Search of human proteins with 186928839

Search of human proteins with 186928839

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|186928839 retinol dehydrogenase 12 [Homo sapiens]
         (316 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|186928839 retinol dehydrogenase 12 [Homo sapiens]                  631   0.0  
gi|166795268 retinol dehydrogenase 11 [Homo sapiens]                  459   e-129
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]        286   1e-77
gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo...   270   9e-73
gi|146231950 dehydrogenase/reductase (SDR family) member 13 [Hom...   242   3e-64
gi|19923931 retinol dehydrogenase 13 isoform 2 [Homo sapiens]         225   3e-59
gi|7706523 WW domain-containing oxidoreductase isoform 1 [Homo s...   212   4e-55
gi|193804850 dehydrogenase/reductase (SDR family) X-linked [Homo...   199   2e-51
gi|13375997 dehydrogenase/reductase (SDR family) member 12 isofo...    82   6e-16
gi|150247226 retinol dehydrogenase 16 [Homo sapiens]                   78   9e-15
gi|72534732 dehydrogenase/reductase (SDR family) member 12 isofo...    77   3e-14
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]         74   1e-13
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A...    72   6e-13
gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]    70   2e-12
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s...    69   5e-12
gi|22507405 short chain dehydrogenase/reductase family 9C, membe...    68   1e-11
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap...    66   5e-11
gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo...    65   1e-10
gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Hom...    65   1e-10
gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Hom...    65   1e-10
gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo...    65   1e-10
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo...    64   2e-10
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa...    62   5e-10
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ...    62   9e-10
gi|4502601 carbonyl reductase 3 [Homo sapiens]                         62   9e-10
gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B...    60   3e-09
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo...    60   3e-09
gi|7705421 hydroxysteroid (17-beta) dehydrogenase 7 [Homo sapiens]     59   4e-09
gi|4502599 carbonyl reductase 1 [Homo sapiens]                         56   4e-08
gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]     56   5e-08

>gi|186928839 retinol dehydrogenase 12 [Homo sapiens]
          Length = 316

 Score =  631 bits (1628), Expect = 0.0
 Identities = 316/316 (100%), Positives = 316/316 (100%)

Query: 1   MLVTLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETARELA 60
           MLVTLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETARELA
Sbjct: 1   MLVTLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETARELA 60

Query: 61  SRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLH 120
           SRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLH
Sbjct: 61  SRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLH 120

Query: 121 ILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLLLERLKVSAPARVVNVSSVAHHI 180
           ILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLLLERLKVSAPARVVNVSSVAHHI
Sbjct: 121 ILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLLLERLKVSAPARVVNVSSVAHHI 180

Query: 181 GKIPFHDLQSEKRYSRGFAYCHSKLANVLFTRELAKRLQGTGVTTYAVHPGVVRSELVRH 240
           GKIPFHDLQSEKRYSRGFAYCHSKLANVLFTRELAKRLQGTGVTTYAVHPGVVRSELVRH
Sbjct: 181 GKIPFHDLQSEKRYSRGFAYCHSKLANVLFTRELAKRLQGTGVTTYAVHPGVVRSELVRH 240

Query: 241 SSLLCLLWRLFSPFVKTAREGAQTSLHCALAEGLEPLSGKYFSDCKRTWVSPRARNNKTA 300
           SSLLCLLWRLFSPFVKTAREGAQTSLHCALAEGLEPLSGKYFSDCKRTWVSPRARNNKTA
Sbjct: 241 SSLLCLLWRLFSPFVKTAREGAQTSLHCALAEGLEPLSGKYFSDCKRTWVSPRARNNKTA 300

Query: 301 ERLWNVSCELLGIRWE 316
           ERLWNVSCELLGIRWE
Sbjct: 301 ERLWNVSCELLGIRWE 316


>gi|166795268 retinol dehydrogenase 11 [Homo sapiens]
          Length = 318

 Score =  459 bits (1181), Expect = e-129
 Identities = 227/313 (72%), Positives = 262/313 (83%), Gaps = 2/313 (0%)

Query: 1   MLVTLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETARELA 60
           M   L LL  F   LYM AP IRK  + GVC + VQLPGKVVV+TGANTGIGKETA+ELA
Sbjct: 5   MFPLLLLLLPFL--LYMAAPQIRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKELA 62

Query: 61  SRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLH 120
            RGARVY+ACRDV KGE  A EI+  T N QVLVRKLDLSDTKSIRAFA+GFLAEEK LH
Sbjct: 63  QRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLH 122

Query: 121 ILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLLLERLKVSAPARVVNVSSVAHHI 180
           +LINNAGVMMCPYSKTADGFE H+GVNHLGHFLLT+LLLE+LK SAP+R+VNVSS+AHH+
Sbjct: 123 VLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSSLAHHL 182

Query: 181 GKIPFHDLQSEKRYSRGFAYCHSKLANVLFTRELAKRLQGTGVTTYAVHPGVVRSELVRH 240
           G+I FH+LQ EK Y+ G AYCHSKLAN+LFT+ELA+RL+G+GVTTY+VHPG V+SELVRH
Sbjct: 183 GRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELARRLKGSGVTTYSVHPGTVQSELVRH 242

Query: 241 SSLLCLLWRLFSPFVKTAREGAQTSLHCALAEGLEPLSGKYFSDCKRTWVSPRARNNKTA 300
           SS +  +W LFS F+KT ++GAQTSLHCAL EGLE LSG +FSDC   WVS +ARN   A
Sbjct: 243 SSFMRWMWWLFSFFIKTPQQGAQTSLHCALTEGLEILSGNHFSDCHVAWVSAQARNETIA 302

Query: 301 ERLWNVSCELLGI 313
            RLW+VSC+LLG+
Sbjct: 303 RRLWDVSCDLLGL 315


>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
          Length = 331

 Score =  286 bits (733), Expect = 1e-77
 Identities = 151/299 (50%), Positives = 200/299 (66%), Gaps = 7/299 (2%)

Query: 22  IRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAAS 81
           ++ +  GG C +   +PGK V++TGANTGIGK+TA ELA RG  + +ACRD+ K E+AA 
Sbjct: 21  LKDYVTGGACPSKATIPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAK 80

Query: 82  EIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFE 141
           +IR +T N  V  R LDL+  KSIR FA   + EE+++ ILINNAGVM CP+  T DGFE
Sbjct: 81  DIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTTEDGFE 140

Query: 142 THLGVNHLGHFLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQ-SEKRYSRGFAY 200
              GVNHLGHFLLT LLL++LK SAP+R++N+SS+AH  G I F DL    ++Y+   AY
Sbjct: 141 MQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAY 200

Query: 201 CHSKLANVLFTRELAKRLQGTGVTTYAVHPGVVRSELVRHSSL------LCLLWRLFSPF 254
           C SKLA VLFT+EL++RLQG+GVT  A+HPGV R+EL RH+ +         L  +F   
Sbjct: 201 CQSKLAIVLFTKELSRRLQGSGVTVNALHPGVARTELGRHTGIHGSTFSSTTLGPIFWLL 260

Query: 255 VKTAREGAQTSLHCALAEGLEPLSGKYFSDCKRTWVSPRARNNKTAERLWNVSCELLGI 313
           VK+    AQ S + A+AE L  +SGKYF   K+   +P A + + A RLW  S  L+G+
Sbjct: 261 VKSPELAAQPSTYLAVAEELADVSGKYFDGLKQKAPAPEAEDEEVARRLWAESARLVGL 319


>gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo
           sapiens]
          Length = 336

 Score =  270 bits (691), Expect = 9e-73
 Identities = 145/313 (46%), Positives = 201/313 (64%), Gaps = 20/313 (6%)

Query: 18  VAPSIRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGE 77
           V P +++   GG       + GK V+ITGAN+G+G+ TA EL   GARV + CRD  + E
Sbjct: 25  VGPRVQRLRRGG---DPGLMHGKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAE 81

Query: 78  SAASEIRVDTKNS-------------QVLVRKLDLSDTKSIRAFAEGFLAEEKQLHILIN 124
            AA ++R + + +             +++VR+LDL+  +S+RAF +  L EE +L +LIN
Sbjct: 82  EAAGQLRRELRQAAECGPEPGVSGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLIN 141

Query: 125 NAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLLLERLKVSAPARVVNVSSVAHHIGKIP 184
           NAG+  CPY KT DGFE   GVNHLGHFLLT LLL  LK SAP+R+V VSS  +  G I 
Sbjct: 142 NAGIFQCPYMKTEDGFEMQFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDIN 201

Query: 185 FHDLQSEKRYSRGFAYCHSKLANVLFTRELAKRLQGTGVTTYAVHPGVVRSELVRHSSLL 244
           F DL SE+ Y++ F Y  SKLAN+LFTRELA+RL+GT VT   +HPG+VR+ L RH  + 
Sbjct: 202 FDDLNSEQSYNKSFCYSRSKLANILFTRELARRLEGTNVTVNVLHPGIVRTNLGRHIHIP 261

Query: 245 CLLWRLFS----PFVKTAREGAQTSLHCALAEGLEPLSGKYFSDCKRTWVSPRARNNKTA 300
            L+  LF+     F KT  EGAQTS++ A +  +E +SG+YF DCK   + P+A +   A
Sbjct: 262 LLVKPLFNLVSWAFFKTPVEGAQTSIYLASSPEVEGVSGRYFGDCKEEELLPKAMDESVA 321

Query: 301 ERLWNVSCELLGI 313
            +LW++S  ++G+
Sbjct: 322 RKLWDISEVMVGL 334


>gi|146231950 dehydrogenase/reductase (SDR family) member 13 [Homo
           sapiens]
          Length = 377

 Score =  242 bits (618), Expect = 3e-64
 Identities = 143/287 (49%), Positives = 186/287 (64%), Gaps = 17/287 (5%)

Query: 37  LPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRK 96
           L G+  V+TGAN+GIGK TA ELA RGARV +ACR   +GE+AA ++R ++ N++V+   
Sbjct: 34  LRGRTAVVTGANSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESGNNEVIFMA 93

Query: 97  LDLSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTY 156
           LDL+   S+RAFA  FL+ E +L ILI+NAG+  C   +T + F   L VNH+G FLLT+
Sbjct: 94  LDLASLASVRAFATAFLSSEPRLDILIHNAGISSC--GRTREAFNLLLRVNHIGPFLLTH 151

Query: 157 LLLERLKVSAPARVVNVSSVAHHIGKIPFHDL-------QSEKRYSRGFAYCHSKLANVL 209
           LLL  LK  AP+RVV V+S AH  G++ F  L       + E R     AY  +KLANVL
Sbjct: 152 LLLPCLKACAPSRVVVVASAAHCRGRLDFKRLDRPVVGWRQELR-----AYADTKLANVL 206

Query: 210 FTRELAKRLQGTGVTTYAVHPGVVRSEL-VRH--SSLLCLLWRLFSPFVKTAREGAQTSL 266
           F RELA +L+ TGVT YA HPG V SEL +RH    L  LL  L    ++  R GAQT L
Sbjct: 207 FARELANQLEATGVTCYAAHPGPVNSELFLRHVPGWLRPLLRPLAWLVLRAPRGGAQTPL 266

Query: 267 HCALAEGLEPLSGKYFSDCKRTWVSPRARNNKTAERLWNVSCELLGI 313
           +CAL EG+EPLSG+YF++C    V P AR+++ A RLW  S  L G+
Sbjct: 267 YCALQEGIEPLSGRYFANCHVEEVPPAARDDRAAHRLWEASKRLAGL 313


>gi|19923931 retinol dehydrogenase 13 isoform 2 [Homo sapiens]
          Length = 260

 Score =  225 bits (574), Expect = 3e-59
 Identities = 124/246 (50%), Positives = 162/246 (65%), Gaps = 7/246 (2%)

Query: 75  KGESAASEIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYS 134
           K E+AA +IR +T N  V  R LDL+  KSIR FA   + EE+++ ILINNAGVM CP+ 
Sbjct: 3   KCEAAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHW 62

Query: 135 KTADGFETHLGVNHLGHFLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQ-SEKR 193
            T DGFE   GVNHLGHFLLT LLL++LK SAP+R++N+SS+AH  G I F DL    ++
Sbjct: 63  TTEDGFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRK 122

Query: 194 YSRGFAYCHSKLANVLFTRELAKRLQGTGVTTYAVHPGVVRSELVRHSSL------LCLL 247
           Y+   AYC SKLA VLFT+EL++RLQG+GVT  A+HPGV R+EL RH+ +         L
Sbjct: 123 YNTKAAYCQSKLAIVLFTKELSRRLQGSGVTVNALHPGVARTELGRHTGIHGSTFSSTTL 182

Query: 248 WRLFSPFVKTAREGAQTSLHCALAEGLEPLSGKYFSDCKRTWVSPRARNNKTAERLWNVS 307
             +F   VK+    AQ S + A+AE L  +SGKYF   K+   +P A + + A RLW  S
Sbjct: 183 GPIFWLLVKSPELAAQPSTYLAVAEELADVSGKYFDGLKQKAPAPEAEDEEVARRLWAES 242

Query: 308 CELLGI 313
             L+G+
Sbjct: 243 ARLVGL 248


>gi|7706523 WW domain-containing oxidoreductase isoform 1 [Homo
           sapiens]
          Length = 414

 Score =  212 bits (539), Expect = 4e-55
 Identities = 127/305 (41%), Positives = 176/305 (57%), Gaps = 13/305 (4%)

Query: 20  PSIRKFFAGGVCRTNV----QLPGKVVVITGANTGIGKETARELASRGARVYIACRDVLK 75
           P+ R+ + G      +       GKVVV+TGAN+GIG ETA+  A  GA V +ACR++ +
Sbjct: 101 PTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMAR 160

Query: 76  GESAASEIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSK 135
              A S I  +   ++V    LDL+  +S++ FAE F A+   LH+L+ NA     P+S 
Sbjct: 161 ASEAVSRILEEWHKAKVEAMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSL 220

Query: 136 TADGFETHLGVNHLGHFLLTYLLLERLKVSAPARVVNVSSVAHH-------IGKIPFHDL 188
           T DG ET   VNHLGHF L  LL + L  SAPARV+ VSS +H        +GK+ F  L
Sbjct: 221 TKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDINDSLGKLDFSRL 280

Query: 189 QSEKR-YSRGFAYCHSKLANVLFTRELAKRLQGTGVTTYAVHPG-VVRSELVRHSSLLCL 246
              K  Y    AY  SKL N+LF+ EL +RL   GVT+ AVHPG ++ S + R   +  L
Sbjct: 281 SPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHRSWWVYTL 340

Query: 247 LWRLFSPFVKTAREGAQTSLHCALAEGLEPLSGKYFSDCKRTWVSPRARNNKTAERLWNV 306
           L+ L  PF K+ ++GA T+++CA    LE L G YF++C R   SP A++ +TA  LW +
Sbjct: 341 LFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPEAQSEETARTLWAL 400

Query: 307 SCELL 311
           S  L+
Sbjct: 401 SERLI 405


>gi|193804850 dehydrogenase/reductase (SDR family) X-linked [Homo
           sapiens]
          Length = 330

 Score =  199 bits (507), Expect = 2e-51
 Identities = 123/288 (42%), Positives = 163/288 (56%), Gaps = 16/288 (5%)

Query: 38  PGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKL 97
           P +V ++TG   GIG  TA+ LA  G  V IA  +  K +   S+I+ +T N +V     
Sbjct: 42  PDRVAIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYC 101

Query: 98  DLSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYL 157
           DL+   SIR F + F  ++  LH+LINNAGVMM P  KT DGFE H G+N+LGHFLLT L
Sbjct: 102 DLASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQRKTRDGFEEHFGLNYLGHFLLTNL 161

Query: 158 LLERLKVSA----PARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFTRE 213
           LL+ LK S      ARVV VSS  H++ ++   DLQS   YS   AY  SKLA VLFT  
Sbjct: 162 LLDTLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVLFTYH 221

Query: 214 LAKRL--QGTGVTTYAVHPGVVRSELVRH------SSLLCLLWRLFSPFVKTAREGAQTS 265
           L + L  +G+ VT   V PGVV +++ +H       +   L W LF    KT  EGA TS
Sbjct: 222 LQRLLAAEGSHVTANVVDPGVVNTDVYKHVFWATRLAKKLLGWLLF----KTPDEGAWTS 277

Query: 266 LHCALAEGLEPLSGKYFSDCKRTWVSPRARNNKTAERLWNVSCELLGI 313
           ++ A+   LE + G Y  + K T       N K  ++LW+ SCE+ G+
Sbjct: 278 IYAAVTPELEGVGGHYLYNEKETKSLHVTYNQKLQQQLWSKSCEMTGV 325


>gi|13375997 dehydrogenase/reductase (SDR family) member 12 isoform
           2 [Homo sapiens]
          Length = 242

 Score = 82.0 bits (201), Expect = 6e-16
 Identities = 67/207 (32%), Positives = 103/207 (49%), Gaps = 11/207 (5%)

Query: 80  ASEIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADG 139
           A ++ + + +  + +  +DLSD K I  F E F  E K LH+LINNAG M+     T DG
Sbjct: 32  AKQLPLKSPSENIFLHIVDLSDPKQIWKFVENFKQEHK-LHVLINNAGCMVNKRELTEDG 90

Query: 140 FETHLGVNHLGHFLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKR-YSRGF 198
            E +   N LG ++LT  L+  L+     RV+ VSS    + K+  +DLQSE+  +    
Sbjct: 91  LEKNFAANTLGVYILTTGLIPVLEKEHDPRVITVSSGGMLVQKLNTNDLQSERTPFDGTM 150

Query: 199 AYCHSKLANVLFTRELAKRLQG-TGVTTYAVHPGVVRSELVRHSSLLCLLWRLFSPFVKT 257
            Y  +K   V+ T   A   QG   +   ++HPG   +  VR +  +      F   +++
Sbjct: 151 VYAQNKRQQVVLTERWA---QGHPAIHFSSMHPGWADTPGVRQA--MPGFHARFGDRLRS 205

Query: 258 AREGAQTSLHCAL--AEGLEPLSGKYF 282
             +GA T L  AL  A   +P SG++F
Sbjct: 206 EAQGADTMLWLALSSAAAAQP-SGRFF 231


>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
          Length = 317

 Score = 78.2 bits (191), Expect = 9e-15
 Identities = 76/230 (33%), Positives = 105/230 (45%), Gaps = 27/230 (11%)

Query: 37  LPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRK 96
           L  K V ITG ++G GK  AR+L +RG RV  AC      E  A ++R  T +    V  
Sbjct: 27  LRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLT----EKGAEQLRGQTSDRLETV-T 81

Query: 97  LDLSDTKSIRAFAEGF--LAEEKQLHILINNAGVMMCPYSK---TADGFETHLGVNHLGH 151
           LD++ T+S+ A A+       +K L  L+NNAG+ +        T   F T L VN LG 
Sbjct: 82  LDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGV 141

Query: 152 FLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFT 211
             +T  LL  ++  A  RVVNVSSV   +G++             G  YC SK     F+
Sbjct: 142 IDVTLSLLPLVR-RARGRVVNVSSV---MGRVSLF----------GGGYCISKYGVEAFS 187

Query: 212 RELAKRLQGTGVTTYAVHPGVVRSELVRHSSLL---CLLWRLFSPFVKTA 258
             L + L   GV    + PG  ++ +      L     +W   SP VK A
Sbjct: 188 DSLRRELSYFGVKVAMIEPGYFKTAVTSKERFLKSFLEIWDRSSPEVKEA 237


>gi|72534732 dehydrogenase/reductase (SDR family) member 12 isoform
           1 [Homo sapiens]
          Length = 271

 Score = 76.6 bits (187), Expect = 3e-14
 Identities = 53/154 (34%), Positives = 79/154 (51%), Gaps = 6/154 (3%)

Query: 80  ASEIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADG 139
           A ++ + + +  + +  +DLSD K I  F E F  E K LH+LINNAG M+     T DG
Sbjct: 32  AKQLPLKSPSENIFLHIVDLSDPKQIWKFVENFKQEHK-LHVLINNAGCMVNKRELTEDG 90

Query: 140 FETHLGVNHLGHFLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKR-YSRGF 198
            E +   N LG ++LT  L+  L+     RV+ VSS    + K+  +DLQSE+  +    
Sbjct: 91  LEKNFAANTLGVYILTTGLIPVLEKEHDPRVITVSSGGMLVQKLNTNDLQSERTPFDGTM 150

Query: 199 AYCHSKLANVLFTRELAKRLQG-TGVTTYAVHPG 231
            Y  +K   V+ T   A   QG   +   ++HPG
Sbjct: 151 VYAQNKRQQVVLTERWA---QGHPAIHFSSMHPG 181


>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
          Length = 300

 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 73/248 (29%), Positives = 114/248 (45%), Gaps = 32/248 (12%)

Query: 1   MLVTLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETARELA 60
           +L+ L ++ S  SF+ +  P  RK            + G++V+ITGA  GIG+ TA E A
Sbjct: 9   LLLPLLIVCSLESFVKLFIPKRRK-----------SVTGEIVLITGAGHGIGRLTAYEFA 57

Query: 61  SRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLH 120
              +++ +   D+ K     +  +     ++V    +D S+ + I + A+   AE   + 
Sbjct: 58  KLKSKLVL--WDINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVS 115

Query: 121 ILINNAGVMMCP--YSKTADGFETHLGVNHLGHFLLTYLLLERLKVSAPARVVNVSSVAH 178
           IL+NNAGV+     ++      E    VN L HF  T   L  +  +    +V V+S A 
Sbjct: 116 ILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAG 175

Query: 179 HIGKIPFHDLQSEKRYSRGFAYCHSKLANVLF----TRELAKRLQGTGVTTYAVHPGVVR 234
           H+  +PF             AYC SK A V F    T ELA  LQ TGV T  + P  V 
Sbjct: 176 HV-SVPFL-----------LAYCSSKFAAVGFHKTLTDELA-ALQITGVKTTCLCPNFVN 222

Query: 235 SELVRHSS 242
           +  +++ S
Sbjct: 223 TGFIKNPS 230


>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
           [Homo sapiens]
          Length = 300

 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 73/247 (29%), Positives = 108/247 (43%), Gaps = 22/247 (8%)

Query: 1   MLVTLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETARELA 60
           M + L +L    + +Y    S+ KFF   + +    + G++V+ITGA  GIG++T  E A
Sbjct: 1   MNIILEILLLLITIIYSYLESLVKFF---IPQRRKSVAGEIVLITGAGHGIGRQTTYEFA 57

Query: 61  SRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLH 120
            R + + +   +    E  A+E R     +   V  +D S+ + I         E   + 
Sbjct: 58  KRQSILVLWDINKRGVEETAAECRKLGVTAHAYV--VDCSNREEIYRSLNQVKKEVGDVT 115

Query: 121 ILINNAG-VMMCPYSKTADGFETH-LGVNHLGHFLLTYLLLERLKVSAPARVVNVSSVAH 178
           I++NNAG V       T D   T    VN LGHF +T  LL  +       +V V+SV  
Sbjct: 116 IVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCG 175

Query: 179 HIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFTRELAKRLQG---TGVTTYAVHPGVVRS 235
           H G IP+              YC SK A V F R L   LQ    TG+ T  + P  V +
Sbjct: 176 HEG-IPYL-----------IPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNT 223

Query: 236 ELVRHSS 242
              ++ S
Sbjct: 224 GFTKNPS 230


>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
          Length = 317

 Score = 70.1 bits (170), Expect = 2e-12
 Identities = 84/275 (30%), Positives = 128/275 (46%), Gaps = 37/275 (13%)

Query: 37  LPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRK 96
           L  K V ITG ++G G   AR+L +RG RV  AC      E  A ++R  T +    V  
Sbjct: 27  LQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLT----EKGAEQLRGQTSDRLETV-T 81

Query: 97  LDLSDTKSIRAFAEGFLAE---EKQLHILINNAGVM----MCPYSKTADGFETHLGVNHL 149
           LD++  +SI A A  ++ E   ++ L  L+NNAG++    +C +  T D     L VN +
Sbjct: 82  LDVTKMESIAA-ATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNM-LKVNLI 139

Query: 150 GHFLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVL 209
           G   +T  +L  ++  A  R+VNVSS+   +G++ F        +  G  YC SK     
Sbjct: 140 GVIQVTLSMLPLVR-RARGRIVNVSSI---LGRVAF--------FVGG--YCVSKYGVEA 185

Query: 210 FTRELAKRLQGTGVTTYAVHPGVVRSELVRHSSLLCLLWRLFSPFVKTARE--GAQ--TS 265
           F+  L + +Q  GV    V PG  R+ +   +  L  + + +    K  +E  G Q   +
Sbjct: 186 FSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDA 245

Query: 266 LHCALAEGLEPLSG--KYFSDCKR---TWVSPRAR 295
           L+  + EGL   S      +DC     T V PR R
Sbjct: 246 LYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTR 280


>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
           sapiens]
          Length = 339

 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 70/266 (26%), Positives = 112/266 (42%), Gaps = 27/266 (10%)

Query: 32  RTNVQLPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEI--RVDTKN 89
           R   +L   VV +TGA++GIG+E A +L+  G  + ++ R V + E          + K 
Sbjct: 43  RPEWELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKE 102

Query: 90  SQVLVRKLDLSDTKSIRAFAEGFLAEEKQLHILINNAGV---MMCPYSKTADGFETHLGV 146
             +LV  LDL+DT S  A  +  L E  ++ IL+NN G+    +C    + D +   + +
Sbjct: 103 KDILVLPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLC-MDTSLDVYRKLIEL 161

Query: 147 NHLGHFLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLA 206
           N+LG   LT  +L  +      ++V V+S+   I  +P               YC SK A
Sbjct: 162 NYLGTVSLTKCVLPHMIERKQGKIVTVNSILGII-SVPL-----------SIGYCASKHA 209

Query: 207 NVLFTRELAKRLQG-TGVTTYAVHPGVVRSELVRHSSLLCLLWRLFSPFVKTAREGAQTS 265
              F   L   L    G+    + PG V+S +V +S        L     KT       S
Sbjct: 210 LRGFFNGLRTELATYPGIIVSNICPGPVQSNIVENS--------LAGEVTKTIGNNGDQS 261

Query: 266 LHCALAEGLEPLSGKYFSDCKRTWVS 291
                +  +  +     +D K  W+S
Sbjct: 262 HKMTTSRCVRLMLISMANDLKEVWIS 287


>gi|22507405 short chain dehydrogenase/reductase family 9C, member 7
           [Homo sapiens]
          Length = 313

 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 65/235 (27%), Positives = 107/235 (45%), Gaps = 24/235 (10%)

Query: 31  CRTNVQLPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNS 90
           C     L  K V ITG ++G G   A++L  RG +V  AC      E  + +++ DT + 
Sbjct: 17  CNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFT----EEGSQKLQRDT-SY 71

Query: 91  QVLVRKLDLSDTKSIRAFAEGFLAE--EKQLHILINNAGVMMCPYSK---TADGFETHLG 145
           ++    LD++ ++SI+A A+    +  E+ L  L+NNAGV +        T D F   + 
Sbjct: 72  RLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVIN 131

Query: 146 VNHLGHFLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKL 205
           VN +G   +T  +L  +K  A  RVVN+SS    +  I             G  YC SK 
Sbjct: 132 VNLVGLIEVTLHMLPMVK-RARGRVVNMSSSGGRVAVI-------------GGGYCVSKF 177

Query: 206 ANVLFTRELAKRLQGTGVTTYAVHPGVVRSELVRHSSLLCLLWRLFSPFVKTARE 260
               F+  + + L   GV    + PG  R+ ++   +L   + +L+    +  R+
Sbjct: 178 GVEAFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRD 232


>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
           sapiens]
          Length = 318

 Score = 65.9 bits (159), Expect = 5e-11
 Identities = 68/240 (28%), Positives = 108/240 (45%), Gaps = 29/240 (12%)

Query: 32  RTNVQLPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQ 91
           R ++      V ITG ++G G+  A +L  RG RV  +C       S A +++    +S+
Sbjct: 21  RQSLPASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCLT----PSGAEDLQ-RVASSR 75

Query: 92  VLVRKLDLSDTKSIRAFAE--GFLAEEKQLHILINNAGVM----MCPYSKTADGFETHLG 145
           +    LD++D +S++  A+      +E  L  L+NNAGV       P+  T D F+  L 
Sbjct: 76  LHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPW-LTRDDFQRVLN 134

Query: 146 VNHLGHFLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKL 205
           VN +G   +T  LL  L+  A  RV+N++SV   +G++           + G  YC SK 
Sbjct: 135 VNTMGPIGVTLALLPLLQ-QARGRVINITSV---LGRLA----------ANGGGYCVSKF 180

Query: 206 ANVLFTRELAKRLQGTGVTTYAVHPGVVRSELVRHSSL---LCLLWRLFSPFVKTAREGA 262
               F+  L + +   G+    V PG  R+ +    SL   L   W    P  +    GA
Sbjct: 181 GLEAFSDSLRRDVAHFGIRVSIVEPGFFRTPVTNLESLEKTLQACWARLPPATQAHYGGA 240


>gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 62/225 (27%), Positives = 103/225 (45%), Gaps = 27/225 (12%)

Query: 40  KVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDL 99
           K + ITG ++G G   AR    +G  V  AC      ES ++ ++ +T + ++    LD+
Sbjct: 30  KYIFITGCDSGFGNLAARTFDKKGFHVIAACLT----ESGSTALKAET-SERLRTVLLDV 84

Query: 100 SDTKSIRAFAEGFLAE--EKQLHILINNAGV--MMCPYS-KTADGFETHLGVNHLGHFLL 154
           +D ++++  A+    +  EK L  LINNAGV  ++ P    T + +   + VN  G   +
Sbjct: 85  TDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISV 144

Query: 155 TYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFTREL 214
           T  +L  +K  A  RV+NVSSV   +  +             G  Y  SK A   F   L
Sbjct: 145 TLNMLPLVK-KAQGRVINVSSVGGRLAIV-------------GGGYTPSKYAVEGFNDSL 190

Query: 215 AKRLQGTGVTTYAVHPGVVRSEL---VRHSSLLCLLWRLFSPFVK 256
            + ++  GV    + PG+ ++ L   V+       +W   SP +K
Sbjct: 191 RRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIK 235


>gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 62/225 (27%), Positives = 103/225 (45%), Gaps = 27/225 (12%)

Query: 40  KVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDL 99
           K + ITG ++G G   AR    +G  V  AC      ES ++ ++ +T + ++    LD+
Sbjct: 30  KYIFITGCDSGFGNLAARTFDKKGFHVIAACLT----ESGSTALKAET-SERLRTVLLDV 84

Query: 100 SDTKSIRAFAEGFLAE--EKQLHILINNAGV--MMCPYS-KTADGFETHLGVNHLGHFLL 154
           +D ++++  A+    +  EK L  LINNAGV  ++ P    T + +   + VN  G   +
Sbjct: 85  TDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISV 144

Query: 155 TYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFTREL 214
           T  +L  +K  A  RV+NVSSV   +  +             G  Y  SK A   F   L
Sbjct: 145 TLNMLPLVK-KAQGRVINVSSVGGRLAIV-------------GGGYTPSKYAVEGFNDSL 190

Query: 215 AKRLQGTGVTTYAVHPGVVRSEL---VRHSSLLCLLWRLFSPFVK 256
            + ++  GV    + PG+ ++ L   V+       +W   SP +K
Sbjct: 191 RRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIK 235


>gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 62/225 (27%), Positives = 103/225 (45%), Gaps = 27/225 (12%)

Query: 40  KVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDL 99
           K + ITG ++G G   AR    +G  V  AC      ES ++ ++ +T + ++    LD+
Sbjct: 30  KYIFITGCDSGFGNLAARTFDKKGFHVIAACLT----ESGSTALKAET-SERLRTVLLDV 84

Query: 100 SDTKSIRAFAEGFLAE--EKQLHILINNAGV--MMCPYS-KTADGFETHLGVNHLGHFLL 154
           +D ++++  A+    +  EK L  LINNAGV  ++ P    T + +   + VN  G   +
Sbjct: 85  TDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISV 144

Query: 155 TYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFTREL 214
           T  +L  +K  A  RV+NVSSV   +  +             G  Y  SK A   F   L
Sbjct: 145 TLNMLPLVK-KAQGRVINVSSVGGRLAIV-------------GGGYTPSKYAVEGFNDSL 190

Query: 215 AKRLQGTGVTTYAVHPGVVRSEL---VRHSSLLCLLWRLFSPFVK 256
            + ++  GV    + PG+ ++ L   V+       +W   SP +K
Sbjct: 191 RRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIK 235


>gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 62/225 (27%), Positives = 103/225 (45%), Gaps = 27/225 (12%)

Query: 40  KVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDL 99
           K + ITG ++G G   AR    +G  V  AC      ES ++ ++ +T + ++    LD+
Sbjct: 30  KYIFITGCDSGFGNLAARTFDKKGFHVIAACLT----ESGSTALKAET-SERLRTVLLDV 84

Query: 100 SDTKSIRAFAEGFLAE--EKQLHILINNAGV--MMCPYS-KTADGFETHLGVNHLGHFLL 154
           +D ++++  A+    +  EK L  LINNAGV  ++ P    T + +   + VN  G   +
Sbjct: 85  TDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISV 144

Query: 155 TYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFTREL 214
           T  +L  +K  A  RV+NVSSV   +  +             G  Y  SK A   F   L
Sbjct: 145 TLNMLPLVK-KAQGRVINVSSVGGRLAIV-------------GGGYTPSKYAVEGFNDSL 190

Query: 215 AKRLQGTGVTTYAVHPGVVRSEL---VRHSSLLCLLWRLFSPFVK 256
            + ++  GV    + PG+ ++ L   V+       +W   SP +K
Sbjct: 191 RRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIK 235


>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
           sapiens]
          Length = 270

 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 57/208 (27%), Positives = 87/208 (41%), Gaps = 22/208 (10%)

Query: 33  TNVQLPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQV 92
           T  +  GKVVV+TG   GIG    R   + GARV I  +D   G +   E+         
Sbjct: 3   TGTRYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQEL------PGA 56

Query: 93  LVRKLDLSDTKSIRAFAEGFLAEEKQLHILINNAG---VMMCPYSKTADGFETHLGVNHL 149
           +    D++    ++      +    +L  ++NNAG       P   +A GF   L +N L
Sbjct: 57  VFILCDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLL 116

Query: 150 GHFLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVL 209
           G + LT L L  L+ S    V+N+SS+   IG+            ++   Y  +K A   
Sbjct: 117 GTYTLTKLALPYLRKS-QGNVINISSLVGAIGQ------------AQAVPYVATKGAVTA 163

Query: 210 FTRELAKRLQGTGVTTYAVHPGVVRSEL 237
            T+ LA      GV    + PG + + L
Sbjct: 164 MTKALALDESPYGVRVNCISPGNIWTPL 191


>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
           sapiens]
          Length = 332

 Score = 62.4 bits (150), Expect = 5e-10
 Identities = 57/204 (27%), Positives = 94/204 (46%), Gaps = 13/204 (6%)

Query: 1   MLVTLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETARELA 60
           +L+    L +F   LYMV+P I            + LPG  VV+TG ++GIGK  A E  
Sbjct: 2   LLLAAAFLVAFVLLLYMVSPLISP--------KPLALPGAHVVVTGGSSGIGKCIAIECY 53

Query: 61  SRGARVYIACRDVLKGESAASEIRVDTKNSQ--VLVRKLDLS-DTKSIRAFAEGFLAEEK 117
            +GA + +  R+  K   A  EI + + N +  VL   +D+S D   +    +    +  
Sbjct: 54  KQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLG 113

Query: 118 QLHILINNAGVMMCPYSKTAD--GFETHLGVNHLGHFLLTYLLLERLKVSAPARVVNVSS 175
            + +L+N AG+ +    +  +   FE  + +N+LG    +  ++  +K     R+V VSS
Sbjct: 114 PVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSS 173

Query: 176 VAHHIGKIPFHDLQSEKRYSRGFA 199
            A  +G   F    + K   RG A
Sbjct: 174 QAGQLGLFGFTAYSASKFAIRGLA 197


>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
           [Homo sapiens]
          Length = 266

 Score = 61.6 bits (148), Expect = 9e-10
 Identities = 57/205 (27%), Positives = 94/205 (45%), Gaps = 23/205 (11%)

Query: 39  GKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLD 98
           GKV ++TGA  GIG+  A  L  +GA+V +   ++  G    + +    +  + L  + D
Sbjct: 5   GKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCD 64

Query: 99  LSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLL 158
           ++D + +R      +    +L IL+NNAGV           +E  L +N +     TYL 
Sbjct: 65  VADQQQLRDTFRKVVDHFGRLDILVNNAGV------NNEKNWEKTLQINLVSVISGTYLG 118

Query: 159 LERLKVSAPAR---VVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFTRE-- 213
           L+ +          ++N+SS+A   G +P          ++   YC SK   V FTR   
Sbjct: 119 LDYMSKQNGGEGGIIINMSSLA---GLMP---------VAQQPVYCASKHGIVGFTRSAA 166

Query: 214 LAKRLQGTGVTTYAVHPGVVRSELV 238
           LA  L  +GV   A+ PG V + ++
Sbjct: 167 LAANLMNSGVRLNAICPGFVNTAIL 191


>gi|4502601 carbonyl reductase 3 [Homo sapiens]
          Length = 277

 Score = 61.6 bits (148), Expect = 9e-10
 Identities = 67/266 (25%), Positives = 113/266 (42%), Gaps = 50/266 (18%)

Query: 40  KVVVITGANTGIGKETARELASR-GARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLD 98
           +V ++TGAN GIG   AREL  +    V +  RDV +G++A  +++ +  + +    +LD
Sbjct: 6   RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRF--HQLD 63

Query: 99  LSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLL 158
           + D +SIRA  +    E   L++L+NNA V            +  + +     F    + 
Sbjct: 64  IDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLK-TNFFATRNMC 122

Query: 159 LERLKVSAP-ARVVNVSSV--------------------------AHHIGKIPFHDLQSE 191
            E L +  P  RVVN+SS+                             + K    D ++E
Sbjct: 123 NELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNE 182

Query: 192 KRYSRGF---AYCHSKLANVLFTRELAKRL----QGTGVTTYAVHPGVVRSELVRHSSLL 244
                G+    Y  SKL   + +R LA+RL    +   +   A  PG V++++    S  
Sbjct: 183 VHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDS-- 240

Query: 245 CLLWRLFSPFVKTAREGAQTSLHCAL 270
                     ++T  EGA+T ++ AL
Sbjct: 241 ----------IRTVEEGAETPVYLAL 256


>gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B
           [Homo sapiens]
          Length = 264

 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 67/245 (27%), Positives = 100/245 (40%), Gaps = 54/245 (22%)

Query: 1   MLVTLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETARELA 60
           M + L +L    + +Y    S+ KFF   + +    + G++V+ITGA  GIG++T  E A
Sbjct: 1   MNIILEILLLLITIIYSYLESLVKFF---IPQRRKSVAGEIVLITGAGHGIGRQTTYEFA 57

Query: 61  SRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLH 120
            R +   +   D+ K +    ++ +   N+   V   DL  TK           EE    
Sbjct: 58  KRQS--ILVLWDINKVKKEVGDVTIVVNNAGT-VYPADLLSTKD----------EE---- 100

Query: 121 ILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLLLERLKVSAPARVVNVSSVAHHI 180
                        +KT +       VN LGHF +T  LL  +       +V V+SV  H 
Sbjct: 101 ------------ITKTFE-------VNILGHFWITKALLPSMMERNHGHIVTVASVCGHE 141

Query: 181 GKIPFHDLQSEKRYSRGFAYCHSKLANVLFTRELAKRLQG---TGVTTYAVHPGVVRSEL 237
           G IP+              YC SK A V F R L   LQ    TG+ T  + P  V +  
Sbjct: 142 G-IPYL-----------IPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGF 189

Query: 238 VRHSS 242
            ++ S
Sbjct: 190 TKNPS 194


>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
           sapiens]
          Length = 325

 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 57/214 (26%), Positives = 93/214 (43%), Gaps = 22/214 (10%)

Query: 32  RTNVQLPGKVVVITGANTGIGKETARELASRGARVYI------ACRDVLKGESAASEIRV 85
           R    L   VVVITGA +G+GKE A+   + GA++ +      A  ++++  +A+   +V
Sbjct: 45  RGKAYLRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKV 104

Query: 86  DTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLHILINNAGVMM--CPYSKTADGFETH 143
            T    ++    DL+D+ +I A A   L     + IL+NNAG+         T D  +  
Sbjct: 105 QTHKPYLVT--FDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRV 162

Query: 144 LGVNHLGHFLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHS 203
           +  N+ G   LT  LL  +       +V +SS+   +  IPF             AY  S
Sbjct: 163 METNYFGPVALTKALLPSMIKRRQGHIVAISSIQGKM-SIPFRS-----------AYAAS 210

Query: 204 KLANVLFTRELAKRLQGTGVTTYAVHPGVVRSEL 237
           K A   F   L   ++   +    + PG + + L
Sbjct: 211 KHATQAFFDCLRAEMEQYEIEVTVISPGYIHTNL 244


>gi|7705421 hydroxysteroid (17-beta) dehydrogenase 7 [Homo sapiens]
          Length = 341

 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 60/253 (23%), Positives = 105/253 (41%), Gaps = 37/253 (14%)

Query: 40  KVVVITGANTGIGKETARELASRGARVYI--ACRDVLKGESAASEIRVDTKNSQVLVRKL 97
           KVV+ITGA++GIG    + L +    +++  ACR++ K E+  + +      ++V + ++
Sbjct: 3   KVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHPTAEVTIVQV 62

Query: 98  DLSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCP-----------YSK----------- 135
           D+S+ +S+   ++      ++L  +  NAG+M  P           +S+           
Sbjct: 63  DVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPQLNIKALFFGLFSRKVIHMFSTAEG 122

Query: 136 --------TADGFETHLGVNHLGHFLLTYLLLERLKVS-APARVVNVSSVAHHIGKIPFH 186
                   TADG +     N  GHF+L   L   L  S  P++++  SS +         
Sbjct: 123 LLTQGDKITADGLQEVFETNVFGHFILIRELEPLLCHSDNPSQLIWTSSRSARKSNFSLE 182

Query: 187 DLQSEKRYSRGFAYCHSKLANVLFTRELAKRLQGTGVTTYAVHPGVVRSELVRHSSLLCL 246
           D Q  K       Y  SK A  L +  L +     G+ +    PG   + L  +  L   
Sbjct: 183 DFQHSKGKE---PYSSSKYATDLLSVALNRNFNQQGLYSNVACPGTALTNLT-YGILPPF 238

Query: 247 LWRLFSPFVKTAR 259
           +W L  P +   R
Sbjct: 239 IWTLLMPAILLLR 251


>gi|4502599 carbonyl reductase 1 [Homo sapiens]
          Length = 277

 Score = 56.2 bits (134), Expect = 4e-08
 Identities = 44/141 (31%), Positives = 68/141 (48%), Gaps = 11/141 (7%)

Query: 41  VVVITGANTGIGKETARELASR-GARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDL 99
           V ++TG N GIG    R+L       V +  RDV +G++A  +++ +  + +    +LD+
Sbjct: 7   VALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRF--HQLDI 64

Query: 100 SDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVN---HLGHFLLTY 156
            D +SIRA  +    E   L +L+NNAG+      K AD    H+          F    
Sbjct: 65  DDLQSIRALRDFLRKEYGGLDVLVNNAGIAF----KVADPTPFHIQAEVTMKTNFFGTRD 120

Query: 157 LLLERLKVSAP-ARVVNVSSV 176
           +  E L +  P  RVVNVSS+
Sbjct: 121 VCTELLPLIKPQGRVVNVSSI 141


>gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]
          Length = 303

 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 48/205 (23%), Positives = 92/205 (44%), Gaps = 18/205 (8%)

Query: 37  LPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVD---TKNSQVL 93
           L G+V ++TG  TGIGK   +EL   G+ V IA R + + +SAA E++ +   TK ++V+
Sbjct: 16  LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVI 75

Query: 94  VRKLDLSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSK--TADGFETHLGVNHLGH 151
             + ++ + + +    +  L    +++ L+NN G      ++  ++ G+   L  N  G 
Sbjct: 76  PIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGT 135

Query: 152 FLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFT 211
           F +              + V  S +  H G I    + ++  +        ++      T
Sbjct: 136 FYM-------------CKAVYSSWMKEHGGSIVNIIVPTKAGFPLAVHSGAARAGVYNLT 182

Query: 212 RELAKRLQGTGVTTYAVHPGVVRSE 236
           + LA     +G+    V PGV+ S+
Sbjct: 183 KSLALEWACSGIRINCVAPGVIYSQ 207


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.136    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,073,050
Number of Sequences: 37866
Number of extensions: 451284
Number of successful extensions: 983
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 58
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 880
Number of HSP's gapped (non-prelim): 79
length of query: 316
length of database: 18,247,518
effective HSP length: 102
effective length of query: 214
effective length of database: 14,385,186
effective search space: 3078429804
effective search space used: 3078429804
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.