Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 11321634
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11321634 CD2-associated protein [Homo sapiens]
(639 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11321634 CD2-associated protein [Homo sapiens] 1280 0.0
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 395 e-110
gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo ... 319 4e-87
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 157 2e-38
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 97 6e-20
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 97 6e-20
gi|242117948 SH3 domain-containing protein C1orf113 isoform 2 [H... 94 3e-19
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 91 4e-18
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 91 4e-18
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 91 4e-18
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 87 5e-17
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 87 5e-17
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 87 5e-17
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 83 7e-16
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 83 7e-16
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 83 7e-16
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 83 7e-16
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 83 7e-16
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 83 7e-16
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 83 7e-16
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 83 7e-16
gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s... 82 2e-15
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s... 79 2e-14
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s... 79 2e-14
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa... 79 2e-14
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s... 79 2e-14
gi|55956916 myosin IE [Homo sapiens] 72 2e-12
gi|39930351 dynamin binding protein [Homo sapiens] 70 6e-12
gi|182765466 FCH and double SH3 domains 2 [Homo sapiens] 67 5e-11
gi|89886447 nitric oxide synthase trafficker isoform 2 [Homo sap... 65 2e-10
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 1280 bits (3312), Expect = 0.0
Identities = 639/639 (100%), Positives = 639/639 (100%)
Query: 1 MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRE 60
MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRE
Sbjct: 1 MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRE 60
Query: 61 TEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYI 120
TEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYI
Sbjct: 61 TEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYI 120
Query: 121 PQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDS 180
PQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDS
Sbjct: 121 PQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDS 180
Query: 181 ETVLAGPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKK 240
ETVLAGPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKK
Sbjct: 181 ETVLAGPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKK 240
Query: 241 PEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLIS 300
PEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLIS
Sbjct: 241 PEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLIS 300
Query: 301 KETGEAGWWRGELNGKEGVFPDNFAVQINELDKDFPKPKKPPPPAKAPAPKPELIAAEKK 360
KETGEAGWWRGELNGKEGVFPDNFAVQINELDKDFPKPKKPPPPAKAPAPKPELIAAEKK
Sbjct: 301 KETGEAGWWRGELNGKEGVFPDNFAVQINELDKDFPKPKKPPPPAKAPAPKPELIAAEKK 360
Query: 361 YFSLKPEEKDEKSTLEQKPSKPAAPQVPPKKPTPPTKASNLLRSSGTVYPKRPEKPVPPP 420
YFSLKPEEKDEKSTLEQKPSKPAAPQVPPKKPTPPTKASNLLRSSGTVYPKRPEKPVPPP
Sbjct: 361 YFSLKPEEKDEKSTLEQKPSKPAAPQVPPKKPTPPTKASNLLRSSGTVYPKRPEKPVPPP 420
Query: 421 PPIAKINGEVSSISSKFETEPVSKLKLDSEQLPLRPKSVDFDSLTVRTSKETDVVNFDDI 480
PPIAKINGEVSSISSKFETEPVSKLKLDSEQLPLRPKSVDFDSLTVRTSKETDVVNFDDI
Sbjct: 421 PPIAKINGEVSSISSKFETEPVSKLKLDSEQLPLRPKSVDFDSLTVRTSKETDVVNFDDI 480
Query: 481 ASSENLLHLTANRPKMPGRRLPGRFNGGHSPTHSPEKILKLPKEEDSANLKPSELKKDTC 540
ASSENLLHLTANRPKMPGRRLPGRFNGGHSPTHSPEKILKLPKEEDSANLKPSELKKDTC
Sbjct: 481 ASSENLLHLTANRPKMPGRRLPGRFNGGHSPTHSPEKILKLPKEEDSANLKPSELKKDTC 540
Query: 541 YSPKPSVYLSTPSSASKANTTAFLTPLEIKAKVETDDVKKNSLDELRAQIIELLCIVEAL 600
YSPKPSVYLSTPSSASKANTTAFLTPLEIKAKVETDDVKKNSLDELRAQIIELLCIVEAL
Sbjct: 541 YSPKPSVYLSTPSSASKANTTAFLTPLEIKAKVETDDVKKNSLDELRAQIIELLCIVEAL 600
Query: 601 KKDHGKELEKLRKDLEEEKTMRSNLEMEIEKLKKAVLSS 639
KKDHGKELEKLRKDLEEEKTMRSNLEMEIEKLKKAVLSS
Sbjct: 601 KKDHGKELEKLRKDLEEEKTMRSNLEMEIEKLKKAVLSS 639
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 395 bits (1014), Expect = e-110
Identities = 263/704 (37%), Positives = 375/704 (53%), Gaps = 106/704 (15%)
Query: 1 MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRE 60
MV+ IVE+DY A HDDELTI VGEII N++K ++ GW EG++NGRRG+FPDNFV+EIK+E
Sbjct: 1 MVEAIVEFDYQAQHDDELTISVGEIITNIRK-EDGGWWEGQINGRRGLFPDNFVREIKKE 59
Query: 61 TEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQT---KNIKKKTKKRQCKVLF 117
K D L K + +P+G +T N + + ++R+C+V F
Sbjct: 60 --MKKDPLTNKAPEK----------PLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAF 107
Query: 118 EYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQ 177
Y+PQN+DELELKVGDII++ EVEEGWW G LN K G+FPSNF+KEL D E +Q
Sbjct: 108 SYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESD-ELGISQ 166
Query: 178 DD--SETVLAGPTSPIPSLGNVSET----ASGSVT----QPKKIRGIGFGDIFKEGSVKL 227
D+ S++ L T G+ S T A+G+V QPKK++G+GFGDIFK+ +KL
Sbjct: 167 DEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKL 226
Query: 228 RTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDE 287
R R+ E + EK I + L T + + +KT+ + + K+K+YC+ +F YE N+DE
Sbjct: 227 RPRSIEVENDFLPVEK-TIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDE 285
Query: 288 LTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQI-NELDKDFPKPKKPPPPAK 346
LT KEG+I+ LI+K+ + GWW GELNG+ GVFPDNF + + +K+ +PKKPPPP+
Sbjct: 286 LTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPS- 344
Query: 347 APAPKPELIAAEKKYFSLK---------PEEKDEKSTLEQKP----SKPAAPQVPPKKPT 393
AP K E+K+ K P +EK E++P KP+ P +PPKKP
Sbjct: 345 APVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPR 404
Query: 394 PPTKASNLLRSSGTVYPKRPEKPVPPPPPIAKINGEVSSISSKFETEPVSKLKLDSEQLP 453
PP +N L G + P+RPE+PV P++ + DS ++
Sbjct: 405 PP--KTNSLSRPGALPPRRPERPV----------------------GPLTHTRGDSPKID 440
Query: 454 LRPKSVD--FDSLTVRTSKETDVVNFDDIASS-ENLLHLTANRPKMPGRRLPGR------ 504
L S+ D S + D+ FD + SS E L H T +RPK GRR P +
Sbjct: 441 LAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSS 500
Query: 505 -----FNGGHSPTHSPEKILKLPKEEDSANLKPSEL-------KKDTCYSPKPSVYL--- 549
SP E+ + L A+ K S+ PKP
Sbjct: 501 LSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGG 560
Query: 550 --------STPSSASKANTTA-------FLTPLEIKAKVETDDVKKNSLDELRAQIIELL 594
+ PS S + TA L E K K+E + +++ELR Q+ EL
Sbjct: 561 GGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELR 620
Query: 595 CIVEALKKDHGKELEKLRKDLEEEKTMRSNLEMEIEKLKKAVLS 638
I+E +K +E+++L +L+EEK +R L+ME+ +KKA+ S
Sbjct: 621 SIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQS 664
>gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo
sapiens]
Length = 628
Score = 319 bits (818), Expect = 4e-87
Identities = 215/599 (35%), Positives = 312/599 (52%), Gaps = 90/599 (15%)
Query: 103 NIKKKTKKRQCKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFV 162
N + + ++R+C+V F Y+PQN+DELELKVGDII++ EVEEGWW G LN K G+FPSNF+
Sbjct: 56 NKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFI 115
Query: 163 KELEVTDDGETHEAQDD--SETVLAGPTSPIPSLGNVSET----ASGSVT----QPKKIR 212
KEL D E +QD+ S++ L T G+ S T A+G+V QPKK++
Sbjct: 116 KELSGESD-ELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVK 174
Query: 213 GIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKE 272
G+GFGDIFK+ +KLR R+ E + EK I + L T + + +KT+ + + K+K+
Sbjct: 175 GVGFGDIFKDKPIKLRPRSIEVENDFLPVEK-TIGKKLPATTATPDSSKTEMDSRTKSKD 233
Query: 273 YCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQI-NEL 331
YC+ +F YE N+DELT KEG+I+ LI+K+ + GWW GELNG+ GVFPDNF + +
Sbjct: 234 YCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDF 293
Query: 332 DKDFPKPKKPPPPAKAPAPKPELIAAEKKYFSLK---------PEEKDEKSTLEQKP--- 379
+K+ +PKKPPPP+ AP K E+K+ K P +EK E++P
Sbjct: 294 EKEGNRPKKPPPPS-APVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLD 352
Query: 380 -SKPAAPQVPPKKPTPPTKASNLLRSSGTVYPKRPEKPVPPPPPIAKINGEVSSISSKFE 438
KP+ P +PPKKP PP +N L G + P+RPE+PV
Sbjct: 353 LQKPSVPAIPPKKPRPP--KTNSLSRPGALPPRRPERPV--------------------- 389
Query: 439 TEPVSKLKLDSEQLPLRPKSVD--FDSLTVRTSKETDVVNFDDIASS-ENLLHLTANRPK 495
P++ + DS ++ L S+ D S + D+ FD + SS E L H T +RPK
Sbjct: 390 -GPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPK 448
Query: 496 MPGRRLPGR-----------FNGGHSPTHSPEKILKLPKEEDSANLKPSEL-------KK 537
GRR P + SP E+ + L A+ K S+
Sbjct: 449 ATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDN 508
Query: 538 DTCYSPKPSVYL-----------STPSSASKANTTA-------FLTPLEIKAKVETDDVK 579
PKP + PS S + TA L E K K+E
Sbjct: 509 KASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASS 568
Query: 580 KNSLDELRAQIIELLCIVEALKKDHGKELEKLRKDLEEEKTMRSNLEMEIEKLKKAVLS 638
+ +++ELR Q+ EL I+E +K +E+++L +L+EEK +R L+ME+ +KKA+ S
Sbjct: 569 QAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQS 627
Score = 105 bits (262), Expect = 1e-22
Identities = 93/303 (30%), Positives = 130/303 (42%), Gaps = 80/303 (26%)
Query: 6 VEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETE--- 62
V + Y +DDEL ++VG+II V ++ EEGW EG LNG+ GMFP NF+KE+ E++
Sbjct: 68 VAFSYLPQNDDELELKVGDIIEVVGEV-EEGWWEGVLNGKTGMFPSNFIKELSGESDELG 126
Query: 63 -FKDDSLPIK--RERHGNVASLVQRISTYGLPAGG------IQPH--------------- 98
+D+ L RE G+ + ST A G IQP
Sbjct: 127 ISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKP 186
Query: 99 ---------------PQTKNIKKK-------------------TKKRQCKVLFEYIPQNE 124
P K I KK K CKV+F Y QN+
Sbjct: 187 IKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQND 246
Query: 125 DELELKVGDIID-INEE-VEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSET 182
DEL +K GDI+ IN++ ++ GWW G LN + G+FP NFVK L + E +
Sbjct: 247 DELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNR------- 299
Query: 183 VLAGPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPE 242
P P P V + +G+ + +I+ I E L RT E E++P+
Sbjct: 300 ----PKKPPPPSAPVIKQGAGTTERKHEIKKIP-----PERPEMLPNRTEEKERPEREPK 350
Query: 243 KPL 245
L
Sbjct: 351 LDL 353
Score = 67.8 bits (164), Expect = 3e-11
Identities = 37/106 (34%), Positives = 57/106 (53%), Gaps = 4/106 (3%)
Query: 225 VKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVE-ITKTDTEGKIKAKEYCRTLFAYEGT 283
++++ K PEKPL G S E I +T+ G+ + + C+ F+Y
Sbjct: 17 IEIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGE-RRRRRCQVAFSYLPQ 75
Query: 284 NEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQIN 329
N+DEL K G+II ++ + E GWW G LNGK G+FP NF +++
Sbjct: 76 NDDELELKVGDIIEVVGEV--EEGWWEGVLNGKTGMFPSNFIKELS 119
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 157 bits (398), Expect = 2e-38
Identities = 146/562 (25%), Positives = 233/562 (41%), Gaps = 134/562 (23%)
Query: 2 VDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRET 61
++ +V Y A +DEL++ G+++R V+ + GWL GE GR G+FP+ V+EI
Sbjct: 1 MEVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETL 60
Query: 62 EFKDDSL-PIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYI 120
++ P R G+ A P PQ R CKV F Y
Sbjct: 61 RGSGEARRPRCARRRGHPAK---------------HPRPQ----------RWCKVNFSYS 95
Query: 121 PQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDS 180
P+ DEL+L+ G+I+++ +E+E+GWW G N +LG FPSNFV+ L+
Sbjct: 96 PEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLD-------------- 141
Query: 181 ETVLAGPTSPIPSLGNVS-ETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEK 239
+GP PSLGN + S +P K+ + +
Sbjct: 142 ----SGP----PSLGNPDMPSVSPGPQRPPKLSSLAYDS--------------------- 172
Query: 240 KPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLI 299
P LQ+ + E R LF Y+ DEL + G+++ ++
Sbjct: 173 ---PPDYLQT------------------VSHPEVYRVLFDYQPEAPDELALRRGDVVKVL 211
Query: 300 SKETGEAGWWRGELNGKEGVFPDNFAVQINELDKDFPKPKKPPPPAKAPAPKPELIAAEK 359
SK T + GWW GE G+ GVFPDNF + PPPP K P+ ++++ E
Sbjct: 212 SKTTEDKGWWEGECQGRRGVFPDNFVL--------------PPPPIKKLVPR-KVVSRES 256
Query: 360 KYFSLKPEEKDEKSTLEQKPSKPAAPQVPPKKPT--PPTKASNLL-----------RSSG 406
+P++ K++L A P K T P++ S L +S G
Sbjct: 257 APIK-EPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDSQKLTSRDSGPNGGFQSGG 315
Query: 407 TVYPKRPEKPVPPPPPIAKINGEVSSISSKFETEPVSKLKL-DSEQLPLRPKSVDFDSLT 465
+ +P R P ++ + SS + V + + D P RP + +
Sbjct: 316 SYHPGRKRSKTQTPQQ-RSVSSQEEEHSSPVKAPSVKRTPMPDKTATPERPPAPE----N 370
Query: 466 VRTSKETDVVNFDDIASSENLLHLTANRPKMPGRRLPGRFNGGHSPTHSPEKILKLPKEE 525
+SK+ D + S E L L ++ +PG G+ +PEK++ E
Sbjct: 371 APSSKKIPAP--DKVPSPEKTLTL-GDKASIPGNSTSGKI-PAPDKVPTPEKMV---TPE 423
Query: 526 DSANL-KPSELKKDTCYSPKPS 546
D A++ + S + ++T KPS
Sbjct: 424 DKASIPENSIIPEETLTVDKPS 445
Score = 29.6 bits (65), Expect = 8.9
Identities = 23/91 (25%), Positives = 42/91 (46%), Gaps = 9/91 (9%)
Query: 333 KDFPKPKKPPPPAKAPAPKP---ELIAAEKKYFSLKPEEKDEKSTLEQKP-SKPAAPQVP 388
K+ P ++ +AP P+P E E K ++ + ++ L+ P S+PA
Sbjct: 521 KEDPSSQEEAHTPEAPPPQPPSSERCLGEMKCTLVRGDSSPRQAELKSGPASRPAL---- 576
Query: 389 PKKPTPPTKASNLLRSSGTVYPKRPEKPVPP 419
+KP P +A+ L + + + PE+ PP
Sbjct: 577 -EKPHPHEEATTLPEEAPSNDERTPEEEAPP 606
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 96.7 bits (239), Expect = 6e-20
Identities = 81/343 (23%), Positives = 155/343 (45%), Gaps = 66/343 (19%)
Query: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDS 67
Y + A D+ L ++I ++ Q++ W GE+ G++G FP ++VK I S
Sbjct: 922 YPWRAKKDNHLNFNKNDVITVLE--QQDMWWFGEVQGQKGWFPKSYVKLI---------S 970
Query: 68 LPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDEL 127
PI++ + S S + + +P + ++ Y + +L
Sbjct: 971 GPIRKSTSMDSGSSESPASLKRVASPAAKP---------VVSGEEFIAMYTYESSEQGDL 1021
Query: 128 ELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGP 187
+ GD+I + ++ + WW+GT+ +K G+FPSN+V+ +D + AG
Sbjct: 1022 TFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVR------------LKDSEGSGTAGK 1068
Query: 188 TSPIPSLGNVSET-ASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPLI 246
T + +++ AS + T P+++ + G + + +R + E +
Sbjct: 1069 TGSLGKKPEIAQVIASYTATGPEQLT-LAPGQL-----ILIRKKNPGGWWEGE------- 1115
Query: 247 LQSLGPKTQ---------------SVEITKTDTEGKIKAKEYCRTLFAYEGT--NEDELT 289
LQ+ G K Q + +IT T+ C+ + Y+ T N+DEL
Sbjct: 1116 LQARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELA 1175
Query: 290 FKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINELD 332
F +G+II++++KE + WW+GE+NG+ G+FP N+ ++D
Sbjct: 1176 FNKGQIINVLNKE--DPDWWKGEVNGQVGLFPSNYVKLTTDMD 1216
Score = 69.7 bits (169), Expect = 8e-12
Identities = 54/207 (26%), Positives = 89/207 (42%), Gaps = 48/207 (23%)
Query: 3 DYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRE-- 60
++I Y Y++ +LT + G++I KK + W G + + G+FP N+V+ E
Sbjct: 1006 EFIAMYTYESSEQGDLTFQQGDVILVTKK--DGDWWTGTVGDKAGVFPSNYVRLKDSEGS 1063
Query: 61 -TEFKDDSLPIKRERHGNVAS-----------------LVQRISTYGLPAGGIQPHPQTK 102
T K SL K E +AS L+++ + G G +Q + +
Sbjct: 1064 GTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKR 1123
Query: 103 NI------------------------KKKTKKRQCKV--LFEYIPQNEDELELKVGDIID 136
I K C+V +++Y QN+DEL G II+
Sbjct: 1124 QIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIIN 1183
Query: 137 INEEVEEGWWSGTLNNKLGLFPSNFVK 163
+ + + WW G +N ++GLFPSN+VK
Sbjct: 1184 VLNKEDPDWWKGEVNGQVGLFPSNYVK 1210
Score = 63.2 bits (152), Expect = 7e-10
Identities = 48/145 (33%), Positives = 69/145 (47%), Gaps = 16/145 (11%)
Query: 221 KEGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEG---KIKAKE----- 272
+E SVK + + E + L Q P +V+ + E I A+E
Sbjct: 684 REESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVV 743
Query: 273 YCRTLFAYEGTNEDELTFKEGEIIHLISK-----ETGEAGWWRGELNGKEGVFPDNFAVQ 327
Y R L+ +E + DE+T + G+I+ + + +TGE GW GEL GK G FP N+A +
Sbjct: 744 YYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEK 803
Query: 328 INELDKDFPKPKKP-PPPAKAPAPK 351
I E + P P KP APAPK
Sbjct: 804 IPE--NEVPAPVKPVTDSTSAPAPK 826
Score = 62.4 bits (150), Expect = 1e-09
Identities = 64/351 (18%), Positives = 137/351 (39%), Gaps = 39/351 (11%)
Query: 55 KEIKRETEFK--DDSLPIKRERHGNVASLVQRISTYGLPA-----GGIQPHPQTKNIKKK 107
+++KRE K D K+E + L + PA + P T + ++
Sbjct: 680 EKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQEN 739
Query: 108 TKKRQCKVLFEYIPQNEDELELKVGDII-------DINEEVEEGWWSGTLNNKLGLFPSN 160
K + L+ + ++ DE+ ++ GDI+ D ++ E GW G L K G FP+N
Sbjct: 740 VKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPAN 799
Query: 161 FVKELEVTDDGETHEAQDDSETVLAGPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIF 220
+ +++ + + DS + A + + ++ T+S T P + D
Sbjct: 800 YAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPN-----NWADFS 854
Query: 221 KEGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEG-----------KIK 269
+ + + + L + S G Q T G K++
Sbjct: 855 STWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVE 914
Query: 270 AKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQIN 329
+ + L+ + ++ L F + ++I ++ ++ WW GE+ G++G FP ++ I+
Sbjct: 915 GLQ-AQALYPWRAKKDNHLNFNKNDVITVLEQQD---MWWFGEVQGQKGWFPKSYVKLIS 970
Query: 330 -----ELDKDFPKPKKPPPPAKAPAPKPELIAAEKKYFSLKPEEKDEKSTL 375
D + P + +P + + + +++ ++ E E+ L
Sbjct: 971 GPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDL 1021
Score = 60.1 bits (144), Expect = 6e-09
Identities = 69/282 (24%), Positives = 121/282 (42%), Gaps = 31/282 (10%)
Query: 77 NVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDELELKVGDIID 136
+ L QR + A G P P +K + Q + L+ + + ++ L D+I
Sbjct: 883 SAGQLRQRSAFTPATATGSSPSPVLGQ-GEKVEGLQAQALYPWRAKKDNHLNFNKNDVIT 941
Query: 137 INEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGPTSPIPSLGN 196
+ E+ ++ WW G + + G FP ++VK + G + S ++ +G + SL
Sbjct: 942 VLEQ-QDMWWFGEVQGQKGWFPKSYVKLIS----GPIRK----STSMDSGSSESPASLKR 992
Query: 197 VSETASGSVTQPKKIRGIGF------GDI-FKEGSVKLRTRTSSSETEEKKPEKPLILQS 249
V+ A+ V ++ + GD+ F++G V L T+ +K + S
Sbjct: 993 VASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGDWWTGTVGDKAGVFPS 1052
Query: 250 LGPKTQSVEITKTDTEGKI----KAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGE 305
+ + E + T GK K E + + +Y T ++LT G++I + K G
Sbjct: 1053 NYVRLKDSE--GSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPG- 1109
Query: 306 AGWWRGEL--NGKE---GVFPDNFAVQINELDKDFPKPKKPP 342
GWW GEL GK+ G FP N+ V++ P +PP
Sbjct: 1110 -GWWEGELQARGKKRQIGWFPANY-VKLLSPGTSKITPTEPP 1149
Score = 48.5 bits (114), Expect = 2e-05
Identities = 27/92 (29%), Positives = 50/92 (54%), Gaps = 9/92 (9%)
Query: 277 LFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINELDKDFP 336
++ YE + + +LTF++G++I L++K+ G+ WW G + K GVFP N+ V++ + +
Sbjct: 1010 MYTYESSEQGDLTFQQGDVI-LVTKKDGD--WWTGTVGDKAGVFPSNY-VRLKDSEGSGT 1065
Query: 337 KPKKPPPPAKAPAPKPELIAAEKKYFSLKPEE 368
K + KPE+ Y + PE+
Sbjct: 1066 AGK-----TGSLGKKPEIAQVIASYTATGPEQ 1092
Score = 43.5 bits (101), Expect = 6e-04
Identities = 22/63 (34%), Positives = 36/63 (57%), Gaps = 6/63 (9%)
Query: 1 MVDYIVEYDYDAVHDDELTIRVGEIIR------NVKKLQEEGWLEGELNGRRGMFPDNFV 54
+V Y Y +++ DE+TI+ G+I+ + + E GWL GEL G+ G FP N+
Sbjct: 742 VVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYA 801
Query: 55 KEI 57
++I
Sbjct: 802 EKI 804
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 96.7 bits (239), Expect = 6e-20
Identities = 81/343 (23%), Positives = 155/343 (45%), Gaps = 66/343 (19%)
Query: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDS 67
Y + A D+ L ++I ++ Q++ W GE+ G++G FP ++VK I S
Sbjct: 922 YPWRAKKDNHLNFNKNDVITVLE--QQDMWWFGEVQGQKGWFPKSYVKLI---------S 970
Query: 68 LPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDEL 127
PI++ + S S + + +P + ++ Y + +L
Sbjct: 971 GPIRKSTSMDSGSSESPASLKRVASPAAKP---------VVSGEEFIAMYTYESSEQGDL 1021
Query: 128 ELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGP 187
+ GD+I + ++ + WW+GT+ +K G+FPSN+V+ +D + AG
Sbjct: 1022 TFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVR------------LKDSEGSGTAGK 1068
Query: 188 TSPIPSLGNVSET-ASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPLI 246
T + +++ AS + T P+++ + G + + +R + E +
Sbjct: 1069 TGSLGKKPEIAQVIASYTATGPEQLT-LAPGQL-----ILIRKKNPGGWWEGE------- 1115
Query: 247 LQSLGPKTQ---------------SVEITKTDTEGKIKAKEYCRTLFAYEGT--NEDELT 289
LQ+ G K Q + +IT T+ C+ + Y+ T N+DEL
Sbjct: 1116 LQARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELA 1175
Query: 290 FKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINELD 332
F +G+II++++KE + WW+GE+NG+ G+FP N+ ++D
Sbjct: 1176 FNKGQIINVLNKE--DPDWWKGEVNGQVGLFPSNYVKLTTDMD 1216
Score = 69.7 bits (169), Expect = 8e-12
Identities = 54/207 (26%), Positives = 89/207 (42%), Gaps = 48/207 (23%)
Query: 3 DYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRE-- 60
++I Y Y++ +LT + G++I KK + W G + + G+FP N+V+ E
Sbjct: 1006 EFIAMYTYESSEQGDLTFQQGDVILVTKK--DGDWWTGTVGDKAGVFPSNYVRLKDSEGS 1063
Query: 61 -TEFKDDSLPIKRERHGNVAS-----------------LVQRISTYGLPAGGIQPHPQTK 102
T K SL K E +AS L+++ + G G +Q + +
Sbjct: 1064 GTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKR 1123
Query: 103 NI------------------------KKKTKKRQCKV--LFEYIPQNEDELELKVGDIID 136
I K C+V +++Y QN+DEL G II+
Sbjct: 1124 QIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIIN 1183
Query: 137 INEEVEEGWWSGTLNNKLGLFPSNFVK 163
+ + + WW G +N ++GLFPSN+VK
Sbjct: 1184 VLNKEDPDWWKGEVNGQVGLFPSNYVK 1210
Score = 63.2 bits (152), Expect = 7e-10
Identities = 48/145 (33%), Positives = 69/145 (47%), Gaps = 16/145 (11%)
Query: 221 KEGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEG---KIKAKE----- 272
+E SVK + + E + L Q P +V+ + E I A+E
Sbjct: 684 REESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVV 743
Query: 273 YCRTLFAYEGTNEDELTFKEGEIIHLISK-----ETGEAGWWRGELNGKEGVFPDNFAVQ 327
Y R L+ +E + DE+T + G+I+ + + +TGE GW GEL GK G FP N+A +
Sbjct: 744 YYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEK 803
Query: 328 INELDKDFPKPKKP-PPPAKAPAPK 351
I E + P P KP APAPK
Sbjct: 804 IPE--NEVPAPVKPVTDSTSAPAPK 826
Score = 62.4 bits (150), Expect = 1e-09
Identities = 64/351 (18%), Positives = 137/351 (39%), Gaps = 39/351 (11%)
Query: 55 KEIKRETEFK--DDSLPIKRERHGNVASLVQRISTYGLPA-----GGIQPHPQTKNIKKK 107
+++KRE K D K+E + L + PA + P T + ++
Sbjct: 680 EKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQEN 739
Query: 108 TKKRQCKVLFEYIPQNEDELELKVGDII-------DINEEVEEGWWSGTLNNKLGLFPSN 160
K + L+ + ++ DE+ ++ GDI+ D ++ E GW G L K G FP+N
Sbjct: 740 VKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPAN 799
Query: 161 FVKELEVTDDGETHEAQDDSETVLAGPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIF 220
+ +++ + + DS + A + + ++ T+S T P + D
Sbjct: 800 YAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPN-----NWADFS 854
Query: 221 KEGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEG-----------KIK 269
+ + + + L + S G Q T G K++
Sbjct: 855 STWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVE 914
Query: 270 AKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQIN 329
+ + L+ + ++ L F + ++I ++ ++ WW GE+ G++G FP ++ I+
Sbjct: 915 GLQ-AQALYPWRAKKDNHLNFNKNDVITVLEQQD---MWWFGEVQGQKGWFPKSYVKLIS 970
Query: 330 -----ELDKDFPKPKKPPPPAKAPAPKPELIAAEKKYFSLKPEEKDEKSTL 375
D + P + +P + + + +++ ++ E E+ L
Sbjct: 971 GPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDL 1021
Score = 60.1 bits (144), Expect = 6e-09
Identities = 69/282 (24%), Positives = 121/282 (42%), Gaps = 31/282 (10%)
Query: 77 NVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDELELKVGDIID 136
+ L QR + A G P P +K + Q + L+ + + ++ L D+I
Sbjct: 883 SAGQLRQRSAFTPATATGSSPSPVLGQ-GEKVEGLQAQALYPWRAKKDNHLNFNKNDVIT 941
Query: 137 INEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGPTSPIPSLGN 196
+ E+ ++ WW G + + G FP ++VK + G + S ++ +G + SL
Sbjct: 942 VLEQ-QDMWWFGEVQGQKGWFPKSYVKLIS----GPIRK----STSMDSGSSESPASLKR 992
Query: 197 VSETASGSVTQPKKIRGIGF------GDI-FKEGSVKLRTRTSSSETEEKKPEKPLILQS 249
V+ A+ V ++ + GD+ F++G V L T+ +K + S
Sbjct: 993 VASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGDWWTGTVGDKAGVFPS 1052
Query: 250 LGPKTQSVEITKTDTEGKI----KAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGE 305
+ + E + T GK K E + + +Y T ++LT G++I + K G
Sbjct: 1053 NYVRLKDSE--GSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPG- 1109
Query: 306 AGWWRGEL--NGKE---GVFPDNFAVQINELDKDFPKPKKPP 342
GWW GEL GK+ G FP N+ V++ P +PP
Sbjct: 1110 -GWWEGELQARGKKRQIGWFPANY-VKLLSPGTSKITPTEPP 1149
Score = 54.3 bits (129), Expect = 3e-07
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 10/90 (11%)
Query: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVK---------EIK 58
YDY A +DDEL G+II NV ++ W +GE+NG+ G+FP N+VK +
Sbjct: 1164 YDYTAQNDDELAFNKGQII-NVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQQWC 1222
Query: 59 RETEFKDDSLPIKRERHGNVASLVQRISTY 88
+ D P +R+R G + L+ Y
Sbjct: 1223 SDLHLLDMLTPTERKRQGYIHELIVTEENY 1252
Score = 48.5 bits (114), Expect = 2e-05
Identities = 27/92 (29%), Positives = 50/92 (54%), Gaps = 9/92 (9%)
Query: 277 LFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINELDKDFP 336
++ YE + + +LTF++G++I L++K+ G+ WW G + K GVFP N+ V++ + +
Sbjct: 1010 MYTYESSEQGDLTFQQGDVI-LVTKKDGD--WWTGTVGDKAGVFPSNY-VRLKDSEGSGT 1065
Query: 337 KPKKPPPPAKAPAPKPELIAAEKKYFSLKPEE 368
K + KPE+ Y + PE+
Sbjct: 1066 AGK-----TGSLGKKPEIAQVIASYTATGPEQ 1092
Score = 43.5 bits (101), Expect = 6e-04
Identities = 22/63 (34%), Positives = 36/63 (57%), Gaps = 6/63 (9%)
Query: 1 MVDYIVEYDYDAVHDDELTIRVGEIIR------NVKKLQEEGWLEGELNGRRGMFPDNFV 54
+V Y Y +++ DE+TI+ G+I+ + + E GWL GEL G+ G FP N+
Sbjct: 742 VVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYA 801
Query: 55 KEI 57
++I
Sbjct: 802 EKI 804
>gi|242117948 SH3 domain-containing protein C1orf113 isoform 2 [Homo
sapiens]
Length = 645
Score = 94.4 bits (233), Expect = 3e-19
Identities = 104/424 (24%), Positives = 167/424 (39%), Gaps = 108/424 (25%)
Query: 139 EEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGPTSPIPSLGNVS 198
+E+E+GWW G N +LG FPSNFV+ L+ +GP PSLGN
Sbjct: 3 KEIEDGWWLGKKNGQLGAFPSNFVELLD------------------SGP----PSLGNPD 40
Query: 199 -ETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQSV 257
+ S +P K+ + + P LQ+
Sbjct: 41 MPSVSPGPQRPPKLSSLAYDS------------------------PPDYLQT-------- 68
Query: 258 EITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKE 317
+ E R LF Y+ DEL + G+++ ++SK T + GWW GE G+
Sbjct: 69 ----------VSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR 118
Query: 318 GVFPDNFAVQINELDKDFPKPKKPPPPAKAPAPKPELIAAEKKYFSLKPEEKDEKSTLEQ 377
GVFPDNF + PPPP K P+ ++++ E +P++ K++L
Sbjct: 119 GVFPDNFVL--------------PPPPIKKLVPR-KVVSRESAPIK-EPKKLMPKTSLPT 162
Query: 378 KPSKPAAPQVPPKKPT--PPTKASNLL-----------RSSGTVYPKRPEKPVPPPPPIA 424
A P K T P++ S L +S G+ +P R P
Sbjct: 163 VKKLATATTGPSKAKTSRTPSRDSQKLTSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQ-R 221
Query: 425 KINGEVSSISSKFETEPVSKLKL-DSEQLPLRPKSVDFDSLTVRTSKETDVVNFDDIASS 483
++ + SS + V + + D P RP + + +SK+ D + S
Sbjct: 222 SVSSQEEEHSSPVKAPSVKRTPMPDKTATPERPPAPE----NAPSSKKIPAP--DKVPSP 275
Query: 484 ENLLHLTANRPKMPGRRLPGRFNGGHSPTHSPEKILKLPKEEDSANL-KPSELKKDTCYS 542
E L L ++ +PG G+ +PEK++ ED A++ + S + ++T
Sbjct: 276 EKTLTL-GDKASIPGNSTSGKI-PAPDKVPTPEKMV---TPEDKASIPENSIIPEETLTV 330
Query: 543 PKPS 546
KPS
Sbjct: 331 DKPS 334
Score = 70.5 bits (171), Expect = 5e-12
Identities = 103/454 (22%), Positives = 167/454 (36%), Gaps = 104/454 (22%)
Query: 34 EEGWLEGELNGRRGMFPDNFVKEIKRETEFKDD----SLPIKRERHGNVASLVQRISTYG 89
E+GW G+ NG+ G FP NFV+ + + S+ +R ++SL Y
Sbjct: 6 EDGWWLGKKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSL-----AYD 60
Query: 90 LPAGGIQ--PHPQTKNIKKKTKKRQCKVLFEYIPQNEDELELKVGDIIDINEEVEE--GW 145
P +Q HP+ +VLF+Y P+ DEL L+ GD++ + + E GW
Sbjct: 61 SPPDYLQTVSHPEV-----------YRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGW 109
Query: 146 WSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGPTSPIPSL--GNVSETASG 203
W G + G+FP NFV P PI L V S
Sbjct: 110 WEGECQGRRGVFPDNFVL-----------------------PPPPIKKLVPRKVVSRESA 146
Query: 204 SVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTD 263
+ +PK KL +TS K L + GP T +
Sbjct: 147 PIKEPK----------------KLMPKTSLPTV------KKLATATTGPSKAKTSRTPSR 184
Query: 264 TEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDN 323
K+ +++ G N F+ G H K + + ++ +E
Sbjct: 185 DSQKLTSRD--------SGPNGG---FQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSP 233
Query: 324 F---AVQINELDKDFPKPKKPPPPAKAPA----PKPELIAAEKKYFSLKPEEKDEKSTLE 376
+V+ + P++PP P AP+ P P+ + + +K +L + ++
Sbjct: 234 VKAPSVKRTPMPDKTATPERPPAPENAPSSKKIPAPDKVPSPEKTLTLGDKASIPGNSTS 293
Query: 377 QKPSKPAAPQVPPKKPTPPTKAS---NLLRSSGTVYPKRP----------EKPVPPPPPI 423
K P P K TP KAS N + T+ +P E P PP+
Sbjct: 294 GKIPAPDKVPTPEKMVTPEDKASIPENSIIPEETLTVDKPSTPERVFSVEESPALEAPPM 353
Query: 424 AKI-NGEVSSISSKFET-EPVSKLKLDSEQLPLR 455
K+ N +++ + + T E V +L E++ R
Sbjct: 354 DKVPNPKMAPLGDEAPTLEKVLTPELSEEEVSTR 387
Score = 57.4 bits (137), Expect = 4e-08
Identities = 31/78 (39%), Positives = 44/78 (56%), Gaps = 7/78 (8%)
Query: 4 YIVEYDYDAVHDDELTIRVGEIIRNVKKLQEE-GWLEGELNGRRGMFPDNFV------KE 56
Y V +DY DEL +R G++++ + K E+ GW EGE GRRG+FPDNFV K+
Sbjct: 75 YRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPPPPIKK 134
Query: 57 IKRETEFKDDSLPIKRER 74
+ +S PIK +
Sbjct: 135 LVPRKVVSRESAPIKEPK 152
Score = 29.6 bits (65), Expect = 8.9
Identities = 23/91 (25%), Positives = 42/91 (46%), Gaps = 9/91 (9%)
Query: 333 KDFPKPKKPPPPAKAPAPKP---ELIAAEKKYFSLKPEEKDEKSTLEQKP-SKPAAPQVP 388
K+ P ++ +AP P+P E E K ++ + ++ L+ P S+PA
Sbjct: 410 KEDPSSQEEAHTPEAPPPQPPSSERCLGEMKCTLVRGDSSPRQAELKSGPASRPAL---- 465
Query: 389 PKKPTPPTKASNLLRSSGTVYPKRPEKPVPP 419
+KP P +A+ L + + + PE+ PP
Sbjct: 466 -EKPHPHEEATTLPEEAPSNDERTPEEEAPP 495
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 90.5 bits (223), Expect = 4e-18
Identities = 90/329 (27%), Positives = 139/329 (42%), Gaps = 55/329 (16%)
Query: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFK 64
+V +D+ A D+L + GEI+ ++K+ + W G + G+FP N+VK I
Sbjct: 442 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDTD-WYRGNCRNQIGIFPANYVKVI------- 493
Query: 65 DDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNE 124
+P GG + K +C FEYI + +
Sbjct: 494 -----------------------IDIPEGGNGKRECVSS--HCVKGSRCVARFEYIGEQK 528
Query: 125 DELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVL 184
DEL G+II + E V E W G + + G+FP NFV+ +E D T A S V
Sbjct: 529 DELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVE---DYPTSGANVLSTKVP 585
Query: 185 -------AGPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDI-FKEGS-VKLRTRTSSSE 235
+G S + SL A S T D+ FK G +++ R S
Sbjct: 586 LKTKKEDSGSNSQVNSLPAEWCEALHSFTAETS------DDLSFKRGDRIQILERLDSDW 639
Query: 236 TEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEI 295
+ ++ I ++ + E K+ K ++ + L+ + G NEDEL+FK G+I
Sbjct: 640 CRGRLQDREGIFPAVFVRPCPAE-AKSMLAIVPKGRK-AKALYDFRGENEDELSFKAGDI 697
Query: 296 IHLISKETGEAGWWRGELNGKEGVFPDNF 324
I E+ + W GEL GK G+FP N+
Sbjct: 698 I--TELESVDDDWMSGELMGKSGIFPKNY 724
Score = 76.6 bits (187), Expect = 6e-14
Identities = 61/218 (27%), Positives = 97/218 (44%), Gaps = 58/218 (26%)
Query: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEI------- 57
+ ++Y DEL+ GEII +K+ E W GE+ GR G+FP NFV+ +
Sbjct: 518 VARFEYIGEQKDELSFSEGEIII-LKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSG 576
Query: 58 ------------KRE----------------------TEFKDDSLPIKRERHGNVASLVQ 83
K+E T D L KR G+ +++
Sbjct: 577 ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKR---GDRIQILE 633
Query: 84 RISTYG-----------LPAGGIQPHP-QTKNIKKKTKK-RQCKVLFEYIPQNEDELELK 130
R+ + PA ++P P + K++ K R+ K L+++ +NEDEL K
Sbjct: 634 RLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFK 693
Query: 131 VGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVT 168
GDII E V++ W SG L K G+FP N+++ L+++
Sbjct: 694 AGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQIS 731
Score = 50.8 bits (120), Expect = 4e-06
Identities = 26/57 (45%), Positives = 33/57 (57%), Gaps = 2/57 (3%)
Query: 274 CRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINE 330
C F Y G +DEL+F EGEII I KE W RGE+ G+ G+FP NF + +
Sbjct: 517 CVARFEYIGEQKDELSFSEGEII--ILKEYVNEEWARGEVRGRTGIFPLNFVEPVED 571
Score = 34.7 bits (78), Expect = 0.28
Identities = 15/46 (32%), Positives = 26/46 (56%), Gaps = 2/46 (4%)
Query: 286 DELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINEL 331
D+L GEI++L+ K + W+RG + G+FP N+ I ++
Sbjct: 453 DDLNLTSGEIVYLLEKI--DTDWYRGNCRNQIGIFPANYVKVIIDI 496
Score = 30.4 bits (67), Expect = 5.2
Identities = 26/85 (30%), Positives = 30/85 (35%), Gaps = 13/85 (15%)
Query: 340 KPPPPAKAPAPKPELIAAEKKYFSLKPEEKDEKSTLEQKPSKPAAPQVPPKKPTPPTKAS 399
KP P K P P LI S+ PE E S P P+ P
Sbjct: 100 KPELPKK---PNPGLIR------SVNPEIPGRGPLAESSDSGKKVPTPAPR----PLLLK 146
Query: 400 NLLRSSGTVYPKRPEKPVPPPPPIA 424
+ S YP P KPV PP +A
Sbjct: 147 KSVSSENPTYPSAPLKPVTVPPRLA 171
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 90.5 bits (223), Expect = 4e-18
Identities = 90/329 (27%), Positives = 139/329 (42%), Gaps = 55/329 (16%)
Query: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFK 64
+V +D+ A D+L + GEI+ ++K+ + W G + G+FP N+VK I
Sbjct: 478 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDTD-WYRGNCRNQIGIFPANYVKVI------- 529
Query: 65 DDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNE 124
+P GG + K +C FEYI + +
Sbjct: 530 -----------------------IDIPEGGNGKRECVSS--HCVKGSRCVARFEYIGEQK 564
Query: 125 DELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVL 184
DEL G+II + E V E W G + + G+FP NFV+ +E D T A S V
Sbjct: 565 DELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVE---DYPTSGANVLSTKVP 621
Query: 185 -------AGPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDI-FKEGS-VKLRTRTSSSE 235
+G S + SL A S T D+ FK G +++ R S
Sbjct: 622 LKTKKEDSGSNSQVNSLPAEWCEALHSFTAETS------DDLSFKRGDRIQILERLDSDW 675
Query: 236 TEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEI 295
+ ++ I ++ + E K+ K ++ + L+ + G NEDEL+FK G+I
Sbjct: 676 CRGRLQDREGIFPAVFVRPCPAE-AKSMLAIVPKGRK-AKALYDFRGENEDELSFKAGDI 733
Query: 296 IHLISKETGEAGWWRGELNGKEGVFPDNF 324
I E+ + W GEL GK G+FP N+
Sbjct: 734 I--TELESVDDDWMSGELMGKSGIFPKNY 760
Score = 76.6 bits (187), Expect = 6e-14
Identities = 61/218 (27%), Positives = 97/218 (44%), Gaps = 58/218 (26%)
Query: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEI------- 57
+ ++Y DEL+ GEII +K+ E W GE+ GR G+FP NFV+ +
Sbjct: 554 VARFEYIGEQKDELSFSEGEIII-LKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSG 612
Query: 58 ------------KRE----------------------TEFKDDSLPIKRERHGNVASLVQ 83
K+E T D L KR G+ +++
Sbjct: 613 ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKR---GDRIQILE 669
Query: 84 RISTYG-----------LPAGGIQPHP-QTKNIKKKTKK-RQCKVLFEYIPQNEDELELK 130
R+ + PA ++P P + K++ K R+ K L+++ +NEDEL K
Sbjct: 670 RLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFK 729
Query: 131 VGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVT 168
GDII E V++ W SG L K G+FP N+++ L+++
Sbjct: 730 AGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQIS 767
Score = 50.8 bits (120), Expect = 4e-06
Identities = 26/57 (45%), Positives = 33/57 (57%), Gaps = 2/57 (3%)
Query: 274 CRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINE 330
C F Y G +DEL+F EGEII I KE W RGE+ G+ G+FP NF + +
Sbjct: 553 CVARFEYIGEQKDELSFSEGEII--ILKEYVNEEWARGEVRGRTGIFPLNFVEPVED 607
Score = 34.7 bits (78), Expect = 0.28
Identities = 15/46 (32%), Positives = 26/46 (56%), Gaps = 2/46 (4%)
Query: 286 DELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINEL 331
D+L GEI++L+ K + W+RG + G+FP N+ I ++
Sbjct: 489 DDLNLTSGEIVYLLEKI--DTDWYRGNCRNQIGIFPANYVKVIIDI 532
Score = 30.4 bits (67), Expect = 5.2
Identities = 26/85 (30%), Positives = 30/85 (35%), Gaps = 13/85 (15%)
Query: 340 KPPPPAKAPAPKPELIAAEKKYFSLKPEEKDEKSTLEQKPSKPAAPQVPPKKPTPPTKAS 399
KP P K P P LI S+ PE E S P P+ P
Sbjct: 100 KPELPKK---PNPGLIR------SVNPEIPGRGPLAESSDSGKKVPTPAPR----PLLLK 146
Query: 400 NLLRSSGTVYPKRPEKPVPPPPPIA 424
+ S YP P KPV PP +A
Sbjct: 147 KSVSSENPTYPSAPLKPVTVPPRLA 171
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 90.5 bits (223), Expect = 4e-18
Identities = 90/329 (27%), Positives = 139/329 (42%), Gaps = 55/329 (16%)
Query: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFK 64
+V +D+ A D+L + GEI+ ++K+ + W G + G+FP N+VK I
Sbjct: 501 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDTD-WYRGNCRNQIGIFPANYVKVI------- 552
Query: 65 DDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNE 124
+P GG + K +C FEYI + +
Sbjct: 553 -----------------------IDIPEGGNGKRECVSS--HCVKGSRCVARFEYIGEQK 587
Query: 125 DELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVL 184
DEL G+II + E V E W G + + G+FP NFV+ +E D T A S V
Sbjct: 588 DELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVE---DYPTSGANVLSTKVP 644
Query: 185 -------AGPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDI-FKEGS-VKLRTRTSSSE 235
+G S + SL A S T D+ FK G +++ R S
Sbjct: 645 LKTKKEDSGSNSQVNSLPAEWCEALHSFTAETS------DDLSFKRGDRIQILERLDSDW 698
Query: 236 TEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEI 295
+ ++ I ++ + E K+ K ++ + L+ + G NEDEL+FK G+I
Sbjct: 699 CRGRLQDREGIFPAVFVRPCPAE-AKSMLAIVPKGRK-AKALYDFRGENEDELSFKAGDI 756
Query: 296 IHLISKETGEAGWWRGELNGKEGVFPDNF 324
I E+ + W GEL GK G+FP N+
Sbjct: 757 I--TELESVDDDWMSGELMGKSGIFPKNY 783
Score = 76.6 bits (187), Expect = 6e-14
Identities = 61/218 (27%), Positives = 97/218 (44%), Gaps = 58/218 (26%)
Query: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEI------- 57
+ ++Y DEL+ GEII +K+ E W GE+ GR G+FP NFV+ +
Sbjct: 577 VARFEYIGEQKDELSFSEGEIII-LKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSG 635
Query: 58 ------------KRE----------------------TEFKDDSLPIKRERHGNVASLVQ 83
K+E T D L KR G+ +++
Sbjct: 636 ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKR---GDRIQILE 692
Query: 84 RISTYG-----------LPAGGIQPHP-QTKNIKKKTKK-RQCKVLFEYIPQNEDELELK 130
R+ + PA ++P P + K++ K R+ K L+++ +NEDEL K
Sbjct: 693 RLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFK 752
Query: 131 VGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVT 168
GDII E V++ W SG L K G+FP N+++ L+++
Sbjct: 753 AGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQIS 790
Score = 50.8 bits (120), Expect = 4e-06
Identities = 26/57 (45%), Positives = 33/57 (57%), Gaps = 2/57 (3%)
Query: 274 CRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINE 330
C F Y G +DEL+F EGEII I KE W RGE+ G+ G+FP NF + +
Sbjct: 576 CVARFEYIGEQKDELSFSEGEII--ILKEYVNEEWARGEVRGRTGIFPLNFVEPVED 630
Score = 34.7 bits (78), Expect = 0.28
Identities = 15/46 (32%), Positives = 26/46 (56%), Gaps = 2/46 (4%)
Query: 286 DELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINEL 331
D+L GEI++L+ K + W+RG + G+FP N+ I ++
Sbjct: 512 DDLNLTSGEIVYLLEKI--DTDWYRGNCRNQIGIFPANYVKVIIDI 555
Score = 30.4 bits (67), Expect = 5.2
Identities = 26/85 (30%), Positives = 30/85 (35%), Gaps = 13/85 (15%)
Query: 340 KPPPPAKAPAPKPELIAAEKKYFSLKPEEKDEKSTLEQKPSKPAAPQVPPKKPTPPTKAS 399
KP P K P P LI S+ PE E S P P+ P
Sbjct: 100 KPELPKK---PNPGLIR------SVNPEIPGRGPLAESSDSGKKVPTPAPR----PLLLK 146
Query: 400 NLLRSSGTVYPKRPEKPVPPPPPIA 424
+ S YP P KPV PP +A
Sbjct: 147 KSVSSENPTYPSAPLKPVTVPPRLA 171
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 87.0 bits (214), Expect = 5e-17
Identities = 77/336 (22%), Positives = 139/336 (41%), Gaps = 69/336 (20%)
Query: 10 YDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDSLP 69
+ A D+ L +II ++ Q+E W GE++G RG FP ++VK I
Sbjct: 882 WTAKKDNHLNFSKHDIITVLE--QQENWWFGEVHGGRGWFPKSYVKIIPGSE-------- 931
Query: 70 IKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDELEL 129
+KRE + + V + T + G + L+ Y +L
Sbjct: 932 VKREEPEALYAAVNKKPTSAAYSVG----------------EEYIALYPYSSVEPGDLTF 975
Query: 130 KVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGPTS 189
G+ I + ++ E WW+G++ ++ G+FPSN+VK + G ++ G ++
Sbjct: 976 TEGEEILVTQKDGE-WWTGSIGDRSGIFPSNYVKPKDQESFGSASKS---------GASN 1025
Query: 190 PIPSLGNVSET--ASGS-----------VTQPKKIRGIGFGDIFKEGSVKLRTRTSSSET 236
P + V+ ASGS + K G G++ G + + +S
Sbjct: 1026 KKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHV 1085
Query: 237 EEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEII 296
+ P + P Q + ++ Y NEDEL+F +G++I
Sbjct: 1086 KLLGPSSERATPAFHPVCQVI------------------AMYDYAANNEDELSFSKGQLI 1127
Query: 297 HLISKETGEAGWWRGELNGKEGVFPDNFAVQINELD 332
++++K+ + WW+GE+NG G+FP N+ + D
Sbjct: 1128 NVMNKD--DPDWWQGEINGVTGLFPSNYVKMTTDSD 1161
Score = 73.2 bits (178), Expect = 7e-13
Identities = 57/210 (27%), Positives = 83/210 (39%), Gaps = 43/210 (20%)
Query: 3 DYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETE 62
+YI Y Y +V +LT GE I +K E W G + R G+FP N+VK K +
Sbjct: 958 EYIALYPYSSVEPGDLTFTEGEEILVTQKDGE--WWTGSIGDRSGIFPSNYVKP-KDQES 1014
Query: 63 FKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKT------------KK 110
F S + +A + G + P +KK T KK
Sbjct: 1015 FGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKK 1074
Query: 111 RQ--------------------------CKVL--FEYIPQNEDELELKVGDIIDINEEVE 142
RQ C+V+ ++Y NEDEL G +I++ + +
Sbjct: 1075 RQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDD 1134
Query: 143 EGWWSGTLNNKLGLFPSNFVKELEVTDDGE 172
WW G +N GLFPSN+VK +D +
Sbjct: 1135 PDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1164
Score = 65.5 bits (158), Expect = 1e-10
Identities = 77/361 (21%), Positives = 149/361 (41%), Gaps = 61/361 (16%)
Query: 30 KKLQEEGWLEGELNGRRGMFPDNFVKEIK-RETEFKDDSLPIKRERHGNVASLVQRISTY 88
KKL++E + + G+ ++ +N KE + ++ +++ K + A QR
Sbjct: 659 KKLEDEAARKAK-QGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQR---- 713
Query: 89 GLPAGGIQPHPQTKNIKKKTKKRQC-------KVLFEYIPQNEDELELKVGDIIDINEEV 141
+K + KKR+ + L+ + +N DE+ GDII ++E+
Sbjct: 714 ----------KDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKT 763
Query: 142 --EEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGPTSPIPSLGNVSE 199
E GW G+ G FP N+V+++ ++ +E + L PT + + SE
Sbjct: 764 VGEPGWLYGSFQGNFGWFPCNYVEKMPSSE----NEKAVSPKKALLPPTVSLSATSTSSE 819
Query: 200 TASGSVTQPKKI---RGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQS 256
S + QP + + + F ++ +V + S+ T P + G Q
Sbjct: 820 PLSSN--QPASVTDYQNVSFSNL----TVNTSWQKKSAFTRTVSPGSVSPIHGQG---QV 870
Query: 257 VEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGK 316
VE +KA+ C ++ ++ L F + +II ++ + + WW GE++G
Sbjct: 871 VE--------NLKAQALC----SWTAKKDNHLNFSKHDIITVLEQ---QENWWFGEVHGG 915
Query: 317 EGVFPDNFAVQI--NELDKDFPKPKKPPPPAKAPAPKPELIAAEKKYFSLKPEEKDEKST 374
G FP ++ I +E+ ++ P+ K P + ++Y +L P E
Sbjct: 916 RGWFPKSYVKIIPGSEVKREEPEALYAAVNKK---PTSAAYSVGEEYIALYPYSSVEPGD 972
Query: 375 L 375
L
Sbjct: 973 L 973
Score = 56.6 bits (135), Expect = 7e-08
Identities = 32/93 (34%), Positives = 49/93 (52%), Gaps = 10/93 (10%)
Query: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVK--------- 55
I YDY A ++DEL+ G++I NV + W +GE+NG G+FP N+VK
Sbjct: 1106 IAMYDYAANNEDELSFSKGQLI-NVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1164
Query: 56 EIKRETEFKDDSLPIKRERHGNVASLVQRISTY 88
+ + + D PI+R+R G + L+Q Y
Sbjct: 1165 QWCADLQTLDTMQPIERKRQGYIHELIQTEERY 1197
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 87.0 bits (214), Expect = 5e-17
Identities = 77/336 (22%), Positives = 139/336 (41%), Gaps = 69/336 (20%)
Query: 10 YDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDSLP 69
+ A D+ L +II ++ Q+E W GE++G RG FP ++VK I
Sbjct: 909 WTAKKDNHLNFSKHDIITVLE--QQENWWFGEVHGGRGWFPKSYVKIIPGSE-------- 958
Query: 70 IKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDELEL 129
+KRE + + V + T + G + L+ Y +L
Sbjct: 959 VKREEPEALYAAVNKKPTSAAYSVG----------------EEYIALYPYSSVEPGDLTF 1002
Query: 130 KVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGPTS 189
G+ I + ++ E WW+G++ ++ G+FPSN+VK + G ++ G ++
Sbjct: 1003 TEGEEILVTQKDGE-WWTGSIGDRSGIFPSNYVKPKDQESFGSASKS---------GASN 1052
Query: 190 PIPSLGNVSET--ASGS-----------VTQPKKIRGIGFGDIFKEGSVKLRTRTSSSET 236
P + V+ ASGS + K G G++ G + + +S
Sbjct: 1053 KKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHV 1112
Query: 237 EEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEII 296
+ P + P Q + ++ Y NEDEL+F +G++I
Sbjct: 1113 KLLGPSSERATPAFHPVCQVI------------------AMYDYAANNEDELSFSKGQLI 1154
Query: 297 HLISKETGEAGWWRGELNGKEGVFPDNFAVQINELD 332
++++K+ + WW+GE+NG G+FP N+ + D
Sbjct: 1155 NVMNKD--DPDWWQGEINGVTGLFPSNYVKMTTDSD 1188
Score = 73.2 bits (178), Expect = 7e-13
Identities = 57/210 (27%), Positives = 83/210 (39%), Gaps = 43/210 (20%)
Query: 3 DYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETE 62
+YI Y Y +V +LT GE I +K E W G + R G+FP N+VK K +
Sbjct: 985 EYIALYPYSSVEPGDLTFTEGEEILVTQKDGE--WWTGSIGDRSGIFPSNYVKP-KDQES 1041
Query: 63 FKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKT------------KK 110
F S + +A + G + P +KK T KK
Sbjct: 1042 FGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKK 1101
Query: 111 RQ--------------------------CKVL--FEYIPQNEDELELKVGDIIDINEEVE 142
RQ C+V+ ++Y NEDEL G +I++ + +
Sbjct: 1102 RQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDD 1161
Query: 143 EGWWSGTLNNKLGLFPSNFVKELEVTDDGE 172
WW G +N GLFPSN+VK +D +
Sbjct: 1162 PDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1191
Score = 65.5 bits (158), Expect = 1e-10
Identities = 77/361 (21%), Positives = 149/361 (41%), Gaps = 61/361 (16%)
Query: 30 KKLQEEGWLEGELNGRRGMFPDNFVKEIK-RETEFKDDSLPIKRERHGNVASLVQRISTY 88
KKL++E + + G+ ++ +N KE + ++ +++ K + A QR
Sbjct: 686 KKLEDEAARKAK-QGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQR---- 740
Query: 89 GLPAGGIQPHPQTKNIKKKTKKRQC-------KVLFEYIPQNEDELELKVGDIIDINEEV 141
+K + KKR+ + L+ + +N DE+ GDII ++E+
Sbjct: 741 ----------KDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKT 790
Query: 142 --EEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGPTSPIPSLGNVSE 199
E GW G+ G FP N+V+++ ++ +E + L PT + + SE
Sbjct: 791 VGEPGWLYGSFQGNFGWFPCNYVEKMPSSE----NEKAVSPKKALLPPTVSLSATSTSSE 846
Query: 200 TASGSVTQPKKI---RGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQS 256
S + QP + + + F ++ +V + S+ T P + G Q
Sbjct: 847 PLSSN--QPASVTDYQNVSFSNL----TVNTSWQKKSAFTRTVSPGSVSPIHGQG---QV 897
Query: 257 VEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGK 316
VE +KA+ C ++ ++ L F + +II ++ + + WW GE++G
Sbjct: 898 VE--------NLKAQALC----SWTAKKDNHLNFSKHDIITVLEQ---QENWWFGEVHGG 942
Query: 317 EGVFPDNFAVQI--NELDKDFPKPKKPPPPAKAPAPKPELIAAEKKYFSLKPEEKDEKST 374
G FP ++ I +E+ ++ P+ K P + ++Y +L P E
Sbjct: 943 RGWFPKSYVKIIPGSEVKREEPEALYAAVNKK---PTSAAYSVGEEYIALYPYSSVEPGD 999
Query: 375 L 375
L
Sbjct: 1000 L 1000
Score = 56.6 bits (135), Expect = 7e-08
Identities = 32/93 (34%), Positives = 49/93 (52%), Gaps = 10/93 (10%)
Query: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVK--------- 55
I YDY A ++DEL+ G++I NV + W +GE+NG G+FP N+VK
Sbjct: 1133 IAMYDYAANNEDELSFSKGQLI-NVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1191
Query: 56 EIKRETEFKDDSLPIKRERHGNVASLVQRISTY 88
+ + + D PI+R+R G + L+Q Y
Sbjct: 1192 QWCADLQTLDTMQPIERKRQGYIHELIQTEERY 1224
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 87.0 bits (214), Expect = 5e-17
Identities = 77/336 (22%), Positives = 139/336 (41%), Gaps = 69/336 (20%)
Query: 10 YDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDSLP 69
+ A D+ L +II ++ Q+E W GE++G RG FP ++VK I
Sbjct: 909 WTAKKDNHLNFSKHDIITVLE--QQENWWFGEVHGGRGWFPKSYVKIIPGSE-------- 958
Query: 70 IKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDELEL 129
+KRE + + V + T + G + L+ Y +L
Sbjct: 959 VKREEPEALYAAVNKKPTSAAYSVG----------------EEYIALYPYSSVEPGDLTF 1002
Query: 130 KVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGPTS 189
G+ I + ++ E WW+G++ ++ G+FPSN+VK + G ++ G ++
Sbjct: 1003 TEGEEILVTQKDGE-WWTGSIGDRSGIFPSNYVKPKDQESFGSASKS---------GASN 1052
Query: 190 PIPSLGNVSET--ASGS-----------VTQPKKIRGIGFGDIFKEGSVKLRTRTSSSET 236
P + V+ ASGS + K G G++ G + + +S
Sbjct: 1053 KKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHV 1112
Query: 237 EEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEII 296
+ P + P Q + ++ Y NEDEL+F +G++I
Sbjct: 1113 KLLGPSSERATPAFHPVCQVI------------------AMYDYAANNEDELSFSKGQLI 1154
Query: 297 HLISKETGEAGWWRGELNGKEGVFPDNFAVQINELD 332
++++K+ + WW+GE+NG G+FP N+ + D
Sbjct: 1155 NVMNKD--DPDWWQGEINGVTGLFPSNYVKMTTDSD 1188
Score = 73.2 bits (178), Expect = 7e-13
Identities = 57/210 (27%), Positives = 83/210 (39%), Gaps = 43/210 (20%)
Query: 3 DYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETE 62
+YI Y Y +V +LT GE I +K E W G + R G+FP N+VK K +
Sbjct: 985 EYIALYPYSSVEPGDLTFTEGEEILVTQKDGE--WWTGSIGDRSGIFPSNYVKP-KDQES 1041
Query: 63 FKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKT------------KK 110
F S + +A + G + P +KK T KK
Sbjct: 1042 FGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKK 1101
Query: 111 RQ--------------------------CKVL--FEYIPQNEDELELKVGDIIDINEEVE 142
RQ C+V+ ++Y NEDEL G +I++ + +
Sbjct: 1102 RQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDD 1161
Query: 143 EGWWSGTLNNKLGLFPSNFVKELEVTDDGE 172
WW G +N GLFPSN+VK +D +
Sbjct: 1162 PDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1191
Score = 65.5 bits (158), Expect = 1e-10
Identities = 77/361 (21%), Positives = 149/361 (41%), Gaps = 61/361 (16%)
Query: 30 KKLQEEGWLEGELNGRRGMFPDNFVKEIK-RETEFKDDSLPIKRERHGNVASLVQRISTY 88
KKL++E + + G+ ++ +N KE + ++ +++ K + A QR
Sbjct: 686 KKLEDEAARKAK-QGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQR---- 740
Query: 89 GLPAGGIQPHPQTKNIKKKTKKRQC-------KVLFEYIPQNEDELELKVGDIIDINEEV 141
+K + KKR+ + L+ + +N DE+ GDII ++E+
Sbjct: 741 ----------KDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKT 790
Query: 142 --EEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGPTSPIPSLGNVSE 199
E GW G+ G FP N+V+++ ++ +E + L PT + + SE
Sbjct: 791 VGEPGWLYGSFQGNFGWFPCNYVEKMPSSE----NEKAVSPKKALLPPTVSLSATSTSSE 846
Query: 200 TASGSVTQPKKI---RGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQS 256
S + QP + + + F ++ +V + S+ T P + G Q
Sbjct: 847 PLSSN--QPASVTDYQNVSFSNL----TVNTSWQKKSAFTRTVSPGSVSPIHGQG---QV 897
Query: 257 VEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGK 316
VE +KA+ C ++ ++ L F + +II ++ + + WW GE++G
Sbjct: 898 VE--------NLKAQALC----SWTAKKDNHLNFSKHDIITVLEQ---QENWWFGEVHGG 942
Query: 317 EGVFPDNFAVQI--NELDKDFPKPKKPPPPAKAPAPKPELIAAEKKYFSLKPEEKDEKST 374
G FP ++ I +E+ ++ P+ K P + ++Y +L P E
Sbjct: 943 RGWFPKSYVKIIPGSEVKREEPEALYAAVNKK---PTSAAYSVGEEYIALYPYSSVEPGD 999
Query: 375 L 375
L
Sbjct: 1000 L 1000
Score = 56.6 bits (135), Expect = 7e-08
Identities = 32/93 (34%), Positives = 49/93 (52%), Gaps = 10/93 (10%)
Query: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVK--------- 55
I YDY A ++DEL+ G++I NV + W +GE+NG G+FP N+VK
Sbjct: 1133 IAMYDYAANNEDELSFSKGQLI-NVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1191
Query: 56 EIKRETEFKDDSLPIKRERHGNVASLVQRISTY 88
+ + + D PI+R+R G + L+Q Y
Sbjct: 1192 QWCADLQTLDTMQPIERKRQGYIHELIQTEERY 1224
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 83.2 bits (204), Expect = 7e-16
Identities = 53/165 (32%), Positives = 96/165 (58%), Gaps = 12/165 (7%)
Query: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNG--RRGMFPDNFVKEIKRETE 62
I +Y+++A + EL++R G+ + +K++ ++ W EG++ G R+G+FP ++V+ +K+ T+
Sbjct: 336 IAKYNFNADTNVELSLRKGDRVILLKRV-DQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 394
Query: 63 FKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQ 122
+D P H + + +S+ P + H +NI+ + Q L+ Y P+
Sbjct: 395 GAED-YPDPPIPHSYSSDRIHSLSS-NKPQRPVFTH---ENIQGGGEPFQA--LYNYTPR 447
Query: 123 NEDELELKVGDIIDINEEVEEGWWSGTLNNK--LGLFPSNFVKEL 165
NEDELEL+ D+ID+ E+ ++GW+ GT G FP N+VK L
Sbjct: 448 NEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492
Score = 55.8 bits (133), Expect = 1e-07
Identities = 65/325 (20%), Positives = 128/325 (39%), Gaps = 100/325 (30%)
Query: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDS 67
YD+ A EL+ + G+ + ++K+ ++ W EGE +GR G+FP ++V+++ E +
Sbjct: 264 YDFKAQTSKELSFKKGDTVYILRKI-DQNWYEGEHHGRVGIFPISYVEKL-TPPEKAQPA 321
Query: 68 LPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDEL 127
P + G + + + + + EL
Sbjct: 322 RPPPPAQPGEIGEAIAK--------------------------------YNFNADTNVEL 349
Query: 128 ELKVGDIIDINEEVEEGWWSGTL--NNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLA 185
L+ GD + + + V++ W+ G + N+ G+FP ++V+ ++ G A+D
Sbjct: 350 SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG----AED------- 398
Query: 186 GPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPL 245
P PIP S ++ + +S+ KP++P+
Sbjct: 399 YPDPPIP---------------------------HSYSSDRIHSLSSN------KPQRPV 425
Query: 246 ILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGE 305
T + +G E + L+ Y NEDEL +E ++I ++ K +
Sbjct: 426 -------------FTHENIQG---GGEPFQALYNYTPRNEDELELRESDVIDVMEK--CD 467
Query: 306 AGWWRGELNGKE--GVFPDNFAVQI 328
GW+ G + G FP N+ ++
Sbjct: 468 DGWFVGTSRRTKFFGTFPGNYVKRL 492
Score = 50.8 bits (120), Expect = 4e-06
Identities = 26/88 (29%), Positives = 51/88 (57%), Gaps = 5/88 (5%)
Query: 269 KAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQI 328
K K + ++ ++ EL+FK+G+ ++++ K + W+ GE +G+ G+FP ++ ++
Sbjct: 255 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKL 312
Query: 329 NELDKDFPKPKKPPPPAKAPAPKPELIA 356
+K +P +PPPPA+ P E IA
Sbjct: 313 TPPEK--AQPARPPPPAQ-PGEIGEAIA 337
>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
Length = 1004
Score = 83.2 bits (204), Expect = 7e-16
Identities = 53/165 (32%), Positives = 96/165 (58%), Gaps = 12/165 (7%)
Query: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNG--RRGMFPDNFVKEIKRETE 62
I +Y+++A + EL++R G+ + +K++ ++ W EG++ G R+G+FP ++V+ +K+ T+
Sbjct: 848 IAKYNFNADTNVELSLRKGDRVILLKRV-DQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 906
Query: 63 FKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQ 122
+D P H + + +S+ P + H +NI+ + Q L+ Y P+
Sbjct: 907 GAED-YPDPPIPHSYSSDRIHSLSS-NKPQRPVFTH---ENIQGGGEPFQA--LYNYTPR 959
Query: 123 NEDELELKVGDIIDINEEVEEGWWSGTLNNK--LGLFPSNFVKEL 165
NEDELEL+ D+ID+ E+ ++GW+ GT G FP N+VK L
Sbjct: 960 NEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
Score = 55.8 bits (133), Expect = 1e-07
Identities = 65/325 (20%), Positives = 128/325 (39%), Gaps = 100/325 (30%)
Query: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDS 67
YD+ A EL+ + G+ + ++K+ ++ W EGE +GR G+FP ++V+++ E +
Sbjct: 776 YDFKAQTSKELSFKKGDTVYILRKI-DQNWYEGEHHGRVGIFPISYVEKL-TPPEKAQPA 833
Query: 68 LPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDEL 127
P + G + + + + + EL
Sbjct: 834 RPPPPAQPGEIGEAIAK--------------------------------YNFNADTNVEL 861
Query: 128 ELKVGDIIDINEEVEEGWWSGTL--NNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLA 185
L+ GD + + + V++ W+ G + N+ G+FP ++V+ ++ G A+D
Sbjct: 862 SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG----AED------- 910
Query: 186 GPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPL 245
P PIP S ++ + +S+ KP++P+
Sbjct: 911 YPDPPIP---------------------------HSYSSDRIHSLSSN------KPQRPV 937
Query: 246 ILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGE 305
T + +G E + L+ Y NEDEL +E ++I ++ K +
Sbjct: 938 -------------FTHENIQG---GGEPFQALYNYTPRNEDELELRESDVIDVMEK--CD 979
Query: 306 AGWWRGELNGKE--GVFPDNFAVQI 328
GW+ G + G FP N+ ++
Sbjct: 980 DGWFVGTSRRTKFFGTFPGNYVKRL 1004
Score = 50.8 bits (120), Expect = 4e-06
Identities = 26/88 (29%), Positives = 51/88 (57%), Gaps = 5/88 (5%)
Query: 269 KAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQI 328
K K + ++ ++ EL+FK+G+ ++++ K + W+ GE +G+ G+FP ++ ++
Sbjct: 767 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKL 824
Query: 329 NELDKDFPKPKKPPPPAKAPAPKPELIA 356
+K +P +PPPPA+ P E IA
Sbjct: 825 TPPEK--AQPARPPPPAQ-PGEIGEAIA 849
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 83.2 bits (204), Expect = 7e-16
Identities = 53/165 (32%), Positives = 96/165 (58%), Gaps = 12/165 (7%)
Query: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNG--RRGMFPDNFVKEIKRETE 62
I +Y+++A + EL++R G+ + +K++ ++ W EG++ G R+G+FP ++V+ +K+ T+
Sbjct: 668 IAKYNFNADTNVELSLRKGDRVILLKRV-DQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 726
Query: 63 FKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQ 122
+D P H + + +S+ P + H +NI+ + Q L+ Y P+
Sbjct: 727 GAED-YPDPPIPHSYSSDRIHSLSS-NKPQRPVFTH---ENIQGGGEPFQA--LYNYTPR 779
Query: 123 NEDELELKVGDIIDINEEVEEGWWSGTLNNK--LGLFPSNFVKEL 165
NEDELEL+ D+ID+ E+ ++GW+ GT G FP N+VK L
Sbjct: 780 NEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
Score = 55.8 bits (133), Expect = 1e-07
Identities = 65/325 (20%), Positives = 128/325 (39%), Gaps = 100/325 (30%)
Query: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDS 67
YD+ A EL+ + G+ + ++K+ ++ W EGE +GR G+FP ++V+++ E +
Sbjct: 596 YDFKAQTSKELSFKKGDTVYILRKI-DQNWYEGEHHGRVGIFPISYVEKL-TPPEKAQPA 653
Query: 68 LPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDEL 127
P + G + + + + + EL
Sbjct: 654 RPPPPAQPGEIGEAIAK--------------------------------YNFNADTNVEL 681
Query: 128 ELKVGDIIDINEEVEEGWWSGTL--NNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLA 185
L+ GD + + + V++ W+ G + N+ G+FP ++V+ ++ G A+D
Sbjct: 682 SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG----AED------- 730
Query: 186 GPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPL 245
P PIP S ++ + +S+ KP++P+
Sbjct: 731 YPDPPIP---------------------------HSYSSDRIHSLSSN------KPQRPV 757
Query: 246 ILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGE 305
T + +G E + L+ Y NEDEL +E ++I ++ K +
Sbjct: 758 -------------FTHENIQG---GGEPFQALYNYTPRNEDELELRESDVIDVMEK--CD 799
Query: 306 AGWWRGELNGKE--GVFPDNFAVQI 328
GW+ G + G FP N+ ++
Sbjct: 800 DGWFVGTSRRTKFFGTFPGNYVKRL 824
Score = 50.8 bits (120), Expect = 4e-06
Identities = 26/88 (29%), Positives = 51/88 (57%), Gaps = 5/88 (5%)
Query: 269 KAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQI 328
K K + ++ ++ EL+FK+G+ ++++ K + W+ GE +G+ G+FP ++ ++
Sbjct: 587 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKL 644
Query: 329 NELDKDFPKPKKPPPPAKAPAPKPELIA 356
+K +P +PPPPA+ P E IA
Sbjct: 645 TPPEK--AQPARPPPPAQ-PGEIGEAIA 669
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 83.2 bits (204), Expect = 7e-16
Identities = 53/165 (32%), Positives = 96/165 (58%), Gaps = 12/165 (7%)
Query: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNG--RRGMFPDNFVKEIKRETE 62
I +Y+++A + EL++R G+ + +K++ ++ W EG++ G R+G+FP ++V+ +K+ T+
Sbjct: 505 IAKYNFNADTNVELSLRKGDRVILLKRV-DQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 563
Query: 63 FKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQ 122
+D P H + + +S+ P + H +NI+ + Q L+ Y P+
Sbjct: 564 GAED-YPDPPIPHSYSSDRIHSLSS-NKPQRPVFTH---ENIQGGGEPFQA--LYNYTPR 616
Query: 123 NEDELELKVGDIIDINEEVEEGWWSGTLNNK--LGLFPSNFVKEL 165
NEDELEL+ D+ID+ E+ ++GW+ GT G FP N+VK L
Sbjct: 617 NEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
Score = 55.8 bits (133), Expect = 1e-07
Identities = 65/325 (20%), Positives = 128/325 (39%), Gaps = 100/325 (30%)
Query: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDS 67
YD+ A EL+ + G+ + ++K+ ++ W EGE +GR G+FP ++V+++ E +
Sbjct: 433 YDFKAQTSKELSFKKGDTVYILRKI-DQNWYEGEHHGRVGIFPISYVEKL-TPPEKAQPA 490
Query: 68 LPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDEL 127
P + G + + + + + EL
Sbjct: 491 RPPPPAQPGEIGEAIAK--------------------------------YNFNADTNVEL 518
Query: 128 ELKVGDIIDINEEVEEGWWSGTL--NNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLA 185
L+ GD + + + V++ W+ G + N+ G+FP ++V+ ++ G A+D
Sbjct: 519 SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG----AED------- 567
Query: 186 GPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPL 245
P PIP S ++ + +S+ KP++P+
Sbjct: 568 YPDPPIP---------------------------HSYSSDRIHSLSSN------KPQRPV 594
Query: 246 ILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGE 305
T + +G E + L+ Y NEDEL +E ++I ++ K +
Sbjct: 595 -------------FTHENIQG---GGEPFQALYNYTPRNEDELELRESDVIDVMEK--CD 636
Query: 306 AGWWRGELNGKE--GVFPDNFAVQI 328
GW+ G + G FP N+ ++
Sbjct: 637 DGWFVGTSRRTKFFGTFPGNYVKRL 661
Score = 50.8 bits (120), Expect = 4e-06
Identities = 26/88 (29%), Positives = 51/88 (57%), Gaps = 5/88 (5%)
Query: 269 KAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQI 328
K K + ++ ++ EL+FK+G+ ++++ K + W+ GE +G+ G+FP ++ ++
Sbjct: 424 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKL 481
Query: 329 NELDKDFPKPKKPPPPAKAPAPKPELIA 356
+K +P +PPPPA+ P E IA
Sbjct: 482 TPPEK--AQPARPPPPAQ-PGEIGEAIA 506
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 83.2 bits (204), Expect = 7e-16
Identities = 53/165 (32%), Positives = 96/165 (58%), Gaps = 12/165 (7%)
Query: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNG--RRGMFPDNFVKEIKRETE 62
I +Y+++A + EL++R G+ + +K++ ++ W EG++ G R+G+FP ++V+ +K+ T+
Sbjct: 575 IAKYNFNADTNVELSLRKGDRVILLKRV-DQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 633
Query: 63 FKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQ 122
+D P H + + +S+ P + H +NI+ + Q L+ Y P+
Sbjct: 634 GAED-YPDPPIPHSYSSDRIHSLSS-NKPQRPVFTH---ENIQGGGEPFQA--LYNYTPR 686
Query: 123 NEDELELKVGDIIDINEEVEEGWWSGTLNNK--LGLFPSNFVKEL 165
NEDELEL+ D+ID+ E+ ++GW+ GT G FP N+VK L
Sbjct: 687 NEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
Score = 55.8 bits (133), Expect = 1e-07
Identities = 65/325 (20%), Positives = 128/325 (39%), Gaps = 100/325 (30%)
Query: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDS 67
YD+ A EL+ + G+ + ++K+ ++ W EGE +GR G+FP ++V+++ E +
Sbjct: 503 YDFKAQTSKELSFKKGDTVYILRKI-DQNWYEGEHHGRVGIFPISYVEKL-TPPEKAQPA 560
Query: 68 LPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDEL 127
P + G + + + + + EL
Sbjct: 561 RPPPPAQPGEIGEAIAK--------------------------------YNFNADTNVEL 588
Query: 128 ELKVGDIIDINEEVEEGWWSGTL--NNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLA 185
L+ GD + + + V++ W+ G + N+ G+FP ++V+ ++ G A+D
Sbjct: 589 SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG----AED------- 637
Query: 186 GPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPL 245
P PIP S ++ + +S+ KP++P+
Sbjct: 638 YPDPPIP---------------------------HSYSSDRIHSLSSN------KPQRPV 664
Query: 246 ILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGE 305
T + +G E + L+ Y NEDEL +E ++I ++ K +
Sbjct: 665 -------------FTHENIQG---GGEPFQALYNYTPRNEDELELRESDVIDVMEK--CD 706
Query: 306 AGWWRGELNGKE--GVFPDNFAVQI 328
GW+ G + G FP N+ ++
Sbjct: 707 DGWFVGTSRRTKFFGTFPGNYVKRL 731
Score = 50.8 bits (120), Expect = 4e-06
Identities = 26/88 (29%), Positives = 51/88 (57%), Gaps = 5/88 (5%)
Query: 269 KAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQI 328
K K + ++ ++ EL+FK+G+ ++++ K + W+ GE +G+ G+FP ++ ++
Sbjct: 494 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKL 551
Query: 329 NELDKDFPKPKKPPPPAKAPAPKPELIA 356
+K +P +PPPPA+ P E IA
Sbjct: 552 TPPEK--AQPARPPPPAQ-PGEIGEAIA 576
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 83.2 bits (204), Expect = 7e-16
Identities = 53/165 (32%), Positives = 96/165 (58%), Gaps = 12/165 (7%)
Query: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNG--RRGMFPDNFVKEIKRETE 62
I +Y+++A + EL++R G+ + +K++ ++ W EG++ G R+G+FP ++V+ +K+ T+
Sbjct: 488 IAKYNFNADTNVELSLRKGDRVILLKRV-DQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 546
Query: 63 FKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQ 122
+D P H + + +S+ P + H +NI+ + Q L+ Y P+
Sbjct: 547 GAED-YPDPPIPHSYSSDRIHSLSS-NKPQRPVFTH---ENIQGGGEPFQA--LYNYTPR 599
Query: 123 NEDELELKVGDIIDINEEVEEGWWSGTLNNK--LGLFPSNFVKEL 165
NEDELEL+ D+ID+ E+ ++GW+ GT G FP N+VK L
Sbjct: 600 NEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
Score = 55.8 bits (133), Expect = 1e-07
Identities = 65/325 (20%), Positives = 128/325 (39%), Gaps = 100/325 (30%)
Query: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDS 67
YD+ A EL+ + G+ + ++K+ ++ W EGE +GR G+FP ++V+++ E +
Sbjct: 416 YDFKAQTSKELSFKKGDTVYILRKI-DQNWYEGEHHGRVGIFPISYVEKL-TPPEKAQPA 473
Query: 68 LPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDEL 127
P + G + + + + + EL
Sbjct: 474 RPPPPAQPGEIGEAIAK--------------------------------YNFNADTNVEL 501
Query: 128 ELKVGDIIDINEEVEEGWWSGTL--NNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLA 185
L+ GD + + + V++ W+ G + N+ G+FP ++V+ ++ G A+D
Sbjct: 502 SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG----AED------- 550
Query: 186 GPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPL 245
P PIP S ++ + +S+ KP++P+
Sbjct: 551 YPDPPIP---------------------------HSYSSDRIHSLSSN------KPQRPV 577
Query: 246 ILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGE 305
T + +G E + L+ Y NEDEL +E ++I ++ K +
Sbjct: 578 -------------FTHENIQG---GGEPFQALYNYTPRNEDELELRESDVIDVMEK--CD 619
Query: 306 AGWWRGELNGKE--GVFPDNFAVQI 328
GW+ G + G FP N+ ++
Sbjct: 620 DGWFVGTSRRTKFFGTFPGNYVKRL 644
Score = 50.8 bits (120), Expect = 4e-06
Identities = 26/88 (29%), Positives = 51/88 (57%), Gaps = 5/88 (5%)
Query: 269 KAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQI 328
K K + ++ ++ EL+FK+G+ ++++ K + W+ GE +G+ G+FP ++ ++
Sbjct: 407 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKL 464
Query: 329 NELDKDFPKPKKPPPPAKAPAPKPELIA 356
+K +P +PPPPA+ P E IA
Sbjct: 465 TPPEK--AQPARPPPPAQ-PGEIGEAIA 489
>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
Length = 1100
Score = 83.2 bits (204), Expect = 7e-16
Identities = 53/165 (32%), Positives = 96/165 (58%), Gaps = 12/165 (7%)
Query: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNG--RRGMFPDNFVKEIKRETE 62
I +Y+++A + EL++R G+ + +K++ ++ W EG++ G R+G+FP ++V+ +K+ T+
Sbjct: 944 IAKYNFNADTNVELSLRKGDRVILLKRV-DQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 1002
Query: 63 FKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQ 122
+D P H + + +S+ P + H +NI+ + Q L+ Y P+
Sbjct: 1003 GAED-YPDPPIPHSYSSDRIHSLSS-NKPQRPVFTH---ENIQGGGEPFQA--LYNYTPR 1055
Query: 123 NEDELELKVGDIIDINEEVEEGWWSGTLNNK--LGLFPSNFVKEL 165
NEDELEL+ D+ID+ E+ ++GW+ GT G FP N+VK L
Sbjct: 1056 NEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
Score = 55.8 bits (133), Expect = 1e-07
Identities = 65/325 (20%), Positives = 128/325 (39%), Gaps = 100/325 (30%)
Query: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDS 67
YD+ A EL+ + G+ + ++K+ ++ W EGE +GR G+FP ++V+++ E +
Sbjct: 872 YDFKAQTSKELSFKKGDTVYILRKI-DQNWYEGEHHGRVGIFPISYVEKL-TPPEKAQPA 929
Query: 68 LPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDEL 127
P + G + + + + + EL
Sbjct: 930 RPPPPAQPGEIGEAIAK--------------------------------YNFNADTNVEL 957
Query: 128 ELKVGDIIDINEEVEEGWWSGTL--NNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLA 185
L+ GD + + + V++ W+ G + N+ G+FP ++V+ ++ G A+D
Sbjct: 958 SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG----AED------- 1006
Query: 186 GPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPL 245
P PIP S ++ + +S+ KP++P+
Sbjct: 1007 YPDPPIP---------------------------HSYSSDRIHSLSSN------KPQRPV 1033
Query: 246 ILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGE 305
T + +G E + L+ Y NEDEL +E ++I ++ K +
Sbjct: 1034 -------------FTHENIQG---GGEPFQALYNYTPRNEDELELRESDVIDVMEK--CD 1075
Query: 306 AGWWRGELNGKE--GVFPDNFAVQI 328
GW+ G + G FP N+ ++
Sbjct: 1076 DGWFVGTSRRTKFFGTFPGNYVKRL 1100
Score = 50.8 bits (120), Expect = 4e-06
Identities = 26/88 (29%), Positives = 51/88 (57%), Gaps = 5/88 (5%)
Query: 269 KAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQI 328
K K + ++ ++ EL+FK+G+ ++++ K + W+ GE +G+ G+FP ++ ++
Sbjct: 863 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKL 920
Query: 329 NELDKDFPKPKKPPPPAKAPAPKPELIA 356
+K +P +PPPPA+ P E IA
Sbjct: 921 TPPEK--AQPARPPPPAQ-PGEIGEAIA 945
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 83.2 bits (204), Expect = 7e-16
Identities = 53/165 (32%), Positives = 96/165 (58%), Gaps = 12/165 (7%)
Query: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNG--RRGMFPDNFVKEIKRETE 62
I +Y+++A + EL++R G+ + +K++ ++ W EG++ G R+G+FP ++V+ +K+ T+
Sbjct: 510 IAKYNFNADTNVELSLRKGDRVILLKRV-DQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 568
Query: 63 FKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQ 122
+D P H + + +S+ P + H +NI+ + Q L+ Y P+
Sbjct: 569 GAED-YPDPPIPHSYSSDRIHSLSS-NKPQRPVFTH---ENIQGGGEPFQA--LYNYTPR 621
Query: 123 NEDELELKVGDIIDINEEVEEGWWSGTLNNK--LGLFPSNFVKEL 165
NEDELEL+ D+ID+ E+ ++GW+ GT G FP N+VK L
Sbjct: 622 NEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 666
Score = 55.8 bits (133), Expect = 1e-07
Identities = 65/325 (20%), Positives = 128/325 (39%), Gaps = 100/325 (30%)
Query: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDS 67
YD+ A EL+ + G+ + ++K+ ++ W EGE +GR G+FP ++V+++ E +
Sbjct: 438 YDFKAQTSKELSFKKGDTVYILRKI-DQNWYEGEHHGRVGIFPISYVEKL-TPPEKAQPA 495
Query: 68 LPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDEL 127
P + G + + + + + EL
Sbjct: 496 RPPPPAQPGEIGEAIAK--------------------------------YNFNADTNVEL 523
Query: 128 ELKVGDIIDINEEVEEGWWSGTL--NNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLA 185
L+ GD + + + V++ W+ G + N+ G+FP ++V+ ++ G A+D
Sbjct: 524 SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG----AED------- 572
Query: 186 GPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPL 245
P PIP S ++ + +S+ KP++P+
Sbjct: 573 YPDPPIP---------------------------HSYSSDRIHSLSSN------KPQRPV 599
Query: 246 ILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGE 305
T + +G E + L+ Y NEDEL +E ++I ++ K +
Sbjct: 600 -------------FTHENIQG---GGEPFQALYNYTPRNEDELELRESDVIDVMEK--CD 641
Query: 306 AGWWRGELNGKE--GVFPDNFAVQI 328
GW+ G + G FP N+ ++
Sbjct: 642 DGWFVGTSRRTKFFGTFPGNYVKRL 666
Score = 51.2 bits (121), Expect = 3e-06
Identities = 65/283 (22%), Positives = 116/283 (40%), Gaps = 37/283 (13%)
Query: 99 PQTKNIKKKTKKRQCKVLFEYIP------QNEDELELKVGDIIDINEEVEEGWWSGTLNN 152
P + + + + + + +FEY P Q+E + D ID+ E W+
Sbjct: 241 PPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPTDRINPDDIDLENEP---WYKFFSEL 297
Query: 153 KLGLFPSNFVKELEVTDD---GETHEAQDDSETVLAGPTSPIPSLGNVSETASGSVTQPK 209
+ G P K L+ D G +EA ++ P+ S S+ ++P
Sbjct: 298 EFGRPPPK--KPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPA 355
Query: 210 KIRGIGFGD----------IFKEGSVKLRTRT-----SSSETEEKKPEKPLILQS-LGPK 253
G GD + GS T++ SS + K E P S L
Sbjct: 356 VGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDM 415
Query: 254 TQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGEL 313
+S + T K K + ++ ++ EL+FK+G+ ++++ K + W+ GE
Sbjct: 416 GRSAPRERRGTPEKEKLP--AKAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEH 471
Query: 314 NGKEGVFPDNFAVQINELDKDFPKPKKPPPPAKAPAPKPELIA 356
+G+ G+FP ++ ++ +K +P +PPPPA+ P E IA
Sbjct: 472 HGRVGIFPISYVEKLTPPEK--AQPARPPPPAQ-PGEIGEAIA 511
>gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
sapiens]
Length = 905
Score = 82.0 bits (201), Expect = 2e-15
Identities = 57/184 (30%), Positives = 95/184 (51%), Gaps = 27/184 (14%)
Query: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNG--RRGMFPDNFVKEIKRE-- 60
I +++++ E++ R GE I ++++ +E W EG + G R+G+FP +V IKR
Sbjct: 724 IAKFNFNGDTQVEMSFRKGERITLLRQV-DENWYEGRIPGTSRQGIFPITYVDVIKRPLV 782
Query: 61 ---TEFKDDSLPIKRERHGNVASLVQRISTYGLPAGG---------IQPHPQTKNIKKKT 108
++ D LP + + Q +S + L AG +QP Q + +
Sbjct: 783 KNPVDYMD--LPFSSSPSRSATASPQ-LSHHSLRAGPDLTESEKSYVQPQAQQRRVTPDR 839
Query: 109 KKRQ-----CKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGT--LNNKLGLFPSNF 161
+ + L+ YIPQN+DELEL+ GDI+D+ E+ ++GW+ GT + G FP N+
Sbjct: 840 SQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNY 899
Query: 162 VKEL 165
VK L
Sbjct: 900 VKPL 903
Score = 53.9 bits (128), Expect = 4e-07
Identities = 71/312 (22%), Positives = 129/312 (41%), Gaps = 50/312 (16%)
Query: 55 KEIKRETEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCK 114
+ +KRE E D I RH V + T G + T K ++ R +
Sbjct: 596 RRLKREQEEAD----IAARRHTGVIPTHHQFIT-NERFGDLLNIDDTAKRKSGSEMRPAR 650
Query: 115 VLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKEL--------- 165
F++ Q EL L+ GDI+ I +++++ W+ G + ++G+FP +++ L
Sbjct: 651 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPK 710
Query: 166 -----EVTDDGET---HEAQDDSETVLA-GPTSPIPSLGNVSET-ASGSV--TQPKKIRG 213
+V + GE D++ ++ I L V E G + T + I
Sbjct: 711 KLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFP 770
Query: 214 IGFGDIFKEGSVK-------LRTRTSSSETEEKKPE--------KPLILQS----LGPKT 254
I + D+ K VK L +S S + P+ P + +S + P+
Sbjct: 771 ITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQA 830
Query: 255 QSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELN 314
Q +T ++ Y + L++Y N+DEL ++G+I+ ++ K + GW+ G
Sbjct: 831 QQRRVTPDRSQTSQDLFSY-QALYSYIPQNDDELELRDGDIVDVMEK--CDDGWFVGTSR 887
Query: 315 GKE--GVFPDNF 324
+ G FP N+
Sbjct: 888 RTKQFGTFPGNY 899
Score = 36.6 bits (83), Expect = 0.073
Identities = 20/59 (33%), Positives = 32/59 (54%), Gaps = 3/59 (5%)
Query: 1 MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRR--GMFPDNFVKEI 57
+ Y Y Y +DDEL +R G+I+ ++K ++GW G + G FP N+VK +
Sbjct: 846 LFSYQALYSYIPQNDDELELRDGDIVDVMEKC-DDGWFVGTSRRTKQFGTFPGNYVKPL 903
Score = 35.8 bits (81), Expect = 0.12
Identities = 17/67 (25%), Positives = 34/67 (50%), Gaps = 2/67 (2%)
Query: 275 RTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINELDKD 334
R F ++ EL ++G+I+++ + + W+ GE +G+ G+FP + + +K
Sbjct: 650 RAKFDFKAQTLKELPLQKGDIVYIYKQI--DQNWYEGEHHGRVGIFPRTYIELLPPAEKA 707
Query: 335 FPKPKKP 341
PK P
Sbjct: 708 QPKKLTP 714
>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
sapiens]
Length = 740
Score = 78.6 bits (192), Expect = 2e-14
Identities = 56/175 (32%), Positives = 91/175 (52%), Gaps = 29/175 (16%)
Query: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNG--RRGMFPDNFVKEIKRE-- 60
I +++++ E++ R GE I ++++ +E W EG + G R+G+FP +V IKR
Sbjct: 579 IAKFNFNGDTQVEMSFRKGERITLLRQV-DENWYEGRIPGTSRQGIFPITYVDVIKRPLV 637
Query: 61 ---TEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQ----- 112
++ D LP +S R +T A QP Q + + +
Sbjct: 638 KNPVDYMD--LPF--------SSSPSRSAT----ASPQQPQAQQRRVTPDRSQTSQDLFS 683
Query: 113 CKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGT--LNNKLGLFPSNFVKEL 165
+ L+ YIPQN+DELEL+ GDI+D+ E+ ++GW+ GT + G FP N+VK L
Sbjct: 684 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
Score = 57.4 bits (137), Expect = 4e-08
Identities = 69/300 (23%), Positives = 125/300 (41%), Gaps = 46/300 (15%)
Query: 55 KEIKRETEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCK 114
+ +KRE E D I RH V + T G + T K ++ R +
Sbjct: 451 RRLKREQEEAD----IAARRHTGVIPTHHQFIT-NERFGDLLNIDDTAKRKSGSEMRPAR 505
Query: 115 VLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKEL--------- 165
F++ Q EL L+ GDI+ I +++++ W+ G + ++G+FP +++ L
Sbjct: 506 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPK 565
Query: 166 -----EVTDDGET---HEAQDDSETVLA-GPTSPIPSLGNVSET-ASGSV--TQPKKIRG 213
+V + GE D++ ++ I L V E G + T + I
Sbjct: 566 KLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFP 625
Query: 214 IGFGDIFKEGSVK-------LRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEG 266
I + D+ K VK L +S S + P++ P+ Q +T ++
Sbjct: 626 ITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQ--------PQAQQRRVTPDRSQT 677
Query: 267 KIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKE--GVFPDNF 324
Y + L++Y N+DEL ++G+I+ ++ K + GW+ G + G FP N+
Sbjct: 678 SQDLFSY-QALYSYIPQNDDELELRDGDIVDVMEK--CDDGWFVGTSRRTKQFGTFPGNY 734
Score = 36.6 bits (83), Expect = 0.073
Identities = 20/59 (33%), Positives = 32/59 (54%), Gaps = 3/59 (5%)
Query: 1 MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRR--GMFPDNFVKEI 57
+ Y Y Y +DDEL +R G+I+ ++K ++GW G + G FP N+VK +
Sbjct: 681 LFSYQALYSYIPQNDDELELRDGDIVDVMEKC-DDGWFVGTSRRTKQFGTFPGNYVKPL 738
Score = 35.8 bits (81), Expect = 0.12
Identities = 17/67 (25%), Positives = 34/67 (50%), Gaps = 2/67 (2%)
Query: 275 RTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINELDKD 334
R F ++ EL ++G+I+++ + + W+ GE +G+ G+FP + + +K
Sbjct: 505 RAKFDFKAQTLKELPLQKGDIVYIYKQI--DQNWYEGEHHGRVGIFPRTYIELLPPAEKA 562
Query: 335 FPKPKKP 341
PK P
Sbjct: 563 QPKKLTP 569
>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
sapiens]
Length = 781
Score = 78.6 bits (192), Expect = 2e-14
Identities = 56/175 (32%), Positives = 91/175 (52%), Gaps = 29/175 (16%)
Query: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNG--RRGMFPDNFVKEIKRE-- 60
I +++++ E++ R GE I ++++ +E W EG + G R+G+FP +V IKR
Sbjct: 620 IAKFNFNGDTQVEMSFRKGERITLLRQV-DENWYEGRIPGTSRQGIFPITYVDVIKRPLV 678
Query: 61 ---TEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQ----- 112
++ D LP +S R +T A QP Q + + +
Sbjct: 679 KNPVDYMD--LPF--------SSSPSRSAT----ASPQQPQAQQRRVTPDRSQTSQDLFS 724
Query: 113 CKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGT--LNNKLGLFPSNFVKEL 165
+ L+ YIPQN+DELEL+ GDI+D+ E+ ++GW+ GT + G FP N+VK L
Sbjct: 725 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
Score = 57.4 bits (137), Expect = 4e-08
Identities = 69/300 (23%), Positives = 125/300 (41%), Gaps = 46/300 (15%)
Query: 55 KEIKRETEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCK 114
+ +KRE E D I RH V + T G + T K ++ R +
Sbjct: 492 RRLKREQEEAD----IAARRHTGVIPTHHQFIT-NERFGDLLNIDDTAKRKSGSEMRPAR 546
Query: 115 VLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKEL--------- 165
F++ Q EL L+ GDI+ I +++++ W+ G + ++G+FP +++ L
Sbjct: 547 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPK 606
Query: 166 -----EVTDDGET---HEAQDDSETVLA-GPTSPIPSLGNVSET-ASGSV--TQPKKIRG 213
+V + GE D++ ++ I L V E G + T + I
Sbjct: 607 KLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFP 666
Query: 214 IGFGDIFKEGSVK-------LRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEG 266
I + D+ K VK L +S S + P++ P+ Q +T ++
Sbjct: 667 ITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQ--------PQAQQRRVTPDRSQT 718
Query: 267 KIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKE--GVFPDNF 324
Y + L++Y N+DEL ++G+I+ ++ K + GW+ G + G FP N+
Sbjct: 719 SQDLFSY-QALYSYIPQNDDELELRDGDIVDVMEK--CDDGWFVGTSRRTKQFGTFPGNY 775
Score = 36.6 bits (83), Expect = 0.073
Identities = 20/59 (33%), Positives = 32/59 (54%), Gaps = 3/59 (5%)
Query: 1 MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRR--GMFPDNFVKEI 57
+ Y Y Y +DDEL +R G+I+ ++K ++GW G + G FP N+VK +
Sbjct: 722 LFSYQALYSYIPQNDDELELRDGDIVDVMEKC-DDGWFVGTSRRTKQFGTFPGNYVKPL 779
Score = 35.8 bits (81), Expect = 0.12
Identities = 17/67 (25%), Positives = 34/67 (50%), Gaps = 2/67 (2%)
Query: 275 RTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINELDKD 334
R F ++ EL ++G+I+++ + + W+ GE +G+ G+FP + + +K
Sbjct: 546 RAKFDFKAQTLKELPLQKGDIVYIYKQI--DQNWYEGEHHGRVGIFPRTYIELLPPAEKA 603
Query: 335 FPKPKKP 341
PK P
Sbjct: 604 QPKKLTP 610
>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
sapiens]
Length = 816
Score = 78.6 bits (192), Expect = 2e-14
Identities = 56/175 (32%), Positives = 91/175 (52%), Gaps = 29/175 (16%)
Query: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNG--RRGMFPDNFVKEIKRE-- 60
I +++++ E++ R GE I ++++ +E W EG + G R+G+FP +V IKR
Sbjct: 655 IAKFNFNGDTQVEMSFRKGERITLLRQV-DENWYEGRIPGTSRQGIFPITYVDVIKRPLV 713
Query: 61 ---TEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQ----- 112
++ D LP +S R +T A QP Q + + +
Sbjct: 714 KNPVDYMD--LPF--------SSSPSRSAT----ASPQQPQAQQRRVTPDRSQTSQDLFS 759
Query: 113 CKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGT--LNNKLGLFPSNFVKEL 165
+ L+ YIPQN+DELEL+ GDI+D+ E+ ++GW+ GT + G FP N+VK L
Sbjct: 760 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814
Score = 53.5 bits (127), Expect = 6e-07
Identities = 56/244 (22%), Positives = 106/244 (43%), Gaps = 41/244 (16%)
Query: 111 RQCKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKEL----- 165
R + F++ Q EL L+ GDI+ I +++++ W+ G + ++G+FP +++ L
Sbjct: 578 RPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEK 637
Query: 166 ---------EVTDDGET---HEAQDDSETVLA-GPTSPIPSLGNVSET-ASGSV--TQPK 209
+V + GE D++ ++ I L V E G + T +
Sbjct: 638 AQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQ 697
Query: 210 KIRGIGFGDIFKEGSVK-------LRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKT 262
I I + D+ K VK L +S S + P++ P+ Q +T
Sbjct: 698 GIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQ--------PQAQQRRVTPD 749
Query: 263 DTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKE--GVF 320
++ Y + L++Y N+DEL ++G+I+ ++ K + GW+ G + G F
Sbjct: 750 RSQTSQDLFSY-QALYSYIPQNDDELELRDGDIVDVMEK--CDDGWFVGTSRRTKQFGTF 806
Query: 321 PDNF 324
P N+
Sbjct: 807 PGNY 810
Score = 41.6 bits (96), Expect = 0.002
Identities = 29/125 (23%), Positives = 56/125 (44%), Gaps = 6/125 (4%)
Query: 217 GDIFKEGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRT 276
GDI +G L+ +SS+ T++ + + I T+ + D K R
Sbjct: 527 GDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDD----KEMRPARA 582
Query: 277 LFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINELDKDFP 336
F ++ EL ++G+I+++ + + W+ GE +G+ G+FP + + +K P
Sbjct: 583 KFDFKAQTLKELPLQKGDIVYIYKQI--DQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 640
Query: 337 KPKKP 341
K P
Sbjct: 641 KKLTP 645
Score = 36.6 bits (83), Expect = 0.073
Identities = 20/59 (33%), Positives = 32/59 (54%), Gaps = 3/59 (5%)
Query: 1 MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRR--GMFPDNFVKEI 57
+ Y Y Y +DDEL +R G+I+ ++K ++GW G + G FP N+VK +
Sbjct: 757 LFSYQALYSYIPQNDDELELRDGDIVDVMEKC-DDGWFVGTSRRTKQFGTFPGNYVKPL 814
>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
sapiens]
Length = 684
Score = 78.6 bits (192), Expect = 2e-14
Identities = 56/175 (32%), Positives = 91/175 (52%), Gaps = 29/175 (16%)
Query: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNG--RRGMFPDNFVKEIKRE-- 60
I +++++ E++ R GE I ++++ +E W EG + G R+G+FP +V IKR
Sbjct: 523 IAKFNFNGDTQVEMSFRKGERITLLRQV-DENWYEGRIPGTSRQGIFPITYVDVIKRPLV 581
Query: 61 ---TEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQ----- 112
++ D LP +S R +T A QP Q + + +
Sbjct: 582 KNPVDYMD--LPF--------SSSPSRSAT----ASPQQPQAQQRRVTPDRSQTSQDLFS 627
Query: 113 CKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGT--LNNKLGLFPSNFVKEL 165
+ L+ YIPQN+DELEL+ GDI+D+ E+ ++GW+ GT + G FP N+VK L
Sbjct: 628 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682
Score = 53.5 bits (127), Expect = 6e-07
Identities = 56/244 (22%), Positives = 106/244 (43%), Gaps = 41/244 (16%)
Query: 111 RQCKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKEL----- 165
R + F++ Q EL L+ GDI+ I +++++ W+ G + ++G+FP +++ L
Sbjct: 446 RPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEK 505
Query: 166 ---------EVTDDGET---HEAQDDSETVLA-GPTSPIPSLGNVSET-ASGSV--TQPK 209
+V + GE D++ ++ I L V E G + T +
Sbjct: 506 AQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQ 565
Query: 210 KIRGIGFGDIFKEGSVK-------LRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKT 262
I I + D+ K VK L +S S + P++ P+ Q +T
Sbjct: 566 GIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQ--------PQAQQRRVTPD 617
Query: 263 DTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKE--GVF 320
++ Y + L++Y N+DEL ++G+I+ ++ K + GW+ G + G F
Sbjct: 618 RSQTSQDLFSY-QALYSYIPQNDDELELRDGDIVDVMEK--CDDGWFVGTSRRTKQFGTF 674
Query: 321 PDNF 324
P N+
Sbjct: 675 PGNY 678
Score = 41.6 bits (96), Expect = 0.002
Identities = 29/125 (23%), Positives = 56/125 (44%), Gaps = 6/125 (4%)
Query: 217 GDIFKEGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRT 276
GDI +G L+ +SS+ T++ + + I T+ + D K R
Sbjct: 395 GDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDD----KEMRPARA 450
Query: 277 LFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINELDKDFP 336
F ++ EL ++G+I+++ + + W+ GE +G+ G+FP + + +K P
Sbjct: 451 KFDFKAQTLKELPLQKGDIVYIYKQI--DQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 508
Query: 337 KPKKP 341
K P
Sbjct: 509 KKLTP 513
Score = 36.6 bits (83), Expect = 0.073
Identities = 20/59 (33%), Positives = 32/59 (54%), Gaps = 3/59 (5%)
Query: 1 MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRR--GMFPDNFVKEI 57
+ Y Y Y +DDEL +R G+I+ ++K ++GW G + G FP N+VK +
Sbjct: 625 LFSYQALYSYIPQNDDELELRDGDIVDVMEKC-DDGWFVGTSRRTKQFGTFPGNYVKPL 682
>gi|55956916 myosin IE [Homo sapiens]
Length = 1108
Score = 72.0 bits (175), Expect = 2e-12
Identities = 38/87 (43%), Positives = 51/87 (58%), Gaps = 3/87 (3%)
Query: 79 ASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDELELKVGDIIDIN 138
A+ V+R +T P G +P PQ K K + QCK L+ Y Q+ DEL DIIDI
Sbjct: 1025 AAGVRRQTTSRPPPAGGRPKPQPK---PKPQVPQCKALYAYDAQDTDELSFNANDIIDII 1081
Query: 139 EEVEEGWWSGTLNNKLGLFPSNFVKEL 165
+E GWW+G L K GLFP+N+V ++
Sbjct: 1082 KEDPSGWWTGRLRGKQGLFPNNYVTKI 1108
Score = 59.3 bits (142), Expect = 1e-08
Identities = 39/137 (28%), Positives = 65/137 (47%), Gaps = 23/137 (16%)
Query: 192 PSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPLILQSLG 251
P L T+S V+Q + + F + +G+ +R +T+S KP
Sbjct: 995 PPLPRQQSTSSDRVSQTPE--SLDFLKVPDQGAAGVRRQTTSRPPPAGGRPKP----QPK 1048
Query: 252 PKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRG 311
PK Q + C+ L+AY+ + DEL+F +II +I ++ +GWW G
Sbjct: 1049 PKPQVPQ---------------CKALYAYDAQDTDELSFNANDIIDIIKEDP--SGWWTG 1091
Query: 312 ELNGKEGVFPDNFAVQI 328
L GK+G+FP+N+ +I
Sbjct: 1092 RLRGKQGLFPNNYVTKI 1108
Score = 45.8 bits (107), Expect = 1e-04
Identities = 21/50 (42%), Positives = 31/50 (62%), Gaps = 1/50 (2%)
Query: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEI 57
Y YDA DEL+ +II +K+ GW G L G++G+FP+N+V +I
Sbjct: 1060 YAYDAQDTDELSFNANDIIDIIKE-DPSGWWTGRLRGKQGLFPNNYVTKI 1108
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 70.1 bits (170), Expect = 6e-12
Identities = 49/149 (32%), Positives = 72/149 (48%), Gaps = 11/149 (7%)
Query: 15 DDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDSLPIKRER 74
D+EL R G++I + + E GW EGEL GRRG+FP+ FV E+ D+S+
Sbjct: 161 DEELDFREGDVI-TIIGVPEPGWFEGELEGRRGIFPEGFV-ELLGPLRTVDESVS----- 213
Query: 75 HGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDELELKVGDI 134
GN + P G + P + T L+ + +EL+ +VGD
Sbjct: 214 SGNQDDCIVN-GEVDTPVGEEEIGPDEDEEEPGTYG---VALYRFQALEPNELDFEVGDK 269
Query: 135 IDINEEVEEGWWSGTLNNKLGLFPSNFVK 163
I I +E+GW G+L + G+FP FVK
Sbjct: 270 IRILATLEDGWLEGSLKGRTGIFPYRFVK 298
Score = 60.8 bits (146), Expect = 4e-09
Identities = 85/357 (23%), Positives = 134/357 (37%), Gaps = 111/357 (31%)
Query: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFV--------KEIKR 59
+D+ +EL + VG+II V + +E WL G+ G FP +FV KE +R
Sbjct: 11 FDFCPSVSEELPLFVGDIIE-VLAVVDEFWLLGKKEDVTGQFPSSFVEIVTIPSLKEGER 69
Query: 60 E-------TEFKDDSLPIKRERHGNVASL--------VQRISTYGLPAGGIQPHPQTKNI 104
T + D+LP+ R G++ L +Q S +G A G P + +
Sbjct: 70 LFVCICEFTSQELDNLPLHR---GDLVILDGIPTAGWLQGRSCWG--ARGFFPSSCVREL 124
Query: 105 KKKTKKRQ-----------------CKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWS 147
++ RQ + L Q ++EL+ + GD+I I E GW+
Sbjct: 125 CLSSQSRQWHSQSALFQIPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFE 184
Query: 148 GTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGPTSPIPSLGNVSETASGSVTQ 207
G L + G+FP FV+ L GP L V E+ S
Sbjct: 185 GELEGRRGIFPEGFVE--------------------LLGP------LRTVDESVSSGNQD 218
Query: 208 PKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEGK 267
D G V + P+ + +GP E +
Sbjct: 219 ----------DCIVNGEV----------------DTPVGEEEIGPD-----------EDE 241
Query: 268 IKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNF 324
+ Y L+ ++ +EL F+ G+ I +++ T E GW G L G+ G+FP F
Sbjct: 242 EEPGTYGVALYRFQALEPNELDFEVGDKIRILA--TLEDGWLEGSLKGRTGIFPYRF 296
Score = 46.6 bits (109), Expect = 7e-05
Identities = 21/57 (36%), Positives = 32/57 (56%), Gaps = 2/57 (3%)
Query: 275 RTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINEL 331
R L ++EL F+EG++I +I E GW+ GEL G+ G+FP+ F + L
Sbjct: 151 RALMGLSAQLDEELDFREGDVITIIG--VPEPGWFEGELEGRRGIFPEGFVELLGPL 205
Score = 43.5 bits (101), Expect = 6e-04
Identities = 20/50 (40%), Positives = 31/50 (62%)
Query: 114 KVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVK 163
+ +F++ P +EL L VGDII++ V+E W G + G FPS+FV+
Sbjct: 8 RAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVE 57
Score = 38.9 bits (89), Expect = 0.015
Identities = 19/75 (25%), Positives = 38/75 (50%), Gaps = 6/75 (8%)
Query: 252 PKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKE--TGEAGWW 309
P+ +S E ++ EG + ++ ++ N +EL+ + + ++ + TG WW
Sbjct: 1500 PEDRSTEPDGSEAEGN----QVYFAVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWW 1555
Query: 310 RGELNGKEGVFPDNF 324
E+NGK+G P N+
Sbjct: 1556 LAEVNGKKGYVPSNY 1570
Score = 33.5 bits (75), Expect = 0.62
Identities = 17/59 (28%), Positives = 31/59 (52%), Gaps = 8/59 (13%)
Query: 116 LFEYIPQNEDEL------ELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVT 168
++ + +N +EL +LK+ + D+ E WW +N K G PSN++++ E T
Sbjct: 1521 VYTFKARNPNELSVSANQKLKILEFKDVTGNTE--WWLAEVNGKKGYVPSNYIRKTEYT 1577
Score = 30.8 bits (68), Expect = 4.0
Identities = 16/63 (25%), Positives = 33/63 (52%), Gaps = 7/63 (11%)
Query: 4 YIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEG---WLEGELNGRRGMFPDNFVKEIKRE 60
Y Y + A + +EL++ + ++ ++ G W E+NG++G P N++ R+
Sbjct: 1518 YFAVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWLAEVNGKKGYVPSNYI----RK 1573
Query: 61 TEF 63
TE+
Sbjct: 1574 TEY 1576
>gi|182765466 FCH and double SH3 domains 2 [Homo sapiens]
Length = 740
Score = 67.0 bits (162), Expect = 5e-11
Identities = 57/204 (27%), Positives = 83/204 (40%), Gaps = 46/204 (22%)
Query: 246 ILQSLGPKTQSVEITKTDTEGKIKAKE--------YCRTLFAYEGTNEDELTFKEGEIIH 297
+LQSL + TE ++ + + + L+ YEG +DEL+F EG II
Sbjct: 536 MLQSLAALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTDDELSFPEGAIIR 595
Query: 298 LISKET-GEAGWWRGELNGKEGVFPDNFAVQINELDKD----------FPKPKK----PP 342
+++KE + G+W GE NG+ GVFP +++ + P PK PP
Sbjct: 596 ILNKENQDDDGFWEGEFNGRIGVFPSVLVEELSASENGDTPWMREIQISPSPKPHASLPP 655
Query: 343 -----PPAKAPAPKPELIAAEKKYFSLKPEEKDEKSTLEQKPSKPAAPQVPPKKPTPPTK 397
P +P P P+ YF P +EKS + P A + TP T
Sbjct: 656 LPLYDQPPSSPYPSPD--KRSSLYFPRSP-SANEKSLHAESPGFSQA-----SRHTPETS 707
Query: 398 ASNLLRSSGTVYPKRPEKPVPPPP 421
L RP + PPPP
Sbjct: 708 YGKL----------RPVRAAPPPP 721
Score = 65.1 bits (157), Expect = 2e-10
Identities = 50/215 (23%), Positives = 89/215 (41%), Gaps = 16/215 (7%)
Query: 6 VEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELN-GRRGMFPDNFVKEIKRETEFK 64
V Y Y A DELTI E++ ++ E W++ G+ G P+ +++
Sbjct: 476 VVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQ--------- 526
Query: 65 DDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNE 124
P + SL S + + + ++ K L++Y Q +
Sbjct: 527 ---FPTSNSLLSMLQSLAALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTD 583
Query: 125 DELELKVGDIIDI---NEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSE 181
DEL G II I + ++G+W G N ++G+FPS V+EL +++G+T ++
Sbjct: 584 DELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEELSASENGDTPWMREIQI 643
Query: 182 TVLAGPTSPIPSLGNVSETASGSVTQPKKIRGIGF 216
+ P + +P L + S P K + F
Sbjct: 644 SPSPKPHASLPPLPLYDQPPSSPYPSPDKRSSLYF 678
Score = 32.3 bits (72), Expect = 1.4
Identities = 16/53 (30%), Positives = 30/53 (56%), Gaps = 4/53 (7%)
Query: 274 CRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELN--GKEGVFPDNF 324
C+ +++Y+ + DELT +E E++ +I E G+ W N G+ G P+ +
Sbjct: 474 CKVVYSYKASQPDELTIEEHEVLEVI--EDGDMEDWVKARNKVGQVGYVPEKY 524
>gi|89886447 nitric oxide synthase trafficker isoform 2 [Homo
sapiens]
Length = 506
Score = 65.1 bits (157), Expect = 2e-10
Identities = 28/55 (50%), Positives = 40/55 (72%)
Query: 111 RQCKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKEL 165
R CK L+ + + +DEL L+ GDI+ I+E+ EEGWW G+LN K G FP+ +V+EL
Sbjct: 441 RLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEEL 495
Score = 51.2 bits (121), Expect = 3e-06
Identities = 21/55 (38%), Positives = 35/55 (63%), Gaps = 2/55 (3%)
Query: 274 CRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQI 328
C+ L++++ +DEL ++G+I+ I E E GWW G LNGK+G FP + ++
Sbjct: 443 CKALYSFQARQDDELNLEKGDIV--IIHEKKEEGWWFGSLNGKKGHFPAAYVEEL 495
Score = 47.0 bits (110), Expect = 5e-05
Identities = 21/50 (42%), Positives = 33/50 (66%), Gaps = 1/50 (2%)
Query: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEI 57
Y + A DDEL + G+I+ + + +EEGW G LNG++G FP +V+E+
Sbjct: 447 YSFQARQDDELNLEKGDIVI-IHEKKEEGWWFGSLNGKKGHFPAAYVEEL 495
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.131 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,473,962
Number of Sequences: 37866
Number of extensions: 1645012
Number of successful extensions: 19391
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 377
Number of HSP's successfully gapped in prelim test: 840
Number of HSP's that attempted gapping in prelim test: 11442
Number of HSP's gapped (non-prelim): 5776
length of query: 639
length of database: 18,247,518
effective HSP length: 109
effective length of query: 530
effective length of database: 14,120,124
effective search space: 7483665720
effective search space used: 7483665720
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.