Guide to the Human Genome
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Search of human proteins with 186928847

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|186928847 cirhin [Homo sapiens]
         (686 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|186928847 cirhin [Homo sapiens]                                   1397   0.0  
gi|13376840 WD repeat domain 61 [Homo sapiens]                         58   3e-08
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]    57   4e-08
gi|147904340 WD repeat domain 82 [Homo sapiens]                        50   7e-06
gi|19913369 transducin beta-like 3 [Homo sapiens]                      50   9e-06
gi|21071067 TBP-associated factor 5 [Homo sapiens]                     49   1e-05
gi|34915994 transducin-like enhancer protein 4 [Homo sapiens]          49   2e-05
gi|34485720 echinoderm microtubule associated protein like 5 [Ho...    48   3e-05
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     47   6e-05
gi|16418439 WD repeat and FYVE domain containing 2 [Homo sapiens]      47   8e-05
gi|5803221 WD repeat-containing protein 3 [Homo sapiens]               46   1e-04
gi|21541824 transducin-like enhancer protein 1 [Homo sapiens]          46   1e-04
gi|59938780 WD repeat domain 31 isoform 1 [Homo sapiens]               45   2e-04
gi|21687048 WD repeat domain 31 isoform 3 [Homo sapiens]               45   2e-04
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     45   2e-04
gi|190684671 mitogen-activated protein kinase binding protein 1 ...    44   4e-04
gi|190684677 mitogen-activated protein kinase binding protein 1 ...    44   4e-04
gi|89886480 zinedin isoform 2 [Homo sapiens]                           44   5e-04
gi|89886477 zinedin isoform 1 [Homo sapiens]                           44   5e-04
gi|157384986 transducin-like enhancer protein 3 isoform b [Homo ...    44   5e-04
gi|157384984 transducin-like enhancer protein 3 isoform c [Homo ...    44   5e-04
gi|157384982 transducin-like enhancer protein 3 isoform a [Homo ...    44   5e-04
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H...    44   6e-04
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H...    44   6e-04
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H...    44   6e-04
gi|51242945 striatin, calmodulin binding protein [Homo sapiens]        43   0.001
gi|45594312 TNF receptor-associated factor 7 [Homo sapiens]            42   0.001
gi|5901892 WD repeat and HMG-box DNA binding protein 1 isoform 1...    42   0.001
gi|75677340 WD repeat domain, phosphoinositide interacting 2 iso...    42   0.002
gi|75677331 WD repeat domain, phosphoinositide interacting 2 iso...    42   0.002

>gi|186928847 cirhin [Homo sapiens]
          Length = 686

 Score = 1397 bits (3617), Expect = 0.0
 Identities = 686/686 (100%), Positives = 686/686 (100%)

Query: 1   MGEFKVHRVRFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHES 60
           MGEFKVHRVRFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHES
Sbjct: 1   MGEFKVHRVRFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHES 60

Query: 61  RATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGC 120
           RATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGC
Sbjct: 61  RATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGC 120

Query: 121 EDGSVKLFQITPDKIQFERNFDRQKSRILSLSWHPSGTHIAAGSIDYISVFDVKSGSAVH 180
           EDGSVKLFQITPDKIQFERNFDRQKSRILSLSWHPSGTHIAAGSIDYISVFDVKSGSAVH
Sbjct: 121 EDGSVKLFQITPDKIQFERNFDRQKSRILSLSWHPSGTHIAAGSIDYISVFDVKSGSAVH 180

Query: 181 KMIVDRQYMGVSKRKCIVWGVAFLSDGTIISVDSAGKVQFWDSATGTLVKSHLIANADVQ 240
           KMIVDRQYMGVSKRKCIVWGVAFLSDGTIISVDSAGKVQFWDSATGTLVKSHLIANADVQ
Sbjct: 181 KMIVDRQYMGVSKRKCIVWGVAFLSDGTIISVDSAGKVQFWDSATGTLVKSHLIANADVQ 240

Query: 241 SIAVADQEDSFVVGTAEGTVFHFQLVPVTSNSSEKQWVRTKPFQHHTHDVRTVAHSPTAL 300
           SIAVADQEDSFVVGTAEGTVFHFQLVPVTSNSSEKQWVRTKPFQHHTHDVRTVAHSPTAL
Sbjct: 241 SIAVADQEDSFVVGTAEGTVFHFQLVPVTSNSSEKQWVRTKPFQHHTHDVRTVAHSPTAL 300

Query: 301 ISGGTDTHLVFRPLMEKVEVKNYDAALRKITFPHRCLISCSKKRQLLLFQFAHHLELWRL 360
           ISGGTDTHLVFRPLMEKVEVKNYDAALRKITFPHRCLISCSKKRQLLLFQFAHHLELWRL
Sbjct: 301 ISGGTDTHLVFRPLMEKVEVKNYDAALRKITFPHRCLISCSKKRQLLLFQFAHHLELWRL 360

Query: 361 GSTVATGKNGDTLPLSKNADHLLHLKTKGPENIICSCISPCGSWIAYSTVSRFFLYRLNY 420
           GSTVATGKNGDTLPLSKNADHLLHLKTKGPENIICSCISPCGSWIAYSTVSRFFLYRLNY
Sbjct: 361 GSTVATGKNGDTLPLSKNADHLLHLKTKGPENIICSCISPCGSWIAYSTVSRFFLYRLNY 420

Query: 421 EHDNISLKRVSKMPAFLRSALQILFSEDSTKLFVASNQGALHIVQLSGGSFKHLHAFQPQ 480
           EHDNISLKRVSKMPAFLRSALQILFSEDSTKLFVASNQGALHIVQLSGGSFKHLHAFQPQ
Sbjct: 421 EHDNISLKRVSKMPAFLRSALQILFSEDSTKLFVASNQGALHIVQLSGGSFKHLHAFQPQ 480

Query: 481 SGTVEAMCLLAVSPDGNWLAASGTSAGVHVYNVKQLKLHCTVPAYNFPVTAMAIAPNTNN 540
           SGTVEAMCLLAVSPDGNWLAASGTSAGVHVYNVKQLKLHCTVPAYNFPVTAMAIAPNTNN
Sbjct: 481 SGTVEAMCLLAVSPDGNWLAASGTSAGVHVYNVKQLKLHCTVPAYNFPVTAMAIAPNTNN 540

Query: 541 LVIAHSDQQVFEYSIPDKQYTDWSRTVQKQGFHHLWLQRDTPITHISFHPKRPMHILLHD 600
           LVIAHSDQQVFEYSIPDKQYTDWSRTVQKQGFHHLWLQRDTPITHISFHPKRPMHILLHD
Sbjct: 541 LVIAHSDQQVFEYSIPDKQYTDWSRTVQKQGFHHLWLQRDTPITHISFHPKRPMHILLHD 600

Query: 601 AYMFCIIDKSLPLPNDKTLLYNPFPPTNESDVIRRRTAHAFKISKIYKPLLFMDLLDERT 660
           AYMFCIIDKSLPLPNDKTLLYNPFPPTNESDVIRRRTAHAFKISKIYKPLLFMDLLDERT
Sbjct: 601 AYMFCIIDKSLPLPNDKTLLYNPFPPTNESDVIRRRTAHAFKISKIYKPLLFMDLLDERT 660

Query: 661 LVAVERPLDDIIAQLPPPIKKKKFGT 686
           LVAVERPLDDIIAQLPPPIKKKKFGT
Sbjct: 661 LVAVERPLDDIIAQLPPPIKKKKFGT 686


>gi|13376840 WD repeat domain 61 [Homo sapiens]
          Length = 305

 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 52/191 (27%), Positives = 82/191 (42%), Gaps = 41/191 (21%)

Query: 76  SAGLNGEIMEYDLQALNIKYAMDAFGGPI--WSMAASPSGSQLLVGCEDGSVKLFQITPD 133
           S+ L+  I  +DL+  N K       GP+  W++A SP    L  G   G V +F +   
Sbjct: 81  SSSLDAHIRLWDLE--NGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESG 138

Query: 134 KIQFERNFDRQKSRILSLSWHPSGTHIAAGSID-YISVFDVKSGSAVHKM---------- 182
           K ++  + D +   ILS+++ P G ++A+G+ID  I++FD+ +G  +H +          
Sbjct: 139 KKEY--SLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSL 196

Query: 183 -------------------IVDRQYMG----VSKRKCIVWGVAFLSDGT-IISVDSAGKV 218
                              I D Q+      +S     V  VAF  D T  +S  S   V
Sbjct: 197 TFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSV 256

Query: 219 QFWDSATGTLV 229
           + WD  T T V
Sbjct: 257 KVWDVGTRTCV 267



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 45/204 (22%), Positives = 94/204 (46%), Gaps = 16/204 (7%)

Query: 22  VAYNNQSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHESRATEALCWA-EGQRLFSAGLN 80
           +A++  S  LA     G V I+ + +   ++++      +   ++ ++ +G+ L S  ++
Sbjct: 112 LAFSPDSQYLATGTHVGKVNIFGVESG--KKEYSLDTRGKFILSIAYSPDGKYLASGAID 169

Query: 81  GEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQITPDKIQFERN 140
           G I  +D+    + + ++    PI S+  SP    L+   +DG +K++ +          
Sbjct: 170 GIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDV--QHANLAGT 227

Query: 141 FDRQKSRILSLSWHPSGTHIAAGSID-YISVFDVKSGSAVHKMIVDRQYMGVSKRKCIVW 199
                S +L++++ P  TH  + S D  + V+DV + + VH    D Q          VW
Sbjct: 228 LSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFF-DHQDQ--------VW 278

Query: 200 GVAFLSDGT-IISVDSAGKVQFWD 222
           GV +  +G+ I+SV    ++  +D
Sbjct: 279 GVKYNGNGSKIVSVGDDQEIHIYD 302



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 43/187 (22%), Positives = 80/187 (42%), Gaps = 13/187 (6%)

Query: 372 TLPLSKNADHLLHLKTKGPEN---IICSCISPCGSW-IAYSTVSRFFLYRLNYEHDNI-- 425
           TLP++ ++    H++    EN   I      P  +W +A+S  S++     +    NI  
Sbjct: 75  TLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFG 134

Query: 426 --SLKRVSKMPAFLRSALQILFSEDSTKLFVASNQGALHIVQLSGGSFKHLHAFQPQSGT 483
             S K+   +    +  L I +S D   L   +  G ++I  ++ G  K LH  +  +  
Sbjct: 135 VESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATG--KLLHTLEGHAMP 192

Query: 484 VEAMCLLAVSPDGNWLAASGTSAGVHVYNVKQLKLHCTVPAYNFPVTAMAIAPNTNNLVI 543
           + +   L  SPD   L  +     + +Y+V+   L  T+  +   V  +A  P+  + V 
Sbjct: 193 IRS---LTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVS 249

Query: 544 AHSDQQV 550
           + SD+ V
Sbjct: 250 SSSDKSV 256



 Score = 38.5 bits (88), Expect = 0.021
 Identities = 33/155 (21%), Positives = 65/155 (41%), Gaps = 4/155 (2%)

Query: 19  IRCVAYNNQSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHESRATEALCWAEGQRLFSAG 78
           I  +AY+     LA    DG + I++++          GH           + Q L +A 
Sbjct: 151 ILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHT-LEGHAMPIRSLTFSPDSQLLVTAS 209

Query: 79  LNGEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQITPDKIQFE 138
            +G I  YD+Q  N+   +      + ++A  P  +  +    D SVK++ +   +    
Sbjct: 210 DDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDV-GTRTCVH 268

Query: 139 RNFDRQKSRILSLSWHPSGTHI-AAGSIDYISVFD 172
             FD Q  ++  + ++ +G+ I + G    I ++D
Sbjct: 269 TFFDHQ-DQVWGVKYNGNGSKIVSVGDDQEIHIYD 302


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 38/153 (24%), Positives = 75/153 (49%), Gaps = 9/153 (5%)

Query: 37  DGTVEIYNLSANYFQEKFFPGHESRATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKYA 96
           DGTV+++++      + F   ++  A      ++  ++ S G++ +I  +DL+   + Y 
Sbjct: 173 DGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSD--QIISGGIDNDIKVWDLRQNKLTYT 230

Query: 97  MDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQITPDKIQ------FERNFDRQKSRILS 150
           M      +  ++ S  GS LL    D +V+++ + P   +      F+ N    +  +L 
Sbjct: 231 MRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLR 290

Query: 151 LSWHPSGTHIAAGSID-YISVFDVKSGSAVHKM 182
            SW P G+ IAAGS D ++ V+D  S   ++K+
Sbjct: 291 CSWSPDGSKIAAGSADRFVYVWDTTSRRILYKL 323



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 37/167 (22%), Positives = 73/167 (43%), Gaps = 7/167 (4%)

Query: 19  IRCVAYNNQSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHESRATEALCWAEGQRLFSAG 78
           + C  ++   + LA +  D  + ++N+  +        GH     E     +G  LFSA 
Sbjct: 69  VYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSAS 128

Query: 79  LNGEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLL-VGCEDGSVKLFQITPD-KIQ 136
            +  +  +D +       +      + S   +  G QL+  G +DG+VKL+ I     IQ
Sbjct: 129 TDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQ 188

Query: 137 FERNFDRQKSRILSLSWHPSGTHIAAGSIDY-ISVFDVKSGSAVHKM 182
             +N      ++L+++++ +   I +G ID  I V+D++     + M
Sbjct: 189 TFQN----TYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTM 231


>gi|147904340 WD repeat domain 82 [Homo sapiens]
          Length = 313

 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 52/220 (23%), Positives = 86/220 (39%), Gaps = 18/220 (8%)

Query: 18  GIRCVAYNNQSNRLAVS--RTDGTVEIYNLSANYFQEKFFPGHESRATEALCWAEGQRLF 75
           G+  + Y + +N +  S  + D T+   +L  N +  ++FPGH  R              
Sbjct: 65  GVDLIRYTHAANTVVYSSNKIDDTIRYLSLHDNKYI-RYFPGHSKRVVALSMSPVDDTFI 123

Query: 76  SAGLNGEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQITP-DK 134
           S  L+  I  +DL++ N +  M   G P+ S    P G     G     VKL+ +   DK
Sbjct: 124 SGSLDKTIRLWDLRSPNCQGLMHLQGKPVCSF--DPEGLIFAAGVNSEMVKLYDLRSFDK 181

Query: 135 ---IQFERNFDRQKSRILSLSWHPSGTHIAAGSI-DYISVFDVKSGSAVHKMIVDRQYMG 190
                F+  +DR       L +   G  I   +   +I + D   G  +H       + G
Sbjct: 182 GPFATFKMQYDR-TCEWTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMH------TFGG 234

Query: 191 VSKRKCIVWGVAFLSDGTIISVDSA-GKVQFWDSATGTLV 229
            +  K +    +F  D   I + S  GK+  W+  +G  V
Sbjct: 235 YANSKAVTLEASFTPDSQFIMIGSEDGKIHVWNGESGIKV 274


>gi|19913369 transducin beta-like 3 [Homo sapiens]
          Length = 808

 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 35/149 (23%), Positives = 67/149 (44%), Gaps = 10/149 (6%)

Query: 1   MGEFKVHRVRFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHES 60
           +G F  HR         G+ CV ++     LA +  DGT++++ L  ++   K F GH++
Sbjct: 514 LGVFSGHR--------RGLWCVQFSPMDQVLATASADGTIKLWALQ-DFSCLKTFEGHDA 564

Query: 61  RATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGC 120
              +    + G +L S+G +G +  + ++       +DA    +W +  S      L G 
Sbjct: 565 SVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGA 624

Query: 121 EDGSVKLFQITPDKIQFERNFDRQKSRIL 149
            D  V L++   +  Q E    RQ+ +++
Sbjct: 625 SDSRVILWKDVTEAEQAEEQ-ARQEEQVV 652


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 57/261 (21%), Positives = 99/261 (37%), Gaps = 14/261 (5%)

Query: 2   GEFKVHRVRFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHESR 61
           G F    VR ++  P  +R V   +  + L    +D  +E         + K   GH   
Sbjct: 487 GGFADSTVRVWSVTPKKLRSVKQASDLS-LIDKESDDVLERIMDEKTASELKILYGHSGP 545

Query: 62  ATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCE 121
              A    +   L S+  +G +  + LQ             P+W    SP G   + G  
Sbjct: 546 VYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGH 605

Query: 122 DGSVKLFQITPDKIQFERNFDRQKSRILSLSWHPSGTHIAAGSID-YISVFDVKSGSAVH 180
           D   +L+    D  Q  R F    + +    +HP+  ++A GS D  + ++DV +G+ V 
Sbjct: 606 DRVARLW--ATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCV- 662

Query: 181 KMIVDRQYMGVSKRKCIVWGVAFLSDGTIISVDSA-GKVQFWDSATGTLVKSHLIANADV 239
                R + G    K  +  + F  +G  ++  +  G+V  WD   G +V         V
Sbjct: 663 -----RIFTG---HKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTV 714

Query: 240 QSIAVADQEDSFVVGTAEGTV 260
            S+  +   +    G+ + TV
Sbjct: 715 CSLRFSRDGEILASGSMDNTV 735


>gi|34915994 transducin-like enhancer protein 4 [Homo sapiens]
          Length = 773

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 47/183 (25%), Positives = 85/183 (46%), Gaps = 21/183 (11%)

Query: 36  TDGTVEIYNLSANYFQEKFFPGHESRATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKY 95
           +DG + +++L  N    + F GH   A+      +G +L++ GL+  +  +DL+    + 
Sbjct: 597 SDGNIAVWDLH-NQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLRE-GRQL 654

Query: 96  AMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQIT-PDKIQFERNFDRQKSRILSLSWH 154
               F   I+S+   P+G  L VG E+ +V++  +T PDK Q   +    +S +LSL + 
Sbjct: 655 QQHDFTSQIFSLGYCPTGEWLAVGMENSNVEVLHVTKPDKYQLHLH----ESCVLSLKFA 710

Query: 155 PSGTHIAAGSIDYI----------SVFDVKSGSAVHK--MIVDRQYM--GVSKRKCIVWG 200
             G    +   D +          S+F  K  S+V    + VD +Y+  G   +K  V+ 
Sbjct: 711 HCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYE 770

Query: 201 VAF 203
           V +
Sbjct: 771 VIY 773


>gi|34485720 echinoderm microtubule associated protein like 5 [Homo
            sapiens]
          Length = 1977

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 41/173 (23%), Positives = 74/173 (42%), Gaps = 16/173 (9%)

Query: 57   GHESRATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKYAMDAF-GGPIWSMAASPSGSQ 115
            G  +    ++C  +G+ L     N EI+E   +       ++    GPIW +A  PS   
Sbjct: 1658 GQATDCVRSVCRGKGKILVGTR-NAEIIEVGEKNAACNILVNGHVDGPIWGLATHPSRDF 1716

Query: 116  LLVGCEDGSVKLFQITPDKIQFERNFDRQKSRILSLSWHPSGTHIAAGSIDYISVFDVKS 175
             L   EDG+V+L+ I   K+  + N         ++ + P G  +A G         +K+
Sbjct: 1717 FLSAAEDGTVRLWDIADKKMLNKVNLGHAAR---TVCYSPEGDMVAIG---------MKN 1764

Query: 176  GSAVHKMIVDRQYMGVSK-RKCIVWGVAFLSDGTIISVDSA-GKVQFWDSATG 226
            G  +  ++   +  G  + R+C +  + F  D   ++V S+   V F+D   G
Sbjct: 1765 GEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLG 1817



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 38/139 (27%), Positives = 62/139 (44%), Gaps = 17/139 (12%)

Query: 110  SPSGSQLLVGCEDGSVKLFQITPDKIQFERNFDRQKSRILSLSWHP-SGTHIAAGSID-Y 167
            SP G  L VG  DGS        D ++   +F  +K  I  + + P SG ++A  S D +
Sbjct: 1049 SPDGKALAVGLNDGS--FLMANADTLEDLVSFHHRKDMISDIRFSPGSGKYLAVASHDSF 1106

Query: 168  ISVFDVKSGSAVHKMIVDRQYMGVSKRKCIVWGVAFLSDGTIISVDSAGKVQ-FWDSATG 226
            I +++V S   V        Y+       I W +     G ++ V++  K Q F+++  G
Sbjct: 1107 IDIYNVMSSKRVGICKGATSYI-----THIDWDIR----GKLLQVNTGAKEQLFFEAPRG 1157

Query: 227  TLVKSHLIANADVQSIAVA 245
               K   I + +V+ IA A
Sbjct: 1158 ---KKQTIPSVEVEKIAWA 1173


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 29/116 (25%), Positives = 56/116 (48%), Gaps = 2/116 (1%)

Query: 19  IRCVAYNNQSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHESRATEALCWAEGQRLFSAG 78
           +RC+ ++     LA +  D TV++++L+A     +F PGH               L S  
Sbjct: 150 VRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEF-PGHTGPVNVVEFHPNEYLLASGS 208

Query: 79  LNGEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQITPDK 134
            +  I  +DL+   +   ++   GP+ S+  +P G  L  GC+D S++++   P++
Sbjct: 209 SDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPER 263



 Score = 38.1 bits (87), Expect = 0.027
 Identities = 30/150 (20%), Positives = 59/150 (39%), Gaps = 3/150 (2%)

Query: 17  SGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHESRATEALCWAEGQRLFS 76
           S +  V  N     +      G++ +++L A         GH++          G+ + S
Sbjct: 64  SPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLM-GHKANICSLDFHPYGEFVAS 122

Query: 77  AGLNGEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQITPDKIQ 136
              +  I  +D++     +        +  +  SP G  L    +D +VKL+ +T  K+ 
Sbjct: 123 GSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMM 182

Query: 137 FERNFDRQKSRILSLSWHPSGTHIAAGSID 166
            E  F      +  + +HP+   +A+GS D
Sbjct: 183 SE--FPGHTGPVNVVEFHPNEYLLASGSSD 210



 Score = 37.7 bits (86), Expect = 0.036
 Identities = 20/69 (28%), Positives = 33/69 (47%)

Query: 482 GTVEAMCLLAVSPDGNWLAASGTSAGVHVYNVKQLKLHCTVPAYNFPVTAMAIAPNTNNL 541
           G  +A+  L  SPDG WLA++     V ++++   K+    P +  PV  +   PN   L
Sbjct: 145 GHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLL 204

Query: 542 VIAHSDQQV 550
               SD+ +
Sbjct: 205 ASGSSDRTI 213



 Score = 35.4 bits (80), Expect = 0.18
 Identities = 29/121 (23%), Positives = 51/121 (42%), Gaps = 3/121 (2%)

Query: 57  GHESRATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQL 116
           GH S           + + +   +G I  +DL+A  I   +      I S+   P G  +
Sbjct: 61  GHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFV 120

Query: 117 LVGCEDGSVKLFQITPDKIQFERNFDRQKSRILSLSWHPSGTHIAAGSIDY-ISVFDVKS 175
             G +D ++KL+ I      F      Q  R L  S  P G  +A+ + D+ + ++D+ +
Sbjct: 121 ASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFS--PDGKWLASAADDHTVKLWDLTA 178

Query: 176 G 176
           G
Sbjct: 179 G 179


>gi|16418439 WD repeat and FYVE domain containing 2 [Homo sapiens]
          Length = 400

 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 40/181 (22%), Positives = 83/181 (45%), Gaps = 21/181 (11%)

Query: 12  FNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYFQ---EKFFPGHESRATEALCW 68
           ++ +PS   C+++N ++ RL++   +GT+  + LS +Y +    K +  H+SR T  L  
Sbjct: 64  YHAMPSPCSCMSFNPETRRLSIGLDNGTISEFILSEDYNKMTPVKNYQAHQSRVTMILFV 123

Query: 69  AEGQRLFSAGLNGEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQ-------LLVGCE 121
            E + + S G + +       A +   +    GG  +  +A  SG Q       + +G  
Sbjct: 124 LELEWVLSTGQDKQF------AWHCSESGQRLGG--YRTSAVASGLQFDVETRHVFIGDH 175

Query: 122 DGSVKLFQITPDKIQFERNFDRQKSRILSLSWHPSGTHIAAGSIDY-ISVFDV--KSGSA 178
            G V + ++  +       F      + +L W P    + +GS D+ + ++D+  + G+A
Sbjct: 176 SGQVTILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTA 235

Query: 179 V 179
           +
Sbjct: 236 I 236


>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
          Length = 943

 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 49/188 (26%), Positives = 85/188 (45%), Gaps = 24/188 (12%)

Query: 65  ALC--WAEGQRLFSAGLN-GEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCE 121
           ALC  +  G R    G   G++  YDL + N+   +DA  G +WSM+ SP     + G  
Sbjct: 457 ALCSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGA 516

Query: 122 DGSVKL--FQITPDKIQFERNFDRQKSR-------ILSLSWHPSGTHIAAGSID-YISVF 171
           D SVK   F++  D+   ++    +++R       +L +S+ P+   +A   +D  + +F
Sbjct: 517 DKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIF 576

Query: 172 DVKSGSAVHKMIVDRQYMGVSKRKCIVWGVAFLSDGTIISVDSAGK-VQFWDSATGTLVK 230
            V +          + ++ +   K  V  +    DG +I+  SA + V+ W    G   K
Sbjct: 577 YVDT---------LKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHK 627

Query: 231 SHLIANAD 238
           S L A+ D
Sbjct: 628 S-LFAHDD 634



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 34/152 (22%), Positives = 68/152 (44%), Gaps = 11/152 (7%)

Query: 107 MAASPSGSQLLVGCEDGSVKLFQITPDKIQFERNFDRQKSRILSLSWHPSGTHIAAGSID 166
           +  SP G  L VG EDGS+++F +     +    F+  K+ I +L +   G  +A+GS D
Sbjct: 71  LCPSPDGLHLAVGYEDGSIRIFSLLSG--EGNVTFNGHKAAITTLKYDQLGGRLASGSKD 128

Query: 167 Y-ISVFDVKSGSAVHKMIVDRQYMGVSKRKCIVWGVAFLSDGTIISVDSAGKVQFWDSAT 225
             I V+DV + S ++++           +  I   +       +++      V++WD  T
Sbjct: 129 TDIIVWDVINESGLYRL--------KGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDT 180

Query: 226 GTLVKSHLIANADVQSIAVADQEDSFVVGTAE 257
               K+ +    +V  + +  +E   + G ++
Sbjct: 181 QHCFKTMVGHRTEVWGLVLLSEEKRLITGASD 212



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 28/126 (22%), Positives = 55/126 (43%), Gaps = 3/126 (2%)

Query: 21  CVAYNNQSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHESRATEALCWAEGQRLFSAGLN 80
           C+  ++    +A    D  V+I+ L      +  F  H+          +    F+AG +
Sbjct: 596 CMDISHDGALIATGSADRNVKIWGLDFGDCHKSLF-AHDDSVMYLQFVPKSHLFFTAGKD 654

Query: 81  GEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQIT--PDKIQFE 138
            +I ++D         ++     IW +A SPSG  ++    D S++L++ T  P  ++ E
Sbjct: 655 HKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLILEEE 714

Query: 139 RNFDRQ 144
           R  +R+
Sbjct: 715 REMERE 720



 Score = 35.4 bits (80), Expect = 0.18
 Identities = 25/121 (20%), Positives = 52/121 (42%), Gaps = 5/121 (4%)

Query: 12  FNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNL--SANYFQEKFFPGHESRATEALCWA 69
           FN   + I  + Y+    RLA    D  + ++++   +  ++ K   GH+   T+AL   
Sbjct: 103 FNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLK---GHKDAITQALFLR 159

Query: 70  EGQRLFSAGLNGEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQ 129
           E   L ++G +  +  +DL   +    M      +W +       +L+ G  D  ++++ 
Sbjct: 160 EKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWD 219

Query: 130 I 130
           I
Sbjct: 220 I 220



 Score = 35.4 bits (80), Expect = 0.18
 Identities = 23/94 (24%), Positives = 50/94 (53%), Gaps = 2/94 (2%)

Query: 206 DGTIISVDSAGKVQFWDSATGTLVKSHLIANADVQSIAVADQEDSFVVGTAEGTV--FHF 263
           D  ++     GK+Q +D A+G L+++    +  + S++++  +  FV G A+ +V  + F
Sbjct: 466 DRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDF 525

Query: 264 QLVPVTSNSSEKQWVRTKPFQHHTHDVRTVAHSP 297
           +LV   +++ ++  V+         DV  V++SP
Sbjct: 526 ELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSP 559


>gi|21541824 transducin-like enhancer protein 1 [Homo sapiens]
          Length = 770

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 46/183 (25%), Positives = 83/183 (45%), Gaps = 21/183 (11%)

Query: 36  TDGTVEIYNLSANYFQEKFFPGHESRATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKY 95
           +DG + +++L  N    + F GH   A+      +G +L++ GL+  +  +DL+    + 
Sbjct: 594 SDGNIAVWDLH-NQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLRE-GRQL 651

Query: 96  AMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQIT-PDKIQFERNFDRQKSRILSLSWH 154
               F   I+S+   P+G  L VG E  +V++  +  PDK Q   +    +S +LSL + 
Sbjct: 652 QQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLH----ESCVLSLKFA 707

Query: 155 PSGTHIAAGSIDYI----------SVFDVKSGSAVHK--MIVDRQYM--GVSKRKCIVWG 200
             G    +   D +          S+F  K  S+V    + VD +Y+  G   +K  V+ 
Sbjct: 708 YCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYE 767

Query: 201 VAF 203
           V +
Sbjct: 768 VIY 770


>gi|59938780 WD repeat domain 31 isoform 1 [Homo sapiens]
          Length = 367

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 52/214 (24%), Positives = 82/214 (38%), Gaps = 12/214 (5%)

Query: 3   EFKVHRVRFFNYVPSGIRCVAYNNQSNR-LAVSR-TDGTVEIYNLSANYFQEKFFPGHES 60
           E ++    F  Y P+ +  V+     N  L VS   D TV  YN       ++F  GHE 
Sbjct: 46  EERIQTKAFQEYSPAHMDTVSVVAALNSDLCVSGGKDKTVVAYNWKTGNVVKRF-KGHEH 104

Query: 61  RATEALCWAEGQRLFSAGLNGEIMEYDLQ-ALNIKYAMDAFGGPIWSMAASPSGSQLLVG 119
             T+  C  +  + FSA  +  +M +DL  +   +  +      +  +A SP  SQL  G
Sbjct: 105 EITKVACIPKSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTG 164

Query: 120 CEDGSVKLFQITPDKIQFERNFDRQKSRILSLSWHPSGTHIAAGSIDYISVFDVKSGSAV 179
             D ++ L+ +     Q        ++ +  L W P   +I   S D         G  V
Sbjct: 165 SRDNTLLLWDVVTG--QSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQV 222

Query: 180 HKMIVDRQY------MGVSKRKCIVWGVAFLSDG 207
             M   +Q+      + V   KCI     F  +G
Sbjct: 223 AHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEG 256


>gi|21687048 WD repeat domain 31 isoform 3 [Homo sapiens]
          Length = 366

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 52/214 (24%), Positives = 82/214 (38%), Gaps = 12/214 (5%)

Query: 3   EFKVHRVRFFNYVPSGIRCVAYNNQSNR-LAVSR-TDGTVEIYNLSANYFQEKFFPGHES 60
           E ++    F  Y P+ +  V+     N  L VS   D TV  YN       ++F  GHE 
Sbjct: 45  EERIQTKAFQEYSPAHMDTVSVVAALNSDLCVSGGKDKTVVAYNWKTGNVVKRF-KGHEH 103

Query: 61  RATEALCWAEGQRLFSAGLNGEIMEYDLQ-ALNIKYAMDAFGGPIWSMAASPSGSQLLVG 119
             T+  C  +  + FSA  +  +M +DL  +   +  +      +  +A SP  SQL  G
Sbjct: 104 EITKVACIPKSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTG 163

Query: 120 CEDGSVKLFQITPDKIQFERNFDRQKSRILSLSWHPSGTHIAAGSIDYISVFDVKSGSAV 179
             D ++ L+ +     Q        ++ +  L W P   +I   S D         G  V
Sbjct: 164 SRDNTLLLWDVVTG--QSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQV 221

Query: 180 HKMIVDRQY------MGVSKRKCIVWGVAFLSDG 207
             M   +Q+      + V   KCI     F  +G
Sbjct: 222 AHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEG 255


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 52/229 (22%), Positives = 94/229 (41%), Gaps = 35/229 (15%)

Query: 53  KFFPGHESRATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKYAMDAFGGPIWSMAASPS 112
           K   GH          A+   L S   +  I  +DL +            P+W +  SP 
Sbjct: 336 KILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPY 395

Query: 113 GSQLLVGCEDGSVKLFQITPDKIQFERNFDRQKSRILSLSWHPSGTHIAAGSID-YISVF 171
                 G  D + +L+    D+    R +    + +  + +HP+  ++A GS D  + ++
Sbjct: 396 SLYFASGSHDRTARLWSF--DRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLW 453

Query: 172 DVKSGSAVHKMIVDRQYMGVSKRKCIVWGVAFLSDGTIISVDSAG---KVQFWDSATGTL 228
             + G++V      R + G    +  V  +AF  +G  ++  SAG   +++ WD A+GTL
Sbjct: 454 SAQQGNSV------RLFTG---HRGPVLSLAFSPNGKYLA--SAGEDQRLKLWDLASGTL 502

Query: 229 VK-----------------SHLIANADV-QSIAVADQEDSFVVGTAEGT 259
            K                 S LIA+A +  S+ V D  +++    A+G+
Sbjct: 503 YKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGS 551



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 28/112 (25%), Positives = 47/112 (41%), Gaps = 1/112 (0%)

Query: 19  IRCVAYNNQSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHESRATEALCWAEGQRLFSAG 78
           + CV ++  SN LA   TD TV +++        + F GH            G+ L SAG
Sbjct: 429 VDCVKFHPNSNYLATGSTDKTVRLWSAQQGN-SVRLFTGHRGPVLSLAFSPNGKYLASAG 487

Query: 79  LNGEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQI 130
            +  +  +DL +  +   +      I S+  SP    +     D SV+++ I
Sbjct: 488 EDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI 539



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 19/81 (23%), Positives = 37/81 (45%)

Query: 470 SFKHLHAFQPQSGTVEAMCLLAVSPDGNWLAASGTSAGVHVYNVKQLKLHCTVPAYNFPV 529
           SF   +  +  +G +  +  +   P+ N+LA   T   V +++ +Q         +  PV
Sbjct: 412 SFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPV 471

Query: 530 TAMAIAPNTNNLVIAHSDQQV 550
            ++A +PN   L  A  DQ++
Sbjct: 472 LSLAFSPNGKYLASAGEDQRL 492


>gi|190684671 mitogen-activated protein kinase binding protein 1
           isoform a [Homo sapiens]
          Length = 1508

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 53/240 (22%), Positives = 96/240 (40%), Gaps = 28/240 (11%)

Query: 1   MGEFKVHRVRFFNYV------PSGIRCVAYNNQSNRL---AVSRTDGTVEIYNLSANYFQ 51
           MG  +VH ++  + +       S I C+ Y+     L   A +  D  + + +    Y  
Sbjct: 494 MGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSL 553

Query: 52  EKFFPGHESRATEA-LCWAEGQ-RLFSAGLNGEIMEYDLQALN--IKYAMDAF---GGPI 104
           ++    H S  T      ++GQ R+ S G +  I     Q     +++           +
Sbjct: 554 QQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDGVQFTRTHHVVRKTTL 613

Query: 105 WSMAASPSGSQLLVGCEDGSVKLFQITPDK-IQFERNFDRQKSRILSLSWHPSGTHIAAG 163
           + M   PS     +GC+D ++++F I+  K  +  +    +   ++ +   PSG +IA  
Sbjct: 614 YDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATS 673

Query: 164 SID-YISVFDVKSGSAVHKMIVDRQYMGVSKRKCIVWGVAFLSD-GTIISVDSAGKVQFW 221
             D  +S+FD  SG  V  M    +         IV G+ F +D   +ISV     +  W
Sbjct: 674 CSDKNLSIFDFSSGECVATMFGHSE---------IVTGMKFSNDCKHLISVSGDSCIFVW 724


>gi|190684677 mitogen-activated protein kinase binding protein 1
           isoform b [Homo sapiens]
          Length = 1514

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 53/240 (22%), Positives = 96/240 (40%), Gaps = 28/240 (11%)

Query: 1   MGEFKVHRVRFFNYV------PSGIRCVAYNNQSNRL---AVSRTDGTVEIYNLSANYFQ 51
           MG  +VH ++  + +       S I C+ Y+     L   A +  D  + + +    Y  
Sbjct: 500 MGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSL 559

Query: 52  EKFFPGHESRATEA-LCWAEGQ-RLFSAGLNGEIMEYDLQALN--IKYAMDAF---GGPI 104
           ++    H S  T      ++GQ R+ S G +  I     Q     +++           +
Sbjct: 560 QQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDGVQFTRTHHVVRKTTL 619

Query: 105 WSMAASPSGSQLLVGCEDGSVKLFQITPDK-IQFERNFDRQKSRILSLSWHPSGTHIAAG 163
           + M   PS     +GC+D ++++F I+  K  +  +    +   ++ +   PSG +IA  
Sbjct: 620 YDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATS 679

Query: 164 SID-YISVFDVKSGSAVHKMIVDRQYMGVSKRKCIVWGVAFLSD-GTIISVDSAGKVQFW 221
             D  +S+FD  SG  V  M    +         IV G+ F +D   +ISV     +  W
Sbjct: 680 CSDKNLSIFDFSSGECVATMFGHSE---------IVTGMKFSNDCKHLISVSGDSCIFVW 730


>gi|89886480 zinedin isoform 2 [Homo sapiens]
          Length = 760

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 53/262 (20%), Positives = 107/262 (40%), Gaps = 32/262 (12%)

Query: 18  GIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYFQEK----------FFPGHESRATEALC 67
           GIR +A+++  + L  +  DGT++++NL      +K           F  H         
Sbjct: 447 GIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAM 506

Query: 68  WAEGQRLFSAGLNGEIMEYDLQALN-----------IKYAMDAFGGPIWSMAASPSGSQL 116
            +  +  +S G +  I  + +  L+           + + ++  G  +W +A SP+  +L
Sbjct: 507 GSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRL 566

Query: 117 LVGCEDGSVKLFQITPDKIQFERNFDRQKSRILSLSWHPSGT---HIAAG--SIDYISVF 171
                DG+V+++  +         F       +  S   + T   HI A   S D + ++
Sbjct: 567 ASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTV-LY 625

Query: 172 DVKSGSAVHKMIVDRQYMGVSKRKCIVWGVAFLSDGTIISVDSAGKVQFWDSATGTLVKS 231
           D++ GSA    ++  +  G S    I   V+  +    I+      ++F D+ TG  V S
Sbjct: 626 DMEVGSA----LLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHS 681

Query: 232 HLIANADVQSIAVADQEDSFVV 253
            ++A+ D  +    D   +F++
Sbjct: 682 -MVAHLDAVTCLAVDPNGAFLM 702


>gi|89886477 zinedin isoform 1 [Homo sapiens]
          Length = 753

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 53/262 (20%), Positives = 107/262 (40%), Gaps = 32/262 (12%)

Query: 18  GIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYFQEK----------FFPGHESRATEALC 67
           GIR +A+++  + L  +  DGT++++NL      +K           F  H         
Sbjct: 440 GIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAM 499

Query: 68  WAEGQRLFSAGLNGEIMEYDLQALN-----------IKYAMDAFGGPIWSMAASPSGSQL 116
            +  +  +S G +  I  + +  L+           + + ++  G  +W +A SP+  +L
Sbjct: 500 GSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRL 559

Query: 117 LVGCEDGSVKLFQITPDKIQFERNFDRQKSRILSLSWHPSGT---HIAAG--SIDYISVF 171
                DG+V+++  +         F       +  S   + T   HI A   S D + ++
Sbjct: 560 ASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTV-LY 618

Query: 172 DVKSGSAVHKMIVDRQYMGVSKRKCIVWGVAFLSDGTIISVDSAGKVQFWDSATGTLVKS 231
           D++ GSA    ++  +  G S    I   V+  +    I+      ++F D+ TG  V S
Sbjct: 619 DMEVGSA----LLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHS 674

Query: 232 HLIANADVQSIAVADQEDSFVV 253
            ++A+ D  +    D   +F++
Sbjct: 675 -MVAHLDAVTCLAVDPNGAFLM 695


>gi|157384986 transducin-like enhancer protein 3 isoform b [Homo
           sapiens]
          Length = 769

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 46/183 (25%), Positives = 82/183 (44%), Gaps = 21/183 (11%)

Query: 36  TDGTVEIYNLSANYFQEKFFPGHESRATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKY 95
           +DG + +++L  N    + F GH   A+      +G +L++ GL+  +  +DL+    + 
Sbjct: 593 SDGNIAVWDLH-NQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLRE-GRQL 650

Query: 96  AMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQIT-PDKIQFERNFDRQKSRILSLSWH 154
               F   I+S+   P+G  L VG E  +V++   T PDK Q   +    +S +LSL + 
Sbjct: 651 QQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLH----ESCVLSLKFA 706

Query: 155 PSGTHIAAGSIDYI----------SVFDVKSGSAVHK--MIVDRQYM--GVSKRKCIVWG 200
             G    +   D +          S+F  K  S+V    +  D +Y+  G   +K  V+ 
Sbjct: 707 YCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYE 766

Query: 201 VAF 203
           V +
Sbjct: 767 VIY 769


>gi|157384984 transducin-like enhancer protein 3 isoform c [Homo
           sapiens]
          Length = 760

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 46/183 (25%), Positives = 82/183 (44%), Gaps = 21/183 (11%)

Query: 36  TDGTVEIYNLSANYFQEKFFPGHESRATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKY 95
           +DG + +++L  N    + F GH   A+      +G +L++ GL+  +  +DL+    + 
Sbjct: 584 SDGNIAVWDLH-NQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLRE-GRQL 641

Query: 96  AMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQIT-PDKIQFERNFDRQKSRILSLSWH 154
               F   I+S+   P+G  L VG E  +V++   T PDK Q   +    +S +LSL + 
Sbjct: 642 QQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLH----ESCVLSLKFA 697

Query: 155 PSGTHIAAGSIDYI----------SVFDVKSGSAVHK--MIVDRQYM--GVSKRKCIVWG 200
             G    +   D +          S+F  K  S+V    +  D +Y+  G   +K  V+ 
Sbjct: 698 YCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYE 757

Query: 201 VAF 203
           V +
Sbjct: 758 VIY 760


>gi|157384982 transducin-like enhancer protein 3 isoform a [Homo
           sapiens]
          Length = 772

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 46/183 (25%), Positives = 82/183 (44%), Gaps = 21/183 (11%)

Query: 36  TDGTVEIYNLSANYFQEKFFPGHESRATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKY 95
           +DG + +++L  N    + F GH   A+      +G +L++ GL+  +  +DL+    + 
Sbjct: 596 SDGNIAVWDLH-NQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLRE-GRQL 653

Query: 96  AMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQIT-PDKIQFERNFDRQKSRILSLSWH 154
               F   I+S+   P+G  L VG E  +V++   T PDK Q   +    +S +LSL + 
Sbjct: 654 QQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLH----ESCVLSLKFA 709

Query: 155 PSGTHIAAGSIDYI----------SVFDVKSGSAVHK--MIVDRQYM--GVSKRKCIVWG 200
             G    +   D +          S+F  K  S+V    +  D +Y+  G   +K  V+ 
Sbjct: 710 YCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYE 769

Query: 201 VAF 203
           V +
Sbjct: 770 VIY 772


>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
           sapiens]
          Length = 589

 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 48/236 (20%), Positives = 101/236 (42%), Gaps = 21/236 (8%)

Query: 27  QSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHESRATEALCWAEGQRLFSAGLNGEIMEY 86
           + N +    TD T++++N          + GH S  T        +R+ S   +  +  +
Sbjct: 312 RDNIIISGSTDRTLKVWNAETGECIHTLY-GHTS--TVRCMHLHEKRVVSGSRDATLRVW 368

Query: 87  DLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQITPDKIQFERNFDRQKS 146
           D++     + +   G           G +++ G  D  VK++   P+            +
Sbjct: 369 DIETGQCLHVL--MGHVAAVRCVQYDGRRVVSGAYDFMVKVWD--PETETCLHTLQGHTN 424

Query: 147 RILSLSWHPSGTHIAAGSIDY-ISVFDVKSGSAVHKMIVDRQYMGVSKRKCIVWGVAFLS 205
           R+ SL +   G H+ +GS+D  I V+DV++G+ +H +         +  + +  G+  L 
Sbjct: 425 RVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTL---------TGHQSLTSGME-LK 472

Query: 206 DGTIISVDSAGKVQFWDSATGTLVKSHLIANADVQSIAVADQEDSFVVGTA-EGTV 260
           D  ++S ++   V+ WD  TG  +++    N    ++       +FV+ ++ +GTV
Sbjct: 473 DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 528


>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
           sapiens]
          Length = 707

 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 48/236 (20%), Positives = 101/236 (42%), Gaps = 21/236 (8%)

Query: 27  QSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHESRATEALCWAEGQRLFSAGLNGEIMEY 86
           + N +    TD T++++N          + GH S  T        +R+ S   +  +  +
Sbjct: 430 RDNIIISGSTDRTLKVWNAETGECIHTLY-GHTS--TVRCMHLHEKRVVSGSRDATLRVW 486

Query: 87  DLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQITPDKIQFERNFDRQKS 146
           D++     + +   G           G +++ G  D  VK++   P+            +
Sbjct: 487 DIETGQCLHVL--MGHVAAVRCVQYDGRRVVSGAYDFMVKVWD--PETETCLHTLQGHTN 542

Query: 147 RILSLSWHPSGTHIAAGSIDY-ISVFDVKSGSAVHKMIVDRQYMGVSKRKCIVWGVAFLS 205
           R+ SL +   G H+ +GS+D  I V+DV++G+ +H +         +  + +  G+  L 
Sbjct: 543 RVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTL---------TGHQSLTSGME-LK 590

Query: 206 DGTIISVDSAGKVQFWDSATGTLVKSHLIANADVQSIAVADQEDSFVVGTA-EGTV 260
           D  ++S ++   V+ WD  TG  +++    N    ++       +FV+ ++ +GTV
Sbjct: 591 DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 646


>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
           sapiens]
          Length = 627

 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 48/236 (20%), Positives = 101/236 (42%), Gaps = 21/236 (8%)

Query: 27  QSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHESRATEALCWAEGQRLFSAGLNGEIMEY 86
           + N +    TD T++++N          + GH S  T        +R+ S   +  +  +
Sbjct: 350 RDNIIISGSTDRTLKVWNAETGECIHTLY-GHTS--TVRCMHLHEKRVVSGSRDATLRVW 406

Query: 87  DLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQITPDKIQFERNFDRQKS 146
           D++     + +   G           G +++ G  D  VK++   P+            +
Sbjct: 407 DIETGQCLHVL--MGHVAAVRCVQYDGRRVVSGAYDFMVKVWD--PETETCLHTLQGHTN 462

Query: 147 RILSLSWHPSGTHIAAGSIDY-ISVFDVKSGSAVHKMIVDRQYMGVSKRKCIVWGVAFLS 205
           R+ SL +   G H+ +GS+D  I V+DV++G+ +H +         +  + +  G+  L 
Sbjct: 463 RVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTL---------TGHQSLTSGME-LK 510

Query: 206 DGTIISVDSAGKVQFWDSATGTLVKSHLIANADVQSIAVADQEDSFVVGTA-EGTV 260
           D  ++S ++   V+ WD  TG  +++    N    ++       +FV+ ++ +GTV
Sbjct: 511 DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 566


>gi|51242945 striatin, calmodulin binding protein [Homo sapiens]
          Length = 780

 Score = 42.7 bits (99), Expect = 0.001
 Identities = 61/300 (20%), Positives = 123/300 (41%), Gaps = 33/300 (11%)

Query: 18  GIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYFQEKF----------FPGHESRATEALC 67
           GIR +A++     L  +  D T++++NL      +K           F  H+      + 
Sbjct: 465 GIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVM 524

Query: 68  WAEGQRLFSAGLNGEIMEYDLQALNI----KYAMDAFGGP-------IWSMAASPSGSQL 116
            + G++ +S G +G I  ++    NI     Y      GP       +W +A S +  +L
Sbjct: 525 SSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRL 584

Query: 117 LVGCEDGSVKLF---QITPDKIQFERNFDRQKSRILSLSWHPSGTHIAAGSIDYISVFDV 173
           L    DG+++L+   ++ P    F    +      + L        +A+ S  Y S+F++
Sbjct: 585 LSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNM 644

Query: 174 KSGSAVHKMIVDRQYMGVSKRKCIVWGVAFLSDGTI---ISVDSAGKVQFWDSATGTLVK 230
           ++   +  + ++      +   C +  V  +S  T+   I+      ++F+D+ TG L+ 
Sbjct: 645 ETQQRI--LTLESNVDTTANSSCQINRV--ISHPTLPISITAHEDRHIKFYDNNTGKLIH 700

Query: 231 SHLIANADVQSIAVADQEDSFVVGTAEGTVFHFQLVPVTSNSSEKQWVRTKPFQHHTHDV 290
           S +     V S+AV       + G+ + ++  + L   T    ++     K F+   HDV
Sbjct: 701 SMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKT--CIQEFTAHRKKFEESIHDV 758



 Score = 34.7 bits (78), Expect = 0.30
 Identities = 23/86 (26%), Positives = 42/86 (48%), Gaps = 2/86 (2%)

Query: 86  YDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQITPDKIQFERNFDRQK 145
           YD     + ++M A    + S+A  P+G  L+ G  D S++L+ +       E    R+K
Sbjct: 691 YDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKK 750

Query: 146 --SRILSLSWHPSGTHIAAGSIDYIS 169
               I  +++HPS  +IA+   D ++
Sbjct: 751 FEESIHDVAFHPSKCYIASAGADALA 776


>gi|45594312 TNF receptor-associated factor 7 [Homo sapiens]
          Length = 670

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 56/287 (19%), Positives = 124/287 (43%), Gaps = 24/287 (8%)

Query: 21  CVAYNNQSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHESRATEALCWAEGQRLFSAGLN 80
           C+   +  + L    +D T+++++    Y  +K   GH+     ALC  +G +L+S   +
Sbjct: 401 CLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVL-ALC-IQGCKLYSGSAD 458

Query: 81  GEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQITPDKIQFERN 140
             I+ +D+Q L     + A   P+ ++ +S     +L      ++K++ I   +++ ++ 
Sbjct: 459 CTIIVWDIQNLQKVNTIRAHDNPVCTLVSS---HNVLFSGSLKAIKVWDIVGTELKLKKE 515

Query: 141 FDRQKSRILSLSWHPSGTHIAAGSIDYISVFDVKSGSAVHKMIVDRQYMGVSKRKCIVWG 200
                  + +L    + +++ +GS   I ++D+++   +H +    Q  G S     V+ 
Sbjct: 516 LTGLNHWVRALV--AAQSYLYSGSYQTIKIWDIRTLDCIHVL----QTSGGS-----VYS 564

Query: 201 VAFLSDGTIISVDSAGKVQFWDSATGTLVKSHLIANADVQSIAVADQEDSFVVGTAEGTV 260
           +A +++  I+       +  WD  +   V++       V ++AV    D   V +A    
Sbjct: 565 IA-VTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSAS--- 620

Query: 261 FHFQLVPVTSNSSEKQWVRTKPFQHHTHDVRTVAHSPTALISGGTDT 307
            + + + V S  +    + T+    H   V  +A S   L SG  D+
Sbjct: 621 -YDRSLRVWSMDN---MICTQTLLRHQGSVTALAVSRGRLFSGAVDS 663


>gi|5901892 WD repeat and HMG-box DNA binding protein 1 isoform 1
           [Homo sapiens]
          Length = 1129

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 41/176 (23%), Positives = 82/176 (46%), Gaps = 10/176 (5%)

Query: 22  VAYNNQSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHESRATEALCWAEGQRLFSAGLNG 81
           V +N    ++A   +D  V+I ++  +  Q+K F GH++         +   L SA  +G
Sbjct: 100 VVFNGDGTKIAAGSSDFLVKIVDVMDSS-QQKTFRGHDAPVLSLSFDPKDIFLASASCDG 158

Query: 82  EIMEYDL--QALNIKYAM-----DAFGGP-IWSMAASPSGSQLLVGCEDGSVKLFQITPD 133
            +  + +  Q   I + +     D      I  +A  P   +LL    + SVKL++    
Sbjct: 159 SVRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESW 218

Query: 134 KIQFERNFDRQKSRILSLSWHPSGTHIAAGSID-YISVFDVKSGSAVHKMIVDRQY 188
             QF+ + +     +  ++W P G ++AAGSI+  I V++V++   + ++  ++ Y
Sbjct: 219 SHQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKGY 274


>gi|75677340 WD repeat domain, phosphoinositide interacting 2
           isoform e [Homo sapiens]
          Length = 384

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 27/96 (28%), Positives = 48/96 (50%), Gaps = 3/96 (3%)

Query: 423 DNISLKRVSKMPAFLRSALQILFSEDSTKLFVASNQGA-LHIVQLSGGSFKHLHAFQPQS 481
           D I+L+  + +PA       + F    TKL  AS +G  + +  +  G  + L  F+   
Sbjct: 129 DTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEG--QKLFEFRRGV 186

Query: 482 GTVEAMCLLAVSPDGNWLAASGTSAGVHVYNVKQLK 517
               ++C LA S DG +L+AS  +  VH++ ++ +K
Sbjct: 187 KRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVK 222



 Score = 37.0 bits (84), Expect = 0.061
 Identities = 39/147 (26%), Positives = 63/147 (42%), Gaps = 13/147 (8%)

Query: 425 ISLKRVSKMPA--FLRSALQILFSEDSTKLFVASNQGALHIVQLSGGSFKH-------LH 475
           +SLK   K+    F +      +S  +T L V  N+  L IV L    + H       LH
Sbjct: 32  VSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRL-IVCLEESLYIHNIRDMKVLH 90

Query: 476 AFQPQSGTVEAMCLLAVSPDGNWLA--ASGTSAGVHVYNVKQLKLHCTVPAYNFPVTAMA 533
             +        +C L+++ D  +LA   S T   V V++   L+    +PA++ P+ A+A
Sbjct: 91  TIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALA 150

Query: 534 IAPNTNNLVIAHSDQQVFE-YSIPDKQ 559
              +   L  A     V   +SIP+ Q
Sbjct: 151 FDASGTKLATASEKGTVIRVFSIPEGQ 177



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 24/86 (27%), Positives = 42/86 (48%), Gaps = 2/86 (2%)

Query: 81  GEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSV-KLFQITPDKIQFE- 138
           GE+  +D   L     + A   P+ ++A   SG++L    E G+V ++F I   +  FE 
Sbjct: 123 GEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEF 182

Query: 139 RNFDRQKSRILSLSWHPSGTHIAAGS 164
           R   ++   I SL++   G  ++A S
Sbjct: 183 RRGVKRCVSICSLAFSMDGMFLSASS 208


>gi|75677331 WD repeat domain, phosphoinositide interacting 2
           isoform d [Homo sapiens]
          Length = 425

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 27/96 (28%), Positives = 48/96 (50%), Gaps = 3/96 (3%)

Query: 423 DNISLKRVSKMPAFLRSALQILFSEDSTKLFVASNQGA-LHIVQLSGGSFKHLHAFQPQS 481
           D I+L+  + +PA       + F    TKL  AS +G  + +  +  G  + L  F+   
Sbjct: 170 DTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEG--QKLFEFRRGV 227

Query: 482 GTVEAMCLLAVSPDGNWLAASGTSAGVHVYNVKQLK 517
               ++C LA S DG +L+AS  +  VH++ ++ +K
Sbjct: 228 KRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVK 263



 Score = 37.0 bits (84), Expect = 0.061
 Identities = 39/147 (26%), Positives = 63/147 (42%), Gaps = 13/147 (8%)

Query: 425 ISLKRVSKMPA--FLRSALQILFSEDSTKLFVASNQGALHIVQLSGGSFKH-------LH 475
           +SLK   K+    F +      +S  +T L V  N+  L IV L    + H       LH
Sbjct: 73  VSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRL-IVCLEESLYIHNIRDMKVLH 131

Query: 476 AFQPQSGTVEAMCLLAVSPDGNWLA--ASGTSAGVHVYNVKQLKLHCTVPAYNFPVTAMA 533
             +        +C L+++ D  +LA   S T   V V++   L+    +PA++ P+ A+A
Sbjct: 132 TIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALA 191

Query: 534 IAPNTNNLVIAHSDQQVFE-YSIPDKQ 559
              +   L  A     V   +SIP+ Q
Sbjct: 192 FDASGTKLATASEKGTVIRVFSIPEGQ 218



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 24/86 (27%), Positives = 42/86 (48%), Gaps = 2/86 (2%)

Query: 81  GEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSV-KLFQITPDKIQFE- 138
           GE+  +D   L     + A   P+ ++A   SG++L    E G+V ++F I   +  FE 
Sbjct: 164 GEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEF 223

Query: 139 RNFDRQKSRILSLSWHPSGTHIAAGS 164
           R   ++   I SL++   G  ++A S
Sbjct: 224 RRGVKRCVSICSLAFSMDGMFLSASS 249


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.135    0.414 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,629,656
Number of Sequences: 37866
Number of extensions: 1165722
Number of successful extensions: 2839
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 51
Number of HSP's successfully gapped in prelim test: 119
Number of HSP's that attempted gapping in prelim test: 2384
Number of HSP's gapped (non-prelim): 546
length of query: 686
length of database: 18,247,518
effective HSP length: 109
effective length of query: 577
effective length of database: 14,120,124
effective search space: 8147311548
effective search space used: 8147311548
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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