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Search of human proteins with 112363080
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|112363080 microtubule associated serine/threonine kinase 2
[Homo sapiens]
(1798 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|112363080 microtubule associated serine/threonine kinase 2 [H... 3598 0.0
gi|45120119 microtubule associated serine/threonine kinase 1 [Ho... 1773 0.0
gi|148727255 microtubule associated serine/threonine kinase fami... 1678 0.0
gi|150170729 microtubule associated serine/threonine kinase 3 [H... 1479 0.0
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 233 1e-60
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 233 1e-60
gi|4502023 AKT2 kinase [Homo sapiens] 230 1e-59
gi|24307971 serine/threonine kinase 38 like [Homo sapiens] 228 4e-59
gi|62241015 AKT1 kinase [Homo sapiens] 228 5e-59
gi|62241013 AKT1 kinase [Homo sapiens] 228 5e-59
gi|62241011 AKT1 kinase [Homo sapiens] 228 5e-59
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 225 3e-58
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 225 3e-58
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ... 224 6e-58
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta... 224 6e-58
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 221 5e-57
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 220 1e-56
gi|5453976 protein kinase C, theta [Homo sapiens] 219 2e-56
gi|28557781 protein kinase C, eta [Homo sapiens] 219 2e-56
gi|6005814 serine/threonine kinase 38 [Homo sapiens] 219 2e-56
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 218 3e-56
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 218 4e-56
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 218 5e-56
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 218 5e-56
gi|5453974 protein kinase N2 [Homo sapiens] 218 5e-56
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho... 218 5e-56
gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo s... 217 9e-56
gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo sa... 217 9e-56
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 217 9e-56
gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo s... 215 3e-55
>gi|112363080 microtubule associated serine/threonine kinase 2 [Homo
sapiens]
Length = 1798
Score = 3598 bits (9330), Expect = 0.0
Identities = 1798/1798 (100%), Positives = 1798/1798 (100%)
Query: 1 MKRSRCRDRPQPPPPDRREDGVQRAAELSQSLPPRRRAPPGRQRLEERTGPAGPEGKEQD 60
MKRSRCRDRPQPPPPDRREDGVQRAAELSQSLPPRRRAPPGRQRLEERTGPAGPEGKEQD
Sbjct: 1 MKRSRCRDRPQPPPPDRREDGVQRAAELSQSLPPRRRAPPGRQRLEERTGPAGPEGKEQD 60
Query: 61 VVTGVSPLLFRKLSNPDIFSSTGKVKLQRQLSQDDCKLWRGNLASSLSGKQLLPLSSSVH 120
VVTGVSPLLFRKLSNPDIFSSTGKVKLQRQLSQDDCKLWRGNLASSLSGKQLLPLSSSVH
Sbjct: 61 VVTGVSPLLFRKLSNPDIFSSTGKVKLQRQLSQDDCKLWRGNLASSLSGKQLLPLSSSVH 120
Query: 121 SSVGQVTWQSSGEASNLVRMRNQSLGQSAPSLTAGLKELSLPRRGSFCRTSNRKSLIVTS 180
SSVGQVTWQSSGEASNLVRMRNQSLGQSAPSLTAGLKELSLPRRGSFCRTSNRKSLIVTS
Sbjct: 121 SSVGQVTWQSSGEASNLVRMRNQSLGQSAPSLTAGLKELSLPRRGSFCRTSNRKSLIVTS 180
Query: 181 STSPTLPRPHSPLHGHTGNSPLDSPRNFSPNAPAHFSFVPARRTDGRRWSLASLPSSGYG 240
STSPTLPRPHSPLHGHTGNSPLDSPRNFSPNAPAHFSFVPARRTDGRRWSLASLPSSGYG
Sbjct: 181 STSPTLPRPHSPLHGHTGNSPLDSPRNFSPNAPAHFSFVPARRTDGRRWSLASLPSSGYG 240
Query: 241 TNTPSSTVSSSCSSQEKLHQLPFQPTADELHFLTKHFSTESVPDEEGRQSPAMRPRSRSL 300
TNTPSSTVSSSCSSQEKLHQLPFQPTADELHFLTKHFSTESVPDEEGRQSPAMRPRSRSL
Sbjct: 241 TNTPSSTVSSSCSSQEKLHQLPFQPTADELHFLTKHFSTESVPDEEGRQSPAMRPRSRSL 300
Query: 301 SPGRSPVSFDSEIIMMNHVYKERFPKATAQMEERLAEFISSNTPDSVLPLADGALSFIHH 360
SPGRSPVSFDSEIIMMNHVYKERFPKATAQMEERLAEFISSNTPDSVLPLADGALSFIHH
Sbjct: 301 SPGRSPVSFDSEIIMMNHVYKERFPKATAQMEERLAEFISSNTPDSVLPLADGALSFIHH 360
Query: 361 QVIEMARDCLDKSRSGLITSQYFYELQDNLEKLLQDAHERSESSEVAFVMQLVKKLMIII 420
QVIEMARDCLDKSRSGLITSQYFYELQDNLEKLLQDAHERSESSEVAFVMQLVKKLMIII
Sbjct: 361 QVIEMARDCLDKSRSGLITSQYFYELQDNLEKLLQDAHERSESSEVAFVMQLVKKLMIII 420
Query: 421 ARPARLLECLEFDPEEFYHLLEAAEGHAKEGQGIKCDIPRYIVSQLGLTRDPLEEMAQLS 480
ARPARLLECLEFDPEEFYHLLEAAEGHAKEGQGIKCDIPRYIVSQLGLTRDPLEEMAQLS
Sbjct: 421 ARPARLLECLEFDPEEFYHLLEAAEGHAKEGQGIKCDIPRYIVSQLGLTRDPLEEMAQLS 480
Query: 481 SCDSPDTPETDDSIEGHGASLPSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAM 540
SCDSPDTPETDDSIEGHGASLPSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAM
Sbjct: 481 SCDSPDTPETDDSIEGHGASLPSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAM 540
Query: 541 KKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATL 600
KKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATL
Sbjct: 541 KKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATL 600
Query: 601 LKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIG 660
LKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIG
Sbjct: 601 LKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIG 660
Query: 661 LMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLV 720
LMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLV
Sbjct: 661 LMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLV 720
Query: 721 GCVPFFGDTPEELFGQVISDEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVK 780
GCVPFFGDTPEELFGQVISDEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVK
Sbjct: 721 GCVPFFGDTPEELFGQVISDEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVK 780
Query: 781 QHPFFTGLDWTGLLRQKAEFIPQLESEDDTSYFDTRSERYHHMDSEDEEEVSEDGCLEIR 840
QHPFFTGLDWTGLLRQKAEFIPQLESEDDTSYFDTRSERYHHMDSEDEEEVSEDGCLEIR
Sbjct: 781 QHPFFTGLDWTGLLRQKAEFIPQLESEDDTSYFDTRSERYHHMDSEDEEEVSEDGCLEIR 840
Query: 841 QFSSCSPRFNKVYSSMERLSLLEERRTPPPTKRSLSEEKEDHSDGLAGLKGRDRSWVIGS 900
QFSSCSPRFNKVYSSMERLSLLEERRTPPPTKRSLSEEKEDHSDGLAGLKGRDRSWVIGS
Sbjct: 841 QFSSCSPRFNKVYSSMERLSLLEERRTPPPTKRSLSEEKEDHSDGLAGLKGRDRSWVIGS 900
Query: 901 PEILRKRLSVSESSHTESDSSPPMTVRRRCSGLLDAPRFPEGPEEASSTLRRQPQEGIWV 960
PEILRKRLSVSESSHTESDSSPPMTVRRRCSGLLDAPRFPEGPEEASSTLRRQPQEGIWV
Sbjct: 901 PEILRKRLSVSESSHTESDSSPPMTVRRRCSGLLDAPRFPEGPEEASSTLRRQPQEGIWV 960
Query: 961 LTPPSGEGVSGPVTEHSGEQRPKLDEEAVGRSSGSSPAMETRGRGTSQLAEGATAKAISD 1020
LTPPSGEGVSGPVTEHSGEQRPKLDEEAVGRSSGSSPAMETRGRGTSQLAEGATAKAISD
Sbjct: 961 LTPPSGEGVSGPVTEHSGEQRPKLDEEAVGRSSGSSPAMETRGRGTSQLAEGATAKAISD 1020
Query: 1021 LAVRRARHRLLSGDSTEKRTARPVNKVIKSASATALSLLIPSEHHTCSPLASPMSPHSQS 1080
LAVRRARHRLLSGDSTEKRTARPVNKVIKSASATALSLLIPSEHHTCSPLASPMSPHSQS
Sbjct: 1021 LAVRRARHRLLSGDSTEKRTARPVNKVIKSASATALSLLIPSEHHTCSPLASPMSPHSQS 1080
Query: 1081 SNPSSRDSSPSRDFLPALGSMRPPIIIHRAGKKYGFTLRAIRVYMGDSDVYTVHHMVWHV 1140
SNPSSRDSSPSRDFLPALGSMRPPIIIHRAGKKYGFTLRAIRVYMGDSDVYTVHHMVWHV
Sbjct: 1081 SNPSSRDSSPSRDFLPALGSMRPPIIIHRAGKKYGFTLRAIRVYMGDSDVYTVHHMVWHV 1140
Query: 1141 EDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLENTSIKVGP 1200
EDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLENTSIKVGP
Sbjct: 1141 EDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLENTSIKVGP 1200
Query: 1201 ARKGSYKAKMARRSKRSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGES 1260
ARKGSYKAKMARRSKRSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGES
Sbjct: 1201 ARKGSYKAKMARRSKRSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGES 1260
Query: 1261 GPGSPTHSHSLSPRSPTQGYRVTPDAVHSVGGNSSQSSSPSSSVPSSPAGSGHTRPSSLH 1320
GPGSPTHSHSLSPRSPTQGYRVTPDAVHSVGGNSSQSSSPSSSVPSSPAGSGHTRPSSLH
Sbjct: 1261 GPGSPTHSHSLSPRSPTQGYRVTPDAVHSVGGNSSQSSSPSSSVPSSPAGSGHTRPSSLH 1320
Query: 1321 GLAPKLQRQYRSPRRKSAGSIPLSPLAHTPSPPPPTASPQRSPSPLSGHVAQAFPTKLHL 1380
GLAPKLQRQYRSPRRKSAGSIPLSPLAHTPSPPPPTASPQRSPSPLSGHVAQAFPTKLHL
Sbjct: 1321 GLAPKLQRQYRSPRRKSAGSIPLSPLAHTPSPPPPTASPQRSPSPLSGHVAQAFPTKLHL 1380
Query: 1381 SPPLGRQLSRPKSAEPPRSPLLKRVQSAEKLAAALAASEKKLATSRKHSLDLPHSELKKE 1440
SPPLGRQLSRPKSAEPPRSPLLKRVQSAEKLAAALAASEKKLATSRKHSLDLPHSELKKE
Sbjct: 1381 SPPLGRQLSRPKSAEPPRSPLLKRVQSAEKLAAALAASEKKLATSRKHSLDLPHSELKKE 1440
Query: 1441 LPPREVSPLEVVGARSVLSGKGALPGKGVLQPAPSRALGTLRQDRAERRESLQKQEAIRE 1500
LPPREVSPLEVVGARSVLSGKGALPGKGVLQPAPSRALGTLRQDRAERRESLQKQEAIRE
Sbjct: 1441 LPPREVSPLEVVGARSVLSGKGALPGKGVLQPAPSRALGTLRQDRAERRESLQKQEAIRE 1500
Query: 1501 VDSSEDDTEEGPENSQGAQELSLAPHPEVSQSVAPKGAGESGEEDPFPSRDPRSLGPMVP 1560
VDSSEDDTEEGPENSQGAQELSLAPHPEVSQSVAPKGAGESGEEDPFPSRDPRSLGPMVP
Sbjct: 1501 VDSSEDDTEEGPENSQGAQELSLAPHPEVSQSVAPKGAGESGEEDPFPSRDPRSLGPMVP 1560
Query: 1561 SLLTGITLGPPRMESPSGPHRRLGSPQAIEEAASSSSAGPNLGQSGATDPIPPEGCWKAQ 1620
SLLTGITLGPPRMESPSGPHRRLGSPQAIEEAASSSSAGPNLGQSGATDPIPPEGCWKAQ
Sbjct: 1561 SLLTGITLGPPRMESPSGPHRRLGSPQAIEEAASSSSAGPNLGQSGATDPIPPEGCWKAQ 1620
Query: 1621 HLHTQALTALSPSTSGLTPTSSCSPPSSTSGKLSMWSWKSLIEGPDRASPSRKATMAGGL 1680
HLHTQALTALSPSTSGLTPTSSCSPPSSTSGKLSMWSWKSLIEGPDRASPSRKATMAGGL
Sbjct: 1621 HLHTQALTALSPSTSGLTPTSSCSPPSSTSGKLSMWSWKSLIEGPDRASPSRKATMAGGL 1680
Query: 1681 ANLQDLENTTPAQPKNLSPREQGKTQPPSAPRLAHPSYEDPSQGWLWESECAQAVKEDPA 1740
ANLQDLENTTPAQPKNLSPREQGKTQPPSAPRLAHPSYEDPSQGWLWESECAQAVKEDPA
Sbjct: 1681 ANLQDLENTTPAQPKNLSPREQGKTQPPSAPRLAHPSYEDPSQGWLWESECAQAVKEDPA 1740
Query: 1741 LSITQVPDASGDRRQDVPCRGCPLTQKSEPSLRRGQEPGGHQKHRDLALVPDELLKQT 1798
LSITQVPDASGDRRQDVPCRGCPLTQKSEPSLRRGQEPGGHQKHRDLALVPDELLKQT
Sbjct: 1741 LSITQVPDASGDRRQDVPCRGCPLTQKSEPSLRRGQEPGGHQKHRDLALVPDELLKQT 1798
>gi|45120119 microtubule associated serine/threonine kinase 1 [Homo
sapiens]
Length = 1570
Score = 1773 bits (4593), Expect = 0.0
Identities = 991/1590 (62%), Positives = 1142/1590 (71%), Gaps = 129/1590 (8%)
Query: 148 SAPSLTAGLKELSLPRRGSFCRTSNRKSLIVTSSTSPTLPRPHSPLHGHTGNSPLDSPRN 207
S PS G S+ RR CRTSNRKSLI+TS TSPTLPRPHSPL GH G+SPLDSPRN
Sbjct: 13 SMPSFPGG----SMFRRTKSCRTSNRKSLILTS-TSPTLPRPHSPLPGHLGSSPLDSPRN 67
Query: 208 FSPNAPAHFSFVPARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPFQPTA 267
FSPN PAHFSF +RR DGRRWSLASLPSSGYGTNTPSSTVSSSCSSQE+LHQLP+QPT
Sbjct: 68 FSPNTPAHFSFASSRRADGRRWSLASLPSSGYGTNTPSSTVSSSCSSQERLHQLPYQPTV 127
Query: 268 DELHFLTKHF-STESVPDEEG-RQSPAMRPRSRSLSPGRSPVSFDSEIIMMNHVYKERFP 325
DELHFL+KHF STES+ DE+G R+SPA+RPRSRSLSPGRSP S+D+EI+MMNHVYKERFP
Sbjct: 128 DELHFLSKHFGSTESITDEDGGRRSPAVRPRSRSLSPGRSPSSYDNEIVMMNHVYKERFP 187
Query: 326 KATAQMEERLAEFISSNTPDSVLPLADGALSFIHHQVIEMARDCLDKSRSGLITSQYFYE 385
KATAQMEE+L +F + PDSVLPLADG LSFIHHQ+IE+ARDCL KSR GLIT+ YFYE
Sbjct: 188 KATAQMEEKLRDFTRAYEPDSVLPLADGVLSFIHHQIIELARDCLTKSRDGLITTVYFYE 247
Query: 386 LQDNLEKLLQDAHERSESSEVAFVMQLVKKLMIIIARPARLLECLEFDPEEFYHLLEAAE 445
LQ+NLEKLLQDA+ERSES EVAFV QLVKKL+III+RPARLLECLEF+PEEFYHLLEAAE
Sbjct: 248 LQENLEKLLQDAYERSESLEVAFVTQLVKKLLIIISRPARLLECLEFNPEEFYHLLEAAE 307
Query: 446 GHAKEGQGIKCDIPRYIVSQLGLTRDPLEEMAQLSSCDS--PDTPETDDSIEGHGASLPS 503
GHAKEG +K DIPRYI+ QLGLTRDP ++ L DS +TPE DD EG + +
Sbjct: 308 GHAKEGHLVKTDIPRYIIRQLGLTRDPFPDVVHLEEQDSGGSNTPEQDDLSEGRSSK--A 365
Query: 504 KKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDI 563
KK P E DF+TIKLISNGAYGAV+LVRH+ TRQRFAMKKINKQNLILRNQIQQAFVERDI
Sbjct: 366 KKPPGENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDI 425
Query: 564 LTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLAL 623
LTFAENPFVV MFCSF+T+RHLCMVMEYVEGGDCATLLKNIGALPV+M R+YFAETVLAL
Sbjct: 426 LTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLAL 485
Query: 624 EYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDK 683
EYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSK+GLMSLTTNLYEGHIEKDAREFLDK
Sbjct: 486 EYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDK 545
Query: 684 QVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIV 743
QVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISD+I+
Sbjct: 546 QVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDIL 605
Query: 744 WPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAEFIPQ 803
WPEGDEALP +AQ L S LL NPL RLG G A+EVKQH FF LDWTGLLRQKAEFIP
Sbjct: 606 WPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKAEFIPH 665
Query: 804 LESEDDTSYFDTRSERYHHMDSEDEEEVSEDGCLEIRQFSSCSPRFNKVYSSMERLSLLE 863
LESEDDTSYFDTRS+RYHH++S DE++ +E+ +EIRQFSSCSPRF+KVYSSME+LS
Sbjct: 666 LESEDDTSYFDTRSDRYHHVNSYDEDDTTEEEPVEIRQFSSCSPRFSKVYSSMEQLS-QH 724
Query: 864 ERRTP---------PPTKRSLSEEKEDHSDGLAGLKGRDRSWVIGSPEILRKRLSVSESS 914
E +TP P+ + E+ +GL GL R+++W GSPEI KR S SE+S
Sbjct: 725 EPKTPVAAAGSSKREPSTKGPEEKVAGKREGLGGLTLREKTWRGGSPEI--KRFSASEAS 782
Query: 915 HTESDSSPPMTVRRRCSGLLDAPRFPEGPE-EASSTLRRQPQEGIWVLTPPSGEGVSGPV 973
E ++SPP+ RRR S LL+ RF E E + LRR P+ + P+G
Sbjct: 783 FLEGEASPPLGARRRFSALLEPSRFSAPQEDEDEARLRRPPRPS----SDPAGS------ 832
Query: 974 TEHSGEQRPKLDEEAVGRSS-GSSPAMETRGRG----TSQLAEGATAKAISDLAVRRARH 1028
+ PK + + G SS G S A + G S+ + + +A +DL +RRARH
Sbjct: 833 ---LDARAPKEETQGEGTSSAGDSEATDRPRPGDLCPPSKDGDASGPRATNDLVLRRARH 889
Query: 1029 RLLSGD-STEKRTARPVNKVIKSASATALSLLIPS-EHHTCSPLASPMSPHSQSSNPSSR 1086
+ +SGD + EKR +R KVIKSASATALS++IP+ + H SPLASPMSP S SSNPSSR
Sbjct: 890 QQMSGDVAVEKRPSRTGGKVIKSASATALSVMIPAVDPHGSSPLASPMSPRSLSSNPSSR 949
Query: 1087 DSSPSRDFLPALGSMRPPIIIHRAGKKYGFTLRAIRVYMGDSDVYTVHHMVWHVEDGGPA 1146
DSSPSRD+ PA+ +R PI I R+GKKYGFTLRAIRVYMGD+DVY+VHH+VWHVE+GGPA
Sbjct: 950 DSSPSRDYSPAVSGLRSPITIQRSGKKYGFTLRAIRVYMGDTDVYSVHHIVWHVEEGGPA 1009
Query: 1147 SEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLENTSIKVGPARKGSY 1206
EAGL GDLITHVNGEPVHG+VH EVVELILKSGNKVA++TTP ENTSI++GPAR+ SY
Sbjct: 1010 QEAGLCAGDLITHVNGEPVHGMVHPEVVELILKSGNKVAVTTTPFENTSIRIGPARRSSY 1069
Query: 1207 KAKMARRSKRSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGESGPGSPT 1266
KAKMARR+KR K+GQES+KRSSLFRKITKQ++LLHTSRSLSSLNRSLSS +S PGSPT
Sbjct: 1070 KAKMARRNKRPSAKEGQESKKRSSLFRKITKQSNLLHTSRSLSSLNRSLSSSDSLPGSPT 1129
Query: 1267 HSHSLSPRSPTQGYRVTPDAVHSVGGNSSQSSSPSSSVPSSPAGSG--HTRPSSLHGLAP 1324
H L RSPT YR TPD+ + G SSQSSSP+SS P+SPA S H RPS+LHGL+P
Sbjct: 1130 --HGLPARSPTHSYRSTPDSAYL--GASSQSSSPASSTPNSPASSASHHIRPSTLHGLSP 1185
Query: 1325 KLQRQYRSPRRKSAGSIPLSPLAHTPSPPPPTASPQRSPSPLSGHVAQAFPTKLHLSPPL 1384
KL RQYRS R KSAG+IPLSPLAHTPSP + P + S H Q+FP KLH SPP+
Sbjct: 1186 KLHRQYRSARCKSAGNIPLSPLAHTPSPTQASPPPLPGHTVGSSHTTQSFPAKLHSSPPV 1245
Query: 1385 GRQLSRPKSAEPPRSPLLKRVQSAEKLAAALAASEKKLATSRKHSLDLPHSELKK----- 1439
R RPKSAEPPRSPLLKRVQSAEKL A+L+A +K RKHSL++ H + +K
Sbjct: 1246 VR--PRPKSAEPPRSPLLKRVQSAEKLGASLSADKK--GALRKHSLEVGHPDFRKDFHGE 1301
Query: 1440 -----------ELPP----------------REVSPLEV--------VGARSVLSGKGAL 1464
E PP R+ SPL + +R +S K
Sbjct: 1302 LALHSLAESDGETPPVEGLGAPRQVAVRRLGRQESPLSLGADPLLPEGASRPPVSSKEKE 1361
Query: 1465 PGKGVLQPAPSRAL----GTLRQD-RAERRESLQKQE--------AIREVDSSEDDTEEG 1511
G P RA TL +D R +S+Q ++ + S + E G
Sbjct: 1362 SPGGAEACTPPRATTPGGRTLERDVGCTRHQSVQTEDGTGGMARAVAKAALSPVQEHETG 1421
Query: 1512 PENSQGAQELSLAP------HPEVSQSV-APKGAGESGEEDPFPSRDPRSLGPMVPSLLT 1564
+S G L P P V P GA G ++P P L P VP
Sbjct: 1422 RRSSSGEAGTPLVPIVVEPARPGAKAVVPQPLGADSKGLQEPAP------LAPSVPEAPR 1475
Query: 1565 G----ITLGPPRMESPSGPHRRLGSPQAIEEAASSSSAGPNL-GQSGATDPIPPEGCWKA 1619
G + + SGP + SP+ E + S A S A P+PP +
Sbjct: 1476 GRERWVLEVVEERTTLSGPRSKPASPKLSPEPQTPSLAPAKCSAPSSAVTPVPPASLLGS 1535
Query: 1620 QHLHTQALTALSPS----TSGLTPTSSCSP 1645
LT+ P+ +GLT SP
Sbjct: 1536 GTKPQVGLTSRCPAEAVPPAGLTKKGVSSP 1565
>gi|148727255 microtubule associated serine/threonine kinase family
member 4 isoform a [Homo sapiens]
Length = 2434
Score = 1678 bits (4345), Expect = 0.0
Identities = 926/1454 (63%), Positives = 1073/1454 (73%), Gaps = 100/1454 (6%)
Query: 157 KELSLPRRGSF------------CRTSNRKSLIVTSSTSPTLPRPHSPLHGHTGNSPLDS 204
KELSLPRRGS CRTSNRKSLI + SP LPRPHSPL H GNSP DS
Sbjct: 14 KELSLPRRGSLIDSQKWNCLVKRCRTSNRKSLI-GNGQSPALPRPHSPLSAHAGNSPQDS 72
Query: 205 PRNFSPNAPAHFSFVPARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPFQ 264
PRNFSP+A AHFSF ARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLP+Q
Sbjct: 73 PRNFSPSASAHFSF--ARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPYQ 130
Query: 265 PTADELHFLTKHF-STESVPDEEGRQSPAMRPRSRSLSPGRSPVSFDSEIIMMNHVYKER 323
PT DELHFL+KHF +TES+ E ++ MRPRSRSLSPGRSP D EIIMMNHVYKER
Sbjct: 131 PTPDELHFLSKHFCTTESIATENRCRNTPMRPRSRSLSPGRSPACCDHEIIMMNHVYKER 190
Query: 324 FPKATAQMEERLAEFISSNTPDSVLPLADGALSFIHHQVIEMARDCLDKSRSGLITSQYF 383
FPKATAQMEERL E I+S +PD+VLPLADG LSF HHQ+IE+ARDCLDKS GLITS+YF
Sbjct: 191 FPKATAQMEERLKEIITSYSPDNVLPLADGVLSFTHHQIIELARDCLDKSHQGLITSRYF 250
Query: 384 YELQDNLEKLLQDAHERSESSEVAFVMQLVKKLMIIIARPARLLECLEFDPEEFYHLLEA 443
ELQ L+KLLQ+AH+RSES E+AF+ QLV+K++I+IARPARLLECLEFDPEEFY+LLEA
Sbjct: 251 LELQHKLDKLLQEAHDRSESGELAFIKQLVRKILIVIARPARLLECLEFDPEEFYYLLEA 310
Query: 444 AEGHAKEGQGIKCDIPRYIVSQLGLTRDPLEEMAQLSSCDS--PDTPETDDSIEGHGASL 501
AEGHAKEGQGIK DIPRYI+SQLGL +DPLEEMA L + DS +TPETD+S+ ASL
Sbjct: 311 AEGHAKEGQGIKTDIPRYIISQLGLNKDPLEEMAHLGNYDSGTAETPETDESVSSSNASL 370
Query: 502 PSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVER 561
++ P E DFETIKLISNGAYGAV+ VRHK +RQRFAMKKINKQNLILRNQIQQAFVER
Sbjct: 371 KLRRKPRESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVER 430
Query: 562 DILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVL 621
DILTFAENPFVVSM+CSF+T+RHLCMVMEYVEGGDCATL+KN+G LPVDM R+YFAETVL
Sbjct: 431 DILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVL 490
Query: 622 ALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFL 681
ALEYLHNYGIVHRDLKPDNLL+TSMGHIKLTDFGLSK+GLMS+TTNLYEGHIEKDAREFL
Sbjct: 491 ALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFL 550
Query: 682 DKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDE 741
DKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDE
Sbjct: 551 DKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDE 610
Query: 742 IVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAEFI 801
I WPE DEA PPDAQDL + LL QNPLERLGTG AYEVKQH FF LDW LLRQKAEFI
Sbjct: 611 INWPEKDEAPPPDAQDLITLLLRQNPLERLGTGGAYEVKQHRFFRSLDWNSLLRQKAEFI 670
Query: 802 PQLESEDDTSYFDTRSERYHHMDSEDEEEVS-EDGCLEIRQFSSCSPRFNKVYSSMERLS 860
PQLESEDDTSYFDTRSE+YHHM++E+E++ + ED +EIRQFSSCS RF+KV+SS++R++
Sbjct: 671 PQLESEDDTSYFDTRSEKYHHMETEEEDDTNDEDFNVEIRQFSSCSHRFSKVFSSIDRIT 730
Query: 861 LLEERRTPPPTKRSLSEEKEDHSDGLAGLKGRDRSWVIGSPEIL--------RKRLSVSE 912
++ +EEKED D + +S + S E L ++LS S
Sbjct: 731 ------------QNSAEEKEDSVD-------KTKSTTLPSTETLSWSSEYSEMQQLSTSN 771
Query: 913 SSHTESDSSPPMTVRRRCSGLLDAPRFPEGPEEASSTLRRQPQEGIWVLTPPSGEGVSGP 972
SS TES+ + SGLL P+ A ST Q + P G
Sbjct: 772 SSDTESNR------HKLSSGLL--------PKLAISTEGEQDEAASCPGDPHEEPGKPAL 817
Query: 973 VTEHSGEQRPKLDEEAVGRSSG-------SSPAMETRGRGTSQLAEGATAKAISDLAVRR 1025
E ++ P++ A SS S + GR + ++K S+ A
Sbjct: 818 PPEECAQEEPEVTTPASTISSSTLSVGSFSEHLDQINGRSECVDSTDNSSKPSSEPASHM 877
Query: 1026 ARHRLLSGDSTEKRTARPVNKVIKSASATALSLLIPSEHHTCSPLASPMSPHSQSSNP-S 1084
AR RL +STEK+ + KV KS SA+ALSL+IP + SPL SPMSPHS SS+P S
Sbjct: 878 ARQRL---ESTEKK--KISGKVTKSLSASALSLMIPGDMFAVSPLGSPMSPHSLSSDPSS 932
Query: 1085 SRDSSPSRDFLPALGSMRPPIIIHRAGKKYGFTLRAIRVYMGDSDVYTVHHMVWHVEDGG 1144
SRDSSPSRD A S PI+IH +GK YGFT+RAIRVY+GDSD+YTVHH+VW+VE+G
Sbjct: 933 SRDSSPSRDSSAASASPHQPIVIHSSGKNYGFTIRAIRVYVGDSDIYTVHHIVWNVEEGS 992
Query: 1145 PASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLENTSIKVGPARKG 1204
PA +AGL+ GDLITH+NGEPVHGLVHTEV+EL+LKSGNKV+I+TTP ENTSIK GPAR+
Sbjct: 993 PACQAGLKAGDLITHINGEPVHGLVHTEVIELLLKSGNKVSITTTPFENTSIKTGPARRN 1052
Query: 1205 SYKAKMARRSKRSRGKDGQESRKRSSLFRKITKQAS-LLHTSRSLSSLNRSLSSGESGPG 1263
SYK++M RRSK+S+ K+ E +R SLF+K+ KQ S LLHTSRS S LNRSLSSGES PG
Sbjct: 1053 SYKSRMVRRSKKSKKKESLE--RRRSLFKKLAKQPSPLLHTSRSFSCLNRSLSSGESLPG 1110
Query: 1264 SPTHSHSLSPRSPTQGYRVTPDAVHSVGGNSSQSSSPSSSVPSSPAGSGHTRPSSLHGLA 1323
SPT HSLSPRSPT YR TPD G NSSQSSSPSSS P+SPAGSGH RPS+LHGLA
Sbjct: 1111 SPT--HSLSPRSPTPSYRSTPD--FPSGTNSSQSSSPSSSAPNSPAGSGHIRPSTLHGLA 1166
Query: 1324 PKLQRQ-YRSPRRKSAGSIPLSPLAHTPSPPPPTASPQRSPSPLSGH------VAQAFPT 1376
PKL Q YRS RRKSAG+IPLSPLA TPSP P SPQRSPSPL GH +AQAFP+
Sbjct: 1167 PKLGGQRYRSGRRKSAGNIPLSPLARTPSPTPQPTSPQRSPSPLLGHSLGNSKIAQAFPS 1226
Query: 1377 KLHLSPPLGRQLSRPKSAEPPRSPLLKRVQSAEKLAAALAASEKKLATSRKHSLDLPHSE 1436
K+H P + R + RPKSAEPPRSPLLKRVQS EKL+ + S+KK SRKHSL++ E
Sbjct: 1227 KMHSPPTIVRHIVRPKSAEPPRSPLLKRVQSEEKLSPSY-GSDKKHLCSRKHSLEVTQEE 1285
Query: 1437 LKKELPPREVSPLEVVGAR--SVLSGKGALP-GKGVLQPAPSRALGTLRQDRAERRESLQ 1493
+++E RE +PL+ + V A P +G L+ SR +G R+ L+
Sbjct: 1286 VQREQSQRE-APLQSLDENVCDVPPLSRARPVEQGCLKRPVSRKVGRQESVDDLDRDKLK 1344
Query: 1494 KQEAIREVDSSEDDTEEGPENSQG----AQELSLAPHPEVSQSVAPKGAGESGEEDPFPS 1549
+ +++ D + +E + S G + +L E + V PK S F +
Sbjct: 1345 AKVVVKKADGF-PEKQESHQKSHGPGSDLENFALFKLEEREKKVYPKAVERS---STFEN 1400
Query: 1550 RDPRSLGPMVPSLL 1563
+ P + SLL
Sbjct: 1401 KASMQEAPPLGSLL 1414
Score = 36.2 bits (82), Expect = 0.30
Identities = 118/504 (23%), Positives = 172/504 (34%), Gaps = 71/504 (14%)
Query: 1252 NRSLSSGESGPGS--PTHSHSLSP--RSPTQGYRVTPDAVHSVGGNSSQSSSPSSSVPSS 1307
N + S+ E P S S+ L P P++G + +P AV + S
Sbjct: 1662 NDTTSARELSPSSLKMNKSYLLEPWFLPPSRGLQNSP-AVSLPDPEFKRDRKGPHPTARS 1720
Query: 1308 PAGSGHTRPSSLHGLAPKLQRQYRSPRRKSA-GSIPLSP-LAHTPSPPPPTASPQRSPSP 1365
P + P G +PK Q P+ + G SP LA P PP ASP R
Sbjct: 1721 PGTVMESNPQQREGSSPKHQDHTTDPKLLTCLGQNLHSPDLARPRCPLPPEASPSREKPG 1780
Query: 1366 LSGHVAQAFPTKLHLSPPLGRQLSRPKSAEPPRSPLLKRVQSAEKLAAA----------L 1415
L + PT R S E K +++ L +
Sbjct: 1781 LRESSERGPPTARSERSAARADTCREPSMELCFPETAKTSDNSKNLLSVGRTHPDFYTQT 1840
Query: 1416 AASEKKLATSRKHSLDLPHSELKKELPPREVSPLEVVGARSVLSGKGALPGKGVLQPAPS 1475
A EK A K + E + PPR+ S L G + K + ++P P
Sbjct: 1841 QAMEKAWAPGGKTNHKDGPGEARP--PPRDNSSLHSAG---IPCEKELGKVRRGVEPKPE 1895
Query: 1476 RALGTLRQDRAERRESLQKQEAIREVDSSEDDTEEGPENSQGAQELSLAPHPEVSQSVAP 1535
L R+ +K E + S + D + PE +E L HP S+ P
Sbjct: 1896 ALLA--RRSLQPPGIESEKSEKLSSFPSLQKDGAKEPER----KEQPLQRHP---SSIPP 1946
Query: 1536 KGAGESGEEDPFPSRDPRSLGPMVPSLLTGITLG--PPRMESPSGPHRRLGSPQAIEEAA 1593
P + S PS +G G P E S P P+ + +
Sbjct: 1947 PPLTAKDLSSPAARQHCSS-----PSHASGREPGAKPSTAEPSSSPQ---DPPKPVAAHS 1998
Query: 1594 SSSSAGPNLGQSGATDPIPPEGCWKAQHLHTQALTALSPS---TSGLTPTSSCSPPSSTS 1650
SSS P G DP PP K +H ++L++ PS T G P + SS
Sbjct: 1999 ESSSHKPRPG----PDPGPP----KTKH-PDRSLSSQKPSVGATKGKEPATQSLGGSSRE 2049
Query: 1651 GKLSMWSWKSLIEGPD--RASPSRKATMAGGLANLQ---DLENTTPAQPKNLSPRE---- 1701
GK S GPD A+P + + G+ + + T P + P+
Sbjct: 2050 GKGHSKS------GPDVFPATPGSQNKASDGIGQGEGGPSVPLHTDRAPLDAKPQPTSGG 2103
Query: 1702 ---QGKTQPPSAPRLAHPSYEDPS 1722
+ +P PR HP +P+
Sbjct: 2104 RPLEVLEKPVHLPRPGHPGPSEPA 2127
>gi|150170729 microtubule associated serine/threonine kinase 3 [Homo
sapiens]
Length = 1309
Score = 1479 bits (3830), Expect = 0.0
Identities = 833/1405 (59%), Positives = 986/1405 (70%), Gaps = 135/1405 (9%)
Query: 157 KELSLPRRGSFCRTSNRKSLIVTSSTSPTLPRPHSPLHGHT-GNSPLDSPRNFSPNAPAH 215
KELSLPRRG CR+ NRKSL+V + SPTL RP SPL T G+SPLDSPRNFS + +
Sbjct: 14 KELSLPRRGRGCRSGNRKSLVV-GTPSPTLSRPLSPLSVPTAGSSPLDSPRNFSAASALN 72
Query: 216 FSFVPARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPFQPTADELHFLTK 275
F F ARR DGRRWSLASLPSSGYGTNTPSST+SSS SS+E+LHQLPFQPT DELHFL+K
Sbjct: 73 FPF--ARRADGRRWSLASLPSSGYGTNTPSSTLSSSSSSRERLHQLPFQPTPDELHFLSK 130
Query: 276 HF-STESVPDEEGRQSPAMRPRSRSLSPGRSPVSFDSEIIMMNHVYKERFPKATAQMEER 334
HF S+E+V DEEG +SP +RPRSRSLSPGR+ +FD+EI+MMNHVY+ERFPKATAQME R
Sbjct: 131 HFRSSENVLDEEGGRSPRLRPRSRSLSPGRATGTFDNEIVMMNHVYRERFPKATAQMEGR 190
Query: 335 LAEFISSNTPDSVLPLADGALSFIHHQVIEMARDCLDKSRSGLITSQYFYELQDNLEKLL 394
L EF+++ P + L LADG L FIHHQ++E+ARDCL KS L+TS+YF E+Q+ LE+LL
Sbjct: 191 LQEFLTAYAPGARLALADGVLGFIHHQIVELARDCLAKSGENLVTSRYFLEMQEKLERLL 250
Query: 395 QDAHERSESSEVAFVMQLVKKLMIIIARPARLLECLEFDPEEFYHLLEAAEGHAKEGQGI 454
QDAHERS+S EV+F++QLV+KL+III+RPARLLECLEFDPEEFYHLLEAAEGHA+EGQGI
Sbjct: 251 QDAHERSDSEEVSFIVQLVRKLLIIISRPARLLECLEFDPEEFYHLLEAAEGHAREGQGI 310
Query: 455 KCDIPRYIVSQLGLTRDPLEEMAQLSSCDSPDTPETDDSIEGHGASLPSKKTPSEEDFET 514
K D+P+YI+ QLGL +DPLEEM LS + + P +S E S++ P E DFET
Sbjct: 311 KTDLPQYIIGQLGLAKDPLEEMVPLSHLEE-EQPPAPESPESRALVGQSRRKPCESDFET 369
Query: 515 IKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVS 574
IKLISNGAYGAV+LVRH+ TRQRFA+KKINKQNLILRNQIQQ FVERDILTFAENPFVVS
Sbjct: 370 IKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVS 429
Query: 575 MFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHR 634
MFCSF+T+RHLCMVMEYVEGGDCATLLKN+G LPVDM RLYFAETVLALEYLHNYGIVHR
Sbjct: 430 MFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYGIVHR 489
Query: 635 DLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAP 694
DLKPDNLLITS+GHIKLTDFGLSKIGLMS+ TNLYEGHIEKDAREF+DKQVCGTPEYIAP
Sbjct: 490 DLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTPEYIAP 549
Query: 695 EVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDEALPPD 754
EVI RQGYGKPVDWWAMG++LYEFLVGCVPFFGDTPEELFGQV+SDEI+WPEGDEALP D
Sbjct: 550 EVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEALPAD 609
Query: 755 AQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAEFIPQLESEDDTSYFD 814
AQDL ++LL Q+PL+RLGTG +EVKQHPFF LDW GLLR KAEF+PQLE+EDDTSYFD
Sbjct: 610 AQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEFVPQLEAEDDTSYFD 669
Query: 815 TRSERYHHMDSEDEEEVSEDGCLEIRQFSSCSPRFNKVYSSMERLSLLEERRTPPPTKRS 874
TRSERY H+ SED+E E+ EI QFSSCS RF+KVYSS E L++ + TP +RS
Sbjct: 670 TRSERYRHLGSEDDETNDEESSTEIPQFSSCSHRFSKVYSSSEFLAV---QPTPTFAERS 726
Query: 875 LSEEKEDHSDGLAGLKGRDRSWVIGSPEI---LRKRLSVSESSHTESDSSPPMTVRRRCS 931
SE++E+ G +RS V + +R R S S +S SS P R
Sbjct: 727 FSEDREE---------GWERSEVDYGRRLSADIRLRSWTSSGSSCQSSSSQP--ERGPSP 775
Query: 932 GLLDA------PRFP-EGPEEASSTLRRQPQEGIWVLTPPSGEGVSGPV--------TEH 976
LL+ P+F +E P+ +++L P + PV +
Sbjct: 776 SLLNTISLDTMPKFAFSSEDEGVGPGPAGPKRPVFILGEPDPPPAATPVMPKPSSLSADT 835
Query: 977 SGEQRPKLDEEAVG-RSSGSSPAMETRGRGTSQLAEGATAKAISDLAVRRARHRLLSGDS 1035
+ +L ++G R S P RGR + A K+ RA SG
Sbjct: 836 AALSHARLRSNSIGARHSTPRPLDAGRGRRLGGPRDPAPEKS-------RASSSGGSGGG 888
Query: 1036 TEKRTARPVNKVIKSASATALSLLIPSEHHTCSPLASPMSPHSQSSNPSSRDSSPSRDFL 1095
+ R V KSAS +ALSL+I ++ + PL SP+SP S SSNPSSRDSSPSRD
Sbjct: 889 SGGR-------VPKSASVSALSLIITADDGSGGPLMSPLSPRSLSSNPSSRDSSPSRDPS 941
Query: 1096 PALGSMRPPIIIHRAGKKYGFTLRAIRVYMGDSDVYTVHHMVWHVEDGGPASEAGLRQGD 1155
P GS+RPPI+IH +GKKYGF+LRAIRVYMGDSDVYTVHH+VW VEDG PA EAGLR GD
Sbjct: 942 PVCGSLRPPIVIHSSGKKYGFSLRAIRVYMGDSDVYTVHHVVWSVEDGSPAQEAGLRAGD 1001
Query: 1156 LITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLENTSIKVGPARKGSYKAKMARRSK 1215
LITH+NGE V GLVH +VVEL+LKSGNK+++ TT LENTSIKVGPARK K +MARRSK
Sbjct: 1002 LITHINGESVLGLVHMDVVELLLKSGNKISLRTTALENTSIKVGPARKNVAKGRMARRSK 1061
Query: 1216 RSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSS-LNRSLSSGESGPGSPTHSHSLSPR 1274
RSR ++ Q+ RK SLF+KI+KQ S+LHTSRS SS L+ SLSS ES PGSPTHS S SP
Sbjct: 1062 RSRRRETQDRRK--SLFKKISKQTSVLHTSRSFSSGLHHSLSSSESLPGSPTHSLSPSPT 1119
Query: 1275 SPTQGYRVTPDAVHSVGGNSSQSSSPSSSVPSSPAGSGHTRPSSLHGLAPKL-QRQYRSP 1333
+P + PD V + S S+SPSSS P+SPA +GHTRPSSLHGLA KL + ++
Sbjct: 1120 TPCRS--PAPD-VPADTTASPPSASPSSSSPASPAAAGHTRPSSLHGLAAKLGPPRPKTG 1176
Query: 1334 RRKSAGSIPLSPLAHTPSPPPPTASPQRSPSPLSGHVAQAFPTKLHLSPPLGRQLSRPKS 1393
RRKS SIP SPLA PP +A P RSPSPL GH PP
Sbjct: 1177 RRKSTSSIPPSPLA----CPPISAPPPRSPSPLPGH------------PP---------- 1210
Query: 1394 AEPPRSPLLKRVQSAEKLAAALAASEKKLATSRKHSLDLPHSELKKELPPREVSPLEVVG 1453
P RSP L+R QSA+KL G
Sbjct: 1211 -APARSPRLRRGQSADKL-----------------------------------------G 1228
Query: 1454 ARSVLSGKGALPGKGVLQPAPSRALGTLRQ-DRAERRESLQKQEAIREVDSSEDDTEEGP 1512
L G+ +G P L +R+ +ERR+S +KQEA++EV S ++ EE
Sbjct: 1229 TGERLDGEAGRRTRG-----PEAELVVMRRLHLSERRDSFKKQEAVQEV-SFDEPQEEAT 1282
Query: 1513 ENSQGAQELSLAPHPEVSQSVAPKG 1537
++++ V ++ P G
Sbjct: 1283 GLPTSVPQIAVEGEEAVPVALGPTG 1307
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 233 bits (594), Expect = 1e-60
Identities = 130/335 (38%), Positives = 189/335 (56%), Gaps = 22/335 (6%)
Query: 484 SPDTPETDDSIEGHGASLPSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKI 543
SP + + E AS K + DF+ +KL+ G +G V LVR K++ + +AMK +
Sbjct: 120 SPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKIL 179
Query: 544 NKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKN 603
K+ +I ++++ E +L +PF+ S+ SF TK LC VMEYV GG+ L
Sbjct: 180 KKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSR 239
Query: 604 IGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMS 663
D R Y AE V AL+YLH+ IV+RDLK +NL++ GHIK+TDFGL K G+
Sbjct: 240 ERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITD 299
Query: 664 LTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCV 723
T K CGTPEY+APEV+ YG+ VDWW +G+++YE + G +
Sbjct: 300 AATM---------------KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 344
Query: 724 PFFGDTPEELFGQVISDEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTG--SAYEVKQ 781
PF+ E+LF ++ ++I +P L DA+ L S LL ++P +RLG G A E+ +
Sbjct: 345 PFYNQDHEKLFELILMEDIKFP---RTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMR 401
Query: 782 HPFFTGLDWTGLLRQK--AEFIPQLESEDDTSYFD 814
H FF+G++W + +K F PQ+ SE DT YFD
Sbjct: 402 HSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFD 436
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 233 bits (594), Expect = 1e-60
Identities = 130/335 (38%), Positives = 189/335 (56%), Gaps = 22/335 (6%)
Query: 484 SPDTPETDDSIEGHGASLPSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKI 543
SP + + E AS K + DF+ +KL+ G +G V LVR K++ + +AMK +
Sbjct: 120 SPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKIL 179
Query: 544 NKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKN 603
K+ +I ++++ E +L +PF+ S+ SF TK LC VMEYV GG+ L
Sbjct: 180 KKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSR 239
Query: 604 IGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMS 663
D R Y AE V AL+YLH+ IV+RDLK +NL++ GHIK+TDFGL K G+
Sbjct: 240 ERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITD 299
Query: 664 LTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCV 723
T K CGTPEY+APEV+ YG+ VDWW +G+++YE + G +
Sbjct: 300 AATM---------------KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 344
Query: 724 PFFGDTPEELFGQVISDEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTG--SAYEVKQ 781
PF+ E+LF ++ ++I +P L DA+ L S LL ++P +RLG G A E+ +
Sbjct: 345 PFYNQDHEKLFELILMEDIKFP---RTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMR 401
Query: 782 HPFFTGLDWTGLLRQK--AEFIPQLESEDDTSYFD 814
H FF+G++W + +K F PQ+ SE DT YFD
Sbjct: 402 HSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFD 436
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 230 bits (586), Expect = 1e-59
Identities = 126/337 (37%), Positives = 190/337 (56%), Gaps = 24/337 (7%)
Query: 482 CDSPDTPETDDSIEGHGASLPSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMK 541
C SP T + +E + +K T + DF+ +KL+ G +G V LVR K+T + +AMK
Sbjct: 124 CGSPSDSSTTEEMEVAVSKARAKVTMN--DFDYLKLLGKGTFGKVILVREKATGRYYAMK 181
Query: 542 KINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLL 601
+ K+ +I ++++ E +L +PF+ ++ +F T LC VMEY GG+ L
Sbjct: 182 ILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHL 241
Query: 602 KNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGL 661
+ R Y AE V ALEYLH+ +V+RD+K +NL++ GHIK+TDFGL K G+
Sbjct: 242 SRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGI 301
Query: 662 MSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVG 721
T K CGTPEY+APEV+ YG+ VDWW +G+++YE + G
Sbjct: 302 SDGATM---------------KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCG 346
Query: 722 CVPFFGDTPEELFGQVISDEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTG--SAYEV 779
+PF+ E LF ++ +EI +P L P+A+ L + LL ++P +RLG G A EV
Sbjct: 347 RLPFYNQDHERLFELILMEEIRFP---RTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEV 403
Query: 780 KQHPFFTGLDWTGLLRQK--AEFIPQLESEDDTSYFD 814
+H FF ++W ++++K F PQ+ SE DT YFD
Sbjct: 404 MEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFD 440
>gi|24307971 serine/threonine kinase 38 like [Homo sapiens]
Length = 464
Score = 228 bits (581), Expect = 4e-59
Identities = 123/327 (37%), Positives = 187/327 (57%), Gaps = 24/327 (7%)
Query: 510 EDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAEN 569
+DFE++K+I GA+G V LV+ K T +AMK + K +++ + Q+ ERDIL A+
Sbjct: 88 DDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADG 147
Query: 570 PFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNY 629
+VV MF SF KR+L ++ME++ GGD TLL L + + Y +ETVLA++ +H
Sbjct: 148 AWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQL 207
Query: 630 GIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLY-------------------- 669
G +HRD+KPDNLL+ + GH+KL+DFGL + T Y
Sbjct: 208 GFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKR 267
Query: 670 EGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDT 729
+ K R L GTP+YIAPEV ++ GY K DWW++G+I+YE L+G PF +T
Sbjct: 268 KAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSET 327
Query: 730 PEELFGQVIS--DEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTG 787
P+E + +V++ + +V+P + + A+DL + + R+G E+K HPFF G
Sbjct: 328 PQETYRKVMNWKETLVFPP-EVPISEKAKDLILRFCIDSE-NRIGNSGVEEIKGHPFFEG 385
Query: 788 LDWTGLLRQKAEFIPQLESEDDTSYFD 814
+DW + + A +++S DDTS FD
Sbjct: 386 VDWEHIRERPAAIPIEIKSIDDTSNFD 412
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 228 bits (580), Expect = 5e-59
Identities = 133/354 (37%), Positives = 194/354 (54%), Gaps = 29/354 (8%)
Query: 467 GLTRDPLEEMAQLSSCDSPDTPETDDSIEGHGASLPSKK-TPSEEDFETIKLISNGAYGA 525
GL + EEM S +P + E SL K + +FE +KL+ G +G
Sbjct: 109 GLKKQEEEEMDFRSG-----SPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGK 163
Query: 526 VFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFDTKRHL 585
V LV+ K+T + +AMK + K+ ++ ++++ E +L + +PF+ ++ SF T L
Sbjct: 164 VILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRL 223
Query: 586 CMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHN-YGIVHRDLKPDNLLIT 644
C VMEY GG+ L D R Y AE V AL+YLH+ +V+RDLK +NL++
Sbjct: 224 CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD 283
Query: 645 SMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGK 704
GHIK+TDFGL K G+ T K CGTPEY+APEV+ YG+
Sbjct: 284 KDGHIKITDFGLCKEGIKDGATM---------------KTFCGTPEYLAPEVLEDNDYGR 328
Query: 705 PVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDEALPPDAQDLTSKLLH 764
VDWW +G+++YE + G +PF+ E+LF ++ +EI +P L P+A+ L S LL
Sbjct: 329 AVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP---RTLGPEAKSLLSGLLK 385
Query: 765 QNPLERLGTGS--AYEVKQHPFFTGLDWTGLLRQKAE--FIPQLESEDDTSYFD 814
++P +RLG GS A E+ QH FF G+ W + +K F PQ+ SE DT YFD
Sbjct: 386 KDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFD 439
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 228 bits (580), Expect = 5e-59
Identities = 133/354 (37%), Positives = 194/354 (54%), Gaps = 29/354 (8%)
Query: 467 GLTRDPLEEMAQLSSCDSPDTPETDDSIEGHGASLPSKK-TPSEEDFETIKLISNGAYGA 525
GL + EEM S +P + E SL K + +FE +KL+ G +G
Sbjct: 109 GLKKQEEEEMDFRSG-----SPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGK 163
Query: 526 VFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFDTKRHL 585
V LV+ K+T + +AMK + K+ ++ ++++ E +L + +PF+ ++ SF T L
Sbjct: 164 VILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRL 223
Query: 586 CMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHN-YGIVHRDLKPDNLLIT 644
C VMEY GG+ L D R Y AE V AL+YLH+ +V+RDLK +NL++
Sbjct: 224 CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD 283
Query: 645 SMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGK 704
GHIK+TDFGL K G+ T K CGTPEY+APEV+ YG+
Sbjct: 284 KDGHIKITDFGLCKEGIKDGATM---------------KTFCGTPEYLAPEVLEDNDYGR 328
Query: 705 PVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDEALPPDAQDLTSKLLH 764
VDWW +G+++YE + G +PF+ E+LF ++ +EI +P L P+A+ L S LL
Sbjct: 329 AVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP---RTLGPEAKSLLSGLLK 385
Query: 765 QNPLERLGTGS--AYEVKQHPFFTGLDWTGLLRQKAE--FIPQLESEDDTSYFD 814
++P +RLG GS A E+ QH FF G+ W + +K F PQ+ SE DT YFD
Sbjct: 386 KDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFD 439
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 228 bits (580), Expect = 5e-59
Identities = 133/354 (37%), Positives = 194/354 (54%), Gaps = 29/354 (8%)
Query: 467 GLTRDPLEEMAQLSSCDSPDTPETDDSIEGHGASLPSKK-TPSEEDFETIKLISNGAYGA 525
GL + EEM S +P + E SL K + +FE +KL+ G +G
Sbjct: 109 GLKKQEEEEMDFRSG-----SPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGK 163
Query: 526 VFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFDTKRHL 585
V LV+ K+T + +AMK + K+ ++ ++++ E +L + +PF+ ++ SF T L
Sbjct: 164 VILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRL 223
Query: 586 CMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHN-YGIVHRDLKPDNLLIT 644
C VMEY GG+ L D R Y AE V AL+YLH+ +V+RDLK +NL++
Sbjct: 224 CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD 283
Query: 645 SMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGK 704
GHIK+TDFGL K G+ T K CGTPEY+APEV+ YG+
Sbjct: 284 KDGHIKITDFGLCKEGIKDGATM---------------KTFCGTPEYLAPEVLEDNDYGR 328
Query: 705 PVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDEALPPDAQDLTSKLLH 764
VDWW +G+++YE + G +PF+ E+LF ++ +EI +P L P+A+ L S LL
Sbjct: 329 AVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP---RTLGPEAKSLLSGLLK 385
Query: 765 QNPLERLGTGS--AYEVKQHPFFTGLDWTGLLRQKAE--FIPQLESEDDTSYFD 814
++P +RLG GS A E+ QH FF G+ W + +K F PQ+ SE DT YFD
Sbjct: 386 KDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFD 439
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 225 bits (573), Expect = 3e-58
Identities = 121/321 (37%), Positives = 179/321 (55%), Gaps = 25/321 (7%)
Query: 502 PSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVER 561
P++ T + FE IK + G++G V LV+HK T +AMK ++KQ ++ QI+ E+
Sbjct: 26 PAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEK 85
Query: 562 DILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVL 621
IL PF+V + SF +L MVMEYV GG+ + L+ IG R Y A+ VL
Sbjct: 86 RILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVL 145
Query: 622 ALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFL 681
EYLH+ +++RDLKP+NLLI G+I++TDFG +K + T L
Sbjct: 146 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK-RVKGRTWTL------------- 191
Query: 682 DKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDE 741
CGTPEY+APE+IL +GY K VDWWA+G+++YE G PFF D P +++ +++S +
Sbjct: 192 ----CGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK 247
Query: 742 IVWPEGDEALPPDAQDLTSKLLHQNPLERLGT--GSAYEVKQHPFFTGLDWTGLLRQKAE 799
+ +P D +DL LL + +R G ++K H +F DW + ++K E
Sbjct: 248 VRFP---SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVE 304
Query: 800 --FIPQLESEDDTSYFDTRSE 818
FIP+ + DTS FD E
Sbjct: 305 APFIPKFKGPGDTSNFDDYEE 325
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 225 bits (573), Expect = 3e-58
Identities = 121/321 (37%), Positives = 179/321 (55%), Gaps = 25/321 (7%)
Query: 502 PSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVER 561
P++ T + FE IK + G++G V LV+HK T +AMK ++KQ ++ QI+ E+
Sbjct: 34 PAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEK 93
Query: 562 DILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVL 621
IL PF+V + SF +L MVMEYV GG+ + L+ IG R Y A+ VL
Sbjct: 94 RILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVL 153
Query: 622 ALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFL 681
EYLH+ +++RDLKP+NLLI G+I++TDFG +K + T L
Sbjct: 154 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK-RVKGRTWTL------------- 199
Query: 682 DKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDE 741
CGTPEY+APE+IL +GY K VDWWA+G+++YE G PFF D P +++ +++S +
Sbjct: 200 ----CGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK 255
Query: 742 IVWPEGDEALPPDAQDLTSKLLHQNPLERLGT--GSAYEVKQHPFFTGLDWTGLLRQKAE 799
+ +P D +DL LL + +R G ++K H +F DW + ++K E
Sbjct: 256 VRFP---SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVE 312
Query: 800 --FIPQLESEDDTSYFDTRSE 818
FIP+ + DTS FD E
Sbjct: 313 APFIPKFKGPGDTSNFDDYEE 333
>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
isoform 2 [Homo sapiens]
Length = 351
Score = 224 bits (571), Expect = 6e-58
Identities = 121/321 (37%), Positives = 179/321 (55%), Gaps = 25/321 (7%)
Query: 502 PSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVER 561
P++ EDFE K + G++G V LV+HK+T Q +AMK ++KQ ++ QI+ E+
Sbjct: 34 PTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEK 93
Query: 562 DILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVL 621
IL PF+V + +F +L MVMEYV GG+ + L+ IG R Y A+ VL
Sbjct: 94 RILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVL 153
Query: 622 ALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFL 681
EYLH+ +++RDLKP+NLLI G+I++TDFG +K + T L
Sbjct: 154 TFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK-RVKGRTWTL------------- 199
Query: 682 DKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDE 741
CGTPEY+APE+IL +GY K VDWWA+G+++YE G PFF D P +++ +++S +
Sbjct: 200 ----CGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK 255
Query: 742 IVWPEGDEALPPDAQDLTSKLLHQNPLERLGT--GSAYEVKQHPFFTGLDWTGLLRQKAE 799
+ +P D +DL LL + +R G ++K H +F DW + ++K E
Sbjct: 256 VRFP---SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVE 312
Query: 800 --FIPQLESEDDTSYFDTRSE 818
FIP+ DTS FD E
Sbjct: 313 APFIPKFRGSGDTSNFDDYEE 333
>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
isoform 1 [Homo sapiens]
Length = 398
Score = 224 bits (571), Expect = 6e-58
Identities = 121/321 (37%), Positives = 179/321 (55%), Gaps = 25/321 (7%)
Query: 502 PSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVER 561
P++ EDFE K + G++G V LV+HK+T Q +AMK ++KQ ++ QI+ E+
Sbjct: 81 PTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEK 140
Query: 562 DILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVL 621
IL PF+V + +F +L MVMEYV GG+ + L+ IG R Y A+ VL
Sbjct: 141 RILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVL 200
Query: 622 ALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFL 681
EYLH+ +++RDLKP+NLLI G+I++TDFG +K + T L
Sbjct: 201 TFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK-RVKGRTWTL------------- 246
Query: 682 DKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDE 741
CGTPEY+APE+IL +GY K VDWWA+G+++YE G PFF D P +++ +++S +
Sbjct: 247 ----CGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK 302
Query: 742 IVWPEGDEALPPDAQDLTSKLLHQNPLERLGT--GSAYEVKQHPFFTGLDWTGLLRQKAE 799
+ +P D +DL LL + +R G ++K H +F DW + ++K E
Sbjct: 303 VRFP---SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVE 359
Query: 800 --FIPQLESEDDTSYFDTRSE 818
FIP+ DTS FD E
Sbjct: 360 APFIPKFRGSGDTSNFDDYEE 380
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 221 bits (563), Expect = 5e-57
Identities = 131/366 (35%), Positives = 206/366 (56%), Gaps = 30/366 (8%)
Query: 512 FETIKLISNGAYGAVFLVRH---KSTRQRFAMKKINKQNLILRNQIQQAFV--ERDILTF 566
FE ++++ G YG VF VR + + +AMK + K ++ RN A ER+IL
Sbjct: 67 FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIV-RNAKDTAHTRAERNILES 125
Query: 567 AENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYL 626
++PF+V + +F T L +++E + GG+ T L+ G D Y AE LAL +L
Sbjct: 126 VKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHL 185
Query: 627 HNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVC 686
H+ GI++RDLKP+N++++S GHIKLTDFGL K +++EG + C
Sbjct: 186 HSQGIIYRDLKPENIMLSSQGHIKLTDFGLCK-------ESIHEGAV--------THTFC 230
Query: 687 GTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPE 746
GT EY+APE+++R G+ + VDWW++G ++Y+ L G PF + ++ ++I ++ P
Sbjct: 231 GTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALP- 289
Query: 747 GDEALPPDAQDLTSKLLHQNPLERL--GTGSAYEVKQHPFFTGLDWTGLLRQKAE--FIP 802
L PDA+DL K L +NP +R+ G G A +V++HPFF ++W LL + + F P
Sbjct: 290 --PYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRP 347
Query: 803 QLESEDDTSYFDTRSERYHHMDSEDEEEVSEDGCLEIRQFSSCSPRFNKVYSSMERLSLL 862
L+SE+D S FDTR R +DS D+ +SE F+ +P + + S E S
Sbjct: 348 CLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAP--SVLDSIKEGFSFQ 405
Query: 863 EERRTP 868
+ R+P
Sbjct: 406 PKLRSP 411
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 220 bits (560), Expect = 1e-56
Identities = 134/376 (35%), Positives = 209/376 (55%), Gaps = 32/376 (8%)
Query: 502 PSKKTPSEEDFETIKLISNGAYGAVFLVRH---KSTRQRFAMKKINKQNLILRNQIQQAF 558
P K P E FE ++++ G YG VF VR +T + FAMK + K +I+RN A
Sbjct: 83 PEKIRP--ECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKA-MIVRNAKDTAH 139
Query: 559 V--ERDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYF 616
ER+IL ++PF+V + +F T L +++EY+ GG+ L+ G D Y
Sbjct: 140 TKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYL 199
Query: 617 AETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKD 676
AE +AL +LH GI++RDLKP+N+++ GH+KLTDFGL K ++++G +
Sbjct: 200 AEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCK-------ESIHDGTV--- 249
Query: 677 AREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQ 736
CGT EY+APE+++R G+ + VDWW++G ++Y+ L G PF G+ ++ +
Sbjct: 250 -----THTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDK 304
Query: 737 VISDEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGT--GSAYEVKQHPFFTGLDWTGLL 794
++ ++ P L +A+DL KLL +N RLG G A EV+ HPFF ++W LL
Sbjct: 305 ILKCKLNLP---PYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELL 361
Query: 795 RQKAE--FIPQLESEDDTSYFDTRSERYHHMDSEDEEEVSEDGCLEIRQFSSCSPRFNKV 852
+K E F P L+SE+D S FD++ R +DS D+ +SE F+ +P + +
Sbjct: 362 ARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAP--SVL 419
Query: 853 YSSMERLSLLEERRTP 868
S E+ S + R+P
Sbjct: 420 ESVKEKFSFEPKIRSP 435
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 219 bits (558), Expect = 2e-56
Identities = 119/308 (38%), Positives = 179/308 (58%), Gaps = 23/308 (7%)
Query: 510 EDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFA-E 568
EDF K++ G++G VFL K T Q FA+K + K +++ + ++ VE+ +L+ A E
Sbjct: 378 EDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWE 437
Query: 569 NPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHN 628
+PF+ MFC+F TK +L VMEY+ GGD +++ + Y AE +L L++LH+
Sbjct: 438 HPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHS 497
Query: 629 YGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGT 688
GIV+RDLK DN+L+ GHIK+ DFG+ K ++ DA+ CGT
Sbjct: 498 KGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLG------------DAK---TNTFCGT 542
Query: 689 PEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGD 748
P+YIAPE++L Q Y VDWW+ G++LYE L+G PF G EELF + D +P
Sbjct: 543 PDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRW- 601
Query: 749 EALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAE--FIPQLES 806
L +A+DL KL + P +RLG +++QHP F ++W L R++ + F P+++S
Sbjct: 602 --LEKEAKDLLVKLFVREPEKRLGVRG--DIRQHPLFREINWEELERKEIDPPFRPKVKS 657
Query: 807 EDDTSYFD 814
D S FD
Sbjct: 658 PFDCSNFD 665
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 219 bits (557), Expect = 2e-56
Identities = 123/355 (34%), Positives = 190/355 (53%), Gaps = 24/355 (6%)
Query: 466 LGLTRDPLEEMAQLSSCDSPDTPETDDSIEGHGASLPSKKTPSEEDFETIKLISNGAYGA 525
+GL + ++L S + + S EG+G + S ++FE I+++ G++G
Sbjct: 309 MGLQPGNISPTSKLVSRSTLRRQGKESSKEGNGIGVNSSNRLGIDNFEFIRVLGKGSFGK 368
Query: 526 VFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAEN-PFVVSMFCSFDTKRH 584
V L R K T +A+K + K ++ + ++ E+ IL+ A N PF+ +FC F T
Sbjct: 369 VMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDR 428
Query: 585 LCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLIT 644
L VME+V GGD ++ R Y AE + AL +LH+ GI++RDLK DN+L+
Sbjct: 429 LFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLD 488
Query: 645 SMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGK 704
GH KL DFG+ K G+ + T CGTP+YIAPE++ YG
Sbjct: 489 HEGHCKLADFGMCKEGICNGVTT---------------ATFCGTPDYIAPEILQEMLYGP 533
Query: 705 PVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDEALPPDAQDLTSKLLH 764
VDWWAMG++LYE L G PF + ++LF +++DE+V+P L DA + +
Sbjct: 534 AVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTW---LHEDATGILKSFMT 590
Query: 765 QNPLERLGT---GSAYEVKQHPFFTGLDWTGLLRQKAE--FIPQLESEDDTSYFD 814
+NP RLG+ G + + +HPFF +DW L ++ E F P+++S +D S FD
Sbjct: 591 KNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFD 645
>gi|6005814 serine/threonine kinase 38 [Homo sapiens]
Length = 465
Score = 219 bits (557), Expect = 2e-56
Identities = 122/327 (37%), Positives = 185/327 (56%), Gaps = 24/327 (7%)
Query: 510 EDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAEN 569
EDFE++K+I GA+G V LV+ K T +AMK + K +++ + Q+ ERDIL A++
Sbjct: 87 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADS 146
Query: 570 PFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNY 629
+VV MF SF K +L ++ME++ GGD TLL L + + Y AETVLA++ +H
Sbjct: 147 LWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQL 206
Query: 630 GIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLY-------------------- 669
G +HRD+KPDNLL+ S GH+KL+DFGL + T Y
Sbjct: 207 GFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKR 266
Query: 670 EGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDT 729
+ K R L GTP+YIAPEV ++ GY K DWW++G+I+YE L+G PF +T
Sbjct: 267 KAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSET 326
Query: 730 PEELFGQVIS--DEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTG 787
P+E + +V++ + + +P + + A+DL + + R+G E+K + FF G
Sbjct: 327 PQETYKKVMNWKETLTFPP-EVPISEKAKDLILRFCCEWE-HRIGAPGVEEIKSNSFFEG 384
Query: 788 LDWTGLLRQKAEFIPQLESEDDTSYFD 814
+DW + + A +++S DDTS FD
Sbjct: 385 VDWEHIRERPAAISIEIKSIDDTSNFD 411
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 218 bits (556), Expect = 3e-56
Identities = 125/321 (38%), Positives = 184/321 (57%), Gaps = 33/321 (10%)
Query: 510 EDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAEN 569
ED+E +K+I GA+G V LVRHKSTR+ +AMK ++K +I R+ + ERDI+ FA +
Sbjct: 74 EDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 133
Query: 570 PFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNY 629
P+VV +F +F R+L MVMEY+ GGD L+ N +P R Y AE VLAL+ +H+
Sbjct: 134 PWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWARFYTAEVVLALDAIHSM 192
Query: 630 GIVHRDLKPDNLLITSMGHIKLTDFG----LSKIGLMSLTTNLYEGHIEKDAREFLDKQV 685
G +HRD+KPDN+L+ GH+KL DFG ++K G++ T
Sbjct: 193 GFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDT------------------A 234
Query: 686 CGTPEYIAPEVILRQG----YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVIS-- 739
GTP+YI+PEV+ QG YG+ DWW++G+ LYE LVG PF+ D+ + ++++
Sbjct: 235 VGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHK 294
Query: 740 DEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWT--GLLRQK 797
+ + +P+ D + +A++L L + RLG E+K+H FF W L
Sbjct: 295 NSLTFPD-DNDISKEAKNLICAFLTDREV-RLGRNGVEEIKRHLFFKNDQWAWETLRDTV 352
Query: 798 AEFIPQLESEDDTSYFDTRSE 818
A +P L S+ DTS FD E
Sbjct: 353 APVVPDLSSDIDTSNFDDLEE 373
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 218 bits (555), Expect = 4e-56
Identities = 129/361 (35%), Positives = 201/361 (55%), Gaps = 36/361 (9%)
Query: 463 VSQLGLTRDPLEEMAQLSSCDSP----DTPETDDSIEGHGASLPSKKTPSEEDFETIKLI 518
V+ L + +P+EE + SC + P T EG+ + P++ FE +K++
Sbjct: 28 VNGLKMVDEPMEE-GEADSCHDEGVVKEIPITHHVKEGYEKADPAQ-------FELLKVL 79
Query: 519 SNGAYGAVFLVRHKS---TRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSM 575
G++G VFLVR K+ Q +AMK + K +L +R++++ +ERDIL +PF+V +
Sbjct: 80 GQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTK-MERDILVEVNHPFIVKL 138
Query: 576 FCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRD 635
+F T+ L ++++++ GGD T L + V+ Y AE LAL++LH GIV+RD
Sbjct: 139 HYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRD 198
Query: 636 LKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPE 695
LKP+N+L+ +GHIKLTDFGLSK + EK A F CGT EY+APE
Sbjct: 199 LKPENILLDEIGHIKLTDFGLSKESVDQ----------EKKAYSF-----CGTVEYMAPE 243
Query: 696 VILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDEALPPDA 755
V+ R+G+ + DWW+ G++++E L G +PF G E ++ ++ P + L +A
Sbjct: 244 VVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMP---QFLSAEA 300
Query: 756 QDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAE--FIPQLESEDDTSYF 813
Q L L +NP RLG+ E+K+H FF +DW L +++ + F P DDT F
Sbjct: 301 QSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCF 360
Query: 814 D 814
D
Sbjct: 361 D 361
Score = 105 bits (263), Expect = 3e-22
Identities = 78/291 (26%), Positives = 139/291 (47%), Gaps = 38/291 (13%)
Query: 510 EDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAEN 569
E +E + I G+Y H +T FA+K I+K +I+ ++ + ++
Sbjct: 424 EVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEI------LMRYGQH 477
Query: 570 PFVVSMFCSFDTKRHLCMVMEYVEGGDCATLL---KNIGALPVDMVRLYFAETVLALEYL 626
P ++++ FD R++ +V + ++GG+ + K + ++TV +YL
Sbjct: 478 PNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTV---DYL 534
Query: 627 HNYGIVHRDLKPDNLLI----TSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLD 682
H G+VHRDLKP N+L S I++ DFG +K + L
Sbjct: 535 HCQGVVHRDLKPSNILYMDESASADSIRICDFGFAK---------------QLRGENGLL 579
Query: 683 KQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFF---GDTPEELFGQVIS 739
C T ++APEV+++QGY D W++G++ Y L G PF DTPEE+ ++ +
Sbjct: 580 LTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGN 639
Query: 740 DEIVWPEGD-EALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLD 789
+ G+ + + A+DL S +LH +P +R +A ++ +H + T D
Sbjct: 640 GKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRY---TAEQILKHSWITHRD 687
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 218 bits (554), Expect = 5e-56
Identities = 135/366 (36%), Positives = 201/366 (54%), Gaps = 30/366 (8%)
Query: 458 IPRYIVSQLGLTRDPLEEMAQLSSCDSPDTPETDDSIEGHGASLPSKKTPSEEDFETIKL 517
+PR ++ T P+ DS + + SI H + K PS FE +K+
Sbjct: 19 LPRKQRPRISQTSLPVPGPGSGPQRDSDEGVLKEISITHHVKAGSEKADPSH--FELLKV 76
Query: 518 ISNGAYGAVFLVRHKSTR----QRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVV 573
+ G++G VFLVR K TR +AMK + K L +R++++ +ERDIL +PFVV
Sbjct: 77 LGQGSFGKVFLVR-KVTRPDSGHLYAMKVLKKATLKVRDRVRTK-MERDILADVNHPFVV 134
Query: 574 SMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVH 633
+ +F T+ L ++++++ GGD T L + V+ Y AE L L++LH+ GI++
Sbjct: 135 KLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIY 194
Query: 634 RDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIA 693
RDLKP+N+L+ GHIKLTDFGLSK + EK A F CGT EY+A
Sbjct: 195 RDLKPENILLDEEGHIKLTDFGLSKEAI----------DHEKKAYSF-----CGTVEYMA 239
Query: 694 PEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDEALPP 753
PEV+ RQG+ DWW+ G++++E L G +PF G +E ++ ++ P + L
Sbjct: 240 PEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMP---QFLST 296
Query: 754 DAQDLTSKLLHQNPLERLGTG--SAYEVKQHPFFTGLDWTGLLRQ--KAEFIPQLESEDD 809
+AQ L L +NP RLG+G A E+K+H F++ +DW L R+ K F P + DD
Sbjct: 297 EAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDD 356
Query: 810 TSYFDT 815
T YFDT
Sbjct: 357 TFYFDT 362
Score = 123 bits (309), Expect = 1e-27
Identities = 90/300 (30%), Positives = 146/300 (48%), Gaps = 38/300 (12%)
Query: 501 LPSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVE 560
L K + + + I G+Y HK+T +A+K I+K +I+
Sbjct: 416 LHGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEI---- 471
Query: 561 RDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLL---KNIGALPVDMVRLYFA 617
+L + ++P ++++ +D +H+ +V E + GG+ + K V
Sbjct: 472 --LLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIG 529
Query: 618 ETVLALEYLHNYGIVHRDLKPDNLL-ITSMGH---IKLTDFGLSKIGLMSLTTNLYEGHI 673
+TV EYLH+ G+VHRDLKP N+L + G+ +++ DFG +K
Sbjct: 530 KTV---EYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAK--------------- 571
Query: 674 EKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFF---GDTP 730
+ A L C T ++APEV+ RQGY + D W++GI+LY L G PF DTP
Sbjct: 572 QLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTP 631
Query: 731 EELFGQVISDEIVWPEGD-EALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLD 789
EE+ ++ S + G+ + A+DL SK+LH +P +RL +A +V QHP+ T D
Sbjct: 632 EEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRL---TAKQVLQHPWVTQKD 688
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 218 bits (554), Expect = 5e-56
Identities = 133/372 (35%), Positives = 203/372 (54%), Gaps = 49/372 (13%)
Query: 471 DPLEEMAQLSSCDSPDT---------------PETDD------SIEGHGASLPSKKTPSE 509
DP ++MA S DS + P+T++ +I H K PS+
Sbjct: 8 DPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQ 67
Query: 510 EDFETIKLISNGAYGAVFLVRHKS---TRQRFAMKKINKQNLILRNQIQQAFVERDILTF 566
FE +K++ G++G VFLV+ S RQ +AMK + K L +R++++ +ERDIL
Sbjct: 68 --FELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTK-MERDILVE 124
Query: 567 AENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYL 626
+PF+V + +F T+ L ++++++ GGD T L + V+ Y AE LAL++L
Sbjct: 125 VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHL 184
Query: 627 HNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVC 686
H+ GI++RDLKP+N+L+ GHIKLTDFGLSK + EK A F C
Sbjct: 185 HSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESI----------DHEKKAYSF-----C 229
Query: 687 GTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPE 746
GT EY+APEV+ R+G+ + DWW+ G++++E L G +PF G +E ++ ++ P
Sbjct: 230 GTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMP- 288
Query: 747 GDEALPPDAQDLTSKLLHQNPLERLGTG--SAYEVKQHPFFTGLDWTGLLRQKAE--FIP 802
+ L P+AQ L L +NP RLG G E+K+H FF+ +DW L R++ F P
Sbjct: 289 --QFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKP 346
Query: 803 QLESEDDTSYFD 814
+DT YFD
Sbjct: 347 ATGRPEDTFYFD 358
Score = 116 bits (291), Expect = 2e-25
Identities = 87/291 (29%), Positives = 142/291 (48%), Gaps = 38/291 (13%)
Query: 510 EDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAEN 569
+ +E + I G+Y HK+T FA+K I+K +I+ +L + ++
Sbjct: 420 DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEI------LLRYGQH 473
Query: 570 PFVVSMFCSFDTKRHLCMVMEYVEGGDCATLL---KNIGALPVDMVRLYFAETVLALEYL 626
P ++++ +D +++ +V E ++GG+ + K V +TV EYL
Sbjct: 474 PNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTV---EYL 530
Query: 627 HNYGIVHRDLKPDNLL-ITSMGH---IKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLD 682
H G+VHRDLKP N+L + G+ I++ DFG +K + A L
Sbjct: 531 HAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAK---------------QLRAENGLL 575
Query: 683 KQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFG---DTPEELFGQVIS 739
C T ++APEV+ RQGY D W++G++LY L G PF DTPEE+ ++ S
Sbjct: 576 MTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGS 635
Query: 740 DEIVWPEGD-EALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLD 789
+ G ++ A+DL SK+LH +P +RL +A V +HP+ D
Sbjct: 636 GKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRL---TAALVLRHPWIVHWD 683
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 218 bits (554), Expect = 5e-56
Identities = 127/371 (34%), Positives = 199/371 (53%), Gaps = 41/371 (11%)
Query: 485 PDTPETDDSIEGHGASLPSKKTPSE-----EDFETIKLISNGAYGAVFLVRHKSTRQRFA 539
PDTP++ G L +++ +DF ++ G +G V L +K+T + FA
Sbjct: 626 PDTPQSGLEYSGI-QELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFA 684
Query: 540 MKKINKQNLILRNQIQQAFVERDI---LTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGD 596
+K + K +++ R+++ E+ I + +PF+V++F F TK H+C VMEY GGD
Sbjct: 685 IKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGD 744
Query: 597 CATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGL 656
+ + Y A VL L+YLH + IV+RDLK DNLL+ + G +K+ DFGL
Sbjct: 745 LMMHI-HTDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGL 803
Query: 657 SKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILY 716
K G+ G+ ++ + CGTPE++APEV+ Y + VDWW +G+++Y
Sbjct: 804 CKEGM---------GYGDRTST------FCGTPEFLAPEVLTETSYTRAVDWWGLGVLIY 848
Query: 717 EFLVGCVPFFGDTPEELFGQVISDEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTG-- 774
E LVG PF GD EE+F +++DE+ +P L +A + +LL +NP RLG
Sbjct: 849 EMLVGESPFPGDDEEEVFDSIVNDEVRYP---RFLSTEAISIMRRLLRRNPERRLGASEK 905
Query: 775 SAYEVKQHPFFTGLDWTGLLRQKAE--FIPQLESEDDTSYFDTR---------SERYHHM 823
A +VK+HPFF +DW+ L+ +K + FIP + +D S FD R +
Sbjct: 906 DAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPREPRI 965
Query: 824 DSEDEEEVSED 834
SE+E+E+ D
Sbjct: 966 LSEEEQEMFRD 976
>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
sapiens]
Length = 351
Score = 218 bits (554), Expect = 5e-56
Identities = 115/321 (35%), Positives = 178/321 (55%), Gaps = 25/321 (7%)
Query: 502 PSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVER 561
P++ T S + FE ++ + G++G V LVRH+ T +AMK +NKQ ++ Q++ E+
Sbjct: 34 PAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEK 93
Query: 562 DILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVL 621
IL + PF+V + SF +L +VMEYV GG+ + L+ +G Y A+ VL
Sbjct: 94 RILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVL 153
Query: 622 ALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFL 681
A++YLH+ ++HRDLKP+NLLI G++++TDFG +K + T L
Sbjct: 154 AVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAK-RVKGRTWTL------------- 199
Query: 682 DKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDE 741
CGTPEY+APE+IL +GY K VDWWA+G+++YE VG PF+ D P +++ +++S
Sbjct: 200 ----CGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGR 255
Query: 742 IVWPEGDEALPPDAQDLTSKLLHQNPLERLGT--GSAYEVKQHPFFTGLDWTGLLRQKAE 799
+ +P L D + L LL + +R G ++K H +F W + +K E
Sbjct: 256 VRFP---SKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVE 312
Query: 800 --FIPQLESEDDTSYFDTRSE 818
FIP+ D S FD E
Sbjct: 313 APFIPKYTGPGDASNFDDYEE 333
>gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo
sapiens]
Length = 639
Score = 217 bits (552), Expect = 9e-56
Identities = 131/383 (34%), Positives = 195/383 (50%), Gaps = 37/383 (9%)
Query: 510 EDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAEN 569
+DFE +K+I GA+ V +V+ K T Q +AMK +NK +++ R ++ ERD+L +
Sbjct: 79 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 138
Query: 570 PFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIG-ALPVDMVRLYFAETVLALEYLHN 628
++ + +F + +L +VMEY GGD TLL G +P +M R Y AE V+A++ +H
Sbjct: 139 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 198
Query: 629 YGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGT 688
G VHRD+KPDN+L+ GHI+L DFG + + + R + GT
Sbjct: 199 LGYVHRDIKPDNILLDRCGHIRLADFG-----------SCLKLRADGTVRSLV---AVGT 244
Query: 689 PEYIAPEVILRQG-------YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI--S 739
P+Y++PE++ G YG DWWA+G+ YE G PF+ D+ E +G+++
Sbjct: 245 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYK 304
Query: 740 DEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAE 799
+ + P DE +P +A+D +LL P RLG G A + + HPFF GLDW GL
Sbjct: 305 EHLSLPLVDEGVPEEARDFIQRLLCP-PETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 363
Query: 800 FIPQLESEDDTSYFDTRSERYHHMDSEDEEEVSEDGCLEIRQFSSCS---PRFNKVYSSM 856
F P E DT FD + M S E +S +IR+ + P YS M
Sbjct: 364 FTPDFEGATDTCNFDLVEDGLTAMVSGGGETLS-----DIREGAPLGVHLPFVGYSYSCM 418
Query: 857 ERLSLLEERRTPPPTKRSLSEEK 879
L + P PT L E+
Sbjct: 419 ----ALRDSEVPGPTPMELEAEQ 437
>gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo
sapiens]
Length = 629
Score = 217 bits (552), Expect = 9e-56
Identities = 131/383 (34%), Positives = 195/383 (50%), Gaps = 37/383 (9%)
Query: 510 EDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAEN 569
+DFE +K+I GA+ V +V+ K T Q +AMK +NK +++ R ++ ERD+L +
Sbjct: 69 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 128
Query: 570 PFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIG-ALPVDMVRLYFAETVLALEYLHN 628
++ + +F + +L +VMEY GGD TLL G +P +M R Y AE V+A++ +H
Sbjct: 129 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 188
Query: 629 YGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGT 688
G VHRD+KPDN+L+ GHI+L DFG + + + R + GT
Sbjct: 189 LGYVHRDIKPDNILLDRCGHIRLADFG-----------SCLKLRADGTVRSLV---AVGT 234
Query: 689 PEYIAPEVILRQG-------YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI--S 739
P+Y++PE++ G YG DWWA+G+ YE G PF+ D+ E +G+++
Sbjct: 235 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYK 294
Query: 740 DEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAE 799
+ + P DE +P +A+D +LL P RLG G A + + HPFF GLDW GL
Sbjct: 295 EHLSLPLVDEGVPEEARDFIQRLLCP-PETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 353
Query: 800 FIPQLESEDDTSYFDTRSERYHHMDSEDEEEVSEDGCLEIRQFSSCS---PRFNKVYSSM 856
F P E DT FD + M S E +S +IR+ + P YS M
Sbjct: 354 FTPDFEGATDTCNFDLVEDGLTAMVSGGGETLS-----DIREGAPLGVHLPFVGYSYSCM 408
Query: 857 ERLSLLEERRTPPPTKRSLSEEK 879
L + P PT L E+
Sbjct: 409 ----ALRDSEVPGPTPMELEAEQ 427
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 217 bits (552), Expect = 9e-56
Identities = 136/359 (37%), Positives = 200/359 (55%), Gaps = 37/359 (10%)
Query: 472 PLE-EMAQLSSCDSPDTPETDD------SIEGHGASLPSKKTPSEEDFETIKLISNGAYG 524
PL+ E Q S ++ P D+ SI H + K PS FE +K++ G++G
Sbjct: 17 PLDPENGQTSGEEAGLQPSKDEGVLKEISITHHVKAGSEKADPSH--FELLKVLGQGSFG 74
Query: 525 AVFLVRHKSTR----QRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFD 580
VFLVR K TR +AMK + K L +R++++ +ERDIL +PFVV + +F
Sbjct: 75 KVFLVR-KVTRPDSGHLYAMKVLKKATLKVRDRVRTK-MERDILADVNHPFVVKLHYAFQ 132
Query: 581 TKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDN 640
T+ L ++++++ GGD T L + V+ Y AE L L++LH+ GI++RDLKP+N
Sbjct: 133 TEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPEN 192
Query: 641 LLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQ 700
+L+ GHIKLTDFGLSK + EK A F CGT EY+APEV+ RQ
Sbjct: 193 ILLDEEGHIKLTDFGLSKEAI----------DHEKKAYSF-----CGTVEYMAPEVVNRQ 237
Query: 701 GYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDEALPPDAQDLTS 760
G+ DWW+ G++++E L G +PF G +E ++ ++ P + L +AQ L
Sbjct: 238 GHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMP---QFLSTEAQSLLR 294
Query: 761 KLLHQNPLERLGTG--SAYEVKQHPFFTGLDWTGLLRQ--KAEFIPQLESEDDTSYFDT 815
L +NP RLG+G A E+K+H F++ +DW L R+ K F P + DDT YFDT
Sbjct: 295 ALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDT 353
Score = 123 bits (309), Expect = 1e-27
Identities = 90/300 (30%), Positives = 146/300 (48%), Gaps = 38/300 (12%)
Query: 501 LPSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVE 560
L K + + + I G+Y HK+T +A+K I+K +I+
Sbjct: 407 LHGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEI---- 462
Query: 561 RDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLL---KNIGALPVDMVRLYFA 617
+L + ++P ++++ +D +H+ +V E + GG+ + K V
Sbjct: 463 --LLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIG 520
Query: 618 ETVLALEYLHNYGIVHRDLKPDNLL-ITSMGH---IKLTDFGLSKIGLMSLTTNLYEGHI 673
+TV EYLH+ G+VHRDLKP N+L + G+ +++ DFG +K
Sbjct: 521 KTV---EYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAK--------------- 562
Query: 674 EKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFF---GDTP 730
+ A L C T ++APEV+ RQGY + D W++GI+LY L G PF DTP
Sbjct: 563 QLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTP 622
Query: 731 EELFGQVISDEIVWPEGD-EALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLD 789
EE+ ++ S + G+ + A+DL SK+LH +P +RL +A +V QHP+ T D
Sbjct: 623 EEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRL---TAKQVLQHPWVTQKD 679
>gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo
sapiens]
Length = 625
Score = 215 bits (548), Expect = 3e-55
Identities = 129/380 (33%), Positives = 192/380 (50%), Gaps = 36/380 (9%)
Query: 510 EDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAEN 569
+DFE +K+I GA+ V +V+ K T Q +AMK +NK +++ R ++ ERD+L +
Sbjct: 69 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 128
Query: 570 PFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIG-ALPVDMVRLYFAETVLALEYLHN 628
++ + +F + +L +VMEY GGD TLL G +P +M R Y AE V+A++ +H
Sbjct: 129 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 188
Query: 629 YGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGT 688
G VHRD+KPDN+L+ GHI+L DFG + + + R + GT
Sbjct: 189 LGYVHRDIKPDNILLDRCGHIRLADFG-----------SCLKLRADGTVRSLV---AVGT 234
Query: 689 PEYIAPEVILRQG-------YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI--S 739
P+Y++PE++ G YG DWWA+G+ YE G PF+ D+ E +G+++
Sbjct: 235 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYK 294
Query: 740 DEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAE 799
+ + P DE +P +A+D +LL P RLG G A + + HPFF GLDW GL
Sbjct: 295 EHLSLPLVDEGVPEEARDFIQRLLCP-PETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 353
Query: 800 FIPQLESEDDTSYFDTRSERYHHMDSEDEEEVSEDGCLEIRQFSSCSPRFNKVYSSMERL 859
F P E DT FD + M E ++ E L + P YS M
Sbjct: 354 FTPDFEGATDTCNFDLVEDGLTAM--ETLSDIREGAPLGVH-----LPFVGYSYSCM--- 403
Query: 860 SLLEERRTPPPTKRSLSEEK 879
L + P PT L E+
Sbjct: 404 -ALRDSEVPGPTPMELEAEQ 422
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.129 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,255,613
Number of Sequences: 37866
Number of extensions: 4617424
Number of successful extensions: 30832
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 844
Number of HSP's successfully gapped in prelim test: 1398
Number of HSP's that attempted gapping in prelim test: 20185
Number of HSP's gapped (non-prelim): 8965
length of query: 1798
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1681
effective length of database: 13,817,196
effective search space: 23226706476
effective search space used: 23226706476
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.