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Search of human proteins with 195539372
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|195539372 ADAM metallopeptidase with thrombospondin type 1
motif, 5 preproprotein [Homo sapiens]
(930 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo... 1949 0.0
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot... 728 0.0
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 691 0.0
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 652 0.0
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 580 e-165
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 556 e-158
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 551 e-156
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 452 e-127
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 399 e-111
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 397 e-110
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 396 e-110
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 392 e-109
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 377 e-104
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 372 e-102
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 370 e-102
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 364 e-100
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 363 e-100
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 346 7e-95
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 340 5e-93
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 266 7e-71
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 266 7e-71
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 241 3e-63
gi|11038659 ADAM metallopeptidase with thrombospondin type 1 mot... 166 7e-41
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 162 1e-39
gi|145309328 papilin [Homo sapiens] 162 2e-39
gi|226442878 ADAMTS-like 5 [Homo sapiens] 159 1e-38
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 159 1e-38
gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens] 159 1e-38
gi|223718260 ADAMTS-like 2 precursor [Homo sapiens] 156 7e-38
gi|41281450 ADAMTS-like 2 precursor [Homo sapiens] 156 7e-38
>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
motif, 5 preproprotein [Homo sapiens]
Length = 930
Score = 1949 bits (5050), Expect = 0.0
Identities = 930/930 (100%), Positives = 930/930 (100%)
Query: 1 MLLGWASLLLCAFRLPLAAVGPAATPAQDKAGQPPTAAAAAQPRRRQGEEVQERAEPPGH 60
MLLGWASLLLCAFRLPLAAVGPAATPAQDKAGQPPTAAAAAQPRRRQGEEVQERAEPPGH
Sbjct: 1 MLLGWASLLLCAFRLPLAAVGPAATPAQDKAGQPPTAAAAAQPRRRQGEEVQERAEPPGH 60
Query: 61 PHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDGSVGIAGFVPAGGGT 120
PHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDGSVGIAGFVPAGGGT
Sbjct: 61 PHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDGSVGIAGFVPAGGGT 120
Query: 121 SAPWRHRSHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGR 180
SAPWRHRSHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGR
Sbjct: 121 SAPWRHRSHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGR 180
Query: 181 VYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLD 240
VYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLD
Sbjct: 181 VYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLD 240
Query: 241 QSALSPAGGSGPQTWWRRRRRSISRARQVELLLVADASMARLYGRGLQHYLLTLASIANR 300
QSALSPAGGSGPQTWWRRRRRSISRARQVELLLVADASMARLYGRGLQHYLLTLASIANR
Sbjct: 241 QSALSPAGGSGPQTWWRRRRRSISRARQVELLLVADASMARLYGRGLQHYLLTLASIANR 300
Query: 301 LYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYD 360
LYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYD
Sbjct: 301 LYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYD 360
Query: 361 AAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSH 420
AAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSH
Sbjct: 361 AAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSH 420
Query: 421 DDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQI 480
DDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQI
Sbjct: 421 DDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQI 480
Query: 481 LGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGT 540
LGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGT
Sbjct: 481 LGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGT 540
Query: 541 PCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPR 600
PCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPR
Sbjct: 541 PCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPR 600
Query: 601 NNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVL 660
NNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVL
Sbjct: 601 NNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVL 660
Query: 661 PADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDK 720
PADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDK
Sbjct: 661 PADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDK 720
Query: 721 CGVCGGDNSSCTKIVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKK 780
CGVCGGDNSSCTKIVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKK
Sbjct: 721 CGVCGGDNSSCTKIVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKK 780
Query: 781 NGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPT 840
NGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPT
Sbjct: 781 NGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPT 840
Query: 841 KPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTV 900
KPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTV
Sbjct: 841 KPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTV 900
Query: 901 QCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
QCQDGNRKLAKGCPLSQRPSAFKQCLLKKC
Sbjct: 901 QCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
1 preproprotein [Homo sapiens]
Length = 967
Score = 728 bits (1878), Expect = 0.0
Identities = 376/863 (43%), Positives = 500/863 (57%), Gaps = 38/863 (4%)
Query: 83 GGGKVGYLVYAGGRRFLLDLERDGSVGIAGFV------PAGGGTSAPWRHRSHCFYRGTV 136
G G ++A ++ L+L D S GF +G T P +HCFY GTV
Sbjct: 70 GHGTTRLRLHAFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDLAHCFYSGTV 129
Query: 137 DGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGRVY-GDGSARILHVY-- 193
+G P S A LC G+ G F + Y ++PL P A E G+ L +
Sbjct: 130 NGDPSSAAALSLCEGVRGAFYLLGEAYFIQPL---PAASERLATAAPGEKPPAPLQFHLL 186
Query: 194 --TREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAAL--ASQLLDQSALSPAGG 249
R+G +C P A G +Q Q G
Sbjct: 187 RRNRQG------DVGGTCGVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVG 240
Query: 250 SGPQTWWRRRRRSISRARQVELLLVADASMARLYGRGLQHYLLTLASIANRLYSHASIEN 309
T R++R +S R VE +LVAD SMA +G GL+HYLLTL S+A RLY H SI N
Sbjct: 241 QPTGTGSIRKKRFVSSHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRN 300
Query: 310 HIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTRED 369
+ L VVK++V+ D+ K EV+ NAA TL+NFC WQ QHN D EHYD AILFTR+D
Sbjct: 301 SVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQD 360
Query: 370 LCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEET 429
LCG +CDTLGMADVGT+C P RSC+VIEDDGL AAFT AHE+GH+ + HDD+K C
Sbjct: 361 LCGSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASL 420
Query: 430 FGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQILGPEELPGQ 489
G +D +M+S+L+++D S+PWS C++ IT FLD+GHG CL+D P+ I P +LPG
Sbjct: 421 NGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLPGT 480
Query: 490 TYDATQQCNLTFGPEYSVCP-GMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRIC 548
+YDA +QC TFG + CP C+ LWC G +VC TK P +GT CG+G+ C
Sbjct: 481 SYDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWC 540
Query: 549 LQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTG 608
+ GKCV+KT +K++ T HG+WG WG WG CSR+CGGGVQ+ R C+NP P+N G+YC G
Sbjct: 541 INGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEG 600
Query: 609 KRAIYRSCSLMPCPP-NGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKL 667
KR YRSC+L CP NGK+FR EQCEA N + + G VEW+PKYAGV P D CKL
Sbjct: 601 KRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKL 660
Query: 668 TCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGD 727
C+AKG GY+ V PKV DGT C S SVCV+G+CV+ GCD II SK ++DKCGVCGG+
Sbjct: 661 ICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGN 720
Query: 728 NSSCTKIVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLIN 787
S+C KI G+ GY D++ IP GAT+I+V+Q + ++LA+K +G Y++N
Sbjct: 721 GSTCKKISGSVTSAKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILN 780
Query: 788 GKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKPLDVRY 847
G Y +ST E I G V+ YSG S + + +S KE L +Q+L ++Y
Sbjct: 781 GDYTLSTLEQDIMYKGVVLRYSGSSAALERIR--SFSPLKEPLTIQVLTVGNALRPKIKY 838
Query: 848 SFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNR 907
++FV KK N++ + + WV W CS++C+ GW R V+C+D N
Sbjct: 839 TYFV-KKKKESFNAIPTFSA-----------WVIEEWGECSKSCELGWQRRLVECRDING 886
Query: 908 KLAKGCPLSQRPSAFKQCLLKKC 930
+ A C +P++ + C C
Sbjct: 887 QPASECAKEVKPASTRPCADHPC 909
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin
type) with thrombospondin type 1 motif, 15 preproprotein
[Homo sapiens]
Length = 950
Score = 691 bits (1784), Expect = 0.0
Identities = 361/814 (44%), Positives = 471/814 (57%), Gaps = 42/814 (5%)
Query: 130 CFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGRVYGDGSARI 189
CFY G V+ P S A LCGGL G F + A Y + PL P A + G+
Sbjct: 101 CFYSGDVNAEPDSFAAVSLCGGLRGAFGYRGAEYVISPL---PNASAPAAQRNSQGA--- 154
Query: 190 LHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLDQSALSPAGG 249
H+ R G P+ P + + NP+ AL ++ G
Sbjct: 155 -HLLQRRGVP----------GGPSGDPTSRCGVASGWNPAILRALDPYKPRRAGF---GE 200
Query: 250 SGPQTWWRRRRRSISRARQVELLLVADASMARLYGRGLQHYLLTLASIANRLYSHASIEN 309
S + R +R +S R VE L+VAD SM + +G L+HYLLTL + A RLY H SI N
Sbjct: 201 SRSRRRSGRAKRFVSIPRYVETLVVADESMVKFHGADLEHYLLTLLATAARLYRHPSILN 260
Query: 310 HIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTRED 369
I + VVKV++L D+D +V+ NAA TL+NFC WQ + N++ D H E++D AILFTR+D
Sbjct: 261 PINIVVVKVLLLRDRDSGPKVTGNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQD 320
Query: 370 LCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEET 429
LCG +CDTLGMADVGT+C P+RSC+VIEDDGL +AFT AHE+GH+ + HD+ K CEE
Sbjct: 321 LCGATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEV 380
Query: 430 FGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQILGPEELPGQ 489
FG +MS L ID + PWS C++A IT+FLD GHG+CLLD P K I PE+LPG
Sbjct: 381 FGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKPISLPEDLPGA 440
Query: 490 TYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICL 549
+Y +QQC L FG CP M C +LWC +GQMVC T+ P +GT CG+G++CL
Sbjct: 441 SYTLSQQCELAFGVGSKPCPYMQYCTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKLCL 500
Query: 550 QGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGK 609
+G CV++ + G+W W +G CSR+CGGGVQ A R C NP P N G+YC G
Sbjct: 501 KGACVERHNLNKHRVD--GSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGV 558
Query: 610 RAIYRSCSLMPCP--PNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKL 667
R YRSC+L PCP +GKSFR EQCEA NGY + V WVPKY+GV P D CKL
Sbjct: 559 RVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKL 618
Query: 668 TCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGD 727
CRA GTGY+ V +PKV DGT C S SVCV+GKC++ GCDG +GSK ++DKCGVCGGD
Sbjct: 619 ICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGD 678
Query: 728 NSSCTKIVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLIN 787
N SC K+ G F K GY VV IP GA+ I +RQ K YLALK G+YL+N
Sbjct: 679 NKSCKKVTGLFTKPMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLN 738
Query: 788 GKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKPLDVRY 847
G +++S E + + G+++ YSG + L E L V++L+ P VRY
Sbjct: 739 GHFVVSAVERDLVVKGSLLRYSGTGTAVESLQAS--RPILEPLTVEVLSVGKMTPPRVRY 796
Query: 848 SFFVPKK---------STPKVNSVTSHGSNKVGSHTSQP------QWVTGPWLACSRTCD 892
SF++PK+ P+ SV + + + QP +WV G W CS +C
Sbjct: 797 SFYLPKEPREDKSSHPKDPRGPSVLHNSVLSLSNQVEQPDDRPPARWVAGSWGPCSASCG 856
Query: 893 TGWHTRTVQCQ-DGNRKLAKGCPLSQRPSAFKQC 925
+G R V C+ ++ C + RP + C
Sbjct: 857 SGLQKRAVDCRGSAGQRTVPACDAAHRPVETQAC 890
Score = 42.0 bits (97), Expect = 0.003
Identities = 19/56 (33%), Positives = 30/56 (53%), Gaps = 2/56 (3%)
Query: 877 PQWVTGPWLACSRTCDTGWHTRTVQC-QDGNRKLAKG-CPLSQRPSAFKQCLLKKC 930
P W W CS++C G+ R+++C G R LA+ C L ++P C+L+ C
Sbjct: 895 PTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 652 bits (1682), Expect = 0.0
Identities = 359/873 (41%), Positives = 482/873 (55%), Gaps = 51/873 (5%)
Query: 79 QLYSGGGKVGYLVYAGGRRFLLDLERDGSVGIAGF----VPAGGGTSAPWRHRSHCFYRG 134
+L G++ + A G+ F+L L D S F + G + R CF+ G
Sbjct: 45 RLPGSAGELALHLSAFGKGFVLRLAPDDSFLAPEFKIERLGGSGRATGGERGLRGCFFSG 104
Query: 135 TVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPL-LRGPWAEEEKGRVYGDGSARIL--- 190
TV+G P SLA LC GL G F + +T++P G A+ + + +G AR L
Sbjct: 105 TVNGEPESLAAVSLCRGLSGSFLLDGEEFTIQPQGAGGSLAQPHRLQRWGPAGARPLPRG 164
Query: 191 ---HVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLDQSALSPA 247
V T EG E R + + E A S P P
Sbjct: 165 PEWEVETGEGQRQE----RGDHQEDSEEESQEEEAEGASEPP---------------PPL 205
Query: 248 GGSGPQTWWRRRRRSISRARQVELLLVADASMARLYGRGLQHYLLTLASIANRLYSHASI 307
G + R +R +S AR VE LLVADASMA YG LQ+++LTL S+A R+Y H SI
Sbjct: 206 GATS------RTKRFVSEARFVETLLVADASMAAFYGADLQNHILTLMSVAARIYKHPSI 259
Query: 308 ENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTR 367
+N I L VVKV+++ D+ EVS N TL+NFC WQ + NQ D H EHYD AIL TR
Sbjct: 260 KNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLTR 319
Query: 368 EDLCGHHS-CDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFC 426
++ CG CDTLG+AD+GTIC P +SC+VIED+GL AA T+AHE+GH+L + HDDSK C
Sbjct: 320 QNFCGQEGLCDTLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSKPC 379
Query: 427 EETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQILGPEEL 486
FG +M+ + ++ + PWS C++ +TE LD GHG+CLLD P + P L
Sbjct: 380 TRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDAPAAALPLPTGL 439
Query: 487 PGQT--YDATQQCNLTFGPEYSVCPG---MDVCARLWCAVVRQGQMVCLTKK--LPAVEG 539
PG+ Y QQC FGP++ CP DVCA+LWC + +C TK LP +G
Sbjct: 440 PGRMALYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHT-DGAEPLCHTKNGSLPWADG 498
Query: 540 TPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAP 599
TPCG G +C +G C+ + + + + G W WG WG+CSR+CGGGVQF++R C +P P
Sbjct: 499 TPCGPGHLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEP 558
Query: 600 RNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQ-SDAKGVKTFVEWVPKYAG 658
+N GRYC G+RA Y+SC CPP+GKSFR +QCE N Y +D G ++WVPKYAG
Sbjct: 559 QNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDG--NLLQWVPKYAG 616
Query: 659 VLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQY 718
V P D CKL CRA+G + VF KV DGT C + ++CVRG+CV+ GCD ++ S +
Sbjct: 617 VSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPETLAICVRGQCVKAGCDHVVDSPRKL 676
Query: 719 DKCGVCGGDNSSCTKIVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALK 778
DKCGVCGG +SC K+ G+ + GY D+V IP GAT+I V+Q YLALK
Sbjct: 677 DKCGVCGGKGNSCRKVSGSLTPTNYGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALK 736
Query: 779 KKNGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILAT- 837
+G+YL+NG IS E I + GT++ YSG + L + E L VQ+L
Sbjct: 737 TADGQYLLNGNLAISAIEQDILVKGTILKYSGSIATLERL--QSFRPLPEPLTVQLLTVP 794
Query: 838 DPTKPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHT 897
P V+Y+FFVP + S + + QWV G W CS TC GW
Sbjct: 795 GEVFPPKVKYTFFVPNDVDFSMQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQR 854
Query: 898 RTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
RTV+C+D + + + C + +P K C + C
Sbjct: 855 RTVECRDPSGQASATCNKALKPEDAKPCESQLC 887
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 580 bits (1495), Expect = e-165
Identities = 318/776 (40%), Positives = 435/776 (56%), Gaps = 61/776 (7%)
Query: 93 AGGRRFLLDLERDGSVGIAGFVPAGGGTSAPWRHRSH--CFYRGTVDGSPRSLAVFDLCG 150
A G LL+LE+D V + G G + + + GT++G P S+A G
Sbjct: 87 AFGETLLLELEQDSGVQVEGLTVQYLGQAPELLGGAEPGTYLTGTINGDPESVASLHWDG 146
Query: 151 G-LDGFFAVKHARYTLKPLLRGPWAEEEKGRVYGDGSARILHVYTREGFSFEALPPRASC 209
G L G + A L+PL G
Sbjct: 147 GALLGVLQYRGAELHLQPLEGG-------------------------------------- 168
Query: 210 ETPASTPEAHEHAPAHSNP-SGRAALASQLLDQSALSPAGGSGPQTWWRRRRRSISRARQ 268
TP S H +P SG+ + + +P G P+ RR +R S +R
Sbjct: 169 -TPNSAGGPGAHILRRKSPASGQGPMCN------VKAPLGSPSPRP--RRAKRFASLSRF 219
Query: 269 VELLLVADASMARLYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSL 328
VE L+VAD MA +G GL+ YLLT+ + A + + H SI N + L V ++V+LG ++
Sbjct: 220 VETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGP 279
Query: 329 EVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMADVGTIC 388
+V +AA TL++FC WQ N D +H+D AILFTR+DLCG +CDTLGMADVGT+C
Sbjct: 280 QVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVC 339
Query: 389 SPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKR-LMSSILTSID 447
P RSCA++EDDGL +AFT AHE+GH+ + HD+SK C G R +M+ ++ +D
Sbjct: 340 DPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVD 399
Query: 448 ASKPWSKCTSATITEFLDDGHGNCLLDLPRKQILGPEELPGQTYDATQQCNLTFGPEYSV 507
+PWS C++ IT+FLD+G+G+CLLD P + P PG+ YDA +QC LTFGP+
Sbjct: 400 PEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRH 459
Query: 508 CPGM-DVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSS 566
CP + CA LWC+ G +C TK P +GTPCG + C+ G+C+ + + ++
Sbjct: 460 CPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQ 519
Query: 567 HGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPP-NG 625
G WG WG WG CSR+CGGGVQF+ R C P PRN G+YC G+R +RSC+ CP +
Sbjct: 520 AGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSA 579
Query: 626 KSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVT 685
+FR EQC A N K ++WVP+Y GV P D CKLTC+A+ GYY V P+V
Sbjct: 580 LTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVV 639
Query: 686 DGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKKSKGY 745
DGT C S+SVCV+G+C+ GCD IIGSK ++DKC VCGGD S C+K G+F K GY
Sbjct: 640 DGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYGY 699
Query: 746 TDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDINGTV 805
+VV IP GATHI VRQ + + YLALK +G Y +NG+Y + S T + + G V
Sbjct: 700 NNVVTIPAGATHILVRQ--QGNPGHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAV 757
Query: 806 -MNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVPK--KSTPK 858
+ YSG + + L G G A + L +Q+L + +RYSFFVP+ STP+
Sbjct: 758 SLRYSGATAASETLSGHGPLA--QPLTLQVLVAGNPQDTRLRYSFFVPRPTPSTPR 811
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 556 bits (1432), Expect = e-158
Identities = 312/869 (35%), Positives = 458/869 (52%), Gaps = 56/869 (6%)
Query: 49 EEVQERAEPPGHPHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDGSV 108
E V E E H ++++RS ++ + + Y A G+ F L+L D S
Sbjct: 46 ERVNEFGEVFPQSHHFSRQKRSSEALEPMPF------RTHYRFTAYGQLFQLNLTADASF 99
Query: 109 GIAGFVPAGGGTS--APWRHRS------HCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKH 160
AG+ GT W + HCFYRG V+ AV LCGGL G F ++
Sbjct: 100 LAAGYTEVHLGTPERGAWESDAGPSDLRHCFYRGQVNSQEDYKAVVSLCGGLTGTFKGQN 159
Query: 161 ARYTLKPLLRGPWAEEEKGRVYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHE 220
Y L+P+++ G Y DG + H+ R+ + L C S +
Sbjct: 160 GEYFLEPIMKAD------GNEYEDGHNKP-HLIYRQDLNNSFLQTLKYCSVSESQIK-ET 211
Query: 221 HAPAHSNPSGRAALASQLLDQSALSPAGGSGPQTWWRR---RRRSISRARQVELLLVADA 277
P H+ + L ++ + L + P RR ++R IS R +E+++ ADA
Sbjct: 212 SLPFHTYSNMNEDL--NVMKERVLGHTSKNVPLKDERRHSRKKRLISYPRYIEIMVTADA 269
Query: 278 SMARLYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATT 337
+ +G LQ+Y+LTL SI +Y SI N I + VVK+V++ +++ ++ + ATT
Sbjct: 270 KVVSAHGSNLQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHREEEGPVINFDGATT 329
Query: 338 LKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGH-HSCDTLGMADVGTICSPERSCAV 396
LKNFC WQ N L D H H+D A+L TRED+C C+ LG++ +GTIC P +SC +
Sbjct: 330 LKNFCSWQQTQNDLDDVHPSHHDTAVLITREDICSSKEKCNMLGLSYLGTICDPLQSCFI 389
Query: 397 IEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCT 456
E+ GL +AFT+AHE+GH LG+ HDD+ C+E +M+ L+ + WS C+
Sbjct: 390 NEEKGLISAFTIAHELGHTLGVQHDDNPRCKEM--KVTKYHVMAPALSFHMSPWSWSNCS 447
Query: 457 SATITEFLDDGHGNCLLDLPRKQILG-PEELPGQTYDATQQCNLTFGPEYSVCPGMDVCA 515
+TEFLD G+G CLLD P ++I P ELPG YD +QC L FGP +CP +++C
Sbjct: 448 RKYVTEFLDTGYGECLLDKPDEEIYNLPSELPGSRYDGNKQCELAFGPGSQMCPHINICM 507
Query: 516 RLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGS 575
LWC + C T+ +P +GT CG G C G CV+K + + +G WG W
Sbjct: 508 HLWCTSTEKLHKGCFTQHVPPADGTDCGPGMHCRHGLCVNKETE---TRPVNGEWGPWEP 564
Query: 576 WGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEA 635
+ CSR+CGGG++ A R CN P PRN G YC G+R +RSC+ CP + FR +QC
Sbjct: 565 YSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQDFREKQCSD 624
Query: 636 KNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSN 695
NG D G+ + V W+P+Y+G+ D CKL C+ GT Y+ + V DGT C ++
Sbjct: 625 FNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVEDGTPCGTETH 684
Query: 696 SVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKKSKGYTDVVRIPEGA 755
+CV+G+C+ GCD ++ S + DKCGVCGGDNSSC I G FN GY VV+IP GA
Sbjct: 685 DICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNSSHYGYNVVVKIPAGA 744
Query: 756 THIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDING--TVMNYSGWSH 813
T++ +RQ+ Q +YLAL G +L NG +++STS+ I++ G TV+ YSG ++
Sbjct: 745 TNVDIRQYSYSGQPD-DSYLALSDAEGNFLFNGNFLLSTSKKEINVQGTRTVIEYSGSNN 803
Query: 814 RDDFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSH 873
+ ++ + ++ LI+Q+L DV YSF +P + +
Sbjct: 804 AVERINST--NRQEKELILQVLCVGNLYNPDVHYSFNIPLE-------------ERSDMF 848
Query: 874 TSQPQWVTGPWLACSRTCDTGWHTRTVQC 902
T P GPW C++ C G R + C
Sbjct: 849 TWDPY---GPWEGCTKMCQ-GLQRRNITC 873
Score = 51.2 bits (121), Expect = 4e-06
Identities = 26/87 (29%), Positives = 38/87 (43%), Gaps = 3/87 (3%)
Query: 839 PTKPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTR 898
P+ P+ Y + P + + + V QW TGPW +CS +C G R
Sbjct: 1271 PSSPVQPSYYL---STNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHR 1327
Query: 899 TVQCQDGNRKLAKGCPLSQRPSAFKQC 925
V CQD N + A C + +P +QC
Sbjct: 1328 AVVCQDENGQSASYCDAASKPPELQQC 1354
Score = 42.0 bits (97), Expect = 0.003
Identities = 20/56 (35%), Positives = 29/56 (51%), Gaps = 2/56 (3%)
Query: 877 PQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAK--GCPLSQRPSAFKQCLLKKC 930
PQW G W CS+TC G +R V CQ N ++ + C + +P + QC + C
Sbjct: 1360 PQWNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHAC 1415
Score = 38.5 bits (88), Expect = 0.029
Identities = 20/58 (34%), Positives = 28/58 (48%), Gaps = 9/58 (15%)
Query: 879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKG------CPLSQRPSAFKQCLLKKC 930
W GPW C+ TC G+ R V+C + +LA C + RPS + C+L C
Sbjct: 1080 WQVGPWGPCTTTCGHGYQMRDVKCVN---ELASAVLEDTECHEASRPSDRQSCVLTPC 1134
Score = 37.7 bits (86), Expect = 0.050
Identities = 20/57 (35%), Positives = 23/57 (40%), Gaps = 1/57 (1%)
Query: 875 SQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKG-CPLSQRPSAFKQCLLKKC 930
S P W W C TC G R V CQ L+ G C S +P + C L C
Sbjct: 1021 SCPSWAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTC 1077
Score = 37.4 bits (85), Expect = 0.065
Identities = 47/206 (22%), Positives = 69/206 (33%), Gaps = 41/206 (19%)
Query: 476 PRKQILGPEELPGQTYDATQQCNLTFG----PEYSVC--PGMDVCARLWCAVVRQGQMV- 528
P Q GP P Y +C+ T G +C P + C +V + V
Sbjct: 1349 PELQQCGPGPCPQWNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPSVI 1408
Query: 529 -CLTKKLPAVEG----------TPCGKGRICLQGKCVDKTKKKYYSTSSHG--------- 568
C PA CGKGR + C+D+ ++K T+
Sbjct: 1409 QCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKA 1468
Query: 569 ----NWGSW--GSWGQCSRSCGGGVQFAYRHCN--------NPAPRNNGRYCTGKRAIYR 614
SW SW +CS +CG GVQ +C + R C+ +R +
Sbjct: 1469 CRSVRCPSWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQ 1528
Query: 615 SCSLMPCPPNGKSFRHEQCEAKNGYQ 640
C G+ CE K+ +Q
Sbjct: 1529 DCVQHKGMERGRLNCSTSCERKDSHQ 1554
Score = 37.0 bits (84), Expect = 0.085
Identities = 21/60 (35%), Positives = 26/60 (43%), Gaps = 3/60 (5%)
Query: 565 SSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYC--TGKRAIYRSCSLMPCP 622
S GN G WG CS SC GG+Q C + + + YC K + C PCP
Sbjct: 1302 SVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQ-SASYCDAASKPPELQQCGPGPCP 1360
Score = 36.6 bits (83), Expect = 0.11
Identities = 23/63 (36%), Positives = 28/63 (44%), Gaps = 8/63 (12%)
Query: 567 HGN-----WGSWGSWGQCSRSCGGGVQFAYRHC-NNPAPRNNGRYCTG-KRAIYRSCSLM 619
HGN W + W QCSRSCGGG + +C NN R C R +C+
Sbjct: 962 HGNCVFTRW-HYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVTRENCNEF 1020
Query: 620 PCP 622
CP
Sbjct: 1021 SCP 1023
Score = 36.2 bits (82), Expect = 0.15
Identities = 17/54 (31%), Positives = 26/54 (48%), Gaps = 1/54 (1%)
Query: 878 QWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKG-CPLSQRPSAFKQCLLKKC 930
+W G W CS +C G TR V C + ++ + + C RP ++C L C
Sbjct: 1210 EWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAAC 1263
Score = 35.8 bits (81), Expect = 0.19
Identities = 21/62 (33%), Positives = 25/62 (40%), Gaps = 4/62 (6%)
Query: 571 GSW--GSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTG--KRAIYRSCSLMPCPPNGK 626
G W G W CS SCG G C N + YC + + + CSL CPP
Sbjct: 1209 GEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAACPPAHS 1268
Query: 627 SF 628
F
Sbjct: 1269 HF 1270
Score = 35.4 bits (80), Expect = 0.25
Identities = 20/54 (37%), Positives = 24/54 (44%), Gaps = 2/54 (3%)
Query: 879 WVTGPWLACSRTCDTGWHTRTVQCQDG-NRKLA-KGCPLSQRPSAFKQCLLKKC 930
W PW +CS +C G R V C D RKL C Q+P K C +C
Sbjct: 1421 WHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRC 1474
Score = 35.4 bits (80), Expect = 0.25
Identities = 17/56 (30%), Positives = 26/56 (46%), Gaps = 2/56 (3%)
Query: 877 PQWVTGPWLACSRTCDTGWHTRTVQC--QDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
P W W CS TC +G R V C + + + + C S RP + ++C + C
Sbjct: 1475 PSWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDC 1530
Score = 34.7 bits (78), Expect = 0.42
Identities = 17/52 (32%), Positives = 22/52 (42%)
Query: 879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
W G W CS TC G R V+C + + C +P A K+C C
Sbjct: 1658 WKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGAQKKCYANDC 1709
Score = 34.3 bits (77), Expect = 0.55
Identities = 17/50 (34%), Positives = 22/50 (44%), Gaps = 2/50 (4%)
Query: 878 QWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLA--KGCPLSQRPSAFKQC 925
QW G W CS +C G R V C+D ++A C RP+ C
Sbjct: 1155 QWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPRPAEIWDC 1204
Score = 33.1 bits (74), Expect = 1.2
Identities = 22/77 (28%), Positives = 30/77 (38%), Gaps = 6/77 (7%)
Query: 551 GKCVDKTKKKYYSTSSHGNWGSW--GSWGQCSRSCGGGVQFAYRHCNNPAP----RNNGR 604
G C TK + S SW G WG C+ +CG G Q C N +
Sbjct: 1058 GFCNSSTKPESLSPCELHTCASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTEC 1117
Query: 605 YCTGKRAIYRSCSLMPC 621
+ + + +SC L PC
Sbjct: 1118 HEASRPSDRQSCVLTPC 1134
Score = 30.8 bits (68), Expect = 6.1
Identities = 13/27 (48%), Positives = 14/27 (51%)
Query: 574 GSWGQCSRSCGGGVQFAYRHCNNPAPR 600
GSW CS SCG G Q Y C + R
Sbjct: 1159 GSWTPCSVSCGRGTQARYVSCRDALDR 1185
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif,
9 preproprotein [Homo sapiens]
Length = 1935
Score = 551 bits (1419), Expect = e-156
Identities = 310/795 (38%), Positives = 420/795 (52%), Gaps = 60/795 (7%)
Query: 129 HCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGRVYGDGSAR 188
HCFY+G V+ + AV LC G+ G F Y ++PL E+E+ +
Sbjct: 149 HCFYKGYVNTNSEHTAVISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQ----NKPH 204
Query: 189 ILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHS---------------NPSGRAA 233
I +Y R E R +C+T EH HS N +G A
Sbjct: 205 I--IYRRSAPQREPSTGRHACDTS-------EHKNRHSKDKKKTRARKWGERINLAGDVA 255
Query: 234 LASQLLDQSALSPAGGSGPQT----WWRRRRRSISRARQVELLLVADASMARLYGRGLQH 289
+ L A S G T RR +R +S R VE+L+VAD M +G LQH
Sbjct: 256 ALNSGLATEAFSAYGNKTDNTREKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGENLQH 315
Query: 290 YLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHN 349
Y+LTL SI +Y SI N I + +V ++V+ ++ +S NA TTLKNFC+WQH N
Sbjct: 316 YILTLMSIVASIYKDPSIGNLINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKN 375
Query: 350 QLGDDHEEHYDAAILFTREDLC-GHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTV 408
G H +D A+L TR+D+C H CDTLG+A++GTIC P RSC++ ED GL AFT+
Sbjct: 376 SPGGIH---HDTAVLLTRQDICRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTI 432
Query: 409 AHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGH 468
AHE+GH+ + HDD+ C+E G + +M+ L WSKC+ ITEFLD G+
Sbjct: 433 AHELGHVFNMPHDDNNKCKEE-GVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGY 491
Query: 469 GNCLLDLPRKQILG-PEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQM 527
G CLL+ P + P +LPG Y+ +QC L FGP VCP M C RLWC V
Sbjct: 492 GECLLNEPESRPYPLPVQLPGILYNVNKQCELIFGPGSQVCPYMMQCRRLWCNNVNGVHK 551
Query: 528 VCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGV 587
C T+ P +GT C G+ C G CV K + G+WGSW +G CSR+CGGG+
Sbjct: 552 GCRTQHTPWADGTECEPGKHCKYGFCVPKEMDV---PVTDGSWGSWSPFGTCSRTCGGGI 608
Query: 588 QFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVK 647
+ A R CN P P+N G+YC G+R ++SC+ PC + FR EQC +G + G+
Sbjct: 609 KTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLL 668
Query: 648 TFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTG 707
V WVPKY+G+L D CKL CR G Y +V DGT C +N +CV+G C + G
Sbjct: 669 PNVRWVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAG 728
Query: 708 CDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKD 767
CD ++ SK + DKCGVCGGDNSSC + GTFN GY VVRIP GAT+I VRQ
Sbjct: 729 CDHVLNSKARRDKCGVCGGDNSSCKTVAGTFNTVHYGYNTVVRIPAGATNIDVRQHSFSG 788
Query: 768 QTRFTAYLALKKKNGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATK 827
+T YLAL GE+L+NG ++++ ++ I I V+ YSG + ++ +
Sbjct: 789 ETDDDNYLALSSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINST--DRIE 846
Query: 828 EILIVQILATDPTKPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLAC 887
+ L++Q+L+ DVRYSF +P + P+ SH GPW AC
Sbjct: 847 QELLLQVLSVGKLYNPDVRYSFNIPIEDKPQQFYWNSH----------------GPWQAC 890
Query: 888 SRTCDTGWHTRTVQC 902
S+ C G R + C
Sbjct: 891 SKPCQ-GERKRKLVC 904
Score = 50.4 bits (119), Expect = 7e-06
Identities = 87/371 (23%), Positives = 128/371 (34%), Gaps = 53/371 (14%)
Query: 570 WGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTG--KRAIYRSCSLMPCPPNGKS 627
W S G W +C +CG G + C R N R C K ++C C + ++
Sbjct: 1056 WKS-GDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPECA-SWQA 1113
Query: 628 FRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFS---PKV 684
QC G + VK + Y V+ + C R T + S P
Sbjct: 1114 GPWGQCSVTCGQGYQLRAVKCIIG---TYMSVVDDNDCNAATRPTDTQDCELPSCHPPPA 1170
Query: 685 TDGTECRLYSNSVCVRGKCVRTGCDGIIG--SKLQYDKCGVCGG---DNSSCTKIVGTFN 739
T YS T C G ++++Y C G D S+C +
Sbjct: 1171 APETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRPVA 1230
Query: 740 KKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETII 799
K+ T P G Q+KA D + + + + + ++ S+ +I
Sbjct: 1231 KEECSVT-----PCG-------QWKALDWSSCSVTCGQGRATRQVMC-----VNYSDHVI 1273
Query: 800 DINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVPKKSTPKV 859
D + +Y + +D S + LA P + D R P+ ++P
Sbjct: 1274 DRSECDQDYIPETDQD-----CSMSPCPQRTPDSGLAQHPFQNEDYR-----PRSASPSR 1323
Query: 860 NSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRP 919
V G N QW TGPW ACS TC G R V CQD N A C +P
Sbjct: 1324 THVL--GGN---------QWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKP 1372
Query: 920 SAFKQCLLKKC 930
+ C C
Sbjct: 1373 DEQRACESGPC 1383
Score = 41.6 bits (96), Expect = 0.003
Identities = 20/56 (35%), Positives = 27/56 (48%), Gaps = 2/56 (3%)
Query: 877 PQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAK--GCPLSQRPSAFKQCLLKKC 930
P+W G W CS +C G R V CQ G K+A+ C RP + + C +C
Sbjct: 1499 PKWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRC 1554
Score = 40.8 bits (94), Expect = 0.006
Identities = 20/56 (35%), Positives = 26/56 (46%), Gaps = 2/56 (3%)
Query: 877 PQWVTGPWLACSRTCDTGWHTRTVQCQ--DGNRKLAKGCPLSQRPSAFKQCLLKKC 930
PQW G W C++ C G TR V CQ +G R C + +P +QC C
Sbjct: 1384 PQWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHAC 1439
Score = 40.4 bits (93), Expect = 0.008
Identities = 19/55 (34%), Positives = 27/55 (49%), Gaps = 1/55 (1%)
Query: 877 PQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKL-AKGCPLSQRPSAFKQCLLKKC 930
PQW +G W C TC G R V CQ G +L + C +P++ + C +C
Sbjct: 1054 PQWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPEC 1108
Score = 40.4 bits (93), Expect = 0.008
Identities = 19/54 (35%), Positives = 26/54 (48%), Gaps = 2/54 (3%)
Query: 879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKG--CPLSQRPSAFKQCLLKKC 930
W W C++TC G R V C D N+ G C +S+RP + C L+ C
Sbjct: 1559 WRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
Score = 39.7 bits (91), Expect = 0.013
Identities = 25/83 (30%), Positives = 38/83 (45%), Gaps = 16/83 (19%)
Query: 553 CVDKTKKKYYSTSSHGNWGSW--GSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKR 610
CV++ K G W G+WG+C++ CGGG++ C R+N G+R
Sbjct: 1366 CVERIKPDEQRACESGPCPQWAYGNWGECTKLCGGGIRTRLVVCQ----RSN-----GER 1416
Query: 611 AIYRSCSLMPCPPNGKSFRHEQC 633
SC ++ PP+ EQC
Sbjct: 1417 FPDLSCEILDKPPD-----REQC 1434
Score = 39.7 bits (91), Expect = 0.013
Identities = 18/54 (33%), Positives = 27/54 (50%), Gaps = 2/54 (3%)
Query: 879 WVTGPWLACSRTCDTGWHTRTVQC--QDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
W TGPW +CS +C G R V C +DG+ + C +P ++C +C
Sbjct: 1445 WSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRC 1498
Score = 38.1 bits (87), Expect = 0.038
Identities = 20/61 (32%), Positives = 27/61 (44%), Gaps = 10/61 (16%)
Query: 879 WVTGPWLACSRTCDTGWHTRTVQCQ---------DGNRKLAKGCPLSQRPSAFKQCLLKK 929
W+TG W CS TC G+ R V C + + + CP +Q PS C L+
Sbjct: 1616 WITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSV-HPCYLRD 1674
Query: 930 C 930
C
Sbjct: 1675 C 1675
Score = 37.7 bits (86), Expect = 0.050
Identities = 47/188 (25%), Positives = 58/188 (30%), Gaps = 50/188 (26%)
Query: 553 CVDKTKKKYYSTSSHGNWGSW--GSWGQCSRSCGGGVQFA-------------------- 590
C +TK T SW G WGQCS +CG G Q
Sbjct: 1091 CDPETKPTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNA 1150
Query: 591 ------YRHCNNP-------APRNNGRYCTGKRAIYRSCSLMPCPP---NGKSFRHEQCE 634
+ C P AP + R +R S PC G R+ C
Sbjct: 1151 ATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCR 1210
Query: 635 AKNGYQSDAKGVKTFVEWVPK-YAGVLPA--------DVCKLTC---RAKGTGYYVVFSP 682
+NG +D T V K V P C +TC RA V +S
Sbjct: 1211 DENGSVADESACATLPRPVAKEECSVTPCGQWKALDWSSCSVTCGQGRATRQVMCVNYSD 1270
Query: 683 KVTDGTEC 690
V D +EC
Sbjct: 1271 HVIDRSEC 1278
Score = 36.2 bits (82), Expect = 0.15
Identities = 23/64 (35%), Positives = 30/64 (46%), Gaps = 8/64 (12%)
Query: 565 SSHGNWGSW--GSWGQCSRSCGGGVQFAYRHCNNPAPRN---NGRYCTGKRAI-YRSCSL 618
S N G W +W +CS+SC GG Q C N RN + CT + + + CS
Sbjct: 993 SGECNTGGWRYSAWTECSKSCDGGTQRRRAICVN--TRNDVLDDSKCTHQEKVTIQRCSE 1050
Query: 619 MPCP 622
PCP
Sbjct: 1051 FPCP 1054
Score = 34.7 bits (78), Expect = 0.42
Identities = 22/77 (28%), Positives = 34/77 (44%), Gaps = 5/77 (6%)
Query: 548 CLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHC--NNPAPRNNGRY 605
C +T++ YS + W +GSW CS +CG G + Y C N + +
Sbjct: 1165 CHPPPAAPETRRSTYS-APRTQW-RFGSWTPCSATCGKGTRMRYVSCRDENGSVADESAC 1222
Query: 606 CTGKRAIYR-SCSLMPC 621
T R + + CS+ PC
Sbjct: 1223 ATLPRPVAKEECSVTPC 1239
Score = 33.1 bits (74), Expect = 1.2
Identities = 15/47 (31%), Positives = 21/47 (44%)
Query: 879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQC 925
W G W +CS +C G R+VQC + + C +P K C
Sbjct: 1681 WRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTC 1727
Score = 30.8 bits (68), Expect = 6.1
Identities = 20/60 (33%), Positives = 23/60 (38%), Gaps = 9/60 (15%)
Query: 568 GNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTG-----KRAIYRSCSLMPCP 622
GN G WG CS +C GG Q C + NG K R+C PCP
Sbjct: 1329 GNQWRTGPWGACSSTCAGGSQRRVVVCQD----ENGYTANDCVERIKPDEQRACESGPCP 1384
Score = 30.8 bits (68), Expect = 6.1
Identities = 37/150 (24%), Positives = 57/150 (38%), Gaps = 30/150 (20%)
Query: 574 GSWGQCSRSCGGGVQFAYRHCN------------NPAPR-NNGRYCTGKRA---IYRSCS 617
G+W QCS SCG GVQ + C NP R + R C G R +R+
Sbjct: 1504 GAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYTWRAEE 1563
Query: 618 LMPCPPN-GKSFRHEQCEAKNGYQSDAKGVKTFVEWVP---KYAGVLPADV--------- 664
C G+ R+ + + +++ G + V P + + P +
Sbjct: 1564 WQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEYVWITGEWSE 1623
Query: 665 CKLTCRAKGTGYYVVFSPKVTDGTECRLYS 694
C +TC KG +V ++ G E YS
Sbjct: 1624 CSVTC-GKGYKQRLVSCSEIYTGKENYEYS 1652
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif,
6 preproprotein [Homo sapiens]
Length = 1117
Score = 452 bits (1162), Expect = e-127
Identities = 298/871 (34%), Positives = 429/871 (49%), Gaps = 81/871 (9%)
Query: 86 KVGYLVYAGGRRFLLDLERDGSVGIAGFVPAGGGTSAP-WRHR--SHCFYRGTV-DGSPR 141
K+ + + A G+ F L+L + F G P W+H +C Y G + D
Sbjct: 84 KLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDGPQWKHDFLDNCHYTGYLQDQRST 143
Query: 142 SLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGRVYGDGSARILHVYTREGFSFE 201
+ C GL G A + Y ++PL E+ K Y +G ++ +
Sbjct: 144 TKVALSNCVGLHGVIATEDEEYFIEPLKNT--TEDSKHFSYENGHPHVI-------YKKS 194
Query: 202 ALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLDQSALSPAGGSGPQTWWRRRRR 261
AL R ++H+ + R+ L D S +S + R++R
Sbjct: 195 ALQQR----------HLYDHSHCGVSDFTRSGKPWWLNDTSTVSYSLPINNTHIHHRQKR 244
Query: 262 SISRARQVELLLVADASMARLYGR-GLQHYLLTLASIANRLYSHASIENHIRLAVVKVVV 320
S+S R VE L+VAD M +GR ++HY+L++ +I +LY +S+ N + + V +++V
Sbjct: 245 SVSIERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIV 304
Query: 321 LGDKDKSLEVSKNAATTLKNFCKWQ-----HQH--NQLGDDHEEHYDAAILFTREDLCGH 373
L + +LE++ +A +L +FCKWQ HQ N + ++ H+D A+L TR D+C +
Sbjct: 305 LTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTY 364
Query: 374 HS--CDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFG 431
+ C TLG+A V +C PERSC++ ED GL +AFT+AHEIGH G++HD T G
Sbjct: 365 KNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKG 424
Query: 432 STEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCL-LDLPRKQILGPEELPGQT 490
E +LM++ +T+ WS C+ IT FLD G G CL + P++ L P PGQ
Sbjct: 425 H-EAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQV 483
Query: 491 YDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRI--- 547
YDA +QC +G C +VC LWC C+T +PA EGT C G I
Sbjct: 484 YDADEQCRFQYGATSRQCKYGEVCRELWCLSKSNR---CVTNSIPAAEGTLCQTGNIEKG 540
Query: 548 -CLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYC 606
C QG CV + S G WG W WG+CSR+CGGGV + RHC++PAP G+YC
Sbjct: 541 WCYQGDCVPFGT---WPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYC 597
Query: 607 TGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVP-KYAGVLPADVC 665
G+R YRSC+ PCP + FR +QC + K + W P GV P C
Sbjct: 598 LGERKRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGK----YYNWKPYTGGGVKP---C 650
Query: 666 KLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCG 725
L C A+G +Y +P V DGT+C S +C+ G+C GCD I+GS + D+C VCG
Sbjct: 651 ALNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCG 710
Query: 726 GDNSSCTKIVGTFNKK--SKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGE 783
GD S+C I G FN GY +VV+IP G+ HI+VR+ Y+ALK + +
Sbjct: 711 GDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKN-----YIALKSEGDD 765
Query: 784 YLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKPL 843
Y ING + I D+ GT +Y + + L +G T E LIV +L + + L
Sbjct: 766 YYINGAWTIDWPRK-FDVAGTAFHYKRPTDEPESLEALG--PTSENLIVMVLLQE--QNL 820
Query: 844 DVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQ 903
+RY F VP + T G N+VG W PW CS TC G + V C+
Sbjct: 821 GIRYKFNVP-------ITRTGSGDNEVGF-----TWNHQPWSECSATCAGGVQRQEVVCK 868
Query: 904 --DGNRKLAKGC--PLSQRPSAFKQCLLKKC 930
D N + P S+ P + C + C
Sbjct: 869 RLDDNSIVQNNYCDPDSKPPENQRACNTEPC 899
Score = 48.1 bits (113), Expect = 4e-05
Identities = 26/74 (35%), Positives = 34/74 (45%), Gaps = 6/74 (8%)
Query: 852 PKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAK 911
P++S P V S G P+WVTG W CS C G RTVQC + +
Sbjct: 1001 PEESKPPVRIRCSLG------RCPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASS 1054
Query: 912 GCPLSQRPSAFKQC 925
C + RP + +QC
Sbjct: 1055 DCLETVRPPSMQQC 1068
Score = 37.0 bits (84), Expect = 0.085
Identities = 18/57 (31%), Positives = 25/57 (43%), Gaps = 3/57 (5%)
Query: 877 PQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKL---AKGCPLSQRPSAFKQCLLKKC 930
PQWV W C+ C G+ R V C+ + A CP +P +C L +C
Sbjct: 961 PQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRC 1017
Score = 34.3 bits (77), Expect = 0.55
Identities = 20/55 (36%), Positives = 27/55 (49%), Gaps = 9/55 (16%)
Query: 576 WGQCSRSCGGGVQFAYRHC----NNPAPRNNGRYC---TGKRAIYRSCSLMPCPP 623
W +CS +C GGVQ C +N +NN YC + R+C+ PCPP
Sbjct: 849 WSECSATCAGGVQRQEVVCKRLDDNSIVQNN--YCDPDSKPPENQRACNTEPCPP 901
Score = 32.0 bits (71), Expect = 2.7
Identities = 42/189 (22%), Positives = 75/189 (39%), Gaps = 31/189 (16%)
Query: 450 KPWSKCTSA---------TITEFLDDGHGNCLLDLPRKQILGPEELPGQTYDA--TQQCN 498
+PWS+C++ + + LDD + + P+ P + A T+ C
Sbjct: 847 QPWSECSATCAGGVQRQEVVCKRLDDN------SIVQNNYCDPDSKPPENQRACNTEPCP 900
Query: 499 LTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTK 558
PE+ + ++ C++ +R ++C+ K P+ E T G CL + V+K
Sbjct: 901 ----PEWFIGDWLE-CSKTCDGGMRTRAVLCIRKIGPSEEETLDYSG--CLTHRPVEK-- 951
Query: 559 KKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNP--APRNNGRYC--TGKRAIYR 614
+ + S W + W +C+ CG G + C + + C K +
Sbjct: 952 EPCNNQSCPPQWVAL-DWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRI 1010
Query: 615 SCSLMPCPP 623
CSL CPP
Sbjct: 1011 RCSLGRCPP 1019
Score = 30.8 bits (68), Expect = 6.1
Identities = 19/71 (26%), Positives = 30/71 (42%), Gaps = 6/71 (8%)
Query: 574 GSWGQCSRSCGGGVQFAYRHC---NNPAPRNNGRY--CTGKRAIYRS-CSLMPCPPNGKS 627
G W +CS++C GG++ C P+ Y C R + + C+ CPP +
Sbjct: 906 GDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWVA 965
Query: 628 FRHEQCEAKNG 638
+C K G
Sbjct: 966 LDWSECTPKCG 976
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 399 bits (1026), Expect = e-111
Identities = 289/912 (31%), Positives = 414/912 (45%), Gaps = 126/912 (13%)
Query: 61 PHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDGSVGIAGFVPAGGGT 120
P P ++RR G ++ Y V + FLL+L R + +AG V T
Sbjct: 58 PPPPRRQRRGTGATAE--------SRLFYKVASPSTHFLLNLTRSSRL-LAGHVSVEYWT 108
Query: 121 --SAPWRH--RSHCFYRGTVDG-SPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAE 175
W+ R HC Y G + G + S CGGL G Y ++PL GP
Sbjct: 109 REGLAWQRAARPHCLYAGHLQGQASTSHVAISTCGGLHGLIVADEEEYLIEPLHGGPKGS 168
Query: 176 ---EEKGR--VYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSG 230
EE G VY S R H+ T G + P P
Sbjct: 169 RSPEESGPHVVYKRSSLRHPHLDTACG--------------------VRDEKPWKGRPWW 208
Query: 231 RAALASQLLDQSALSPAGGSGPQTWWRRR--RRSISRARQVELLLVADASMARLYGR-GL 287
L PA G +T + +RS+SR R VE L+VAD M +GR +
Sbjct: 209 LRTLKPP--------PARPLGNETERGQPGLKRSVSRERYVETLVVADKMMVAYHGRRDV 260
Query: 288 QHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQ 347
+ Y+L + +I +L+ +S+ + + + V ++++L + +LE++ +A +L +FCKWQ
Sbjct: 261 EQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKS 320
Query: 348 -------HNQLGDDHEEHYDAAILFTREDLCGHHS--CDTLGMADVGTICSPERSCAVIE 398
N + ++ ++D A+L TR D+C + + C TLG+A VG +C ERSC+V E
Sbjct: 321 IVNHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGTLGLAPVGGMCERERSCSVNE 380
Query: 399 DDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSA 458
D GL AFT+AHEIGH G++HD G + +LM++ +T WS C+
Sbjct: 381 DIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQ-DPAKLMAAHITMKTNPFVWSSCSRD 439
Query: 459 TITEFLDDGHGNCLLDLP-RKQILGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARL 517
IT FLD G G CL + P R+ + P PGQ YDA +QC G + C +VC+ L
Sbjct: 440 YITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQCKYGEVCSEL 499
Query: 518 WCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSS--HGNWGSWGS 575
WC C+T +PA EGT C I +G C + + S G WG W
Sbjct: 500 WCLSKSNR---CITNSIPAAEGTLCQTHTID-KGWCYKRVCVPFGSRPEGVDGAWGPWTP 555
Query: 576 WGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEA 635
WG CSR+CGGGV + RHC++P P G+YC G+R +RSC+ CPP + FR QC
Sbjct: 556 WGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQDFREVQCSE 615
Query: 636 KNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSN 695
+ K F +W G + A C LTC A+G +Y + V DGT CR +
Sbjct: 616 FDSIPFRGK----FYKWKTYRGGGVKA--CSLTCLAEGFNFYTERAAAVVDGTPCRPDTV 669
Query: 696 SVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKKS--KGYTDVVRIPE 753
+CV G+C GCD ++GS L+ DKC VCGGD S+C I G F+ S GY DVV IP+
Sbjct: 670 DICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIPK 729
Query: 754 GATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSET-IIDINGTVMNYSGWS 812
G+ HI + +D ++LALK L+ G + T + + + GT
Sbjct: 730 GSVHIFI-----QDLNLSLSHLALKGDQESLLLEG--LPGTPQPHRLPLAGTTFQLRQGP 782
Query: 813 HRDDFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVPKKSTPKVN---------SVT 863
+ L +G LIV +LA L R++ + + S P + S
Sbjct: 783 DQVQSLEALG--PINASLIVMVLARTELPALRYRFNAPIARDSLPPYSWHYAPWTKCSAQ 840
Query: 864 SHGSNKV--------------------------------GSHTSQPQWVTGPWLACSRTC 891
G ++V + P WV G W CSR+C
Sbjct: 841 CAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSC 900
Query: 892 DTGWHTRTVQCQ 903
D G +R+V CQ
Sbjct: 901 DAGVRSRSVVCQ 912
Score = 39.7 bits (91), Expect = 0.013
Identities = 17/51 (33%), Positives = 24/51 (47%)
Query: 878 QWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLK 928
+WV G W CS C G R+V+C + + C + RP +QC K
Sbjct: 1006 RWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAK 1056
Score = 37.0 bits (84), Expect = 0.085
Identities = 16/60 (26%), Positives = 27/60 (45%), Gaps = 3/60 (5%)
Query: 874 TSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLA---KGCPLSQRPSAFKQCLLKKC 930
T P+W W C+ +C G R V C+ + + C + +P A +C L++C
Sbjct: 943 TCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRC 1002
Score = 31.2 bits (69), Expect = 4.7
Identities = 31/135 (22%), Positives = 52/135 (38%), Gaps = 17/135 (12%)
Query: 497 CNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTK----KLPAVEGTPCGKGRICLQGK 552
CN P V +C+R A VR +VC + + A++ + C + R +
Sbjct: 879 CNTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEA 938
Query: 553 CVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNN--GRYCT--G 608
C + + W + W +C+ SCG G++ C + R +C+
Sbjct: 939 C--------HGPTCPPEWAAL-DWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAA 989
Query: 609 KRAIYRSCSLMPCPP 623
K C+L CPP
Sbjct: 990 KPPATMRCNLRRCPP 1004
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 397 bits (1019), Expect = e-110
Identities = 271/818 (33%), Positives = 385/818 (47%), Gaps = 91/818 (11%)
Query: 130 CFYRGTV--DGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGRVYGDGSA 187
C GTV G+ A C GL GFF + H + ++P+ + P E G
Sbjct: 139 CHLSGTVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEPVKKHPLVE---------GGY 189
Query: 188 RILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLDQSALSPA 247
VY R+ E P + + + E R L +LS
Sbjct: 190 HPHIVYRRQKVP-ETKEPTCGLKDSVNISQKQE--------LWREKWERHNLPSRSLS-- 238
Query: 248 GGSGPQTWWRRRRRSISRARQVELLLVADASMARLYG-RGLQHYLLTLASIANRLYSHAS 306
RRSIS+ R VE L+VAD M +G ++ Y+LT+ ++ L+ + S
Sbjct: 239 ------------RRSISKERWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPS 286
Query: 307 IENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFT 366
I N I + VV++++L ++++ L++ +A TL +FCKWQ N D + H+D A+L T
Sbjct: 287 IGNAIHIVVVRLILLEEEEQGLKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLT 346
Query: 367 REDLCG--HHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSK 424
R+D+C + C+TLG++ + +C P RSC + ED GL AFT+AHE+GH G+ HD +
Sbjct: 347 RKDICAGFNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKE 406
Query: 425 FCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQILGPE 484
E G +MS L WSKC+ IT FLD G G CL D+P+K+ L +
Sbjct: 407 NDCEPVG--RHPYIMSRQLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSK 464
Query: 485 EL-PGQTYDATQQCNLTFGPEYSVCPGMD-VCARLWCAVVRQGQMVCLTKKLPAVEGTPC 542
+ PG YD QC L +GP + C ++ VC LWC+V + C +K A +GT C
Sbjct: 465 VIAPGVIYDVHHQCQLQYGPNATFCQEVENVCQTLWCSV----KGFCRSKLDAAADGTQC 520
Query: 543 GKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNN 602
G+ + C+ GKC+ KK S G WG W W CSR+CG GVQ A R CNNP P+
Sbjct: 521 GEKKWCMAGKCITVGKKP---ESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFG 577
Query: 603 GRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVKT-FVEWVPKYAGVLP 661
G+YCTG+R YR C++ PC +FR QC + D K W P + P
Sbjct: 578 GKYCTGERKRYRLCNVHPCRSEAPTFRQMQCS-----EFDTVPYKNELYHWFPIFN---P 629
Query: 662 ADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNS--VCVRGKCVRTGCDGIIGSKLQYD 719
A C+L CR + V DGT C NS VC+ G C GCD I S D
Sbjct: 630 AHPCELYCRPIDGQFSEKMLDAVIDGTPCFEGGNSRNVCINGICKMVGCDYEIDSNATED 689
Query: 720 KCGVCGGDNSSCTKIVGTF-NKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALK 778
+CGVC GD SSC + F K+ GY D+ IP+GA I+V + + +LA++
Sbjct: 690 RCGVCLGDGSSCQTVRKMFKQKEGSGYVDIGLIPKGARDIRVMEIEGAGN-----FLAIR 744
Query: 779 KKNGE-YLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQIL-- 835
++ E Y +NG ++I + + GTV Y + D M T E + +Q+L
Sbjct: 745 SEDPEKYYLNGGFIIQWNGN-YKLAGTVFQY---DRKGDLEKLMATGPTNESVWIQLLFQ 800
Query: 836 ATDPTKPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGW 895
T+P ++Y + + K N V W G W CS TC TG
Sbjct: 801 VTNP----GIKYEYTIQKDGLD--NDV----------EQQMYFWQYGHWTECSVTCGTGI 844
Query: 896 HTRTVQCQDGNRKLAKGC---PLSQRPSAFKQCLLKKC 930
+T C R + K P +Q K+C K C
Sbjct: 845 RRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKAC 882
Score = 44.3 bits (103), Expect = 5e-04
Identities = 19/52 (36%), Positives = 27/52 (51%), Gaps = 3/52 (5%)
Query: 879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
W+ G W CS TC G + R V+C + ++ C QRP K+C L+ C
Sbjct: 1317 WIVGNWSECSTTCGLGAYWRRVEC---STQMDSDCAAIQRPDPAKRCHLRPC 1365
Score = 43.5 bits (101), Expect = 0.001
Identities = 22/57 (38%), Positives = 29/57 (50%), Gaps = 5/57 (8%)
Query: 879 WVTGPWLACSRTCDTGWHTRTVQC--QDGNRKLAKG---CPLSQRPSAFKQCLLKKC 930
W TG W CS +C G+ RTVQC +GN+ + C RP FK+C + C
Sbjct: 1475 WATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQAC 1531
Score = 37.4 bits (85), Expect = 0.065
Identities = 26/112 (23%), Positives = 41/112 (36%), Gaps = 20/112 (17%)
Query: 573 WGSWGQCSRSCGGGVQFAYRHCN------------NPAPRNNGRYCTGKRAIYRSCSLMP 620
+G W +CS +CG G++ HC +P + NGR + C
Sbjct: 830 YGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQ--------KKCHEKA 881
Query: 621 CPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAK 672
CPP + E C A G + K ++ + LP C+ + K
Sbjct: 882 CPPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPK 933
Score = 36.6 bits (83), Expect = 0.11
Identities = 21/67 (31%), Positives = 30/67 (44%), Gaps = 6/67 (8%)
Query: 574 GSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYC--TGKRAIYRSCSLMPCPPNGKSFRHE 631
G+W +CS SCGGGV+ C +N+ C T K C L CP + + +
Sbjct: 951 GNWSECSVSCGGGVRIRSVTC----AKNHDEPCDVTRKPNSRALCGLQQCPSSRRVLKPN 1006
Query: 632 QCEAKNG 638
+ NG
Sbjct: 1007 KGTISNG 1013
Score = 34.7 bits (78), Expect = 0.42
Identities = 15/52 (28%), Positives = 27/52 (51%), Gaps = 3/52 (5%)
Query: 879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
W G W CS +C G R+V C + + C ++++P++ C L++C
Sbjct: 948 WTVGNWSECSVSCGGGVRIRSVTCAKNH---DEPCDVTRKPNSRALCGLQQC 996
Score = 34.3 bits (77), Expect = 0.55
Identities = 27/95 (28%), Positives = 39/95 (41%), Gaps = 12/95 (12%)
Query: 544 KGRICLQGKCVDKTKKKYYSTSSHGN----WGSWGSWGQCSRSCGGGVQFAYRHCNNPAP 599
+G C G C D TK+ + S + + W + G+W CS SCGGG Q C P
Sbjct: 1446 RGVFCPGGLC-DWTKRPTSTMSCNEHLCCHWAT-GNWDLCSTSCGGGFQKRTVQC---VP 1500
Query: 600 RNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCE 634
+ + + C P PP K + C+
Sbjct: 1501 SEGNKTEDQDQCL---CDHKPRPPEFKKCNQQACK 1532
Score = 33.9 bits (76), Expect = 0.72
Identities = 12/26 (46%), Positives = 14/26 (53%)
Query: 879 WVTGPWLACSRTCDTGWHTRTVQCQD 904
W G W CSR C G+ R +QC D
Sbjct: 1368 WKVGNWSKCSRNCSGGFKIREIQCVD 1393
Score = 33.1 bits (74), Expect = 1.2
Identities = 16/47 (34%), Positives = 21/47 (44%), Gaps = 6/47 (12%)
Query: 879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQC 925
W PW CSR+C G R V C G C ++RP++ C
Sbjct: 1427 WQVEPWSQCSRSCGGGVQERGVFCPGGL------CDWTKRPTSTMSC 1467
Score = 33.1 bits (74), Expect = 1.2
Identities = 12/13 (92%), Positives = 12/13 (92%)
Query: 576 WGQCSRSCGGGVQ 588
W QCSRSCGGGVQ
Sbjct: 1432 WSQCSRSCGGGVQ 1444
Score = 31.2 bits (69), Expect = 4.7
Identities = 20/64 (31%), Positives = 26/64 (40%), Gaps = 10/64 (15%)
Query: 574 GSWGQCSRSCGGGVQFAYRHCNNPAPRNNGR--YCTGKRAIYRSCSLMPCPPNGKSFRHE 631
G+W +CSR+C GG + C + N R +C I PP S E
Sbjct: 1371 GNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGI--------PPPLSMSCNPE 1422
Query: 632 QCEA 635
CEA
Sbjct: 1423 PCEA 1426
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif,
7 preproprotein [Homo sapiens]
Length = 1686
Score = 396 bits (1018), Expect = e-110
Identities = 277/834 (33%), Positives = 386/834 (46%), Gaps = 99/834 (11%)
Query: 95 GRRFLLDLERDGSVGIAGFVP-----AGGGTSAPWRHRSHCFYRGTVDGSPRS--LAVFD 147
GR +L + + GFV G G + H C G V LA
Sbjct: 88 GRELRFNLTANQHLLAPGFVSETRRRGGLGRAHIRAHTPACHLLGEVQDPELEGGLAAIS 147
Query: 148 LCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGRVYGDGSARILHVYTREGFSFEALPPRA 207
C GL G F + + Y ++PL P G A+ VY R+ P R
Sbjct: 148 ACDGLKGVFQLSNEDYFIEPLDSAPARP---------GHAQPHVVYKRQA------PERL 192
Query: 208 SCETPASTPEAHEHAPAHSNPSGRAALASQLLDQSALSPAGGSGPQTWWRRR-----RRS 262
+ +S P + Q+ + Q W R R +RS
Sbjct: 193 AQRGDSSAP---------------STCGVQVYPELESRRERWEQRQQWRRPRLRRLHQRS 237
Query: 263 ISRARQVELLLVADASMARLYGRG-LQHYLLTLASIANRLYSHASIENHIRLAVVKVVVL 321
+S+ + VE L+VADA M +G+ ++ Y+LT+ ++ L+ SI N I + +V++V+L
Sbjct: 238 VSKEKWVETLVVADAKMVEYHGQPQVESYVLTIMNMVAGLFHDPSIGNPIHITIVRLVLL 297
Query: 322 GDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCG--HHSCDTL 379
D+++ L+++ +A TLK+FCKWQ N GD H H+D AIL TR+DLC + C+TL
Sbjct: 298 EDEEEDLKITHHADNTLKSFCKWQKSINMKGDAHPLHHDTAILLTRKDLCAAMNRPCETL 357
Query: 380 GMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLM 439
G++ V +C P RSC++ ED GL AFTVAHE+GH G+ HD S E G +M
Sbjct: 358 GLSHVAGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQHDGSGNDCEPVGKRPF--IM 415
Query: 440 SSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQILG-PEELPGQTYDATQQCN 498
S L A WS+C+ IT FLD G G CL D P K I+ P PG YD + QC
Sbjct: 416 SPQLLYDAAPLTWSRCSRQYITRFLDRGWGLCLDDPPAKDIIDFPSVPPGVLYDVSHQCR 475
Query: 499 LTFGPEYSVCPGMD-VCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKT 557
L +G + C MD VC LWC+V C +K AV+GT CG+ + CL G+CV
Sbjct: 476 LQYGAYSAFCEDMDNVCHTLWCSV----GTTCHSKLDAAVDGTRCGENKWCLSGECVPVG 531
Query: 558 KKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCS 617
+ + G W W +W CSRSCG GVQ A R C P P+ GRYC G+R +R C+
Sbjct: 532 ---FRPEAVDGGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCN 588
Query: 618 LMPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVE-WVPKYAGVLPADVCKLTCRAKGTGY 676
L CP SFRH QC DA K + WVP V P C+L CR +
Sbjct: 589 LQACPAGRPSFRHVQCS-----HFDAMLYKGQLHTWVPVVNDVNP---CELHCRPANEYF 640
Query: 677 YVVFSPKVTDGTECRLY--SNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKI 734
V DGT C S +C+ G C GCD I S D+CGVC G+ S+C +
Sbjct: 641 AEKLRDAVVDGTPCYQVRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTV 700
Query: 735 VGTFNK-KSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGE-YLINGKYMI 792
GTF + + GY DV IP GA I++++ +LAL+ ++ E Y +NG + I
Sbjct: 701 SGTFEEAEGLGYVDVGLIPAGAREIRIQEV-----AEAANFLALRSEDPEKYFLNGGWTI 755
Query: 793 STSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVP 852
+ + GT Y + R ++ + TKE + +Q+L + + Y+
Sbjct: 756 QWNGD-YQVAGTTFTY---ARRGNWENLTSPGPTKEPVWIQLLFQESNPGVHYEYTI--- 808
Query: 853 KKSTPKVNSVTSHGSNKVGSHTSQP----QWVTGPWLACSRTCDTGWHTRTVQC 902
+ G H P W GPW C+ TC G + V C
Sbjct: 809 --------------HREAGGHDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNVYC 848
Score = 38.1 bits (87), Expect = 0.038
Identities = 18/52 (34%), Positives = 24/52 (46%), Gaps = 3/52 (5%)
Query: 879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
W G W CS TC G R V+C G + C + RP ++C L+ C
Sbjct: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSGR---DEDCAPAGRPQPARRCHLRPC 1463
Score = 36.2 bits (82), Expect = 0.15
Identities = 19/57 (33%), Positives = 25/57 (43%), Gaps = 9/57 (15%)
Query: 878 QWVTGPWLACSRTCDTGWHTRTVQC---------QDGNRKLAKGCPLSQRPSAFKQC 925
QWV GPW CS C G R V+C +D ++ + P S RP + C
Sbjct: 1572 QWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
Score = 34.3 bits (77), Expect = 0.55
Identities = 17/52 (32%), Positives = 22/52 (42%), Gaps = 3/52 (5%)
Query: 879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
W G W CS TC G R V C + C +Q+P++ C L C
Sbjct: 946 WAVGNWSQCSVTCGEGTQRRNVLCTNDT---GVPCDEAQQPASEVTCSLPLC 994
Score = 34.3 bits (77), Expect = 0.55
Identities = 22/56 (39%), Positives = 23/56 (41%), Gaps = 7/56 (12%)
Query: 574 GSWGQCSRSCGGGVQFAYRHCNNP---APRNNGRYCTGKRA---IYRSCSLMPCPP 623
G WGQCS CGGGVQ C N P + C G A R C C P
Sbjct: 1576 GPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQC-GHEAWPESSRPCGTEDCEP 1630
Score = 33.9 bits (76), Expect = 0.72
Identities = 19/52 (36%), Positives = 23/52 (44%), Gaps = 1/52 (1%)
Query: 879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
W +G W CSR+C G R VQC D R L P +P K + C
Sbjct: 1466 WHSGNWSKCSRSCGGGSSVRDVQCVD-TRDLRPLRPFHCQPGPAKPPAHRPC 1516
Score = 33.1 bits (74), Expect = 1.2
Identities = 20/57 (35%), Positives = 25/57 (43%), Gaps = 6/57 (10%)
Query: 570 WGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGR--YC---TGKRAIYRSCSLMPC 621
W S G+W +CSRSCGGG C + R +C K +R C PC
Sbjct: 1466 WHS-GNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPC 1521
Score = 30.8 bits (68), Expect = 6.1
Identities = 15/52 (28%), Positives = 19/52 (36%), Gaps = 5/52 (9%)
Query: 879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
W T W CS C G R V C + C + RP+ + C C
Sbjct: 1524 WYTSSWRECSEACGGGEQQRLVTCPEPGL-----CEEALRPNTTRPCNTHPC 1570
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1
motif, 16 preproprotein [Homo sapiens]
Length = 1224
Score = 392 bits (1008), Expect = e-109
Identities = 308/1016 (30%), Positives = 437/1016 (43%), Gaps = 134/1016 (13%)
Query: 5 WASLLLCAFRLPLAAVGPAATPAQDKAGQPPTAAAAAQPRRRQGE-------EVQERAEP 57
W L A + P A+GPAA + P A +GE EV R +
Sbjct: 15 WMLLAQVAEQAPACAMGPAAAAPGSPSVPRPPPPAERPGWMEKGEYDLVSAYEVDHRGDY 74
Query: 58 PGHPHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGGRR-FLLDLERDGSVGIAGFV-- 114
H QRRR V ++ L+ L G R F +DL S+ GF+
Sbjct: 75 VSHEIMHHQRRRRAVPVSEVESLH--------LRLKGSRHDFHMDLRTSSSLVAPGFIVQ 126
Query: 115 ---PAGGGTSAPWRHRSHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRG 171
G + CFY+G++ S C GL G + A Y L+PL
Sbjct: 127 TLGKTGTKSVQTLPPEDFCFYQGSLRSHRNSSVALSTCQGLSGMIRTEEADYFLRPLPSH 186
Query: 172 -PWAEEEKGRVYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSG 230
W + GR GS+ +Y R S E P AS S H P HS+
Sbjct: 187 LSW---KLGRA-AQGSSPSHVLYKR---STEPHAPGASEVLVTSRTWELAHQPLHSSDLR 239
Query: 231 RAALASQLL--DQSALSPAGGSG-----PQTWWR--RRRRSISRARQ-----VELLLVAD 276
Q + P P + R +RS+ R+ + VE L+V D
Sbjct: 240 LGLPQKQHFCGRRKKYMPQPPKEDLFILPDEYKSCLRHKRSLLRSHRNEELNVETLVVVD 299
Query: 277 ASMARLYGR-GLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAA 335
M + +G + Y+LT+ ++ + L+ +I +I +A+V +++L D+ L +S +A
Sbjct: 300 KKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLEDEQPGLVISHHAD 359
Query: 336 TTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCG--HHSCDTLGMADVGTICSPERS 393
TL +FC+WQ +G D H D AIL T D+C + CDTLG A + +CS RS
Sbjct: 360 HTLSSFCQWQS--GLMGKDGTRH-DHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRS 416
Query: 394 CAVIEDDGLHAAFTVAHEIGHLLGLSHD-DSKFCEETFGSTEDKRLMSSILTSIDASKPW 452
C + ED GL AFT+AHE GH G+ HD + C+++ G+ +MS L + W
Sbjct: 417 CTINEDTGLGLAFTIAHESGHNFGMIHDGEGNMCKKSEGN-----IMSPTLAGRNGVFSW 471
Query: 453 SKCTSATITEFLDDGHGNCLLDLPR--KQILGPEELPGQTYDATQQCNLTFGPEYSVCP- 509
S C+ + +FL CL D P+ K+ PE+LPG+ YDA QC FG + +C
Sbjct: 472 SPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQFGEKAKLCML 531
Query: 510 --GMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSH 567
D+C LWC + + C TK +PA EGT CG C G+CV + T H
Sbjct: 532 DFKKDICKALWCHRIGRK---CETKFMPAAEGTICGHDMWCRGGQCVKYGDEGPKPT--H 586
Query: 568 GNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKS 627
G+W W SW CSR+CGGGV R C NP P + G++C G + C+ CP +
Sbjct: 587 GHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVD 646
Query: 628 FRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDG 687
FR QC N + + K W P Y V D+CKL C A+G ++ S KV DG
Sbjct: 647 FRAAQCAEHNSRRFRGRHYK----WKP-YTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDG 701
Query: 688 TECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNK--KSKGY 745
T C S +VC+ G C R GCD ++GS D CGVC G+NS+CT G + K + Y
Sbjct: 702 TPCSEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQY 761
Query: 746 TDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDINGTV 805
+V IP GA I++ + T+Y++++ Y +NG + + +GT
Sbjct: 762 YHMVTIPSGARSIRIYEMNVS-----TSYISVRNALRRYYLNGHWTVDWPGR-YKFSGTT 815
Query: 806 MNYSGWSHRDDFLHGMGYSATKEILIVQI-----------------LATDPTKPLDVRYS 848
+Y + + L G T E LIV++ L T+ P Y+
Sbjct: 816 FDYRRSYNEPENLIATG--PTNETLIVELLFQGRNPGVAWEYSMPRLGTEKQPPAQPSYT 873
Query: 849 FFVPKKS-----------------------------TPKVNSVTSHGSNKVGSHTSQPQW 879
+ + + PK VT KV + P W
Sbjct: 874 WAIVRSECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSA--CPPSW 931
Query: 880 VTGPWLACSRTCDTGWHTRTVQC-----QDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
G W ACSRTC G +R VQC D A CP PS+ + C + C
Sbjct: 932 SVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCP-QPAPSSRQACNSQSC 986
Score = 50.4 bits (119), Expect = 7e-06
Identities = 22/65 (33%), Positives = 28/65 (43%), Gaps = 6/65 (9%)
Query: 872 SHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKG------CPLSQRPSAFKQC 925
S + P W GPW CS TC GW R V C+ N C +P + C
Sbjct: 983 SQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEAC 1042
Query: 926 LLKKC 930
LL++C
Sbjct: 1043 LLQRC 1047
Score = 49.3 bits (116), Expect = 2e-05
Identities = 24/56 (42%), Positives = 29/56 (51%), Gaps = 1/56 (1%)
Query: 875 SQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
S+ W PW C+ +C G TR+VQC G R A GC L Q+PSA C C
Sbjct: 1126 SRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRP-ASGCLLHQKPSASLACNTHFC 1180
Score = 34.3 bits (77), Expect = 0.55
Identities = 19/54 (35%), Positives = 24/54 (44%), Gaps = 2/54 (3%)
Query: 571 GSW--GSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCP 622
GSW W QC+ SCGGGVQ C +G K + +C+ CP
Sbjct: 1128 GSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNTHFCP 1181
Score = 33.9 bits (76), Expect = 0.72
Identities = 29/104 (27%), Positives = 39/104 (37%), Gaps = 13/104 (12%)
Query: 572 SW--GSWGQCSRSCGGGVQFAYRHC-------NNPAPRNNGRYCTGKRAIYR-SCSLMPC 621
SW G+W CSR+CGGG Q C + P P + C R +C+ C
Sbjct: 930 SWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPAS---LCPQPAPSSRQACNSQSC 986
Query: 622 PPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVC 665
PP + +C G + V A +LP VC
Sbjct: 987 PPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVC 1030
Score = 30.4 bits (67), Expect = 8.0
Identities = 22/84 (26%), Positives = 32/84 (38%), Gaps = 19/84 (22%)
Query: 548 CLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCT 607
CL +C K KK + S+ W QCS +C G Q + C R
Sbjct: 1042 CLLQRC-HKPKKLQWLVSA---------WSQCSVTCERGTQKRFLKCAEKYVSGKYRELA 1091
Query: 608 GKRA---------IYRSCSLMPCP 622
K+ + R+C+ +PCP
Sbjct: 1092 SKKCSHLPKPSLELERACAPLPCP 1115
Score = 30.4 bits (67), Expect = 8.0
Identities = 10/27 (37%), Positives = 15/27 (55%)
Query: 878 QWVTGPWLACSRTCDTGWHTRTVQCQD 904
QW+ W CS TC+ G R ++C +
Sbjct: 1054 QWLVSAWSQCSVTCERGTQKRFLKCAE 1080
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif,
3 proprotein [Homo sapiens]
Length = 1205
Score = 377 bits (968), Expect = e-104
Identities = 265/826 (32%), Positives = 387/826 (46%), Gaps = 86/826 (10%)
Query: 127 RSHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGRVYGDGS 186
+++C Y G + P + C GL G + Y ++PL RG EEEKGR++
Sbjct: 143 QTNCAYVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMEEEKGRIHV--- 199
Query: 187 ARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLDQSALSP 246
VY R A E AP + S L L
Sbjct: 200 -----VYKRS---------------------AVEQAPIDMSKDFHYR-ESDLEGLDDLGT 232
Query: 247 AGGSGPQTW---WRRRRRSISRARQVELLLVADASMARLYGRG-LQHYLLTLASIANRLY 302
G+ Q RRRR + +E+LL D S+ R +G+ +Q+YLLTL +I N +Y
Sbjct: 233 VYGNIHQQLNETMRRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIY 292
Query: 303 SHASIENHIRLAVVKVVVLG-DKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDA 361
S+ HI + +V++++LG K SL N + +L+N C+W Q + +H EH+D
Sbjct: 293 HDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDH 352
Query: 362 AILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHD 421
AI TR+D G A V +C P RSC + +DG +AF VAHE GH+LG+ HD
Sbjct: 353 AIFLTRQDF---GPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHD 409
Query: 422 -DSKFC--EETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRK 478
C E GS +M+ ++ + WS+C+ + ++ +CLLD P
Sbjct: 410 GQGNRCGDETAMGS-----VMAPLVQAAFHRYHWSRCSGQELKRYIHSY--DCLLDDPFD 462
Query: 479 QILGP-EELPGQTYDATQQCNLTFGPEYSVCPGM---DVCARLWCAVVRQGQMVCLTKKL 534
ELPG Y +QC FG Y +C D C +LWC+ C TKK
Sbjct: 463 HDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHP-DNPYFCKTKKG 521
Query: 535 PAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHC 594
P ++GT C G+ C +G C+ K + GNWGSW +G CSR+CG GV+F R C
Sbjct: 522 PPLDGTECAAGKWCYKGHCMWKNANQQ---KQDGNWGSWTKFGSCSRTCGTGVRFRTRQC 578
Query: 595 NNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVP 654
NNP P N G+ C G Y+ C+ C + + FR +QC+ +N S + T W+P
Sbjct: 579 NNPMPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRN---SHFEYQNTKHHWLP 635
Query: 655 KYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYS-NSVCVRGKCVRTGCDGIIG 713
Y P C L C++K TG V DGT C S+CVRG+CV+ GCD IG
Sbjct: 636 -YEHPDPKKRCHLYCQSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIG 694
Query: 714 SKLQYDKCGVCGGDNSSCTKIVGTFNK--KSKGYTDVVRIPEGATHIKVRQFKAKDQTRF 771
S DKCGVCGGDNS C + GTF + + GY + IP GA H+ +++ +A
Sbjct: 695 SNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPH--- 751
Query: 772 TAYLALKKK-NGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDF--LHGMGYSATKE 828
LA+K + G Y++NGK + S T ID+ G +Y + DD LH G +
Sbjct: 752 --ILAIKNQATGHYILNGKGEEAKSRTFIDL-GVEWDY---NIEDDIESLHTDG--PLHD 803
Query: 829 ILIVQILATDPTKPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACS 888
+IV I+ + + Y + + + S P +NS +N + +W W CS
Sbjct: 804 PVIVLIIPQENDTRSSLTYKYIIHEDSVPTINS-----NNVIQEELDTFEWALKSWSQCS 858
Query: 889 RTCDTGWHTRTVQCQ---DGNRKLAKGCPLSQRPSAFKQ-CLLKKC 930
+ C G+ C+ D C +++P ++ C +++C
Sbjct: 859 KPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQEC 904
Score = 42.0 bits (97), Expect = 0.003
Identities = 20/53 (37%), Positives = 26/53 (49%), Gaps = 6/53 (11%)
Query: 878 QWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
QW TGPW CS TC G R V C+ G+ C ++P + + C L C
Sbjct: 969 QWKTGPWSECSVTCGEGTEVRQVLCRAGDH-----CD-GEKPESVRACQLPPC 1015
Score = 35.8 bits (81), Expect = 0.19
Identities = 22/78 (28%), Positives = 32/78 (41%), Gaps = 7/78 (8%)
Query: 576 WGQCSRSCGG-GVQFAYRHCNNPAPRNNGR-----YCTGKRA-IYRSCSLMPCPPNGKSF 628
W C+++CG G Q C P R YC G R R C+ +PCP K+
Sbjct: 914 WEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTG 973
Query: 629 RHEQCEAKNGYQSDAKGV 646
+C G ++ + V
Sbjct: 974 PWSECSVTCGEGTEVRQV 991
Score = 32.0 bits (71), Expect = 2.7
Identities = 17/49 (34%), Positives = 22/49 (44%), Gaps = 7/49 (14%)
Query: 574 GSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTG-KRAIYRSCSLMPC 621
G W +CS +CG G + C G +C G K R+C L PC
Sbjct: 973 GPWSECSVTCGEGTEVRQVLC------RAGDHCDGEKPESVRACQLPPC 1015
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 372 bits (954), Expect = e-102
Identities = 264/882 (29%), Positives = 385/882 (43%), Gaps = 114/882 (12%)
Query: 130 CFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGRVYGDGSARI 189
CFY+G + S C GL G + + + PL + E G +
Sbjct: 143 CFYQGFIRNDSSSSVAVSTCAGLSGLIRTRKNEFLISPLPQLLAQEHNYSSPAGHHPHVL 202
Query: 190 LHVYTREGFSFEALPPRASCETPASTPEAHEHAPA------HSNPSGRAALASQLLDQSA 243
E P + P +P HA H + + +
Sbjct: 203 YKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKYAP 262
Query: 244 LSPA----------GGSGPQTWWRRRRRSISRARQ---VELLLVADASMARLYGRG-LQH 289
P G SG R RRS ++++ VE L+VAD M +G+G +
Sbjct: 263 KPPTEDTYLRFDEYGSSG------RPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTT 316
Query: 290 YLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHN 349
Y+LT+ ++ + L+ +I + I + VV +++L + L ++ +A +L +FC+WQ +
Sbjct: 317 YILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLINHHADQSLNSFCQWQ---S 373
Query: 350 QLGDDHEEHYDAAILFTREDLCG--HHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFT 407
L + + +D AIL T D+C + CDTLG A + +CS RSC + ED GL AFT
Sbjct: 374 ALIGKNGKRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFT 433
Query: 408 VAHEIGHLLGLSHD-DSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDD 466
+AHE GH G+ HD + C + G+ +MS LT + WS C+ + +FL
Sbjct: 434 IAHESGHNFGMIHDGEGNPCRKAEGN-----IMSPTLTGNNGVFSWSSCSRQYLKKFLST 488
Query: 467 GHGNCLLDLPRK--QILGPEELPGQTYDATQQCNLTFGPEYSVCP---GMDVCARLWCAV 521
CL+D P++ Q P++LPGQ YDA QC FG + +C D+C LWC
Sbjct: 489 PQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHR 548
Query: 522 VRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSR 581
V C TK +PA EGT CG C QG+CV + HG W +W W +CSR
Sbjct: 549 VGHR---CETKFMPAAEGTVCGLSMWCRQGQCV--KFGELGPRPIHGQWSAWSKWSECSR 603
Query: 582 SCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQS 641
+CGGGV+F RHCNNP P+ G +C G IY+ C++ PC N FR +QC N
Sbjct: 604 TCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYN--SK 661
Query: 642 DAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRG 701
+G F +W P Y V D CKL C+A+ ++ S KV DGT C N VC+ G
Sbjct: 662 PFRG--WFYQWKP-YTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDG 718
Query: 702 KCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTF--NKKSKGYTDVVRIPEGATHIK 759
C GCD +GSK D CGVC GDNS+C G + K+ Y VV IP GA I+
Sbjct: 719 VCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIE 778
Query: 760 VRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLH 819
+++ + ++YLA++ + +Y + G + I GT Y +R + L+
Sbjct: 779 IQELQVS-----SSYLAVRSLSQKYYLTGGWSIDWPGE-FPFAGTTFEYQRSFNRPERLY 832
Query: 820 GMGYSATKEILIVQILATDPTKPLDVRYSFFVPKKSTP---------------------- 857
G T E L+ +IL + +Y+ TP
Sbjct: 833 APG--PTNETLVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECSVSCG 890
Query: 858 ----------------KVNSVTSHGSNK-------VGSHTSQPQWVTGPWLACSRTCDTG 894
+VNS K + + W+ G W CS+ C G
Sbjct: 891 GGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGG 950
Query: 895 WHTRTVQC------QDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
+R +QC Q L CP+S P+ + C C
Sbjct: 951 QQSRKIQCVQKKPFQKEEAVLHSLCPVS-TPTQVQACNSHAC 991
Score = 45.4 bits (106), Expect = 2e-04
Identities = 21/61 (34%), Positives = 28/61 (45%), Gaps = 2/61 (3%)
Query: 872 SHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKL--AKGCPLSQRPSAFKQCLLKK 929
SH PQW GPW CS+TC G R + C+ + C RP + C+L +
Sbjct: 988 SHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGR 1047
Query: 930 C 930
C
Sbjct: 1048 C 1048
Score = 44.7 bits (104), Expect = 4e-04
Identities = 36/135 (26%), Positives = 53/135 (39%), Gaps = 12/135 (8%)
Query: 497 CNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDK 556
CN P Y + C++ CA +Q ++K+ V+ P K L C
Sbjct: 926 CNAFSCPAYWMPGEWSTCSKA-CAGGQQ------SRKIQCVQKKPFQKEEAVLHSLCPVS 978
Query: 557 TKKKYYSTSSHGNWGSW--GSWGQCSRSCGGGVQFAYRHCNNPAPRN-NGRYCTG--KRA 611
T + + +SH W G W QCS++CG GV+ C A CT +
Sbjct: 979 TPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPE 1038
Query: 612 IYRSCSLMPCPPNGK 626
+ C L CP N +
Sbjct: 1039 LQEGCVLGRCPKNSR 1053
Score = 39.3 bits (90), Expect = 0.017
Identities = 18/52 (34%), Positives = 24/52 (46%), Gaps = 1/52 (1%)
Query: 879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
W + PW C+ TC G TR+V C R + C L Q+P + C C
Sbjct: 1127 WYSLPWQQCTVTCGGGVQTRSVHCVQQGRP-SSSCLLHQKPPVLRACNTNFC 1177
Score = 35.8 bits (81), Expect = 0.19
Identities = 16/47 (34%), Positives = 23/47 (48%)
Query: 576 WGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCP 622
W QC+ +CGGGVQ HC ++ K + R+C+ CP
Sbjct: 1132 WQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCP 1178
Score = 34.3 bits (77), Expect = 0.55
Identities = 42/188 (22%), Positives = 76/188 (40%), Gaps = 30/188 (15%)
Query: 422 DSKFCE-ETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQI 480
+S FC +T TE K + + WS C+ A G + + +K+
Sbjct: 909 NSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACA-----GGQQSRKIQCVQKKP 963
Query: 481 LGPEEL------PGQTYDATQQCNL-TFGPEYSVCPGMDVCARLWCAVVRQGQMVC---L 530
EE P T Q CN P++S+ P C++ VR+ +++C
Sbjct: 964 FQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQ-CSKTCGRGVRKRELLCKGSA 1022
Query: 531 TKKLPAVEGTPCGKGRI---CLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGV 587
+ LP + T + + C+ G+C ++ ++ ++S W +CS +CG GV
Sbjct: 1023 AETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASS----------WSECSATCGLGV 1072
Query: 588 QFAYRHCN 595
+ C+
Sbjct: 1073 RKREMKCS 1080
Score = 32.3 bits (72), Expect = 2.1
Identities = 12/30 (40%), Positives = 16/30 (53%)
Query: 875 SQPQWVTGPWLACSRTCDTGWHTRTVQCQD 904
S+ QWV W CS TC G R ++C +
Sbjct: 1052 SRLQWVASSWSECSATCGLGVRKREMKCSE 1081
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1
motif, 17 preproprotein [Homo sapiens]
Length = 1095
Score = 370 bits (951), Expect = e-102
Identities = 303/1002 (30%), Positives = 433/1002 (43%), Gaps = 174/1002 (17%)
Query: 8 LLLCAFRL-PLAAVGPAATPAQ---------DKAGQPPTAAAAAQPRRRQGEEVQERAEP 57
LLL + L P AVG AA + D PP AA RRR+ P
Sbjct: 15 LLLLVWGLDPGTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPGPRRRRRPRT------P 68
Query: 58 PGHPHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDGSVGIAGF-VPA 116
P P R + L+ ++ A GR L L RD GF V
Sbjct: 69 PAAPRA---RPGERALLLHLP--------------AFGRDLYLQLRRDLRFLSRGFEVEE 111
Query: 117 GGGTSAPWRHRSHCFYRGTVDGSPRSLAVFDLCG---GLDGFFAVKHARYTLKPL--LRG 171
G R CFY G V G P SL CG GL G + + ++PL +G
Sbjct: 112 AGAARRRGRPAELCFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQG 171
Query: 172 PWAEEEKGRVYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGR 231
P++ E H+ R+ +L P S E A PE
Sbjct: 172 PFSGRE-------------HLIRRKW----SLTPSPSAE--AQRPEQ------------- 199
Query: 232 AALASQLLDQSALSPAGGSGPQTWWRRRRRSISRARQ--VELLLVADASMARLYG-RGLQ 288
L L ++ P G P WR RR +I + VE L+VADA M + +G Q
Sbjct: 200 --LCKVLTEKK--KPTWGR-PSRDWRERRNAIRLTSEHTVETLVVADADMVQYHGAEAAQ 254
Query: 289 HYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQ- 347
++LT+ ++ ++ H S+ I + V K+V+L + L + + +L++FC WQ++
Sbjct: 255 RFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEE 314
Query: 348 --------HNQL--GDDHEEHYDAAILFTREDLCGHHS--CDTLGMADVGTICSPERSCA 395
+NQ+ G D DAA+ TR D C H CDT+G+A +G +CS +R C
Sbjct: 315 YGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCV 374
Query: 396 VIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSS--ILTSIDASKPWS 453
+ ED+GL+ AFT+AHE+GH LG++HDD + +MS + + WS
Sbjct: 375 LAEDNGLNLAFTIAHELGHNLGMNHDD-----DHSSCAGRSHIMSGEWVKGRNPSDLSWS 429
Query: 454 KCTSATITEFLDDGHGNCLLDL-PRKQ--ILGPEELPGQTYDATQQCNLTFGPEYSVCPG 510
C+ + FL CLL PR Q + P +LPG Y A +QC + FG + C
Sbjct: 430 SCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATFCRN 489
Query: 511 MD--VCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHG 568
M+ +CA LWC V +G C TK P ++GT CG + C G+CV KT + G
Sbjct: 490 MEHLMCAGLWCLV--EGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVD---G 544
Query: 569 NWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSF 628
+W WG+W CSR+CG G +F R C+NP P G +C G + C +PCP SF
Sbjct: 545 DWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSF 604
Query: 629 RHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGT 688
R +QC+A + KG+ T V V+ C+L C G ++ + +V DGT
Sbjct: 605 RDQQCQAHDRLSPKKKGLLTAV--------VVDDKPCELYCSPLGKESPLLVADRVLDGT 656
Query: 689 ECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNK------KS 742
C Y +CV GKC + GCDGIIGS + D+CGVC GD +C + G F+ K
Sbjct: 657 PCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGTALKD 716
Query: 743 KGYTDV-----VRIP-----EGATHIKVR-----QFKAKDQTRFTAYL-ALKKKNGEYLI 786
G + + +P G T VR + AK T+ +L L + +Y I
Sbjct: 717 SGKGSINSDWKIELPGEFQIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGI 776
Query: 787 NGKYMISTSETIIDINGT--------VMNYSGWSHRDDFLHG----MGYSATKEILIVQI 834
+ +Y + + T + + + +SGW G S T+ +
Sbjct: 777 HYEYTVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTT 836
Query: 835 LATDPTKPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTG 894
L D P R P+ + N H Q +WV GPW CS TC+ G
Sbjct: 837 LVNDSDCPQASR-----PEPQVRRCN-----------LHPCQSRWVAGPWSPCSATCEKG 880
Query: 895 WHTRTVQC----QDGNRKLAKG--CPLSQRPSAFKQCLLKKC 930
+ R V C Q+G + CP RP+A + C + C
Sbjct: 881 FQHREVTCVYQLQNGTHVATRPLYCP-GPRPAAVQSCEGQDC 921
Score = 46.2 bits (108), Expect = 1e-04
Identities = 19/54 (35%), Positives = 27/54 (50%), Gaps = 1/54 (1%)
Query: 878 QWVTGPWLACSRTCDTGWHTRTVQCQDG-NRKLAKGCPLSQRPSAFKQCLLKKC 930
+W TG W CS TC G +R VQC + CP +P+ ++QC + C
Sbjct: 975 EWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVC 1028
Score = 39.3 bits (90), Expect = 0.017
Identities = 49/185 (26%), Positives = 60/185 (32%), Gaps = 39/185 (21%)
Query: 451 PWSKCTSATITEFLDDGHGNCLLDLPRKQILGPEEL--PGQTYDATQQCNLTFGPEYSVC 508
PWS C SAT + C+ L + L PG A Q C
Sbjct: 869 PWSPC-SATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCE---------- 917
Query: 509 PGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGR-----ICL--QGKCVDKTKKKY 561
G D C +W A C CGKG C QGKC T+ +
Sbjct: 918 -GQD-CLSIWEA---SEWSQC---------SASCGKGVWKRTVACTNSQGKCDASTRPRA 963
Query: 562 YST-SSHGNWGSW--GSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYC--TGKRAIYRSC 616
+ W G W CS +CG G+Q C + +G C K A YR C
Sbjct: 964 EEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQC 1023
Query: 617 SLMPC 621
C
Sbjct: 1024 YQEVC 1028
Score = 34.3 bits (77), Expect = 0.55
Identities = 17/47 (36%), Positives = 20/47 (42%), Gaps = 4/47 (8%)
Query: 879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQC 925
W W CS +C G RTV C + K C S RP A + C
Sbjct: 925 WEASEWSQCSASCGKGVWKRTVACTNSQGK----CDASTRPRAEEAC 967
Score = 30.4 bits (67), Expect = 8.0
Identities = 21/71 (29%), Positives = 26/71 (36%), Gaps = 6/71 (8%)
Query: 574 GSWGQCSRSCGGGVQF-----AYRHCNNPAPRNNGRYCTGKR-AIYRSCSLMPCPPNGKS 627
G W CS +C G Q Y+ N YC G R A +SC C ++
Sbjct: 868 GPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCLSIWEA 927
Query: 628 FRHEQCEAKNG 638
QC A G
Sbjct: 928 SEWSQCSASCG 938
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 364 bits (934), Expect = e-100
Identities = 271/901 (30%), Positives = 393/901 (43%), Gaps = 152/901 (16%)
Query: 119 GTSAPWRH----------RSHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPL 168
G+S W+ R C Y G V G P + C GL G + ++PL
Sbjct: 131 GSSVEWQEDFRELFRQPLRQECVYTGGVTGMPGAAVAISNCDGLAGLIRTDSTDFFIEPL 190
Query: 169 LRGPWAEEEKGRVYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSN- 227
RG +E GR + VY RE E P + H A +
Sbjct: 191 ERGQQEKEASGRTHV--------VYRREAVQQEWAEPDG---------DLHNEAFGLGDL 233
Query: 228 PSGRAALASQLLDQSALSPAGGSGPQTWWRRRRRSISRARQVELLLVADASMARLYGRG- 286
P+ + QL D R+RR + + +E+LLV D S+ R +G+
Sbjct: 234 PNLLGLVGDQLGDTE--------------RKRRHAKPGSYSIEVLLVVDDSVVRFHGKEH 279
Query: 287 LQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDK-SLEVSKNAATTLKNFCKWQ 345
+Q+Y+LTL +I + +Y S+ HI +A+V+++++G + SL N + +L+ C+W
Sbjct: 280 VQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWA 339
Query: 346 HQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAA 405
H + H EH+D + TR+D G A V +C P RSCA+ +DG +A
Sbjct: 340 HSQQRQDPSHAEHHDHVVFLTRQDF------GPSGYAPVTGMCHPLRSCALNHEDGFSSA 393
Query: 406 FTVAHEIGHLLGLSHD-DSKFC--EETFGSTEDKRLMSSILTSIDASKPWSKCTSATITE 462
F +AHE GH+LG+ HD C E + GS +M+ ++ + WS+C+ ++
Sbjct: 394 FVIAHETGHVLGMEHDGQGNGCADETSLGS-----VMAPLVQAAFHRFHWSRCSKLELSR 448
Query: 463 FLDDGHGNCLLDLPRKQILG-PEELPGQTYDATQQCNLTFGPEYSVCPGM---DVCARLW 518
+L +CLLD P P ELPG Y +QC FG Y C + C +LW
Sbjct: 449 YLPSY--DCLLDDPFDPAWPQPPELPGINYSMDEQCRFDFGSGYQTCLAFRTFEPCKQLW 506
Query: 519 CAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQ 578
C+ C TKK P ++GT C G+ C +G C+ K+ ++ Y G W SW +G
Sbjct: 507 CSHP-DNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQD--GGWSSWTKFGS 563
Query: 579 CSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNG 638
CSRSCGGGV+ R CNNP+P GR C G Y+ C+ CP + FR +QC +N
Sbjct: 564 CSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNS 623
Query: 639 Y--QSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYS-N 695
Y +AK WVP Y A C+L C++ TG V + V DGT C
Sbjct: 624 YYVHQNAKH-----SWVP-YEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCSYRDPY 677
Query: 696 SVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKKSK--GYTDVVRIPE 753
SVC RG+CV GCD +GS DKCGVCGGDNS C + GT K SK G +V+IP
Sbjct: 678 SVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALKLVQIPA 737
Query: 754 GATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDINGTVMNYSGWSH 813
GA HI++ + + + G +++N K +TS T T M
Sbjct: 738 GARHIQIEALEKSPH----RIVVKNQVTGSFILNPKGKEATSRTF-----TAMGLEWEDA 788
Query: 814 RDDFLHGMGYSA--TKEILIVQILATDPTKPLDVRYSFFVPKKSTPKVNS---------- 861
+D + S + I I+ + T+ + Y + + + P + S
Sbjct: 789 VEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEMDT 848
Query: 862 --------------------VTSHGSNK----------VGSHTSQPQ------------- 878
T +G + + H +P+
Sbjct: 849 YEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQ 908
Query: 879 --WVTGPWLACSRTC-DTGWHTRTVQC----QDGNRKL--AKGCPLSQRPSAFKQCLLKK 929
WVT W ACSR+C G TR +QC +G K+ AK C RP A + CL
Sbjct: 909 PVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKAC-AGDRPEARRPCLRVP 967
Query: 930 C 930
C
Sbjct: 968 C 968
Score = 37.4 bits (85), Expect = 0.065
Identities = 27/72 (37%), Positives = 31/72 (43%), Gaps = 11/72 (15%)
Query: 576 WGQCSRSCGG-GVQFAYRHCNNPAPRNNGRY-------CTGKR-AIYRSCSLMPCPPNGK 626
WG CSRSCG GVQ C P +NG + C G R R C +PCP +
Sbjct: 916 WGACSRSCGKLGVQTRGIQC--LLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPAQWR 973
Query: 627 SFRHEQCEAKNG 638
QC A G
Sbjct: 974 LGAWSQCSATCG 985
Score = 35.4 bits (80), Expect = 0.25
Identities = 19/53 (35%), Positives = 21/53 (39%), Gaps = 2/53 (3%)
Query: 878 QWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
QW G W CS TC G R V C+ L G RP + C L C
Sbjct: 971 QWRLGAWSQCSATCGEGIQQRQVVCRTNANSL--GHCEGDRPDTVQVCSLPAC 1021
Score = 35.4 bits (80), Expect = 0.25
Identities = 20/52 (38%), Positives = 26/52 (50%), Gaps = 3/52 (5%)
Query: 574 GSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRA-IYRSCSLMPCPPN 624
G+W QCS +CG G+Q C A N+ +C G R + CSL C N
Sbjct: 975 GAWSQCSATCGEGIQQRQVVCRTNA--NSLGHCEGDRPDTVQVCSLPACGGN 1024
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1
motif, 14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 363 bits (933), Expect = e-100
Identities = 271/901 (30%), Positives = 393/901 (43%), Gaps = 149/901 (16%)
Query: 119 GTSAPWRH----------RSHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPL 168
G+S W+ R C Y G V G P + C GL G + ++PL
Sbjct: 131 GSSVEWQEDFRELFRQPLRQECVYTGGVTGMPGAAVAISNCDGLAGLIRTDSTDFFIEPL 190
Query: 169 LRGPWAEEEKGRVYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSN- 227
RG +E GR + VY RE E P + H A +
Sbjct: 191 ERGQQEKEASGRTHV--------VYRREAVQQEWAEPDG---------DLHNEAFGLGDL 233
Query: 228 PSGRAALASQLLDQSALSPAGGSGPQTWWRRRRRSISRARQVELLLVADASMARLYGRG- 286
P+ + QL D R+RR + + +E+LLV D S+ R +G+
Sbjct: 234 PNLLGLVGDQLGDTE--------------RKRRHAKPGSYSIEVLLVVDDSVVRFHGKEH 279
Query: 287 LQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDK-SLEVSKNAATTLKNFCKWQ 345
+Q+Y+LTL +I + +Y S+ HI +A+V+++++G + SL N + +L+ C+W
Sbjct: 280 VQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWA 339
Query: 346 HQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAA 405
H + H EH+D + TR+D G A V +C P RSCA+ +DG +A
Sbjct: 340 HSQQRQDPSHAEHHDHVVFLTRQDF---GPSGMQGYAPVTGMCHPLRSCALNHEDGFSSA 396
Query: 406 FTVAHEIGHLLGLSHD-DSKFC--EETFGSTEDKRLMSSILTSIDASKPWSKCTSATITE 462
F +AHE GH+LG+ HD C E + GS +M+ ++ + WS+C+ ++
Sbjct: 397 FVIAHETGHVLGMEHDGQGNGCADETSLGS-----VMAPLVQAAFHRFHWSRCSKLELSR 451
Query: 463 FLDDGHGNCLLDLPRKQILG-PEELPGQTYDATQQCNLTFGPEYSVCPGM---DVCARLW 518
+L +CLLD P P ELPG Y +QC FG Y C + C +LW
Sbjct: 452 YLPSY--DCLLDDPFDPAWPQPPELPGINYSMDEQCRFDFGSGYQTCLAFRTFEPCKQLW 509
Query: 519 CAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQ 578
C+ C TKK P ++GT C G+ C +G C+ K+ ++ Y G W SW +G
Sbjct: 510 CSHP-DNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQD--GGWSSWTKFGS 566
Query: 579 CSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNG 638
CSRSCGGGV+ R CNNP+P GR C G Y+ C+ CP + FR +QC +N
Sbjct: 567 CSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNS 626
Query: 639 Y--QSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYS-N 695
Y +AK WVP Y A C+L C++ TG V + V DGT C
Sbjct: 627 YYVHQNAKH-----SWVP-YEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCSYRDPY 680
Query: 696 SVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKKSK--GYTDVVRIPE 753
SVC RG+CV GCD +GS DKCGVCGGDNS C + GT K SK G +V+IP
Sbjct: 681 SVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALKLVQIPA 740
Query: 754 GATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDINGTVMNYSGWSH 813
GA HI++ + + + G +++N K +TS T T M
Sbjct: 741 GARHIQIEALEKSPH----RIVVKNQVTGSFILNPKGKEATSRTF-----TAMGLEWEDA 791
Query: 814 RDDFLHGMGYSA--TKEILIVQILATDPTKPLDVRYSFFVPKKSTPKVNS---------- 861
+D + S + I I+ + T+ + Y + + + P + S
Sbjct: 792 VEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEMDT 851
Query: 862 --------------------VTSHGSNK----------VGSHTSQPQ------------- 878
T +G + + H +P+
Sbjct: 852 YEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQ 911
Query: 879 --WVTGPWLACSRTC-DTGWHTRTVQC----QDGNRKL--AKGCPLSQRPSAFKQCLLKK 929
WVT W ACSR+C G TR +QC +G K+ AK C RP A + CL
Sbjct: 912 PVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKAC-AGDRPEARRPCLRVP 970
Query: 930 C 930
C
Sbjct: 971 C 971
Score = 37.4 bits (85), Expect = 0.065
Identities = 27/72 (37%), Positives = 31/72 (43%), Gaps = 11/72 (15%)
Query: 576 WGQCSRSCGG-GVQFAYRHCNNPAPRNNGRY-------CTGKR-AIYRSCSLMPCPPNGK 626
WG CSRSCG GVQ C P +NG + C G R R C +PCP +
Sbjct: 919 WGACSRSCGKLGVQTRGIQC--LLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPAQWR 976
Query: 627 SFRHEQCEAKNG 638
QC A G
Sbjct: 977 LGAWSQCSATCG 988
Score = 35.4 bits (80), Expect = 0.25
Identities = 19/53 (35%), Positives = 21/53 (39%), Gaps = 2/53 (3%)
Query: 878 QWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
QW G W CS TC G R V C+ L G RP + C L C
Sbjct: 974 QWRLGAWSQCSATCGEGIQQRQVVCRTNANSL--GHCEGDRPDTVQVCSLPAC 1024
Score = 35.4 bits (80), Expect = 0.25
Identities = 20/52 (38%), Positives = 26/52 (50%), Gaps = 3/52 (5%)
Query: 574 GSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRA-IYRSCSLMPCPPN 624
G+W QCS +CG G+Q C A N+ +C G R + CSL C N
Sbjct: 978 GAWSQCSATCGEGIQQRQVVCRTNA--NSLGHCEGDRPDTVQVCSLPACGGN 1027
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1
motif, 2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 346 bits (887), Expect = 7e-95
Identities = 272/885 (30%), Positives = 397/885 (44%), Gaps = 148/885 (16%)
Query: 130 CFYRGTVDGSPRSLAV-FDLCGGLDGFFAVKHARYTLKPLLRGPWAEE-EKGRVYGDGSA 187
C Y G V G + +V C GL G ++ + ++PL +G A+E E+GRV+
Sbjct: 155 CLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQGRVHV---- 210
Query: 188 RILHVYTREGFSF-----EALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLDQS 242
VY R S +AL AS ++ S A H+N S R
Sbjct: 211 ----VYRRPPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEHANSSRR----------- 255
Query: 243 ALSPAGGSGPQTWWRRRRRSISRARQVELLLVADASMARLYGRG-LQHYLLTLASIANRL 301
R RR + +E+LL D S+ + +G+ +Q YLLTL +I N +
Sbjct: 256 --------------RARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEI 301
Query: 302 YSHASIENHIRLAVVKVVVLG-DKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYD 360
Y S+ HI + +V++++L K SL N + +L+N C+W + + H+E++D
Sbjct: 302 YHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHD 361
Query: 361 AAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSH 420
AI TR+D G A V +C P RSC + +DG +AF VAHE GH+LG+ H
Sbjct: 362 HAIFLTRQDF---GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEH 418
Query: 421 D-DSKFC--EETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLP- 476
D C E GS +M+ ++ + WS+C+ ++ +L +CLLD P
Sbjct: 419 DGQGNRCGDEVRLGS-----IMAPLVQAAFHRFHWSRCSQQELSRYLHSY--DCLLDDPF 471
Query: 477 RKQILGPEELPGQTYDATQQCNLTFGPEYSVCPGM---DVCARLWCAVVRQGQMVCLTKK 533
+LPG Y +QC FG Y +C D C +LWC+ C TKK
Sbjct: 472 AHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHP-DNPYFCKTKK 530
Query: 534 LPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRH 593
P ++GT C G+ C +G C+ T G+WG+W +G CSR+CG GV+F R
Sbjct: 531 GPPLDGTMCAPGKHCFKGHCIWLTPD---ILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQ 587
Query: 594 CNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGY--QSDAKGVKTFVE 651
C+NP P N GR C+G ++ CS CP + FR EQC + Y DA+
Sbjct: 588 CDNPHPANGGRTCSGLAYDFQLCSRQDCPDSLADFREEQCRQWDLYFEHGDAQH-----H 642
Query: 652 WVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRLY-SNSVCVRGKCVRTGCDG 710
W+P + + C L C ++ TG V V DGT C + S+CVRG C + GCDG
Sbjct: 643 WLP-HEHRDAKERCHLYCESRETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDG 701
Query: 711 IIGSKLQYDKCGVCGGDNSSCTKIVGTFNK--KSKGYTDVVRIPEGATHIKVRQFKAKDQ 768
+IGS Q DKCGVCGGDNS C + GTF + K GY + IP GA H+ +++ A
Sbjct: 702 VIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSH 761
Query: 769 TRFTAYLALKK-KNGEYLINGKYMISTSETIIDINGTVMNYSGWSHRD----DFLHGMG- 822
+LA+K + G++++N + + S G W +RD + L MG
Sbjct: 762 -----HLAVKNLETGKFILNEENDVDASSKTFIAMGV-----EWEYRDEDGRETLQTMGP 811
Query: 823 YSATKEILIVQI-----------------LATDPTKPLD---VRYSFFVPK-----KSTP 857
T +L++ + L D L+ V Y + + K K
Sbjct: 812 LHGTITVLVIPVGDTRVSLTYKYMIHEDSLNVDDNNVLEEDSVVYEWALKKWSPCSKPCG 871
Query: 858 KVNSVTSHGSNKVGSH-------------------------TSQPQWVTGPWLACSRTCD 892
+ T +G + H SQP WVTG W CS+TC
Sbjct: 872 GGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCG 931
Query: 893 -TGWHTRTVQC----QDGNRKL--AKGCPLSQRPSAFKQCLLKKC 930
TG R+V+C D + AK C RP + + C + C
Sbjct: 932 RTGMQVRSVRCIQPLHDNTTRSVHAKHCN-DARPESRRACSRELC 975
Score = 38.1 bits (87), Expect = 0.038
Identities = 18/53 (33%), Positives = 23/53 (43%), Gaps = 2/53 (3%)
Query: 878 QWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
+W GPW CS TC G R V C+ + G +RP + C L C
Sbjct: 978 RWRAGPWSQCSVTCGNGTQERPVLCRTADDSF--GICQEERPETARTCRLGPC 1028
Score = 34.7 bits (78), Expect = 0.42
Identities = 21/57 (36%), Positives = 26/57 (45%), Gaps = 2/57 (3%)
Query: 568 GNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPN 624
G W + G W QCS +CG G Q C A + G + R+C L PCP N
Sbjct: 977 GRWRA-GPWSQCSVTCGNGTQERPVLCRT-ADDSFGICQEERPETARTCRLGPCPRN 1031
Score = 31.2 bits (69), Expect = 4.7
Identities = 21/72 (29%), Positives = 30/72 (41%), Gaps = 7/72 (9%)
Query: 574 GSWGQCSRSCG-GGVQFAYRHCNNPAPRN-----NGRYCTGKR-AIYRSCSLMPCPPNGK 626
G W CS++CG G+Q C P N + ++C R R+CS CP +
Sbjct: 921 GEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRELCPGRWR 980
Query: 627 SFRHEQCEAKNG 638
+ QC G
Sbjct: 981 AGPWSQCSVTCG 992
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1
motif, 19 preproprotein [Homo sapiens]
Length = 1207
Score = 340 bits (871), Expect = 5e-93
Identities = 262/904 (28%), Positives = 385/904 (42%), Gaps = 125/904 (13%)
Query: 36 TAAAAAQPRRRQGEEVQERAEPPGHPHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGG 95
+ AAA P + +PP P P G +V + A
Sbjct: 127 SGAAALSPGAPASWQPPPPPQPPPSPPPAQHAEPD-------------GDEVLLRIPAFS 173
Query: 96 RRFLLDLERDGSVGIAGFV------PAGGGTSA------PWRHRSHCFYRGTVDGSPRSL 143
R L L RDG F P G T A P + CFY G V P SL
Sbjct: 174 RDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPDAGCFYTGAVLRHPGSL 233
Query: 144 AVFDLCGG-LDGFFAVKHARYTLKPLLRGPWAEEEKGRVYGDGSARILHVYTREGFSFEA 202
A F CGG L GF + ++PL + +
Sbjct: 234 ASFSTCGGGLMGFIQLNEDFIFIEPL--------------------------NDTMAITG 267
Query: 203 LPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLDQSALSPAGGSGPQTWWRRRRRS 262
P R + + + E + HS+ G ++ + +S G G +R
Sbjct: 268 HPHRVYRQKRSMEEKVTEKSALHSHYCG--IISDKGRPRSRKIAESGRG-----KRYSYK 320
Query: 263 ISRARQVELLLVADASMARLYGR-GLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVL 321
+ + +E ++VAD +M +G + ++LT+ ++ L+ H S+ + L V+K+++L
Sbjct: 321 LPQEYNIETVVVADPAMVSYHGADAARRFILTILNMVFNLFQHKSLSVQVNLRVIKLILL 380
Query: 322 GDKDKSLEVSKNAATTLKNFCKWQHQH-NQLGDDHEE----------HYDAAILFTREDL 370
+ L + + L++FCKWQH+ + D H E DAAIL TR+D
Sbjct: 381 HETPPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMSTNWGEDMTSVDAAILITRKDF 440
Query: 371 CGHHS--CDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHD-DSKFCE 427
C H CDT+G+A + +CS +R C + ED+GL+ AFT+AHE+GH +G++HD D C
Sbjct: 441 CVHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTIAHEMGHNMGINHDNDHPSCA 500
Query: 428 ETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQI---LGPE 484
+ + + L + WS+C+ + FL NCLL + + + P
Sbjct: 501 DGLHIMSGEWIKGQNLGDVS----WSRCSKEDLERFLRSKASNCLLQTNPQSVNSVMVPS 556
Query: 485 ELPGQTYDATQQCNLTFGPEYSVCPGMD--VCARLWCAVVRQGQMVCLTKKLPAVEGTPC 542
+LPG TY A +QC + FGP S C M +C LWC V +G+ C TK P ++GT C
Sbjct: 557 KLPGMTYTADEQCQILFGPLASFCQEMQHVICTGLWCKV--EGEKECRTKLDPPMDGTDC 614
Query: 543 GKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNN 602
G+ C G+C +T + G W W CSR+C G+ R C P +
Sbjct: 615 DLGKWCKAGECTSRTSAPEHLA------GEWSLWSPCSRTCSAGISSRERKC--PGLDSE 666
Query: 603 GRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPA 662
R C G R YR C PCP FR QC+A Y K ++W P
Sbjct: 667 ARDCNGPRKQYRICENPPCPAGLPGFRDWQCQA---YSVRTSSPKHILQWQAVLDEEKP- 722
Query: 663 DVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCG 722
C L C G ++ S KV DGT C +C G+C + GCDG++GS + D CG
Sbjct: 723 --CALFCSPVGKEQPILLSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCG 780
Query: 723 VCGGDNSSCTKIVGTFN-KKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKN 781
VC G+ SC I G FN + GY +V+ IP GA IKV + K +YLAL+
Sbjct: 781 VCNGNGKSCKIIKGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPAH-----SYLALRDA- 834
Query: 782 GEYLINGKYMISTSETIIDINGTVMNY---SGWSHRDDFLHGMGYSATKEILIVQILATD 838
G+ IN + I S ++ GT ++Y W + + G T + ++ +L D
Sbjct: 835 GKQSINSDWKIEHSGA-FNLAGTTVHYVRRGLW----EKISAKG-PTTAPLHLLVLLFQD 888
Query: 839 PTKPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTR 898
L Y + +P P+ S + + +HTS W C TC G
Sbjct: 889 QNYGL--HYEYTIPSDPLPENQSSKAPEPLFMWTHTS--------WEDCDATCGGGERKT 938
Query: 899 TVQC 902
TV C
Sbjct: 939 TVSC 942
Score = 45.1 bits (105), Expect = 3e-04
Identities = 38/126 (30%), Positives = 48/126 (38%), Gaps = 25/126 (19%)
Query: 508 CPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYST--- 564
C G D C +W A V C K CGKG +C + KK ST
Sbjct: 1031 CEGQD-CMTVWEAGVWSE---CSVK---------CGKGIRHRTVRCTNPRKKCVLSTRPR 1077
Query: 565 -----SSHGNWGSW--GSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYC--TGKRAIYRS 615
+ W G W +CS +CG G+Q C + +G C + K A YR
Sbjct: 1078 EAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRP 1137
Query: 616 CSLMPC 621
C L PC
Sbjct: 1138 CHLQPC 1143
Score = 41.6 bits (96), Expect = 0.003
Identities = 18/53 (33%), Positives = 27/53 (50%), Gaps = 1/53 (1%)
Query: 879 WVTGPWLACSRTCDTGWHTRTVQCQDG-NRKLAKGCPLSQRPSAFKQCLLKKC 930
W G W CS TC G +R +QC + C S++P+A++ C L+ C
Sbjct: 1091 WRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPC 1143
Score = 37.0 bits (84), Expect = 0.085
Identities = 18/47 (38%), Positives = 22/47 (46%), Gaps = 4/47 (8%)
Query: 879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQC 925
W G W CS C G RTV+C + +K C LS RP + C
Sbjct: 1040 WEAGVWSECSVKCGKGIRHRTVRCTNPRKK----CVLSTRPREAEDC 1082
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 266 bits (680), Expect = 7e-71
Identities = 209/745 (28%), Positives = 318/745 (42%), Gaps = 69/745 (9%)
Query: 223 PAHSNPSGRAALASQLLDQ--SALSPAGGSGPQTWWRRRRRSISRAR----QVELLLVAD 276
P+H S AL Q + S +P G P ++R+R+ RA +ELL+
Sbjct: 30 PSHFQQSCLQALEPQAVSSYLSPGAPLKGRPPSPGFQRQRQRQRRAAGGILHLELLVAVG 89
Query: 277 ASMARLYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAAT 336
+ + + + Y+LT +I L S+ R+ +VK+V+L + + + ++ N +
Sbjct: 90 PDVFQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTS 149
Query: 337 TLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDL-CGHHSCDTLGMADVGTICSPERSCA 395
+L + C W N D H D + TR DL + G+ +G CSP SC
Sbjct: 150 SLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQVRGVTQLGGACSPTWSCL 209
Query: 396 VIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKC 455
+ ED G T+AHEIGH GL HD + G +M+S + A WS C
Sbjct: 210 ITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS----GCGPSGHVMASDGAAPRAGLAWSPC 265
Query: 456 TSATITEFLDDGHGNCLLDLPRKQILG----PEELPGQTYDATQQCNLTFGPEYSVCP-- 509
+ + L G C+ D PR Q P+ PG Y A +QC + FGP+ C
Sbjct: 266 SRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQPGLYYSANEQCRVAFGPKAVACTFA 325
Query: 510 --GMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSH 567
+D+C L C Q C +P ++GT CG + C +G+C + + + H
Sbjct: 326 REHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVELTPIA-AVH 384
Query: 568 GNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKS 627
G W SWG CSRSCGGGV R CNNP P GR C G C+ C
Sbjct: 385 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLE 444
Query: 628 FRHEQCEAKNGYQ-SDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTD 686
F +QC +G + G +F W +C+ CRA G + + D
Sbjct: 445 FMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLD 504
Query: 687 GTECRLY------SNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNK 740
GT C + S+CV G C GCDG + S+ +D+C VCGGDNS+C+ G+F
Sbjct: 505 GTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTA 564
Query: 741 -KSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETII 799
+++ Y + + T + + A + FT +LA+ + G Y++ GK IS + T
Sbjct: 565 GRAREYVTFLTVTPNLTSVYI----ANHRPLFT-HLAV-RIGGRYVVAGKMSISPNTTYP 618
Query: 800 DINGTVMNYSGWSHRDDFLHGMG----YSATKEILIVQILAT------DPTKPLDVRYSF 849
+ + +D L + + +E +Q+ + T+P D+ +++
Sbjct: 619 SLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRP-DITFTY 677
Query: 850 FVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRK- 908
F PK V + V GP CS +C G C D RK
Sbjct: 678 FQPKPRQAWVWAA-----------------VRGP---CSVSCGAGLRWVNYSCLDQARKE 717
Query: 909 --LAKGCPLSQRPSAFKQ-CLLKKC 930
C SQ+P A+ + C+L+ C
Sbjct: 718 LVETVQCQGSQQPPAWPEACVLEPC 742
Score = 33.5 bits (75), Expect = 0.94
Identities = 23/76 (30%), Positives = 30/76 (39%), Gaps = 8/76 (10%)
Query: 579 CSRSCGGGVQFAYRHCNNPAPRNNGR------YCTG--KRAIYRSCSLMPCPPNGKSFRH 630
CS SCG GV +C ++G C G + +CSL PCPP K
Sbjct: 962 CSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSL 1021
Query: 631 EQCEAKNGYQSDAKGV 646
C A G + + V
Sbjct: 1022 GPCSASCGLGTARRSV 1037
Score = 31.6 bits (70), Expect = 3.6
Identities = 46/212 (21%), Positives = 75/212 (35%), Gaps = 34/212 (16%)
Query: 457 SATITEFLDDGHGNCLLDLPRKQILGPEEL----PGQTYDATQQCNLTFGPEYSVCPGMD 512
+ T L+DG + L ++ EE+ P Q DA Q +G EY D
Sbjct: 614 NTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQE-DADIQVYRRYGEEYGNLTRPD 672
Query: 513 VCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYST-SSHGN-- 569
+ + RQ + + +V CG G + C+D+ +K+ T G+
Sbjct: 673 ITFTYFQPKPRQAWVWAAVRGPCSVS---CGAGLRWVNYSCLDQARKELVETVQCQGSQQ 729
Query: 570 ---------------WGSWGSWGQCSRSCGGGVQFAYRHC-------NNPAPRNNGRYCT 607
+ + G +G CS SCGGG++ C P R
Sbjct: 730 PPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGA 789
Query: 608 GKRAI-YRSCSLMPCPPNGKSFRHEQCEAKNG 638
+ A+ +C+ PCP + C + G
Sbjct: 790 QQPAVALETCNPQPCPARWEVSEPSSCTSAGG 821
Score = 30.8 bits (68), Expect = 6.1
Identities = 13/38 (34%), Positives = 17/38 (44%)
Query: 877 PQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCP 914
P W G + CS +C G R V+C + L K P
Sbjct: 744 PYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLP 781
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 266 bits (680), Expect = 7e-71
Identities = 209/745 (28%), Positives = 318/745 (42%), Gaps = 69/745 (9%)
Query: 223 PAHSNPSGRAALASQLLDQ--SALSPAGGSGPQTWWRRRRRSISRAR----QVELLLVAD 276
P+H S AL Q + S +P G P ++R+R+ RA +ELL+
Sbjct: 30 PSHFQQSCLQALEPQAVSSYLSPGAPLKGRPPSPGFQRQRQRQRRAAGGILHLELLVAVG 89
Query: 277 ASMARLYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAAT 336
+ + + + Y+LT +I L S+ R+ +VK+V+L + + + ++ N +
Sbjct: 90 PDVFQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTS 149
Query: 337 TLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDL-CGHHSCDTLGMADVGTICSPERSCA 395
+L + C W N D H D + TR DL + G+ +G CSP SC
Sbjct: 150 SLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQVRGVTQLGGACSPTWSCL 209
Query: 396 VIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKC 455
+ ED G T+AHEIGH GL HD + G +M+S + A WS C
Sbjct: 210 ITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS----GCGPSGHVMASDGAAPRAGLAWSPC 265
Query: 456 TSATITEFLDDGHGNCLLDLPRKQILG----PEELPGQTYDATQQCNLTFGPEYSVCP-- 509
+ + L G C+ D PR Q P+ PG Y A +QC + FGP+ C
Sbjct: 266 SRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQPGLYYSANEQCRVAFGPKAVACTFA 325
Query: 510 --GMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSH 567
+D+C L C Q C +P ++GT CG + C +G+C + + + H
Sbjct: 326 REHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVELTPIA-AVH 384
Query: 568 GNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKS 627
G W SWG CSRSCGGGV R CNNP P GR C G C+ C
Sbjct: 385 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLE 444
Query: 628 FRHEQCEAKNGYQ-SDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTD 686
F +QC +G + G +F W +C+ CRA G + + D
Sbjct: 445 FMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLD 504
Query: 687 GTECRLY------SNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNK 740
GT C + S+CV G C GCDG + S+ +D+C VCGGDNS+C+ G+F
Sbjct: 505 GTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTA 564
Query: 741 -KSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETII 799
+++ Y + + T + + A + FT +LA+ + G Y++ GK IS + T
Sbjct: 565 GRAREYVTFLTVTPNLTSVYI----ANHRPLFT-HLAV-RIGGRYVVAGKMSISPNTTYP 618
Query: 800 DINGTVMNYSGWSHRDDFLHGMG----YSATKEILIVQILAT------DPTKPLDVRYSF 849
+ + +D L + + +E +Q+ + T+P D+ +++
Sbjct: 619 SLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRP-DITFTY 677
Query: 850 FVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRK- 908
F PK V + V GP CS +C G C D RK
Sbjct: 678 FQPKPRQAWVWAA-----------------VRGP---CSVSCGAGLRWVNYSCLDQARKE 717
Query: 909 --LAKGCPLSQRPSAFKQ-CLLKKC 930
C SQ+P A+ + C+L+ C
Sbjct: 718 LVETVQCQGSQQPPAWPEACVLEPC 742
Score = 33.5 bits (75), Expect = 0.94
Identities = 23/76 (30%), Positives = 30/76 (39%), Gaps = 8/76 (10%)
Query: 579 CSRSCGGGVQFAYRHCNNPAPRNNGR------YCTG--KRAIYRSCSLMPCPPNGKSFRH 630
CS SCG GV +C ++G C G + +CSL PCPP K
Sbjct: 962 CSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSL 1021
Query: 631 EQCEAKNGYQSDAKGV 646
C A G + + V
Sbjct: 1022 GPCSASCGLGTARRSV 1037
Score = 31.6 bits (70), Expect = 3.6
Identities = 46/212 (21%), Positives = 75/212 (35%), Gaps = 34/212 (16%)
Query: 457 SATITEFLDDGHGNCLLDLPRKQILGPEEL----PGQTYDATQQCNLTFGPEYSVCPGMD 512
+ T L+DG + L ++ EE+ P Q DA Q +G EY D
Sbjct: 614 NTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQE-DADIQVYRRYGEEYGNLTRPD 672
Query: 513 VCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYST-SSHGN-- 569
+ + RQ + + +V CG G + C+D+ +K+ T G+
Sbjct: 673 ITFTYFQPKPRQAWVWAAVRGPCSVS---CGAGLRWVNYSCLDQARKELVETVQCQGSQQ 729
Query: 570 ---------------WGSWGSWGQCSRSCGGGVQFAYRHC-------NNPAPRNNGRYCT 607
+ + G +G CS SCGGG++ C P R
Sbjct: 730 PPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGA 789
Query: 608 GKRAI-YRSCSLMPCPPNGKSFRHEQCEAKNG 638
+ A+ +C+ PCP + C + G
Sbjct: 790 QQPAVALETCNPQPCPARWEVSEPSSCTSAGG 821
Score = 30.8 bits (68), Expect = 6.1
Identities = 13/38 (34%), Positives = 17/38 (44%)
Query: 877 PQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCP 914
P W G + CS +C G R V+C + L K P
Sbjct: 744 PYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLP 781
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 241 bits (614), Expect = 3e-63
Identities = 201/741 (27%), Positives = 309/741 (41%), Gaps = 92/741 (12%)
Query: 223 PAHSNPSGRAALASQLLDQ--SALSPAGGSGPQTWWRRRRRSISRAR----QVELLLVAD 276
P+H S AL Q + S +P G P ++R+R+ RA +ELL+
Sbjct: 30 PSHFQQSCLQALEPQAVSSYLSPGAPLKGRPPSPGFQRQRQRQRRAAGGILHLELLVAVG 89
Query: 277 ASMARLYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAAT 336
+ + + + Y+LT +I L S+ R+ +VK+V+L + + + ++ N +
Sbjct: 90 PDVFQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTS 149
Query: 337 TLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDL-CGHHSCDTLGMADVGTICSPERSCA 395
+L + C W N D H D + TR DL + G+ +G CSP SC
Sbjct: 150 SLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQVRGVTQLGGACSPTWSCL 209
Query: 396 VIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKC 455
+ ED G T+AHEIGH GL HD + G +M+S + A WS C
Sbjct: 210 ITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS----GCGPSGHVMASDGAAPRAGLAWSPC 265
Query: 456 TSATITEFLDDGHGNCLLDLPRKQILGPEELPGQTYDATQQCNLTFGPEYSVCP----GM 511
+ R+Q+L A +QC + FGP+ C +
Sbjct: 266 S--------------------RRQLLS-------LLSANEQCRVAFGPKAVACTFAREHL 298
Query: 512 DVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWG 571
D+C L C Q C +P ++GT CG + C +G+C + + + HG W
Sbjct: 299 DMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVELTPIA-AVHGRWS 357
Query: 572 SWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHE 631
SWG CSRSCGGGV R CNNP P GR C G C+ C F +
Sbjct: 358 SWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQ 417
Query: 632 QCEAKNGYQ-SDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTEC 690
QC +G + G +F W +C+ CRA G + + DGT C
Sbjct: 418 QCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRC 477
Query: 691 RLY------SNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNK-KSK 743
+ S+CV G C GCDG + S+ +D+C VCGGDNS+C+ G+F +++
Sbjct: 478 MPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAR 537
Query: 744 GYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDING 803
Y + + T + + A + FT +LA+ + G Y++ GK IS + T +
Sbjct: 538 EYVTFLTVTPNLTSVYI----ANHRPLFT-HLAV-RIGGRYVVAGKMSISPNTTYPSLLE 591
Query: 804 TVMNYSGWSHRDDFLHGMG----YSATKEILIVQILAT------DPTKPLDVRYSFFVPK 853
+ +D L + + +E +Q+ + T+P D+ +++F PK
Sbjct: 592 DGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRP-DITFTYFQPK 650
Query: 854 KSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRK---LA 910
V + V GP CS +C G C D RK
Sbjct: 651 PRQAWVWAA-----------------VRGP---CSVSCGAGLRWVNYSCLDQARKELVET 690
Query: 911 KGCPLSQRPSAFKQ-CLLKKC 930
C SQ+P A+ + C+L+ C
Sbjct: 691 VQCQGSQQPPAWPEACVLEPC 711
Score = 33.5 bits (75), Expect = 0.94
Identities = 23/76 (30%), Positives = 30/76 (39%), Gaps = 8/76 (10%)
Query: 579 CSRSCGGGVQFAYRHCNNPAPRNNGR------YCTG--KRAIYRSCSLMPCPPNGKSFRH 630
CS SCG GV +C ++G C G + +CSL PCPP K
Sbjct: 931 CSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSL 990
Query: 631 EQCEAKNGYQSDAKGV 646
C A G + + V
Sbjct: 991 GPCSASCGLGTARRSV 1006
Score = 31.6 bits (70), Expect = 3.6
Identities = 46/212 (21%), Positives = 75/212 (35%), Gaps = 34/212 (16%)
Query: 457 SATITEFLDDGHGNCLLDLPRKQILGPEEL----PGQTYDATQQCNLTFGPEYSVCPGMD 512
+ T L+DG + L ++ EE+ P Q DA Q +G EY D
Sbjct: 583 NTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQE-DADIQVYRRYGEEYGNLTRPD 641
Query: 513 VCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYST-SSHGN-- 569
+ + RQ + + +V CG G + C+D+ +K+ T G+
Sbjct: 642 ITFTYFQPKPRQAWVWAAVRGPCSVS---CGAGLRWVNYSCLDQARKELVETVQCQGSQQ 698
Query: 570 ---------------WGSWGSWGQCSRSCGGGVQFAYRHC-------NNPAPRNNGRYCT 607
+ + G +G CS SCGGG++ C P R
Sbjct: 699 PPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGA 758
Query: 608 GKRAI-YRSCSLMPCPPNGKSFRHEQCEAKNG 638
+ A+ +C+ PCP + C + G
Sbjct: 759 QQPAVALETCNPQPCPARWEVSEPSSCTSAGG 790
Score = 30.8 bits (68), Expect = 6.1
Identities = 13/38 (34%), Positives = 17/38 (44%)
Query: 877 PQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCP 914
P W G + CS +C G R V+C + L K P
Sbjct: 713 PYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLP 750
>gi|11038659 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 2 [Homo sapiens]
Length = 566
Score = 166 bits (421), Expect = 7e-41
Identities = 132/433 (30%), Positives = 199/433 (45%), Gaps = 60/433 (13%)
Query: 130 CFYRGTVDGSPRSLAV-FDLCGGLDGFFAVKHARYTLKPLLRGPWAEE-EKGRVYGDGSA 187
C Y G V G + +V C GL G ++ + ++PL +G A+E E+GRV+
Sbjct: 155 CLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQGRVHV---- 210
Query: 188 RILHVYTREGFSF-----EALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLDQS 242
VY R S +AL AS ++ S A H+N S R
Sbjct: 211 ----VYRRPPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEHANSSRR----------- 255
Query: 243 ALSPAGGSGPQTWWRRRRRSISRARQVELLLVADASMARLYGRG-LQHYLLTLASIANRL 301
R RR + +E+LL D S+ + +G+ +Q YLLTL +I N +
Sbjct: 256 --------------RARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEI 301
Query: 302 YSHASIENHIRLAVVKVVVLG-DKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYD 360
Y S+ HI + +V++++L K SL N + +L+N C+W + + H+E++D
Sbjct: 302 YHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHD 361
Query: 361 AAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSH 420
AI TR+D G A V +C P RSC + +DG +AF VAHE GH+LG+ H
Sbjct: 362 HAIFLTRQDF---GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEH 418
Query: 421 D-DSKFC--EETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLP- 476
D C E GS +M+ ++ + WS+C+ ++ +L +CLLD P
Sbjct: 419 DGQGNRCGDEVRLGS-----IMAPLVQAAFHRFHWSRCSQQELSRYLHS--YDCLLDDPF 471
Query: 477 RKQILGPEELPGQTYDATQQCNLTFGPEYSVCPG---MDVCARLWCAVVRQGQMVCLTKK 533
+LPG Y +QC FG Y +C D C +LWC+ C TKK
Sbjct: 472 AHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCS-HPDNPYFCKTKK 530
Query: 534 LPAVEGTPCGKGR 546
P ++GT C G+
Sbjct: 531 GPPLDGTMCAPGK 543
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 162 bits (410), Expect = 1e-39
Identities = 117/427 (27%), Positives = 173/427 (40%), Gaps = 87/427 (20%)
Query: 568 GNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKS 627
GNW +WG W CSR+CGGG ++ R C GR C G+ Y++CS CPP+ +
Sbjct: 76 GNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPPDAED 129
Query: 628 FRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDG 687
FR +QC A N Q + EW+P+Y PA C L C A+G V +PKV DG
Sbjct: 130 FRAQQCSAYNDVQYQGH----YYEWLPRYND--PAAPCALKCHAQGQNLVVELAPKVLDG 183
Query: 688 TECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVG---TFNKKSKG 744
T C S +C+ G C GCD +GS + D CGVC GD S+C + G + K
Sbjct: 184 TRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKR 243
Query: 745 YTDVVRIPEGATHIKVRQFKAKDQTR-FTAYLALKKKNGEYLINGKYMISTSETIIDING 803
+V+ +P G+ +++ K F L+ GE+ N S + +
Sbjct: 244 EENVIAVPLGSRSVRI---TVKGPAHLFIESKTLQGSKGEHSFN-------SPGVFLVEN 293
Query: 804 TVMNYSGWSHRD----------DFLHGMGYSATKEILIVQILATDP-------------- 839
T + + S R DF+ Y+A K+ +VQ P
Sbjct: 294 TTVEFQRGSERQTFKIPGPLMADFIFKTRYTAAKD-SVVQFFFYQPISHQWRQTDFFPCT 352
Query: 840 -----------TKPLDVRYSFFVPK----------KSTPKVNSV------TSHGSNKVGS 872
+ +D+R VP K PK+ +S G ++
Sbjct: 353 VTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMP 412
Query: 873 H---TSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGN------RKLAKGCPLSQRPSAFK 923
+ P+W PW ACS +C G R+ C + + + C + +P +
Sbjct: 413 YDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQ 472
Query: 924 QCLLKKC 930
C L C
Sbjct: 473 TCNLFDC 479
Score = 40.0 bits (92), Expect = 0.010
Identities = 23/69 (33%), Positives = 30/69 (43%), Gaps = 6/69 (8%)
Query: 574 GSWGQCSRSCGGGVQFAYRHC----NNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFR 629
GSWG CS +CG G+Q +C PAP R K ++C+ CPP
Sbjct: 710 GSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECR--DEKPHALQACNQFDCPPGWHIEE 767
Query: 630 HEQCEAKNG 638
+QC G
Sbjct: 768 WQQCSRTCG 776
Score = 38.1 bits (87), Expect = 0.038
Identities = 16/55 (29%), Positives = 26/55 (47%), Gaps = 3/55 (5%)
Query: 879 WVTGPWLACSRTCDTGWHTRTVQC---QDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
W TGPW C+ C G+ +R V C + + C ++P +++ CL C
Sbjct: 1601 WHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSC 1655
Score = 36.2 bits (82), Expect = 0.15
Identities = 19/55 (34%), Positives = 26/55 (47%), Gaps = 6/55 (10%)
Query: 576 WGQCSRSCGGGVQFAYRHCNNPAPRN-----NGRYCTG-KRAIYRSCSLMPCPPN 624
W QCSR+CGGG Q C + C G K + ++SC+ CPP+
Sbjct: 768 WQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPH 822
Score = 36.2 bits (82), Expect = 0.15
Identities = 18/59 (30%), Positives = 27/59 (45%), Gaps = 6/59 (10%)
Query: 878 QWVTGPWLACSRTCDTGWHTRTVQCQ----DGNRKLA--KGCPLSQRPSAFKQCLLKKC 930
+W T W CS +C G+H+R V C+ +G ++ + C RP K C C
Sbjct: 1486 RWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPC 1544
Score = 35.4 bits (80), Expect = 0.25
Identities = 13/30 (43%), Positives = 18/30 (60%)
Query: 874 TSQPQWVTGPWLACSRTCDTGWHTRTVQCQ 903
T +P ++ PW ACS TC G R V+C+
Sbjct: 563 TEEPTFIPEPWSACSTTCGPGVQVREVKCR 592
Score = 33.9 bits (76), Expect = 0.72
Identities = 13/26 (50%), Positives = 14/26 (53%)
Query: 877 PQWVTGPWLACSRTCDTGWHTRTVQC 902
P+W G W CS TC G TR V C
Sbjct: 705 PRWHVGSWGPCSATCGVGIQTRDVYC 730
Score = 31.6 bits (70), Expect = 3.6
Identities = 13/51 (25%), Positives = 23/51 (45%)
Query: 877 PQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLL 927
P+W+ W C+ TC G R V C + + GC + ++C++
Sbjct: 480 PKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVI 530
Score = 31.2 bits (69), Expect = 4.7
Identities = 19/59 (32%), Positives = 24/59 (40%), Gaps = 5/59 (8%)
Query: 877 PQWVTGPWLACSRTCDTGWHTRTVQCQ----DGN-RKLAKGCPLSQRPSAFKQCLLKKC 930
P W W CSRTC G R V C+ DG+ L+ + S+ K C C
Sbjct: 761 PGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDC 819
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 162 bits (409), Expect = 2e-39
Identities = 119/413 (28%), Positives = 169/413 (40%), Gaps = 96/413 (23%)
Query: 570 WGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFR 629
WG W W CSR+CGGGV F R C + R+ G C G +RSC CP + FR
Sbjct: 29 WGPWSQWSPCSRTCGGGVSFRERPCYSQR-RDGGSSCVGPARSHRSCRTESCPDGARDFR 87
Query: 630 HEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTE 689
EQC +G + + + W+P Y+ + C+L C KG +Y V DGT
Sbjct: 88 AEQCAEFDGAEFQGRRYR----WLPYYSA---PNKCELNCIPKGENFYYKHREAVVDGTP 140
Query: 690 CRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKKSKGYTDVV 749
C VCV G C GCD + S Q DKC CGGD ++C + GTF+
Sbjct: 141 CEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFD---------- 190
Query: 750 RIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDINGTVMNYS 809
A D +R A+K GEY +NG + I + + T+++Y
Sbjct: 191 ---------------ANDLSR-----AVKNVRGEYYLNGHWTIEAARA-LPAASTILHYE 229
Query: 810 GWSHRD---DFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVPKKSTPKVNSVTSHG 866
+ D + LH G T E L++++++ +P V Y + +P + P SHG
Sbjct: 230 RGAEGDLAPERLHARG--PTSEPLVIELISQEPNP--GVHYEYHLPLR-RPSPGFSWSHG 284
Query: 867 S------NKVGSHTS-------------------QP-----------------QWVTGPW 884
S G H S QP +W GPW
Sbjct: 285 SWSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPCPETKRWKAGPW 344
Query: 885 LACSRTCDTGWHTRTVQC--QDGNR-----KLAKGCPLSQRPSAFKQCLLKKC 930
CS +C G +R+V C DG + A+ L +P A + C L++C
Sbjct: 345 APCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC 397
Score = 35.4 bits (80), Expect = 0.25
Identities = 17/54 (31%), Positives = 24/54 (44%), Gaps = 2/54 (3%)
Query: 879 WVTGPWLACSRTCDTGWHTRTVQC--QDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
W PW CS +C G R+V C + G+ C L RP + C+ + C
Sbjct: 400 WSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDC 453
Score = 34.3 bits (77), Expect = 0.55
Identities = 36/138 (26%), Positives = 52/138 (37%), Gaps = 10/138 (7%)
Query: 486 LPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAV-VRQGQMVCLTKKLPAVEGTPCG- 543
LPG+ A Q CNL +S P + C V VR+ + C ++ + C
Sbjct: 382 LPGKP-PAIQACNLQRCAAWSPEPWGECSVS--CGVGVRKRSVTCRGERGSLLHTAACSL 438
Query: 544 KGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNG 603
+ R L CV + + H G+WG CS+SC G + C P + G
Sbjct: 439 EDRPPLTEPCVHEDCPLLSDQAWHV-----GTWGLCSKSCSSGTRRRQVICAIGPPSHCG 493
Query: 604 RYCTGKRAIYRSCSLMPC 621
K C+ PC
Sbjct: 494 SLQHSKPVDVEPCNTQPC 511
>gi|226442878 ADAMTS-like 5 [Homo sapiens]
Length = 471
Score = 159 bits (401), Expect = 1e-38
Identities = 100/294 (34%), Positives = 140/294 (47%), Gaps = 23/294 (7%)
Query: 563 STSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCP 622
S G W W SW +CS SCG GV R C C G YR C L CP
Sbjct: 31 SAQGPGEWTPWVSWTRCSSSCGRGVSVRSRRCLRLPGEEP---CWGDSHEYRLCQLPDCP 87
Query: 623 PNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSP 682
P FR QC NG G + +WVP + + C L C A+G +Y F
Sbjct: 88 PGAVPFRDLQCALYNG--RPVLGTQKTYQWVPFHGA---PNQCDLNCLAEGHAFYHSFG- 141
Query: 683 KVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKKS 742
+V DGT C + VCV G+C+ GCDG++GS D+CG CGG N SC + F
Sbjct: 142 RVLDGTACSPGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAG 201
Query: 743 --KGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIID 800
GY +V IPEGA HI+V + R +LAL +G Y++NG +++S T +
Sbjct: 202 AFAGYWNVTLIPEGARHIRV-------EHRSRNHLALMGGDGRYVLNGHWVVSPPGT-YE 253
Query: 801 INGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVPKK 854
GT + Y+ + + L G T L++Q+L +P + + F++P++
Sbjct: 254 AAGTHVVYTRDTGPQETLQAAG--PTSHDLLLQVLLQEPNP--GIEFEFWLPRE 303
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 159 bits (401), Expect = 1e-38
Identities = 112/348 (32%), Positives = 158/348 (45%), Gaps = 52/348 (14%)
Query: 568 GNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKS 627
G W +WG W +CSR+CGGG ++ R C + + C G+ YR+CS + CPP
Sbjct: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPPEAGD 87
Query: 628 FRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDG 687
FR +QC A N D K F EW+P P + C L C+AKGT V +PKV DG
Sbjct: 88 FRAQQCSAHN----DVKHHGQFYEWLPVSND--PDNPCSLKCQAKGTTLVVELAPKVLDG 141
Query: 688 TECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKK---SKG 744
T C S +C+ G C GCD +GS ++ D CGVC GD S+C + G + + +K
Sbjct: 142 TRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKS 201
Query: 745 YTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDINGT 804
VV IP G+ HI++ K D YL K G G+ +S++ T + N +
Sbjct: 202 DDTVVAIPYGSRHIRL-VLKGPDH----LYLETKTLQG---TKGENSLSSTGTFLVDNSS 253
Query: 805 VMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVPKKSTPKVNSVTS 864
V DF KEIL + PL F V +++ +S
Sbjct: 254 V----------DFQK----FPDKEILRM-------AGPLTA--DFIVKIRNSGSADSTVQ 290
Query: 865 HGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQD--GNRKLA 910
+ H +W + CS TC G+ + +C D NR +A
Sbjct: 291 FIFYQPIIH----RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVA 334
Score = 40.0 bits (92), Expect = 0.010
Identities = 33/116 (28%), Positives = 41/116 (35%), Gaps = 15/116 (12%)
Query: 538 EGTPCGKGRICLQGKCV--------DKTKKKYYSTSSHGNWGSWGSWG--QCSRSCGGGV 587
EG R C G C D+T + W G +CS SCGGGV
Sbjct: 568 EGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGV 627
Query: 588 QFAYRHCNNPAPRN--NGRYCTGKR---AIYRSCSLMPCPPNGKSFRHEQCEAKNG 638
Q A C N R C R + +SC+L PCP + + C G
Sbjct: 628 QEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCG 683
Score = 37.0 bits (84), Expect = 0.085
Identities = 15/51 (29%), Positives = 23/51 (45%)
Query: 877 PQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLL 927
P+W+ W C+ TC G R V C D GC +P ++C++
Sbjct: 438 PKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECIV 488
Score = 34.3 bits (77), Expect = 0.55
Identities = 12/26 (46%), Positives = 15/26 (57%)
Query: 877 PQWVTGPWLACSRTCDTGWHTRTVQC 902
P+W PW ACS +C G +R V C
Sbjct: 378 PRWEATPWTACSSSCGGGIQSRAVSC 403
Score = 33.1 bits (74), Expect = 1.2
Identities = 18/63 (28%), Positives = 26/63 (41%), Gaps = 14/63 (22%)
Query: 878 QWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKG----------CPLSQRPSAFKQCLL 927
+W+ W CS +C G TR+ C RK+ K CP S+ + C+L
Sbjct: 791 EWLLSDWTECSTSCGEGTQTRSAIC----RKMLKTGLSTVVNSTLCPPLPFSSSIRPCML 846
Query: 928 KKC 930
C
Sbjct: 847 ATC 849
Score = 33.1 bits (74), Expect = 1.2
Identities = 12/26 (46%), Positives = 16/26 (61%)
Query: 878 QWVTGPWLACSRTCDTGWHTRTVQCQ 903
+W+ W AC+R+C G TR V CQ
Sbjct: 1548 RWMVTSWSACTRSCGGGVQTRRVTCQ 1573
Score = 31.6 bits (70), Expect = 3.6
Identities = 11/30 (36%), Positives = 17/30 (56%)
Query: 874 TSQPQWVTGPWLACSRTCDTGWHTRTVQCQ 903
+ +P ++ W AC+ TC G R V+CQ
Sbjct: 521 SEEPSFIPEAWSACTVTCGVGTQVRIVRCQ 550
Score = 31.2 bits (69), Expect = 4.7
Identities = 38/180 (21%), Positives = 63/180 (35%), Gaps = 25/180 (13%)
Query: 469 GNCLLDLPRKQILGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMV 528
G C ++P P+E G + Q + + EY G C+ V++ +
Sbjct: 581 GPCSGEIPE---FNPDETDG-LFGGLQDFDELYDWEYE---GFTKCSESCGGGVQEAVVS 633
Query: 529 CLTKKL--PAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGG 586
CL K+ PA E +C+ + + K W G W CS +CG G
Sbjct: 634 CLNKQTREPAEEN-------LCVTSRRPPQLLKSCNLDPCPARW-EIGKWSPCSLTCGVG 685
Query: 587 VQFAYRHCNNPAPRNNGRYC--------TGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNG 638
+Q C++ R K + ++C+ CPP + + C G
Sbjct: 686 LQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCG 745
Score = 31.2 bits (69), Expect = 4.7
Identities = 12/25 (48%), Positives = 13/25 (52%)
Query: 878 QWVTGPWLACSRTCDTGWHTRTVQC 902
+W G W CS TC G TR V C
Sbjct: 669 RWEIGKWSPCSLTCGVGLQTRDVFC 693
Score = 31.2 bits (69), Expect = 4.7
Identities = 12/27 (44%), Positives = 13/27 (48%)
Query: 877 PQWVTGPWLACSRTCDTGWHTRTVQCQ 903
P W W CSRTC G R V C+
Sbjct: 730 PAWYPAQWQPCSRTCGGGVQKREVLCK 756
Score = 31.2 bits (69), Expect = 4.7
Identities = 11/14 (78%), Positives = 12/14 (85%)
Query: 575 SWGQCSRSCGGGVQ 588
SW C+RSCGGGVQ
Sbjct: 1553 SWSACTRSCGGGVQ 1566
>gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]
Length = 525
Score = 159 bits (401), Expect = 1e-38
Identities = 112/348 (32%), Positives = 158/348 (45%), Gaps = 52/348 (14%)
Query: 568 GNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKS 627
G W +WG W +CSR+CGGG ++ R C + + C G+ YR+CS + CPP
Sbjct: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPPEAGD 87
Query: 628 FRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDG 687
FR +QC A N D K F EW+P P + C L C+AKGT V +PKV DG
Sbjct: 88 FRAQQCSAHN----DVKHHGQFYEWLPVSND--PDNPCSLKCQAKGTTLVVELAPKVLDG 141
Query: 688 TECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKK---SKG 744
T C S +C+ G C GCD +GS ++ D CGVC GD S+C + G + + +K
Sbjct: 142 TRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKS 201
Query: 745 YTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDINGT 804
VV IP G+ HI++ K D YL K G G+ +S++ T + N +
Sbjct: 202 DDTVVAIPYGSRHIRL-VLKGPDH----LYLETKTLQG---TKGENSLSSTGTFLVDNSS 253
Query: 805 VMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVPKKSTPKVNSVTS 864
V DF KEIL + PL F V +++ +S
Sbjct: 254 V----------DFQK----FPDKEILRM-------AGPLTA--DFIVKIRNSGSADSTVQ 290
Query: 865 HGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQD--GNRKLA 910
+ H +W + CS TC G+ + +C D NR +A
Sbjct: 291 FIFYQPIIH----RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVA 334
Score = 37.0 bits (84), Expect = 0.085
Identities = 15/51 (29%), Positives = 23/51 (45%)
Query: 877 PQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLL 927
P+W+ W C+ TC G R V C D GC +P ++C++
Sbjct: 438 PKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECIV 488
Score = 34.3 bits (77), Expect = 0.55
Identities = 12/26 (46%), Positives = 15/26 (57%)
Query: 877 PQWVTGPWLACSRTCDTGWHTRTVQC 902
P+W PW ACS +C G +R V C
Sbjct: 378 PRWEATPWTACSSSCGGGIQSRAVSC 403
>gi|223718260 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 156 bits (395), Expect = 7e-38
Identities = 93/249 (37%), Positives = 123/249 (49%), Gaps = 22/249 (8%)
Query: 570 WGSWGSWGQCSRSCGGGVQFAYRHC----NNPAPRNNGRYCTGKRAIYRSCSLMPCPPNG 625
WG W W CSRSCGGGV RHC P R CTG Y+ C + CPP+G
Sbjct: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
Query: 626 KSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGV---LPADVCKLTCRAKGTGYYVVFSP 682
+SFR EQC + N + + + +W P Y + + C L C G + P
Sbjct: 110 RSFREEQCVSFNSHVYNGRTH----QWKPLYPDDYVHISSKPCDLHCTTVD-GQRQLMVP 164
Query: 683 KVTDGTECRLYS-NSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKK 741
DGT C+L VCV GKC GCDG++ S DKCG+C GD SSCT + G + K
Sbjct: 165 -ARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKG 223
Query: 742 SK--GYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETII 799
+ GY+ V IP GA I++ + K + LAL + G Y NG Y + + +
Sbjct: 224 NAHLGYSLVTHIPAGARDIQIVERK-----KSADVLALADEAGYYFFNGNYKVDSPKN-F 277
Query: 800 DINGTVMNY 808
+I GTV+ Y
Sbjct: 278 NIAGTVVKY 286
Score = 43.5 bits (101), Expect = 0.001
Identities = 18/53 (33%), Positives = 27/53 (50%), Gaps = 1/53 (1%)
Query: 878 QWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
+W T PW C++TC G R V+C G + +GC +P + C L+ C
Sbjct: 856 KWYTSPWSECTKTCGVGVRMRDVKCYQGT-DIVRGCDPLVKPVGRQACDLQPC 907
Score = 38.9 bits (89), Expect = 0.022
Identities = 14/27 (51%), Positives = 17/27 (62%)
Query: 876 QPQWVTGPWLACSRTCDTGWHTRTVQC 902
QP+W T W CSRTC G+ R V+C
Sbjct: 623 QPRWETSSWSECSRTCGEGYQFRVVRC 649
Score = 34.3 bits (77), Expect = 0.55
Identities = 18/55 (32%), Positives = 22/55 (40%), Gaps = 2/55 (3%)
Query: 878 QWVTGPWLACSRTCDTGWHTRTVQCQ--DGNRKLAKGCPLSQRPSAFKQCLLKKC 930
QW W CS +C G R V C+ DG C + +P A C K C
Sbjct: 740 QWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNC 794
Score = 33.5 bits (75), Expect = 0.94
Identities = 22/76 (28%), Positives = 33/76 (43%), Gaps = 9/76 (11%)
Query: 575 SWGQCSRSCGGGVQFAYRHC---NNPAPRNN--GRYCTGKRAI----YRSCSLMPCPPNG 625
SW +CSR+CG G QF C +P ++ C A+ ++C C P
Sbjct: 630 SWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQW 689
Query: 626 KSFRHEQCEAKNGYQS 641
+ +C AK G +S
Sbjct: 690 EMSEWSECTAKCGERS 705
Score = 32.0 bits (71), Expect = 2.7
Identities = 17/65 (26%), Positives = 25/65 (38%), Gaps = 5/65 (7%)
Query: 871 GSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQD---GNRKLAKG--CPLSQRPSAFKQC 925
G W+ W C+ TC G R V C + G + G C L+++P C
Sbjct: 790 GDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTC 849
Query: 926 LLKKC 930
+ C
Sbjct: 850 FERPC 854
Score = 30.4 bits (67), Expect = 8.0
Identities = 14/47 (29%), Positives = 21/47 (44%)
Query: 576 WGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCP 622
W +C+++CG GV+ C G K ++C L PCP
Sbjct: 862 WSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCP 908
>gi|41281450 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 156 bits (395), Expect = 7e-38
Identities = 93/249 (37%), Positives = 123/249 (49%), Gaps = 22/249 (8%)
Query: 570 WGSWGSWGQCSRSCGGGVQFAYRHC----NNPAPRNNGRYCTGKRAIYRSCSLMPCPPNG 625
WG W W CSRSCGGGV RHC P R CTG Y+ C + CPP+G
Sbjct: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
Query: 626 KSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGV---LPADVCKLTCRAKGTGYYVVFSP 682
+SFR EQC + N + + + +W P Y + + C L C G + P
Sbjct: 110 RSFREEQCVSFNSHVYNGRTH----QWKPLYPDDYVHISSKPCDLHCTTVD-GQRQLMVP 164
Query: 683 KVTDGTECRLYS-NSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKK 741
DGT C+L VCV GKC GCDG++ S DKCG+C GD SSCT + G + K
Sbjct: 165 -ARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKG 223
Query: 742 SK--GYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETII 799
+ GY+ V IP GA I++ + K + LAL + G Y NG Y + + +
Sbjct: 224 NAHLGYSLVTHIPAGARDIQIVERK-----KSADVLALADEAGYYFFNGNYKVDSPKN-F 277
Query: 800 DINGTVMNY 808
+I GTV+ Y
Sbjct: 278 NIAGTVVKY 286
Score = 43.5 bits (101), Expect = 0.001
Identities = 18/53 (33%), Positives = 27/53 (50%), Gaps = 1/53 (1%)
Query: 878 QWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
+W T PW C++TC G R V+C G + +GC +P + C L+ C
Sbjct: 856 KWYTSPWSECTKTCGVGVRMRDVKCYQGT-DIVRGCDPLVKPVGRQACDLQPC 907
Score = 38.9 bits (89), Expect = 0.022
Identities = 14/27 (51%), Positives = 17/27 (62%)
Query: 876 QPQWVTGPWLACSRTCDTGWHTRTVQC 902
QP+W T W CSRTC G+ R V+C
Sbjct: 623 QPRWETSSWSECSRTCGEGYQFRVVRC 649
Score = 34.3 bits (77), Expect = 0.55
Identities = 18/55 (32%), Positives = 22/55 (40%), Gaps = 2/55 (3%)
Query: 878 QWVTGPWLACSRTCDTGWHTRTVQCQ--DGNRKLAKGCPLSQRPSAFKQCLLKKC 930
QW W CS +C G R V C+ DG C + +P A C K C
Sbjct: 740 QWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNC 794
Score = 33.5 bits (75), Expect = 0.94
Identities = 22/76 (28%), Positives = 33/76 (43%), Gaps = 9/76 (11%)
Query: 575 SWGQCSRSCGGGVQFAYRHC---NNPAPRNN--GRYCTGKRAI----YRSCSLMPCPPNG 625
SW +CSR+CG G QF C +P ++ C A+ ++C C P
Sbjct: 630 SWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQW 689
Query: 626 KSFRHEQCEAKNGYQS 641
+ +C AK G +S
Sbjct: 690 EMSEWSECTAKCGERS 705
Score = 32.0 bits (71), Expect = 2.7
Identities = 17/65 (26%), Positives = 25/65 (38%), Gaps = 5/65 (7%)
Query: 871 GSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQD---GNRKLAKG--CPLSQRPSAFKQC 925
G W+ W C+ TC G R V C + G + G C L+++P C
Sbjct: 790 GDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTC 849
Query: 926 LLKKC 930
+ C
Sbjct: 850 FERPC 854
Score = 30.4 bits (67), Expect = 8.0
Identities = 14/47 (29%), Positives = 21/47 (44%)
Query: 576 WGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCP 622
W +C+++CG GV+ C G K ++C L PCP
Sbjct: 862 WSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCP 908
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.432
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,413,030
Number of Sequences: 37866
Number of extensions: 2191885
Number of successful extensions: 7853
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 98
Number of HSP's successfully gapped in prelim test: 55
Number of HSP's that attempted gapping in prelim test: 6781
Number of HSP's gapped (non-prelim): 750
length of query: 930
length of database: 18,247,518
effective HSP length: 112
effective length of query: 818
effective length of database: 14,006,526
effective search space: 11457338268
effective search space used: 11457338268
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.