Search of human proteins with 194239662

Search of human proteins with 194239662

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|194239662 SHC (Src homology 2 domain containing)
transforming protein 1 isoform 1 [Homo sapiens]
         (583 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|194239662 SHC (Src homology 2 domain containing) transforming...  1201   0.0  
gi|194239664 SHC (Src homology 2 domain containing) transforming...  1196   0.0  
gi|194239668 SHC (Src homology 2 domain containing) transforming...   976   0.0  
gi|32261324 SHC (Src homology 2 domain containing) transforming ...   972   0.0  
gi|169790811 SHC (Src homology 2 domain containing) transforming...   505   e-143
gi|224586793 src homology 2 domain-containing transforming prote...   500   e-141
gi|222446609 rai-like protein [Homo sapiens]                          473   e-133
gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo ...   164   2e-40
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]      67   5e-11
gi|208609985 SH2 domain containing 3A [Homo sapiens]                   64   4e-10
gi|224926824 SH2B adaptor protein 1 isoform 2 [Homo sapiens]           63   9e-10
gi|224926830 SH2B adaptor protein 1 isoform 3 [Homo sapiens]           63   9e-10
gi|224926828 SH2B adaptor protein 1 isoform 2 [Homo sapiens]           63   9e-10
gi|224926826 SH2B adaptor protein 1 isoform 1 [Homo sapiens]           63   9e-10
gi|224926822 SH2B adaptor protein 1 isoform 2 [Homo sapiens]           63   9e-10
gi|7705318 GULP, engulfment adaptor PTB domain containing 1 [Hom...    61   2e-09
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]          60   6e-09
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]            60   6e-09
gi|41281821 SH2 domain containing 3C isoform a [Homo sapiens]          60   6e-09
gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens]      60   7e-09
gi|4885455 SH2B adaptor protein 3 [Homo sapiens]                       59   9e-09
gi|242247193 SH2B adaptor protein 2 [Homo sapiens]                     58   3e-08
gi|216547763 SH2 domain containing 3C isoform b [Homo sapiens]         57   4e-08
gi|216547801 SH2 domain containing 3C isoform e [Homo sapiens]         57   5e-08
gi|216547790 SH2 domain containing 3C isoform d [Homo sapiens]         57   5e-08
gi|222537752 Src homology 2 domain containing transforming prote...    56   1e-07
gi|117320537 phospholipase C, gamma 2 [Homo sapiens]                   53   7e-07
gi|5453754 NCK adaptor protein 1 [Homo sapiens]                        53   7e-07
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]              53   9e-07
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]                53   9e-07

>gi|194239662 SHC (Src homology 2 domain containing) transforming
           protein 1 isoform 1 [Homo sapiens]
          Length = 583

 Score = 1201 bits (3106), Expect = 0.0
 Identities = 583/583 (100%), Positives = 583/583 (100%)

Query: 1   MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS 60
           MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS
Sbjct: 1   MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS 60

Query: 61  FFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGR 120
           FFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGR
Sbjct: 61  FFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGR 120

Query: 121 RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD 180
           RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD
Sbjct: 121 RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD 180

Query: 181 FNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS 240
           FNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS
Sbjct: 181 FNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS 240

Query: 241 LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV 300
           LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV
Sbjct: 241 LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV 300

Query: 301 ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL 360
           ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL
Sbjct: 301 ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL 360

Query: 361 GGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPGRE 420
           GGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPGRE
Sbjct: 361 GGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPGRE 420

Query: 421 LFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVPPPPQSVSMA 480
           LFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVPPPPQSVSMA
Sbjct: 421 LFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVPPPPQSVSMA 480

Query: 481 EQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEG 540
           EQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEG
Sbjct: 481 EQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEG 540

Query: 541 VVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL 583
           VVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL
Sbjct: 541 VVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL 583


>gi|194239664 SHC (Src homology 2 domain containing) transforming
           protein 1 isoform 3 [Homo sapiens]
          Length = 584

 Score = 1196 bits (3094), Expect = 0.0
 Identities = 583/584 (99%), Positives = 583/584 (99%), Gaps = 1/584 (0%)

Query: 1   MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS 60
           MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS
Sbjct: 1   MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS 60

Query: 61  FFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGR 120
           FFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGR
Sbjct: 61  FFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGR 120

Query: 121 RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD 180
           RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD
Sbjct: 121 RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD 180

Query: 181 FNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS 240
           FNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS
Sbjct: 181 FNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS 240

Query: 241 LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV 300
           LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV
Sbjct: 241 LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV 300

Query: 301 ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL 360
           ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL
Sbjct: 301 ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL 360

Query: 361 GGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCP-GR 419
           GGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCP GR
Sbjct: 361 GGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPAGR 420

Query: 420 ELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVPPPPQSVSM 479
           ELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVPPPPQSVSM
Sbjct: 421 ELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVPPPPQSVSM 480

Query: 480 AEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPE 539
           AEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPE
Sbjct: 481 AEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPE 540

Query: 540 GVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL 583
           GVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL
Sbjct: 541 GVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL 584


>gi|194239668 SHC (Src homology 2 domain containing) transforming
           protein 1 isoform 4 [Homo sapiens]
          Length = 473

 Score =  976 bits (2524), Expect = 0.0
 Identities = 473/473 (100%), Positives = 473/473 (100%)

Query: 111 MNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCV 170
           MNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCV
Sbjct: 1   MNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCV 60

Query: 171 EVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGM 230
           EVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGM
Sbjct: 61  EVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGM 120

Query: 231 PITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHIL 290
           PITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHIL
Sbjct: 121 PITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHIL 180

Query: 291 ECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYY 350
           ECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYY
Sbjct: 181 ECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYY 240

Query: 351 NDFPGKEPPLGGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQM 410
           NDFPGKEPPLGGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQM
Sbjct: 241 NDFPGKEPPLGGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQM 300

Query: 411 PPPPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRV 470
           PPPPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRV
Sbjct: 301 PPPPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRV 360

Query: 471 PPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQP 530
           PPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQP
Sbjct: 361 PPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQP 420

Query: 531 KHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL 583
           KHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL
Sbjct: 421 KHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL 473


>gi|32261324 SHC (Src homology 2 domain containing) transforming
           protein 1 isoform 2 [Homo sapiens]
          Length = 474

 Score =  972 bits (2512), Expect = 0.0
 Identities = 473/474 (99%), Positives = 473/474 (99%), Gaps = 1/474 (0%)

Query: 111 MNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCV 170
           MNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCV
Sbjct: 1   MNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCV 60

Query: 171 EVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGM 230
           EVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGM
Sbjct: 61  EVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGM 120

Query: 231 PITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHIL 290
           PITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHIL
Sbjct: 121 PITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHIL 180

Query: 291 ECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYY 350
           ECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYY
Sbjct: 181 ECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYY 240

Query: 351 NDFPGKEPPLGGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQM 410
           NDFPGKEPPLGGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQM
Sbjct: 241 NDFPGKEPPLGGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQM 300

Query: 411 PPPPPCP-GRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALR 469
           PPPPPCP GRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALR
Sbjct: 301 PPPPPCPAGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALR 360

Query: 470 VPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQ 529
           VPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQ
Sbjct: 361 VPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQ 420

Query: 530 PKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL 583
           PKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL
Sbjct: 421 PKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL 474


>gi|169790811 SHC (Src homology 2 domain containing) transforming
           protein 2 [Homo sapiens]
          Length = 582

 Score =  505 bits (1300), Expect = e-143
 Identities = 290/616 (47%), Positives = 369/616 (59%), Gaps = 89/616 (14%)

Query: 21  LEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCSFFPRMSNLRLANP------- 73
           + +G  G  PP            P  PP P  ++PTT C+  PRM   + A P       
Sbjct: 1   MTQGPGGRAPP-----------APPAPPEP--EAPTTFCALLPRMPQWKFAAPGGFLGRG 47

Query: 74  ------AGGRPGSKGEPGRAADDG-----EGIVGAAMPDSG---PLPLL---QDMNKLSG 116
                 AG   G+  +P  A   G       ++GA  P      PLP L   +       
Sbjct: 48  PAAARAAGASGGADPQPEPAGPGGVPALAAAVLGACEPRCAAPCPLPALSRCRGAGSRGS 107

Query: 117 GGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSM 176
            GGR     G      EW R GSF++KP  GWLHP+ +V+GPGVSY+VRYMGC+EVL+SM
Sbjct: 108 RGGRGAAGSGDAAAAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRYMGCIEVLRSM 167

Query: 177 RALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTV 236
           R+LDFNTRTQVTREAI+ + EAVPG +G+ +++ P ++ L+S+LG+SNL+FAGM I++ +
Sbjct: 168 RSLDFNTRTQVTREAINRLHEAVPGVRGSWKKKAP-NKALASVLGKSNLRFAGMSISIHI 226

Query: 237 STSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGL 296
           ST  L+L     +Q+IANHHM SISFASGGD D  +YVAYVAKDP+NQRACHILEC EGL
Sbjct: 227 STDGLSLSVPATRQVIANHHMPSISFASGGDTDMTDYVAYVAKDPINQRACHILECCEGL 286

Query: 297 AQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGK 356
           AQ +IST+GQAFELRFKQYL +PPK+  P +R+AG + SAW +EE+   +H YYN  PGK
Sbjct: 287 AQSIISTVGQAFELRFKQYLHSPPKVALPPERLAGPEESAWGDEEDS-LEHNYYNSIPGK 345

Query: 357 EPPLGGVVDMRLREGAAPGAARPTAPNAQTPSHLGA-TLP-----VGQPVGGDPEVRKQM 410
           EPPLGG+VD RL        A        +PS   A +LP      G    GD  V+   
Sbjct: 346 EPPLGGLVDSRL--ALTQPCALTALDQGPSPSLRDACSLPWDVGSTGTAPPGDGYVQADA 403

Query: 411 PPPPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRV 470
             PP        ++  YVN Q LD             P    S  +DLFDM+PFEDAL++
Sbjct: 404 RGPPD------HEEHLYVNTQGLDA------------PEPEDSPKKDLFDMRPFEDALKL 445

Query: 471 ---------------------PPPPQSVSMA---EQLRGEPWFHGKLSRREAEALLQLNG 506
                                 PP +   +A   EQLR EPW+HG++SRR AE +L+ +G
Sbjct: 446 HECSVAAGVTAAPLPLEDQWPSPPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLRADG 505

Query: 507 DFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPI 566
           DFLVR+S T PGQYVLTG+ +GQPKHLLLVDPEGVVRTKD  FES+SHLI +H+ N  PI
Sbjct: 506 DFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGVVRTKDVLFESISHLIDHHLQNGQPI 565

Query: 567 ISAGSELCLQQPVERK 582
           ++A SEL L+  V R+
Sbjct: 566 VAAESELHLRGVVSRE 581


>gi|224586793 src homology 2 domain-containing transforming protein
           C3 [Homo sapiens]
          Length = 594

 Score =  500 bits (1287), Expect = e-141
 Identities = 301/633 (47%), Positives = 380/633 (60%), Gaps = 98/633 (15%)

Query: 6   PKPKYNPLRNESLSSLEE--------GASGSTPPEELPSPSASSL--GPILPPLPGDDSP 55
           P+ KYN  RN+S++S+++        G  G          +A  L  G  L   P DD P
Sbjct: 3   PRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAP-DDGP 61

Query: 56  TTLCSFFPRMSNLRLANP------------AGGR-PGSKGEPGRAADDGEGIVGAAMPDS 102
            +L     ++S+L+L++             AG R  GS   P  AA DG        P +
Sbjct: 62  GSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSA------PSA 115

Query: 103 GPLPLLQDMNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSY 162
              P +    K             G+ G E   R       P RG  H +D+V+GPGV+Y
Sbjct: 116 PRAPAMSAARK-------------GRPGDEPLPR-------PPRGAPHASDQVLGPGVTY 155

Query: 163 LVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGR 222
           +V+Y+GC+EVL+SMR+LDF+TRTQ+TREAIS VCEAVPGAKGA ++RKP S+ LSSILG+
Sbjct: 156 VVKYLGCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGK 215

Query: 223 SNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPV 282
           SNL+FAGM I+LT+ST+SLNL   D KQIIANHHM+SISFASGGDPDT +YVAYVAKDPV
Sbjct: 216 SNLQFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPV 275

Query: 283 NQRACHILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEE 342
           N+RACHILEC +GLAQDVI +IGQAFELRFKQYL+ P K+   HDRM   D   W EEE 
Sbjct: 276 NRRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHDRMQSLD-EPWTEEEG 334

Query: 343 EPPDHQYYNDFPGKEPPLGGVVDMRLREGAAPGAARPTAPNAQT---PSHLGATL----- 394
           +  DH YYN  P K PP GG +D RL+           A   QT     HLG T      
Sbjct: 335 DGSDHPYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQ 394

Query: 395 --PVGQ---PVGGDPEVRKQMPPPPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPA 449
             P+ Q    +   PE +  + P          + P+YVN Q +         A P   +
Sbjct: 395 QTPLRQGSSDIYSTPEGKLHVAPTG--------EAPTYVNTQQIPPQ------AWPAAVS 440

Query: 450 INGSAPR-DLFDMKPFEDALR-------------------VPPPPQSVSMAEQLRGEPWF 489
              S+PR DLFDMKPFEDAL+                   V P      M E+L+ E W+
Sbjct: 441 SAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETWY 500

Query: 490 HGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRF 549
            G++SR+EAE LL+ +GDFLVR+STT PG +VLTG+ +GQ KHLLLVDPEG +RTKD  F
Sbjct: 501 QGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIRTKDRVF 560

Query: 550 ESVSHLISYHMDNHLPIISAGSELCLQQPVERK 582
           +S+SHLI++H+++ LPI+SAGSELCLQQPVERK
Sbjct: 561 DSISHLINHHLESSLPIVSAGSELCLQQPVERK 593


>gi|222446609 rai-like protein [Homo sapiens]
          Length = 630

 Score =  473 bits (1216), Expect = e-133
 Identities = 300/639 (46%), Positives = 370/639 (57%), Gaps = 110/639 (17%)

Query: 7   KPKYNPLRNESLSSLEEGASG-STPPEELPSPSASSLGPILPP----LPGDDSPTTLCSF 61
           + KY+  RNES++SL+EG+SG S   +  P P   +L P LP     LP  +SPT LC+ 
Sbjct: 27  RAKYSRFRNESITSLDEGSSGGSVGNKGSPQPPHPALAPHLPTEDATLPSQESPTPLCTL 86

Query: 62  FPRMSNLRLANPA----------------------GGRPGSKG---------EPGRAADD 90
            PRM++++LANPA                         PGS G           G A   
Sbjct: 87  IPRMASMKLANPATLLSLKNFCLGTKEVPRLKLQESRDPGSSGPSSPETSLSRSGTAPPP 146

Query: 91  GEGIVG----AAMPDSGPLPLLQDMNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTR 146
            + +VG    A  PDS PLP          G G  T                      +R
Sbjct: 147 QQDLVGHRATALTPDSCPLP----------GPGEPTL--------------------RSR 176

Query: 147 GWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGAT 206
              H    ++G G++Y VRYMGCVEVLQSMR+LDF  RTQVTREAIS +CEAVPGA GA 
Sbjct: 177 QDRHFLQHLLGMGMNYCVRYMGCVEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAI 236

Query: 207 RRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGG 266
           ++RKP  + LS++LG+SNL+F+GM I LT+ST SL LM  D +QIIANHHMQSISFASGG
Sbjct: 237 KKRKPPVKFLSTVLGKSNLQFSGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISFASGG 296

Query: 267 DPDTAEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPH 326
           DPDT +YVAYVAKDPVNQRACHILEC  G+AQDVISTIGQAFELRFKQYL+NP    +  
Sbjct: 297 DPDTTDYVAYVAKDPVNQRACHILECHNGMAQDVISTIGQAFELRFKQYLKNPSLNTSCE 356

Query: 327 DRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAA------------- 373
                 D  A     EE  DH+YYN+ PGK+PP+GGV DMR++  A              
Sbjct: 357 SEEVHIDSHA-----EEREDHEYYNEIPGKQPPVGGVSDMRIKVQATEQMAYCPIQCEKL 411

Query: 374 ---PGAARPTA--PNAQTPSH-LGATLPVGQPVGGDPEVRKQMPPPPPCPGRELFDDPSY 427
              PG ++ ++   N    S  +G   P G     D  + K       C   +LFDDP Y
Sbjct: 412 CYLPGNSKCSSVYENCLEQSRAIGNVHPRGVQSQRDTSLLKH-----TC-RVDLFDDPCY 465

Query: 428 VNVQNLDKARQAVGGAGPPNPAIN----GSAPRDLFDMKPFEDALRVPPPPQSV-SMAEQ 482
           +N Q L     + G      P  +    G AP     ++P   A   P    S+  + +Q
Sbjct: 466 INTQALQSTPGSAGNQRSAQPLGSPWHCGKAPE---TVQP--GATAQPASSHSLPHIKQQ 520

Query: 483 LRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVV 542
           L  E  +HGKLSR+ AE+LL  +GDFLVRES T+PGQYVL+GLQ GQ KHLLLVDPEG V
Sbjct: 521 LWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKV 580

Query: 543 RTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVER 581
           RTKDH F++V HLI YHMDN LPIIS+GSE+ L+QPV +
Sbjct: 581 RTKDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRK 619


>gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo
           sapiens]
          Length = 475

 Score =  164 bits (415), Expect = 2e-40
 Identities = 99/220 (45%), Positives = 126/220 (57%), Gaps = 45/220 (20%)

Query: 387 PSHLGATLPVGQPVGGDPEVRKQMPPPPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPP 446
           P  +G+T   G    GD  V+     PP        ++  YVN Q LD            
Sbjct: 276 PWDVGST---GTAPPGDGYVQADARGPPD------HEEHLYVNTQGLDA----------- 315

Query: 447 NPAINGSAPRDLFDMKPFEDALRV---------------------PPPPQSVSMA---EQ 482
            P    S  +DLFDM+PFEDAL++                      PP +   +A   EQ
Sbjct: 316 -PEPEDSPKKDLFDMRPFEDALKLHECSVAAGVTAAPLPLEDQWPSPPTRRAPVAPTEEQ 374

Query: 483 LRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVV 542
           LR EPW+HG++SRR AE +L+ +GDFLVR+S T PGQYVLTG+ +GQPKHLLLVDPEGVV
Sbjct: 375 LRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGVV 434

Query: 543 RTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERK 582
           RTKD  FES+SHLI +H+ N  PI++A SEL L+  V R+
Sbjct: 435 RTKDVLFESISHLIDHHLQNGQPIVAAESELHLRGVVSRE 474



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 24/29 (82%), Positives = 28/29 (96%)

Query: 166 YMGCVEVLQSMRALDFNTRTQVTREAISL 194
           YMGC+EVL+SMR+LDFNTRTQVTR+A SL
Sbjct: 247 YMGCIEVLRSMRSLDFNTRTQVTRDACSL 275


>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
          Length = 822

 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 36/106 (33%), Positives = 61/106 (57%), Gaps = 2/106 (1%)

Query: 477 VSMAEQ-LRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLL 535
           +S++E+ L  + W+HG + R EA+ LL+  GDFLVRES   PG+YVL+    GQ +H ++
Sbjct: 448 ISISEKPLAEQDWYHGAIPRIEAQELLKKQGDFLVRESHGKPGEYVLSVYSDGQRRHFII 507

Query: 536 VDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVER 581
              + + R +   F ++  LI +H      +I+  S + L  P+ +
Sbjct: 508 QYVDNMYRFEGTGFSNIPQLIDHHYTTK-QVITKKSGVVLLNPIPK 552


>gi|208609985 SH2 domain containing 3A [Homo sapiens]
          Length = 576

 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 36/98 (36%), Positives = 52/98 (53%), Gaps = 9/98 (9%)

Query: 481 EQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLV---- 536
           E L G+PW+HG LSR++AEALLQ NGDFLVR S +  G  V++    G   H  +     
Sbjct: 8   EDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVAL 67

Query: 537 -----DPEGVVRTKDHRFESVSHLISYHMDNHLPIISA 569
                 P  + + +D +F S+  L+  +M    P+  A
Sbjct: 68  RPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQA 105


>gi|224926824 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
          Length = 671

 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 39/104 (37%), Positives = 57/104 (54%), Gaps = 6/104 (5%)

Query: 474 PQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSG 528
           P+     + L G PWFHG LSR +A  L+   G      FLVR+S T  G+YVLT    G
Sbjct: 513 PEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQG 572

Query: 529 QPKHL-LLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 571
           + KHL L ++ EG  R +   F+S+  ++ +   + +P+ S GS
Sbjct: 573 KAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616


>gi|224926830 SH2B adaptor protein 1 isoform 3 [Homo sapiens]
          Length = 683

 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 39/104 (37%), Positives = 57/104 (54%), Gaps = 6/104 (5%)

Query: 474 PQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSG 528
           P+     + L G PWFHG LSR +A  L+   G      FLVR+S T  G+YVLT    G
Sbjct: 513 PEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQG 572

Query: 529 QPKHL-LLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 571
           + KHL L ++ EG  R +   F+S+  ++ +   + +P+ S GS
Sbjct: 573 KAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616


>gi|224926828 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
          Length = 671

 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 39/104 (37%), Positives = 57/104 (54%), Gaps = 6/104 (5%)

Query: 474 PQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSG 528
           P+     + L G PWFHG LSR +A  L+   G      FLVR+S T  G+YVLT    G
Sbjct: 513 PEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQG 572

Query: 529 QPKHL-LLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 571
           + KHL L ++ EG  R +   F+S+  ++ +   + +P+ S GS
Sbjct: 573 KAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616


>gi|224926826 SH2B adaptor protein 1 isoform 1 [Homo sapiens]
          Length = 756

 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 39/104 (37%), Positives = 57/104 (54%), Gaps = 6/104 (5%)

Query: 474 PQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSG 528
           P+     + L G PWFHG LSR +A  L+   G      FLVR+S T  G+YVLT    G
Sbjct: 513 PEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQG 572

Query: 529 QPKHL-LLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 571
           + KHL L ++ EG  R +   F+S+  ++ +   + +P+ S GS
Sbjct: 573 KAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616


>gi|224926822 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
          Length = 671

 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 39/104 (37%), Positives = 57/104 (54%), Gaps = 6/104 (5%)

Query: 474 PQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSG 528
           P+     + L G PWFHG LSR +A  L+   G      FLVR+S T  G+YVLT    G
Sbjct: 513 PEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQG 572

Query: 529 QPKHL-LLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 571
           + KHL L ++ EG  R +   F+S+  ++ +   + +P+ S GS
Sbjct: 573 KAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616


>gi|7705318 GULP, engulfment adaptor PTB domain containing 1 [Homo
           sapiens]
          Length = 304

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 69/342 (20%), Positives = 124/342 (36%), Gaps = 74/342 (21%)

Query: 139 SFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEA 198
           +F  K  + W+H  + +    + Y  +++G  EV Q          T+V R+A+      
Sbjct: 4   AFSRKKDKTWMHTPEALSKHFIPYNAKFLGSTEVEQPKG-------TEVVRDAV------ 50

Query: 199 VPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQ 258
                    R+   +R +    G+   K     + L +S   + ++    K++  N  + 
Sbjct: 51  ---------RKLKFARHIKKSEGQKIPK-----VELQISIYGVKILEPKTKEVQHNCQLH 96

Query: 259 SISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLRN 318
            ISF +    D   +         N+  C++ +  E  A+++  TIGQAF+L ++++L +
Sbjct: 97  RISFCADDKTDKRIFTFICKDSESNKHLCYVFDS-EKCAEEITLTIGQAFDLAYRKFLES 155

Query: 319 PPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAAPGAAR 378
             K V    ++AG      D E E         D   +         +R+ + +AP A  
Sbjct: 156 GGKDVETRKQIAGLQKRIQDLETENMELKNKVQDLENQ---------LRITQVSAPPAGS 206

Query: 379 PTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPGRELFDDPSYVNVQNLDKARQ 438
            T                                 P  P  ++FD   +  + +      
Sbjct: 207 MT---------------------------------PKSPSTDIFDMIPFSPISHQSSMPT 233

Query: 439 AVGGAGPPNPAINGSAPRDLFDMKPFE----DALRVPPPPQS 476
             G   PP P+ +    RDLF  +PF+     A   PP  QS
Sbjct: 234 RNGTQPPPVPSRSTEIKRDLFGAEPFDPFNCGAADFPPDIQS 275


>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
          Length = 764

 Score = 60.1 bits (144), Expect = 6e-09
 Identities = 34/104 (32%), Positives = 54/104 (51%), Gaps = 2/104 (1%)

Query: 464 FEDALRVPPPPQSVSMAEQ-LRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVL 522
           F     +PPP Q +   ++ L  + W+HG + R E   LL  +GDFLVRES     +YVL
Sbjct: 377 FRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGKQ-EYVL 435

Query: 523 TGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPI 566
           + L  G P+H ++   + + R +   F S+  LI + +    P+
Sbjct: 436 SVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPL 479


>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
          Length = 822

 Score = 60.1 bits (144), Expect = 6e-09
 Identities = 34/104 (32%), Positives = 54/104 (51%), Gaps = 2/104 (1%)

Query: 464 FEDALRVPPPPQSVSMAEQ-LRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVL 522
           F     +PPP Q +   ++ L  + W+HG + R E   LL  +GDFLVRES     +YVL
Sbjct: 435 FRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGKQ-EYVL 493

Query: 523 TGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPI 566
           + L  G P+H ++   + + R +   F S+  LI + +    P+
Sbjct: 494 SVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPL 537


>gi|41281821 SH2 domain containing 3C isoform a [Homo sapiens]
          Length = 860

 Score = 60.1 bits (144), Expect = 6e-09
 Identities = 58/215 (26%), Positives = 90/215 (41%), Gaps = 21/215 (9%)

Query: 355 GKEPPL--GGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPP 412
           G +P L  GGV D    E A     + T P   TP    A  P    V  DP +RK    
Sbjct: 101 GPKPNLVPGGVPDPPGLEAAKEVMVKATGPLEDTP----AMEPNPSAVEVDP-IRK---- 151

Query: 413 PPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVPP 472
            P  P  ++ ++    +V +     +A G     +  +  S  + + D  P  + L    
Sbjct: 152 -PEVPTGDVEEERPPRDVHS----ERAAGEPEAGSDYVKFSKEKYILDSSP--EKLHKEL 204

Query: 473 PPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKH 532
             +    +  LR   W+HG++ R  +E L+Q NGDFL+R+S T+ G YVLT     Q  H
Sbjct: 205 EEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALH 264

Query: 533 LLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPII 567
             +     VV      +  + +L      +H+P +
Sbjct: 265 FKI---NKVVVKAGESYTHIQYLFEQESFDHVPAL 296


>gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens]
          Length = 825

 Score = 59.7 bits (143), Expect = 7e-09
 Identities = 41/140 (29%), Positives = 69/140 (49%), Gaps = 16/140 (11%)

Query: 453 SAPRDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRE 512
           S  R + D  P  + L+     + +  +E LR   W+HG++ R+ +E L+Q +GDFLVR+
Sbjct: 121 SKERHIMDRTP--EKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRD 178

Query: 513 STTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKD-----------HRFESVSHLISYHMD 561
           S ++PG +VLT       +H  +     V+R  +             F+S+  L+  ++ 
Sbjct: 179 SLSSPGNFVLTCQWKNLAQHFKI--NRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVG 236

Query: 562 NHLPIISAGSELCLQQPVER 581
           N  P IS  S   + QP+ R
Sbjct: 237 NRRP-ISQQSGAIIFQPINR 255


>gi|4885455 SH2B adaptor protein 3 [Homo sapiens]
          Length = 575

 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 48/173 (27%), Positives = 74/173 (42%), Gaps = 19/173 (10%)

Query: 400 VGGDPEVRKQMPPPPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLF 459
           VG + ++   M     C GR L    + +++ +  +   +    G  +    G++P  L 
Sbjct: 289 VGDEQQLNSWMAELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLL 348

Query: 460 DMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGD-----FLVREST 514
           D             P        L   PWFHG +SR +A  L+QL G      FLVR+S 
Sbjct: 349 D-------------PACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSE 395

Query: 515 TTPGQYVLTGLQSGQPKHL-LLVDPEGVVRTKDHRFESVSHLISYHMDNHLPI 566
           T  G+YVLT    G  KHL L +   G  R +   F SV  ++ +   + +P+
Sbjct: 396 TRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLHHFQRSPIPL 448


>gi|242247193 SH2B adaptor protein 2 [Homo sapiens]
          Length = 675

 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 35/96 (36%), Positives = 53/96 (55%), Gaps = 6/96 (6%)

Query: 482 QLRGEPWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSGQPKHL-LL 535
           +L   PWFHG LSR +A  L+   G      F++R+S T PG+YVLT    G+ KHL L 
Sbjct: 454 ELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLS 513

Query: 536 VDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 571
           ++  G    +   F+SV  ++ +   + +P+ S GS
Sbjct: 514 LNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGS 549


>gi|216547763 SH2 domain containing 3C isoform b [Homo sapiens]
          Length = 703

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 37/130 (28%), Positives = 58/130 (44%), Gaps = 8/130 (6%)

Query: 441 GGAGPPNPA---INGSAPRDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRRE 497
           G AG P      +  S  + + D  P  + L      +    +  LR   W+HG++ R  
Sbjct: 15  GAAGEPEAGSDYVKFSKEKYILDSSP--EKLHKELEEELKLSSTDLRSHAWYHGRIPREV 72

Query: 498 AEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLIS 557
           +E L+Q NGDFL+R+S T+ G YVLT     Q  H  +     VV      +  + +L  
Sbjct: 73  SETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKI---NKVVVKAGESYTHIQYLFE 129

Query: 558 YHMDNHLPII 567
               +H+P +
Sbjct: 130 QESFDHVPAL 139


>gi|216547801 SH2 domain containing 3C isoform e [Homo sapiens]
          Length = 700

 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 3/85 (3%)

Query: 483 LRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVV 542
           LR   W+HG++ R  +E L+Q NGDFL+R+S T+ G YVLT     Q  H  +     VV
Sbjct: 55  LRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKI---NKVV 111

Query: 543 RTKDHRFESVSHLISYHMDNHLPII 567
                 +  + +L      +H+P +
Sbjct: 112 VKAGESYTHIQYLFEQESFDHVPAL 136


>gi|216547790 SH2 domain containing 3C isoform d [Homo sapiens]
          Length = 702

 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 3/85 (3%)

Query: 483 LRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVV 542
           LR   W+HG++ R  +E L+Q NGDFL+R+S T+ G YVLT     Q  H  +     VV
Sbjct: 57  LRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKI---NKVV 113

Query: 543 RTKDHRFESVSHLISYHMDNHLPII 567
                 +  + +L      +H+P +
Sbjct: 114 VKAGESYTHIQYLFEQESFDHVPAL 138


>gi|222537752 Src homology 2 domain containing transforming protein
           D [Homo sapiens]
          Length = 340

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 60/188 (31%), Positives = 82/188 (43%), Gaps = 15/188 (7%)

Query: 397 GQPVGGDPEVRKQMPPPPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPR 456
           G P G  P  + +MP     P  E +D P      ++ +A  AV    P      GSA +
Sbjct: 158 GPPSGQKPR-QSRMPQEDERPADE-YDQPWEWKKDHISRAF-AVQFDSPEWERTPGSA-K 213

Query: 457 DLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQL--NGDFLVREST 514
           +L    P     R P P + V  A  L  +PWFHG L+R +AE+LL L   G +LVR S 
Sbjct: 214 ELRRPPP-----RSPQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSE 268

Query: 515 TTPGQYVLTGLQSGQPKHLLLV---DPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 571
           T P    L+   S    HL      + + V+      F SV  L+ ++    LP+  A  
Sbjct: 269 TNPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGA-E 327

Query: 572 ELCLQQPV 579
            L L  PV
Sbjct: 328 HLALLYPV 335


>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
          Length = 1265

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 44/120 (36%), Positives = 58/120 (48%), Gaps = 16/120 (13%)

Query: 474 PQSVSMAEQLRGEPWFHGKLSRR-EAEALLQ--------LNGDFLVRESTTTPGQYVLTG 524
           PQ +   E   GE WFH K+ +R  AE LLQ         +G FLVRES T P  Y L+ 
Sbjct: 518 PQDIPPTELHFGEKWFHKKVEKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSF 577

Query: 525 LQSGQPKHLLLVDP-EG----VVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPV 579
            +SG+ +H  +    EG       T +  F S+  LI ++ + HL    A  EL L  PV
Sbjct: 578 WRSGRVQHCRIRSTMEGGTLKYYLTDNLTFSSIYALIQHYRETHLR--CAEFELRLTDPV 635



 Score = 37.0 bits (84), Expect = 0.050
 Identities = 27/83 (32%), Positives = 42/83 (50%), Gaps = 5/83 (6%)

Query: 486 EPWFHGKLSRREAEALLQ---LNGDFLVRESTTTPGQYVLTGLQSGQPKHLLL-VDPEGV 541
           +PW++  LSR EAE +L     +G FL+R+   +   Y +T    G+ KH  +  D    
Sbjct: 644 KPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREGS-DSYAITFRARGKVKHCRINRDGRHF 702

Query: 542 VRTKDHRFESVSHLISYHMDNHL 564
           V      FES+  L+SY+  + L
Sbjct: 703 VLGTSAYFESLVELVSYYEKHSL 725


>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
          Length = 377

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 31/112 (27%), Positives = 55/112 (49%), Gaps = 7/112 (6%)

Query: 471 PPPPQS----VSMAEQLRGEPWFHGKLSRREAEALLQLNG---DFLVRESTTTPGQYVLT 523
           P PPQ      S+  +  G PW++GK++R +AE  L   G   DFL+R+S ++P  + ++
Sbjct: 261 PSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVS 320

Query: 524 GLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCL 575
               G+ KH  +   E V      +F ++  L+ ++    +     G +L L
Sbjct: 321 LKAQGKNKHFKVQLKETVYCIGQRKFSTMEELVEHYKKAPIFTSEQGEKLYL 372


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 31/91 (34%), Positives = 49/91 (53%), Gaps = 4/91 (4%)

Query: 473 PPQSVSMAEQLRGEPWFHGKLSRREAEALLQ--LNGDFLVRESTTTPGQYVLTGLQSGQP 530
           P   ++    L    W+HG +SR  AE LL   +NG FLVRES ++PGQ  ++    G+ 
Sbjct: 143 PSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRV 202

Query: 531 KHLLL-VDPEG-VVRTKDHRFESVSHLISYH 559
            H  +    +G V  T + RF +++ L+ +H
Sbjct: 203 YHYRINTTADGKVYVTAESRFSTLAELVHHH 233


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 31/91 (34%), Positives = 49/91 (53%), Gaps = 4/91 (4%)

Query: 473 PPQSVSMAEQLRGEPWFHGKLSRREAEALLQ--LNGDFLVRESTTTPGQYVLTGLQSGQP 530
           P   ++    L    W+HG +SR  AE LL   +NG FLVRES ++PGQ  ++    G+ 
Sbjct: 158 PSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRV 217

Query: 531 KHLLL-VDPEG-VVRTKDHRFESVSHLISYH 559
            H  +    +G V  T + RF +++ L+ +H
Sbjct: 218 YHYRINTTADGKVYVTAESRFSTLAELVHHH 248


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.135    0.414 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,824,807
Number of Sequences: 37866
Number of extensions: 1813326
Number of successful extensions: 10152
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 90
Number of HSP's successfully gapped in prelim test: 439
Number of HSP's that attempted gapping in prelim test: 7793
Number of HSP's gapped (non-prelim): 2604
length of query: 583
length of database: 18,247,518
effective HSP length: 108
effective length of query: 475
effective length of database: 14,157,990
effective search space: 6725045250
effective search space used: 6725045250
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.