+
Sbjct: 58 LLDCSAESDRGVPV--IKWKKDGIHLALGMDERKQQLSNGSLLIQNILH---SRHHKPD- 111
Query: 112 VGVIEGNYSCLAH-GPLGVLASQTAVVKLATLADFSLHPESQTVEENGTARFECHIEGLP 170
EG Y C A G G + S+TA V +A F ES T T +C + G P
Sbjct: 112 ----EGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEP 167
Query: 171 APIITWEKDQ---VTLPEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEAL 227
P I W+K+Q +P + R++VLP+G LQI +Q D G YRC A N A EA
Sbjct: 168 MPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAE 227
Query: 228 LSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPI-- 285
+ + L + + + P N + G+ V+EC S P P +W+R G+ +
Sbjct: 228 VRILSDPGL----HRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLR--GEEVIQ 281
Query: 286 --STDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEA 343
S +LG +NLLI+N SG+Y C + +A+AEL VL P P
Sbjct: 282 LRSKKYSLLGGSNLLISNVTDDDSGMYTCVVT--YKNENISASAELTVLVPPWFLNHPSN 339
Query: 344 LSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYY 403
L + F C SG+P P + W+ NG + P+ ++ GG +L I + D G+Y
Sbjct: 340 LYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIV-GGSNLRILGVVKSDEGFY 398
Query: 404 QCVAENSAGMACAAASL-----AVVVREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQ 458
QCVAEN AG A +A L A+ LPSAP V +SS V ++W P
Sbjct: 399 QCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGN 458
Query: 459 IIGFSLHYQKARGMDNVEYQF-AVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTP 517
I F++ + +R DN E + +L V +L+P Y F VVAY++ G +S P
Sbjct: 459 IQTFTVFF--SREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQP 516
Query: 518 ALVHTLDD--VPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKI---EYGLGKED 572
V T + VP L S +P+ I + W PP+ +NG V Y++ E GKE
Sbjct: 517 IKVATQPELQVPGPVENLQAVSTSPTSILITW--EPPAYANGPVQGYRLFCTEVSTGKEQ 574
Query: 573 QIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFA 632
I EV G L L+ Y +R A G G + + ++ S VP A
Sbjct: 575 NI---EVDG--LSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDI-----TVVTLSDVPSA 624
Query: 633 PAE---LKVQAKMESLVVSWQPPPHPTQ---ISGYKLYWREVGAEEEANGDRLPGGRGDQ 686
P + L+V S+ VSW PPP TQ I+GYK+ R+ E
Sbjct: 625 PPQNVSLEV-VNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEME----------- 672
Query: 687 AWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQ 746
L+ Y T L G Y ++ A + G + W T + P D+
Sbjct: 673 -------TLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNW--YTAETPENDLDES 723
Query: 747 RGPPLPPA-HVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRF---SPWG--LRNASLVTY 800
+ P P + HV ++N I + W P + + Y + + SP+ +R S Y
Sbjct: 724 QVPDQPSSLHVRPQTN---CIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRY 780
Query: 801 YT-----SSGEDILIGGLKPFTK-------YEFAVQSHGVDMDGP--FGSVVE--RSTLP 844
Y+ SS ++ LK F YE A D P + +++ +++P
Sbjct: 781 YSIERLESSSHYVI--SLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVP 838
Query: 845 D--RPSTPPSDLRLSPLTPSTVRLHWC----PPTEPNGEIVEYLILYSSNHTQPEHQWTL 898
D P PP ++ LT VR+ W P + E+ Y + + ++ + +
Sbjct: 839 DLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSE 898
Query: 899 LTTQGNIFSAEVHGLESDTRYFFKM 923
TT S GL+ +T Y F +
Sbjct: 899 DTTS---LSYTATGLKPNTMYEFSV 920
Score = 226 bits (576), Expect = 1e-58
Identities = 226/921 (24%), Positives = 360/921 (39%), Gaps = 104/921 (11%)
Query: 66 PPTRVTWSKDGDTLLE---HDHLHLLPNGSLWLSQPLAPNGSDESVPEAVGVIEGNYSCL 122
P + W K+ L + +LP+G+L +S+ P +G+ Y C
Sbjct: 167 PMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISR---------LQPGDIGI----YRCS 213
Query: 123 AHGPLGVLASQTAVVKLATLADFSLH--------PESQTVEENGTARFECHIEGLPAPII 174
A P A V++ L+D LH P + E A EC + G P P
Sbjct: 214 ARNPASSRTGNEAEVRI--LSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSF 271
Query: 175 TWEK-DQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEALLSVAHR 233
TW + ++V + +L L I +V + D+G Y CV T ++ S A L+V
Sbjct: 272 TWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYK-NENISASAELTVL-- 328
Query: 234 GSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTDVI-VL 292
+ P N + EC S P P V+W++ I +D ++
Sbjct: 329 --------VPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIV 380
Query: 293 GRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTR---- 348
G +NL I G Y C A A +A+L ++ PAI + S R
Sbjct: 381 GGSNLRILGVVKSDEGFYQCVAENEAGN--AQTSAQL-IVPKPAIPSSSVLPSAPRDVVP 437
Query: 349 -ASTARFV-------CRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDA 400
++RFV A G + + R Q G L + + +
Sbjct: 438 VLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAM 497
Query: 401 GYYQCVAENSAGMACAAASLAVVVREGL--PSAPTRVTATPLSSSAVLVAWERPEMHSEQ 458
++ VA N G ++ + V + L P + A S +++L+ WE P +
Sbjct: 498 YTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGP 557
Query: 459 IIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPA 518
+ G+ L + + + + D ++ L+ T+Y +AY++ G ++
Sbjct: 558 VQGYRLFCTEV----STGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDI 613
Query: 519 LVHTLDDVPSAAPQ-LSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKEDQIFST 577
V TL DVPSA PQ +SL N I+V+WLP P NG + YKI + T
Sbjct: 614 TVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMET 673
Query: 578 EVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMH-NQSHVPFAPAEL 636
+ N + L+ Y ++SA T G G PS W TP ++S VP P+ L
Sbjct: 674 -LEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSL 732
Query: 637 KVQAKMESLVVSWQPPPHPT-QISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRL 695
V+ + +++SW PP +P + GY + G G + VR+
Sbjct: 733 HVRPQTNCIIMSWTPPLNPNIVVRGYII------------------GYGVGSPYAETVRV 774
Query: 696 KKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQ--------- 746
K + Y + +L Y + L AFN +G T P P+
Sbjct: 775 DSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFP 834
Query: 747 ------RGPPLPPAHVHAESNSSTSIWLRWKKPDFT----TVKIVNYTVRFSPWGLRNAS 796
P LPP V A + + ++ + W T ++ YTVR+ +A
Sbjct: 835 TSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAK 894
Query: 797 LVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRL 856
+ T+S GLKP T YEF+V + +T P++ P DL +
Sbjct: 895 YKSEDTTS-LSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTV 953
Query: 857 SPLT--PSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLE 914
P V + W PP E NG+I Y++ Y+ + P W + T G+ + ++ L
Sbjct: 954 ITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLN 1013
Query: 915 SDTRYFFKMGARTEVGPGPFS 935
DT Y+F++ AR G GP S
Sbjct: 1014 LDTMYYFRIQARNSKGVGPLS 1034
Score = 79.0 bits (193), Expect = 3e-14
Identities = 77/333 (23%), Positives = 136/333 (40%), Gaps = 32/333 (9%)
Query: 621 PSMHNQSHVPFAPAEL-KVQAKMESLVVSWQPPPHPT-QISGYKLYW-REVGAEEEANGD 677
P++ + S +P AP ++ V + +SW+PP I + +++ RE E A
Sbjct: 420 PAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNT 479
Query: 678 RLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEK 737
PG Q + L P +Y ++VA+N+ G ++ +
Sbjct: 480 TQPGSL-----------------QLTVGNLKPEAMYTFRVVAYNEWGPGESSQ---PIKV 519
Query: 738 APAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRFSPWGLRNASL 797
A P++ + P P ++ A S S TSI + W+ P + + Y + +
Sbjct: 520 ATQPELQV----PGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQN 575
Query: 798 VTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRLS 857
+ G + GLK FT+Y ++ G + TL D PS PP ++ L
Sbjct: 576 IEV---DGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLE 632
Query: 858 PLTPSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESDT 917
+ ++++ W PP P+G ++ Y H + + + T + N GLE +
Sbjct: 633 VVNSRSIKVSWLPP--PSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGS 690
Query: 918 RYFFKMGARTEVGPGPFSRLQDVITLQEKLSDS 950
+Y F++ A T G GP S T + L +S
Sbjct: 691 QYSFQVSAMTVNGTGPPSNWYTAETPENDLDES 723
Score = 55.1 bits (131), Expect = 4e-07
Identities = 47/180 (26%), Positives = 79/180 (43%), Gaps = 19/180 (10%)
Query: 247 VAAPENTTVVSGQSVVMECVASAD-PTPFVSWVRQDGKPISTDV----IVLGRTNLLIAN 301
++ P + + G +V+++C A +D P + W ++DG ++ + L +LLI N
Sbjct: 43 LSEPSDAVTMRGGNVLLDCSAESDRGVPVIKW-KKDGIHLALGMDERKQQLSNGSLLIQN 101
Query: 302 AQPWHS-------GVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTARF 354
HS G+Y C A+ + + A++ V E+++ T
Sbjct: 102 I--LHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLL 159
Query: 355 VCRASGEPRPALRWLHNGAPLRP---NGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSA 411
C GEP P + W N L P + RV V G+L I+++ D G Y+C A N A
Sbjct: 160 KCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVL-PSGALQISRLQPGDIGIYRCSARNPA 218
>gi|239741341 PREDICTED: similar to hCG1996527 [Homo sapiens]
Length = 654
Score = 247 bits (630), Expect = 6e-65
Identities = 178/528 (33%), Positives = 250/528 (47%), Gaps = 71/528 (13%)
Query: 50 EQAAVLNCSLGAAAAGPPTRVTWSKDGDTLLEHDHLHLLPNGSLWLSQPLAPNGSDESVP 109
E VL C + PP ++W +D L + L+P+GSL L A S S+P
Sbjct: 33 EHPLVLPCQVEGE---PPVSISWQRDRLALANESGVTLMPDGSLHL----AALPSRRSLP 85
Query: 110 EAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTARFECHIEGL 169
Y C+A G L S+ A V+LA+L+ F HPES VE G ARF+C I+G+
Sbjct: 86 SRAH----EYHCVAQNRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLIQGV 141
Query: 170 PAPIITWEKDQVTL-PEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEALL 228
P P I+WE + L R+ +LP+G+L I V ++D G YRCVA N A SQ+A L
Sbjct: 142 PEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQL 201
Query: 229 SVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTD 288
+++ G L Q+ I++ P+N T+ Q+ V+EC+A++ P P VSW R DG+ I +
Sbjct: 202 TLS-VGPLRLL--QEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVE 258
Query: 289 VI----VLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAEL-------------RV 331
I +L NL+I++ HSGVYVC AN+P T TA L RV
Sbjct: 259 GIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRV 318
Query: 332 LAAPA----------------------------------ITQAPEALSRTRASTARFVCR 357
L P+ Q P++LS+ S+A F C
Sbjct: 319 LEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCV 378
Query: 358 ASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAA 417
A G P L WL NG L P +++ +L++ + ++D YQCVAENS G A+
Sbjct: 379 AQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQAS 438
Query: 418 ASLAVV--VREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNV 475
A L V P P + S+VL A S IIG+ LH +
Sbjct: 439 ARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGA---TPPSSRDIIGYVLHLRPVGEPSGP 495
Query: 476 EYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTL 523
E Q A++ T+E +LEP T Y ++ AYS GAS+ S P T+
Sbjct: 496 ELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFASTM 543
Score = 67.0 bits (162), Expect = 1e-10
Identities = 74/323 (22%), Positives = 128/323 (39%), Gaps = 23/323 (7%)
Query: 241 GQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTD--VIVLGRTNLL 298
G ++ V +T V +V+ C +P +SW R D ++ + V ++ +L
Sbjct: 16 GSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQR-DRLALANESGVTLMPDGSLH 74
Query: 299 IA-----NAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTAR 353
+A + P + Y C A R + A +++ + Q PE++ R AR
Sbjct: 75 LAALPSRRSLPSRAHEYHCVAQNRYGR-LVSRQARVQLASLSRFHQHPESIEVERGGVAR 133
Query: 354 FVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAEN---- 409
F C G P P++ W HNG L G L IT + D G Y+CVA N
Sbjct: 134 FQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAST 193
Query: 410 ----SAGMACAAASLAVVVREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLH 465
A + + L ++ + S P +T T + +AVL H ++ +S
Sbjct: 194 RHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLT-VHQTAVLEC--IATSHPWPLVSWSRL 250
Query: 466 YQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDD 525
++ G++ ++ + DT L + D+ YV A ++ G T V +
Sbjct: 251 DGRSIGVEGIQVLDIL--DTGNLMISDVSVQHS-GVYVCAANRPGTHVRRTAQGVLLVQG 307
Query: 526 VPSAAPQLSLSSPNPSDIRVAWL 548
P + +PS + AW+
Sbjct: 308 EPQGPNWVGRVLEHPSSLTGAWI 330
>gi|169162264 PREDICTED: similar to hCG1996527 [Homo sapiens]
Length = 654
Score = 244 bits (622), Expect = 5e-64
Identities = 177/528 (33%), Positives = 249/528 (47%), Gaps = 71/528 (13%)
Query: 50 EQAAVLNCSLGAAAAGPPTRVTWSKDGDTLLEHDHLHLLPNGSLWLSQPLAPNGSDESVP 109
E VL C + PP ++W +D L + L+P+GSL L A S S+P
Sbjct: 33 EHPLVLPCQVEGE---PPVSISWQRDRLALANESGVTLMPDGSLHL----AALPSRRSLP 85
Query: 110 EAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTARFECHIEGL 169
Y C+A G L S+ A V+LA+L+ F HPES VE G A F+C I+G+
Sbjct: 86 SRAH----EYHCVAQNRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVACFQCLIQGV 141
Query: 170 PAPIITWEKDQVTL-PEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEALL 228
P P I+WE + L R+ +LP+G+L I V ++D G YRCVA N A SQ+A L
Sbjct: 142 PEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQL 201
Query: 229 SVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTD 288
+++ G L Q+ I++ P+N T+ Q+ V+EC+A++ P P VSW R DG+ I +
Sbjct: 202 TLS-VGPLRLL--QEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVE 258
Query: 289 VI----VLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAEL-------------RV 331
I +L NL+I++ HSGVYVC AN+P T TA L RV
Sbjct: 259 GIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRV 318
Query: 332 LAAPA----------------------------------ITQAPEALSRTRASTARFVCR 357
L P+ Q P++LS+ S+A F C
Sbjct: 319 LEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCV 378
Query: 358 ASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAA 417
A G P L WL NG L P +++ +L++ + ++D YQCVAENS G A+
Sbjct: 379 AQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQAS 438
Query: 418 ASLAVV--VREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNV 475
A L V P P + S+VL A S IIG+ LH +
Sbjct: 439 ARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGA---TPPSSRDIIGYVLHLRPVGEPSGP 495
Query: 476 EYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTL 523
E Q A++ T+E +LEP T Y ++ AYS GAS+ S P T+
Sbjct: 496 ELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFASTM 543
Score = 63.9 bits (154), Expect = 9e-10
Identities = 73/323 (22%), Positives = 127/323 (39%), Gaps = 23/323 (7%)
Query: 241 GQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTD--VIVLGRTNLL 298
G ++ V +T V +V+ C +P +SW R D ++ + V ++ +L
Sbjct: 16 GSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQR-DRLALANESGVTLMPDGSLH 74
Query: 299 IA-----NAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTAR 353
+A + P + Y C A R + A +++ + Q PE++ R A
Sbjct: 75 LAALPSRRSLPSRAHEYHCVAQNRYGR-LVSRQARVQLASLSRFHQHPESIEVERGGVAC 133
Query: 354 FVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAEN---- 409
F C G P P++ W HNG L G L IT + D G Y+CVA N
Sbjct: 134 FQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAST 193
Query: 410 ----SAGMACAAASLAVVVREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLH 465
A + + L ++ + S P +T T + +AVL H ++ +S
Sbjct: 194 RHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLT-VHQTAVLEC--IATSHPWPLVSWSRL 250
Query: 466 YQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDD 525
++ G++ ++ + DT L + D+ YV A ++ G T V +
Sbjct: 251 DGRSIGVEGIQVLDIL--DTGNLMISDVSVQHS-GVYVCAANRPGTHVRRTAQGVLLVQG 307
Query: 526 VPSAAPQLSLSSPNPSDIRVAWL 548
P + +PS + AW+
Sbjct: 308 EPQGPNWVGRVLEHPSSLTGAWI 330
>gi|239747467 PREDICTED: similar to hCG1996527 [Homo sapiens]
Length = 654
Score = 244 bits (622), Expect = 5e-64
Identities = 177/528 (33%), Positives = 249/528 (47%), Gaps = 71/528 (13%)
Query: 50 EQAAVLNCSLGAAAAGPPTRVTWSKDGDTLLEHDHLHLLPNGSLWLSQPLAPNGSDESVP 109
E VL C + PP ++W +D L + L+P+GSL L A S S+P
Sbjct: 33 EHPLVLPCQVEGE---PPVSISWQRDRLALANESGVTLMPDGSLHL----AALPSRRSLP 85
Query: 110 EAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTARFECHIEGL 169
Y C+A G L S+ A V+LA+L+ F HPES VE G A F+C I+G+
Sbjct: 86 SRAH----EYHCVAQNRYGRLVSRRARVQLASLSRFHQHPESIEVERGGVACFQCLIQGV 141
Query: 170 PAPIITWEKDQVTL-PEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEALL 228
P P I+WE + L R+ +LP+G+L I V ++D G YRCVA N A SQ+A L
Sbjct: 142 PEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQL 201
Query: 229 SVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTD 288
+++ G L Q+ I++ P+N T+ Q+ V+EC+A++ P P VSW R DG+ I +
Sbjct: 202 TLS-VGPLRLL--QEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVE 258
Query: 289 VI----VLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAEL-------------RV 331
I +L NL+I++ HSGVYVC AN+P T TA L RV
Sbjct: 259 GIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRV 318
Query: 332 LAAPA----------------------------------ITQAPEALSRTRASTARFVCR 357
L P+ Q P++LS+ S+A F C
Sbjct: 319 LEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCV 378
Query: 358 ASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAA 417
A G P L WL NG L P +++ +L++ + ++D YQCVAENS G A+
Sbjct: 379 AQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQAS 438
Query: 418 ASLAVV--VREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNV 475
A L V P P + S+VL A S IIG+ LH +
Sbjct: 439 ARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGA---TPPSSRDIIGYVLHLRPVGEPSGP 495
Query: 476 EYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTL 523
E Q A++ T+E +LEP T Y ++ AYS GAS+ S P T+
Sbjct: 496 ELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFASTM 543
Score = 63.9 bits (154), Expect = 9e-10
Identities = 73/323 (22%), Positives = 127/323 (39%), Gaps = 23/323 (7%)
Query: 241 GQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTD--VIVLGRTNLL 298
G ++ V +T V +V+ C +P +SW R D ++ + V ++ +L
Sbjct: 16 GSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQR-DRLALANESGVTLMPDGSLH 74
Query: 299 IA-----NAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTAR 353
+A + P + Y C A R + A +++ + Q PE++ R A
Sbjct: 75 LAALPSRRSLPSRAHEYHCVAQNRYGR-LVSRRARVQLASLSRFHQHPESIEVERGGVAC 133
Query: 354 FVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAEN---- 409
F C G P P++ W HNG L G L IT + D G Y+CVA N
Sbjct: 134 FQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAST 193
Query: 410 ----SAGMACAAASLAVVVREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLH 465
A + + L ++ + S P +T T + +AVL H ++ +S
Sbjct: 194 RHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLT-VHQTAVLEC--IATSHPWPLVSWSRL 250
Query: 466 YQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDD 525
++ G++ ++ + DT L + D+ YV A ++ G T V +
Sbjct: 251 DGRSIGVEGIQVLDIL--DTGNLMISDVSVQHS-GVYVCAANRPGTHVRRTAQGVLLVQG 307
Query: 526 VPSAAPQLSLSSPNPSDIRVAWL 548
P + +PS + AW+
Sbjct: 308 EPQGPNWVGRVLEHPSSLTGAWI 330
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 194 bits (494), Expect = 3e-49
Identities = 210/828 (25%), Positives = 340/828 (41%), Gaps = 86/828 (10%)
Query: 145 FSLHPESQTVEENGTARFECHIEGLPAPIITW-EKDQVTLPEEPRLIVLPNGVLQILDVQ 203
F P+ Q G A F C G P P +TW +K + + I +L +Q
Sbjct: 35 FIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQ 94
Query: 204 ----ESDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQ 259
D Y CVA NS + + A L+V L S I P+ V +
Sbjct: 95 PLRTPRDENVYECVAQNSVGE-ITVHAKLTVLREDQLPSGFPN---IDMGPQLKVVERTR 150
Query: 260 SVVMECVASADPTPFVSWVRQ----DGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRA- 314
+ M C AS +P P ++W + D + + L L I +++ G Y C A
Sbjct: 151 TATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECVAT 210
Query: 315 NKPRTRDFATAAAELRV-LAAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGA 373
N R + A +RV AP + P + C A G P P ++W+
Sbjct: 211 NSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAE 270
Query: 374 PLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAVVVREGLPSAPT 433
L P + V G V+ ++D+ Y CVA +S G+ A A + V + LP AP
Sbjct: 271 DLTPEDDMPV----GRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV---KSLPKAPG 323
Query: 434 RVTATPLSSSAVLVAWE--RPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVR 491
T +++++ + W+ P+ S +I + K++ D YQ + TT +
Sbjct: 324 TPMVTENTATSITITWDSGNPDPVSYYVIEY-----KSKSQDG-PYQIKEDITTTRYSIG 377
Query: 492 DLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQ-LSLSSPNPSDIRVAW-LP 549
L PN++YE +V A + +G S + T + P++AP+ + + + + V W P
Sbjct: 378 GLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEP 437
Query: 550 LPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGNETQLM--LNSLQPNKVYRVRISAGTAA 607
+ P NG + Y++ Y + E + + + + L+ + SL ++ Y VR+ A T+
Sbjct: 438 VEP---NGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSV 494
Query: 608 GFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQAKME-SLVVSWQPPPHPTQISGYKLYWR 666
G G S + +T Q VP P L+ +A+ E S+ +SW PP + I Y+L +R
Sbjct: 495 GDGPLSDPIQVKT-----QQGVPGQPMNLRAEARSETSITLSWSPPRQESIIK-YELLFR 548
Query: 667 EVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDG 726
E GD +VG R Y + L P Y +L A + G
Sbjct: 549 E----------------GDHGREVG--RTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLG 590
Query: 727 -YAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVK--IVNY 783
+ V + +T +Q P PP V S ST+I + W+ P T +V Y
Sbjct: 591 AFTPVVRQRT---------LQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGY 641
Query: 784 TVRFSPWGLRN--ASLVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERS 841
+VR+ P G + V + IL+ L+ +T+Y +H GP S V
Sbjct: 642 SVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVR 701
Query: 842 TLPDRPSTPPSDLRLSPLTPSTVRLHWCPPT--EPNGEIVEYLILY-----SSNHTQPEH 894
T D PS PP + L + +R+ W P +G+I Y + Y + P
Sbjct: 702 TDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRI 761
Query: 895 QWTLLTTQGNIFSAEVHGLESDTRYFFKMGARTEVGPGPFSRLQDVIT 942
+ +L + + L+ +T Y + A T G G S+ + V+T
Sbjct: 762 KDVMLADAQEMV---ITNLQPETAYSITVAAYTMKGDGARSKPKVVVT 806
Score = 179 bits (453), Expect = 2e-44
Identities = 220/915 (24%), Positives = 364/915 (39%), Gaps = 122/915 (13%)
Query: 62 AAAGPPTRVTWSKDGDTL-------LEHDHLHLLPNGSLWLSQPLAPNGSDESVPEAVGV 114
A P RVTW+K G + +E D G++ QPL DE+V
Sbjct: 56 ATGDPKPRVTWNKKGKKVNSQRFETIEFDE----SAGAVLRIQPLR-TPRDENV------ 104
Query: 115 IEGNYSCLAHGPLGVLASQTAVVKL------ATLADFSLHPESQTVEENGTARFECHIEG 168
Y C+A +G + + L + + + P+ + VE TA C G
Sbjct: 105 ----YECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASG 160
Query: 169 LPAPIITWEKDQVTLPEEP-----RLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFS 223
P P ITW KD LP +P R+ L +G LQI +E+D G Y CVATNSA +S
Sbjct: 161 NPDPEITWFKD--FLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYS 218
Query: 224 QEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGK 283
A L V R P + ++ G +V + CVA P P+V W++
Sbjct: 219 SPANLYVRVRRVAPR-------FSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAED 271
Query: 284 PISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEA 343
D + +GR L + + + S Y C A + A A++ V + P P
Sbjct: 272 LTPEDDMPVGRNVLELTDVK--DSANYTCVAMS--SLGVIEAVAQITVKSLPKAPGTPMV 327
Query: 344 LSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYY 403
T +T+ + SG P P ++ +G +++ + + GL Y
Sbjct: 328 TENT--ATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEY 385
Query: 404 Q--CVAENSAGMACAAASLAVVVREGLP-SAPTRVTATPLSSSAVLVAWERPEMHSEQII 460
+ A NS G + S+ E P SAP V A LS++ ++V WE P + I
Sbjct: 386 EIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIR 445
Query: 461 GFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALV 520
G+ ++Y +Q +D+ V L + Y V+A++ +G S P V
Sbjct: 446 GYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQV 505
Query: 521 HTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKEDQIFSTEVR 580
T VP L + + + I ++W P P S ++KY++ + G +
Sbjct: 506 KTQQGVPGQPMNLRAEARSETSITLSWSP-PRQES---IIKYELLFREGDHGREVG-RTF 560
Query: 581 GNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAELK-VQ 639
T ++ L+PN Y R++A + G GA + + RT QS P ++K V
Sbjct: 561 DPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRT----LQSKPSAPPQDVKCVS 616
Query: 640 AKMESLVVSWQPPP---HPTQISGYKLYWREVGAEE----EANGDRLPGGRGDQAWDVGP 692
+ +++VSW+PPP H + GY + +R +G+E+ E NG
Sbjct: 617 VRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNG---------------- 660
Query: 693 VRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQRGPPLP 752
+ Q L L Y + VA + G E +P + P P
Sbjct: 661 --IPPTTTQILLEALEKWTQYRITTVAHTEVGPG--------PESSPVVVRTDEDVPSAP 710
Query: 753 PAHVHAESNSSTSIWLRWKK--PDFTTVKIVNYTVRF---------SPWGLRNASLVTYY 801
P V AE+ ++T+I + W+ P +I Y V + P +++ L
Sbjct: 711 PRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVML---- 766
Query: 802 TSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGS---VVERSTLPDRPSTPPSDLRLSP 858
+ ++++I L+P T Y V ++ + DG VV + + RP+ L +
Sbjct: 767 -ADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPT-----LSVQQ 820
Query: 859 LTPSTVRLHWCPPT-EPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESDT 917
++ W PP +++ Y + + + P ++ ++ VH
Sbjct: 821 TPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVH---KGA 877
Query: 918 RYFFKMGARTEVGPG 932
Y F++ AR+ G G
Sbjct: 878 TYVFRLAARSRGGLG 892
Score = 167 bits (422), Expect = 8e-41
Identities = 244/943 (25%), Positives = 373/943 (39%), Gaps = 128/943 (13%)
Query: 40 VGPLQVILGPEQAAVLNCSLGAAAAGPPTRVTWSKDG---DTLLEHDHLHLLPNGSLWLS 96
+GP ++ + A + C AA+ P +TW KD D + + L +G+L +
Sbjct: 139 MGPQLKVVERTRTATMLC---AASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIE 195
Query: 97 QPLAPNGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTA--VVKLATLAD-FSLHPESQT 153
S+E+ +G Y C+A GV S A V++ +A FS+ P S
Sbjct: 196 S------SEETD-------QGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHE 242
Query: 154 VEENGTARFECHIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCV 213
+ G C G P P + W + L E + V N VL++ DV+ D+ Y CV
Sbjct: 243 IMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRN-VLELTDVK--DSANYTCV 299
Query: 214 ATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTP 273
A +S EA+ + + SL G +V + T+ S +P P
Sbjct: 300 AMSSLGVI---EAVAQITVK-SLPKAPGTPMVTENTATSITITWD---------SGNPDP 346
Query: 274 FVSWV------RQDGK-PISTDVIVLGRTNLLIANAQP------WHSGVYVCRANKPRTR 320
+V QDG I D+ T I P W S V P +
Sbjct: 347 VSYYVIEYKSKSQDGPYQIKEDITT---TRYSIGGLSPNSEYEIWVSAVNSIGQGPP-SE 402
Query: 321 DFATAAAELRVLAAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGR 380
T E +AP QA + T +G R R + P P G
Sbjct: 403 SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIR-GYRVYYTMEPEHPVGN 461
Query: 381 VKVQGGGGSLVITQIG--LQDAGY-YQCVAENSAGMACAAASLAVVVREGLPSAPTRVTA 437
+ SL +T +G L+D Y + +A S G + + V ++G+P P + A
Sbjct: 462 WQKHNVDDSL-LTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRA 520
Query: 438 TPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNT 497
S +++ ++W P E II + L +++ V F + TT V DL+PNT
Sbjct: 521 EARSETSITLSWSPPRQ--ESIIKYELLFREGDHGREVGRTF---DPTTSYVVEDLKPNT 575
Query: 498 DYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQ-LSLSSPNPSDIRVAWLPLPPSLSN 556
+Y F + A S G + TL PSA PQ + S + I V+W P PP N
Sbjct: 576 EYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHN 635
Query: 557 GQVVKYKIEYG-LGKEDQIFSTEVRG---NETQLMLNSLQPNKVYRVRISAGTAAGFGAP 612
G +V Y + Y LG ED EV G TQ++L +L+ YR+ A T G G
Sbjct: 636 GALVGYSVRYRPLGSEDPE-PKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPE 694
Query: 613 SQWMHHRTPSMHNQSHVPFAPAELKVQAKM---ESLVVSWQPPP---HPTQISGYKLYW- 665
S + RT VP AP KV+A+ ++ V W+ P QI GY++++
Sbjct: 695 SSPVVVRT-----DEDVPSAPPR-KVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYV 748
Query: 666 REVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKV----KQYELTQLVPGRLYEVKLVAFN 721
R GAE GP R+K + ++ +T L P Y + + A+
Sbjct: 749 RMEGAEAR-----------------GPPRIKDVMLADAQEMVITNLQPETAYSITVAAYT 791
Query: 722 KHEDGYAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTV-KI 780
DG + P + + +G L + + S+ RW+ P T ++
Sbjct: 792 MKGDGARS----------KPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQV 841
Query: 781 VNYTVRFSPWGLRNASLVTYYTSSGEDILIGGLKPFTK-YEFAVQSHGVDMDGPFGSVVE 839
+ Y ++F + + + S G K T + A +S G G E
Sbjct: 842 LGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRG----GLGEEAAE 897
Query: 840 RSTLP-DRPSTPPSDLRLSP-LTPSTVRLHWCPPT--EPNGEIVEYLI-LYSSNHTQPEH 894
++P D P P L + + TV L W PP E NG IV+Y + + + P
Sbjct: 898 VLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPAR 957
Query: 895 QWTL--LTTQGNIFSAEVHGLESDTRYFFKMGARTEVGPGPFS 935
+ L G + + GL+ DT Y ++ A T GPGPFS
Sbjct: 958 ETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFS 1000
Score = 120 bits (301), Expect = 8e-27
Identities = 128/508 (25%), Positives = 211/508 (41%), Gaps = 61/508 (12%)
Query: 403 YQCVAENSAGMACAAASLAVVVREGLPSAPTR-VTATPLSSSAVLVAWERP--EMHSEQI 459
++ A + G+ + + PSAP + V + S+A+LV+W P E H+ +
Sbjct: 579 FRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGAL 638
Query: 460 IGFSLHYQKARGMDNVEYQF-AVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPA 518
+G+S+ Y+ D + + TT++ + LE T Y VA++++G S+P
Sbjct: 639 VGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPV 698
Query: 519 LVHTLDDVPSAAP-QLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKEDQIFST 577
+V T +DVPSA P ++ + N + IRV W P +GQ+ Y++ Y ++
Sbjct: 699 VVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHY-----VRMEGA 753
Query: 578 EVRG----------NETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQS 627
E RG + ++++ +LQP Y + ++A T G GA S+ P +
Sbjct: 754 EARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSK------PKVVVTK 807
Query: 628 HVPFAPAELKVQAKME-SLVVSWQPPPHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQ 686
L VQ E SL+ W+PP AE++ G RL GR D
Sbjct: 808 GAVLGRPTLSVQQTPEGSLLARWEPPAGT--------------AEDQVLGYRLQFGREDS 853
Query: 687 AWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQ 746
+ + +Y + + G Y +L A ++ G E A +P +
Sbjct: 854 T-PLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLG--------EEAAEVLSIP-E 903
Query: 747 RGPPLPPAHVHAESNSST-SIWLRW--KKPDFTTVKIVNYTVRFSPWGLRNASLVTYYTS 803
P P + A N+S ++ LRW P IV YTV G + T +
Sbjct: 904 DTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETELPA 963
Query: 804 SGED-----ILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRLSP 858
+ E + + GLKP T Y+ V++H GPF V T R P + ++
Sbjct: 964 AAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFL-RDQVSPKNFKVKM 1022
Query: 859 LTPSTVRLHWCPPTEPNGEIVEYLILYS 886
+ ++V L W P N Y I Y+
Sbjct: 1023 IMKTSVLLSWEFPDNYNSP-TPYKIQYN 1049
Score = 91.3 bits (225), Expect = 5e-18
Identities = 106/445 (23%), Positives = 171/445 (38%), Gaps = 60/445 (13%)
Query: 406 VAENSAGMACAAASLAVVVREGLPSAPTR-VTATPLSSSAVLVAWERPEMHSE--QIIGF 462
VA G ++ + V E +PSAP R V A L+++A+ V W P + QI G+
Sbjct: 684 VAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGY 743
Query: 463 SLHYQKARGMDN---VEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPAL 519
+HY + G + + + D E+ + +L+P T Y V AY+ G S P +
Sbjct: 744 QVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKV 803
Query: 520 VHTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKEDQIFSTEV 579
V T V P LS+ + W P P + QV+ Y++++G + + E
Sbjct: 804 VVTKGAV-LGRPTLSVQQTPEGSLLARWEP-PAGTAEDQVLGYRLQFGREDSTPLATLEF 861
Query: 580 RGNETQLMLNSLQPNKVYRVRISAGTAAGFG---APSQWMHHRTPSMHNQSHVPFAPAEL 636
+E + + + Y R++A + G G A + TP H Q E
Sbjct: 862 PPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQI------LEA 915
Query: 637 KVQAKMESLVVSWQPPPHPTQISG----YKLYWREVGAEEEANGDRLPGGRGDQAWDVGP 692
A ++++ W PP P + +G Y + RE GA A LP A +
Sbjct: 916 AGNASAGTVLLRWLPPV-PAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAENA-- 972
Query: 693 VRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQR----- 747
L L P Y++++ + T + P P P R
Sbjct: 973 ---------LTLQGLKPDTAYDLQV--------------RAHTRRGPGPFSPPVRYRTFL 1009
Query: 748 GPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRFSPWGLRNASLVTYYTSSGED 807
+ P + + TS+ L W+ PD NY +P+ ++ L
Sbjct: 1010 RDQVSPKNFKVKMIMKTSVLLSWEFPD-------NYNSP-TPYKIQYNGLTLDVDGRTTK 1061
Query: 808 ILIGGLKPFTKYEFAVQSHGVDMDG 832
LI LKP T Y F + + G + G
Sbjct: 1062 KLITHLKPHTFYNFVLTNRGSSLGG 1086
Score = 78.2 bits (191), Expect = 5e-14
Identities = 138/641 (21%), Positives = 245/641 (38%), Gaps = 94/641 (14%)
Query: 335 PAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQ---GGGGSLV 391
P + P+ A FVC+A+G+P+P + W G + ++ G L
Sbjct: 33 PRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLR 92
Query: 392 ITQIGL-QDAGYYQCVAENSAGMACAAASLAVVVREGLPSAPTRVTATPL--------SS 442
I + +D Y+CVA+NS G A L V+ + LPS + P ++
Sbjct: 93 IQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTA 152
Query: 443 SAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFY 502
+ + A P+ +I F N + + LQ+ E ++
Sbjct: 153 TMLCAASGNPD---PEITWFKDFLPVDPSASNGRIKQLRSG---ALQIESSEETDQGKYE 206
Query: 503 VVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKY 562
VA + G R S+PA ++ V AP+ S+ P +I ++ G + Y
Sbjct: 207 CVATNSAGV-RYSSPANLYVR--VRRVAPRFSIL-PMSHEIMPGGNVNITCVAVGSPMPY 262
Query: 563 KIEYGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPS 622
+++ G ED ++ L L ++ + Y ++ + A +Q P
Sbjct: 263 -VKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTC-VAMSSLGVIEAVAQITVKSLPK 320
Query: 623 MHNQSHVPFAPAELKVQAKMESLVVSWQPPPHPTQISGYKLYWREVGAEEEANGDRLPGG 682
P P + + S+ ++W +P +S Y + ++ +
Sbjct: 321 ------APGTP--MVTENTATSITITWDSG-NPDPVSYYVIEYKSKSQD----------- 360
Query: 683 RGDQAWDVGPVRLKKKVK--QYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPA 740
GP ++K+ + +Y + L P YE+ + A N G P+
Sbjct: 361 --------GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQG-----------PPS 401
Query: 741 PDMPIQRGPPLP---PAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRFSP-------- 789
+ + G P P +V A S+T++ ++W++P I Y V ++
Sbjct: 402 ESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGN 461
Query: 790 WGLRNA--SLVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRP 847
W N SL+T S ED + +T A S G DGP ++ T P
Sbjct: 462 WQKHNVDDSLLTTVGSLLED------ETYTVRVLAFTSVG---DGPLSDPIQVKTQQGVP 512
Query: 848 STPPSDLRLSPLTPSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFS 907
P +LR + +++ L W PP + + I++Y +L+ +H + T S
Sbjct: 513 GQP-MNLRAEARSETSITLSWSPPRQES--IIKYELLFREG----DHGREVGRTFDPTTS 565
Query: 908 AEVHGLESDTRYFFKMGARTEVGPGPFSRLQDVITLQEKLS 948
V L+ +T Y F++ AR+ G G F+ + TLQ K S
Sbjct: 566 YVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPS 606
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 189 bits (480), Expect = 1e-47
Identities = 214/854 (25%), Positives = 346/854 (40%), Gaps = 116/854 (13%)
Query: 145 FSLHPESQTVEENGTARFECHIEGLPAPIITW-EKDQVTLPEEPRLIVLPNGVLQILDVQ 203
F P+ Q G A F C G P P +TW +K + + I +L +Q
Sbjct: 35 FIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQ 94
Query: 204 ----ESDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQ 259
D Y CVA NS + + A L+V L S I P+ V +
Sbjct: 95 PLRTPRDENVYECVAQNSVGE-ITVHAKLTVLREDQLPSGFPN---IDMGPQLKVVERTR 150
Query: 260 SVVMECVASADPTPFVSWVRQDGKPI------------------STDVIVLGRTNLLIAN 301
+ M C AS +P P ++W + D P+ ST + R L I +
Sbjct: 151 TATMLCAASGNPDPEITWFK-DFLPVDPSASNGRIKQLRSETFESTPI----RGALQIES 205
Query: 302 AQPWHSGVYVCRANKPRTRDFATAA----AELRVL--AAPAITQAPEALSRTRASTARFV 355
++ G Y C A +++ A ELR + AP + P +
Sbjct: 206 SEETDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNIT 265
Query: 356 CRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMAC 415
C A G P P ++W+ L P + V G V+ ++D+ Y CVA +S G+
Sbjct: 266 CVAVGSPMPYVKWMQGAEDLTPEDDMPV----GRNVLELTDVKDSANYTCVAMSSLGVIE 321
Query: 416 AAASLAVVVREGLPSAPTRVTATPLSSSAVLVAWE--RPEMHSEQIIGFSLHYQKARGMD 473
A A + V + LP AP T +++++ + W+ P+ S +I + K++ D
Sbjct: 322 AVAQITV---KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEY-----KSKSQD 373
Query: 474 NVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQ- 532
YQ + TT + L PN++YE +V A + +G S + T + P++AP+
Sbjct: 374 G-PYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRN 432
Query: 533 LSLSSPNPSDIRVAW-LPLPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGNETQLM--LN 589
+ + + + V W P+ P NG + Y++ Y + E + + + + L+ +
Sbjct: 433 VQARMLSATTMIVQWEEPVEP---NGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVG 489
Query: 590 SLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQAKME-SLVVS 648
SL ++ Y VR+ A T+ G G S + +T Q VP P L+ +A+ E S+ +S
Sbjct: 490 SLLEDETYTVRVLAFTSVGDGPLSDPIQVKT-----QQGVPGQPMNLRAEARSETSITLS 544
Query: 649 WQPPPHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLV 708
W PP + I Y+L +RE GD +VG R Y + L
Sbjct: 545 WSPPRQESIIK-YELLFRE----------------GDHGREVG--RTFDPTTSYVVEDLK 585
Query: 709 PGRLYEVKLVAFNKHEDG-YAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIW 767
P Y +L A + G + V + +T +Q P PP V S ST+I
Sbjct: 586 PNTEYAFRLAARSPQGLGAFTPVVRQRT---------LQSKPSAPPQDVKCVSVRSTAIL 636
Query: 768 LRWKKPDFTTVK--IVNYTVRFSPWGLRN--ASLVTYYTSSGEDILIGGLKPFTKYEFAV 823
+ W+ P T +V Y+VR+ P G + V + IL+ L+ +T+Y
Sbjct: 637 VSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITT 696
Query: 824 QSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRLSPLTPSTVRLHWCPPT--EPNGEI--- 878
+H GP S V T D PS PP + L + +R+ W P +G+I
Sbjct: 697 VAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGY 756
Query: 879 -VEYLILYSSNHTQP---------EHQWTLLTTQGNIFSAEVHGLESDTRYFFKMGARTE 928
V Y+ + + P + QW T + + L+ +T Y + A T
Sbjct: 757 QVHYVRMEGAEARGPPRIKDVMLADAQWE--TDDTAEYEMVITNLQPETAYSITVAAYTM 814
Query: 929 VGPGPFSRLQDVIT 942
G G S+ + V+T
Sbjct: 815 KGDGARSKPKVVVT 828
Score = 171 bits (433), Expect = 4e-42
Identities = 221/928 (23%), Positives = 365/928 (39%), Gaps = 126/928 (13%)
Query: 62 AAAGPPTRVTWSKDGDTL-------LEHDHLHLLPNGSLWLSQPLAPNGSDESVPEAVGV 114
A P RVTW+K G + +E D G++ QPL DE+V
Sbjct: 56 ATGDPKPRVTWNKKGKKVNSQRFETIEFDE----SAGAVLRIQPLR-TPRDENV------ 104
Query: 115 IEGNYSCLAHGPLGVLASQTAVVKL------ATLADFSLHPESQTVEENGTARFECHIEG 168
Y C+A +G + + L + + + P+ + VE TA C G
Sbjct: 105 ----YECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASG 160
Query: 169 LPAPIITWEKDQVTLPEEP-----RLIVLPN---------GVLQILDVQESDAGPYRCVA 214
P P ITW KD LP +P R+ L + G LQI +E+D G Y CVA
Sbjct: 161 NPDPEITWFKD--FLPVDPSASNGRIKQLRSETFESTPIRGALQIESSEETDQGKYECVA 218
Query: 215 TNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPF 274
TNSA +S A L V L R P + ++ G +V + CVA P P+
Sbjct: 219 TNSAGVRYSSPANLYVR---ELREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPY 275
Query: 275 VSWVRQDGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLAA 334
V W++ D + +GR L + + + S Y C A + A A++ V +
Sbjct: 276 VKWMQGAEDLTPEDDMPVGRNVLELTDVK--DSANYTCVAMS--SLGVIEAVAQITVKSL 331
Query: 335 PAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQ 394
P P T +T+ + SG P P ++ +G +++ + +
Sbjct: 332 PKAPGTPMVTENT--ATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSI 389
Query: 395 IGLQDAGYYQ--CVAENSAGMACAAASLAVVVREGLP-SAPTRVTATPLSSSAVLVAWER 451
GL Y+ A NS G + S+ E P SAP V A LS++ ++V WE
Sbjct: 390 GGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEE 449
Query: 452 PEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGA 511
P + I G+ ++Y +Q +D+ V L + Y V+A++ +G
Sbjct: 450 PVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGD 509
Query: 512 SRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKE 571
S P V T VP L + + + I ++W P P S ++KY++ + G
Sbjct: 510 GPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSP-PRQES---IIKYELLFREGDH 565
Query: 572 DQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPF 631
+ T ++ L+PN Y R++A + G GA + + RT QS
Sbjct: 566 GREVG-RTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRT----LQSKPSA 620
Query: 632 APAELK-VQAKMESLVVSWQPPP---HPTQISGYKLYWREVGAEE----EANGDRLPGGR 683
P ++K V + +++VSW+PPP H + GY + +R +G+E+ E NG
Sbjct: 621 PPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNG------- 673
Query: 684 GDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDM 743
+ Q L L Y + VA + G E +P
Sbjct: 674 -----------IPPTTTQILLEALEKWTQYRITTVAHTEVGPG--------PESSPVVVR 714
Query: 744 PIQRGPPLPPAHVHAESNSSTSIWLRWKK--PDFTTVKIVNYTVRF---------SPWGL 792
+ P PP V AE+ ++T+I + W+ P +I Y V + P +
Sbjct: 715 TDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRI 774
Query: 793 RNASLVTYYTSSGE----DILIGGLKPFTKYEFAVQSHGVDMDGPFGS---VVERSTLPD 845
++ L + + +++I L+P T Y V ++ + DG VV + +
Sbjct: 775 KDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLG 834
Query: 846 RPSTPPSDLRLSPLTPSTVRLHWCPPT-EPNGEIVEYLILYSSNHTQPEHQWTLLTTQGN 904
RP+ L + ++ W PP +++ Y + + + P ++
Sbjct: 835 RPT-----LSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDR 889
Query: 905 IFSAEVHGLESDTRYFFKMGARTEVGPG 932
++ VH Y F++ AR+ G G
Sbjct: 890 YTASGVH---KGATYVFRLAARSRGGLG 914
Score = 165 bits (417), Expect = 3e-40
Identities = 241/943 (25%), Positives = 367/943 (38%), Gaps = 106/943 (11%)
Query: 40 VGPLQVILGPEQAAVLNCSLGAAAAGPPTRVTWSKDG---DTLLEHDHLHLLPNGSLWLS 96
+GP ++ + A + C AA+ P +TW KD D + + L + S
Sbjct: 139 MGPQLKVVERTRTATMLC---AASGNPDPEITWFKDFLPVDPSASNGRIKQL-RSETFES 194
Query: 97 QPLAPNGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLAD-------FSLHP 149
P+ ES E +G Y C+A GV S A + + L + FS+ P
Sbjct: 195 TPIRGALQIESSEETD---QGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILP 251
Query: 150 ESQTVEENGTARFECHIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGP 209
S + G C G P P + W + L E + V N VL++ DV+ D+
Sbjct: 252 MSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRN-VLELTDVK--DSAN 308
Query: 210 YRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASA 269
Y CVA +S EA+ + + SL G +V + T+ S
Sbjct: 309 YTCVAMSSLGVI---EAVAQITVK-SLPKAPGTPMVTENTATSITITWD---------SG 355
Query: 270 DPTPFVSWV------RQDGK-PISTDVIVLGRTNLLIANAQP------WHSGVYVCRANK 316
+P P +V QDG I D+ T I P W S V
Sbjct: 356 NPDPVSYYVIEYKSKSQDGPYQIKEDITT---TRYSIGGLSPNSEYEIWVSAVNSIGQGP 412
Query: 317 PRTRDFATAAAELRVLAAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLR 376
P + T E +AP QA + T +G R R + P
Sbjct: 413 P-SESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIR-GYRVYYTMEPEH 470
Query: 377 PNGRVKVQGGGGSLVITQIG--LQDAGY-YQCVAENSAGMACAAASLAVVVREGLPSAPT 433
P G + SL +T +G L+D Y + +A S G + + V ++G+P P
Sbjct: 471 PVGNWQKHNVDDSL-LTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPM 529
Query: 434 RVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDL 493
+ A S +++ ++W P E II + L +++ V F + TT V DL
Sbjct: 530 NLRAEARSETSITLSWSPPRQ--ESIIKYELLFREGDHGREVGRTF---DPTTSYVVEDL 584
Query: 494 EPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQ-LSLSSPNPSDIRVAWLPLPP 552
+PNT+Y F + A S G + TL PSA PQ + S + I V+W P PP
Sbjct: 585 KPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPP 644
Query: 553 SLSNGQVVKYKIEYG-LGKEDQIFSTEVRG---NETQLMLNSLQPNKVYRVRISAGTAAG 608
NG +V Y + Y LG ED EV G TQ++L +L+ YR+ A T G
Sbjct: 645 ETHNGALVGYSVRYRPLGSEDPE-PKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVG 703
Query: 609 FGAPSQWMHHRTPSMHNQSHVPFAPAELKVQAKM---ESLVVSWQPPP---HPTQISGYK 662
G S + RT VP AP KV+A+ ++ V W+ P QI GY+
Sbjct: 704 PGPESSPVVVRT-----DEDVPSAPPR-KVEAEALNATAIRVLWRSPAPGRQHGQIRGYQ 757
Query: 663 LYWREVGAEEEANGDRLPGGR-GDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFN 721
+++ + E R+ D W+ + V +T L P Y + + A+
Sbjct: 758 VHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMV----ITNLQPETAYSITVAAYT 813
Query: 722 KHEDGYAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTV-KI 780
DG + P + + +G L + + S+ RW+ P T ++
Sbjct: 814 MKGDGARS----------KPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQV 863
Query: 781 VNYTVRFSPWGLRNASLVTYYTSSGEDILIGGLKPFTK-YEFAVQSHGVDMDGPFGSVVE 839
+ Y ++F + + + S G K T + A +S G G E
Sbjct: 864 LGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRG----GLGEEAAE 919
Query: 840 RSTLP-DRPSTPPSDLRLSP-LTPSTVRLHWCPPT--EPNGEIVEYLI-LYSSNHTQPEH 894
++P D P P L + + TV L W PP E NG IV+Y + + + P
Sbjct: 920 VLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPAR 979
Query: 895 QWTL--LTTQGNIFSAEVHGLESDTRYFFKMGARTEVGPGPFS 935
+ L G + + GL+ DT Y ++ A T GPGPFS
Sbjct: 980 ETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFS 1022
Score = 118 bits (295), Expect = 4e-26
Identities = 127/512 (24%), Positives = 211/512 (41%), Gaps = 60/512 (11%)
Query: 403 YQCVAENSAGMACAAASLAVVVREGLPSAPTR-VTATPLSSSAVLVAWERP--EMHSEQI 459
++ A + G+ + + PSAP + V + S+A+LV+W P E H+ +
Sbjct: 592 FRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGAL 651
Query: 460 IGFSLHYQKARGMDNVEYQF-AVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPA 518
+G+S+ Y+ D + + TT++ + LE T Y VA++++G S+P
Sbjct: 652 VGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPV 711
Query: 519 LVHTLDDVPSAAP-QLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEY---------GL 568
+V T +DVPSA P ++ + N + IRV W P +GQ+ Y++ Y G
Sbjct: 712 VVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGP 771
Query: 569 GKEDQIFSTEVRGN-----ETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSM 623
+ + + + E ++++ +LQP Y + ++A T G GA S+ P +
Sbjct: 772 PRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSK------PKV 825
Query: 624 HNQSHVPFAPAELKVQAKME-SLVVSWQPPPHPTQISGYKLYWREVGAEEEANGDRLPGG 682
L VQ E SL+ W+PP AE++ G RL G
Sbjct: 826 VVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGT--------------AEDQVLGYRLQFG 871
Query: 683 RGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPD 742
R D + + +Y + + G Y +L A ++ G E A
Sbjct: 872 REDST-PLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLG--------EEAAEVLS 922
Query: 743 MPIQRGPPLPPAHVHAESNSST-SIWLRW--KKPDFTTVKIVNYTVRFSPWGLRNASLVT 799
+P + P P + A N+S ++ LRW P IV YTV G + T
Sbjct: 923 IP-EDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARET 981
Query: 800 YYTSSGED-----ILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDL 854
++ E + + GLKP T Y+ V++H GPF V T R P +
Sbjct: 982 ELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFL-RDQVSPKNF 1040
Query: 855 RLSPLTPSTVRLHWCPPTEPNGEIVEYLILYS 886
++ + ++V L W P N Y I Y+
Sbjct: 1041 KVKMIMKTSVLLSWEFPDNYNSP-TPYKIQYN 1071
Score = 88.6 bits (218), Expect = 3e-17
Identities = 109/454 (24%), Positives = 175/454 (38%), Gaps = 69/454 (15%)
Query: 406 VAENSAGMACAAASLAVVVREGLPSAPTR-VTATPLSSSAVLVAWERPEMHSE--QIIGF 462
VA G ++ + V E +PSAP R V A L+++A+ V W P + QI G+
Sbjct: 697 VAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGY 756
Query: 463 SLHYQK-----ARGMDNVEYQFAVN-----NDTTELQ--VRDLEPNTDYEFYVVAYSQLG 510
+HY + ARG ++ + +DT E + + +L+P T Y V AY+ G
Sbjct: 757 QVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKG 816
Query: 511 ASRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGK 570
S P +V T V P LS+ + W P P + QV+ Y++++G
Sbjct: 817 DGARSKPKVVVTKGAV-LGRPTLSVQQTPEGSLLARWEP-PAGTAEDQVLGYRLQFGRED 874
Query: 571 EDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFG---APSQWMHHRTPSMHNQS 627
+ + E +E + + + Y R++A + G G A + TP H Q
Sbjct: 875 STPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQI 934
Query: 628 HVPFAPAELKVQAKMESLVVSWQPPPHPTQISG----YKLYWREVGAEEEANGDRLPGGR 683
E A ++++ W PP P + +G Y + RE GA A LP
Sbjct: 935 ------LEAAGNASAGTVLLRWLPPV-PAERNGAIVKYTVAVREAGALGPARETELPAAA 987
Query: 684 GDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDM 743
A + L L P Y++++ + T + P P
Sbjct: 988 EPGAENA-----------LTLQGLKPDTAYDLQV--------------RAHTRRGPGPFS 1022
Query: 744 PIQR-----GPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRFSPWGLRNASLV 798
P R + P + + TS+ L W+ PD NY +P+ ++ L
Sbjct: 1023 PPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPD-------NYNSP-TPYKIQYNGLT 1074
Query: 799 TYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDG 832
LI LKP T Y F + + G + G
Sbjct: 1075 LDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGG 1108
Score = 82.8 bits (203), Expect = 2e-15
Identities = 140/647 (21%), Positives = 249/647 (38%), Gaps = 93/647 (14%)
Query: 335 PAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQ---GGGGSLV 391
P + P+ A FVC+A+G+P+P + W G + ++ G L
Sbjct: 33 PRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLR 92
Query: 392 ITQIGL-QDAGYYQCVAENSAGMACAAASLAVVVREGLPSAPTRVTATPL--------SS 442
I + +D Y+CVA+NS G A L V+ + LPS + P ++
Sbjct: 93 IQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTA 152
Query: 443 SAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTE----LQVRDLEPNTD 498
+ + A P+ F L + ++ + ++T LQ+ E
Sbjct: 153 TMLCAASGNPDPEITWFKDF-LPVDPSASNGRIKQLRSETFESTPIRGALQIESSEETDQ 211
Query: 499 YEFYVVAYSQLGASRTSTPA--LVHTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSN 556
++ VA + G R S+PA V L +V AP+ S+ P +I ++
Sbjct: 212 GKYECVATNSAGV-RYSSPANLYVRELREVRRVAPRFSIL-PMSHEIMPGGNVNITCVAV 269
Query: 557 GQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWM 616
G + Y +++ G ED ++ L L ++ + Y ++ + A +Q
Sbjct: 270 GSPMPY-VKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTC-VAMSSLGVIEAVAQIT 327
Query: 617 HHRTPSMHNQSHVPFAPAELKVQAKMESLVVSWQPPPHPTQISGYKLYWREVGAEEEANG 676
P P P + + S+ ++W +P +S Y + ++ +
Sbjct: 328 VKSLPK------APGTP--MVTENTATSITITWDSG-NPDPVSYYVIEYKSKSQD----- 373
Query: 677 DRLPGGRGDQAWDVGPVRLKKKVK--QYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGK 734
GP ++K+ + +Y + L P YE+ + A N G
Sbjct: 374 --------------GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQG-------- 411
Query: 735 TEKAPAPDMPIQRGPPLP---PAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRFSP-- 789
P+ + + G P P +V A S+T++ ++W++P I Y V ++
Sbjct: 412 ---PPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEP 468
Query: 790 ------WGLRNA--SLVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERS 841
W N SL+T S ED + +T A S G DGP ++
Sbjct: 469 EHPVGNWQKHNVDDSLLTTVGSLLED------ETYTVRVLAFTSVG---DGPLSDPIQVK 519
Query: 842 TLPDRPSTPPSDLRLSPLTPSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTT 901
T P P +LR + +++ L W PP + + I++Y +L+ +H + T
Sbjct: 520 TQQGVPGQP-MNLRAEARSETSITLSWSPPRQES--IIKYELLFREG----DHGREVGRT 572
Query: 902 QGNIFSAEVHGLESDTRYFFKMGARTEVGPGPFSRLQDVITLQEKLS 948
S V L+ +T Y F++ AR+ G G F+ + TLQ K S
Sbjct: 573 FDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPS 619
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform
1 precursor [Homo sapiens]
Length = 1907
Score = 189 bits (480), Expect = 1e-47
Identities = 226/875 (25%), Positives = 346/875 (39%), Gaps = 99/875 (11%)
Query: 149 PESQTVEENGTARFECHIEGLPAPIITW-EKDQVTLPEEPRLIVLPNGVLQILDVQ---- 203
PE QT G A F C G P P ITW +K + + +I +G +L +Q
Sbjct: 39 PEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRV 98
Query: 204 ESDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVM 263
+ D Y C ATNS + + A LSV L I P+ V ++ M
Sbjct: 99 QRDEAIYECTATNSLGE-INTSAKLSVLEEEQLPPGFPS---IDMGPQLKVVEKARTATM 154
Query: 264 ECVASADPTPFVSWVRQ----DGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRA-NKPR 318
C A +P P +SW + D + + L L I +++ G Y C A N
Sbjct: 155 LCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAG 214
Query: 319 TRDFATAAAELRVL-AAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRP 377
TR A A +RV AP + P + + C A G P P ++W+ L
Sbjct: 215 TRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTK 274
Query: 378 NGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAVVVREGLPSAPTRVTA 437
+ V G V+ + + Y CVA +S GM A A + V + LP P +
Sbjct: 275 EDEMPV----GRNVLELSNVVRSANYTCVAISSLGMIEATAQVTV---KALPKPPIDLVV 327
Query: 438 TPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNT 497
T ++++V + W+ +SE + + + Y +A G + +Q TT + L P +
Sbjct: 328 TETTATSVTLTWDSG--NSEPVTYYGIQY-RAAGTEG-PFQEVDGVATTRYSIGGLSPFS 383
Query: 498 DYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQ-LSLSSPNPSDIRVAWLPLPPSLSN 556
+Y F V+A + +G S T + PS+ P+ + + S + V W P P N
Sbjct: 384 EYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEP--PEEPN 441
Query: 557 GQVVKYKIEYGLGKEDQIFSTEVRGNETQLM--LNSLQPNKVYRVRISAGTAAGFGAPSQ 614
G V Y++ Y + + L+ + SL P Y +R+ A TA G G PS
Sbjct: 442 GLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSP 501
Query: 615 WMHHRTPSMHNQSHVPFAPAELKVQAKMESLV-VSWQPPPHPTQISGYKLYWREVGAEEE 673
+ +T Q VP PA+ + + + ++ + +SW PP I +YW AE+E
Sbjct: 502 TIQVKT-----QQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYW---AAEDE 553
Query: 674 ANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKG 733
DQ V Y L L P LY +L A D V+
Sbjct: 554 -----------DQQHKV----TFDPTSSYTLEDLKPDTLYRFQLAA---RSDMGVGVFTP 595
Query: 734 KTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKP--DFTTVKIVNYTVRFSPWG 791
E A Q P PP V S ST++ + W P D I Y+V +
Sbjct: 596 TIEARTA-----QSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVD 650
Query: 792 L--RNASLVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPST 849
R +V + + GL+ +T+Y V++H GP S V T D PS
Sbjct: 651 GEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSG 710
Query: 850 PPSDLRLSPLTPSTVRLHW--CPPTEPNGEIVEYLILY-SSNHTQP------------EH 894
PP + + PL + V ++W P++ +G+I Y + Y + +P E
Sbjct: 711 PPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEA 770
Query: 895 QWTLLTTQGNIFSAEVHGLESDTRYFFKMGARTEVGPGPFSRLQDVITLQEKLSDSLDMH 954
QW + + + GL +T Y + A T G G S+ + V T
Sbjct: 771 QWR--PEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTT------------ 816
Query: 955 SVTGIIVGVCLGLLCLLACMCAGLRRSPHRESLPG 989
TG + G ++ A A L+ P +E LPG
Sbjct: 817 --TGAVPGRPTMMISTTAMNTALLQWHPPKE-LPG 848
Score = 178 bits (452), Expect = 3e-44
Identities = 233/921 (25%), Positives = 360/921 (39%), Gaps = 125/921 (13%)
Query: 62 AAAGPPTRVTWSKDGDTL-------LEHDHLHLLPNGSLWLSQPLAPNGSDESVPEAVGV 114
A P R+TW K G + +E D GS+ QPL DE++
Sbjct: 56 ATGEPKPRITWMKKGKKVSSQRFEVIEFDD----GAGSVLRIQPLRVQ-RDEAI------ 104
Query: 115 IEGNYSCLAHGPLGVLASQTAVVKLATLAD---------FSLHPESQTVEENGTARFECH 165
Y C A LG + + KL+ L + + P+ + VE+ TA C
Sbjct: 105 ----YECTATNSLGEINTSA---KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCA 157
Query: 166 IEGLPAPIITWEKDQVTLPEEP-----RLIVLPNGVLQILDVQESDAGPYRCVATNSARQ 220
G P P I+W KD LP +P R+ L +G LQI +ESD G Y CVATNSA
Sbjct: 158 AGGNPDPEISWFKD--FLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGT 215
Query: 221 HFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQ 280
+S A L V R P + V+ G SV + CVA P P+V W+
Sbjct: 216 RYSAPANLYVRVRRVAPR-------FSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMG 268
Query: 281 DGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQA 340
+ D + +GR L ++N S Y C A ATA ++ L P I
Sbjct: 269 AEELTKEDEMPVGRNVLELSNVV--RSANYTCVAISSLGMIEATAQVTVKALPKPPI--- 323
Query: 341 PEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDA 400
+ + +T+ + SG P + G + G + + GL
Sbjct: 324 -DLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPF 382
Query: 401 GYY--QCVAENSAGMACAAASLAVVVREGLPSA-PTRVTATPLSSSAVLVAWERPEMHSE 457
Y + +A NS G + ++ E PS+ P RV A LS+S +LV WE PE +
Sbjct: 383 SEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNG 442
Query: 458 QIIGFSLHY-QKARGMDNVEYQFAVNNDTTEL-QVRDLEPNTDYEFYVVAYSQLGASRTS 515
+ G+ ++Y +R N ++ N D L V L P Y V+A++ +G S
Sbjct: 443 LVRGYRVYYTPDSRRPPNAWHKH--NTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPS 500
Query: 516 TPALVHTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKEDQIF 575
V T VP+ + + I+++WL LPP +++ Y++ Y +++
Sbjct: 501 PTIQVKTQQGVPAQPADFQAEVESDTRIQLSWL-LPP---QERIIMYELVYWAAEDEDQQ 556
Query: 576 STEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAE 635
+ L L+P+ +YR +++A + G G + + RT P AP +
Sbjct: 557 HKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEART-----AQSTPSAPPQ 611
Query: 636 LKVQAKMESLV--VSWQPPPHPTQ---ISGYKLYWREVGAEEEANGDRLPGGRGDQAWDV 690
+ M S VSW PPP ++ I+ Y + + V E+ RG D
Sbjct: 612 KVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGED----------RGRHVVD- 660
Query: 691 GPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQRGPP 750
+ ++ ++L L Y V + A G E +P + P
Sbjct: 661 ---GISREHSSWDLVGLEKWTEYRVWVRAHTDVGPG--------PESSPVLVRTDEDVPS 709
Query: 751 LPPAHVHAESNSSTSIWLRWKKP------------DFTTVKIVNYTVRFSPWGLRNASLV 798
PP V E +ST++ + WK P T V++ N R P +++ L
Sbjct: 710 GPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPI-IQDVMLA 768
Query: 799 TYY----TSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGS---VVERSTLPDRPSTPP 851
S + I GL P T Y V ++ DG V +P RP+
Sbjct: 769 EAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPT--- 825
Query: 852 SDLRLSPLTPSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVH 911
+ +S +T L W PP E GE++ Y + Y E + + + V
Sbjct: 826 --MMISTTAMNTALLQWHPPKELPGELLGYRLQYC---RADEARPNTIDFGKDDQHFTVT 880
Query: 912 GLESDTRYFFKMGARTEVGPG 932
GL T Y F++ A+ G G
Sbjct: 881 GLHKGTTYIFRLAAKNRAGLG 901
Score = 169 bits (428), Expect = 2e-41
Identities = 192/743 (25%), Positives = 294/743 (39%), Gaps = 109/743 (14%)
Query: 234 GSLASTRGQDV-VIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPIST---DV 289
G +A G V + PE+ T +SG C A+ +P P ++W+++ GK +S+ +V
Sbjct: 22 GLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKK-GKKVSSQRFEV 80
Query: 290 IVLGRTNLLIANAQPWH----SGVYVCRANKPRTRDFATAAAELRVLAA-------PAIT 338
I + QP +Y C A +A+L VL P+I
Sbjct: 81 IEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGE--INTSAKLSVLEEEQLPPGFPSID 138
Query: 339 QAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRP---NGRVKVQGGGGSLVITQI 395
P+ +A TA +C A G P P + W + P+ P NGR+K Q G+L I
Sbjct: 139 MGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIK-QLRSGALQIESS 197
Query: 396 GLQDAGYYQCVAENSAGMACAA-ASLAVVVR-------------EGLPSAPTRVTATPLS 441
D G Y+CVA NSAG +A A+L V VR E +P +T +
Sbjct: 198 EESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVG 257
Query: 442 SSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEF 501
+ V W M +E++ E + V + EL N +
Sbjct: 258 APMPYVKWM---MGAEEL--------------TKEDEMPVGRNVLELSNVVRSAN----Y 296
Query: 502 YVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVK 561
VA S LG + V L P L ++ + + + W S ++ V
Sbjct: 297 TCVAISSLGMIEATAQVTVKAL---PKPPIDLVVTETTATSVTLTW----DSGNSEPVTY 349
Query: 562 YKIEYGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTP 621
Y I+Y + F T+ + L P Y R+ A + G G PS+ + RT
Sbjct: 350 YGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTG 409
Query: 622 SMHNQSHVPFAPAELKVQAKMES---LVVSWQPPPHPTQ-ISGYKLYWREVGAEEEANGD 677
P +P +VQA+M S ++V W+PP P + GY++Y+ +
Sbjct: 410 EQ-----APSSPPR-RVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTP-------DSR 456
Query: 678 RLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEK 737
R P D G + + L+PG Y ++++AF DG
Sbjct: 457 RPPNAWHKHNTDAGLLTT--------VGSLLPGITYSLRVLAFTAVGDG---------PP 499
Query: 738 APAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRFSPWGLRNASL 797
+P + Q+G P PA AE S T I L W P +I+ Y + + W +
Sbjct: 500 SPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPP--QERIIMYELVY--WAAEDEDQ 555
Query: 798 ---VTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDL 854
VT+ +S + LKP T Y F + + G F +E T PS PP +
Sbjct: 556 QHKVTFDPTSS--YTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKV 613
Query: 855 RLSPLTPSTVRLHWCPP--TEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHG 912
+ +TVR+ W PP NG I +Y + Y + + + + S ++ G
Sbjct: 614 MCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVG 673
Query: 913 LESDTRYFFKMGARTEVGPGPFS 935
LE T Y + A T+VGPGP S
Sbjct: 674 LEKWTEYRVWVRAHTDVGPGPES 696
Score = 136 bits (343), Expect = 1e-31
Identities = 220/933 (23%), Positives = 344/933 (36%), Gaps = 102/933 (10%)
Query: 37 SCGVGPLQVILGPEQAAVLNCSLGAAAAGPPTRVTWSKDG---DTLLEHDHLHLLPNGSL 93
S +GP ++ + A + C AA P ++W KD D + + L +G+L
Sbjct: 136 SIDMGPQLKVVEKARTATMLC---AAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGAL 192
Query: 94 WLSQPLAPNGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTA--VVKLATLAD-FSLHPE 150
+ S+ES +G Y C+A G S A V++ +A FS+ P
Sbjct: 193 QIES------SEESD-------QGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPS 239
Query: 151 SQTVEENGTARFECHIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPY 210
SQ V G+ C G P P + W L +E + V N VL++ +V S Y
Sbjct: 240 SQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRN-VLELSNVVRS--ANY 296
Query: 211 RCVATNS-----ARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMEC 265
CVA +S A + +AL + T V + N+ V+ +
Sbjct: 297 TCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRA 356
Query: 266 VASADPTPFVSWVRQDGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATA 325
+ P V V T I P+ + A R +
Sbjct: 357 AGTEGPFQEVDGV--------------ATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSE 402
Query: 326 AAELRV-LAAPAITQAPEALSRTRASTARFVCRASGEPRPALR----WLHNGAPLRPNGR 380
A R AP+ AST EP +R + + PN
Sbjct: 403 AVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAW 462
Query: 381 VKVQGGGGSLVITQIGLQDAGY-YQCVAENSAGMACAAASLAVVVREGLPSAPTRVTATP 439
K G L L Y + +A + G + ++ V ++G+P+ P A
Sbjct: 463 HKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEV 522
Query: 440 LSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNND-TTELQVRDLEPNTD 498
S + + ++W P E+II + L Y A D Q V D T+ + DL+P+T
Sbjct: 523 ESDTRIQLSWLLPPQ--ERIIMYELVYWAAEDEDQ---QHKVTFDPTSSYTLEDLKPDTL 577
Query: 499 YEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLS-SPNPSDIRVAWLPLPPSLSNG 557
Y F + A S +G + T PSA PQ + S + +RV+W+P P NG
Sbjct: 578 YRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNG 637
Query: 558 QVVKYKIEYGLGKEDQIFSTEVRG---NETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQ 614
+ +Y + Y + V G + L L+ YRV + A T G G S
Sbjct: 638 VITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESS 697
Query: 615 WMHHRTPSMHNQSHVPFAPA-ELKVQAKMESLV-VSWQ---PPPHPTQISGYKL-YWREV 668
+ RT VP P +++V+ + V V W+ P QI GY++ Y R
Sbjct: 698 PVLVRT-----DEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLE 752
Query: 669 GAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELT--QLVPGRLYEVKLVAFNKHEDG 726
E + W ++ + YE T L P Y V + A+ DG
Sbjct: 753 NGEPRGLPIIQDVMLAEAQWR------PEESEDYETTISGLTPETTYSVTVAAYTTKGDG 806
Query: 727 YAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVR 786
+ K T P P + + + L+W P +++ Y ++
Sbjct: 807 ARSKPKIVTTTGAVPGRPTMM----------ISTTAMNTALLQWHPPKELPGELLGYRLQ 856
Query: 787 FSPWGLRNASLVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERS--TLP 844
+ + + + + + GL T Y F + + G E+ T
Sbjct: 857 YCRADEARPNTIDF-GKDDQHFTVTGLHKGTTYIFRLAAKN---RAGLGEEFEKEIRTPE 912
Query: 845 DRPSTPPSDLRLSPLTPSTVRLHWCPP--TEPNGEIVEYLILYSSNHTQPEHQWTLLTTQ 902
D PS P +L ++ LT ST L W PP E NG I+ Y +++ ++Q E Q T+
Sbjct: 913 DLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTR 972
Query: 903 GNIFSAEVHGLESDTRYFFKMGARTEVGPGPFS 935
+ GL+ DT Y K+ A T G GP S
Sbjct: 973 FTL-----TGLKPDTTYDIKVRAWTSKGSGPLS 1000
Score = 112 bits (281), Expect = 2e-24
Identities = 130/568 (22%), Positives = 231/568 (40%), Gaps = 79/568 (13%)
Query: 403 YQCVAENSAGMACAAASLAVVVREGLPSAPT-RVTATPLSSSAVLVAWERPEMHSEQ--I 459
+Q A + G+ ++ + PSAP +V + S+ V V+W P S I
Sbjct: 580 FQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVI 639
Query: 460 IGFSLHYQKARGMDNVEYQF-AVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPA 518
+S+ Y+ G D + ++ + + + LE T+Y +V A++ +G S+P
Sbjct: 640 TQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPV 699
Query: 519 LVHTLDDVPSAAPQLSLSSP-NPSDIRVAWLPLPPSLSNGQVVKYKIEY---------GL 568
LV T +DVPS P+ P N + + V W PS +GQ+ Y++ Y GL
Sbjct: 700 LVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGL 759
Query: 569 GKEDQIFSTEVR-----GNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSM 623
+ E + + + ++ L P Y V ++A T G GA S + +
Sbjct: 760 PIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARS-----KPKIV 814
Query: 624 HNQSHVPFAPAELKVQAKMESLVVSWQPPPH-PTQISGYKLYWREVGAEEEANGDRLPGG 682
VP P + M + ++ W PP P ++ GY+L + +EA + + G
Sbjct: 815 TTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRA---DEARPNTIDFG 871
Query: 683 RGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPD 742
+ DQ + +T L G Y +L A N+ G + +T + D
Sbjct: 872 KDDQ--------------HFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPE----D 913
Query: 743 MPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFT--TVKIVNYTVRF----SPWGLRNAS 796
+P P ++H ++++ L W P +I++YTV F S L+N +
Sbjct: 914 LPSGF-----PQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNIT 968
Query: 797 LVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRL 856
T +T + GLKP T Y+ V++ GP ++ T+P + R+
Sbjct: 969 TDTRFT-------LTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVE-QVFAKNFRV 1020
Query: 857 SPLTPSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESD 916
+ ++V L W P + V + ILY+ + G+ + L+ +
Sbjct: 1021 AAAMKTSVLLSWEVP-DSYKSAVPFKILYNGQSVE---------VDGHSMRKLIADLQPN 1070
Query: 917 TRYFFKMGARTEVGPGPFSRLQDVITLQ 944
T Y F + R G LQ +++++
Sbjct: 1071 TEYSFVLMNRGSSAGG----LQHLVSIR 1094
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform
2 precursor [Homo sapiens]
Length = 1898
Score = 187 bits (475), Expect = 5e-47
Identities = 224/867 (25%), Positives = 344/867 (39%), Gaps = 92/867 (10%)
Query: 149 PESQTVEENGTARFECHIEGLPAPIITW-EKDQVTLPEEPRLIVLPNGVLQILDVQ---- 203
PE QT G A F C G P P ITW +K + + +I +G +L +Q
Sbjct: 39 PEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRV 98
Query: 204 ESDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVM 263
+ D Y C ATNS + + A LSV L I P+ V ++ M
Sbjct: 99 QRDEAIYECTATNSLGE-INTSAKLSVLEEEQLPPGFPS---IDMGPQLKVVEKARTATM 154
Query: 264 ECVASADPTPFVSWVRQ----DGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRA-NKPR 318
C A +P P +SW + D + + L L I +++ G Y C A N
Sbjct: 155 LCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAG 214
Query: 319 TRDFATAAAELRVL-AAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRP 377
TR A A +RV AP + P + + C A G P P ++W+ L
Sbjct: 215 TRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTK 274
Query: 378 NGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAVVVREGLPSAPTRVTA 437
+ V G V+ + + Y CVA +S GM A A + V + LP P +
Sbjct: 275 EDEMPV----GRNVLELSNVVRSANYTCVAISSLGMIEATAQVTV---KALPKPPIDLVV 327
Query: 438 TPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNT 497
T ++++V + W+ +SE + + + Y +A G + +Q TT + L P +
Sbjct: 328 TETTATSVTLTWDSG--NSEPVTYYGIQY-RAAGTEG-PFQEVDGVATTRYSIGGLSPFS 383
Query: 498 DYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQ-LSLSSPNPSDIRVAWLPLPPSLSN 556
+Y F V+A + +G S T + PS+ P+ + + S + V W P P N
Sbjct: 384 EYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEP--PEEPN 441
Query: 557 GQVVKYKIEYGLGKEDQIFSTEVRGNETQLM--LNSLQPNKVYRVRISAGTAAGFGAPSQ 614
G V Y++ Y + + L+ + SL P Y +R+ A TA G G PS
Sbjct: 442 GLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSP 501
Query: 615 WMHHRTPSMHNQSHVPFAPAELKVQAKMESLV-VSWQPPPHPTQISGYKLYWREVGAEEE 673
+ +T Q VP PA+ + + + ++ + +SW PP I +YW AE+E
Sbjct: 502 TIQVKT-----QQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYW---AAEDE 553
Query: 674 ANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKG 733
DQ V Y L L P LY +L A D V+
Sbjct: 554 -----------DQQHKV----TFDPTSSYTLEDLKPDTLYRFQLAA---RSDMGVGVFTP 595
Query: 734 KTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKP--DFTTVKIVNYTVRFSPWG 791
E A Q P PP V S ST++ + W P D I Y+V +
Sbjct: 596 TIEARTA-----QSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVD 650
Query: 792 L--RNASLVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPST 849
R +V + + GL+ +T+Y V++H GP S V T D PS
Sbjct: 651 GEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSG 710
Query: 850 PPSDLRLSPLTPSTVRLHW--CPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFS 907
PP + + PL + V ++W P++ +G+I Y + Y ++ ++
Sbjct: 711 PPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQ---DVML 767
Query: 908 AE-----VHGLESDTRYFFKMGARTEVGPGPFSRLQDVITLQEKLSDSLDMHSVTGIIVG 962
AE + GL +T Y + A T G G S+ + V T TG + G
Sbjct: 768 AEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTT--------------TGAVPG 813
Query: 963 VCLGLLCLLACMCAGLRRSPHRESLPG 989
++ A A L+ P +E LPG
Sbjct: 814 RPTMMISTTAMNTALLQWHPPKE-LPG 839
Score = 181 bits (459), Expect = 4e-45
Identities = 232/913 (25%), Positives = 359/913 (39%), Gaps = 118/913 (12%)
Query: 62 AAAGPPTRVTWSKDGDTL-------LEHDHLHLLPNGSLWLSQPLAPNGSDESVPEAVGV 114
A P R+TW K G + +E D GS+ QPL DE++
Sbjct: 56 ATGEPKPRITWMKKGKKVSSQRFEVIEFDD----GAGSVLRIQPLRVQ-RDEAI------ 104
Query: 115 IEGNYSCLAHGPLGVLASQTAVVKLATLAD---------FSLHPESQTVEENGTARFECH 165
Y C A LG + + KL+ L + + P+ + VE+ TA C
Sbjct: 105 ----YECTATNSLGEINTSA---KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCA 157
Query: 166 IEGLPAPIITWEKDQVTLPEEP-----RLIVLPNGVLQILDVQESDAGPYRCVATNSARQ 220
G P P I+W KD LP +P R+ L +G LQI +ESD G Y CVATNSA
Sbjct: 158 AGGNPDPEISWFKD--FLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGT 215
Query: 221 HFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQ 280
+S A L V R P + V+ G SV + CVA P P+V W+
Sbjct: 216 RYSAPANLYVRVRRVAPR-------FSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMG 268
Query: 281 DGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQA 340
+ D + +GR L ++N S Y C A ATA ++ L P I
Sbjct: 269 AEELTKEDEMPVGRNVLELSNVV--RSANYTCVAISSLGMIEATAQVTVKALPKPPI--- 323
Query: 341 PEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDA 400
+ + +T+ + SG P + G + G + + GL
Sbjct: 324 -DLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPF 382
Query: 401 GYY--QCVAENSAGMACAAASLAVVVREGLPSA-PTRVTATPLSSSAVLVAWERPEMHSE 457
Y + +A NS G + ++ E PS+ P RV A LS+S +LV WE PE +
Sbjct: 383 SEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNG 442
Query: 458 QIIGFSLHY-QKARGMDNVEYQFAVNNDTTEL-QVRDLEPNTDYEFYVVAYSQLGASRTS 515
+ G+ ++Y +R N ++ N D L V L P Y V+A++ +G S
Sbjct: 443 LVRGYRVYYTPDSRRPPNAWHKH--NTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPS 500
Query: 516 TPALVHTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKEDQIF 575
V T VP+ + + I+++WL LPP +++ Y++ Y +++
Sbjct: 501 PTIQVKTQQGVPAQPADFQAEVESDTRIQLSWL-LPP---QERIIMYELVYWAAEDEDQQ 556
Query: 576 STEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAE 635
+ L L+P+ +YR +++A + G G + + RT P AP +
Sbjct: 557 HKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEART-----AQSTPSAPPQ 611
Query: 636 LKVQAKMESLV--VSWQPPPHPTQ---ISGYKLYWREVGAEEEANGDRLPGGRGDQAWDV 690
+ M S VSW PPP ++ I+ Y + + V E+ RG D
Sbjct: 612 KVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGED----------RGRHVVD- 660
Query: 691 GPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQRGPP 750
+ ++ ++L L Y V + A G E +P + P
Sbjct: 661 ---GISREHSSWDLVGLEKWTEYRVWVRAHTDVGPG--------PESSPVLVRTDEDVPS 709
Query: 751 LPPAHVHAESNSSTSIWLRWK--KPDFTTVKIVNYTVRF------SPWGLRNASLVTYYT 802
PP V E +ST++ + WK P +I Y V + P GL +
Sbjct: 710 GPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGL--PIIQDVML 767
Query: 803 SSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGS---VVERSTLPDRPSTPPSDLRLSPL 859
+ ++ I GL P T Y V ++ DG V +P RP+ + +S
Sbjct: 768 AEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPT-----MMISTT 822
Query: 860 TPSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESDTRY 919
+T L W PP E GE++ Y + Y E + + + V GL T Y
Sbjct: 823 AMNTALLQWHPPKELPGELLGYRLQYC---RADEARPNTIDFGKDDQHFTVTGLHKGTTY 879
Query: 920 FFKMGARTEVGPG 932
F++ A+ G G
Sbjct: 880 IFRLAAKNRAGLG 892
Score = 169 bits (428), Expect = 2e-41
Identities = 192/743 (25%), Positives = 294/743 (39%), Gaps = 109/743 (14%)
Query: 234 GSLASTRGQDV-VIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPIST---DV 289
G +A G V + PE+ T +SG C A+ +P P ++W+++ GK +S+ +V
Sbjct: 22 GLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKK-GKKVSSQRFEV 80
Query: 290 IVLGRTNLLIANAQPWH----SGVYVCRANKPRTRDFATAAAELRVLAA-------PAIT 338
I + QP +Y C A +A+L VL P+I
Sbjct: 81 IEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGE--INTSAKLSVLEEEQLPPGFPSID 138
Query: 339 QAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRP---NGRVKVQGGGGSLVITQI 395
P+ +A TA +C A G P P + W + P+ P NGR+K Q G+L I
Sbjct: 139 MGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIK-QLRSGALQIESS 197
Query: 396 GLQDAGYYQCVAENSAGMACAA-ASLAVVVR-------------EGLPSAPTRVTATPLS 441
D G Y+CVA NSAG +A A+L V VR E +P +T +
Sbjct: 198 EESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVG 257
Query: 442 SSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEF 501
+ V W M +E++ E + V + EL N +
Sbjct: 258 APMPYVKWM---MGAEEL--------------TKEDEMPVGRNVLELSNVVRSAN----Y 296
Query: 502 YVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVK 561
VA S LG + V L P L ++ + + + W S ++ V
Sbjct: 297 TCVAISSLGMIEATAQVTVKAL---PKPPIDLVVTETTATSVTLTW----DSGNSEPVTY 349
Query: 562 YKIEYGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTP 621
Y I+Y + F T+ + L P Y R+ A + G G PS+ + RT
Sbjct: 350 YGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTG 409
Query: 622 SMHNQSHVPFAPAELKVQAKMES---LVVSWQPPPHPTQ-ISGYKLYWREVGAEEEANGD 677
P +P +VQA+M S ++V W+PP P + GY++Y+ +
Sbjct: 410 EQ-----APSSPPR-RVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTP-------DSR 456
Query: 678 RLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEK 737
R P D G + + L+PG Y ++++AF DG
Sbjct: 457 RPPNAWHKHNTDAGLLTT--------VGSLLPGITYSLRVLAFTAVGDG---------PP 499
Query: 738 APAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRFSPWGLRNASL 797
+P + Q+G P PA AE S T I L W P +I+ Y + + W +
Sbjct: 500 SPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPP--QERIIMYELVY--WAAEDEDQ 555
Query: 798 ---VTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDL 854
VT+ +S + LKP T Y F + + G F +E T PS PP +
Sbjct: 556 QHKVTFDPTSS--YTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKV 613
Query: 855 RLSPLTPSTVRLHWCPP--TEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHG 912
+ +TVR+ W PP NG I +Y + Y + + + + S ++ G
Sbjct: 614 MCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVG 673
Query: 913 LESDTRYFFKMGARTEVGPGPFS 935
LE T Y + A T+VGPGP S
Sbjct: 674 LEKWTEYRVWVRAHTDVGPGPES 696
Score = 138 bits (347), Expect = 4e-32
Identities = 218/930 (23%), Positives = 345/930 (37%), Gaps = 105/930 (11%)
Query: 37 SCGVGPLQVILGPEQAAVLNCSLGAAAAGPPTRVTWSKDG---DTLLEHDHLHLLPNGSL 93
S +GP ++ + A + C AA P ++W KD D + + L +G+L
Sbjct: 136 SIDMGPQLKVVEKARTATMLC---AAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGAL 192
Query: 94 WLSQPLAPNGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTA--VVKLATLAD-FSLHPE 150
+ S+ES +G Y C+A G S A V++ +A FS+ P
Sbjct: 193 QIES------SEESD-------QGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPS 239
Query: 151 SQTVEENGTARFECHIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPY 210
SQ V G+ C G P P + W L +E + V N VL++ +V S Y
Sbjct: 240 SQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRN-VLELSNVVRS--ANY 296
Query: 211 RCVATNS-----ARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMEC 265
CVA +S A + +AL + T V + N+ V+ +
Sbjct: 297 TCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRA 356
Query: 266 VASADPTPFVSWVRQDGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATA 325
+ P V V T I P+ + A R +
Sbjct: 357 AGTEGPFQEVDGV--------------ATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSE 402
Query: 326 AAELRV-LAAPAITQAPEALSRTRASTARFVCRASGEPRPALR----WLHNGAPLRPNGR 380
A R AP+ AST EP +R + + PN
Sbjct: 403 AVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAW 462
Query: 381 VKVQGGGGSLVITQIGLQDAGY-YQCVAENSAGMACAAASLAVVVREGLPSAPTRVTATP 439
K G L L Y + +A + G + ++ V ++G+P+ P A
Sbjct: 463 HKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEV 522
Query: 440 LSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNND-TTELQVRDLEPNTD 498
S + + ++W P E+II + L Y A D Q V D T+ + DL+P+T
Sbjct: 523 ESDTRIQLSWLLPPQ--ERIIMYELVYWAAEDEDQ---QHKVTFDPTSSYTLEDLKPDTL 577
Query: 499 YEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLS-SPNPSDIRVAWLPLPPSLSNG 557
Y F + A S +G + T PSA PQ + S + +RV+W+P P NG
Sbjct: 578 YRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNG 637
Query: 558 QVVKYKIEYGLGKEDQIFSTEVRG---NETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQ 614
+ +Y + Y + V G + L L+ YRV + A T G G S
Sbjct: 638 VITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESS 697
Query: 615 WMHHRTPSMHNQSHVPFAPA-ELKVQAKMESLV-VSWQ---PPPHPTQISGYKLYWREVG 669
+ RT VP P +++V+ + V V W+ P QI GY++ +
Sbjct: 698 PVLVRT-----DEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYV--- 749
Query: 670 AEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAA 729
RL G + V L + ++ ++ L P Y V + A+ DG +
Sbjct: 750 --------RLENGEPRGLPIIQDVMLAE-AQETTISGLTPETTYSVTVAAYTTKGDGARS 800
Query: 730 VWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRFSP 789
K T P P + + + L+W P +++ Y +++
Sbjct: 801 KPKIVTTTGAVPGRPTMM----------ISTTAMNTALLQWHPPKELPGELLGYRLQYCR 850
Query: 790 WGLRNASLVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERS--TLPDRP 847
+ + + + + GL T Y F + + G E+ T D P
Sbjct: 851 ADEARPNTIDF-GKDDQHFTVTGLHKGTTYIFRLAAKN---RAGLGEEFEKEIRTPEDLP 906
Query: 848 STPPSDLRLSPLTPSTVRLHWCPP--TEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNI 905
S P +L ++ LT ST L W PP E NG I+ Y +++ ++Q E Q T+ +
Sbjct: 907 SGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTL 966
Query: 906 FSAEVHGLESDTRYFFKMGARTEVGPGPFS 935
GL+ DT Y K+ A T G GP S
Sbjct: 967 -----TGLKPDTTYDIKVRAWTSKGSGPLS 991
Score = 114 bits (286), Expect = 4e-25
Identities = 129/559 (23%), Positives = 229/559 (40%), Gaps = 70/559 (12%)
Query: 403 YQCVAENSAGMACAAASLAVVVREGLPSAPT-RVTATPLSSSAVLVAWERPEMHSEQ--I 459
+Q A + G+ ++ + PSAP +V + S+ V V+W P S I
Sbjct: 580 FQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVI 639
Query: 460 IGFSLHYQKARGMDNVEYQF-AVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPA 518
+S+ Y+ G D + ++ + + + LE T+Y +V A++ +G S+P
Sbjct: 640 TQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPV 699
Query: 519 LVHTLDDVPSAAPQLSLSSP-NPSDIRVAWLPLPPSLSNGQVVKYKIEY-----GLGKED 572
LV T +DVPS P+ P N + + V W PS +GQ+ Y++ Y G +
Sbjct: 700 LVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGL 759
Query: 573 QIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFA 632
I + + ++ L P Y V ++A T G GA S + + VP
Sbjct: 760 PIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARS-----KPKIVTTTGAVPGR 814
Query: 633 PAELKVQAKMESLVVSWQPPPH-PTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVG 691
P + M + ++ W PP P ++ GY+L + +EA + + G+ DQ
Sbjct: 815 PTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRA---DEARPNTIDFGKDDQ----- 866
Query: 692 PVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQRGPPL 751
+ +T L G Y +L A N+ G + +T + D+P
Sbjct: 867 ---------HFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPE----DLPSGF---- 909
Query: 752 PPAHVHAESNSSTSIWLRWKKPDFT--TVKIVNYTVRF----SPWGLRNASLVTYYTSSG 805
P ++H ++++ L W P +I++YTV F S L+N + T +T
Sbjct: 910 -PQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFT--- 965
Query: 806 EDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRLSPLTPSTVR 865
+ GLKP T Y+ V++ GP ++ T+P + R++ ++V
Sbjct: 966 ----LTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVE-QVFAKNFRVAAAMKTSVL 1020
Query: 866 LHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESDTRYFFKMGA 925
L W P + V + ILY+ + G+ + L+ +T Y F +
Sbjct: 1021 LSWEVP-DSYKSAVPFKILYNGQSVE---------VDGHSMRKLIADLQPNTEYSFVLMN 1070
Query: 926 RTEVGPGPFSRLQDVITLQ 944
R G LQ +++++
Sbjct: 1071 RGSSAGG----LQHLVSIR 1085
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform
2 precursor [Homo sapiens]
Length = 1899
Score = 183 bits (465), Expect = 8e-46
Identities = 216/837 (25%), Positives = 344/837 (41%), Gaps = 95/837 (11%)
Query: 145 FSLHPESQTVEENGTARFECHIEGLPAPIITWEKDQVTLPEEP-RLIVLPNGVLQILDVQ 203
F+ P QT G A F C G P P I W K + + +I +G +L +Q
Sbjct: 26 FTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQ 85
Query: 204 E----SDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQ 259
D Y CVA+N+ + S L+V + RG + + P+ V +
Sbjct: 86 PLRTPRDEAIYECVASNNVGE-ISVSTRLTVLREDQIP--RGFPTIDMG-PQLKVVERTR 141
Query: 260 SVVMECVASADPTPFVSWVRQDGKPISTD-----VIVLGRTNLLIANAQPWHSGVYVCRA 314
+ M C AS +P P ++W + D P+ T + L L I ++ G Y C A
Sbjct: 142 TATMLCAASGNPDPEITWFK-DFLPVDTSNNNGRIKQLRSGALQIEQSEESDQGKYECVA 200
Query: 315 -NKPRTRDFATAAAELRVLAAPAITQAPEALSRTR-ASTARFVCRASGEPRPALRWLHNG 372
N TR A A +RV P P + C A G P P ++W+
Sbjct: 201 TNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGA 260
Query: 373 APLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAVVVREGLPSAP 432
L P + + G V+ ++ + Y CVA ++ G+ A A + V + LP P
Sbjct: 261 EDLTPEDDMPI----GRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV---KALPKPP 313
Query: 433 TRVTATPLSSSAVLVAWE--RPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQV 490
T +++++ + W+ PE S II K + + + Y+ TT V
Sbjct: 314 GTPVVTESTATSITLTWDSGNPEPVSYYII-----QHKPKNSEEL-YKEIDGVATTRYSV 367
Query: 491 RDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQ-LSLSSPNPSDIRVAWLP 549
L P +DYEF VVA + +G S P L T + PS+AP+ + + + I V W
Sbjct: 368 AGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW-- 425
Query: 550 LPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGN--ETQL-MLNSLQPNKVYRVRISAGTA 606
P NGQ+ Y++ Y + + + ++ N ++Q+ + +L P K Y V++ A T+
Sbjct: 426 KEPEEPNGQIQGYRVYYTMDPTQHV-NNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTS 484
Query: 607 AGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQAKME-SLVVSWQPPPHPTQISGYKLYW 665
G G S + T Q+ VP P K + + E S+++SW PP T I+ Y+L +
Sbjct: 485 IGDGPLSSDIQVIT-----QTGVPGQPLNFKAEPESETSILLSWTPPRSDT-IANYELVY 538
Query: 666 REVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHED 725
++ EE PG Y L L P LY +L A +
Sbjct: 539 KDGEHGEEQRITIEPG------------------TSYRLQGLKPNSLYYFRLAA--RSPQ 578
Query: 726 GYAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVK--IVNY 783
G A T + A M Q P PP + S SSTSI + W+ P I Y
Sbjct: 579 GLGA----STAEISARTM--QSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEY 632
Query: 784 TVRFSPWGLRN--ASLVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERS 841
+++++ + + S L+ L+ +T+Y V +H GP V
Sbjct: 633 SIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIR 692
Query: 842 TLPDRPSTPPSDLRLSPLTPSTVRLHWCP--PTEPNGEIVEYLILY-----SSNHTQP-- 892
T D PS PP + + + ++V++ W P + +G+I Y + Y QP
Sbjct: 693 TNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPML 752
Query: 893 ------EHQWTL-LTTQGNIFSAEVHGLESDTRYFFKMGARTEVGPGPFSRLQDVIT 942
+ QW TT+ ++ + GL+ +T Y + A T G G S+ + V T
Sbjct: 753 KDVMLADAQWEFDDTTEHDMI---ISGLQPETSYSLTVTAYTTKGDGARSKPKLVST 806
Score = 158 bits (400), Expect = 3e-38
Identities = 221/936 (23%), Positives = 377/936 (40%), Gaps = 112/936 (11%)
Query: 40 VGPLQVILGPEQAAVLNCSLGAAAAGPPTRVTWSKDG---DTLLEHDHLHLLPNGSLWLS 96
+GP ++ + A + C AA+ P +TW KD DT + + L +G+L +
Sbjct: 130 MGPQLKVVERTRTATMLC---AASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIE 186
Query: 97 QPLAPNGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTA--VVKLATLAD-FSLHPESQT 153
Q S+ES +G Y C+A G S A V++ + FS+ P +
Sbjct: 187 Q------SEESD-------QGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHE 233
Query: 154 VEENGTARFECHIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCV 213
+ G+ C G P P + W L E + + N VL++ DV++S Y CV
Sbjct: 234 IMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRN-VLELNDVRQS--ANYTCV 290
Query: 214 ATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVA--SADP 271
A ++ G + + V + P T VV+ + + S +P
Sbjct: 291 AMSTL---------------GVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNP 335
Query: 272 TPFVSWVRQ----DGKPISTDVIVLGRTNLLIANAQPWHSGVY-VCRANK----PRTRDF 322
P ++ Q + + + ++ + T +A P+ + V N P +
Sbjct: 336 EPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPV 395
Query: 323 ATAAAELRVLAAPAITQAPEALSRTRASTARFV-CRASGEPRPALRWLHNGAPLRPNGRV 381
T +E +AP QA R +ST V + EP ++ + P V
Sbjct: 396 LTQTSEQAPSSAPRDVQA-----RMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHV 450
Query: 382 K--VQGGGGSLVITQIGL---QDAGYYQCVAENSAGMACAAASLAVVVREGLPSAPTRVT 436
++ IT IG Q + +A S G ++ + V+ + G+P P
Sbjct: 451 NNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK 510
Query: 437 ATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPN 496
A P S +++L++W P S+ I + L Y+ ++ E Q T +++ L+PN
Sbjct: 511 AEPESETSILLSWTPPR--SDTIANYELVYKDG---EHGEEQRITIEPGTSYRLQGLKPN 565
Query: 497 TDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQ-LSLSSPNPSDIRVAWLPLPPSLS 555
+ Y F + A S G ++ T+ PSA PQ +S +SP+ + I V+W P P
Sbjct: 566 SLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQ 625
Query: 556 NGQVVKYKIEYGLGKEDQIFSTEVRG---NETQLMLNSLQPNKVYRVRISAGTAAGFGAP 612
NG + +Y I+Y + E+ G + T+ +L L+ YR+ ++A T G G
Sbjct: 626 NGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPE 685
Query: 613 SQWMHHRTPSMHNQSHVPFAPAELKVQA-KMESLVVSWQPP---PHPTQISGYKLYWREV 668
S + RT N+ P +++V+A S+ VSW+ P QI GY++++ +
Sbjct: 686 SLSVLIRT----NEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRM 741
Query: 669 GAEEEANGDRLPGGR-GDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGY 727
E L D W+ + ++ L P Y + + A+ DG
Sbjct: 742 ENGEPKGQPMLKDVMLADAQWEFDDTTEHDMI----ISGLQPETSYSLTVTAYTTKGDGA 797
Query: 728 AAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRF 787
+ K + P P H + N++ ++W P T + Y ++F
Sbjct: 798 RSKPKLVSTTGAVPGKPRL-------VINHTQMNTAL---IQWHPPVDTFGPLQGYRLKF 847
Query: 788 SPWGLRNASLVTYYTSSGEDILIG-GLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDR 846
+ L T S ED + Y F + + G +V+ ++P+
Sbjct: 848 GRKDME--PLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGE--EMVKEISIPEE 903
Query: 847 -PSTPPSDLRLSPLTPSTVRLHWCPPT--EPNGEIVEYLILYSSNHTQPEHQWTLLTTQG 903
P+ P +L T ++V+L W PP E NG I +Y +LY + LL +
Sbjct: 904 VPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIP------LLPMEQ 957
Query: 904 NIFSAE----VHGLESDTRYFFKMGARTEVGPGPFS 935
I A+ + GL+ DT Y K+ A T GPGP+S
Sbjct: 958 LIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYS 993
Score = 133 bits (335), Expect = 9e-31
Identities = 127/554 (22%), Positives = 233/554 (42%), Gaps = 70/554 (12%)
Query: 402 YYQCVAENSAGMACAAASLAVVVREGLPSAPTR-VTATPLSSSAVLVAWERPEMHSEQ-- 458
Y++ A + G+ + A ++ + PSAP + ++ T SS+++LV+W+ P + +
Sbjct: 569 YFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGI 628
Query: 459 IIGFSLHYQKARGMDNVEYQF-AVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTP 517
I +S+ Y G D+ ++ + +DTT+ + LE T+Y V A++ +G S
Sbjct: 629 ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLS 688
Query: 518 ALVHTLDDVPSAAPQ-LSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEY---------- 566
L+ T +DVPS P+ + + + N + ++V+W P+ +GQ+ Y++ Y
Sbjct: 689 VLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKG 748
Query: 567 -GLGKEDQIFSTEVRGNET---QLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPS 622
+ K+ + + ++T ++++ LQP Y + ++A T G GA S +
Sbjct: 749 QPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARS-----KPKL 803
Query: 623 MHNQSHVPFAPAELKVQAKMESLVVSWQPPPHPTQISGYKLYWREVGAEEEANGDRLPGG 682
+ VP P + +M + ++ W PP V G RL G
Sbjct: 804 VSTTGAVPGKPRLVINHTQMNTALIQWHPP---------------VDTFGPLQGYRLKFG 848
Query: 683 RGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPD 742
R D + + +K + T + G Y +L A NK G V K P
Sbjct: 849 RKDME-PLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMV---KEISIP--- 901
Query: 743 MPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVK--IVNYTVRFSPWGLRNASLVTY 800
+ P P ++H+E +STS+ L W+ P I YT+ + + +
Sbjct: 902 ---EEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQL 958
Query: 801 YTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRLSPLT 860
+ + + GLKP T Y+ V++H GP+ V+ TLP + + +
Sbjct: 959 IVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLP-VDQVFAKNFHVKAVM 1017
Query: 861 PSTVRLHWCPPTEPNGEIVEYLILYSSN----------------HTQPEHQWT-LLTTQG 903
++V L W P N + + ILY + +PE ++ +LT +G
Sbjct: 1018 KTSVLLSWEIPENYN-SAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRG 1076
Query: 904 NIFSAEVHGLESDT 917
N H + + T
Sbjct: 1077 NSAGGLQHRVTAKT 1090
Score = 92.8 bits (229), Expect = 2e-18
Identities = 140/637 (21%), Positives = 251/637 (39%), Gaps = 86/637 (13%)
Query: 335 PAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVKV----QGGGGSL 390
P T+ P + A F+C+A+G+PRP + W G + N R +V G G L
Sbjct: 24 PRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVS-NQRFEVIEFDDGSGSVL 82
Query: 391 VITQIGL-QDAGYYQCVAENSAGMACAAASLAVVVREGLPSA-PT-------RVTATPLS 441
I + +D Y+CVA N+ G + L V+ + +P PT +V +
Sbjct: 83 RIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRT 142
Query: 442 SSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTE------LQVRDLEP 495
++ + A P+ +I F D + + NN + LQ+ E
Sbjct: 143 ATMLCAASGNPD---PEITWFK---------DFLPVDTSNNNGRIKQLRSGALQIEQSEE 190
Query: 496 NTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLS 555
+ ++ VA + G +R S PA ++ V P+ S+ P +I ++
Sbjct: 191 SDQGKYECVATNSAG-TRYSAPANLYVR--VRRVPPRFSIP-PTNHEIMPGGSVNITCVA 246
Query: 556 NGQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQW 615
G + Y +++ LG ED ++ L LN ++ + Y ++ T A +Q
Sbjct: 247 VGSPMPY-VKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTC-VAMSTLGVIEAIAQI 304
Query: 616 MHHRTPSMHNQSHVPFAPAELKVQAKMESLVVSWQPPPHPTQISGYKLYWREVGAEE--- 672
P P P + ++ S+ ++W +P +S Y + + +EE
Sbjct: 305 TVKALPKP------PGTP--VVTESTATSITLTWDSG-NPEPVSYYIIQHKPKNSEELYK 355
Query: 673 EANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWK 732
E +G +Y + L P YE ++VA N + +
Sbjct: 356 EIDG--------------------VATTRYSVAGLSPYSDYEFRVVAVNN-------IGR 388
Query: 733 GKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRFSPWGL 792
G + P ++ P P V A SST+I ++WK+P+ +I Y V ++
Sbjct: 389 GPPSE-PVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPT 447
Query: 793 RNAS-LVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPP 851
++ + + + + + IG L P Y V + DGP S ++ T P P
Sbjct: 448 QHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP- 506
Query: 852 SDLRLSPLTPSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVH 911
+ + P + +++ L W PP I Y ++Y E + T+ S +
Sbjct: 507 LNFKAEPESETSILLSWTPPRSDT--IANYELVYKDGEHGEEQRITIEPGT----SYRLQ 560
Query: 912 GLESDTRYFFKMGARTEVGPGPFSRLQDVITLQEKLS 948
GL+ ++ Y+F++ AR+ G G + T+Q K S
Sbjct: 561 GLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPS 597
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 183 bits (464), Expect = 1e-45
Identities = 221/869 (25%), Positives = 342/869 (39%), Gaps = 97/869 (11%)
Query: 117 GNYSCLAHGPLGVL--ASQTAVVKLATLADFSLHPESQ-TVEENGTARFECHIEGLPAPI 173
G Y C A P A TA + + F+ PES+ + E T C G+P P
Sbjct: 358 GPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPT 417
Query: 174 ITWEKDQVTLP--EEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEALLSVA 231
+ W KD +++ + PR VL +G L+I ++ D+G ++C A+N + L V
Sbjct: 418 LQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGE-IQTHTYLDVT 476
Query: 232 HRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTDV-- 289
+ + + R P +TTV G + ++ C S P P ++W R++ S V
Sbjct: 477 NIAPVFTQR---------PVDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRI 527
Query: 290 ---IVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEALSR 346
++L L IA +G Y C A T A+A L V +I PE
Sbjct: 528 PRFMLLESGGLQIAPVFIQDAGNYTCYA--ANTEGSLNASATLTVWNRTSIVHPPEDHVV 585
Query: 347 TRASTARFVCRASGEPRPALR--WLHNGAPLRPNGRVK-VQGGGGSLVITQIGLQDAGYY 403
+ +TA C A+ +PR +LR W + L P+ + V GSL+I+Q D G Y
Sbjct: 586 IKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDY 645
Query: 404 QCVAENSAGMACAAASLAVVVREGLPSAPTRVTATPLSSS--AVLVAWERPEMHSEQIIG 461
C + G A L V+ LP +P + +P SS AV+++W RP + I
Sbjct: 646 SCEIVSEGGNDSRMARLEVIE---LPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPI-- 700
Query: 462 FSLHYQKARGMDNVEYQFAVNN---DTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPA 518
L+Y +N ++ ++N + T + V L P Y+F V A +++G + S
Sbjct: 701 --LYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAET 758
Query: 519 LVHTLDDVPSAAPQLSL--SSPNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLG------K 570
L + P +AP ++ S I V W P P + NG + Y + Y L +
Sbjct: 759 SRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQ 818
Query: 571 EDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVP 630
+ I S EV ++ L Y ++++A AG G S R + + VP
Sbjct: 819 QRNITSPEVN----YCLVTDLIIWTQYEIQVAAYNGAGLGVFS-----RAVTEYTLQGVP 869
Query: 631 FAPAELKVQAKMESLVVS--WQPPPHPTQIS---GYKLY-WREVGAEEEANGDRLPGGRG 684
AP + + S + W PPP GYKL W E P G
Sbjct: 870 TAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHG 929
Query: 685 DQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAA----VWKGKTEKAPA 740
V +T L Y ++ F DG + VW
Sbjct: 930 --------------VHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWT-------- 967
Query: 741 PDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRFSPWGLRNASLVTY 800
Q P H+ TS+ + W++P I Y + + +G ++ L
Sbjct: 968 -----QEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHT 1022
Query: 801 YTSSGEDILIGGLKPFTKYEFAVQS-HGVDMDGPFGSVVERSTLPDRPSTPPSDLRLSPL 859
S+ + I GL T Y V + V S + PD P PS+L +S +
Sbjct: 1023 LNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGA-PSNLVISNI 1081
Query: 860 TPSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSA---EVHGLESD 916
+P + L + P + I +++ E +W L + N A E+ L
Sbjct: 1082 SPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPY 1141
Query: 917 TRYFFKMGARTEVGPGPFSRLQDVI-TLQ 944
T Y F+M VGP P+S VI TLQ
Sbjct: 1142 THYRFRMKQVNIVGPSPYSPSSRVIQTLQ 1170
Score = 151 bits (382), Expect = 3e-36
Identities = 222/920 (24%), Positives = 354/920 (38%), Gaps = 100/920 (10%)
Query: 59 LGAAAAGPPT-RVTWSKDGDTL--LEHDHLHLLPNGSLWLSQPLAPNGSDESVPEAVGVI 115
+G A G P + W KD ++ L++ +L +G L + Q L P S
Sbjct: 406 IGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRI-QKLRPEDS----------- 453
Query: 116 EGNYSCLAHGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTARFECHIEGLPAPIIT 175
G + C A G + + T + F+ P TV + TA C + G P P IT
Sbjct: 454 -GIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAIT 512
Query: 176 WEKDQVTLPEE----PRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEALLSVA 231
W+++ L PR ++L +G LQI V DAG Y C A N+ + A L+V
Sbjct: 513 WKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGS-LNASATLTVW 571
Query: 232 HRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWV-RQDG---KPIST 287
+R S IV PE+ V+ G + + C A+ DP + +V ++D P ST
Sbjct: 572 NRTS----------IVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSST 621
Query: 288 DVIVLGRT-NLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQ----APE 342
IV+ + +LLI+ G Y C D + A L V+ P Q +P
Sbjct: 622 SRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGND--SRMARLEVIELPHSPQNLLVSPN 679
Query: 343 ALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLV-ITQIGLQDAG 401
+ S + A +V G P L ++ + +V + G + +T GL A
Sbjct: 680 S-SHSHAVVLSWVRPFDGNS-PILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPAR 737
Query: 402 YYQ----CVAENSAGMACAAASLAVVVREGLPSAPTRVTATPLSSSAVLVAWERPEM--H 455
YQ V E G A S ++ E + P + A+ ++ +++V W+ P H
Sbjct: 738 TYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEH 797
Query: 456 SEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTS 515
+ + G+ L Y+ A + + + + V DL T YE V AY+ G S
Sbjct: 798 NGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFS 857
Query: 516 TPALVHTLDDVPSAAPQ-LSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKEDQI 574
+TL VP+A PQ + + N + I+ W P P NG YK+ +
Sbjct: 858 RAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEA 917
Query: 575 FSTEVRGNETQLM----LNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSM-HNQSHV 629
+ + + + +L+ Y + T G G PS TP + Q
Sbjct: 918 VTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPS------TPQLVWTQEDK 971
Query: 630 PFAPAELKVQAKME-SLVVSWQPPPHPTQI-SGYKLYWREVGAEEEANGDRLPGGRGDQA 687
P A L ++ SL VSWQ P I +GY++ W G N RL
Sbjct: 972 PGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGR----NDSRLTH------ 1021
Query: 688 WDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQR 747
L +Y++ L Y + + A G V PD+P
Sbjct: 1022 ------TLNSTTHEYKIQGLSSLTTYTIDVAAVTAV--GTGLVTSSTISSGVPPDLPGA- 1072
Query: 748 GPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRFSPWGLRNAS-LVTYYTSSGE 806
P+++ + S S L+++ I + V + + VT Y E
Sbjct: 1073 -----PSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENE 1127
Query: 807 D----ILIGGLKPFTKYEFAVQSHGVDMDGPFG-SVVERSTLPDRPSTPPSDLRLSPLTP 861
+ I L P+T Y F ++ + P+ S TL P P+ + + +
Sbjct: 1128 PDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASE 1187
Query: 862 STVRLHWCPPTEP----NGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESDT 917
+++RL W P + N E V Y I Y + Q +++ + + LE
Sbjct: 1188 TSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLER-EFTIEELEEWM 1246
Query: 918 RYFFKMGARTEVGPGPFSRL 937
Y +M A VG GP+S +
Sbjct: 1247 EYELQMQAFNAVGAGPWSEV 1266
Score = 117 bits (294), Expect = 5e-26
Identities = 124/475 (26%), Positives = 202/475 (42%), Gaps = 52/475 (10%)
Query: 431 APTRVTATPLSSSAVLVAW----ERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTT 486
APT VT S +++ + W + + + +G+ + Y ++ + Q +
Sbjct: 1176 APTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLER 1235
Query: 487 ELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQ-LSLSSPNPSDIRV 545
E + +LE +YE + A++ +GA S T + VPSAAP+ +S + + + I +
Sbjct: 1236 EFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILL 1295
Query: 546 AWLPLPPSLSNGQVVKYKIEYGLGKED-QIFSTEVRGNETQ-LMLNSLQPNKVYRVRISA 603
W +P NG ++ YKI + D + S VRGN TQ +L L+ +Y +++ A
Sbjct: 1296 TWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLA 1355
Query: 604 GTAAGFGAPSQWMHHRTPSM--HNQSHVPFAPAELKV-QAKMESLVVSWQPPPHPTQ-IS 659
T G G PS TP + + P P L + ++ S+ + WQPP P I
Sbjct: 1356 FTRIGNGVPS------TPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIIL 1409
Query: 660 GYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVA 719
GY++ +R + V + V+Q+ T L P Y +L A
Sbjct: 1410 GYQIAYRLASSSPHT---------------FTTVEVGATVRQFTATDLAPESAYIFRLSA 1454
Query: 720 FNKHEDGYAAVWKG---KTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFT 776
K G+ + TEK P P R +P A V A S+ L+W
Sbjct: 1455 --KTRQGWGEPLEATVITTEKRERPAPP--RELLVPQAEVTAR-----SLRLQWVPGSDG 1505
Query: 777 TVKIVNYTVRFSPWGLRNASLVTYYTSSGED---ILIGGLKPFTKYEFAVQSHGVDMDGP 833
I +T++ L TY +S + ++ L+PFT Y+ +++ D
Sbjct: 1506 ASPIRYFTMQVRE--LPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSD 1563
Query: 834 FGSVVER-STLPDRPSTPPSDLRLSPLTPSTVRLHWCPPTEP--NGEIVEYLILY 885
F S E +TL D P PP + +P T S+V + W PP + NG + Y I Y
Sbjct: 1564 FSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYY 1618
Score = 114 bits (285), Expect = 6e-25
Identities = 140/578 (24%), Positives = 233/578 (40%), Gaps = 66/578 (11%)
Query: 404 QCVAENSAGMACAAASLAVVVREGLPSA-PTRVTATPLSSSAVLVAWER-PEM-HSEQII 460
Q A N+ G + + RE +PSA P V+A +SS+ +L+ W PE + I+
Sbjct: 1251 QMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLIL 1310
Query: 461 GFSLHYQKARGMDNVEYQFAV-NNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPAL 519
G+ + + +A+ +D V N T + L YE V+A++++G STP +
Sbjct: 1311 GYKILF-RAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLI 1369
Query: 520 V-HTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKED-QIFST 577
+ T DD P +L + +R+ W PP NG ++ Y+I Y L F+T
Sbjct: 1370 LERTKDDAPGPPVRLVFPEVRLTSVRIVW--QPPEEPNGIILGYQIAYRLASSSPHTFTT 1427
Query: 578 -EVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAEL 636
EV Q L P Y R+SA T G+G P + T + P P EL
Sbjct: 1428 VEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLE----ATVITTEKRERPAPPREL 1483
Query: 637 KV-QAKMESLVVSWQPPPHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRL 695
V QA++ + + Q P S + + +V LP G W +
Sbjct: 1484 LVPQAEVTARSLRLQWVPGSDGASPIRYFTMQV--------RELPRGE----WQTYSSSI 1531
Query: 696 KKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQRGPPLPPAH 755
+ + +L P Y+++L A N D + + +TE +Q P PP
Sbjct: 1532 SHEATACVVDRLRPFTSYKLRLKATNDIGD---SDFSSETEAVTT----LQDVPGEPPGS 1584
Query: 756 VHAESNSSTSIWLRWKKP------------------------DFTTVKIVNYTVRFSPWG 791
V A ++++S+ ++W+ P T K + +
Sbjct: 1585 VSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAEL 1644
Query: 792 LRNASLVTYYTSSGEDIL-IGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTP 850
+S T +SS + + LK + +YE + ++ + + P + VE P+
Sbjct: 1645 TAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMA 1704
Query: 851 PSDLRLSPLTPSTVRLHW--CPPTEPNGEIVEYLILY--SSNHTQPEHQWTLLTTQGNIF 906
P +++++PLT S + + W PP NG I Y I Y + + + E L + +
Sbjct: 1705 PQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVV- 1763
Query: 907 SAEVHGLESDTRYFFKMGARTEVGPGPFSRLQDVITLQ 944
+ L S T+Y + A G GP S Q T Q
Sbjct: 1764 --RLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQ 1799
Score = 108 bits (271), Expect = 2e-23
Identities = 89/313 (28%), Positives = 140/313 (44%), Gaps = 11/313 (3%)
Query: 108 VPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTARFEC-HI 166
+P + G Y C+ +G L + + V++A + F + +TV + A I
Sbjct: 156 IPSLQKLDAGFYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPI 215
Query: 167 EGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEA 226
P P +TW ++ + R+ + L IL SDAG Y A N
Sbjct: 216 TSYPRPQVTWFREGHKIIPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSP 275
Query: 227 LLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQS-VVMECVASADPTP--FVSWVRQDGK 283
+ ++ + + IV P N +VV+G S +EC+ASA P V+W +++G
Sbjct: 276 FIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTW-KRNGV 334
Query: 284 PISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTR-DFATAAAELRVLAAPAITQAPE 342
I++ + GR L I+N +G YVC A P + + A A A L ++ P T PE
Sbjct: 335 RITSGLHSFGR-RLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPE 393
Query: 343 A-LSRTRASTARFVCRASGEPRPALRWLHNGAPLR--PNGRVKVQGGGGSLVITQIGLQD 399
+ +S T C+A G P P L+W + + N R KV GG L I ++ +D
Sbjct: 394 SRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGG-LRIQKLRPED 452
Query: 400 AGYYQCVAENSAG 412
+G +QC A N G
Sbjct: 453 SGIFQCFASNEGG 465
Score = 107 bits (267), Expect = 7e-23
Identities = 130/529 (24%), Positives = 223/529 (42%), Gaps = 50/529 (9%)
Query: 422 VVVREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAV 481
V +E P A ++ T + +++ V+W+ P + I G+ + ++ G ++ +
Sbjct: 965 VWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWE-VYGRNDSRLTHTL 1023
Query: 482 NNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLD-DVPSAAPQLSLSSPNP 540
N+ T E +++ L T Y V A + +G ++ + + D+P A L +S+ +P
Sbjct: 1024 NSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISP 1083
Query: 541 SDIRVAWLPLPPSLSNGQVVKYKIEYG----LGKEDQ---IFSTEVRGNETQLMLNSLQP 593
R A L P + I G +G E++ ++ E + L + +L P
Sbjct: 1084 ---RSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTP 1140
Query: 594 NKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQAKME-SLVVSWQPP 652
YR R+ G PS + Q+ AP + V+ E SL + W P
Sbjct: 1141 YTHYRFRMKQVNIVG---PSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPL 1197
Query: 653 PHPTQISGYKLYWREVGAEEEANGDRLPGGRGD-QAWDVGPVRLKKKVKQYELTQLVPGR 711
P +Q +G E+ G R+ R D Q+ V V + +++ + +L
Sbjct: 1198 PD-SQYNG----------NPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWM 1246
Query: 712 LYEVKLVAFNKHEDG-YAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRW 770
YE+++ AFN G ++ V +G+T ++ P P +V AE+ SST I L W
Sbjct: 1247 EYELQMQAFNAVGAGPWSEVVRGRTRESV---------PSAAPENVSAEAVSSTQILLTW 1297
Query: 771 KKPDFTTVK--IVNYTVRFSPWGL----RNASLVTYYTSSGEDILIGGLKPFTKYEFAVQ 824
I+ Y + F L R+ + +T S L+ GL+ F YE V
Sbjct: 1298 TSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSA---LLAGLRKFVLYELQVL 1354
Query: 825 SHGVDMDG-PFGSVVERSTLPDRPSTPPSDLRLSPLTPSTVRLHWCPPTEPNGEIVEYLI 883
+ +G P ++ T D P PP L + ++VR+ W PP EPNG I+ Y I
Sbjct: 1355 AFTRIGNGVPSTPLILERTKDDAPG-PPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQI 1413
Query: 884 LYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESDTRYFFKMGARTEVGPG 932
Y + P H +T + + L ++ Y F++ A+T G G
Sbjct: 1414 AYRLASSSP-HTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWG 1461
Score = 94.0 bits (232), Expect = 8e-19
Identities = 133/628 (21%), Positives = 235/628 (37%), Gaps = 63/628 (10%)
Query: 340 APEALSRTRASTARFVCRASGEPRP-------ALRWLHNGAPLRPNGRVKVQGGGGSLVI 392
APE +S S+ + + + P + L L P R + G +
Sbjct: 1279 APENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSA 1338
Query: 393 TQIGLQDAGYY--QCVAENSAGMACAAASLAVV-VREGLPSAPTRVTATPLSSSAVLVAW 449
GL+ Y Q +A G + L + ++ P P R+ + ++V + W
Sbjct: 1339 LLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVW 1398
Query: 450 ERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQL 509
+ PE + I+G+ + Y+ A + V + DL P + Y F + A ++
Sbjct: 1399 QPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQ 1458
Query: 510 GASRTSTPALVHTLDDVPSAAPQLSLSSPNPS----DIRVAWLPLPPSLSNGQVVKYKIE 565
G A V T + AP L P +R+ W+P S + ++
Sbjct: 1459 GWGE-PLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVR 1517
Query: 566 YGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHN 625
E Q +S+ + T +++ L+P Y++R+ A G S T ++
Sbjct: 1518 ELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSS----ETEAVTT 1573
Query: 626 QSHVPFAP--AELKVQAKMESLVVSWQPPPHPT---QISGYKLYWREVGAEEEANGDRLP 680
VP P + S+++ WQPP + + GY++Y+RE+ E
Sbjct: 1574 LQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYE--------- 1624
Query: 681 GGRGDQAWDV-GPVRLKKKV---------------KQYELTQLVPGRLYEVKLVAFNKHE 724
G G +A + P+ L ++ ELT L R YEV + A+N
Sbjct: 1625 AGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIG 1684
Query: 725 DGYAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRW--KKPDFTTVKIVN 782
+ A+ AP + P + P +V +++ + + W P+ I
Sbjct: 1685 ESPAS--------APVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQG 1736
Query: 783 YTVRFSPWGLRNASLVTYYTSSGEDIL-IGGLKPFTKYEFAVQSHGVDMDGPFGSVVERS 841
Y + + +N + E ++ + L TKY ++ + DGP +
Sbjct: 1737 YKIYYWEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGR 1796
Query: 842 TLPDRPSTPPSDLRLSPLTPSTVRLHWCPPTEPNGEIVEYLILYSS-NHTQPEHQWTLLT 900
T P PS L S +T +T+ + W P NG + Y ++Y Q + +
Sbjct: 1797 THQAAPGA-PSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVE 1855
Query: 901 TQGNIFS-AEVHGLESDTRYFFKMGART 927
+GN +V L YFF++ ART
Sbjct: 1856 VRGNWQRWLKVRDLTKGVTYFFRVQART 1883
Score = 66.6 bits (161), Expect = 1e-10
Identities = 64/265 (24%), Positives = 113/265 (42%), Gaps = 13/265 (4%)
Query: 688 WDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQR 747
W V + ++ ++ L P R Y+ ++ A N+ G + +T + P+ P
Sbjct: 714 WKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQ---YSAETSRLMLPEEP--- 767
Query: 748 GPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIV--NYTVRFSPWGLRNASLVTYYTSSG 805
P PP ++ A ++ SI ++W+ P T V Y +R+ GL TS
Sbjct: 768 -PSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPE 826
Query: 806 EDI-LIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRLSPLTPSTV 864
+ L+ L +T+YE V ++ G F V TL P+ PP +++ + +T+
Sbjct: 827 VNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTI 886
Query: 865 RLHWCPPTEP--NGEIVEY-LILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESDTRYFF 921
+ W PP + NG Y L+ + ++ + T+ + + L+ T YF
Sbjct: 887 QFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFT 946
Query: 922 KMGARTEVGPGPFSRLQDVITLQEK 946
+ T G GP S Q V T ++K
Sbjct: 947 SVLCFTTPGDGPPSTPQLVWTQEDK 971
Score = 40.8 bits (94), Expect = 0.008
Identities = 47/200 (23%), Positives = 84/200 (42%), Gaps = 20/200 (10%)
Query: 426 EGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVN--- 482
+ P AP+ + + ++S+ + V+W P + + G+ + Y+ + V V
Sbjct: 1799 QAAPGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRG 1858
Query: 483 NDTTELQVRDLEPNTDYEFYVVAYS-----QLGASRTSTPALVHTLDDVPSAAPQLSLSS 537
N L+VRDL Y F V A + +L A+ T+ PA + +P+ L +
Sbjct: 1859 NWQRWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGPA------EGSPGSPRDVLVT 1912
Query: 538 PNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKED--QIFSTEVRGNETQ--LMLNSLQP 593
+ S++ + W + Y IE E +F ++ + T L L+ L+
Sbjct: 1913 KSASELTLQWTE--GHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQ 1970
Query: 594 NKVYRVRISAGTAAGFGAPS 613
Y R+ A AG+G PS
Sbjct: 1971 GVTYEFRVVAVNEAGYGEPS 1990
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform
3 precursor [Homo sapiens]
Length = 1903
Score = 178 bits (452), Expect = 3e-44
Identities = 214/838 (25%), Positives = 343/838 (40%), Gaps = 93/838 (11%)
Query: 145 FSLHPESQTVEENGTARFECHIEGLPAPIITWEKDQVTLPEEP-RLIVLPNGVLQILDVQ 203
F+ P QT G A F C G P P I W K + + +I +G +L +Q
Sbjct: 26 FTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQ 85
Query: 204 E----SDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQ 259
D Y CVA+N+ + S L+V + RG + + P+ V +
Sbjct: 86 PLRTPRDEAIYECVASNNVGE-ISVSTRLTVLREDQIP--RGFPTIDMG-PQLKVVERTR 141
Query: 260 SVVMECVASADPTPFVSWVRQDGKPISTD-----------VIVLG---RTNLLIANAQPW 305
+ M C AS +P P ++W + D P+ T + G R L I ++
Sbjct: 142 TATMLCAASGNPDPEITWFK-DFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEES 200
Query: 306 HSGVYVCRA-NKPRTRDFATAAAELRVL-----AAPAITQAPEALSRTRASTARFVCRAS 359
G Y C A N TR A A +R L P + P + C A
Sbjct: 201 DQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAV 260
Query: 360 GEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAAAS 419
G P P ++W+ L P + + G V+ ++ + Y CVA ++ G+ A A
Sbjct: 261 GSPMPYVKWMLGAEDLTPEDDMPI----GRNVLELNDVRQSANYTCVAMSTLGVIEAIAQ 316
Query: 420 LAVVVREGLPSAPTRVTATPLSSSAVLVAWE--RPEMHSEQIIGFSLHYQKARGMDNVEY 477
+ V + LP P T +++++ + W+ PE S II K + + + Y
Sbjct: 317 ITV---KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYII-----QHKPKNSEEL-Y 367
Query: 478 QFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQ-LSLS 536
+ TT V L P +DYEF VVA + +G S P L T + PS+AP+ +
Sbjct: 368 KEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQAR 427
Query: 537 SPNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGN--ETQL-MLNSLQP 593
+ + I V W P NGQ+ Y++ Y + + + ++ N ++Q+ + +L P
Sbjct: 428 MLSSTTILVQW--KEPEEPNGQIQGYRVYYTMDPTQHV-NNWMKHNVADSQITTIGNLVP 484
Query: 594 NKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQAKME-SLVVSWQPP 652
K Y V++ A T+ G G S + T Q+ VP P K + + E S+++SW PP
Sbjct: 485 QKTYSVKVLAFTSIGDGPLSSDIQVIT-----QTGVPGQPLNFKAEPESETSILLSWTPP 539
Query: 653 PHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRL 712
T I+ Y+L +++ EE PG Y L L P L
Sbjct: 540 RSDT-IANYELVYKDGEHGEEQRITIEPG------------------TSYRLQGLKPNSL 580
Query: 713 YEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKK 772
Y +L A + G A T + A M Q P PP + S SSTSI + W+
Sbjct: 581 YYFRLAA--RSPQGLGA----STAEISARTM--QSKPSAPPQDISCTSPSSTSILVSWQP 632
Query: 773 PDFTTVK--IVNYTVRFSPWGLRN--ASLVTYYTSSGEDILIGGLKPFTKYEFAVQSHGV 828
P I Y+++++ + + S L+ L+ +T+Y V +H
Sbjct: 633 PPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTD 692
Query: 829 DMDGPFGSVVERSTLPDRPSTPPSDLRLSPLTPSTVRLHWCP--PTEPNGEIVEYLILY- 885
GP V T D PS PP + + + ++V++ W P + +G+I Y + Y
Sbjct: 693 VGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYV 752
Query: 886 SSNHTQPEHQWTLLTTQ-GNIFSAEVHGLESDTRYFFKMGARTEVGPGPFSRLQDVIT 942
+ +P+ Q L + + GL+ +T Y + A T G G S+ + V T
Sbjct: 753 RMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVST 810
Score = 152 bits (384), Expect = 2e-36
Identities = 222/942 (23%), Positives = 380/942 (40%), Gaps = 120/942 (12%)
Query: 40 VGPLQVILGPEQAAVLNCSLGAAAAGPPTRVTWSKDG---DTLLEHDHLHLLPNGSLW-- 94
+GP ++ + A + C AA+ P +TW KD DT + + L + S+
Sbjct: 130 MGPQLKVVERTRTATMLC---AASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGT 186
Query: 95 -LSQPLAPNGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLAD-------FS 146
+ L S+ES +G Y C+A G S A + + L + FS
Sbjct: 187 PIRGALQIEQSEESD-------QGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFS 239
Query: 147 LHPESQTVEENGTARFECHIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESD 206
+ P + + G+ C G P P + W L E + + N VL++ DV++S
Sbjct: 240 IPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRN-VLELNDVRQS- 297
Query: 207 AGPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECV 266
Y CVA ++ G + + V + P T VV+ + +
Sbjct: 298 -ANYTCVAMSTL---------------GVIEAIAQITVKALPKPPGTPVVTESTATSITL 341
Query: 267 A--SADPTPFVSWVRQ----DGKPISTDVIVLGRTNLLIANAQPWHSGVY-VCRANK--- 316
S +P P ++ Q + + + ++ + T +A P+ + V N
Sbjct: 342 TWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGR 401
Query: 317 -PRTRDFATAAAELRVLAAPAITQAPEALSRTRASTARFV-CRASGEPRPALRWLHNGAP 374
P + T +E +AP QA R +ST V + EP ++
Sbjct: 402 GPPSEPVLTQTSEQAPSSAPRDVQA-----RMLSSTTILVQWKEPEEPNGQIQGYRVYYT 456
Query: 375 LRPNGRVK--VQGGGGSLVITQIGL---QDAGYYQCVAENSAGMACAAASLAVVVREGLP 429
+ P V ++ IT IG Q + +A S G ++ + V+ + G+P
Sbjct: 457 MDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVP 516
Query: 430 SAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQ 489
P A P S +++L++W P S+ I + L Y+ ++ E Q T +
Sbjct: 517 GQPLNFKAEPESETSILLSWTPPR--SDTIANYELVYKDG---EHGEEQRITIEPGTSYR 571
Query: 490 VRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQ-LSLSSPNPSDIRVAWL 548
++ L+PN+ Y F + A S G ++ T+ PSA PQ +S +SP+ + I V+W
Sbjct: 572 LQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQ 631
Query: 549 PLPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRG---NETQLMLNSLQPNKVYRVRISAGT 605
P P NG + +Y I+Y + E+ G + T+ +L L+ YR+ ++A T
Sbjct: 632 PPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHT 691
Query: 606 AAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQA-KMESLVVSWQPP---PHPTQISGY 661
G G S + RT N+ P +++V+A S+ VSW+ P QI GY
Sbjct: 692 DVGPGPESLSVLIRT----NEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGY 747
Query: 662 KLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFN 721
++++ + NG+ P G+ DV + + ++ L P Y + + A+
Sbjct: 748 QVHYVRM-----ENGE--PKGQ-PMLKDV----MLADAQDMIISGLQPETSYSLTVTAYT 795
Query: 722 KHEDGYAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIV 781
DG + K + P P H + N++ ++W P T +
Sbjct: 796 TKGDGARSKPKLVSTTGAVPGKPRL-------VINHTQMNTAL---IQWHPPVDTFGPLQ 845
Query: 782 NYTVRFSPWGLRNASLVTYYTSSGEDILIG-GLKPFTKYEFAVQSHGVDMDGPFGSVVER 840
Y ++F + L T S ED + Y F + + G +V+
Sbjct: 846 GYRLKFGRKDME--PLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGE--EMVKE 901
Query: 841 STLPDR-PSTPPSDLRLSPLTPSTVRLHWCPPT--EPNGEIVEYLILYSSNHTQPEHQWT 897
++P+ P+ P +L T ++V+L W PP E NG I +Y +LY +
Sbjct: 902 ISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIP------ 955
Query: 898 LLTTQGNIFSAE----VHGLESDTRYFFKMGARTEVGPGPFS 935
LL + I A+ + GL+ DT Y K+ A T GPGP+S
Sbjct: 956 LLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYS 997
Score = 139 bits (350), Expect = 2e-32
Identities = 127/545 (23%), Positives = 230/545 (42%), Gaps = 61/545 (11%)
Query: 402 YYQCVAENSAGMACAAASLAVVVREGLPSAPTR-VTATPLSSSAVLVAWERPEMHSEQ-- 458
Y++ A + G+ + A ++ + PSAP + ++ T SS+++LV+W+ P + +
Sbjct: 582 YFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGI 641
Query: 459 IIGFSLHYQKARGMDNVEYQF-AVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTP 517
I +S+ Y G D+ ++ + +DTT+ + LE T+Y V A++ +G S
Sbjct: 642 ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLS 701
Query: 518 ALVHTLDDVPSAAPQ-LSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEY-----GLGKE 571
L+ T +DVPS P+ + + + N + ++V+W P+ +GQ+ Y++ Y G K
Sbjct: 702 VLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKG 761
Query: 572 DQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPF 631
+ + + ++++ LQP Y + ++A T G GA S + + VP
Sbjct: 762 QPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARS-----KPKLVSTTGAVPG 816
Query: 632 APAELKVQAKMESLVVSWQPPPHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVG 691
P + +M + ++ W PP V G RL GR D +
Sbjct: 817 KPRLVINHTQMNTALIQWHPP---------------VDTFGPLQGYRLKFGRKDME-PLT 860
Query: 692 PVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQRGPPL 751
+ +K + T + G Y +L A NK G V K P + P
Sbjct: 861 TLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMV---KEISIP------EEVPTG 911
Query: 752 PPAHVHAESNSSTSIWLRWKKPDFTTVK--IVNYTVRFSPWGLRNASLVTYYTSSGEDIL 809
P ++H+E +STS+ L W+ P I YT+ + + + + +
Sbjct: 912 FPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMT 971
Query: 810 IGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRLSPLTPSTVRLHWC 869
+ GLKP T Y+ V++H GP+ V+ TLP + + + ++V L W
Sbjct: 972 LTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLP-VDQVFAKNFHVKAVMKTSVLLSWE 1030
Query: 870 PPTEPNGEIVEYLILYSSN----------------HTQPEHQWT-LLTTQGNIFSAEVHG 912
P N + + ILY + +PE ++ +LT +GN H
Sbjct: 1031 IPENYN-SAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHR 1089
Query: 913 LESDT 917
+ + T
Sbjct: 1090 VTAKT 1094
Score = 94.7 bits (234), Expect = 5e-19
Identities = 140/637 (21%), Positives = 251/637 (39%), Gaps = 73/637 (11%)
Query: 335 PAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVKV----QGGGGSL 390
P T+ P + A F+C+A+G+PRP + W G + N R +V G G L
Sbjct: 24 PRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVS-NQRFEVIEFDDGSGSVL 82
Query: 391 VITQIGL-QDAGYYQCVAENSAGMACAAASLAVVVREGLPSA-PT-------RVTATPLS 441
I + +D Y+CVA N+ G + L V+ + +P PT +V +
Sbjct: 83 RIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRT 142
Query: 442 SSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTE----LQVRDLEPNT 497
++ + A P+ F L + ++ + + T LQ+ E +
Sbjct: 143 ATMLCAASGNPDPEITWFKDF-LPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESD 201
Query: 498 DYEFYVVAYSQLGASRTSTPA--LVHTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLS 555
++ VA + G +R S PA V L +V P+ S+ P +I ++
Sbjct: 202 QGKYECVATNSAG-TRYSAPANLYVRELREVRRVPPRFSIP-PTNHEIMPGGSVNITCVA 259
Query: 556 NGQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQW 615
G + Y +++ LG ED ++ L LN ++ + Y ++ T A +Q
Sbjct: 260 VGSPMPY-VKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTC-VAMSTLGVIEAIAQI 317
Query: 616 MHHRTPSMHNQSHVPFAPAELKVQAKMESLVVSWQPPPHPTQISGYKLYWREVGAEE--- 672
P P P + ++ S+ ++W +P +S Y + + +EE
Sbjct: 318 TVKALPKP------PGTP--VVTESTATSITLTWDSG-NPEPVSYYIIQHKPKNSEELYK 368
Query: 673 EANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWK 732
E +G +Y + L P YE ++VA N + +
Sbjct: 369 EIDG--------------------VATTRYSVAGLSPYSDYEFRVVAVNN-------IGR 401
Query: 733 GKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRFSPWGL 792
G + P ++ P P V A SST+I ++WK+P+ +I Y V ++
Sbjct: 402 GPPSE-PVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPT 460
Query: 793 RNAS-LVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPP 851
++ + + + + + IG L P Y V + DGP S ++ T P P
Sbjct: 461 QHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP- 519
Query: 852 SDLRLSPLTPSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVH 911
+ + P + +++ L W PP I Y ++Y E + T+ S +
Sbjct: 520 LNFKAEPESETSILLSWTPPRSDT--IANYELVYKDGEHGEEQRITIEPGT----SYRLQ 573
Query: 912 GLESDTRYFFKMGARTEVGPGPFSRLQDVITLQEKLS 948
GL+ ++ Y+F++ AR+ G G + T+Q K S
Sbjct: 574 GLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPS 610
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 176 bits (446), Expect = 1e-43
Identities = 217/850 (25%), Positives = 346/850 (40%), Gaps = 108/850 (12%)
Query: 145 FSLHPESQTVEENGTARFECHIEGLPAPIITWEKDQVTLPEEP-RLIVLPNGVLQILDVQ 203
F+ P QT G A F C G P P I W K + + +I +G +L +Q
Sbjct: 26 FTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQ 85
Query: 204 E----SDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQ 259
D Y CVA+N+ + S L+V + RG + + P+ V +
Sbjct: 86 PLRTPRDEAIYECVASNNVGE-ISVSTRLTVLREDQIP--RGFPTIDMG-PQLKVVERTR 141
Query: 260 SVVMECVASADPTPFVSWVRQDGKPISTD-----------VIVLG---RTNLLIANAQPW 305
+ M C AS +P P ++W + D P+ T + G R L I ++
Sbjct: 142 TATMLCAASGNPDPEITWFK-DFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEES 200
Query: 306 HSGVYVCRA-NKPRTRDFATAAAELRVL-----AAPAITQAPEALSRTRASTARFVCRAS 359
G Y C A N TR A A +R L P + P + C A
Sbjct: 201 DQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAV 260
Query: 360 GEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAAAS 419
G P P ++W+ L P + + G V+ ++ + Y CVA ++ G+ A A
Sbjct: 261 GSPMPYVKWMLGAEDLTPEDDMPI----GRNVLELNDVRQSANYTCVAMSTLGVIEAIAQ 316
Query: 420 LAVVVREGLPSAPTRVTATPLSSSAVLVAWE--RPEMHSEQIIGFSLHYQKARGMDNVEY 477
+ V + LP P T +++++ + W+ PE S II K + + + Y
Sbjct: 317 ITV---KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYII-----QHKPKNSEEL-Y 367
Query: 478 QFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQ-LSLS 536
+ TT V L P +DYEF VVA + +G S P L T + PS+AP+ +
Sbjct: 368 KEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQAR 427
Query: 537 SPNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGN--ETQL-MLNSLQP 593
+ + I V W P NGQ+ Y++ Y + + + ++ N ++Q+ + +L P
Sbjct: 428 MLSSTTILVQW--KEPEEPNGQIQGYRVYYTMDPTQHV-NNWMKHNVADSQITTIGNLVP 484
Query: 594 NKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQAKME-SLVVSWQPP 652
K Y V++ A T+ G G S + T Q+ VP P K + + E S+++SW PP
Sbjct: 485 QKTYSVKVLAFTSIGDGPLSSDIQVIT-----QTGVPGQPLNFKAEPESETSILLSWTPP 539
Query: 653 PHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRL 712
T I+ Y+L +++ EE PG Y L L P L
Sbjct: 540 RSDT-IANYELVYKDGEHGEEQRITIEPG------------------TSYRLQGLKPNSL 580
Query: 713 YEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKK 772
Y +L A + G A T + A M Q P PP + S SSTSI + W+
Sbjct: 581 YYFRLAA--RSPQGLGA----STAEISARTM--QSKPSAPPQDISCTSPSSTSILVSWQP 632
Query: 773 PDFTTVK--IVNYTVRFSPWGLRN--ASLVTYYTSSGEDILIGGLKPFTKYEFAVQSHGV 828
P I Y+++++ + + S L+ L+ +T+Y V +H
Sbjct: 633 PPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTD 692
Query: 829 DMDGPFGSVVERSTLPDRPSTPPSDLRLSPLTPSTVRLHWCP--PTEPNGEIVEYLILY- 885
GP V T D PS PP + + + ++V++ W P + +G+I Y + Y
Sbjct: 693 VGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYV 752
Query: 886 ----SSNHTQP--------EHQWTL-LTTQGNIFSAEVHGLESDTRYFFKMGARTEVGPG 932
QP + QW TT+ ++ + GL+ +T Y + A T G G
Sbjct: 753 RMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMI---ISGLQPETSYSLTVTAYTTKGDG 809
Query: 933 PFSRLQDVIT 942
S+ + V T
Sbjct: 810 ARSKPKLVST 819
Score = 154 bits (389), Expect = 5e-37
Identities = 220/943 (23%), Positives = 376/943 (39%), Gaps = 113/943 (11%)
Query: 40 VGPLQVILGPEQAAVLNCSLGAAAAGPPTRVTWSKDG---DTLLEHDHLHLLPNGSLW-- 94
+GP ++ + A + C AA+ P +TW KD DT + + L + S+
Sbjct: 130 MGPQLKVVERTRTATMLC---AASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGT 186
Query: 95 -LSQPLAPNGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLAD-------FS 146
+ L S+ES +G Y C+A G S A + + L + FS
Sbjct: 187 PIRGALQIEQSEESD-------QGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFS 239
Query: 147 LHPESQTVEENGTARFECHIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESD 206
+ P + + G+ C G P P + W L E + + N VL++ DV++S
Sbjct: 240 IPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRN-VLELNDVRQS- 297
Query: 207 AGPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECV 266
Y CVA ++ G + + V + P T VV+ + +
Sbjct: 298 -ANYTCVAMSTL---------------GVIEAIAQITVKALPKPPGTPVVTESTATSITL 341
Query: 267 A--SADPTPFVSWVRQ----DGKPISTDVIVLGRTNLLIANAQPWHSGVY-VCRANK--- 316
S +P P ++ Q + + + ++ + T +A P+ + V N
Sbjct: 342 TWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGR 401
Query: 317 -PRTRDFATAAAELRVLAAPAITQAPEALSRTRASTARFV-CRASGEPRPALRWLHNGAP 374
P + T +E +AP QA R +ST V + EP ++
Sbjct: 402 GPPSEPVLTQTSEQAPSSAPRDVQA-----RMLSSTTILVQWKEPEEPNGQIQGYRVYYT 456
Query: 375 LRPNGRVK--VQGGGGSLVITQIGL---QDAGYYQCVAENSAGMACAAASLAVVVREGLP 429
+ P V ++ IT IG Q + +A S G ++ + V+ + G+P
Sbjct: 457 MDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVP 516
Query: 430 SAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQ 489
P A P S +++L++W P S+ I + L Y+ ++ E Q T +
Sbjct: 517 GQPLNFKAEPESETSILLSWTPPR--SDTIANYELVYKDG---EHGEEQRITIEPGTSYR 571
Query: 490 VRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQ-LSLSSPNPSDIRVAWL 548
++ L+PN+ Y F + A S G ++ T+ PSA PQ +S +SP+ + I V+W
Sbjct: 572 LQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQ 631
Query: 549 PLPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRG---NETQLMLNSLQPNKVYRVRISAGT 605
P P NG + +Y I+Y + E+ G + T+ +L L+ YR+ ++A T
Sbjct: 632 PPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHT 691
Query: 606 AAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQA-KMESLVVSWQPP---PHPTQISGY 661
G G S + RT N+ P +++V+A S+ VSW+ P QI GY
Sbjct: 692 DVGPGPESLSVLIRT----NEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGY 747
Query: 662 KLYWREVGAEEEANGDRLPGGR-GDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAF 720
++++ + E L D W+ + ++ L P Y + + A+
Sbjct: 748 QVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMI----ISGLQPETSYSLTVTAY 803
Query: 721 NKHEDGYAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKI 780
DG + K + P P H + N++ ++W P T +
Sbjct: 804 TTKGDGARSKPKLVSTTGAVPGKPRL-------VINHTQMNTAL---IQWHPPVDTFGPL 853
Query: 781 VNYTVRFSPWGLRNASLVTYYTSSGEDILIG-GLKPFTKYEFAVQSHGVDMDGPFGSVVE 839
Y ++F + L T S ED + Y F + + G +V+
Sbjct: 854 QGYRLKFGRKDME--PLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGE--EMVK 909
Query: 840 RSTLPDR-PSTPPSDLRLSPLTPSTVRLHWCPPT--EPNGEIVEYLILYSSNHTQPEHQW 896
++P+ P+ P +L T ++V+L W PP E NG I +Y +LY +
Sbjct: 910 EISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIP----- 964
Query: 897 TLLTTQGNIFSAE----VHGLESDTRYFFKMGARTEVGPGPFS 935
LL + I A+ + GL+ DT Y K+ A T GPGP+S
Sbjct: 965 -LLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYS 1006
Score = 133 bits (335), Expect = 9e-31
Identities = 127/554 (22%), Positives = 233/554 (42%), Gaps = 70/554 (12%)
Query: 402 YYQCVAENSAGMACAAASLAVVVREGLPSAPTR-VTATPLSSSAVLVAWERPEMHSEQ-- 458
Y++ A + G+ + A ++ + PSAP + ++ T SS+++LV+W+ P + +
Sbjct: 582 YFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGI 641
Query: 459 IIGFSLHYQKARGMDNVEYQF-AVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTP 517
I +S+ Y G D+ ++ + +DTT+ + LE T+Y V A++ +G S
Sbjct: 642 ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLS 701
Query: 518 ALVHTLDDVPSAAPQ-LSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEY---------- 566
L+ T +DVPS P+ + + + N + ++V+W P+ +GQ+ Y++ Y
Sbjct: 702 VLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKG 761
Query: 567 -GLGKEDQIFSTEVRGNET---QLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPS 622
+ K+ + + ++T ++++ LQP Y + ++A T G GA S +
Sbjct: 762 QPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARS-----KPKL 816
Query: 623 MHNQSHVPFAPAELKVQAKMESLVVSWQPPPHPTQISGYKLYWREVGAEEEANGDRLPGG 682
+ VP P + +M + ++ W PP V G RL G
Sbjct: 817 VSTTGAVPGKPRLVINHTQMNTALIQWHPP---------------VDTFGPLQGYRLKFG 861
Query: 683 RGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPD 742
R D + + +K + T + G Y +L A NK G V K P
Sbjct: 862 RKDME-PLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMV---KEISIP--- 914
Query: 743 MPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVK--IVNYTVRFSPWGLRNASLVTY 800
+ P P ++H+E +STS+ L W+ P I YT+ + + +
Sbjct: 915 ---EEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQL 971
Query: 801 YTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRLSPLT 860
+ + + GLKP T Y+ V++H GP+ V+ TLP + + +
Sbjct: 972 IVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLP-VDQVFAKNFHVKAVM 1030
Query: 861 PSTVRLHWCPPTEPNGEIVEYLILYSSN----------------HTQPEHQWT-LLTTQG 903
++V L W P N + + ILY + +PE ++ +LT +G
Sbjct: 1031 KTSVLLSWEIPENYN-SAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRG 1089
Query: 904 NIFSAEVHGLESDT 917
N H + + T
Sbjct: 1090 NSAGGLQHRVTAKT 1103
Score = 94.7 bits (234), Expect = 5e-19
Identities = 140/637 (21%), Positives = 251/637 (39%), Gaps = 73/637 (11%)
Query: 335 PAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVKV----QGGGGSL 390
P T+ P + A F+C+A+G+PRP + W G + N R +V G G L
Sbjct: 24 PRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVS-NQRFEVIEFDDGSGSVL 82
Query: 391 VITQIGL-QDAGYYQCVAENSAGMACAAASLAVVVREGLPSA-PT-------RVTATPLS 441
I + +D Y+CVA N+ G + L V+ + +P PT +V +
Sbjct: 83 RIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRT 142
Query: 442 SSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTE----LQVRDLEPNT 497
++ + A P+ F L + ++ + + T LQ+ E +
Sbjct: 143 ATMLCAASGNPDPEITWFKDF-LPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESD 201
Query: 498 DYEFYVVAYSQLGASRTSTPA--LVHTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLS 555
++ VA + G +R S PA V L +V P+ S+ P +I ++
Sbjct: 202 QGKYECVATNSAG-TRYSAPANLYVRELREVRRVPPRFSIP-PTNHEIMPGGSVNITCVA 259
Query: 556 NGQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQW 615
G + Y +++ LG ED ++ L LN ++ + Y ++ T A +Q
Sbjct: 260 VGSPMPY-VKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTC-VAMSTLGVIEAIAQI 317
Query: 616 MHHRTPSMHNQSHVPFAPAELKVQAKMESLVVSWQPPPHPTQISGYKLYWREVGAEE--- 672
P P P + ++ S+ ++W +P +S Y + + +EE
Sbjct: 318 TVKALPKP------PGTP--VVTESTATSITLTWDSG-NPEPVSYYIIQHKPKNSEELYK 368
Query: 673 EANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWK 732
E +G +Y + L P YE ++VA N + +
Sbjct: 369 EIDG--------------------VATTRYSVAGLSPYSDYEFRVVAVNN-------IGR 401
Query: 733 GKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRFSPWGL 792
G + P ++ P P V A SST+I ++WK+P+ +I Y V ++
Sbjct: 402 GPPSE-PVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPT 460
Query: 793 RNAS-LVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPP 851
++ + + + + + IG L P Y V + DGP S ++ T P P
Sbjct: 461 QHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP- 519
Query: 852 SDLRLSPLTPSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVH 911
+ + P + +++ L W PP I Y ++Y E + T+ S +
Sbjct: 520 LNFKAEPESETSILLSWTPPRSDT--IANYELVYKDGEHGEEQRITIEPGT----SYRLQ 573
Query: 912 GLESDTRYFFKMGARTEVGPGPFSRLQDVITLQEKLS 948
GL+ ++ Y+F++ AR+ G G + T+Q K S
Sbjct: 574 GLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPS 610
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 169 bits (427), Expect = 2e-41
Identities = 205/845 (24%), Positives = 318/845 (37%), Gaps = 130/845 (15%)
Query: 42 PLQVILGPEQAAVLNCSLGAAAAGPPT-RVTWSKDGDTLLE-----HDHLHLLPNGSLWL 95
P VI+ + LNC A G PT + W KDG+ + H LLP+GSL+
Sbjct: 53 PSDVIVSKGEPTTLNCK----AEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFF 108
Query: 96 SQPLAPNGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLAD-FSLHPESQTV 154
+ + S EG+Y C+A LG S+ A +++A L D F +P V
Sbjct: 109 LRIVHGRRSKPD--------EGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVV 160
Query: 155 EENGTARFECHI-EGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCV 213
A EC G P P I W+KD+V + ++ I + G L I + ++SDAG Y CV
Sbjct: 161 AAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCV 220
Query: 214 ATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTP 273
TN + S A L+V R + + P N V+ ++V C DP P
Sbjct: 221 GTNMVGERDSDPAELTVFERPT----------FLRRPINQVVLEEEAVEFRCQVQGDPQP 270
Query: 274 FVSWVRQDGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLA 333
V W + D + L I G Y+C A + A+A L V A
Sbjct: 271 TVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGK--MEASATLTVRA 328
Query: 334 APAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGA--------PLRPNGRVKVQG 385
P P + T F C G P+PA+ W G+ P +PN R V
Sbjct: 329 PPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSV-S 387
Query: 386 GGGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAV----------VVREGLPSAPTRV 435
G L IT I DAGYY C A AG A A L V ++ +G + V
Sbjct: 388 PTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAV 447
Query: 436 TATPL------SSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQ 489
T L +++W + GF+ + R A + LQ
Sbjct: 448 DGTALLKCKATGDPLPVISWLKE--------GFTFPGRDPR---------ATIQEQGTLQ 490
Query: 490 VRDLEPNTDYEFYVVAYSQLGASRTS----------TPALVHTLDDVPSAAPQLSLSSPN 539
+++L + + VA S G + S T + + L D+P + ++
Sbjct: 491 IKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVT 550
Query: 540 PSDIRVAWLP-LPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYR 598
+ + ++W P P +L + + Q + V+ T + L+PN +Y
Sbjct: 551 KNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVK--TTLYTVRGLRPNTIYL 608
Query: 599 VRISAGTAAGFGAPSQWMHH-RTPSM--------HNQSHVPFAPAELKVQAKM----ESL 645
+ A G PS RT + H Q +++ + ++
Sbjct: 609 FMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTV 668
Query: 646 VVSWQPPPHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELT 705
V+W P I GY++ +R+ G + +W ++ + + L
Sbjct: 669 QVTWTVDRQPQFIQGYRVMYRQTS-----------GLQATSSWQNLDAKVPTE-RSAVLV 716
Query: 706 QLVPGRLYEVKLVAFNKHEDGYAAVWK--GKTEKAPAPDMPIQRGPPLPPAHVHAESNSS 763
L G YE+K+ + G + K TE+AP+ PP + S +S
Sbjct: 717 NLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPS-------APPQSVTVLTVGSYNS 769
Query: 764 TSIWLRW--KKPDFTTVKIVNYTVRFSPWGLRNAS---LVTYYTSSGEDILIGGLKPFTK 818
TSI + W PD I Y + W L N + + ++ ++IGGL P +
Sbjct: 770 TSISVSWDPPPPDHQNGIIQEYKI----WCLGNETRFHINKTVDAAIRSVIIGGLFPGIQ 825
Query: 819 YEFAV 823
Y V
Sbjct: 826 YRVEV 830
Score = 101 bits (252), Expect = 4e-21
Identities = 217/962 (22%), Positives = 345/962 (35%), Gaps = 171/962 (17%)
Query: 148 HPESQTVEENGTARFECHIEGLPAPIITWEKDQV---TLPEEPRL--IVLPNGVLQILDV 202
HP V + C EG P P I W KD T ++PR ++LP+G L L +
Sbjct: 52 HPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRI 111
Query: 203 -----QESDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVS 257
+ D G Y CVA N + S+ A L VA DVV+ A
Sbjct: 112 VHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAA--------- 162
Query: 258 GQSVVMECVAS-ADPTPFVSW----VRQDGKPISTDVIVLGRTNLLIANAQPWHSGVYVC 312
G+ ++EC P P + W VR D K + I + L+I+N + +G+Y C
Sbjct: 163 GEPAILECQPPRGHPEPTIYWKKDKVRIDDKE---ERISIRGGKLMISNTRKSDAGMYTC 219
Query: 313 -RANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHN 371
N RD + AEL V P + P F C+ G+P+P +RW +
Sbjct: 220 VGTNMVGERD--SDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKD 277
Query: 372 GAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAEN-------SAGMACAAASLAVVV 424
A L P GR ++ +L I + D G Y C+AEN SA + A VV
Sbjct: 278 DADL-PRGRYDIKDDY-TLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVR 335
Query: 425 REGLPSAPTRVTATPLSSSA---VLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAV 481
A R P + V W++ Q + F Q+ +V
Sbjct: 336 PRDQIVAQGRTVTFPCETKGNPQPAVFWQK---EGSQNLLFPNQPQQPNSRCSV------ 386
Query: 482 NNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSSPNPS 541
+ T +L + +++ +D +Y+ + S + L T D + P + L P
Sbjct: 387 -SPTGDLTITNIQ-RSDAGYYICQALTVAGSILAKAQLEVT-DVLTDRPPPIILQGPANQ 443
Query: 542 DIRVAWLPLPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRI 601
+ V L + G + KE F G + + + ++ +RI
Sbjct: 444 TLAVDGTALLKCKATGDPLPV---ISWLKEGFTFP----GRDPRATIQEQGTLQIKNLRI 496
Query: 602 S-AGT----AAGFGAPSQWMH--------HRTPSMHNQSHVPFAPAELKV-QAKMESLVV 647
S GT A + W ++ S +P P++ +V S+ +
Sbjct: 497 SDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTL 556
Query: 648 SWQP-PPHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQ 706
SWQP P S Y + E ++ +N +W V K Y +
Sbjct: 557 SWQPGTPGTLPASAYII---EAFSQSVSN-----------SWQT--VANHVKTTLYTVRG 600
Query: 707 LVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQRGPPLPPA----HVHAESN- 761
L P +Y + A N +G ++ +P D P++ PPA H +
Sbjct: 601 LRPNTIYLFMVRAINP---------QGLSDPSPMSD-PVRTQDISPPAQGVDHRQVQKEL 650
Query: 762 -------------SSTSIWLRW---KKPDFTTVKIVNYTVRF---------SPWGLRNAS 796
+ T++ + W ++P F I Y V + S W +A
Sbjct: 651 GDVLVRLHNPVVLTPTTVQVTWTVDRQPQF----IQGYRVMYRQTSGLQATSSWQNLDAK 706
Query: 797 LVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSD--- 853
+ T ++ ++ LK YE V+ + + G T + PS PP
Sbjct: 707 VPTERSA-----VLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTV 761
Query: 854 LRLSPLTPSTVRLHWCPPT--EPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVH 911
L + +++ + W PP NG I EY I N T+ T I S +
Sbjct: 762 LTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHIN---KTVDAAIRSVIIG 818
Query: 912 GLESDTRYFFKMGARTEVGPGPFSRLQDVI--------------TLQEKLSDSLDMHSVT 957
GL +Y ++ A T G G S Q +I ++ E+++D + +
Sbjct: 819 GLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDVVKQPAFI 878
Query: 958 GIIVGVCLGLLCLLACMCAGLRRSPHRESLPGLSSTATPGNPALYSRA------RLGPPS 1011
I G C +L + R+ R+ L + T G+ L S G PS
Sbjct: 879 AGIGGACWVILMGFSIWLYWRRKK--RKGLSNYAVTFQRGDGGLMSNGSRPGLLNAGDPS 936
Query: 1012 PP 1013
P
Sbjct: 937 YP 938
Score = 50.4 bits (119), Expect = 1e-05
Identities = 44/180 (24%), Positives = 68/180 (37%), Gaps = 15/180 (8%)
Query: 246 IVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTDVIVLGRTNLLIANAQPW 305
IV P + V G+ + C A PTP + W + DG+ + TD +L+ + +
Sbjct: 49 IVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYK-DGERVETDKDDPRSHRMLLPSGSLF 107
Query: 306 HSGVYVCRANKPRTRDFATAA-----------AELRV-LAAPAITQAPEALSRTRASTAR 353
+ R +KP + A A L V L Q P + A
Sbjct: 108 FLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAI 167
Query: 354 FVCR-ASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAG 412
C+ G P P + W + + + ++ GG L+I+ DAG Y CV N G
Sbjct: 168 LECQPPRGHPEPTIYWKKDKVRI-DDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVG 226
Score = 37.7 bits (86), Expect = 0.069
Identities = 35/137 (25%), Positives = 55/137 (40%), Gaps = 13/137 (9%)
Query: 335 PAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPN----GRVKVQGGGGSL 390
P I + P + ++ C+A G P P + W +G + + ++ GSL
Sbjct: 47 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 106
Query: 391 VITQI-----GLQDAGYYQCVAENSAGMACAA-ASLAV-VVREGLPSAPTRVTATPLSSS 443
+I D G Y CVA N G A + ASL V ++R+ PT V +
Sbjct: 107 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVA--AGE 164
Query: 444 AVLVAWERPEMHSEQII 460
++ + P H E I
Sbjct: 165 PAILECQPPRGHPEPTI 181
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 169 bits (427), Expect = 2e-41
Identities = 205/845 (24%), Positives = 318/845 (37%), Gaps = 130/845 (15%)
Query: 42 PLQVILGPEQAAVLNCSLGAAAAGPPT-RVTWSKDGDTLLE-----HDHLHLLPNGSLWL 95
P VI+ + LNC A G PT + W KDG+ + H LLP+GSL+
Sbjct: 37 PSDVIVSKGEPTTLNCK----AEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFF 92
Query: 96 SQPLAPNGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLAD-FSLHPESQTV 154
+ + S EG+Y C+A LG S+ A +++A L D F +P V
Sbjct: 93 LRIVHGRRSKPD--------EGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVV 144
Query: 155 EENGTARFECHI-EGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCV 213
A EC G P P I W+KD+V + ++ I + G L I + ++SDAG Y CV
Sbjct: 145 AAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCV 204
Query: 214 ATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTP 273
TN + S A L+V R + + P N V+ ++V C DP P
Sbjct: 205 GTNMVGERDSDPAELTVFERPT----------FLRRPINQVVLEEEAVEFRCQVQGDPQP 254
Query: 274 FVSWVRQDGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLA 333
V W + D + L I G Y+C A + A+A L V A
Sbjct: 255 TVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGK--MEASATLTVRA 312
Query: 334 APAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGA--------PLRPNGRVKVQG 385
P P + T F C G P+PA+ W G+ P +PN R V
Sbjct: 313 PPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSV-S 371
Query: 386 GGGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAV----------VVREGLPSAPTRV 435
G L IT I DAGYY C A AG A A L V ++ +G + V
Sbjct: 372 PTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAV 431
Query: 436 TATPL------SSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQ 489
T L +++W + GF+ + R A + LQ
Sbjct: 432 DGTALLKCKATGDPLPVISWLKE--------GFTFPGRDPR---------ATIQEQGTLQ 474
Query: 490 VRDLEPNTDYEFYVVAYSQLGASRTS----------TPALVHTLDDVPSAAPQLSLSSPN 539
+++L + + VA S G + S T + + L D+P + ++
Sbjct: 475 IKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVT 534
Query: 540 PSDIRVAWLP-LPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYR 598
+ + ++W P P +L + + Q + V+ T + L+PN +Y
Sbjct: 535 KNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVK--TTLYTVRGLRPNTIYL 592
Query: 599 VRISAGTAAGFGAPSQWMHH-RTPSM--------HNQSHVPFAPAELKVQAKM----ESL 645
+ A G PS RT + H Q +++ + ++
Sbjct: 593 FMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTV 652
Query: 646 VVSWQPPPHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELT 705
V+W P I GY++ +R+ G + +W ++ + + L
Sbjct: 653 QVTWTVDRQPQFIQGYRVMYRQTS-----------GLQATSSWQNLDAKVPTE-RSAVLV 700
Query: 706 QLVPGRLYEVKLVAFNKHEDGYAAVWK--GKTEKAPAPDMPIQRGPPLPPAHVHAESNSS 763
L G YE+K+ + G + K TE+AP+ PP + S +S
Sbjct: 701 NLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPS-------APPQSVTVLTVGSYNS 753
Query: 764 TSIWLRW--KKPDFTTVKIVNYTVRFSPWGLRNAS---LVTYYTSSGEDILIGGLKPFTK 818
TSI + W PD I Y + W L N + + ++ ++IGGL P +
Sbjct: 754 TSISVSWDPPPPDHQNGIIQEYKI----WCLGNETRFHINKTVDAAIRSVIIGGLFPGIQ 809
Query: 819 YEFAV 823
Y V
Sbjct: 810 YRVEV 814
Score = 101 bits (252), Expect = 4e-21
Identities = 217/962 (22%), Positives = 345/962 (35%), Gaps = 171/962 (17%)
Query: 148 HPESQTVEENGTARFECHIEGLPAPIITWEKDQV---TLPEEPRL--IVLPNGVLQILDV 202
HP V + C EG P P I W KD T ++PR ++LP+G L L +
Sbjct: 36 HPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRI 95
Query: 203 -----QESDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVS 257
+ D G Y CVA N + S+ A L VA DVV+ A
Sbjct: 96 VHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAA--------- 146
Query: 258 GQSVVMECVAS-ADPTPFVSW----VRQDGKPISTDVIVLGRTNLLIANAQPWHSGVYVC 312
G+ ++EC P P + W VR D K + I + L+I+N + +G+Y C
Sbjct: 147 GEPAILECQPPRGHPEPTIYWKKDKVRIDDKE---ERISIRGGKLMISNTRKSDAGMYTC 203
Query: 313 -RANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHN 371
N RD + AEL V P + P F C+ G+P+P +RW +
Sbjct: 204 VGTNMVGERD--SDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKD 261
Query: 372 GAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAEN-------SAGMACAAASLAVVV 424
A L P GR ++ +L I + D G Y C+AEN SA + A VV
Sbjct: 262 DADL-PRGRYDIKDDY-TLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVR 319
Query: 425 REGLPSAPTRVTATPLSSSA---VLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAV 481
A R P + V W++ Q + F Q+ +V
Sbjct: 320 PRDQIVAQGRTVTFPCETKGNPQPAVFWQK---EGSQNLLFPNQPQQPNSRCSV------ 370
Query: 482 NNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSSPNPS 541
+ T +L + +++ +D +Y+ + S + L T D + P + L P
Sbjct: 371 -SPTGDLTITNIQ-RSDAGYYICQALTVAGSILAKAQLEVT-DVLTDRPPPIILQGPANQ 427
Query: 542 DIRVAWLPLPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRI 601
+ V L + G + KE F G + + + ++ +RI
Sbjct: 428 TLAVDGTALLKCKATGDPLPV---ISWLKEGFTFP----GRDPRATIQEQGTLQIKNLRI 480
Query: 602 S-AGT----AAGFGAPSQWMH--------HRTPSMHNQSHVPFAPAELKV-QAKMESLVV 647
S GT A + W ++ S +P P++ +V S+ +
Sbjct: 481 SDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTL 540
Query: 648 SWQP-PPHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQ 706
SWQP P S Y + E ++ +N +W V K Y +
Sbjct: 541 SWQPGTPGTLPASAYII---EAFSQSVSN-----------SWQT--VANHVKTTLYTVRG 584
Query: 707 LVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQRGPPLPPA----HVHAESN- 761
L P +Y + A N +G ++ +P D P++ PPA H +
Sbjct: 585 LRPNTIYLFMVRAINP---------QGLSDPSPMSD-PVRTQDISPPAQGVDHRQVQKEL 634
Query: 762 -------------SSTSIWLRW---KKPDFTTVKIVNYTVRF---------SPWGLRNAS 796
+ T++ + W ++P F I Y V + S W +A
Sbjct: 635 GDVLVRLHNPVVLTPTTVQVTWTVDRQPQF----IQGYRVMYRQTSGLQATSSWQNLDAK 690
Query: 797 LVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSD--- 853
+ T ++ ++ LK YE V+ + + G T + PS PP
Sbjct: 691 VPTERSA-----VLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTV 745
Query: 854 LRLSPLTPSTVRLHWCPPT--EPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVH 911
L + +++ + W PP NG I EY I N T+ T I S +
Sbjct: 746 LTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHIN---KTVDAAIRSVIIG 802
Query: 912 GLESDTRYFFKMGARTEVGPGPFSRLQDVI--------------TLQEKLSDSLDMHSVT 957
GL +Y ++ A T G G S Q +I ++ E+++D + +
Sbjct: 803 GLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDVVKQPAFI 862
Query: 958 GIIVGVCLGLLCLLACMCAGLRRSPHRESLPGLSSTATPGNPALYSRA------RLGPPS 1011
I G C +L + R+ R+ L + T G+ L S G PS
Sbjct: 863 AGIGGACWVILMGFSIWLYWRRKK--RKGLSNYAVTFQRGDGGLMSNGSRPGLLNAGDPS 920
Query: 1012 PP 1013
P
Sbjct: 921 YP 922
Score = 50.4 bits (119), Expect = 1e-05
Identities = 44/180 (24%), Positives = 68/180 (37%), Gaps = 15/180 (8%)
Query: 246 IVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTDVIVLGRTNLLIANAQPW 305
IV P + V G+ + C A PTP + W + DG+ + TD +L+ + +
Sbjct: 33 IVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYK-DGERVETDKDDPRSHRMLLPSGSLF 91
Query: 306 HSGVYVCRANKPRTRDFATAA-----------AELRV-LAAPAITQAPEALSRTRASTAR 353
+ R +KP + A A L V L Q P + A
Sbjct: 92 FLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAI 151
Query: 354 FVCR-ASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAG 412
C+ G P P + W + + + ++ GG L+I+ DAG Y CV N G
Sbjct: 152 LECQPPRGHPEPTIYWKKDKVRI-DDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVG 210
Score = 37.7 bits (86), Expect = 0.069
Identities = 35/137 (25%), Positives = 55/137 (40%), Gaps = 13/137 (9%)
Query: 335 PAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPN----GRVKVQGGGGSL 390
P I + P + ++ C+A G P P + W +G + + ++ GSL
Sbjct: 31 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 90
Query: 391 VITQI-----GLQDAGYYQCVAENSAGMACAA-ASLAV-VVREGLPSAPTRVTATPLSSS 443
+I D G Y CVA N G A + ASL V ++R+ PT V +
Sbjct: 91 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVA--AGE 148
Query: 444 AVLVAWERPEMHSEQII 460
++ + P H E I
Sbjct: 149 PAILECQPPRGHPEPTI 165
>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
Length = 1026
Score = 166 bits (419), Expect = 2e-40
Identities = 202/919 (21%), Positives = 352/919 (38%), Gaps = 91/919 (9%)
Query: 50 EQAAVLNCSLGAAAAGPPTRVTWSKDG-DTLLEHDHLHLLPNGSLWLSQPLAPNGSDESV 108
E+ LNC + P + W +G D D + + GSL ++ P N + ++
Sbjct: 43 EKKVKLNCEV---KGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLINNP---NKTQDA- 95
Query: 109 PEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTARFEC---- 164
G Y C A G + S+ A ++ A L +F S G
Sbjct: 96 --------GTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPP 147
Query: 165 -HIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFS 223
H L I + + + R + G L I V++SD G Y CV TN+ H
Sbjct: 148 PHSGELSYAWIF--NEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNHKV 205
Query: 224 QEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGK 283
+ R + + V PE G +V +EC A +P P + W R DGK
Sbjct: 206 LGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGK 265
Query: 284 PISTDVIVLGRTNLL-IANAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPE 342
PI+ +L I N Q +G+Y C A R ++ A +L A P Q
Sbjct: 266 PIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKN--VARGQLTFYAQPNWIQKIN 323
Query: 343 ALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGY 402
+ + C+A+G P+P +WL NG PL R++++ G +L IT + L DAG
Sbjct: 324 DIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQG--TLNITIVNLSDAGM 381
Query: 403 YQCVAENSAGMACAAASLAVVV--REGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQII 460
YQC+AEN G+ + A L+V+ + + RVT + V+ +P+ + +
Sbjct: 382 YQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIEC--KPKASPKPV- 438
Query: 461 GFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALV 520
++K R + + ++ D L++ ++ + + +A + G + ++ +V
Sbjct: 439 ---YTWKKGRDILKENERITISED-GNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVV 494
Query: 521 HTLDDVPSAAPQLSLSSPNPSDIRVA-WLPLPPSLSNGQVVKYKIEYGLG------KEDQ 573
P + P+ D+ V + LP +++ + + D
Sbjct: 495 KD--------PTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDG 546
Query: 574 IFSTEVRGNET--QLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPF 631
V G ++ LM+ ++Q + T+ + + + R P P
Sbjct: 547 DHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGP--------PG 598
Query: 632 APAELKVQAKMESLV-VSWQP-PPHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWD 689
P + + ++ +SW+P P + + I+ Y + R P G QA
Sbjct: 599 PPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQ------------ARTPFSVGWQAVS 646
Query: 690 VGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQRGP 749
P + K + L P YE + VA N + G+ + + P
Sbjct: 647 TVPELIDGKTFTATVVGLNPWVEYEFRTVAAN-------VIGIGEPSRPSEKRRTEEALP 699
Query: 750 PLPPAHVHAESNSSTSIWLRWK--KPDFTTVKIVNYTVRFSPWGLRNASLVTYYTSSGED 807
+ PA+V S + + + W+ + + Y V F P+G + ++T S+
Sbjct: 700 EVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYG-KMIWMLTVLASADAS 758
Query: 808 ILI---GGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRLSPLTPSTV 864
+ + PF+ +E V +GPF + + P+ PP+ + L+ + +
Sbjct: 759 RYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDI 818
Query: 865 RLHWCPPTEPN-GEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESDTRYFFKM 923
+ W P E N G I Y + Y H E + T GN S ++ L+ Y +
Sbjct: 819 EVFWASPLEKNRGRIQGYEVKY-WRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAV 877
Query: 924 GARTEVGPGPFSRLQDVIT 942
A G GP S +V T
Sbjct: 878 KAYNSAGTGPSSATVNVTT 896
Score = 124 bits (312), Expect = 4e-28
Identities = 194/828 (23%), Positives = 319/828 (38%), Gaps = 116/828 (14%)
Query: 149 PESQTVEENGTARFECHIEGLPAPIITWEK-DQVTLPEEPRLIVLPNGVLQILDVQESDA 207
PE+ + T + EC G P P I W + D + + R NG+L+I + Q+ DA
Sbjct: 232 PETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARRHK-SNGILEIPNFQQEDA 290
Query: 208 GPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVA 267
G Y CVA NS ++ ++ L A + + VA EN V EC A
Sbjct: 291 GLYECVAENSRGKNVARGQLTFYAQPNWIQKIND---IHVAMEEN--------VFWECKA 339
Query: 268 SADPTPFVSWVRQDGKPISTD---VIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFAT 324
+ P P W++ +G+P+ T I G N+ I N +G+Y C A F+
Sbjct: 340 NGRPKPTYKWLK-NGEPLLTRDRIQIEQGTLNITIVNLSD--AGMYQCLAENKHGVIFSN 396
Query: 325 AAAELRVLAAPAITQAPEALSRTRASTARFV---------CRASGEPRPALRWLHNGAPL 375
A EL V+A P+ SRT V C+ P+P W L
Sbjct: 397 A--ELSVIAV-----GPD-FSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDIL 448
Query: 376 RPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAVVVREGLPSAPTRV 435
+ N R+ + G +L I + DAG Y C+A N G A + +L V PTRV
Sbjct: 449 KENERITISEDG-NLRIINVTKSDAGSYTCIATNHFGTASSTGNLVV-------KDPTRV 500
Query: 436 TATPLS-----SSAVLVAWERPEMHSEQII---GFSLHY-QKARGMDNVEYQFAVNNDTT 486
P S ++++ + HS I+ F+ H R D+ E + +
Sbjct: 501 MVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFE-RVGGQDSAG 559
Query: 487 ELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVA 546
+L +R+++ ++ + + + + +V P A +++ + +++
Sbjct: 560 DLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEA---VTIDEITDTTAQLS 616
Query: 547 WLPLPPSLS--NGQVVKYKIEYGLGKEDQIFSTE-VRGNETQLMLNSLQPNKVYRVRISA 603
W P P + S V++ + + +G + E + G + L P Y R A
Sbjct: 617 WRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVA 676
Query: 604 GTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQAKMES-LVVSWQPPPHPTQIS--- 659
G G PS+ R ++ PA + +S LV++W+ P Q
Sbjct: 677 ANVIGIGEPSRPSEKRRTE---EALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGF 733
Query: 660 GYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLV-PGRLYEVKLV 718
GY + +R G W + + + + V P +EVK+
Sbjct: 734 GYVVAFRPYGK---------------MIWMLTVLASADASRYVFRNESVHPFSPFEVKVG 778
Query: 719 AFNKHEDGYAAVWKGKTEKAPAPDM-PIQRGPPLPPAHVHAESNSSTSIWLRWKKP-DFT 776
FN KG+ +P + + P PPA + A S S+T I + W P +
Sbjct: 779 VFNN---------KGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKN 829
Query: 777 TVKIVNYTVRFSPW-------GLRNASLVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVD 829
+I Y V++ W R V TS+ I LK Y AV+++
Sbjct: 830 RGRIQGYEVKY--WRHEDKEENARKIRTVGNQTSTK----ITNLKGSVLYHLAVKAYNSA 883
Query: 830 MDGPFGSVVERSTLPDRPSTPPSDLRLSPLTPSTVRLHW--CPPTEPNGEIVEYLILYSS 887
GP + V +T PS PP ++ + + S + L+W + E+ Y +LY
Sbjct: 884 GTGPSSATVNVTTRKPPPSQPPGNI-IWNSSDSKIILNWDQVKALDNESEVKGYKVLYRW 942
Query: 888 NHTQPEHQWTLLTTQGNIFSAEVHGLESDTRYFFKMGARTEVGPGPFS 935
N Q + + N S E+ L D Y ++ ++ G G S
Sbjct: 943 N-----RQSSTSVIETNKTSVEL-SLPFDEDYIIEIKPFSDGGDGSSS 984
Score = 77.8 bits (190), Expect = 6e-14
Identities = 88/339 (25%), Positives = 133/339 (39%), Gaps = 57/339 (16%)
Query: 108 VPEAVGVIEGNYSCLA-----HGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTARF 162
+P + V++ CLA HGP+ + + F L E + V+ N
Sbjct: 3 LPWELLVLQSFILCLADDSTLHGPIFIQEPSPVM--------FPLDSEEKKVKLN----- 49
Query: 163 ECHIEGLPAPIITWEKD--QVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQ 220
C ++G P P I W+ + V + R V+ +L + DAG Y+C ATNS
Sbjct: 50 -CEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFGT 108
Query: 221 HFSQEALLSVAH--------RGSLASTRGQDVVIVAA-PENTTVVSGQSVVMECVASADP 271
S+EA L A+ R +++ RGQ +V++ P ++ +S + E + D
Sbjct: 109 IVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDN 168
Query: 272 TPFVSWVRQDGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRV 331
FVS ++ G NL IA + G Y C T +
Sbjct: 169 RRFVS--QETG-------------NLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLI 213
Query: 332 LAAPAI---------TQAPEALSRTRASTARFVCRASGEPRPALRWLH-NGAPLRPNGRV 381
L + Q PE + + +T + C A G P P + W +G P+ R
Sbjct: 214 LRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKAR- 272
Query: 382 KVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAAASL 420
G L I +DAG Y+CVAENS G A L
Sbjct: 273 -RHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQL 310
Score = 43.1 bits (100), Expect = 0.002
Identities = 48/232 (20%), Positives = 89/232 (38%), Gaps = 7/232 (3%)
Query: 722 KHEDGYAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKK-PDF---TT 777
KH Y + + ++ A I RGPP PP V + + T+ L W+ PD T
Sbjct: 569 KHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPIT 628
Query: 778 VKIVNYTVRFSPWGLRNASLVTYYTSSGEDILIGGLKPFTKYEF-AVQSHGVDMDGPFGS 836
+ ++ FS +++ + GL P+ +YEF V ++ + + P
Sbjct: 629 MYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRP 688
Query: 837 VVERSTLPDRPSTPPSDLRLSPLTPSTVRLHW--CPPTEPNGEIVEYLILYSSNHTQPEH 894
+R T P P+++ + S + + W P NG Y++ +
Sbjct: 689 SEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWM 748
Query: 895 QWTLLTTQGNIFSAEVHGLESDTRYFFKMGARTEVGPGPFSRLQDVITLQEK 946
L + + + + + + K+G G GPFS V + +E+
Sbjct: 749 LTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEE 800
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 165 bits (418), Expect = 2e-40
Identities = 202/785 (25%), Positives = 303/785 (38%), Gaps = 110/785 (14%)
Query: 42 PLQVILGPEQAAVLNCSLGAAAAGPPT-RVTWSKDGDTLLE-----HDHLHLLPNGSLWL 95
P +I+ + A LNC A G PT + W K G+ + H LLP+GSL+
Sbjct: 35 PSDLIVSKGEPATLNCK----AEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF 90
Query: 96 SQPLAPNGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLAD-FSLHPESQTV 154
+ + +S P+ EG Y C+A LG S A +++A L D F +P V
Sbjct: 91 LRIVHGR---KSRPD-----EGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 142
Query: 155 EENGTARFECHI-EGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCV 213
A EC G P P I+W+KD L ++ I + G L I ++SDAG Y CV
Sbjct: 143 AVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCV 202
Query: 214 ATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTP 273
TN + S+ A L+V R S V P N V S +C A DP P
Sbjct: 203 GTNMVGERESEVAELTVLERPS----------FVKRPSNLAVTVDDSAEFKCEARGDPVP 252
Query: 274 FVSWVRQDGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLA 333
V W + DG+ + + L I G Y C A + A A+A L V
Sbjct: 253 TVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGK--AEASATLTVQE 310
Query: 334 APAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGA--------PLRPNGRVKVQG 385
P P T F C A+G P+PA+ W G+ P + + R V
Sbjct: 311 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSV-S 369
Query: 386 GGGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAV----------VVREGLPSAPTRV 435
G L IT + D GYY C N AG A L V V+R+G + V
Sbjct: 370 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 429
Query: 436 TATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDN--VEYQFAVNNDTTELQVRDL 493
T + S + + + + S + + ++N ++ ++A DT
Sbjct: 430 DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAS 489
Query: 494 EPNTDYEFYV-VAYSQLGA----SRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVAWL 548
P+ + + + + G R + P L +PSA + ++ + + + ++W
Sbjct: 490 TPSGEATWSAYIEVQEFGVPVQPPRPTDPNL------IPSAPSKPEVTDVSRNTVTLSW- 542
Query: 549 PLPPSLSNGQV-VKYKIE---YGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAG 604
P+L++G Y IE + G Q + V+ ET + L+PN +Y + A
Sbjct: 543 --QPNLNSGATPTSYIIEAFSHASGSSWQTVAENVK-TETS-AIKGLKPNAIYLFLVRAA 598
Query: 605 TAAGFGAPSQWMHH-RTPSM--------HNQSHVPFAPAELKVQ----AKMESLVVSWQP 651
A G PSQ +T + H Q A L + S+ V W
Sbjct: 599 NAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV 658
Query: 652 PPHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGR 711
I GYK+ +R GA G+ W V VR K + L G
Sbjct: 659 DQQSQYIQGYKILYRPSGA-----------NHGESDWLVFEVRTPAK-NSVVIPDLRKGV 706
Query: 712 LYEVKL-VAFNKHEDGYAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESN--SSTSIWL 768
YE+K FN+ + + + KT ++ P PP V N + T+I +
Sbjct: 707 NYEIKARPFFNEFQGADSEIKFAKT---------LEEAPSAPPQGVTVSKNDGNGTAILV 757
Query: 769 RWKKP 773
W+ P
Sbjct: 758 SWQPP 762
Score = 138 bits (347), Expect = 4e-32
Identities = 224/917 (24%), Positives = 354/917 (38%), Gaps = 129/917 (14%)
Query: 148 HPESQTVEENGTARFECHIEGLPAPIITWEK--DQV-TLPEEPR--LIVLPNGVLQILDV 202
HP V + A C EG P P I W K ++V T ++PR ++LP+G L L +
Sbjct: 34 HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRI 93
Query: 203 -----QESDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVS 257
D G Y CVA N + S A L VA L Q+ P + V
Sbjct: 94 VHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVA---ILRDDFRQN------PSDVMVAV 144
Query: 258 GQSVVMEC-VASADPTPFVSWVRQDGKPI--STDVIVLGRTNLLIANAQPWHSGVYVCRA 314
G+ VMEC P P +SW ++DG P+ + I + L+I + +G YVC
Sbjct: 145 GEPAVMECQPPRGHPEPTISW-KKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC-V 202
Query: 315 NKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAP 374
+ + AEL VL P+ + P L+ T +A F C A G+P P +RW +
Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 262
Query: 375 LRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAV------VV--RE 426
L P R +++ +L I ++ D G Y CVAEN G A A+A+L V VV R+
Sbjct: 263 L-PKSRYEIR-DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRD 320
Query: 427 GLPSAPTRVT--ATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNND 484
+ + VT + + W R Q + FS YQ + +F+V +
Sbjct: 321 QVVALGRTVTFQCEATGNPQPAIFWRR---EGSQNLLFS--YQPPQSSS----RFSV-SQ 370
Query: 485 TTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIR 544
T +L + +++ +D +Y+ + S T A + D + P + P +
Sbjct: 371 TGDLTITNVQ-RSDVGYYICQTLNVAGS-IITKAYLEVTDVIADRPPPVIRQGPVNQTVA 428
Query: 545 VAWLPLPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQ-----PNKVYRV 599
V + ++ G V L ++D + + QL LQ R
Sbjct: 429 VDGTFVLSCVATGSPVPTI----LWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRY 484
Query: 600 RISAGTAAG------------FGAPSQWMHHRTPSMHNQSHVPFAPAELKV-QAKMESLV 646
A T +G FG P Q P++ +P AP++ +V ++
Sbjct: 485 TCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNL-----IPSAPSKPEVTDVSRNTVT 539
Query: 647 VSWQPPPHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQ 706
+SWQP + SG + A A+G +W V K + +
Sbjct: 540 LSWQPNLN----SGATPTSYIIEAFSHASG---------SSWQT--VAENVKTETSAIKG 584
Query: 707 LVPGRLYEVKLVAFNKH--EDGYAAVWKGKTE-----KAPAPDMPIQRGPPLPPAHVHAE 759
L P +Y + A N + D KT+ +QR H+H
Sbjct: 585 LKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNP 644
Query: 760 S-NSSTSIWLRWKKPDFTTVKIVNYTVRFSPWGLRNAS----LVTYYTSSGEDILIGGLK 814
+ SS+SI + W D + I Y + + P G + + T + ++I L+
Sbjct: 645 TVLSSSSIEVHW-TVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLR 703
Query: 815 PFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRLSPL--TPSTVRLHWCPPT 872
YE + + G + TL + PS PP + +S + + + W PP
Sbjct: 704 KGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPP 763
Query: 873 E--PNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESDTRYFFKMGARTEVG 930
E NG + EY + N T+ T G+ FS + L RY ++ A T G
Sbjct: 764 EDTQNGMVQEYKVWCLGNETRYHIN---KTVDGSTFSVVIPFLVPGIRYSVEVAASTGAG 820
Query: 931 PGPFSRLQ--------------DVITLQEKLSDSLDMHSVTGIIVGVCLGLLCLLACMCA 976
G S Q D ++L +++SD + I G+ G C + M
Sbjct: 821 SGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQ---PAFIAGI--GAACWIILMVF 875
Query: 977 GLRRSPHRESLPGLSST 993
+ HR+ GL+ST
Sbjct: 876 SIWLYRHRKKRNGLTST 892
Score = 137 bits (346), Expect = 5e-32
Identities = 161/679 (23%), Positives = 262/679 (38%), Gaps = 94/679 (13%)
Query: 42 PLQVILGPEQAAVLNCSLGAAAAGPPTRVTWSKDGDTLLEHDHLHLLPNGSLWLSQPLAP 101
P V++ + AV+ C P ++W KDG L + D + G L ++
Sbjct: 137 PSDVMVAVGEPAVMECQ--PPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKS 194
Query: 102 NGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTAR 161
+ G Y C+ +G S+ A + + F P + V + +A
Sbjct: 195 DA-------------GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE 241
Query: 162 FECHIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQH 221
F+C G P P + W KD LP+ R + + L+I V D G Y CVA N +
Sbjct: 242 FKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300
Query: 222 FSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQD 281
+ L T + V P + V G++V +C A+ +P P + W R+
Sbjct: 301 EASATL-----------TVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREG 349
Query: 282 GK--------PISTDVIVLGRT-NLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVL 332
+ P S+ + +T +L I N Q G Y+C+ A E+ +
Sbjct: 350 SQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV 409
Query: 333 AA----PAITQAPEALSRTRASTARFV--CRASGEPRPALRWLHNGAPLRPNGRVKVQGG 386
A P I Q P +++T A FV C A+G P P + W +G + Q
Sbjct: 410 IADRPPPVIRQGP--VNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLE 467
Query: 387 GGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAV------------VVREGLPSAPTR 434
G L I L D G Y C+A +G A +A + V +PSAP++
Sbjct: 468 NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSK 527
Query: 435 VTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLE 494
T +S + V ++W+ P ++S + + + A N T ++ L+
Sbjct: 528 PEVTDVSRNTVTLSWQ-PNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLK 586
Query: 495 PNTDYEFYVVAYSQLGASRTSTPA-LVHTLDDVPSAA-------------PQLSLSSP-- 538
PN Y F V A + G S S + V T D +P++ L L +P
Sbjct: 587 PNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTV 646
Query: 539 -NPSDIRVAWLPLPPSLSNGQVVKYKIEY-----GLGKEDQIFSTEVRGNETQLMLNSLQ 592
+ S I V W + + YKI Y G+ D + + +++ L+
Sbjct: 647 LSSSSIEVHWTV---DQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLR 703
Query: 593 PNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQAKME----SLVVS 648
Y ++ GA S+ +T P AP + +K + +++VS
Sbjct: 704 KGVNYEIKARPFFNEFQGADSEIKFAKT-----LEEAPSAPPQGVTVSKNDGNGTAILVS 758
Query: 649 WQPPPHPTQ---ISGYKLY 664
WQPPP TQ + YK++
Sbjct: 759 WQPPPEDTQNGMVQEYKVW 777
Score = 59.7 bits (143), Expect = 2e-08
Identities = 52/207 (25%), Positives = 77/207 (37%), Gaps = 16/207 (7%)
Query: 246 IVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTDVIVLGRTNLLIANAQPW 305
IV P + V G+ + C A PTP + W + G+ + TD +L+ + +
Sbjct: 31 IVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLF 89
Query: 306 ------------HSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTAR 353
GVYVC A + A+ + Q P + A
Sbjct: 90 FLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAV 149
Query: 354 FVCR-ASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAG 412
C+ G P P + W +G+PL ++ GG L+IT DAG Y CV N G
Sbjct: 150 MECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKSDAGKYVCVGTNMVG 208
Query: 413 -MACAAASLAVVVREGLPSAPTRVTAT 438
A L V+ R P+ + T
Sbjct: 209 ERESEVAELTVLERPSFVKRPSNLAVT 235
Score = 39.7 bits (91), Expect = 0.018
Identities = 45/176 (25%), Positives = 70/176 (39%), Gaps = 28/176 (15%)
Query: 302 AQPWHSGVY----VCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTARFVCR 357
A+P H ++ +C ++ R DF P I + P L ++ A C+
Sbjct: 3 AEPAHFYLFGLICLCSGSRLRQEDFP-----------PRIVEHPSDLIVSKGEPATLNCK 51
Query: 358 ASGEPRPALRWLHNGAPLRPN----GRVKVQGGGGSLVITQI-----GLQDAGYYQCVAE 408
A G P P + W G + + ++ GSL +I D G Y CVA
Sbjct: 52 AEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVAR 111
Query: 409 NSAGMACA-AASLAV-VVREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGF 462
N G A + ASL V ++R+ P+ V + AV+ + P H E I +
Sbjct: 112 NYLGEAVSHNASLEVAILRDDFRQNPSDVMVA-VGEPAVMEC-QPPRGHPEPTISW 165
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 165 bits (418), Expect = 2e-40
Identities = 202/785 (25%), Positives = 303/785 (38%), Gaps = 110/785 (14%)
Query: 42 PLQVILGPEQAAVLNCSLGAAAAGPPT-RVTWSKDGDTLLE-----HDHLHLLPNGSLWL 95
P +I+ + A LNC A G PT + W K G+ + H LLP+GSL+
Sbjct: 74 PSDLIVSKGEPATLNCK----AEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF 129
Query: 96 SQPLAPNGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLAD-FSLHPESQTV 154
+ + +S P+ EG Y C+A LG S A +++A L D F +P V
Sbjct: 130 LRIVHGR---KSRPD-----EGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 181
Query: 155 EENGTARFECHI-EGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCV 213
A EC G P P I+W+KD L ++ I + G L I ++SDAG Y CV
Sbjct: 182 AVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCV 241
Query: 214 ATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTP 273
TN + S+ A L+V R S V P N V S +C A DP P
Sbjct: 242 GTNMVGERESEVAELTVLERPS----------FVKRPSNLAVTVDDSAEFKCEARGDPVP 291
Query: 274 FVSWVRQDGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLA 333
V W + DG+ + + L I G Y C A + A A+A L V
Sbjct: 292 TVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGK--AEASATLTVQE 349
Query: 334 APAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGA--------PLRPNGRVKVQG 385
P P T F C A+G P+PA+ W G+ P + + R V
Sbjct: 350 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSV-S 408
Query: 386 GGGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAV----------VVREGLPSAPTRV 435
G L IT + D GYY C N AG A L V V+R+G + V
Sbjct: 409 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 468
Query: 436 TATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDN--VEYQFAVNNDTTELQVRDL 493
T + S + + + + S + + ++N ++ ++A DT
Sbjct: 469 DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAS 528
Query: 494 EPNTDYEFYV-VAYSQLGA----SRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVAWL 548
P+ + + + + G R + P L +PSA + ++ + + + ++W
Sbjct: 529 TPSGEATWSAYIEVQEFGVPVQPPRPTDPNL------IPSAPSKPEVTDVSRNTVTLSW- 581
Query: 549 PLPPSLSNGQV-VKYKIE---YGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAG 604
P+L++G Y IE + G Q + V+ ET + L+PN +Y + A
Sbjct: 582 --QPNLNSGATPTSYIIEAFSHASGSSWQTVAENVK-TETS-AIKGLKPNAIYLFLVRAA 637
Query: 605 TAAGFGAPSQWMHH-RTPSM--------HNQSHVPFAPAELKVQ----AKMESLVVSWQP 651
A G PSQ +T + H Q A L + S+ V W
Sbjct: 638 NAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV 697
Query: 652 PPHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGR 711
I GYK+ +R GA G+ W V VR K + L G
Sbjct: 698 DQQSQYIQGYKILYRPSGA-----------NHGESDWLVFEVRTPAK-NSVVIPDLRKGV 745
Query: 712 LYEVKL-VAFNKHEDGYAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESN--SSTSIWL 768
YE+K FN+ + + + KT ++ P PP V N + T+I +
Sbjct: 746 NYEIKARPFFNEFQGADSEIKFAKT---------LEEAPSAPPQGVTVSKNDGNGTAILV 796
Query: 769 RWKKP 773
W+ P
Sbjct: 797 SWQPP 801
Score = 138 bits (347), Expect = 4e-32
Identities = 224/917 (24%), Positives = 354/917 (38%), Gaps = 129/917 (14%)
Query: 148 HPESQTVEENGTARFECHIEGLPAPIITWEK--DQV-TLPEEPR--LIVLPNGVLQILDV 202
HP V + A C EG P P I W K ++V T ++PR ++LP+G L L +
Sbjct: 73 HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRI 132
Query: 203 -----QESDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVS 257
D G Y CVA N + S A L VA L Q+ P + V
Sbjct: 133 VHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVA---ILRDDFRQN------PSDVMVAV 183
Query: 258 GQSVVMEC-VASADPTPFVSWVRQDGKPI--STDVIVLGRTNLLIANAQPWHSGVYVCRA 314
G+ VMEC P P +SW ++DG P+ + I + L+I + +G YVC
Sbjct: 184 GEPAVMECQPPRGHPEPTISW-KKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC-V 241
Query: 315 NKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAP 374
+ + AEL VL P+ + P L+ T +A F C A G+P P +RW +
Sbjct: 242 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 301
Query: 375 LRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAV------VV--RE 426
L P R +++ +L I ++ D G Y CVAEN G A A+A+L V VV R+
Sbjct: 302 L-PKSRYEIR-DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRD 359
Query: 427 GLPSAPTRVT--ATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNND 484
+ + VT + + W R Q + FS YQ + +F+V +
Sbjct: 360 QVVALGRTVTFQCEATGNPQPAIFWRR---EGSQNLLFS--YQPPQSSS----RFSV-SQ 409
Query: 485 TTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIR 544
T +L + +++ +D +Y+ + S T A + D + P + P +
Sbjct: 410 TGDLTITNVQ-RSDVGYYICQTLNVAGS-IITKAYLEVTDVIADRPPPVIRQGPVNQTVA 467
Query: 545 VAWLPLPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQ-----PNKVYRV 599
V + ++ G V L ++D + + QL LQ R
Sbjct: 468 VDGTFVLSCVATGSPVPTI----LWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRY 523
Query: 600 RISAGTAAG------------FGAPSQWMHHRTPSMHNQSHVPFAPAELKV-QAKMESLV 646
A T +G FG P Q P++ +P AP++ +V ++
Sbjct: 524 TCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNL-----IPSAPSKPEVTDVSRNTVT 578
Query: 647 VSWQPPPHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQ 706
+SWQP + SG + A A+G +W V K + +
Sbjct: 579 LSWQPNLN----SGATPTSYIIEAFSHASG---------SSWQT--VAENVKTETSAIKG 623
Query: 707 LVPGRLYEVKLVAFNKH--EDGYAAVWKGKTE-----KAPAPDMPIQRGPPLPPAHVHAE 759
L P +Y + A N + D KT+ +QR H+H
Sbjct: 624 LKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNP 683
Query: 760 S-NSSTSIWLRWKKPDFTTVKIVNYTVRFSPWGLRNAS----LVTYYTSSGEDILIGGLK 814
+ SS+SI + W D + I Y + + P G + + T + ++I L+
Sbjct: 684 TVLSSSSIEVHW-TVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLR 742
Query: 815 PFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRLSPL--TPSTVRLHWCPPT 872
YE + + G + TL + PS PP + +S + + + W PP
Sbjct: 743 KGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPP 802
Query: 873 E--PNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESDTRYFFKMGARTEVG 930
E NG + EY + N T+ T G+ FS + L RY ++ A T G
Sbjct: 803 EDTQNGMVQEYKVWCLGNETRYHIN---KTVDGSTFSVVIPFLVPGIRYSVEVAASTGAG 859
Query: 931 PGPFSRLQ--------------DVITLQEKLSDSLDMHSVTGIIVGVCLGLLCLLACMCA 976
G S Q D ++L +++SD + I G+ G C + M
Sbjct: 860 SGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQ---PAFIAGI--GAACWIILMVF 914
Query: 977 GLRRSPHRESLPGLSST 993
+ HR+ GL+ST
Sbjct: 915 SIWLYRHRKKRNGLTST 931
Score = 137 bits (346), Expect = 5e-32
Identities = 161/679 (23%), Positives = 262/679 (38%), Gaps = 94/679 (13%)
Query: 42 PLQVILGPEQAAVLNCSLGAAAAGPPTRVTWSKDGDTLLEHDHLHLLPNGSLWLSQPLAP 101
P V++ + AV+ C P ++W KDG L + D + G L ++
Sbjct: 176 PSDVMVAVGEPAVMECQ--PPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKS 233
Query: 102 NGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTAR 161
+ G Y C+ +G S+ A + + F P + V + +A
Sbjct: 234 DA-------------GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE 280
Query: 162 FECHIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQH 221
F+C G P P + W KD LP+ R + + L+I V D G Y CVA N +
Sbjct: 281 FKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 339
Query: 222 FSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQD 281
+ L T + V P + V G++V +C A+ +P P + W R+
Sbjct: 340 EASATL-----------TVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREG 388
Query: 282 GK--------PISTDVIVLGRT-NLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVL 332
+ P S+ + +T +L I N Q G Y+C+ A E+ +
Sbjct: 389 SQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV 448
Query: 333 AA----PAITQAPEALSRTRASTARFV--CRASGEPRPALRWLHNGAPLRPNGRVKVQGG 386
A P I Q P +++T A FV C A+G P P + W +G + Q
Sbjct: 449 IADRPPPVIRQGP--VNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLE 506
Query: 387 GGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAV------------VVREGLPSAPTR 434
G L I L D G Y C+A +G A +A + V +PSAP++
Sbjct: 507 NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSK 566
Query: 435 VTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLE 494
T +S + V ++W+ P ++S + + + A N T ++ L+
Sbjct: 567 PEVTDVSRNTVTLSWQ-PNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLK 625
Query: 495 PNTDYEFYVVAYSQLGASRTSTPA-LVHTLDDVPSAA-------------PQLSLSSP-- 538
PN Y F V A + G S S + V T D +P++ L L +P
Sbjct: 626 PNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTV 685
Query: 539 -NPSDIRVAWLPLPPSLSNGQVVKYKIEY-----GLGKEDQIFSTEVRGNETQLMLNSLQ 592
+ S I V W + + YKI Y G+ D + + +++ L+
Sbjct: 686 LSSSSIEVHWTV---DQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLR 742
Query: 593 PNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQAKME----SLVVS 648
Y ++ GA S+ +T P AP + +K + +++VS
Sbjct: 743 KGVNYEIKARPFFNEFQGADSEIKFAKT-----LEEAPSAPPQGVTVSKNDGNGTAILVS 797
Query: 649 WQPPPHPTQ---ISGYKLY 664
WQPPP TQ + YK++
Sbjct: 798 WQPPPEDTQNGMVQEYKVW 816
Score = 60.1 bits (144), Expect = 1e-08
Identities = 55/224 (24%), Positives = 82/224 (36%), Gaps = 16/224 (7%)
Query: 229 SVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTD 288
S+ + GS IV P + V G+ + C A PTP + W + G+ + TD
Sbjct: 53 SLGYTGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK-GGERVETD 111
Query: 289 VIVLGRTNLLIANAQPW------------HSGVYVCRANKPRTRDFATAAAELRVLAAPA 336
+L+ + + GVYVC A + A+ +
Sbjct: 112 KDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD 171
Query: 337 ITQAPEALSRTRASTARFVCR-ASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQI 395
Q P + A C+ G P P + W +G+PL ++ GG L+IT
Sbjct: 172 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYT 230
Query: 396 GLQDAGYYQCVAENSAG-MACAAASLAVVVREGLPSAPTRVTAT 438
DAG Y CV N G A L V+ R P+ + T
Sbjct: 231 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVT 274
Score = 38.1 bits (87), Expect = 0.053
Identities = 38/139 (27%), Positives = 57/139 (41%), Gaps = 13/139 (9%)
Query: 335 PAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPN----GRVKVQGGGGSL 390
P I + P L ++ A C+A G P P + W G + + ++ GSL
Sbjct: 68 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 127
Query: 391 VITQI-----GLQDAGYYQCVAENSAGMACA-AASLAV-VVREGLPSAPTRVTATPLSSS 443
+I D G Y CVA N G A + ASL V ++R+ P+ V +
Sbjct: 128 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA-VGEP 186
Query: 444 AVLVAWERPEMHSEQIIGF 462
AV+ + P H E I +
Sbjct: 187 AVMEC-QPPRGHPEPTISW 204
>gi|81158224 neuronal cell adhesion molecule isoform B precursor [Homo
sapiens]
Length = 1183
Score = 165 bits (417), Expect = 3e-40
Identities = 213/855 (24%), Positives = 338/855 (39%), Gaps = 103/855 (12%)
Query: 163 ECHIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHF 222
EC EGLP PII W K+ LP+ + LQI+ V E+D+G Y+C+A N
Sbjct: 285 ECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKN------ 338
Query: 223 SQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDG 282
AL ++ H S+ + AP+N + G+ + C A+ +P P +SW+ +G
Sbjct: 339 ---ALGAIHHTISVRVKAAP--YWITAPQNLVLSPGEDGTLICRANGNPKPRISWL-TNG 392
Query: 283 KPISTDVIVLGR----TNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAP--A 336
PI R ++ +N Q S VY C A+ + A A + VLA P
Sbjct: 393 VPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNAS--NEYGYLLANAFVNVLAEPPRI 450
Query: 337 ITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIG 396
+T A A C G P P + W + + V G+L I
Sbjct: 451 LTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQ 510
Query: 397 LQDAGYYQCVAENSAGMACAAASLAVVVREGLPSAPTRVTATP---LSSSAVLVAWERPE 453
G Y CVA N GMA L + PT + P + +V++E
Sbjct: 511 KDSTGTYTCVARNKLGMAKNEVHLEI-------KDPTWIVKQPEYAVVQRGSMVSFECKV 563
Query: 454 MHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASR 513
H + L + R + + E +F V+ D L V D+ + + VA + L +
Sbjct: 564 KHDHTLSLTVLWLKDNRELPSDE-RFTVDKD--HLVVADVSDDDSGTYTCVANTTLDSVS 620
Query: 514 TSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKEDQ 573
S V ++ DVP+ L L+ ++++W P +N + K+ IEY ED
Sbjct: 621 ASA---VLSVVDVPNPPFDLELTDQLDKSVQLSW--TPGDDNNSPITKFIIEY----EDA 671
Query: 574 I-------FSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQ 626
+ TEV G +T L L P Y R+ A + G PS+
Sbjct: 672 MHKPGLWHHQTEVSGTQTTAQL-KLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEP 730
Query: 627 SHVPFAPAELKVQAKMESLVVSWQPPPHPTQISG----YKLYWREVGAEEEANGDRLPGG 682
P A L ++ ++LV++W+ P + + +G YK+ WR+
Sbjct: 731 DKNPTAVEGL--GSEPDNLVITWK-PLNGFESNGPGLQYKVSWRQKD------------- 774
Query: 683 RGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYA---AVWKGKTEKAP 739
GD W V K VP Y +K+ A N + G+A AV G +
Sbjct: 775 -GDDEWTSVVVANVSKYIVSGTPTFVP---YLIKVQALN--DMGFAPEPAVVMGHS---- 824
Query: 740 APDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRFSPWGLRNAS--- 796
D+P+ + P +V +ST + W +++ R W +++S
Sbjct: 825 GEDLPM-----VAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRN 879
Query: 797 -------LVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPST 849
++T+ S +L GL+PF+ Y V+ +GP S P+ +
Sbjct: 880 RRHIEKKILTFQGSKTHGML-PGLEPFSHYTLNVRVVNGKGEGP-ASPDRVFNTPEGVPS 937
Query: 850 PPSDLRLSPLTPSTVRLHWCPPTEPNGEIVEYLILYSS-NHTQPEHQWTLLTTQGNIFSA 908
PS L++ T ++ L W PP+ PNG + EY + Y N T L N
Sbjct: 938 APSSLKIVNPTLDSLTLEWDPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRW 997
Query: 909 EVHGLESDTRYFFKMGARTEVGPGPFSRLQDVITLQEKLSDSLDMHSVTGIIVGV--CLG 966
+ L TRY F A+T G G + V T+ E ++ + G +G+ +
Sbjct: 998 TLKNLNFSTRYKFYFYAQTSAGSGSQITEEAVTTVDEAMASRQVDIATQGWFIGLMCAVA 1057
Query: 967 LLCLLACMCAGLRRS 981
LL L+ + +RR+
Sbjct: 1058 LLILILLIVCFIRRN 1072
Score = 105 bits (261), Expect = 4e-22
Identities = 137/548 (25%), Positives = 218/548 (39%), Gaps = 66/548 (12%)
Query: 3 RGDAGRGRGLLALTFCLLAARGELLLPQETTVELSCGVGPLQVILGPEQAAVLNCSLGAA 62
R AGR +L L + A L L Q T+ P I+ P + V+ C A
Sbjct: 11 RLSAGRVPLILFLCQMISALEVPLDLVQPPTITQQ---SPKDYIIDPRENIVIQCE---A 64
Query: 63 AAGPPTRVTWSKDGDTL-LEHDHLHLLPNGSLWLSQPLAPNGSDESVPEAVGVIEGNYSC 121
PP +W+++G ++ D L + G+ L + G E+ EG Y C
Sbjct: 65 KGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETY-------EGVYQC 117
Query: 122 LAHGPLGVLASQTAVVKLATLADFSLHP-ESQTVEENGTARFECHIE-GLPAPIITWEKD 179
A G S VV+ + ++ E T++ + C GLP PII W +
Sbjct: 118 TARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDN 177
Query: 180 QVT-LPEEPRLIVLPNGVLQILDVQESDAGP-YRCVATNSARQHFSQEA-----LLSVAH 232
LP+ R+ NG L +V D Y C A + Q Q+ ++SV
Sbjct: 178 SFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDE 237
Query: 233 RGSLASTRGQDVVIVAA------------PE----NTTVVSGQSVVMECVASADPTPFVS 276
+ D A PE N + G + +EC+A PTP +
Sbjct: 238 LNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIY 297
Query: 277 WVRQDGK-PISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAP 335
W ++DG P + V L I + SG Y C A T + +RV AAP
Sbjct: 298 WAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTIS--VRVKAAP 355
Query: 336 AITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLR-----PNGRVKVQGGGGSL 390
AP+ L + +CRA+G P+P + WL NG P+ P+ ++ G ++
Sbjct: 356 YWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKI----DGDTI 411
Query: 391 VITQIGLQDAGYYQCVAENSAGMACAAASLAVVVREGLPSAPTRVTATPLSSSAVLVAWE 450
+ + + + + YQC A N G A A + V+ + P R+ TP ++ ++A
Sbjct: 412 IFSNVQERSSAVYQCNASNEYGYLLANAFVNVL------AEPPRI-LTPANTLYQVIA-N 463
Query: 451 RPEMHSEQIIGFSL----HYQKARGMDNVEYQFAVN-NDTTELQVRDLEPNTDYEFYVVA 505
RP + G L ++ A+G E + ++ N T E+ V + Y VA
Sbjct: 464 RPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYT--CVA 521
Query: 506 YSQLGASR 513
++LG ++
Sbjct: 522 RNKLGMAK 529
Score = 53.9 bits (128), Expect = 9e-07
Identities = 49/181 (27%), Positives = 75/181 (41%), Gaps = 22/181 (12%)
Query: 53 AVLNCSLGAAAAGPPTRVTWSKDGDTLLEHDHLHLL-PNGSLWLSQPLAPNGSDESVPEA 111
A+L+C A P + W K H+ +++L NG+L +P A
Sbjct: 466 ALLDC---AFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTL-------------EIPVA 509
Query: 112 VGVIEGNYSCLAHGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTARFECHI--EGL 169
G Y+C+A LG +A +++ PE V+ FEC + +
Sbjct: 510 QKDSTGTYTCVARNKLG-MAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHT 568
Query: 170 PAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEALLS 229
+ + W KD LP + R V L + DV + D+G Y CVA N+ S A+LS
Sbjct: 569 LSLTVLWLKDNRELPSDERFTV-DKDHLVVADVSDDDSGTYTCVA-NTTLDSVSASAVLS 626
Query: 230 V 230
V
Sbjct: 627 V 627
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 162 bits (410), Expect = 2e-39
Identities = 200/786 (25%), Positives = 304/786 (38%), Gaps = 109/786 (13%)
Query: 42 PLQVILGPEQAAVLNCSLGAAAAGPPT-RVTWSKDGDTLLE-----HDHLHLLPNGSLWL 95
P +I+ + A LNC A G PT + W K G+ + H LLP+GSL+
Sbjct: 35 PSDLIVSKGEPATLNCK----AEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF 90
Query: 96 SQPLAPNGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLAD-FSLHPESQTV 154
+ + +S P+ EG Y C+A LG S A +++A L D F +P V
Sbjct: 91 LRIVHGR---KSRPD-----EGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 142
Query: 155 EENGTARFECHI-EGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCV 213
A EC G P P I+W+KD L ++ I + G L I ++SDAG Y CV
Sbjct: 143 AVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCV 202
Query: 214 ATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTP 273
TN + S+ A L+V R S V P N V S +C A DP P
Sbjct: 203 GTNMVGERESEVAELTVLERPS----------FVKRPSNLAVTVDDSAEFKCEARGDPVP 252
Query: 274 FVSWVRQDGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLA 333
V W + DG+ + + L I G Y C A + A+A ++V +
Sbjct: 253 TVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGS 312
Query: 334 APA-ITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGA--------PLRPNGRVKVQ 384
P P T F C A+G P+PA+ W G+ P + + R V
Sbjct: 313 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSV- 371
Query: 385 GGGGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAV----------VVREGLPSAPTR 434
G L IT + D GYY C N AG A L V V+R+G +
Sbjct: 372 SQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVA 431
Query: 435 VTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDN--VEYQFAVNNDTTELQVRD 492
V T + S + + + + S + + ++N ++ ++A DT
Sbjct: 432 VDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIA 491
Query: 493 LEPNTDYEFYV-VAYSQLGA----SRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVAW 547
P+ + + + + G R + P L +PSA + ++ + + + ++W
Sbjct: 492 STPSGEATWSAYIEVQEFGVPVQPPRPTDPNL------IPSAPSKPEVTDVSRNTVTLSW 545
Query: 548 LPLPPSLSNGQV-VKYKIE---YGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISA 603
P+L++G Y IE + G Q + V+ ET + L+PN +Y + A
Sbjct: 546 ---QPNLNSGATPTSYIIEAFSHASGSSWQTVAENVK-TETS-AIKGLKPNAIYLFLVRA 600
Query: 604 GTAAGFGAPSQWMHH-RTPSM--------HNQSHVPFAPAELKVQ----AKMESLVVSWQ 650
A G PSQ +T + H Q A L + S+ V W
Sbjct: 601 ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 660
Query: 651 PPPHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPG 710
I GYK+ +R GA G+ W V VR K + L G
Sbjct: 661 VDQQSQYIQGYKILYRPSGA-----------NHGESDWLVFEVRTPAK-NSVVIPDLRKG 708
Query: 711 RLYEVKL-VAFNKHEDGYAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESN--SSTSIW 767
YE+K FN+ + + + KT ++ P PP V N + T+I
Sbjct: 709 VNYEIKARPFFNEFQGADSEIKFAKT---------LEEAPSAPPQGVTVSKNDGNGTAIL 759
Query: 768 LRWKKP 773
+ W+ P
Sbjct: 760 VSWQPP 765
Score = 140 bits (353), Expect = 8e-33
Identities = 226/935 (24%), Positives = 352/935 (37%), Gaps = 140/935 (14%)
Query: 148 HPESQTVEENGTARFECHIEGLPAPIITWEK--DQV-TLPEEPR--LIVLPNGVLQILDV 202
HP V + A C EG P P I W K ++V T ++PR ++LP+G L L +
Sbjct: 34 HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRI 93
Query: 203 -----QESDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVS 257
D G Y CVA N + S A L VA L Q+ P + V
Sbjct: 94 VHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVA---ILRDDFRQN------PSDVMVAV 144
Query: 258 GQSVVMEC-VASADPTPFVSWVRQDGKPI--STDVIVLGRTNLLIANAQPWHSGVYVCRA 314
G+ VMEC P P +SW ++DG P+ + I + L+I + +G YVC
Sbjct: 145 GEPAVMECQPPRGHPEPTISW-KKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC-V 202
Query: 315 NKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAP 374
+ + AEL VL P+ + P L+ T +A F C A G+P P +RW +
Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 262
Query: 375 LRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAVVVREGLPSAPTR 434
L P R +++ +L I ++ D G Y CVAEN G A A+A+L V V S P
Sbjct: 263 L-PKSRYEIR-DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV----GSEPPH 316
Query: 435 VTATPLSSSAVL-----------------VAWERPEMHSEQIIGFSLHYQKARGMDNVEY 477
P L + W R Q + FS YQ +
Sbjct: 317 FVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRR---EGSQNLLFS--YQPPQSSS---- 367
Query: 478 QFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSS 537
+F+V + T +L + +++ +D +Y+ + S T A + D + P +
Sbjct: 368 RFSV-SQTGDLTITNVQ-RSDVGYYICQTLNVAGS-IITKAYLEVTDVIADRPPPVIRQG 424
Query: 538 PNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQ----- 592
P + V + ++ G V L ++D + + QL LQ
Sbjct: 425 PVNQTVAVDGTFVLSCVATGSPVPTI----LWRKDGVLVSTQDSRIKQLENGVLQIRYAK 480
Query: 593 PNKVYRVRISAGTAAG------------FGAPSQWMHHRTPSMHNQSHVPFAPAELKV-Q 639
R A T +G FG P Q P++ +P AP++ +V
Sbjct: 481 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNL-----IPSAPSKPEVTD 535
Query: 640 AKMESLVVSWQPPPHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKV 699
++ +SWQP + SG + A A+G +W V K
Sbjct: 536 VSRNTVTLSWQPNLN----SGATPTSYIIEAFSHASG---------SSWQT--VAENVKT 580
Query: 700 KQYELTQLVPGRLYEVKLVAFNKH--EDGYAAVWKGKTE-----KAPAPDMPIQRGPPLP 752
+ + L P +Y + A N + D KT+ +QR
Sbjct: 581 ETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNA 640
Query: 753 PAHVHAES-NSSTSIWLRWKKPDFTTVKIVNYTVRFSPWGLRNAS----LVTYYTSSGED 807
H+H + SS+SI + W D + I Y + + P G + + T +
Sbjct: 641 VLHLHNPTVLSSSSIEVHW-TVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNS 699
Query: 808 ILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRLSPL--TPSTVR 865
++I L+ YE + + G + TL + PS PP + +S + +
Sbjct: 700 VVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAIL 759
Query: 866 LHWCPPTE--PNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESDTRYFFKM 923
+ W PP E NG + EY + N T+ T G+ FS + L RY ++
Sbjct: 760 VSWQPPPEDTQNGMVQEYKVWCLGNETRYHIN---KTVDGSTFSVVIPFLVPGIRYSVEV 816
Query: 924 GARTEVGPGPFSRLQ--------------DVITLQEKLSDSLDMHSVTGIIVGVCLGLLC 969
A T G G S Q D ++L +++SD + I G+ G C
Sbjct: 817 AASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQ---PAFIAGI--GAAC 871
Query: 970 LLACMCAGLRRSPHRESLPGLSSTATPGNPALYSR 1004
+ M + HR+ GL+ST Y R
Sbjct: 872 WIILMVFSIWLYRHRKKRNGLTSTYAGIRKVTYQR 906
Score = 137 bits (346), Expect = 5e-32
Identities = 160/679 (23%), Positives = 261/679 (38%), Gaps = 91/679 (13%)
Query: 42 PLQVILGPEQAAVLNCSLGAAAAGPPTRVTWSKDGDTLLEHDHLHLLPNGSLWLSQPLAP 101
P V++ + AV+ C P ++W KDG L + D + G L ++
Sbjct: 137 PSDVMVAVGEPAVMECQ--PPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKS 194
Query: 102 NGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTAR 161
+ G Y C+ +G S+ A + + F P + V + +A
Sbjct: 195 DA-------------GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE 241
Query: 162 FECHIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQH 221
F+C G P P + W KD LP+ R + + L+I V D G Y CVA N +
Sbjct: 242 FKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300
Query: 222 FSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQD 281
+ L + V P + V G++V +C A+ +P P + W R+
Sbjct: 301 EASATLT--------VQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREG 352
Query: 282 GK--------PISTDVIVLGRT-NLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVL 332
+ P S+ + +T +L I N Q G Y+C+ A E+ +
Sbjct: 353 SQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV 412
Query: 333 AA----PAITQAPEALSRTRASTARFV--CRASGEPRPALRWLHNGAPLRPNGRVKVQGG 386
A P I Q P +++T A FV C A+G P P + W +G + Q
Sbjct: 413 IADRPPPVIRQGP--VNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLE 470
Query: 387 GGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAV------------VVREGLPSAPTR 434
G L I L D G Y C+A +G A +A + V +PSAP++
Sbjct: 471 NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSK 530
Query: 435 VTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLE 494
T +S + V ++W+ P ++S + + + A N T ++ L+
Sbjct: 531 PEVTDVSRNTVTLSWQ-PNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLK 589
Query: 495 PNTDYEFYVVAYSQLGASRTSTPA-LVHTLDDVPSAA-------------PQLSLSSP-- 538
PN Y F V A + G S S + V T D +P++ L L +P
Sbjct: 590 PNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTV 649
Query: 539 -NPSDIRVAWLPLPPSLSNGQVVKYKIEY-----GLGKEDQIFSTEVRGNETQLMLNSLQ 592
+ S I V W + + YKI Y G+ D + + +++ L+
Sbjct: 650 LSSSSIEVHWTV---DQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLR 706
Query: 593 PNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQAKME----SLVVS 648
Y ++ GA S+ +T P AP + +K + +++VS
Sbjct: 707 KGVNYEIKARPFFNEFQGADSEIKFAKT-----LEEAPSAPPQGVTVSKNDGNGTAILVS 761
Query: 649 WQPPPHPTQ---ISGYKLY 664
WQPPP TQ + YK++
Sbjct: 762 WQPPPEDTQNGMVQEYKVW 780
Score = 59.7 bits (143), Expect = 2e-08
Identities = 52/207 (25%), Positives = 77/207 (37%), Gaps = 16/207 (7%)
Query: 246 IVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTDVIVLGRTNLLIANAQPW 305
IV P + V G+ + C A PTP + W + G+ + TD +L+ + +
Sbjct: 31 IVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLF 89
Query: 306 ------------HSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTAR 353
GVYVC A + A+ + Q P + A
Sbjct: 90 FLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAV 149
Query: 354 FVCR-ASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAG 412
C+ G P P + W +G+PL ++ GG L+IT DAG Y CV N G
Sbjct: 150 MECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKSDAGKYVCVGTNMVG 208
Query: 413 -MACAAASLAVVVREGLPSAPTRVTAT 438
A L V+ R P+ + T
Sbjct: 209 ERESEVAELTVLERPSFVKRPSNLAVT 235
Score = 39.7 bits (91), Expect = 0.018
Identities = 45/176 (25%), Positives = 70/176 (39%), Gaps = 28/176 (15%)
Query: 302 AQPWHSGVY----VCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTARFVCR 357
A+P H ++ +C ++ R DF P I + P L ++ A C+
Sbjct: 3 AEPAHFYLFGLICLCSGSRLRQEDFP-----------PRIVEHPSDLIVSKGEPATLNCK 51
Query: 358 ASGEPRPALRWLHNGAPLRPN----GRVKVQGGGGSLVITQI-----GLQDAGYYQCVAE 408
A G P P + W G + + ++ GSL +I D G Y CVA
Sbjct: 52 AEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVAR 111
Query: 409 NSAGMACA-AASLAV-VVREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGF 462
N G A + ASL V ++R+ P+ V + AV+ + P H E I +
Sbjct: 112 NYLGEAVSHNASLEVAILRDDFRQNPSDVMVA-VGEPAVMEC-QPPRGHPEPTISW 165
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 162 bits (410), Expect = 2e-39
Identities = 200/786 (25%), Positives = 304/786 (38%), Gaps = 109/786 (13%)
Query: 42 PLQVILGPEQAAVLNCSLGAAAAGPPT-RVTWSKDGDTLLE-----HDHLHLLPNGSLWL 95
P +I+ + A LNC A G PT + W K G+ + H LLP+GSL+
Sbjct: 35 PSDLIVSKGEPATLNCK----AEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF 90
Query: 96 SQPLAPNGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLAD-FSLHPESQTV 154
+ + +S P+ EG Y C+A LG S A +++A L D F +P V
Sbjct: 91 LRIVHGR---KSRPD-----EGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 142
Query: 155 EENGTARFECHI-EGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCV 213
A EC G P P I+W+KD L ++ I + G L I ++SDAG Y CV
Sbjct: 143 AVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCV 202
Query: 214 ATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTP 273
TN + S+ A L+V R S V P N V S +C A DP P
Sbjct: 203 GTNMVGERESEVAELTVLERPS----------FVKRPSNLAVTVDDSAEFKCEARGDPVP 252
Query: 274 FVSWVRQDGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLA 333
V W + DG+ + + L I G Y C A + A+A ++V +
Sbjct: 253 TVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGS 312
Query: 334 APA-ITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGA--------PLRPNGRVKVQ 384
P P T F C A+G P+PA+ W G+ P + + R V
Sbjct: 313 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSV- 371
Query: 385 GGGGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAV----------VVREGLPSAPTR 434
G L IT + D GYY C N AG A L V V+R+G +
Sbjct: 372 SQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVA 431
Query: 435 VTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDN--VEYQFAVNNDTTELQVRD 492
V T + S + + + + S + + ++N ++ ++A DT
Sbjct: 432 VDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIA 491
Query: 493 LEPNTDYEFYV-VAYSQLGA----SRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVAW 547
P+ + + + + G R + P L +PSA + ++ + + + ++W
Sbjct: 492 STPSGEATWSAYIEVQEFGVPVQPPRPTDPNL------IPSAPSKPEVTDVSRNTVTLSW 545
Query: 548 LPLPPSLSNGQV-VKYKIE---YGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISA 603
P+L++G Y IE + G Q + V+ ET + L+PN +Y + A
Sbjct: 546 ---QPNLNSGATPTSYIIEAFSHASGSSWQTVAENVK-TETS-AIKGLKPNAIYLFLVRA 600
Query: 604 GTAAGFGAPSQWMHH-RTPSM--------HNQSHVPFAPAELKVQ----AKMESLVVSWQ 650
A G PSQ +T + H Q A L + S+ V W
Sbjct: 601 ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 660
Query: 651 PPPHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPG 710
I GYK+ +R GA G+ W V VR K + L G
Sbjct: 661 VDQQSQYIQGYKILYRPSGA-----------NHGESDWLVFEVRTPAK-NSVVIPDLRKG 708
Query: 711 RLYEVKL-VAFNKHEDGYAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESN--SSTSIW 767
YE+K FN+ + + + KT ++ P PP V N + T+I
Sbjct: 709 VNYEIKARPFFNEFQGADSEIKFAKT---------LEEAPSAPPQGVTVSKNDGNGTAIL 759
Query: 768 LRWKKP 773
+ W+ P
Sbjct: 760 VSWQPP 765
Score = 140 bits (353), Expect = 8e-33
Identities = 226/935 (24%), Positives = 352/935 (37%), Gaps = 140/935 (14%)
Query: 148 HPESQTVEENGTARFECHIEGLPAPIITWEK--DQV-TLPEEPR--LIVLPNGVLQILDV 202
HP V + A C EG P P I W K ++V T ++PR ++LP+G L L +
Sbjct: 34 HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRI 93
Query: 203 -----QESDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVS 257
D G Y CVA N + S A L VA L Q+ P + V
Sbjct: 94 VHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVA---ILRDDFRQN------PSDVMVAV 144
Query: 258 GQSVVMEC-VASADPTPFVSWVRQDGKPI--STDVIVLGRTNLLIANAQPWHSGVYVCRA 314
G+ VMEC P P +SW ++DG P+ + I + L+I + +G YVC
Sbjct: 145 GEPAVMECQPPRGHPEPTISW-KKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC-V 202
Query: 315 NKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAP 374
+ + AEL VL P+ + P L+ T +A F C A G+P P +RW +
Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 262
Query: 375 LRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAVVVREGLPSAPTR 434
L P R +++ +L I ++ D G Y CVAEN G A A+A+L V V S P
Sbjct: 263 L-PKSRYEIR-DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV----GSEPPH 316
Query: 435 VTATPLSSSAVL-----------------VAWERPEMHSEQIIGFSLHYQKARGMDNVEY 477
P L + W R Q + FS YQ +
Sbjct: 317 FVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRR---EGSQNLLFS--YQPPQSSS---- 367
Query: 478 QFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSS 537
+F+V + T +L + +++ +D +Y+ + S T A + D + P +
Sbjct: 368 RFSV-SQTGDLTITNVQ-RSDVGYYICQTLNVAGS-IITKAYLEVTDVIADRPPPVIRQG 424
Query: 538 PNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQ----- 592
P + V + ++ G V L ++D + + QL LQ
Sbjct: 425 PVNQTVAVDGTFVLSCVATGSPVPTI----LWRKDGVLVSTQDSRIKQLENGVLQIRYAK 480
Query: 593 PNKVYRVRISAGTAAG------------FGAPSQWMHHRTPSMHNQSHVPFAPAELKV-Q 639
R A T +G FG P Q P++ +P AP++ +V
Sbjct: 481 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNL-----IPSAPSKPEVTD 535
Query: 640 AKMESLVVSWQPPPHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKV 699
++ +SWQP + SG + A A+G +W V K
Sbjct: 536 VSRNTVTLSWQPNLN----SGATPTSYIIEAFSHASG---------SSWQT--VAENVKT 580
Query: 700 KQYELTQLVPGRLYEVKLVAFNKH--EDGYAAVWKGKTE-----KAPAPDMPIQRGPPLP 752
+ + L P +Y + A N + D KT+ +QR
Sbjct: 581 ETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNA 640
Query: 753 PAHVHAES-NSSTSIWLRWKKPDFTTVKIVNYTVRFSPWGLRNAS----LVTYYTSSGED 807
H+H + SS+SI + W D + I Y + + P G + + T +
Sbjct: 641 VLHLHNPTVLSSSSIEVHW-TVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNS 699
Query: 808 ILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRLSPL--TPSTVR 865
++I L+ YE + + G + TL + PS PP + +S + +
Sbjct: 700 VVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAIL 759
Query: 866 LHWCPPTE--PNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESDTRYFFKM 923
+ W PP E NG + EY + N T+ T G+ FS + L RY ++
Sbjct: 760 VSWQPPPEDTQNGMVQEYKVWCLGNETRYHIN---KTVDGSTFSVVIPFLVPGIRYSVEV 816
Query: 924 GARTEVGPGPFSRLQ--------------DVITLQEKLSDSLDMHSVTGIIVGVCLGLLC 969
A T G G S Q D ++L +++SD + I G+ G C
Sbjct: 817 AASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQ---PAFIAGI--GAAC 871
Query: 970 LLACMCAGLRRSPHRESLPGLSSTATPGNPALYSR 1004
+ M + HR+ GL+ST Y R
Sbjct: 872 WIILMVFSIWLYRHRKKRNGLTSTYAGIRKVTYQR 906
Score = 137 bits (346), Expect = 5e-32
Identities = 160/679 (23%), Positives = 261/679 (38%), Gaps = 91/679 (13%)
Query: 42 PLQVILGPEQAAVLNCSLGAAAAGPPTRVTWSKDGDTLLEHDHLHLLPNGSLWLSQPLAP 101
P V++ + AV+ C P ++W KDG L + D + G L ++
Sbjct: 137 PSDVMVAVGEPAVMECQ--PPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKS 194
Query: 102 NGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTAR 161
+ G Y C+ +G S+ A + + F P + V + +A
Sbjct: 195 DA-------------GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE 241
Query: 162 FECHIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQH 221
F+C G P P + W KD LP+ R + + L+I V D G Y CVA N +
Sbjct: 242 FKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300
Query: 222 FSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQD 281
+ L + V P + V G++V +C A+ +P P + W R+
Sbjct: 301 EASATLT--------VQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREG 352
Query: 282 GK--------PISTDVIVLGRT-NLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVL 332
+ P S+ + +T +L I N Q G Y+C+ A E+ +
Sbjct: 353 SQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV 412
Query: 333 AA----PAITQAPEALSRTRASTARFV--CRASGEPRPALRWLHNGAPLRPNGRVKVQGG 386
A P I Q P +++T A FV C A+G P P + W +G + Q
Sbjct: 413 IADRPPPVIRQGP--VNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLE 470
Query: 387 GGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAV------------VVREGLPSAPTR 434
G L I L D G Y C+A +G A +A + V +PSAP++
Sbjct: 471 NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSK 530
Query: 435 VTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLE 494
T +S + V ++W+ P ++S + + + A N T ++ L+
Sbjct: 531 PEVTDVSRNTVTLSWQ-PNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLK 589
Query: 495 PNTDYEFYVVAYSQLGASRTSTPA-LVHTLDDVPSAA-------------PQLSLSSP-- 538
PN Y F V A + G S S + V T D +P++ L L +P
Sbjct: 590 PNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTV 649
Query: 539 -NPSDIRVAWLPLPPSLSNGQVVKYKIEY-----GLGKEDQIFSTEVRGNETQLMLNSLQ 592
+ S I V W + + YKI Y G+ D + + +++ L+
Sbjct: 650 LSSSSIEVHWTV---DQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLR 706
Query: 593 PNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQAKME----SLVVS 648
Y ++ GA S+ +T P AP + +K + +++VS
Sbjct: 707 KGVNYEIKARPFFNEFQGADSEIKFAKT-----LEEAPSAPPQGVTVSKNDGNGTAILVS 761
Query: 649 WQPPPHPTQ---ISGYKLY 664
WQPPP TQ + YK++
Sbjct: 762 WQPPPEDTQNGMVQEYKVW 780
Score = 59.7 bits (143), Expect = 2e-08
Identities = 52/207 (25%), Positives = 77/207 (37%), Gaps = 16/207 (7%)
Query: 246 IVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTDVIVLGRTNLLIANAQPW 305
IV P + V G+ + C A PTP + W + G+ + TD +L+ + +
Sbjct: 31 IVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLF 89
Query: 306 ------------HSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTAR 353
GVYVC A + A+ + Q P + A
Sbjct: 90 FLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAV 149
Query: 354 FVCR-ASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAG 412
C+ G P P + W +G+PL ++ GG L+IT DAG Y CV N G
Sbjct: 150 MECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKSDAGKYVCVGTNMVG 208
Query: 413 -MACAAASLAVVVREGLPSAPTRVTAT 438
A L V+ R P+ + T
Sbjct: 209 ERESEVAELTVLERPSFVKRPSNLAVT 235
Score = 39.7 bits (91), Expect = 0.018
Identities = 45/176 (25%), Positives = 70/176 (39%), Gaps = 28/176 (15%)
Query: 302 AQPWHSGVY----VCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTARFVCR 357
A+P H ++ +C ++ R DF P I + P L ++ A C+
Sbjct: 3 AEPAHFYLFGLICLCSGSRLRQEDFP-----------PRIVEHPSDLIVSKGEPATLNCK 51
Query: 358 ASGEPRPALRWLHNGAPLRPN----GRVKVQGGGGSLVITQI-----GLQDAGYYQCVAE 408
A G P P + W G + + ++ GSL +I D G Y CVA
Sbjct: 52 AEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVAR 111
Query: 409 NSAGMACA-AASLAV-VVREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGF 462
N G A + ASL V ++R+ P+ V + AV+ + P H E I +
Sbjct: 112 NYLGEAVSHNASLEVAILRDDFRQNPSDVMVA-VGEPAVMEC-QPPRGHPEPTISW 165
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 162 bits (410), Expect = 2e-39
Identities = 200/786 (25%), Positives = 304/786 (38%), Gaps = 109/786 (13%)
Query: 42 PLQVILGPEQAAVLNCSLGAAAAGPPT-RVTWSKDGDTLLE-----HDHLHLLPNGSLWL 95
P +I+ + A LNC A G PT + W K G+ + H LLP+GSL+
Sbjct: 35 PSDLIVSKGEPATLNCK----AEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF 90
Query: 96 SQPLAPNGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLAD-FSLHPESQTV 154
+ + +S P+ EG Y C+A LG S A +++A L D F +P V
Sbjct: 91 LRIVHGR---KSRPD-----EGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 142
Query: 155 EENGTARFECHI-EGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCV 213
A EC G P P I+W+KD L ++ I + G L I ++SDAG Y CV
Sbjct: 143 AVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCV 202
Query: 214 ATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTP 273
TN + S+ A L+V R S V P N V S +C A DP P
Sbjct: 203 GTNMVGERESEVAELTVLERPS----------FVKRPSNLAVTVDDSAEFKCEARGDPVP 252
Query: 274 FVSWVRQDGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLA 333
V W + DG+ + + L I G Y C A + A+A ++V +
Sbjct: 253 TVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGS 312
Query: 334 APA-ITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGA--------PLRPNGRVKVQ 384
P P T F C A+G P+PA+ W G+ P + + R V
Sbjct: 313 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSV- 371
Query: 385 GGGGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAV----------VVREGLPSAPTR 434
G L IT + D GYY C N AG A L V V+R+G +
Sbjct: 372 SQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVA 431
Query: 435 VTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDN--VEYQFAVNNDTTELQVRD 492
V T + S + + + + S + + ++N ++ ++A DT
Sbjct: 432 VDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIA 491
Query: 493 LEPNTDYEFYV-VAYSQLGA----SRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVAW 547
P+ + + + + G R + P L +PSA + ++ + + + ++W
Sbjct: 492 STPSGEATWSAYIEVQEFGVPVQPPRPTDPNL------IPSAPSKPEVTDVSRNTVTLSW 545
Query: 548 LPLPPSLSNGQV-VKYKIE---YGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISA 603
P+L++G Y IE + G Q + V+ ET + L+PN +Y + A
Sbjct: 546 ---QPNLNSGATPTSYIIEAFSHASGSSWQTVAENVK-TETS-AIKGLKPNAIYLFLVRA 600
Query: 604 GTAAGFGAPSQWMHH-RTPSM--------HNQSHVPFAPAELKVQ----AKMESLVVSWQ 650
A G PSQ +T + H Q A L + S+ V W
Sbjct: 601 ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 660
Query: 651 PPPHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPG 710
I GYK+ +R GA G+ W V VR K + L G
Sbjct: 661 VDQQSQYIQGYKILYRPSGA-----------NHGESDWLVFEVRTPAK-NSVVIPDLRKG 708
Query: 711 RLYEVKL-VAFNKHEDGYAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESN--SSTSIW 767
YE+K FN+ + + + KT ++ P PP V N + T+I
Sbjct: 709 VNYEIKARPFFNEFQGADSEIKFAKT---------LEEAPSAPPQGVTVSKNDGNGTAIL 759
Query: 768 LRWKKP 773
+ W+ P
Sbjct: 760 VSWQPP 765
Score = 139 bits (351), Expect = 1e-32
Identities = 224/924 (24%), Positives = 350/924 (37%), Gaps = 140/924 (15%)
Query: 148 HPESQTVEENGTARFECHIEGLPAPIITWEK--DQV-TLPEEPR--LIVLPNGVLQILDV 202
HP V + A C EG P P I W K ++V T ++PR ++LP+G L L +
Sbjct: 34 HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRI 93
Query: 203 -----QESDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVS 257
D G Y CVA N + S A L VA L Q+ P + V
Sbjct: 94 VHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVA---ILRDDFRQN------PSDVMVAV 144
Query: 258 GQSVVMEC-VASADPTPFVSWVRQDGKPI--STDVIVLGRTNLLIANAQPWHSGVYVCRA 314
G+ VMEC P P +SW ++DG P+ + I + L+I + +G YVC
Sbjct: 145 GEPAVMECQPPRGHPEPTISW-KKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC-V 202
Query: 315 NKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAP 374
+ + AEL VL P+ + P L+ T +A F C A G+P P +RW +
Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 262
Query: 375 LRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAVVVREGLPSAPTR 434
L P R +++ +L I ++ D G Y CVAEN G A A+A+L V V S P
Sbjct: 263 L-PKSRYEIR-DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV----GSEPPH 316
Query: 435 VTATPLSSSAVL-----------------VAWERPEMHSEQIIGFSLHYQKARGMDNVEY 477
P L + W R Q + FS YQ +
Sbjct: 317 FVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRR---EGSQNLLFS--YQPPQSSS---- 367
Query: 478 QFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSS 537
+F+V + T +L + +++ +D +Y+ + S T A + D + P +
Sbjct: 368 RFSV-SQTGDLTITNVQ-RSDVGYYICQTLNVAGS-IITKAYLEVTDVIADRPPPVIRQG 424
Query: 538 PNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQ----- 592
P + V + ++ G V L ++D + + QL LQ
Sbjct: 425 PVNQTVAVDGTFVLSCVATGSPVPTI----LWRKDGVLVSTQDSRIKQLENGVLQIRYAK 480
Query: 593 PNKVYRVRISAGTAAG------------FGAPSQWMHHRTPSMHNQSHVPFAPAELKV-Q 639
R A T +G FG P Q P++ +P AP++ +V
Sbjct: 481 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNL-----IPSAPSKPEVTD 535
Query: 640 AKMESLVVSWQPPPHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKV 699
++ +SWQP + SG + A A+G +W V K
Sbjct: 536 VSRNTVTLSWQPNLN----SGATPTSYIIEAFSHASG---------SSWQT--VAENVKT 580
Query: 700 KQYELTQLVPGRLYEVKLVAFNKH--EDGYAAVWKGKTE-----KAPAPDMPIQRGPPLP 752
+ + L P +Y + A N + D KT+ +QR
Sbjct: 581 ETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNA 640
Query: 753 PAHVHAES-NSSTSIWLRWKKPDFTTVKIVNYTVRFSPWGLRNAS----LVTYYTSSGED 807
H+H + SS+SI + W D + I Y + + P G + + T +
Sbjct: 641 VLHLHNPTVLSSSSIEVHW-TVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNS 699
Query: 808 ILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRLSPL--TPSTVR 865
++I L+ YE + + G + TL + PS PP + +S + +
Sbjct: 700 VVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAIL 759
Query: 866 LHWCPPTE--PNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESDTRYFFKM 923
+ W PP E NG + EY + N T+ T G+ FS + L RY ++
Sbjct: 760 VSWQPPPEDTQNGMVQEYKVWCLGNETRYHIN---KTVDGSTFSVVIPFLVPGIRYSVEV 816
Query: 924 GARTEVGPGPFSRLQ--------------DVITLQEKLSDSLDMHSVTGIIVGVCLGLLC 969
A T G G S Q D ++L +++SD + I G+ G C
Sbjct: 817 AASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQ---PAFIAGI--GAAC 871
Query: 970 LLACMCAGLRRSPHRESLPGLSST 993
+ M + HR+ GL+ST
Sbjct: 872 WIILMVFSIWLYRHRKKRNGLTST 895
Score = 137 bits (346), Expect = 5e-32
Identities = 160/679 (23%), Positives = 261/679 (38%), Gaps = 91/679 (13%)
Query: 42 PLQVILGPEQAAVLNCSLGAAAAGPPTRVTWSKDGDTLLEHDHLHLLPNGSLWLSQPLAP 101
P V++ + AV+ C P ++W KDG L + D + G L ++
Sbjct: 137 PSDVMVAVGEPAVMECQ--PPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKS 194
Query: 102 NGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTAR 161
+ G Y C+ +G S+ A + + F P + V + +A
Sbjct: 195 DA-------------GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE 241
Query: 162 FECHIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQH 221
F+C G P P + W KD LP+ R + + L+I V D G Y CVA N +
Sbjct: 242 FKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300
Query: 222 FSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQD 281
+ L + V P + V G++V +C A+ +P P + W R+
Sbjct: 301 EASATLT--------VQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREG 352
Query: 282 GK--------PISTDVIVLGRT-NLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVL 332
+ P S+ + +T +L I N Q G Y+C+ A E+ +
Sbjct: 353 SQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV 412
Query: 333 AA----PAITQAPEALSRTRASTARFV--CRASGEPRPALRWLHNGAPLRPNGRVKVQGG 386
A P I Q P +++T A FV C A+G P P + W +G + Q
Sbjct: 413 IADRPPPVIRQGP--VNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLE 470
Query: 387 GGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAV------------VVREGLPSAPTR 434
G L I L D G Y C+A +G A +A + V +PSAP++
Sbjct: 471 NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSK 530
Query: 435 VTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLE 494
T +S + V ++W+ P ++S + + + A N T ++ L+
Sbjct: 531 PEVTDVSRNTVTLSWQ-PNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLK 589
Query: 495 PNTDYEFYVVAYSQLGASRTSTPA-LVHTLDDVPSAA-------------PQLSLSSP-- 538
PN Y F V A + G S S + V T D +P++ L L +P
Sbjct: 590 PNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTV 649
Query: 539 -NPSDIRVAWLPLPPSLSNGQVVKYKIEY-----GLGKEDQIFSTEVRGNETQLMLNSLQ 592
+ S I V W + + YKI Y G+ D + + +++ L+
Sbjct: 650 LSSSSIEVHWTV---DQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLR 706
Query: 593 PNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQAKME----SLVVS 648
Y ++ GA S+ +T P AP + +K + +++VS
Sbjct: 707 KGVNYEIKARPFFNEFQGADSEIKFAKT-----LEEAPSAPPQGVTVSKNDGNGTAILVS 761
Query: 649 WQPPPHPTQ---ISGYKLY 664
WQPPP TQ + YK++
Sbjct: 762 WQPPPEDTQNGMVQEYKVW 780
Score = 59.7 bits (143), Expect = 2e-08
Identities = 52/207 (25%), Positives = 77/207 (37%), Gaps = 16/207 (7%)
Query: 246 IVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTDVIVLGRTNLLIANAQPW 305
IV P + V G+ + C A PTP + W + G+ + TD +L+ + +
Sbjct: 31 IVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLF 89
Query: 306 ------------HSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTAR 353
GVYVC A + A+ + Q P + A
Sbjct: 90 FLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAV 149
Query: 354 FVCR-ASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAG 412
C+ G P P + W +G+PL ++ GG L+IT DAG Y CV N G
Sbjct: 150 MECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKSDAGKYVCVGTNMVG 208
Query: 413 -MACAAASLAVVVREGLPSAPTRVTAT 438
A L V+ R P+ + T
Sbjct: 209 ERESEVAELTVLERPSFVKRPSNLAVT 235
Score = 39.7 bits (91), Expect = 0.018
Identities = 45/176 (25%), Positives = 70/176 (39%), Gaps = 28/176 (15%)
Query: 302 AQPWHSGVY----VCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTARFVCR 357
A+P H ++ +C ++ R DF P I + P L ++ A C+
Sbjct: 3 AEPAHFYLFGLICLCSGSRLRQEDFP-----------PRIVEHPSDLIVSKGEPATLNCK 51
Query: 358 ASGEPRPALRWLHNGAPLRPN----GRVKVQGGGGSLVITQI-----GLQDAGYYQCVAE 408
A G P P + W G + + ++ GSL +I D G Y CVA
Sbjct: 52 AEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVAR 111
Query: 409 NSAGMACA-AASLAV-VVREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGF 462
N G A + ASL V ++R+ P+ V + AV+ + P H E I +
Sbjct: 112 NYLGEAVSHNASLEVAILRDDFRQNPSDVMVA-VGEPAVMEC-QPPRGHPEPTISW 165
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 162 bits (410), Expect = 2e-39
Identities = 200/786 (25%), Positives = 304/786 (38%), Gaps = 109/786 (13%)
Query: 42 PLQVILGPEQAAVLNCSLGAAAAGPPT-RVTWSKDGDTLLE-----HDHLHLLPNGSLWL 95
P +I+ + A LNC A G PT + W K G+ + H LLP+GSL+
Sbjct: 35 PSDLIVSKGEPATLNCK----AEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF 90
Query: 96 SQPLAPNGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLAD-FSLHPESQTV 154
+ + +S P+ EG Y C+A LG S A +++A L D F +P V
Sbjct: 91 LRIVHGR---KSRPD-----EGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 142
Query: 155 EENGTARFECHI-EGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCV 213
A EC G P P I+W+KD L ++ I + G L I ++SDAG Y CV
Sbjct: 143 AVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCV 202
Query: 214 ATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTP 273
TN + S+ A L+V R S V P N V S +C A DP P
Sbjct: 203 GTNMVGERESEVAELTVLERPS----------FVKRPSNLAVTVDDSAEFKCEARGDPVP 252
Query: 274 FVSWVRQDGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLA 333
V W + DG+ + + L I G Y C A + A+A ++V +
Sbjct: 253 TVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGS 312
Query: 334 APA-ITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGA--------PLRPNGRVKVQ 384
P P T F C A+G P+PA+ W G+ P + + R V
Sbjct: 313 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSV- 371
Query: 385 GGGGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAV----------VVREGLPSAPTR 434
G L IT + D GYY C N AG A L V V+R+G +
Sbjct: 372 SQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVA 431
Query: 435 VTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDN--VEYQFAVNNDTTELQVRD 492
V T + S + + + + S + + ++N ++ ++A DT
Sbjct: 432 VDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIA 491
Query: 493 LEPNTDYEFYV-VAYSQLGA----SRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVAW 547
P+ + + + + G R + P L +PSA + ++ + + + ++W
Sbjct: 492 STPSGEATWSAYIEVQEFGVPVQPPRPTDPNL------IPSAPSKPEVTDVSRNTVTLSW 545
Query: 548 LPLPPSLSNGQV-VKYKIE---YGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISA 603
P+L++G Y IE + G Q + V+ ET + L+PN +Y + A
Sbjct: 546 ---QPNLNSGATPTSYIIEAFSHASGSSWQTVAENVK-TETS-AIKGLKPNAIYLFLVRA 600
Query: 604 GTAAGFGAPSQWMHH-RTPSM--------HNQSHVPFAPAELKVQ----AKMESLVVSWQ 650
A G PSQ +T + H Q A L + S+ V W
Sbjct: 601 ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 660
Query: 651 PPPHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPG 710
I GYK+ +R GA G+ W V VR K + L G
Sbjct: 661 VDQQSQYIQGYKILYRPSGA-----------NHGESDWLVFEVRTPAK-NSVVIPDLRKG 708
Query: 711 RLYEVKL-VAFNKHEDGYAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESN--SSTSIW 767
YE+K FN+ + + + KT ++ P PP V N + T+I
Sbjct: 709 VNYEIKARPFFNEFQGADSEIKFAKT---------LEEAPSAPPQGVTVSKNDGNGTAIL 759
Query: 768 LRWKKP 773
+ W+ P
Sbjct: 760 VSWQPP 765
Score = 139 bits (351), Expect = 1e-32
Identities = 224/924 (24%), Positives = 350/924 (37%), Gaps = 140/924 (15%)
Query: 148 HPESQTVEENGTARFECHIEGLPAPIITWEK--DQV-TLPEEPR--LIVLPNGVLQILDV 202
HP V + A C EG P P I W K ++V T ++PR ++LP+G L L +
Sbjct: 34 HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRI 93
Query: 203 -----QESDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVS 257
D G Y CVA N + S A L VA L Q+ P + V
Sbjct: 94 VHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVA---ILRDDFRQN------PSDVMVAV 144
Query: 258 GQSVVMEC-VASADPTPFVSWVRQDGKPI--STDVIVLGRTNLLIANAQPWHSGVYVCRA 314
G+ VMEC P P +SW ++DG P+ + I + L+I + +G YVC
Sbjct: 145 GEPAVMECQPPRGHPEPTISW-KKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC-V 202
Query: 315 NKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAP 374
+ + AEL VL P+ + P L+ T +A F C A G+P P +RW +
Sbjct: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 262
Query: 375 LRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAVVVREGLPSAPTR 434
L P R +++ +L I ++ D G Y CVAEN G A A+A+L V V S P
Sbjct: 263 L-PKSRYEIR-DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV----GSEPPH 316
Query: 435 VTATPLSSSAVL-----------------VAWERPEMHSEQIIGFSLHYQKARGMDNVEY 477
P L + W R Q + FS YQ +
Sbjct: 317 FVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRR---EGSQNLLFS--YQPPQSSS---- 367
Query: 478 QFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSS 537
+F+V + T +L + +++ +D +Y+ + S T A + D + P +
Sbjct: 368 RFSV-SQTGDLTITNVQ-RSDVGYYICQTLNVAGS-IITKAYLEVTDVIADRPPPVIRQG 424
Query: 538 PNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQ----- 592
P + V + ++ G V L ++D + + QL LQ
Sbjct: 425 PVNQTVAVDGTFVLSCVATGSPVPTI----LWRKDGVLVSTQDSRIKQLENGVLQIRYAK 480
Query: 593 PNKVYRVRISAGTAAG------------FGAPSQWMHHRTPSMHNQSHVPFAPAELKV-Q 639
R A T +G FG P Q P++ +P AP++ +V
Sbjct: 481 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNL-----IPSAPSKPEVTD 535
Query: 640 AKMESLVVSWQPPPHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKV 699
++ +SWQP + SG + A A+G +W V K
Sbjct: 536 VSRNTVTLSWQPNLN----SGATPTSYIIEAFSHASG---------SSWQT--VAENVKT 580
Query: 700 KQYELTQLVPGRLYEVKLVAFNKH--EDGYAAVWKGKTE-----KAPAPDMPIQRGPPLP 752
+ + L P +Y + A N + D KT+ +QR
Sbjct: 581 ETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNA 640
Query: 753 PAHVHAES-NSSTSIWLRWKKPDFTTVKIVNYTVRFSPWGLRNAS----LVTYYTSSGED 807
H+H + SS+SI + W D + I Y + + P G + + T +
Sbjct: 641 VLHLHNPTVLSSSSIEVHW-TVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNS 699
Query: 808 ILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRLSPL--TPSTVR 865
++I L+ YE + + G + TL + PS PP + +S + +
Sbjct: 700 VVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAIL 759
Query: 866 LHWCPPTE--PNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESDTRYFFKM 923
+ W PP E NG + EY + N T+ T G+ FS + L RY ++
Sbjct: 760 VSWQPPPEDTQNGMVQEYKVWCLGNETRYHIN---KTVDGSTFSVVIPFLVPGIRYSVEV 816
Query: 924 GARTEVGPGPFSRLQ--------------DVITLQEKLSDSLDMHSVTGIIVGVCLGLLC 969
A T G G S Q D ++L +++SD + I G+ G C
Sbjct: 817 AASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQ---PAFIAGI--GAAC 871
Query: 970 LLACMCAGLRRSPHRESLPGLSST 993
+ M + HR+ GL+ST
Sbjct: 872 WIILMVFSIWLYRHRKKRNGLTST 895
Score = 137 bits (346), Expect = 5e-32
Identities = 160/679 (23%), Positives = 261/679 (38%), Gaps = 91/679 (13%)
Query: 42 PLQVILGPEQAAVLNCSLGAAAAGPPTRVTWSKDGDTLLEHDHLHLLPNGSLWLSQPLAP 101
P V++ + AV+ C P ++W KDG L + D + G L ++
Sbjct: 137 PSDVMVAVGEPAVMECQ--PPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKS 194
Query: 102 NGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTAR 161
+ G Y C+ +G S+ A + + F P + V + +A
Sbjct: 195 DA-------------GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE 241
Query: 162 FECHIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQH 221
F+C G P P + W KD LP+ R + + L+I V D G Y CVA N +
Sbjct: 242 FKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300
Query: 222 FSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQD 281
+ L + V P + V G++V +C A+ +P P + W R+
Sbjct: 301 EASATLT--------VQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREG 352
Query: 282 GK--------PISTDVIVLGRT-NLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVL 332
+ P S+ + +T +L I N Q G Y+C+ A E+ +
Sbjct: 353 SQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV 412
Query: 333 AA----PAITQAPEALSRTRASTARFV--CRASGEPRPALRWLHNGAPLRPNGRVKVQGG 386
A P I Q P +++T A FV C A+G P P + W +G + Q
Sbjct: 413 IADRPPPVIRQGP--VNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLE 470
Query: 387 GGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAV------------VVREGLPSAPTR 434
G L I L D G Y C+A +G A +A + V +PSAP++
Sbjct: 471 NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSK 530
Query: 435 VTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLE 494
T +S + V ++W+ P ++S + + + A N T ++ L+
Sbjct: 531 PEVTDVSRNTVTLSWQ-PNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLK 589
Query: 495 PNTDYEFYVVAYSQLGASRTSTPA-LVHTLDDVPSAA-------------PQLSLSSP-- 538
PN Y F V A + G S S + V T D +P++ L L +P
Sbjct: 590 PNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTV 649
Query: 539 -NPSDIRVAWLPLPPSLSNGQVVKYKIEY-----GLGKEDQIFSTEVRGNETQLMLNSLQ 592
+ S I V W + + YKI Y G+ D + + +++ L+
Sbjct: 650 LSSSSIEVHWTV---DQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLR 706
Query: 593 PNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQAKME----SLVVS 648
Y ++ GA S+ +T P AP + +K + +++VS
Sbjct: 707 KGVNYEIKARPFFNEFQGADSEIKFAKT-----LEEAPSAPPQGVTVSKNDGNGTAILVS 761
Query: 649 WQPPPHPTQ---ISGYKLY 664
WQPPP TQ + YK++
Sbjct: 762 WQPPPEDTQNGMVQEYKVW 780
Score = 59.7 bits (143), Expect = 2e-08
Identities = 52/207 (25%), Positives = 77/207 (37%), Gaps = 16/207 (7%)
Query: 246 IVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTDVIVLGRTNLLIANAQPW 305
IV P + V G+ + C A PTP + W + G+ + TD +L+ + +
Sbjct: 31 IVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLF 89
Query: 306 ------------HSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTAR 353
GVYVC A + A+ + Q P + A
Sbjct: 90 FLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAV 149
Query: 354 FVCR-ASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAG 412
C+ G P P + W +G+PL ++ GG L+IT DAG Y CV N G
Sbjct: 150 MECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKSDAGKYVCVGTNMVG 208
Query: 413 -MACAAASLAVVVREGLPSAPTRVTAT 438
A L V+ R P+ + T
Sbjct: 209 ERESEVAELTVLERPSFVKRPSNLAVT 235
Score = 39.7 bits (91), Expect = 0.018
Identities = 45/176 (25%), Positives = 70/176 (39%), Gaps = 28/176 (15%)
Query: 302 AQPWHSGVY----VCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTARFVCR 357
A+P H ++ +C ++ R DF P I + P L ++ A C+
Sbjct: 3 AEPAHFYLFGLICLCSGSRLRQEDFP-----------PRIVEHPSDLIVSKGEPATLNCK 51
Query: 358 ASGEPRPALRWLHNGAPLRPN----GRVKVQGGGGSLVITQI-----GLQDAGYYQCVAE 408
A G P P + W G + + ++ GSL +I D G Y CVA
Sbjct: 52 AEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVAR 111
Query: 409 NSAGMACA-AASLAV-VVREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGF 462
N G A + ASL V ++R+ P+ V + AV+ + P H E I +
Sbjct: 112 NYLGEAVSHNASLEVAILRDDFRQNPSDVMVA-VGEPAVMEC-QPPRGHPEPTISW 165
>gi|81158226 neuronal cell adhesion molecule isoform A precursor [Homo
sapiens]
Length = 1304
Score = 160 bits (405), Expect = 7e-39
Identities = 209/827 (25%), Positives = 324/827 (39%), Gaps = 111/827 (13%)
Query: 163 ECHIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHF 222
EC EGLP PII W K+ LP+ + LQI+ V E+D+G Y+C+A N
Sbjct: 291 ECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKN------ 344
Query: 223 SQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDG 282
AL ++ H S+ + AP+N + G+ + C A+ +P P +SW+ +G
Sbjct: 345 ---ALGAIHHTISVRVKAAP--YWITAPQNLVLSPGEDGTLICRANGNPKPRISWL-TNG 398
Query: 283 KPISTDVIVLGR----TNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAP--A 336
PI R ++ +N Q S VY C A+ + A A + VLA P
Sbjct: 399 VPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNAS--NEYGYLLANAFVNVLAEPPRI 456
Query: 337 ITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIG 396
+T A A C G P P + W + + V G+L I
Sbjct: 457 LTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQ 516
Query: 397 LQDAGYYQCVAENSAGMACAAASLAVVVREGLPSAPTRVTATP---LSSSAVLVAWERPE 453
G Y CVA N GMA L + PT + P + +V++E
Sbjct: 517 KDSTGTYTCVARNKLGMAKNEVHLEI-------KDPTWIVKQPEYAVVQRGSMVSFECKV 569
Query: 454 MHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGA-- 511
H + L + R + + E +F V+ D L V D+ + + VA + L +
Sbjct: 570 KHDHTLSLTVLWLKDNRELPSDE-RFTVDKD--HLVVADVSDDDSGTYTCVANTTLDSVS 626
Query: 512 --------SRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYK 563
+ T TPA V+ DVP+ L L+ ++++W P +N + K+
Sbjct: 627 ASAVLSVVAPTPTPAPVY---DVPNPPFDLELTDQLDKSVQLSW--TPGDDNNSPITKFI 681
Query: 564 IEYGLGKEDQI-------FSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWM 616
IEY ED + TEV G +T L L P Y R+ A + G PS+
Sbjct: 682 IEY----EDAMHKPGLWHHQTEVSGTQTTAQL-KLSPYVNYSFRVMAVNSIGKSLPSEAS 736
Query: 617 HHRTPSMHNQSHVPFAPAELKVQAKMESLVVSWQPPPHPTQISG----YKLYWREVGAEE 672
P A L ++ ++LV++W+ P + + +G YK+ WR+
Sbjct: 737 EQYLTKASEPDKNPTAVEGL--GSEPDNLVITWK-PLNGFESNGPGLQYKVSWRQKD--- 790
Query: 673 EANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYA---A 729
GD W V K VP Y +K+ A N + G+A A
Sbjct: 791 -----------GDDEWTSVVVANVSKYIVSGTPTFVP---YLIKVQALN--DMGFAPEPA 834
Query: 730 VWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRFSP 789
V G + D+P+ + P +V +ST + W +++ R
Sbjct: 835 VVMGHS----GEDLPM-----VAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYY 885
Query: 790 WGLRNAS----------LVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVE 839
W +++S ++T+ S +L GL+PF+ Y V+ +GP S
Sbjct: 886 WKTQSSSKRNRRHIEKKILTFQGSKTHGML-PGLEPFSHYTLNVRVVNGKGEGP-ASPDR 943
Query: 840 RSTLPDRPSTPPSDLRLSPLTPSTVRLHWCPPTEPNGEIVEYLILYSS-NHTQPEHQWTL 898
P+ + PS L++ T ++ L W PP+ PNG + EY + Y N T
Sbjct: 944 VFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGILTEYTLKYQPINSTHELGPLVD 1003
Query: 899 LTTQGNIFSAEVHGLESDTRYFFKMGARTEVGPGPFSRLQDVITLQE 945
L N + L TRY F A+T G G + V T+ E
Sbjct: 1004 LKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITEEAVTTVDE 1050
Score = 103 bits (256), Expect = 1e-21
Identities = 126/509 (24%), Positives = 204/509 (40%), Gaps = 63/509 (12%)
Query: 42 PLQVILGPEQAAVLNCSLGAAAAGPPTRVTWSKDGDTL-LEHDHLHLLPNGSLWLSQPLA 100
P I+ P + V+ C A PP +W+++G ++ D L + G+ L +
Sbjct: 53 PKDYIIDPRENIVIQCE---AKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIM 109
Query: 101 PNGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLADFSLHP-ESQTVEENGT 159
G E+ EG Y C A G S VV+ + ++ E T++ +
Sbjct: 110 SEGKAETY-------EGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQS 162
Query: 160 ARFECHIE-GLPAPIITWEKDQVT-LPEEPRLIVLPNGVLQILDVQESDAGP-YRCVATN 216
C GLP PII W + LP+ R+ NG L +V D Y C A
Sbjct: 163 LVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARF 222
Query: 217 SARQHFSQEA-----LLSVAHRGSLASTRGQDVVIVAA------------PE----NTTV 255
+ Q Q+ ++SV + D A PE N
Sbjct: 223 NHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEE 282
Query: 256 VSGQSVVMECVASADPTPFVSWVRQDGK-PISTDVIVLGRTNLLIANAQPWHSGVYVCRA 314
+ G + +EC+A PTP + W ++DG P + V L I + SG Y C A
Sbjct: 283 LRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIA 342
Query: 315 NKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAP 374
T + +RV AAP AP+ L + +CRA+G P+P + WL NG P
Sbjct: 343 KNALGAIHHTIS--VRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVP 400
Query: 375 LR-----PNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAVVVREGLP 429
+ P+ ++ G +++ + + + + YQC A N G A A + V+
Sbjct: 401 IEIAPDDPSRKI----DGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVL------ 450
Query: 430 SAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSL----HYQKARGMDNVEYQFAVN-ND 484
+ P R+ TP ++ ++A RP + G L ++ A+G E + ++ N
Sbjct: 451 AEPPRI-LTPANTLYQVIA-NRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENG 508
Query: 485 TTELQVRDLEPNTDYEFYVVAYSQLGASR 513
T E+ V + Y VA ++LG ++
Sbjct: 509 TLEIPVAQKDSTGTYT--CVARNKLGMAK 535
Score = 57.0 bits (136), Expect = 1e-07
Identities = 47/213 (22%), Positives = 90/213 (42%), Gaps = 12/213 (5%)
Query: 409 NSAGMACAAASLAVVVREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQK 468
N G A+ EG+PSAP+ + + ++ + W+ P + + ++L YQ
Sbjct: 932 NGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGILTEYTLKYQP 991
Query: 469 ARGMDNVE--YQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDV 526
+ + + T +++L +T Y+FY A + G+ T V T+D+
Sbjct: 992 INSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITEEAVTTVDEA 1051
Query: 527 PSAAPQLSLS-----SPNPSDIRVAWLPLPPSLS----NGQVVKYKIEYGL-GKEDQIFS 576
P + +P S++ A ++S + V + +EYG+ G +++
Sbjct: 1052 GILPPDVGAGKVQAVNPRISNLTAAAAETYANISWEYEGPEHVNFYVEYGVAGSKEEWRK 1111
Query: 577 TEVRGNETQLMLNSLQPNKVYRVRISAGTAAGF 609
V G+ + L L P Y+VR+ A +GF
Sbjct: 1112 EIVNGSRSFFGLKGLMPGTAYKVRVGAVGDSGF 1144
Score = 53.9 bits (128), Expect = 9e-07
Identities = 49/181 (27%), Positives = 75/181 (41%), Gaps = 22/181 (12%)
Query: 53 AVLNCSLGAAAAGPPTRVTWSKDGDTLLEHDHLHLL-PNGSLWLSQPLAPNGSDESVPEA 111
A+L+C A P + W K H+ +++L NG+L +P A
Sbjct: 472 ALLDC---AFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTL-------------EIPVA 515
Query: 112 VGVIEGNYSCLAHGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTARFECHI--EGL 169
G Y+C+A LG +A +++ PE V+ FEC + +
Sbjct: 516 QKDSTGTYTCVARNKLG-MAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHT 574
Query: 170 PAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEALLS 229
+ + W KD LP + R V L + DV + D+G Y CVA N+ S A+LS
Sbjct: 575 LSLTVLWLKDNRELPSDERFTV-DKDHLVVADVSDDDSGTYTCVA-NTTLDSVSASAVLS 632
Query: 230 V 230
V
Sbjct: 633 V 633
Score = 39.3 bits (90), Expect = 0.024
Identities = 37/165 (22%), Positives = 62/165 (37%), Gaps = 19/165 (11%)
Query: 249 APENTTVVSGQSVVMECVASADPTPFVSWVRQ------DGKPISTDVIVLGR--TNLLIA 300
+P++ + +++V++C A P P SW R D P+ T G N++
Sbjct: 52 SPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMSE 111
Query: 301 NAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPA-----ITQAPEALSRTRASTARFV 355
+ GVY C A R AA ++ P+ + E ++ +
Sbjct: 112 GKAETYEGVYQCTARNER-----GAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLP 166
Query: 356 CRAS-GEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQD 399
CR G P P + W+ N P QG G L + + +D
Sbjct: 167 CRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPED 211
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 159 bits (403), Expect = 1e-38
Identities = 176/707 (24%), Positives = 288/707 (40%), Gaps = 83/707 (11%)
Query: 145 FSLHPESQTVEENGTARFECHIEGLPAPIITW-EKDQVTLPEEPRLIVLPNGVLQILDVQ 203
F P+ Q G A F C G P P +TW +K + + I +L +Q
Sbjct: 35 FIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQ 94
Query: 204 ----ESDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQ 259
D Y CVA NS + + A L+V L S I P+ V +
Sbjct: 95 PLRTPRDENVYECVAQNSVGE-ITVHAKLTVLREDQLPSGFPN---IDMGPQLKVVERTR 150
Query: 260 SVVMECVASADPTPFVSWVRQ----DGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRA- 314
+ M C AS +P P ++W + D + + L L I +++ G Y C A
Sbjct: 151 TATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECVAT 210
Query: 315 NKPRTRDFATAAAELRV-LAAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGA 373
N R + A +RV AP + P + C A G P P ++W+
Sbjct: 211 NSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAE 270
Query: 374 PLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAVVVREGLPSAPT 433
L P + V G V+ ++D+ Y CVA +S G+ A A + V + LP AP
Sbjct: 271 DLTPEDDMPV----GRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV---KSLPKAPG 323
Query: 434 RVTATPLSSSAVLVAWE--RPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVR 491
T +++++ + W+ P+ S +I + K++ D YQ + TT +
Sbjct: 324 TPMVTENTATSITITWDSGNPDPVSYYVIEY-----KSKSQDG-PYQIKEDITTTRYSIG 377
Query: 492 DLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQ-LSLSSPNPSDIRVAW-LP 549
L PN++YE +V A + +G S + T + P++AP+ + + + + V W P
Sbjct: 378 GLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEP 437
Query: 550 LPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGNETQLM--LNSLQPNKVYRVRISAGTAA 607
+ P NG + Y++ Y + E + + + + L+ + SL ++ Y VR+ A T+
Sbjct: 438 VEP---NGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSV 494
Query: 608 GFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQAKME-SLVVSWQPPPHPTQISGYKLYWR 666
G G S + +T Q VP P L+ +A+ E S+ +SW PP + I Y+L +R
Sbjct: 495 GDGPLSDPIQVKT-----QQGVPGQPMNLRAEARSETSITLSWSPPRQESIIK-YELLFR 548
Query: 667 EVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDG 726
E GD +VG R Y + L P Y +L A + G
Sbjct: 549 E----------------GDHGREVG--RTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLG 590
Query: 727 -YAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTV 785
+ V + +T ++ + P + + TS+ L W+ PD NY
Sbjct: 591 AFTPVVRQRTLQS------------ISPKNFKVKMIMKTSVLLSWEFPD-------NYNS 631
Query: 786 RFSPWGLRNASLVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDG 832
+P+ ++ L LI LKP T Y F + + G + G
Sbjct: 632 P-TPYKIQYNGLTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGG 677
Score = 147 bits (370), Expect = 8e-35
Identities = 160/626 (25%), Positives = 259/626 (41%), Gaps = 64/626 (10%)
Query: 62 AAAGPPTRVTWSKDGDTL-------LEHDHLHLLPNGSLWLSQPLAPNGSDESVPEAVGV 114
A P RVTW+K G + +E D G++ QPL DE+V
Sbjct: 56 ATGDPKPRVTWNKKGKKVNSQRFETIEFDE----SAGAVLRIQPLR-TPRDENV------ 104
Query: 115 IEGNYSCLAHGPLGVLASQTAVVKL------ATLADFSLHPESQTVEENGTARFECHIEG 168
Y C+A +G + + L + + + P+ + VE TA C G
Sbjct: 105 ----YECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASG 160
Query: 169 LPAPIITWEKDQVTLPEEP-----RLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFS 223
P P ITW KD LP +P R+ L +G LQI +E+D G Y CVATNSA +S
Sbjct: 161 NPDPEITWFKD--FLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYS 218
Query: 224 QEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGK 283
A L V R P + ++ G +V + CVA P P+V W++
Sbjct: 219 SPANLYVRVRRVAPR-------FSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAED 271
Query: 284 PISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEA 343
D + +GR L + + + S Y C A + A A++ V + P P
Sbjct: 272 LTPEDDMPVGRNVLELTDVK--DSANYTCVAMS--SLGVIEAVAQITVKSLPKAPGTPMV 327
Query: 344 LSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYY 403
T +T+ + SG P P ++ +G +++ + + GL Y
Sbjct: 328 TENT--ATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEY 385
Query: 404 Q--CVAENSAGMACAAASLAVVVREGLP-SAPTRVTATPLSSSAVLVAWERPEMHSEQII 460
+ A NS G + S+ E P SAP V A LS++ ++V WE P + I
Sbjct: 386 EIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIR 445
Query: 461 GFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALV 520
G+ ++Y +Q +D+ V L + Y V+A++ +G S P V
Sbjct: 446 GYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQV 505
Query: 521 HTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKEDQIFSTEVR 580
T VP L + + + I ++W P P S ++KY++ + G +
Sbjct: 506 KTQQGVPGQPMNLRAEARSETSITLSWSP-PRQES---IIKYELLFREGDHGREVG-RTF 560
Query: 581 GNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQA 640
T ++ L+PN Y R++A + G GA TP + ++ +P KV+
Sbjct: 561 DPTTSYVVEDLKPNTEYAFRLAARSPQGLGA-------FTPVVRQRTLQSISPKNFKVKM 613
Query: 641 KME-SLVVSWQPPPHPTQISGYKLYW 665
M+ S+++SW+ P + + YK+ +
Sbjct: 614 IMKTSVLLSWEFPDNYNSPTPYKIQY 639
Score = 75.9 bits (185), Expect = 2e-13
Identities = 136/637 (21%), Positives = 243/637 (38%), Gaps = 94/637 (14%)
Query: 335 PAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQ---GGGGSLV 391
P + P+ A FVC+A+G+P+P + W G + ++ G L
Sbjct: 33 PRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLR 92
Query: 392 ITQIGL-QDAGYYQCVAENSAGMACAAASLAVVVREGLPSAPTRVTATPL--------SS 442
I + +D Y+CVA+NS G A L V+ + LPS + P ++
Sbjct: 93 IQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTA 152
Query: 443 SAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFY 502
+ + A P+ +I F N + + LQ+ E ++
Sbjct: 153 TMLCAASGNPD---PEITWFKDFLPVDPSASNGRIKQLRSG---ALQIESSEETDQGKYE 206
Query: 503 VVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKY 562
VA + G R S+PA ++ V AP+ S+ P +I ++ G + Y
Sbjct: 207 CVATNSAGV-RYSSPANLYVR--VRRVAPRFSIL-PMSHEIMPGGNVNITCVAVGSPMPY 262
Query: 563 KIEYGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPS 622
+++ G ED ++ L L ++ + Y ++ + A +Q P
Sbjct: 263 -VKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTC-VAMSSLGVIEAVAQITVKSLPK 320
Query: 623 MHNQSHVPFAPAELKVQAKMESLVVSWQPPPHPTQISGYKLYWREVGAEEEANGDRLPGG 682
P P + + S+ ++W +P +S Y + ++ +
Sbjct: 321 ------APGTP--MVTENTATSITITWDSG-NPDPVSYYVIEYKSKSQD----------- 360
Query: 683 RGDQAWDVGPVRLKKKVK--QYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPA 740
GP ++K+ + +Y + L P YE+ + A N G P+
Sbjct: 361 --------GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQG-----------PPS 401
Query: 741 PDMPIQRGPPLP---PAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRFSP-------- 789
+ + G P P +V A S+T++ ++W++P I Y V ++
Sbjct: 402 ESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGN 461
Query: 790 WGLRNA--SLVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRP 847
W N SL+T S ED + +T A S G DGP ++ T P
Sbjct: 462 WQKHNVDDSLLTTVGSLLED------ETYTVRVLAFTSVG---DGPLSDPIQVKTQQGVP 512
Query: 848 STPPSDLRLSPLTPSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFS 907
P +LR + +++ L W PP + + I++Y +L+ +H + T S
Sbjct: 513 GQP-MNLRAEARSETSITLSWSPPRQES--IIKYELLFREG----DHGREVGRTFDPTTS 565
Query: 908 AEVHGLESDTRYFFKMGARTEVGPGPFSRLQDVITLQ 944
V L+ +T Y F++ AR+ G G F+ + TLQ
Sbjct: 566 YVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQ 602
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 158 bits (400), Expect = 3e-38
Identities = 175/711 (24%), Positives = 289/711 (40%), Gaps = 87/711 (12%)
Query: 145 FSLHPESQTVEENGTARFECHIEGLPAPIITW-EKDQVTLPEEPRLIVLPNGVLQILDVQ 203
F P+ Q G A F C G P P +TW +K + + I +L +Q
Sbjct: 35 FIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQ 94
Query: 204 ----ESDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQ 259
D Y CVA NS + + A L+V L S I P+ V +
Sbjct: 95 PLRTPRDENVYECVAQNSVGE-ITVHAKLTVLREDQLPSGFPN---IDMGPQLKVVERTR 150
Query: 260 SVVMECVASADPTPFVSWVRQ----DGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRAN 315
+ M C AS +P P ++W + D + + L L I +++ G Y C A
Sbjct: 151 TATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECVAT 210
Query: 316 KPRTRDFATAA----AELRVL--AAPAITQAPEALSRTRASTARFVCRASGEPRPALRWL 369
+++ A ELR + AP + P + C A G P P ++W+
Sbjct: 211 NSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWM 270
Query: 370 HNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAVVVREGLP 429
L P + V G V+ ++D+ Y CVA +S G+ A A + V + LP
Sbjct: 271 QGAEDLTPEDDMPV----GRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV---KSLP 323
Query: 430 SAPTRVTATPLSSSAVLVAWE--RPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTE 487
AP T +++++ + W+ P+ S +I + K++ D YQ + TT
Sbjct: 324 KAPGTPMVTENTATSITITWDSGNPDPVSYYVIEY-----KSKSQDG-PYQIKEDITTTR 377
Query: 488 LQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQ-LSLSSPNPSDIRVA 546
+ L PN++YE +V A + +G S + T + P++AP+ + + + + V
Sbjct: 378 YSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQ 437
Query: 547 W-LPLPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGNETQLM--LNSLQPNKVYRVRISA 603
W P+ P NG + Y++ Y + E + + + + L+ + SL ++ Y VR+ A
Sbjct: 438 WEEPVEP---NGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLA 494
Query: 604 GTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQAKME-SLVVSWQPPPHPTQISGYK 662
T+ G G S + +T Q VP P L+ +A+ E S+ +SW PP + I Y+
Sbjct: 495 FTSVGDGPLSDPIQVKT-----QQGVPGQPMNLRAEARSETSITLSWSPPRQESIIK-YE 548
Query: 663 LYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNK 722
L +RE GD +VG R Y + L P Y +L A +
Sbjct: 549 LLFRE----------------GDHGREVG--RTFDPTTSYVVEDLKPNTEYAFRLAARSP 590
Query: 723 HEDG-YAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIV 781
G + V + +T ++ + P + + TS+ L W+ PD
Sbjct: 591 QGLGAFTPVVRQRTLQS------------ISPKNFKVKMIMKTSVLLSWEFPD------- 631
Query: 782 NYTVRFSPWGLRNASLVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDG 832
NY +P+ ++ L LI LKP T Y F + + G + G
Sbjct: 632 NYNSP-TPYKIQYNGLTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGG 681
Score = 149 bits (376), Expect = 2e-35
Identities = 161/626 (25%), Positives = 260/626 (41%), Gaps = 60/626 (9%)
Query: 62 AAAGPPTRVTWSKDGDTL-------LEHDHLHLLPNGSLWLSQPLAPNGSDESVPEAVGV 114
A P RVTW+K G + +E D G++ QPL DE+V
Sbjct: 56 ATGDPKPRVTWNKKGKKVNSQRFETIEFDE----SAGAVLRIQPLR-TPRDENV------ 104
Query: 115 IEGNYSCLAHGPLGVLASQTAVVKL------ATLADFSLHPESQTVEENGTARFECHIEG 168
Y C+A +G + + L + + + P+ + VE TA C G
Sbjct: 105 ----YECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASG 160
Query: 169 LPAPIITWEKDQVTLPEEP-----RLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFS 223
P P ITW KD LP +P R+ L +G LQI +E+D G Y CVATNSA +S
Sbjct: 161 NPDPEITWFKD--FLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYS 218
Query: 224 QEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGK 283
A L V L R P + ++ G +V + CVA P P+V W++
Sbjct: 219 SPANLYVR---ELREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAED 275
Query: 284 PISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEA 343
D + +GR L + + + S Y C A + A A++ V + P P
Sbjct: 276 LTPEDDMPVGRNVLELTDVK--DSANYTCVAMS--SLGVIEAVAQITVKSLPKAPGTPMV 331
Query: 344 LSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYY 403
T +T+ + SG P P ++ +G +++ + + GL Y
Sbjct: 332 TENT--ATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEY 389
Query: 404 Q--CVAENSAGMACAAASLAVVVREGLP-SAPTRVTATPLSSSAVLVAWERPEMHSEQII 460
+ A NS G + S+ E P SAP V A LS++ ++V WE P + I
Sbjct: 390 EIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIR 449
Query: 461 GFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALV 520
G+ ++Y +Q +D+ V L + Y V+A++ +G S P V
Sbjct: 450 GYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQV 509
Query: 521 HTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKEDQIFSTEVR 580
T VP L + + + I ++W P P S ++KY++ + G +
Sbjct: 510 KTQQGVPGQPMNLRAEARSETSITLSWSP-PRQES---IIKYELLFREGDHGREVG-RTF 564
Query: 581 GNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQA 640
T ++ L+PN Y R++A + G GA TP + ++ +P KV+
Sbjct: 565 DPTTSYVVEDLKPNTEYAFRLAARSPQGLGA-------FTPVVRQRTLQSISPKNFKVKM 617
Query: 641 KME-SLVVSWQPPPHPTQISGYKLYW 665
M+ S+++SW+ P + + YK+ +
Sbjct: 618 IMKTSVLLSWEFPDNYNSPTPYKIQY 643
Score = 79.0 bits (193), Expect = 3e-14
Identities = 138/639 (21%), Positives = 244/639 (38%), Gaps = 94/639 (14%)
Query: 335 PAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQ---GGGGSLV 391
P + P+ A FVC+A+G+P+P + W G + ++ G L
Sbjct: 33 PRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLR 92
Query: 392 ITQIGL-QDAGYYQCVAENSAGMACAAASLAVVVREGLPSAPTRVTATPL--------SS 442
I + +D Y+CVA+NS G A L V+ + LPS + P ++
Sbjct: 93 IQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTA 152
Query: 443 SAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFY 502
+ + A P+ +I F N + + LQ+ E ++
Sbjct: 153 TMLCAASGNPD---PEITWFKDFLPVDPSASNGRIKQLRSG---ALQIESSEETDQGKYE 206
Query: 503 VVAYSQLGASRTSTPA--LVHTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVV 560
VA + G R S+PA V L +V AP+ S+ P +I ++ G +
Sbjct: 207 CVATNSAGV-RYSSPANLYVRELREVRRVAPRFSIL-PMSHEIMPGGNVNITCVAVGSPM 264
Query: 561 KYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRT 620
Y +++ G ED ++ L L ++ + Y ++ + A +Q
Sbjct: 265 PY-VKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTC-VAMSSLGVIEAVAQITVKSL 322
Query: 621 PSMHNQSHVPFAPAELKVQAKMESLVVSWQPPPHPTQISGYKLYWREVGAEEEANGDRLP 680
P P P + + S+ ++W +P +S Y + ++ +
Sbjct: 323 PK------APGTP--MVTENTATSITITWDSG-NPDPVSYYVIEYKSKSQD--------- 364
Query: 681 GGRGDQAWDVGPVRLKKKVK--QYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKA 738
GP ++K+ + +Y + L P YE+ + A N G
Sbjct: 365 ----------GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQG-----------P 403
Query: 739 PAPDMPIQRGPPLP---PAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRFSP------ 789
P+ + + G P P +V A S+T++ ++W++P I Y V ++
Sbjct: 404 PSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPV 463
Query: 790 --WGLRNA--SLVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPD 845
W N SL+T S ED + +T A S G DGP ++ T
Sbjct: 464 GNWQKHNVDDSLLTTVGSLLED------ETYTVRVLAFTSVG---DGPLSDPIQVKTQQG 514
Query: 846 RPSTPPSDLRLSPLTPSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNI 905
P P +LR + +++ L W PP + + I++Y +L+ +H + T
Sbjct: 515 VPGQP-MNLRAEARSETSITLSWSPPRQES--IIKYELLFREG----DHGREVGRTFDPT 567
Query: 906 FSAEVHGLESDTRYFFKMGARTEVGPGPFSRLQDVITLQ 944
S V L+ +T Y F++ AR+ G G F+ + TLQ
Sbjct: 568 TSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQ 606
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 157 bits (397), Expect = 6e-38
Identities = 204/787 (25%), Positives = 312/787 (39%), Gaps = 117/787 (14%)
Query: 42 PLQVILGPEQAAVLNCSLGAAAAGPPTRVTWSKDGD---TLLEHDHLH--LLPNGSLWLS 96
P +++ + A L C A P + W K+G T+ E H LLP+G+L+
Sbjct: 70 PPDLLVSRGEPATLPCR---AEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFF- 125
Query: 97 QPLAPNGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLAD-FSLHPESQTVE 155
P +G + P+ EG Y+C+A LG AS+ A +++A L D F P + V
Sbjct: 126 -PRIVHGR-RARPD-----EGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVA 178
Query: 156 ENGTARFEC-HIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCVA 214
A EC G P P ++W KD L EE I + G L + +SDAG Y CVA
Sbjct: 179 VGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVA 238
Query: 215 TNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPF 274
+N A + S A + V R S + P N V++ V C DP P
Sbjct: 239 SNMAGERESAAAEVMVLERPS----------FLRRPVNQVVLADAPVTFLCEVKGDPPPR 288
Query: 275 VSWVRQDGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLAA 334
+ W ++DG+ + + +L I + G Y C A R A A+ L V
Sbjct: 289 LRWRKEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGR--AEASGSLSVHVP 346
Query: 335 PAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGA--------PLRPNGRVKVQGG 386
P + P+ + F C G P PA+ W G+ L+P GR V
Sbjct: 347 PQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSV-SP 405
Query: 387 GGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAV--VVREGLP----SAPTRVTATPL 440
G L IT + DAGYY C A + AG A A L + +GLP P T L
Sbjct: 406 RGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLV-L 464
Query: 441 SSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYE 500
SS L R + + + + Q +G D+++++ N V+++ D
Sbjct: 465 GSSVWLPC--RVTGNPQPSVRWKKDGQWLQG-DDLQFKTMANGTLYIANVQEM----DMG 517
Query: 501 FY-VVAYSQLGASRTS-----------TPALVHTLDDVPSAAPQLSLSSPNPSDIRVAWL 548
FY VA S G + S +P P A Q ++ + I + W
Sbjct: 518 FYSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWK 577
Query: 549 PLPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGNETQL-MLNSLQPNKVYRVRISAGTAA 607
P P + V Y IE + T G + + ++ LQPN +Y + A A
Sbjct: 578 PNPQ--TGAAVTSYVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAW 635
Query: 608 GFGAPSQWMHHRTPSMHNQSHVPFAPAE---------LKVQAKME--------SLVVSWQ 650
G PS + + Q P P E +V +++ +L VSW
Sbjct: 636 GLSEPSP----VSEPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWT 691
Query: 651 PPPHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPG 710
+ G+++ WR G E GG +W + ++ + + L L PG
Sbjct: 692 VDGPVQLVQGFRVSWRVAGPE---------GG----SWTMLDLQSPSQ-QSTVLRGLPPG 737
Query: 711 RLYEVKLVAFNKHEDGYAA----VWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSI 766
++K+ A + ++G A V + E+AP+ GPP A V + ++SI
Sbjct: 738 TQIQIKVQA--QGQEGLGAESLSVTRSIPEEAPS-------GPPQGVA-VALGGDGNSSI 787
Query: 767 WLRWKKP 773
+ W+ P
Sbjct: 788 TVSWEPP 794
Score = 127 bits (319), Expect = 7e-29
Identities = 153/617 (24%), Positives = 237/617 (38%), Gaps = 95/617 (15%)
Query: 66 PPTRVTWSKDGDTLLEHDHLHLLPNGSLWLSQPLAPNGSDESVPEAVGVIEGNYSCLAHG 125
PP R+ W K+ D L + + SLW+ A + EG Y+C+A
Sbjct: 285 PPPRLRWRKE-DGELPTGRYEIRSDHSLWIGHVSAED-------------EGTYTCVAEN 330
Query: 126 PLGVLASQTAVVKLATLADFSLHPESQTVEENGTARFECHIEGLPAPIITWEKD------ 179
+G A + + + P+ Q + F+C +G P P I W+K+
Sbjct: 331 SVG-RAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLL 389
Query: 180 --QVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEALLSVAHRGSLA 237
+L R V P G L I VQ DAG Y C A + A ++ ALL + A
Sbjct: 390 FPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAK-ALLEIKG----A 444
Query: 238 STRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTDVI---VLGR 294
S G VI+ P N T+V G SV + C + +P P V W ++DG+ + D + +
Sbjct: 445 SLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRW-KKDGQWLQGDDLQFKTMAN 503
Query: 295 TNLLIANAQPWHSGVYVCRAN--------------------------KPRTRDFATAAAE 328
L IAN Q G Y C A +P + A +
Sbjct: 504 GTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPV 563
Query: 329 LRVLAAPAITQAPEALSRTRASTARFVCRASGEPRPALRW----------LHNGAPLRPN 378
+ + +IT + +T A+ +V A P W H + L+PN
Sbjct: 564 VTEITKNSITLTWKPNPQTGAAVTSYVIEAFS-PAAGNTWRTVADGVQLETHTVSGLQPN 622
Query: 379 G----RVKVQGGGG----SLVITQIGLQDAGYYQCVAENSAGMACAAASLAVVVREGLPS 430
V+ G G S V + QD+ + V + G A +AV ++E +
Sbjct: 623 TIYLFLVRAVGAWGLSEPSPVSEPVRTQDSSPSRPVEDPWRGQQ-GLAEVAVRLQEPIVL 681
Query: 431 APTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQV 490
P + + V + + GF + ++ A + + + + V
Sbjct: 682 GPRTLQVSWTVDGPV-----------QLVQGFRVSWRVAGPEGGSWTMLDLQSPSQQSTV 730
Query: 491 -RDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQ---LSLSSPNPSDIRVA 546
R L P T + V A Q G S ++ PS PQ ++L S I V+
Sbjct: 731 LRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPSGPPQGVAVALGGDGNSSITVS 790
Query: 547 WLPLPPSLSNGQVVKYKIEYGLGKEDQI-FSTEVRGNETQLMLNSLQPNKVYRVRISAGT 605
W P PS NG + +Y+I + LG E + + G ML L P +YR ++A T
Sbjct: 791 WEPPLPSQQNGVITEYQI-WCLGNESRFHLNRSAAGWARSAMLRGLVPGLLYRTLVAAAT 849
Query: 606 AAGFGAPSQWMHHRTPS 622
+AG G PS + + PS
Sbjct: 850 SAGVGVPSAPVLVQLPS 866
Score = 54.3 bits (129), Expect = 7e-07
Identities = 58/204 (28%), Positives = 85/204 (41%), Gaps = 39/204 (19%)
Query: 246 IVAAPENTTVVSGQSVVMECVASADPTPFVSW---------VRQDGK---------PIST 287
IV P + V G+ + C A P P + W VR+D + +
Sbjct: 66 IVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFF 125
Query: 288 DVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAI-----TQAPE 342
IV GR A+P GVY C A R++ AAA A+ Q+P
Sbjct: 126 PRIVHGR------RARP-DEGVYTCVA-----RNYLGAAASRNASLEVAVLRDDFRQSPG 173
Query: 343 ALSRTRASTARFVC-RASGEPRPALRWLHNGAPLR-PNGRVKVQGGGGSLVITQIGLQDA 400
+ A C G P P++ W +GA L+ GR+ ++ GG L+++ DA
Sbjct: 174 NVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIR--GGKLMMSHTLKSDA 231
Query: 401 GYYQCVAENSAGMACAAASLAVVV 424
G Y CVA N AG +AA+ +V+
Sbjct: 232 GMYVCVASNMAGERESAAAEVMVL 255
Score = 50.1 bits (118), Expect = 1e-05
Identities = 40/114 (35%), Positives = 53/114 (46%), Gaps = 11/114 (9%)
Query: 333 AAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNG---APLRPNGRV-KVQGGGG 388
A P I + P L +R A CRA G PRP + W NG A +R + R ++ G
Sbjct: 62 AMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSG 121
Query: 389 SLVITQI-----GLQDAGYYQCVAENSAGMACAA-ASLAV-VVREGLPSAPTRV 435
+L +I D G Y CVA N G A + ASL V V+R+ +P V
Sbjct: 122 ALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNV 175
Score = 35.4 bits (80), Expect = 0.34
Identities = 61/235 (25%), Positives = 92/235 (39%), Gaps = 42/235 (17%)
Query: 729 AVWKG----KTEKAPAPDMPIQ-RGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVNY 783
A W G + + +PD P + PP P+ + SI L WK T + +Y
Sbjct: 530 ATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSY 589
Query: 784 TVR-FSPWGLRNASLVTYYTSSG----EDILIGGLKPFTKYEF---AVQSHGVDMDGPFG 835
+ FSP A+ T+ T + E + GL+P T Y F AV + G+ P
Sbjct: 590 VIEAFSP-----AAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVS 644
Query: 836 SVVE-RSTLPDRPSTPP---------SDLRLSP---LTPSTVRLHWC---PPTEPNGEIV 879
V + + P RP P +RL L P T+++ W P G V
Sbjct: 645 EPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRV 704
Query: 880 EYLILYSSNHTQPE-HQWTLLTTQG-NIFSAEVHGLESDTRYFFKMGARTEVGPG 932
+ + PE WT+L Q + S + GL T+ K+ A+ + G G
Sbjct: 705 SWRV------AGPEGGSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLG 753
Score = 33.1 bits (74), Expect = 1.7
Identities = 50/185 (27%), Positives = 69/185 (37%), Gaps = 33/185 (17%)
Query: 982 PHRESLPGLSSTATPGNPALYSRARLGPPSPPAAHELESLVHPHPQDWSPPPSDVEDRAE 1041
P R L SS+ G SR P+P + + + P P D PP+D+ +
Sbjct: 1118 PERSHLTEPSSSG--GCLVTPSRRETPSPTPSYGQQSTATLTPSPPDPPQPPTDMPHLHQ 1175
Query: 1042 VHSLMGGGVSEGRSHSKRK--ISWAQPSGLSWAGSWAGCELPQAGPRPALTRALLPPAGT 1099
+ + G S S S+ I A+P+GL AG A P P PA + A P T
Sbjct: 1176 MPRRVPLGPSSPLSVSQPMLGIREARPAGLG-AGPAAS---PHLSPSPAPSTASSAPGRT 1231
Query: 1100 GQTLLLQALVYDAIKGNGRKKSP---PACRNQVEAEVIVHSDFSASNGNPDLHLQDLEPE 1156
Q GNG P P R + + + + + N DL P
Sbjct: 1232 WQ-------------GNGEMTPPLQGPRARFRKKPKAL---PYRRENSPGDL------PP 1269
Query: 1157 DPLPP 1161
PLPP
Sbjct: 1270 PPLPP 1274
Score = 31.6 bits (70), Expect = 5.0
Identities = 30/124 (24%), Positives = 50/124 (40%), Gaps = 8/124 (6%)
Query: 822 AVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRLSPLTPSTVRLHWCPPTEPNGEIVEY 881
A S + M +G + T P P PS ++ +T +++ L W P + + Y
Sbjct: 530 ATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSY 589
Query: 882 LILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESDTRYFF---KMGARTEVGPGPFS--- 935
+I + + W + + + V GL+ +T Y F +GA P P S
Sbjct: 590 VI--EAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPV 647
Query: 936 RLQD 939
R QD
Sbjct: 648 RTQD 651
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,121,986
Number of Sequences: 37866
Number of extensions: 3269252
Number of successful extensions: 20231
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 265
Number of HSP's successfully gapped in prelim test: 321
Number of HSP's that attempted gapping in prelim test: 11181
Number of HSP's gapped (non-prelim): 4266
length of query: 1250
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1136
effective length of database: 13,930,794
effective search space: 15825381984
effective search space used: 15825381984
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.