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Search of human proteins with 16904383
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
(1537 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 3110 0.0
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 698 0.0
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 698 0.0
gi|45827729 scribble isoform b [Homo sapiens] 387 e-107
gi|45827731 scribble isoform a [Homo sapiens] 387 e-107
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 380 e-105
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 194 4e-49
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 176 2e-43
gi|238908508 leucine-rich repeat and death domain-containing pro... 160 7e-39
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 139 3e-32
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 138 4e-32
gi|21389431 leucine rich repeat containing 39 [Homo sapiens] 131 6e-30
gi|4503743 flightless I homolog [Homo sapiens] 129 3e-29
gi|19923729 leucine rich repeat containing 8 family, member C [H... 118 4e-26
gi|62241040 leucine rich repeat containing 8 family, member A [H... 118 5e-26
gi|187829877 leucine rich repeat containing 8 family, member A [... 118 5e-26
gi|187829871 leucine rich repeat containing 8 family, member A [... 118 5e-26
gi|197333706 leucine rich repeat containing 8 family, member D [... 117 1e-25
gi|34222199 leucine rich repeat containing 8 family, member D [H... 117 1e-25
gi|65301141 PH domain and leucine rich repeat protein phosphatas... 115 4e-25
gi|40217803 leucine rich repeat containing 8 family, member E [H... 114 9e-25
gi|61742786 leucine rich repeat and death domain containing prot... 109 2e-23
gi|61742784 leucine rich repeat and death domain containing prot... 109 2e-23
gi|197333692 leucine rich repeat containing 8 family, member B [... 107 9e-23
gi|21245134 leucine rich repeat containing 8 family, member B [H... 107 9e-23
gi|223005922 leucine rich repeat containing 10-like [Homo sapiens] 106 2e-22
gi|37221175 PH domain and leucine rich repeat protein phosphatas... 105 3e-22
gi|63003903 leucine rich repeat containing 10 [Homo sapiens] 99 3e-20
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 98 5e-20
gi|190014581 leucine rich repeat containing 2 [Homo sapiens] 98 5e-20
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 3110 bits (8062), Expect = 0.0
Identities = 1537/1537 (100%), Positives = 1537/1537 (100%)
Query: 1 MTTKRKIIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEE 60
MTTKRKIIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEE
Sbjct: 1 MTTKRKIIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEE 60
Query: 61 LPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTII 120
LPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTII
Sbjct: 61 LPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTII 120
Query: 121 EASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSM 180
EASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSM
Sbjct: 121 EASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSM 180
Query: 181 HKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKN 240
HKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKN
Sbjct: 181 HKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKN 240
Query: 241 RIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSL 300
RIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSL
Sbjct: 241 RIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSL 300
Query: 301 LEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFL 360
LEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFL
Sbjct: 301 LEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFL 360
Query: 361 PEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQR 420
PEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQR
Sbjct: 361 PEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQR 420
Query: 421 VLTNYMFPQQPRGDEDFQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDENAGKVKDLS 480
VLTNYMFPQQPRGDEDFQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDENAGKVKDLS
Sbjct: 421 VLTNYMFPQQPRGDEDFQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDENAGKVKDLS 480
Query: 481 CQAPWERGQRGITLQPARLSGDCCTPWARCDQQIQDMPVPQNDPQLAWGCISGLQQERSM 540
CQAPWERGQRGITLQPARLSGDCCTPWARCDQQIQDMPVPQNDPQLAWGCISGLQQERSM
Sbjct: 481 CQAPWERGQRGITLQPARLSGDCCTPWARCDQQIQDMPVPQNDPQLAWGCISGLQQERSM 540
Query: 541 CTPLPVAAQSTTLPSLSGRQVEINLKRYPTPYPEDLKNMVKSVQNLVGKPSHGVRVENSN 600
CTPLPVAAQSTTLPSLSGRQVEINLKRYPTPYPEDLKNMVKSVQNLVGKPSHGVRVENSN
Sbjct: 541 CTPLPVAAQSTTLPSLSGRQVEINLKRYPTPYPEDLKNMVKSVQNLVGKPSHGVRVENSN 600
Query: 601 PTANTEQTVKEKYEHKWPVAPKEITVEDSFVHPANEMRIGELHPSLAETPLYPPKLVLLG 660
PTANTEQTVKEKYEHKWPVAPKEITVEDSFVHPANEMRIGELHPSLAETPLYPPKLVLLG
Sbjct: 601 PTANTEQTVKEKYEHKWPVAPKEITVEDSFVHPANEMRIGELHPSLAETPLYPPKLVLLG 660
Query: 661 KDKKESTDESEVDKTHCLNNSVSSGTYSDYSPSQASSGSSNTRVKVGSLQTTAKDAVHNS 720
KDKKESTDESEVDKTHCLNNSVSSGTYSDYSPSQASSGSSNTRVKVGSLQTTAKDAVHNS
Sbjct: 661 KDKKESTDESEVDKTHCLNNSVSSGTYSDYSPSQASSGSSNTRVKVGSLQTTAKDAVHNS 720
Query: 721 LWGNRIAPSFPQPLDSKPLLSQREAVPPGNIPQRPDRLPMSDTFTDNWTDGSHYDNTGFV 780
LWGNRIAPSFPQPLDSKPLLSQREAVPPGNIPQRPDRLPMSDTFTDNWTDGSHYDNTGFV
Sbjct: 721 LWGNRIAPSFPQPLDSKPLLSQREAVPPGNIPQRPDRLPMSDTFTDNWTDGSHYDNTGFV 780
Query: 781 AEETTAENANSNPLLSSKSRSTSSHGRRPLIRQDRIVGVPLELEQSTHRHTPETEVPPSN 840
AEETTAENANSNPLLSSKSRSTSSHGRRPLIRQDRIVGVPLELEQSTHRHTPETEVPPSN
Sbjct: 781 AEETTAENANSNPLLSSKSRSTSSHGRRPLIRQDRIVGVPLELEQSTHRHTPETEVPPSN 840
Query: 841 PWQNWTRTPSPFEDRTAFPSKLETTPTTSPLPERKEHIKESTEIPSPFSPGVPWEYHDSN 900
PWQNWTRTPSPFEDRTAFPSKLETTPTTSPLPERKEHIKESTEIPSPFSPGVPWEYHDSN
Sbjct: 841 PWQNWTRTPSPFEDRTAFPSKLETTPTTSPLPERKEHIKESTEIPSPFSPGVPWEYHDSN 900
Query: 901 PNRSLSNVFSQIHCRPESSKGVISISKSTERLSPLMKDIKSNKFKKSQSIDEIDIGTYKV 960
PNRSLSNVFSQIHCRPESSKGVISISKSTERLSPLMKDIKSNKFKKSQSIDEIDIGTYKV
Sbjct: 901 PNRSLSNVFSQIHCRPESSKGVISISKSTERLSPLMKDIKSNKFKKSQSIDEIDIGTYKV 960
Query: 961 YNIPLENYASGSDHLGSHERPDKMLGPEHGMSSMSRSQSVPMLDDEMLTYGSSKGPQQQK 1020
YNIPLENYASGSDHLGSHERPDKMLGPEHGMSSMSRSQSVPMLDDEMLTYGSSKGPQQQK
Sbjct: 961 YNIPLENYASGSDHLGSHERPDKMLGPEHGMSSMSRSQSVPMLDDEMLTYGSSKGPQQQK 1020
Query: 1021 ASMTKKVYQFDQSFNPQGSVEVKAEKRIPPPFQHNPEYVQQASKNIAKDLISPRAYRGYP 1080
ASMTKKVYQFDQSFNPQGSVEVKAEKRIPPPFQHNPEYVQQASKNIAKDLISPRAYRGYP
Sbjct: 1021 ASMTKKVYQFDQSFNPQGSVEVKAEKRIPPPFQHNPEYVQQASKNIAKDLISPRAYRGYP 1080
Query: 1081 PMEQMFSFSQPSVNEDAVVNAQFASQGARAGFLRRADSLVSATEMAMFRRVNEPHELPPT 1140
PMEQMFSFSQPSVNEDAVVNAQFASQGARAGFLRRADSLVSATEMAMFRRVNEPHELPPT
Sbjct: 1081 PMEQMFSFSQPSVNEDAVVNAQFASQGARAGFLRRADSLVSATEMAMFRRVNEPHELPPT 1140
Query: 1141 DRYGRPPYRGGLDRQSSVTVTESQFLKRNGRYEDEHPSYQEVKAQAGSFPVKNLTQRRPL 1200
DRYGRPPYRGGLDRQSSVTVTESQFLKRNGRYEDEHPSYQEVKAQAGSFPVKNLTQRRPL
Sbjct: 1141 DRYGRPPYRGGLDRQSSVTVTESQFLKRNGRYEDEHPSYQEVKAQAGSFPVKNLTQRRPL 1200
Query: 1201 SARSYSTESYGASQTRPVSARPTMAALLEKIPSDYNLGNYGDKPSDNSDLKTRPTPVKGE 1260
SARSYSTESYGASQTRPVSARPTMAALLEKIPSDYNLGNYGDKPSDNSDLKTRPTPVKGE
Sbjct: 1201 SARSYSTESYGASQTRPVSARPTMAALLEKIPSDYNLGNYGDKPSDNSDLKTRPTPVKGE 1260
Query: 1261 ESCGKMPADWRQQLLRHIEARRLDRNAAYKHNTVNLGMLPYGGISAMHAGRSMTLNLQTK 1320
ESCGKMPADWRQQLLRHIEARRLDRNAAYKHNTVNLGMLPYGGISAMHAGRSMTLNLQTK
Sbjct: 1261 ESCGKMPADWRQQLLRHIEARRLDRNAAYKHNTVNLGMLPYGGISAMHAGRSMTLNLQTK 1320
Query: 1321 SKFDHQELPLQKTPSQQSNILDNGQEDVSPSGQWNPYPLGRRDVPPDTITKKAGSHIQTL 1380
SKFDHQELPLQKTPSQQSNILDNGQEDVSPSGQWNPYPLGRRDVPPDTITKKAGSHIQTL
Sbjct: 1321 SKFDHQELPLQKTPSQQSNILDNGQEDVSPSGQWNPYPLGRRDVPPDTITKKAGSHIQTL 1380
Query: 1381 MGSQSLQHRSREQQPYEGNINKVTIQQFQSPLPIQIPSSQATRGPQPGRCLIQTKGQRSM 1440
MGSQSLQHRSREQQPYEGNINKVTIQQFQSPLPIQIPSSQATRGPQPGRCLIQTKGQRSM
Sbjct: 1381 MGSQSLQHRSREQQPYEGNINKVTIQQFQSPLPIQIPSSQATRGPQPGRCLIQTKGQRSM 1440
Query: 1441 DGYPEQFCVRIEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNLLQPGDKI 1500
DGYPEQFCVRIEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNLLQPGDKI
Sbjct: 1441 DGYPEQFCVRIEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNLLQPGDKI 1500
Query: 1501 LQANGHSFVHMEHEKAVLLLKSFQNTVDLVIQRELTV 1537
LQANGHSFVHMEHEKAVLLLKSFQNTVDLVIQRELTV
Sbjct: 1501 LQANGHSFVHMEHEKAVLLLKSFQNTVDLVIQRELTV 1537
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 698 bits (1801), Expect = 0.0
Identities = 385/708 (54%), Positives = 481/708 (67%), Gaps = 42/708 (5%)
Query: 1 MTTKRKIIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEE 60
MTTKR + RLVPCRC RGEEE ++ LDYSHCSL+QVPKE+F FE+TLEELYLDANQIEE
Sbjct: 1 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 60
Query: 61 LPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTII 120
LPKQLFNCQ+L KLS+PDNDL+ LP +IA+L+NL+ELD+SKNG+QEFPENIK CK LTI+
Sbjct: 61 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 120
Query: 121 EASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSM 180
EASVNPISKLPDGF+QLLNLTQLYLNDAFLEFLPANFGRL KL+ILELREN LK LPK+M
Sbjct: 121 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180
Query: 181 HKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKN 240
++L QLERLDLG+NEF E+PEVL+Q+ L+E WMD N L +PG IG LK L YLD+SKN
Sbjct: 181 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240
Query: 241 RIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSL 300
IE V+ IS CE L+DLLLSSN LQQLP++IG LK +TTLK+D+NQL LP++IG L
Sbjct: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 300
Query: 301 LEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFL 360
+EE DCS NE+E+LPS+IG L +LRT A D N+L +LP EIGS KN+TV+ L SNKLE L
Sbjct: 301 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 360
Query: 361 PEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQR 420
PEE+G MQKL+V+NLSDNRLKNLPFSFTKL++L A+WLSDNQSK LIPLQ E ET++
Sbjct: 361 PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM 420
Query: 421 VLTNYMFPQQPR-GDEDFQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDE---NAGKV 476
VLTNYMFPQQPR D F SD++SFNP+LWEEQR+QR VAFE ++ K++ E G +
Sbjct: 421 VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL 480
Query: 477 KDLSCQAPWERGQRGITLQPA--RLSGDCCTPWARCDQQIQDMPVPQNDPQLAWGCISGL 534
K P E T+Q RL + + D + P D
Sbjct: 481 KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLK------PHED----------- 523
Query: 535 QQERSMCTPLPVAAQSTTLPSLSGRQVEINLKRYPTPYPEDLKNMVKSVQNLVGKPSHGV 594
QQ+ + + + +TT+ S E K M+ + + +P +
Sbjct: 524 QQDINKDVGVKTSESTTTVKS---------------KVDEREKYMIGNSVQKISEPEAEI 568
Query: 595 RVENSNPTANTEQTVKEKYEHKWPVAPKEITVEDSFVHPANEMRIGELHPSLAETPLYPP 654
+ TAN +K K V ++ E + EM++ E+ P L ET + P
Sbjct: 569 SPGSLPVTAN----MKASENLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQP 624
Query: 655 KLVLLGKDKKESTDESEVDKTHCLNNSVSSGTYSDYSPSQASSGSSNT 702
K+V L +KK+ T E++ +NS + + + S S NT
Sbjct: 625 KVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNT 672
Score = 139 bits (351), Expect = 2e-32
Identities = 64/92 (69%), Positives = 82/92 (89%)
Query: 1445 EQFCVRIEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNLLQPGDKILQAN 1504
E+ VR+EK+P LGFSISGG+ G+GNPF+P D GIFVTRVQP+GPAS LLQPGDKI+QAN
Sbjct: 1210 EKIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQAN 1269
Query: 1505 GHSFVHMEHEKAVLLLKSFQNTVDLVIQRELT 1536
G+SF+++EH +AV LLK+FQNTV+L+I RE++
Sbjct: 1270 GYSFINIEHGQAVSLLKTFQNTVELIIVREVS 1301
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 698 bits (1801), Expect = 0.0
Identities = 385/708 (54%), Positives = 481/708 (67%), Gaps = 42/708 (5%)
Query: 1 MTTKRKIIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEE 60
MTTKR + RLVPCRC RGEEE ++ LDYSHCSL+QVPKE+F FE+TLEELYLDANQIEE
Sbjct: 1 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 60
Query: 61 LPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTII 120
LPKQLFNCQ+L KLS+PDNDL+ LP +IA+L+NL+ELD+SKNG+QEFPENIK CK LTI+
Sbjct: 61 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 120
Query: 121 EASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSM 180
EASVNPISKLPDGF+QLLNLTQLYLNDAFLEFLPANFGRL KL+ILELREN LK LPK+M
Sbjct: 121 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180
Query: 181 HKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKN 240
++L QLERLDLG+NEF E+PEVL+Q+ L+E WMD N L +PG IG LK L YLD+SKN
Sbjct: 181 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240
Query: 241 RIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSL 300
IE V+ IS CE L+DLLLSSN LQQLP++IG LK +TTLK+D+NQL LP++IG L
Sbjct: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 300
Query: 301 LEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFL 360
+EE DCS NE+E+LPS+IG L +LRT A D N+L +LP EIGS KN+TV+ L SNKLE L
Sbjct: 301 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 360
Query: 361 PEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQR 420
PEE+G MQKL+V+NLSDNRLKNLPFSFTKL++L A+WLSDNQSK LIPLQ E ET++
Sbjct: 361 PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM 420
Query: 421 VLTNYMFPQQPR-GDEDFQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDE---NAGKV 476
VLTNYMFPQQPR D F SD++SFNP+LWEEQR+QR VAFE ++ K++ E G +
Sbjct: 421 VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL 480
Query: 477 KDLSCQAPWERGQRGITLQPA--RLSGDCCTPWARCDQQIQDMPVPQNDPQLAWGCISGL 534
K P E T+Q RL + + D + P D
Sbjct: 481 KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLK------PHED----------- 523
Query: 535 QQERSMCTPLPVAAQSTTLPSLSGRQVEINLKRYPTPYPEDLKNMVKSVQNLVGKPSHGV 594
QQ+ + + + +TT+ S E K M+ + + +P +
Sbjct: 524 QQDINKDVGVKTSESTTTVKS---------------KVDEREKYMIGNSVQKISEPEAEI 568
Query: 595 RVENSNPTANTEQTVKEKYEHKWPVAPKEITVEDSFVHPANEMRIGELHPSLAETPLYPP 654
+ TAN +K K V ++ E + EM++ E+ P L ET + P
Sbjct: 569 SPGSLPVTAN----MKASENLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQP 624
Query: 655 KLVLLGKDKKESTDESEVDKTHCLNNSVSSGTYSDYSPSQASSGSSNT 702
K+V L +KK+ T E++ +NS + + + S S NT
Sbjct: 625 KVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNT 672
Score = 139 bits (349), Expect = 3e-32
Identities = 63/92 (68%), Positives = 82/92 (89%)
Query: 1445 EQFCVRIEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNLLQPGDKILQAN 1504
++ VR+EK+P LGFSISGG+ G+GNPF+P D GIFVTRVQP+GPAS LLQPGDKI+QAN
Sbjct: 1279 QEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQAN 1338
Query: 1505 GHSFVHMEHEKAVLLLKSFQNTVDLVIQRELT 1536
G+SF+++EH +AV LLK+FQNTV+L+I RE++
Sbjct: 1339 GYSFINIEHGQAVSLLKTFQNTVELIIVREVS 1370
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 387 bits (994), Expect = e-107
Identities = 219/486 (45%), Positives = 302/486 (62%), Gaps = 14/486 (2%)
Query: 15 RCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKL 74
RC R E + D HCSLQ VP+E++ + R+LEEL LDANQ+ ELPK F LRKL
Sbjct: 9 RCNRHVESV----DKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKL 64
Query: 75 SIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGF 134
+ DN++ LP +A+ + L ELD+S+N + E PE+IK CK L I + S NP+S+LPDGF
Sbjct: 65 GLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGF 124
Query: 135 TQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNN 194
TQL +L L LND L+ LP + G L L LELREN LK+LP S+ L +LE+LDLG N
Sbjct: 125 TQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGN 184
Query: 195 EFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEA 254
+ LP+ L + NLRELW+D N L LP +G L+ LV LD+S+NR+E + ++ G
Sbjct: 185 DLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVL 244
Query: 255 LEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESL 314
L DLLLS N+L++LPD IG LK+L+ LKVD N+L + IG+ L E + N L +L
Sbjct: 245 LTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMAL 304
Query: 315 PSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLN 374
P ++G L L L VD N L LP EIG C ++V+SLR N+L LP E+ +L VL+
Sbjct: 305 PRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLD 364
Query: 375 LSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYMFPQQPRGD 434
++ NRL++LPF+ T L L ALWL++NQ++ ++ QTE T ++VLT Y+ PQQP
Sbjct: 365 VAGNRLQSLPFALTHL-NLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQPPLS 423
Query: 435 EDFQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDENAGKVKDLSCQAPWERG-QRGIT 493
+ S + T W + R++V +F + DE+A + A +RG QR T
Sbjct: 424 LEDAGQQGSLSET-WSDAPPSRVSV-IQFLEAPIGDEDAEEA------AAEKRGLQRRAT 475
Query: 494 LQPARL 499
P+ L
Sbjct: 476 PHPSEL 481
Score = 60.1 bits (144), Expect = 2e-08
Identities = 35/86 (40%), Positives = 54/86 (62%), Gaps = 5/86 (5%)
Query: 1451 IEKNPG--LGFSISGGISGQ-GNPFKPSDKGIFVTRVQPDGPA--SNLLQPGDKILQANG 1505
I+K PG LG SI GG G GNP P+D+GIF+++V P G A L+ G ++L+ N
Sbjct: 1103 IQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQ 1162
Query: 1506 HSFVHMEHEKAVLLLKSFQNTVDLVI 1531
S + + H +AV LL+S +T+ +++
Sbjct: 1163 QSLLGLTHGEAVQLLRSVGDTLTVLV 1188
Score = 59.7 bits (143), Expect = 2e-08
Identities = 33/81 (40%), Positives = 47/81 (58%), Gaps = 4/81 (4%)
Query: 1456 GLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPA--SNLLQPGDKILQANGHSFVHMEH 1513
GLGFSI+GG P++ D GIFV+R+ G A + LQ GD++L NG H
Sbjct: 871 GLGFSIAGGKGS--TPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARH 928
Query: 1514 EKAVLLLKSFQNTVDLVIQRE 1534
+ AV LL + T+ L+++RE
Sbjct: 929 DHAVSLLTAASPTIALLLERE 949
Score = 59.3 bits (142), Expect = 3e-08
Identities = 33/88 (37%), Positives = 51/88 (57%), Gaps = 3/88 (3%)
Query: 1451 IEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNL-LQPGDKILQANGHSFV 1509
+ + GLG SI+GG P+K D+GIF++RV +GPA+ ++ GDK+L+ NG +
Sbjct: 732 LRQTGGLGISIAGGKGS--TPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQ 789
Query: 1510 HMEHEKAVLLLKSFQNTVDLVIQRELTV 1537
EH +AV L+ V + + RE V
Sbjct: 790 GAEHHEAVEALRGAGTAVQMRVWRERMV 817
Score = 47.0 bits (110), Expect = 1e-04
Identities = 29/88 (32%), Positives = 48/88 (54%), Gaps = 2/88 (2%)
Query: 1449 VRIEKNPG-LGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNL-LQPGDKILQANGH 1506
+R+ + G LG SI GG +PF + G+F+++V P G A+ L+ GD+IL NG
Sbjct: 1005 IRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQ 1064
Query: 1507 SFVHMEHEKAVLLLKSFQNTVDLVIQRE 1534
H++AV L + L+++R+
Sbjct: 1065 DVRDATHQEAVSALLRPCLELSLLVRRD 1092
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 387 bits (994), Expect = e-107
Identities = 219/486 (45%), Positives = 302/486 (62%), Gaps = 14/486 (2%)
Query: 15 RCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKL 74
RC R E + D HCSLQ VP+E++ + R+LEEL LDANQ+ ELPK F LRKL
Sbjct: 9 RCNRHVESV----DKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKL 64
Query: 75 SIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGF 134
+ DN++ LP +A+ + L ELD+S+N + E PE+IK CK L I + S NP+S+LPDGF
Sbjct: 65 GLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGF 124
Query: 135 TQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNN 194
TQL +L L LND L+ LP + G L L LELREN LK+LP S+ L +LE+LDLG N
Sbjct: 125 TQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGN 184
Query: 195 EFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEA 254
+ LP+ L + NLRELW+D N L LP +G L+ LV LD+S+NR+E + ++ G
Sbjct: 185 DLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVL 244
Query: 255 LEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESL 314
L DLLLS N+L++LPD IG LK+L+ LKVD N+L + IG+ L E + N L +L
Sbjct: 245 LTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMAL 304
Query: 315 PSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLN 374
P ++G L L L VD N L LP EIG C ++V+SLR N+L LP E+ +L VL+
Sbjct: 305 PRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLD 364
Query: 375 LSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYMFPQQPRGD 434
++ NRL++LPF+ T L L ALWL++NQ++ ++ QTE T ++VLT Y+ PQQP
Sbjct: 365 VAGNRLQSLPFALTHL-NLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQPPLS 423
Query: 435 EDFQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDENAGKVKDLSCQAPWERG-QRGIT 493
+ S + T W + R++V +F + DE+A + A +RG QR T
Sbjct: 424 LEDAGQQGSLSET-WSDAPPSRVSV-IQFLEAPIGDEDAEEA------AAEKRGLQRRAT 475
Query: 494 LQPARL 499
P+ L
Sbjct: 476 PHPSEL 481
Score = 60.1 bits (144), Expect = 2e-08
Identities = 35/86 (40%), Positives = 54/86 (62%), Gaps = 5/86 (5%)
Query: 1451 IEKNPG--LGFSISGGISGQ-GNPFKPSDKGIFVTRVQPDGPA--SNLLQPGDKILQANG 1505
I+K PG LG SI GG G GNP P+D+GIF+++V P G A L+ G ++L+ N
Sbjct: 1103 IQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQ 1162
Query: 1506 HSFVHMEHEKAVLLLKSFQNTVDLVI 1531
S + + H +AV LL+S +T+ +++
Sbjct: 1163 QSLLGLTHGEAVQLLRSVGDTLTVLV 1188
Score = 59.7 bits (143), Expect = 2e-08
Identities = 33/81 (40%), Positives = 47/81 (58%), Gaps = 4/81 (4%)
Query: 1456 GLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPA--SNLLQPGDKILQANGHSFVHMEH 1513
GLGFSI+GG P++ D GIFV+R+ G A + LQ GD++L NG H
Sbjct: 871 GLGFSIAGGKGS--TPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARH 928
Query: 1514 EKAVLLLKSFQNTVDLVIQRE 1534
+ AV LL + T+ L+++RE
Sbjct: 929 DHAVSLLTAASPTIALLLERE 949
Score = 59.3 bits (142), Expect = 3e-08
Identities = 33/88 (37%), Positives = 51/88 (57%), Gaps = 3/88 (3%)
Query: 1451 IEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNL-LQPGDKILQANGHSFV 1509
+ + GLG SI+GG P+K D+GIF++RV +GPA+ ++ GDK+L+ NG +
Sbjct: 732 LRQTGGLGISIAGGKGS--TPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQ 789
Query: 1510 HMEHEKAVLLLKSFQNTVDLVIQRELTV 1537
EH +AV L+ V + + RE V
Sbjct: 790 GAEHHEAVEALRGAGTAVQMRVWRERMV 817
Score = 47.0 bits (110), Expect = 1e-04
Identities = 29/88 (32%), Positives = 48/88 (54%), Gaps = 2/88 (2%)
Query: 1449 VRIEKNPG-LGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNL-LQPGDKILQANGH 1506
+R+ + G LG SI GG +PF + G+F+++V P G A+ L+ GD+IL NG
Sbjct: 1005 IRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQ 1064
Query: 1507 SFVHMEHEKAVLLLKSFQNTVDLVIQRE 1534
H++AV L + L+++R+
Sbjct: 1065 DVRDATHQEAVSALLRPCLELSLLVRRD 1092
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 380 bits (976), Expect = e-105
Identities = 207/467 (44%), Positives = 293/467 (62%), Gaps = 14/467 (2%)
Query: 15 RCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKL 74
RC R E I D HCSL VP+E++ + R+LEEL LDANQ+ ELP+Q F LRKL
Sbjct: 9 RCNRHVESI----DKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKL 64
Query: 75 SIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGF 134
+ DN++ LP IA+ + L ELD+S+N + E PE+I CK L + + S NP+++LP+ F
Sbjct: 65 GLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESF 124
Query: 135 TQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNN 194
+L NLT L +ND L+ LP N G L L LELREN L LP S+ +L +LE LDLGNN
Sbjct: 125 PELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNN 184
Query: 195 EFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEA 254
E LPE + + +L++LW+D N L LP IG LK L+ LD+S+NR+E + +ISG +
Sbjct: 185 EIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTS 244
Query: 255 LEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESL 314
L DL++S N+L+ +PD IG LKKL+ LKVD N+LT LP +G L E + N+L +L
Sbjct: 245 LTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTL 304
Query: 315 PSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLN 374
P +IG L L L D N L LP+EIG C ++TV +R N+L +P E+ Q +L VL+
Sbjct: 305 PKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLD 364
Query: 375 LSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYMFPQ---QP 431
++ NRL +LP S T LK L ALWLSDNQS+ L+ QT+ T +++LT + PQ +P
Sbjct: 365 VAGNRLLHLPLSLTALK-LKALWLSDNQSQPLLTFQTDTDYTTGEKILTCVLLPQLPSEP 423
Query: 432 RGDED------FQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDEN 472
E+ ++ + + W E+ R++ ED+K++++N
Sbjct: 424 TCQENLPRCGALENLVNDVSDEAWNERAVNRVSAIRFVEDEKDEEDN 470
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 194 bits (494), Expect = 4e-49
Identities = 126/377 (33%), Positives = 198/377 (52%), Gaps = 5/377 (1%)
Query: 24 ISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSN 83
+ +LD H L+++P V+ + +L LYL N+I + K + N L LSI +N +
Sbjct: 171 LRMLDLRHNKLREIPSVVYRLD-SLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQ 229
Query: 84 LPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQL 143
LP I L NL LD++ N ++ P+ I C +T ++ N + LPD L +L++L
Sbjct: 230 LPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRL 289
Query: 144 YLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSM-HKLAQLERLDLGNNEFGELPEV 202
L L +P + + L L L N++ TLP+S+ L +L L L N F P
Sbjct: 290 GLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVG 349
Query: 203 -LDQIQNLRELWMDNNALQVLP-GSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLL 260
Q + L M++N + +P G + K+L L+M N++ ++ +D ++ +L L
Sbjct: 350 GPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNL 409
Query: 261 SSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGY 320
++N L ++P+ + L L L + +N L LP+ +GNL L E D N+LESLP+ I Y
Sbjct: 410 ATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAY 469
Query: 321 LHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDN-R 379
L L+ L + N L LPR IG N+T + L N L LPEEIG ++ L L L+DN
Sbjct: 470 LKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPN 529
Query: 380 LKNLPFSFTKLKELAAL 396
L +LPF +L+ +
Sbjct: 530 LHSLPFELALCSKLSIM 546
Score = 168 bits (425), Expect = 4e-41
Identities = 114/406 (28%), Positives = 183/406 (45%), Gaps = 49/406 (12%)
Query: 45 ERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGV 104
E L L I LP + L +L + N L +LP + LVNL L +S+N +
Sbjct: 99 EENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSL 158
Query: 105 QEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLR 164
P+++ K L +++ N + ++P +L +LT LYL + + + L KL
Sbjct: 159 TSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLS 218
Query: 165 ILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPG 224
+L +REN +K LP + +L L LD+ +N+ LP+ + + L + +N L LP
Sbjct: 219 MLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPD 278
Query: 225 SIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSI------------ 272
+IG L L L + NR+ + ++ C ALE+L L +N + LP+S+
Sbjct: 279 TIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTL 338
Query: 273 -------------------------------------GLLKKLTTLKVDDNQLTMLPNTI 295
K L+ L + DNQLT LP
Sbjct: 339 ARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDF 398
Query: 296 GNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSN 355
G + + E + + N+L +P + L SL L + N L +LP +G+ + + + L N
Sbjct: 399 GTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEEN 458
Query: 356 KLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDN 401
KLE LP EI ++ L+ L L++N+L LP L L L L +N
Sbjct: 459 KLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGEN 504
Score = 150 bits (379), Expect = 9e-36
Identities = 113/390 (28%), Positives = 183/390 (46%), Gaps = 50/390 (12%)
Query: 93 NLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEF 152
N LD+SK + P +IK LT + N + LP L+NL L L++ L
Sbjct: 101 NSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTS 160
Query: 153 LPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLREL 212
LP + L KLR+L+LR N L+ +P +++L L L L N + + + + L L
Sbjct: 161 LPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSML 220
Query: 213 WMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSI 272
+ N ++ LP IG+L L+ LD++ N++E + +I C + +L L N L LPD+I
Sbjct: 221 SIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTI 280
Query: 273 GLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLP----------------- 315
G L L+ L + N+L+ +P ++ S LEE + N + +LP
Sbjct: 281 GNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLAR 340
Query: 316 --------------STIGYLHS------------------LRTLAVDENFLPELPREIGS 343
STI L+ L L + +N L LP + G+
Sbjct: 341 NCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGT 400
Query: 344 CKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQS 403
++ ++L +N+L +PE++ + L VL LS+N LK LP L++L L L +N+
Sbjct: 401 WTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKL 460
Query: 404 KALIPLQTEAHPETKQRVLTNYMFPQQPRG 433
++L P + + ++ VLTN PRG
Sbjct: 461 ESL-PNEIAYLKDLQKLVLTNNQLTTLPRG 489
Score = 35.4 bits (80), Expect = 0.43
Identities = 23/58 (39%), Positives = 33/58 (56%), Gaps = 2/58 (3%)
Query: 34 LQQVPKEVFNFERTLEELYLDAN-QIEELPKQLFNCQALRKLSIPDNDLSNLPTTIAS 90
L +P+E+ E LEELYL+ N + LP +L C L +SI + LS+LP I +
Sbjct: 506 LTHLPEEIGTLEN-LEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVA 562
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 176 bits (446), Expect = 2e-43
Identities = 119/379 (31%), Positives = 187/379 (49%), Gaps = 4/379 (1%)
Query: 27 LDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLF-NCQALRKLSIPDNDLSNLP 85
LD S+ + V +F L EL L ++E+P +F N L L + N L LP
Sbjct: 99 LDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLP 158
Query: 86 TTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYL 145
I + L+E+ + +N + FP+ + L II+ N I +P+ L L + Y+
Sbjct: 159 KEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYM 218
Query: 146 NDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQ 205
L LPA+ + +L +L+L N L ++PKS +L ++ + L N ++P ++ +
Sbjct: 219 ASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICR 278
Query: 206 IQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNML 265
+L L++ N L L GS L L +LD+S+N + + I + LE L L N +
Sbjct: 279 WTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKI 338
Query: 266 QQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNE---LESLPSTIGYLH 322
QLP +G L KL L + N+ P + +L+ LE+ ++ L +P I L
Sbjct: 339 GQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQ 398
Query: 323 SLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKN 382
SL+ L ++ N L LP +GS N+ V+ R N L+ LP+ I Q Q L+ L L DN L +
Sbjct: 399 SLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTH 458
Query: 383 LPFSFTKLKELAALWLSDN 401
LP + L L L L DN
Sbjct: 459 LPENLDSLVNLKVLTLMDN 477
Score = 158 bits (399), Expect = 4e-38
Identities = 114/377 (30%), Positives = 182/377 (48%), Gaps = 24/377 (6%)
Query: 27 LDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPT 86
+D S+ SL +P E+F F LEE++L+ NQIEE+P+++ + +R L + N+L +L
Sbjct: 30 IDASNQSLTAIPLEIFTFTE-LEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCP 88
Query: 87 TIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLN 146
+ L +L+ LD+S N I +S+ +S F L +LY
Sbjct: 89 ALGLLSSLESLDLSYN---------------PIFSSSLVVVS-----FLHALRELRLYQT 128
Query: 147 DAFLEFLPAN-FGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQ 205
D L+ +P F L L +L L NHLK LPK + +L + L N+F P+ L
Sbjct: 129 D--LKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCV 186
Query: 206 IQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNML 265
+ L + +D N + +P IG L L M+ N + + + C L L LS N+L
Sbjct: 187 LYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLL 246
Query: 266 QQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLR 325
+P S L+K+T + + N+L +P I + L L L + L +LR
Sbjct: 247 HSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLR 306
Query: 326 TLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPF 385
L + +N L P +I + KN+ V+ L NK+ LP E+G + KL++L L+ N + P
Sbjct: 307 FLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPE 366
Query: 386 SFTKLKELAALWLSDNQ 402
L L L++ +Q
Sbjct: 367 EVLSLASLEKLYIGQDQ 383
Score = 158 bits (399), Expect = 4e-38
Identities = 101/354 (28%), Positives = 176/354 (49%), Gaps = 5/354 (1%)
Query: 34 LQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVN 93
L+ +PKE+ N + L E+YL NQ E P++L L + + +N + +P I L
Sbjct: 154 LKCLPKEIVN-QTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTG 212
Query: 94 LKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFL 153
L++ ++ N + P ++ C L++++ S N + +P F +L +T++ L+ LE +
Sbjct: 213 LQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKV 272
Query: 154 PANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELW 213
P R L +L L L L S L L LDL N P + ++NL L
Sbjct: 273 PRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLG 332
Query: 214 MDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNM---LQQLPD 270
+D+N + LP +G L L L ++ N + ++ +LE L + + L +P+
Sbjct: 333 LDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPE 392
Query: 271 SIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVD 330
I L+ L L +++N L LP ++G++ LE DC N L+ LP I +L+ L ++
Sbjct: 393 HIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLE 452
Query: 331 ENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEI-GQMQKLRVLNLSDNRLKNL 383
+N L LP + S N+ V++L N +E P+E+ + + L +NR +N+
Sbjct: 453 DNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLKENRNRNI 506
Score = 122 bits (307), Expect = 2e-27
Identities = 88/285 (30%), Positives = 144/285 (50%), Gaps = 32/285 (11%)
Query: 14 CRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRK 73
C+C + +SVLD SH L +PK F R + E+ L N++E++P+ + +L
Sbjct: 231 CQCSQ-----LSVLDLSHNLLHSIPKS-FAELRKMTEIGLSGNRLEKVPRLICRWTSLHL 284
Query: 74 LSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDG 133
L + + L L + LVNL+ LD+S+N + P I K
Sbjct: 285 LYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALK------------------ 326
Query: 134 FTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGN 193
NL L L+D + LP+ G L KL+IL L N + P+ + LA LE+L +G
Sbjct: 327 -----NLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQ 381
Query: 194 NEFGEL---PEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDIS 250
++ +L PE + ++Q+L+EL+++NN L+ LP S+G + L LD N ++ + I
Sbjct: 382 DQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAIC 441
Query: 251 GCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTI 295
+AL++L L N+L LP+++ L L L + DN + P +
Sbjct: 442 QAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEV 486
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 160 bits (406), Expect = 7e-39
Identities = 101/355 (28%), Positives = 176/355 (49%), Gaps = 23/355 (6%)
Query: 48 LEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEF 107
LE L L N + LP ++ LR L++ N +S++P I+ L N+++L N ++ F
Sbjct: 190 LEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENF 249
Query: 108 PENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILE 167
P +++C L I+ N + +PD LP+ L LR+L
Sbjct: 250 PSDLECLGNLEILSLGKNKLRHIPD-------------------TLPS----LKTLRVLN 286
Query: 168 LRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIG 227
L N L T PK++ L +L LDL N LP+ + +++NL L MD+N L L I
Sbjct: 287 LEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIF 346
Query: 228 KLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQ 287
+L + L ++ N++E + I L L+L N+L+ +P+ I L L + DN+
Sbjct: 347 QLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNK 406
Query: 288 LTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNV 347
LT LP I L+ L + + N + + I +L+++ +L N + ++P EI +C+ +
Sbjct: 407 LTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKI 466
Query: 348 TVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQ 402
+ L NK+ + P + + L L+++ N + +P + K+L L LS+N+
Sbjct: 467 IKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENK 521
Score = 159 bits (403), Expect = 2e-38
Identities = 108/363 (29%), Positives = 178/363 (49%), Gaps = 4/363 (1%)
Query: 34 LQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVN 93
L+ +P+++ + LE L L N++ ELPK + LRKL + N++ + I+ L N
Sbjct: 384 LKNIPEKI-SCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNN 442
Query: 94 LKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFL 153
+ L+ S N + + P IK C+ + IE S N I P G L +L L +N ++ +
Sbjct: 443 ICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEI 502
Query: 154 PANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELW 213
P + +L LEL EN L + L L+ LDLG N+ ++P + + +L L
Sbjct: 503 PVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLI 562
Query: 214 MDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIG 273
+ N + P + L+ L LD+S+N+++ + DI + ++ L SSN P +
Sbjct: 563 LCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELC 622
Query: 274 LLKKLTTLKVDD---NQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVD 330
L+ L L + +LT LP + N++ L+E D S N + +P IG L +L +L
Sbjct: 623 QLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAY 682
Query: 331 ENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKL 390
N + LP + S ++ ++L N L LP I + L+ +N DN L P K
Sbjct: 683 NNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKG 742
Query: 391 KEL 393
K+L
Sbjct: 743 KQL 745
Score = 155 bits (393), Expect = 2e-37
Identities = 114/402 (28%), Positives = 192/402 (47%), Gaps = 24/402 (5%)
Query: 24 ISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSN 83
+ +L+ SH + +PKE+ + +L+ N IE P L L LS+ N L +
Sbjct: 213 LRILNVSHNHISHIPKEISQLGN-IRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRH 271
Query: 84 LPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQL 143
+P T+ SL L+ L++ N + FP+ + L ++ + N IS LP +L NL L
Sbjct: 272 IPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETL 331
Query: 144 YLNDAFLEFLPANFGRLVK-----------------------LRILELRENHLKTLPKSM 180
++ L FL +L+K LRIL L +N LK +P+ +
Sbjct: 332 LMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKI 391
Query: 181 HKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKN 240
A LE L L +N+ ELP+ + ++ NLR+L ++ N + + I L + L+ S N
Sbjct: 392 SCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGN 451
Query: 241 RIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSL 300
I V ++I C+ + + LS N + P + L L L V+ N ++ +P I
Sbjct: 452 IITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQ 511
Query: 301 LEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFL 360
L + S N+L L +L+ L + +N + ++P I + ++ V+ L NK E
Sbjct: 512 LLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETF 571
Query: 361 PEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQ 402
P E+ ++ L+VL+LS+N+L+ + LK + L S NQ
Sbjct: 572 PRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQ 613
Score = 135 bits (341), Expect = 2e-31
Identities = 94/367 (25%), Positives = 186/367 (50%), Gaps = 7/367 (1%)
Query: 51 LYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPEN 110
L N I ++P ++ NCQ + K+ + N + P + +L +L L ++ N + E P +
Sbjct: 446 LEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVD 505
Query: 111 IKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRE 170
I K L +E S N + + F L+NL L L ++ +PA+ ++ L +L L
Sbjct: 506 ISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCC 565
Query: 171 NHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLK 230
N +T P+ + L L+ LDL N+ ++ + ++ +++L +N P + +L+
Sbjct: 566 NKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQ 625
Query: 231 MLVYLDMSK---NRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQ 287
L L++S+ ++ + ++S L++L +S+N ++++P +IG L+ L +L +NQ
Sbjct: 626 SLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQ 685
Query: 288 LTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNV 347
++ LP ++ +L+ L++ + S N L +LPS I + SL+ + D+N L P EI K +
Sbjct: 686 ISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQL 745
Query: 348 TVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALI 407
++ + + E+I + ++ + N + F F K A +D +K+ +
Sbjct: 746 YTIARYLQRADERDEKILE----KIFKIVANNITETNFEFLCQKLNLANSETDMPTKSTV 801
Query: 408 PLQTEAH 414
L AH
Sbjct: 802 SLSERAH 808
Score = 102 bits (255), Expect = 2e-21
Identities = 68/240 (28%), Positives = 112/240 (46%), Gaps = 1/240 (0%)
Query: 166 LELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEV-LDQIQNLRELWMDNNALQVLPG 224
+ L L+ PK + K+ ++ L L N+ + L L + N L LP
Sbjct: 146 VNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPS 205
Query: 225 SIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVD 284
I L L L++S N I + +IS + L +N ++ P + L L L +
Sbjct: 206 EIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLG 265
Query: 285 DNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSC 344
N+L +P+T+ +L L + N+L + P + +L L +L + N + LP+EI
Sbjct: 266 KNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIREL 325
Query: 345 KNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSK 404
KN+ + + NKL FL EI Q+ K++ L L+DN+L+ + +EL L L N K
Sbjct: 326 KNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLK 385
Score = 84.7 bits (208), Expect = 6e-16
Identities = 71/248 (28%), Positives = 112/248 (45%), Gaps = 32/248 (12%)
Query: 191 LGNNEFGEL-PEVLDQIQNLRELWMDN-------NALQVLPGSIGKLKMLVYLDMSKNRI 242
L + GE+ P+V ++ Q L DN LQ P I K+K + YL + KN+I
Sbjct: 117 LSHETVGEVSPQVSEENQKQLGLGADNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQI 176
Query: 243 ETVDMDISG-CEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLL 301
+T SG LE L L N L LP I LL L L V N ++ +P I L +
Sbjct: 177 KTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNI 236
Query: 302 EEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKL---- 357
+ N +E+ PS + L +L L++ +N L +P + S K + V++L N+L
Sbjct: 237 RQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFP 296
Query: 358 -------------------EFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWL 398
LP+EI +++ L L + N+L L +L ++ L L
Sbjct: 297 KALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQL 356
Query: 399 SDNQSKAL 406
+DN+ + +
Sbjct: 357 ADNKLEVI 364
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 139 bits (349), Expect = 3e-32
Identities = 117/415 (28%), Positives = 192/415 (46%), Gaps = 54/415 (13%)
Query: 37 VPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASL----V 92
VP+ + R +L L + E+P+ C + IP+ NL
Sbjct: 27 VPQGLLKAARKSGQLNLSGRNLSEVPQ----CVWRINVDIPEEANQNLSFGATERWWEQT 82
Query: 93 NLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEF 152
+L +L IS N +Q ++++ LT+++ N ++ LP +L NL +L ++ L+
Sbjct: 83 DLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKI 142
Query: 153 LPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLREL 212
LP L L+ L L+ N L + + +L+ LE LDL NN +P + +L L
Sbjct: 143 LPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRL 202
Query: 213 WMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPD-- 270
+ +N L+ LP I ++K L +LD + N +ET+ +++G E+LE L L N L+ LP+
Sbjct: 203 NLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEFP 262
Query: 271 SIGLLKKL---------------------TTLKVDDNQLTMLPNTIGNLSLLEEFDCSCN 309
S LLK+L L + DN+L +P+ I L LE D S N
Sbjct: 263 SCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNN 322
Query: 310 ELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLE----------- 358
++ SLP ++G LH L+ LA++ N L + REI S V+ +K++
Sbjct: 323 DISSLPYSLGNLH-LKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESAT 381
Query: 359 ----FLPEE----IGQMQKLRVLNLSDNRLKNLP---FSFTKLKELAALWLSDNQ 402
LP E I + L++L+ SD + +P F K + ++ S NQ
Sbjct: 382 ETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQ 436
Score = 130 bits (327), Expect = 1e-29
Identities = 113/419 (26%), Positives = 199/419 (47%), Gaps = 39/419 (9%)
Query: 20 EEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDN 79
E E + L+ SH L+ +P+E+ N R L+ LYL N++ + + L L + +N
Sbjct: 126 ELENLQKLNVSHNKLKILPEEITNL-RNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNN 184
Query: 80 DLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLN 139
L+ +P + +SL +L L++S N ++ P I K L ++ + N + +P + +
Sbjct: 185 HLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMES 244
Query: 140 LTQLYLNDAFLEFLPA-----------------------NFGRLVKLRILELRENHLKTL 176
L LYL L FLP + L + +L+LR+N LK++
Sbjct: 245 LELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSV 304
Query: 177 PKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSI---GKLKMLV 233
P + L LERLDL NN+ LP L + +L+ L ++ N L+ + I G ++L
Sbjct: 305 PDEIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLK 363
Query: 234 YLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPN 293
YL SK + + S E L S + +I + L L D Q T++P+
Sbjct: 364 YL-RSKIKDDGPSQSESATETAMTLPSESRV------NIHAIITLKILDYSDKQATLIPD 416
Query: 294 TIGNL---SLLEEFDCSCNELESLPSTIGYLHSLRT-LAVDENFLPELPREIGSCKNVTV 349
+ + +++ + S N+L +P + L + + + + N L + E+ + +T
Sbjct: 417 EVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTF 476
Query: 350 MSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIP 408
+ LR+N L LPEE+ + +L+ +NLS NR K LP ++ L + +S+NQ ++ P
Sbjct: 477 LDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDP 535
Score = 101 bits (251), Expect = 6e-21
Identities = 99/395 (25%), Positives = 186/395 (47%), Gaps = 29/395 (7%)
Query: 27 LDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPT 86
L+ S L+ +P E+ +R L+ L ++N +E +P +L ++L L + N L LP
Sbjct: 202 LNLSSNELKSLPAEINRMKR-LKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE 260
Query: 87 TIASLVNLKELDISKNGVQEFP-ENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYL 145
S LKEL + +N ++ E++K + +++ N + +PD L +L +L L
Sbjct: 261 -FPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDL 319
Query: 146 NDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERL--------DLGNNEFG 197
++ + LP + G L L+ L L N L+T+ + + E L D G ++
Sbjct: 320 SNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSE 378
Query: 198 ELPEV-----------LDQIQNLRELWMDNNALQVLPGSIG---KLKMLVYLDMSKNRI- 242
E + I L+ L + ++P + K ++ ++ SKN++
Sbjct: 379 SATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLC 438
Query: 243 ETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLE 302
E + E + D+ LS N L + + +L+KLT L + +N L LP + +L L+
Sbjct: 439 EIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQ 498
Query: 303 EFDCSCNELESLPSTIGYLHSLRTLAVDENFLPEL-PREIGSCKNVTVMSLRSNKLEFLP 361
+ S N + LP + + +L T+ + N + + P+++ +N+T + L++N L +P
Sbjct: 499 TINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIP 558
Query: 362 EEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAAL 396
E+G LR L L N + +P + +K AA+
Sbjct: 559 PELGNCVNLRTLLLDGNPFR-VPRAAILMKGTAAI 592
Score = 89.7 bits (221), Expect = 2e-17
Identities = 54/154 (35%), Positives = 80/154 (51%)
Query: 255 LEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESL 314
L L++S+N LQ L D + LL LT L + DNQLT LP+ I L L++ + S N+L+ L
Sbjct: 84 LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKIL 143
Query: 315 PSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLN 374
P I L +L+ L + N L + N+ + L +N L +P + L LN
Sbjct: 144 PEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLN 203
Query: 375 LSDNRLKNLPFSFTKLKELAALWLSDNQSKALIP 408
LS N LK+LP ++K L L + N + + P
Sbjct: 204 LSSNELKSLPAEINRMKRLKHLDCNSNLLETIPP 237
Score = 63.5 bits (153), Expect = 1e-09
Identities = 56/225 (24%), Positives = 96/225 (42%), Gaps = 27/225 (12%)
Query: 24 ISVLDYSHCSLQQVPKEVFNFERT--LEELYLDANQIEELPKQLFNCQAL-RKLSIPDND 80
+ +LDYS +P EVF+ ++ + + NQ+ E+PK++ + + + + N
Sbjct: 401 LKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNK 460
Query: 81 LSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNL 140
LS + + L L LD+ N + PE ++ L I S N LP+
Sbjct: 461 LSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPE-------- 512
Query: 141 TQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTL-PKSMHKLAQLERLDLGNNEFGEL 199
LY R+ L + + N + ++ P+ M + L LDL NN+ ++
Sbjct: 513 -VLY--------------RIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQI 557
Query: 200 PEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIET 244
P L NLR L +D N +V +I L+ ++RI T
Sbjct: 558 PPELGNCVNLRTLLLDGNPFRVPRAAILMKGTAAILEYLRDRIPT 602
Score = 39.7 bits (91), Expect = 0.023
Identities = 20/61 (32%), Positives = 39/61 (63%)
Query: 346 NVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKA 405
++T + + +NKL+ L +++ + L VL++ DN+L +LP + +L+ L L +S N+ K
Sbjct: 83 DLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKI 142
Query: 406 L 406
L
Sbjct: 143 L 143
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 138 bits (348), Expect = 4e-32
Identities = 96/292 (32%), Positives = 140/292 (47%), Gaps = 2/292 (0%)
Query: 1 MTTKRKIIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEE 60
+ +R RL P G ++ LD SH L + EV + R L +L L NQ+
Sbjct: 92 LVLRRNRFARLPPAVAELGHH--LTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPA 149
Query: 61 LPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTII 120
LP QL L +L + N L++LP +++ L L+ LD+ N + FP + L +
Sbjct: 150 LPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEEL 209
Query: 121 EASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSM 180
+ S N + LP+ + L L L+L+ A L LPA F L L L L N L+ LP
Sbjct: 210 DVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQF 269
Query: 181 HKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKN 240
L +L+ L+L +N F E P L + L EL++ N L +P I L L+ L + N
Sbjct: 270 SCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNN 329
Query: 241 RIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLP 292
RI + I LE+L+L N + LPD G L ++ K+ DN L P
Sbjct: 330 RIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPP 381
Score = 134 bits (336), Expect = 9e-31
Identities = 99/316 (31%), Positives = 153/316 (48%), Gaps = 3/316 (0%)
Query: 89 ASLVNLKELDISKNGVQEFPENI-KCCKCLTIIEASVNPISKLPDGFTQL-LNLTQLYLN 146
A+L +++ L++ NG++E PE + L ++ N ++LP +L +LT+L ++
Sbjct: 60 ANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVS 119
Query: 147 DAFLEFLPANF-GRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQ 205
L L A L +LR L L N L LP + LA LE LD+ N LP+ L
Sbjct: 120 HNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSC 179
Query: 206 IQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNML 265
+ LR L +D+N L P + +L L LD+S NR+ + DIS AL+ L LS L
Sbjct: 180 LSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAEL 239
Query: 266 QQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLR 325
LP L L +L +D+N L LP L L+ + S N E P+ + L L
Sbjct: 240 GTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLE 299
Query: 326 TLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPF 385
L + N L +P I + + L +N++ +LP+ I ++ L L L N++ LP
Sbjct: 300 ELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPD 359
Query: 386 SFTKLKELAALWLSDN 401
F +L + + DN
Sbjct: 360 HFGQLSRVGLWKIKDN 375
Score = 131 bits (330), Expect = 4e-30
Identities = 96/320 (30%), Positives = 155/320 (48%), Gaps = 2/320 (0%)
Query: 24 ISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNC-QALRKLSIPDNDLS 82
I L+ + L++VP+ + + +L L L N+ LP + L +L + N L+
Sbjct: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLT 124
Query: 83 NLPTTIAS-LVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLT 141
L + S L L++L++S N + P + L ++ S N ++ LPD + L L
Sbjct: 125 ALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLR 184
Query: 142 QLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPE 201
L ++ L P +LV L L++ N L+ LP+ + L L+ L L E G LP
Sbjct: 185 TLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPA 244
Query: 202 VLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLS 261
++ +L L +DNN LQ LP L+ L L++S N E + LE+L LS
Sbjct: 245 GFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLS 304
Query: 262 SNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYL 321
N L +P I L +L TL +D+N++ LP++I L+ LEE N++ LP G L
Sbjct: 305 RNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQL 364
Query: 322 HSLRTLAVDENFLPELPREI 341
+ + +N L + P E+
Sbjct: 365 SRVGLWKIKDNPLIQPPYEV 384
Score = 124 bits (312), Expect = 5e-28
Identities = 96/286 (33%), Positives = 136/286 (47%), Gaps = 29/286 (10%)
Query: 120 IEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGR-LVKLRILELRENHLKTLPK 178
+E+ +P LP L ++ L L + LE +P G L LR+L LR N LP
Sbjct: 48 LESPASPQLVLP---ANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPP 104
Query: 179 SMHKLAQ-LERLDLGNNEFGEL-PEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLD 236
++ +L L LD+ +N L EV+ ++ LR+L + +N L LP +G L L LD
Sbjct: 105 AVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELD 164
Query: 237 MSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIG 296
+S NR L LPDS+ L +L TL VD NQLT P +
Sbjct: 165 VSFNR-----------------------LAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLL 201
Query: 297 NLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNK 356
L LEE D S N L LP I L +L+ L + L LP ++ + L +N
Sbjct: 202 QLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNG 261
Query: 357 LEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQ 402
L+ LP + +Q+L++LNLS N + P + L L L+LS NQ
Sbjct: 262 LQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQ 307
>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
Length = 335
Score = 131 bits (329), Expect = 6e-30
Identities = 80/218 (36%), Positives = 120/218 (55%), Gaps = 1/218 (0%)
Query: 165 ILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPG 224
IL++ + KTLP S+ KL QL+ L ++PE + + QNL L + N + +P
Sbjct: 64 ILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPP 123
Query: 225 SIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNM-LQQLPDSIGLLKKLTTLKV 283
IG L L L +S N+I+TV ++S C +LE L L+ N + LP + L KLT L +
Sbjct: 124 GIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDL 183
Query: 284 DDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGS 343
N T +P + N+ LE D N+LE LP TI + +L TL + N + LP+ I +
Sbjct: 184 SMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISN 243
Query: 344 CKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLK 381
KN+ + L +NKL+ +P + +M LR +N DN LK
Sbjct: 244 MKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLK 281
Score = 95.5 bits (236), Expect = 3e-19
Identities = 64/227 (28%), Positives = 110/227 (48%), Gaps = 4/227 (1%)
Query: 51 LYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPEN 110
L ++ + + LP L L++ + L +P I NL LD+S+N + E P
Sbjct: 65 LKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPG 124
Query: 111 IKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLN-DAFLEFLPANFGRLVKLRILELR 169
I L + S N I +P + +L +L L + + LP L+KL L+L
Sbjct: 125 IGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLS 184
Query: 170 ENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKL 229
N T+P ++ + LE LD+G+N+ +LP+ ++++QNL LW+ N + LP +I +
Sbjct: 185 MNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNM 244
Query: 230 KMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQ---QLPDSIG 273
K L L +S N+++ + + + L + N L+ LP S G
Sbjct: 245 KNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEG 291
Score = 94.0 bits (232), Expect = 1e-18
Identities = 67/248 (27%), Positives = 121/248 (48%), Gaps = 1/248 (0%)
Query: 44 FERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNG 103
F+ L ++ + + +L +++ L I + LP+++ L L+E + + G
Sbjct: 35 FQHKLVRIWEERVSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTG 94
Query: 104 VQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKL 163
+ + PE I + L +++ S N IS++P G L L +L L+ ++ +P L
Sbjct: 95 LLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASL 154
Query: 164 RILELRENH-LKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVL 222
LEL N + LP+ + L +L LDL N+F +P + + L L M +N L+ L
Sbjct: 155 EKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQL 214
Query: 223 PGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLK 282
P +I +++ L L + +N I + IS + L L+LS+N LQ +P + + L +
Sbjct: 215 PDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVN 274
Query: 283 VDDNQLTM 290
DN L +
Sbjct: 275 FRDNPLKL 282
Score = 75.9 bits (185), Expect = 3e-13
Identities = 50/199 (25%), Positives = 96/199 (48%), Gaps = 1/199 (0%)
Query: 209 LRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQL 268
L +W + +L L + + V L + K +T+ + L++ L L ++
Sbjct: 39 LVRIWEERVSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKI 98
Query: 269 PDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLA 328
P+ IG + L L + N ++ +P IG L+ L+E S N+++++P + SL L
Sbjct: 99 PEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLE 158
Query: 329 VDEN-FLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSF 387
+ N + +LP+E+ + +T + L N +P + M L L++ N+L+ LP +
Sbjct: 159 LAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTI 218
Query: 388 TKLKELAALWLSDNQSKAL 406
+++ L LWL N+ L
Sbjct: 219 ERMQNLHTLWLQRNEITCL 237
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 129 bits (323), Expect = 3e-29
Identities = 104/343 (30%), Positives = 169/343 (49%), Gaps = 19/343 (5%)
Query: 94 LKELDISKNGVQE--FPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLE 151
++ +D+S N + FPEN+K L ++ + + LP+ L L L ++ L
Sbjct: 10 VRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLT 69
Query: 152 FLPANFGRLVKLRILELRENHLKT--LPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNL 209
L L LR + R N LK +P + KL L LDL +N+ E P L+ +N+
Sbjct: 70 TLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNM 129
Query: 210 RELWMDNNALQVLPGSIG-KLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSN----- 263
L + +N++ +P + L L+YLD+S+NR+E++ + L+ L+L+ N
Sbjct: 130 LVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHA 189
Query: 264 MLQQLPDSIGLLKKLTTLKVDDNQLTM--LPNTIGNLSLLEEFDCSCNELESLPSTIGYL 321
L+QLP + L TL + Q T LP ++ LS L + D SCN+L +P + L
Sbjct: 190 QLRQLP----AMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTL 245
Query: 322 HSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRL- 380
SLR L + N + EL I +V ++L N+L LP I ++ KL+ L L+ N+L
Sbjct: 246 PSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLD 305
Query: 381 -KNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVL 422
LP KL L +++ N + L+P P+ ++ VL
Sbjct: 306 FDGLPSGIGKLTNLEE-FMAANNNLELVPESLCRCPKLRKLVL 347
Score = 125 bits (315), Expect = 2e-28
Identities = 105/343 (30%), Positives = 169/343 (49%), Gaps = 9/343 (2%)
Query: 27 LDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSN--L 84
L + L +P+E+ ++ LE L + N + L +L + +LR + N L N +
Sbjct: 38 LKLNRTGLCYLPEELAALQK-LEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGV 96
Query: 85 PTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDG-FTQLLNLTQL 143
P I L +L LD+S N + E P ++ K + ++ S N I +P+ F L +L L
Sbjct: 97 PDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYL 156
Query: 144 YLNDAFLEFLPANFGRLVKLRILELRENHLKTLP-KSMHKLAQLERLDLGNNEFGE--LP 200
L++ LE LP RLV L+ L L N L + + + L+ L L + + + LP
Sbjct: 157 DLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLP 216
Query: 201 EVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLL 260
L+ + NL ++ + N L +P + L L L++S N+I + + I +E L L
Sbjct: 217 TSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNL 276
Query: 261 SSNMLQQLPDSIGLLKKLTTLKVDDNQLTM--LPNTIGNLSLLEEFDCSCNELESLPSTI 318
S N L LP +I L KL L ++ N+L LP+ IG L+ LEEF + N LE +P ++
Sbjct: 277 SRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESL 336
Query: 319 GYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLP 361
LR L +++N L LP I + V+ +R N +P
Sbjct: 337 CRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMP 379
Score = 120 bits (302), Expect = 8e-27
Identities = 105/367 (28%), Positives = 173/367 (47%), Gaps = 25/367 (6%)
Query: 47 TLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQE 106
+L L L+ + LP++L Q L LS+ N+L+ L ++SL +L+ + N ++
Sbjct: 34 SLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKN 93
Query: 107 --FPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPAN-FGRLVKL 163
P++I L++++ S N +++ P N+ L L+ ++ +P F L L
Sbjct: 94 SGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDL 153
Query: 164 RILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLP 223
L+L EN L++LP M +L L+ L L N P + Q++ L + ALQ L
Sbjct: 154 LYLDLSENRLESLPPQMRRLVHLQTLVLNGN-----PLLHAQLRQLPAM----TALQTL- 203
Query: 224 GSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKV 283
+L ++ + + G L D+ LS N L ++P+ + L L L +
Sbjct: 204 ----------HLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNL 253
Query: 284 DDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLP--ELPREI 341
NQ+T L I +E + S N+L SLPS I L L+ L ++ N L LP I
Sbjct: 254 SSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGI 313
Query: 342 GSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDN 401
G N+ +N LE +PE + + KLR L L+ N L LP + L E+ L + +N
Sbjct: 314 GKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVREN 373
Query: 402 QSKALIP 408
+ + P
Sbjct: 374 PNLVMPP 380
Score = 107 bits (268), Expect = 7e-23
Identities = 83/277 (29%), Positives = 134/277 (48%), Gaps = 11/277 (3%)
Query: 24 ISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLF-NCQALRKLSIPDNDLS 82
+SVLD SH L + P+E+ N + L L L N I+ +P QLF N L L + +N L
Sbjct: 106 LSVLDLSHNQLTECPRELENAKNML-VLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLE 164
Query: 83 NLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIE-----ASVNPISKLPDGFTQL 137
+LP + LV+L+ L + NG ++ +T ++ ++ S LP L
Sbjct: 165 SLPPQMRRLVHLQTLVL--NGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGL 222
Query: 138 LNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFG 197
NL + L+ L +P L LR L L N + L + + +E L+L N+
Sbjct: 223 SNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLT 282
Query: 198 ELPEVLDQIQNLRELWMDNNALQV--LPGSIGKLKMLVYLDMSKNRIETVDMDISGCEAL 255
LP + ++ L++L++++N L LP IGKL L + N +E V + C L
Sbjct: 283 SLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKL 342
Query: 256 EDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLP 292
L+L+ N L LP++I L ++ L V +N ++P
Sbjct: 343 RKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMP 379
>gi|19923729 leucine rich repeat containing 8 family, member C [Homo
sapiens]
Length = 803
Score = 118 bits (296), Expect = 4e-26
Identities = 90/308 (29%), Positives = 149/308 (48%), Gaps = 41/308 (13%)
Query: 71 LRKLSIPDNDLSNLPTTIASLVNLKEL--------DISKNGVQEFPENIKCCKCLTIIEA 122
L+ LS+ +D+ LP + L NL+EL DIS+N E ++K K L+I
Sbjct: 493 LKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSI--- 549
Query: 123 SVNPISKLP-------------------------DGFTQLLNLTQLYLNDAFLEFLPANF 157
+ +SK+P + ++ NLT+L L LE +P
Sbjct: 550 -KSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAV 608
Query: 158 GRLVKLRILELRENHLKTLPK--SMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMD 215
L+ L+ L+L+EN+LK++ + S L +L L L +N +PE + ++ +L L
Sbjct: 609 FSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFS 668
Query: 216 NNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLL 275
+N ++VLP + + YLD+S N I + +I ++L+ ++ N ++ LPD +
Sbjct: 669 HNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFC 728
Query: 276 KKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRT--LAVDENF 333
KKL TLK+ N L++L IGNL L D N E LP +G +L+ L V++
Sbjct: 729 KKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRAGLVVEDAL 788
Query: 334 LPELPREI 341
LP ++
Sbjct: 789 FETLPSDV 796
Score = 104 bits (260), Expect = 6e-22
Identities = 96/363 (26%), Positives = 172/363 (47%), Gaps = 24/363 (6%)
Query: 51 LYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPEN 110
L L + LP +F L+ L + +P TIA L NL+EL + + V+
Sbjct: 426 LELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAA 485
Query: 111 IKCCK-CLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELR 169
+ K L ++ + + +LP L NL +LYL + L + R V L
Sbjct: 486 LSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGS----LSHDISRNVTL------ 535
Query: 170 ENHLKTLPKSMHKLAQLERLDLGNNEFGELPE-VLDQIQNLRELWMDNNALQ-VLPGSIG 227
+S+ L L+ L + +N ++P+ V+D +L+++ + N+ + V+ ++
Sbjct: 536 --------ESLRDLKSLKILSIKSN-VSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLK 586
Query: 228 KLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGL--LKKLTTLKVDD 285
K+ L L++ +E + + +L++L L N L+ + + + L+KLT LK+
Sbjct: 587 KMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWH 646
Query: 286 NQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCK 345
N +T +P I L+ LE S N++E LPS + + +R L + N + +P EIG +
Sbjct: 647 NSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQ 706
Query: 346 NVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKA 405
++ S+ NK+E LP+E+ +KL+ L + N L L L L+ L + N +
Sbjct: 707 SLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEI 766
Query: 406 LIP 408
L P
Sbjct: 767 LPP 769
Score = 71.2 bits (173), Expect = 7e-12
Identities = 49/166 (29%), Positives = 79/166 (47%), Gaps = 3/166 (1%)
Query: 24 ISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSN 83
++VL H S+ +P+ + +LE L N+IE LP LF C +R L + ND+
Sbjct: 639 LTVLKLWHNSITYIPEHIKKLT-SLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRF 697
Query: 84 LPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQL 143
+P I L +L+ I+ N V+ P+ + CK L ++ N +S L LL L+ L
Sbjct: 698 IPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYL 757
Query: 144 YLNDAFLEFLPANFG--RLVKLRILELRENHLKTLPKSMHKLAQLE 187
+ E LP G R +K L + + +TLP + + + E
Sbjct: 758 DVKGNHFEILPPELGDCRALKRAGLVVEDALFETLPSDVREQMKTE 803
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 118 bits (295), Expect = 5e-26
Identities = 103/361 (28%), Positives = 166/361 (45%), Gaps = 37/361 (10%)
Query: 51 LYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQE---- 106
LY A +IE P F + LR L I D+ +P I SL L+EL ++ N E
Sbjct: 476 LYHTAAKIEA-PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRY 534
Query: 107 -FPENIKCCKCLTIIEASVNPISKLPDGFTQL-LNLTQLYLNDAFLEFLPAN-FGRLVKL 163
+ ++ K L ++ N +SKLP T + ++L +L +N+ + + N ++ L
Sbjct: 535 IVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANL 593
Query: 164 RILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLP 223
LEL L+ +P S+ L L+ +DL +N + E++
Sbjct: 594 TELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEII-------------------- 633
Query: 224 GSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKV 283
S L L L + N I + + I LE L L+ N ++++P + +KL L +
Sbjct: 634 -SFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDL 692
Query: 284 DDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGS 343
N LT LP IG L L+ + N +E+LP + LR L + N L LP +G
Sbjct: 693 SHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGE 752
Query: 344 CKNVTVMSLRSNKLEFLPEEIGQ--MQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDN 401
N+T + LR N+LE LP E+G+ + K L + ++ LP ++KE LW +D
Sbjct: 753 LTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLP---PEVKE--RLWRADK 807
Query: 402 Q 402
+
Sbjct: 808 E 808
Score = 116 bits (290), Expect = 2e-25
Identities = 88/289 (30%), Positives = 149/289 (51%), Gaps = 9/289 (3%)
Query: 22 EIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLF--NCQALRKLSIP-- 77
E + L ++++P +++ +TLEEL+L N E + + + L++L +
Sbjct: 493 ENLRALHIKFTDIKEIPLWIYSL-KTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRL 551
Query: 78 DNDLSNLPTTIASL-VNLKELDISKNGVQEFPEN-IKCCKCLTIIEASVNPISKLPDGFT 135
++LS LP + + V+L++L I+ G + N +K LT +E + ++P
Sbjct: 552 KSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIF 611
Query: 136 QLLNLTQLYLNDAFLEFLPA--NFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGN 193
L NL ++ L D L+ + +F L +L L+L NH+ +P + L LERL L
Sbjct: 612 SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR 671
Query: 194 NEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCE 253
N+ ++P L + LR L + +N L LP IG L+ L L ++ NRIET+ ++ C
Sbjct: 672 NKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCR 731
Query: 254 ALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLE 302
L L L +N+LQ LP +G L LT +++ N+L LP +G LL+
Sbjct: 732 KLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
Score = 111 bits (277), Expect = 6e-24
Identities = 99/394 (25%), Positives = 177/394 (44%), Gaps = 55/394 (13%)
Query: 45 ERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGV 104
E L +L L+ + +Q A KL + LS +P T+ LV L+
Sbjct: 399 ENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELE--------- 449
Query: 105 QEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEF-LPANFGRLVKL 163
+++ + P +P QL L +L+L + PA L
Sbjct: 450 --------------VLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENL 495
Query: 164 RILELRENHLKTLPKSMHKLAQLERLDLGNN---------------------------EF 196
R L ++ +K +P ++ L LE L L N
Sbjct: 496 RALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNL 555
Query: 197 GELPEVLDQIQ-NLRELWMDNNALQVLP-GSIGKLKMLVYLDMSKNRIETVDMDISGCEA 254
+LP+V+ + +L++L ++N +++ S+ K+ L L++ + +E + I
Sbjct: 556 SKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHN 615
Query: 255 LEDLLLSSNMLQQLPDSIGL--LKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELE 312
L+++ L N L+ + + I L +LT LK+ N + +P IGNL+ LE + N++E
Sbjct: 616 LQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIE 675
Query: 313 SLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRV 372
+P+ + Y LR L + N L LP +IG +N+ +++ +N++E LP E+ Q +KLR
Sbjct: 676 KIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRA 735
Query: 373 LNLSDNRLKNLPFSFTKLKELAALWLSDNQSKAL 406
L+L +N L++LP +L L + L N+ + L
Sbjct: 736 LHLGNNVLQSLPSRVGELTNLTQIELRGNRLECL 769
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 118 bits (295), Expect = 5e-26
Identities = 103/361 (28%), Positives = 166/361 (45%), Gaps = 37/361 (10%)
Query: 51 LYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQE---- 106
LY A +IE P F + LR L I D+ +P I SL L+EL ++ N E
Sbjct: 476 LYHTAAKIEA-PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRY 534
Query: 107 -FPENIKCCKCLTIIEASVNPISKLPDGFTQL-LNLTQLYLNDAFLEFLPAN-FGRLVKL 163
+ ++ K L ++ N +SKLP T + ++L +L +N+ + + N ++ L
Sbjct: 535 IVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANL 593
Query: 164 RILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLP 223
LEL L+ +P S+ L L+ +DL +N + E++
Sbjct: 594 TELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEII-------------------- 633
Query: 224 GSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKV 283
S L L L + N I + + I LE L L+ N ++++P + +KL L +
Sbjct: 634 -SFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDL 692
Query: 284 DDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGS 343
N LT LP IG L L+ + N +E+LP + LR L + N L LP +G
Sbjct: 693 SHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGE 752
Query: 344 CKNVTVMSLRSNKLEFLPEEIGQ--MQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDN 401
N+T + LR N+LE LP E+G+ + K L + ++ LP ++KE LW +D
Sbjct: 753 LTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLP---PEVKE--RLWRADK 807
Query: 402 Q 402
+
Sbjct: 808 E 808
Score = 116 bits (290), Expect = 2e-25
Identities = 88/289 (30%), Positives = 149/289 (51%), Gaps = 9/289 (3%)
Query: 22 EIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLF--NCQALRKLSIP-- 77
E + L ++++P +++ +TLEEL+L N E + + + L++L +
Sbjct: 493 ENLRALHIKFTDIKEIPLWIYSL-KTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRL 551
Query: 78 DNDLSNLPTTIASL-VNLKELDISKNGVQEFPEN-IKCCKCLTIIEASVNPISKLPDGFT 135
++LS LP + + V+L++L I+ G + N +K LT +E + ++P
Sbjct: 552 KSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIF 611
Query: 136 QLLNLTQLYLNDAFLEFLPA--NFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGN 193
L NL ++ L D L+ + +F L +L L+L NH+ +P + L LERL L
Sbjct: 612 SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR 671
Query: 194 NEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCE 253
N+ ++P L + LR L + +N L LP IG L+ L L ++ NRIET+ ++ C
Sbjct: 672 NKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCR 731
Query: 254 ALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLE 302
L L L +N+LQ LP +G L LT +++ N+L LP +G LL+
Sbjct: 732 KLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
Score = 111 bits (277), Expect = 6e-24
Identities = 99/394 (25%), Positives = 177/394 (44%), Gaps = 55/394 (13%)
Query: 45 ERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGV 104
E L +L L+ + +Q A KL + LS +P T+ LV L+
Sbjct: 399 ENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELE--------- 449
Query: 105 QEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEF-LPANFGRLVKL 163
+++ + P +P QL L +L+L + PA L
Sbjct: 450 --------------VLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENL 495
Query: 164 RILELRENHLKTLPKSMHKLAQLERLDLGNN---------------------------EF 196
R L ++ +K +P ++ L LE L L N
Sbjct: 496 RALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNL 555
Query: 197 GELPEVLDQIQ-NLRELWMDNNALQVLP-GSIGKLKMLVYLDMSKNRIETVDMDISGCEA 254
+LP+V+ + +L++L ++N +++ S+ K+ L L++ + +E + I
Sbjct: 556 SKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHN 615
Query: 255 LEDLLLSSNMLQQLPDSIGL--LKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELE 312
L+++ L N L+ + + I L +LT LK+ N + +P IGNL+ LE + N++E
Sbjct: 616 LQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIE 675
Query: 313 SLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRV 372
+P+ + Y LR L + N L LP +IG +N+ +++ +N++E LP E+ Q +KLR
Sbjct: 676 KIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRA 735
Query: 373 LNLSDNRLKNLPFSFTKLKELAALWLSDNQSKAL 406
L+L +N L++LP +L L + L N+ + L
Sbjct: 736 LHLGNNVLQSLPSRVGELTNLTQIELRGNRLECL 769
>gi|187829871 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 118 bits (295), Expect = 5e-26
Identities = 103/361 (28%), Positives = 166/361 (45%), Gaps = 37/361 (10%)
Query: 51 LYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQE---- 106
LY A +IE P F + LR L I D+ +P I SL L+EL ++ N E
Sbjct: 476 LYHTAAKIEA-PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRY 534
Query: 107 -FPENIKCCKCLTIIEASVNPISKLPDGFTQL-LNLTQLYLNDAFLEFLPAN-FGRLVKL 163
+ ++ K L ++ N +SKLP T + ++L +L +N+ + + N ++ L
Sbjct: 535 IVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANL 593
Query: 164 RILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLP 223
LEL L+ +P S+ L L+ +DL +N + E++
Sbjct: 594 TELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEII-------------------- 633
Query: 224 GSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKV 283
S L L L + N I + + I LE L L+ N ++++P + +KL L +
Sbjct: 634 -SFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDL 692
Query: 284 DDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGS 343
N LT LP IG L L+ + N +E+LP + LR L + N L LP +G
Sbjct: 693 SHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGE 752
Query: 344 CKNVTVMSLRSNKLEFLPEEIGQ--MQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDN 401
N+T + LR N+LE LP E+G+ + K L + ++ LP ++KE LW +D
Sbjct: 753 LTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLP---PEVKE--RLWRADK 807
Query: 402 Q 402
+
Sbjct: 808 E 808
Score = 116 bits (290), Expect = 2e-25
Identities = 88/289 (30%), Positives = 149/289 (51%), Gaps = 9/289 (3%)
Query: 22 EIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLF--NCQALRKLSIP-- 77
E + L ++++P +++ +TLEEL+L N E + + + L++L +
Sbjct: 493 ENLRALHIKFTDIKEIPLWIYSL-KTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRL 551
Query: 78 DNDLSNLPTTIASL-VNLKELDISKNGVQEFPEN-IKCCKCLTIIEASVNPISKLPDGFT 135
++LS LP + + V+L++L I+ G + N +K LT +E + ++P
Sbjct: 552 KSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIF 611
Query: 136 QLLNLTQLYLNDAFLEFLPA--NFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGN 193
L NL ++ L D L+ + +F L +L L+L NH+ +P + L LERL L
Sbjct: 612 SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR 671
Query: 194 NEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCE 253
N+ ++P L + LR L + +N L LP IG L+ L L ++ NRIET+ ++ C
Sbjct: 672 NKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCR 731
Query: 254 ALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLE 302
L L L +N+LQ LP +G L LT +++ N+L LP +G LL+
Sbjct: 732 KLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
Score = 111 bits (277), Expect = 6e-24
Identities = 99/394 (25%), Positives = 177/394 (44%), Gaps = 55/394 (13%)
Query: 45 ERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGV 104
E L +L L+ + +Q A KL + LS +P T+ LV L+
Sbjct: 399 ENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELE--------- 449
Query: 105 QEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEF-LPANFGRLVKL 163
+++ + P +P QL L +L+L + PA L
Sbjct: 450 --------------VLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENL 495
Query: 164 RILELRENHLKTLPKSMHKLAQLERLDLGNN---------------------------EF 196
R L ++ +K +P ++ L LE L L N
Sbjct: 496 RALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNL 555
Query: 197 GELPEVLDQIQ-NLRELWMDNNALQVLP-GSIGKLKMLVYLDMSKNRIETVDMDISGCEA 254
+LP+V+ + +L++L ++N +++ S+ K+ L L++ + +E + I
Sbjct: 556 SKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHN 615
Query: 255 LEDLLLSSNMLQQLPDSIGL--LKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELE 312
L+++ L N L+ + + I L +LT LK+ N + +P IGNL+ LE + N++E
Sbjct: 616 LQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIE 675
Query: 313 SLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRV 372
+P+ + Y LR L + N L LP +IG +N+ +++ +N++E LP E+ Q +KLR
Sbjct: 676 KIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRA 735
Query: 373 LNLSDNRLKNLPFSFTKLKELAALWLSDNQSKAL 406
L+L +N L++LP +L L + L N+ + L
Sbjct: 736 LHLGNNVLQSLPSRVGELTNLTQIELRGNRLECL 769
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 117 bits (292), Expect = 1e-25
Identities = 89/323 (27%), Positives = 161/323 (49%), Gaps = 31/323 (9%)
Query: 71 LRKLSIPDNDLSNLPTTIASLVNLKELDI-----SKNGVQEFPENIKCCKCLTIIEASVN 125
LR L + D++ +P + L NL+EL + S+N E+++ + L I+ N
Sbjct: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598
Query: 126 PISKLPDGFTQLL-NLTQLYLNDAFLEFLPAN-FGRLVKLRILELRENHLKTLPKSMHKL 183
++K+P T + +LT+L +++ + L N +++ + LEL+ L+ +P ++ L
Sbjct: 599 -LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSL 657
Query: 184 AQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIE 243
+ L+ LDL +N + E++ S LK L L + N+I
Sbjct: 658 SNLQELDLKSNNIRTIEEII---------------------SFQHLKRLTCLKLWHNKIV 696
Query: 244 TVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEE 303
T+ I+ + LE L S+N L+ LP ++ L+KL L V N ++M+P IG L L+
Sbjct: 697 TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQH 756
Query: 304 FDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEE 363
+ N+++ LP + LRTL + +N + LP ++G +T + L+ N L+ LP +
Sbjct: 757 LHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQ 816
Query: 364 IGQMQKLRV--LNLSDNRLKNLP 384
+GQ + L+ L + D+ LP
Sbjct: 817 LGQCRMLKKSGLVVEDHLFDTLP 839
Score = 107 bits (266), Expect = 1e-22
Identities = 95/378 (25%), Positives = 174/378 (46%), Gaps = 42/378 (11%)
Query: 42 FNFERTLEELYLDANQIEEL--------PKQLFNCQALRKLSIPDNDLSNLPTTIASLVN 93
+ FE+ + + +A +EL P +F+ L L + + +P I+ + N
Sbjct: 455 WTFEKLRQHISRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTN 514
Query: 94 LKELD-------ISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLN 146
L+EL + + ++++C + ++++P L NL +LYL
Sbjct: 515 LQELHLCHCPAKVEQTAFSFLRDHLRC------LHVKFTDVAEIPAWVYLLKNLRELYL- 567
Query: 147 DAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQI 206
G L EN+ +S+ +L L+ L + +N + D
Sbjct: 568 ----------IGNLNS-------ENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVA 610
Query: 207 QNLRELWMDNNALQVLP-GSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNML 265
+L +L + N+ ++L S+ K+ + L++ +E + I L++L L SN +
Sbjct: 611 PHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNI 670
Query: 266 QQLPDSIGL--LKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHS 323
+ + + I LK+LT LK+ N++ +P +I ++ LE S N+LESLP + L
Sbjct: 671 RTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQK 730
Query: 324 LRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNL 383
LR L V N + +P EIG +N+ + + NK++ LP+++ + KLR LNL N + +L
Sbjct: 731 LRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSL 790
Query: 384 PFSFTKLKELAALWLSDN 401
P +L +L L L N
Sbjct: 791 PEKVGQLSQLTQLELKGN 808
Score = 77.8 bits (190), Expect = 8e-14
Identities = 73/291 (25%), Positives = 134/291 (46%), Gaps = 21/291 (7%)
Query: 127 ISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLA-- 184
+S +PD L +L L L +PA ++ L+ E HL P + + A
Sbjct: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQ-----ELHLCHCPAKVEQTAFS 533
Query: 185 ----QLERLDLGNNEFGELPEVLDQIQNLRELWM------DNNALQVLPGSIGKLKMLVY 234
L L + + E+P + ++NLREL++ +NN + L S+ +L+ L
Sbjct: 534 FLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLE-SLRELRHLKI 592
Query: 235 LDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLP-DSIGLLKKLTTLKVDDNQLTMLPN 293
L + N + L L++ ++ + L +S+ + + L++ + +L +P+
Sbjct: 593 LHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPH 652
Query: 294 TIGNLSLLEEFDCSCNELESLPSTIGYLH--SLRTLAVDENFLPELPREIGSCKNVTVMS 351
I +LS L+E D N + ++ I + H L L + N + +P I KN+ +
Sbjct: 653 AIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLY 712
Query: 352 LRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQ 402
+NKLE LP + +QKLR L++S N + +P L+ L L ++ N+
Sbjct: 713 FSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNK 763
Score = 77.8 bits (190), Expect = 8e-14
Identities = 52/156 (33%), Positives = 80/156 (51%), Gaps = 3/156 (1%)
Query: 24 ISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSN 83
++ L H + +P + + + LE LY N++E LP +F+ Q LR L + N++S
Sbjct: 685 LTCLKLWHNKIVTIPPSITHV-KNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISM 743
Query: 84 LPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQL 143
+P I L NL+ L I+ N V P+ + C L + N I+ LP+ QL LTQL
Sbjct: 744 IPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQL 803
Query: 144 YLNDAFLEFLPANFG--RLVKLRILELRENHLKTLP 177
L L+ LPA G R++K L + ++ TLP
Sbjct: 804 ELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLP 839
Score = 72.0 bits (175), Expect = 4e-12
Identities = 58/226 (25%), Positives = 101/226 (44%), Gaps = 49/226 (21%)
Query: 24 ISVLDYSHCSLQQVPKEVFNFE------------RTLEE------------LYLDANQIE 59
++ L+ +C L+++P +F+ RT+EE L L N+I
Sbjct: 637 VAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIV 696
Query: 60 ELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTI 119
+P + + + L L +N L +LP + SL L+ LD+S N
Sbjct: 697 TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNN---------------- 740
Query: 120 IEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKS 179
IS +P L NL L++ ++ LP + +KLR L L +N + +LP+
Sbjct: 741 -------ISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEK 793
Query: 180 MHKLAQLERLDLGNNEFGELPEVLDQIQNLRE--LWMDNNALQVLP 223
+ +L+QL +L+L N LP L Q + L++ L ++++ LP
Sbjct: 794 VGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLP 839
>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
sapiens]
Length = 858
Score = 117 bits (292), Expect = 1e-25
Identities = 89/323 (27%), Positives = 161/323 (49%), Gaps = 31/323 (9%)
Query: 71 LRKLSIPDNDLSNLPTTIASLVNLKELDI-----SKNGVQEFPENIKCCKCLTIIEASVN 125
LR L + D++ +P + L NL+EL + S+N E+++ + L I+ N
Sbjct: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598
Query: 126 PISKLPDGFTQLL-NLTQLYLNDAFLEFLPAN-FGRLVKLRILELRENHLKTLPKSMHKL 183
++K+P T + +LT+L +++ + L N +++ + LEL+ L+ +P ++ L
Sbjct: 599 -LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSL 657
Query: 184 AQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIE 243
+ L+ LDL +N + E++ S LK L L + N+I
Sbjct: 658 SNLQELDLKSNNIRTIEEII---------------------SFQHLKRLTCLKLWHNKIV 696
Query: 244 TVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEE 303
T+ I+ + LE L S+N L+ LP ++ L+KL L V N ++M+P IG L L+
Sbjct: 697 TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQH 756
Query: 304 FDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEE 363
+ N+++ LP + LRTL + +N + LP ++G +T + L+ N L+ LP +
Sbjct: 757 LHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQ 816
Query: 364 IGQMQKLRV--LNLSDNRLKNLP 384
+GQ + L+ L + D+ LP
Sbjct: 817 LGQCRMLKKSGLVVEDHLFDTLP 839
Score = 107 bits (266), Expect = 1e-22
Identities = 95/378 (25%), Positives = 174/378 (46%), Gaps = 42/378 (11%)
Query: 42 FNFERTLEELYLDANQIEEL--------PKQLFNCQALRKLSIPDNDLSNLPTTIASLVN 93
+ FE+ + + +A +EL P +F+ L L + + +P I+ + N
Sbjct: 455 WTFEKLRQHISRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTN 514
Query: 94 LKELD-------ISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLN 146
L+EL + + ++++C + ++++P L NL +LYL
Sbjct: 515 LQELHLCHCPAKVEQTAFSFLRDHLRC------LHVKFTDVAEIPAWVYLLKNLRELYL- 567
Query: 147 DAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQI 206
G L EN+ +S+ +L L+ L + +N + D
Sbjct: 568 ----------IGNLNS-------ENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVA 610
Query: 207 QNLRELWMDNNALQVLP-GSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNML 265
+L +L + N+ ++L S+ K+ + L++ +E + I L++L L SN +
Sbjct: 611 PHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNI 670
Query: 266 QQLPDSIGL--LKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHS 323
+ + + I LK+LT LK+ N++ +P +I ++ LE S N+LESLP + L
Sbjct: 671 RTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQK 730
Query: 324 LRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNL 383
LR L V N + +P EIG +N+ + + NK++ LP+++ + KLR LNL N + +L
Sbjct: 731 LRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSL 790
Query: 384 PFSFTKLKELAALWLSDN 401
P +L +L L L N
Sbjct: 791 PEKVGQLSQLTQLELKGN 808
Score = 77.8 bits (190), Expect = 8e-14
Identities = 73/291 (25%), Positives = 134/291 (46%), Gaps = 21/291 (7%)
Query: 127 ISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLA-- 184
+S +PD L +L L L +PA ++ L+ E HL P + + A
Sbjct: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQ-----ELHLCHCPAKVEQTAFS 533
Query: 185 ----QLERLDLGNNEFGELPEVLDQIQNLRELWM------DNNALQVLPGSIGKLKMLVY 234
L L + + E+P + ++NLREL++ +NN + L S+ +L+ L
Sbjct: 534 FLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLE-SLRELRHLKI 592
Query: 235 LDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLP-DSIGLLKKLTTLKVDDNQLTMLPN 293
L + N + L L++ ++ + L +S+ + + L++ + +L +P+
Sbjct: 593 LHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPH 652
Query: 294 TIGNLSLLEEFDCSCNELESLPSTIGYLH--SLRTLAVDENFLPELPREIGSCKNVTVMS 351
I +LS L+E D N + ++ I + H L L + N + +P I KN+ +
Sbjct: 653 AIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLY 712
Query: 352 LRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQ 402
+NKLE LP + +QKLR L++S N + +P L+ L L ++ N+
Sbjct: 713 FSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNK 763
Score = 77.8 bits (190), Expect = 8e-14
Identities = 52/156 (33%), Positives = 80/156 (51%), Gaps = 3/156 (1%)
Query: 24 ISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSN 83
++ L H + +P + + + LE LY N++E LP +F+ Q LR L + N++S
Sbjct: 685 LTCLKLWHNKIVTIPPSITHV-KNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISM 743
Query: 84 LPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQL 143
+P I L NL+ L I+ N V P+ + C L + N I+ LP+ QL LTQL
Sbjct: 744 IPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQL 803
Query: 144 YLNDAFLEFLPANFG--RLVKLRILELRENHLKTLP 177
L L+ LPA G R++K L + ++ TLP
Sbjct: 804 ELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLP 839
Score = 72.0 bits (175), Expect = 4e-12
Identities = 58/226 (25%), Positives = 101/226 (44%), Gaps = 49/226 (21%)
Query: 24 ISVLDYSHCSLQQVPKEVFNFE------------RTLEE------------LYLDANQIE 59
++ L+ +C L+++P +F+ RT+EE L L N+I
Sbjct: 637 VAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIV 696
Query: 60 ELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTI 119
+P + + + L L +N L +LP + SL L+ LD+S N
Sbjct: 697 TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNN---------------- 740
Query: 120 IEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKS 179
IS +P L NL L++ ++ LP + +KLR L L +N + +LP+
Sbjct: 741 -------ISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEK 793
Query: 180 MHKLAQLERLDLGNNEFGELPEVLDQIQNLRE--LWMDNNALQVLP 223
+ +L+QL +L+L N LP L Q + L++ L ++++ LP
Sbjct: 794 VGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLP 839
>gi|65301141 PH domain and leucine rich repeat protein
phosphatase-like [Homo sapiens]
Length = 1323
Score = 115 bits (287), Expect = 4e-25
Identities = 120/452 (26%), Positives = 209/452 (46%), Gaps = 75/452 (16%)
Query: 24 ISVLDYSHCSLQQVPKEVF------------NFERT--------------LEELYLDANQ 57
IS +D S SL++VP+ +F NF + L+ L L N+
Sbjct: 251 ISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNK 310
Query: 58 IEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCL 117
+ P L L +L++ N +LP+ I +L+NL+ L + N + PE + + L
Sbjct: 311 LGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQL 370
Query: 118 TIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPAN-FGRLVKLRILELRENHLKTL 176
+ + S N S++P+ + +L L ++ + LE L R+ ++ ++LR NHLKT+
Sbjct: 371 SSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTM 430
Query: 177 P-KSMHKLAQLERLDLGNNEFGELPE----VLDQI----QNLRELWMDNNALQVLPGSIG 227
+++ + +DL +N +L L+Q+ LREL + +L+ L S
Sbjct: 431 VIENLEGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSN 490
Query: 228 KL---------KMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLP----DSIGL 274
+L +L +LD+S+N +E V + +E L +S N+L ++P S+ L
Sbjct: 491 RLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSL 550
Query: 275 LK------------------KLTTLKVDDNQLTMLPNTIGNLSL-LEEFDCSCNELESLP 315
K L L + N LT LP+T+ + +L L + S N LESLP
Sbjct: 551 RKLMLGHNHVQNLPTLVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLP 610
Query: 316 STI---GYLHSLRTLAVDENFLPE--LPREIGSCKNVTVMSLRSNKLEFLP-EEIGQMQK 369
S L L+ L + N L + +P +G ++ ++ L +N+L+ P ++ ++++
Sbjct: 611 SACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHL-HLRILHLANNQLQTFPASKLNKLEQ 669
Query: 370 LRVLNLSDNRLKNLPFSFTKLKELAALWLSDN 401
L LNLS N+LK +P + K L L N
Sbjct: 670 LEELNLSGNKLKTIPTTIANCKRLHTLVAHSN 701
Score = 104 bits (259), Expect = 8e-22
Identities = 111/382 (29%), Positives = 171/382 (44%), Gaps = 56/382 (14%)
Query: 53 LDANQIEELPKQLFNCQALRKLSIPDNDLS-NLP---TTIASLVNLKELDISKNGVQEFP 108
L +EE+P+ LF Q + L++ N + P T+ LK L++S N + FP
Sbjct: 256 LSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGLFP 315
Query: 109 ENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILEL 168
I C+ T+ E LNL+ +D LP+ G L+ L+ L L
Sbjct: 316 --ILLCEISTLTE----------------LNLSCNGFHD-----LPSQIGNLLNLQTLCL 352
Query: 169 RENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLP-GSIG 227
N L TLP+ + L QL L + N F ++PEV +++ L + M N L+VL G +
Sbjct: 353 DGNFLTTLPEELGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLN 412
Query: 228 KLKMLVYLDMSKNRIETV----------------------DMDISGCEALEDLLLSSNML 265
++ + ++D+ N ++T+ D+D+S +LE L N L
Sbjct: 413 RMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQL 472
Query: 266 QQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLR 325
++L S G L TL N+LT + N SLL D S N LE +P +
Sbjct: 473 RELTLS-GF--SLRTLYASSNRLTAV-NVYPVPSLLTFLDLSRNLLECVPDWACEAKKIE 528
Query: 326 TLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPF 385
L V N L E+P I S ++ + L N ++ LP + + L VL+L N L LP
Sbjct: 529 VLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPTLVEHI-PLEVLDLQHNALTRLPD 587
Query: 386 S-FTKLKELAALWLSDNQSKAL 406
+ F+K L L S N ++L
Sbjct: 588 TLFSKALNLRYLNASANSLESL 609
Score = 92.0 bits (227), Expect = 4e-18
Identities = 81/286 (28%), Positives = 145/286 (50%), Gaps = 22/286 (7%)
Query: 47 TLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPT-TIASLVNLKELDISKNGVQ 105
+LE+L+ NQ+ EL F+ LR L N L+ + + SL+ LD+S+N ++
Sbjct: 461 SLEQLHCGRNQLRELTLSGFS---LRTLYASSNRLTAVNVYPVPSLLTF--LDLSRNLLE 515
Query: 106 EFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRI 165
P+ K + +++ S N ++++P L+L +L L ++ LP + L +
Sbjct: 516 CVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPTLVEH-IPLEV 574
Query: 166 LELRENHLKTLPKSMH-KLAQLERLDLGNNEFGELPEVL---DQIQNLRELWMDNNAL-- 219
L+L+ N L LP ++ K L L+ N LP + + L+ L++ NN L
Sbjct: 575 LDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTD 634
Query: 220 QVLPGSIGKLKMLVYLDMSKNRIETVDMD-ISGCEALEDLLLSSNMLQQLPDSIGLLKKL 278
Q +P +G L + + L ++ N+++T ++ E LE+L LS N L+ +P +I K+L
Sbjct: 635 QCIPVLVGHLHLRI-LHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIANCKRL 693
Query: 279 TTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNEL------ESLPSTI 318
TL N +++ P + L ++ D SCN+L E+LP+T+
Sbjct: 694 HTLVAHSNNISIFPEIL-QLPQIQFVDLSCNDLTEILIPEALPATL 738
Score = 84.3 bits (207), Expect = 8e-16
Identities = 107/419 (25%), Positives = 178/419 (42%), Gaps = 78/419 (18%)
Query: 20 EEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDN 79
E ++ L+ S +P ++ N L+ L LD N + LP++L N Q L L I N
Sbjct: 320 EISTLTELNLSCNGFHDLPSQIGNL-LNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFN 378
Query: 80 DLSNLPTTIASLV------------------------NLKELDISKNGVQEFP-ENIKCC 114
+ S +P L ++K +D+ N ++ EN++
Sbjct: 379 NFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGN 438
Query: 115 KCLTIIE-----------ASVNPISKLPDGFTQLLNLTQ--------------------- 142
K +T ++ +S+ + +L G QL LT
Sbjct: 439 KHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSNRLTAVNVY 498
Query: 143 --------LYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNN 194
L L+ LE +P K+ +L++ N L +P + L +L LG+N
Sbjct: 499 PVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHN 558
Query: 195 EFGELPEVLDQIQNLRELWMDNNALQVLPGSI-GKLKMLVYLDMSKNRIETVDMDISGCE 253
LP +++ I L L + +NAL LP ++ K L YL+ S N +E++ +G E
Sbjct: 559 HVQNLPTLVEHIP-LEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEE 617
Query: 254 AL---EDLLLSSNML--QQLPDSIGLLKKLTTLKVDDNQLTMLP-NTIGNLSLLEEFDCS 307
+L + L L++N+L Q +P +G L L L + +NQL P + + L LEE + S
Sbjct: 618 SLSMLQLLYLTNNLLTDQCIPVLVGHLH-LRILHLANNQLQTFPASKLNKLEQLEELNLS 676
Query: 308 CNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLE--FLPEEI 364
N+L+++P+TI L TL N + P EI + + L N L +PE +
Sbjct: 677 GNKLKTIPTTIANCKRLHTLVAHSNNISIFP-EILQLPQIQFVDLSCNDLTEILIPEAL 734
Score = 68.6 bits (166), Expect = 5e-11
Identities = 48/157 (30%), Positives = 78/157 (49%), Gaps = 14/157 (8%)
Query: 241 RIETVDMDISGCEALEDLLLSS----------NMLQ-QLPDSIGLLKKLTTLK---VDDN 286
RI TVD+ E + + L S N +Q + P + L K + LK + N
Sbjct: 250 RISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHN 309
Query: 287 QLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKN 346
+L + P + +S L E + SCN LPS IG L +L+TL +D NFL LP E+G+ +
Sbjct: 310 KLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQ 369
Query: 347 VTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNL 383
++ + + N +PE ++ L + ++ N L+ L
Sbjct: 370 LSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVL 406
>gi|40217803 leucine rich repeat containing 8 family, member E [Homo
sapiens]
Length = 796
Score = 114 bits (284), Expect = 9e-25
Identities = 100/351 (28%), Positives = 166/351 (47%), Gaps = 24/351 (6%)
Query: 61 LPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQ-EFPENIKCCKCLTI 119
LP +F + L + P ++ LV+L+EL + + + F + L +
Sbjct: 429 LPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSLQVFLRDHLKV 488
Query: 120 IEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKS 179
+ + ++P L L +L+L F P R L +S
Sbjct: 489 MRVKCEELREVPLWVFGLRGLEELHLEGLF----PQELARAATL--------------ES 530
Query: 180 MHKLAQLERLDLGNNEFGELP-EVLDQIQNLRELWMDNNALQVLP-GSIGKLKMLVYLDM 237
+ +L QL+ L L +N G++P V D +L+ L + N+ +++ S+ KL L L++
Sbjct: 531 LRELKQLKVLSLRSNA-GKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELEL 589
Query: 238 SKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGL--LKKLTTLKVDDNQLTMLPNTI 295
+E + + AL++L L N L+ + + + +KL TL++ NQ+ +P +
Sbjct: 590 VACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHV 649
Query: 296 GNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSN 355
L LE+ S N+LE+LPS +G LR L V N L LP E+G +N+ ++L N
Sbjct: 650 RKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYN 709
Query: 356 KLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKAL 406
LE LPEE+ +KLR L L DN+L L L+ L+ L L N+ +AL
Sbjct: 710 ALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEAL 760
Score = 109 bits (272), Expect = 2e-23
Identities = 94/330 (28%), Positives = 150/330 (45%), Gaps = 31/330 (9%)
Query: 64 QLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFP-----ENIKCCKCLT 118
Q+F L+ + + +L +P + L L+EL + QE E+++ K L
Sbjct: 479 QVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLK 538
Query: 119 IIEASVNPISKLPDGFTQLL-NLTQLYLNDAFLEFLPAN-FGRLVKLRILELRENHLKTL 176
++ N K+P T + +L +L L++ + N +L LR LEL L+ +
Sbjct: 539 VLSLRSNA-GKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERI 597
Query: 177 PKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLD 236
P ++ L L+ LDL +N + E+L S + LV L
Sbjct: 598 PHAVFSLGALQELDLKDNHLRSIEEIL---------------------SFQHCRKLVTLR 636
Query: 237 MSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIG 296
+ N+I V + +LE L LS N L+ LP +GL L L V N L LP +G
Sbjct: 637 LWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVG 696
Query: 297 NLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNK 356
L L+ S N LE+LP + + LRTL + +N L +L +G+ + ++ + L+ N+
Sbjct: 697 LLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNR 756
Query: 357 LEFLPEEIGQMQKLRVLNL--SDNRLKNLP 384
LE LPEE+G L+ L D + LP
Sbjct: 757 LEALPEELGNCGGLKKAGLLVEDTLYQGLP 786
Score = 74.7 bits (182), Expect = 6e-13
Identities = 49/147 (33%), Positives = 71/147 (48%), Gaps = 12/147 (8%)
Query: 23 IISVLDYSHC-----------SLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQAL 71
I +L + HC + VP+ V R+LE+LYL N++E LP QL C L
Sbjct: 620 IEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKL-RSLEQLYLSYNKLETLPSQLGLCSGL 678
Query: 72 RKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLP 131
R L + N L +LP + L NL+ L +S N ++ PE + C+ L + N +S+L
Sbjct: 679 RLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLS 738
Query: 132 DGFTQLLNLTQLYLNDAFLEFLPANFG 158
L L++L L LE LP G
Sbjct: 739 PHVGALRALSRLELKGNRLEALPEELG 765
Score = 66.2 bits (160), Expect = 2e-10
Identities = 54/188 (28%), Positives = 86/188 (45%), Gaps = 8/188 (4%)
Query: 11 LVPCRCFRGEEEIISV-----LDYSHCSLQQVPKEVFNFE--RTLEELYLDANQIEELPK 63
LV C R + S+ LD L+ + +E+ +F+ R L L L NQI +P+
Sbjct: 589 LVACGLERIPHAVFSLGALQELDLKDNHLRSI-EEILSFQHCRKLVTLRLWHNQIAYVPE 647
Query: 64 QLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEAS 123
+ ++L +L + N L LP+ + L+ LD+S NG+ P + + L + S
Sbjct: 648 HVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALS 707
Query: 124 VNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKL 183
N + LP+ L L L D L L + G L L LEL+ N L+ LP+ +
Sbjct: 708 YNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNC 767
Query: 184 AQLERLDL 191
L++ L
Sbjct: 768 GGLKKAGL 775
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 109 bits (273), Expect = 2e-23
Identities = 103/317 (32%), Positives = 147/317 (46%), Gaps = 31/317 (9%)
Query: 131 PDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLD 190
P G QLL+L L+ L F RL +L E L LP+S+ L L +
Sbjct: 44 PGGCQQLLHLCV----QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSL--VL 97
Query: 191 LGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDIS 250
G L L AL LP + L L +LD+S N +ET+ +
Sbjct: 98 KGGQRRDTLGACL------------RGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVL 145
Query: 251 GCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNE 310
L LLLS N L +LP+++G L LT L V N+L LP +G LS L+ D S N
Sbjct: 146 QMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNL 205
Query: 311 LESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKL 370
L++LP IG L SL L + N L LP + +++ ++ L SN L +P ++ ++ L
Sbjct: 206 LDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLL 265
Query: 371 RVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYMFPQQ 430
L+L DN+L++LP +L + + L N PL EA P+ + + P+
Sbjct: 266 TRLDLRDNQLRDLP---PELLDAPFVRLQGN------PL-GEASPDAPSSPVA-ALIPEM 314
Query: 431 PRGDEDFQSDSDSFNPT 447
PR SD DSF T
Sbjct: 315 PR--LFLTSDLDSFPVT 329
Score = 91.3 bits (225), Expect = 7e-18
Identities = 68/234 (29%), Positives = 111/234 (47%), Gaps = 10/234 (4%)
Query: 68 CQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCL---------T 118
CQ L L + L L L ++ + + + + P+++ C + L T
Sbjct: 47 CQQLLHLCV-QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDT 105
Query: 119 IIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPK 178
+ ++ LP G + L +L L L+ LE LPA ++ L L L N L LP+
Sbjct: 106 LGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPE 165
Query: 179 SMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMS 238
++ L L L + +N LP L + L+ L + N L LP IG L L+ L+++
Sbjct: 166 ALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLA 225
Query: 239 KNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLP 292
NR++++ ++G +L L+L SN+L +P + L LT L + DNQL LP
Sbjct: 226 SNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
Score = 84.3 bits (207), Expect = 8e-16
Identities = 53/169 (31%), Positives = 89/169 (52%)
Query: 81 LSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNL 140
L+NLP ++ L +L LD+S N ++ P + + L + S N +S+LP+ L L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 141 TQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELP 200
T L + L+ LP G L L+ L+L +N L TLP + L L L+L +N LP
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 201 EVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDI 249
L +++LR L + +N L +P + +L +L LD+ N++ + ++
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 75.9 bits (185), Expect = 3e-13
Identities = 53/158 (33%), Positives = 79/158 (50%), Gaps = 1/158 (0%)
Query: 48 LEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEF 107
L L L N +E LP + + L L + N LS LP + +L L L ++ N +Q
Sbjct: 127 LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTL 186
Query: 108 PENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILE 167
P + L ++ S N + LP L +L +L L L+ LPA+ L LR+L
Sbjct: 187 PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLV 246
Query: 168 LRENHLKTLPKSMHKLAQLERLDLGNNEFGEL-PEVLD 204
L N L ++P + +L L RLDL +N+ +L PE+LD
Sbjct: 247 LHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLD 284
Score = 73.9 bits (180), Expect = 1e-12
Identities = 52/154 (33%), Positives = 75/154 (48%), Gaps = 1/154 (0%)
Query: 27 LDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPT 86
LD S SL+ +P V R L L L N + ELP+ L AL L++ N L LP
Sbjct: 130 LDLSFNSLETLPACVLQM-RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPP 188
Query: 87 TIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLN 146
+ +L L+ LD+S+N + P I L + + N + LP L +L L L+
Sbjct: 189 ALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLH 248
Query: 147 DAFLEFLPANFGRLVKLRILELRENHLKTLPKSM 180
L +PA+ RL L L+LR+N L+ LP +
Sbjct: 249 SNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 71.2 bits (173), Expect = 7e-12
Identities = 51/166 (30%), Positives = 74/166 (44%)
Query: 58 IEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCL 117
+ LP L L L + N L LP + + L L +S N + E PE + L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 118 TIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLP 177
T + + N + LP L L +L L+ L+ LP G L L L L N L++LP
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 178 KSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLP 223
S+ L L L L +N +P L ++ L L + +N L+ LP
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 109 bits (273), Expect = 2e-23
Identities = 103/317 (32%), Positives = 147/317 (46%), Gaps = 31/317 (9%)
Query: 131 PDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLD 190
P G QLL+L L+ L F RL +L E L LP+S+ L L +
Sbjct: 44 PGGCQQLLHLCV----QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSL--VL 97
Query: 191 LGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDIS 250
G L L AL LP + L L +LD+S N +ET+ +
Sbjct: 98 KGGQRRDTLGACL------------RGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVL 145
Query: 251 GCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNE 310
L LLLS N L +LP+++G L LT L V N+L LP +G LS L+ D S N
Sbjct: 146 QMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNL 205
Query: 311 LESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKL 370
L++LP IG L SL L + N L LP + +++ ++ L SN L +P ++ ++ L
Sbjct: 206 LDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLL 265
Query: 371 RVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYMFPQQ 430
L+L DN+L++LP +L + + L N PL EA P+ + + P+
Sbjct: 266 TRLDLRDNQLRDLP---PELLDAPFVRLQGN------PL-GEASPDAPSSPVA-ALIPEM 314
Query: 431 PRGDEDFQSDSDSFNPT 447
PR SD DSF T
Sbjct: 315 PR--LFLTSDLDSFPVT 329
Score = 91.3 bits (225), Expect = 7e-18
Identities = 68/234 (29%), Positives = 111/234 (47%), Gaps = 10/234 (4%)
Query: 68 CQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCL---------T 118
CQ L L + L L L ++ + + + + P+++ C + L T
Sbjct: 47 CQQLLHLCV-QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDT 105
Query: 119 IIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPK 178
+ ++ LP G + L +L L L+ LE LPA ++ L L L N L LP+
Sbjct: 106 LGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPE 165
Query: 179 SMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMS 238
++ L L L + +N LP L + L+ L + N L LP IG L L+ L+++
Sbjct: 166 ALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLA 225
Query: 239 KNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLP 292
NR++++ ++G +L L+L SN+L +P + L LT L + DNQL LP
Sbjct: 226 SNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
Score = 84.3 bits (207), Expect = 8e-16
Identities = 53/169 (31%), Positives = 89/169 (52%)
Query: 81 LSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNL 140
L+NLP ++ L +L LD+S N ++ P + + L + S N +S+LP+ L L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 141 TQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELP 200
T L + L+ LP G L L+ L+L +N L TLP + L L L+L +N LP
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 201 EVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDI 249
L +++LR L + +N L +P + +L +L LD+ N++ + ++
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 75.9 bits (185), Expect = 3e-13
Identities = 53/158 (33%), Positives = 79/158 (50%), Gaps = 1/158 (0%)
Query: 48 LEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEF 107
L L L N +E LP + + L L + N LS LP + +L L L ++ N +Q
Sbjct: 127 LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTL 186
Query: 108 PENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILE 167
P + L ++ S N + LP L +L +L L L+ LPA+ L LR+L
Sbjct: 187 PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLV 246
Query: 168 LRENHLKTLPKSMHKLAQLERLDLGNNEFGEL-PEVLD 204
L N L ++P + +L L RLDL +N+ +L PE+LD
Sbjct: 247 LHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLD 284
Score = 73.9 bits (180), Expect = 1e-12
Identities = 52/154 (33%), Positives = 75/154 (48%), Gaps = 1/154 (0%)
Query: 27 LDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPT 86
LD S SL+ +P V R L L L N + ELP+ L AL L++ N L LP
Sbjct: 130 LDLSFNSLETLPACVLQM-RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPP 188
Query: 87 TIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLN 146
+ +L L+ LD+S+N + P I L + + N + LP L +L L L+
Sbjct: 189 ALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLH 248
Query: 147 DAFLEFLPANFGRLVKLRILELRENHLKTLPKSM 180
L +PA+ RL L L+LR+N L+ LP +
Sbjct: 249 SNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 71.2 bits (173), Expect = 7e-12
Identities = 51/166 (30%), Positives = 74/166 (44%)
Query: 58 IEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCL 117
+ LP L L L + N L LP + + L L +S N + E PE + L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 118 TIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLP 177
T + + N + LP L L +L L+ L+ LP G L L L L N L++LP
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 178 KSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLP 223
S+ L L L L +N +P L ++ L L + +N L+ LP
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
>gi|197333692 leucine rich repeat containing 8 family, member B
[Homo sapiens]
Length = 803
Score = 107 bits (267), Expect = 9e-23
Identities = 109/378 (28%), Positives = 168/378 (44%), Gaps = 40/378 (10%)
Query: 49 EELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNG-VQEF 107
+++ L + LP +F + LS+ LP+ ++ LVNLKEL + + V +
Sbjct: 420 DKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDH 479
Query: 108 PENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFL-EFLPA----NFGRLVK 162
P + L I+ + K+P L NL +LYL+ L E L F L
Sbjct: 480 PALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKN 539
Query: 163 LRILELRENHLKTLPKSMHKLA-QLERLDLGNNEFGELPEVLDQIQ---NLRELWMDNNA 218
LR L L+ + L +P+ + L L++L L N G VL+ ++ NL+ L + +
Sbjct: 540 LRTLYLKSS-LSRIPQVVTDLLPSLQKLSLDNE--GSKLVVLNNLKKMVNLKSLELISCD 596
Query: 219 LQVLPGSIGKLKMLVYLDMSKNRIETVDMDIS-------------------------GCE 253
L+ +P SI L L LD+ +N ++TV+ IS
Sbjct: 597 LERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALS 656
Query: 254 ALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELES 313
LE L L N ++ LP + L KL L + N LT +P I LS L+ F + N +E
Sbjct: 657 NLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEM 716
Query: 314 LPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLR-- 371
LP + L+ L + +N L L +G N+T + L N LE LP E+ Q L+
Sbjct: 717 LPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRN 776
Query: 372 VLNLSDNRLKNLPFSFTK 389
L + +N L LP T+
Sbjct: 777 CLIVEENLLNTLPLPVTE 794
Score = 105 bits (261), Expect = 4e-22
Identities = 78/250 (31%), Positives = 133/250 (53%), Gaps = 13/250 (5%)
Query: 29 YSHCSLQQVPKEVFNFERTLEELYLDANQIEELP-----KQLFNCQALRKLSIPDNDLSN 83
Y SL ++P+ V + +L++L LD N+ +L K++ N ++L +S DL
Sbjct: 544 YLKSSLSRIPQVVTDLLPSLQKLSLD-NEGSKLVVLNNLKKMVNLKSLELISC---DLER 599
Query: 84 LPTTIASLVNLKELDISKNGVQEFPENIKC--CKCLTIIEASVNPISKLPDGFTQLLNLT 141
+P +I SL NL ELD+ +N ++ E I + L+ ++ N I+ +P L NL
Sbjct: 600 IPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLE 659
Query: 142 QLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPE 201
QL L+ +E LP KL L+L NHL +P+ + L+ L+ + NN LP+
Sbjct: 660 QLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPD 719
Query: 202 VLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALED--LL 259
L Q + L+ L + N+L L +G+L L +L++ N +ET+ ++ GC++L+ L+
Sbjct: 720 GLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLI 779
Query: 260 LSSNMLQQLP 269
+ N+L LP
Sbjct: 780 VEENLLNTLP 789
>gi|21245134 leucine rich repeat containing 8 family, member B [Homo
sapiens]
Length = 803
Score = 107 bits (267), Expect = 9e-23
Identities = 109/378 (28%), Positives = 168/378 (44%), Gaps = 40/378 (10%)
Query: 49 EELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNG-VQEF 107
+++ L + LP +F + LS+ LP+ ++ LVNLKEL + + V +
Sbjct: 420 DKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDH 479
Query: 108 PENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFL-EFLPA----NFGRLVK 162
P + L I+ + K+P L NL +LYL+ L E L F L
Sbjct: 480 PALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKN 539
Query: 163 LRILELRENHLKTLPKSMHKLA-QLERLDLGNNEFGELPEVLDQIQ---NLRELWMDNNA 218
LR L L+ + L +P+ + L L++L L N G VL+ ++ NL+ L + +
Sbjct: 540 LRTLYLKSS-LSRIPQVVTDLLPSLQKLSLDNE--GSKLVVLNNLKKMVNLKSLELISCD 596
Query: 219 LQVLPGSIGKLKMLVYLDMSKNRIETVDMDIS-------------------------GCE 253
L+ +P SI L L LD+ +N ++TV+ IS
Sbjct: 597 LERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALS 656
Query: 254 ALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELES 313
LE L L N ++ LP + L KL L + N LT +P I LS L+ F + N +E
Sbjct: 657 NLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEM 716
Query: 314 LPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLR-- 371
LP + L+ L + +N L L +G N+T + L N LE LP E+ Q L+
Sbjct: 717 LPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRN 776
Query: 372 VLNLSDNRLKNLPFSFTK 389
L + +N L LP T+
Sbjct: 777 CLIVEENLLNTLPLPVTE 794
Score = 105 bits (261), Expect = 4e-22
Identities = 78/250 (31%), Positives = 133/250 (53%), Gaps = 13/250 (5%)
Query: 29 YSHCSLQQVPKEVFNFERTLEELYLDANQIEELP-----KQLFNCQALRKLSIPDNDLSN 83
Y SL ++P+ V + +L++L LD N+ +L K++ N ++L +S DL
Sbjct: 544 YLKSSLSRIPQVVTDLLPSLQKLSLD-NEGSKLVVLNNLKKMVNLKSLELISC---DLER 599
Query: 84 LPTTIASLVNLKELDISKNGVQEFPENIKC--CKCLTIIEASVNPISKLPDGFTQLLNLT 141
+P +I SL NL ELD+ +N ++ E I + L+ ++ N I+ +P L NL
Sbjct: 600 IPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLE 659
Query: 142 QLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPE 201
QL L+ +E LP KL L+L NHL +P+ + L+ L+ + NN LP+
Sbjct: 660 QLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPD 719
Query: 202 VLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALED--LL 259
L Q + L+ L + N+L L +G+L L +L++ N +ET+ ++ GC++L+ L+
Sbjct: 720 GLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLI 779
Query: 260 LSSNMLQQLP 269
+ N+L LP
Sbjct: 780 VEENLLNTLP 789
>gi|223005922 leucine rich repeat containing 10-like [Homo sapiens]
Length = 292
Score = 106 bits (264), Expect = 2e-22
Identities = 57/171 (33%), Positives = 96/171 (56%)
Query: 72 RKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLP 131
++L + L LP+ + +L L++L +S G++E PE I+ + L I+ N + +LP
Sbjct: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
Query: 132 DGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDL 191
DG +L LT+LYL L LPA+F +L LR L + N L+ P+ + +L L+ L +
Sbjct: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
Query: 192 GNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRI 242
G+N LP L ++ LR LW+ N + P ++ ++ L LD+ +NR+
Sbjct: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRL 194
Score = 87.8 bits (216), Expect = 7e-17
Identities = 56/174 (32%), Positives = 87/174 (50%)
Query: 120 IEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKS 179
+E S + +LP L L +LY++ L LP L +LRIL L N L+ LP
Sbjct: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
Query: 180 MHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSK 239
+ +L +L RL LG N LP Q+Q+LR LW++ N L+ P + +L L L M
Sbjct: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGD 145
Query: 240 NRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPN 293
NR+ + ++ L L L N ++ P ++ + +L L +D N+L P+
Sbjct: 146 NRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPD 199
Score = 78.2 bits (191), Expect = 6e-14
Identities = 50/173 (28%), Positives = 87/173 (50%)
Query: 166 LELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGS 225
LEL L+ LP ++ L++L++L + ELPE +++++ LR L +D N L+ LP
Sbjct: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
Query: 226 IGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDD 285
+ +L L L + NR+ + D + ++L L + N L++ P + L L +L++ D
Sbjct: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGD 145
Query: 286 NQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELP 338
N+L LP + ++ L N E P + + L L +D N L P
Sbjct: 146 NRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP 198
Score = 77.8 bits (190), Expect = 8e-14
Identities = 51/168 (30%), Positives = 83/168 (49%)
Query: 235 LDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNT 294
L++S R+ + + L+ L +S L++LP+ I L++L L +D N+L LP+
Sbjct: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
Query: 295 IGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRS 354
+ L L N L +LP+ L SLR L ++ NFL PR + + + +
Sbjct: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGD 145
Query: 355 NKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQ 402
N+L LP E+ +M LR L L NR + P + ++ L L L N+
Sbjct: 146 NRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNR 193
Score = 74.7 bits (182), Expect = 6e-13
Identities = 54/191 (28%), Positives = 90/191 (47%), Gaps = 2/191 (1%)
Query: 27 LDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPT 86
L+ S L+++P V R L++LY+ + ELP+++ + LR L++ N L LP
Sbjct: 26 LELSGRRLRRLPSAVCALSR-LQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPD 84
Query: 87 TIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLN 146
+ L L L + N + P + + L + N + + P +L+ L L +
Sbjct: 85 GLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMG 144
Query: 147 DAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQI 206
D L LPA R+ LR L L N + P ++ ++ +L LDL N G P+ L +
Sbjct: 145 DNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPD-LHPL 203
Query: 207 QNLRELWMDNN 217
+ LR D+N
Sbjct: 204 RALRVFSYDHN 214
Score = 69.3 bits (168), Expect = 3e-11
Identities = 50/175 (28%), Positives = 81/175 (46%)
Query: 210 RELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLP 269
++L + L+ LP ++ L L L +S + + +I L L L N L++LP
Sbjct: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
Query: 270 DSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAV 329
D + L +LT L + N+L LP L L N L P + L +L++L +
Sbjct: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
Query: 330 DENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLP 384
+N L LP E+ + + L N+ E P + +M +L +L+L NRL P
Sbjct: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP 198
Score = 64.3 bits (155), Expect = 9e-10
Identities = 53/198 (26%), Positives = 87/198 (43%), Gaps = 1/198 (0%)
Query: 142 QLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPE 201
QL L+ L LP+ L +L+ L + L+ LP+ + +L +L L L N+ LP+
Sbjct: 25 QLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPD 84
Query: 202 VLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLS 261
L ++ L L++ N L LP +L+ L L + N + + AL+ L +
Sbjct: 85 GLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMG 144
Query: 262 SNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYL 321
N L+ LP + + L L + N+ P + + L D N L P + L
Sbjct: 145 DNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPD-LHPL 203
Query: 322 HSLRTLAVDENFLPELPR 339
+LR + D N + PR
Sbjct: 204 RALRVFSYDHNPVTGPPR 221
>gi|37221175 PH domain and leucine rich repeat protein phosphatase
[Homo sapiens]
Length = 1205
Score = 105 bits (262), Expect = 3e-22
Identities = 109/418 (26%), Positives = 187/418 (44%), Gaps = 39/418 (9%)
Query: 34 LQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIAS--- 90
L+QV K + + + L +E LP LF Q L L++ N L P+ A+
Sbjct: 116 LRQVSKVA---SQRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGL 172
Query: 91 -----LVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYL 145
LK L++S N + +FP + L + S N + +P + NL L
Sbjct: 173 NELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLL 232
Query: 146 NDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELP-EVLD 204
+ FL+ LPA + +L L L N +P+ + KL +++L + N L + L
Sbjct: 233 DGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALR 292
Query: 205 QIQNLRELWMDNNAL-QVLPGSIGKLKMLVYLDMSKNRIETVD------MDISGCEA--- 254
++ +++ + + N + +++ + L+ + LD+ N++ +D +++ CE
Sbjct: 293 KMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQL 352
Query: 255 ---------LEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFD 305
L+ L SSN L QL D + L+ + V N+L +P + LE D
Sbjct: 353 VTLDICGYFLKALYASSNELVQL-DVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLD 411
Query: 306 CSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNK-LEFLPEEI 364
N++ LP+ + SLR L N L LP + +V V+ ++ N+ LE P +
Sbjct: 412 IGHNQICELPARLFCNSSLRKLLAGHNQLARLPERL-ERTSVEVLDVQHNQLLELPPNLL 470
Query: 365 GQMQKLRVLNLSDNRLKNLP---FSFTKLKELAALWLSDNQ-SKALIPLQTEAHPETK 418
+ LR LN S N+L++LP S L L+L++N + +PL T HP K
Sbjct: 471 MKADSLRFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLT-GHPHLK 527
Score = 82.8 bits (203), Expect = 2e-15
Identities = 104/428 (24%), Positives = 190/428 (44%), Gaps = 78/428 (18%)
Query: 24 ISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSN 83
++ L+ S +L+ VP V L+ LD N ++ LP +L N + L L + N+ ++
Sbjct: 204 LAELNVSCNALRSVPAAV-GVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTD 262
Query: 84 LPTTIASLVNLKELDISKNGVQEFP-ENIKCCKCLTIIEASVNPISKL-PDGFTQLLNLT 141
+P + L + +L +S N V+ + ++ + ++ +N I KL D L ++T
Sbjct: 263 IPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVT 322
Query: 142 QLYLNDA-------------------------------FLEFLPANFGRLVKLRI----- 165
QL L D FL+ L A+ LV+L +
Sbjct: 323 QLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLDICGYFLKALYASSNELVQLDVYPVPN 382
Query: 166 ----LELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQV 221
+++ N L+ +P+ + + +LE LD+G+N+ ELP L +LR+L +N L
Sbjct: 383 YLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLAR 442
Query: 222 LPGSIGKLKMLVYLDMSKNRIETVDMDI-SGCEALEDLLLSSNMLQQLP------DSIGL 274
LP + + + V LD+ N++ + ++ ++L L S+N L+ LP ++ +
Sbjct: 443 LPERLERTSVEV-LDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSI 501
Query: 275 LKKL---------------------TTLKVDDNQLTMLP-NTIGNLSLLEEFDCSCNELE 312
L++L L + N+L P + + L LEE D S N+L+
Sbjct: 502 LQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLK 561
Query: 313 SLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLE--FLPEEIGQMQKL 370
++P+TI + T+ N + P E+ + + L N+L LPE + KL
Sbjct: 562 AIPTTIMNCRRMHTVIAHSNCIEVFP-EVMQLPEIKCVDLSCNELSEVTLPENL--PPKL 618
Query: 371 RVLNLSDN 378
+ L+L+ N
Sbjct: 619 QELDLTGN 626
Score = 68.9 bits (167), Expect = 3e-11
Identities = 71/286 (24%), Positives = 123/286 (43%), Gaps = 40/286 (13%)
Query: 33 SLQQVPKEVFNFERTLEELYLDANQIE-----------------------ELPKQLFNCQ 69
S + V +V+ L + + N++E ELP +LF
Sbjct: 369 SNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNS 428
Query: 70 ALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKC-CKCLTIIEASVNPIS 128
+LRKL N L+ LP + +++ LD+ N + E P N+ L + AS N +
Sbjct: 429 SLRKLLAGHNQLARLPERL-ERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLE 487
Query: 129 KLP--------DGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKS- 179
LP + Q L LT L D + L + L+IL + N L++ P S
Sbjct: 488 SLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGH----PHLKILHMAYNRLQSFPASK 543
Query: 180 MHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSK 239
M KL +LE +DL N+ +P + + + + +N ++V P + +L + +D+S
Sbjct: 544 MAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFP-EVMQLPEIKCVDLSC 602
Query: 240 NRIETVDMDISGCEALEDLLLSSNMLQQLP-DSIGLLKKLTTLKVD 284
N + V + + L++L L+ N L ++ LL + K+D
Sbjct: 603 NELSEVTLPENLPPKLQELDLTGNPRLVLDHKTLELLNNIRCFKID 648
Score = 44.3 bits (103), Expect = 0.001
Identities = 51/202 (25%), Positives = 94/202 (46%), Gaps = 13/202 (6%)
Query: 18 RGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQA---LRKL 74
R E + VLD H L ++P + +L L AN++E LP + + L++L
Sbjct: 446 RLERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQEL 505
Query: 75 SIPDNDLSN-LPTTIASLVNLKELDISKNGVQEFPENIKCCKC--LTIIEASVNPISKLP 131
+ +N L++ + +LK L ++ N +Q FP + K K L I+ S N + +P
Sbjct: 506 YLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPAS-KMAKLEELEEIDLSGNKLKAIP 564
Query: 132 DGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLK--TLPKSMHKLAQLERL 189
+ + + +E P +L +++ ++L N L TLP+++ +L+ L
Sbjct: 565 TTIMNCRRMHTVIAHSNCIEVFP-EVMQLPEIKCVDLSCNELSEVTLPENLP--PKLQEL 621
Query: 190 DL-GNNEFGELPEVLDQIQNLR 210
DL GN + L+ + N+R
Sbjct: 622 DLTGNPRLVLDHKTLELLNNIR 643
>gi|63003903 leucine rich repeat containing 10 [Homo sapiens]
Length = 277
Score = 99.0 bits (245), Expect = 3e-20
Identities = 68/221 (30%), Positives = 106/221 (47%), Gaps = 24/221 (10%)
Query: 119 IIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPK 178
+++ S + + + P L +LYL+D L LP G+L L+IL L N+ K LP+
Sbjct: 33 MVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQ 92
Query: 179 SMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMS 238
+ L QL L LGNN+ +LP L +QNLR LW++ N L LP + +L +
Sbjct: 93 VVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSL------- 145
Query: 239 KNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNL 298
L+ L SN L+ LP + L++L T+ + N+LT P + ++
Sbjct: 146 ----------------LKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHM 189
Query: 299 SLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPR 339
LE D N + PS + +L SL+ + D N P+
Sbjct: 190 PFLEVIDVDWNSIRYFPS-LAHLSSLKLVIYDHNPCRNAPK 229
Score = 85.1 bits (209), Expect = 5e-16
Identities = 60/221 (27%), Positives = 99/221 (44%), Gaps = 24/221 (10%)
Query: 164 RILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLP 223
++++L + L+ P + +L +L L +N LP L Q+QNL+ L +D N + LP
Sbjct: 32 KMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALP 91
Query: 224 GSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKV 283
+ LK L L L +N L LP + LL+ L TL +
Sbjct: 92 QVVCTLKQLCIL-----------------------YLGNNKLCDLPSELSLLQNLRTLWI 128
Query: 284 DDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGS 343
+ N LT LP+ + LSLL+ N L LP + L LRT+ + N L + P +
Sbjct: 129 EANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLH 188
Query: 344 CKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLP 384
+ V+ + N + + P + + L+++ N +N P
Sbjct: 189 MPFLEVIDVDWNSIRYFP-SLAHLSSLKLVIYDHNPCRNAP 228
Score = 77.0 bits (188), Expect = 1e-13
Identities = 43/143 (30%), Positives = 74/143 (51%)
Query: 260 LSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIG 319
LS + L++ P + ++L L + DN L LP +G L L+ N ++LP +
Sbjct: 36 LSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVC 95
Query: 320 YLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNR 379
L L L + N L +LP E+ +N+ + + +N L LP+ + ++ L+ L+ N
Sbjct: 96 TLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNA 155
Query: 380 LKNLPFSFTKLKELAALWLSDNQ 402
L+ LP +L+EL +WLS N+
Sbjct: 156 LRLLPGQLRRLQELRTIWLSGNR 178
Score = 75.9 bits (185), Expect = 3e-13
Identities = 55/197 (27%), Positives = 92/197 (46%), Gaps = 8/197 (4%)
Query: 46 RTLEELYLD------ANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDI 99
R L E+ LD +Q+ P + + + L KL + DN L++LP + L NL+ L +
Sbjct: 23 RDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILAL 82
Query: 100 SKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGR 159
N + P+ + K L I+ N + LP + L NL L++ L LP
Sbjct: 83 DFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCE 142
Query: 160 LVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNAL 219
L L+ L N L+ LP + +L +L + L N + P VL + L + +D N++
Sbjct: 143 LSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSI 202
Query: 220 QVLP--GSIGKLKMLVY 234
+ P + LK+++Y
Sbjct: 203 RYFPSLAHLSSLKLVIY 219
Score = 57.0 bits (136), Expect = 1e-07
Identities = 29/97 (29%), Positives = 53/97 (54%)
Query: 305 DCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEI 364
D S ++L P + L L + +N L LP E+G +N+ +++L N + LP+ +
Sbjct: 35 DLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVV 94
Query: 365 GQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDN 401
+++L +L L +N+L +LP + L+ L LW+ N
Sbjct: 95 CTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEAN 131
Score = 33.1 bits (74), Expect = 2.1
Identities = 19/65 (29%), Positives = 31/65 (47%), Gaps = 12/65 (18%)
Query: 344 CKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQS 403
C+N V LR L+ ++++LS ++L+ P +EL L+LSDN
Sbjct: 17 CQNYVVRDLREMPLD------------KMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHL 64
Query: 404 KALIP 408
+L P
Sbjct: 65 NSLPP 69
Score = 32.3 bits (72), Expect = 3.6
Identities = 20/58 (34%), Positives = 30/58 (51%)
Query: 349 VMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKAL 406
++ L ++L P + ++L L LSDN L +LP +L+ L L L N KAL
Sbjct: 33 MVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKAL 90
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 98.2 bits (243), Expect = 5e-20
Identities = 99/324 (30%), Positives = 154/324 (47%), Gaps = 17/324 (5%)
Query: 24 ISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLF-NCQALRKLSIPDNDLS 82
+ L S + +P + + LE+L+LD N + + + +F L++L++ N L
Sbjct: 100 LKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLD 159
Query: 83 NLPTTI-ASLVNLKELDISKNGVQEFPENIKCCKC-LTIIEASVNPISKLPDGFTQLLN- 139
LP ++ +L NLK LD+S N + P+ + + L + N + L G L
Sbjct: 160 FLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGA 219
Query: 140 LTQLYLNDAFLEFL-PANFGRLVKLRILELRENHLKTLPKSMHKLA-QLERLDLGNNEFG 197
LT+L + + + P F RL L L L NHL LP ++ + L L L N
Sbjct: 220 LTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLA 279
Query: 198 ELPEVL-DQIQNLRELWMDNNALQVLP-GSIGKLKMLVYLDMSKN-RIETVDMD-ISGCE 253
ELP VL ++ L+ELW++ L+ LP + L L YL ++ + R+ + G
Sbjct: 280 ELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLG 339
Query: 254 ALEDLLLSSNMLQQLPDSIGLLK---KLTTLKVDDNQLTMLPNTI-GNLSLLEEFDCSCN 309
L+ L L SN L LPD GLL+ KL + + N+L LP + NLS LE N
Sbjct: 340 ELQVLALHSNGLTALPD--GLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHN 397
Query: 310 ELESLPSTI-GYLHSLRTLAVDEN 332
+LE+LP + G L L + + N
Sbjct: 398 QLETLPGDVFGALPRLTEVLLGHN 421
Score = 76.3 bits (186), Expect = 2e-13
Identities = 75/252 (29%), Positives = 126/252 (50%), Gaps = 10/252 (3%)
Query: 22 EIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFN-CQALRKLSIPDND 80
E + +LD S +L +PK + + LE L L +N++ L L N AL +L N
Sbjct: 170 ENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNH 229
Query: 81 LSNL-PTTIASLVNLKELDISKNGVQEFPENIKC-CKCLTIIEASVNPISKLPDG-FTQL 137
+ ++ P L NL L +S+N + P + LT++ NP+++LP F ++
Sbjct: 230 IRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEM 289
Query: 138 LNLTQLYLNDAFLEFLP-ANFGRLVKLRILELR-ENHLKTLPK-SMHKLAQLERLDLGNN 194
L +L+LN L LP A F L +LR L + L LP+ + L +L+ L L +N
Sbjct: 290 GGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSN 349
Query: 195 EFGELPE-VLDQIQNLRELWMDNNALQVLPGSIGK-LKMLVYLDMSKNRIETVDMDISGC 252
LP+ +L + LR++ + N L+ LP ++ + L L + + N++ET+ D+ G
Sbjct: 350 GLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGA 409
Query: 253 -EALEDLLLSSN 263
L ++LL N
Sbjct: 410 LPRLTEVLLGHN 421
Score = 55.1 bits (131), Expect = 5e-07
Identities = 62/223 (27%), Positives = 94/223 (42%), Gaps = 31/223 (13%)
Query: 215 DNNALQVLPGSIGKLKMLVYLDMSKNRIETV-DMDISGCEALEDLLLSSNMLQQLPDSI- 272
D++ V PG+ L L L +S+N+I + + LE L L N L+ + ++
Sbjct: 83 DSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMF 142
Query: 273 GLLKKLTTLKVDDNQLTMLPNTI-GNLSLLEEFDCSCNELESLPSTI---------GYLH 322
L L L ++ NQL LP ++ NL L+ D S N L LP + LH
Sbjct: 143 QKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLH 202
Query: 323 SLRTLAVDENFLPEL-----------------PREIGSCKNVTVMSLRSNKLEFLPEEIG 365
S R +++D L L P N++ ++L N L FLP +
Sbjct: 203 SNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALF 262
Query: 366 -QMQKLRVLNLSDNRLKNLP-FSFTKLKELAALWLSDNQSKAL 406
L +L L +N L LP F ++ L LWL+ Q + L
Sbjct: 263 LHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTL 305
Score = 52.8 bits (125), Expect = 3e-06
Identities = 48/165 (29%), Positives = 81/165 (49%), Gaps = 6/165 (3%)
Query: 250 SGCEALEDLLLSSNMLQQL-PDSIGLLKKLTTLKVDDNQLTMLPNT-IGNLSLLEEFDCS 307
SG L+ L++S + + + P + L KL TL++ N++T LP + + LLE+
Sbjct: 71 SGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLD 130
Query: 308 CNELESLPSTI-GYLHSLRTLAVDENFLPELPREI-GSCKNVTVMSLRSNKLEFLPEE-I 364
N L + + L +L+ LA+++N L LP + + +N+ ++ L N L LP+ +
Sbjct: 131 HNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLL 190
Query: 365 GQMQKLRVLNLSDNRLKNLPFS-FTKLKELAALWLSDNQSKALIP 408
G KL L L NRL +L L L L N +++ P
Sbjct: 191 GAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAP 235
>gi|190014581 leucine rich repeat containing 2 [Homo sapiens]
Length = 371
Score = 98.2 bits (243), Expect = 5e-20
Identities = 65/227 (28%), Positives = 116/227 (51%), Gaps = 5/227 (2%)
Query: 163 LRILELRENHLKT----LPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNA 218
+R+L+ E + T LPK K + +L + ELP+ L + +LRE ++ N
Sbjct: 73 VRLLDKIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTL 132
Query: 219 LQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKL 278
+Q++P I + + LD+ KN+I + +I + L++L + N L+ +P +G + L
Sbjct: 133 IQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENL 192
Query: 279 TTLKVDDN-QLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPEL 337
L N +L LP + NL + D S N+ S+P + + +L+ L + N L +L
Sbjct: 193 ERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDL 252
Query: 338 PREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLP 384
P++I + + L NKL +LP + ++KL +L +S + L LP
Sbjct: 253 PQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELP 299
Score = 94.4 bits (233), Expect = 8e-19
Identities = 65/232 (28%), Positives = 113/232 (48%), Gaps = 2/232 (0%)
Query: 153 LPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLREL 212
LP + G+ + EL H LP S+ + L + N +P + Q +R L
Sbjct: 90 LPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRIL 149
Query: 213 WMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNM-LQQLPDS 271
+ N + LP IG LK L L++ N ++++ ++ CE LE L S N+ L +LP
Sbjct: 150 DLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFE 209
Query: 272 IGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDE 331
+ LK++T + + N+ + +P + +S L+ D S N L LP I L L++ + +
Sbjct: 210 LSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYK 269
Query: 332 NFLPELPREIGSCKNVTVMSLRSNKLEFLPEEI-GQMQKLRVLNLSDNRLKN 382
N L LP + + K +T++ + + L LP + L+ ++L DN + N
Sbjct: 270 NKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMDNPIDN 321
Score = 90.9 bits (224), Expect = 9e-18
Identities = 58/201 (28%), Positives = 101/201 (50%), Gaps = 1/201 (0%)
Query: 119 IIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPK 178
+ E S ++LPD + +L + Y+++ ++ +P +RIL+L +N + LP
Sbjct: 102 VFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPA 161
Query: 179 SMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNA-LQVLPGSIGKLKMLVYLDM 237
+ L L+ L++G N +P L +NL L N L LP + LK + ++D+
Sbjct: 162 EIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDI 221
Query: 238 SKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGN 297
S N+ +V + + L+ L +SSN L LP I L++L + + N+LT LP ++ N
Sbjct: 222 SANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLN 281
Query: 298 LSLLEEFDCSCNELESLPSTI 318
L L S + L LP+ +
Sbjct: 282 LKKLTLLVVSGDHLVELPTAL 302
Score = 84.3 bits (207), Expect = 8e-16
Identities = 64/215 (29%), Positives = 98/215 (45%), Gaps = 24/215 (11%)
Query: 82 SNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLT 141
+ LP ++ +L+E IS +Q P I+ + + I++ N IS LP
Sbjct: 111 TELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLP---------- 160
Query: 142 QLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDL-GNNEFGELP 200
A G L L+ L + N+LK++P + LERLD GN E ELP
Sbjct: 161 -------------AEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELP 207
Query: 201 EVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLL 260
L ++ + + + N +P + ++ L +LD+S N + + DI E L+ LL
Sbjct: 208 FELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLL 267
Query: 261 SSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTI 295
N L LP S+ LKKLT L V + L LP +
Sbjct: 268 YKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTAL 302
Score = 80.9 bits (198), Expect = 9e-15
Identities = 57/217 (26%), Positives = 105/217 (48%), Gaps = 24/217 (11%)
Query: 48 LEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEF 107
L E Y+ I+ +P + QA+R L +P N +S+LP I L NLKEL++ N ++
Sbjct: 123 LREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSI 182
Query: 108 PENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILE 167
P + C+ L ++ S N L L + LP L ++ ++
Sbjct: 183 PPELGDCENLERLDCSGN------------LELME----------LPFELSNLKQVTFVD 220
Query: 168 LRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIG 227
+ N ++P + +++ L+ LD+ +N +LP+ +D+++ L+ + N L LP S+
Sbjct: 221 ISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSML 280
Query: 228 KLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNM 264
LK L L +S + + V++ + C++ L S M
Sbjct: 281 NLKKLTLLVVSGDHL--VELPTALCDSSTPLKFVSLM 315
Score = 71.2 bits (173), Expect = 7e-12
Identities = 53/175 (30%), Positives = 87/175 (49%), Gaps = 2/175 (1%)
Query: 30 SHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIA 89
S+ +Q +P + F+ + L L NQI LP ++ + L++L++ N L ++P +
Sbjct: 129 SNTLIQIIPTYIQLFQ-AMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELG 187
Query: 90 SLVNLKELDISKN-GVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDA 148
NL+ LD S N + E P + K +T ++ S N S +P ++ NL L ++
Sbjct: 188 DCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSN 247
Query: 149 FLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVL 203
L LP + RL +L+ L +N L LP SM L +L L + + ELP L
Sbjct: 248 NLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTAL 302
Score = 48.1 bits (113), Expect = 6e-05
Identities = 35/132 (26%), Positives = 58/132 (43%), Gaps = 3/132 (2%)
Query: 282 KVDDNQLTM---LPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELP 338
K++ N LT LP G S F+ S LP ++ LR + + +P
Sbjct: 78 KIERNTLTRQSSLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIP 137
Query: 339 REIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWL 398
I + + ++ L N++ LP EIG ++ L+ LN+ N LK++P + L L
Sbjct: 138 TYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDC 197
Query: 399 SDNQSKALIPLQ 410
S N +P +
Sbjct: 198 SGNLELMELPFE 209
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.131 0.383
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,674,433
Number of Sequences: 37866
Number of extensions: 3244124
Number of successful extensions: 11450
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 137
Number of HSP's successfully gapped in prelim test: 321
Number of HSP's that attempted gapping in prelim test: 8012
Number of HSP's gapped (non-prelim): 2049
length of query: 1537
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1422
effective length of database: 13,892,928
effective search space: 19755743616
effective search space used: 19755743616
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.